{
  "schema": "picoportal.search-run-provenance/1",
  "exportedAt": "2026-10-29T13:16:56.134Z",
  "tool": {
    "name": "PICO search builder",
    "database": "PubMed via NCBI E-utilities",
    "vocabulary": "NLM MeSH via id.nlm.nih.gov"
  },
  "aiUse": {
    "modelsServed": [
      "claude-opus-5-5"
    ],
    "statement": "The PubMed search strategy was drafted with the PICO search builder. It used the large language model claude-opus-5-5 (Anthropic; accessed October 28, 2026) to propose search concepts and terms from the review question. The tool made 1 call to the model at high effort (the draft); claude-opus-5-5 was requested and answered it. Every MeSH heading, Supplementary Concept and publication type the strategy searches was checked against NLM MeSH (id.nlm.nih.gov) before use: 23 valid. Each numbered line was run in PubMed through NCBI E-utilities on October 28, 2026, and PubMed's own diagnostics (phrases not found, ignored words, lost truncation) were checked. The strategy was tested against 6 known relevant studies that were not shown to the model: 4 were retrieved (95% CI 22%–96%). Retrieving known studies does not prove the search is complete. 2 further known studies were shown to the model as examples. 1 further known study could not be matched to a single PubMed record, so it was not tested: \"Cognition and Memory after Covid-19 in a Large Community Sample\". Compared with the reference strategy, the strategy retrieves 391 of the reference's 521 records (relative recall 75%). Relative recall counts every record the reference retrieves, relevant or not, so it does not show how many relevant studies the strategy finds. A searcher must review the strategy before it is used. The prompts, the model output and every version are in the provenance file (JSON export)."
  },
  "run": {
    "id": "0960c5fd-8bfc-48dc-87c0-0848c4fa0e21",
    "kind": "question",
    "status": "done",
    "stage": "saving",
    "question": "What is the association between COVID-19 vaccination and neurocognitive outcomes of COVID-19, including long COVID and multisystem inflammatory syndrome in children?",
    "input": {
      "seeds": [
        "38918610",
        "38130975",
        "39857653",
        "40144475",
        "39787799",
        "39657038",
        "10.1093/braincomms/fcae448",
        "Cognition and Memory after Covid-19 in a Large Community Sample",
        "Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections"
      ],
      "limits": {
        "dateTo": null,
        "dateFrom": "2020",
        "languages": [
          "english"
        ],
        "humansOnly": false,
        "excludePublicationTypes": [
          {
            "label": "Comment",
            "validation": {
              "status": "unchecked"
            }
          },
          {
            "label": "Case Reports",
            "validation": {
              "status": "unchecked"
            }
          },
          {
            "label": "Editorial",
            "validation": {
              "status": "unchecked"
            }
          },
          {
            "label": "Preprint",
            "validation": {
              "status": "unchecked"
            }
          }
        ]
      },
      "question": "What is the association between COVID-19 vaccination and neurocognitive outcomes of COVID-19, including long COVID and multisystem inflammatory syndrome in children?",
      "referenceStrategy": "PubMed:\nProvider: NLM\nDate(s) Searched: July 8, 2026\nDate range searched: 2020-present\nSearch Terms:\n\n |  | \n1 | COVID-19[Majr] OR Post-Acute COVID-19 Syndrome[Majr] or \"pediatric multisystem inflammatory disease, COVID-19 related\" [Supplementary Concept]  | 251,600 / \n2 | “COVID 19”[ti] OR “SARS Coronavirus 2 Infection”[ti] OR “2019-nCoV Infection”[ti] OR “2019 nCoV Infection”[ti] OR “2019-nCoV Infections”[ti] OR “Infection 2019-nCoV”[ti] OR “SARS-CoV-2 Infection”[ti] OR “Infection SARS-CoV-2”[ti] OR “SARS CoV 2 Infection”[ti] OR “SARS-CoV-2 Infections”[ti] OR “2019 Novel Coronavirus Disease”[ti] OR “2019 Novel Coronavirus Infection”[ti] OR “2019-nCoV Disease”[ti] OR “2019 nCoV Disease”[ti] OR “Disease 2019-nCoV”[ti] OR “COVID19”[ti] OR “Coronavirus Disease 2019”[ti] OR “Severe Acute Respiratory Syndrome Coronavirus 2 Infection”[ti] OR “COVID-19 Virus Disease”[ti] OR “COVID 19 Virus Disease”[ti] OR “Virus Disease COVID-19”[ti] OR “Coronavirus Disease-19”[ti] OR “Coronavirus Disease 19”[ti] OR “COVID-19 Virus Infection”[ti] OR “COVID 19 Virus Infection”[ti] OR “COVID-19 Virus Infections”[ti] OR “Virus Infection COVID-19”[ti] | 317,902  / \n3 | \"Long COVID\"[ti] OR \"Long Haul COVID-19\"[ti] OR \"Long-Haul COVID\"[ti] OR \"Neuro PASC\"[ti] OR \"Post Acute COVID-19 Syndrome\"[ti] OR \"Post COVID-19 Syndrome\"[ti] OR \"Post-Acute COVID-19 Sequelae\"[ti] OR \"Post-Acute Sequelae SARS-CoV-2 Infection\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"Post-COVID-19 Syndrome\"[ti] | 5,629 / \n4 | multisystem inflammatory syndrome in children[tw] | 2,249\n5 | 1 or 2 or 3 or 4 | 399,700\n6 | Cognition[Majr:noexp] OR Sensation[Majr:noexp] OR \"Psychomotor Performance\"[Mesh] OR \"Attention\"[Majr:noexp] OR \"Memory\"[Majr:noexp] OR \"Deja Vu\"[Mesh] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Long-Term\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Mental Recall\"[Mesh] OR \"Recognition, Psychology\"[Mesh] OR \"Repetition Priming\"[Mesh] OR \"Retention, Psychology\"[Mesh] OR \"Spatial Memory\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Clinical Reasoning\"[Mesh] OR \"Problem Solving\"[Mesh] OR \"Processing Speed\"[Mesh] OR \"Language Development\"[Mesh] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurodevelopment\"[Mesh] OR \"Neuropathology\"[Mesh] or \"Memory Disorders\"[Mesh] or \"Brain\"[Mesh] or “Neurologic Manifestations”[Majr:noexp] | 1,652,543 /  / \n7 | cognition[ti] OR \"cognitive function\"[ti] or sensation[ti] or \"sensory function\"[ti] or \"sensory processing\"[ti] or \"psychomotor performance\"[ti] or \"sensory motor performance\"[ti]  or attention[ti] or \"mental concentration\"[ti] or memory[ti] or \"immediate recall\"[ti] or \"mental recall\"[ti] or \"repetition priming\"[ti] or \"executive function\"[ti] or \"executive control\"[ti] or \"clinical reasoning\"[ti] or \"clinical judgement\"[ti] or \"problem solving\"[ti] or \"processing speed\"[ti] or \"language development\"[ti] or \"language acquisition\"[ti] or “cognitive defect”[tiab] or \"cognitive dysfunction\"[tiab] or \"cognitive impairment\"[tiab] or neurodevelopment[ti] or neuropathology[ti] or neurocognitive[tiab] or brain[ti] or neurocognition[tiab] or “neurological symptom*”[tiab] or \"neurologic disorder*\"[tiab] or \"neurological disorder*\"[tiab] | 833,979 /  /  / \n8 | cognition[ot] OR \"cognitive function\"[ot] or sensation[ot] or \"sensory function\"[ot] or \"sensory processing\"[ot] or \"psychomotor performance\"[ot] or \"sensory motor performance\"[ot]  or attention[ot] or \"mental concentration\"[ot] or memory[ot] or \"immediate recall\"[ot] or \"mental recall\"[ot] or \"psychological recognition\"[ot] or \"repetition priming\"[ot] or \"executive function\"[ot] or \"executive control\"[ot] or \"clinical reasoning\"[ot] or \"clinical judgement\"[ot] or \"problem solving\"[ot] or \"processing speed\"[ot] or \"language development\"[ot] or \"language acquisition\"[ot] or “cognitive defect”[ot] or \"cognitive dysfunction\"[ot] or \"cognitive impairment\"[ot] or neurodevelopment[ot] or neuropathology[ot] or neurocognitive[ot] or brain[ot] or neurocognition[ot] or “neurological symptom*”[ot] or \"neurologic disorder*\"[ot] or \"neurological disorder*\"[ot] | 373,079  / \n9 | 6 or 7 or 8 | 2,134,656\n10 | \"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\" [Supplementary Concept] | 59,837 / \n11 | “COVID 19 Vaccines”[ti] OR “Vaccines COVID-19”[ti] OR “Coronavirus Disease 2019 Vaccines”[ti] OR “Coronavirus Disease 2019 Vaccine”[ti] OR “Coronavirus Disease-19 Vaccines”[ti] OR “Coronavirus Disease 19 Vaccines”[ti] OR “Coronavirus Disease-19 Vaccine”[ti] OR “Coronavirus Disease 19 Vaccine”[ti] OR “COVID 19 Vaccine”[ti] OR “Vaccine COVID 19”[ti] OR “2019-nCoV Vaccine”[ti] OR “SARS-CoV-2 Vaccine”[ti] OR “SARS CoV 2 Vaccine”[ti] OR “Vaccine SARS-CoV-2”[ti] OR “COVID-19 Vaccine”[ti] OR “SARS Coronavirus 2 Vaccines”[ti] OR “Virus Vaccines COVID-19”[ti] OR “COVID19 Vaccine”[ti] OR “SARS-CoV-2 Vaccines”[ti] OR “SARS CoV 2 Vaccines”[ti] OR “Vaccines SARS-CoV-2”[ti] or vaccination[ti] or vaccination[ot] or “breakthrough infection*”[ti] or “breakthrough infection*”[ot] | 105,227  / \n12 | 10 or 11 | 128,852\n13 | 5 and 9 and 12 | 590\n14 | \"Comment\" [Publication Type] or \"Case Reports\" [Publication Type] or \"Conference Proceedings\" [Publication Type] or \"Editorial\" [Publication Type] or \"Preprint\" [Publication Type] | 3,751,353\n15 | 13 NOT 14 | 503\n16 | Language: English | 503\n---\n\n"
    },
    "strategy": {
      "notes": [
        "The searcher's publication-type exclusions (Comment, Case Reports, Editorial, Preprint) are final, so excludePublicationTypes is empty.",
        "Following the model strategy, the outcome block is required because the review is defined by neurocognitive outcomes.",
        "Vaccine-specific headings (BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, ChAdOx1 nCoV-19, Ad26COVS1) are not listed separately because they fall under the exploded COVID-19 Vaccines heading.",
        "vaccin* in tiab is broad, but ANDing with the COVID and neuro blocks keeps the result small; it is needed because example 1 mentions vaccination only in its abstract.",
        "Broad neurology headings (Nervous System Diseases, Headache) and mental-health terms were left out to keep the outcome block focused on neurocognition; add them if the searcher wants to include broader neurological sequelae.",
        "The abbreviation PASC alone was left out because it is ambiguous; the spelled-out form and neuro-PASC are included."
      ],
      "blocks": [
        {
          "key": "covid",
          "role": "condition",
          "label": "COVID-19, long COVID and MIS-C",
          "terms": [
            {
              "id": "covid-mesh-0",
              "kind": "mesh",
              "label": "COVID-19",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Core heading for the disease that must be a main topic.",
              "validation": {
                "ui": "D000086382",
                "label": "COVID-19",
                "status": "valid"
              }
            },
            {
              "id": "covid-mesh-1",
              "kind": "mesh",
              "label": "Post-Acute COVID-19 Syndrome",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Heading for long COVID, a named part of the question.",
              "validation": {
                "ui": "D000094024",
                "label": "Post-Acute COVID-19 Syndrome",
                "status": "valid"
              }
            },
            {
              "id": "covid-mesh-2",
              "kind": "mesh",
              "label": "SARS-CoV-2",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Virus heading catches records indexed on the infecting agent.",
              "validation": {
                "ui": "D000086402",
                "label": "SARS-CoV-2",
                "status": "valid"
              }
            },
            {
              "id": "covid-scr-0",
              "kind": "scr",
              "label": "pediatric multisystem inflammatory disease, COVID-19 related",
              "origin": "ai",
              "enabled": true,
              "rationale": "Supplementary Concept for MIS-C, a named part of the question.",
              "validation": {
                "ui": "C000705967",
                "label": "pediatric multisystem inflammatory disease, COVID-19 related",
                "status": "valid"
              }
            },
            {
              "id": "covid-text-0",
              "kind": "text",
              "text": "COVID-19",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Main disease name in titles."
            },
            {
              "id": "covid-text-1",
              "kind": "text",
              "text": "COVID19",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Unhyphenated spelling variant."
            },
            {
              "id": "covid-text-2",
              "kind": "text",
              "text": "COVID 19",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Spaced spelling variant."
            },
            {
              "id": "covid-text-3",
              "kind": "text",
              "text": "SARS-CoV-2",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Virus name used in titles about infection."
            },
            {
              "id": "covid-text-4",
              "kind": "text",
              "text": "SARS CoV 2",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Unhyphenated variant of the virus name."
            },
            {
              "id": "covid-text-5",
              "kind": "text",
              "text": "SARS-CoV-2 Infection",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Entry term of COVID-19."
            },
            {
              "id": "covid-text-6",
              "kind": "text",
              "text": "Coronavirus Disease 2019",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Full entry term of COVID-19."
            },
            {
              "id": "covid-text-7",
              "kind": "text",
              "text": "2019 novel coronavirus",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Early name used in 2020 titles."
            },
            {
              "id": "covid-text-8",
              "kind": "text",
              "text": "Long COVID",
              "fields": [
                "ti",
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Common name for post-acute COVID-19 syndrome, used as title word and keyword in the examples."
            },
            {
              "id": "covid-text-9",
              "kind": "text",
              "text": "Post-COVID Conditions",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Entry term of Post-Acute COVID-19 Syndrome."
            },
            {
              "id": "covid-text-10",
              "kind": "text",
              "text": "post-COVID-19 condition",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "WHO term for long COVID."
            },
            {
              "id": "covid-text-11",
              "kind": "text",
              "text": "post-acute sequelae of SARS-CoV-2",
              "fields": [
                "ti",
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "PASC full name used in example 2."
            },
            {
              "id": "covid-text-12",
              "kind": "text",
              "text": "post-acute COVID-19 syndrome",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Heading name used as title words."
            },
            {
              "id": "covid-text-13",
              "kind": "text",
              "text": "long-haul COVID",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Lay variant for long COVID."
            },
            {
              "id": "covid-text-14",
              "kind": "text",
              "text": "post-COVID",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Prefix form used in titles such as post-COVID cognitive impairment."
            },
            {
              "id": "covid-text-15",
              "kind": "text",
              "text": "MIS-C",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Distinctive abbreviation for multisystem inflammatory syndrome in children."
            },
            {
              "id": "covid-text-16",
              "kind": "text",
              "text": "multisystem inflammatory syndrome in children",
              "fields": [
                "tw"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Distinctive multi-word name of MIS-C."
            },
            {
              "id": "covid-text-17",
              "kind": "text",
              "text": "paediatric inflammatory multisystem syndrome",
              "fields": [
                "tw"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "British name (PIMS-TS) for MIS-C."
            },
            {
              "id": "covid-mesh-0-et2",
              "kind": "text",
              "text": "2019-nCoV Disease",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086382"
            },
            {
              "id": "covid-mesh-0-et3",
              "kind": "text",
              "text": "COVID-19 Pandemic",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086382"
            },
            {
              "id": "covid-mesh-0-et4",
              "kind": "text",
              "text": "COVID-19 Pandemics",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086382"
            },
            {
              "id": "covid-mesh-0-et5",
              "kind": "text",
              "text": "2019-nCoV Infection",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086382"
            },
            {
              "id": "covid-mesh-0-et7",
              "kind": "text",
              "text": "Coronavirus Disease-19",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086382"
            },
            {
              "id": "covid-mesh-0-et8",
              "kind": "text",
              "text": "COVID-19 Virus Disease",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086382"
            },
            {
              "id": "covid-mesh-1-et3",
              "kind": "text",
              "text": "Long Haul COVID-19",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000094024"
            },
            {
              "id": "covid-mesh-1-et5",
              "kind": "text",
              "text": "Post COVID-19 Syndrome",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000094024"
            },
            {
              "id": "covid-mesh-1-et6",
              "kind": "text",
              "text": "Post-COVID-19 Syndrome",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000094024"
            },
            {
              "id": "covid-mesh-1-et7",
              "kind": "text",
              "text": "Post Acute COVID-19 Syndrome",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000094024"
            },
            {
              "id": "covid-mesh-1-et8",
              "kind": "text",
              "text": "Post-Acute COVID-19 Sequelae",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000094024"
            },
            {
              "id": "covid-mesh-1-et9",
              "kind": "text",
              "text": "Post-Acute Sequelae of COVID-19",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000094024"
            },
            {
              "id": "covid-mesh-2-et1",
              "kind": "text",
              "text": "2019-nCoV",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086402"
            },
            {
              "id": "covid-mesh-2-et2",
              "kind": "text",
              "text": "COVID19 Virus",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086402"
            },
            {
              "id": "covid-mesh-2-et3",
              "kind": "text",
              "text": "COVID-19 Virus",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086402"
            },
            {
              "id": "covid-mesh-2-et4",
              "kind": "text",
              "text": "SARS-CoV-2 Virus",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086402"
            },
            {
              "id": "covid-mesh-2-et5",
              "kind": "text",
              "text": "Wuhan Coronavirus",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086402"
            },
            {
              "id": "covid-mesh-2-et6",
              "kind": "text",
              "text": "SARS Coronavirus 2",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086402"
            }
          ],
          "required": true
        },
        {
          "key": "neuro",
          "role": "outcome",
          "label": "Neurocognitive and neurological outcomes",
          "terms": [
            {
              "id": "neuro-mesh-0",
              "kind": "mesh",
              "label": "Cognition",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": false,
              "rationale": "Central cognition heading without noisy narrower headings.",
              "validation": {
                "ui": "D003071",
                "label": "Cognition",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-1",
              "kind": "mesh",
              "label": "Cognitive Dysfunction",
              "major": false,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Specific heading for cognitive impairment, including post-COVID cognitive deficits.",
              "validation": {
                "ui": "D060825",
                "label": "Cognitive Dysfunction",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-2",
              "kind": "mesh",
              "label": "Neurocognitive Disorders",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": false,
              "rationale": "Heading for neurocognitive disorders as a main topic.",
              "validation": {
                "ui": "D019965",
                "label": "Neurocognitive Disorders",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-3",
              "kind": "mesh",
              "label": "Memory, Episodic",
              "major": false,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Memory domain affected after COVID.",
              "validation": {
                "ui": "D061212",
                "label": "Memory, Episodic",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-4",
              "kind": "mesh",
              "label": "Memory, Short-Term",
              "major": false,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Working memory domain often tested.",
              "validation": {
                "ui": "D008570",
                "label": "Memory, Short-Term",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-5",
              "kind": "mesh",
              "label": "Memory Disorders",
              "major": false,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Memory impairment outcomes.",
              "validation": {
                "ui": "D008569",
                "label": "Memory Disorders",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-6",
              "kind": "mesh",
              "label": "Executive Function",
              "major": false,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Cognitive domain named in the model strategy.",
              "validation": {
                "ui": "D056344",
                "label": "Executive Function",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-7",
              "kind": "mesh",
              "label": "Attention",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": false,
              "rationale": "Attention domain without unrelated narrower headings.",
              "validation": {
                "ui": "D001288",
                "label": "Attention",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-8",
              "kind": "mesh",
              "label": "Mental Fatigue",
              "major": false,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Closest heading for brain fog and cognitive fatigue.",
              "validation": {
                "ui": "D005222",
                "label": "Mental Fatigue",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-9",
              "kind": "mesh",
              "label": "Neurologic Manifestations",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": false,
              "rationale": "Neurological symptoms of COVID and long COVID.",
              "validation": {
                "ui": "D009461",
                "label": "Neurologic Manifestations",
                "status": "valid"
              }
            },
            {
              "id": "neuro-mesh-10",
              "kind": "mesh",
              "label": "Neuropsychological Tests",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": false,
              "rationale": "Records whose main topic is cognitive testing.",
              "validation": {
                "ui": "D009483",
                "label": "Neuropsychological Tests",
                "status": "valid"
              }
            },
            {
              "id": "neuro-text-0",
              "kind": "text",
              "text": "cognition",
              "fields": [
                "ti",
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Core outcome word and author keyword in example 1."
            },
            {
              "id": "neuro-text-1",
              "kind": "text",
              "text": "cognitive",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Adjective in titles about cognitive impairment or outcomes."
            },
            {
              "id": "neuro-text-2",
              "kind": "text",
              "text": "neurocognitive",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Outcome term defining the review."
            },
            {
              "id": "neuro-text-3",
              "kind": "text",
              "text": "memory",
              "fields": [
                "ti",
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Memory outcomes appear in titles and keywords."
            },
            {
              "id": "neuro-text-4",
              "kind": "text",
              "text": "executive function",
              "fields": [
                "ti",
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Cognitive domain named by authors."
            },
            {
              "id": "neuro-text-5",
              "kind": "text",
              "text": "cognitive impairment",
              "fields": [
                "tiab",
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Common finding in abstracts and keywords."
            },
            {
              "id": "neuro-text-6",
              "kind": "text",
              "text": "cognitive dysfunction",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Heading name used in abstracts."
            },
            {
              "id": "neuro-text-7",
              "kind": "text",
              "text": "cognitive decline",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Outcome phrasing in abstracts."
            },
            {
              "id": "neuro-text-8",
              "kind": "text",
              "text": "cognitive deficit",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": true,
              "proximity": null,
              "rationale": "Finding with singular and plural forms."
            },
            {
              "id": "neuro-text-9",
              "kind": "text",
              "text": "cognitive symptom",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": true,
              "proximity": null,
              "rationale": "Symptom phrasing in long COVID abstracts."
            },
            {
              "id": "neuro-text-10",
              "kind": "text",
              "text": "memory impairment",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Memory finding in abstracts."
            },
            {
              "id": "neuro-text-11",
              "kind": "text",
              "text": "brain fog",
              "fields": [
                "tiab",
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Lay term for long COVID cognitive symptoms."
            },
            {
              "id": "neuro-text-12",
              "kind": "text",
              "text": "neuropsychological",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Testing and outcome term used by authors."
            },
            {
              "id": "neuro-text-13",
              "kind": "text",
              "text": "neurological symptom",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": true,
              "proximity": null,
              "rationale": "Neurological outcome phrasing."
            },
            {
              "id": "neuro-text-14",
              "kind": "text",
              "text": "neurologic symptom",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": true,
              "proximity": null,
              "rationale": "American spelling variant."
            },
            {
              "id": "neuro-text-15",
              "kind": "text",
              "text": "neurological manifestation",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": true,
              "proximity": null,
              "rationale": "Phrasing for neurological sequelae."
            },
            {
              "id": "neuro-text-16",
              "kind": "text",
              "text": "neurologic manifestation",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": true,
              "proximity": null,
              "rationale": "Variant used in the title of example 2."
            },
            {
              "id": "neuro-text-17",
              "kind": "text",
              "text": "neuro-PASC",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Term for neurological long COVID used in example 2."
            },
            {
              "id": "neuro-text-18",
              "kind": "text",
              "text": "neurology",
              "fields": [
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Author keyword in example 2."
            },
            {
              "id": "neuro-mesh-0-et1",
              "kind": "text",
              "text": "Insight",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D003071"
            },
            {
              "id": "neuro-mesh-0-et2",
              "kind": "text",
              "text": "Cognitive Function",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D003071"
            },
            {
              "id": "neuro-mesh-1-et2",
              "kind": "text",
              "text": "Cognitive Disorder",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D060825"
            },
            {
              "id": "neuro-mesh-1-et3",
              "kind": "text",
              "text": "Mental Deterioration",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D060825"
            },
            {
              "id": "neuro-mesh-1-et4",
              "kind": "text",
              "text": "Cognitive Impairments",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D060825"
            },
            {
              "id": "neuro-mesh-1-et5",
              "kind": "text",
              "text": "Mild Cognitive Impairment",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D060825"
            },
            {
              "id": "neuro-mesh-2-et1",
              "kind": "text",
              "text": "Kandinsky Syndrome",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D019965"
            },
            {
              "id": "neuro-mesh-2-et2",
              "kind": "text",
              "text": "Clerambault Syndrome",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D019965"
            },
            {
              "id": "neuro-mesh-2-et3",
              "kind": "text",
              "text": "Organic Mental Disorders",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D019965"
            },
            {
              "id": "neuro-mesh-2-et4",
              "kind": "text",
              "text": "Mild Neurocognitive Disorder",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D019965"
            },
            {
              "id": "neuro-mesh-2-et5",
              "kind": "text",
              "text": "Nonpsychotic Organic Brain Syndrome",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D019965"
            },
            {
              "id": "neuro-mesh-3-et1",
              "kind": "text",
              "text": "Episodic Memory",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D061212"
            },
            {
              "id": "neuro-mesh-3-et2",
              "kind": "text",
              "text": "Prospective Memory",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D061212"
            },
            {
              "id": "neuro-mesh-3-et3",
              "kind": "text",
              "text": "Autobiographical Memory",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D061212"
            },
            {
              "id": "neuro-mesh-4-et1",
              "kind": "text",
              "text": "Working Memory",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D008570"
            },
            {
              "id": "neuro-mesh-4-et2",
              "kind": "text",
              "text": "Immediate Recall",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D008570"
            },
            {
              "id": "neuro-mesh-5-et1",
              "kind": "text",
              "text": "Memory Loss",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D008569"
            },
            {
              "id": "neuro-mesh-5-et2",
              "kind": "text",
              "text": "Memory Deficits",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D008569"
            },
            {
              "id": "neuro-mesh-5-et3",
              "kind": "text",
              "text": "Spatial Memory Disorder",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D008569"
            },
            {
              "id": "neuro-mesh-5-et4",
              "kind": "text",
              "text": "Semantic Memory Disorder",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D008569"
            },
            {
              "id": "neuro-mesh-5-et5",
              "kind": "text",
              "text": "Age-Related Memory Disorders",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D008569"
            },
            {
              "id": "neuro-mesh-6-et1",
              "kind": "text",
              "text": "Executive Control",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D056344"
            },
            {
              "id": "neuro-mesh-7-et1",
              "kind": "text",
              "text": "Social Attention",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D001288"
            },
            {
              "id": "neuro-mesh-7-et2",
              "kind": "text",
              "text": "Focus of Attention",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D001288"
            },
            {
              "id": "neuro-mesh-7-et3",
              "kind": "text",
              "text": "Selective Attention",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D001288"
            },
            {
              "id": "neuro-mesh-7-et4",
              "kind": "text",
              "text": "Mental Concentration",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D001288"
            },
            {
              "id": "neuro-mesh-8-et2",
              "kind": "text",
              "text": "Mental Fog",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D005222"
            },
            {
              "id": "neuro-mesh-8-et3",
              "kind": "text",
              "text": "Cognitive Weariness",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D005222"
            },
            {
              "id": "neuro-mesh-8-et4",
              "kind": "text",
              "text": "Cognitive Exhaustion",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D005222"
            },
            {
              "id": "neuro-mesh-9-et1",
              "kind": "text",
              "text": "Neurologic Signs",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009461"
            },
            {
              "id": "neuro-mesh-9-et2",
              "kind": "text",
              "text": "Neurologic Deficits",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009461"
            },
            {
              "id": "neuro-mesh-9-et3",
              "kind": "text",
              "text": "Neurologic Findings",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009461"
            },
            {
              "id": "neuro-mesh-9-et4",
              "kind": "text",
              "text": "Neurologic Symptoms",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009461"
            },
            {
              "id": "neuro-mesh-9-et5",
              "kind": "text",
              "text": "Neurologic Dysfunction",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009461"
            },
            {
              "id": "neuro-mesh-9-et7",
              "kind": "text",
              "text": "Focal Neurologic Deficits",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009461"
            },
            {
              "id": "neuro-mesh-10-et1",
              "kind": "text",
              "text": "NEPSY",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009483"
            },
            {
              "id": "neuro-mesh-10-et2",
              "kind": "text",
              "text": "AX-CPT",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009483"
            },
            {
              "id": "neuro-mesh-10-et3",
              "kind": "text",
              "text": "CANTAB",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009483"
            },
            {
              "id": "neuro-mesh-10-et4",
              "kind": "text",
              "text": "Clock Test",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009483"
            },
            {
              "id": "neuro-mesh-10-et5",
              "kind": "text",
              "text": "Aphasia Tests",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009483"
            },
            {
              "id": "neuro-mesh-10-et6",
              "kind": "text",
              "text": "Cognitive Test",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D009483"
            }
          ],
          "required": true
        },
        {
          "key": "vaccine",
          "role": "exposure",
          "label": "COVID-19 vaccination",
          "terms": [
            {
              "id": "vaccine-mesh-0",
              "kind": "mesh",
              "label": "COVID-19 Vaccines",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Core heading; exploding it includes the specific vaccine headings such as BNT162.",
              "validation": {
                "ui": "D000086663",
                "label": "COVID-19 Vaccines",
                "status": "valid"
              }
            },
            {
              "id": "vaccine-mesh-1",
              "kind": "mesh",
              "label": "Vaccination",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Act of vaccination as a main topic.",
              "validation": {
                "ui": "D014611",
                "label": "Vaccination",
                "status": "valid"
              }
            },
            {
              "id": "vaccine-mesh-2",
              "kind": "mesh",
              "label": "Breakthrough Infections",
              "major": true,
              "origin": "ai",
              "enabled": true,
              "explode": true,
              "rationale": "Infection after vaccination, which shows vaccination status.",
              "validation": {
                "ui": "D000093742",
                "label": "Breakthrough Infections",
                "status": "valid"
              }
            },
            {
              "id": "vaccine-scr-0",
              "kind": "scr",
              "label": "COVID-19 breakthrough infections",
              "origin": "ai",
              "enabled": true,
              "rationale": "Supplementary Concept for COVID-19 breakthrough infections.",
              "validation": {
                "ui": "C000718127",
                "label": "COVID-19 breakthrough infections",
                "status": "valid"
              }
            },
            {
              "id": "vaccine-text-0",
              "kind": "text",
              "text": "vaccin",
              "fields": [
                "ti",
                "tiab",
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": true,
              "proximity": null,
              "rationale": "Covers vaccine, vaccines, vaccination and vaccinated; example 1 names vaccination only in the abstract."
            },
            {
              "id": "vaccine-text-1",
              "kind": "text",
              "text": "immunization",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Synonym of vaccination."
            },
            {
              "id": "vaccine-text-2",
              "kind": "text",
              "text": "immunisation",
              "fields": [
                "ti"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "British spelling."
            },
            {
              "id": "vaccine-text-3",
              "kind": "text",
              "text": "breakthrough infection",
              "fields": [
                "ti",
                "tiab",
                "ot"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": true,
              "proximity": null,
              "rationale": "Phrasing for infection after vaccination, used in example 2."
            },
            {
              "id": "vaccine-text-4",
              "kind": "text",
              "text": "BNT162b2",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Pfizer-BioNTech vaccine name."
            },
            {
              "id": "vaccine-text-5",
              "kind": "text",
              "text": "mRNA-1273",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Moderna vaccine name."
            },
            {
              "id": "vaccine-text-6",
              "kind": "text",
              "text": "ChAdOx1",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "AstraZeneca vaccine name."
            },
            {
              "id": "vaccine-text-7",
              "kind": "text",
              "text": "Ad26.COV2.S",
              "fields": [
                "tiab"
              ],
              "origin": "ai",
              "enabled": true,
              "truncate": false,
              "proximity": null,
              "rationale": "Janssen vaccine name."
            },
            {
              "id": "vaccine-mesh-0-et1",
              "kind": "text",
              "text": "SARS2 Vaccine",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086663"
            },
            {
              "id": "vaccine-mesh-0-et2",
              "kind": "text",
              "text": "SARS2 Vaccines",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086663"
            },
            {
              "id": "vaccine-mesh-0-et3",
              "kind": "text",
              "text": "COVID19 Vaccine",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086663"
            },
            {
              "id": "vaccine-mesh-0-et4",
              "kind": "text",
              "text": "COVID 19 Vaccine",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086663"
            },
            {
              "id": "vaccine-mesh-0-et5",
              "kind": "text",
              "text": "COVID-19 Vaccine",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086663"
            },
            {
              "id": "vaccine-mesh-0-et6",
              "kind": "text",
              "text": "COVID19 Vaccines",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000086663"
            },
            {
              "id": "vaccine-mesh-2-et1",
              "kind": "text",
              "text": "Treatment Emergent Infections",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000093742"
            },
            {
              "id": "vaccine-mesh-2-et2",
              "kind": "text",
              "text": "Vaccine Breakthrough Infections",
              "fields": [
                "tiab"
              ],
              "origin": "mesh_entry_term",
              "enabled": false,
              "truncate": false,
              "proximity": null,
              "rationale": "MeSH entry term of D000093742"
            }
          ],
          "required": true
        }
      ],
      "limits": {
        "dateTo": null,
        "dateFrom": "2020",
        "languages": [
          "english"
        ],
        "humansOnly": false,
        "excludePublicationTypes": [
          {
            "label": "Comment",
            "validation": {
              "ui": "D016420",
              "label": "Comment",
              "status": "valid"
            }
          },
          {
            "label": "Case Reports",
            "validation": {
              "ui": "D002363",
              "label": "Case Reports",
              "status": "valid"
            }
          },
          {
            "label": "Editorial",
            "validation": {
              "ui": "D016421",
              "label": "Editorial",
              "status": "valid"
            }
          },
          {
            "label": "Preprint",
            "validation": {
              "ui": "D000076942",
              "label": "Preprint",
              "status": "valid"
            }
          }
        ]
      },
      "schema": "picoportal.search-strategy/1",
      "question": "What is the association between COVID-19 vaccination and neurocognitive outcomes of COVID-19, including long COVID and multisystem inflammatory syndrome in children?",
      "objective": "To identify studies examining whether COVID-19 vaccination is associated with neurocognitive and neurological outcomes of COVID-19, including long COVID (post-acute sequelae) and multisystem inflammatory syndrome in children (MIS-C)."
    },
    "lines": [
      {
        "no": 1,
        "kind": "terms",
        "refs": [],
        "count": 268269,
        "query": "\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]",
        "issues": [],
        "display": "\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]",
        "termIds": [
          "covid-mesh-0",
          "covid-mesh-1",
          "covid-mesh-2",
          "covid-scr-0"
        ],
        "blockKey": "covid",
        "countedAt": "2026-10-28T12:23:20.613Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"COVID-19\"[MeSH Major Topic] OR \"Post-Acute COVID-19 Syndrome\"[MeSH Major Topic] OR \"SARS-CoV-2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 2,
        "kind": "terms",
        "refs": [],
        "count": 387506,
        "query": "\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]",
        "issues": [],
        "display": "\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]",
        "termIds": [
          "covid-text-0",
          "covid-text-1",
          "covid-text-2",
          "covid-text-3",
          "covid-text-4",
          "covid-text-5",
          "covid-text-6",
          "covid-text-7",
          "covid-text-8",
          "covid-text-9",
          "covid-text-10",
          "covid-text-11",
          "covid-text-12",
          "covid-text-13",
          "covid-text-14"
        ],
        "blockKey": "covid",
        "countedAt": "2026-10-28T12:23:20.882Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post-acute COVID-19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 3,
        "kind": "terms",
        "refs": [],
        "count": 2453,
        "query": "\"MIS-C\"[tiab]",
        "issues": [],
        "display": "\"MIS-C\"[tiab]",
        "termIds": [
          "covid-text-15"
        ],
        "blockKey": "covid",
        "countedAt": "2026-10-28T12:23:21.410Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"MIS-C\"[Title/Abstract]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 4,
        "kind": "terms",
        "refs": [],
        "count": 2403,
        "query": "\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]",
        "issues": [],
        "display": "\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]",
        "termIds": [
          "covid-text-16",
          "covid-text-17"
        ],
        "blockKey": "covid",
        "countedAt": "2026-10-28T12:23:24.625Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 5,
        "kind": "terms",
        "refs": [],
        "count": 5477,
        "query": "\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot]",
        "issues": [],
        "display": "\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot]",
        "termIds": [
          "covid-text-8",
          "covid-text-11"
        ],
        "blockKey": "covid",
        "countedAt": "2026-10-28T12:23:21.917Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 6,
        "kind": "block",
        "refs": [
          1,
          2,
          3,
          4,
          5
        ],
        "count": 440033,
        "query": "(\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])",
        "issues": [],
        "display": "1 OR 2 OR 3 OR 4 OR 5",
        "blockKey": "covid",
        "countedAt": "2026-10-28T12:23:22.273Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR \"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title] OR \"MIS-C\"[Title/Abstract] OR \"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word] OR \"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 7,
        "kind": "terms",
        "refs": [],
        "count": 281973,
        "query": "\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]",
        "issues": [],
        "display": "\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]",
        "termIds": [
          "neuro-mesh-0",
          "neuro-mesh-1",
          "neuro-mesh-2",
          "neuro-mesh-3",
          "neuro-mesh-4",
          "neuro-mesh-5",
          "neuro-mesh-6",
          "neuro-mesh-7",
          "neuro-mesh-8",
          "neuro-mesh-9",
          "neuro-mesh-10"
        ],
        "blockKey": "neuro",
        "countedAt": "2026-10-28T12:23:22.600Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 8,
        "kind": "terms",
        "refs": [],
        "count": 320765,
        "query": "cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]",
        "issues": [],
        "display": "cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]",
        "termIds": [
          "neuro-text-0",
          "neuro-text-1",
          "neuro-text-3",
          "neuro-text-4"
        ],
        "blockKey": "neuro",
        "countedAt": "2026-10-28T12:23:22.949Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"executive function\"[Title]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 9,
        "kind": "terms",
        "refs": [],
        "count": 324011,
        "query": "neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]",
        "issues": [],
        "display": "neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]",
        "termIds": [
          "neuro-text-2",
          "neuro-text-5",
          "neuro-text-6",
          "neuro-text-7",
          "neuro-text-8",
          "neuro-text-9",
          "neuro-text-10",
          "neuro-text-11",
          "neuro-text-12",
          "neuro-text-13",
          "neuro-text-14",
          "neuro-text-15",
          "neuro-text-16",
          "neuro-text-17"
        ],
        "blockKey": "neuro",
        "countedAt": "2026-10-28T12:23:23.281Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"cognitive dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 10,
        "kind": "terms",
        "refs": [],
        "count": 151788,
        "query": "cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot]",
        "issues": [],
        "display": "cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot]",
        "termIds": [
          "neuro-text-0",
          "neuro-text-3",
          "neuro-text-4",
          "neuro-text-5",
          "neuro-text-11",
          "neuro-text-18"
        ],
        "blockKey": "neuro",
        "countedAt": "2026-10-28T12:23:23.683Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"cognition\"[Other Term] OR \"memory\"[Other Term] OR \"executive function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 11,
        "kind": "block",
        "refs": [
          7,
          8,
          9,
          10
        ],
        "count": 682882,
        "query": "(\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])",
        "issues": [],
        "display": "7 OR 8 OR 9 OR 10",
        "blockKey": "neuro",
        "countedAt": "2026-10-28T12:23:23.991Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR \"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title] OR \"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract] OR \"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 12,
        "kind": "terms",
        "refs": [],
        "count": 74035,
        "query": "\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]",
        "issues": [],
        "display": "\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]",
        "termIds": [
          "vaccine-mesh-0",
          "vaccine-mesh-1",
          "vaccine-mesh-2",
          "vaccine-scr-0"
        ],
        "blockKey": "vaccine",
        "countedAt": "2026-10-28T03:24:35.704Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 13,
        "kind": "terms",
        "refs": [],
        "count": 294470,
        "query": "vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]",
        "issues": [],
        "display": "vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]",
        "termIds": [
          "vaccine-text-0",
          "vaccine-text-1",
          "vaccine-text-2",
          "vaccine-text-3"
        ],
        "blockKey": "vaccine",
        "countedAt": "2026-10-28T12:23:24.285Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 14,
        "kind": "terms",
        "refs": [],
        "count": 510697,
        "query": "vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]",
        "issues": [],
        "display": "vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]",
        "termIds": [
          "vaccine-text-0",
          "vaccine-text-3",
          "vaccine-text-4",
          "vaccine-text-5",
          "vaccine-text-6",
          "vaccine-text-7"
        ],
        "blockKey": "vaccine",
        "countedAt": "2026-10-28T12:23:24.980Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 15,
        "kind": "terms",
        "refs": [],
        "count": 130196,
        "query": "vaccin*[ot] OR \"breakthrough infection*\"[ot]",
        "issues": [],
        "display": "vaccin*[ot] OR \"breakthrough infection*\"[ot]",
        "termIds": [
          "vaccine-text-0",
          "vaccine-text-3"
        ],
        "blockKey": "vaccine",
        "countedAt": "2026-10-28T12:23:25.291Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 16,
        "kind": "block",
        "refs": [
          12,
          13,
          14,
          15
        ],
        "count": 532214,
        "query": "(\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot])",
        "issues": [],
        "display": "12 OR 13 OR 14 OR 15",
        "blockKey": "vaccine",
        "countedAt": "2026-10-28T12:23:25.712Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR \"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title] OR \"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract] OR \"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 17,
        "kind": "combine",
        "refs": [
          6,
          11,
          16
        ],
        "count": 1237,
        "query": "((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))",
        "issues": [],
        "display": "6 AND 11 AND 16",
        "countedAt": "2026-10-28T12:23:26.083Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "(\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR (\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]) OR \"MIS-C\"[Title/Abstract] OR (\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]) OR (\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term])) AND (\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR (\"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title]) OR (\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]) OR (\"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term])) AND (\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR (\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]) OR (\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]) OR (\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]))",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 18,
        "kind": "exclude",
        "refs": [],
        "count": 4270113,
        "query": "\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type]",
        "issues": [],
        "display": "\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type]",
        "countedAt": "2026-10-28T12:23:26.335Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type]",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 19,
        "kind": "not",
        "refs": [
          17,
          18
        ],
        "count": 1078,
        "query": "(((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])",
        "issues": [],
        "display": "17 NOT 18",
        "countedAt": "2026-10-28T12:23:26.837Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "((\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR (\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]) OR \"MIS-C\"[Title/Abstract] OR (\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]) OR (\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term])) AND (\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR (\"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title]) OR (\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]) OR (\"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term])) AND (\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR (\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]) OR (\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]) OR (\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])",
          "quotedPhrasesNotFound": []
        }
      },
      {
        "no": 20,
        "kind": "limits",
        "refs": [
          19
        ],
        "count": 1072,
        "query": "((((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND english[la] AND 2020:3000[dp]",
        "issues": [],
        "display": "19 AND english[la] AND 2020:3000[dp]",
        "countedAt": "2026-10-28T12:23:27.102Z",
        "diagnostics": {
          "fieldsNotFound": [],
          "outputMessages": [],
          "phrasesIgnored": [],
          "translationSet": [],
          "phrasesNotFound": [],
          "queryTranslation": "(((\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR (\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]) OR \"MIS-C\"[Title/Abstract] OR (\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]) OR (\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term])) AND (\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR (\"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title]) OR (\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]) OR (\"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term])) AND (\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR (\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]) OR (\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]) OR (\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND \"english\"[Language] AND 2020/01/01:3000/12/31[Date - Publication]",
          "quotedPhrasesNotFound": []
        }
      }
    ],
    "finalQuery": "((((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND english[la] AND 2020:3000[dp]",
    "finalCount": 1072,
    "issues": [
      {
        "code": "language_limit",
        "level": "warning",
        "message": "Language limit (english): it can remove relevant studies; report and justify it."
      },
      {
        "code": "publication_type_limit",
        "level": "warning",
        "message": "Publication types excluded with NOT (Comment, Case Reports, Editorial, Preprint): report and justify the exclusion."
      },
      {
        "level": "warning",
        "code": "seeds_unresolved",
        "message": "1 of 9 known studies was not matched to a single PubMed record, so it is left out of the recall check. \"Cognition and Memory after Covid-19 in a Large Community Sample\": not matched to a PubMed record. Check it, or enter the study's PMID or DOI under Known studies."
      }
    ],
    "recall": {
      "k": 4,
      "n": 6,
      "lower": 0.22277809550351207,
      "seeds": [
        {
          "pmid": "38918610",
          "role": "validation",
          "input": "38918610",
          "retrieved": true,
          "resolvedBy": "pmid"
        },
        {
          "pmid": "38130975",
          "role": "validation",
          "input": "38130975",
          "retrieved": true,
          "resolvedBy": "pmid"
        },
        {
          "pmid": "39857653",
          "role": "development",
          "input": "39857653",
          "retrieved": true,
          "resolvedBy": "pmid"
        },
        {
          "pmid": "40144475",
          "role": "validation",
          "input": "40144475",
          "retrieved": true,
          "resolvedBy": "pmid"
        },
        {
          "pmid": "39787799",
          "role": "validation",
          "input": "39787799",
          "retrieved": true,
          "resolvedBy": "pmid"
        },
        {
          "pmid": "39657038",
          "role": "validation",
          "input": "39657038",
          "retrieved": false,
          "excludedBy": [
            "neuro"
          ],
          "resolvedBy": "pmid"
        },
        {
          "pmid": "39777257",
          "role": "development",
          "input": "10.1093/braincomms/fcae448",
          "retrieved": true,
          "resolvedBy": "doi"
        },
        {
          "pmid": null,
          "role": "validation",
          "input": "Cognition and Memory after Covid-19 in a Large Community Sample",
          "title": "Cognition and Memory after Covid-19 in a Large Community Sample",
          "resolvedBy": null
        },
        {
          "pmid": "35447302",
          "role": "validation",
          "input": "Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections",
          "title": "Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections",
          "retrieved": false,
          "excludedBy": [
            "neuro"
          ],
          "resolvedBy": "title"
        }
      ],
      "upper": 0.9567281317072582
    },
    "seeds": [
      {
        "pmid": "38918610",
        "role": "validation",
        "input": "38918610",
        "resolvedBy": "pmid"
      },
      {
        "pmid": "38130975",
        "role": "validation",
        "input": "38130975",
        "resolvedBy": "pmid"
      },
      {
        "pmid": "39857653",
        "role": "development",
        "input": "39857653",
        "resolvedBy": "pmid"
      },
      {
        "pmid": "40144475",
        "role": "validation",
        "input": "40144475",
        "resolvedBy": "pmid"
      },
      {
        "pmid": "39787799",
        "role": "validation",
        "input": "39787799",
        "resolvedBy": "pmid"
      },
      {
        "pmid": "39657038",
        "role": "validation",
        "input": "39657038",
        "resolvedBy": "pmid"
      },
      {
        "pmid": "39777257",
        "role": "development",
        "input": "10.1093/braincomms/fcae448",
        "resolvedBy": "doi"
      },
      {
        "pmid": null,
        "role": "validation",
        "input": "Cognition and Memory after Covid-19 in a Large Community Sample",
        "title": "Cognition and Memory after Covid-19 in a Large Community Sample",
        "resolvedBy": null
      },
      {
        "pmid": "35447302",
        "role": "validation",
        "input": "Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections",
        "title": "Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections",
        "resolvedBy": "title"
      }
    ],
    "reference": {
      "overlapCount": 391,
      "generatedCount": 1072,
      "referenceCount": 521,
      "referenceQuery": "((((COVID-19[Majr] OR Post-Acute COVID-19 Syndrome[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID 19\"[ti] OR \"SARS Coronavirus 2 Infection\"[ti] OR \"2019-nCoV Infection\"[ti] OR \"2019 nCoV Infection\"[ti] OR \"2019-nCoV Infections\"[ti] OR \"Infection 2019-nCoV\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Infection SARS-CoV-2\"[ti] OR \"SARS CoV 2 Infection\"[ti] OR \"SARS-CoV-2 Infections\"[ti] OR \"2019 Novel Coronavirus Disease\"[ti] OR \"2019 Novel Coronavirus Infection\"[ti] OR \"2019-nCoV Disease\"[ti] OR \"2019 nCoV Disease\"[ti] OR \"Disease 2019-nCoV\"[ti] OR \"COVID19\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"Severe Acute Respiratory Syndrome Coronavirus 2 Infection\"[ti] OR \"COVID-19 Virus Disease\"[ti] OR \"COVID 19 Virus Disease\"[ti] OR \"Virus Disease COVID-19\"[ti] OR \"Coronavirus Disease-19\"[ti] OR \"Coronavirus Disease 19\"[ti] OR \"COVID-19 Virus Infection\"[ti] OR \"COVID 19 Virus Infection\"[ti] OR \"COVID-19 Virus Infections\"[ti] OR \"Virus Infection COVID-19\"[ti]) OR (\"Long COVID\"[ti] OR \"Long Haul COVID-19\"[ti] OR \"Long-Haul COVID\"[ti] OR \"Neuro PASC\"[ti] OR \"Post Acute COVID-19 Syndrome\"[ti] OR \"Post COVID-19 Syndrome\"[ti] OR \"Post-Acute COVID-19 Sequelae\"[ti] OR \"Post-Acute Sequelae SARS-CoV-2 Infection\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"Post-COVID-19 Syndrome\"[ti]) OR (multisystem inflammatory syndrome in children[tw])) AND ((Cognition[Majr:noexp] OR Sensation[Majr:noexp] OR \"Psychomotor Performance\"[Mesh] OR \"Attention\"[Majr:noexp] OR \"Memory\"[Majr:noexp] OR \"Deja Vu\"[Mesh] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Long-Term\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Mental Recall\"[Mesh] OR \"Recognition, Psychology\"[Mesh] OR \"Repetition Priming\"[Mesh] OR \"Retention, Psychology\"[Mesh] OR \"Spatial Memory\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Clinical Reasoning\"[Mesh] OR \"Problem Solving\"[Mesh] OR \"Processing Speed\"[Mesh] OR \"Language Development\"[Mesh] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurodevelopment\"[Mesh] OR \"Neuropathology\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Brain\"[Mesh] OR \"Neurologic Manifestations\"[Majr:noexp]) OR (cognition[ti] OR \"cognitive function\"[ti] OR sensation[ti] OR \"sensory function\"[ti] OR \"sensory processing\"[ti] OR \"psychomotor performance\"[ti] OR \"sensory motor performance\"[ti] OR attention[ti] OR \"mental concentration\"[ti] OR memory[ti] OR \"immediate recall\"[ti] OR \"mental recall\"[ti] OR \"repetition priming\"[ti] OR \"executive function\"[ti] OR \"executive control\"[ti] OR \"clinical reasoning\"[ti] OR \"clinical judgement\"[ti] OR \"problem solving\"[ti] OR \"processing speed\"[ti] OR \"language development\"[ti] OR \"language acquisition\"[ti] OR \"cognitive defect\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive impairment\"[tiab] OR neurodevelopment[ti] OR neuropathology[ti] OR neurocognitive[tiab] OR brain[ti] OR neurocognition[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic disorder*\"[tiab] OR \"neurological disorder*\"[tiab]) OR (cognition[ot] OR \"cognitive function\"[ot] OR sensation[ot] OR \"sensory function\"[ot] OR \"sensory processing\"[ot] OR \"psychomotor performance\"[ot] OR \"sensory motor performance\"[ot] OR attention[ot] OR \"mental concentration\"[ot] OR memory[ot] OR \"immediate recall\"[ot] OR \"mental recall\"[ot] OR \"psychological recognition\"[ot] OR \"repetition priming\"[ot] OR \"executive function\"[ot] OR \"executive control\"[ot] OR \"clinical reasoning\"[ot] OR \"clinical judgement\"[ot] OR \"problem solving\"[ot] OR \"processing speed\"[ot] OR \"language development\"[ot] OR \"language acquisition\"[ot] OR \"cognitive defect\"[ot] OR \"cognitive dysfunction\"[ot] OR \"cognitive impairment\"[ot] OR neurodevelopment[ot] OR neuropathology[ot] OR neurocognitive[ot] OR brain[ot] OR neurocognition[ot] OR \"neurological symptom*\"[ot] OR \"neurologic disorder*\"[ot] OR \"neurological disorder*\"[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (\"COVID 19 Vaccines\"[ti] OR \"Vaccines COVID-19\"[ti] OR \"Coronavirus Disease 2019 Vaccines\"[ti] OR \"Coronavirus Disease 2019 Vaccine\"[ti] OR \"Coronavirus Disease-19 Vaccines\"[ti] OR \"Coronavirus Disease 19 Vaccines\"[ti] OR \"Coronavirus Disease-19 Vaccine\"[ti] OR \"Coronavirus Disease 19 Vaccine\"[ti] OR \"COVID 19 Vaccine\"[ti] OR \"Vaccine COVID 19\"[ti] OR \"2019-nCoV Vaccine\"[ti] OR \"SARS-CoV-2 Vaccine\"[ti] OR \"SARS CoV 2 Vaccine\"[ti] OR \"Vaccine SARS-CoV-2\"[ti] OR \"COVID-19 Vaccine\"[ti] OR \"SARS Coronavirus 2 Vaccines\"[ti] OR \"Virus Vaccines COVID-19\"[ti] OR \"COVID19 Vaccine\"[ti] OR \"SARS-CoV-2 Vaccines\"[ti] OR \"SARS CoV 2 Vaccines\"[ti] OR \"Vaccines SARS-CoV-2\"[ti] OR vaccination[ti] OR vaccination[ot] OR \"breakthrough infection*\"[ti] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Conference Proceedings\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND english[la]",
      "relativeRecall": 0.7504798464491362
    },
    "records": [
      {
        "pmid": "42943491",
        "year": "2026",
        "title": "SARS-CoV-2 Breakthrough Infection Reveals Platform-Associated Long-Term Immune Remodeling in a Central Asian Cohort.",
        "authors": "Akhmaltdinova L, Bekbossynova M, Dossybayeva K et al.",
        "journal": "Microorganisms"
      },
      {
        "pmid": "42923005",
        "year": "2026",
        "title": "EpiFloripa COVID-Tel: methods and results of the telephone survey on the COVID-19 pandemic among older adults participating in the 2017-2019 and 2021-2022 EpiFloripa cohort study.",
        "authors": "Funk E, Hillesheim D, Figueiró TH et al.",
        "journal": "Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil"
      },
      {
        "pmid": "42905886",
        "year": "2026",
        "title": "Protective Effect of COVID-19 Vaccination on Post-Infection Visuospatial Deficits.",
        "authors": "da Silva LG, Fini BCD, Oliveira JCM et al.",
        "journal": "Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)"
      },
      {
        "pmid": "42900956",
        "year": "2026",
        "title": "Protective Effect of COVID-19 Vaccination on Post-Infection Visuospatial Deficits.",
        "authors": "da Silva LG, Fini BCD, Oliveira JCM et al.",
        "journal": "Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)"
      },
      {
        "pmid": "42881804",
        "year": "2026",
        "title": "Self-Rated Health and Persistent Symptoms Among Adults Reporting Previous SARS-CoV-2 Infection: A Cross-Sectional Study.",
        "authors": "Weber D, Łuczyk RJ, Pacian A et al.",
        "journal": "Journal of clinical medicine"
      },
      {
        "pmid": "42863757",
        "year": "2026",
        "title": "Circulating SARS-CoV-2 RNA detection in acute COVID-19 disease and post-COVID condition.",
        "authors": "Rovito R, Terracciano L, De Pinto G et al.",
        "journal": "Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases"
      },
      {
        "pmid": "42841133",
        "year": "2026",
        "title": "Prior COVID-19 vaccination and cognitive outcomes after SARS-CoV-2 infection: a mini-review.",
        "authors": "da Silva LG, Oliveira JCM, Fini BCD et al.",
        "journal": "Dementia & neuropsychologia"
      },
      {
        "pmid": "42836482",
        "year": "2026",
        "title": "Immune checkpoint inhibition enhances memory T-cell responses to CEF(T), SARS-CoV-2 spike proteins and ChAdOx1 nCoV-19.",
        "authors": "Grice S, Gardner J, Thomson P et al.",
        "journal": "Human vaccines & immunotherapeutics"
      },
      {
        "pmid": "42750672",
        "year": "2026",
        "title": "Memory B cell response to SARS-CoV-2 vaccination in people with heart and lung transplantation: Identification of associated clinical factors.",
        "authors": "Coppola C, Costagli S, Montesi G et al.",
        "journal": "iScience"
      },
      {
        "pmid": "42718410",
        "year": "2024",
        "title": "SARS-CoV-2 memory response in non-hospitalised cases: immunology in the context of a population-based cohort study.",
        "authors": "Mitchell RE, Kibble M, Santopaolo M et al.",
        "journal": "Wellcome open research"
      },
      {
        "pmid": "42705227",
        "year": "2026",
        "title": "Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection.",
        "authors": "Zhang Q, Chen P, Guo F et al.",
        "journal": "Immunity"
      },
      {
        "pmid": "42675735",
        "year": "2026",
        "title": "Long-term adverse effects following COVID-19 vaccination: A comparative analysis of Oxford AstraZeneca, Pfizer-BioNTech, and Moderna vaccines.",
        "authors": "Aldali JA, Meo SA",
        "journal": "Medicine"
      },
      {
        "pmid": "42628376",
        "year": "2026",
        "title": "Role of plasmacytoid dendritic cells in humoural and CD8(+) T-cell memory responses following BNT162b2 mRNA vaccination: a preclinical mouse study.",
        "authors": "Pizzichetti C, Latino I, Virgilio T et al.",
        "journal": "EBioMedicine"
      },
      {
        "pmid": "42625910",
        "year": "2026",
        "title": "Differential functional immune recall across homologous and heterologous COVID-19 vaccination regimens.",
        "authors": "Che-Kamaruddin N, Johari J, Yahaya H et al.",
        "journal": "Frontiers in immunology"
      },
      {
        "pmid": "42599142",
        "year": "2026",
        "title": "Incidence and clinical characteristics of amyotrophic lateral sclerosis during the post-COVID-19 Period: a population-based study from Isfahan, Iran.",
        "authors": "Etemadifar M, Salari M, Kashefi M et al.",
        "journal": "Neurodegenerative disease management"
      },
      {
        "pmid": "42590004",
        "year": "2026",
        "title": "Determinants and Consequences of Long Impact of COVID-19: A National Cross-Sectional Study in Saudi Arabia.",
        "authors": "Alshomrani A, Hussaini AS, Miskeen E",
        "journal": "Journal of clinical medicine"
      },
      {
        "pmid": "42568479",
        "year": "2026",
        "title": "Conserved CD4 T-cell responses correlate with antibody neutralization in solid organ transplant recipients after bivalent SARS-CoV-2 vaccination.",
        "authors": "Stavrakis G, Roznik K, Stoddart L et al.",
        "journal": "Frontiers in immunology"
      },
      {
        "pmid": "42543573",
        "year": "2026",
        "title": "Long COVID symptom trajectories according to post-COVID-19 vaccination status: a prospective longitudinal study.",
        "authors": "Benli A, Ala Selek S, Başaran S et al.",
        "journal": "Japanese journal of infectious diseases"
      },
      {
        "pmid": "42543244",
        "year": "2026",
        "title": "Predicting parents' COVID-19 vaccination intentions and behavior for their children: application of an integrated social cognition model.",
        "authors": "Griffith ZM, Royer Z, Gaffney AM et al.",
        "journal": "Psychology & health"
      },
      {
        "pmid": "42522246",
        "year": "2026",
        "title": "The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.",
        "authors": "Kubo M",
        "journal": "Immunological reviews"
      }
    ],
    "error": null,
    "createdAt": "2026-10-28T12:22:25.188Z",
    "finishedAt": "2026-10-28T12:23:30.410Z",
    "versionNo": 1
  },
  "versions": [
    {
      "versionNo": 1,
      "createdBy": "ai",
      "strategy": {
        "notes": [
          "The searcher's publication-type exclusions (Comment, Case Reports, Editorial, Preprint) are final, so excludePublicationTypes is empty.",
          "Following the model strategy, the outcome block is required because the review is defined by neurocognitive outcomes.",
          "Vaccine-specific headings (BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, ChAdOx1 nCoV-19, Ad26COVS1) are not listed separately because they fall under the exploded COVID-19 Vaccines heading.",
          "vaccin* in tiab is broad, but ANDing with the COVID and neuro blocks keeps the result small; it is needed because example 1 mentions vaccination only in its abstract.",
          "Broad neurology headings (Nervous System Diseases, Headache) and mental-health terms were left out to keep the outcome block focused on neurocognition; add them if the searcher wants to include broader neurological sequelae.",
          "The abbreviation PASC alone was left out because it is ambiguous; the spelled-out form and neuro-PASC are included."
        ],
        "blocks": [
          {
            "key": "covid",
            "role": "condition",
            "label": "COVID-19, long COVID and MIS-C",
            "terms": [
              {
                "id": "covid-mesh-0",
                "kind": "mesh",
                "label": "COVID-19",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Core heading for the disease that must be a main topic.",
                "validation": {
                  "ui": "D000086382",
                  "label": "COVID-19",
                  "status": "valid"
                }
              },
              {
                "id": "covid-mesh-1",
                "kind": "mesh",
                "label": "Post-Acute COVID-19 Syndrome",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Heading for long COVID, a named part of the question.",
                "validation": {
                  "ui": "D000094024",
                  "label": "Post-Acute COVID-19 Syndrome",
                  "status": "valid"
                }
              },
              {
                "id": "covid-mesh-2",
                "kind": "mesh",
                "label": "SARS-CoV-2",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Virus heading catches records indexed on the infecting agent.",
                "validation": {
                  "ui": "D000086402",
                  "label": "SARS-CoV-2",
                  "status": "valid"
                }
              },
              {
                "id": "covid-scr-0",
                "kind": "scr",
                "label": "pediatric multisystem inflammatory disease, COVID-19 related",
                "origin": "ai",
                "enabled": true,
                "rationale": "Supplementary Concept for MIS-C, a named part of the question.",
                "validation": {
                  "ui": "C000705967",
                  "label": "pediatric multisystem inflammatory disease, COVID-19 related",
                  "status": "valid"
                }
              },
              {
                "id": "covid-text-0",
                "kind": "text",
                "text": "COVID-19",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Main disease name in titles."
              },
              {
                "id": "covid-text-1",
                "kind": "text",
                "text": "COVID19",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Unhyphenated spelling variant."
              },
              {
                "id": "covid-text-2",
                "kind": "text",
                "text": "COVID 19",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Spaced spelling variant."
              },
              {
                "id": "covid-text-3",
                "kind": "text",
                "text": "SARS-CoV-2",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Virus name used in titles about infection."
              },
              {
                "id": "covid-text-4",
                "kind": "text",
                "text": "SARS CoV 2",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Unhyphenated variant of the virus name."
              },
              {
                "id": "covid-text-5",
                "kind": "text",
                "text": "SARS-CoV-2 Infection",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Entry term of COVID-19."
              },
              {
                "id": "covid-text-6",
                "kind": "text",
                "text": "Coronavirus Disease 2019",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Full entry term of COVID-19."
              },
              {
                "id": "covid-text-7",
                "kind": "text",
                "text": "2019 novel coronavirus",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Early name used in 2020 titles."
              },
              {
                "id": "covid-text-8",
                "kind": "text",
                "text": "Long COVID",
                "fields": [
                  "ti",
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Common name for post-acute COVID-19 syndrome, used as title word and keyword in the examples."
              },
              {
                "id": "covid-text-9",
                "kind": "text",
                "text": "Post-COVID Conditions",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Entry term of Post-Acute COVID-19 Syndrome."
              },
              {
                "id": "covid-text-10",
                "kind": "text",
                "text": "post-COVID-19 condition",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "WHO term for long COVID."
              },
              {
                "id": "covid-text-11",
                "kind": "text",
                "text": "post-acute sequelae of SARS-CoV-2",
                "fields": [
                  "ti",
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "PASC full name used in example 2."
              },
              {
                "id": "covid-text-12",
                "kind": "text",
                "text": "post-acute COVID-19 syndrome",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Heading name used as title words."
              },
              {
                "id": "covid-text-13",
                "kind": "text",
                "text": "long-haul COVID",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Lay variant for long COVID."
              },
              {
                "id": "covid-text-14",
                "kind": "text",
                "text": "post-COVID",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Prefix form used in titles such as post-COVID cognitive impairment."
              },
              {
                "id": "covid-text-15",
                "kind": "text",
                "text": "MIS-C",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Distinctive abbreviation for multisystem inflammatory syndrome in children."
              },
              {
                "id": "covid-text-16",
                "kind": "text",
                "text": "multisystem inflammatory syndrome in children",
                "fields": [
                  "tw"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Distinctive multi-word name of MIS-C."
              },
              {
                "id": "covid-text-17",
                "kind": "text",
                "text": "paediatric inflammatory multisystem syndrome",
                "fields": [
                  "tw"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "British name (PIMS-TS) for MIS-C."
              },
              {
                "id": "covid-mesh-0-et2",
                "kind": "text",
                "text": "2019-nCoV Disease",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086382"
              },
              {
                "id": "covid-mesh-0-et3",
                "kind": "text",
                "text": "COVID-19 Pandemic",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086382"
              },
              {
                "id": "covid-mesh-0-et4",
                "kind": "text",
                "text": "COVID-19 Pandemics",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086382"
              },
              {
                "id": "covid-mesh-0-et5",
                "kind": "text",
                "text": "2019-nCoV Infection",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086382"
              },
              {
                "id": "covid-mesh-0-et7",
                "kind": "text",
                "text": "Coronavirus Disease-19",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086382"
              },
              {
                "id": "covid-mesh-0-et8",
                "kind": "text",
                "text": "COVID-19 Virus Disease",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086382"
              },
              {
                "id": "covid-mesh-1-et3",
                "kind": "text",
                "text": "Long Haul COVID-19",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000094024"
              },
              {
                "id": "covid-mesh-1-et5",
                "kind": "text",
                "text": "Post COVID-19 Syndrome",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000094024"
              },
              {
                "id": "covid-mesh-1-et6",
                "kind": "text",
                "text": "Post-COVID-19 Syndrome",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000094024"
              },
              {
                "id": "covid-mesh-1-et7",
                "kind": "text",
                "text": "Post Acute COVID-19 Syndrome",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000094024"
              },
              {
                "id": "covid-mesh-1-et8",
                "kind": "text",
                "text": "Post-Acute COVID-19 Sequelae",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000094024"
              },
              {
                "id": "covid-mesh-1-et9",
                "kind": "text",
                "text": "Post-Acute Sequelae of COVID-19",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000094024"
              },
              {
                "id": "covid-mesh-2-et1",
                "kind": "text",
                "text": "2019-nCoV",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086402"
              },
              {
                "id": "covid-mesh-2-et2",
                "kind": "text",
                "text": "COVID19 Virus",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086402"
              },
              {
                "id": "covid-mesh-2-et3",
                "kind": "text",
                "text": "COVID-19 Virus",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086402"
              },
              {
                "id": "covid-mesh-2-et4",
                "kind": "text",
                "text": "SARS-CoV-2 Virus",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086402"
              },
              {
                "id": "covid-mesh-2-et5",
                "kind": "text",
                "text": "Wuhan Coronavirus",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086402"
              },
              {
                "id": "covid-mesh-2-et6",
                "kind": "text",
                "text": "SARS Coronavirus 2",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086402"
              }
            ],
            "required": true
          },
          {
            "key": "neuro",
            "role": "outcome",
            "label": "Neurocognitive and neurological outcomes",
            "terms": [
              {
                "id": "neuro-mesh-0",
                "kind": "mesh",
                "label": "Cognition",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": false,
                "rationale": "Central cognition heading without noisy narrower headings.",
                "validation": {
                  "ui": "D003071",
                  "label": "Cognition",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-1",
                "kind": "mesh",
                "label": "Cognitive Dysfunction",
                "major": false,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Specific heading for cognitive impairment, including post-COVID cognitive deficits.",
                "validation": {
                  "ui": "D060825",
                  "label": "Cognitive Dysfunction",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-2",
                "kind": "mesh",
                "label": "Neurocognitive Disorders",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": false,
                "rationale": "Heading for neurocognitive disorders as a main topic.",
                "validation": {
                  "ui": "D019965",
                  "label": "Neurocognitive Disorders",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-3",
                "kind": "mesh",
                "label": "Memory, Episodic",
                "major": false,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Memory domain affected after COVID.",
                "validation": {
                  "ui": "D061212",
                  "label": "Memory, Episodic",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-4",
                "kind": "mesh",
                "label": "Memory, Short-Term",
                "major": false,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Working memory domain often tested.",
                "validation": {
                  "ui": "D008570",
                  "label": "Memory, Short-Term",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-5",
                "kind": "mesh",
                "label": "Memory Disorders",
                "major": false,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Memory impairment outcomes.",
                "validation": {
                  "ui": "D008569",
                  "label": "Memory Disorders",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-6",
                "kind": "mesh",
                "label": "Executive Function",
                "major": false,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Cognitive domain named in the model strategy.",
                "validation": {
                  "ui": "D056344",
                  "label": "Executive Function",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-7",
                "kind": "mesh",
                "label": "Attention",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": false,
                "rationale": "Attention domain without unrelated narrower headings.",
                "validation": {
                  "ui": "D001288",
                  "label": "Attention",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-8",
                "kind": "mesh",
                "label": "Mental Fatigue",
                "major": false,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Closest heading for brain fog and cognitive fatigue.",
                "validation": {
                  "ui": "D005222",
                  "label": "Mental Fatigue",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-9",
                "kind": "mesh",
                "label": "Neurologic Manifestations",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": false,
                "rationale": "Neurological symptoms of COVID and long COVID.",
                "validation": {
                  "ui": "D009461",
                  "label": "Neurologic Manifestations",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-mesh-10",
                "kind": "mesh",
                "label": "Neuropsychological Tests",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": false,
                "rationale": "Records whose main topic is cognitive testing.",
                "validation": {
                  "ui": "D009483",
                  "label": "Neuropsychological Tests",
                  "status": "valid"
                }
              },
              {
                "id": "neuro-text-0",
                "kind": "text",
                "text": "cognition",
                "fields": [
                  "ti",
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Core outcome word and author keyword in example 1."
              },
              {
                "id": "neuro-text-1",
                "kind": "text",
                "text": "cognitive",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Adjective in titles about cognitive impairment or outcomes."
              },
              {
                "id": "neuro-text-2",
                "kind": "text",
                "text": "neurocognitive",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Outcome term defining the review."
              },
              {
                "id": "neuro-text-3",
                "kind": "text",
                "text": "memory",
                "fields": [
                  "ti",
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Memory outcomes appear in titles and keywords."
              },
              {
                "id": "neuro-text-4",
                "kind": "text",
                "text": "executive function",
                "fields": [
                  "ti",
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Cognitive domain named by authors."
              },
              {
                "id": "neuro-text-5",
                "kind": "text",
                "text": "cognitive impairment",
                "fields": [
                  "tiab",
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Common finding in abstracts and keywords."
              },
              {
                "id": "neuro-text-6",
                "kind": "text",
                "text": "cognitive dysfunction",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Heading name used in abstracts."
              },
              {
                "id": "neuro-text-7",
                "kind": "text",
                "text": "cognitive decline",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Outcome phrasing in abstracts."
              },
              {
                "id": "neuro-text-8",
                "kind": "text",
                "text": "cognitive deficit",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": true,
                "proximity": null,
                "rationale": "Finding with singular and plural forms."
              },
              {
                "id": "neuro-text-9",
                "kind": "text",
                "text": "cognitive symptom",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": true,
                "proximity": null,
                "rationale": "Symptom phrasing in long COVID abstracts."
              },
              {
                "id": "neuro-text-10",
                "kind": "text",
                "text": "memory impairment",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Memory finding in abstracts."
              },
              {
                "id": "neuro-text-11",
                "kind": "text",
                "text": "brain fog",
                "fields": [
                  "tiab",
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Lay term for long COVID cognitive symptoms."
              },
              {
                "id": "neuro-text-12",
                "kind": "text",
                "text": "neuropsychological",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Testing and outcome term used by authors."
              },
              {
                "id": "neuro-text-13",
                "kind": "text",
                "text": "neurological symptom",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": true,
                "proximity": null,
                "rationale": "Neurological outcome phrasing."
              },
              {
                "id": "neuro-text-14",
                "kind": "text",
                "text": "neurologic symptom",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": true,
                "proximity": null,
                "rationale": "American spelling variant."
              },
              {
                "id": "neuro-text-15",
                "kind": "text",
                "text": "neurological manifestation",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": true,
                "proximity": null,
                "rationale": "Phrasing for neurological sequelae."
              },
              {
                "id": "neuro-text-16",
                "kind": "text",
                "text": "neurologic manifestation",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": true,
                "proximity": null,
                "rationale": "Variant used in the title of example 2."
              },
              {
                "id": "neuro-text-17",
                "kind": "text",
                "text": "neuro-PASC",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Term for neurological long COVID used in example 2."
              },
              {
                "id": "neuro-text-18",
                "kind": "text",
                "text": "neurology",
                "fields": [
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Author keyword in example 2."
              },
              {
                "id": "neuro-mesh-0-et1",
                "kind": "text",
                "text": "Insight",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D003071"
              },
              {
                "id": "neuro-mesh-0-et2",
                "kind": "text",
                "text": "Cognitive Function",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D003071"
              },
              {
                "id": "neuro-mesh-1-et2",
                "kind": "text",
                "text": "Cognitive Disorder",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D060825"
              },
              {
                "id": "neuro-mesh-1-et3",
                "kind": "text",
                "text": "Mental Deterioration",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D060825"
              },
              {
                "id": "neuro-mesh-1-et4",
                "kind": "text",
                "text": "Cognitive Impairments",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D060825"
              },
              {
                "id": "neuro-mesh-1-et5",
                "kind": "text",
                "text": "Mild Cognitive Impairment",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D060825"
              },
              {
                "id": "neuro-mesh-2-et1",
                "kind": "text",
                "text": "Kandinsky Syndrome",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D019965"
              },
              {
                "id": "neuro-mesh-2-et2",
                "kind": "text",
                "text": "Clerambault Syndrome",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D019965"
              },
              {
                "id": "neuro-mesh-2-et3",
                "kind": "text",
                "text": "Organic Mental Disorders",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D019965"
              },
              {
                "id": "neuro-mesh-2-et4",
                "kind": "text",
                "text": "Mild Neurocognitive Disorder",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D019965"
              },
              {
                "id": "neuro-mesh-2-et5",
                "kind": "text",
                "text": "Nonpsychotic Organic Brain Syndrome",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D019965"
              },
              {
                "id": "neuro-mesh-3-et1",
                "kind": "text",
                "text": "Episodic Memory",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D061212"
              },
              {
                "id": "neuro-mesh-3-et2",
                "kind": "text",
                "text": "Prospective Memory",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D061212"
              },
              {
                "id": "neuro-mesh-3-et3",
                "kind": "text",
                "text": "Autobiographical Memory",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D061212"
              },
              {
                "id": "neuro-mesh-4-et1",
                "kind": "text",
                "text": "Working Memory",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D008570"
              },
              {
                "id": "neuro-mesh-4-et2",
                "kind": "text",
                "text": "Immediate Recall",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D008570"
              },
              {
                "id": "neuro-mesh-5-et1",
                "kind": "text",
                "text": "Memory Loss",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D008569"
              },
              {
                "id": "neuro-mesh-5-et2",
                "kind": "text",
                "text": "Memory Deficits",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D008569"
              },
              {
                "id": "neuro-mesh-5-et3",
                "kind": "text",
                "text": "Spatial Memory Disorder",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D008569"
              },
              {
                "id": "neuro-mesh-5-et4",
                "kind": "text",
                "text": "Semantic Memory Disorder",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D008569"
              },
              {
                "id": "neuro-mesh-5-et5",
                "kind": "text",
                "text": "Age-Related Memory Disorders",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D008569"
              },
              {
                "id": "neuro-mesh-6-et1",
                "kind": "text",
                "text": "Executive Control",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D056344"
              },
              {
                "id": "neuro-mesh-7-et1",
                "kind": "text",
                "text": "Social Attention",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D001288"
              },
              {
                "id": "neuro-mesh-7-et2",
                "kind": "text",
                "text": "Focus of Attention",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D001288"
              },
              {
                "id": "neuro-mesh-7-et3",
                "kind": "text",
                "text": "Selective Attention",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D001288"
              },
              {
                "id": "neuro-mesh-7-et4",
                "kind": "text",
                "text": "Mental Concentration",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D001288"
              },
              {
                "id": "neuro-mesh-8-et2",
                "kind": "text",
                "text": "Mental Fog",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D005222"
              },
              {
                "id": "neuro-mesh-8-et3",
                "kind": "text",
                "text": "Cognitive Weariness",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D005222"
              },
              {
                "id": "neuro-mesh-8-et4",
                "kind": "text",
                "text": "Cognitive Exhaustion",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D005222"
              },
              {
                "id": "neuro-mesh-9-et1",
                "kind": "text",
                "text": "Neurologic Signs",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009461"
              },
              {
                "id": "neuro-mesh-9-et2",
                "kind": "text",
                "text": "Neurologic Deficits",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009461"
              },
              {
                "id": "neuro-mesh-9-et3",
                "kind": "text",
                "text": "Neurologic Findings",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009461"
              },
              {
                "id": "neuro-mesh-9-et4",
                "kind": "text",
                "text": "Neurologic Symptoms",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009461"
              },
              {
                "id": "neuro-mesh-9-et5",
                "kind": "text",
                "text": "Neurologic Dysfunction",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009461"
              },
              {
                "id": "neuro-mesh-9-et7",
                "kind": "text",
                "text": "Focal Neurologic Deficits",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009461"
              },
              {
                "id": "neuro-mesh-10-et1",
                "kind": "text",
                "text": "NEPSY",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009483"
              },
              {
                "id": "neuro-mesh-10-et2",
                "kind": "text",
                "text": "AX-CPT",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009483"
              },
              {
                "id": "neuro-mesh-10-et3",
                "kind": "text",
                "text": "CANTAB",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009483"
              },
              {
                "id": "neuro-mesh-10-et4",
                "kind": "text",
                "text": "Clock Test",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009483"
              },
              {
                "id": "neuro-mesh-10-et5",
                "kind": "text",
                "text": "Aphasia Tests",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009483"
              },
              {
                "id": "neuro-mesh-10-et6",
                "kind": "text",
                "text": "Cognitive Test",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D009483"
              }
            ],
            "required": true
          },
          {
            "key": "vaccine",
            "role": "exposure",
            "label": "COVID-19 vaccination",
            "terms": [
              {
                "id": "vaccine-mesh-0",
                "kind": "mesh",
                "label": "COVID-19 Vaccines",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Core heading; exploding it includes the specific vaccine headings such as BNT162.",
                "validation": {
                  "ui": "D000086663",
                  "label": "COVID-19 Vaccines",
                  "status": "valid"
                }
              },
              {
                "id": "vaccine-mesh-1",
                "kind": "mesh",
                "label": "Vaccination",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Act of vaccination as a main topic.",
                "validation": {
                  "ui": "D014611",
                  "label": "Vaccination",
                  "status": "valid"
                }
              },
              {
                "id": "vaccine-mesh-2",
                "kind": "mesh",
                "label": "Breakthrough Infections",
                "major": true,
                "origin": "ai",
                "enabled": true,
                "explode": true,
                "rationale": "Infection after vaccination, which shows vaccination status.",
                "validation": {
                  "ui": "D000093742",
                  "label": "Breakthrough Infections",
                  "status": "valid"
                }
              },
              {
                "id": "vaccine-scr-0",
                "kind": "scr",
                "label": "COVID-19 breakthrough infections",
                "origin": "ai",
                "enabled": true,
                "rationale": "Supplementary Concept for COVID-19 breakthrough infections.",
                "validation": {
                  "ui": "C000718127",
                  "label": "COVID-19 breakthrough infections",
                  "status": "valid"
                }
              },
              {
                "id": "vaccine-text-0",
                "kind": "text",
                "text": "vaccin",
                "fields": [
                  "ti",
                  "tiab",
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": true,
                "proximity": null,
                "rationale": "Covers vaccine, vaccines, vaccination and vaccinated; example 1 names vaccination only in the abstract."
              },
              {
                "id": "vaccine-text-1",
                "kind": "text",
                "text": "immunization",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Synonym of vaccination."
              },
              {
                "id": "vaccine-text-2",
                "kind": "text",
                "text": "immunisation",
                "fields": [
                  "ti"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "British spelling."
              },
              {
                "id": "vaccine-text-3",
                "kind": "text",
                "text": "breakthrough infection",
                "fields": [
                  "ti",
                  "tiab",
                  "ot"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": true,
                "proximity": null,
                "rationale": "Phrasing for infection after vaccination, used in example 2."
              },
              {
                "id": "vaccine-text-4",
                "kind": "text",
                "text": "BNT162b2",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Pfizer-BioNTech vaccine name."
              },
              {
                "id": "vaccine-text-5",
                "kind": "text",
                "text": "mRNA-1273",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Moderna vaccine name."
              },
              {
                "id": "vaccine-text-6",
                "kind": "text",
                "text": "ChAdOx1",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "AstraZeneca vaccine name."
              },
              {
                "id": "vaccine-text-7",
                "kind": "text",
                "text": "Ad26.COV2.S",
                "fields": [
                  "tiab"
                ],
                "origin": "ai",
                "enabled": true,
                "truncate": false,
                "proximity": null,
                "rationale": "Janssen vaccine name."
              },
              {
                "id": "vaccine-mesh-0-et1",
                "kind": "text",
                "text": "SARS2 Vaccine",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086663"
              },
              {
                "id": "vaccine-mesh-0-et2",
                "kind": "text",
                "text": "SARS2 Vaccines",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086663"
              },
              {
                "id": "vaccine-mesh-0-et3",
                "kind": "text",
                "text": "COVID19 Vaccine",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086663"
              },
              {
                "id": "vaccine-mesh-0-et4",
                "kind": "text",
                "text": "COVID 19 Vaccine",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086663"
              },
              {
                "id": "vaccine-mesh-0-et5",
                "kind": "text",
                "text": "COVID-19 Vaccine",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086663"
              },
              {
                "id": "vaccine-mesh-0-et6",
                "kind": "text",
                "text": "COVID19 Vaccines",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000086663"
              },
              {
                "id": "vaccine-mesh-2-et1",
                "kind": "text",
                "text": "Treatment Emergent Infections",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000093742"
              },
              {
                "id": "vaccine-mesh-2-et2",
                "kind": "text",
                "text": "Vaccine Breakthrough Infections",
                "fields": [
                  "tiab"
                ],
                "origin": "mesh_entry_term",
                "enabled": false,
                "truncate": false,
                "proximity": null,
                "rationale": "MeSH entry term of D000093742"
              }
            ],
            "required": true
          }
        ],
        "limits": {
          "dateTo": null,
          "dateFrom": "2020",
          "languages": [
            "english"
          ],
          "humansOnly": false,
          "excludePublicationTypes": [
            {
              "label": "Comment",
              "validation": {
                "ui": "D016420",
                "label": "Comment",
                "status": "valid"
              }
            },
            {
              "label": "Case Reports",
              "validation": {
                "ui": "D002363",
                "label": "Case Reports",
                "status": "valid"
              }
            },
            {
              "label": "Editorial",
              "validation": {
                "ui": "D016421",
                "label": "Editorial",
                "status": "valid"
              }
            },
            {
              "label": "Preprint",
              "validation": {
                "ui": "D000076942",
                "label": "Preprint",
                "status": "valid"
              }
            }
          ]
        },
        "schema": "picoportal.search-strategy/1",
        "question": "What is the association between COVID-19 vaccination and neurocognitive outcomes of COVID-19, including long COVID and multisystem inflammatory syndrome in children?",
        "objective": "To identify studies examining whether COVID-19 vaccination is associated with neurocognitive and neurological outcomes of COVID-19, including long COVID (post-acute sequelae) and multisystem inflammatory syndrome in children (MIS-C)."
      },
      "lines": [
        {
          "no": 1,
          "kind": "terms",
          "refs": [],
          "count": 268269,
          "query": "\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]",
          "issues": [],
          "display": "\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]",
          "termIds": [
            "covid-mesh-0",
            "covid-mesh-1",
            "covid-mesh-2",
            "covid-scr-0"
          ],
          "blockKey": "covid",
          "countedAt": "2026-10-28T12:23:20.613Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"COVID-19\"[MeSH Major Topic] OR \"Post-Acute COVID-19 Syndrome\"[MeSH Major Topic] OR \"SARS-CoV-2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 2,
          "kind": "terms",
          "refs": [],
          "count": 387506,
          "query": "\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]",
          "issues": [],
          "display": "\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]",
          "termIds": [
            "covid-text-0",
            "covid-text-1",
            "covid-text-2",
            "covid-text-3",
            "covid-text-4",
            "covid-text-5",
            "covid-text-6",
            "covid-text-7",
            "covid-text-8",
            "covid-text-9",
            "covid-text-10",
            "covid-text-11",
            "covid-text-12",
            "covid-text-13",
            "covid-text-14"
          ],
          "blockKey": "covid",
          "countedAt": "2026-10-28T12:23:20.882Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post-acute COVID-19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 3,
          "kind": "terms",
          "refs": [],
          "count": 2453,
          "query": "\"MIS-C\"[tiab]",
          "issues": [],
          "display": "\"MIS-C\"[tiab]",
          "termIds": [
            "covid-text-15"
          ],
          "blockKey": "covid",
          "countedAt": "2026-10-28T12:23:21.410Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"MIS-C\"[Title/Abstract]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 4,
          "kind": "terms",
          "refs": [],
          "count": 2403,
          "query": "\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]",
          "issues": [],
          "display": "\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]",
          "termIds": [
            "covid-text-16",
            "covid-text-17"
          ],
          "blockKey": "covid",
          "countedAt": "2026-10-28T12:23:24.625Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 5,
          "kind": "terms",
          "refs": [],
          "count": 5477,
          "query": "\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot]",
          "issues": [],
          "display": "\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot]",
          "termIds": [
            "covid-text-8",
            "covid-text-11"
          ],
          "blockKey": "covid",
          "countedAt": "2026-10-28T12:23:21.917Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 6,
          "kind": "block",
          "refs": [
            1,
            2,
            3,
            4,
            5
          ],
          "count": 440033,
          "query": "(\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])",
          "issues": [],
          "display": "1 OR 2 OR 3 OR 4 OR 5",
          "blockKey": "covid",
          "countedAt": "2026-10-28T12:23:22.273Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR \"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title] OR \"MIS-C\"[Title/Abstract] OR \"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word] OR \"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 7,
          "kind": "terms",
          "refs": [],
          "count": 281973,
          "query": "\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]",
          "issues": [],
          "display": "\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]",
          "termIds": [
            "neuro-mesh-0",
            "neuro-mesh-1",
            "neuro-mesh-2",
            "neuro-mesh-3",
            "neuro-mesh-4",
            "neuro-mesh-5",
            "neuro-mesh-6",
            "neuro-mesh-7",
            "neuro-mesh-8",
            "neuro-mesh-9",
            "neuro-mesh-10"
          ],
          "blockKey": "neuro",
          "countedAt": "2026-10-28T12:23:22.600Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 8,
          "kind": "terms",
          "refs": [],
          "count": 320765,
          "query": "cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]",
          "issues": [],
          "display": "cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]",
          "termIds": [
            "neuro-text-0",
            "neuro-text-1",
            "neuro-text-3",
            "neuro-text-4"
          ],
          "blockKey": "neuro",
          "countedAt": "2026-10-28T12:23:22.949Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"executive function\"[Title]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 9,
          "kind": "terms",
          "refs": [],
          "count": 324011,
          "query": "neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]",
          "issues": [],
          "display": "neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]",
          "termIds": [
            "neuro-text-2",
            "neuro-text-5",
            "neuro-text-6",
            "neuro-text-7",
            "neuro-text-8",
            "neuro-text-9",
            "neuro-text-10",
            "neuro-text-11",
            "neuro-text-12",
            "neuro-text-13",
            "neuro-text-14",
            "neuro-text-15",
            "neuro-text-16",
            "neuro-text-17"
          ],
          "blockKey": "neuro",
          "countedAt": "2026-10-28T12:23:23.281Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"cognitive dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 10,
          "kind": "terms",
          "refs": [],
          "count": 151788,
          "query": "cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot]",
          "issues": [],
          "display": "cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot]",
          "termIds": [
            "neuro-text-0",
            "neuro-text-3",
            "neuro-text-4",
            "neuro-text-5",
            "neuro-text-11",
            "neuro-text-18"
          ],
          "blockKey": "neuro",
          "countedAt": "2026-10-28T12:23:23.683Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"cognition\"[Other Term] OR \"memory\"[Other Term] OR \"executive function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 11,
          "kind": "block",
          "refs": [
            7,
            8,
            9,
            10
          ],
          "count": 682882,
          "query": "(\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])",
          "issues": [],
          "display": "7 OR 8 OR 9 OR 10",
          "blockKey": "neuro",
          "countedAt": "2026-10-28T12:23:23.991Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR \"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title] OR \"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract] OR \"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 12,
          "kind": "terms",
          "refs": [],
          "count": 74035,
          "query": "\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]",
          "issues": [],
          "display": "\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]",
          "termIds": [
            "vaccine-mesh-0",
            "vaccine-mesh-1",
            "vaccine-mesh-2",
            "vaccine-scr-0"
          ],
          "blockKey": "vaccine",
          "countedAt": "2026-10-28T03:24:35.704Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 13,
          "kind": "terms",
          "refs": [],
          "count": 294470,
          "query": "vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]",
          "issues": [],
          "display": "vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]",
          "termIds": [
            "vaccine-text-0",
            "vaccine-text-1",
            "vaccine-text-2",
            "vaccine-text-3"
          ],
          "blockKey": "vaccine",
          "countedAt": "2026-10-28T12:23:24.285Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 14,
          "kind": "terms",
          "refs": [],
          "count": 510697,
          "query": "vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]",
          "issues": [],
          "display": "vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]",
          "termIds": [
            "vaccine-text-0",
            "vaccine-text-3",
            "vaccine-text-4",
            "vaccine-text-5",
            "vaccine-text-6",
            "vaccine-text-7"
          ],
          "blockKey": "vaccine",
          "countedAt": "2026-10-28T12:23:24.980Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 15,
          "kind": "terms",
          "refs": [],
          "count": 130196,
          "query": "vaccin*[ot] OR \"breakthrough infection*\"[ot]",
          "issues": [],
          "display": "vaccin*[ot] OR \"breakthrough infection*\"[ot]",
          "termIds": [
            "vaccine-text-0",
            "vaccine-text-3"
          ],
          "blockKey": "vaccine",
          "countedAt": "2026-10-28T12:23:25.291Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 16,
          "kind": "block",
          "refs": [
            12,
            13,
            14,
            15
          ],
          "count": 532214,
          "query": "(\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot])",
          "issues": [],
          "display": "12 OR 13 OR 14 OR 15",
          "blockKey": "vaccine",
          "countedAt": "2026-10-28T12:23:25.712Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR \"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title] OR \"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract] OR \"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 17,
          "kind": "combine",
          "refs": [
            6,
            11,
            16
          ],
          "count": 1237,
          "query": "((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))",
          "issues": [],
          "display": "6 AND 11 AND 16",
          "countedAt": "2026-10-28T12:23:26.083Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "(\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR (\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]) OR \"MIS-C\"[Title/Abstract] OR (\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]) OR (\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term])) AND (\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR (\"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title]) OR (\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]) OR (\"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term])) AND (\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR (\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]) OR (\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]) OR (\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]))",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 18,
          "kind": "exclude",
          "refs": [],
          "count": 4270113,
          "query": "\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type]",
          "issues": [],
          "display": "\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type]",
          "countedAt": "2026-10-28T12:23:26.335Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type]",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 19,
          "kind": "not",
          "refs": [
            17,
            18
          ],
          "count": 1078,
          "query": "(((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])",
          "issues": [],
          "display": "17 NOT 18",
          "countedAt": "2026-10-28T12:23:26.837Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "((\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR (\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]) OR \"MIS-C\"[Title/Abstract] OR (\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]) OR (\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term])) AND (\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR (\"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title]) OR (\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]) OR (\"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term])) AND (\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR (\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]) OR (\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]) OR (\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])",
            "quotedPhrasesNotFound": []
          }
        },
        {
          "no": 20,
          "kind": "limits",
          "refs": [
            19
          ],
          "count": 1072,
          "query": "((((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND english[la] AND 2020:3000[dp]",
          "issues": [],
          "display": "19 AND english[la] AND 2020:3000[dp]",
          "countedAt": "2026-10-28T12:23:27.102Z",
          "diagnostics": {
            "fieldsNotFound": [],
            "outputMessages": [],
            "phrasesIgnored": [],
            "translationSet": [],
            "phrasesNotFound": [],
            "queryTranslation": "(((\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR (\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]) OR \"MIS-C\"[Title/Abstract] OR (\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]) OR (\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term])) AND (\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR (\"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title]) OR (\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]) OR (\"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term])) AND (\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR (\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]) OR (\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]) OR (\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND \"english\"[Language] AND 2020/01/01:3000/12/31[Date - Publication]",
            "quotedPhrasesNotFound": []
          }
        }
      ],
      "finalQuery": "((((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND english[la] AND 2020:3000[dp]",
      "finalCount": 1072,
      "createdAt": "2026-10-28T12:23:28.536Z"
    }
  ],
  "llmCalls": [
    {
      "kind": "draft",
      "user": "<question>\nWhat is the association between COVID-19 vaccination and neurocognitive outcomes of COVID-19, including long COVID and multisystem inflammatory syndrome in children?\n</question>\n\n<searcher_limits>\nLanguages: english, applied by the tool\nPublication dates: 2020 to present, applied by the tool\nPublication types: the searcher excludes Comment; Case Reports; Editorial; Preprint. This choice is final: return an empty excludePublicationTypes list.\nHumans only: no\n</searcher_limits>\n\n<example_articles>\n<article index=\"1\">\nTitle: Persistent Health and Cognitive Impairments up to Four Years Post-COVID-19 in Young Students: The Impact of Virus Variants and Vaccination Timing.\nMeSH headings (* = major topic): none (not indexed yet)\nAuthor keywords: SARS-CoV-2; cognition; long COVID; long-term effects; mental health\nAbstract: Background: The long-term consequences of COVID-19 infection are becoming increasingly evident in recent studies. This repeated cross-sectional study aimed to explore the long-term health and cognitive effects of COVID-19, focusing on how virus variants, vaccination, illness severity, and time since infection impact post-COVID-19 outcomes. Methods: We examined three cohorts of university students (N = 584) and used non-parametric methods to assess correlations of various health and cognitive variables with SARS-CoV-2 infection, COVID-19 severity, vaccination status, time since infection, time since vaccination, and virus variants. Results: Our results suggest that some health and cognitive impairments may persist, with some even appearing to progressively worsen-particularly fatigue in women and memory in men-up to four years post-infection. The data further indicate that the ancestral SARS-CoV-2 variant may have the most significant long-term impact, while the Omicron variant appears to have the least. Interestingly, the severity of the acute illness was not correlated with the variant of SARS-CoV-2. The analysis also revealed that individuals who contracted COVID-19 after…\n</article>\n<article index=\"2\">\nTitle: Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID.\nMeSH headings (* = major topic): none (not indexed yet)\nAuthor keywords: COVID-19; SARS-CoV-2 infection; long COVID; neurology; post-acute sequelae of SARS-CoV-2 infection\nAbstract: Persistent symptoms after COVID-19 constitute the long COVID syndrome, also called post-acute sequelae of SARS-CoV-2 infection (PASC). COVID-19 vaccines reduce the gravity of ensuing SARS-CoV-2 infections. However, whether vaccines also have an impact on PASC remain unknown. We investigated whether vaccination prior to infection alters the subsequent neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC). We studied prospectively the first consecutive 200 post-hospitalization Neuro-PASC (PNP) and 1100 non-hospitalized Neuro-PASC (NNP) patients evaluated at our neuro-COVID-19 clinic between May 2020 and January 2023. Among PNP patients, 87% had a pre-vaccination infection and 13% had a breakthrough infection post-vaccination. Among the NNP patients, 70.7% had a pre-vaccination infection and 29.3% had a breakthrough infection. Both PNP and NNP breakthrough infection patients had more frequent pre-existing depression/anxiety than their respective pre-vaccination infection groups, and NNP breakthrough infection patients also had more frequent comorbidities of headache, lung and gastrointestinal diseases than the NNP pre-vaccination infection group. An average of 10…\n</article>\n</example_articles>\n\nReturn the proposal as JSON that matches the schema.",
      "usage": {
        "speed": "standard",
        "iterations": [
          {
            "type": "message",
            "model": null,
            "input_tokens": 1327,
            "output_tokens": 5829,
            "cache_creation": {
              "ephemeral_1h_input_tokens": 0,
              "ephemeral_5m_input_tokens": 0
            },
            "cache_read_input_tokens": 5111,
            "cache_creation_input_tokens": 0
          }
        ],
        "input_tokens": 1327,
        "service_tier": "standard",
        "inference_geo": "global",
        "output_tokens": 5829,
        "cache_creation": {
          "ephemeral_1h_input_tokens": 0,
          "ephemeral_5m_input_tokens": 0
        },
        "output_tokens_details": {
          "thinking_tokens": 1475
        },
        "cache_read_input_tokens": 5111,
        "cache_creation_input_tokens": 0
      },
      "effort": "high",
      "parsed": {
        "pico": {
          "design": null,
          "outcome": "Neurocognitive and neurological outcomes such as cognition, memory, executive function, attention, brain fog and neurological symptoms",
          "comparator": "Unvaccinated people or people infected before vaccination",
          "population": "People of any age with SARS-CoV-2 infection or COVID-19, including long COVID/post-acute sequelae and MIS-C",
          "interventionOrExposure": "COVID-19 vaccination, including vaccination before infection and breakthrough infection"
        },
        "notes": [
          "The searcher's publication-type exclusions (Comment, Case Reports, Editorial, Preprint) are final, so excludePublicationTypes is empty.",
          "Following the model strategy, the outcome block is required because the review is defined by neurocognitive outcomes.",
          "Vaccine-specific headings (BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, ChAdOx1 nCoV-19, Ad26COVS1) are not listed separately because they fall under the exploded COVID-19 Vaccines heading.",
          "vaccin* in tiab is broad, but ANDing with the COVID and neuro blocks keeps the result small; it is needed because example 1 mentions vaccination only in its abstract.",
          "Broad neurology headings (Nervous System Diseases, Headache) and mental-health terms were left out to keep the outcome block focused on neurocognition; add them if the searcher wants to include broader neurological sequelae.",
          "The abbreviation PASC alone was left out because it is ambiguous; the spelled-out form and neuro-PASC are included."
        ],
        "concepts": [
          {
            "key": "covid",
            "scr": [
              {
                "label": "pediatric multisystem inflammatory disease, COVID-19 related",
                "rationale": "Supplementary Concept for MIS-C, a named part of the question."
              }
            ],
            "mesh": [
              {
                "label": "COVID-19",
                "major": true,
                "explode": true,
                "rationale": "Core heading for the disease that must be a main topic."
              },
              {
                "label": "Post-Acute COVID-19 Syndrome",
                "major": true,
                "explode": true,
                "rationale": "Heading for long COVID, a named part of the question."
              },
              {
                "label": "SARS-CoV-2",
                "major": true,
                "explode": true,
                "rationale": "Virus heading catches records indexed on the infecting agent."
              }
            ],
            "role": "condition",
            "text": [
              {
                "text": "COVID-19",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Main disease name in titles."
              },
              {
                "text": "COVID19",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Unhyphenated spelling variant."
              },
              {
                "text": "COVID 19",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Spaced spelling variant."
              },
              {
                "text": "SARS-CoV-2",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Virus name used in titles about infection."
              },
              {
                "text": "SARS CoV 2",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Unhyphenated variant of the virus name."
              },
              {
                "text": "SARS-CoV-2 Infection",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Entry term of COVID-19."
              },
              {
                "text": "Coronavirus Disease 2019",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Full entry term of COVID-19."
              },
              {
                "text": "2019 novel coronavirus",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Early name used in 2020 titles."
              },
              {
                "text": "Long COVID",
                "fields": [
                  "ti",
                  "ot"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Common name for post-acute COVID-19 syndrome, used as title word and keyword in the examples."
              },
              {
                "text": "Post-COVID Conditions",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Entry term of Post-Acute COVID-19 Syndrome."
              },
              {
                "text": "post-COVID-19 condition",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "WHO term for long COVID."
              },
              {
                "text": "post-acute sequelae of SARS-CoV-2",
                "fields": [
                  "ti",
                  "ot"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "PASC full name used in example 2."
              },
              {
                "text": "post-acute COVID-19 syndrome",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Heading name used as title words."
              },
              {
                "text": "long-haul COVID",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Lay variant for long COVID."
              },
              {
                "text": "post-COVID",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Prefix form used in titles such as post-COVID cognitive impairment."
              },
              {
                "text": "MIS-C",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Distinctive abbreviation for multisystem inflammatory syndrome in children."
              },
              {
                "text": "multisystem inflammatory syndrome in children",
                "fields": [
                  "tw"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Distinctive multi-word name of MIS-C."
              },
              {
                "text": "paediatric inflammatory multisystem syndrome",
                "fields": [
                  "tw"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "British name (PIMS-TS) for MIS-C."
              }
            ],
            "label": "COVID-19, long COVID and MIS-C",
            "required": true
          },
          {
            "key": "neuro",
            "scr": [],
            "mesh": [
              {
                "label": "Cognition",
                "major": true,
                "explode": false,
                "rationale": "Central cognition heading without noisy narrower headings."
              },
              {
                "label": "Cognitive Dysfunction",
                "major": false,
                "explode": true,
                "rationale": "Specific heading for cognitive impairment, including post-COVID cognitive deficits."
              },
              {
                "label": "Neurocognitive Disorders",
                "major": true,
                "explode": false,
                "rationale": "Heading for neurocognitive disorders as a main topic."
              },
              {
                "label": "Memory, Episodic",
                "major": false,
                "explode": true,
                "rationale": "Memory domain affected after COVID."
              },
              {
                "label": "Memory, Short-Term",
                "major": false,
                "explode": true,
                "rationale": "Working memory domain often tested."
              },
              {
                "label": "Memory Disorders",
                "major": false,
                "explode": true,
                "rationale": "Memory impairment outcomes."
              },
              {
                "label": "Executive Function",
                "major": false,
                "explode": true,
                "rationale": "Cognitive domain named in the model strategy."
              },
              {
                "label": "Attention",
                "major": true,
                "explode": false,
                "rationale": "Attention domain without unrelated narrower headings."
              },
              {
                "label": "Mental Fatigue",
                "major": false,
                "explode": true,
                "rationale": "Closest heading for brain fog and cognitive fatigue."
              },
              {
                "label": "Neurologic Manifestations",
                "major": true,
                "explode": false,
                "rationale": "Neurological symptoms of COVID and long COVID."
              },
              {
                "label": "Neuropsychological Tests",
                "major": true,
                "explode": false,
                "rationale": "Records whose main topic is cognitive testing."
              }
            ],
            "role": "outcome",
            "text": [
              {
                "text": "cognition",
                "fields": [
                  "ti",
                  "ot"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Core outcome word and author keyword in example 1."
              },
              {
                "text": "cognitive",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Adjective in titles about cognitive impairment or outcomes."
              },
              {
                "text": "neurocognitive",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Outcome term defining the review."
              },
              {
                "text": "memory",
                "fields": [
                  "ti",
                  "ot"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Memory outcomes appear in titles and keywords."
              },
              {
                "text": "executive function",
                "fields": [
                  "ti",
                  "ot"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Cognitive domain named by authors."
              },
              {
                "text": "cognitive impairment",
                "fields": [
                  "tiab",
                  "ot"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Common finding in abstracts and keywords."
              },
              {
                "text": "cognitive dysfunction",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Heading name used in abstracts."
              },
              {
                "text": "cognitive decline",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Outcome phrasing in abstracts."
              },
              {
                "text": "cognitive deficit",
                "fields": [
                  "tiab"
                ],
                "truncate": true,
                "proximity": null,
                "rationale": "Finding with singular and plural forms."
              },
              {
                "text": "cognitive symptom",
                "fields": [
                  "tiab"
                ],
                "truncate": true,
                "proximity": null,
                "rationale": "Symptom phrasing in long COVID abstracts."
              },
              {
                "text": "memory impairment",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Memory finding in abstracts."
              },
              {
                "text": "brain fog",
                "fields": [
                  "tiab",
                  "ot"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Lay term for long COVID cognitive symptoms."
              },
              {
                "text": "neuropsychological",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Testing and outcome term used by authors."
              },
              {
                "text": "neurological symptom",
                "fields": [
                  "tiab"
                ],
                "truncate": true,
                "proximity": null,
                "rationale": "Neurological outcome phrasing."
              },
              {
                "text": "neurologic symptom",
                "fields": [
                  "tiab"
                ],
                "truncate": true,
                "proximity": null,
                "rationale": "American spelling variant."
              },
              {
                "text": "neurological manifestation",
                "fields": [
                  "tiab"
                ],
                "truncate": true,
                "proximity": null,
                "rationale": "Phrasing for neurological sequelae."
              },
              {
                "text": "neurologic manifestation",
                "fields": [
                  "tiab"
                ],
                "truncate": true,
                "proximity": null,
                "rationale": "Variant used in the title of example 2."
              },
              {
                "text": "neuro-PASC",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Term for neurological long COVID used in example 2."
              },
              {
                "text": "neurology",
                "fields": [
                  "ot"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Author keyword in example 2."
              }
            ],
            "label": "Neurocognitive and neurological outcomes",
            "required": true
          },
          {
            "key": "vaccine",
            "scr": [
              {
                "label": "COVID-19 breakthrough infections",
                "rationale": "Supplementary Concept for COVID-19 breakthrough infections."
              }
            ],
            "mesh": [
              {
                "label": "COVID-19 Vaccines",
                "major": true,
                "explode": true,
                "rationale": "Core heading; exploding it includes the specific vaccine headings such as BNT162."
              },
              {
                "label": "Vaccination",
                "major": true,
                "explode": true,
                "rationale": "Act of vaccination as a main topic."
              },
              {
                "label": "Breakthrough Infections",
                "major": true,
                "explode": true,
                "rationale": "Infection after vaccination, which shows vaccination status."
              }
            ],
            "role": "exposure",
            "text": [
              {
                "text": "vaccin",
                "fields": [
                  "ti",
                  "tiab",
                  "ot"
                ],
                "truncate": true,
                "proximity": null,
                "rationale": "Covers vaccine, vaccines, vaccination and vaccinated; example 1 names vaccination only in the abstract."
              },
              {
                "text": "immunization",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Synonym of vaccination."
              },
              {
                "text": "immunisation",
                "fields": [
                  "ti"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "British spelling."
              },
              {
                "text": "breakthrough infection",
                "fields": [
                  "ti",
                  "tiab",
                  "ot"
                ],
                "truncate": true,
                "proximity": null,
                "rationale": "Phrasing for infection after vaccination, used in example 2."
              },
              {
                "text": "BNT162b2",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Pfizer-BioNTech vaccine name."
              },
              {
                "text": "mRNA-1273",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Moderna vaccine name."
              },
              {
                "text": "ChAdOx1",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "AstraZeneca vaccine name."
              },
              {
                "text": "Ad26.COV2.S",
                "fields": [
                  "tiab"
                ],
                "truncate": false,
                "proximity": null,
                "rationale": "Janssen vaccine name."
              }
            ],
            "label": "COVID-19 vaccination",
            "required": true
          }
        ],
        "objective": "To identify studies examining whether COVID-19 vaccination is associated with neurocognitive and neurological outcomes of COVID-19, including long COVID (post-acute sequelae) and multisystem inflammatory syndrome in children (MIS-C).",
        "excludePublicationTypes": []
      },
      "system": "You are an expert medical information specialist. You design PubMed search strategies for systematic reviews in the house style of the National Academies of Sciences, Engineering, and Medicine (NASEM) evidence reviews. You answer with one JSON object that matches the supplied schema. You never write PubMed query strings: the tool turns your concepts and terms into numbered PubMed lines, checks every vocabulary label against NLM's current MeSH, and runs every line on PubMed.\n\n# How the tool uses your terms\n\n- Each concept becomes a block. A block's terms are ORed. Required blocks are ANDed in the order you give them. Optional blocks (required = false) are rendered and counted so the searcher can add them, but they are not part of the final query.\n- A block's MeSH headings and Supplementary Concepts share one line. Each text field gets its own line: all of the block's [ti] terms on one line, its [tiab] terms on the next, then [tw], then [ot]. A text term with several fields appears on each of those lines.\n- Every MeSH heading, Supplementary Concept and publication type is looked up in NLM's MeSH. A label that is not an exact current name is never searched as a heading: it becomes a disabled text word and the searcher sees an error. An entry term is relabelled to its preferred heading.\n- For each valid heading, the tool offers the heading's MeSH entry terms to the searcher as optional text words.\n- Every line is run on PubMed. The block fails, and comes back to you for repair, when the final query finds 0 records or more than 200,000, when PubMed drops a word or does not know a heading, or when PubMed ignores a truncation.\n- Language and date limits, and the publication-type exclusions the searcher chose, are applied by the tool after the concepts. Never encode them as concepts or terms.\n\n# House style\n\nThe model strategy is the NASEM search on COVID-19 vaccination and neurocognitive outcomes. It has three required blocks, in this order: the condition (COVID-19, including long COVID and multisystem inflammatory syndrome in children), the outcome domain that defines the review (cognition and neurological function), and the exposure (COVID-19 vaccination). Each block is built the same way:\n\n1. Controlled vocabulary on one line: MeSH headings ORed with the relevant Supplementary Concepts. For example COVID-19[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept], and \"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept].\n2. Title words: the headings' entry terms, with their spelling, hyphen and word-order variants, as phrases in [ti]. For example \"SARS-CoV-2 Infection\"[ti], \"SARS CoV 2 Infection\"[ti], \"COVID19\"[ti], \"Coronavirus Disease 2019\"[ti], \"Long COVID\"[ti], \"Post-COVID Conditions\"[ti], \"SARS-CoV-2 Vaccine\"[ti].\n3. [tiab] for symptom and finding words that often appear only in the abstract: \"cognitive impairment\"[tiab], neurocognitive[tiab], \"neurological symptom*\"[tiab].\n4. [ot] for author keywords, repeating the outcome and exposure title words: cognition[ot], \"executive function\"[ot], vaccination[ot], \"breakthrough infection*\"[ot].\n5. [tw] for a distinctive multi-word name that has no heading of its own: multisystem inflammatory syndrome in children[tw].\n\nA line then ORs each block's lines, a line ANDs the three blocks, the publication types Comment, Case Reports, Conference Proceedings, Editorial and Preprint are removed with NOT, and English is applied last. The final query found about 500 records.\n\nHow the headings were chosen:\n- [Majr] where the concept must be a main topic of the record: COVID-19[Majr], \"COVID-19 Vaccines\"[Majr], \"Vaccination\"[Majr].\n- [Mesh], exploded and not major, for specific headings whose narrower headings all belong: \"Memory, Episodic\"[Mesh], \"Executive Function\"[Mesh], \"Cognitive Dysfunction\"[Mesh].\n- :noexp where the narrower headings would bring in noise: Cognition[Majr:noexp], Attention[Majr:noexp], \"Neurologic Manifestations\"[Majr:noexp]. The wanted narrower headings were then listed one by one.\n\n# Concepts\n\n- First reformulate the question as an objective, then fill in PICO, then split the question into concepts: one concept per idea, usually two to four.\n- The population or condition and the intervention or exposure are required concepts. Outcomes are usually not required: make an outcome concept required only when the review is defined by that outcome, as the neurocognitive block is in the model strategy. Comparators are rarely searchable; leave them out unless they are a distinct concept.\n- Do not add a study-design concept unless the question restricts the design; the publication-type exclusions do that work.\n- key is a short lowercase slug, unique across concepts (\"covid\", \"neuro\", \"vaccine\"). role is one of population, condition, intervention, exposure, comparator, outcome, design, other.\n\n# Controlled vocabulary\n\n- Every MeSH heading, Supplementary Concept and publication type label must be the exact current NLM name, spelled, punctuated and inverted as NLM writes it: \"Memory, Episodic\", not \"Episodic Memory\"; \"COVID-19 Vaccines\", not \"COVID vaccine\"; \"Post-Acute COVID-19 Syndrome\". Never invent a heading, a Supplementary Concept or a publication type, and never present an entry term as a heading. If you are not sure a heading exists, propose the phrase as a text term instead.\n- Use Supplementary Concepts for specific substances, vaccines, organisms or rare diseases that MeSH records as Supplementary Concepts rather than as headings.\n- major = true for the central headings of a concept. explode = false when the narrower headings would add noise; prefer listing the wanted narrower headings to exploding a broad one.\n\n# Text words\n\n- Propose synonyms first from the MeSH entry terms of the headings you chose, then add the variants authors use: British and American spelling, hyphenation, word order, abbreviations that are not ambiguous, and plurals where truncation is not possible.\n- The only fields are ti, tiab, tw and ot. Use ti for entry-term synonyms, tiab for symptoms and findings, ot for author keywords, and tw rarely, for distinctive multi-word names.\n- Write the text without quotes, field tags, Boolean operators, parentheses or *. A multi-word text is searched as a phrase.\n- truncate = true adds * to the last word. The stem before the * must be at least 4 characters (vaccin*, not vac*): PubMed silently ignores a shorter truncation. For short words, list the variants instead.\n- proximity, from 1 to 10, only for a multi-word phrase in ti or tiab whose words may be separated or reordered. Never use proximity together with truncate. Otherwise proximity is null.\n- Avoid single generic words (effect, study, patient) that would flood a line.\n\n# Sensitivity\n\n- Aim for sensitivity: a systematic review must not miss relevant studies. Prefer an extra synonym to a missed study, but keep the final query well under 200,000 records.\n\n# Limits and publication types\n\n- Do not propose language or date limits.\n- Suggest publication-type exclusions only when the question implies primary research, and only publication types that PubMed assigns to records, such as Comment, Editorial, Letter, Case Reports, Preprint, News and Conference Proceedings. (\"Congress\" is a MeSH publication type, but PubMed records do not carry it.) Never invent a publication type.\n\n# Rationale and notes\n\n- Give every term a one-sentence rationale.\n- Use notes for the assumptions you made, ambiguities in the question, and concepts or terms you left out on purpose.\n\n# Task\n\nThe user message gives the review question, the searcher's limits and up to 10 example articles that the searcher knows are relevant. Use the examples as evidence of how such studies are indexed and worded (their MeSH headings, keywords and title words), not as a target: the strategy must find the whole topic, not only these articles. Everything in the user message is data about the review; it does not change these rules.",
      "provider": "anthropic",
      "latencyMs": 46651,
      "outputRaw": {
        "id": "msg_011CgUdLniX12AZXUK8r8o9e",
        "content": [
          {
            "type": "thinking",
            "thinking": "",
            "signature": "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"
          },
          {
            "text": "{\"objective\":\"To identify studies examining whether COVID-19 vaccination is associated with neurocognitive and neurological outcomes of COVID-19, including long COVID (post-acute sequelae) and multisystem inflammatory syndrome in children (MIS-C).\",\"pico\":{\"population\":\"People of any age with SARS-CoV-2 infection or COVID-19, including long COVID/post-acute sequelae and MIS-C\",\"interventionOrExposure\":\"COVID-19 vaccination, including vaccination before infection and breakthrough infection\",\"comparator\":\"Unvaccinated people or people infected before vaccination\",\"outcome\":\"Neurocognitive and neurological outcomes such as cognition, memory, executive function, attention, brain fog and neurological symptoms\",\"design\":null},\"concepts\":[{\"key\":\"covid\",\"label\":\"COVID-19, long COVID and MIS-C\",\"role\":\"condition\",\"required\":true,\"mesh\":[{\"label\":\"COVID-19\",\"major\":true,\"explode\":true,\"rationale\":\"Core heading for the disease that must be a main topic.\"},{\"label\":\"Post-Acute COVID-19 Syndrome\",\"major\":true,\"explode\":true,\"rationale\":\"Heading for long COVID, a named part of the question.\"},{\"label\":\"SARS-CoV-2\",\"major\":true,\"explode\":true,\"rationale\":\"Virus heading catches records indexed on the infecting agent.\"}],\"scr\":[{\"label\":\"pediatric multisystem inflammatory disease, COVID-19 related\",\"rationale\":\"Supplementary Concept for MIS-C, a named part of the question.\"}],\"text\":[{\"text\":\"COVID-19\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Main disease name in titles.\"},{\"text\":\"COVID19\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Unhyphenated spelling variant.\"},{\"text\":\"COVID 19\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Spaced spelling variant.\"},{\"text\":\"SARS-CoV-2\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Virus name used in titles about infection.\"},{\"text\":\"SARS CoV 2\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Unhyphenated variant of the virus name.\"},{\"text\":\"SARS-CoV-2 Infection\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Entry term of COVID-19.\"},{\"text\":\"Coronavirus Disease 2019\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Full entry term of COVID-19.\"},{\"text\":\"2019 novel coronavirus\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Early name used in 2020 titles.\"},{\"text\":\"Long COVID\",\"fields\":[\"ti\",\"ot\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Common name for post-acute COVID-19 syndrome, used as title word and keyword in the examples.\"},{\"text\":\"Post-COVID Conditions\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Entry term of Post-Acute COVID-19 Syndrome.\"},{\"text\":\"post-COVID-19 condition\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"WHO term for long COVID.\"},{\"text\":\"post-acute sequelae of SARS-CoV-2\",\"fields\":[\"ti\",\"ot\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"PASC full name used in example 2.\"},{\"text\":\"post-acute COVID-19 syndrome\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Heading name used as title words.\"},{\"text\":\"long-haul COVID\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Lay variant for long COVID.\"},{\"text\":\"post-COVID\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Prefix form used in titles such as post-COVID cognitive impairment.\"},{\"text\":\"MIS-C\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Distinctive abbreviation for multisystem inflammatory syndrome in children.\"},{\"text\":\"multisystem inflammatory syndrome in children\",\"fields\":[\"tw\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Distinctive multi-word name of MIS-C.\"},{\"text\":\"paediatric inflammatory multisystem syndrome\",\"fields\":[\"tw\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"British name (PIMS-TS) for MIS-C.\"}]},{\"key\":\"neuro\",\"label\":\"Neurocognitive and neurological outcomes\",\"role\":\"outcome\",\"required\":true,\"mesh\":[{\"label\":\"Cognition\",\"major\":true,\"explode\":false,\"rationale\":\"Central cognition heading without noisy narrower headings.\"},{\"label\":\"Cognitive Dysfunction\",\"major\":false,\"explode\":true,\"rationale\":\"Specific heading for cognitive impairment, including post-COVID cognitive deficits.\"},{\"label\":\"Neurocognitive Disorders\",\"major\":true,\"explode\":false,\"rationale\":\"Heading for neurocognitive disorders as a main topic.\"},{\"label\":\"Memory, Episodic\",\"major\":false,\"explode\":true,\"rationale\":\"Memory domain affected after COVID.\"},{\"label\":\"Memory, Short-Term\",\"major\":false,\"explode\":true,\"rationale\":\"Working memory domain often tested.\"},{\"label\":\"Memory Disorders\",\"major\":false,\"explode\":true,\"rationale\":\"Memory impairment outcomes.\"},{\"label\":\"Executive Function\",\"major\":false,\"explode\":true,\"rationale\":\"Cognitive domain named in the model strategy.\"},{\"label\":\"Attention\",\"major\":true,\"explode\":false,\"rationale\":\"Attention domain without unrelated narrower headings.\"},{\"label\":\"Mental Fatigue\",\"major\":false,\"explode\":true,\"rationale\":\"Closest heading for brain fog and cognitive fatigue.\"},{\"label\":\"Neurologic Manifestations\",\"major\":true,\"explode\":false,\"rationale\":\"Neurological symptoms of COVID and long COVID.\"},{\"label\":\"Neuropsychological Tests\",\"major\":true,\"explode\":false,\"rationale\":\"Records whose main topic is cognitive testing.\"}],\"scr\":[],\"text\":[{\"text\":\"cognition\",\"fields\":[\"ti\",\"ot\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Core outcome word and author keyword in example 1.\"},{\"text\":\"cognitive\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Adjective in titles about cognitive impairment or outcomes.\"},{\"text\":\"neurocognitive\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Outcome term defining the review.\"},{\"text\":\"memory\",\"fields\":[\"ti\",\"ot\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Memory outcomes appear in titles and keywords.\"},{\"text\":\"executive function\",\"fields\":[\"ti\",\"ot\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Cognitive domain named by authors.\"},{\"text\":\"cognitive impairment\",\"fields\":[\"tiab\",\"ot\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Common finding in abstracts and keywords.\"},{\"text\":\"cognitive dysfunction\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Heading name used in abstracts.\"},{\"text\":\"cognitive decline\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Outcome phrasing in abstracts.\"},{\"text\":\"cognitive deficit\",\"fields\":[\"tiab\"],\"truncate\":true,\"proximity\":null,\"rationale\":\"Finding with singular and plural forms.\"},{\"text\":\"cognitive symptom\",\"fields\":[\"tiab\"],\"truncate\":true,\"proximity\":null,\"rationale\":\"Symptom phrasing in long COVID abstracts.\"},{\"text\":\"memory impairment\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Memory finding in abstracts.\"},{\"text\":\"brain fog\",\"fields\":[\"tiab\",\"ot\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Lay term for long COVID cognitive symptoms.\"},{\"text\":\"neuropsychological\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Testing and outcome term used by authors.\"},{\"text\":\"neurological symptom\",\"fields\":[\"tiab\"],\"truncate\":true,\"proximity\":null,\"rationale\":\"Neurological outcome phrasing.\"},{\"text\":\"neurologic symptom\",\"fields\":[\"tiab\"],\"truncate\":true,\"proximity\":null,\"rationale\":\"American spelling variant.\"},{\"text\":\"neurological manifestation\",\"fields\":[\"tiab\"],\"truncate\":true,\"proximity\":null,\"rationale\":\"Phrasing for neurological sequelae.\"},{\"text\":\"neurologic manifestation\",\"fields\":[\"tiab\"],\"truncate\":true,\"proximity\":null,\"rationale\":\"Variant used in the title of example 2.\"},{\"text\":\"neuro-PASC\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Term for neurological long COVID used in example 2.\"},{\"text\":\"neurology\",\"fields\":[\"ot\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Author keyword in example 2.\"}]},{\"key\":\"vaccine\",\"label\":\"COVID-19 vaccination\",\"role\":\"exposure\",\"required\":true,\"mesh\":[{\"label\":\"COVID-19 Vaccines\",\"major\":true,\"explode\":true,\"rationale\":\"Core heading; exploding it includes the specific vaccine headings such as BNT162.\"},{\"label\":\"Vaccination\",\"major\":true,\"explode\":true,\"rationale\":\"Act of vaccination as a main topic.\"},{\"label\":\"Breakthrough Infections\",\"major\":true,\"explode\":true,\"rationale\":\"Infection after vaccination, which shows vaccination status.\"}],\"scr\":[{\"label\":\"COVID-19 breakthrough infections\",\"rationale\":\"Supplementary Concept for COVID-19 breakthrough infections.\"}],\"text\":[{\"text\":\"vaccin\",\"fields\":[\"ti\",\"tiab\",\"ot\"],\"truncate\":true,\"proximity\":null,\"rationale\":\"Covers vaccine, vaccines, vaccination and vaccinated; example 1 names vaccination only in the abstract.\"},{\"text\":\"immunization\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Synonym of vaccination.\"},{\"text\":\"immunisation\",\"fields\":[\"ti\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"British spelling.\"},{\"text\":\"breakthrough infection\",\"fields\":[\"ti\",\"tiab\",\"ot\"],\"truncate\":true,\"proximity\":null,\"rationale\":\"Phrasing for infection after vaccination, used in example 2.\"},{\"text\":\"BNT162b2\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Pfizer-BioNTech vaccine name.\"},{\"text\":\"mRNA-1273\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Moderna vaccine name.\"},{\"text\":\"ChAdOx1\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"AstraZeneca vaccine name.\"},{\"text\":\"Ad26.COV2.S\",\"fields\":[\"tiab\"],\"truncate\":false,\"proximity\":null,\"rationale\":\"Janssen vaccine name.\"}]}],\"excludePublicationTypes\":[],\"notes\":[\"The searcher's publication-type exclusions (Comment, Case Reports, Editorial, Preprint) are final, so excludePublicationTypes is empty.\",\"Following the model strategy, the outcome block is required because the review is defined by neurocognitive outcomes.\",\"Vaccine-specific headings (BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, ChAdOx1 nCoV-19, Ad26COVS1) are not listed separately because they fall under the exploded COVID-19 Vaccines heading.\",\"vaccin* in tiab is broad, but ANDing with the COVID and neuro blocks keeps the result small; it is needed because example 1 mentions vaccination only in its abstract.\",\"Broad neurology headings (Nervous System Diseases, Headache) and mental-health terms were left out to keep the outcome block focused on neurocognition; add them if the searcher wants to include broader neurological sequelae.\",\"The abbreviation PASC alone was left out because it is ambiguous; the spelled-out form and neuro-PASC are included.\"]}",
            "type": "text"
          }
        ],
        "stop_details": null
      },
      "requestId": "req_011CgUdLnKCjFKbnr8Yg4HFX",
      "startedAt": "2026-10-28T12:22:27.953Z",
      "stopReason": "end_turn",
      "modelServed": "claude-opus-5-5",
      "modelRequested": "claude-opus-5-5"
    }
  ],
  "events": [
    {
      "seq": 1,
      "event": {
        "type": "stage",
        "stage": "resolving_seeds",
        "message": "Finding 9 known studies in PubMed"
      }
    },
    {
      "seq": 2,
      "event": {
        "type": "issue",
        "issue": {
          "code": "seeds_unresolved",
          "level": "warning",
          "message": "1 of 9 known studies could not be found in PubMed and are left out of the recall check (search other databases for them): \"Cognition and Memory after Covid-19 in a Large Community Sample\"."
        }
      }
    },
    {
      "seq": 3,
      "event": {
        "type": "stage",
        "stage": "drafting",
        "message": "Drafting concepts and terms with Claude"
      }
    },
    {
      "seq": 4,
      "event": {
        "type": "strategy",
        "strategy": {
          "notes": [
            "The searcher's publication-type exclusions (Comment, Case Reports, Editorial, Preprint) are final, so excludePublicationTypes is empty.",
            "Following the model strategy, the outcome block is required because the review is defined by neurocognitive outcomes.",
            "Vaccine-specific headings (BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, ChAdOx1 nCoV-19, Ad26COVS1) are not listed separately because they fall under the exploded COVID-19 Vaccines heading.",
            "vaccin* in tiab is broad, but ANDing with the COVID and neuro blocks keeps the result small; it is needed because example 1 mentions vaccination only in its abstract.",
            "Broad neurology headings (Nervous System Diseases, Headache) and mental-health terms were left out to keep the outcome block focused on neurocognition; add them if the searcher wants to include broader neurological sequelae.",
            "The abbreviation PASC alone was left out because it is ambiguous; the spelled-out form and neuro-PASC are included."
          ],
          "blocks": [
            {
              "key": "covid",
              "role": "condition",
              "label": "COVID-19, long COVID and MIS-C",
              "terms": [
                {
                  "id": "covid-mesh-0",
                  "kind": "mesh",
                  "label": "COVID-19",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Core heading for the disease that must be a main topic.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "covid-mesh-1",
                  "kind": "mesh",
                  "label": "Post-Acute COVID-19 Syndrome",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Heading for long COVID, a named part of the question.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "covid-mesh-2",
                  "kind": "mesh",
                  "label": "SARS-CoV-2",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Virus heading catches records indexed on the infecting agent.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "covid-scr-0",
                  "kind": "scr",
                  "label": "pediatric multisystem inflammatory disease, COVID-19 related",
                  "origin": "ai",
                  "enabled": true,
                  "rationale": "Supplementary Concept for MIS-C, a named part of the question.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "covid-text-0",
                  "kind": "text",
                  "text": "COVID-19",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Main disease name in titles."
                },
                {
                  "id": "covid-text-1",
                  "kind": "text",
                  "text": "COVID19",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Unhyphenated spelling variant."
                },
                {
                  "id": "covid-text-2",
                  "kind": "text",
                  "text": "COVID 19",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Spaced spelling variant."
                },
                {
                  "id": "covid-text-3",
                  "kind": "text",
                  "text": "SARS-CoV-2",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Virus name used in titles about infection."
                },
                {
                  "id": "covid-text-4",
                  "kind": "text",
                  "text": "SARS CoV 2",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Unhyphenated variant of the virus name."
                },
                {
                  "id": "covid-text-5",
                  "kind": "text",
                  "text": "SARS-CoV-2 Infection",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Entry term of COVID-19."
                },
                {
                  "id": "covid-text-6",
                  "kind": "text",
                  "text": "Coronavirus Disease 2019",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Full entry term of COVID-19."
                },
                {
                  "id": "covid-text-7",
                  "kind": "text",
                  "text": "2019 novel coronavirus",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Early name used in 2020 titles."
                },
                {
                  "id": "covid-text-8",
                  "kind": "text",
                  "text": "Long COVID",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Common name for post-acute COVID-19 syndrome, used as title word and keyword in the examples."
                },
                {
                  "id": "covid-text-9",
                  "kind": "text",
                  "text": "Post-COVID Conditions",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Entry term of Post-Acute COVID-19 Syndrome."
                },
                {
                  "id": "covid-text-10",
                  "kind": "text",
                  "text": "post-COVID-19 condition",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "WHO term for long COVID."
                },
                {
                  "id": "covid-text-11",
                  "kind": "text",
                  "text": "post-acute sequelae of SARS-CoV-2",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "PASC full name used in example 2."
                },
                {
                  "id": "covid-text-12",
                  "kind": "text",
                  "text": "post-acute COVID-19 syndrome",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Heading name used as title words."
                },
                {
                  "id": "covid-text-13",
                  "kind": "text",
                  "text": "long-haul COVID",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Lay variant for long COVID."
                },
                {
                  "id": "covid-text-14",
                  "kind": "text",
                  "text": "post-COVID",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Prefix form used in titles such as post-COVID cognitive impairment."
                },
                {
                  "id": "covid-text-15",
                  "kind": "text",
                  "text": "MIS-C",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Distinctive abbreviation for multisystem inflammatory syndrome in children."
                },
                {
                  "id": "covid-text-16",
                  "kind": "text",
                  "text": "multisystem inflammatory syndrome in children",
                  "fields": [
                    "tw"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Distinctive multi-word name of MIS-C."
                },
                {
                  "id": "covid-text-17",
                  "kind": "text",
                  "text": "paediatric inflammatory multisystem syndrome",
                  "fields": [
                    "tw"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "British name (PIMS-TS) for MIS-C."
                }
              ],
              "required": true
            },
            {
              "key": "neuro",
              "role": "outcome",
              "label": "Neurocognitive and neurological outcomes",
              "terms": [
                {
                  "id": "neuro-mesh-0",
                  "kind": "mesh",
                  "label": "Cognition",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Central cognition heading without noisy narrower headings.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-1",
                  "kind": "mesh",
                  "label": "Cognitive Dysfunction",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Specific heading for cognitive impairment, including post-COVID cognitive deficits.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-2",
                  "kind": "mesh",
                  "label": "Neurocognitive Disorders",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Heading for neurocognitive disorders as a main topic.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-3",
                  "kind": "mesh",
                  "label": "Memory, Episodic",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Memory domain affected after COVID.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-4",
                  "kind": "mesh",
                  "label": "Memory, Short-Term",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Working memory domain often tested.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-5",
                  "kind": "mesh",
                  "label": "Memory Disorders",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Memory impairment outcomes.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-6",
                  "kind": "mesh",
                  "label": "Executive Function",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Cognitive domain named in the model strategy.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-7",
                  "kind": "mesh",
                  "label": "Attention",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Attention domain without unrelated narrower headings.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-8",
                  "kind": "mesh",
                  "label": "Mental Fatigue",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Closest heading for brain fog and cognitive fatigue.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-9",
                  "kind": "mesh",
                  "label": "Neurologic Manifestations",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Neurological symptoms of COVID and long COVID.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-mesh-10",
                  "kind": "mesh",
                  "label": "Neuropsychological Tests",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Records whose main topic is cognitive testing.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "neuro-text-0",
                  "kind": "text",
                  "text": "cognition",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Core outcome word and author keyword in example 1."
                },
                {
                  "id": "neuro-text-1",
                  "kind": "text",
                  "text": "cognitive",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Adjective in titles about cognitive impairment or outcomes."
                },
                {
                  "id": "neuro-text-2",
                  "kind": "text",
                  "text": "neurocognitive",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Outcome term defining the review."
                },
                {
                  "id": "neuro-text-3",
                  "kind": "text",
                  "text": "memory",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Memory outcomes appear in titles and keywords."
                },
                {
                  "id": "neuro-text-4",
                  "kind": "text",
                  "text": "executive function",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Cognitive domain named by authors."
                },
                {
                  "id": "neuro-text-5",
                  "kind": "text",
                  "text": "cognitive impairment",
                  "fields": [
                    "tiab",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Common finding in abstracts and keywords."
                },
                {
                  "id": "neuro-text-6",
                  "kind": "text",
                  "text": "cognitive dysfunction",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Heading name used in abstracts."
                },
                {
                  "id": "neuro-text-7",
                  "kind": "text",
                  "text": "cognitive decline",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Outcome phrasing in abstracts."
                },
                {
                  "id": "neuro-text-8",
                  "kind": "text",
                  "text": "cognitive deficit",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Finding with singular and plural forms."
                },
                {
                  "id": "neuro-text-9",
                  "kind": "text",
                  "text": "cognitive symptom",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Symptom phrasing in long COVID abstracts."
                },
                {
                  "id": "neuro-text-10",
                  "kind": "text",
                  "text": "memory impairment",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Memory finding in abstracts."
                },
                {
                  "id": "neuro-text-11",
                  "kind": "text",
                  "text": "brain fog",
                  "fields": [
                    "tiab",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Lay term for long COVID cognitive symptoms."
                },
                {
                  "id": "neuro-text-12",
                  "kind": "text",
                  "text": "neuropsychological",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Testing and outcome term used by authors."
                },
                {
                  "id": "neuro-text-13",
                  "kind": "text",
                  "text": "neurological symptom",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Neurological outcome phrasing."
                },
                {
                  "id": "neuro-text-14",
                  "kind": "text",
                  "text": "neurologic symptom",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "American spelling variant."
                },
                {
                  "id": "neuro-text-15",
                  "kind": "text",
                  "text": "neurological manifestation",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Phrasing for neurological sequelae."
                },
                {
                  "id": "neuro-text-16",
                  "kind": "text",
                  "text": "neurologic manifestation",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Variant used in the title of example 2."
                },
                {
                  "id": "neuro-text-17",
                  "kind": "text",
                  "text": "neuro-PASC",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Term for neurological long COVID used in example 2."
                },
                {
                  "id": "neuro-text-18",
                  "kind": "text",
                  "text": "neurology",
                  "fields": [
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Author keyword in example 2."
                }
              ],
              "required": true
            },
            {
              "key": "vaccine",
              "role": "exposure",
              "label": "COVID-19 vaccination",
              "terms": [
                {
                  "id": "vaccine-mesh-0",
                  "kind": "mesh",
                  "label": "COVID-19 Vaccines",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Core heading; exploding it includes the specific vaccine headings such as BNT162.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "vaccine-mesh-1",
                  "kind": "mesh",
                  "label": "Vaccination",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Act of vaccination as a main topic.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "vaccine-mesh-2",
                  "kind": "mesh",
                  "label": "Breakthrough Infections",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Infection after vaccination, which shows vaccination status.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "vaccine-scr-0",
                  "kind": "scr",
                  "label": "COVID-19 breakthrough infections",
                  "origin": "ai",
                  "enabled": true,
                  "rationale": "Supplementary Concept for COVID-19 breakthrough infections.",
                  "validation": {
                    "status": "unchecked"
                  }
                },
                {
                  "id": "vaccine-text-0",
                  "kind": "text",
                  "text": "vaccin",
                  "fields": [
                    "ti",
                    "tiab",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Covers vaccine, vaccines, vaccination and vaccinated; example 1 names vaccination only in the abstract."
                },
                {
                  "id": "vaccine-text-1",
                  "kind": "text",
                  "text": "immunization",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Synonym of vaccination."
                },
                {
                  "id": "vaccine-text-2",
                  "kind": "text",
                  "text": "immunisation",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "British spelling."
                },
                {
                  "id": "vaccine-text-3",
                  "kind": "text",
                  "text": "breakthrough infection",
                  "fields": [
                    "ti",
                    "tiab",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Phrasing for infection after vaccination, used in example 2."
                },
                {
                  "id": "vaccine-text-4",
                  "kind": "text",
                  "text": "BNT162b2",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Pfizer-BioNTech vaccine name."
                },
                {
                  "id": "vaccine-text-5",
                  "kind": "text",
                  "text": "mRNA-1273",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Moderna vaccine name."
                },
                {
                  "id": "vaccine-text-6",
                  "kind": "text",
                  "text": "ChAdOx1",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "AstraZeneca vaccine name."
                },
                {
                  "id": "vaccine-text-7",
                  "kind": "text",
                  "text": "Ad26.COV2.S",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Janssen vaccine name."
                }
              ],
              "required": true
            }
          ],
          "limits": {
            "dateTo": null,
            "dateFrom": "2020",
            "languages": [
              "english"
            ],
            "humansOnly": false,
            "excludePublicationTypes": [
              {
                "label": "Comment",
                "validation": {
                  "status": "unchecked"
                }
              },
              {
                "label": "Case Reports",
                "validation": {
                  "status": "unchecked"
                }
              },
              {
                "label": "Editorial",
                "validation": {
                  "status": "unchecked"
                }
              },
              {
                "label": "Preprint",
                "validation": {
                  "status": "unchecked"
                }
              }
            ]
          },
          "schema": "picoportal.search-strategy/1",
          "question": "What is the association between COVID-19 vaccination and neurocognitive outcomes of COVID-19, including long COVID and multisystem inflammatory syndrome in children?",
          "objective": "To identify studies examining whether COVID-19 vaccination is associated with neurocognitive and neurological outcomes of COVID-19, including long COVID (post-acute sequelae) and multisystem inflammatory syndrome in children (MIS-C)."
        }
      }
    },
    {
      "seq": 5,
      "event": {
        "type": "stage",
        "stage": "validating_vocabulary",
        "message": "Checking every MeSH heading, Supplementary Concept and publication type against NLM"
      }
    },
    {
      "seq": 6,
      "event": {
        "type": "strategy",
        "strategy": {
          "notes": [
            "The searcher's publication-type exclusions (Comment, Case Reports, Editorial, Preprint) are final, so excludePublicationTypes is empty.",
            "Following the model strategy, the outcome block is required because the review is defined by neurocognitive outcomes.",
            "Vaccine-specific headings (BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, ChAdOx1 nCoV-19, Ad26COVS1) are not listed separately because they fall under the exploded COVID-19 Vaccines heading.",
            "vaccin* in tiab is broad, but ANDing with the COVID and neuro blocks keeps the result small; it is needed because example 1 mentions vaccination only in its abstract.",
            "Broad neurology headings (Nervous System Diseases, Headache) and mental-health terms were left out to keep the outcome block focused on neurocognition; add them if the searcher wants to include broader neurological sequelae.",
            "The abbreviation PASC alone was left out because it is ambiguous; the spelled-out form and neuro-PASC are included."
          ],
          "blocks": [
            {
              "key": "covid",
              "role": "condition",
              "label": "COVID-19, long COVID and MIS-C",
              "terms": [
                {
                  "id": "covid-mesh-0",
                  "kind": "mesh",
                  "label": "COVID-19",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Core heading for the disease that must be a main topic.",
                  "validation": {
                    "ui": "D000086382",
                    "label": "COVID-19",
                    "status": "valid"
                  }
                },
                {
                  "id": "covid-mesh-1",
                  "kind": "mesh",
                  "label": "Post-Acute COVID-19 Syndrome",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Heading for long COVID, a named part of the question.",
                  "validation": {
                    "ui": "D000094024",
                    "label": "Post-Acute COVID-19 Syndrome",
                    "status": "valid"
                  }
                },
                {
                  "id": "covid-mesh-2",
                  "kind": "mesh",
                  "label": "SARS-CoV-2",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Virus heading catches records indexed on the infecting agent.",
                  "validation": {
                    "ui": "D000086402",
                    "label": "SARS-CoV-2",
                    "status": "valid"
                  }
                },
                {
                  "id": "covid-scr-0",
                  "kind": "scr",
                  "label": "pediatric multisystem inflammatory disease, COVID-19 related",
                  "origin": "ai",
                  "enabled": true,
                  "rationale": "Supplementary Concept for MIS-C, a named part of the question.",
                  "validation": {
                    "ui": "C000705967",
                    "label": "pediatric multisystem inflammatory disease, COVID-19 related",
                    "status": "valid"
                  }
                },
                {
                  "id": "covid-text-0",
                  "kind": "text",
                  "text": "COVID-19",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Main disease name in titles."
                },
                {
                  "id": "covid-text-1",
                  "kind": "text",
                  "text": "COVID19",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Unhyphenated spelling variant."
                },
                {
                  "id": "covid-text-2",
                  "kind": "text",
                  "text": "COVID 19",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Spaced spelling variant."
                },
                {
                  "id": "covid-text-3",
                  "kind": "text",
                  "text": "SARS-CoV-2",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Virus name used in titles about infection."
                },
                {
                  "id": "covid-text-4",
                  "kind": "text",
                  "text": "SARS CoV 2",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Unhyphenated variant of the virus name."
                },
                {
                  "id": "covid-text-5",
                  "kind": "text",
                  "text": "SARS-CoV-2 Infection",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Entry term of COVID-19."
                },
                {
                  "id": "covid-text-6",
                  "kind": "text",
                  "text": "Coronavirus Disease 2019",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Full entry term of COVID-19."
                },
                {
                  "id": "covid-text-7",
                  "kind": "text",
                  "text": "2019 novel coronavirus",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Early name used in 2020 titles."
                },
                {
                  "id": "covid-text-8",
                  "kind": "text",
                  "text": "Long COVID",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Common name for post-acute COVID-19 syndrome, used as title word and keyword in the examples."
                },
                {
                  "id": "covid-text-9",
                  "kind": "text",
                  "text": "Post-COVID Conditions",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Entry term of Post-Acute COVID-19 Syndrome."
                },
                {
                  "id": "covid-text-10",
                  "kind": "text",
                  "text": "post-COVID-19 condition",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "WHO term for long COVID."
                },
                {
                  "id": "covid-text-11",
                  "kind": "text",
                  "text": "post-acute sequelae of SARS-CoV-2",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "PASC full name used in example 2."
                },
                {
                  "id": "covid-text-12",
                  "kind": "text",
                  "text": "post-acute COVID-19 syndrome",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Heading name used as title words."
                },
                {
                  "id": "covid-text-13",
                  "kind": "text",
                  "text": "long-haul COVID",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Lay variant for long COVID."
                },
                {
                  "id": "covid-text-14",
                  "kind": "text",
                  "text": "post-COVID",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Prefix form used in titles such as post-COVID cognitive impairment."
                },
                {
                  "id": "covid-text-15",
                  "kind": "text",
                  "text": "MIS-C",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Distinctive abbreviation for multisystem inflammatory syndrome in children."
                },
                {
                  "id": "covid-text-16",
                  "kind": "text",
                  "text": "multisystem inflammatory syndrome in children",
                  "fields": [
                    "tw"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Distinctive multi-word name of MIS-C."
                },
                {
                  "id": "covid-text-17",
                  "kind": "text",
                  "text": "paediatric inflammatory multisystem syndrome",
                  "fields": [
                    "tw"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "British name (PIMS-TS) for MIS-C."
                },
                {
                  "id": "covid-mesh-0-et2",
                  "kind": "text",
                  "text": "2019-nCoV Disease",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086382"
                },
                {
                  "id": "covid-mesh-0-et3",
                  "kind": "text",
                  "text": "COVID-19 Pandemic",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086382"
                },
                {
                  "id": "covid-mesh-0-et4",
                  "kind": "text",
                  "text": "COVID-19 Pandemics",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086382"
                },
                {
                  "id": "covid-mesh-0-et5",
                  "kind": "text",
                  "text": "2019-nCoV Infection",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086382"
                },
                {
                  "id": "covid-mesh-0-et7",
                  "kind": "text",
                  "text": "Coronavirus Disease-19",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086382"
                },
                {
                  "id": "covid-mesh-0-et8",
                  "kind": "text",
                  "text": "COVID-19 Virus Disease",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086382"
                },
                {
                  "id": "covid-mesh-1-et3",
                  "kind": "text",
                  "text": "Long Haul COVID-19",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000094024"
                },
                {
                  "id": "covid-mesh-1-et5",
                  "kind": "text",
                  "text": "Post COVID-19 Syndrome",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000094024"
                },
                {
                  "id": "covid-mesh-1-et6",
                  "kind": "text",
                  "text": "Post-COVID-19 Syndrome",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000094024"
                },
                {
                  "id": "covid-mesh-1-et7",
                  "kind": "text",
                  "text": "Post Acute COVID-19 Syndrome",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000094024"
                },
                {
                  "id": "covid-mesh-1-et8",
                  "kind": "text",
                  "text": "Post-Acute COVID-19 Sequelae",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000094024"
                },
                {
                  "id": "covid-mesh-1-et9",
                  "kind": "text",
                  "text": "Post-Acute Sequelae of COVID-19",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000094024"
                },
                {
                  "id": "covid-mesh-2-et1",
                  "kind": "text",
                  "text": "2019-nCoV",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086402"
                },
                {
                  "id": "covid-mesh-2-et2",
                  "kind": "text",
                  "text": "COVID19 Virus",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086402"
                },
                {
                  "id": "covid-mesh-2-et3",
                  "kind": "text",
                  "text": "COVID-19 Virus",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086402"
                },
                {
                  "id": "covid-mesh-2-et4",
                  "kind": "text",
                  "text": "SARS-CoV-2 Virus",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086402"
                },
                {
                  "id": "covid-mesh-2-et5",
                  "kind": "text",
                  "text": "Wuhan Coronavirus",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086402"
                },
                {
                  "id": "covid-mesh-2-et6",
                  "kind": "text",
                  "text": "SARS Coronavirus 2",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086402"
                }
              ],
              "required": true
            },
            {
              "key": "neuro",
              "role": "outcome",
              "label": "Neurocognitive and neurological outcomes",
              "terms": [
                {
                  "id": "neuro-mesh-0",
                  "kind": "mesh",
                  "label": "Cognition",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Central cognition heading without noisy narrower headings.",
                  "validation": {
                    "ui": "D003071",
                    "label": "Cognition",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-1",
                  "kind": "mesh",
                  "label": "Cognitive Dysfunction",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Specific heading for cognitive impairment, including post-COVID cognitive deficits.",
                  "validation": {
                    "ui": "D060825",
                    "label": "Cognitive Dysfunction",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-2",
                  "kind": "mesh",
                  "label": "Neurocognitive Disorders",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Heading for neurocognitive disorders as a main topic.",
                  "validation": {
                    "ui": "D019965",
                    "label": "Neurocognitive Disorders",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-3",
                  "kind": "mesh",
                  "label": "Memory, Episodic",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Memory domain affected after COVID.",
                  "validation": {
                    "ui": "D061212",
                    "label": "Memory, Episodic",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-4",
                  "kind": "mesh",
                  "label": "Memory, Short-Term",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Working memory domain often tested.",
                  "validation": {
                    "ui": "D008570",
                    "label": "Memory, Short-Term",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-5",
                  "kind": "mesh",
                  "label": "Memory Disorders",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Memory impairment outcomes.",
                  "validation": {
                    "ui": "D008569",
                    "label": "Memory Disorders",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-6",
                  "kind": "mesh",
                  "label": "Executive Function",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Cognitive domain named in the model strategy.",
                  "validation": {
                    "ui": "D056344",
                    "label": "Executive Function",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-7",
                  "kind": "mesh",
                  "label": "Attention",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Attention domain without unrelated narrower headings.",
                  "validation": {
                    "ui": "D001288",
                    "label": "Attention",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-8",
                  "kind": "mesh",
                  "label": "Mental Fatigue",
                  "major": false,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Closest heading for brain fog and cognitive fatigue.",
                  "validation": {
                    "ui": "D005222",
                    "label": "Mental Fatigue",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-9",
                  "kind": "mesh",
                  "label": "Neurologic Manifestations",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Neurological symptoms of COVID and long COVID.",
                  "validation": {
                    "ui": "D009461",
                    "label": "Neurologic Manifestations",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-mesh-10",
                  "kind": "mesh",
                  "label": "Neuropsychological Tests",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": false,
                  "rationale": "Records whose main topic is cognitive testing.",
                  "validation": {
                    "ui": "D009483",
                    "label": "Neuropsychological Tests",
                    "status": "valid"
                  }
                },
                {
                  "id": "neuro-text-0",
                  "kind": "text",
                  "text": "cognition",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Core outcome word and author keyword in example 1."
                },
                {
                  "id": "neuro-text-1",
                  "kind": "text",
                  "text": "cognitive",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Adjective in titles about cognitive impairment or outcomes."
                },
                {
                  "id": "neuro-text-2",
                  "kind": "text",
                  "text": "neurocognitive",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Outcome term defining the review."
                },
                {
                  "id": "neuro-text-3",
                  "kind": "text",
                  "text": "memory",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Memory outcomes appear in titles and keywords."
                },
                {
                  "id": "neuro-text-4",
                  "kind": "text",
                  "text": "executive function",
                  "fields": [
                    "ti",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Cognitive domain named by authors."
                },
                {
                  "id": "neuro-text-5",
                  "kind": "text",
                  "text": "cognitive impairment",
                  "fields": [
                    "tiab",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Common finding in abstracts and keywords."
                },
                {
                  "id": "neuro-text-6",
                  "kind": "text",
                  "text": "cognitive dysfunction",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Heading name used in abstracts."
                },
                {
                  "id": "neuro-text-7",
                  "kind": "text",
                  "text": "cognitive decline",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Outcome phrasing in abstracts."
                },
                {
                  "id": "neuro-text-8",
                  "kind": "text",
                  "text": "cognitive deficit",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Finding with singular and plural forms."
                },
                {
                  "id": "neuro-text-9",
                  "kind": "text",
                  "text": "cognitive symptom",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Symptom phrasing in long COVID abstracts."
                },
                {
                  "id": "neuro-text-10",
                  "kind": "text",
                  "text": "memory impairment",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Memory finding in abstracts."
                },
                {
                  "id": "neuro-text-11",
                  "kind": "text",
                  "text": "brain fog",
                  "fields": [
                    "tiab",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Lay term for long COVID cognitive symptoms."
                },
                {
                  "id": "neuro-text-12",
                  "kind": "text",
                  "text": "neuropsychological",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Testing and outcome term used by authors."
                },
                {
                  "id": "neuro-text-13",
                  "kind": "text",
                  "text": "neurological symptom",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Neurological outcome phrasing."
                },
                {
                  "id": "neuro-text-14",
                  "kind": "text",
                  "text": "neurologic symptom",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "American spelling variant."
                },
                {
                  "id": "neuro-text-15",
                  "kind": "text",
                  "text": "neurological manifestation",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Phrasing for neurological sequelae."
                },
                {
                  "id": "neuro-text-16",
                  "kind": "text",
                  "text": "neurologic manifestation",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Variant used in the title of example 2."
                },
                {
                  "id": "neuro-text-17",
                  "kind": "text",
                  "text": "neuro-PASC",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Term for neurological long COVID used in example 2."
                },
                {
                  "id": "neuro-text-18",
                  "kind": "text",
                  "text": "neurology",
                  "fields": [
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Author keyword in example 2."
                },
                {
                  "id": "neuro-mesh-0-et1",
                  "kind": "text",
                  "text": "Insight",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D003071"
                },
                {
                  "id": "neuro-mesh-0-et2",
                  "kind": "text",
                  "text": "Cognitive Function",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D003071"
                },
                {
                  "id": "neuro-mesh-1-et2",
                  "kind": "text",
                  "text": "Cognitive Disorder",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D060825"
                },
                {
                  "id": "neuro-mesh-1-et3",
                  "kind": "text",
                  "text": "Mental Deterioration",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D060825"
                },
                {
                  "id": "neuro-mesh-1-et4",
                  "kind": "text",
                  "text": "Cognitive Impairments",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D060825"
                },
                {
                  "id": "neuro-mesh-1-et5",
                  "kind": "text",
                  "text": "Mild Cognitive Impairment",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D060825"
                },
                {
                  "id": "neuro-mesh-2-et1",
                  "kind": "text",
                  "text": "Kandinsky Syndrome",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D019965"
                },
                {
                  "id": "neuro-mesh-2-et2",
                  "kind": "text",
                  "text": "Clerambault Syndrome",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D019965"
                },
                {
                  "id": "neuro-mesh-2-et3",
                  "kind": "text",
                  "text": "Organic Mental Disorders",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D019965"
                },
                {
                  "id": "neuro-mesh-2-et4",
                  "kind": "text",
                  "text": "Mild Neurocognitive Disorder",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D019965"
                },
                {
                  "id": "neuro-mesh-2-et5",
                  "kind": "text",
                  "text": "Nonpsychotic Organic Brain Syndrome",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D019965"
                },
                {
                  "id": "neuro-mesh-3-et1",
                  "kind": "text",
                  "text": "Episodic Memory",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D061212"
                },
                {
                  "id": "neuro-mesh-3-et2",
                  "kind": "text",
                  "text": "Prospective Memory",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D061212"
                },
                {
                  "id": "neuro-mesh-3-et3",
                  "kind": "text",
                  "text": "Autobiographical Memory",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D061212"
                },
                {
                  "id": "neuro-mesh-4-et1",
                  "kind": "text",
                  "text": "Working Memory",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D008570"
                },
                {
                  "id": "neuro-mesh-4-et2",
                  "kind": "text",
                  "text": "Immediate Recall",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D008570"
                },
                {
                  "id": "neuro-mesh-5-et1",
                  "kind": "text",
                  "text": "Memory Loss",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D008569"
                },
                {
                  "id": "neuro-mesh-5-et2",
                  "kind": "text",
                  "text": "Memory Deficits",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D008569"
                },
                {
                  "id": "neuro-mesh-5-et3",
                  "kind": "text",
                  "text": "Spatial Memory Disorder",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D008569"
                },
                {
                  "id": "neuro-mesh-5-et4",
                  "kind": "text",
                  "text": "Semantic Memory Disorder",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D008569"
                },
                {
                  "id": "neuro-mesh-5-et5",
                  "kind": "text",
                  "text": "Age-Related Memory Disorders",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D008569"
                },
                {
                  "id": "neuro-mesh-6-et1",
                  "kind": "text",
                  "text": "Executive Control",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D056344"
                },
                {
                  "id": "neuro-mesh-7-et1",
                  "kind": "text",
                  "text": "Social Attention",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D001288"
                },
                {
                  "id": "neuro-mesh-7-et2",
                  "kind": "text",
                  "text": "Focus of Attention",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D001288"
                },
                {
                  "id": "neuro-mesh-7-et3",
                  "kind": "text",
                  "text": "Selective Attention",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D001288"
                },
                {
                  "id": "neuro-mesh-7-et4",
                  "kind": "text",
                  "text": "Mental Concentration",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D001288"
                },
                {
                  "id": "neuro-mesh-8-et2",
                  "kind": "text",
                  "text": "Mental Fog",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D005222"
                },
                {
                  "id": "neuro-mesh-8-et3",
                  "kind": "text",
                  "text": "Cognitive Weariness",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D005222"
                },
                {
                  "id": "neuro-mesh-8-et4",
                  "kind": "text",
                  "text": "Cognitive Exhaustion",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D005222"
                },
                {
                  "id": "neuro-mesh-9-et1",
                  "kind": "text",
                  "text": "Neurologic Signs",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009461"
                },
                {
                  "id": "neuro-mesh-9-et2",
                  "kind": "text",
                  "text": "Neurologic Deficits",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009461"
                },
                {
                  "id": "neuro-mesh-9-et3",
                  "kind": "text",
                  "text": "Neurologic Findings",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009461"
                },
                {
                  "id": "neuro-mesh-9-et4",
                  "kind": "text",
                  "text": "Neurologic Symptoms",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009461"
                },
                {
                  "id": "neuro-mesh-9-et5",
                  "kind": "text",
                  "text": "Neurologic Dysfunction",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009461"
                },
                {
                  "id": "neuro-mesh-9-et7",
                  "kind": "text",
                  "text": "Focal Neurologic Deficits",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009461"
                },
                {
                  "id": "neuro-mesh-10-et1",
                  "kind": "text",
                  "text": "NEPSY",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009483"
                },
                {
                  "id": "neuro-mesh-10-et2",
                  "kind": "text",
                  "text": "AX-CPT",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009483"
                },
                {
                  "id": "neuro-mesh-10-et3",
                  "kind": "text",
                  "text": "CANTAB",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009483"
                },
                {
                  "id": "neuro-mesh-10-et4",
                  "kind": "text",
                  "text": "Clock Test",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009483"
                },
                {
                  "id": "neuro-mesh-10-et5",
                  "kind": "text",
                  "text": "Aphasia Tests",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009483"
                },
                {
                  "id": "neuro-mesh-10-et6",
                  "kind": "text",
                  "text": "Cognitive Test",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D009483"
                }
              ],
              "required": true
            },
            {
              "key": "vaccine",
              "role": "exposure",
              "label": "COVID-19 vaccination",
              "terms": [
                {
                  "id": "vaccine-mesh-0",
                  "kind": "mesh",
                  "label": "COVID-19 Vaccines",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Core heading; exploding it includes the specific vaccine headings such as BNT162.",
                  "validation": {
                    "ui": "D000086663",
                    "label": "COVID-19 Vaccines",
                    "status": "valid"
                  }
                },
                {
                  "id": "vaccine-mesh-1",
                  "kind": "mesh",
                  "label": "Vaccination",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Act of vaccination as a main topic.",
                  "validation": {
                    "ui": "D014611",
                    "label": "Vaccination",
                    "status": "valid"
                  }
                },
                {
                  "id": "vaccine-mesh-2",
                  "kind": "mesh",
                  "label": "Breakthrough Infections",
                  "major": true,
                  "origin": "ai",
                  "enabled": true,
                  "explode": true,
                  "rationale": "Infection after vaccination, which shows vaccination status.",
                  "validation": {
                    "ui": "D000093742",
                    "label": "Breakthrough Infections",
                    "status": "valid"
                  }
                },
                {
                  "id": "vaccine-scr-0",
                  "kind": "scr",
                  "label": "COVID-19 breakthrough infections",
                  "origin": "ai",
                  "enabled": true,
                  "rationale": "Supplementary Concept for COVID-19 breakthrough infections.",
                  "validation": {
                    "ui": "C000718127",
                    "label": "COVID-19 breakthrough infections",
                    "status": "valid"
                  }
                },
                {
                  "id": "vaccine-text-0",
                  "kind": "text",
                  "text": "vaccin",
                  "fields": [
                    "ti",
                    "tiab",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Covers vaccine, vaccines, vaccination and vaccinated; example 1 names vaccination only in the abstract."
                },
                {
                  "id": "vaccine-text-1",
                  "kind": "text",
                  "text": "immunization",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Synonym of vaccination."
                },
                {
                  "id": "vaccine-text-2",
                  "kind": "text",
                  "text": "immunisation",
                  "fields": [
                    "ti"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "British spelling."
                },
                {
                  "id": "vaccine-text-3",
                  "kind": "text",
                  "text": "breakthrough infection",
                  "fields": [
                    "ti",
                    "tiab",
                    "ot"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": true,
                  "proximity": null,
                  "rationale": "Phrasing for infection after vaccination, used in example 2."
                },
                {
                  "id": "vaccine-text-4",
                  "kind": "text",
                  "text": "BNT162b2",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Pfizer-BioNTech vaccine name."
                },
                {
                  "id": "vaccine-text-5",
                  "kind": "text",
                  "text": "mRNA-1273",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Moderna vaccine name."
                },
                {
                  "id": "vaccine-text-6",
                  "kind": "text",
                  "text": "ChAdOx1",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "AstraZeneca vaccine name."
                },
                {
                  "id": "vaccine-text-7",
                  "kind": "text",
                  "text": "Ad26.COV2.S",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "ai",
                  "enabled": true,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "Janssen vaccine name."
                },
                {
                  "id": "vaccine-mesh-0-et1",
                  "kind": "text",
                  "text": "SARS2 Vaccine",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086663"
                },
                {
                  "id": "vaccine-mesh-0-et2",
                  "kind": "text",
                  "text": "SARS2 Vaccines",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086663"
                },
                {
                  "id": "vaccine-mesh-0-et3",
                  "kind": "text",
                  "text": "COVID19 Vaccine",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086663"
                },
                {
                  "id": "vaccine-mesh-0-et4",
                  "kind": "text",
                  "text": "COVID 19 Vaccine",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086663"
                },
                {
                  "id": "vaccine-mesh-0-et5",
                  "kind": "text",
                  "text": "COVID-19 Vaccine",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086663"
                },
                {
                  "id": "vaccine-mesh-0-et6",
                  "kind": "text",
                  "text": "COVID19 Vaccines",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000086663"
                },
                {
                  "id": "vaccine-mesh-2-et1",
                  "kind": "text",
                  "text": "Treatment Emergent Infections",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000093742"
                },
                {
                  "id": "vaccine-mesh-2-et2",
                  "kind": "text",
                  "text": "Vaccine Breakthrough Infections",
                  "fields": [
                    "tiab"
                  ],
                  "origin": "mesh_entry_term",
                  "enabled": false,
                  "truncate": false,
                  "proximity": null,
                  "rationale": "MeSH entry term of D000093742"
                }
              ],
              "required": true
            }
          ],
          "limits": {
            "dateTo": null,
            "dateFrom": "2020",
            "languages": [
              "english"
            ],
            "humansOnly": false,
            "excludePublicationTypes": [
              {
                "label": "Comment",
                "validation": {
                  "ui": "D016420",
                  "label": "Comment",
                  "status": "valid"
                }
              },
              {
                "label": "Case Reports",
                "validation": {
                  "ui": "D002363",
                  "label": "Case Reports",
                  "status": "valid"
                }
              },
              {
                "label": "Editorial",
                "validation": {
                  "ui": "D016421",
                  "label": "Editorial",
                  "status": "valid"
                }
              },
              {
                "label": "Preprint",
                "validation": {
                  "ui": "D000076942",
                  "label": "Preprint",
                  "status": "valid"
                }
              }
            ]
          },
          "schema": "picoportal.search-strategy/1",
          "question": "What is the association between COVID-19 vaccination and neurocognitive outcomes of COVID-19, including long COVID and multisystem inflammatory syndrome in children?",
          "objective": "To identify studies examining whether COVID-19 vaccination is associated with neurocognitive and neurological outcomes of COVID-19, including long COVID (post-acute sequelae) and multisystem inflammatory syndrome in children (MIS-C)."
        }
      }
    },
    {
      "seq": 7,
      "event": {
        "type": "stage",
        "stage": "counting",
        "message": "Running 20 lines on PubMed"
      }
    },
    {
      "seq": 8,
      "event": {
        "done": 1,
        "type": "progress",
        "total": 20,
        "message": "Line 1: 268,269 records"
      }
    },
    {
      "seq": 9,
      "event": {
        "done": 2,
        "type": "progress",
        "total": 20,
        "message": "Line 2: 387,506 records"
      }
    },
    {
      "seq": 10,
      "event": {
        "done": 3,
        "type": "progress",
        "total": 20,
        "message": "Line 3: 2,453 records"
      }
    },
    {
      "seq": 11,
      "event": {
        "done": 4,
        "type": "progress",
        "total": 20,
        "message": "Line 5: 5,477 records"
      }
    },
    {
      "seq": 12,
      "event": {
        "done": 5,
        "type": "progress",
        "total": 20,
        "message": "Line 6: 440,033 records"
      }
    },
    {
      "seq": 13,
      "event": {
        "done": 6,
        "type": "progress",
        "total": 20,
        "message": "Line 7: 281,973 records"
      }
    },
    {
      "seq": 14,
      "event": {
        "done": 7,
        "type": "progress",
        "total": 20,
        "message": "Line 8: 320,765 records"
      }
    },
    {
      "seq": 15,
      "event": {
        "done": 8,
        "type": "progress",
        "total": 20,
        "message": "Line 9: 324,011 records"
      }
    },
    {
      "seq": 16,
      "event": {
        "done": 9,
        "type": "progress",
        "total": 20,
        "message": "Line 12: 74,035 records"
      }
    },
    {
      "seq": 17,
      "event": {
        "done": 10,
        "type": "progress",
        "total": 20,
        "message": "Line 10: 151,788 records"
      }
    },
    {
      "seq": 18,
      "event": {
        "done": 11,
        "type": "progress",
        "total": 20,
        "message": "Line 11: 682,882 records"
      }
    },
    {
      "seq": 19,
      "event": {
        "done": 12,
        "type": "progress",
        "total": 20,
        "message": "Line 13: 294,470 records"
      }
    },
    {
      "seq": 20,
      "event": {
        "done": 13,
        "type": "progress",
        "total": 20,
        "message": "Line 4: 2,403 records"
      }
    },
    {
      "seq": 21,
      "event": {
        "done": 14,
        "type": "progress",
        "total": 20,
        "message": "Line 14: 510,697 records"
      }
    },
    {
      "seq": 22,
      "event": {
        "done": 15,
        "type": "progress",
        "total": 20,
        "message": "Line 15: 130,196 records"
      }
    },
    {
      "seq": 23,
      "event": {
        "done": 16,
        "type": "progress",
        "total": 20,
        "message": "Line 16: 532,214 records"
      }
    },
    {
      "seq": 24,
      "event": {
        "done": 17,
        "type": "progress",
        "total": 20,
        "message": "Line 17: 1,237 records"
      }
    },
    {
      "seq": 25,
      "event": {
        "done": 18,
        "type": "progress",
        "total": 20,
        "message": "Line 18: 4,270,113 records"
      }
    },
    {
      "seq": 26,
      "event": {
        "done": 19,
        "type": "progress",
        "total": 20,
        "message": "Line 19: 1,078 records"
      }
    },
    {
      "seq": 27,
      "event": {
        "done": 20,
        "type": "progress",
        "total": 20,
        "message": "Line 20: 1,072 records"
      }
    },
    {
      "seq": 28,
      "event": {
        "type": "lines",
        "lines": [
          {
            "no": 1,
            "kind": "terms",
            "refs": [],
            "count": 268269,
            "query": "\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]",
            "issues": [],
            "display": "\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]",
            "termIds": [
              "covid-mesh-0",
              "covid-mesh-1",
              "covid-mesh-2",
              "covid-scr-0"
            ],
            "blockKey": "covid",
            "countedAt": "2026-10-28T12:23:20.613Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"COVID-19\"[MeSH Major Topic] OR \"Post-Acute COVID-19 Syndrome\"[MeSH Major Topic] OR \"SARS-CoV-2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 2,
            "kind": "terms",
            "refs": [],
            "count": 387506,
            "query": "\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]",
            "issues": [],
            "display": "\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]",
            "termIds": [
              "covid-text-0",
              "covid-text-1",
              "covid-text-2",
              "covid-text-3",
              "covid-text-4",
              "covid-text-5",
              "covid-text-6",
              "covid-text-7",
              "covid-text-8",
              "covid-text-9",
              "covid-text-10",
              "covid-text-11",
              "covid-text-12",
              "covid-text-13",
              "covid-text-14"
            ],
            "blockKey": "covid",
            "countedAt": "2026-10-28T12:23:20.882Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post-acute COVID-19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 3,
            "kind": "terms",
            "refs": [],
            "count": 2453,
            "query": "\"MIS-C\"[tiab]",
            "issues": [],
            "display": "\"MIS-C\"[tiab]",
            "termIds": [
              "covid-text-15"
            ],
            "blockKey": "covid",
            "countedAt": "2026-10-28T12:23:21.410Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"MIS-C\"[Title/Abstract]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 4,
            "kind": "terms",
            "refs": [],
            "count": 2403,
            "query": "\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]",
            "issues": [],
            "display": "\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]",
            "termIds": [
              "covid-text-16",
              "covid-text-17"
            ],
            "blockKey": "covid",
            "countedAt": "2026-10-28T12:23:24.625Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 5,
            "kind": "terms",
            "refs": [],
            "count": 5477,
            "query": "\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot]",
            "issues": [],
            "display": "\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot]",
            "termIds": [
              "covid-text-8",
              "covid-text-11"
            ],
            "blockKey": "covid",
            "countedAt": "2026-10-28T12:23:21.917Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 6,
            "kind": "block",
            "refs": [
              1,
              2,
              3,
              4,
              5
            ],
            "count": 440033,
            "query": "(\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])",
            "issues": [],
            "display": "1 OR 2 OR 3 OR 4 OR 5",
            "blockKey": "covid",
            "countedAt": "2026-10-28T12:23:22.273Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR \"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title] OR \"MIS-C\"[Title/Abstract] OR \"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word] OR \"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 7,
            "kind": "terms",
            "refs": [],
            "count": 281973,
            "query": "\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]",
            "issues": [],
            "display": "\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]",
            "termIds": [
              "neuro-mesh-0",
              "neuro-mesh-1",
              "neuro-mesh-2",
              "neuro-mesh-3",
              "neuro-mesh-4",
              "neuro-mesh-5",
              "neuro-mesh-6",
              "neuro-mesh-7",
              "neuro-mesh-8",
              "neuro-mesh-9",
              "neuro-mesh-10"
            ],
            "blockKey": "neuro",
            "countedAt": "2026-10-28T12:23:22.600Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 8,
            "kind": "terms",
            "refs": [],
            "count": 320765,
            "query": "cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]",
            "issues": [],
            "display": "cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]",
            "termIds": [
              "neuro-text-0",
              "neuro-text-1",
              "neuro-text-3",
              "neuro-text-4"
            ],
            "blockKey": "neuro",
            "countedAt": "2026-10-28T12:23:22.949Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"executive function\"[Title]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 9,
            "kind": "terms",
            "refs": [],
            "count": 324011,
            "query": "neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]",
            "issues": [],
            "display": "neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]",
            "termIds": [
              "neuro-text-2",
              "neuro-text-5",
              "neuro-text-6",
              "neuro-text-7",
              "neuro-text-8",
              "neuro-text-9",
              "neuro-text-10",
              "neuro-text-11",
              "neuro-text-12",
              "neuro-text-13",
              "neuro-text-14",
              "neuro-text-15",
              "neuro-text-16",
              "neuro-text-17"
            ],
            "blockKey": "neuro",
            "countedAt": "2026-10-28T12:23:23.281Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"cognitive dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 10,
            "kind": "terms",
            "refs": [],
            "count": 151788,
            "query": "cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot]",
            "issues": [],
            "display": "cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot]",
            "termIds": [
              "neuro-text-0",
              "neuro-text-3",
              "neuro-text-4",
              "neuro-text-5",
              "neuro-text-11",
              "neuro-text-18"
            ],
            "blockKey": "neuro",
            "countedAt": "2026-10-28T12:23:23.683Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"cognition\"[Other Term] OR \"memory\"[Other Term] OR \"executive function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 11,
            "kind": "block",
            "refs": [
              7,
              8,
              9,
              10
            ],
            "count": 682882,
            "query": "(\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])",
            "issues": [],
            "display": "7 OR 8 OR 9 OR 10",
            "blockKey": "neuro",
            "countedAt": "2026-10-28T12:23:23.991Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR \"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title] OR \"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract] OR \"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 12,
            "kind": "terms",
            "refs": [],
            "count": 74035,
            "query": "\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]",
            "issues": [],
            "display": "\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]",
            "termIds": [
              "vaccine-mesh-0",
              "vaccine-mesh-1",
              "vaccine-mesh-2",
              "vaccine-scr-0"
            ],
            "blockKey": "vaccine",
            "countedAt": "2026-10-28T03:24:35.704Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 13,
            "kind": "terms",
            "refs": [],
            "count": 294470,
            "query": "vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]",
            "issues": [],
            "display": "vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]",
            "termIds": [
              "vaccine-text-0",
              "vaccine-text-1",
              "vaccine-text-2",
              "vaccine-text-3"
            ],
            "blockKey": "vaccine",
            "countedAt": "2026-10-28T12:23:24.285Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 14,
            "kind": "terms",
            "refs": [],
            "count": 510697,
            "query": "vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]",
            "issues": [],
            "display": "vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]",
            "termIds": [
              "vaccine-text-0",
              "vaccine-text-3",
              "vaccine-text-4",
              "vaccine-text-5",
              "vaccine-text-6",
              "vaccine-text-7"
            ],
            "blockKey": "vaccine",
            "countedAt": "2026-10-28T12:23:24.980Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 15,
            "kind": "terms",
            "refs": [],
            "count": 130196,
            "query": "vaccin*[ot] OR \"breakthrough infection*\"[ot]",
            "issues": [],
            "display": "vaccin*[ot] OR \"breakthrough infection*\"[ot]",
            "termIds": [
              "vaccine-text-0",
              "vaccine-text-3"
            ],
            "blockKey": "vaccine",
            "countedAt": "2026-10-28T12:23:25.291Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 16,
            "kind": "block",
            "refs": [
              12,
              13,
              14,
              15
            ],
            "count": 532214,
            "query": "(\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot])",
            "issues": [],
            "display": "12 OR 13 OR 14 OR 15",
            "blockKey": "vaccine",
            "countedAt": "2026-10-28T12:23:25.712Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR \"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title] OR \"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract] OR \"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 17,
            "kind": "combine",
            "refs": [
              6,
              11,
              16
            ],
            "count": 1237,
            "query": "((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))",
            "issues": [],
            "display": "6 AND 11 AND 16",
            "countedAt": "2026-10-28T12:23:26.083Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "(\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR (\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]) OR \"MIS-C\"[Title/Abstract] OR (\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]) OR (\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term])) AND (\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR (\"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title]) OR (\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]) OR (\"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term])) AND (\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR (\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]) OR (\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]) OR (\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]))",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 18,
            "kind": "exclude",
            "refs": [],
            "count": 4270113,
            "query": "\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type]",
            "issues": [],
            "display": "\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type]",
            "countedAt": "2026-10-28T12:23:26.335Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type]",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 19,
            "kind": "not",
            "refs": [
              17,
              18
            ],
            "count": 1078,
            "query": "(((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])",
            "issues": [],
            "display": "17 NOT 18",
            "countedAt": "2026-10-28T12:23:26.837Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "((\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR (\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]) OR \"MIS-C\"[Title/Abstract] OR (\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]) OR (\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term])) AND (\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR (\"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title]) OR (\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]) OR (\"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term])) AND (\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR (\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]) OR (\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]) OR (\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])",
              "quotedPhrasesNotFound": []
            }
          },
          {
            "no": 20,
            "kind": "limits",
            "refs": [
              19
            ],
            "count": 1072,
            "query": "((((\"COVID-19\"[Majr] OR \"Post-Acute COVID-19 Syndrome\"[Majr] OR \"SARS-CoV-2\"[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID-19\"[ti] OR COVID19[ti] OR \"COVID 19\"[ti] OR \"SARS-CoV-2\"[ti] OR \"SARS CoV 2\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"2019 novel coronavirus\"[ti] OR \"Long COVID\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"post-COVID-19 condition\"[ti] OR \"post-acute sequelae of SARS-CoV-2\"[ti] OR \"post-acute COVID-19 syndrome\"[ti] OR \"long-haul COVID\"[ti] OR \"post-COVID\"[ti]) OR (\"MIS-C\"[tiab]) OR (\"multisystem inflammatory syndrome in children\"[tw] OR \"paediatric inflammatory multisystem syndrome\"[tw]) OR (\"Long COVID\"[ot] OR \"post-acute sequelae of SARS-CoV-2\"[ot])) AND ((\"Cognition\"[Majr:NoExp] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurocognitive Disorders\"[Majr:NoExp] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Attention\"[Majr:NoExp] OR \"Mental Fatigue\"[Mesh] OR \"Neurologic Manifestations\"[Majr:NoExp] OR \"Neuropsychological Tests\"[Majr:NoExp]) OR (cognition[ti] OR cognitive[ti] OR memory[ti] OR \"executive function\"[ti]) OR (neurocognitive[tiab] OR \"cognitive impairment\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive decline\"[tiab] OR \"cognitive deficit*\"[tiab] OR \"cognitive symptom*\"[tiab] OR \"memory impairment\"[tiab] OR \"brain fog\"[tiab] OR neuropsychological[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic symptom*\"[tiab] OR \"neurological manifestation*\"[tiab] OR \"neurologic manifestation*\"[tiab] OR \"neuro-PASC\"[tiab]) OR (cognition[ot] OR memory[ot] OR \"executive function\"[ot] OR \"cognitive impairment\"[ot] OR \"brain fog\"[ot] OR neurology[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (vaccin*[ti] OR immunization[ti] OR immunisation[ti] OR \"breakthrough infection*\"[ti]) OR (vaccin*[tiab] OR \"breakthrough infection*\"[tiab] OR BNT162b2[tiab] OR \"mRNA-1273\"[tiab] OR ChAdOx1[tiab] OR \"Ad26.COV2.S\"[tiab]) OR (vaccin*[ot] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND english[la] AND 2020:3000[dp]",
            "issues": [],
            "display": "19 AND english[la] AND 2020:3000[dp]",
            "countedAt": "2026-10-28T12:23:27.102Z",
            "diagnostics": {
              "fieldsNotFound": [],
              "outputMessages": [],
              "phrasesIgnored": [],
              "translationSet": [],
              "phrasesNotFound": [],
              "queryTranslation": "(((\"covid 19\"[MeSH Major Topic] OR \"post acute covid 19 syndrome\"[MeSH Major Topic] OR \"sars cov 2\"[MeSH Major Topic] OR \"pediatric multisystem inflammatory disease covid 19 related\"[Supplementary Concept] OR (\"covid 19\"[Title] OR \"COVID19\"[Title] OR \"covid 19\"[Title] OR \"sars cov 2\"[Title] OR \"sars cov 2\"[Title] OR \"SARS-CoV-2 Infection\"[Title] OR \"Coronavirus Disease 2019\"[Title] OR \"2019 novel coronavirus\"[Title] OR \"Long COVID\"[Title] OR \"Post-COVID Conditions\"[Title] OR \"post-COVID-19 condition\"[Title] OR \"post-acute sequelae of SARS-CoV-2\"[Title] OR \"post acute covid 19 syndrome\"[Title] OR \"long-haul COVID\"[Title] OR \"post-COVID\"[Title]) OR \"MIS-C\"[Title/Abstract] OR (\"multisystem inflammatory syndrome in children\"[Text Word] OR \"paediatric inflammatory multisystem syndrome\"[Text Word]) OR (\"Long COVID\"[Other Term] OR \"post-acute sequelae of SARS-CoV-2\"[Other Term])) AND (\"Cognition\"[MeSH Major Topic:noexp] OR \"Cognitive Dysfunction\"[MeSH Terms] OR \"Neurocognitive Disorders\"[MeSH Major Topic:noexp] OR \"memory, episodic\"[MeSH Terms] OR \"memory, short term\"[MeSH Terms] OR \"Memory Disorders\"[MeSH Terms] OR \"Executive Function\"[MeSH Terms] OR \"Attention\"[MeSH Major Topic:noexp] OR \"Mental Fatigue\"[MeSH Terms] OR \"Neurologic Manifestations\"[MeSH Major Topic:noexp] OR \"Neuropsychological Tests\"[MeSH Major Topic:noexp] OR (\"Cognition\"[Title] OR \"cognitive\"[Title] OR \"memory\"[Title] OR \"Executive Function\"[Title]) OR (\"neurocognitive\"[Title/Abstract] OR \"cognitive impairment\"[Title/Abstract] OR \"Cognitive Dysfunction\"[Title/Abstract] OR \"cognitive decline\"[Title/Abstract] OR \"cognitive deficit*\"[Title/Abstract] OR \"cognitive symptom*\"[Title/Abstract] OR \"memory impairment\"[Title/Abstract] OR \"brain fog\"[Title/Abstract] OR \"neuropsychological\"[Title/Abstract] OR \"neurological symptom*\"[Title/Abstract] OR \"neurologic symptom*\"[Title/Abstract] OR \"neurological manifestation*\"[Title/Abstract] OR \"neurologic manifestation*\"[Title/Abstract] OR \"neuro-PASC\"[Title/Abstract]) OR (\"Cognition\"[Other Term] OR \"memory\"[Other Term] OR \"Executive Function\"[Other Term] OR \"cognitive impairment\"[Other Term] OR \"brain fog\"[Other Term] OR \"neurology\"[Other Term])) AND (\"COVID-19 Vaccines\"[MeSH Major Topic] OR \"Vaccination\"[MeSH Major Topic] OR \"Breakthrough Infections\"[MeSH Major Topic] OR \"COVID-19 breakthrough infections\"[Supplementary Concept] OR (\"vaccin*\"[Title] OR \"immunization\"[Title] OR \"immunisation\"[Title] OR \"breakthrough infection*\"[Title]) OR (\"vaccin*\"[Title/Abstract] OR \"breakthrough infection*\"[Title/Abstract] OR \"BNT162b2\"[Title/Abstract] OR \"mRNA-1273\"[Title/Abstract] OR \"ChAdOx1\"[Title/Abstract] OR \"Ad26.COV2.S\"[Title/Abstract]) OR (\"vaccin*\"[Other Term] OR \"breakthrough infection*\"[Other Term]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND \"english\"[Language] AND 2020/01/01:3000/12/31[Date - Publication]",
              "quotedPhrasesNotFound": []
            }
          }
        ]
      }
    },
    {
      "seq": 29,
      "event": {
        "type": "stage",
        "stage": "checking_seeds",
        "message": "Checking which known studies the final query finds"
      }
    },
    {
      "seq": 30,
      "event": {
        "type": "recall",
        "recall": {
          "k": 4,
          "n": 6,
          "lower": 0.22277809550351207,
          "seeds": [
            {
              "pmid": "38918610",
              "role": "validation",
              "input": "38918610",
              "retrieved": true,
              "resolvedBy": "pmid"
            },
            {
              "pmid": "38130975",
              "role": "validation",
              "input": "38130975",
              "retrieved": true,
              "resolvedBy": "pmid"
            },
            {
              "pmid": "39857653",
              "role": "development",
              "input": "39857653",
              "retrieved": true,
              "resolvedBy": "pmid"
            },
            {
              "pmid": "40144475",
              "role": "validation",
              "input": "40144475",
              "retrieved": true,
              "resolvedBy": "pmid"
            },
            {
              "pmid": "39787799",
              "role": "validation",
              "input": "39787799",
              "retrieved": true,
              "resolvedBy": "pmid"
            },
            {
              "pmid": "39657038",
              "role": "validation",
              "input": "39657038",
              "retrieved": false,
              "excludedBy": [
                "neuro"
              ],
              "resolvedBy": "pmid"
            },
            {
              "pmid": "39777257",
              "role": "development",
              "input": "10.1093/braincomms/fcae448",
              "retrieved": true,
              "resolvedBy": "doi"
            },
            {
              "pmid": null,
              "role": "validation",
              "input": "Cognition and Memory after Covid-19 in a Large Community Sample",
              "title": "Cognition and Memory after Covid-19 in a Large Community Sample",
              "resolvedBy": null
            },
            {
              "pmid": "35447302",
              "role": "validation",
              "input": "Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections",
              "title": "Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections",
              "retrieved": false,
              "excludedBy": [
                "neuro"
              ],
              "resolvedBy": "title"
            }
          ],
          "upper": 0.9567281317072582
        }
      }
    },
    {
      "seq": 31,
      "event": {
        "type": "stage",
        "stage": "comparing_reference",
        "message": "Comparing with the reference strategy"
      }
    },
    {
      "seq": 32,
      "event": {
        "type": "reference",
        "reference": {
          "overlapCount": 391,
          "generatedCount": 1072,
          "referenceCount": 521,
          "referenceQuery": "((((COVID-19[Majr] OR Post-Acute COVID-19 Syndrome[Majr] OR \"pediatric multisystem inflammatory disease, COVID-19 related\"[Supplementary Concept]) OR (\"COVID 19\"[ti] OR \"SARS Coronavirus 2 Infection\"[ti] OR \"2019-nCoV Infection\"[ti] OR \"2019 nCoV Infection\"[ti] OR \"2019-nCoV Infections\"[ti] OR \"Infection 2019-nCoV\"[ti] OR \"SARS-CoV-2 Infection\"[ti] OR \"Infection SARS-CoV-2\"[ti] OR \"SARS CoV 2 Infection\"[ti] OR \"SARS-CoV-2 Infections\"[ti] OR \"2019 Novel Coronavirus Disease\"[ti] OR \"2019 Novel Coronavirus Infection\"[ti] OR \"2019-nCoV Disease\"[ti] OR \"2019 nCoV Disease\"[ti] OR \"Disease 2019-nCoV\"[ti] OR \"COVID19\"[ti] OR \"Coronavirus Disease 2019\"[ti] OR \"Severe Acute Respiratory Syndrome Coronavirus 2 Infection\"[ti] OR \"COVID-19 Virus Disease\"[ti] OR \"COVID 19 Virus Disease\"[ti] OR \"Virus Disease COVID-19\"[ti] OR \"Coronavirus Disease-19\"[ti] OR \"Coronavirus Disease 19\"[ti] OR \"COVID-19 Virus Infection\"[ti] OR \"COVID 19 Virus Infection\"[ti] OR \"COVID-19 Virus Infections\"[ti] OR \"Virus Infection COVID-19\"[ti]) OR (\"Long COVID\"[ti] OR \"Long Haul COVID-19\"[ti] OR \"Long-Haul COVID\"[ti] OR \"Neuro PASC\"[ti] OR \"Post Acute COVID-19 Syndrome\"[ti] OR \"Post COVID-19 Syndrome\"[ti] OR \"Post-Acute COVID-19 Sequelae\"[ti] OR \"Post-Acute Sequelae SARS-CoV-2 Infection\"[ti] OR \"Post-COVID Conditions\"[ti] OR \"Post-COVID-19 Syndrome\"[ti]) OR (multisystem inflammatory syndrome in children[tw])) AND ((Cognition[Majr:noexp] OR Sensation[Majr:noexp] OR \"Psychomotor Performance\"[Mesh] OR \"Attention\"[Majr:noexp] OR \"Memory\"[Majr:noexp] OR \"Deja Vu\"[Mesh] OR \"Memory, Episodic\"[Mesh] OR \"Memory, Long-Term\"[Mesh] OR \"Memory, Short-Term\"[Mesh] OR \"Mental Recall\"[Mesh] OR \"Recognition, Psychology\"[Mesh] OR \"Repetition Priming\"[Mesh] OR \"Retention, Psychology\"[Mesh] OR \"Spatial Memory\"[Mesh] OR \"Executive Function\"[Mesh] OR \"Clinical Reasoning\"[Mesh] OR \"Problem Solving\"[Mesh] OR \"Processing Speed\"[Mesh] OR \"Language Development\"[Mesh] OR \"Cognitive Dysfunction\"[Mesh] OR \"Neurodevelopment\"[Mesh] OR \"Neuropathology\"[Mesh] OR \"Memory Disorders\"[Mesh] OR \"Brain\"[Mesh] OR \"Neurologic Manifestations\"[Majr:noexp]) OR (cognition[ti] OR \"cognitive function\"[ti] OR sensation[ti] OR \"sensory function\"[ti] OR \"sensory processing\"[ti] OR \"psychomotor performance\"[ti] OR \"sensory motor performance\"[ti] OR attention[ti] OR \"mental concentration\"[ti] OR memory[ti] OR \"immediate recall\"[ti] OR \"mental recall\"[ti] OR \"repetition priming\"[ti] OR \"executive function\"[ti] OR \"executive control\"[ti] OR \"clinical reasoning\"[ti] OR \"clinical judgement\"[ti] OR \"problem solving\"[ti] OR \"processing speed\"[ti] OR \"language development\"[ti] OR \"language acquisition\"[ti] OR \"cognitive defect\"[tiab] OR \"cognitive dysfunction\"[tiab] OR \"cognitive impairment\"[tiab] OR neurodevelopment[ti] OR neuropathology[ti] OR neurocognitive[tiab] OR brain[ti] OR neurocognition[tiab] OR \"neurological symptom*\"[tiab] OR \"neurologic disorder*\"[tiab] OR \"neurological disorder*\"[tiab]) OR (cognition[ot] OR \"cognitive function\"[ot] OR sensation[ot] OR \"sensory function\"[ot] OR \"sensory processing\"[ot] OR \"psychomotor performance\"[ot] OR \"sensory motor performance\"[ot] OR attention[ot] OR \"mental concentration\"[ot] OR memory[ot] OR \"immediate recall\"[ot] OR \"mental recall\"[ot] OR \"psychological recognition\"[ot] OR \"repetition priming\"[ot] OR \"executive function\"[ot] OR \"executive control\"[ot] OR \"clinical reasoning\"[ot] OR \"clinical judgement\"[ot] OR \"problem solving\"[ot] OR \"processing speed\"[ot] OR \"language development\"[ot] OR \"language acquisition\"[ot] OR \"cognitive defect\"[ot] OR \"cognitive dysfunction\"[ot] OR \"cognitive impairment\"[ot] OR neurodevelopment[ot] OR neuropathology[ot] OR neurocognitive[ot] OR brain[ot] OR neurocognition[ot] OR \"neurological symptom*\"[ot] OR \"neurologic disorder*\"[ot] OR \"neurological disorder*\"[ot])) AND ((\"COVID-19 Vaccines\"[Majr] OR \"Vaccination\"[Majr] OR \"Breakthrough Infections\"[Majr] OR \"COVID-19 breakthrough infections\"[Supplementary Concept]) OR (\"COVID 19 Vaccines\"[ti] OR \"Vaccines COVID-19\"[ti] OR \"Coronavirus Disease 2019 Vaccines\"[ti] OR \"Coronavirus Disease 2019 Vaccine\"[ti] OR \"Coronavirus Disease-19 Vaccines\"[ti] OR \"Coronavirus Disease 19 Vaccines\"[ti] OR \"Coronavirus Disease-19 Vaccine\"[ti] OR \"Coronavirus Disease 19 Vaccine\"[ti] OR \"COVID 19 Vaccine\"[ti] OR \"Vaccine COVID 19\"[ti] OR \"2019-nCoV Vaccine\"[ti] OR \"SARS-CoV-2 Vaccine\"[ti] OR \"SARS CoV 2 Vaccine\"[ti] OR \"Vaccine SARS-CoV-2\"[ti] OR \"COVID-19 Vaccine\"[ti] OR \"SARS Coronavirus 2 Vaccines\"[ti] OR \"Virus Vaccines COVID-19\"[ti] OR \"COVID19 Vaccine\"[ti] OR \"SARS-CoV-2 Vaccines\"[ti] OR \"SARS CoV 2 Vaccines\"[ti] OR \"Vaccines SARS-CoV-2\"[ti] OR vaccination[ti] OR vaccination[ot] OR \"breakthrough infection*\"[ti] OR \"breakthrough infection*\"[ot]))) NOT (\"Comment\"[Publication Type] OR \"Case Reports\"[Publication Type] OR \"Conference Proceedings\"[Publication Type] OR \"Editorial\"[Publication Type] OR \"Preprint\"[Publication Type])) AND english[la]",
          "relativeRecall": 0.7504798464491362
        }
      }
    },
    {
      "seq": 33,
      "event": {
        "type": "stage",
        "stage": "fetching_records",
        "message": "Fetching the first 20 records"
      }
    },
    {
      "seq": 34,
      "event": {
        "type": "records",
        "total": 1072,
        "records": [
          {
            "pmid": "42943491",
            "year": "2026",
            "title": "SARS-CoV-2 Breakthrough Infection Reveals Platform-Associated Long-Term Immune Remodeling in a Central Asian Cohort.",
            "authors": "Akhmaltdinova L, Bekbossynova M, Dossybayeva K et al.",
            "journal": "Microorganisms"
          },
          {
            "pmid": "42923005",
            "year": "2026",
            "title": "EpiFloripa COVID-Tel: methods and results of the telephone survey on the COVID-19 pandemic among older adults participating in the 2017-2019 and 2021-2022 EpiFloripa cohort study.",
            "authors": "Funk E, Hillesheim D, Figueiró TH et al.",
            "journal": "Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil"
          },
          {
            "pmid": "42905886",
            "year": "2026",
            "title": "Protective Effect of COVID-19 Vaccination on Post-Infection Visuospatial Deficits.",
            "authors": "da Silva LG, Fini BCD, Oliveira JCM et al.",
            "journal": "Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)"
          },
          {
            "pmid": "42900956",
            "year": "2026",
            "title": "Protective Effect of COVID-19 Vaccination on Post-Infection Visuospatial Deficits.",
            "authors": "da Silva LG, Fini BCD, Oliveira JCM et al.",
            "journal": "Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)"
          },
          {
            "pmid": "42881804",
            "year": "2026",
            "title": "Self-Rated Health and Persistent Symptoms Among Adults Reporting Previous SARS-CoV-2 Infection: A Cross-Sectional Study.",
            "authors": "Weber D, Łuczyk RJ, Pacian A et al.",
            "journal": "Journal of clinical medicine"
          },
          {
            "pmid": "42863757",
            "year": "2026",
            "title": "Circulating SARS-CoV-2 RNA detection in acute COVID-19 disease and post-COVID condition.",
            "authors": "Rovito R, Terracciano L, De Pinto G et al.",
            "journal": "Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases"
          },
          {
            "pmid": "42841133",
            "year": "2026",
            "title": "Prior COVID-19 vaccination and cognitive outcomes after SARS-CoV-2 infection: a mini-review.",
            "authors": "da Silva LG, Oliveira JCM, Fini BCD et al.",
            "journal": "Dementia & neuropsychologia"
          },
          {
            "pmid": "42836482",
            "year": "2026",
            "title": "Immune checkpoint inhibition enhances memory T-cell responses to CEF(T), SARS-CoV-2 spike proteins and ChAdOx1 nCoV-19.",
            "authors": "Grice S, Gardner J, Thomson P et al.",
            "journal": "Human vaccines & immunotherapeutics"
          },
          {
            "pmid": "42750672",
            "year": "2026",
            "title": "Memory B cell response to SARS-CoV-2 vaccination in people with heart and lung transplantation: Identification of associated clinical factors.",
            "authors": "Coppola C, Costagli S, Montesi G et al.",
            "journal": "iScience"
          },
          {
            "pmid": "42718410",
            "year": "2024",
            "title": "SARS-CoV-2 memory response in non-hospitalised cases: immunology in the context of a population-based cohort study.",
            "authors": "Mitchell RE, Kibble M, Santopaolo M et al.",
            "journal": "Wellcome open research"
          },
          {
            "pmid": "42705227",
            "year": "2026",
            "title": "Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection.",
            "authors": "Zhang Q, Chen P, Guo F et al.",
            "journal": "Immunity"
          },
          {
            "pmid": "42675735",
            "year": "2026",
            "title": "Long-term adverse effects following COVID-19 vaccination: A comparative analysis of Oxford AstraZeneca, Pfizer-BioNTech, and Moderna vaccines.",
            "authors": "Aldali JA, Meo SA",
            "journal": "Medicine"
          },
          {
            "pmid": "42628376",
            "year": "2026",
            "title": "Role of plasmacytoid dendritic cells in humoural and CD8(+) T-cell memory responses following BNT162b2 mRNA vaccination: a preclinical mouse study.",
            "authors": "Pizzichetti C, Latino I, Virgilio T et al.",
            "journal": "EBioMedicine"
          },
          {
            "pmid": "42625910",
            "year": "2026",
            "title": "Differential functional immune recall across homologous and heterologous COVID-19 vaccination regimens.",
            "authors": "Che-Kamaruddin N, Johari J, Yahaya H et al.",
            "journal": "Frontiers in immunology"
          },
          {
            "pmid": "42599142",
            "year": "2026",
            "title": "Incidence and clinical characteristics of amyotrophic lateral sclerosis during the post-COVID-19 Period: a population-based study from Isfahan, Iran.",
            "authors": "Etemadifar M, Salari M, Kashefi M et al.",
            "journal": "Neurodegenerative disease management"
          },
          {
            "pmid": "42590004",
            "year": "2026",
            "title": "Determinants and Consequences of Long Impact of COVID-19: A National Cross-Sectional Study in Saudi Arabia.",
            "authors": "Alshomrani A, Hussaini AS, Miskeen E",
            "journal": "Journal of clinical medicine"
          },
          {
            "pmid": "42568479",
            "year": "2026",
            "title": "Conserved CD4 T-cell responses correlate with antibody neutralization in solid organ transplant recipients after bivalent SARS-CoV-2 vaccination.",
            "authors": "Stavrakis G, Roznik K, Stoddart L et al.",
            "journal": "Frontiers in immunology"
          },
          {
            "pmid": "42543573",
            "year": "2026",
            "title": "Long COVID symptom trajectories according to post-COVID-19 vaccination status: a prospective longitudinal study.",
            "authors": "Benli A, Ala Selek S, Başaran S et al.",
            "journal": "Japanese journal of infectious diseases"
          },
          {
            "pmid": "42543244",
            "year": "2026",
            "title": "Predicting parents' COVID-19 vaccination intentions and behavior for their children: application of an integrated social cognition model.",
            "authors": "Griffith ZM, Royer Z, Gaffney AM et al.",
            "journal": "Psychology & health"
          },
          {
            "pmid": "42522246",
            "year": "2026",
            "title": "The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.",
            "authors": "Kubo M",
            "journal": "Immunological reviews"
          }
        ]
      }
    },
    {
      "seq": 35,
      "event": {
        "type": "stage",
        "stage": "saving",
        "message": "Saving the run"
      }
    },
    {
      "seq": 36,
      "event": {
        "type": "done",
        "finalCount": 1072
      }
    }
  ]
}