PubMed: Provider: NLM Database: PubMed (National Library of Medicine), https://pubmed.ncbi.nlm.nih.gov Date(s) Searched: October 29, 2026 Publication types excluded: Comment, Editorial, Letter, Case Reports, Preprint, Review Animal-only studies excluded: animals[mh] NOT humans[mh] Final count: 1,039 (line 15) Search Terms: No. | Query | Results 1 | "Renal Insufficiency, Chronic"[Mesh] OR "Renal Insufficiency"[Mesh:NoExp] OR "Glomerular Filtration Rate"[Mesh] | 209,392 2 | "chronic kidney disease*"[tiab] OR CKD[tiab] OR "chronic renal failure"[tiab] OR "chronic kidney failure"[tiab] OR "chronic renal disease"[tiab] OR "renal insufficiency"[tiab] OR "kidney insufficiency"[tiab] OR "renal impairment"[tiab] OR "kidney impairment"[tiab] OR "renal dysfunction"[tiab] OR "kidney dysfunction"[tiab] OR "glomerular filtration rate"[tiab] OR eGFR[tiab] OR "creatinine clearance"[tiab] OR "kidney function"[tiab] OR "renal function"[tiab] | 415,812 3 | 1 OR 2 | 504,795 4 | "Myocardial Ischemia"[Mesh] | 503,270 5 | "coronary artery disease*"[tiab] OR "coronary disease*"[tiab] OR "coronary heart disease*"[tiab] OR "ischemic heart disease"[tiab] OR "ischaemic heart disease"[tiab] OR "myocardial ischemia"[tiab] OR "myocardial ischaemia"[tiab] OR "myocardial infarction"[tiab] OR angina[tiab] OR "acute coronary syndrome*"[tiab] OR "coronary stenosis"[tiab] OR "coronary occlusion"[tiab] OR "multivessel coronary"[tiab] OR NSTEMI[tiab] OR STEMI[tiab] | 519,062 6 | 4 OR 5 | 697,830 7 | "Myocardial Revascularization"[Mesh] OR "Percutaneous Coronary Intervention"[Mesh] OR "Coronary Artery Bypass"[Mesh] | 131,943 8 | revasculari*[tiab] OR "percutaneous coronary intervention*"[tiab] OR PCI[tiab] OR "coronary angioplasty"[tiab] OR "coronary stent*"[tiab] OR stenting[tiab] OR "coronary artery bypass"[tiab] OR CABG[tiab] OR "bypass surgery"[tiab] OR "invasive strateg*"[tiab] OR "invasive management"[tiab] OR "invasive treatment"[tiab] OR "invasive approach"[tiab] | 263,478 9 | 7 OR 8 | 298,517 10 | "Randomized Controlled Trials as Topic"[Mesh] OR "Clinical Trials as Topic"[Mesh] OR "Random Allocation"[Mesh] | 528,120 11 | random*[tiab] OR trial*[tiab] OR "post hoc"[tiab] OR "ISCHEMIA-CKD"[tiab] | 2,780,289 12 | 10 OR 11 | 2,982,529 13 | 3 AND 6 AND 9 AND 12 | 1,380 14 | "Comment"[Publication Type] OR "Editorial"[Publication Type] OR "Letter"[Publication Type] OR "Case Reports"[Publication Type] OR "Preprint"[Publication Type] OR "Review"[Publication Type] OR (animals[mh] NOT humans[mh]) | 14,004,986 15 | 13 NOT 14 | 1,039 16 | "Mortality"[Mesh] OR "Acute Kidney Injury"[Mesh] OR "Renal Dialysis"[Mesh] | 643,741 17 | mortality[tiab] OR death*[tiab] OR "major adverse cardiac event*"[tiab] OR MACE[tiab] OR "contrast induced nephropathy"[tiab] OR "acute kidney injury"[tiab] OR "kidney failure"[tiab] | 2,288,809 18 | 16 OR 17 | 2,640,713 Final query as run through NCBI E-utilities (line 15): ((("Renal Insufficiency, Chronic"[Mesh] OR "Renal Insufficiency"[Mesh:NoExp] OR "Glomerular Filtration Rate"[Mesh]) OR ("chronic kidney disease*"[tiab] OR CKD[tiab] OR "chronic renal failure"[tiab] OR "chronic kidney failure"[tiab] OR "chronic renal disease"[tiab] OR "renal insufficiency"[tiab] OR "kidney insufficiency"[tiab] OR "renal impairment"[tiab] OR "kidney impairment"[tiab] OR "renal dysfunction"[tiab] OR "kidney dysfunction"[tiab] OR "glomerular filtration rate"[tiab] OR eGFR[tiab] OR "creatinine clearance"[tiab] OR "kidney function"[tiab] OR "renal function"[tiab])) AND (("Myocardial Ischemia"[Mesh]) OR ("coronary artery disease*"[tiab] OR "coronary disease*"[tiab] OR "coronary heart disease*"[tiab] OR "ischemic heart disease"[tiab] OR "ischaemic heart disease"[tiab] OR "myocardial ischemia"[tiab] OR "myocardial ischaemia"[tiab] OR "myocardial infarction"[tiab] OR angina[tiab] OR "acute coronary syndrome*"[tiab] OR "coronary stenosis"[tiab] OR "coronary occlusion"[tiab] OR "multivessel coronary"[tiab] OR NSTEMI[tiab] OR STEMI[tiab])) AND (("Myocardial Revascularization"[Mesh] OR "Percutaneous Coronary Intervention"[Mesh] OR "Coronary Artery Bypass"[Mesh]) OR (revasculari*[tiab] OR "percutaneous coronary intervention*"[tiab] OR PCI[tiab] OR "coronary angioplasty"[tiab] OR "coronary stent*"[tiab] OR stenting[tiab] OR "coronary artery bypass"[tiab] OR CABG[tiab] OR "bypass surgery"[tiab] OR "invasive strateg*"[tiab] OR "invasive management"[tiab] OR "invasive treatment"[tiab] OR "invasive approach"[tiab])) AND (("Randomized Controlled Trials as Topic"[Mesh] OR "Clinical Trials as Topic"[Mesh] OR "Random Allocation"[Mesh]) OR (random*[tiab] OR trial*[tiab] OR "post hoc"[tiab] OR "ISCHEMIA-CKD"[tiab]))) NOT ("Comment"[Publication Type] OR "Editorial"[Publication Type] OR "Letter"[Publication Type] OR "Case Reports"[Publication Type] OR "Preprint"[Publication Type] OR "Review"[Publication Type] OR (animals[mh] NOT humans[mh])) AI-use statement: The PubMed search strategy was drafted with the PICO search builder. It used the large language model claude-opus-5-5 (Anthropic; accessed October 29, 2026) to propose search concepts and terms from the review question. The tool made 1 call to the model at high effort (the draft); claude-opus-5-5 was requested and answered it. A refusal fallback was enabled (had the model declined a request, the API could have run it again on another model Anthropic recommends); it was not used. Every MeSH heading, Supplementary Concept and publication type the strategy searches was checked against NLM MeSH (id.nlm.nih.gov) before use: 19 valid. Each numbered line was run in PubMed through NCBI E-utilities on October 29, 2026, and PubMed's own diagnostics (phrases not found, ignored words, lost truncation) were checked. The strategy was tested against 6 known relevant studies that were not shown to the model: 5 were retrieved (95% CI 36%–100%). Retrieving known studies does not prove the search is complete. 2 further known studies were shown to the model as examples. Compared with the reference strategy, the strategy retrieves 204 of the reference's 1,107 records (relative recall 18%). Relative recall counts every record the reference retrieves, relevant or not, so it does not show how many relevant studies the strategy finds. The run has 3 saved versions (AI draft, repairs and the searcher's edits). A searcher must review the strategy before it is used. The prompts, the model output and every version are in the provenance file (JSON export). Review question: In people with non-dialysis-dependent CKD and ischemic heart disease, does coronary revascularization (PCI or CABG) plus medical therapy, compared with medical therapy alone, reduce death, cardiovascular events or kidney harms in randomized trials? Run 15790b74-8a75-414c-9ae1-e911e28de799, exported October 29, 2026 from the PICO search builder.