PMID- 42952194 OWN - NLM STAT- MEDLINE DCOM- 20261029 LR - 20261029 IS - 1462-3994 (Electronic) IS - 1462-3994 (Linking) VI - 28 DP - 2026 Oct 29 TI - Evaluating Alignment of Prader-Willi Syndrome with the Australian Newborn Bloodspot Screening Criteria. PG - e52 LID - 10.1017/erm.2026.10080 [doi] AB - BACKGROUND: Prader-Willi syndrome (PWS) is a leading genetic cause of life-threatening obesity, presenting with hypotonia and feeding difficulties in infancy, progressing to hyperphagia, cognitive impairment and behavioural challenges from childhood. It is a rare imprinting disorder caused by gene silencing at the 15q11-q13 locus. Early detection through newborn bloodspot screening (NBS) could enable timely interventions such as growth hormone therapy, dietary management and behavioural support to improve health and developmental outcomes for the affected infants. METHODS: This review applies the Australian Newborn Bloodspot Screening National Policy Framework as a reference to evaluate the suitability of incorporating PWS into NBS programs. The review outlines benefits and challenges in relation to key criteria used by this Framework, including condition severity, early detection benefits and screening test reliability. RESULTS: Emerging screening technologies are recognised for their high sensitivity and specificity and could be integrated into existing NBS workflows using dried blood spots. However, several challenges outlined in this review need to be addressed, including the lack of cost-effectiveness data for population-wide PWS screening programs and the absence of a curative treatment for PWS. CONCLUSION: Expanding NBS to include PWS has the potential to improve health and developmental outcomes through earlier diagnosis and timely interventions. Successful implementation will depend on addressing the remaining challenges. FAU - Alshawsh, Mohammed A AU - Alshawsh MA AUID- ORCID: 0000-0001-8342-5183 AD - Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia. AD - Department of Paediatrics, Monash University, Clayton, VIC, Australia. ROR: https://ror.org/019wvm592 FAU - Tennakoon, Oshadi AU - Tennakoon O AUID- ORCID: 0009-0006-2052-4305 AD - Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University, ACT, Australia. ROR: https://ror.org/03f0f6041 FAU - Arora, Sheena AU - Arora S AUID- ORCID: 0000-0002-7562-2416 AD - Centre for Health Economics Research and Evaluation, University of Technology Sydney, Broadway, NSW, Australia. ROR: https://ror.org/03f0f6041 FAU - Greaves, Ronda F AU - Greaves RF AUID- ORCID: 0000-0001-7823-8797 AD - Department of Paediatrics, Monash University, Clayton, VIC, Australia. ROR: https://ror.org/019wvm592 AD - Victorian Clinical Genetics Services,Murdoch Children's Research Institute, Parkville, VIC, Australia. AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. FAU - Cheong, Jeanie AU - Cheong J AUID- ORCID: 0000-0001-5901-0455 AD - Department of Paediatrics, Monash University, Clayton, VIC, Australia. ROR: https://ror.org/019wvm592 AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. AD - Department of Obstetrics, Gynaecology and Newborn Health, The Royal Women's Hospital, Parkville, VIC, Australia. FAU - Williams, Katrina AU - Williams K AUID- ORCID: 0000-0002-1686-4458 AD - Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia. AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. FAU - Godler, David E AU - Godler DE AUID- ORCID: 0000-0002-6405-269X AD - Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia. AD - Department of Paediatrics, Monash University, Clayton, VIC, Australia. ROR: https://ror.org/019wvm592 AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. LA - eng GR - No. 1049299 and No. 1103389/National Health and Medical Research Council/ GR - 2017-361/Financial Markets Foundation for Children/ PT - Journal Article PT - Review DEP - 20261029 PL - England TA - Expert Rev Mol Med JT - Expert reviews in molecular medicine JID - 100939725 SB - IM MH - Humans MH - *Prader-Willi Syndrome/diagnosis/genetics/blood/epidemiology MH - *Neonatal Screening/methods MH - Infant, Newborn MH - Australia/epidemiology MH - Genetic Testing/methods OTO - NOTNLM OT - Australian decision-making criteria OT - DNA methylation testing OT - Prader-Willi syndrome OT - chromosome 15 imprinting disorders OT - newborn bloodspot screening EDAT- 2026/10/29 05:30 MHDA- 2026/10/29 05:31 CRDT- 2026/10/29 02:23 PHST- 2026/10/29 05:31 [medline] PHST- 2026/10/29 05:30 [pubmed] PHST- 2026/10/29 02:23 [entrez] AID - S1462399426100805 [pii] AID - 10.1017/erm.2026.10080 [doi] PST - epublish SO - Expert Rev Mol Med. 2026 Oct 29;28:e52. doi: 10.1017/erm.2026.10080. PMID- 42951837 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1476-4954 (Electronic) IS - 1476-4954 (Linking) VI - 39 IP - 1 DP - 2026 Dec TI - Association of third-trimester maternal lipid levels with adverse pregnancy outcomes in women with gestational diabetes mellitus: a retrospective single-center study using intrapartum data. PG - 2751278 LID - 10.1080/14767058.2026.2751278 [doi] AB - OBJECTIVES: This study investigates the relationships between maternal factors and gestational diabetes mellitus (GDM), as well as third‑trimester maternal lipids and adverse pregnancy outcomes among GDM patients. METHODS: This study enrolled 3,973 pregnant women, divided into a control group (n = 3166) and a GDM group (n = 807). The GDM group was further divided into well-controlled (n = 152) and poorly controlled subgroups (n = 655). Univariate and multivariate logistic regression analyses were performed to evaluate factors associated with GDM risk. Baseline clinical/laboratory characteristics were compared across groups via parametric, nonparametric, and chi‑square tests to assess associations of third‑trimester maternal lipid levels with adverse pregnancy outcomes. Receiver operating characteristic analyses evaluated the predictive values of body mass index (BMI) and third‑trimester maternal lipid levels. RESULTS: Age (OR = 1.069, 95% CI:1.050-1.087, p < .001), overweight (OR = 1.678 95% CI:1.396-2.013, p < .001), and obesity (OR = 2.018, 95% CI:1.511-2.677, p < .001) are key risk factors for GDM. Significant differences existed in age (p = .001), BMI (p < .001), fasting blood glucose (FBG, p < .001) and 2-hour postprandial plasma glucose (2hPPG, p = .001) across subgroups, as well as triglycerides (TG, p < .001), high-density lipoprotein cholesterol (HDL-C, p = .001), and free fatty acids (FFAs, p < .001) among the three groups. Subgroup analysis by lipid levels showed TG predominantly affected delivery mode (p = .031), neonatal birth weight (p = .005), and quantitative blood loss (QBL, p = .019) in GDM, while HDL-C mainly influenced fetal growth curve (p = .004) and neonatal birth weight (p = .002). Subgroup analysis by triglyceride-glucose index (TyG index) revealed significant differences in glycemic control (p = .002), delivery mode (p = .002), neonatal weight (p = .005), and QBL (p = .005). The area under the curve of pre-pregnancy BMI for GDM complicated by hypertensive disorders of pregnancy was 0.738, third-trimester BMI 0.720, and 0.709 for macrosomia prediction in non-advanced-age women with GDM. CONCLUSION: Age, overweight, and obesity are independent risk factors for GDM. Among women with GDM, third-trimester lipid levels are associated with adverse pregnancy outcomes. Therefore, lipid levels should be considered in GDM clinical management, rather than focusing exclusively on glycemic control. FAU - Yang, Yuqi AU - Yang Y AUID- ORCID: 0000-0002-7619-9541 AD - Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China. AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. FAU - Peng, Yue AU - Peng Y AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. FAU - Fan, Jiuxiang AU - Fan J AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. FAU - Zhang, Jian AU - Zhang J AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. FAU - Zhu, Wei AU - Zhu W AUID- ORCID: 0000-0002-5237-1992 AD - Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China. FAU - Yu, Bin AU - Yu B AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. LA - eng PT - Journal Article DEP - 20261028 PL - England TA - J Matern Fetal Neonatal Med JT - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JID - 101136916 RN - 0 (Lipids) RN - 0 (Triglycerides) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/blood/epidemiology MH - Adult MH - Retrospective Studies MH - *Pregnancy Outcome/epidemiology MH - *Pregnancy Trimester, Third/blood MH - *Lipids/blood MH - Body Mass Index MH - Risk Factors MH - Case-Control Studies MH - Triglycerides/blood MH - Infant, Newborn OTO - NOTNLM OT - Gestational diabetes mellitus OT - high-density lipoprotein cholesterol OT - lipid metabolism OT - triglyceride OT - triglyceride-glucose index EDAT- 2026/10/29 05:30 MHDA- 2026/10/29 05:31 CRDT- 2026/10/28 23:23 PHST- 2026/10/29 05:31 [medline] PHST- 2026/10/29 05:30 [pubmed] PHST- 2026/10/28 23:23 [entrez] AID - 10.1080/14767058.2026.2751278 [doi] PST - ppublish SO - J Matern Fetal Neonatal Med. 2026 Dec;39(1):2751278. doi: 10.1080/14767058.2026.2751278. Epub 2026 Oct 28. PMID- 42950072 OWN - NLM STAT- Publisher LR - 20261028 IS - 1536-0911 (Electronic) IS - 1536-0903 (Linking) DP - 2026 Oct 27 TI - Predictors and Risk Factors of Necrotizing Enterocolitis: An Integrative Review. LID - 10.1097/ANC.0000000000001441 [doi] AB - BACKGROUND: Necrotizing enterocolitis (NEC) is associated with high morbidity and mortality among preterm infants. Early intervention is critical, but existing predictors and risk factors remain inconsistent. Integrating bedside nursing assessments with machine learning (ML) may enable prediction of NEC before deterioration. PURPOSE: This integrative review synthesizes evidence on predictors and risk factors of NEC in very low birth weight (VLBW; <1500 g) infants to guide ML-based prediction models, support nursing assessment, and support early clinical decision making. DATA SOURCES: MEDLINE, CINAHL, and Embase. STUDY SELECTION: We included quantitative studies published from 2015 to 2025, involving VLBW infants <32 weeks gestation and examining NEC predictors or risk factors. From 405 records, 325 abstracts were screened, and 14 studies met inclusion criteria. DATA EXTRACTION: Two reviewers independently assessed full texts, resolving differences through consensus. Data were organized thematically using an inductive approach with a predetermined extraction table. Study quality was evaluated with a Joanna Briggs Institute tool. RESULTS: Across 14 studies, 55 predictors or risk factors were identified. Gestational age, birth weight, and human milk exposure were consistently associated with NEC risk. Other maternal, antenatal, delivery, nutritional, social, and clinical variables varied widely, with only 16 factors appearing in multiple studies. Most studies used retrospective cohort designs, and one incorporated ML methods. IMPLICATIONS FOR PRACTICE AND RESEARCH: Nurses are central to NEC prevention through human milk promotion, risk surveillance, and bedside advocacy. Future NEC prediction should integrate dynamic, contextual variables with standardized definitions and validation across diverse settings. CI - Copyright (c) 2026 by The National Association of Neonatal Nurses. FAU - Fordham, Keliy AU - Fordham K AUID- ORCID: 0000-0002-0286-596 AD - Author Affiliations: College of Nursing, University of Florida, Gainesville, FL (Fordham, Monk, Bjarnadottir, Yao, and Parker); Tampa General Hospital, Tampa, Florida (Cousin); and College of Industrial and Systems Engineering, University of Florida, Gainesville, Florida (Zhong). FAU - Monk, Angela AU - Monk A FAU - Bjarnadottir, Ragnhildur I AU - Bjarnadottir RI FAU - Cousin, Lakeshia AU - Cousin L FAU - Zhong, Xiang AU - Zhong X FAU - Yao, Yingwei AU - Yao Y FAU - Parker, Leslie A AU - Parker LA LA - eng PT - Journal Article DEP - 20261027 PL - United States TA - Adv Neonatal Care JT - Advances in neonatal care : official journal of the National Association of Neonatal Nurses JID - 101125644 SB - IM OTO - NOTNLM OT - infant OT - machine learning OT - necrotizing enterocolitis OT - nursing assessment OT - risk factors OT - very low birth weight EDAT- 2026/10/28 17:31 MHDA- 2026/10/28 17:31 CRDT- 2026/10/28 14:04 PHST- 2026/10/28 17:31 [medline] PHST- 2026/10/28 17:31 [pubmed] PHST- 2026/10/28 14:04 [entrez] AID - 00149525-990000000-00327 [pii] AID - 10.1097/ANC.0000000000001441 [doi] PST - aheadofprint SO - Adv Neonatal Care. 2026 Oct 27. doi: 10.1097/ANC.0000000000001441. PMID- 42948496 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261028 LR - 20261028 IS - 2639-6378 (Electronic) IS - 2639-6378 (Linking) VI - 12 IP - 4 DP - 2026 Oct TI - Building a Sustainable Teen Wellness Curriculum in a Faith-Based Community Setting : A Six-Year Program Evaluation in Wilmington, Delaware. PG - 79-81 LID - 10.32481/djph.2026.10.10 [doi] AB - In the United States, the need for adolescent mental health support is greater than what clinical services can provide, with about one in five teens reporting unmet needs. Faith-based organizations are trusted and easy to access, but evidence on sustained delivery is limited. This report looks at a volunteer-led teen wellness program at Manna House Fellowship in Wilmington, Delaware, which ran from June 2020 to July 2026. The program offered 30-minute interactive small-group sessions every two weeks during active cycles, focusing on sleep, nutrition, physical activity, screen and social media use, and stress coping. Sessions were held online until March 2022, then in person. Over six years, 78 sessions reached 35 different teens, averaging eight participants per session, with most attending more than once. Anonymous feedback was collected monthly in written and verbal formats, and reported changes were noted. No one needed to be referred to formal mental health services. That the program has continued for six years without outside funding or paid staff support the feasibility of this sustained community wellness program, although not its clinical effectiveness. Zero recorded referrals do not establish an absence of unmet mental health needs. CI - 2026 The journal and its content is copyrighted by the Delaware Academy of Medicine & Public Health (the Academy). FAU - Nathaniel, Sangeetha D AU - Nathaniel SD AD - Delaware Heart and Vascular Group, Delaware. AD - Manna House Fellowship, Delaware. AD - ChristianaCare Hospital, Delaware. FAU - Innasimuthu, Michelle AU - Innasimuthu M AD - Delaware Heart and Vascular Group, Delaware. AD - Manna House Fellowship, Delaware. AD - ChristianaCare Hospital, Delaware. FAU - Gnanaguruparan, Subramanian AU - Gnanaguruparan S AD - Delaware Heart and Vascular Group, Delaware. AD - Manna House Fellowship, Delaware. AD - ChristianaCare Hospital, Delaware. LA - eng PT - Journal Article DEP - 20261026 PL - United States TA - Dela J Public Health JT - Delaware journal of public health JID - 101769648 PMC - PMC13712908 EDAT- 2026/10/28 11:36 MHDA- 2026/10/28 11:37 PMCR- 2026/10/26 CRDT- 2026/10/28 05:35 PHST- 2026/10/28 11:37 [medline] PHST- 2026/10/28 11:36 [pubmed] PHST- 2026/10/28 05:35 [entrez] PHST- 2026/10/26 00:00 [pmc-release] AID - djph-124-10 [pii] AID - 10.32481/djph.2026.10.10 [doi] PST - epublish SO - Dela J Public Health. 2026 Oct 26;12(4):79-81. doi: 10.32481/djph.2026.10.10. eCollection 2026 Oct. PMID- 42948365 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261028 LR - 20261028 IS - 1792-1015 (Electronic) IS - 1792-0981 (Print) IS - 1792-0981 (Linking) VI - 32 IP - 6 DP - 2026 Dec TI - Associations of reticulocyte hemoglobin equivalent with erythrocyte indices and serum ferritin in anemic patients with hepatocellular carcinoma: A retrospective study. PG - 340 LID - 10.3892/etm.2026.13335 [doi] LID - 340 AB - Cancer-related anemia is common in patients with hepatocellular carcinoma (HCC), and its pathogenesis is complex due to the coexistence of chronic liver disease, portal hypertension, hypersplenism, inflammation, nutritional disorders and tumor-related factors. The present retrospective study characterized anemia morphology in 96 anemic patients with HCC before initiation of their first antitumor therapy, and examined the associations of reticulocyte hemoglobin equivalent (RET-He) with erythrocyte indices and serum ferritin (SF), with a focus on whether RET-He and SF displayed distinct patterns of association with hematological parameters. The data collected included sex, age, Barcelona Clinic Liver Cancer stage, Child-Pugh grade, splenomegaly/hypersplenism, hemoglobin (Hb) concentration, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), MCH concentration (MCHC), absolute reticulocyte count (RET#), RET-He and SF. Patients were compared by anemia severity, morphological type and RET-He level, and Spearman'a correlation was used to assess relationships between RET-He and other parameters. Mild, moderate and severe anemia occurred in 41 (42.71%), 52 (54.17%) and 3 (3.13%) patients, respectively. Macrocytic, normocytic, simple microcytic and microcytic hypochromic anemia were found in 29 (30.21%), 40 (41.67%), 5 (5.21%) and 22 (22.92%) patients, respectively. A total of 26 patients (27.08%) had RET-He 2 years), bottle-feeding, and inadequate oral hygiene practices (infrequent or unsupervised brushing and use of non-fluoridated toothpaste) were identified as key behavioral indicators significantly associated with increased S-ECC (P < 0.05). Furthermore, lower nutritional status and higher defs indices were strongly associated with poorer OHRQoL scores (P < 0.001). CONCLUSIONS: S-ECC and poor nutrition were prevalent among 4-5-year-olds, strongly associated with dietary habits, oral hygiene practices, and maternal education, while both conditions correlated with lower oral health-related quality of life. Importantly, higher ECC and poor nutrition were interrelated, highlighting the potential utility of integrated oral health and nutritional interventions in clinical pediatric settings. CI - (c) 2026. The Author(s). FAU - Nadeeshani, Harshani AU - Nadeeshani H AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. AD - Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Narada, Malinda AU - Narada M AD - Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Gunawardena, Sadhisha AU - Gunawardena S AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. FAU - De Alwis, Sudam AU - De Alwis S AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. FAU - Dias, Chathumini AU - Dias C AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. FAU - Kudagammana, Sanath Thushara AU - Kudagammana ST AD - Department of Paediatrics, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Herath, Chandra AU - Herath C AD - Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Jayasinghe, Ruwan AU - Jayasinghe R AD - Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Liyanage, Ruvini AU - Liyanage R AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. ruvini.li@nifs.ac.lk. LA - eng PT - Journal Article DEP - 20260723 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Child, Preschool MH - Cross-Sectional Studies MH - *Quality of Life MH - Female MH - Male MH - *Dental Caries/epidemiology MH - *Oral Health/statistics & numerical data MH - *Nutritional Status MH - Sri Lanka/epidemiology MH - Oral Hygiene MH - Diet PMC - PMC13715219 OTO - NOTNLM OT - BMI OT - Defs OT - Deft OT - Early childhood caries OT - Oral health-related quality of life COIS- Declarations. Ethics approval and consent to participate: The ethical clearance certificate (ERC/FDS/UOP/I/2021/45) was obtained from the Ethical Review Committee, Faculty of Dental Sciences, University of Peradeniya, on 12th October 2021. According to that, Information regarding the research was conveyed to parents or guardians by a typed information sheet in a manner and a language suitable to the individual's level of understanding. The participants were given adequate opportunity to ask questions, and they were answered honestly and completely. Parents or guardians were made aware that they were free to withdraw their consent at any time without trepidation of consequences. Finally, the consent was obtained as a signature on a consent form that explicitly stated what was being consented to. Participants were not subjected to coercion, inducement, undue influence, or deception at any cost. Consent for publication: Parents or guardians were informed that these data would be published in journal articles, and consent was obtained as a signature on a consent form. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/07/23 CRDT- 2026/10/28 00:48 PHST- 2026/03/05 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:48 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1186/s41043-026-01407-6 [pii] AID - 1407 [pii] AID - 10.1186/s41043-026-01407-6 [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jul 23;45(1):238. doi: 10.1186/s41043-026-01407-6. PMID- 42947253 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261028 LR - 20261028 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Oct 27 TI - Cross-group and longitudinal measurement invariance of the Child Eating Behavior Questionnaire-24G in middle childhood. LID - 10.1186/s40337-026-01806-4 [doi] LID - 252 AB - BACKGROUND: Childhood eating behaviors are most commonly assessed using parent-report questionnaires. To validly compare means across different groups or over time, equivalent item functioning is an important prerequisite. This study investigates the measurement invariance of a short German version of the Child Eating Behavior Questionnaire, the CEBQ-24G, across child sex, age, weight status, family socio-economic status, and parental weight status, as well as across three measurement occasions spanning three years in middle childhood. METHODS: Analyses were conducted using a large community sample (N = 1,657) recruited from primary schools in Brandenburg, Germany. Measurement invariance was tested and latent group means were compared using Multigroup Confirmatory Factor Analysis (CFA). RESULTS: The CEBQ-24G is measurement invariant on the residual level across all groups and measurement occasions, i.e., assessed differences in eating behaviors between these groups and measurement occasions are derived from actual differences in latent constructs and not a result of measurement bias-thus allowing valid comparisons of latent means across child sex, age, weight status, parental weight status, and family socio-economic status. We found significant differences in all group comparisons (except between age groups), although the eating behavior scales in which the differences in mean scores occurred varied depending on which groups were compared. CONCLUSIONS: Our findings suggest that the CEBQ-24G has good psychometric properties in all groups and is suitable for research into eating behaviors in middle childhood in diverse populations. CI - (c) 2026. The Author(s). FAU - Ruden, Joyce C AU - Ruden JC AUID- ORCID: 0009-0009-2462-8031 AD - Department of Psychology, Counseling Psychology, University of Potsdam, Potsdam, Germany. FAU - Warschburger, Petra AU - Warschburger P AUID- ORCID: 0000-0001-7979-7451 AD - Department of Psychology, Counseling Psychology, University of Potsdam, Potsdam, Germany. petra.warschburger@uni-potsdam.de. LA - eng PT - Journal Article DEP - 20261027 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13711984 OAB - The 24-item German adaptation of the Child Eating Behavior Questionnaire (CEBQ-24G) is a tool to assess a child's eating behaviors via parent report. This study examined whether the questionnaire is understood in the same way across different groups and multiple measurements. Such measurement equivalence is required in order to make valid comparisons between eating behaviors across groups and over time. Using a sample of 1,657 children from primary schools in Brandenburg, Germany, we confirmed the questionnaire's measurement equivalence across child sex, age, weight status, family socio-economic status, and parental weight status, as well as across time in middle childhood. This enabled us to compare eating behaviors across these groups. We found differences in eating behaviors based on children's sex, weight status group, their parent's weight status group, and their family's socio-economic status, but not age. Overall, this study demonstrates that the CEBQ-24 validly assesses children's eating behavior in diverse samples and over time. OABL- eng OTO - NOTNLM OT - Child Eating Behavior Questionnaire OT - Childhood OT - Eating behavior OT - Group differences OT - Measurement invariance OT - Multigroup CFA OT - Parent report COIS- Declarations. Ethics approval and consent to participate: Approval was obtained from the ethics committee of the University of Potsdam, Germany (reference numbers 28-33/2011, 3-10/2012, 21/2012, 32/2014, 18/2020, 10/2022, and 37/2022). The procedures used in this study adhere to the tenets of the Declaration of Helsinki. Informed consent was obtained from each participant. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/10/27 CRDT- 2026/10/28 00:47 PHST- 2026/06/11 00:00 [received] PHST- 2026/10/18 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:47 [entrez] PHST- 2026/10/27 00:00 [pmc-release] AID - 10.1186/s40337-026-01806-4 [pii] AID - 1806 [pii] AID - 10.1186/s40337-026-01806-4 [doi] PST - epublish SO - J Eat Disord. 2026 Oct 27;14(1):252. doi: 10.1186/s40337-026-01806-4. PMID- 42947242 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Oct 22 TI - Patterns of attentional and recognition-memory processing of emotional information among Chinese middle school students with different exercise volumes. LID - 10.1186/s40359-026-05840-4 [doi] LID - 1554 AB - BACKGROUND: Physical exercise is closely associated with adolescent mental health, yet emotional information processing among adolescents with different exercise volumes remains insufficiently understood. This study examined attentional and recognition-memory processing of positive and negative emotional information among middle school students with different exercise volumes. METHODS: Using convenience sampling, 300 copies of a modified 3-month-recall version of the Physical Activity Rating Scale-3 (PARS-3) were distributed at a middle school, yielding 291 valid questionnaires. In a cross-sectional extreme-group design, 60 students (30 per group) were recruited from the extreme ends of the high- and low-exercise-volume categories to complete the behavioral experiment. Task 1 used a dot-probe task to examine reaction time, probe congruency, and vigilance and disengagement/avoidance indices in response to positive and negative emotional pictures. Task 2 used a learning-recognition task to examine recognition accuracy, recognition sensitivity (d'), and response criterion (c) for positive and negative faces. RESULTS: In the dot-probe task, the Group x Valence interaction was significant, and the low-exercise-volume group responded faster to negative than to positive pictures. The Group x Valence interaction for the attentional disengagement/avoidance index was also significant, with the low-exercise-volume group showing a larger positive-picture disengagement/avoidance index, a pattern consistent with greater difficulty disengaging attention from positive pictures. In the learning-recognition task, Group x Valence interactions were significant for both d' and recognition accuracy, whereas the corresponding interaction for c was not significant. The low-exercise-volume group showed lower d' for positive than for negative faces, and its d' for positive faces was lower than that of the high-exercise-volume group; the accuracy analysis showed a corresponding within-group valence difference. CONCLUSIONS: Middle school students with different exercise volumes showed different valence-related patterns of emotional information processing, primarily in overall reaction time, the derived disengagement/avoidance index, and recognition sensitivity. Overall, exercise volume was associated with emotional information processing in adolescents. Because the behavioral sample was recruited from the extreme ends of the screening distribution, the observed group differences and effect sizes characterize selected extreme-group contrasts; they are not population-level estimates for typical high- versus low-exercise-volume adolescents. Longitudinal and experimental studies are needed to examine causal relationships. CI - (c) 2026. The Author(s). FAU - Chen, Kaiyu AU - Chen K AD - Wuxi Vocational Institute of Commerce, Wuxi, China. AD - School of Education Science, Jiangsu Normal University, Xuzhou, China. FAU - Wang, Pengfei AU - Wang P AUID- ORCID: 0000-0003-2380-5541 AD - School of Education Science, Jiangsu Normal University, Xuzhou, China. wppsy1525@gmail.com. AD - School of Psychology, Nanjing Normal University, Nanjing, 210097, China. wppsy1525@gmail.com. LA - eng GR - 2024KJD010/Science and Technology Innovation Support Program for Young Scholars in Shandong Universities/ PT - Journal Article DEP - 20261022 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 RN - Chinese people SB - IM MH - Humans MH - *Attention/physiology MH - *Exercise/psychology MH - Adolescent MH - Male MH - *Emotions/physiology MH - Female MH - *Recognition, Psychology/physiology MH - China MH - Students/psychology MH - Reaction Time MH - Cross-Sectional Studies MH - Child MH - East Asian People PMC - PMC13715273 OTO - NOTNLM OT - Attentional processing OT - Emotional information processing OT - Exercise volume OT - Learning-recognition OT - Middle school students COIS- Declarations. Ethics approval and consent to participate: All procedures were conducted in accordance with the Declaration of Helsinki and relevant ethical principles and institutional guidelines for research involving human participants. The study protocol was reviewed and approved by the Biomedical Research Ethics Committee of Nanjing Normal University (approval No. NNU202503051). All participants were minors. Before data collection, each student provided written assent to participate, and written informed consent was obtained from a parent or legal guardian. Students took part only after both the student assent and parental or legal-guardian consent procedures had been completed. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/10/22 CRDT- 2026/10/28 00:46 PHST- 2026/06/01 00:00 [received] PHST- 2026/10/16 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:46 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - 10.1186/s40359-026-05840-4 [pii] AID - 5840 [pii] AID - 10.1186/s40359-026-05840-4 [doi] PST - epublish SO - BMC Psychol. 2026 Oct 22;14(1):1554. doi: 10.1186/s40359-026-05840-4. PMID- 42947061 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 31 TI - Effects of school-based nutrition education on self-efficacy, attitudes, food behaviors, and health in children. LID - 10.1186/s12887-026-07412-2 [doi] LID - 1075 AB - BACKGROUND AND AIM: School-based nutrition education programs are commonly used to promote healthy eating behaviors among children; however, their effectiveness may vary according to developmental stage. The present study aimed to evaluate the effects of a school-based nutrition education program on children's dietary self-efficacy (CDSS), dietary attitudes (DAS), food behaviors (FBS), and children self-rated health scale (CSHC). MATERIALS AND METHODS: This study employed a pre-post nutrition intervention design and including 1418 primary and secondary school students from different grade levels. CDSS, DAS, FBS, and CSHC were assessed before and after the nutrition education using validated self-report scales. Changes following the intervention were statistically examined and differences according to grade level and gender were analyzed. RESULTS: Following the nutrition education program, a significant improvement was observed in child nutrition self-efficacy. In contrast, no significant overall changes were found in dietary attitudes, food behaviors, or self-rated health perception. Dietary attitudes and food behaviors differed significantly by grade level both before and after the intervention, with older children's dietary self-efficacy and food behaviors were more evident in certain lower grade levels. No significant differences were observed between girls and boys with respect to dietary attitudes or food behaviors. CONCLUSIONS: The findings suggest that while school-based nutrition education can enhance dietary self-efficacy, short-term educational interventions alone may be insufficient to produce measurable changes in children's eating behaviors. Developmentally tailored, multi-component interventions that incorporate family involvement and environmental factors may be necessary to support sustained improvements in dietary behaviors, particularly among older school-age children. CI - (c) 2026. The Author(s). FAU - Terzi, Merve AU - Terzi M AUID- ORCID: 0000-0003-3397-9692 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul, Turkey. merve.terzi@yeniyuzyil.edu.tr. FAU - Ergan, Kubra AU - Ergan K AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul, Turkey. AD - Department of Nutrition and Dietetics, Istinye University, Graduate School, Istanbul, Turkiye. FAU - Demirkesen-Bicak, Hilal AU - Demirkesen-Bicak H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260731 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Male MH - Female MH - *Self Efficacy MH - Child MH - *Feeding Behavior/psychology MH - *Health Education/methods MH - *School Health Services MH - *Health Knowledge, Attitudes, Practice PMC - PMC13715218 OTO - NOTNLM OT - Dietary attitudes OT - Dietary self-efficacy OT - Eating behaviors in children OT - Health-related quality of life OT - School-based nutrition intervention COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was obtained from the Istanbul Yeni Yuzyil University Ethics Committee (Approval Number: 2025/03-1511). All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the Declaration of Helsinki and its later amendments. Written informed consent was obtained from the parents/legal guardians of all participants prior to participation in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/07/31 CRDT- 2026/10/28 00:37 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:37 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.1186/s12887-026-07412-2 [pii] AID - 7412 [pii] AID - 10.1186/s12887-026-07412-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 31;26(1):1075. doi: 10.1186/s12887-026-07412-2. PMID- 42946529 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1557-8224 (Electronic) IS - 1089-3261 (Linking) VI - 30 IP - 4 DP - 2026 Nov TI - Metabolic Dysfunction-Associated Steatotic Liver Disease in Children. PG - 987-1007 LID - S1089-3261(26)00071-1 [pii] LID - 10.1016/j.cld.2026.07.009 [doi] AB - Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease among children and adolescents worldwide. Pediatric MASLD is associated with significant morbidity during childhood, including progressive liver fibrosis and incident diabetes, and significantly increases risk of premature mortality in early adulthood. In comparison to MASLD in adults, youth-onset MASLD exhibits distinct histologic patterns, lacks well-validated noninvasive tests for risk stratification and approved pharmacotherapy, and may carry higher risk of long-term liver-related mortality. Critical areas of unmet need include improving rates of recommended screening, development of pediatric-specific risk stratification tools and developing more effective prevention and treatment strategies. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Yodoshi, Toshifumi AU - Yodoshi T AD - Division of Gastroenterology, Hepatology, Pancreatology, and Nutrition, Department of Pediatrics, Stead Family Children's Hospital, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. FAU - Xanthakos, Stavra AU - Xanthakos S AD - Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: stavra.xanthakos@cchmc.org. LA - eng PT - Journal Article PT - Review DEP - 20260904 PL - United States TA - Clin Liver Dis JT - Clinics in liver disease JID - 9710002 SB - IM MH - Humans MH - Child MH - *Fatty Liver/diagnosis/therapy/epidemiology/etiology MH - Risk Factors MH - Adolescent MH - Liver Cirrhosis/etiology/epidemiology MH - *Non-alcoholic Fatty Liver Disease/diagnosis/therapy/epidemiology MH - Obesity/epidemiology/complications MH - Diabetes Mellitus, Type 2/epidemiology/complications OTO - NOTNLM OT - Fibrosis OT - MASH OT - MASLD OT - Mortality OT - Obesity OT - Type 2 diabetes COIS- Disclosure Dr S. Xanthakos has served as a scientific advisor to Novo Nordisk and Madrigal. Dr T. Yodoshi has nothing to disclose. EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:29 CRDT- 2026/10/27 21:54 PHST- 2026/10/27 23:29 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 21:54 [entrez] AID - S1089-3261(26)00071-1 [pii] AID - 10.1016/j.cld.2026.07.009 [doi] PST - ppublish SO - Clin Liver Dis. 2026 Nov;30(4):987-1007. doi: 10.1016/j.cld.2026.07.009. Epub 2026 Sep 4. PMID- 42945754 OWN - NLM STAT- Publisher LR - 20261027 IS - 1873-5487 (Electronic) IS - 0188-4409 (Linking) VI - 58 IP - 1 DP - 2026 Oct 27 TI - Validation of the Healthy Complementary Feeding Practices Index: A Novel Approach for Assessing Infant Feeding in Mexico. PG - 103535 LID - S0188-4409(26)00157-8 [pii] LID - 10.1016/j.arcmed.2026.103535 [doi] AB - OBJECTIVE: To develop and validate the Healthy Complementary Feeding Practices Index (HCFPI), a novel tool designed to assess adherence to Mexico's national dietary guidelines and inform the design of interventions to prevent malnutrition in infants aged 6-24 months. METHODS: The HCFPI was constructed using a literature-based selection of components, indicators, and scoring criteria. Content validity was evaluated using the Delphi method with experts. Internal consistency (Cronbach's alpha) and concurrent validity with dietary intake were examined in a cross-sectional sample from a Mexican birth cohort at 6, 12, and 24 months. RESULTS: The HCFPI comprises 13 components and 15 items that reflect key CF dimensions, and it achieved "acceptable" expert consensus during content validation. The index demonstrated "acceptable" internal consistency (alpha = 0.70) and meaningful correlations with optimal Complementary Feeding (CF) practices, such as breastfeeding, the timely introduction of solids, and the avoidance of both unhealthy salty foods and follow-up formulas. Furthermore, higher HCFPI scores were associated with better dietary quality, including higher fiber intake, greater protein and vitamin B12 adequacy, and lower added sugar intake. CONCLUSION: The HCFPI is a valid, reliable, and practical tool for evaluating adherence to CF recommendations and dietary quality in young children. Its framework offers a model that could be adapted to create similar indices in other countries using evidence-based national dietary guidelines. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Tercero-Gomez, Francia AU - Tercero-Gomez F AD - National Institute of Public Health, Center for Nutrition and Health Research. FAU - Ramirez-Silva, Ivonne AU - Ramirez-Silva I AD - National Institute of Public Health, Center for Nutrition and Health Research. Electronic address: ciarmir@insp.mx. FAU - Rivera, Juan A AU - Rivera JA AD - National Institute of Public Health, Center for population Health Research. FAU - Fuentes-Garcia, Ruth AU - Fuentes-Garcia R AD - Department of Mathematics, Faculty of Science, National Autonomus of Mexico, Mexico City, Mexico. FAU - Perez-Escamilla, Rafael AU - Perez-Escamilla R AD - Yale School of Public Health. Yale University, New Haven, CT. USA. FAU - Olvera-Mayorga, Gabriela AU - Olvera-Mayorga G AD - National Institute of Public Health, Center for Nutrition and Health Research; Nutrition Academic Area, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Mexico. FAU - Barragan-Vazquez, Sofia AU - Barragan-Vazquez S AD - National Institute of Public Health, Center for Nutrition and Health Research; Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Woodhouse, Leeds, UK. LA - eng PT - Journal Article DEP - 20261027 PL - United States TA - Arch Med Res JT - Archives of medical research JID - 9312706 SB - IM OTO - NOTNLM OT - Complementary feeding OT - Diet quality OT - Index OT - Infant feeding practices OT - Validation EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:28 CRDT- 2026/10/27 19:07 PHST- 2025/10/02 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/27 23:28 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 19:07 [entrez] AID - S0188-4409(26)00157-8 [pii] AID - 10.1016/j.arcmed.2026.103535 [doi] PST - aheadofprint SO - Arch Med Res. 2026 Oct 27;58(1):103535. doi: 10.1016/j.arcmed.2026.103535. PMID- 42945744 OWN - NLM STAT- Publisher LR - 20261027 IS - 1879-0267 (Electronic) IS - 0020-1383 (Linking) VI - 57 IP - 12 DP - 2026 Oct 24 TI - The downside of the pull-up: A 10-year national analysis of emergency department visits, 2015-2024. PG - 113804 LID - S0020-1383(26)00791-6 [pii] LID - 10.1016/j.injury.2026.113804 [doi] AB - BACKGROUND: To characterize the epidemiology and clinical patterns of injuries related to pull-up and chin-up bars in a nationally representative emergency department (ED) dataset. METHODS: Retrospective cross-sectional analysis of the U.S. Consumer Product Safety Commission National Electronic Injury Surveillance System from January 1, 2015, to December 31, 2024. Cases were identified using product code 3277 with narrative filters for "pull-up," "chin-up," and "doorway bar," excluding barbells and playground equipment. NEISS sampling weights produced national estimates. Annual totals with 95 % confidence intervals were calculated and reported. Injury characteristics were summarized by age group, body region, diagnosis, location, disposition, and a narrative-derived mechanism category (fall, struck by bar, slip or detachment, other). RESULTS: An estimated 40,987 ED visits were attributed to pull-up bar injuries, averaging about 4000 per year, with a peak in 2024 (5421; 95 % CI, 5315-5527). Patients were predominantly male (66.1 %) with a bimodal age distribution centered on children 5-14 years and adults 18-34 years. Craniofacial trauma predominated, with head and face together comprising nearly one-half of presentations, followed by upper-extremity involvement, including shoulder, wrist, and forearm. Laceration, internal head injury, and fracture were the leading diagnoses, with sprain or strain and contusion also frequent. Most incidents occurred in the home, and 93.8 % of patients were treated and released. Falls were the most common mechanism, followed by struck-by events and a subset explicitly involving bar slip or detachment. CONCLUSIONS: Pull-up bar injuries constitute a consistent national burden of craniofacial and upper-extremity trauma concentrated in youth and young adults, largely managed nonoperatively in acute care settings. Improved recognition of exercise-associated injury mechanisms may assist diagnostic accuracy and reduce the burden on emergency and orthopedic services. CI - Copyright (c) 2026 British Trauma Society. Published by Elsevier Ltd. All rights reserved. FAU - Shabbir, Roban AU - Shabbir R AD - Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Electronic address: roban@temple.edu. FAU - Layton, Brendan AU - Layton B AD - Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Electronic address: tuj67333@temple.edu. FAU - Kang, Zion AU - Kang Z AD - Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Electronic address: tus57015@temple.edu. FAU - Kim, Brandon AU - Kim B AD - Department of Orthopedic Surgery, Temple University Hospital, Philadelphia, PA, USA. Electronic address: Brandon.Kim@tuhs.temple.edu. FAU - Rehman, Saqib AU - Rehman S AD - Department of Orthopedic Surgery, Temple University Hospital, Philadelphia, PA, USA. Electronic address: Saqib.Rehman@tuhs.temple.edu. FAU - Galos, David K AU - Galos DK AD - Department of Orthopedic Surgery, Temple University Hospital, Philadelphia, PA, USA. Electronic address: David.Galos@tuhs.temple.edu. LA - eng PT - Journal Article DEP - 20261024 PL - Netherlands TA - Injury JT - Injury JID - 0226040 SB - IM OTO - NOTNLM OT - Craniofacial trauma OT - Emergency department surveillance OT - Exercise-related injuries OT - Home fitness equipment COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:28 CRDT- 2026/10/27 19:06 PHST- 2025/11/18 00:00 [received] PHST- 2026/10/11 00:00 [accepted] PHST- 2026/10/27 23:28 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 19:06 [entrez] AID - S0020-1383(26)00791-6 [pii] AID - 10.1016/j.injury.2026.113804 [doi] PST - aheadofprint SO - Injury. 2026 Oct 24;57(12):113804. doi: 10.1016/j.injury.2026.113804. PMID- 42945536 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1665-1731 (Electronic) IS - 1405-9940 (Print) IS - 1665-1731 (Linking) VI - 96 IP - Supl 4 DP - 2026 TI - Inter-American consensus on hypertrophic cardiomyopathy. PG - 1-60 LID - 10.24875/ACM.26000187 [doi] AB - BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and poses major diagnostic and therapeutic challenges in Latin America, owing to heterogeneity in resource availability, access to advanced technologies, and the organization of health systems. OBJECTIVES: To develop the first Inter-American Consensus on HCM, in order to standardize the care of these patients tailored to the regional context. METHODS: The Inter-American Society of Cardiology (SIAC) convened a committee of experts from different countries across the Americas. A systematic review of the evidence was performed, followed by the development of recommendations, which were validated using a formal Delphi methodology; consensus was defined as agreement among more than 80% of participants. RESULTS: The consensus provides a comprehensive approach to the evaluation and management of HCM. It covers epidemiology, pathophysiology, multimodality diagnostic tools, genetics and family counseling, phenocopies, pharmacological and invasive treatment, associated complications, sudden cardiac death risk assessment, special populations (pediatric and pregnant patients), physical exercise, and follow-up strategies. In addition, it includes specific recommendations aimed at facilitating the implementation of these across Latin America. CONCLUSIONS: The Inter-American Consensus on HCM provides recommendations for the diagnosis and treatment of this condition. It integrates the best available evidence with regional clinical experience and takes into account the epidemiological, economic, and healthcare characteristics of the region. It constitutes a reference framework for standardizing the care of patients with HCM and their families throughout Latin America. CI - Copyright: (c) 2026 Permanyer. FAU - Parodi, Josefina B AU - Parodi JB AD - Departamento de Cardiologia, Sanatorio Anchorena San Martin, San Martin, Buenos Aires, Argentina. FAU - Scatularo, Cristhian E AU - Scatularo CE AD - Departamento de Cardiologia, Sanatorio de la Trinidad de Palermo, Buenos Aires, Argentina. FAU - Berrios-Barcenas, Enrique A AU - Berrios-Barcenas EA AD - Departamento de Consulta Externa, Instituto Nacional de Cardiologia Ignacio Chavez, Ciudad de Mexico, Mexico. FAU - Leon, Juan D Lopez-Ponce de AU - Leon JDL AD - Departamento de Cardiologia, Fundacion Valle del Lili, Cali, Colombia. FAU - Arenaza, Diego Perez de AU - Arenaza DP AD - Servicio de Cardiologia, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. FAU - Gomez, Luis E AU - Gomez LE AD - Division de Cardiologia, Hospital General de Agudos Juan A. Fernandez, Buenos Aires, Argentina. FAU - Costabel, Juan P AU - Costabel JP AD - Unidad Coronaria, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina. FAU - Fernandes, Fabio AU - Fernandes F AD - Grupo de Cardiomiopatias, Instituto do Coracao (InCor), Sao Paulo, Brasil. FAU - Saldarriaga, Clara AU - Saldarriaga C AD - Clinica CardioVID, Universidad Pontificia Bolivariana, Medellin, Colombia. FAU - Rossel, Victor AU - Rossel V AD - Departamento de Cardiologia, Hospital del Salvador, Santiago de Chile, Chile. FAU - Rochitte, Carlos E AU - Rochitte CE AD - Instituto do Coracao (InCor), Sao Paulo, Brasil. FAU - Stein, Ricardo AU - Stein R AD - Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brasil. FAU - Concepcion-Chacon, Roberto AU - Concepcion-Chacon R AD - Unidad de Insuficiencia Cardiaca, Hospital DIPRECA, Santiago de Chile, Chile. FAU - Parma-Romanelli, Gabriel AU - Parma-Romanelli G AD - Departamento de Cardiologia, Hospital Evangelico, Montevideo, Uruguay. FAU - Gonzalez-Carta, Karina AU - Gonzalez-Carta K AD - Departamento de Cirugia Ortopedica, Mayo Clinic, Rochester, Minnesota, EE.UU. FAU - Blanco-Sobrino, Susana AU - Blanco-Sobrino S AD - Servicio de Cardiologia, Instituto de Clinicas y Urologia Tamanaco, Caracas, Venezuela. FAU - Sierra-Lara-Martinez, Daniel AU - Sierra-Lara-Martinez D AD - Urgencias y Unidad de Cuidados Criticos Coronarios, Instituto Nacional de Cardiologia Ignacio Chavez, Ciudad de Mexico, Mexico. FAU - Leoni, Franco AU - Leoni F AD - Medica Uruguaya (MUCAM), Montevideo, Uruguay. FAU - Jalil, Jorge AU - Jalil J AD - Division de Enfermedades Cardiovasculares, Pontificia Universidad Catolica de Chile, Santiago, Chile. FAU - Delgado, Yamiris AU - Delgado Y AD - Servicio de Cardiologia, Centro Medico Real, Santo Domingo, Republica Dominicana. FAU - Chango, Diego X AU - Chango DX AD - Servicio de Cardiologia, Clinica Santa Ana, Cuenca, Ecuador. FAU - Posada-Martinez, Liliana AU - Posada-Martinez L AD - Departamento de Ecocardiografia, Instituto Nacional de Cardiologia Ignacio Chavez, Ciudad de Mexico, Mexico. FAU - Rodriguez-Amaguay, Landy AU - Rodriguez-Amaguay L AD - Servicio de Imagenes Cardiovasculares, Centro Ecuatoriano de Diagnostico Cardiovascular, Guayaquil, Ecuador. FAU - Guaman-Valdivieso, Carlos AU - Guaman-Valdivieso C AD - Novaclinica Santa Cecilia, Quito, Ecuador. FAU - Rendon-Giraldo, Jairo A AU - Rendon-Giraldo JA AD - Departamento de Cardiologia, Hospital San Vicente Fundacion, Medellin, Colombia. FAU - Arevalos, Victor AU - Arevalos V AD - Departamento de Cardiologia, Hospital Central del Instituto de Prevision Social, Asuncion, Paraguay. FAU - Marquez, Ingrid AU - Marquez I AD - Departamento de Cardiologia, Hospital del Este Dr. Domingo Luciani, Caracas, Venezuela. FAU - Cantora, Florencia B AU - Cantora FB AD - Servicio de Cardiologia, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. FAU - Estofan, Mariano D AU - Estofan MD AD - Sanatorio 9 de Julio, San Miguel de Tucuman, Argentina. FAU - Cardenas-Reyes, Ivonne AU - Cardenas-Reyes I AD - Cardiologia Pediatrica, Health in Code, Valencia, Espana. FAU - Brogger, Noel AU - Brogger N AD - Cardiologia Pediatrica, Health in Code, Valencia, Espana. FAU - Bejarano, Maria C AU - Bejarano MC AD - Centro de Investigaciones Clinicas (CIC), Fundacion Valle del Lili, Cali, Colombia. FAU - Lara-Teran, Joffre AU - Lara-Teran J AD - Servicio de Cardiologia, Hospital Juan Tanca Marengo, Guayaquil, Ecuador. FAU - Vaca-Valverde, Ignacio AU - Vaca-Valverde I AD - Cardiovida, Santa Cruz de la Sierra, Bolivia. FAU - Olivares-Asencio, Carlos AU - Olivares-Asencio C AD - Departamento de Cardiologia, Hospital Hernan Henriquez Aravena, Temuco, Chile. FAU - Cura-Hochbaum, Leandro AU - Cura-Hochbaum L AD - Cardiocentro, Asociacion Espanola, Montevideo, Uruguay. FAU - Morejon-Barragan, Paola A AU - Morejon-Barragan PA AD - Clinica Guayaquil, Guayaquil, Ecuador. FAU - Fava, Agostina M AU - Fava AM AD - Cleveland Clinic, Cleveland, Ohio, EE.UU. FAU - Miranda-Arboleda, Andres F AU - Miranda-Arboleda AF AD - Instituto de Cardiologia, Universidad de Ottawa, Ottawa, Canada. FAU - Marquez-Murillo, Manlio F AU - Marquez-Murillo MF AD - Departamento de Cardiologia, Centro Medico ABC, Ciudad de Mexico, Mexico. FAU - Karabut, Eric AU - Karabut E AD - Departamento de Cardiologia, Hospital Punta Pacifica, Ciudad de Panama, Panama. FAU - Berni-Betancourt, Ana C AU - Berni-Betancourt AC AD - Departamento de Cardiologia, Hospital Angeles Pedregal, Ciudad de Mexico, Mexico. FAU - Alba, Ana C AU - Alba AC AD - Peter Munk Cardiac Centre, University Health Network, Toronto, Canada. FAU - Rodriguez-Gonzalez, Maria J AU - Rodriguez-Gonzalez MJ AD - Fundacion Cardioinfantil, Bogota, Colombia. FAU - Saenz-Tejeira, Maria M AU - Saenz-Tejeira MM AD - Servicio de Cardiologia Pediatrica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. FAU - Oca, Katihurca Almonte-Montes de AU - Oca KA AD - Asociacion Instituto Dominicano de Cardiologia, Santo Domingo, Republica Dominicana. FAU - Cueto, Rosa N AU - Cueto RN AD - Departamento de Cardiologia, Hospital Regional Dr. Antonio Musa, San Pedro de Macoris, Republica Dominicana. FAU - Rodriguez-Israel, Melissa AU - Rodriguez-Israel M AD - Departamento de Cardiologia, Hospital San Vicente de Paul, Heredia, Costa Rica. FAU - Torterolo-Herrera, Alicia G AU - Torterolo-Herrera AG AD - Departamento de Cardiologia, Hospital de Clinicas, Montevideo, Uruguay. FAU - Villacreses, Vicente AU - Villacreses V AD - Departamento de Cardiologia, Manahospital, Portoviejo, Ecuador. FAU - Restrepo, Gustavo AU - Restrepo G AD - Clinica ANUA Las Americas, Medellin, Colombia. FAU - Sosa-Liprandi, Maria I AU - Sosa-Liprandi MI AD - Departamento de Cardiologia, Sanatorio Guemes, Buenos Aires, Argentina. FAU - Cingolani, Eugenio AU - Cingolani E AD - Departamento de Cardiologia, Centro Medico Cedars-Sinai, Universidad de California, Los Angeles, California, EE.UU. FAU - Baratta, Sergio AU - Baratta S AD - Servicio de Cardiologia, Hospital Universitario Austral, Buenos Aires, Argentina. FAU - Lopez-Santi, Ricardo AU - Lopez-Santi R AD - Departamento de Cardiologia, Hospital Italiano de La Plata, La Plata, Argentina. FAU - Munera-Echeverri, Ana AU - Munera-Echeverri A AD - Departamento de Cardiologia, Clinica Rosario Tesoro-Cardioestudio, Medellin, Colombia. FAU - Baranchuk, Adrian AU - Baranchuk A AD - Facultad de Medicina, Universidad Abierta Interamericana (UAI), Buenos Aires, Argentina. LA - eng PT - Consensus Statement PT - Journal Article PT - Systematic Review TT - Consenso interamericano de miocardiopatia hipertrofica. PL - Mexico TA - Arch Cardiol Mex JT - Archivos de cardiologia de Mexico JID - 101126728 SB - IM MH - Humans MH - *Cardiomyopathy, Hypertrophic/therapy/diagnosis/physiopathology/epidemiology MH - Latin America PMC - PMC13713040 OTO - NOTNLM OT - America Latina OT - Cardiac myosin inhibitors OT - Consenso OT - Consensus OT - Genetic testing OT - Hypertrophic cardiomyopathy OT - Inhibidores de la miosina cardiaca OT - Latin America OT - Miocardiopatia hipertrofica OT - Muerte subita cardiaca OT - Pruebas geneticas OT - Sudden cardiac death COIS- Los autores declaran no tener conflictos de intereses relacionados con el contenido de este manuscrito. EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:29 PMCR- 2026/01/01 CRDT- 2026/10/27 17:13 PHST- 2026/10/27 23:29 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 17:13 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - j96/Supl 4/1 [pii] AID - 12352AMEX261-ACM-96-1 [pii] AID - 10.24875/ACM.26000187 [doi] PST - ppublish SO - Arch Cardiol Mex. 2026;96(Supl 4):1-60. doi: 10.24875/ACM.26000187. PMID- 42945193 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Bridging the gap: Implementing BRIDGES (Brussels Resilience and Inclusion for Depression - Guidance, Exercise and Support) to shape adolescent outpatient mental health care. A pilot randomized controlled study protocol. PG - e0360292 LID - 10.1371/journal.pone.0360292 [doi] LID - e0360292 AB - INTRODUCTION: Physical activity interventions for adolescents with depression often show limited effectiveness due to insufficient developmental tailoring, limited autonomy support, and poor contextual feasibility. BRIDGES (Brussels Resilience and Inclusion for Depression - Guidance, Exercise, and Support) is a theory-informed and co-designed physical activity intervention integrating the COM-B model, self-determination theory and motivational interviewing to support autonomous and competence-enhancing engagement. This pilot randomized controlled trial uses a hybrid type 2 implementation-effectiveness design to examine feasibility, acceptability, implementation processes and obtain preliminary estimates of clinical effectiveness to inform a future larger-scale trial. METHODS AND ANALYSIS: Sixty physically inactive adolescents aged 12-19 years with depression will be recruited from an outpatient mental health service in Brussels, Belgium. Participants will be randomized in waves using covariate-adaptive minimization with a biased-coin component (p=0.85), balancing baseline depression severity, physical activity level, gender and age. The intervention consists of 18 individualized physiotherapist-led counselling sessions delivered over 12 weeks, including structured support to facilitate transition to community-based physical activity. Primary feasibility, acceptability, implementation outcomes will be assessed using quantitative measures and semi-structured interviews with adolescents, caregivers and community partners, guided by the Practical, Robust Implementation and Sustainability Model (PRISM) and the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework. Preliminary effectiveness outcomes are changes in physical activity measured using the Physical Activity Vital Sign (PAVS) and depressive symptoms measured using the Patient Health Questionnaire-9 modified for Adolescents (PHQ-A). Preliminary effectiveness will be analysed using linear mixed-effects models following an intention-to-treat approach to estimate cluster-level parameters for a future fully powered Hybrid Type 2 trial. Secondary outcomes include social support, exercise self-efficacy, cardiorespiratory fitness and waist-to-height ratio. Qualitative data will be analysed using the Qualitative Analysis Guide of Leuven. TRIAL REGISTRATION: ClinicalTrials.gov NCT07422909. CI - Copyright: (c) 2026 Philippot et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Philippot, Arnaud AU - Philippot A AUID- ORCID: 0000-0002-0706-4491 AD - Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium. AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. AD - UCLouvain, Louvain-la-Neuve, Institute of Neuroscience, Belgium. FAU - Ibanez, Irene AU - Ibanez I AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. FAU - Coppens, Marine AU - Coppens M AD - UCLouvain, Louvain-la-Neuve, Institute of Neuroscience, Belgium. FAU - Eeckhout, Coralie AU - Eeckhout C AD - UCLouvain, Louvain-la-Neuve, Institute of Neuroscience, Belgium. FAU - Cescutti, Catherine AU - Cescutti C AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. FAU - Beine, Alexandre AU - Beine A AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. FAU - Meers, Esther AU - Meers E AUID- ORCID: 0009-0004-0626-6317 AD - Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium. FAU - Van Damme, Tine AU - Van Damme T AD - Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium. AD - University Psychiatric Center KU Leuven, Leuven, Belgium. FAU - Francaux, Marc AU - Francaux M AD - UCLouvain, Louvain-la-Neuve, Institute of Neuroscience, Belgium. FAU - Dubois, Vincent AU - Dubois V AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. AD - UCLouvain, Bruxelles-Woluwe, Institute Health and Society, Belgium. FAU - Vancampfort, Davy AU - Vancampfort D AUID- ORCID: 0000-0002-4592-8625 AD - Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium. AD - University Psychiatric Center KU Leuven, Leuven, Belgium. AD - Leuven Brain Institute, Leuven, Belgium. LA - eng SI - ClinicalTrials.gov/NCT07422909 PT - Journal Article PT - Randomized Controlled Trial DEP - 20261027 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - Pilot Projects MH - Female MH - Child MH - Male MH - *Depression/therapy/psychology MH - *Exercise MH - Young Adult MH - Outpatients/psychology MH - Belgium MH - Motivational Interviewing MH - *Ambulatory Care MH - *Mental Health Services PMC - PMC13712597 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/27 17:30 MHDA- 2026/10/27 17:31 PMCR- 2026/10/27 CRDT- 2026/10/27 13:34 PHST- 2026/09/14 00:00 [received] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/27 17:31 [medline] PHST- 2026/10/27 17:30 [pubmed] PHST- 2026/10/27 13:34 [entrez] PHST- 2026/10/27 00:00 [pmc-release] AID - PONE-D-26-34598 [pii] AID - 10.1371/journal.pone.0360292 [doi] PST - epublish SO - PLoS One. 2026 Oct 27;21(10):e0360292. doi: 10.1371/journal.pone.0360292. eCollection 2026. PMID- 42945149 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Oct 27 TI - Refining a Multicomponent Family-Based Health Education Package to Reduce Screen Time Among School-Aged Children: Qualitative Formative Evaluation With Parents and Caregivers. PG - e106521 LID - 10.2196/106521 [doi] LID - e106521 AB - BACKGROUND: Excessive screen time among school-aged children is a growing concern for child health and family routines. A previous systematic review of children aged 6 to 14 years found that excessive screen time is common in this age group, highlighting the need for feasible intervention strategies that can be implemented in daily family routines. Although many health education materials communicate the harms of excessive screen use, families often need practical support to translate risk messages into household rules, parent-child communication, alternative activities, and changes to the home environment. OBJECTIVE: This study aimed to conduct a qualitative formative evaluation of a preliminary multicomponent family-based health education package designed to support healthier screen-use practices among school-aged children, with a primary focus on reducing excessive recreational screen time and associated family routines, and to identify refinements needed before pilot implementation. METHODS: Semistructured online video interviews were conducted with 10 parents or primary caregivers of school-aged children aged 6 to 12 years from October to December 2024. The package included caregiver education for parents and grandparents, child-facing materials such as a picture book and posters, home-use reminder cues, and home-environment guidance through an online self-assessment tool that generated tailored household action suggestions. The tasks assigned to the tool were limited to these functions. Participants reviewed the package components and commented on clarity, acceptability, perceived usefulness, feasibility, fit with family routines, and suggestions for refinement. Data were analyzed using directed content analysis and thematic analysis, informed by the Theoretical Framework of Acceptability (TFA) and health communication material-evaluation dimensions. RESULTS: Four themes were generated. First, the package was generally regarded as acceptable to the participating caregivers, but comprehension did not always translate into self-reported immediate recall during interviews. Second, concrete, scenario-based messages were described as more meaningful than abstract risk information. Third, caregivers wanted action guidance rather than additional risk information. Fourth, caregivers preferred practical, age-adapted, and home-embedded tools that could be repeatedly encountered in daily routines. CONCLUSIONS: Among this selected group of caregivers, the preliminary multicomponent family-based screen-time education package was generally perceived as understandable and acceptable, but participant-informed refinements are needed before pilot implementation. The findings suggest that the package should move beyond general risk communication toward a family action toolkit that combines caregiver guidance, child-facing materials, concrete consequence chains, parent-child negotiation supports, replacement activity lists, and home environmental cues. CI - (c) Mo Zhou, Yujie Yan, Siwei Sun, Hui Yin. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Zhou, Mo AU - Zhou M AUID- ORCID: 0009-0009-1516-3631 AD - The Second People's Hospital of Shenzhen and First Affiliated Hospital of Shenzhen University, Shenzhen, China. FAU - Yan, Yujie AU - Yan Y AUID- ORCID: 0000-0002-8749-268X AD - China Japan Friendship Hospital, Beijing, China. AD - Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China. FAU - Sun, Siwei AU - Sun S AUID- ORCID: 0009-0008-4107-8177 AD - Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China. FAU - Yin, Hui AU - Yin H AUID- ORCID: 0000-0003-4013-1331 AD - School of Public Health, Peking University, No. 38 Xueyuan Road, Haidian District, Beijing, 100191, China, 86 1082805853. AD - Institute for Global Health, Peking University, Beijing, China. LA - eng PT - Journal Article DEP - 20261027 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Qualitative Research MH - *Screen Time MH - *Health Education/methods/standards MH - *Parents/education/psychology MH - *Caregivers/education/psychology MH - Adult MH - Parent-Child Relations PMC - PMC13712257 OTO - NOTNLM OT - caregivers OT - digital media OT - family-based intervention OT - formative evaluation OT - health education OT - qualitative research OT - school-aged children OT - screen time EDAT- 2026/10/27 17:30 MHDA- 2026/10/27 17:31 PMCR- 2026/10/27 CRDT- 2026/10/27 13:14 PHST- 2026/07/08 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/10/27 17:31 [medline] PHST- 2026/10/27 17:30 [pubmed] PHST- 2026/10/27 13:14 [entrez] PHST- 2026/10/27 00:00 [pmc-release] AID - v10i1e106521 [pii] AID - 106521 [pii] AID - 10.2196/106521 [doi] PST - epublish SO - JMIR Form Res. 2026 Oct 27;10:e106521. doi: 10.2196/106521. PMID- 42944973 OWN - NLM STAT- Publisher LR - 20261027 IS - 1179-1926 (Electronic) IS - 0312-5963 (Linking) DP - 2026 Oct 27 TI - Paediatric Fentanyl Population Pharmacokinetics: A Scoping Review of Published Models. LID - 10.1007/s40262-026-01706-5 [doi] AB - OBJECTIVE AND PURPOSE: Fentanyl is a highly lipophilic opioid widely used within paediatric peri-operative and intensive-care settings, yet dosing is commonly titrated empirically because of substantial pharmacokinetic variability across developmental stages and clinical contexts. Population pharmacokinetic (PopPK) models provide a quantitative framework to characterise variability, but these have not been systematically synthesised. This scoping review aimed to identify and summarise published paediatric PopPK models of fentanyl, to compare model structures and covariate effects. METHODS: We searched Embase and MEDLINE databases from database inception to 17 February 2026 for paediatric PopPK models of fentanyl. Two reviewers independently screened papers and extracted data in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. RESULTS: Fourteen paediatric PopPK models of fentanyl were identified. Infants (64%, 9/14) and patient populations spanning multiple age groups (e.g., inclusion of infants and children) (64%, 9/14) were most frequently studied. Intravenous fentanyl was modelled in all studies. Two-compartment structures predominated (79%, 11/14). Body weight was the most consistently retained covariate (79%, 11/14), while maturation functions based on postnatal or postmenstrual age were frequently required in neonatal and infant cohorts (50%, 5/10). Other covariates (e.g., obesity, concomitant CYP3A modulators, and genetic factors) were variably explored and inconsistently retained. CONCLUSION: Within the existing fentanyl literature, important evidence gaps remain, particularly beyond intravenous administration. Existing models highlight body weight and developmental maturation as principal determinants of clearance and distribution. Evidence remains limited to intravenous administration, with no model data of non-intravenous routes and under-representation of dynamic covariates and external validation. Addressing these gaps will support robust model-informed precision dosing of fentanyl in children. CI - (c) 2026. The Author(s). FAU - Hughes, Josephine J AU - Hughes JJ AUID- ORCID: 0009-0008-4715-7597 AD - School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, A15 Pharmacy and Bank Building, Science Road, Camperdown, NSW, 2006, Australia. FAU - Nam, Gi Kon AU - Nam GK AUID- ORCID: 0009-0001-5017-2869 AD - School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, A15 Pharmacy and Bank Building, Science Road, Camperdown, NSW, 2006, Australia. FAU - Stokes, Michael A AU - Stokes MA AUID- ORCID: 0009-0005-6615-4998 AD - School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, A15 Pharmacy and Bank Building, Science Road, Camperdown, NSW, 2006, Australia. AD - Kids Critical Care Research, Children's Hospital at Westmead, Westmead, NSW, Australia. FAU - Sandaradura, Indy AU - Sandaradura I AUID- ORCID: 0000-0002-9457-8262 AD - Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, NSW, Australia. AD - Faculty of Medicine and Health, Westmead Clinical School, The University of Sydney, Sydney, NSW, Australia. AD - Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Sydney, NSW, Australia. FAU - Festa, Marino S AU - Festa MS AUID- ORCID: 0000-0001-6541-7841 AD - Kids Critical Care Research, Children's Hospital at Westmead, Westmead, NSW, Australia. FAU - Stocker, Sophie L AU - Stocker SL AUID- ORCID: 0000-0002-2114-587X AD - School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, A15 Pharmacy and Bank Building, Science Road, Camperdown, NSW, 2006, Australia. sophie.stocker@sydney.edu.au. AD - Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital Sydney, Sydney, NSW, 2010, Australia. sophie.stocker@sydney.edu.au. AD - St. Vincent's Clinical Campus, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia. sophie.stocker@sydney.edu.au. LA - eng PT - Journal Article PT - Review DEP - 20261027 PL - Switzerland TA - Clin Pharmacokinet JT - Clinical pharmacokinetics JID - 7606849 SB - IM COIS- Declarations. Conflicts of interest/competing interests: Sophie Stocker is an Editorial Board member of Clinical Pharmacokinetics and was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions. No other authors declare any other conflicts of interest. Ethics approval: Not applicable. Consent to participate: Not applicable. Consent for publication: Not applicable. Availability of data and material code: Not applicable. Authors' contributions: JJH, MAS, SLS, MSF, and IS conceived the article and determined the study design. JJH, GKN, MAS, and SLS participated in article screening and collected the data. JJH drafted the manuscript and analysed the results. All authors contributed to critical review of the manuscript draft and approved the final version of the manuscript. EDAT- 2026/10/27 17:30 MHDA- 2026/10/27 17:30 CRDT- 2026/10/27 12:20 PHST- 2026/05/01 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/10/27 17:30 [medline] PHST- 2026/10/27 17:30 [pubmed] PHST- 2026/10/27 12:20 [entrez] AID - 10.1007/s40262-026-01706-5 [pii] AID - 10.1007/s40262-026-01706-5 [doi] PST - aheadofprint SO - Clin Pharmacokinet. 2026 Oct 27. doi: 10.1007/s40262-026-01706-5. PMID- 42944615 OWN - NLM STAT- Publisher LR - 20261027 IS - 1531-698X (Electronic) IS - 1040-8703 (Linking) DP - 2026 Oct 20 TI - Practical protocols and clinical experience from an academically based oral immunotherapy program. LID - 10.1097/MOP.0000000000001618 [doi] AB - PURPOSE OF REVIEW: Food allergy represents a significant public health burden with implications on quality of life and persistent risk of accidental allergic reactions. Therapeutic immunomodulation for food allergy has only recently entered clinical practice. Oral immunotherapy (OIT) has emerged as an effective approach for increasing allergen reaction thresholds; however, its implementation remains limited due to systemic factors. This review aims to describe the development, implementation, and outcomes of a standardized OIT program for immunoglobulin E (IgE)-mediated food allergy at an academic pediatric allergy institution. RECENT FINDINGS: An OIT program was developed with the objectives of improving accessibility, standardizing treatment approaches, minimizing adverse events, and allowing individualized treatment goals ranging from protection against accidental exposure to dietary liberalization. SUMMARY: OIT represents an effective, safe immunomodulatory treatment for IgE-mediated food allergy. The implementation of a standardized OIT program allowed expansion from an initial pilot program to a large clinical service involving thousands of patients. Both single-food and multifood OIT protocols were feasible and safe. Most adverse reactions were mild-moderate and gastrointestinal or cutaneous in nature. Severe reactions and eosinophilic esophagitis (EoE) were uncommon when patients were appropriately selected and monitored. Standardized protocols, careful patient selection, extensive counseling, and systematic monitoring are essential to optimize outcomes and minimize risks. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Buckey, Timothy M AU - Buckey TM AD - Division of Allergy and Immunology, Children's Hospital of Philadelphia. AD - Department of Pediatrics, Perelman School of Medicine. AD - Section of Allergy and Immunology, Division of Pulmonary, Allergy, and Critical Care Medicine. AD - Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Cianferoni, Antonella AU - Cianferoni A AD - Division of Allergy and Immunology, Children's Hospital of Philadelphia. AD - Department of Pediatrics, Perelman School of Medicine. LA - eng PT - Journal Article DEP - 20261020 PL - United States TA - Curr Opin Pediatr JT - Current opinion in pediatrics JID - 9000850 SB - IM OTO - NOTNLM OT - desensitization OT - eosinophilic esophagitis OT - food allergy OT - oral immunotherapy OT - sustained unresponsiveness EDAT- 2026/10/27 17:30 MHDA- 2026/10/27 17:30 CRDT- 2026/10/27 11:04 PHST- 2026/10/27 17:30 [medline] PHST- 2026/10/27 17:30 [pubmed] PHST- 2026/10/27 11:04 [entrez] AID - 00008480-990000000-00401 [pii] AID - 10.1097/MOP.0000000000001618 [doi] PST - aheadofprint SO - Curr Opin Pediatr. 2026 Oct 20. doi: 10.1097/MOP.0000000000001618. PMID- 42943024 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 21 TI - Maternal Overweight/Obesity and Polyunsaturated Fatty Acid Status During Pregnancy Are Associated with Offspring Body Composition at 8.5 Years: Findings from the PREOBE Study. LID - 10.3390/nu18203453 [doi] LID - 3453 AB - BACKGROUND: Maternal obesity is associated with altered polyunsaturated fatty acid (PUFA) status during pregnancy and may programme offspring adiposity, yet the contribution of specific n-3 and n-6 PUFAs across gestation and in cord blood to childhood body composition remains incompletely understood. We investigated these associations between maternal PUFA status during pregnancy and offspring obesity-related outcomes at 8.5 years. METHODS: Here, we analysed data of 172 mother-child pairs from the PREOBE cohort, grouped by maternal pregestational body mass index (BMI) as normal weight (NW, n = 84), overweight (OW, n = 47), or obese (OB, n = 41). Plasma phospholipid PUFAs were quantified at 24, 34, and 40 weeks of gestation and in cord blood. At 8.5 years, children underwent anthropometry and body-composition assessment by skinfolds and bioelectrical impedance, remaining 104 mother-child pairs with valid data. Associations analyses included ANOVA/ANCOVA adjusted by confounders variables, unadjusted bivariate Spearman rank correlations with Benjamini-Hochberg False Discovery Rate (FDR) correction, and pooled robust linear regression. RESULTS: Compared with NW mothers, OW and OB mothers showed lower alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) and higher n-6 PUFAs and n-6/n-3 ratios during pregnancy. Cord gamma-linolenic acid (GLA) was inversely associated with several adiposity measures in the NW and OW groups after FDR correction. No correlation in the OB group met the FDR threshold; the inverse cord GLA-fat-free mass index (FFMI) association was nominal only (rho = -0.52, p = 0.016, q = 0.688). In pooled regression models, cord GLA was inversely associated with BMI-for-age z-score, waist circumference z-score, waist-to-height ratio, body fat mass percentage, and fat mass index (FMI), whereas maternal GLA at 40 weeks was positively associated with body fat mass percentage and FMI. These pooled estimates do not establish group-specific effects. CONCLUSIONS: Maternal and cord-blood PUFA profiles were associated with childhood body composition, with patterns that varied descriptively by sampling time and maternal BMI group. These observational findings do not establish causality, protection, or differences between groups in the strength of association. Mechanistic and interventional research is required before individualised long-chain PUFA monitoring or supplementation can be recommended for obesity prevention. FAU - Escudero-Marin, Mireia AU - Escudero-Marin M AUID- ORCID: 0000-0001-5594-4357 AD - Department of Pediatrics, School of Medicine,University of Granada, Avda. Jesus Candel Fabregas, 18016 Granada, Spain. AD - EURISTIKOS Excellence Centre for Pediatric Research, University of Granada, Avda. del Conocimiento, 19, 18016 Granada, Spain. AD - Instituto de Investigacion Biosanitaria de Granada (Ibs-GRANADA), Avda. de Madrid, 15, Beiro, 18012 Granada, Spain. AD - Institute of Neurosciences, Biomedical Research Centre, University of Granada, Avda. del Conocimiento, 19, 18012 Granada, Spain. FAU - Azaryah, Hatim AU - Azaryah H AUID- ORCID: 0000-0001-8140-2519 AD - Department of Pediatrics, School of Medicine,University of Granada, Avda. Jesus Candel Fabregas, 18016 Granada, Spain. AD - EURISTIKOS Excellence Centre for Pediatric Research, University of Granada, Avda. del Conocimiento, 19, 18016 Granada, Spain. AD - Instituto de Investigacion Biosanitaria de Granada (Ibs-GRANADA), Avda. de Madrid, 15, Beiro, 18012 Granada, Spain. FAU - De La Garza, Andrea AU - De La Garza A AUID- ORCID: 0000-0002-5471-9585 AD - Department of Nutrition, Food Sciences and Gastronomy, XIA School of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, Spain. AD - Institut de Recerca en Nutricio i Seguretat Alimentaria UB (INSA-UB), 08921 Barcelona, Spain. FAU - Lopez-Sabater, Carmen AU - Lopez-Sabater C AUID- ORCID: 0000-0002-8670-7044 AD - Department of Nutrition, Food Sciences and Gastronomy, XIA School of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, Spain. AD - Institut de Recerca en Nutricio i Seguretat Alimentaria UB (INSA-UB), 08921 Barcelona, Spain. AD - CIBER Physiopathology of Obesity and Nutrition CIBERobn, Institute of Health Carlos III, 28029 Madrid, Spain. FAU - Bonillo-Leon, Rocio AU - Bonillo-Leon R AUID- ORCID: 0009-0005-3608-1249 AD - Department of Pediatrics, School of Medicine,University of Granada, Avda. Jesus Candel Fabregas, 18016 Granada, Spain. AD - EURISTIKOS Excellence Centre for Pediatric Research, University of Granada, Avda. del Conocimiento, 19, 18016 Granada, Spain. AD - Instituto de Investigacion Biosanitaria de Granada (Ibs-GRANADA), Avda. de Madrid, 15, Beiro, 18012 Granada, Spain. FAU - Garcia-Valdes, Luz Maria AU - Garcia-Valdes LM AUID- ORCID: 0000-0002-9254-0658 AD - Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Granada, 18012 Granada, Spain. AD - CIBER on Epidemiology and Public Health CIBEResp, Institute of Health Carlos III, 28029 Madrid, Spain. FAU - Verduci, Elvira AU - Verduci E AUID- ORCID: 0000-0003-2111-3111 AD - Pediatric Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. AD - Department of Health Sciences, University of Milan, 20122 Milan, Italy. FAU - Campoy, Cristina AU - Campoy C AUID- ORCID: 0000-0002-9860-6785 AD - Department of Pediatrics, School of Medicine,University of Granada, Avda. Jesus Candel Fabregas, 18016 Granada, Spain. AD - EURISTIKOS Excellence Centre for Pediatric Research, University of Granada, Avda. del Conocimiento, 19, 18016 Granada, Spain. AD - Instituto de Investigacion Biosanitaria de Granada (Ibs-GRANADA), Avda. de Madrid, 15, Beiro, 18012 Granada, Spain. AD - Institute of Neurosciences, Biomedical Research Centre, University of Granada, Avda. del Conocimiento, 19, 18012 Granada, Spain. AD - CIBER on Epidemiology and Public Health CIBEResp, Institute of Health Carlos III, 28029 Madrid, Spain. LA - eng GR - PREOBE Excellence Project Ref. P06-CTS-02341/Andalusian Government, Economy, Science and Innovation Ministry/ GR - SAF2015-69265-C2-1-R/Ministry of Economy and Competitiveness/ GR - EU Project HORIZON 2020 DynaHEALTH (GA No 633595)/European Commission/ PT - Journal Article DEP - 20261021 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Fatty Acids, Unsaturated) RN - 0 (Fatty Acids, Omega-6) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Child MH - *Body Composition MH - Adult MH - *Maternal Nutritional Physiological Phenomena MH - Body Mass Index MH - *Fatty Acids, Unsaturated/blood MH - *Pregnancy in Obesity/blood MH - Male MH - *Overweight/blood MH - Adiposity MH - Fatty Acids, Omega-6/blood MH - Developmental Origins of Health and Disease MH - *Obesity MH - Fetal Blood/chemistry MH - *Prenatal Exposure Delayed Effects PMC - PMC13708055 OTO - NOTNLM OT - arachidonic acid (ARA) OT - childhood body composition OT - developmental programming OT - dihomo-gamma-linolenic acid (DGLA) OT - docosahexaenoic acid (DHA) OT - fatty acids OT - gamma-linolenic acid (GLA) OT - n-3 PUFAs OT - n-6 PUFAs OT - polyunsaturated fatty acids OT - pregnancy in obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/21 CRDT- 2026/10/27 10:44 PHST- 2026/07/06 00:00 [received] PHST- 2026/10/12 00:00 [revised] PHST- 2026/10/14 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:44 [entrez] PHST- 2026/10/21 00:00 [pmc-release] AID - nu18203453 [pii] AID - nutrients-18-03453 [pii] AID - 10.3390/nu18203453 [doi] PST - epublish SO - Nutrients. 2026 Oct 21;18(20):3453. doi: 10.3390/nu18203453. PMID- 42942963 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 16 TI - The Preterm Brain Is Also What It Eats: A Systematic Review of Nutrition and Neuroimaging Outcomes in Preterm Infants. LID - 10.3390/nu18203392 [doi] LID - 3392 AB - Background: Nutrition is one of the most modifiable determinants of brain development in preterm infants. Although increasing evidence supports associations between early nutritional exposures and neurodevelopment, studies remain heterogeneous regarding nutritional interventions, imaging biomarkers, and long-term outcomes. This systematic review aimed to summarize contemporary evidence on the relationship between nutrition and brain development in preterm infants using neuroimaging as the primary assessment tool while proposing an integrated translational framework to guide future research. Methods: Following a PECO framework, a systematic literature search was conducted in PubMed, Scopus, and CINAHL: population, infants born before 37 completed weeks of gestation; exposure, any enteral or parenteral nutritional exposure, supplementation strategy, fortification approach, or individualized nutritional intervention; comparator, an alternative nutritional strategy, lower or absent exposure, standard care or, when relevant, a term-born reference group; outcomes, MRI- or CUS-based measures of brain growth, maturation, connectivity, or injury. Studies reporting volumetric, morphometric, diffusion, connectivity, spectroscopy, or quantitative ultrasound outcomes were eligible. The methodology was adapted from the PROSPERO-registered review by Ottolini et al. Original studies published between 2020 and 2026 (1 January 2020-4 September 2026) evaluating nutritional exposures or interventions in preterm infants with magnetic resonance imaging (MRI) and/or cranial ultrasound (CUS) outcomes were included. Risk of bias was assessed using the Newcastle-Ottawa Scale (NOS), ROBINS-I and RoB 2 according to study design. Quantitative imaging studies were screened for eligibility for ATLAS assessment. Given the substantial heterogeneity in nutritional exposures, imaging protocols, timing of assessments, and neurodevelopmental outcomes, meta-analysis was not performed. Certainty of evidence was assessed at the level of each causal question and neuroimaging outcome domain using the GRADE framework. Randomized intervention evidence and observational exposure evidence were evaluated according to the design and target contrast contributing to each body of evidence. Judgments considered risk of bias, inconsistency, indirectness, imprecision, publication bias, and, where applicable, factors that could increase certainty. Statistical significance was not used to determine certainty, and studies arising from shared or partially overlapping parent populations were not counted as independent replication. Results: We found 33 reports that met the inclusion criteria: 4 evaluated randomized treatment contrasts, 5 non-randomized intervention comparisons, and 24 observational nutritional exposure analyses. Greater exposure to human milk and selected strategies involving early protein and lipid provision, docosahexaenoic acid, omega-3 fatty acids, and individualized nutritional support were associated in several studies with favorable MRI measurements, including larger total or regional brain volumes, more advanced white-matter maturation, and differences in structural or functional connectivity. Some studies also reported associations with later neurodevelopment. However, findings were not uniform, and GRADE certainty across outcome-specific nutrition-neuroimaging questions ranged from very low to low, principally because of risk of bias, imprecision, heterogeneous exposure and imaging definitions, and limited independent replication. Although causal inference cannot be directly drawn, neuroimaging may provide quantitative measures of brain development that can be investigated alongside long-term neurodevelopmental outcomes. We propose the Roadmap for Imaging-Guided Enhancement of Neurodevelopment (RIGEL), an integrative research framework combining imaging, molecular biomarkers, standardized neurodevelopmental assessment, and epidemiological evidence across developmental stages. RIGEL should be regarded as a hypothesis-generating research framework that requires prospective validation before any clinical implementation. FAU - Canepa, Maria Ester AU - Canepa ME AUID- ORCID: 0009-0004-7400-1724 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. FAU - Prefumo, Federico AU - Prefumo F AUID- ORCID: 0000-0001-7793-714X AD - Obstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. FAU - Biagioli, Valentina AU - Biagioli V AUID- ORCID: 0009-0004-3021-6627 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. FAU - Striano, Pasquale AU - Striano P AUID- ORCID: 0000-0002-6065-1476 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. AD - Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. FAU - Calandrino, Andrea AU - Calandrino A AUID- ORCID: 0000-0002-2710-1798 AD - Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. FAU - Ramenghi, Luca Antonio AU - Ramenghi LA AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. AD - Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20261016 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Infant, Premature/growth & development MH - *Brain/growth & development/diagnostic imaging MH - Infant, Newborn MH - *Neuroimaging MH - *Infant Nutritional Physiological Phenomena MH - Neurodevelopment MH - *Nutritional Status MH - Magnetic Resonance Imaging MH - Female PMC - PMC13708710 OTO - NOTNLM OT - MRI OT - brain OT - development OT - growth OT - imaging OT - neonate OT - nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/16 CRDT- 2026/10/27 10:43 PHST- 2026/08/06 00:00 [received] PHST- 2026/09/12 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - nu18203392 [pii] AID - nutrients-18-03392 [pii] AID - 10.3390/nu18203392 [doi] PST - epublish SO - Nutrients. 2026 Oct 16;18(20):3392. doi: 10.3390/nu18203392. PMID- 42942960 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 16 TI - Complementary Feeding Practices and Nutritional Status Among Pakistani Children Aged 6-23 Months: A Pooled Analysis of Nationally Representative Surveys. LID - 10.3390/nu18203389 [doi] LID - 3389 AB - Background: Milk feeding practices are a critical determinant of nutritional status in infancy, yet the relationship between specific milk feeding combinations and undernutrition remains poorly characterized in Pakistan, where animal milk use is widespread and the malnutrition burden is among the highest in South Asia. Methods: We pooled data on 96,736 children aged 6-23 months with valid anthropometry from 13 nationally and provincially representative cross-sectional surveys (2010-2020). Analyses were restricted to Punjab, Sindh, Khyber Pakhtunkhwa and Balochistan. Seven mutually exclusive feeding combinations were defined from 24 h dietary recall. Survey-weighted, age-stratified logistic regression (6-11 and 12-23 months) examined associations with stunting and wasting, adjusting progressively for area, household and child-level factors, with breastfeeding plus complementary feeding as the reference. Micronutrient deficiency data from NNS 2011 and NNS 2018 were analyzed descriptively. Results: Among infants aged 6-11 months, non-human milk (NHM) alone-predominantly unfortified buffalo or cow milk-was independently associated with elevated odds of stunting (OR: 1.54, 95% CI: 1.20-1.96) and wasting (OR: 1.86, 95% CI: 1.42-2.45) in fully adjusted models. Among children aged 12-23 months, NHM with complementary foods (NHM+CF) was independently protective against both stunting (OR: 0.73, 95% CI: 0.66-0.80) and wasting (OR: 0.80, 95% CI: 0.72-0.89). Household poverty was the strongest determinant of undernutrition in every stratum. Anemia (59.1%), ferritin deficiency (50.4%), iron deficiency anemia (33.0%) and vitamin D deficiency (63.1%) remained highly prevalent in 2018, and were highest in children receiving milk without complementary foods. In contrast, multiple micronutrient deficiency was elevated across most NHM-containing feeding groups regardless of complementary food status; after adjustment, NHM+CF and BM+NHM remained independently associated with multiple micronutrient deficiency at 12-23 months (OR: 1.35, 95% CI: 1.04-1.77 and OR: 1.52, 95% CI: 1.05-2.20, respectively). Conclusions: The nutritional correlates of NHM use are strongly age-dependent: adverse in the first year when it substitutes for breast milk without complementary foods, and favorable after 12 months as part of a diversified diet. Feeding interventions should be embedded within poverty-reduction frameworks. All data were cross-sectional, so these associations are not causal. FAU - Rizvi, Arjumand AU - Rizvi A AUID- ORCID: 0000-0003-4553-8130 AD - Institute for Global Health and Development, The Aga Khan University, Karachi 74800, Pakistan. FAU - Bhutta, Afsah AU - Bhutta A AD - Centre for Global Child Health, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. FAU - Sajid, Muhammad AU - Sajid M AUID- ORCID: 0009-0001-3161-8116 AD - Center of Excellence in Women & Child Health, The Aga Khan University, Karachi 74800, Pakistan. FAU - Soofi, Sajid B AU - Soofi SB AUID- ORCID: 0000-0003-4192-8406 AD - Center of Excellence in Women & Child Health, The Aga Khan University, Karachi 74800, Pakistan. FAU - Bhutta, Zulfiqar A AU - Bhutta ZA AUID- ORCID: 0000-0003-0637-599X AD - Institute for Global Health and Development, The Aga Khan University, Karachi 74800, Pakistan. AD - Centre for Global Child Health, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. LA - eng PT - Journal Article DEP - 20261016 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Infant MH - Pakistan/epidemiology MH - *Nutritional Status MH - *Infant Nutritional Physiological Phenomena MH - Female MH - Cross-Sectional Studies MH - Male MH - Growth Disorders/epidemiology/etiology MH - Animals MH - Milk MH - Wasting Syndrome/epidemiology/etiology MH - Breast Feeding MH - Micronutrients/deficiency MH - Malnutrition/epidemiology MH - Infant Nutrition Disorders/epidemiology MH - *Feeding Behavior PMC - PMC13708651 OTO - NOTNLM OT - Pakistan OT - animal milk OT - breastfeeding OT - complementary feeding OT - infant and young child feeding OT - micronutrient deficiency OT - non-human milk OT - stunting OT - wasting COIS- The authors declare no conflict of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/16 CRDT- 2026/10/27 10:43 PHST- 2026/09/05 00:00 [received] PHST- 2026/10/12 00:00 [revised] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - nu18203389 [pii] AID - nutrients-18-03389 [pii] AID - 10.3390/nu18203389 [doi] PST - epublish SO - Nutrients. 2026 Oct 16;18(20):3389. doi: 10.3390/nu18203389. PMID- 42942926 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 13 TI - School-Based Rescued Produce Distribution, and Changes in Parental Fruit Intake and Household Dietary Behaviors: A Non-Randomized Controlled Cluster Trial. LID - 10.3390/nu18203355 [doi] LID - 3355 AB - Background/Objectives: Fruit and vegetable intake remains below recommended levels, particularly among families facing socioeconomic constraints. School-based food access interventions may improve household dietary behaviors. This study evaluated the association between participation in the "Leket Health" school-based rescued produce distribution program and changes in parental fruit and vegetable intake, nutrition-related parenting practices, and household food security. Children's fruit and vegetables intake was assessed as a secondary exploratory outcome. Methods: A non-randomized controlled cluster trial was conducted among parents (n = 281) of 4th-5th-grade students at three elementary schools in a peripheral town in Israel, with one school per study arm (three clusters in total). Schools were assigned to full intervention (biweekly fruit and vegetable boxes and nutrition education), partial intervention (boxes only), or control. Parent data were collected at baseline and after 7 months using both self-reported fruit and vegetable portions and a validated food frequency questionnaire (FFQ), food security questionnaire, and parental behavior questionnaire. Child intake was assessed using a study-specific FFQ. Primary analyses used a complete-case approach, supplemented by an allocation-based multiple-imputation sensitivity analysis among 269 identifiable participants. The trial was not registered in a public registry. Results: A total of 70% of enrolled participants completed the study. The two parental intake measures yielded discordant findings: categorical changes in parent-reported daily fruit servings differed across study groups in the complete-case analysis (p = 0.028), whereas FFQ-derived fruit and vegetable intake (g/day) showed no statistically significant between-group differences. The overall parenting-practices score showed no statistically significant change (p = 0.770) or between-group difference (p = 0.297). Household food insecurity increased from 8.7% to 14.3% and worsened across all study arms, with no significant between-group difference in deterioration (p = 0.810). No primary dietary endpoint was prespecified. In the allocation-based multiple-imputation analysis, adjusted follow-up fruit intake was higher than control by 0.38 portions/day (95% CI 0.04-0.71) in the full-intervention arm and 0.25 portions/day (95% CI -0.10 to 0.61) in the partial-intervention arm; estimates were attenuated under more adverse assumptions regarding missing outcomes. In an exploratory post-allocation adherence analysis, each additional produce box collected was associated with 6.7% higher odds of a parent-reported increase in fruit intake (OR = 1.067, 95% CI 1.003-1.135; p = 0.040). Among intervention participants, parent-reported improvements in nutrition-related parenting practices were associated with parent-reported increases in household vegetable variety (OR = 2.219, 95% CI 1.057-4.656; p = 0.035). These exploratory associations do not establish intervention effects. The overall parenting-practices score showed no statistically significant change (p = 0.770) or between-group difference (p = 0.297). Household food insecurity increased from 8.7% to 14.3% and worsened across all study arms, with no significant between-group difference in deterioration (p = 0.810). Among children, no significant changes were observed in FFQ-derived intake. Conclusions: Program participation was associated with higher parent-reported fruit servings, although the magnitude of between-arm differences varied across missing-data assumptions. No significant changes were observed in parental vegetable servings or FFQ-derived fruit and vegetable intake among parents or children. Given the single-school-per-arm design, these findings should be interpreted as exploratory and require confirmation in studies with multiple schools per arm. FAU - Hod-Ovadia, Smadar AU - Hod-Ovadia S AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. AD - Leket Israel, Ra'anana 43650, Israel. FAU - Kilzi, Moran AU - Kilzi M AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. AD - Leket Israel, Ra'anana 43650, Israel. FAU - Factor, Hagai AU - Factor H AD - Department of Psychology, Faculty of Humanities and Social Sciences, Ariel University, Ariel 40700, Israel. FAU - Boaz, Mona AU - Boaz M AUID- ORCID: 0000-0002-3920-7549 AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. FAU - Kaufman-Shriqui, Vered AU - Kaufman-Shriqui V AUID- ORCID: 0000-0003-3190-4187 AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. AD - The Center for Urban Health Solutions (C-UHS), St. Michael's Hospital, Toronto, ON M5B 1T8, Canada. LA - eng GR - Leket Israel/ GR - Ariel University/ PT - Journal Article DEP - 20261013 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Fruit MH - *Vegetables MH - Male MH - Female MH - Child MH - *Parents MH - *Feeding Behavior MH - Schools MH - Israel MH - Parenting MH - *Diet MH - Family Characteristics MH - *School Health Services MH - Food Supply MH - Food Security PMC - PMC13708734 OTO - NOTNLM OT - food rescue OT - food security OT - fruit and vegetable intake OT - nutrition education OT - nutrition equity OT - parental dietary behavior OT - produce distribution OT - school-based intervention COIS- Leket Israel funded the study and implemented the Leket Health intervention program. S.H.-O. and M.K. are employed by Leket Israel, the organization that operates the Leket Health program. This employment is disclosed as a competing interest. To support research independence, data were collected using structured questionnaires, and statistical analyses were conducted by an external statistician using de-identified data. The authors declare no other conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/13 CRDT- 2026/10/27 10:43 PHST- 2026/09/02 00:00 [received] PHST- 2026/10/07 00:00 [revised] PHST- 2026/10/09 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - nu18203355 [pii] AID - nutrients-18-03355 [pii] AID - 10.3390/nu18203355 [doi] PST - epublish SO - Nutrients. 2026 Oct 13;18(20):3355. doi: 10.3390/nu18203355. PMID- 42942917 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 13 TI - Social Dynamics Are Associated with Plant-Based Dietary Consumption Patterns Among Rural Adults in the U.S. LID - 10.3390/nu18203346 [doi] LID - 3346 AB - BACKGROUND/OBJECTIVES: Social dynamics are known to influence eating behaviors and differ across geographic contexts. Some evidence suggests healthy plant-based diets (PBDs) are associated with reduced risk of chronic diseases, morbidity and mortality, and have lower environmental burdens. This paper examines the role of social influence, expectations, and pressures in consumption of PBDs among rural residents in the United States, with attention to gender differences. METHODS: National survey data from rural adults (n = 2210) were analyzed using adjusted logistic regression models including an interaction between social beliefs and gender, and qualitative interviews (n = 55) thematically explored gendered social influences on PBD patterns. RESULTS: Results showed that perceived expectations from important members of the respondents' social network were positively associated with PBD adherence (p < 0.001), without a significant overall interaction with gender (p = 0.163). Perceived social pressure was also associated with PBD adherence overall (p = 0.009), and the association differed by gender (interaction p = 0.001), but did not show a consistent trend across levels of agreement. Qualitative findings suggested that family members influenced the feasibility of PBD, while friends were more commonly described as supportive. Women appeared to face challenges to enacting a PBD when family members (especially male partners) were not supportive. CONCLUSIONS: These results suggest social relationships have complex and gendered roles in shaping PBD among rural residents in the United States. FAU - Alvirdizadeh, Sevda AU - Alvirdizadeh S AUID- ORCID: 0000-0002-2178-9448 AD - Food Systems Program, University of Vermont, Burlington, VT 05405, USA. AD - Gund Institute for Environment, University of Vermont, Burlington, VT 05405, USA. FAU - Abdul-Rahaman, Saadatu AU - Abdul-Rahaman S AUID- ORCID: 0009-0003-7241-750X AD - Food Systems Program, University of Vermont, Burlington, VT 05405, USA. AD - Gund Institute for Environment, University of Vermont, Burlington, VT 05405, USA. FAU - Seguin-Fowler, Rebecca A AU - Seguin-Fowler RA AUID- ORCID: 0000-0002-5115-2341 AD - Institute for Advancing Health Through Agriculture, Texas A&M AgriLife Research, College Station, TX 77843, USA. AD - Department of Nutrition, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX 77843, USA. FAU - Belarmino, Emily H AU - Belarmino EH AUID- ORCID: 0000-0002-5505-1214 AD - Food Systems Program, University of Vermont, Burlington, VT 05405, USA. AD - Gund Institute for Environment, University of Vermont, Burlington, VT 05405, USA. AD - Department of Nutrition and Food Sciences, University of Vermont, Burlington, VT 05405, USA. LA - eng GR - Hatch project 1025975/National Institute of Food and Agriculture/ PT - Journal Article DEP - 20261013 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - United States MH - *Rural Population/statistics & numerical data MH - Adult MH - Middle Aged MH - *Diet, Plant-Based MH - Aged MH - *Feeding Behavior MH - Sex Factors MH - Social Group MH - Young Adult MH - Social Support MH - Adolescent MH - *Diet, Healthy/psychology PMC - PMC13708334 OTO - NOTNLM OT - food systems OT - plant-based diet OT - rural America OT - social norms COIS- RASF is owner and director of strongpeopleprogram.org. No other authors have COIs to declare. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/13 CRDT- 2026/10/27 10:43 PHST- 2026/09/02 00:00 [received] PHST- 2026/10/02 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - nu18203346 [pii] AID - nutrients-18-03346 [pii] AID - 10.3390/nu18203346 [doi] PST - epublish SO - Nutrients. 2026 Oct 13;18(20):3346. doi: 10.3390/nu18203346. PMID- 42942880 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 9 TI - New Vitamin and Mineral Supplements: Acceptability, Tolerability, and Short-Term Adherence in a Paediatric Cohort with IMDs. LID - 10.3390/nu18203309 [doi] LID - 3309 AB - Background/Objectives: Dietary therapy for inherited metabolic disorders (IMDs) can restrict nutrient-dense foods and increase reliance on vitamin and mineral supplementation. However, formulation-related barriers may limit supplement acceptability and adherence, particularly in children with feeding difficulties and complex dietary regimens. We evaluated the acceptability, gastrointestinal (GI) tolerability, and short-term adherence of two novel low-carbohydrate, low-volume vitamin and mineral formulations in children and adolescents with IMDs. Methods: This prospective, single-centre, open-label, non-randomised interventional study enrolled children and adolescents with IMDs aged >/=1 year who were either taking vitamin and mineral supplements already or were clinically identified as requiring micronutrient supplementation. Participants replaced their usual vitamin and mineral supplement with one of two age-appropriate study formulations (product A or B) for 7 consecutive days under usual home conditions. Acceptability was assessed using structured questionnaires, GI symptoms were assessed at baseline and on day 7 and monitored using daily diaries, and adherence was recorded daily by caregivers. Clinical characteristics and anthropometric measurements were assessed at baseline. Results: Thirty-one participants (median age, 7.2 years; range, 2.1-16.6) were enrolled; 15 were allocated to study product A and 16 to study product B, with 14 and 15 participants, respectively, completing the 7-day intervention. Full-dose intake (always or mostly) during the 7-day study period was reported in 27/30 (90.0%) participants. Among evaluable participants, GI symptoms improved or remained unchanged in 12/13 (92.3%) receiving product A and in 12/14 (85.7%) receiving product B. Mean acceptability scores improved for both product A (from 2.4 to 1) and product B (from 2.2 to 0.4), with lower scores indicating greater acceptability. Overall preference for the study product was reported by 10/14 (71.4%) participants receiving product A and 15/15 (100%) receiving product B. At the end of the study, 6/14 (42.9%) participants receiving product A and 7/15 (46.7%) receiving product B elected to continue to use the study product. Conclusions: In this exploratory study, two low-carbohydrate, low-volume vitamin and mineral formulations demonstrated favourable short-term acceptability, GI tolerability, and adherence in children and adolescents with IMDs. These findings suggest that formulation characteristics and ease of administration may influence the practical feasibility of micronutrient supplementation in this population. However, the short seven-day study duration and absence of a control group limit interpretation of these findings. Larger, longer-term studies are warranted to determine whether these benefits are sustained and whether improved acceptability and adherence translate into improved micronutrient status and clinical outcomes. FAU - Tosi, Martina AU - Tosi M AUID- ORCID: 0000-0003-4859-5288 AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Evans, Sharon AU - Evans S AUID- ORCID: 0000-0002-7654-3621 AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Yilmaz Nas, Ozlem AU - Yilmaz Nas O AUID- ORCID: 0000-0002-2941-9505 AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Daly, Anne AU - Daly A AUID- ORCID: 0000-0003-2579-8699 AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Pinto, Alex AU - Pinto A AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Ackrill, Julia AU - Ackrill J AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Ashmore, Catherine AU - Ashmore C AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - MacDonald, Anita AU - MacDonald A AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. LA - eng PT - Journal Article DEP - 20261009 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Vitamins) RN - 0 (Minerals) SB - IM MH - Humans MH - Adolescent MH - Child MH - *Dietary Supplements/adverse effects MH - Female MH - Male MH - Child, Preschool MH - *Vitamins/administration & dosage/adverse effects MH - Prospective Studies MH - *Metabolic Diseases/drug therapy MH - *Patient Acceptance of Health Care MH - *Patient Compliance MH - *Minerals/administration & dosage/adverse effects PMC - PMC13708595 OTO - NOTNLM OT - children OT - inherited metabolic disorders OT - micronutrient deficiency OT - mineral supplementation OT - multivitamin OT - palatability OT - product acceptability OT - restricted diet OT - vitamin supplementation COIS- M.T. has received research fundings from Vitaflo International, British Inherited Metabolic Disease Group (BIMDG, Cambridge, UK), National Society for Phenylketonuria UK (NSPKU, Chesterfield, UK) and Galen (Craigavon, UK) and grants from Vitaflo International, Nutricia, PIAM (Genoa, Italy), Applied Pharma Research (Balerna, Switzerland), Galen, PTC Therapeutics (Warren, NJ, USA) and MetaX (Shanghai, China) to attend scientific meetings; S.E. has received research funding from Vitaflo International and Nutricia; O.Y.N. has received research fundings from the Scientific and Technological Research Council of Turkey (TUBITAK), NSPKU, Vitaflo International, and PTC Therapeutics, and grants from BioMarin (San Rafael, CA, USA), Vitaflo International and LogixX Pharma (Reading, UK) to attend scientific meetings; A.D. is an advisory board member Arla (Viby J, Denmark), Vitaflo International and PTC Pharmaceuticals, and has received research funding and honoraria from Nutricia, Vitaflo International, Meta Healthcare (Hemel Hempstead, UK), Galen, Arla, PTC and Metax. A.P. received an educational grant from Cambrooke Therapeutics (Ayer, MA, USA) and Biomarin and grants from Vitaflo International, Nutricia, Biomarin, Mevalia (Burgstall, Italy), Galen, PIAM, Applied Pharma Research, PTC Therapeutics and LogixX Pharma to attend scientific meetings; A.M. is an advisory board member for Arla and receives research funding from Vitaflo International, Nutricia and Metax. J.A. and C.A. declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/09 CRDT- 2026/10/27 10:43 PHST- 2026/09/03 00:00 [received] PHST- 2026/10/04 00:00 [revised] PHST- 2026/10/05 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - nu18203309 [pii] AID - nutrients-18-03309 [pii] AID - 10.3390/nu18203309 [doi] PST - epublish SO - Nutrients. 2026 Oct 9;18(20):3309. doi: 10.3390/nu18203309. PMID- 42942739 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 1999-4923 (Print) IS - 1999-4923 (Electronic) IS - 1999-4923 (Linking) VI - 18 IP - 10 DP - 2026 Sep 23 TI - Beyond Creatinine: D-Amino Acids as Emerging Indicators of Kidney Function and Disease. LID - 10.3390/pharmaceutics18101207 [doi] LID - 1207 AB - Despite decades of clinical use, serum creatinine and cystatin C remain imperfect indicators of kidney function, being influenced by muscle mass, age, sex, and inflammation and often showing limited sensitivity to early renal injury. D-amino acids (D-AAs), once largely regarded as by-products of microbial metabolism, have emerged as biologically active chiral metabolites with promising potential for improving the assessment of renal function and disease. This review synthesizes current mechanistic, analytical, and clinical evidence on D-AAs in chronic kidney disease, tracing their origins in diet, gut microbiota, and endogenous racemization through their stereoselective renal transport, tubular handling, and urinary excretion. Among these molecules, D-serine and D-asparagine have emerged as particularly promising biomarkers, showing strong associations with measured glomerular filtration rate and, in early studies, performance comparable or superior to conventional markers, though evidence remains limited to small or selected cohorts, while appearing less dependent on body composition across adult and pediatric populations. Beyond their biomarker potential, D-AAs participate in signaling and metabolic processes linking the gut, kidney, and brain, with altered D-AA homeostasis implicated in both renal injury and uremic neurological dysfunction. We critically examine the biological and clinical confounders, analytical challenges, and validation gaps that currently limit their translation into clinical practice and discuss how chiral metabolomics could contribute to a more precise assessment of kidney function and disease. FAU - Uifalean, Alina AU - Uifalean A AUID- ORCID: 0000-0003-1297-6345 AD - Department of Pharmaceutical Analysis, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Iacobescu, Maria AU - Iacobescu M AUID- ORCID: 0000-0002-0659-8926 AD - Department of Personalized Medicine and Rare Diseases, MEDFUTURE-Institute for Biomedical Research, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Muresan, Ximena Maria AU - Muresan XM AD - Department of Personalized Medicine and Rare Diseases, MEDFUTURE-Institute for Biomedical Research, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Heghes, Simona Codruta AU - Heghes SC AUID- ORCID: 0000-0001-7823-4390 AD - Department of Pharmaceutical Analysis, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Salanta, Liana Claudia AU - Salanta LC AUID- ORCID: 0000-0003-2435-405X AD - Department of Food Science, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania. FAU - Moldovan, Radu-Cristian AU - Moldovan RC AUID- ORCID: 0000-0002-2847-1301 AD - Department of Personalized Medicine and Rare Diseases, MEDFUTURE-Institute for Biomedical Research, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Iuga, Cristina-Adela AU - Iuga CA AUID- ORCID: 0000-0002-0345-0993 AD - Department of Pharmaceutical Analysis, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. AD - Department of Personalized Medicine and Rare Diseases, MEDFUTURE-Institute for Biomedical Research, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. LA - eng GR - 32154/4/16.12.2024/Iuliu Hatieganu University of Medicine and Pharmacy/ PT - Journal Article PT - Review DEP - 20260923 PL - Switzerland TA - Pharmaceutics JT - Pharmaceutics JID - 101534003 PMC - PMC13708084 OTO - NOTNLM OT - D-amino acids OT - D-asparagine OT - D-serine OT - biomarkers OT - chiral metabolomics OT - chronic kidney disease OT - gut-kidney axis COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/09/23 CRDT- 2026/10/27 10:43 PHST- 2026/08/25 00:00 [received] PHST- 2026/09/20 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - pharmaceutics18101207 [pii] AID - pharmaceutics-18-01207 [pii] AID - 10.3390/pharmaceutics18101207 [doi] PST - epublish SO - Pharmaceutics. 2026 Sep 23;18(10):1207. doi: 10.3390/pharmaceutics18101207. PMID- 42942225 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 16 IP - 10 DP - 2026 Sep 30 TI - Foot Posture Outweighs Habitual Footwear in Discriminating Concurrent Lower-Limb Pain in Children: A Cross-Sectional Interpretable Machine-Learning Study. LID - 10.3390/life16101639 [doi] LID - 1639 AB - Lower-limb pain is common in school-aged children, but the relative contributions of foot posture, adiposity, and footwear remain uncertain, and prediction models may be inflated by target leakage. We aimed to quantify how well foot posture, adiposity, and footwear discriminate current lower-limb pain, and whether machine learning outperforms penalised logistic regression. We analysed a cross-sectional school-based dataset of 4408 children aged 4-14 years from Turkiye. Eight classifiers were trained with five-fold cross-validation and evaluated once in a held-out 20% test set; pain-site information was excluded from the primary predictors because it encoded the outcome. Test values of the area under the receiver operating characteristic curve (AUROC) ranged from 0.945 to 0.962; extremely randomised trees (0.961; 95% CI 0.942-0.977) did not outperform penalised logistic regression (DeltaAUROC 0.0003, 95% CI -0.0075 to 0.0095; p = 0.99). Foot posture alone reached an AUROC of 0.909, whereas demographics plus anthropometry reached 0.704, and adding footwear increased this only to 0.723. Therefore, concurrent lower-limb pain was discriminated mainly by foot posture and adiposity, while footwear and algorithmic complexity added little. As posture and pain were recorded concurrently, the models discriminate current rather than future pain. The findings are most relevant to first-contact assessment in general practice. FAU - Buyukcelebi, Hakan AU - Buyukcelebi H AUID- ORCID: 0000-0002-5504-6917 AD - Department of Coaching Education, Faculty of Sport Sciences, Inonu University, Malatya 44000, Turkiye. FAU - Acak, Mahmut AU - Acak M AD - Department of Coaching Education, Faculty of Sport Sciences, Canakkale Onsekiz Mart University, Canakkale 17100, Turkiye. FAU - Eken, Ozgur AU - Eken O AUID- ORCID: 0000-0002-5488-3158 AD - Department of Physical Education and Sport Teaching, Faculty of Sport Sciences, Inonu University, Malatya 44280, Turkiye. FAU - Atalan, Abdulkadir AU - Atalan A AUID- ORCID: 0000-0003-0924-3685 AD - Department of Industrial Engineering, Faculty of Engineering, Canakkale Onsekiz Mart University, Canakkale 17100, Turkiye. FAU - Sanal, Alperen AU - Sanal A AUID- ORCID: 0000-0002-6852-8990 AD - Department of Coaching Education, Faculty of Sport Sciences, Canakkale Onsekiz Mart University, Canakkale 17100, Turkiye. FAU - Yalcin, Ebru AU - Yalcin E AD - Department of Coaching Education, Faculty of Sport Sciences, Canakkale Onsekiz Mart University, Canakkale 17100, Turkiye. FAU - Bakhsh, Hadeel R AU - Bakhsh HR AUID- ORCID: 0000-0002-3000-880X AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Aldhahi, Monira I AU - Aldhahi MI AUID- ORCID: 0000-0002-5255-4860 AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng GR - PNURSP2026R286/Princess Nourah bint Abdulrahman University/ PT - Journal Article DEP - 20260930 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC13706620 OTO - NOTNLM OT - SHAP OT - diagnostic prediction model OT - explainable artificial intelligence OT - flatfoot OT - foot pain OT - foot posture OT - footwear OT - machine learning OT - paediatric lower-limb pain COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/09/30 CRDT- 2026/10/27 10:41 PHST- 2026/08/31 00:00 [received] PHST- 2026/09/23 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:41 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - life16101639 [pii] AID - life-16-01639 [pii] AID - 10.3390/life16101639 [doi] PST - epublish SO - Life (Basel). 2026 Sep 30;16(10):1639. doi: 10.3390/life16101639. PMID- 42941262 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2218-1989 (Print) IS - 2218-1989 (Electronic) IS - 2218-1989 (Linking) VI - 16 IP - 10 DP - 2026 Oct 16 TI - Nutrition, T-2 Toxin, and Gut Microbiota in Kashin-Beck Disease: Current Evidence and Proposed Links Within the Microbiota-Gut-Osteochondral Framework. LID - 10.3390/metabo16100787 [doi] LID - 787 AB - Kashin-Beck disease (KBD) is an endemic osteoarthropathy characterized by the degeneration and necrosis of articular cartilage and epiphyseal growth plate cartilage, with disease onset occurring predominantly during childhood. Its etiology has long been associated with environmental and nutritional factors, particularly selenium deficiency, T-2 toxin exposure, and dietary imbalance. Recent studies have also reported alterations in gut microbial composition and metabolic profiles in patients with KBD, raising the possibility that the gut microbiota may represent an additional component of its multifactorial etiology. This narrative review critically evaluates current evidence linking nutritional factors, T-2 toxin exposure, gut microbial alterations, and osteochondral injury in KBD, with particular attention to the level of evidence supporting these relationships. Direct human evidence is currently limited to a small number of predominantly cross-sectional microbiome and metabolomic studies, largely involving adults with established KBD. KBD-related experimental models provide evidence that selenium deficiency and T-2 toxin exposure can induce osteochondral injury, including combined-exposure effects, and experimental studies also indicate that these exposures can be associated with alterations in gut microbial composition. However, these findings do not demonstrate that gut microbial changes mediate exposure-related osteochondral injury. Proposed pathways involving short-chain fatty acids (SCFAs), intestinal-barrier dysfunction, lipopolysaccharide (LPS)-related inflammatory signaling, immune regulation, and bone remodeling are supported mainly by experimental or mechanistic evidence from non-KBD settings and have not been validated as an integrated causal pathway in KBD. The microbiota-gut-osteochondral framework should therefore be regarded as an evidence-stratified, hypothesis-generating model. Prospective studies in children and adolescents from endemic areas, together with factorial exposure models, direct measurement of proposed intermediate mediators, and functional microbiota-manipulation experiments, are needed to determine whether gut microbial alterations contribute causally to KBD development. FAU - Liu, Yang AU - Liu Y AD - Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Wang, Chaowei AU - Wang C AUID- ORCID: 0009-0005-9351-600X AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Cui, Liangyu AU - Cui L AD - Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Guo, Xiong AU - Guo X AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Wang, Xi AU - Wang X AUID- ORCID: 0000-0003-2983-5485 AD - Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Ning, Yujie AU - Ning Y AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. LA - eng GR - 82273752/National Natural Science Foundation of China/ GR - 82373700/National Natural Science Foundation of China/ PT - Journal Article PT - Review DEP - 20261016 PL - Switzerland TA - Metabolites JT - Metabolites JID - 101578790 PMC - PMC13706950 OTO - NOTNLM OT - Kashin-Beck disease OT - T-2 toxin OT - dietary factors OT - gut microbiota OT - microbiota-gut-osteochondral framework COIS- The authors declare no conflict of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/16 CRDT- 2026/10/27 10:38 PHST- 2026/08/07 00:00 [received] PHST- 2026/10/14 00:00 [revised] PHST- 2026/10/14 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:38 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - metabo16100787 [pii] AID - metabolites-16-00787 [pii] AID - 10.3390/metabo16100787 [doi] PST - epublish SO - Metabolites. 2026 Oct 16;16(10):787. doi: 10.3390/metabo16100787. PMID- 42940748 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 18 TI - From Type 2 Inflammation to Mucociliary Dysfunction: Individualized Pulmonary Rehabilitation in Children with Asthma and Bronchiectasis. LID - 10.3390/children13101430 [doi] LID - 1430 AB - Asthma and bronchiectasis may coexist in children, particularly in those with severe or difficult-to-treat respiratory disease, creating a complex clinical setting in which airway inflammation, bronchial hyperresponsiveness, mucus retention, impaired mucociliary clearance, recurrent infection, and functional impairment interact. This review critically examines the interacting pathophysiological mechanisms involving Type 2 airway inflammation, mucus hypersecretion and plugging, mucociliary dysfunction, infection, and structural airway injury in children with coexisting asthma and bronchiectasis. Particular attention is given to the functional consequences of this interaction, including exercise intolerance, physical deconditioning, respiratory muscle dysfunction, and reduced participation in daily life and age-appropriate physical activity. Available evidence on airway-clearance techniques, structured exercise training, respiratory muscle training, and the management of exercise-induced bronchoconstriction is critically evaluated, with pediatric evidence clearly distinguished from adult-derived extrapolations. We propose a mechanism-informed rehabilitation framework in which interventions are tailored to the predominant clinical and functional features of each child, including mucus retention, bronchial hyperresponsiveness, reduced exercise capacity, respiratory muscle impairment, and functional decline associated with recurrent exacerbations. This multidisciplinary approach integrates airway-clearance techniques, individualized exercise training, optimized asthma management, infection control, and longitudinal functional reassessment. Evidence specifically addressing children with coexisting asthma and bronchiectasis remains limited, and prospective pediatric studies are required to validate individualized rehabilitation strategies and determine their impact on long-term respiratory and patient-centered outcomes. FAU - Vidrighin, Anca AU - Vidrighin A AD - Department of Paediatrics, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania. FAU - Juganaru, Iulius AU - Juganaru I AUID- ORCID: 0009-0000-6879-145X AD - Department XI of Pediatrics, Discipline I of Pediatrics, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. AD - Department of Pediatrics I, "Louis Turcanu" Children's Emergency Hospital, 300011 Timisoara, Romania. FAU - Iovin, Valentin-Cristian AU - Iovin VC AUID- ORCID: 0009-0004-1552-7961 AD - Doctoral School Department, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. FAU - Diaconu, Cosmina AU - Diaconu C AUID- ORCID: 0000-0003-4845-8953 AD - Department of Nursing and Dental Medicine, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania. AD - Clinic of Physical Medicine and Rehabilitation, County Clinical Emergency Hospital Sibiu, 550245 Sibiu, Romania. FAU - Neamtu, Andreea-Adriana AU - Neamtu AA AUID- ORCID: 0000-0002-5219-5466 AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. AD - Department of Pathology, Clinical County Emergency Hospital of Arad, 310037 Arad, Romania. AD - Department of Pathology, "Pius Brinzeu" Clinical County Emergency Hospital, 300723 Timisoara, Romania. FAU - Sarau, Cristian AU - Sarau C AUID- ORCID: 0000-0002-1938-1443 AD - Medical Semiology I, Department V Internal Medicine I, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. FAU - Lighezan, Diana Luisa AU - Lighezan DL AUID- ORCID: 0009-0002-8001-7672 AD - Department of Hematology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Diaconu, Cristinel Gabriel AU - Diaconu CG AUID- ORCID: 0009-0005-9133-4384 AD - Department of Physiology, Faculty of Medicine, Lucian Blaga University of Sibiu, Lucian Blaga Street 2A, 550169 Sibiu, Romania. AD - Department of Radiology, Pneumology and Tuberculosis Hospital, 550196 Sibiu, Romania. FAU - Porr, Corina AU - Porr C AUID- ORCID: 0009-0000-7255-0835 AD - Allergology Department, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania. AD - Allergology Department, County Clinical Emergency Hospital Sibiu, Bulevardul Corneliu Coposu 2-4, 550245 Sibiu, Romania. LA - eng PT - Journal Article PT - Review DEP - 20261018 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703761 OTO - NOTNLM OT - Type 2 inflammation OT - airway clearance OT - bronchiectasis OT - exercise training OT - exercise-induced bronchoconstriction OT - mucociliary dysfunction OT - pediatric asthma OT - pulmonary rehabilitation OT - respiratory muscle training COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/18 CRDT- 2026/10/27 10:37 PHST- 2026/09/06 00:00 [received] PHST- 2026/10/02 00:00 [revised] PHST- 2026/10/16 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/18 00:00 [pmc-release] AID - children13101430 [pii] AID - children-13-01430 [pii] AID - 10.3390/children13101430 [doi] PST - epublish SO - Children (Basel). 2026 Oct 18;13(10):1430. doi: 10.3390/children13101430. PMID- 42940723 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 14 TI - Children's Perception of Parental Body Size and Its Association with Their Desire to Be Like the Parent. LID - 10.3390/children13101404 [doi] LID - 1404 AB - BACKGROUND: Childhood obesity is a major and growing public health challenge worldwide. Although parental misperception of children's weight is well documented, how children perceive their parents' body size and whether parental body size is associated with children's expressed desire to be like the parent have received little attention. We examined children's perception of parental body size and whether parental BMI was associated with their expressed desire to be like the parent in a primary care sample. METHODS: This single-center, cross-sectional study included 229 parent-child pairs consecutively recruited from a family medicine outpatient clinic in Turkiye between January and March 2026. Children aged 4-8 years rated the accompanying parent's body size and reported whether they wanted to be like that parent, while parents independently rated their own body size. The BMI-based Body Size Guide was used for all figure selections, and the classification derived from objectively measured parental BMI served as the primary reference. Agreement was evaluated using Cohen's kappa coefficients, associations were examined using multivariable logistic regression, and the children's spontaneous explanations were examined using qualitative content analysis. RESULTS: Parents showed moderate weighted agreement with the BMI-derived classification (weighted kappa = 0.536, 95% CI: 0.456-0.612; exact agreement: 59.4%), whereas children showed fair weighted agreement (weighted kappa = 0.315, 95% CI: 0.231-0.392; exact agreement: 42.8%). After adjustment for child age, child sex, child weight status, parent sex, and parent age, parental overweight (aOR = 0.353, 95% CI: 0.170-0.733) and parental obesity (aOR = 0.133, 95% CI: 0.057-0.307) were associated with lower odds of the child reporting a desire to be like the parent. After adjustment for child age, child sex, parent sex, and parent age, parental overweight (aOR = 2.818, 95% CI: 1.101-7.211) and parental obesity (aOR = 4.774, 95% CI: 1.816-12.546) were associated with higher odds of child overweight/obesity. Among the 53 children who provided an explanation, responses referred to body size, weight, health, appearance, affection, and identification with the parent, illustrating the broad interpretation of the question. CONCLUSIONS: Children aged 4-8 years were able to rate parental body size, although their agreement with the BMI-derived classification was limited. Children's expressed desire to be like the parent varied according to parental BMI; however, this broad question may reflect emotional, relational, behavioural, and appearance-related considerations rather than bodily resemblance alone. The open-ended responses provide context by showing that only some children spontaneously referred to body size or weight. These findings support further research using developmentally validated and stigma-sensitive measures to clarify how young children perceive parental body size and interpret questions about identification with a parent. FAU - Kurt, Abdullah Kaan AU - Kurt AK AUID- ORCID: 0000-0002-6302-6035 AD - Department of Family Medicine, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkiye. FAU - Karakullukcu, Serdar AU - Karakullukcu S AUID- ORCID: 0000-0001-7673-7699 AD - Department of Public Health, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkiye. LA - eng PT - Journal Article DEP - 20261014 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703376 OTO - NOTNLM OT - body image OT - body size OT - child OT - parent-child relations OT - pediatric obesity COIS- The authors declare that they have no competing interests. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/14 CRDT- 2026/10/27 10:37 PHST- 2026/09/07 00:00 [received] PHST- 2026/10/01 00:00 [revised] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - children13101404 [pii] AID - children-13-01404 [pii] AID - 10.3390/children13101404 [doi] PST - epublish SO - Children (Basel). 2026 Oct 14;13(10):1404. doi: 10.3390/children13101404. PMID- 42940711 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 13 TI - Implementation Determinants and System-Level Barriers in Supplementary Feeding Programs for Children Under Five in Low- and Middle-Income Countries: A Critical Narrative Review. LID - 10.3390/children13101392 [doi] LID - 1392 AB - Background: Supplementary feeding programs are widely used to prevent or manage child undernutrition, but their population-level benefit depends on implementation. Objective: To critically synthesize multilevel determinants of program reach, continuity, utilization, equity and sustainability in low- and middle-income countries (LMICs). Methods: We conducted a critical narrative review of peer-reviewed and grey literature identified through iterative database searching and targeted verification. Sources were charted by setting, design, program, implementation determinant, consequence, evidence directness, limitation and narrative credibility. Direct, related and indirect evidence were weighted differently in the synthesis. Results: Direct and related evidence most consistently linked program performance to financing and supply continuity, workforce preparation and supervision, food acceptability, caregiver understanding, equitable access and monitoring linked to corrective action. Direct evidence was concentrated in South Asia and selected programs in Indonesia, Iran and Ethiopia. Evidence concerning digital delivery, father-inclusive approaches, community-health-worker incentives and donor transition was largely indirect and supports hypotheses rather than established program effects. Conclusions: Reliable delivery systems and effective child-level utilization are necessary for supplementary feeding programs to contribute to nutritional outcomes. Recommendations supported mainly by indirect evidence require prospective evaluation in supplementary feeding settings, particularly in underrepresented LMIC regions. FAU - Patni, Mohamed Anas AU - Patni MA AUID- ORCID: 0000-0001-6948-3619 AD - Department of Community Medicine, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates. AD - Department of Community Medicine, School of Epidemiology and Public Health, Jawaharlal Nehru Medical College, Adani Institute of Higher Education and Research, Wardha 442107, India. FAU - Choudhari, Sonali G AU - Choudhari SG AUID- ORCID: 0000-0003-0642-5096 AD - Department of Community Medicine, School of Epidemiology and Public Health, Jawaharlal Nehru Medical College, Adani Institute of Higher Education and Research, Wardha 442107, India. FAU - George, Biji Thomas AU - George BT AUID- ORCID: 0000-0001-5029-7779 AD - Department of General Surgery, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates. FAU - Salama, Rasha Aziz Attia AU - Salama RAA AUID- ORCID: 0000-0002-1102-9306 AD - Department of Community Medicine, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates. AD - Department of Community Medicine, Kasr El Aini Faculty of Medicine, Cairo University, Cairo 11956, Egypt. FAU - Bahutair, Shadha Nasser AU - Bahutair SN AUID- ORCID: 0009-0002-6427-1355 AD - Department of Obstetrics & Gynecology, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates. FAU - Akikwala, Mushirabanu Sharifmiyan AU - Akikwala MS AD - Department of Pediatrics, Shifa Al Jazeera Medical Centre, Ras Al Khaimah 11172, United Arab Emirates. LA - eng PT - Journal Article PT - Review DEP - 20261013 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703596 OTO - NOTNLM OT - child undernutrition OT - community health workers OT - equity OT - health systems OT - implementation science OT - low- and middle-income countries OT - program sustainability OT - supplementary feeding COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/13 CRDT- 2026/10/27 10:37 PHST- 2026/08/30 00:00 [received] PHST- 2026/10/10 00:00 [revised] PHST- 2026/10/12 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - children13101392 [pii] AID - children-13-01392 [pii] AID - 10.3390/children13101392 [doi] PST - epublish SO - Children (Basel). 2026 Oct 13;13(10):1392. doi: 10.3390/children13101392. PMID- 42940677 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 7 TI - Overlap of Subcutaneous Adiposity Across World Health Organization Body Mass Index-for-Age Categories and Anthropometric Correlates of Handgrip Strength in Children Aged 6-12 Years Participating in Organised Club Sport in Buenos Aires, Argentina. LID - 10.3390/children13101358 [doi] LID - 1358 AB - Background/Objectives: Body mass index (BMI) is the most widely used screening tool in paediatric nutritional assessment, but it does not measure body fat directly and conveys no information on muscular development. We aimed to (i) compare the sum of six skinfolds (Sigma6ST) across World Health Organization (WHO) BMI-for-age categories, accounting for age; (ii) quantify the distributional overlap of Sigma6ST between categories; (iii) examine how closely each individual skinfold tracks the remaining subcutaneous adiposity; and (iv) examine the associations of upper-limb girths with handgrip strength before and after adjustment for body size. Methods: This was a cross-sectional study of a convenience sample of 196 children (129 boys, 67 girls) aged 6-12 years engaged in organised club sport in Moron, Buenos Aires, Argentina. International Society for the Advancement of Kinanthropometry (ISAK)-certified anthropometrists measured six skinfolds and relaxed arm, corrected arm and forearm girths; handgrip strength was assessed with a digital dynamometer. Analyses used Kruskal-Wallis and Brunner-Munzel tests, age-adjusted log-linear models with robust standard errors, kernel-density overlap coefficients (OVLs) with bootstrap confidence intervals, and zero-order and partial Spearman correlations. Results: In this sample, 47.3% of boys and 43.3% of girls were classified as having overweight or obesity. Age distributions were similar across BMI categories, and Sigma6ST differed across categories after age adjustment (p < 0.001 in both sexes). Adjacent WHO categories nevertheless overlapped substantially (OVL = 0.44-0.57), and the two halves of the normal-weight range overlapped by up to 0.757. Single skinfolds correlated strongly with the sum of the remaining five (rho = 0.777-0.945) but estimated Sigma6ST with a median absolute error of 8.5-14.1%. Handgrip strength correlated most strongly with body size (stature in boys, rho = 0.723; body mass in girls, rho = 0.759). After adjustment for age, body mass and stature, it remained associated with corrected arm girth (partial rho = 0.346 and 0.336) but not with relaxed arm girth. Conclusions: BMI-for-age categories separate groups on average but carry limited information about an individual child's subcutaneous adiposity. Skinfolds and corrected arm girth are low-cost complements to BMI whose individual-level value requires validation against criterion methods. FAU - Gimenez, Mariano Jose AU - Gimenez MJ AUID- ORCID: 0009-0008-6135-3519 AD - Catedra de Nutricion y Deporte, Escuela de Nutricion, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121A6B, Argentina. AD - Red Iberoamericana de Investigadores en Antropometria Aplicada, 04120 Almeria, Spain. FAU - Herrera-Amante, Carlos Abraham AU - Herrera-Amante CA AUID- ORCID: 0000-0002-3645-3621 AD - Red Iberoamericana de Investigadores en Antropometria Aplicada, 04120 Almeria, Spain. AD - Laboratorio de Evaluacion y Cuidado del Estado Nutricio, Centro Universitario de Tonala, Division de Ciencias de la Salud, Universidad de Guadalajara, Tonala 45425, Jalisco, Mexico. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty of Education and Humanities, School of Sport Sciences, Universidad Andres Bello, Vina del Mar 2520000, Chile. AD - Department of Sport Sciences, Faculty of Sport and Health Sciences, Fit Generation Research Institute, AD500 Andorra la Vella, Andorra. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno 5290000, Chile. LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13702943 OTO - NOTNLM OT - anthropometry OT - body composition OT - body mass index OT - child OT - hand strength OT - paediatric obesity OT - skinfold thickness OT - youth sport COIS- M.J.G., C.A.H.-A., and R.Y.-S. are certified Level Three Anthropometrists (Instructors) by the International Society for the Advancement of Kinanthropometry (ISAK), who have received honoraria for teaching anthropometry courses and participating in international conferences. These professional interests relate to the field of anthropometry, which is the subject of the present manuscript, and are disclosed for full transparency; they did not influence the design, analysis or reporting of the study, and no author received any payment related to this manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/07 CRDT- 2026/10/27 10:37 PHST- 2026/09/02 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - children13101358 [pii] AID - children-13-01358 [pii] AID - 10.3390/children13101358 [doi] PST - epublish SO - Children (Basel). 2026 Oct 7;13(10):1358. doi: 10.3390/children13101358. PMID- 42940674 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 5 TI - Orthorexia Symptoms in Adolescents: Associations with Sociocultural Attitudes Toward Appearance and Body Composition. LID - 10.3390/children13101355 [doi] LID - 1355 AB - BACKGROUND/OBJECTIVES: Orthorexic symptoms in adolescence may be associated with sociocultural appearance influences, but their relationship with objective body composition remains unclear. This study examined associations between orthorexic symptoms, sociocultural attitudes toward appearance, and body composition in adolescents. METHODS: This cross-sectional study included 287 Polish secondary-school students aged 14-18 years. Orthorexic symptoms were assessed using the Dusseldorf Orthorexia Scale (DOS), sociocultural attitudes using the Sociocultural Attitudes Towards Appearance Questionnaire-3 (SATAQ-3), and body composition by bioelectrical impedance analysis. Correlation and multiple linear regression analyses were performed. RESULTS: DOS scores correlated positively with SATAQ-3 pressure/internalization (r = 0.407, p < 0.001), athletic internalization (r = 0.330, p < 0.001), and Information (r = 0.385, p < 0.001). These associations remained robust in Spearman sensitivity analyses. The regression model including four SATAQ-3 subscales, percentage body fat (PBF), sex, and age explained 19.2% of DOS-score variance (adjusted R(2) = 0.172; F(7.279) = 9.49, p < 0.001). Pressure/internalization (beta = 0.190, p = 0.053) and Information (beta = 0.162, p = 0.060) did not reach conventional statistical significance. The remaining predictors were not independently associated with DOS scores. CONCLUSIONS: Orthorexic symptom severity was associated with appearance-related sociocultural variables at the bivariate level, but individual predictors were not independently significant in the adjusted model. These findings identify sociocultural factors as relevant correlates without establishing causality or excluding a role for body composition. Longitudinal studies using adolescent-validated measures and direct assessments of digital exposure are needed. FAU - Kiciak, Agata AU - Kiciak A AUID- ORCID: 0000-0002-4531-2038 AD - Department of Food Technology and Quality Assessment, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Staskiewicz, Wiktoria AU - Staskiewicz W AUID- ORCID: 0000-0003-2420-5935 AD - Department of Food Technology and Quality Assessment, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Kuczka-Marek, Natalia AU - Kuczka-Marek N AUID- ORCID: 0009-0007-2144-6318 AD - Doctoral School, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. FAU - Bialek-Dratwa, Agnieszka AU - Bialek-Dratwa A AUID- ORCID: 0000-0002-7798-6424 AD - Department of Human Nutrition, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Sapala, Anna-Maria AU - Sapala AM AUID- ORCID: 0009-0009-2558-5600 AD - Department of Dietetics and Food Science, Faculty of Science, Natural and Technical Sciences, Jan Dlugosz University in Czestochowa, Aleja Armii Krajowej 13/15, 42-200 Czestochowa, Poland. FAU - Jaruga-Sekowska, Sylwia AU - Jaruga-Sekowska S AUID- ORCID: 0000-0003-0142-2013 AD - Department of Health Promotion, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Piekarska 18, 41-902 Bytom, Poland. FAU - Kardas, Marek AU - Kardas M AUID- ORCID: 0000-0002-4810-1025 AD - Department of Food Technology and Quality Assessment, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. AD - Food Industry School, Franciszkanska 13, 41-819 Zabrze, Poland. FAU - Barczynska, Renata AU - Barczynska R AUID- ORCID: 0000-0002-4161-6480 AD - Department of Dietetics and Food Science, Faculty of Science, Natural and Technical Sciences, Jan Dlugosz University in Czestochowa, Aleja Armii Krajowej 13/15, 42-200 Czestochowa, Poland. LA - eng PT - Journal Article DEP - 20261005 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703725 OTO - NOTNLM OT - adolescent mental health OT - body image OT - orthorexia nervosa OT - sociocultural pressure COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/05 CRDT- 2026/10/27 10:37 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - children13101355 [pii] AID - children-13-01355 [pii] AID - 10.3390/children13101355 [doi] PST - epublish SO - Children (Basel). 2026 Oct 5;13(10):1355. doi: 10.3390/children13101355. PMID- 42940616 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Sep 24 TI - Health-Related Behaviors and BMI Across Three School Years: Annual Bayesian Network Patterns During the PETICA Childhood Obesity Prevention Program. LID - 10.3390/children13101298 [doi] LID - 1298 AB - Background/Objectives: This study examined annual probabilistic network structures among dietary habits, health-related attitudes, lifestyle behaviors, and body mass index (BMI) during implementation of the PETICA school-based program. Methods: This was a three-year prospective, uncontrolled school-based intervention with repeated measurements of the same cohort in Grades 2-4. The BMI analytic samples comprised 915 pupils in Grade 2 (461 boys, 454 girls; mean age 7.9 +/- 0.4), 840 in Grade 3 (429 boys, 411 girls; mean age 8.9 +/- 0.5), and 684 in Grade 4 (341 boys, 343 girls; mean age 9.9 +/- 0.4). BMI was recalculated from measured body mass and height and used as the continuous network outcome. BMI-for-age percentiles were retained for age- and sex-specific descriptive classification and sensitivity analysis. Separate score-based Bayesian networks were estimated for each grade. Network stability was assessed using 200 nonparametric bootstrap samples, with stable adjacency defined as a bootstrap frequency of at least 50%. Results: Fruit and vegetable intake formed a stable adjacency in all three grades, with bootstrap frequencies of 100.0% in Grade 2, 98.0% in Grade 3, and 99.0% in Grade 4. The sex of the pupil and computer/video-game use were stably connected in Grades 3 and 4 (100.0% in both grades). Stable connections among health-related attitudes were more prominent in later grades. In Grade 4, at-home breakfast consumption was connected with water intake (57.5%) and vegetable intake (52.0%). No behavioral adjacency with continuous BMI reached the prespecified 50% stability threshold in any grade. The largest subthreshold behavior-BMI signal was observed for at-home breakfast consumption in Grade 4 (39.0%). Conclusions: Selected relationships among reported health-related behaviors were reproducible across annual assessments, whereas direct behavior-BMI connections were year-specific and did not reach the stability threshold. The greater integration of attitudes and healthy habits in later grades is compatible with cumulative, age-adapted health education, but the absence of an untreated comparison group prevents attribution of these patterns to PETICA. The findings do not establish causal effects or program effectiveness, but may contribute to hypotheses generation for future evaluations of multi-component school-based obesityprevention programs. FAU - Cobal Pravdic, Sara AU - Cobal Pravdic S AUID- ORCID: 0000-0001-6956-6887 AD - Croatian Medical Association, Subiceva 9, 10000 Zagreb, Croatia. FAU - Vranesic Bender, Darija AU - Vranesic Bender D AD - Unit of Clinical Nutrition, Department of Internal Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia. FAU - Gajdos Kljusuric, Jasenka AU - Gajdos Kljusuric J AUID- ORCID: 0000-0001-6657-7337 AD - Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia. FAU - Kazazic, Ema AU - Kazazic E AD - School of Medicine, University of Zagreb, Salata 2, 10000 Zagreb, Croatia. FAU - Krznaric, Zeljko AU - Krznaric Z AD - Croatian Medical Association, Subiceva 9, 10000 Zagreb, Croatia. AD - Unit of Clinical Nutrition, Department of Internal Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia. AD - School of Medicine, University of Zagreb, Salata 2, 10000 Zagreb, Croatia. FAU - Kurtanjek, Zelimir AU - Kurtanjek Z AD - Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia. LA - eng GR - Croatian Medical Association/ PT - Journal Article DEP - 20260924 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703612 OTO - NOTNLM OT - BMI OT - BMI-for-age percentiles OT - Bayesian networks OT - dietary habits OT - lifestyle behaviors OT - prospective study OT - public-health program "PETICA" COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/09/24 CRDT- 2026/10/27 10:36 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:36 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - children13101298 [pii] AID - children-13-01298 [pii] AID - 10.3390/children13101298 [doi] PST - epublish SO - Children (Basel). 2026 Sep 24;13(10):1298. doi: 10.3390/children13101298. PMID- 42939470 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2079-7737 (Print) IS - 2079-7737 (Electronic) IS - 2079-7737 (Linking) VI - 15 IP - 20 DP - 2026 Oct 16 TI - Maternal Pharmaceutical Intake, Tobacco Smoking, and Environmental Pesticide Exposures: High-Resolution Serum Pesticide Screening, Longitudinal Fetal Ultrasound Biometry, and Postnatal Anogenital Distance in a Brazilian Cohort. LID - 10.3390/biology15201869 [doi] LID - 1869 AB - Maternal lifestyle exposures and pharmaceutical consumption during gestation represent key modulators of intrauterine growth and reproductive tract programming. This prospective cohort study evaluated the associations of maternal clinical history, medication use, and tobacco smoking with serial fetal ultrasound biometry, AGD, and postnatal infant anthropometry. A cohort of 51 pregnant women was prospectively enrolled during the first trimester (14 days). Outcomes included postoperative complications, time to full enteral feeding, hospital stay, and mortality. RESULTS: Sixteen infants met inclusion criteria. Of these, 7 (43.8%) underwent early repair and 9 (56.2%) underwent delayed repair. There were no significant differences in comorbidities or overall complication rates between groups. Time to full feeds was shorter in the early repair group (median 11 vs 40 days, p = 0.013). No surgery-related deaths occurred (0 [0%] in both groups). DISCUSSION: Early repair of DA in stable preterm or VLBW infants is feasible and safe when undertaken by experienced teams. Surgical timing should be guided by physiological stability rather than arbitrary gestational or weight thresholds. Further studies are needed to refine evidence-based guidelines. FAU - Ali, M A A AU - Ali MAA FAU - Boam, T AU - Boam T FAU - Paran, S AU - Paran S LA - eng PT - Journal Article DEP - 20261022 PL - Ireland TA - Ir Med J JT - Irish medical journal JID - 0430275 RN - Familial duodenal atresia SB - IM MH - Humans MH - Infant, Newborn MH - Retrospective Studies MH - *Duodenal Obstruction/surgery MH - Female MH - Infant, Premature MH - Male MH - Length of Stay/statistics & numerical data MH - Infant, Low Birth Weight MH - *Intestinal Atresia/surgery MH - Infant, Very Low Birth Weight MH - Postoperative Complications/epidemiology MH - Time Factors MH - Treatment Outcome COIS- None declared. EDAT- 2026/10/27 11:31 MHDA- 2026/10/27 11:32 CRDT- 2026/10/27 07:21 PHST- 2026/10/27 11:32 [medline] PHST- 2026/10/27 11:31 [pubmed] PHST- 2026/10/27 07:21 [entrez] PST - epublish SO - Ir Med J. 2026 Oct 22;119(9):177. PMID- 42937050 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1541-0420 (Electronic) IS - 0006-341X (Print) IS - 0006-341X (Linking) VI - 82 IP - 4 DP - 2026 Oct 7 TI - Bayesian multiple imputation for functional data. LID - 10.1093/biomtc/ujag182 [doi] LID - ujag182 AB - Missing data are pervasive in modern functional datasets, where trajectories are often sparsely or irregularly observed. Although functional principal component analysis is widely used to reconstruct incomplete curves, existing approaches typically employ single imputation, leading to overly optimistic inferences in downstream analyses. To address these challenges, we develop a novel Bayesian multiple imputation framework for functional data (BAMIFun). For single-level functional data, we impose a Bayesian low-rank model that incorporates penalized spline representations to enforce smoothness of the functional domain and derive an efficient Gibbs sampler algorithm for posterior computation. In addition, we demonstrate and validate how to properly account for estimation uncertainties in downstream analysis. Furthermore, we extend the framework to multiway functional data using Functional Tensor Singular Value Decomposition model, enabling Bayesian multiple imputation in settings not supported by existing methods. Simulation studies show that BAMIFun achieves substantially improved coverage and more reliable downstream inference compared to existing methods, while maintaining similar imputation accuracy. Case studies using a physical activity dataset and an infant gut microbiome dataset further demonstrate the practical advantages of our proposed methods under severe missingness. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of The International Biometric Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Jiang, Ziren AU - Jiang Z AUID- ORCID: 0000-0002-5830-327X AD - Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN 55414, United States. FAU - Xuan, Lei AU - Xuan L AD - Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN 55414, United States. FAU - Lock, Eric F AU - Lock EF AUID- ORCID: 0000-0003-4663-2356 AD - Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN 55414, United States. FAU - Cui, Erjia AU - Cui E AD - Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN 55414, United States. LA - eng GR - R01HL187193/NH/NIH HHS/United States GR - R21LM014912/NH/NIH HHS/United States GR - R35GM161467/NH/NIH HHS/United States PT - Journal Article PL - England TA - Biometrics JT - Biometrics JID - 0370625 SB - IM MH - Bayes Theorem MH - Computer Simulation MH - Algorithms MH - *Models, Statistical MH - Humans MH - Data Interpretation, Statistical MH - Biometry/methods PMC - PMC13711057 OTO - NOTNLM OT - Bayesian inference OT - functional data analysis OT - missing data OT - multiple imputation OT - multiway data COIS- None declared. EDAT- 2026/10/27 11:31 MHDA- 2026/10/27 11:32 PMCR- 2027/10/27 CRDT- 2026/10/27 07:06 PHST- 2026/04/01 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/10/27 11:32 [medline] PHST- 2026/10/27 11:31 [pubmed] PHST- 2026/10/27 07:06 [entrez] PHST- 2027/10/27 00:00 [pmc-release] AID - 9002789 [pii] AID - ujag182 [pii] AID - 10.1093/biomtc/ujag182 [doi] PST - ppublish SO - Biometrics. 2026 Oct 7;82(4):ujag182. doi: 10.1093/biomtc/ujag182. PMID- 42936840 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 1178-2390 (Print) IS - 1178-2390 (Electronic) IS - 1178-2390 (Linking) VI - 19 DP - 2026 TI - Family-Inclusive Interventions Supporting Complementary Feeding for Children Aged 6-23 Months: A Scoping Review of Alignment with Family-Centered Care Principles. PG - 644384 LID - 10.2147/JMDH.S644384 [doi] LID - 644384 AB - Suboptimal complementary-feeding practices remain an important concern for child nutrition and growth. WHO and UNICEF guidance emphasizes appropriate complementary feeding for children aged 6-23 months, including dietary adequacy, responsive feeding, and supportive caregiving. Because many interventions primarily target mothers, broader family involvement may be underrepresented. This scoping review aimed to map the characteristics, implementation strategies, and reported outcomes of family-inclusive complementary-feeding interventions and examined their alignment with established Family-Centered Care (FCC) principles. The review followed Joanna Briggs Institute guidance and PRISMA-ScR recommendations. PubMed, Scopus, CINAHL via EBSCOhost, and ScienceDirect were searched for English- or Indonesian-language primary intervention or programme-evaluation studies with extractable quantitative data published from January 2016 to May 3, 2026. Eligibility was structured using the Population, Concept, and Context framework, and included publications were synthesized descriptively and mapped against established FCC principles. Eleven publications representing 10 underlying studies or trials met the eligibility criteria. Information Sharing and Participation were evident in all 11 publications, Dignity and Respect in eight, and explicit Collaboration in two. Across the 10 underlying studies or trials, four recurring family-inclusive patterns were identified: paternal engagement, family empowerment and teamwork, responsive parenting, and community ecosystem integration. These were interpreted as evidence-informed descriptive categories rather than validated FCC dimensions. Reported outcomes were heterogeneous, with favorable findings for selected feeding, caregiver, parenting, growth, and developmental outcomes alongside null or mixed findings. Family-inclusive interventions commonly incorporated information sharing and active caregiver participation, whereas explicit partnership-oriented Collaboration was less frequently reported. Future research should examine how FCC principles can be intentionally operationalized and evaluated in relation to implementation, sustainability, and contextual adaptation. This conceptual mapping may inform future intervention development without implying comparative effectiveness. CI - (c) 2026 Cahaya et al. FAU - Cahaya, Annisa Putri AU - Cahaya AP AUID- ORCID: 0009-0008-6957-2302 AD - Master of Nursing Program, Faculty of Nursing, Universitas Padjadjaran, Sumedang, West Java, Indonesia. FAU - Rhamelani, Putri AU - Rhamelani P AUID- ORCID: 0000-0003-4602-6022 AD - Master of Nursing Program, Faculty of Nursing, Universitas Padjadjaran, Sumedang, West Java, Indonesia. FAU - Nurhidayah, Ikeu AU - Nurhidayah I AUID- ORCID: 0000-0002-9286-1056 AD - Department of Maternity and Pediatric Nursing, Faculty of Nursing, Universitas Padjadjaran, Sumedang, West Java, Indonesia. FAU - Mediani, Henny Suzana AU - Mediani HS AUID- ORCID: 0000-0001-6960-3692 AD - Department of Maternity and Pediatric Nursing, Faculty of Nursing, Universitas Padjadjaran, Sumedang, West Java, Indonesia. LA - eng PT - Journal Article PT - Review DEP - 20261022 PL - New Zealand TA - J Multidiscip Healthc JT - Journal of multidisciplinary healthcare JID - 101512691 PMC - PMC13703957 OTO - NOTNLM OT - complementary feeding OT - family involvement OT - family-centered care OT - family-inclusive interventions OT - scoping review COIS- The authors report no conflicts of interest in this work. EDAT- 2026/10/27 16:33 MHDA- 2026/10/27 16:34 PMCR- 2026/10/22 CRDT- 2026/10/27 06:53 PHST- 2026/07/29 00:00 [received] PHST- 2026/10/10 00:00 [accepted] PHST- 2026/10/27 16:34 [medline] PHST- 2026/10/27 16:33 [pubmed] PHST- 2026/10/27 06:53 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - 644384 [pii] AID - 10.2147/JMDH.S644384 [doi] PST - epublish SO - J Multidiscip Healthc. 2026 Oct 22;19:644384. doi: 10.2147/JMDH.S644384. eCollection 2026. PMID- 42935885 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 20 DP - 2026 Dec TI - Synthesized cardiometabolic, pulmonary, and sleep outcomes after bariatric surgery in adolescents with severe obesity: A systematic review and meta-analysis. PG - 100341 LID - 10.1016/j.obpill.2026.100341 [doi] LID - 100341 AB - BACKGROUND: To synthesize cardiometabolic, pulmonary, sleep-related, anthropometric, and safety outcomes after metabolic and bariatric surgery in adolescents with severe obesity. METHODS: This was a systematic review and meta-analysis conducted according to PRISMA 2020 and prospectively registered in PROSPERO (CRD420261354795). Five databases were searched for studies of adolescents aged approximately 10-19 years undergoing recognized metabolic or bariatric procedures. Two reviewers independently performed study selection, data extraction, and risk-of-bias assessment. Random-effects meta-analysis was used when studies were sufficiently comparable. RESULTS: Of 5110 records, 147 reports representing 101 unique studies or cohorts published from 1995 to 2026 were included. Follow-up ranged from 30 days to approximately 15 years. Across three independent randomized cohorts, surgery reduced body mass index by 9.39 kg/m(2) at 2 years versus non-surgical care (95% CI -13.90 to -4.89; I(2) = 88%; low certainty). Randomized evidence indicated lower triglycerides (mean difference -0.36 mmol/L, 95% CI -0.57 to -0.14; low certainty), whereas blood-pressure effects were indeterminate (very low certainty). Observational cohorts reported improvement or remission of type 2 diabetes, hypertension, dyslipidemia, and obstructive sleep apnea. Weight reduction was durable after gastric bypass and sleeve gastrectomy but smaller and less durable after gastric banding. Repeat objective sleep testing was reported in three studies and postoperative spirometry in one. No included report documented use of a validated asthma-control instrument, ambulatory blood-pressure monitoring, or vascular imaging as a pre- and postoperative outcome; diastolic function was reported once; diastolic function was reported once. Perioperative mortality and serious 30-day complications were uncommon, whereas reoperation and micronutrient deficiency remained important during extended follow-up. CONCLUSIONS: Metabolic and bariatric surgery produces large body mass index reductions and multisystem improvement in adolescents with severe obesity; serious short-term complications and perioperative mortality were uncommon, but lifelong nutritional and multidisciplinary surveillance remains important. Most effect estimates remain uncertain, particularly for objective long-term sleep and pulmonary outcomes. FAU - Lal, Purushottam AU - Lal P AD - Department of Pediatric Pulmonology, Allergy, Immunology and Sleep Medicine, Yale New Haven Children's Hospital, New Haven, CT, 06510, USA. FAU - Kumar, Nitin AU - Kumar N AD - St. Christopher's Hospital for Children, Philadelphia, PA, 19134, USA. FAU - Gupta, Surendra AU - Gupta S AD - Clinica Sierra Vista, Fresno, CA, USA. FAU - Agrawal, Sabhyata AU - Agrawal S AD - Department of Pediatric Pulmonology, Allergy, Immunology and Sleep Medicine, Yale New Haven Children's Hospital, New Haven, CT, 06510, USA. FAU - Gupta, Abhishek AU - Gupta A AD - Department of Oral Medicine and Radiology, Chitwan Medical College, Bharatpur, Chitwan, 44207, Nepal. LA - eng PT - Journal Article PT - Review DEP - 20261009 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13697805 OTO - NOTNLM OT - Bariatric surgery OT - Cardiometabolic outcomes OT - Obesity OT - Obstructive OT - Pulmonary function OT - Severe OT - Sleep apnea OT - adolescent COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 16:33 MHDA- 2026/10/27 16:34 PMCR- 2026/10/09 CRDT- 2026/10/27 05:58 PHST- 2026/08/25 00:00 [received] PHST- 2026/10/02 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/27 16:34 [medline] PHST- 2026/10/27 16:33 [pubmed] PHST- 2026/10/27 05:58 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - S2667-3681(26)00097-5 [pii] AID - 100341 [pii] AID - 10.1016/j.obpill.2026.100341 [doi] PST - epublish SO - Obes Pillars. 2026 Oct 9;20:100341. doi: 10.1016/j.obpill.2026.100341. eCollection 2026 Dec. PMID- 42935836 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2235-2988 (Electronic) IS - 2235-2988 (Linking) VI - 16 DP - 2026 TI - Factors associated with severe disease and in-hospital mortality in children with non-HIV-associated Pneumocystis jirovecii pneumonia: a single-center retrospective cohort study. PG - 1937817 LID - 10.3389/fcimb.2026.1937817 [doi] LID - 1937817 AB - OBJECTIVE: To identify factors associated with severe Pneumocystis jirovecii pneumonia (PJP) and in-hospital mortality and evaluate their ability to discriminate severe PJP in children without human immunodeficiency virus (HIV) infection. METHODS: This single-center retrospective cohort study included 61 children with non-HIV-associated PJP admitted between February 2022 and June 2025, including 31 with non-severe and 30 with severe PJP. Univariable and multivariable Firth penalized logistic regression identified factors associated with severe PJP, and receiver operating characteristic curves assessed discrimination. A restricted Firth logistic model explored in-hospital mortality among severe cases. RESULTS: Thirty children (49.2%) had severe PJP, and nine (14.8%) died during hospitalization; all deaths occurred in the severe group. Compared with the non-severe group, the severe group had more frequent primary immunodeficiency, fever, dyspnea, and cytomegalovirus (CMV) coinfection; higher D-dimer, lactate dehydrogenase (LDH), procalcitonin, and CT severity scores; and lower albumin, PaO(2)/FiO(2), and CD4(+)/CD8(+) T-cell ratios (all P<0.05). In the primary multivariable model, LDH (per 100-U/L increase: adjusted odds ratio [aOR]=1.532, 95% confidence interval [CI]: 1.061-2.374; P = 0.021) and CMV coinfection (aOR=5.164, 95% CI: 1.099-28.048; P = 0.037) were associated with severe PJP. LDH remained significant in the sensitivity analysis, whereas CMV coinfection did not. LDH discriminated severe from non-severe PJP with an area under the curve of 0.868 (95% CI: 0.776-0.960); the optimal cutoff was 423.0 U/L, with 90.0% sensitivity and 71.0% specificity. The combined model had an AUC of 0.878 (95% CI: 0.791-0.966), without significant improvement over LDH alone (P = 0.701). Among severe cases, non-survivors had more frequent malnutrition and CMV coinfection, higher LDH and procalcitonin, and lower neutrophil counts, albumin, PaO(2)/FiO(2), and CD4(+)/CD8(+) T-cell ratios (all P<0.05). In the exploratory mortality model, LDH (per 100-U/L increase: aOR=1.654, 95% CI: 1.080-4.271; P = 0.018) and albumin (per 1-g/L increase: aOR=0.605, 95% CI: 0.251-0.878; P = 0.004) were associated with in-hospital mortality. CONCLUSIONS: Elevated LDH was consistently associated with severe PJP and showed good discrimination. CMV coinfection was associated with severe PJP only in the primary model and provided no significant incremental discrimination. Elevated LDH and decreased albumin may be associated with in-hospital mortality. Larger external cohorts are needed to validate these findings. CI - Copyright (c) 2026 Ning, Chen, Yu, Tang and Qiao. FAU - Ning, Junjie AU - Ning J AD - Department of Scientific Research, Zigong First People's Hospital, Zigong, Sichuan, China. AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Chen, Dan AU - Chen D AD - Department of Pediatrics, Meishan People's Hospital, Meishan, Sichuan, China. FAU - Yu, Zhidong AU - Yu Z AD - Department of Pediatrics, Zigong First People's Hospital, Zigong, Sichuan, China. FAU - Tang, Fajuan AU - Tang F AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Qiao, Lina AU - Qiao L AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. LA - eng PT - Journal Article DEP - 20261012 PL - Switzerland TA - Front Cell Infect Microbiol JT - Frontiers in cellular and infection microbiology JID - 101585359 SB - IM MH - Humans MH - *Pneumonia, Pneumocystis/mortality/microbiology MH - Retrospective Studies MH - *Pneumocystis carinii/pathogenicity MH - *Hospital Mortality MH - Infant MH - Child, Preschool MH - Female MH - Male MH - ROC Curve MH - Severity of Illness Index MH - Risk Factors MH - Child MH - Coinfection PMC - PMC13696267 OTO - NOTNLM OT - Pneumocystis jirovecii pneumonia OT - children OT - in-hospital mortality OT - lactate dehydrogenase OT - non-HIV-associated OT - severe disease COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/27 16:33 MHDA- 2026/10/27 16:34 PMCR- 2026/10/12 CRDT- 2026/10/27 05:53 PHST- 2026/07/14 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/27 16:34 [medline] PHST- 2026/10/27 16:33 [pubmed] PHST- 2026/10/27 05:53 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - 10.3389/fcimb.2026.1937817 [doi] PST - epublish SO - Front Cell Infect Microbiol. 2026 Oct 12;16:1937817. doi: 10.3389/fcimb.2026.1937817. eCollection 2026. PMID- 42935813 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Outcomes of gastrostomy in children with neurological impairment: a systematic review. PG - 1963093 LID - 10.3389/fped.2026.1963093 [doi] LID - 1963093 AB - INTRODUCTION: Gastrostomy feeding is widely used for children with neurological impairment and inadequate oral intake, but evidence across family-important outcomes has not been synthesised. Previous systematic reviews were restricted to cerebral palsy and found no controlled studies. The objective of this study is to assess gastrostomy vs. continued oral/nasogastric feeding on nutritional, respiratory, neurodevelopmental, and caregiver-reported outcomes, and to quantify complications. METHODS: A PROSPERO-registered systematic review (CRD420261483110) was conducted following PRISMA 2020 guidelines. Five databases were searched to 15 July 2026 for children aged 0-18 with neurological impairment undergoing gastrostomy. Duplicate screening, data extraction, and risk-of-bias appraisal (RoB 2, ROBINS-I, JBI, CASP) were performed. Heterogeneity precluded meta-analysis; narrative synthesis prioritized study design and methodological quality over direction-of-effect vote counting. RESULTS: From 5,503 records, 120 studies ( approximately 117 cohorts, 30 countries) met the criteria. The evidence was predominantly observational, and most comparative studies carried a serious risk of bias. Nutritional status improved in the majority of 56 studies, though earlier placement's association with more robust catch-up growth does not establish causality. Among 56 respiratory studies, smaller cohorts reported fewer infections, but the largest propensity-matched and population-linked datasets showed no reduction, and in some analyses an increase, in pneumonia hospitalisations. Minor complications were common (20%-95%). Major complications clustered at 0%-3% without concurrent antireflux surgery, but rose several-fold when fundoplication or jejunal extensions were added. Reflux outcomes (59 studies) depended on preoperative status; it is hypothesized from limited physiological data that gastrostomy may increase de novo reflux risk in previously reflux-free children, though <10% required subsequent antireflux surgery. All-cause mortality (67 studies) was high but disease-related; procedure-attributable death was rare, and 30-day mortality was 0%-3% outside the most fragile groups. Quality-of-life data (21 studies) showed favourable caregiver outcomes in 14/17 studies, but the child's quality of life has been measured properly only once and was unchanged. Only 11 studies addressed neurodevelopment; the single study using a standardised instrument found cognitive recovery unrelated to the feeding route. DISCUSSION: Gastrostomy is consistently associated with improved weight-based nutritional status and carries low serious surgical harm when performed without concurrent antireflux surgery. It does not eliminate aspiration risk and is hypothesized to increase de novo reflux risk in previously reflux-free children. Caregiver quality of life improves on validated measurement; however, the available evidence is insufficient to determine whether gastrostomy has a favourable, unfavourable, or neutral effect on a child's neurodevelopment. SYSTEMATIC REVIEW REGISTRATION: PROSPERO: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261483110. CI - (c) 2026 Ibrahim, Jummakhan, Dawood, Siam, Alhusami, Khan, Mokhtar, Benamer and Babiker. FAU - Ibrahim, Mariam Kamel AU - Ibrahim MK AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Jummakhan, Hafeeza AU - Jummakhan H AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Dawood, Malak AU - Dawood M AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Siam, Mariam AU - Siam M AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Alhusami, Minat Allah AU - Alhusami MA AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Khan, Sara AU - Khan S AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Mokhtar, Jonathan AU - Mokhtar J AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. AD - Research and Graduate Studies, Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai Health, Dubai, United Arab Emirates. FAU - Benamer, Hani T S AU - Benamer HTS AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Babiker, Mohamed O E AU - Babiker MOE AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. AD - Pediatrics, Dubai Health, Dubai, United Arab Emirates. LA - eng PT - Journal Article PT - Systematic Review DEP - 20261012 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13696405 OTO - NOTNLM OT - aspiration pneumonia OT - cerebral palsy OT - children OT - dysphagia OT - enteral nutrition OT - gastrostomy OT - neurological impairment OT - systematic review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/27 16:33 MHDA- 2026/10/27 16:34 PMCR- 2026/10/12 CRDT- 2026/10/27 05:52 PHST- 2026/08/09 00:00 [received] PHST- 2026/08/30 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/27 16:34 [medline] PHST- 2026/10/27 16:33 [pubmed] PHST- 2026/10/27 05:52 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - 10.3389/fped.2026.1963093 [doi] PST - epublish SO - Front Pediatr. 2026 Oct 12;14:1963093. doi: 10.3389/fped.2026.1963093. eCollection 2026. PMID- 42935742 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - IL-33/ST2 signalling in pediatric food allergy and eosinophilic gastrointestinal disorders: a systematic review of human and preclinical evidence. PG - 1961426 LID - 10.3389/fimmu.2026.1961426 [doi] LID - 1961426 AB - BACKGROUND: Interleukin-33 (IL-33) is an epithelial-derived member of the IL-1 cytokine family that functions as an alarmin and signals through the ST2 receptor, upstream of type 2 inflammation. Together with thymic stromal lymphopoietin (TSLP) and IL-25, it constitutes an epithelial alarmin triad that orchestrates barrier-related immune responses. Despite substantial mechanistic data, the specific role of IL-33 as a biomarker and therapeutic target in pediatric food-related allergic disease remains insufficiently defined. OBJECTIVE: This systematic review aims to synthesize current evidence on serum and tissue IL-33 in pediatric IgE-mediated food allergy and eosinophilic gastrointestinal disorders (EGIDs), to delineate its association with disease severity, clinical phenotype and oral immunotherapy (OIT) outcomes, and to critically appraise the IL-33/ST2 axis as a candidate biomarker and therapeutic target within the broader epithelial alarmin network. METHODS: A systematic search of PubMed/MEDLINE, Web of Science, Scopus and the Cochrane Library (2010-2026) identified pediatric clinical studies quantifying IL-33 or IL-33/ST2 in food allergy or EGIDs, alongside murine and in vitro studies directly interrogating IL-33-dependent mechanisms in food allergy models. Eligible studies were screened and extracted according to predefined PICO criteria. RESULTS: Fourteen studies fulfilled the inclusion criteria (four pediatric clinical cohorts, ten direct preclinical murine or in vitro studies). Across murine models, keratinocyte-derived IL-33 consistently activated a skin-to-gut axis driving intestinal mast-cell expansion and IgE-independent food anaphylaxis, which was abrogated by genetic or pharmacologic ST2 blockade. In a small case-control study of nine children with eosinophilic gastroenteritis, serum IL-33 and TSLP were increased during active disease and declined after dietary elimination. In pediatric eosinophilic esophagitis, IL-33 was increased in tissue but not consistently in serum. Conversely, serum IL-33 demonstrated limited discriminatory value in IgE-mediated food allergy. CONCLUSIONS: IL-33 emerges as a context-dependent yet non-redundant component of the epithelial alarmin circuitry in pediatric food-related allergic disease, as candidate biomarker of epithelial inflammation in pediatric EGIDs. However, current clinical evidence is limited and requires validation in larger prospective cohorts. CI - Copyright (c) 2026 Grama, Sasaran, Stan Muntean, Coman, Ivasko and Marginean. FAU - Grama, Monica AU - Grama M AD - Doctoral School, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Targu Mures, Romania. AD - Pediatric Clinic I, County Emergency Hospital of Targu Mures, Targu Mures, Romania. FAU - Sasaran, Maria Oana AU - Sasaran MO AD - Department of Pediatrics 3, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, Romania. FAU - Stan Muntean, Ana AU - Stan Muntean A AD - Doctoral School, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Targu Mures, Romania. FAU - Coman, Delia AU - Coman D AD - Doctoral School, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Targu Mures, Romania. AD - Pediatric Clinic I, County Emergency Hospital of Targu Mures, Targu Mures, Romania. FAU - Ivasko, Alina AU - Ivasko A AD - Doctoral School, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Targu Mures, Romania. AD - Department of Internal Medicine, County Emergency Hospital of Targu Mures, Targu Mures, Romania. FAU - Marginean, Cristina Oana AU - Marginean CO AD - Department of Pediatrics 1, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, Romania. LA - eng PT - Journal Article PT - Systematic Review DEP - 20261012 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Interleukin-33) RN - 0 (Interleukin-1 Receptor-Like 1 Protein) RN - 0 (IL1RL1 protein, human) RN - 0 (IL33 protein, human) RN - 0 (Biomarkers) RN - Eosinophilic enteropathy SB - IM MH - Humans MH - *Interleukin-33/metabolism/immunology MH - *Food Hypersensitivity/immunology/metabolism MH - *Interleukin-1 Receptor-Like 1 Protein/metabolism/immunology MH - Child MH - Animals MH - Signal Transduction MH - *Enteritis/immunology/metabolism MH - *Eosinophilia/immunology/metabolism MH - Biomarkers/metabolism MH - Gastritis PMC - PMC13696261 OTO - NOTNLM OT - TSLP OT - alarmin triad OT - food allergies OT - interleukin 25 OT - interleukin 33 OT - pediatric patients COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/27 16:33 MHDA- 2026/10/27 16:34 PMCR- 2026/10/12 CRDT- 2026/10/27 05:48 PHST- 2026/08/07 00:00 [received] PHST- 2026/09/20 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/27 16:34 [medline] PHST- 2026/10/27 16:33 [pubmed] PHST- 2026/10/27 05:48 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1961426 [doi] PST - epublish SO - Front Immunol. 2026 Oct 12;17:1961426. doi: 10.3389/fimmu.2026.1961426. eCollection 2026. PMID- 42934752 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2662-2211 (Electronic) IS - 2662-2211 (Linking) VI - 7 IP - 1 DP - 2026 Jul 30 TI - Barriers and enablers to the integration of family planning, immunization, and nutrition services into RMNCAH-N services in primary health care settings in Ethiopia. LID - 10.1186/s43058-026-01042-6 [doi] LID - 214 AB - BACKGROUND: Despite national policies promoting integrated Family Planning, Immunization, and Nutrition services, implementation remains challenging in Ethiopia's diverse primary healthcare settings. This research aimed to identify the barriers and enablers of integrating family planning, immunization, and nutrition services into reproductive, maternal, newborn, child, and adolescent health and nutrition (RMNCAH-N) services in selected agrarian and pastoralist regions of Ethiopia. METHODS: A qualitative case study was conducted in ten primary healthcare units located across three districts: one district in pastoralist Afar region and two districts in the agrarian regions of Oromia and Central Ethiopia. We conducted seven focus group discussions (FGDs), 18 In-depth interviews (IDIs), and 10 key informant interviews (KIIs) with a total of 91 participants selected purposively, including program managers and policy-makers, health workers, and clients. Data were analyzed using a combined deductive and inductive approach guided by the Consolidated Framework for Implementation Research Version 2.0 (CFIR 2.0). RESULTS: 17 of 48 CFIR 2.0 constructs were identified as influencing the integration of Family Planning, Immunization, and Nutrition services into RMNCAH-N touchpoints. Key barriers included: within the inner setting (inadequate facility readiness and limited space, essential supply shortages, poor provider commitment, and negative provider perceptions towards service integration), the outer setting (rural residence and political instability), and individuals and sociocultural factors (male-dominance in healthcare decision-making and restrictive cultural and religious norms particularly in pastoralist communities). Key enablers included: the innovation relative advantage of integration (reduced missed opportunities, lower transportation costs, fewer facility visits, and time savings), supportive inner setting factors such as enhanced teamwork, and improved health-seeking behavior facilitated by integrated health communication. CONCLUSION: Integration of Family Planning, Immunization, and Nutrition services into RMNCAH-N services is influenced by distinct contextual factors in agrarian and pastoralist settings. To enhance integration, we recommend: improving facility readiness (space and supplies), addressing sociocultural barriers through community engagement, including male involvement, particularly in pastoralist areas, ensuring supply chain reliability, and providing performance-based incentives and continuous professional development to mitigate provider burnout and sustain quality integrated care. CI - (c) 2026. The Author(s). FAU - Sadamo, Fekadu Elias AU - Sadamo FE AUID- ORCID: 0000-0002-7987-7897 AD - School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia. eliasfekadu16@gmail.com. AD - Medical Education Center, Soddo Christian Hospital, Wolaita Sodo, Ethiopia. eliasfekadu16@gmail.com. FAU - Adinew, Yohannes Mehretie AU - Adinew YM AD - EngenderHealth, Addis Ababa, Ethiopia. FAU - Dake, Samson Kastro AU - Dake SK AD - School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia. FAU - Asegdom, Yordanos Sisay AU - Asegdom YS AD - School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia. AD - School of Nursing and Midwifery, Edith Cowan University, Perth, Western Australia, Australia. FAU - Asnake, Angwach Abraham AU - Asnake AA AD - School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia. FAU - Enkubahir, Siyoum AU - Enkubahir S AD - EngenderHealth, Addis Ababa, Ethiopia. FAU - Bayou, Yibeltal AU - Bayou Y AD - EngenderHealth, Addis Ababa, Ethiopia. FAU - Emaway, Dessalew AU - Emaway D AD - John Snow Research & Training Institute Inc, Addis Ababa, Ethiopia. FAU - Mohammed, Jemal Kassaw AU - Mohammed JK AD - EngenderHealth, Addis Ababa, Ethiopia. FAU - O'Connell, Kathryn A AU - O'Connell KA AD - EngenderHealth, Washington, DC, USA. FAU - Tiruneh, Gizachew Tadele AU - Tiruneh GT AD - John Snow Research & Training Institute Inc, Addis Ababa, Ethiopia. AD - University of Global Health Equity, Kigali, Rwanda. AD - Addis Continental Institute of Public Health, Addis Ababa, Ethiopia. FAU - Meskele, Mengistu AU - Meskele M AD - School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia. LA - eng GR - EngenderHealth agreement: PSE 028/2024; Award number: CFS010./JSI RESEARCH & TRAINING INSTITUTE has funded this research. JSI also processed the funding with the collaboration of EngenderHealth as part of the Strengthening Service Delivery (SSD) Project./ PT - Journal Article DEP - 20260730 PL - England TA - Implement Sci Commun JT - Implementation science communications JID - 101764360 PMC - PMC13712089 OTO - NOTNLM OT - Barriers OT - Enablers OT - Ethiopia OT - Implementation research OT - RMNCAH-N OT - Service integration COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/27 05:29 MHDA- 2026/10/27 05:30 PMCR- 2026/07/30 CRDT- 2026/10/27 00:47 PHST- 2025/11/26 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/10/27 05:30 [medline] PHST- 2026/10/27 05:29 [pubmed] PHST- 2026/10/27 00:47 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - 10.1186/s43058-026-01042-6 [pii] AID - 1042 [pii] AID - 10.1186/s43058-026-01042-6 [doi] PST - epublish SO - Implement Sci Commun. 2026 Jul 30;7(1):214. doi: 10.1186/s43058-026-01042-6. PMID- 42934590 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 29 TI - The association between perceived bullying in physical education classes and school satisfaction among middle school students: the mediating roles of physical activity enjoyment and physical education class happiness. LID - 10.1186/s12887-026-07376-3 [doi] LID - 1064 AB - BACKGROUND: Bullying is an important child and adolescent health concern associated with psychosocial adjustment, school well-being, and school satisfaction. Physical education (PE) classes may represent a particularly sensitive context because they involve body visibility, peer comparison, physical performance, and intensive peer interaction. This study examined the association between perceived bullying in PE classes and school satisfaction among middle school students and tested whether physical activity enjoyment and PE class happiness statistically mediated this association. METHODS: This cross-sectional correlational study included 616 middle school students from Malatya, Turkiye. Data were collected using validated measures of perceived bullying in PE classes, physical activity enjoyment, PE class happiness, and school satisfaction. A four-factor latent measurement model and the hypothesized structural mediation model were estimated using robust maximum likelihood. Measurement validity and reliability were evaluated using confirmatory factor analysis, composite reliability, average variance extracted, and the heterotrait-monotrait ratio. RESULTS: The four-factor measurement model demonstrated acceptable fit to the data (chi(2)/df = 2.22, CFI = 0.922, TLI = 0.916, RMSEA = 0.045, SRMR = 0.044), and HTMT values supported discriminant validity. Perceived bullying in PE classes was negatively associated with physical activity enjoyment (beta = -0.157, p < .001), PE class happiness (beta = -0.181, p < .001), and school satisfaction (beta = -0.096, p = .042). Physical activity enjoyment (beta = 0.237, p < .001) and PE class happiness (beta = 0.201, p < .001) were positively associated with school satisfaction. Both indirect associations were statistically significant but small in magnitude (beta = -0.037, p = .006; beta = -0.036, p = .010), and the direct association between perceived bullying and school satisfaction was also small (beta = -0.096, p = .042). The model explained 16.9% of the variance in school satisfaction, whereas perceived bullying explained 2.3% and 3.1% of the variance in physical activity enjoyment and PE class happiness, respectively, indicating modest practical explanatory power. CONCLUSIONS: Perceived bullying in PE classes was associated with lower school satisfaction both directly and indirectly through lower physical activity enjoyment and lower PE class happiness. However, these associations were modest and should not be interpreted as causal because of the cross-sectional design. The findings support efforts to promote psychologically safe and inclusive PE environments as part of school health and bullying prevention strategies. CI - (c) 2026. The Author(s). FAU - Gullu, Mehmet AU - Gullu M AUID- ORCID: 0000-0002-0930-7178 AD - Inonu University, Malatya, Turkiye, Turkey. mehmet.gullu@inonu.edu.tr. AD - Faculty of Sport Sciences, Department of Physical Education and Sports Teaching, Inonu University, Malatya, Turkiye, Turkey. mehmet.gullu@inonu.edu.tr. FAU - Akarsu, Mehmet AU - Akarsu M AUID- ORCID: 0000-0002-8149-801X AD - Inonu University, Malatya, Turkiye, Turkey. FAU - Tan, Hasret AU - Tan H AUID- ORCID: 0009-0003-3864-3087 AD - Inonu University, Malatya, Turkiye, Turkey. FAU - Karakas, Ecesu AU - Karakas E AUID- ORCID: 0000-0002-2324-365X AD - Munzur University, Tunceli, Turkiye, Turkey. FAU - Gunata, Gul Polat AU - Gunata GP AUID- ORCID: 0000-0002-6744-6440 AD - Malatya Turgut Ozal University, Malatya, Turkiye, Turkey. FAU - Akcinar, Serpil AU - Akcinar S AUID- ORCID: 0000-0001-9454-0582 AD - Inonu University, Malatya, Turkiye, Turkey. LA - eng GR - SBA-2026-4820/Inonu Universitesi/ PT - Journal Article DEP - 20260729 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Bullying/psychology MH - Cross-Sectional Studies MH - *Happiness MH - *Physical Education and Training MH - Female MH - Male MH - Adolescent MH - *Personal Satisfaction MH - *Exercise/psychology MH - *Students/psychology MH - Child MH - Schools MH - Reproducibility of Results PMC - PMC13712069 OTO - NOTNLM OT - Peer bullying OT - Physical activity enjoyment OT - Physical education OT - Physical education class happiness OT - School satisfaction COIS- Declarations. Ethics approval and consent to participate: This study received ethical approval by the decision of Inonu University Social and Human Sciences Scientific Research and Publication Ethics Committee dated November 20, 2025, and numbered 32. In addition, written informed consent was obtained from each school and each student's parent or legal guardian before data collection. All methods were performed in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/27 05:29 MHDA- 2026/10/27 05:30 PMCR- 2026/07/29 CRDT- 2026/10/27 00:38 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/10/27 05:30 [medline] PHST- 2026/10/27 05:29 [pubmed] PHST- 2026/10/27 00:38 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1186/s12887-026-07376-3 [pii] AID - 7376 [pii] AID - 10.1186/s12887-026-07376-3 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 29;26(1):1064. doi: 10.1186/s12887-026-07376-3. PMID- 42934038 OWN - NLM STAT- Publisher LR - 20261026 IS - 1436-2023 (Electronic) IS - 0949-2658 (Linking) DP - 2026 Oct 26 TI - The illusion of continued leg growth: A modern 3D anthropometric analysis of segmental growth dissociation in Korean children. LID - S0949-2658(26)00299-X [pii] LID - 10.1016/j.jos.2026.09.017 [doi] AB - AIMS: The classical Anderson-Green model, which posits that male lower limb growth continues until age 17, often leads to overestimation of residual growth and subsequent overcorrection. We aimed to establish a modern, population-specific growth model for contemporary Korean children using 3D whole-body scanning. Through this comprehensive mapping, we investigated the physiological discrepancy and temporal dissociation between spinal and lower limb growth. METHODS: High-resolution 3D automated anthropometric data from a large-scale national database (Size Korea; 1110 subjects aged 7-19 years) were analysed. Segmental growth trajectories were precisely isolated using standardized skeletal landmarks (knee and hip heights) and modelled via Monotonic Smoothing. A linear growth hypothesis for individual growth plates-validated through simulation analysis-was integrated into an interactive web application for adaptive residual growth prediction. RESULTS: Significant temporal dissociation was observed between spinal and lower limb growth. In males, lower limb growth plateaued at age 14.5-15.5, while standing height continued to increase until age 17.5-18.5. This 3-year discrepancy was driven exclusively by spinal growth continuing after lower extremity plate closure. Females showed a similar 2-year gap, with limb growth ceasing at age 12.5-13.5 and spinal growth at 14.5-15.5. CONCLUSIONS: The traditional "17-year rule" is a clinical illusion driven by late-adolescent spinal elongation. Modelling individual bone growth as a simple linear trajectory provides an intuitive, highly practical alternative that maintains predictive accuracy while minimizing clinical user error. These modernized, segment-specific references, combined with the customizable web interface, offer an evidence-based framework for optimizing the timing of leg-length discrepancy correction. CI - Copyright (c) 2026 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved. FAU - Kim, Jeehyoung AU - Kim J AD - Department of Orthopaedic Surgery, Seoul Sacred Heart General Hospital, Seoul, Republic of Korea. FAU - Park, Joonsung AU - Park J AD - Department of Orthopaedic Surgery, Seoul Sacred Heart General Hospital, Seoul, Republic of Korea. FAU - Kim, Yerang AU - Kim Y AD - Department of Convergence Software, Applied Software Major, Myongji University, Seoul, Republic of Korea. FAU - Choi, Euntaek AU - Choi E AD - Department of Convergence Software, Data Science Major, Myongji University, Seoul, Republic of Korea. FAU - Kim, Young Kook AU - Kim YK AD - Department of Orthopaedic Surgery, Seoul Sacred Heart General Hospital, Seoul, Republic of Korea. Electronic address: clipom63@gmail.com. LA - eng PT - Journal Article DEP - 20261026 PL - Japan TA - J Orthop Sci JT - Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association JID - 9604934 SB - IM OTO - NOTNLM OT - 3D anthropometry OT - Epiphysiodesis OT - Growth plate OT - Korean population OT - Leg length discrepancy (LLD) OT - Monotonic smoothing OT - Residual growth prediction COIS- Conflict of interest The authors declare no competing interests. EDAT- 2026/10/26 23:27 MHDA- 2026/10/26 23:27 CRDT- 2026/10/26 22:58 PHST- 2026/07/16 00:00 [received] PHST- 2026/09/13 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/26 23:27 [medline] PHST- 2026/10/26 23:27 [pubmed] PHST- 2026/10/26 22:58 [entrez] AID - S0949-2658(26)00299-X [pii] AID - 10.1016/j.jos.2026.09.017 [doi] PST - aheadofprint SO - J Orthop Sci. 2026 Oct 26:S0949-2658(26)00299-X. doi: 10.1016/j.jos.2026.09.017. PMID- 42934008 OWN - NLM STAT- Publisher LR - 20261026 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) DP - 2026 Oct 26 TI - Identification of metabolic risk phenotypes among U.S. adolescents: A machine learning analysis of NHANES 2017-2023. LID - S0882-5963(26)00529-4 [pii] LID - 10.1016/j.pedn.2026.10.021 [doi] AB - BACKGROUND: Adolescent metabolic risk is multidimensional and may not be fully characterized by individual anthropometric or biochemical indicators considered separately; however, evidence regarding data-derived metabolic-risk phenotypes among adolescents remains limited. PURPOSE: To identify metabolic risk phenotypes among U.S. adolescents using unsupervised machine learning and examine demographic and socioeconomic factors associated with phenotype membership. METHODS: Data from adolescents aged 12-17 years participating in the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020 and 2021-2023 cycles were analyzed. K-means clustering was performed among 848 adolescents with complete data for seven anthropometric and cardiometabolic variables. Logistic regression examined sociodemographic factors associated with elevated metabolic-risk phenotype membership. RESULTS: A two-cluster solution yielded the highest silhouette coefficient (0.289), identifying a lower metabolic-risk phenotype (n = 580, 68.4%) and an elevated metabolic-risk phenotype (n = 268, 31.6%). The elevated-risk phenotype was characterized by substantially higher BMI and waist circumference, together with higher triglycerides and LDL-C cholesterol, lower HDLC, and modestly higher glycated hemoglobin. In the adjusted logistic regression analysis (n = 763), older age was associated with greater odds of elevated-risk phenotype membership (aOR = 1.18, 95% CI 1.07-1.29), whereas income-to-poverty ratio was associated with lower odds (aOR = 0.78, 95% CI 0.70-0.87). CONCLUSIONS: Unsupervised machine learning identified two exploratory metabolic-risk phenotypes characterized by concurrent differences in adiposity, lipid, and glycemic measures. The findings provide an exploratory basis for investigating multidimensional cardiometabolic assessment approaches relevant to pediatric nursing. Independent replication and longitudinal validation are needed to determine their prognostic and clinical utility. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Antunez Martinez, Oscar Fidel AU - Antunez Martinez OF AD - School of Nursing, National Taipei University of Nursing and Health Sciences, No. 365, Mingde Rd. Beitou District, Taipei, 11219, Taiwan, ROC. Electronic address: oscarfidelantunez@gmail.com. LA - eng PT - Journal Article DEP - 20261026 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM OTO - NOTNLM OT - Adolescent OT - Pediatric metabolic syndrome OT - Pediatric nursing OT - United States OT - Unsupervised machine learning COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/26 23:27 MHDA- 2026/10/26 23:27 CRDT- 2026/10/26 22:56 PHST- 2026/06/18 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/10/15 00:00 [accepted] PHST- 2026/10/26 23:27 [medline] PHST- 2026/10/26 23:27 [pubmed] PHST- 2026/10/26 22:56 [entrez] AID - S0882-5963(26)00529-4 [pii] AID - 10.1016/j.pedn.2026.10.021 [doi] PST - aheadofprint SO - J Pediatr Nurs. 2026 Oct 26:S0882-5963(26)00529-4. doi: 10.1016/j.pedn.2026.10.021. PMID- 42933812 OWN - NLM STAT- In-Process LR - 20261028 IS - 2052-4439 (Electronic) IS - 2052-4439 (Linking) VI - 13 IP - 1 DP - 2026 Oct 26 TI - Home video sleep recording as a predictor of polysomnography-diagnosed obstructive sleep apnoea in a developmentally normal paediatric population. LID - 10.1136/bmjresp-2026-004187 [doi] LID - e004187 AB - BACKGROUND: Polysomnography (PSG) is the gold standard investigation for paediatric obstructive sleep apnoea (OSA) but has limitations. Sleep videos are a promising screening alternative. OBJECTIVES: This study explores the use of a short, home-based video sleep recording captured shortly after sleep onset as a simple and readily available screening modality for OSA. METHODS: Children (aged 1-18 years) undergoing PSG at a tertiary hospital to investigate OSA symptoms were consecutively recruited. OSA was defined as an obstructive apnoea hypopnoea index >1 episode/h on PSG. Videos (>/=5 min) of the head and exposed torso were captured at home. Snore, type of inspiratory noise, respiratory events, respiratory effort, mouth breathing and neck extension were scored using a modified scoring system. The Sleep Disturbance Scale for Children (SDSC) was completed. Sleep video scores were then combined with brief demographic and anthropometric data and SDSC results using logistic regression to develop an OSA screening model. RESULTS: 194 children were recruited, and 91 technically satisfactory videos were returned (29F; mean (SD) age 8.9 (3.0) years; median (IQR) body mass index (BMI) z-score 1.1 (0.3-2.1)). 26 (28.6%) children had OSA on PSG. Total video score >/=1 predicted OSA with sensitivity 80.8%, specificity 67.2% and area under the receiver operating characteristic curve (AUC) 0.74. A multivariate logistic regression model incorporating total video score, BMI z-score and SDSC subscale score predicted OSA with sensitivity 94.4%, negative predictive value 96.9% and AUC 0.89. CONCLUSIONS: We have found a single, short sleep video captured at a time convenient for the parent/caregiver to be a promising, simple and inexpensive screening modality for paediatric OSA. The addition of easily obtained demographic, anthropometric and questionnaire-based items resulted in a high sensitivity, supporting ongoing investigation of this modality and its utility in streamlining PSG access for those at highest risk of OSA while allowing lower-risk children to follow a watch-and-wait approach. FAU - Daniels, Celeste AU - Daniels C AUID- ORCID: 0000-0001-7919-4511 AD - Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia celeste.daniels@uqconnect.edu.au. AD - Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. FAU - Kapur, Nitin AU - Kapur N AD - Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia. AD - Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. FAU - Ware, Robert S AU - Ware RS AD - Griffith Biostatistics Unit, Griffith University, Brisbane, Queensland, Australia. AD - Wesley Research Institute, Brisbane, Queensland, Australia. FAU - Gauld, Leanne AU - Gauld L AUID- ORCID: 0000-0003-0819-894X AD - Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia. AD - Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. LA - eng PT - Journal Article DEP - 20261026 PL - England TA - BMJ Open Respir Res JT - BMJ open respiratory research JID - 101638061 SB - IM PMC - PMC13711606 OTO - NOTNLM OT - Sleep apnoea EDAT- 2026/10/26 23:27 MHDA- 2026/10/26 23:27 PMCR- 2026/10/26 CRDT- 2026/10/26 20:53 PHST- 2026/02/15 00:00 [received] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/26 23:27 [medline] PHST- 2026/10/26 23:27 [pubmed] PHST- 2026/10/26 20:53 [entrez] PHST- 2026/10/26 00:00 [pmc-release] AID - 13/1/e004187 [pii] AID - bmjresp-2026-004187 [pii] AID - 10.1136/bmjresp-2026-004187 [doi] PST - epublish SO - BMJ Open Respir Res. 2026 Oct 26;13(1):e004187. doi: 10.1136/bmjresp-2026-004187. PMID- 42933650 OWN - NLM STAT- Publisher LR - 20261026 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) DP - 2026 Oct 26 TI - Correction-free quantification of retinol in dried blood spots from children: agreement with plasma concentrations and plasma-based classification of vitamin A inadequacy. PG - 101908 LID - S0022-3166(26)00557-2 [pii] LID - 10.1016/j.tjnut.2026.101908 [doi] AB - BACKGROUND: Vitamin A (VA) inadequacy (VAI) remains prevalent among Chinese children, but venous sampling for plasma retinol can constrain large-scale monitoring. Dried blood spot (DBS) sampling is minimally invasive, although many existing methods rely on population-specific correction factors. A previously described serum-based calibration approach offers correction-free quantification, but its performance across the pediatric hematocrit (HCT) range requires evaluation. OBJECTIVE: To evaluate correction-free DBS retinol measurement against paired plasma retinol in children, assessing agreement, plasma-based VAI classification, HCT associations, and interlaboratory reproducibility. METHODS: Paired plasma and DBS samples from 85 children younger than 9 y (20 aged <6 mo) were analyzed. Agreement was assessed using the intraclass correlation coefficient (ICC), overlap coefficient (OVL), Passing-Bablok regression, and Bland-Altman analysis. VAI classification was compared using cutoffs of 1.05 mumol/L for children aged >/=6 mo and an exploratory cutoff of 0.489 mumol/L for infants aged <6 mo. The WHO deficiency cutoff of 0.70 mumol/L was evaluated as a secondary threshold. HCT associations and three-site reproducibility (23 samples) were assessed. RESULTS: DBS and plasma retinol showed high agreement (ICC 0.918; OVL 0.939). Mean bias was +0.035 mumol/L (95% limits of agreement: -0.388 to +0.458). Passing-Bablok analysis detected no significant constant or proportional bias. DBS reproduced plasma-based VAI classification with 92.9% accuracy (Youden's J 0.862; sensitivity 93.3%; specificity 92.9%). HCT was inversely associated with the DBS-plasma difference (rho = -0.242, P = 0.026), with absolute mean biases across HCT categories /=10, and protection against rCpDPP1-induced E-cadherin loss. In vivo, high-dose hypocrellin A and fluazinam reduced fecal oocyst shedding on day 3 of treatment by approximately 95.83% and 97.57%, respectively, in the chronic C. tyzzeri infection model, and on day 7 post-infection by approximately 55.39% and 52.94%, respectively, in the IFN-gamma-KO C. parvum infection model, compared with vehicle controls. Treatment also reduced intestinal parasite burden, attenuated weight loss, improved survival, and ameliorated intestinal pathology. These findings identify CpDPP1 as a secreted host-interface protease linked to early infection-associated epithelial damage and support CpDPP1-directed screening as a strategy for anti-cryptosporidial inhibitor discovery. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Jiang, Peng AU - Jiang P AD - State Key Laboratory for the Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China. FAU - Yin, Jigang AU - Yin J AD - State Key Laboratory for the Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China. FAU - Chen, Tao AU - Chen T AD - State Key Laboratory for the Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China. FAU - Xu, Bingjie AU - Xu B AD - State Key Laboratory for the Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China. FAU - Kou, Congying AU - Kou C AD - State Key Laboratory for the Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China. FAU - Zhu, Guan AU - Zhu G AD - State Key Laboratory for the Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China. Electronic address: cryptosporida@gmail.com. FAU - Wang, Dongqiang AU - Wang D AD - State Key Laboratory for the Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China. Electronic address: wdq909@jlu.edu.cn. LA - eng PT - Journal Article DEP - 20261023 PL - Netherlands TA - Int J Parasitol Drugs Drug Resist JT - International journal for parasitology. Drugs and drug resistance JID - 101576715 SB - IM OTO - NOTNLM OT - Anti-cryptosporidial efficacy OT - Cryptosporidium parvum OT - Dipeptidyl peptidase OT - E-cadherin OT - Epithelial barrier disruption OT - High-throughput screening (HTS) OT - Inhibitors COIS- Conflict of iInterest The authors confirm that there are no known financial or personal conflicts of interest that could have affected the work presented in this paper. EDAT- 2026/10/26 23:27 MHDA- 2026/10/26 23:27 CRDT- 2026/10/26 19:11 PHST- 2026/05/27 00:00 [received] PHST- 2026/09/29 00:00 [revised] PHST- 2026/10/19 00:00 [accepted] PHST- 2026/10/26 23:27 [medline] PHST- 2026/10/26 23:27 [pubmed] PHST- 2026/10/26 19:11 [entrez] AID - S2211-3207(26)00044-8 [pii] AID - 10.1016/j.ijpddr.2026.100674 [doi] PST - aheadofprint SO - Int J Parasitol Drugs Drug Resist. 2026 Oct 23;32:100674. doi: 10.1016/j.ijpddr.2026.100674. PMID- 42933194 OWN - NLM STAT- Publisher LR - 20261026 IS - 1873-6947 (Electronic) IS - 1744-3881 (Linking) VI - 65 DP - 2026 Oct 24 TI - Feasibility and acceptability of Ballet for All Kids: A pilot study of a recreational ballet program for children with autism. PG - 102091 LID - S1744-3881(26)00049-6 [pii] LID - 10.1016/j.ctcp.2026.102091 [doi] AB - BACKGROUND AND PURPOSE: Motor impairments are common in children with autism yet targeted interventions are under-studied. Studies have highlighted the potential of dance to be a therapeutic adjunct, but research is limited. We conducted a randomized controlled trial to assess the feasibility and acceptability of Ballet for all Kids (BFAK), a recreational ballet program employing the Schlachte Method, a multi-sensory framework that makes classes accessible to learners with autism. Secondary aims included exploring efficacy in improving balance and behaviors. MATERIALS AND METHODS: A total of 24 participants (68% female) were recruited and randomized to a waitlist control or experimental group with 1:1 assignment. Both groups received BFAK classes for 45 min weekly for 12 weeks. Feasibility metrics (retention, attendance, survey completion) were collected. Motor and behavioral outcomes were assessed using validated caregiver-reports and in-class assessments. RESULTS: BFAK demonstrated excellent feasibility and acceptability with a 79% (n = 19) participant completion rate, high attendance (mean = 10.1 classes), high survey response rates (mean = 88%), and significant improvements in participation (r = 0.706, p = 0.002). Outcome analyses showed modest improvements in balance (r = 0.397, p = 0.083). The experimental group had fewer repetitive behaviors than the control group (RBS-R, BH-adjusted p = 0.047, r = 0.756). CONCLUSION: The high retention, attendance, survey completion rates, and engagement demonstrate that BFAK is feasible and acceptable for children with autism. Findings further suggest potential benefits in balance and repetitive behaviors. Limitations include a small sample size and reliance on caregiver-reports. Nevertheless, results support the need for larger studies to test efficacy and generalizability. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Alon, Noy AU - Alon N AD - Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Noy.alon@icahn.mssm.edu. FAU - Adler, Michelle J AU - Adler MJ AD - Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Michelle.adler@icahn.mssm.edu. FAU - Vicioso, Camila AU - Vicioso C AD - Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Camila.vicioso@icahn.mssm.edu. FAU - Freilich, Annabelle Elikan AU - Freilich AE AD - Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Eliana.Elikan@icahn.msms.edu. FAU - Badawi, Alia AU - Badawi A AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Alia.Badawi@mountsinai.org. FAU - Schlachte, Bonnie AU - Schlachte B AD - Ballet for All Kids, Los Angeles, CA, USA. Electronic address: bonnie@balletforallkids.com. FAU - Ranade, Sheena C AU - Ranade SC AD - Department of Orthopedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Sheena.Ranade@mountsinai.org. FAU - Kolevzon, Alexander AU - Kolevzon A AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: Alexander.kolevzon@mssm.edu. LA - eng PT - Journal Article DEP - 20261024 PL - England TA - Complement Ther Clin Pract JT - Complementary therapies in clinical practice JID - 101225531 SB - IM OTO - NOTNLM OT - Autism spectrum disorder OT - Community health services OT - Dancing OT - Exercise OT - Motor skills COIS- Conflict of interest disclosure BS is the Current and Founding Director of Ballet For All Kids. AK is on the Advisory Board for the Klingenstein Third Generation Foundation, David Lynch Foundation, and ADNP Kids Research Foundation, and consults to Neuren Pharmaceuticals, PYC Therapeutics, and Clinilabs Drug Development Corporation. All other authors have no conflicts of interest to disclose. EDAT- 2026/10/26 23:27 MHDA- 2026/10/26 23:27 CRDT- 2026/10/26 19:06 PHST- 2025/12/23 00:00 [received] PHST- 2026/10/16 00:00 [revised] PHST- 2026/10/16 00:00 [accepted] PHST- 2026/10/26 23:27 [medline] PHST- 2026/10/26 23:27 [pubmed] PHST- 2026/10/26 19:06 [entrez] AID - S1744-3881(26)00049-6 [pii] AID - 10.1016/j.ctcp.2026.102091 [doi] PST - aheadofprint SO - Complement Ther Clin Pract. 2026 Oct 24;65:102091. doi: 10.1016/j.ctcp.2026.102091. PMID- 42931834 OWN - NLM STAT- Publisher LR - 20261026 IS - 1434-4726 (Electronic) IS - 0937-4477 (Linking) DP - 2026 Oct 26 TI - Global practices in paediatric olfactory dysfunction: a cross-sectional survey of paediatric ENT surgeons. LID - 10.1007/s00405-026-10668-0 [doi] AB - BACKGROUND: Olfactory dysfunction (OD) in children remains underdiagnosed and poorly characterised. Despite its known impacts on nutrition, quality of life, safety awareness, and psychosocial development, no standardised diagnostic or management pathway currently exists for paediatric OD. This study aimed to characterise global practice patterns and identify diagnostic and therapeutic challenges unique to paediatric care. METHODOLOGY/PRINCIPAL: A 44-item cross-sectional online survey was distributed to a verified international network of paediatric otolaryngologists across 36 countries via a closed professional platform. The survey assessed five domains: diagnostic practices, management protocols, technology and innovation, education and training, and barriers to effective care. Regional grouping was used to facilitate meaningful statistical comparisons. Categorical variables were evaluated using chi-square tests, with odds ratios and 95% confidence intervals reported for significant findings. RESULTS: Of 351 potential participants, 167 responded (47.6% response rate). Most respondents (83%) reported seeing children with OD, yet 95% saw fewer than ten such patients annually. Psychophysical testing was never performed by 54.8% of respondents, while 88.4% routinely ordered cross-sectional imaging. Testing frequency increased significantly with patient age (Cochran's Q p < .001). The most common barriers to objective testing were insufficient training (44.3%), time constraints (29.9%), and funding limitations (28.1%). Multidisciplinary collaboration was negligible. Significant regional variation was observed across most practice domains. CONCLUSIONS: Paediatric OD care is characterised by functional underinvestigation, fragmented multidisciplinary collaboration, and systemic educational gaps. These findings support urgent development of standardised clinical guidelines, age-appropriate validated assessment tools, and formal interdisciplinary care pathways. CI - (c) 2026. The Author(s). FAU - Spencer, Gina M AU - Spencer GM AUID- ORCID: 0009-0002-6783-5574 AD - Queen's University School of Medicine, 80 Barrie Street, Kingston, Ontario, K7L 3N6, Canada. gspencer@qmed.ca. AD - Division of Otolaryngology, Dalhousie University, Halifax, Nova Scotia, Canada. gspencer@qmed.ca. FAU - Karim, Kunwar AU - Karim K AD - Queen's University School of Medicine, 80 Barrie Street, Kingston, Ontario, K7L 3N6, Canada. FAU - Dzioba, Agnieszka AU - Dzioba A AD - Schulich School of Medicine, Western University, Ontario, London, Canada. AD - Department of Otolaryngology-Head & Neck Surgery, Children's Hospital, London Health Sciences Centre, London, Ontario, Canada. FAU - Graham, Elise M AU - Graham EM AD - Division of Otolaryngology, Dalhousie University, Halifax, Nova Scotia, Canada. FAU - You, Peng AU - You P AD - Schulich School of Medicine, Western University, Ontario, London, Canada. AD - Department of Otolaryngology-Head & Neck Surgery, Children's Hospital, London Health Sciences Centre, London, Ontario, Canada. FAU - Hummel, Thomas AU - Hummel T AD - Interdisciplinary Centre Smell & Taste, Universitatsklinikum Carl Gustav Carus, Dresden, Germany. FAU - Gellrich, Janine AU - Gellrich J AD - Abteilung Neuropadiatrie, Department of Pediatrics, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany. FAU - Coyle, Paula AU - Coyle P AD - Department of Otolaryngology, Royal National ENT and Eastman Dental Hospitals, University College London Hospitals NHS Foundation Trust, London, UK. FAU - Burns, Hannah AU - Burns H AD - Department of Otolaryngology, Queensland Children's Hospital, Brisbane, Australia. AD - University of Queensland, Brisbane, QLD, Australia. FAU - Peer, Shazia AU - Peer S AD - Department of Otolaryngology, University of Cape Town, Groote Schuur & Red Cross War Memorial Children's Hospitals, Cape Town, South Africa. FAU - Zawawi, Faisal AU - Zawawi F AD - Department of Otolaryngology, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Lechien, Jerome R AU - Lechien JR AD - Department of Otolaryngology-Head Neck Surgery, University Hospital of Brussels, Brussels, Belgium. FAU - Schriever, Valentin A AU - Schriever VA AD - Department of Pediatrics, Division of Pediatric Neurology, Neurometabolics and Prevention, Goethe University Frankfurt, Frankfurt (Main), Germany. FAU - Bhargava, Eishaan K AU - Bhargava EK AD - Department of Otolaryngology, Sheffield Children's Hospital, Sheffield, UK. e.k.bhargava@sheffield.ac.uk. AD - Faculty of Health, University of Sheffield, Sheffield, UK. e.k.bhargava@sheffield.ac.uk. FAU - Whitcroft, Katherine L AU - Whitcroft KL AD - Department of Otolaryngology, Sheffield Children's Hospital, Sheffield, UK. LA - eng PT - Journal Article DEP - 20261026 PL - Germany TA - Eur Arch Otorhinolaryngol JT - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JID - 9002937 SB - IM OTO - NOTNLM OT - Child OT - Clinical practice patterns OT - Olfaction disorders OT - Otolaryngology OT - Surveys and questionnaires COIS- Declarations. Informed consent: Written informed consent was received from all human participants prior to participation in our survey study. Conflicts of interest: No conflicts of interest to declare. Employment: No conflicts of employment to declare. EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:31 CRDT- 2026/10/26 12:04 PHST- 2026/05/08 00:00 [received] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/26 17:31 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 12:04 [entrez] AID - 10.1007/s00405-026-10668-0 [pii] AID - 10.1007/s00405-026-10668-0 [doi] PST - aheadofprint SO - Eur Arch Otorhinolaryngol. 2026 Oct 26. doi: 10.1007/s00405-026-10668-0. PMID- 42931743 OWN - NLM STAT- Publisher LR - 20261026 IS - 1528-1132 (Electronic) IS - 0009-921X (Linking) DP - 2026 Oct 26 TI - Does Inspiratory Lung Volume Help Explain the Association Between Thoracic Deformity and Pulmonary Dysfunction in Adolescent Idiopathic Scoliosis? LID - 10.1097/CORR.0000000000004174 [doi] AB - BACKGROUND: Adolescent idiopathic scoliosis (AIS) is often associated with restrictive pulmonary dysfunction, but the mechanistic pathway linking thoracic deformity to impaired lung function remains unclear. Although prior studies have used dynamic MRI to assess lung volumes or chest-wall motion, it remains unclear how MRI-derived lung volumes relate to three-dimensional thoracic deformity and pulmonary function and whether inspiratory lung volume accounts for part of these associations. QUESTIONS/PURPOSES: (1) What are the pulmonary function and dynamic lung volume characteristics in patients with AIS? (2) What are the spinal and thoracic deformity characteristics in patients with AIS? (3) What are the associations among spinal and thoracic deformity, dynamic lung volume, and pulmonary function? (4) Does total inspiratory lung volume help explain the association between thoracic deformity parameters and pulmonary function? METHODS: In this retrospective cross-sectional study, all patients were evaluated before surgery and were candidates for surgical correction at the time of study inclusion. Of 183 patients with AIS screened, 62.3% (114) met the inclusion criteria and were included (age range 10 to 18 years; 72.8% [83 of 114] female). All patients underwent standing radiographs, low-dose chest CT, dynamic chest MRI at end inspiration and end expiration, and pulmonary function testing. Patients were classified into two groups: those with restrictive dysfunction (61% [69]) and those with normal pulmonary function (39% [45]). There were no differences between the groups in age, sex, or BMI. Deformity parameters included the main thoracic curve Cobb angle, main thoracic curve rib-vertebral angle difference, space available for lung, posterior hemithoracic symmetry ratio, thoracic rotation, and sagittal diameter. Lung volumes (right, left, total) were reconstructed from MRI. Because several continuous variables were not normally distributed, we used the Mann-Whitney U test to compare the two groups for pulmonary function, lung volumes, and deformity parameters. We assessed correlations among these variables using Spearman analysis. We performed mediation analysis with 5000 bootstrap resamples to evaluate whether inspiratory lung volume helps explain the association between thoracic deformity and pulmonary function. Mediation analysis tested the role of an intermediate factor in the relationship between two variables. RESULTS: Data are presented as medians (range) unless otherwise specified. Of the 114 patients, 61% (69) had restrictive ventilatory dysfunction and 39% (45) had normal pulmonary function. Patients with restrictive ventilatory dysfunction had lower percent predicted forced vital capacity (FVC%) (median [range] 68% [36% to 80%] versus 90% [81% to 117%], difference of medians -22 percentage points; p < 0.001) and percent predicted forced expiratory volume in 1 second (FEV1%) (66% [30% to 87%] versus 87% [81% to 106%], difference of medians -21 percentage points; p < 0.001). Total median (range) inspiratory and expiratory lung volumes were also lower (2168 mL [1012 to 4733] versus 2807 mL [1012 to 4716], difference of medians -639 mL; p < 0.001 and 1300 mL [400 to 2899] versus 1604 mL [793 to 3161], difference of medians -304 mL; p = 0.006), but we could not demonstrate a difference in total inspiratory-expiratory volume change (767 mL [185 to 2622] versus 1002 mL [219 to 2889], difference of medians -235 mL; p = 0.32). They also had greater median [range] main thoracic Cobb angles (86 degrees [42 degrees to 121 degrees ] versus 54 degrees [41 degrees to 81 degrees ], difference of medians 32 degrees ; p < 0.001), greater main thoracic rib-vertebral angle differences (52 degrees [16 degrees to 78 degrees ] versus 17 degrees [2 degrees to 40 degrees ], difference of medians 35 degrees ; p < 0.001), and smaller sagittal thoracic diameters (69 mm [38 to 148] versus 88 mm [56 to 144], difference of medians -19 mm; p = 0.04). Because this study did not establish patient-level thresholds for MRI-derived lung volumes or thoracic measurements, the clinical importance of these differences remains uncertain. Greater rib-vertebral asymmetry was associated with lower FVC% and FEV1% (rs = -0.84 and -0.81, respectively; both adjusted p < 0.001), whereas larger total inspiratory lung volume was associated with higher FVC% and FEV1% (rs = 0.65 and 0.59, respectively; both adjusted p < 0.001). Thus, pulmonary function was related to both thoracic shape and inspiratory lung volume, but whether these measurements improve clinical assessment was not evaluated. Total inspiratory lung volume accounted for part of the observed relationship between thoracic deformity and pulmonary function. For FVC%, indirect effects were observed for the main thoracic Cobb angle (-0.15 [95% confidence interval (CI) -0.28 to -0.004]), thoracic rotation (-0.20 [95% CI -0.40 to -0.06]), and sagittal thoracic diameter (0.24 [95% CI 0.12 to 0.36]), with mediation proportions of 38.6%, 26.9%, and 76.6%, respectively; for FEV1%, an indirect effect was observed only for thoracic rotation (-0.16 [95% CI -0.40 to -0.04]; mediation proportion 20.4%). Because all measurements were obtained at one time point, these findings do not show that reduced inspiratory lung volume causes poorer pulmonary function. CONCLUSION: In patients with AIS, greater thoracic deformity was associated with smaller lung volumes and poorer pulmonary function. Mediation analysis suggested that total inspiratory lung volume partly accounted for the association between thoracic deformity and pulmonary function. As a radiation-free imaging modality, dynamic MRI may complement radiographic deformity assessment and routine pulmonary function testing by quantifying inspiratory and expiratory lung volumes across the respiratory cycle. Prospective longitudinal validation using posture-matched imaging and pulmonary function testing, including postoperative follow-up, is needed to determine whether these measurements improve clinical assessment and treatment planning. LEVEL OF EVIDENCE: Level III, prognostic study. CI - Copyright (c) 2026 by the Association of Bone and Joint Surgeons. FAU - Wang, Kun AU - Wang K AD - The Second Clinical Medical College, Lanzhou University, Lanzhou, PR China. AD - Key Laboratory of Orthopedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, PR China. FAU - Sun, Yong AU - Sun Y AD - The Second Clinical Medical College, Lanzhou University, Lanzhou, PR China. AD - Key Laboratory of Orthopedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, PR China. FAU - Wang, Wentao AU - Wang W AD - The Second Clinical Medical College, Lanzhou University, Lanzhou, PR China. AD - Key Laboratory of Orthopedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, PR China. FAU - Jing, Rongchao AU - Jing R AD - Spinal Department of Orthopedics, Jinan Zhangqiu District Hospital of TCM, Jinan, PR China. FAU - Kang, Xuewen AU - Kang X AD - Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, PR China. AD - The Second Clinical Medical College, Lanzhou University, Lanzhou, PR China. FAU - Cheng, Zhiquan AU - Cheng Z AD - The Second Clinical Medical College, Lanzhou University, Lanzhou, PR China. AD - Key Laboratory of Orthopedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, PR China. FAU - Mu, Xuan AU - Mu X AD - The Second Clinical Medical College, Lanzhou University, Lanzhou, PR China. AD - Key Laboratory of Orthopedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, PR China. FAU - Zhang, Guangzhi AU - Zhang G AD - Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, PR China. AD - The Second Clinical Medical College, Lanzhou University, Lanzhou, PR China. FAU - Wang, Yonggang AU - Wang Y AUID- ORCID: 0009-0007-9275-1301 AD - Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, PR China. AD - The Second Clinical Medical College, Lanzhou University, Lanzhou, PR China. LA - eng PT - Journal Article DEP - 20261026 PL - United States TA - Clin Orthop Relat Res JT - Clinical orthopaedics and related research JID - 0075674 SB - IM COIS- Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research(R) editors and board members are on file with the publication and can be viewed on request. EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:31 CRDT- 2026/10/26 11:33 PHST- 2026/04/28 00:00 [received] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/26 17:31 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 11:33 [entrez] AID - 00003086-990000000-02654 [pii] AID - 10.1097/CORR.0000000000004174 [doi] PST - aheadofprint SO - Clin Orthop Relat Res. 2026 Oct 26. doi: 10.1097/CORR.0000000000004174. PMID- 42931504 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261028 IS - 2072-6651 (Electronic) IS - 2072-6651 (Linking) VI - 18 IP - 10 DP - 2026 Sep 24 TI - Occurrence and Dietary Exposure Assessment of Patulin and Major Alternaria Toxins in Commercial Infant Fruit Purees from Italian and Spanish Markets Using Targeted Analysis and Suspect Screening. LID - 10.3390/toxins18100413 [doi] LID - 413 AB - The aim of this study was to evaluate the co-occurrence and to assess the dietary health risk of multiple mycotoxins in fruit-based purees intended for infant consumption, combining targeted quantification and dietary exposure assessment with high-resolution suspect screening. Forty samples with varying apple content were randomly collected from Italian (n = 20) and Spanish markets (n = 20). A fit-for-purpose ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for the simultaneous determination of patulin (PAT) and three Alternaria toxins, including alternariol (AOH), alternariol monomethyl ether (AME), and tentoxin (TEN), providing satisfactory sensitivity, accuracy and precision. Targeted analysis revealed frequent co-occurrence of PAT, AOH, and AME, whereas TEN was not detected. Dietary exposure assessment indicated that PAT posed negligible health risks, whereas AOH and AME exceeded their respective Thresholds of Toxicological Concern (TTCs) across all evaluated population groups, indicating Alternaria toxins as the main contributors to dietary risk. High-resolution mass spectrometry (HRMS) suspect screening expanded the mycotoxin profile through the identification of tenuazonic acid, the tentative identification of altenusin and aflatoxin G2, and the annotation of 2,3-dihydroxybenzoic acid, a potential interferent in PAT determination. Overall, the proposed workflow provides a comprehensive strategy for mycotoxin monitoring in infant fruit purees and supports enhanced surveillance of emerging Alternaria toxins. FAU - Pambianco, Enrico AU - Pambianco E AUID- ORCID: 0009-0003-8765-3337 AD - Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. AD - Department of Chemistry and Physics, University of Almeria, Carretera de Sacramento s/n, 04120 Almeria, Spain. FAU - Mihalache, Octavian Augustin AU - Mihalache OA AUID- ORCID: 0000-0003-3379-8437 AD - Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. FAU - Dall'Asta, Chiara AU - Dall'Asta C AUID- ORCID: 0000-0003-0716-8394 AD - Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. FAU - Frenich, Antonia Garrido AU - Frenich AG AUID- ORCID: 0000-0002-7904-7842 AD - Department of Chemistry and Physics, University of Almeria, Carretera de Sacramento s/n, 04120 Almeria, Spain. FAU - Carbonell-Rozas, Laura AU - Carbonell-Rozas L AUID- ORCID: 0000-0002-2193-3737 AD - Department of Chemistry and Physics, University of Almeria, Carretera de Sacramento s/n, 04120 Almeria, Spain. AD - R&D Department, Tentamus Iberia, Unit B-7, Calle Arbol del Amor, s/n, 04007 Almeria, Spain. LA - eng GR - 2022-1-IT02-KA131-HED-000061117/355723/Erasmus+ Programme of the European Union/ GR - MCIN/AEI/10.13039/501100011033/"Juan de la Cierva" postdoctoral program/ PT - Journal Article DEP - 20260924 PL - Switzerland TA - Toxins (Basel) JT - Toxins JID - 101530765 RN - 95X2BV4W8R (Patulin) RN - 0 (Mycotoxins) SB - IM MH - *Patulin/analysis MH - *Food Contamination/analysis MH - *Alternaria MH - *Mycotoxins/analysis MH - Tandem Mass Spectrometry MH - Humans MH - *Dietary Exposure/analysis MH - *Fruit/chemistry MH - Spain MH - *Infant Food/analysis MH - Italy MH - Chromatography, High Pressure Liquid MH - *Malus/chemistry PMC - PMC13709402 OTO - NOTNLM OT - Alternaria toxins OT - HRMS suspect screening OT - UHPLC-MS/MS OT - exposure assessment OT - fruit purees OT - infant food OT - mycotoxins OT - patulin OT - risk characterization COIS- Laura Carbonell-Rozas works for the company Tentamus Iberia, and the other authors declare that there is no conflict of interest. EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:32 PMCR- 2026/09/24 CRDT- 2026/10/26 11:23 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/18 00:00 [revised] PHST- 2026/09/20 00:00 [accepted] PHST- 2026/10/26 17:32 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 11:23 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - toxins18100413 [pii] AID - toxins-18-00413 [pii] AID - 10.3390/toxins18100413 [doi] PST - epublish SO - Toxins (Basel). 2026 Sep 24;18(10):413. doi: 10.3390/toxins18100413. PMID- 42931108 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261026 LR - 20261028 IS - 2036-749X (Print) IS - 2036-7503 (Electronic) IS - 2036-749X (Linking) VI - 18 IP - 5 DP - 2026 Oct 12 TI - Physical Fitness Outcomes in Youth with Autism Spectrum Disorder Following Judo Training in Inclusive Settings with Neurotypical Peers. LID - 10.3390/pediatric18050138 [doi] LID - 138 AB - BACKGROUND: Physical fitness plays an important role in healthy development; however, children and adolescents with autism spectrum disorder (ASD) typically demonstrate lower physical fitness levels than their neurotypical peers. This study examined changes in physical fitness during 10 months of judo training in inclusive groups. METHODS: Ninety children and adolescents aged 7-14 years (36 with ASD and 54 neurotypical peers) participated. Physical fitness was assessed with the EUROFIT test battery at baseline and after 5 and 10 months of training. RESULTS: Both groups significantly improved in overall physical fitness and in most individual tests. The Group x Time interaction was significant only for balance, flexibility, and the total EUROFIT (European Physical Fitness Test Battery) score; in the remaining tests, both groups changed at similar rates. CONCLUSIONS: Judo training conducted in inclusive groups may be a valuable form of physical activity for children and adolescents with ASD, as it was accompanied by improvements in physical fitness. The findings also support the feasibility of implementing judo programs in inclusive settings. FAU - Jalowska, Pola AU - Jalowska P AUID- ORCID: 0000-0002-4173-3353 AD - Department of Sport and Defence Education, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Prokopczyk, Adam AU - Prokopczyk A AUID- ORCID: 0000-0002-6694-7251 AD - Department of Sport and Defence Education, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Sokolowski, Marek AU - Sokolowski M AD - Department of Sport and Defence Education, Poznan University of Physical Education, 61-871 Poznan, Poland. LA - eng GR - Poznan University of Physical Education/ PT - Journal Article DEP - 20261012 PL - Switzerland TA - Pediatr Rep JT - Pediatric reports JID - 101551542 PMC - PMC13708347 OTO - NOTNLM OT - ASD OT - adapted physical activity OT - autism spectrum disorder OT - inclusive sport OT - judo OT - martial arts OT - physical fitness COIS- The authors declare no conflicts of interest. EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:32 PMCR- 2026/10/12 CRDT- 2026/10/26 11:13 PHST- 2026/09/01 00:00 [received] PHST- 2026/10/02 00:00 [revised] PHST- 2026/10/09 00:00 [accepted] PHST- 2026/10/26 17:32 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 11:13 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - pediatric18050138 [pii] AID - pediatrrep-18-00138 [pii] AID - 10.3390/pediatric18050138 [doi] PST - epublish SO - Pediatr Rep. 2026 Oct 12;18(5):138. doi: 10.3390/pediatric18050138. PMID- 42931102 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261026 LR - 20261028 IS - 2036-749X (Print) IS - 2036-7503 (Electronic) IS - 2036-749X (Linking) VI - 18 IP - 5 DP - 2026 Oct 2 TI - Plasma Vitamin C, 25-Hydroxyvitamin D, and the Lactate-to-Albumin Ratio at PICU Admission in Survivors and Non-Survivors of Phoenix-Defined Pediatric Sepsis and Septic Shock: An Exploratory Prospective Cohort Study. LID - 10.3390/pediatric18050132 [doi] LID - 132 AB - BACKGROUND: Vitamin C, 25-hydroxyvitamin D (25[OH]D), and the lactate-to-albumin ratio (LAR) have been proposed as prognostic markers in sepsis. However, pediatric data are limited, and these markers have not been evaluated together in a cohort classified according to the Phoenix criteria. We quantified these markers at pediatric intensive care unit (PICU) admission and assessed their unadjusted association with mortality. METHODS: This single-center prospective cohort study followed the STROBE statement. We enrolled consecutive children aged 1 month to 17 years with suspected infection and a Phoenix Sepsis Score of at least 2; septic shock required at least one cardiovascular point. Blood was sampled within 1 h of admission. We analyzed ascorbate by ultra-high-performance liquid chromatography coupled with mass spectrometry in light-protected heparin plasma. The endpoint was pre-discharge PICU mortality. We expressed differences as Hodges-Lehmann estimates with exact 95% confidence intervals (CIs), and discrimination as the area under the receiver operating characteristic curve (AUC). The five principal biomarker comparisons were subjected to Benjamini-Hochberg false discovery rate (FDR) control. We fitted no multivariable model (11 events). RESULTS: Of the 37 children enrolled, 33 (89.2%) had septic shock, and the mortality rate was 29.7%. Non-survivors had lower plasma vitamin C concentrations (51.1 vs. 73.8 umol/L; difference -17.0, 95% CI -28.4 to -5.7, p = 0.028, q = 0.141, AUC 0.73, 95% CI 0.55-0.90), and mortality declined across ascending vitamin C tertiles, although the gradient was not statistically significant (p = 0.058). No patient had hypovitaminosis C (<23 umol/L). We did not detect an association between 25(OH)D, lactate, albumin, or the LAR and mortality (all p >/= 0.18; AUC 0.50-0.64), and the LAR was collinear with lactate (rho = 0.95). The weight-for-age z-score correlated with vitamin C (rho = 0.39, p = 0.033). CONCLUSIONS: In this small cohort, non-survivors had lower plasma vitamin C concentrations within the replete range in unadjusted analysis; this difference did not persist after FDR control or in the subgroup with evaluable nutritional status, and nutritional confounding cannot be excluded. No association with mortality was detected for 25(OH)D, lactate, albumin, or the LAR. These findings are hypothesis-generating, do not establish prognostic value, and require multicenter confirmation. FAU - Martinez-Garcia, Jesus J AU - Martinez-Garcia JJ AUID- ORCID: 0000-0002-9555-262X AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Canizalez-Roman, Adrian AU - Canizalez-Roman A AUID- ORCID: 0000-0001-8605-0639 AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. AD - The Women's Hospital, Secretariat of Health, Culiacan 80020, Sinaloa, Mexico. FAU - Zatarain-Lopez, Ricardo AU - Zatarain-Lopez R AD - Centro de Investigacion y Docencia en Ciencias de la Salud (CIDOCS), Autonomous University of Sinaloa, Culiacan 80030, Sinaloa, Mexico. FAU - Cazarez-Aguilar, Marcel Antonio AU - Cazarez-Aguilar MA AD - Centro de Investigacion y Docencia en Ciencias de la Salud (CIDOCS), Autonomous University of Sinaloa, Culiacan 80030, Sinaloa, Mexico. FAU - Bolivar-Rodriguez, Martin Adrian AU - Bolivar-Rodriguez MA AUID- ORCID: 0000-0002-7666-7974 AD - Centro de Investigacion y Docencia en Ciencias de la Salud (CIDOCS), Autonomous University of Sinaloa, Culiacan 80030, Sinaloa, Mexico. FAU - Velazquez-Lopez, Luis AU - Velazquez-Lopez L AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. FAU - Osuna-Ramirez, Carlos Alberto AU - Osuna-Ramirez CA AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. FAU - Correa-Flores, Manuel A AU - Correa-Flores MA AD - IMSS Bienestar Legaria Pediatric Hospital, Mexico City 11260, Mexico. FAU - Garcia-de Leon, Maria Fernanda AU - Garcia-de Leon MF AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. FAU - Acosta-Smith, Erika AU - Acosta-Smith E AUID- ORCID: 0000-0001-8313-6699 AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Velazquez-Roman, Jorge AU - Velazquez-Roman J AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Flores-Villasenor, Hector AU - Flores-Villasenor H AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Angulo-Zamudio, Uriel A AU - Angulo-Zamudio UA AUID- ORCID: 0000-0003-2733-0766 AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Leon-Sicairos, Nidia AU - Leon-Sicairos N AUID- ORCID: 0000-0003-1470-3383 AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. LA - eng PT - Journal Article DEP - 20261002 PL - Switzerland TA - Pediatr Rep JT - Pediatric reports JID - 101551542 PMC - PMC13708177 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - Phoenix criteria OT - ascorbic acid OT - lactate-to-albumin ratio OT - mortality OT - pediatric intensive care unit OT - pediatric sepsis OT - vitamin C COIS- The authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare no conflicts of interest. EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:32 PMCR- 2026/10/02 CRDT- 2026/10/26 11:13 PHST- 2026/08/25 00:00 [received] PHST- 2026/09/28 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/26 17:32 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 11:13 [entrez] PHST- 2026/10/02 00:00 [pmc-release] AID - pediatric18050132 [pii] AID - pediatrrep-18-00132 [pii] AID - 10.3390/pediatric18050132 [doi] PST - epublish SO - Pediatr Rep. 2026 Oct 2;18(5):132. doi: 10.3390/pediatric18050132. PMID- 42931089 OWN - NLM STAT- Publisher LR - 20261026 IS - 1911-9828 (Electronic) IS - 0008-4174 (Linking) DP - 2026 Oct 26 TI - Test-retest Reliability of Creyos Test Battery in Adolescents at Risk of Concussion. PG - 84174261488757 LID - 10.1177/00084174261488757 [doi] AB - Background: Creyos is a computerized neurocognitive test battery that is widely used to assess cognition. Purpose: To evaluate the test-retest reliability of Creyos subtests for adolescents. Method: Reliability was analyzed using intraclass correlation coefficients and Bland-Altman 95% limits of agreement. Linear mixed-effects models were employed to examine change in scores over time for each subtest (a) overall; and (b) by sex. Findings: Participants included 71 adolescents ages 12-18 (median age 15, 49% female) who participated in at least one sport with a high risk of concussion. Results indicated poor-to-moderate reliability and wide limits of agreement across all subtests. Learning effects were apparent on several subtests; one subtest showed learning effects for both females and males. One subtest showed a significant difference in reliability between sexes. Conclusion: Reliability was poor-to-moderate across all subtests. Generally, reliability and learning effects did not differ by sex. Given concerns about the reliability of Creyos, occupational therapists should exercise caution when interpreting test scores to inform return to school and sport management in adolescents post-concussion. In the future, randomizing the order of subtest presentation and standardizing the test administration process may provide greater insight into the reliability of Creyos in adolescents. FAU - Shepherd, Heather A AU - Shepherd HA AUID- ORCID: 0000-0003-0665-8674 AD - School of Occupational Therapy, Faculty of Health Sciences, Western University, London, Canada. RINGGOLD: 6221 AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada. RINGGOLD: 2129 FAU - Galarneau, Jean-Michel AU - Galarneau JM AUID- ORCID: 0000-0003-3784-8753 AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada. RINGGOLD: 157744. RINGGOLD: 2129 AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - O'Brien Institute for Public Health, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada. RINGGOLD: 2129 FAU - Faris, Emily K AU - Faris EK AD - Independent Scholar. FAU - Yeates, Keith O AU - Yeates KO AUID- ORCID: 0000-0001-7680-2892 AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada. RINGGOLD: 157744. RINGGOLD: 2129 AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Department of Psychology, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada. RINGGOLD: 2129 FAU - Emery, Carolyn A AU - Emery CA AUID- ORCID: 0000-0002-9499-6691 AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada. RINGGOLD: 157744. RINGGOLD: 2129 AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - O'Brien Institute for Public Health, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. RINGGOLD: 2129 LA - eng PT - Journal Article DEP - 20261026 PL - United States TA - Can J Occup Ther JT - Canadian journal of occupational therapy. Revue canadienne d'ergotherapie JID - 0406021 SB - IM OTO - NOTNLM OT - Adolescent OT - Adolescents OT - Assessment OT - Commotion cerebrale OT - Concussion OT - Digital technology OT - Fiabilite OT - Reliability OT - Technologie numerique OT - Evaluation EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:31 CRDT- 2026/10/26 11:13 PHST- 2026/10/26 17:31 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 11:13 [entrez] AID - 10.1177/00084174261488757 [doi] PST - aheadofprint SO - Can J Occup Ther. 2026 Oct 26:84174261488757. doi: 10.1177/00084174261488757. PMID- 42930806 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261026 LR - 20261028 IS - 2075-4426 (Print) IS - 2075-4426 (Electronic) IS - 2075-4426 (Linking) VI - 16 IP - 10 DP - 2026 Oct 16 TI - Beyond Mallampati: From Universal Bedside Tests to Precision Airway Risk Stratification. LID - 10.3390/jpm16100532 [doi] LID - 532 AB - Airway management remains one of the few domains of anaesthetic practice still governed by universal, dichotomous screening thresholds applied to profoundly heterogeneous populations. Conventional bedside tests-the modified Mallampati test, thyromental distance and the upper lip bite test-retain modest and inconsistent diagnostic accuracy, leaving the majority of difficult intubations unanticipated while generating false alarms that drive resource-intensive contingency plans. This narrative review reframes preoperative airway evaluation as a problem of individualised risk stratification rather than population screening. We first summarise the performance limits of classical bedside predictors and the reasons for their ceiling effect, including low target prevalence, inter-observer variability, spectrum bias and heterogeneous outcome definitions. We then examine the data streams reshaping the field: point-of-care upper airway ultrasound, whose parameters provide operator-accessible and objective anatomical information; cross-sectional and craniofacial imaging; and machine-learning models based on clinical variables, facial images and voice analysis. For each we discuss accuracy, reproducibility, validation status and barriers to adoption. We then propose a phenotype-oriented framework in which assessment intensity is matched to pre-test probability, with dedicated pathways for obesity and obstructive sleep apnoea, obstetric, head-and-neck oncological and post-radiotherapy, critically ill and emergency, and paediatric populations. We map this framework onto the 2025 European Society of Anaesthesiology and Intensive Care and Difficult Airway Society recommendations and outline the validation, calibration and equity requirements-including algorithmic bias across skin tone, sex and ethnicity-that must be met before precision airway assessment can enter routine practice. FAU - Paterno, Daniele Salvatore AU - Paterno DS AUID- ORCID: 0009-0003-0215-5620 AD - Department of Anaesthesia and Intensive Care, "Giovanni Paolo II" Hospital, 97100 Ragusa, Italy. FAU - La Via, Luigi AU - La Via L AUID- ORCID: 0000-0002-2156-7554 AD - Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, Italy. FAU - Arena, Flavia Paola AU - Arena FP AD - Postgraduate School of Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. FAU - Barbagallo, Francesca AU - Barbagallo F AD - Postgraduate School of Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. FAU - Cala, Basilio Davide Lesina AU - Cala BDL AUID- ORCID: 0009-0002-7764-224X AD - Postgraduate School of Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. FAU - Giudice, Emilia Concetta Lo AU - Giudice ECL AD - Department of Anaesthesia and Intensive Care, "Umberto I" Hospital, 94100 Enna, Italy. AD - School of Medicine, Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. FAU - Cataldo, Rita AU - Cataldo R AUID- ORCID: 0000-0002-5821-6133 AD - Unit of Anaesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy. AD - Research Unit of Anaesthesia and Intensive Care, Department of Medicine and Surgery, Universita Campus Bio-Medico, 00128 Rome, Italy. FAU - Sorbello, Massimiliano AU - Sorbello M AUID- ORCID: 0000-0002-9331-2788 AD - Department of Anaesthesia and Intensive Care, "Giovanni Paolo II" Hospital, 97100 Ragusa, Italy. AD - School of Medicine, Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. LA - eng PT - Journal Article PT - Review DEP - 20261016 PL - Switzerland TA - J Pers Med JT - Journal of personalized medicine JID - 101602269 PMC - PMC13706562 OTO - NOTNLM OT - airway management OT - difficult intubation OT - machine learning OT - patient phenotype OT - perioperative care OT - personalised medicine OT - point-of-care ultrasound OT - precision medicine OT - risk stratification OT - videolaryngoscopy COIS- M.S. has received paid consultancy from Teleflex Medical, Verathon Medical and DEAS Italia; he is a patent co-owner (no royalties) of DEAS Italia. M.S. has signed non-disclosure agreements with Flexicare (UK) and AiEndoscopic (Switzerland), and has received paid consultancy from Flexicare (UK). M.S. is a member of the PUMA Writing Group and immediate past President of the European Airway Management Society (EAMS). L.L.V. and D.S.P. have signed a non-disclosure agreement with AiEndoscopic (Switzerland). E.C.L.G., F.P.A., F.B., B.D.L.C. and R.C. declare no conflicts of interest. EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:32 PMCR- 2026/10/16 CRDT- 2026/10/26 11:04 PHST- 2026/08/20 00:00 [received] PHST- 2026/09/15 00:00 [revised] PHST- 2026/10/14 00:00 [accepted] PHST- 2026/10/26 17:32 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 11:04 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - jpm16100532 [pii] AID - jpm-16-00532 [pii] AID - 10.3390/jpm16100532 [doi] PST - epublish SO - J Pers Med. 2026 Oct 16;16(10):532. doi: 10.3390/jpm16100532. PMID- 42929285 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261027 IS - 1478-9523 (Electronic) IS - 1478-9515 (Linking) VI - 24 DP - 2026 Oct 26 TI - Preliminary feasibility, acceptability, and "proof of concept" of a cultural adaptation of meaning-centered psychotherapy for Chinese immigrants with advanced cancer (MCP-Ch). PG - e281 LID - 10.1017/S147895152610354X [doi] AB - OBJECTIVES: To determine the preliminary feasibility, acceptability, and effects of the "Meaning-in-Life Counseling Program," a cultural adaptation of meaning-centered psychotherapy for Chinese immigrants with advanced cancer (MCP-Ch). METHODS: Mandarin-speaking stage III/IV cancer patients were enrolled in 2 pilot trials of MCP-Ch, a manualized, one-on-one intervention that used psychoeducation, experiential exercises, and structured discussion to explore themes related to meaning, identity, and purpose. Participants completed 6 weekly sessions in Mandarin Chinese with a bilingual interventionist, 45-60 minutes in length, via videoconferencing or phone. Participants were administered measures of spiritual well-being, quality of life (QOL), depression, anxiety, hopelessness, and meaning-in-life pre-intervention (T1) and 1-month post-intervention (T2) and were additionally administered an exit survey at T2. Descriptive data from participants who initiated MCP-Ch sessions (n = 31) were pooled. RESULTS: In total, 31 of 42 participants across the 2 trials started the MCP-Ch intervention, and 28 completed all 6 sessions. Results showed small to moderate postintervention improvements in spiritual well-being, QOL, anxiety, and depression. Participants provided positive feedback about MCP-Ch (89% expressed satisfaction with the intervention). A majority (50-86%) suggested additional components (i.e., cancer health education, Chinese-language peer support) to increase the intervention's relevance and acceptability. SIGNIFICANCE OF RESULTS: Overall, preliminary data suggest that this 6-session, manualized intervention is associated with improvements in psychological functioning. However, feedback from stakeholders suggests additional components could enhance the intervention's relevance. Future research should examine MCP-Ch with these additional components. FAU - Lui, Florence AU - Lui F AUID- ORCID: 0000-0001-6434-701X AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Leng, Jennifer AU - Leng J AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Lichtenthal, Wendy G AU - Lichtenthal WG AUID- ORCID: 0000-0003-3597-7826 AD - Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Costas-Muniz, Rosario AU - Costas-Muniz R AUID- ORCID: 0000-0003-0942-5657 AD - Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Chang, Fennie AU - Chang F AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Kasuga, Emily AU - Kasuga E AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Zhao, Corina AU - Zhao C AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Li, Yuelin AU - Li Y AD - Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Gany, Francesca AU - Gany F AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Breitbart, Bill AU - Breitbart B AD - Memorial Sloan-Kettering Cancer Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. LA - eng GR - 1R03CA267333-01A1,P30 CA008748,T32CA009461,U54CA137788 & U54CA132378/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20261026 PL - England TA - Palliat Support Care JT - Palliative & supportive care JID - 101232529 RN - Chinese people SB - IM MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Adaptation, Psychological MH - China/ethnology MH - *Emigrants and Immigrants/psychology/statistics & numerical data MH - Feasibility Studies MH - *Neoplasms/psychology/complications/therapy MH - Pilot Projects MH - *Psychotherapy/methods/standards MH - Quality of Life/psychology MH - Surveys and Questionnaires MH - Adolescent MH - Young Adult MH - East Asian People OTO - NOTNLM OT - Chinese Americans OT - cultural adaptation OT - existential OT - meaning-centered psychotherapy OT - psychotherapy EDAT- 2026/10/26 11:29 MHDA- 2026/10/26 11:30 CRDT- 2026/10/26 06:44 PHST- 2026/10/26 11:30 [medline] PHST- 2026/10/26 11:29 [pubmed] PHST- 2026/10/26 06:44 [entrez] AID - S147895152610354X [pii] AID - 10.1017/S147895152610354X [doi] PST - epublish SO - Palliat Support Care. 2026 Oct 26;24:e281. doi: 10.1017/S147895152610354X. PMID- 42928734 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261026 LR - 20261027 IS - 2688-2663 (Electronic) IS - 2688-2663 (Linking) VI - 7 IP - 11 DP - 2026 Nov TI - Effectiveness of a School-Centered Intervention for Myopia and Obesity Comorbidity in Children: A Cluster-Randomized Trial. PG - e71092 LID - 10.1002/mco2.71092 [doi] LID - e71092 AB - The rising comorbidity of myopia and overweight/obesity (OWOB) in children shares modifiable behavioral pathways, yet evidence for integrated prevention remains limited. We conducted a cluster-randomized, hybrid type I effectiveness-implementation trial in 36 pair-matched Beijing schools. Of 4991 enrolled students in Grades 1-4 and 7, 3426 (68.6%) completed the 12-month follow-up. The school-centered "22510SS" intervention targeted outdoor activity, screen time, diet, sleep, and health monitoring. No statistically significant between-group differences were observed in spherical equivalent or BMI change, or in the prevalence of myopia, OWOB, or their comorbidity. The intervention improved the overall behavior-improvement rate (39.7% vs. 33.7%; OR, 1.34; 95% CI, 1.00-1.80). In a prespecified analysis, students in Grades 1-4 showed slower myopia progression (OR, 0.46; 95% CI, 0.25-0.86); an exploratory analysis suggested benefits among children from less supportive family environments. Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) evaluation showed 100% fidelity for school-based activities, approximately 60% completion of family-facing health-tip dissemination, an incremental cost of yen215.43 per participant, and a Program Sustainability Assessment Tool (PSAT) score of 6.10/7. The intervention was feasible and improved targeted behaviors but did not produce significant population-level clinical effects within 12 months. Stronger family engagement and longer follow-up may be needed. Trial Registration: NCT05275959. CI - (c) 2026 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. FAU - Li, Jing AU - Li J AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Shi, Di AU - Shi D AUID- ORCID: 0000-0003-1240-7601 AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Wang, Yaqi AU - Wang Y AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Zhang, Yihang AU - Zhang Y AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Dang, Jiajia AU - Dang J AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Liu, Yunfei AU - Liu Y AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Liu, Jieyu AU - Liu J AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Chen, Ziyue AU - Chen Z AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Wang, Xinxin AU - Wang X AD - Linyi University Linyi Shandong China. FAU - Song, Jieyun AU - Song J AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Ma, Jun AU - Ma J AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Stafford, Randall S AU - Stafford RS AUID- ORCID: 0000-0003-1805-1271 AD - Stanford Prevention Research Center Palo Alto California USA. FAU - Dong, Yanhui AU - Dong Y AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. FAU - Song, Yi AU - Song Y AD - Institute of Child and Adolescent Health School of Public Health Peking University Beijing China. AD - National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China. LA - eng SI - ClinicalTrials.gov/NCT05275959 PT - Journal Article DEP - 20261025 PL - China TA - MedComm (2020) JT - MedComm JID - 101769925 PMC - PMC13695833 OTO - NOTNLM OT - RE-AIM OT - cluster-randomized trial OT - comorbidity OT - myopia OT - obesity OT - school-based intervention COIS- The authors declare no conflicts of interest. EDAT- 2026/10/26 05:30 MHDA- 2026/10/26 05:31 PMCR- 2026/10/25 CRDT- 2026/10/26 03:48 PHST- 2025/12/15 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/26 05:31 [medline] PHST- 2026/10/26 05:30 [pubmed] PHST- 2026/10/26 03:48 [entrez] PHST- 2026/10/25 00:00 [pmc-release] AID - MCO271092 [pii] AID - 10.1002/mco2.71092 [doi] PST - epublish SO - MedComm (2020). 2026 Oct 25;7(11):e71092. doi: 10.1002/mco2.71092. eCollection 2026 Nov. PMID- 42928691 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261026 IS - 1578-2735 (Electronic) IS - 1139-9287 (Print) IS - 1139-9287 (Linking) VI - 54 IP - 5 DP - 2026 Oct 15 TI - Association Among Systemic Immune-Inflammation Index, Vitamin D Status and Clinical Subtypes of ADHD: A Retrospective Investigation. PG - 1514-1526 LID - 10.62641/aep.2224 [doi] AB - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) has been linked to immune dysregulation and nutritional imbalance. The systemic immune-inflammation index (SII) is a composite inflammatory marker, while serum 25-hydroxyvitamin D (25(OH)D) reflects vitamin D status. Their joint association with paediatric ADHD remains incompletely characterised. METHODS: In this retrospective case-control study, 78 treatment-naive children with ADHD and 40 non-ADHD outpatient comparison children selected using frequency matching by age and sex were included. The most recent laboratory results available in the outpatient record were extracted. Given that some 25(OH)D values were derived from reports obtained outside our hospital, all available 25(OH)D records were manually re-checked against source documents and standardised to ng/mL prior to analysis. Group comparisons, whole-sample Spearman correlation analyses, logistic regression models including an interaction term between standardised SII and standardised 25(OH)D and exploratory receiver operating characteristic (ROC) analyses were performed. Sensitivity analysis and Firth penalised logistic regression were additionally conducted. RESULTS: Compared with the comparison group, children with ADHD had significantly higher SII, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels, together with lower serum 25(OH)D. The ADHD group was more likely to fall into lower clinically defined 25(OH)D categories, whereas the comparison group was more frequently in the >/=30 ng/mL category; this pattern remained directionally consistent after stratification by season of blood draw. In the whole study sample, SII was positively correlated with attention, impulsivity and oppositional scores, whereas serum 25(OH)D was inversely correlated with these symptom dimensions; SII was also inversely correlated with 25(OH)D. In the parsimonious model, the interaction term between standardised SII and standardised 25(OH)D was statistically significant (odds ratio (OR) = 3.06, 95% confidence interval (CI) 1.59-6.80, p = 0.002), and it remained significant in the broader sensitivity model and Firth penalised regression. In exploratory within-sample analysis, ROC curves yielded area under curves (AUCs) of 0.808 for SII, 0.781 for serum 25(OH)D and 0.836 for the parsimonious multivariable model. CONCLUSIONS: Paediatric ADHD was associated with high inflammatory burden and low serum 25(OH)D status in this retrospective outpatient sample. The statistically significant interaction between SII and 25(OH)D suggests a stable pattern of effect modification on the logistic model scale. These findings support a potentially relevant immuno-nutritional pattern in ADHD, but prospective validation is needed before causal interpretation or clinical implementation can be considered. FAU - Lu, Tingting AU - Lu T AD - Department of Child Health Care, Dongyang Maternal and Child Health Hospital, 322100 Jinhua, Zhejiang, China. FAU - Chen, Yingying AU - Chen Y AD - Department of Child Health Care, Dongyang Maternal and Child Health Hospital, 322100 Jinhua, Zhejiang, China. FAU - Hu, Feiping AU - Hu F AD - Department of Child Health Care, Dongyang Maternal and Child Health Hospital, 322100 Jinhua, Zhejiang, China. FAU - Zhu, Yingping AU - Zhu Y AD - Healthcare Department, Dongyang Maternal and Child Health Hospital, 322100 Jinhua, Zhejiang, China. LA - eng PT - Journal Article DEP - 20261015 PL - Spain TA - Actas Esp Psiquiatr JT - Actas espanolas de psiquiatria JID - 100886502 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - Retrospective Studies MH - *Attention Deficit Disorder with Hyperactivity/blood/immunology/complications MH - Male MH - Female MH - Case-Control Studies MH - *Vitamin D/blood/analogs & derivatives MH - *Inflammation/blood/complications MH - Child PMC - PMC13714461 COIS- The authors declare no conflict of interest. EDAT- 2026/10/26 05:30 MHDA- 2026/10/26 05:31 PMCR- 2026/10/15 CRDT- 2026/10/26 03:13 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/10/26 05:31 [medline] PHST- 2026/10/26 05:30 [pubmed] PHST- 2026/10/26 03:13 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - 10.62641/aep.2224 [pii] AID - 10.62641/aep.2224 [doi] PST - epublish SO - Actas Esp Psiquiatr. 2026 Oct 15;54(5):1514-1526. doi: 10.62641/aep.2224. PMID- 42928329 OWN - NLM STAT- Publisher LR - 20261026 IS - 1573-6695 (Electronic) IS - 1389-4986 (Linking) DP - 2026 Oct 26 TI - Concept Mapping Analysis of Sustainability Factors and Strategies for Childhood Obesity Prevention Programs. LID - 10.1007/s11121-026-02001-2 [doi] AB - This study aimed to identify and prioritize sustainability factors and strategies and to explore their relationships based on expert-informed concept mapping analysis. Three rounds of consultation were conducted sequentially among a total sample of 44 experienced experts in childhood obesity intervention. Experts first rated the importance and feasibility of factors and strategies related to program sustainability and then completed a card sorting task to group factors and strategies according to whether the same strategies could address them. Inter-rater agreement was assessed using the Average Deviation index. A go-zone plot was generated to visualize strategy priorities by importance and feasibility. Multidimensional scaling and hierarchical cluster analysis were used to identify clusters of sustainability factors and strategies. The results showed that "matching stakeholders' perceived needs" was rated as the most important factor, and 12 strategies were rated as both highly important and feasible in the go-zone plot. Six clusters of sustainability factors and strategies emerged: (1) alignment and collaboration, (2) workforce engagement, (3) capacity building, (4) resource security, (5) sustainability-focused enhancement, and (6) streamlining and optimization. This assessment and categorization of factors and strategies can help practitioners prioritize practices based on their specific needs and contextual conditions to sustain childhood obesity prevention programs. CI - (c) 2026. Society for Prevention Research. FAU - Pan, Shasha AU - Pan S AD - School of Public Health, Shandong Medical and Pharmaceutical University, No. 318 Gangcheng East Road, Laishan District, Yantai, Shandong, China. AD - Department of Medical Insurance and Price Management, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China. AD - School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, 215123, China. FAU - Zhang, Youjie AU - Zhang Y AUID- ORCID: 0000-0003-4319-9809 AD - School of Public Health, Shandong Medical and Pharmaceutical University, No. 318 Gangcheng East Road, Laishan District, Yantai, Shandong, China. ujzhang@sdmpu.edu.cn. LA - eng GR - 82204068/National Natural Science Foundation of China/ PT - Journal Article DEP - 20261026 PL - United States TA - Prev Sci JT - Prevention science : the official journal of the Society for Prevention Research JID - 100894724 SB - IM OTO - NOTNLM OT - Childhood obesity prevention OT - Concept mapping OT - Factors OT - Program sustainability OT - Strategies COIS- Declarations. Ethics Approval: Approval was obtained from the ethics committee of Suzhou Medical College of Soochow University. This study was conducted in accordance with the Declaration of Helsinki. Consent to Participate: All participants consented to the study procedure. Conflict of Interest: The authors declare no competing interests. Clinical Trial Registration: Not applicable. EDAT- 2026/10/26 05:30 MHDA- 2026/10/26 05:30 CRDT- 2026/10/26 00:27 PHST- 2025/12/12 00:00 [received] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/26 05:30 [medline] PHST- 2026/10/26 05:30 [pubmed] PHST- 2026/10/26 00:27 [entrez] AID - 10.1007/s11121-026-02001-2 [pii] AID - 10.1007/s11121-026-02001-2 [doi] PST - aheadofprint SO - Prev Sci. 2026 Oct 26. doi: 10.1007/s11121-026-02001-2. PMID- 42928301 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261028 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Oct 22 TI - Co-producing an assessment instrument for physical activity policies in the early childhood education and care setting. LID - 10.1186/s12966-026-02001-z [doi] LID - 102 AB - BACKGROUND: Despite the importance of physical activity (PA) for the physical, cognitive, and socio-emotional development of children, the effects of public policies on PA outcomes in early childhood education and care have only recently been investigated. As the available evidence is relatively recent, it has not yet been integrated into existing policy assessment tools. To address this gap, this study aimed to develop an instrument to assess the PA-related content of policies in early childhood education and care. METHODS: The instrument was developed through a multi-phase co-production process involving researchers and representatives from state-level health reporting authorities in Germany. Development was guided by a conceptual framework for policy content analysis and comprised three phases: (1) prototype development based on a systematic analysis of all 16 German educational framework plans, a systematic literature review on the effectiveness of public policies promoting PA in early childhood education and care, and a structured search for national and international policy recommendations; (2) expert consultation using a two-round Delphi survey (n = 24 in round 1; n = 26 in round 2), with indicators rated on a 10-point Likert scale and summarized using median scores; and (3) pilot testing in five German federal states to assess feasibility, clarity, and applicability of the instrument. RESULTS: The initial prototype of the assessment instrument comprised 24 indicators. Several revisions throughout the development process resulted in a final version containing 28 indicators across eight thematic domains (e.g., pedagogical concept, education-related objectives, outdoor PA opportunities, indoor PA opportunities). Pilot testing confirmed the instrument's applicability and feasibility within state-level health reporting, and minor refinements were made to improve the clarity and completeness of individual indicators. Time needed to complete the instrument ranged from approximately one to six hours. CONCLUSIONS: This study developed the first instrument specifically designed to assess the PA-related content of early childhood education and care policies. This may support intersectoral collaboration between the health and youth sector, and could inform future decision-making processes. Moreover, future studies may test its applicability in other countries. CI - (c) 2026. The Author(s). FAU - Brandl, Johannes AU - Brandl J AUID- ORCID: 0009-0001-1700-1339 AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Gebbertstrasse 123B, Erlangen, 91058, Germany. FAU - Oberwohrmann, Sylke AU - Oberwohrmann S AD - Senate Department for Higher Education and Research, Health, and Long-Term Care, Berlin, Germany. FAU - Finger, Jonas AU - Finger J AUID- ORCID: 0000-0003-3697-6649 AD - Senate Department for Higher Education and Research, Health, and Long-Term Care, Berlin, Germany. FAU - Till, Maike AU - Till M AUID- ORCID: 0000-0002-9915-7512 AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Gebbertstrasse 123B, Erlangen, 91058, Germany. FAU - Do, Stefanie AU - Do S AUID- ORCID: 0000-0002-7673-1809 AD - Leibniz-Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Gelius, Peter AU - Gelius P AUID- ORCID: 0000-0002-4120-4996 AD - Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland. FAU - Hebestreit, Antje AU - Hebestreit A AUID- ORCID: 0000-0001-7354-5958 AD - Leibniz-Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Messing, Sven AU - Messing S AUID- ORCID: 0000-0002-9645-4079 AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Gebbertstrasse 123B, Erlangen, 91058, Germany. sven.messing@fau.de. AD - Physical Activity for Health Research Centre, Health Research Institute, Department of Physical Education and Sport Science, University of Limerick, Limerick, Ireland. sven.messing@fau.de. LA - eng PT - Journal Article DEP - 20261022 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Germany MH - Child, Preschool MH - *Health Policy MH - *Health Promotion MH - Delphi Technique MH - *Exercise MH - *Child Day Care Centers PMC - PMC13700408 OTO - NOTNLM OT - Childcare OT - Co-production OT - Kindergarten OT - Physical activity OT - Policy assessment OT - Policy evaluation OT - Preschool OT - Tool development COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/26 05:30 MHDA- 2026/10/26 05:31 PMCR- 2026/10/22 CRDT- 2026/10/26 00:25 PHST- 2026/04/09 00:00 [received] PHST- 2026/10/17 00:00 [accepted] PHST- 2026/10/26 05:31 [medline] PHST- 2026/10/26 05:30 [pubmed] PHST- 2026/10/26 00:25 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - 10.1186/s12966-026-02001-z [pii] AID - 2001 [pii] AID - 10.1186/s12966-026-02001-z [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Oct 22;23(1):102. doi: 10.1186/s12966-026-02001-z. PMID- 42927982 OWN - NLM STAT- MEDLINE DCOM- 20261025 LR - 20261025 IS - 1475-2727 (Electronic) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Oct 26 TI - Prevalence of food insecurity in households with children under 5 years of age in Ecuador: analysis of the national child malnutrition surveys. PG - e203 LID - 10.1017/S1368980026103541 [doi] AB - OBJECTIVE: To estimate the national prevalence and distribution of food insecurity (FI) among households with children younger than 5 years in Ecuador and to evaluate the psychometric properties of the Food Insecurity Experience Scale (FIES) using two consecutive nationally representative surveys. DESIGN: This cross-sectional study employed descriptive statistics and Tobit regression models using STATA v17. SETTING: We used secondary data from the National Survey on Child Malnutrition in Ecuador, including food security (FS) information for 2022-2023 and 2023-2024, to construct the prevalence time series. PARTICIPANTS: We analysed data from 19 187 households (22 260 children) surveyed in the first round and 20 186 households (23 187 children) surveyed in the second round. RESULTS: FIES showed adequate reliability in both rounds (Rasch reliability 0.80 and 0.79). Seven of eight FIES items showed significant reductions between rounds. The prevalence of moderate-or-severe FI remained high, decreasing from 40.79 % in 2022-2023 to 39.18 % in 2023-2024 (p = 0.239). Severe FI declined significantly from 4.83 % to 3.52 % (p = 0.002). In both rounds, FI was more prevalent in rural areas, the Amazon region, priority territories, Indigenous and Afro-descendant populations and households experiencing poverty or unmet basic needs. In 2023-2024, FI was associated with priority area residence, Indigenous ethnicity, poverty due to unmet basic needs, older child age groups and stunting. CONCLUSIONS: Despite reductions in severe FI, nearly four in ten households with young children in Ecuador continue to experience moderate-or-severe FI, with persistent territorial, ethnic and socio-economic inequalities. Integrated policies linking FS, child nutrition and poverty reduction are needed. FAU - Morejon-Teran, Yadira Alejandra AU - Morejon-Teran YA AUID- ORCID: 0000-0003-2830-3081 AD - Programa de Pos-Graduacao em Saude Coletiva, Instituto de Saude Coletiva, Universidade Federal da Bahia, Salvador, Brasil. ROR: https://ror.org/03k3p7647 AD - Centro de Investigacion en Salud Publica y Epidemiologia Clinica (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador. ROR: https://ror.org/00dmdt028 FAU - Duran-Aguero, Samuel AU - Duran-Aguero S AD - Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Chile. FAU - Rios-Castillo, Israel AU - Rios-Castillo I AD - Organizacion de las Naciones Unidas para la Alimentacion y la Agricultura, Oficina Subregional de la FAO en Mesoamerica, Panama. AD - Escuela de Nutricion y Dietetica, Facultad de Medicina, Universidad de Panama, Panama, Panama. FAU - Alvim Matos, Sheila Maria AU - Alvim Matos SM AD - Instituto de Saude Coletiva, Universidade Federal da Bahia, Brazil. FAU - Rosero Mora, Gabriela AU - Rosero Mora G AD - FAO Ecuador, Food and Agriculture Organization of the United Nations (FAO), Ecuador. LA - eng PT - Journal Article DEP - 20261026 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Ecuador/epidemiology MH - *Food Insecurity MH - Child, Preschool MH - Cross-Sectional Studies MH - *Family Characteristics MH - Prevalence MH - Female MH - Infant MH - Male MH - *Child Nutrition Disorders/epidemiology MH - *Food Supply/statistics & numerical data MH - Nutrition Surveys MH - Socioeconomic Factors MH - Poverty MH - Psychometrics MH - Reproducibility of Results OTO - NOTNLM OT - children OT - food insecurity OT - food insecurity experience scale OT - malnutrition EDAT- 2026/10/25 23:29 MHDA- 2026/10/25 23:30 CRDT- 2026/10/25 21:53 PHST- 2026/10/25 23:30 [medline] PHST- 2026/10/25 23:29 [pubmed] PHST- 2026/10/25 21:53 [entrez] AID - S1368980026103541 [pii] AID - 10.1017/S1368980026103541 [doi] PST - epublish SO - Public Health Nutr. 2026 Oct 26;29(1):e203. doi: 10.1017/S1368980026103541. PMID- 42927707 OWN - NLM STAT- Publisher LR - 20261025 IS - 1878-4119 (Electronic) IS - 1010-5182 (Linking) VI - 54 IP - 12 DP - 2026 Oct 25 TI - The use of patient-specific implants: a promising strategy to reduce rigid external distractor-associated complications in syndromic craniosynostosis. PG - 109924 LID - S1010-5182(26)05481-8 [pii] LID - 10.1016/j.jcms.2026.109924 [doi] AB - BACKGROUND: Midface distraction osteogenesis (DO) with rigid external distraction (RED) is an established technique for treating severe midfacial hypoplasia in patients with syndromic craniosynostosis. However, halo-type distractors are associated with substantial device-related complications, particularly at the cranial pin fixation and midfacial anchorage sites. Patient-specific implants (PSIs) for the retention of the halo frame and the maxillary anchorage may reduce fixation-related complications while maintaining reliable force transmission and distraction vectors. METHODS: This monocentric retrospective study included a cohort of consecutively treated patients with Apert, Crouzon, or Pfeiffer syndrome who underwent Le Fort III or Wassmund III midface advancement using DO with PSI bases for the RED fixation combined with either conventional or patient-specific maxillary anchorage between January 2022 and July 2024. Demographics, perioperative parameters, achievement of the planned distraction goal, and complications classified by Clavien-Dindo were analyzed, with particular focus on distractor- and fixation-related events. RESULTS: Eight children (six boys, two girls; five Crouzon, two Pfeiffer, one Apert) were included. Mean age at surgery was 14.1 years (+/-0.4 years), and mean time to distractor removal was 3.3 months (+/-0.29 months). No intraoperative complications occurred. One patient developed a transient cerebrospinal fluid leak that resolved spontaneously (Clavien-Dindo grade I). Cranial RED fixation using PSIs was not associated with infections, loosening, migration, or transcranial penetration. One device-related complication occurred during retention (crossbar ball-joint screw loosening), managed by retightening (grade II). Three patients underwent conventional midfacial fixation using Leipzig retention plates, with one case of intraoral wound dehiscence requiring secondary suturing and antibiotics (grade II) and subjectively reduced oral hygiene/food intake. Five patients received PSI-based midfacial fixation with two transcutaneous wires; no fixation-related complications, dental injuries, or wound problems were observed. All patients achieved the planned advancement with correction of exorbitism and Angle Class III malocclusion. At mean follow-up of 25.7 months (+/-8.8 months), all patients had Whitaker Class I outcomes, with predominantly excellent aesthetic results. CONCLUSIONS: PSI-based fixation of rigid external distractors (RED) to the cranium and midface appeared to be a feasible and safe approach in this preliminary cohort. While no fixation-related complications were observed, the retrospective design, small sample size, and absence of a comparative control group preclude conclusions regarding a reduction in complication rates. Larger comparative studies are required. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Fuchs, Jennifer AU - Fuchs J AD - Department of Oral and Maxillofacial Surgery, Heidelberg University, Germany. FAU - Appel, Maximilian AU - Appel M AD - Department of Oral and Maxillofacial Surgery, Heidelberg University, Germany. FAU - Zittel, Sven AU - Zittel S AD - Department of Oral and Maxillofacial Surgery, Heidelberg University, Germany. FAU - Busch, Cornelius AU - Busch C AD - Department of Anesthesia, Heidelberg University, Germany. FAU - El Damaty, Ahmed AU - El Damaty A AD - Department of Neurosurgery, Heidelberg University, Germany. FAU - Kuhle, Reinald AU - Kuhle R AD - Department of Oral and Maxillofacial Surgery, Heidelberg University, Germany. FAU - Scheurer, Mats AU - Scheurer M AD - Department of Oral and Maxillofacial Surgery, Heidelberg University, Germany. FAU - Hoffmann, Jurgen AU - Hoffmann J AD - Department of Oral and Maxillofacial Surgery, Heidelberg University, Germany. FAU - Engel, Michael AU - Engel M AD - Department of Oral and Maxillofacial Surgery, Heidelberg University, Germany. Electronic address: Michael.engel@med.uni-heidelberg.de. LA - eng PT - Journal Article DEP - 20261025 PL - Scotland TA - J Craniomaxillofac Surg JT - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JID - 8704309 SB - IM OTO - NOTNLM OT - Craniosynostosis OT - Distraction osteogenesis OT - Le Fort III OT - Midface advancement OT - Patient-specific implants OT - Rigid external distractor COIS- Declaration of competing interests The authors declare that they have no conflicts of interest related to this study. Adalbert Frech (KLS Martin) provided technical support and illustrative materials; however, he had no influence on the study design, data collection, analysis, interpretation of data, or manuscript preparation. EDAT- 2026/10/25 23:29 MHDA- 2026/10/25 23:29 CRDT- 2026/10/25 19:02 PHST- 2026/03/22 00:00 [received] PHST- 2026/09/12 00:00 [revised] PHST- 2026/10/03 00:00 [accepted] PHST- 2026/10/25 23:29 [medline] PHST- 2026/10/25 23:29 [pubmed] PHST- 2026/10/25 19:02 [entrez] AID - S1010-5182(26)05481-8 [pii] AID - 10.1016/j.jcms.2026.109924 [doi] PST - aheadofprint SO - J Craniomaxillofac Surg. 2026 Oct 25;54(12):109924. doi: 10.1016/j.jcms.2026.109924. PMID- 42927569 OWN - NLM STAT- MEDLINE DCOM- 20261025 LR - 20261027 IS - 1436-6215 (Electronic) IS - 1436-6207 (Linking) VI - 65 IP - 8 DP - 2026 Oct 25 TI - Maternal fruit and vegetable consumption in relation to newborn anthropometric outcomes. LID - 285 [pii] LID - 10.1007/s00394-026-04136-y [doi] AB - PURPOSE: To investigate the associations between maternal consumption of fresh fruits, vegetables, and fruit juices during pregnancy and neonatal anthropometric outcomes, including birth weight, birth length and head circumference. METHODS: A prospective cohort study was conducted, including 614 mother-child pairs. Maternal diet was assessed as the average intake across the three trimesters using a validated food frequency questionnaire. Neonatal outcomes were assessed using INTERGROWTH-21st standards as continuous (z-scores) and categorical (below the 10th percentile [< P10]) measures of birth weight, birth length, and head circumference. Associations were estimated using multivariable linear and logistic regression models adjusted for relevant covariates. RESULTS: Each 100 g/day increase in combined consumption of fresh fruits and vegetables during pregnancy was associated with higher birth weight z-score (beta = 0.14 [0.01, 0.27]) and lower odds of birth weight < P10 (OR = 0.62 [0.41, 0.96]) and birth length < P10 (OR = 0.64 [0.42, 0.98]). Separately, each 100 g/day increase in vegetable consumption was associated with lower odds of birth weight < P10, whereas higher fresh fruit consumption was associated with lower odds of birth length < P10. No significant associations were observed for fruit juice consumption, and none of the dietary exposures were associated with head circumference outcomes. CONCLUSION: This study provides new evidence on maternal fresh fruit and vegetable consumption in relation to neonatal anthropometric outcomes by evaluating their overall combined intake alongside their separate consumption. These findings may help strengthen the evidence base for maternal nutritional guidance. CI - (c) 2026. Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Riggioni-Saborio, Lucia AU - Riggioni-Saborio L AUID- ORCID: 0009-0004-9880-7159 AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. FAU - Jardi, Cristina AU - Jardi C AUID- ORCID: 0000-0002-7946-1488 AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB Catsud), Tarragona, 43005, Spain. FAU - Cruz-Rodriguez, Josue AU - Cruz-Rodriguez J AUID- ORCID: 0000-0001-7145-5836 AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB Catsud), Tarragona, 43005, Spain. FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AUID- ORCID: 0000-0002-4429-6507 AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB Catsud), Tarragona, 43005, Spain. FAU - Arija, Victoria AU - Arija V AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. victoria.arija@urv.cat. AD - Institut de Recerca Biomedica Catalunya Sud (IRB Catsud), Tarragona, 43005, Spain. victoria.arija@urv.cat. AD - Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut Catala de La Salut (ICS), Institut D'Investigacio en Atencio Primaria IDIAP Jordi Gol, Reus, Spain. victoria.arija@urv.cat. AD - Institut D'Investigacio en Atencio Primaria IDIAP Jordi Gol, Institut Catala de La Salut (ICS), Barcelona, Spain. victoria.arija@urv.cat. AD - University Research Institute on Sustainability, Climate Change and Energy Transition (IU- RESCAT), Universitat Rovira i Virgili, Tarragona, 43003, Spain. victoria.arija@urv.cat. LA - eng PT - Journal Article DEP - 20261025 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - *Fruit MH - *Vegetables MH - Pregnancy MH - Prospective Studies MH - Infant, Newborn MH - *Birth Weight MH - *Maternal Nutritional Physiological Phenomena MH - *Diet/methods/statistics & numerical data MH - Adult MH - Anthropometry MH - Fruit and Vegetable Juices MH - Male OTO - NOTNLM OT - Fetal growth OT - Fruit consumption OT - Fruit juice OT - Maternal nutrition OT - Pregnancy OT - Vegetable consumption COIS- Declarations. Conflict of interest: The authors declare no conflict of interest. Consent to participate: All participants signed an informed consent form. Ethical approval: This study was approved by the Clinical Research Ethics Committee of the Jordi Gol Institute for Primary Care Research (IDIAP) and the Pere Virgili Institute for Health Research (IISPV). This study complies with the tenets of the Declaration of Helsinki. EDAT- 2026/10/25 17:31 MHDA- 2026/10/25 17:32 CRDT- 2026/10/25 12:08 PHST- 2026/07/08 00:00 [received] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/25 17:32 [medline] PHST- 2026/10/25 17:31 [pubmed] PHST- 2026/10/25 12:08 [entrez] AID - 10.1007/s00394-026-04136-y [pii] AID - 10.1007/s00394-026-04136-y [doi] PST - epublish SO - Eur J Nutr. 2026 Oct 25;65(8):285. doi: 10.1007/s00394-026-04136-y. PMID- 42927166 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261025 LR - 20261026 IS - 2214-7500 (Electronic) IS - 2214-7500 (Linking) VI - 17 DP - 2026 Dec TI - Multi-tissue accumulation of potentially toxic elements and age-stratified non-carcinogenic dietary risk in fish from the Anzali Wetland, Caspian Basin. PG - 102355 LID - 10.1016/j.toxrep.2026.102355 [doi] LID - 102355 AB - Potentially toxic elements (PTEs) in wetland fish are relevant to both environmental monitoring and dietary-exposure assessment, yet studies integrating multi-tissue accumulation with age-stratified health-risk estimates remain limited. This study quantified Al, Ba, Cu, Fe, Ni, and Zn in muscle, gill, visceral, and egg tissues of 48 fish representing northern pike (Esox lucius), common carp (Cyprinus carpio), vimba bream (Vimba vimba), and tench (Tinca tinca) from the Anzali Wetland, Iran. Element concentrations were determined using ICP-MS. Species- and tissue-related differences were evaluated using split-plot repeated-measures analysis, with structure-preserving permutation tests applied to the observed concentration data as a robustness assessment. Inter-element associations were evaluated at the independent biological-replicate level. Significant speciesxtissue interactions were detected for Al, Ba, Cu, Fe, and Zn, indicating that tissue-specific accumulation patterns differed among fish species. Ni showed a significant species effect but no significant tissue effect or species x tissue interaction. Northern pike exhibited comparatively high concentrations of Al, Fe, Ni, and Zn, whereas the most pronounced Ba accumulation occurred in vimba bream gills. After false-discovery-rate correction, significant associations were identified between Al and Fe, Cu and Ni, and Ni and Zn. Dietary exposure and non-carcinogenic risk were estimated for children, adolescents, and adults using wet-weight concentrations measured exclusively in edible muscle tissue. All estimated daily intakes remained below the selected oral toxicity benchmarks, and all individual target hazard quotients and cumulative hazard indices remained below 1. Children consistently showed the highest non-carcinogenic risk estimates. Quantitative carcinogenic risk was not assessed because the investigated elements were evaluated using non-carcinogenic oral toxicity benchmarks and validated oral cancer slope factors applicable to the measured dietary forms, particularly total Ni, were not available within the adopted assessment framework. Overall, the findings demonstrate that multi-tissue elemental accumulation and dietary exposure should be interpreted separately and indicate that appreciable non-carcinogenic effects are unlikely under the assessed muscle-consumption scenarios. CI - (c) 2026 The Authors. FAU - Salehi, Fatemeh AU - Salehi F AD - Department of Environmental Science and Engineering, Arak University, Arak, 384817758, Iran. FAU - Sharafi, Saeed AU - Sharafi S AD - Department of Environmental Science and Engineering, Arak University, Arak, 384817758, Iran. FAU - Kazemi, Ali AU - Kazemi A AD - Department of Environmental Science and Engineering, Arak University, Arak, 384817758, Iran. FAU - Esmaeilbeigi, Milad AU - Esmaeilbeigi M AD - Centre for Applied Water Science, Institute for Applied Ecology, University of Canberra, Canberra, ACT, Australia. FAU - Rahmati, Moein AU - Rahmati M AD - Department of Environmental Science and Engineering, Arak University, Arak, 384817758, Iran. LA - eng PT - Journal Article DEP - 20261013 PL - Ireland TA - Toxicol Rep JT - Toxicology reports JID - 101630272 PMC - PMC13694760 OTO - NOTNLM OT - Anzali wetland OT - Dietary exposure OT - Freshwater fish OT - Hazard index OT - Multi-tissue accumulation OT - Potentially toxic elements COIS- The authors declare no competing interests.The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/25 11:32 MHDA- 2026/10/25 11:33 PMCR- 2026/10/13 CRDT- 2026/10/25 05:05 PHST- 2026/08/13 00:00 [received] PHST- 2026/10/03 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/25 11:33 [medline] PHST- 2026/10/25 11:32 [pubmed] PHST- 2026/10/25 05:05 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - S2214-7500(26)00157-5 [pii] AID - 102355 [pii] AID - 10.1016/j.toxrep.2026.102355 [doi] PST - epublish SO - Toxicol Rep. 2026 Oct 13;17:102355. doi: 10.1016/j.toxrep.2026.102355. eCollection 2026 Dec. PMID- 42926939 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261025 LR - 20261026 IS - 3050-7081 (Electronic) IS - 3050-7081 (Linking) VI - 2 IP - 4 DP - 2026 Dec TI - 'Let's work alongside it': healthcare professionals' perspectives of generative AI in supporting care at home in paediatric rheumatology. PG - 100258 LID - 10.1016/j.ero.2026.100258 [doi] LID - 100258 AB - OBJECTIVES: Generative artificial intelligence (GenAI) is increasingly explored in healthcare, yet its potential to support care at home remains largely unexamined. In paediatric rheumatology, where families frequently undertake complex tasks to manage treatment plans between appointments, safe and effective guidance is essential. The aim of the current study was to understand healthcare professionals' (HCPs') views on adopting GenAI tools to help families manage their child's care. METHODS: Utilising a vignette-based methodology, paediatric rheumatology HCPs were invited to focus groups and presented with 3 hypothetical scenarios: (1) injection administration, (2) flare assessment, and (3) physiotherapy exercises. Following the principles outlined by Braun and Clarke, data were analysed using thematic analysis. RESULTS: A total of 37 HCPs from the wider multidisciplinary team from 14 different hospitals participated in this study. Six main themes were identified: (1) opportunities of GenAI to benefit patient care; (2) disadvantages and challenges; (3) risks, safety netting, and evaluation; (4) different approaches of utilising GenAI; (5) role of HCPs in the world of GenAI; and (6) ensuring inclusivity and accessibility. CONCLUSIONS: HCPs recognised opportunities for how GenAI could support caregivers in managing their child's healthcare or young people's self-management, particularly through guidance support rather than clinical interpretation. However, concerns were raised regarding the accuracy, reliability, privacy, and data governance of currently existing GenAI tools. The perspectives of HCPs are critical to ensuring that the application of GenAI in healthcare aligns with clinical expectations, ethical standards, regulatory processes, and the needs of patients and families. CI - Crown Copyright (c) 2026 Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR). FAU - Kupiec, Klaudia H AU - Kupiec KH AD - Department of Paediatric Rheumatology, Great Ormond Street Hospital National Health Service (NHS) Foundation Trust, London, UK. AD - University College London (UCL) Great Ormond Street Institute of Child Health, Infection, Immunity, and Inflammation Research and Teaching Department, University College London, London, UK. AD - National Institute for Health and Care Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Sweet, Sabina AU - Sweet S AD - UCL Interaction Centre, Department of Computer Science and Division of Psychology and Language Sciences, University College London, London, UK. FAU - Compeyrot-Lacassagne, Sandrine AU - Compeyrot-Lacassagne S AD - Department of Paediatric Rheumatology, Great Ormond Street Hospital National Health Service (NHS) Foundation Trust, London, UK. AD - University College London (UCL) Great Ormond Street Institute of Child Health, Infection, Immunity, and Inflammation Research and Teaching Department, University College London, London, UK. AD - National Institute for Health and Care Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Livermore, Polly AU - Livermore P AD - Department of Paediatric Rheumatology, Great Ormond Street Hospital National Health Service (NHS) Foundation Trust, London, UK. AD - University College London (UCL) Great Ormond Street Institute of Child Health, Infection, Immunity, and Inflammation Research and Teaching Department, University College London, London, UK. AD - National Institute for Health and Care Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK. LA - eng PT - Journal Article DEP - 20261019 PL - Netherlands TA - EULAR Rheumatol Open JT - EULAR rheumatology open JID - 9919228057406676 PMC - PMC13695108 COIS- All authors meet the journal's criteria for authorship, and none of the authors has any conflict of interest to declare. PL is currently receiving a personal fellowship award from the National Institute for Health and Care Research (NIHR) fellowship for nonmedical healthcare professionals (ACAF reference number 302864), and as PPIE co-lead for the NIHR GOSH BRC, she receives some salary support from the NIHR Biomedical Research Centre at GOSH. PL is also a Senior Centre Affiliate at The Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH and GOSH, which is supported by Versus Arthritis (21593). All research at Great Ormond Street Hospital NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. EDAT- 2026/10/25 05:37 MHDA- 2026/10/25 05:38 PMCR- 2026/10/19 CRDT- 2026/10/25 04:55 PHST- 2026/10/25 05:38 [medline] PHST- 2026/10/25 05:37 [pubmed] PHST- 2026/10/25 04:55 [entrez] PHST- 2026/10/19 00:00 [pmc-release] AID - S3050-7081(26)00157-6 [pii] AID - 100258 [pii] AID - 10.1016/j.ero.2026.100258 [doi] PST - epublish SO - EULAR Rheumatol Open. 2026 Oct 19;2(4):100258. doi: 10.1016/j.ero.2026.100258. eCollection 2026 Dec. PMID- 42926197 OWN - NLM STAT- Publisher LR - 20261025 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) DP - 2026 Oct 24 TI - Maternal mid-pregnancy metabolic profiles and growth trajectories across the first 36 months of life in a UK multi-ethnic birth cohort. LID - 10.1038/s41366-026-02233-w [doi] AB - OBJECTIVES: To investigate the influence of maternal mid-pregnancy metabolomic profiles on offspring anthropometric growth trajectories (weight, length/height, and BMI) across the first 36 months of life in a multi-ethnic birth cohort. METHODS: This longitudinal study analyzed 1423 mother-child pairs from the Born in Bradford cohort. Using NMR, 147 metabolites were quantified in maternal fasting blood samples collected at 26-28 weeks of gestation. Children's growth trajectories for weight, length/height, and BMI across 0-36 months of life were modeled using latent class growth mixture models. Partial least squares discriminant analysis identified key maternal metabolites distinguishing growth trajectories, followed by linear mixed-effects regression examining associations with WHO growth z-scores adjusted for a minimal set of covariates (ethnicity and gestational diabetes mellitus, GDM). RESULTS: Three distinct growth trajectories were identified for each anthropometric measure: normative, intermediate, and non-uniform (accelerated for weight and BMI or faltered for length/height). For each growth trajectory, between 30 and 41 metabolites were required to differentiate between trajectories within each anthropometric measure. Fourteen lipoprotein subclasses were required across weight, length/height, and BMI, with an additional 16 to 31 metabolites required in one or two trajectories. Numerous associations between metabolite levels and change in z-score anrthropometric measures were observed and validated within each growth trajectory (-0.47 to 1.5 for weight; -0.87 to 2.2 for height/length; and -0.85 to 1.8 for BMI; P < 0.05) per unit change in metabolite. South Asian ethnicity and GDM were associated with lower z-scores (-0.214 to -0.212 and -0.044 to -0.041 for weight; -0.061 to -0.045 and -0.104 to -0.101 for length/height; and -0.157 to -0.182 and -0.083 to -0.071 for BMI, respectively). CONCLUSIONS: Metabolomic profiles in mid-pregnancy, especially lipoproteins, characterize observed offspring growth in different directions and/or strengths in various growth trajectories from birth to 36 months of age. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Zielinska-Pukos, Monika A AU - Zielinska-Pukos MA AUID- ORCID: 0000-0001-8894-6746 AD - Food, Nutrition, and Health, University of British Columbia, Vancouver, BC, Canada. monika_zielinska_pukos@sggw.edu.pl. AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), Warsaw, Poland. monika_zielinska_pukos@sggw.edu.pl. FAU - Zulyniak, Michael A AU - Zulyniak MA AUID- ORCID: 0000-0003-4944-5521 AD - Food, Nutrition, and Health, University of British Columbia, Vancouver, BC, Canada. michael.zulyniak@ubc.ca. AD - BC Children's and Women's Hospital Health Research Institutes, Vancouver, BC, Canada. michael.zulyniak@ubc.ca. AD - Leeds Institute of Medical Research, University of Leeds, Leeds, UK. michael.zulyniak@ubc.ca. LA - eng PT - Journal Article DEP - 20261024 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/10/25 05:37 MHDA- 2026/10/25 05:37 CRDT- 2026/10/25 00:15 PHST- 2025/12/10 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/09/04 00:00 [revised] PHST- 2026/10/25 05:37 [medline] PHST- 2026/10/25 05:37 [pubmed] PHST- 2026/10/25 00:15 [entrez] AID - 10.1038/s41366-026-02233-w [pii] AID - 10.1038/s41366-026-02233-w [doi] PST - aheadofprint SO - Int J Obes (Lond). 2026 Oct 24. doi: 10.1038/s41366-026-02233-w. PMID- 42926060 OWN - NLM STAT- Publisher LR - 20261024 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) DP - 2026 Oct 24 TI - Prevalence of Sarcopenic Obesity and Agreement Between Bioelectrical Impedance Analysis and Dual-Energy X-ray Absorptiometry in Children with Idiopathic Nephrotic Syndrome: A Cross-Sectional Study. PG - 105206 LID - S2405-4577(26)02303-X [pii] LID - 10.1016/j.clnesp.2026.105206 [doi] AB - BACKGROUND AND AIMS: Sarcopenic obesity (SO) is an increasingly recognised nutritional complication of chronic paediatric disease. Children with idiopathic nephrotic syndrome (INS) are predisposed to adverse body composition changes from persistent proteinuria, relapses, and corticosteroid exposure, but the prevalence of SO in this population is unknown. We aimed to determine SO prevalence, characterise body composition and bone health by SO status, and assess agreement between bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) in children with INS. METHODS: This cross-sectional study enrolled 128 children aged 3-16 years with INS in complete remission. Sarcopenia was defined as fat-free mass index below the 25th percentile (Indian reference standards); obesity was defined by BMI and by DXA-derived fat mass index above the 99th percentile. SO was therefore defined on body composition criteria alone, without functional muscle assessment, and is referred to as body composition-defined SO. All participants underwent simultaneous DXA and BIA. Agreement was assessed using intraclass correlation coefficient, Bland-Altman analysis with formal testing for proportional bias, and Cohen's kappa, with Pearson correlation reported descriptively. Because the Indian reference datasets do not span the full age range enrolled, the primary analysis was repeated in the subgroup covered by both references (6.0-15.0 years, n = 92). RESULTS: Sarcopenia was present in 46.9% (60/128) and obesity in 14.1% (BMI) versus 43.0% (DXA). SO occurred in 17.2% (22/128; 95% CI 10.6-23.8) by DXA criteria; no child met BMI-based SO criteria. In the subgroup covered by both reference datasets, SO prevalence was 13.0% (12/92; 95% CI 6.2-19.9). Children with SO were younger, with shorter disease duration, fewer relapses, and lower corticosteroid dose, and had lower whole-body BMC and BMD (both p < 0.001) despite comparable BMD Z-scores; these absolute bone differences did not persist after adjustment for age and height. BIA correlated strongly with DXA for fat-free mass (r = 0.964) and fat mass (r = 0.943) but systematically underestimated fat mass (mean bias -3.38 kg) and body fat percentage (-11.24%) and overestimated fat-free mass (+2.75 kg), with significant proportional bias for every compartment (all p < 0.001) and 0% sensitivity for DXA-confirmed SO (0/22; 95% CI 0.0-15.4). CONCLUSIONS: Body composition-defined SO affected roughly one in six children with INS in remission and was not detected by BMI. Within this cohort, across device and operational thresholds, BIA ranked continuous body composition well but did not reproduce the DXA-based SO classification. These estimates apply to body composition-defined SO and require confirmation in longitudinal, multicentre cohorts incorporating muscle function testing. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Punia, Simran AU - Punia S AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: simranpunia2226@gmail.com. FAU - Dawman, Lesa AU - Dawman L AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: lesadawman@gmail.com. FAU - Kaur, Harvinder AU - Kaur H AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: harvinderkaur315@gmail.com. FAU - Singh, Tulika AU - Singh T AD - Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: tulikardx@gmail.com. FAU - Yadav, Jaivinder AU - Yadav J AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: jai1984yadav@gmail.com. FAU - Vallabhaneni, Pujitha AU - Vallabhaneni P AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: vallabhanenipujitha143@gmail.com. FAU - Sadasivam, Deepthika AU - Sadasivam D AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: ss.deepthika@gmail.com. FAU - Mahajan, Shailza AU - Mahajan S AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: drshailzamahajan35@gmail.com. FAU - Tiewsoh, Karalanglin AU - Tiewsoh K AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: ktiewsoh@rediffmail.com. LA - eng PT - Journal Article DEP - 20261024 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM OTO - NOTNLM OT - Bioelectrical impedance analysis OT - body composition OT - dual-energy X-ray absorptiometry OT - idiopathic nephrotic syndrome OT - paediatric OT - sarcopenic obesity EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:36 CRDT- 2026/10/24 19:30 PHST- 2026/06/28 00:00 [received] PHST- 2026/10/02 00:00 [revised] PHST- 2026/10/18 00:00 [accepted] PHST- 2026/10/25 03:36 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 19:30 [entrez] AID - S2405-4577(26)02303-X [pii] AID - 10.1016/j.clnesp.2026.105206 [doi] PST - aheadofprint SO - Clin Nutr ESPEN. 2026 Oct 24:105206. doi: 10.1016/j.clnesp.2026.105206. PMID- 42925329 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261027 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 24 TI - Serum Netrin-1 and ultrasonographic hepatic steatosis severity in obese children and adolescents with metabolic dysfunction-associated steatotic liver disease: a preliminary study. LID - 887 [pii] LID - 10.1007/s00431-026-07566-2 [doi] AB - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a frequent hepatic complication of pediatric obesity, yet non-invasive circulating biomarkers associated with ultrasonographic steatosis severity remain limited. Netrin-1 is an immunometabolic regulator implicated in obesity-related inflammation and lipid metabolism, but prospective pediatric data in MASLD are scarce. In this preliminary prospective case-control study, 44 children and adolescents with obesity-related MASLD and 44 age- and sex-matched healthy controls with normal BMI were enrolled. Hepatic steatosis was assessed by ultrasonography, and serum Netrin-1 concentrations were measured by ELISA. Associations with ultrasonographic steatosis grade were evaluated using regression analyses, and discriminatory performance for moderate-to-severe ultrasonographic steatosis, defined as grades 2-3, was explored by receiver operating characteristic (ROC) analysis. Serum Netrin-1 concentrations were significantly higher in children and adolescents with obesity-related MASLD than in healthy controls with normal BMI (633.9 vs 302.0 pg/mL; p < 0.001). Within the MASLD group, Netrin-1 concentrations were higher in participants with grade 2-3 steatosis than in those with grade 1 steatosis (828.9 vs 594.7 pg/mL; p < 0.001). Netrin-1 correlated positively with alanine aminotransferase (rho = 0.669; p < 0.001). ROC analysis showed good discriminatory performance for moderate-to-severe ultrasonographic steatosis (AUC 0.827; 95% CI 0.699-0.955). CONCLUSION: These preliminary findings suggest that serum Netrin-1 may represent an exploratory complementary biomarker candidate associated with ultrasonographic steatosis severity in pediatric MASLD. Larger multicenter studies including children and adolescents with obesity but without steatosis, together with quantitative imaging-based assessment, are required to validate these associations and determine the incremental clinical value of serum Netrin-1. WHAT IS KNOWN: * Pediatric MASLD lacks validated non-invasive circulating biomarkers for assessing hepatic steatosis severity. * Netrin-1 is an immunometabolic mediator implicated in obesity-related inflammation and lipid metabolism, but pediatric data in MASLD are scarce. WHAT IS NEW: * In this preliminary prospective case-control study, serum Netrin-1 concentrations were higher in children and adolescents with obesity-related MASLD and were higher in those with grade 2-3 ultrasonographic steatosis than in those with grade 1 steatosis. * Serum Netrin-1 showed good exploratory discriminatory performance for moderate-to-severe ultrasonographic steatosis, suggesting that it may represent a complementary biomarker candidate requiring validation in larger independent pediatric cohorts. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Ozyilmaz, Leyla Gizem Bolac AU - Ozyilmaz LGB AUID- ORCID: 0000-0001-9056-080X AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. gizembolac@gmail.com. FAU - Inan, Ertugrul AU - Inan E AUID- ORCID: 0000-0001-5802-0467 AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. FAU - Ozdemir Akgun, Sevgi AU - Ozdemir Akgun S AUID- ORCID: 0000-0002-3053-8261 AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. FAU - Ozyilmaz, Safa AU - Ozyilmaz S AUID- ORCID: 0009-0002-2041-1037 AD - Department of Radiology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Cakir, Aydilek Dagdeviren AU - Cakir AD AUID- ORCID: 0000-0001-7136-9241 AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. FAU - Ucar, Ahmet AU - Ucar A AUID- ORCID: 0000-0001-8144-8437 AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20261024 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 158651-98-0 (Netrin-1) RN - 0 (Biomarkers) RN - 0 (NTN1 protein, human) SB - IM MH - Humans MH - *Netrin-1/blood MH - Male MH - Female MH - Adolescent MH - Child MH - Prospective Studies MH - Case-Control Studies MH - Biomarkers/blood MH - Ultrasonography MH - Severity of Illness Index MH - *Fatty Liver/blood/diagnostic imaging/etiology MH - *Pediatric Obesity/complications/blood MH - ROC Curve MH - Enzyme-Linked Immunosorbent Assay MH - *Non-alcoholic Fatty Liver Disease/blood/diagnostic imaging/etiology OTO - NOTNLM OT - Adolescents OT - Biomarkers OT - Children OT - Hepatic steatosis OT - MASLD OT - Netrin-1 COIS- Declarations. Ethical approval: This study protocol was reviewed and approved by the Institutional Ethics Committee of the University of Health Sciences Hamidiye Etfal Training and Research Hospital (Istanbul, Turkey), approval number 4158 (November 7, 2023). The study was conducted in accordance with the principles of the Declaration of Helsinki and its later amendments. Written informed consent was obtained from the parents or legal guardians of all participants before study enrollment. In addition, written assent was obtained from children aged 12 years and older, in accordance with institutional ethical requirements. Consent to participate: Written informed consent to participate in the study was obtained from the parents or legal guardians of all participants. In addition, written assent was obtained from children aged 12 years and older, in accordance with institutional and ethical guidelines. Conflict of interest: The authors declare no competing interests. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 CRDT- 2026/10/24 12:34 PHST- 2026/07/01 00:00 [received] PHST- 2026/10/20 00:00 [accepted] PHST- 2026/08/03 00:00 [revised] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 12:34 [entrez] AID - 10.1007/s00431-026-07566-2 [pii] AID - 10.1007/s00431-026-07566-2 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 24;185(11):887. doi: 10.1007/s00431-026-07566-2. PMID- 42925112 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 2531-0437 (Electronic) IS - 2531-0429 (Linking) VI - 32 IP - 1 DP - 2026 Dec TI - Six-minute walk distance reference values using a 15-metre course: A pragmatic study for resource-constrained settings. PG - 2751770 LID - 10.1080/25310429.2026.2751770 [doi] AB - BACKGROUND: The six-minute walk test (6MWT) is a simple, widely used measure of functional exercise capacity in children. Standard protocols recommend a 30-meter walking course; however, this is often impractical in routine clinical settings, particularly in resource-limited environments. Normative data for Indian children, especially younger age groups and under pragmatic testing conditions, remain limited. OBJECTIVES: To establish age- and sex-specific reference values for six-minute walk distance (6MWD) in apparently healthy Indian children aged 4-14 years using a pragmatic 15-meter walking course and evaluate associations with anthropometric variables. METHODS: In this community-based cross-sectional study, 400 healthy school-going children underwent the 6MWT using a standardized 15-meter indoor course. Anthropometric and baseline physiological parameters were recorded. Percentile reference values were generated, and multivariable linear regression was performed to identify determinants of 6MWD and derive a predictive equation. RESULTS: Mean (SD) 6MWD was 365.3 (50.8) meters. Distance increased significantly with age, height, weight, and body mass index (all p<0.001). After adjustment, no independent sex-based differences were observed. The predictive equation was: 6MWD = 279.5 + 8.6 x age (years) + 2.7 x weight (kg) - 5.0 x BMI (kg/m(2)) (R(2) = 0.62). No significant differences were observed by residence or school type. CONCLUSIONS: This study provides 15-meter course-specific reference values for 6MWD in healthy Indian children aged 4-14 years. The derived predictive equation may assist interpretation of 6MWD obtained using this protocol; however, external validation and direct comparison with the standard 30-meter course are required before broader application, where longer courses are not feasible. FAU - Jaladi, Harini Chowdary AU - Jaladi HC AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Gulla, Krishna Mohan AU - Gulla KM AUID- ORCID: 0000-0001-5031-5754 AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Das, Rashmi Ranjan AU - Das RR AUID- ORCID: 0000-0001-9587-0508 AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Behera, Binod Kumar AU - Behera BK AUID- ORCID: 0000-0001-8113-5289 AD - Department of Community Medicine & Family Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Nayak, Saurav AU - Nayak S AUID- ORCID: 0000-0003-2394-295X AD - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Dwibedi, Bhagirathi AU - Dwibedi B AUID- ORCID: 0000-0002-5318-6836 AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. LA - eng PT - Journal Article DEP - 20261023 PL - United States TA - Pulmonology JT - Pulmonology JID - 101723786 SB - IM MH - Humans MH - Child MH - Male MH - Adolescent MH - Reference Values MH - Child, Preschool MH - Cross-Sectional Studies MH - *Walk Test/methods/standards MH - Female MH - India MH - *Walking/physiology MH - *Exercise Tolerance/physiology MH - Age Factors MH - Body Mass Index OTO - NOTNLM OT - Six-minute walk test OT - exercise tolerance OT - field walking test OT - functional exercise capacity OT - paediatric population EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 CRDT- 2026/10/24 12:22 PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 12:22 [entrez] AID - 10.1080/25310429.2026.2751770 [doi] PST - ppublish SO - Pulmonology. 2026 Dec;32(1):2751770. doi: 10.1080/25310429.2026.2751770. Epub 2026 Oct 23. PMID- 42924704 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261026 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 4 DP - 2026 Oct 16 TI - Psychometric Properties of the French Version of the Physical Literacy in Children Questionnaire (PL-C Quest). LID - 10.3390/jfmk11040425 [doi] LID - 425 AB - Background and Objectives: The main objective of this study was to examine the psychometric properties of a French adaptation of the Physical Literacy in Children Questionnaire (PL-C Quest). Methods: A sample of 196 French-speaking Canadian and French children (aged 5 to 12 years) participated in this study. Results: Matching the results from several previous studies, our results failed to support the adequacy of the a priori four-factor and hierarchical structure of the PL-C Quest. However, results from an exploratory factor analytic solution supported a 3-factor, 13-item solution of the PL-C Quest measuring (a) Physical Competencies; (b) Motivation and Enjoyment to be Physically Active; and (c) Self-Regulation, Risk, and Safety. Subsequent analyses revealed a lack of differential item functioning (DIF) as function of countries and children's time spent in moderate to vigorous physical activities (MVPA) providing preliminary support for the comparability of scores across these groups. However, some limited evidence of DIF was found as function of children's age (on one item), body mass-index (on two items) and sex (on one item). Furthermore, latent mean differences (favoring younger children and boys) were identified in (a) Self-Regulation, Risk, and Safety and (b) Physical Competencies as function of children's age and sex, respectively. These findings should be interpreted cautiously and warrant replication in independent samples. Finally, results provided preliminary evidence for the convergent validity of the 13-item French version of the PL-C Quest in relation to parental ratings of children's overall, cognitive, and motor physical literacy. Conclusions: Scores on the new 13-item French version of the PL-C Quest present acceptable psychometric properties in terms of composite reliability, factor validity, and minimal DIF, alongside preliminary support for convergent validity. FAU - Maiano, Christophe AU - Maiano C AUID- ORCID: 0000-0002-4764-2209 AD - Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais, Saint-Jerome, QC J7Z 0B7, Canada. AD - Cyberpsychology Laboratory, Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais, Gatineau, QC J8X 3X7, Canada. AD - Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. FAU - Morin, Alexandre J S AU - Morin AJS AUID- ORCID: 0000-0001-6898-4788 AD - Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. AD - Optentia Research Unit, North-West University, P.O. Box 1174, Vanderbijlpark 1900, South Africa. FAU - April, Johanne AU - April J AD - Department of Educational Sciences, Universite du Quebec en Outaouais, Saint-Jerome, QC J7Z 0B7, Canada. FAU - Hue, Olivier AU - Hue O AUID- ORCID: 0000-0001-9270-5291 AD - Department of Physical Activity Sciences, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC G9A 5H7, Canada. FAU - Rey, Olivier AU - Rey O AD - Institute of Movement Sciences, Centre National de la Recherche Scientifique, Aix Marseille University, 13288 Marseille Cedex 09, France. LA - eng GR - 633-2022-00060/Social Sciences and Humanities Research Council/ PT - Journal Article DEP - 20261016 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13692324 OTO - NOTNLM OT - French OT - age OT - body mass index OT - differential item functioning OT - physical activity OT - physical literacy OT - sex COIS- The authors declare no conflicts of interest. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/10/16 CRDT- 2026/10/24 12:07 PHST- 2026/08/27 00:00 [received] PHST- 2026/09/21 00:00 [revised] PHST- 2026/10/08 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 12:07 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - jfmk11040425 [pii] AID - jfmk-11-00425 [pii] AID - 10.3390/jfmk11040425 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Oct 16;11(4):425. doi: 10.3390/jfmk11040425. PMID- 42924692 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261026 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 4 DP - 2026 Oct 8 TI - Musculoskeletal Findings Following Pre-Participation Screening in Young Athletes: A Retrospective Observational Study. LID - 10.3390/jfmk11040413 [doi] LID - 413 AB - Background: Pre-participation screening (PPS) is widely used to evaluate athletes before sport participation, traditionally focusing on cardiovascular risk prevention. However, musculoskeletal assessment performed during PPS may also allow early identification of biomechanical and structural abnormalities that can affect sport participation during growth. Objectives: This study aimed to describe the prevalence, clinical characteristics, and management pathways of musculoskeletal alterations detected during PPS in young athletes, with particular focus on referral patterns to pediatric Physical Medicine and Rehabilitation (PM&R) specialists. Methods: This retrospective observational study included athletes aged /=3 years of experience) were allocated to an experimental group (EG; n = 12) or control group (CG; n = 12). The EG performed a 12-week technology-assisted neuromuscular training program (BlazePod light-sensor system) before each session; the CG continued standard uchi-komi. Three outcome domains were assessed at baseline and post-intervention: (i) judo-specific anaerobic fitness (SJFT); (ii) specific shuttle agility (BlazePod protocol); and (iii) static plantar pressure (BTS P-WALK baropodometer). Results: Retention was 100% with no adverse events. A 2 x 2 mixed-design ANOVA (group x time) showed a significant interaction for BlazePod shuttle agility performance (total hits: p = 0.026; average sprint time: p = 0.009), an effect that remained significant after a sensitivity analysis controlling for baseline anthropometric imbalance between groups. A significant interaction was also observed for the SJFT index (p = 0.028), but this effect did not survive the same sensitivity analysis (p = 0.10). No significant group x time interaction was detected for any of the six static plantar pressure regions assessed (all p > 0.09). Conclusions: In this pilot study, feasibility was supported by 100% retention and the absence of reported adverse events. The data provided preliminary evidence of a group x time interaction for judo-specific shuttle agility performance that remained significant after adjustment for baseline anthropometric imbalance, a less certain interaction for anaerobic fitness, and no detectable interaction for static plantar pressure distribution. These preliminary, hypothesis-generating findings support conducting a definitive, randomized, weight-stratified controlled trial. FAU - Nagy, Alpar AU - Nagy A AD - Doctoral School of Physical Education and Sport, Babes-Bolyai University, 400015 Cluj-Napoca, Romania. AD - "Activ Judo" Sports Club, 405100 Campia Turzii, Romania. FAU - Ordean, Mircea Nicolae AU - Ordean MN AD - Department of Physical Education and Sport, University "1 Decembrie 1918", 510009 Alba Iulia, Romania. FAU - Grosu, Vlad Teodor AU - Grosu VT AUID- ORCID: 0000-0002-4846-4491 AD - Department of Mechatronics and Machine Dynamics, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania. FAU - Mancini, Nicola AU - Mancini N AUID- ORCID: 0009-0005-4566-6417 AD - Department of Education and Sport Sciences, Pegaso Telematic University, 80143 Naples, Italy. FAU - Mancini, Siria AU - Mancini S AUID- ORCID: 0009-0003-5584-6409 AD - Department of Experimental and Clinical Medicine, University of Foggia, 71121 Foggia, Italy. FAU - Neagu, Sonia Gabriela AU - Neagu SG AUID- ORCID: 0009-0000-3064-5537 AD - Faculty of Sciences, Physical Education and Sport, "Lucian Blaga" University of Sibiu, 550012 Sibiu, Romania. FAU - Grosu, Emilia Florina AU - Grosu EF AUID- ORCID: 0000-0002-2846-9586 AD - Doctoral School of Physical Education and Sport, Babes-Bolyai University, 400015 Cluj-Napoca, Romania. FAU - Aducovschi, Daniela AU - Aducovschi D AUID- ORCID: 0000-0001-7178-0786 AD - Department of Physical Education and Sport, University of Bucharest, 010041 Bucharest, Romania. FAU - Sabau, Anca Maria AU - Sabau AM AD - Department of Physical Education, Sport and Physiotherapy, University of Oradea, 410087 Oradea, Romania. FAU - Mihaiu, Costinel AU - Mihaiu C AUID- ORCID: 0009-0007-0897-0780 AD - Department of Physical Education and Sport, University of Bucharest, 010041 Bucharest, Romania. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13692397 OTO - NOTNLM OT - Special Judo Fitness Test OT - adolescent athletes OT - baropodometry OT - ippon-seoi-nage OT - judo OT - kuzushi OT - neuromuscular training OT - pilot study OT - plantar pressure OT - shuttle agility COIS- The authors declare no conflicts of interest. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/10/01 CRDT- 2026/10/24 12:07 PHST- 2026/08/19 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 12:07 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - jfmk11040399 [pii] AID - jfmk-11-00399 [pii] AID - 10.3390/jfmk11040399 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Oct 1;11(4):399. doi: 10.3390/jfmk11040399. PMID- 42924536 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 1520-6300 (Electronic) IS - 1042-0533 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Determinants of Stunting, Wasting, and Underweight Among Indonesian Children Under Five: A Complex Survey Analysis of the 2024 Indonesian Nutritional Status Survey. LID - e70355 [pii] LID - 10.1002/ajhb.70355 [doi] AB - OBJECTIVES: Stunting, wasting, and underweight are widely used anthropometric indicators of child growth in Indonesia, but they are often equated with undernutrition although they also reflect social, economic, and other contextual conditions. We estimated their national prevalence and tested whether maternal, pregnancy, child health, and health-service factors are associated with each indicator among children aged 0-59 months. METHODS: We conducted a cross-sectional secondary analysis of the 2024 Indonesian Nutritional Status Survey (SSGI), a nationally representative multistage complex survey. Among 300 143 children with valid anthropometric data, height/length-for-age, weight-for-age, and weight-for-height/length z-scores were calculated using the World Health Organization (WHO) Child Growth Standards. Weighted logistic regression with primary sampling unit-clustered robust standard errors was used to estimate adjusted odds ratios (AORs) and 95% confidence intervals (CIs). Collinearity among covariates was assessed with variance inflation factors. RESULTS: Weighted prevalence was 20.4% for stunting (4.4% severe), 16.9% for underweight, and 7.4% for wasting. Maternal age < 20 years at conception was associated with stunting (AOR 1.50), underweight (AOR 1.46), and wasting (AOR 1.12). Recent diarrhea was associated with all three outcomes (AOR range 1.19-1.30). Attendance at four or more antenatal care visits (AOR range 0.66-0.75) and routine growth-monitoring attendance (AOR range 0.69-0.74) were associated with lower odds of all three outcomes. Rural residence was associated with higher odds of stunting (AOR 1.26) and underweight (AOR 1.17), but not wasting. CONCLUSIONS: Stunting, wasting, and underweight among Indonesian children were associated with maternal age, antenatal care, recent diarrhea, growth-monitoring attendance, and residence. Because household wealth, parental education, and dietary intake were not included in the models, these associations should not be read as evidence that nutrient intake explains the observed growth deficits, and residual socioeconomic and contextual confounding is likely. CI - (c) 2026 Wiley Periodicals LLC. FAU - Lubis, Anwar AU - Lubis A AUID- ORCID: 0000-0002-7984-8025 AD - Culinary Art Study Program, Department of Tourism and Hospitality, Faculty of Engineering, Universitas Negeri Makassar, Makassar, South Sulawesi, Indonesia. FAU - Ibrahim, Firmansyah AU - Ibrahim F AD - Department of Information Systems, Universitas Islam Negeri Alauddin Makassar, Makassar, Indonesia. FAU - Pratiwi, Hardyanti AU - Pratiwi H AD - Nutrition Study Program, Faculty of Medicine and Nutrition, IPB University, Bogor, Indonesia. AD - Nutrition Study Program, Faculty of Nursing and Midwifery, Megarezky University, Makassar, Indonesia. FAU - Jufrinaldi, Jufrinaldi AU - Jufrinaldi J AUID- ORCID: 0000-0001-7350-3651 AD - Chemical Engineering Study Program, Faculty of Engineering, Pamulang University, Tangerang, Banten, Indonesia. FAU - Arifuddin, R AU - Arifuddin R AD - BMBPSDM, Ministry of Religious Affairs, Central Jakarta, Indonesia. LA - eng PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Indonesia/epidemiology MH - *Thinness/epidemiology/etiology MH - *Growth Disorders/epidemiology/etiology MH - Female MH - Cross-Sectional Studies MH - Prevalence MH - *Wasting Syndrome/epidemiology/etiology MH - Infant MH - Child, Preschool MH - *Nutritional Status MH - Male MH - Infant, Newborn MH - Nutrition Surveys OTO - NOTNLM OT - Indonesia OT - child growth OT - socioeconomic context OT - stunting OT - underweight OT - wasting EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 CRDT- 2026/10/24 11:59 PHST- 2026/10/14 00:00 [revised] PHST- 2026/09/26 00:00 [received] PHST- 2026/10/16 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 11:59 [entrez] AID - e70355 [pii] AID - 10.1002/ajhb.70355 [doi] PST - ppublish SO - Am J Hum Biol. 2026 Oct;38(10):e70355. doi: 10.1002/ajhb.70355. PMID- 42923491 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261025 IS - 1943-8141 (Print) IS - 1943-8141 (Electronic) IS - 1943-8141 (Linking) VI - 18 IP - 9 DP - 2026 TI - Risk factor for impaired lung function in asthmatic children: predictive value of 25-OH-D, BMI and inflammatory markers. PG - 7799-7809 LID - 10.62347/KKJG5734 [doi] AB - OBJECTIVE: This cross-sectional study investigated the associations between modifiable metabolic risk factors (vitamin D status and obesity) and pulmonary function decline in children with asthma, independent of disease duration and airway inflammation. METHODS: Medical records of 430 asthmatic children (aged /=25 kg/m(2), n = 5). CONCLUSIONS: High retention, adherence, and acceptability suggest TRE in youth with T1D is feasible; however, the low enrollment rate questions feasibility. Low rates of hypoglycemia suggest safety. These findings will inform larger TRE trials in youth with T1D. CI - (c) 2026 by the American Diabetes Association. FAU - Berman, Casey M AU - Berman CM AUID- ORCID: 0000-0003-2045-4213 AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Vidmar, Alaina P AU - Vidmar AP AD - Children's Hospital Los Angeles, Los Angeles, CA. AD - Keck School of Medicine, University of Southern California, Los Angeles, CA. FAU - Flores Garcia, Jaquelin AU - Flores Garcia J AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Reid, Mark W AU - Reid MW AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Gonzalez, Frances AU - Gonzalez F AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Torres Sanchez, Alejandra AU - Torres Sanchez A AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Salcedo-Rodriguez, Elizabeth AU - Salcedo-Rodriguez E AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Raymond, Jennifer K AU - Raymond JK AD - Children's Hospital Los Angeles, Los Angeles, CA. AD - Keck School of Medicine, University of Southern California, Los Angeles, CA. LA - eng PT - Journal Article DEP - 20260915 PL - United States TA - Diabetes Obes Cardiometab CARE JT - Diabetes, obesity, and cardiometabolic CARE JID - 9919229522706676 PMC - PMC13687448 COIS- No potential conflicts of interest relevant to this article were reported. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/09/15 CRDT- 2026/10/24 10:39 PHST- 2026/01/15 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 10:39 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - 250087 [pii] AID - 10.2337/doc25-0087 [doi] PST - epublish SO - Diabetes Obes Cardiometab CARE. 2026 Sep 15;1(5):849-857. doi: 10.2337/doc25-0087. eCollection 2026 Sep-Oct. PMID- 42922781 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261025 IS - 2237-9622 (Electronic) IS - 1679-4974 (Print) IS - 1679-4974 (Linking) VI - 35 DP - 2026 TI - Performance of anthropometric indices in early detection of diabetes and prediabetes in the Brazilian population: a cross-sectional study, Brazil, 2013. PG - e20240606 LID - 10.1590/S2237-96222026v35e20240606.en [doi] LID - e20240606 AB - OBJECTIVE: To assess the diagnostic performance of anthropometric adiposity metrics for diabetes and prediabetes detection in Brazilian adults. METHODS: This was a cross-sectional study using data from national surveys, such as glycated hemoglobin laboratory test data. Diabetes was defined as glycated hemoglobin >/=6.5% or when hypoglycemic agents were being taken; prediabetes was defined as glycated hemoglobin >/=5.7% and <6.5%. Diabetes and prediabetes prevalence rates were estimated with 95% confidence intervals (95%CI). The diagnostic performance of anthropometric indices - body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHR), and body shape index - were evaluated using the area under the ROC curve (AUC), sensitivity, specificity, positive and negative predictive value, and Youden's index, stratified by sex and age group. RESULTS: 8,435 individuals participated in the study. Diabetes prevalence was 8.6% (95%CI 7.8; 9.3), while prediabetes prevalence was 16.2% (95%CI 15.1; 17.3). In males <40 years old, the AUC for the anthropometric indices was close to 0.5; among males between 40 and 59 years old, it ranged from 0.66 to 0.71; in older males, the AUC for WC was 0.72. Among females <40 years old, the WHR AUC was 0.77; for those between 40 and 59 years old, it ranged from 0.64 to 0.69; and in older females, the WC AUC was 0.66. The AUCs were lower for prediabetes: in males, they ranged from 0.58 to 0.63; while in females they ranged from 0.60 to 0.65. CONCLUSION: WC was the index with the best performance for differentiating individuals with diabetes, while the ROC curve showed greater accuracy among adults <60 years old. FAU - Tonaco, Luis Antonio Batista AU - Tonaco LAB AUID- ORCID: 0000-0001-9660-2900 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. FAU - Felisbino-Mendes, Mariana Santos AU - Felisbino-Mendes MS AUID- ORCID: 0000-0001-5321-5708 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. FAU - Moreira, Alexandra Dias AU - Moreira AD AUID- ORCID: 0000-0002-4477-5241 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. FAU - Romeiro, Amanda Maria de Sousa AU - Romeiro AMS AUID- ORCID: 0000-0002-6769-3978 AD - Universidade Federal de Goias, Faculdade de Medicina, Goiania, GO, Brazil Universidade Federal de Goias Faculdade de Medicina GoianiaGO Brazil. FAU - Silveira, Erika Aparecida AU - Silveira EA AUID- ORCID: 0000-0002-8839-4520 AD - Universidade Federal de Goias, Faculdade de Medicina, Goiania, GO, Brazil Universidade Federal de Goias Faculdade de Medicina GoianiaGO Brazil. FAU - Souza, Maria Jose Silva AU - Souza MJS AUID- ORCID: 0000-0002-1640-7441 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. FAU - Velasquez-Melendez, Gustavo AU - Velasquez-Melendez G AUID- ORCID: 0000-0001-8349-5042 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. LA - eng LA - por PT - Journal Article DEP - 20260704 PL - Brazil TA - Epidemiol Serv Saude JT - Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil JID - 101248287 RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *Prediabetic State/diagnosis/epidemiology MH - Cross-Sectional Studies MH - Female MH - Brazil/epidemiology MH - Male MH - Middle Aged MH - *Diabetes Mellitus/diagnosis/epidemiology MH - Adult MH - Prevalence MH - Body Mass Index MH - ROC Curve MH - Sensitivity and Specificity MH - Early Diagnosis MH - Waist Circumference/physiology MH - Glycated Hemoglobin/metabolism/analysis MH - Young Adult MH - Aged MH - Predictive Value of Tests MH - *Anthropometry MH - Area Under Curve MH - Adolescent PMC - PMC13686399 OTO - NOTNLM OT - Anthropometry. OT - Cross-Sectional Studies OT - Diabetes Mellitus OT - Prediabetic State OT - ROC Curve COIS- Conflict of interest : None to declare. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/07/04 CRDT- 2026/10/24 10:22 PHST- 2025/09/16 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 10:22 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - 10.1590/S2237-96222026v35e20240606.en [doi] PST - epublish SO - Epidemiol Serv Saude. 2026 Jul 4;35:e20240606. doi: 10.1590/S2237-96222026v35e20240606.en. eCollection 2026. PMID- 42922747 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261025 IS - 2237-9622 (Electronic) IS - 1679-4974 (Print) IS - 1679-4974 (Linking) VI - 35 DP - 2026 TI - Self-reported fruit and vegetable intake obtained through a brief telephone interview among users of the Academia da Saude Program: a validation study, Belo Horizonte, Minas Gerais, Brazil, 2016-2017. PG - e20250817 LID - 10.1590/S2237-96222026v35e20250817.en [doi] LID - e20250817 AB - OBJECTIVE: To assess the validity of fruit and vegetable intake data among users of a health promotion service of the Brazilian Unified Health System (Sistema Unico de Saude, SUS). METHODS: Validation study conducted between 2016 and 2017 in the Health Academy Program (Programa Academia da Saude) in Belo Horizonte, Minas Gerais, Brazil. Fruit and vegetable intake was estimated using a brief questionnaire administered in a telephone interview and validated through face-to-face interviews. For statistical analyses of the total sample and the sex-stratified sample, one-sample t-tests, the Concordance Correlation Coefficient (CCC), Bland-Altman plots, and limits of agreement were used. RESULTS: A total of 441 respondents were included, of whom 378 (85.7%) were women, and 255 (57.8%) were adults. After stratification by sex, the differences between methods were equal to zero. Agreement between the methods was substantial for fruit intake (CCC ranging from 0.632 to 0.696), and low to moderate for vegetable intake (CCC ranging from 0.397 to 0.500). When stratified by education level, the differences were not equal to zero, but there was moderate-to-substantial agreement between the methods for fruit intake (CCC ranging from 0.572 to 0.766) and moderate agreement for vegetable intake (CCC ranging from 0.405 to 0.513). The Bland-Altman plots showed that the differences between the methods were centered around zero and remained stable at higher intake levels. CONCLUSION: Data obtained from telephone interviews were valid for estimating fruit and vegetable intake among SUS users. FAU - de Carvalho, Maria Cecilia Ramos AU - de Carvalho MCR AUID- ORCID: 0000-0002-8947-2121 AD - Universidade Federal de Minas Gerais, Grupo de Pesquisa de Intervencoes em Nutricao, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Grupo de Pesquisa de Intervencoes em Nutricao Belo HorizonteMG Brazil. FAU - Lopes, Mariana Souza AU - Lopes MS AUID- ORCID: 0000-0003-3128-7959 AD - Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil Universidade Federal da Paraiba Departamento de Nutricao Joao PessoaPB Brazil. FAU - de Freitas, Patricia Pinheiro AU - de Freitas PP AUID- ORCID: 0000-0001-9355-3066 AD - Universidade Federal dos Vales do Jequitinhonha e Mucuri, Departamento de Nutricao, Diamantina, MG, Brazil Universidade Federal dos Vales do Jequitinhonha e Mucuri Departamento de Nutricao DiamantinaMG Brazil. FAU - Lopes, Aline Cristine Souza AU - Lopes ACS AUID- ORCID: 0000-0001-9782-2606 AD - Universidade Federal de Minas Gerais, Departamento de Nutricao, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento de Nutricao Belo HorizonteMG Brazil. LA - eng LA - por PT - Journal Article PT - Validation Study DEP - 20260624 PL - Brazil TA - Epidemiol Serv Saude JT - Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil JID - 101248287 SB - IM MH - Humans MH - Brazil MH - *Fruit MH - *Vegetables MH - Female MH - Male MH - Adult MH - Interviews as Topic MH - *Self Report MH - Middle Aged MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Young Adult MH - Telephone MH - Health Promotion/methods MH - *Diet/statistics & numerical data MH - Adolescent PMC - PMC13686308 OTO - NOTNLM OT - Eating OT - Fruit OT - Nutritional Assessment OT - Validation Study OT - Vegetables COIS- Conflict of interest: None to declare. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/06/24 CRDT- 2026/10/24 10:19 PHST- 2025/08/01 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 10:19 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1590/S2237-96222026v35e20250817.en [doi] PST - epublish SO - Epidemiol Serv Saude. 2026 Jun 24;35:e20250817. doi: 10.1590/S2237-96222026v35e20250817.en. eCollection 2026. PMID- 42921903 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 1399-3046 (Electronic) IS - 1397-3142 (Linking) VI - 30 IP - 10 DP - 2026 Oct TI - The Relationship Between Estimated and Measured Glomerular Filtration Rate in Pediatric Hematopoietic Stem Cell Transplant Candidates. LID - e70507 [pii] LID - 10.1111/petr.70507 [doi] AB - BACKGROUND: Accurate assessment of renal function through glomerular filtration rate (GFR) is a vital parameter in determining eligibility for hematopoietic stem cell transplantation (HSCT), as conditioning regimens often include nephrotoxic agents. Technetium-99 m diethylenetriaminepentaacetic acid (Tc-99m DTPA) nuclear scans are commonly used to measure GFR, but creatinine-based formulas may be more convenient and cost-effective. This study compared three contemporary creatinine-based equations, the bedside Schwartz, Full Age Spectrum (FAS), and CKiD U25 creatinine equations with the Tc-99 m DTPA measured GFR (mGFR) in pediatric HSCT candidates. MATERIALS AND METHODS: This retrospective cohort included 100 transplant episodes in pediatric patients undergoing autologous or allogeneic HSCT at King Abdulaziz Medical City, Jeddah. Agreement was evaluated using mean bias, standard deviation of the differences (precision), 95% limits of agreement, root-mean-square error, P10, P30, Lin's concordance correlation coefficient, and Bland-Altman analyses using both absolute and percentage differences. Exploratory subgroup analyses were conducted by sex and transplant type. RESULTS: The cohort included 59 male and 41 female transplant episodes; 57 were autologous and 43 were allogeneic. Mean Tc-99 m DTPA mGFR was 113.0 mL/min/1.73 m(2). Mean eGFR values were 112.4 for Schwartz, 102.2 for FAS, and 98.3 mL/min/1.73 m(2) for U25. Schwartz had the smallest mean absolute bias (-0.6 mL/min/1.73 m(2)) but poor concordance (CCC 0.19), wide limits of agreement (-57.8 to 56.6), P10 of 27%, and P30 of 76%. FAS and U25 showed systematic underestimation, with biases of -11.0 and -14.7 mL/min/1.73 m(2), respectively. Root-mean-square error was 29.0, 30.2, and 31.7 mL/min/1.73 m(2) for Schwartz, FAS, and U25, respectively. Performance remained limited across sex and transplant-type subgroups. CONCLUSION: None of the three creatinine-based equations demonstrated sufficient individual-level agreement with Tc-99 m DTPA mGFR to replace measured GFR in pediatric HSCT candidates. Schwartz showed minimal average bias but substantial imprecision, whereas FAS and U25 tended to underestimate mGFR. Creatinine-based eGFR remains useful for routine monitoring, but radionuclide measurement should be retained when precise renal assessment may affect transplant eligibility or nephrotoxic drug dosing. CI - (c) 2026 Wiley Periodicals LLC. FAU - Monagel, Dania A AU - Monagel DA AUID- ORCID: 0000-0002-0469-6733 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. AD - Department of Pediatric Oncology, Ministry of the National Guard- Health Affairs, Jeddah, Saudi Arabia. FAU - Altaf, Wid F AU - Altaf WF AUID- ORCID: 0009-0001-9712-5437 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Bokhari, Maya F AU - Bokhari MF AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Afif, Afnan Bin AU - Afif AB AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Alaslab, Alanoud K AU - Alaslab AK AUID- ORCID: 0009-0008-8307-4756 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Bamehriz, Amal M AU - Bamehriz AM AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Alidreesi, Kinan A AU - Alidreesi KA AUID- ORCID: 0009-0009-4991-8190 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Althubaiti, Alaa AU - Althubaiti A AUID- ORCID: 0000-0002-4175-1703 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. LA - eng PT - Journal Article PL - Denmark TA - Pediatr Transplant JT - Pediatric transplantation JID - 9802574 RN - VW78417PU1 (Technetium Tc 99m Pentetate) RN - AYI8EX34EU (Creatinine) RN - 0 (Radiopharmaceuticals) SB - IM MH - Humans MH - *Glomerular Filtration Rate MH - *Hematopoietic Stem Cell Transplantation MH - Female MH - Male MH - Child MH - Retrospective Studies MH - Child, Preschool MH - Adolescent MH - Technetium Tc 99m Pentetate MH - Infant MH - Creatinine/blood MH - Radiopharmaceuticals MH - Kidney Function Tests/methods OTO - NOTNLM OT - Tc-99m diethylenetriaminepentaacetic acid4 OT - glomerular filtration rate2 OT - hematopoietic stem cell transplant1 OT - pediatrics3 OT - schwartz formula5 EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 CRDT- 2026/10/24 09:34 PHST- 2026/09/28 00:00 [revised] PHST- 2026/05/19 00:00 [received] PHST- 2026/10/03 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 09:34 [entrez] AID - e70507 [pii] AID - 10.1111/petr.70507 [doi] PST - ppublish SO - Pediatr Transplant. 2026 Oct;30(10):e70507. doi: 10.1111/petr.70507. PMID- 42921813 OWN - NLM STAT- Publisher LR - 20261024 IS - 1550-9109 (Electronic) IS - 0161-8105 (Linking) DP - 2026 Oct 24 TI - The Sleep-Wake Classification Performance of Pediatric-Trained Machine Learning Algorithms for Raw Accelerometer Data. LID - zsag282 [pii] LID - 10.1093/sleep/zsag282 [doi] AB - STUDY OBJECTIVES: Actigraphy sleep-wake classification methods increasingly seek to leverage raw acceleration data and machine-learning-based classification, but performance evaluation in pediatrics is limited. We trained machine-learning models using pediatric data and compared their sleep-wake classification performance with existing algorithms for children. METHODS: Sixty-five children (46% female, ages 5.3-17.7 years) completed in-lab overnight polysomnography and wore a GENEActiv device on their non-dominant wrist. The acceleration data were converted into 30-second epochs and aligned with physician-scored sleep-wake data from electroencephalography. Eight machine-learning models were trained using leave-one-subject-out cross-validation. Epoch-by-epoch analyses generated performance metrics (e.g., balanced accuracy [BA]) and discrepancy analyses provided overall sleep duration bias estimates. The combination of highest performance and least bias was used to rank using Euclidean distance scores - where a lower score represents closer to perfect performance and zero bias. For benchmarking, we included GGIR sleep scoring algorithms and an adult trained random forest classifier. RESULTS: Overall, 560.1 hours of polysomnography and actigraphy data were collected (74.4% of epochs were scored as sleep). The pediatric-trained local-global long-short term memory (LSTM) classifier had the most optimal epoch-by-epoch performance (e.g., BA=0.85, sensitivity=0.88, specificity=0.83, ROC-AUC=0.95, and Cohen's kappa=0.67). These metrics exceeded that of an adult-trained random forest classifier and GGIR-based algorithms. Discrepancy analyses revealed that overall sleep duration was underestimated by an average of 25 minutes using the LSTM classifier with no proportional bias. CONCLUSIONS: We trained eight pediatric sleep-wake classifiers that had a strong ability to detect sleep and wake, with the LSTM classifier being most optimal. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Sleep Research Society. FAU - Chen, Pin-Wei AU - Chen PW AUID- ORCID: 0000-0002-4394-1519 AD - Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Cielo, Christopher AU - Cielo C AUID- ORCID: 0000-0001-5761-6373 AD - Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA. AD - Division of Pulmonology and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Walch, Olivia AU - Walch O AD - Arcascope, Inc., Arlington, VA, USA. AD - Department of Neurology, School of Medicine, University of Michigan, Ann Arbor, MI, USA. FAU - McDonald, Morgan AU - McDonald M AD - Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Song, Peter X K AU - Song PXK AD - Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. FAU - Goldstein, Cathy AU - Goldstein C AD - Department of Neurology, School of Medicine, University of Michigan, Ann Arbor, MI, USA. FAU - Moreno, Jennette P AU - Moreno JP AUID- ORCID: 0000-0002-9372-6104 AD - Department of Pediatrics-Nutrition, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA. FAU - Jansen, Erica C AU - Jansen EC AUID- ORCID: 0000-0002-3364-3729 AD - Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI, USA. FAU - Mitchell, Jonathan A AU - Mitchell JA AD - Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA. AD - Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. LA - eng PT - Journal Article DEP - 20261024 PL - United States TA - Sleep JT - Sleep JID - 7809084 SB - IM OTO - NOTNLM OT - Actigraphy OT - Machine Learning OT - Pediatrics OT - Sleep-wake Classification OT - Validation study OT - Wearable Sensors EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:36 CRDT- 2026/10/24 08:34 PHST- 2026/06/12 00:00 [received] PHST- 2026/09/28 00:00 [revised] PHST- 2026/10/16 00:00 [accepted] PHST- 2026/10/25 03:36 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 08:34 [entrez] AID - 8996764 [pii] AID - 10.1093/sleep/zsag282 [doi] PST - aheadofprint SO - Sleep. 2026 Oct 24:zsag282. doi: 10.1093/sleep/zsag282. PMID- 42921283 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261026 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 10 DP - 2026 Oct TI - Beyond Observable Behavior: A Narrative Review of Integrated Clinical, Biological, and Functional Assessment in Children With Autism Spectrum Disorder. PG - e118440 LID - 10.7759/cureus.118440 [doi] LID - e118440 AB - Assessment of children with autism spectrum disorder must characterize everyday functioning, co-occurring conditions, and individual support needs alongside diagnostic classification. This narrative review examines the evidence and clinical rationale for integrated clinical, biological, and functional assessment in pediatric autism and presents SMART-NB as a proposed framework for organizing these dimensions. The review combines selected clinical guidelines and research publications with conceptual analysis and a targeted literature update, distinguishing established assessment principles from the author-developed framework. Three findings emerge. First, standardized observational instruments contribute to diagnosis but require interpretation alongside developmental history, caregiver information, differential diagnosis, and clinical judgment. Second, co-occurring sleep disturbances, gastrointestinal symptoms, nutritional problems, sensory impairments, and pain can influence behavior and participation and warrant clinically directed evaluation; their association with autism does not establish causation. Third, symptom severity does not fully describe adaptive functioning, supporting assessment across functional domains and everyday contexts. SMART-NB proposes connecting clinical, medical and biological, and demand-related profiles with seven functional domains, individualized goals, and longitudinal reassessment. The demand dimension examines available capacity, physiological and emotional burden, environmental requirements, and supports. Its proposed contribution is to document how assessment findings inform care priorities. Existing multidimensional approaches already address overlapping aspects of this task; the incremental value of this particular organization remains untested. The reviewed evidence supports multidimensional assessment but does not establish the validity, reliability, or clinical utility of SMART-NB. This review is not systematic, and extension beyond autism remains a hypothesis requiring condition-specific evaluation. Development should proceed from operational specification, independent content assessment, and feasibility studies to the evaluation of measurement properties and comparative clinical outcomes. CI - Copyright (c) 2026, Sanabria et al. FAU - Sanabria, Florencia AU - Sanabria F AD - Neurodevelopment, Instituto HELMAR, Mar del Plata, ARG. LA - eng PT - Journal Article PT - Review DEP - 20261023 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13692760 OTO - NOTNLM OT - #clinical decision-making OT - autism spectrum disorder (asd) OT - clinical assessment tools OT - differential diagnosis OT - functional assessment OT - medical comorbidities OT - neurodevelopmental disorders (nd) OT - pediatric neurodevelopment OT - smart-nb OT - therapeutic goals COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: The author is the creator and developer of SMART-NB, the clinical framework discussed in this manuscript. This relationship is disclosed for transparency. No external funding was received for this work. . EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/10/23 CRDT- 2026/10/24 05:32 PHST- 2026/10/22 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 05:32 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - 10.7759/cureus.118440 [doi] PST - epublish SO - Cureus. 2026 Oct 23;18(10):e118440. doi: 10.7759/cureus.118440. eCollection 2026 Oct. PMID- 42920663 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261025 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - An expert-informed framework of school conditions potentially supporting adolescent physical activity habits: a three-stage consultation in China. PG - 1962254 LID - 10.3389/fpubh.2026.1962254 [doi] LID - 1962254 AB - BACKGROUND: Schools can provide conditions that may support repeated physical activity, but expert endorsement of those conditions does not demonstrate habit formation. This study developed an expert-informed content framework for Chinese adolescents aged 12-18 years. METHODS: A three-stage, Delphi-informed consultation comprised qualitative elicitation and item development, one full quantitative rating stage, and targeted review of proposed final decisions. Of 25 experts approached, 23, 18, and 16 were reported to complete Stages 1, 2, and 3, respectively. The reported analyses used 16 complete cases. Seven earlier-stage contributors withdrew consent; their data are excluded and recorded as no longer retained, preventing full-stage reanalysis. Five theory-informed domains guided the interviews; a predominantly deductive qualitative analysis using a codebook specified before the interviews supported indicator refinement rather than independently establishing their structure. Forty-five literature-derived provisional indicators and five interview-derived additions were consolidated into 34 candidates. Importance, feasibility, and clarity were rated on five-point scales. The importance-based retention rule specified before rating combined a mean >/=4.00, coefficient of variation /=80% ratings of 4 or 5. RESULTS: Thirty-three candidates met the retention rule; SPC9 did not. The retained indicators received uniformly high importance endorsement, but concordance in relative rankings was limited (Kendall's W: importance 0.115, feasibility 0.160, clarity 0.163). Individual-level Stage 3 confirmation distributions were not available in the submitted analytic record, and quantitative convergence across stages was not assessed. The exploratory, sample-relative importance-feasibility matrix assigned 10, 5, 10, and 8 indicators to its four quadrants; 11 of 33 indicators changed quadrant in at least one leave-one-expert-out analysis. CONCLUSION: The resulting curricular, extracurricular, peer, cultural, and institutional indicators specify school conditions that experts considered potentially relevant to habit support. The findings do not establish strong inter-expert consensus, a validated measurement instrument, actual habit formation, or causal effects. Complete-case selection, limited stakeholder representation, and incomplete process records restrict interpretation. More complete source documentation, stakeholder co-design, and prospective measurement and implementation studies are needed. CI - Copyright (c) 2026 Hu, Su, Han, Li, Wang, Liu, Xiong and Li. FAU - Hu, Shaojuan AU - Hu S AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Su, Yi AU - Su Y AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Han, Dong AU - Han D AD - Shenzhen No. 3 Senior High School, Shenzhen, China. FAU - Li, Liting AU - Li L AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Wang, Ran AU - Wang R AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Liu, Yihang AU - Liu Y AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Xiong, Jie AU - Xiong J AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Li, Xinyuan AU - Li X AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. LA - eng PT - Journal Article DEP - 20261009 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Schools MH - Child MH - China MH - *Exercise/psychology MH - Delphi Technique MH - *Habits MH - Female MH - Male MH - *Adolescent Behavior/psychology PMC - PMC13690933 OTO - NOTNLM OT - China OT - adolescent OT - expert consultation OT - habit support OT - modified Delphi approach OT - physical activity OT - school health promotion COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/24 05:35 MHDA- 2026/10/25 03:36 PMCR- 2026/10/09 CRDT- 2026/10/24 04:55 PHST- 2026/08/08 00:00 [received] PHST- 2026/09/13 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/25 03:36 [medline] PHST- 2026/10/24 05:35 [pubmed] PHST- 2026/10/24 04:55 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1962254 [doi] PST - epublish SO - Front Public Health. 2026 Oct 9;14:1962254. doi: 10.3389/fpubh.2026.1962254. eCollection 2026. PMID- 42920505 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261025 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Development and temporal validation of a calibrated machine learning model for in-hospital blood culture positivity using routine clinical data. PG - 1956921 LID - 10.3389/fmed.2026.1956921 [doi] LID - 1956921 AB - BACKGROUND: Among hospitalized patients who have already undergone blood culture collection, routinely available clinical information may support early risk stratification while microbiological results are pending. We developed and temporally validated a calibrated machine learning model for in-hospital blood culture positivity. METHODS: This single-center retrospective study included 44,389 blood culture-related hospitalization records from January 2022 to September 2024. Records from 2022 to 2023 were used for model development and records from 2024 for temporal validation. The primary outcome was at least one laboratory-recorded positive blood culture between index collection and hospital discharge. A Platt-calibrated XGBoost model using demographic characteristics, routine laboratory variables, and missingness indicators was compared with procalcitonin-only and regression-based models. Performance was assessed using discrimination, calibration, threshold-specific metrics, decision curve analysis, and SHAP. RESULTS: The cohort included 3,555 outcome-positive records (8.01%). In temporal validation, the final XGBoost model achieved a ROC-AUC of 0.798 (95% CI, 0.784-0.813), a PR-AUC of 0.266, a Brier score of 0.0619, and a calibration slope of 1.061. At the 5% threshold, sensitivity was 0.877, specificity 0.570, and negative predictive value 0.983. XGBoost showed a modest improvement over logistic regression with missingness indicators, while an exploratory post hoc Age + PCT + BMI logistic comparator achieved a ROC-AUC of 0.757. Performance was stable in the new-patient validation subset but decreased within adult and pediatric subgroups (ROC-AUC 0.679 and 0.663, respectively). Age, procalcitonin, and body mass index were the dominant contributors. CONCLUSION: The calibrated model provided moderate discrimination and favorable calibration for hospitalization-level blood culture positivity risk stratification in the pooled temporal validation cohort. Performance varied across age groups, and much of the predictive information was concentrated in age, PCT, and BMI. The model does not predict the index culture result alone or diagnose clinically adjudicated bloodstream infection. Multicenter external and prospective validation using fixed prediction horizons and adjudicated outcomes is required before clinical implementation. CI - (c) 2026 Huang, Tan, Jiang, Yang, Wang and Huang. FAU - Huang, Tao AU - Huang T AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Tan, Zhenzhen AU - Tan Z AD - School of Pharmacy, Southwest Medical University, Luzhou, China. AD - Department of Pharmacy, The Hejiang People's Hospital, Luzhou, China. FAU - Jiang, Longyang AU - Jiang L AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Yang, Xuping AU - Yang X AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Wang, Shurong AU - Wang S AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Huang, Yilan AU - Huang Y AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. LA - eng PT - Journal Article DEP - 20261009 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13690682 OTO - NOTNLM OT - XGBoost OT - blood culture positivity OT - clinical risk stratification OT - electronic health records OT - machine learning OT - probability calibration OT - temporal validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/24 05:35 MHDA- 2026/10/24 05:36 PMCR- 2026/10/09 CRDT- 2026/10/24 04:44 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/24 05:36 [medline] PHST- 2026/10/24 05:35 [pubmed] PHST- 2026/10/24 04:44 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 10.3389/fmed.2026.1956921 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Oct 9;13:1956921. doi: 10.3389/fmed.2026.1956921. eCollection 2026. PMID- 42920015 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261027 IS - 1863-2491 (Electronic) IS - 1863-2483 (Linking) VI - 20 IP - 1 DP - 2026 Oct 24 TI - Body weight-associated procedural bottlenecks in robot-assisted surgery for congenital biliary dilatation: a step-specific operative time analysis. LID - 1132 [pii] LID - 10.1007/s11701-026-04085-y [doi] AB - Adults and heavier patients undergoing robot-assisted surgery for congenital biliary dilatation may require longer operative times. This study used step-specific video analysis to identify where additional time accumulated and which components remained relatively stable across patient size. Fifty-five patients (32 children and 23 adults) were retrospectively analyzed. Operative videos were divided into seven predefined steps and unclassified time. Step-specific durations were compared between groups. Restricted cubic spline and segmented regression analyses explored relationships between body weight and step-specific operative time. Total operative time was longer in adults than in children (509.0 vs. 386.0 min; P < 0.001). Adults required longer times for access and preparation, the Kocher maneuver, pancreatic-side bile duct dissection, Roux-en-Y limb creation and mesenteric fixation, final procedural steps, and unclassified workflow time. Hepatic duct dissection and ductoplasty and hepaticojejunostomy times were similar between groups. Pancreatic-side dissection time was longer in patients with postoperative pancreatic fistulas than in those without it (83.0 vs. 73.0 min; P = 0.039). Segmented regression yielded an exploratory breakpoint estimate of 17.8 kg (95% confidence interval, 9.6-25.9 kg). Using 18 kg as a data-derived exploratory cutoff, patients weighing >/= 18 kg had longer access, dissection, intestinal preparation, and workflow times, without significant differences in biliary reconstruction times. Longer operative times in adults and heavier patients were concentrated in access, pancreatic-side bile duct dissection, intestinal preparation, and workflow, with no significant difference in biliary reconstruction times. The fistula association and the breakpoint are hypothesis-generating findings that require external validation. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature. FAU - Hayashi, Kaito AU - Hayashi K AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Shirota, Chiyoe AU - Shirota C AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Tainaka, Takahisa AU - Tainaka T AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. tainaka.takahisa.g2@f.mail.nagoya-u.ac.jp. FAU - Makita, Satoshi AU - Makita S AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Okamoto, Masamune AU - Okamoto M AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Yasui, Akihiro AU - Yasui A AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Takimoto, Aitaro AU - Takimoto A AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Takada, Shunya AU - Takada S AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Kato, Daiki AU - Kato D AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Ishii, Hiroki AU - Ishii H AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Asai, Hajime AU - Asai H AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Ota, Kazuki AU - Ota K AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Utsunomiya, Ami AU - Utsunomiya A AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Uchida, Hiroo AU - Uchida H AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. LA - eng GR - JP26vk0124014/Japan Agency for Medical Research and Development/ GR - JP26K03317/Japan Society for the Promotion of Science/ PT - Journal Article DEP - 20261024 PL - England TA - J Robot Surg JT - Journal of robotic surgery JID - 101300401 SB - IM MH - Humans MH - *Operative Time MH - *Robotic Surgical Procedures/methods MH - Retrospective Studies MH - Female MH - Adult MH - Male MH - *Body Weight MH - Child MH - Child, Preschool MH - *Biliary Tract Surgical Procedures/methods MH - Adolescent MH - Infant MH - *Bile Ducts/surgery/abnormalities OTO - NOTNLM OT - Body weight OT - Congenital biliary dilatation OT - Hepaticojejunostomy OT - Operative time OT - Pancreatic fistula OT - Robotic surgery COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics Approval: This study was approved by the Institutional Review Board of Nagoya University Hospital (approval no. 2025-0583). Consent to Participate: The requirement for written informed consent was waived because of the retrospective study design. An opt-out approach was used. Consent to Publish: Not applicable. EDAT- 2026/10/24 05:35 MHDA- 2026/10/24 05:36 CRDT- 2026/10/23 23:20 PHST- 2026/09/08 00:00 [received] PHST- 2026/10/12 00:00 [accepted] PHST- 2026/10/24 05:36 [medline] PHST- 2026/10/24 05:35 [pubmed] PHST- 2026/10/23 23:20 [entrez] AID - 10.1007/s11701-026-04085-y [pii] AID - 10.1007/s11701-026-04085-y [doi] PST - epublish SO - J Robot Surg. 2026 Oct 24;20(1):1132. doi: 10.1007/s11701-026-04085-y. PMID- 42919594 OWN - NLM STAT- In-Process LR - 20261028 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 10 DP - 2026 Oct 23 TI - Lifestyle intervention to improve outcomes in dichorionic twin pregnancies: study protocol for a multicentre randomised controlled trial with an integrated pilot study - the LIFETWIN trial. PG - e122541 LID - 10.1136/bmjopen-2026-122541 [doi] LID - e122541 AB - INTRODUCTION: Preterm birth and small-for-gestational-age (SGA) infants remain major contributors to neonatal morbidity, mortality and healthcare costs. Twin pregnancies account for a disproportionate share of these adverse outcomes, representing 18%-24% of all preterm births in Europe. Despite this high-risk profile, effective preventive strategies for twin pregnancies remain limited and mainly target cervical length. Emerging evidence suggests that maternal lifestyle factors, including diet, physical activity and stress management, may prolong gestational age and improve fetal growth. METHODS AND ANALYSIS: The LIFEstyle intervention to improve TWIN pregnancy (LIFETWIN) - study is a multicentre, open-label, randomised controlled trial. A total of 274 women with dichorionic twin pregnancies will be recruited across 15 sites in Belgium. The full trial will be preceded by an integrated pilot study conducted at four sites to assess feasibility using the RE-AIM framework. Participants will be randomised to standard care or a lifestyle intervention in addition to standard care. The intervention consists of eight midwife-led sessions between gestational weeks 16 and 36, focusing on a Mediterranean-type diet, physical activity, mindfulness and prenatal multivitamin supplementation. Data are collected at baseline, in late pregnancy, at delivery and at 6 weeks postpartum, using clinical records, physical examinations and validated questionnaires. The primary outcome is gestational age at delivery. Secondary outcomes include neonatal birth weight, SGA status, neonatal morbidity and mortality, neonatal intensive care unit admission and length of stay, maternal gestational weight gain, postpartum weight and quality of life. The primary outcome, gestational age at delivery, will be analysed using a linear mixed-effects model, accounting for study-site effects and potential clustering by intervention midwife within the intervention arm. Secondary outcomes will be analysed using models appropriate to the outcome type, including linear mixed models, generalised mixed models and frailty models. ETHICS AND DISSEMINATION: The trial has been approved by the central ethics committee of Leuven (identification number S68251) and by the local ethics committees of each participating site. The trial will be conducted in accordance with the Declaration of Helsinki. All results, whether positive, negative or inconclusive, will be disseminated at national or international scientific meetings and published in peer-reviewed scientific journals. TRIAL REGISTRATION NUMBER: NCT07270640. FAU - Lodewyckx, Katleen AU - Lodewyckx K AUID- ORCID: 0009-0000-6181-1649 AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. FAU - Shafran, Yael Winter AU - Shafran YW AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. FAU - Coucke, Birgit AU - Coucke B AUID- ORCID: 0000-0003-0285-6665 AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Academic Centre for Nursing and Midwifery (AccentVV), Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium. FAU - Put, Martien AU - Put M AUID- ORCID: 0009-0000-5891-636X AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. FAU - Lewi, Liesbeth AU - Lewi L AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. FAU - Bogaerts, Annick AU - Bogaerts A AUID- ORCID: 0000-0003-2718-4682 AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - L-C&Y, KU Leuven Child & Youth Institute, KU Leuven, Leuven, Belgium. AD - University of Plymouth, Faculty of Health, Plymouth, UK. FAU - Smits, Tim AU - Smits T AD - Institute for Media Studies, Katholieke Universiteit Leuven Faculteit Sociale Wetenschappen, Leuven, Belgium. FAU - Noel, Laure AU - Noel L AD - Obstetrics and Gynecology Department, Centre Hospitalier Regional de la Citadelle, Liege, Belgium. FAU - Mesens, Tinne AU - Mesens T AD - Department of Obstetrics and Gynecology, Hospital East-Limburg, Genk, Belgium. FAU - Jani, Jacques AU - Jani J AUID- ORCID: 0000-0003-2252-342X AD - Department of Obstetrics and Gynecology, Brugmann University Hospital, Brussels, Belgium. FAU - Devlieger, Roland AU - Devlieger R AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium roland.devlieger@uzleuven.be. AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. LA - eng PT - Journal Article DEP - 20261023 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM PMC - PMC13711562 OTO - NOTNLM OT - Exercise OT - Life Style OT - Mindfulness OT - NUTRITION & DIETETICS OT - Pregnancy OT - Premature Birth OT - Twin COIS- Competing interests: None declared. EDAT- 2026/10/23 23:32 MHDA- 2026/10/23 23:32 PMCR- 2026/10/23 CRDT- 2026/10/23 21:03 PHST- 2026/10/23 23:32 [medline] PHST- 2026/10/23 23:32 [pubmed] PHST- 2026/10/23 21:03 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - bmjopen-2026-122541 [pii] AID - 10.1136/bmjopen-2026-122541 [doi] PST - epublish SO - BMJ Open. 2026 Oct 23;16(10):e122541. doi: 10.1136/bmjopen-2026-122541. PMID- 42919493 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1557-9840 (Electronic) IS - 0095-5108 (Linking) VI - 53 IP - 4 DP - 2026 Dec TI - Donor Milk: Practical Considerations for Necrotizing Enterocolitis Reduction. PG - 817-827 LID - S0095-5108(26)00085-0 [pii] LID - 10.1016/j.clp.2026.07.011 [doi] AB - The practical considerations for using pasteurized donor human milk (PDHM) require a standardized yet individualized approach. Mother's own milk should be prioritized with PDHM serving as a bridge. Neonatal intensive care unit should focus on early feeding and a base diet of human milk MOM supplemented with PDHM. Human milk is critical to reducing necrotizing enterocolitis risk in very preterm infants. Given variability in PDHM composition, strategic fortification is necessary to optimize growth. Reliable milk handling, staff and family education, and shared decision-making with parents are essential. Collaboration with milk banks and promotion of donation are key to ensuring access and sustainability. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Hair, Amy B AU - Hair AB AD - Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA. Electronic address: abhair@bcm.edu. FAU - Stellwagen, Lisa M AU - Stellwagen LM AD - Department of Pediatrics, University of California, School of Medicine, San Diego, CA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260901 PL - United States TA - Clin Perinatol JT - Clinics in perinatology JID - 7501306 SB - IM MH - Humans MH - *Enterocolitis, Necrotizing/prevention & control MH - *Milk, Human MH - Infant, Newborn MH - *Milk Banks MH - Infant, Premature MH - Pasteurization MH - Infant, Very Low Birth Weight OTO - NOTNLM OT - Mother's own milk OT - Necrotizing enterocolitis OT - Pasteurized donor human milk OT - Preterm formula OT - Preterm infant OT - Very low birth weight infant COIS- Disclosure A.B. Hair: Scientific Advisory Board Member (unpaid) for The NEC Society. L.M. Stellwagen: President of Human Milk Banking Association of North America, Medical Director, University of California Health Milk Bank, Scientific and Advisory Board member, Medela, Americas. EDAT- 2026/10/23 23:32 MHDA- 2026/10/23 23:33 CRDT- 2026/10/23 20:57 PHST- 2026/10/23 23:33 [medline] PHST- 2026/10/23 23:32 [pubmed] PHST- 2026/10/23 20:57 [entrez] AID - S0095-5108(26)00085-0 [pii] AID - 10.1016/j.clp.2026.07.011 [doi] PST - ppublish SO - Clin Perinatol. 2026 Dec;53(4):817-827. doi: 10.1016/j.clp.2026.07.011. Epub 2026 Sep 1. PMID- 42919389 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261025 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Jul 25 TI - Identifying eating behaviour phenotype cut-off scores for childhood obesity: an individual participant data meta-analysis using the Child Eating Behaviour Questionnaire (CEBQ). LID - 10.1186/s12966-026-01951-8 [doi] LID - 98 AB - BACKGROUND: Weight management interventions targeting appetitive traits show promise in treating childhood obesity, yet a tool to identify appetitive phenotypes for personalised treatment is missing. The Child Eating Behaviour Questionnaire (CEBQ) is a widely used measure of eight parent-reported appetitive traits associated with childhood obesity. We aimed to explore the utility of the CEBQ for phenotyping childhood obesity and derive cut-off scores to support clinical decision-making. METHODS: This individual participant data meta-analysis combined cross-sectional data from 17 international studies (N = 15,273) on CEBQ scores and Body Mass Index Standard Deviation Scores from children (2-18 years). The potential of CEBQ subscales (Food Responsiveness, Enjoyment of Food, Emotional Over-eating, Desire to Drink, Satiety Responsiveness, Slowness in Eating, Emotional Under-eating, Food Fussiness) to discriminate weight status was explored in random-effect meta-analyses of Area Under the Curve (AUC) metrics. We explored heterogeneity across studies and age- and sex- specific subgroups. Cut-off scores were derived within subgroups using (a) the Youden's Index and (b) the point maximising specificity after a minimum sensitivity of 60%. We meta-analysed study-specific performance with the selected cut-offs to describe heterogeneity across studies. RESULTS: AUCs for CEBQ subscales ranged from 0.60 to 0.71. The magnitude and shape of associations between CEBQ scores and obesity varied by age and sex. Cut-off performance was generally better in middle- than early childhood. The best performing cut-off score of 2.6 was observed for females aged 7-12 years for Food Responsiveness (Sensitivity: 0.81 [95%CI 0.77, 0.85]; Specificity: 0.85 [95%CI 0.82, 0.88]). High heterogeneity in cut-off performance across studies and wide prediction intervals suggest the need to further investigate external validity. CONCLUSIONS: We provide the first empirically derived CEBQ subscale cut-offs to phenotype children with obesity based on weight-related eating behaviours. Cut-offs could support personalised treatment in clinical and research contexts. FUNDING: MC_UU_00006/6 and MC_UU_00006/5. CI - (c) 2026. The Author(s). FAU - Kudlek, Laura AU - Kudlek L AUID- ORCID: 0000-0003-0947-3640 AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. laura.kudlek@ims.cam.ac.uk. AD - Centre for Preventive Medicine and Digital Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. laura.kudlek@ims.cam.ac.uk. FAU - Smith, Andrea D AU - Smith AD AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. FAU - Ruggiero, Cara F AU - Ruggiero CF AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. FAU - Pennells, Lisa AU - Pennells L AD - Department of Health and Primary Care, University of Cambridge, Cambridge, UK. FAU - Kininmonth, Alice R AU - Kininmonth AR AD - School of Food Science and Nutrition, University of Leeds, Leeds, UK. AD - Leeds Institute for Data Analytics, University of Leeds, Leeds, UK. FAU - Steinsbekk, Silje AU - Steinsbekk S AD - Department of Psychology, Norwegian University of Science and Technology, Hogskoleringen, Norway. FAU - Jansen, Pauline W AU - Jansen PW AD - Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, Netherlands. FAU - Ahern, Amy L AU - Ahern AL AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. FAU - McCarthy, Elaine K AU - McCarthy EK AD - School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. FAU - Gross, Amy AU - Gross A AD - Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. FAU - Viana, Victor AU - Viana V AD - Faculty of Food Sciences and Nutrition, University of Porto, Porto, Portugal. FAU - van Deutekom, Arend W AU - van Deutekom AW AD - Department of Paediatrics, Division of Paediatric Cardiology Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam,, Netherlands. FAU - Spence, John C AU - Spence JC AD - Faculty of Kinesiology, Sport, & Recreation, University of Alberta, Edmonton, AB, Canada. FAU - Fisher, Jennifer Orlet AU - Fisher JO AD - Department of Social and Behavioral Sciences, College of Public Health, Temple University, Philadelphia, PA, USA. FAU - Hayes, Jacqueline AU - Hayes J AD - Alpert Medical School of Brown University and The Miriam Hospital, Providence, RI, USA. FAU - Haycraft, Emma AU - Haycraft E AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - Hardman, Charlotte A AU - Hardman CA AD - Department of Psychology, University of Liverpool, Liverpool, UK. FAU - Silveira, Patricia P AU - Silveira PP AD - Department of Psychiatry, McGill University, Montreal, Quebec, Canada. FAU - Emond, Jennifer A AU - Emond JA AD - Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Lebanon, NH, USA. FAU - Eloranta, Aino-Maija AU - Eloranta AM AD - Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland. FAU - Dos Passos Gomes, Darlise R AU - Dos Passos Gomes DR AD - Department of Nutrition, Federal University of Pelotas, Pelotas, RS, Brazil. FAU - Lumeng, Julie C AU - Lumeng JC AD - Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA. FAU - Cross, Matthew B AU - Cross MB AD - USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Bates, Houston, TX, 1100, USA. FAU - Carnell, Susan AU - Carnell S AD - Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. FAU - Fildes, Alison AU - Fildes A AD - School of Psychology, University of Leeds, Leeds, UK. FAU - Llewellyn, Clare AU - Llewellyn C AD - Department of Behavioural Science and Health, University College London, London, UK. LA - eng GR - MC_UU_00006/6/MRC_/Medical Research Council/United Kingdom GR - MC_UU_00006/5/MRC_/Medical Research Council/United Kingdom GR - NIHR203312/National Institute for Health and Care Research/ GR - NIHR203312/National Institute for Health and Care Research/ GR - RG/F/23/110103/BHF_/British Heart Foundation/United Kingdom GR - PR:1948633/Economic and Social Research Council/ PT - Journal Article PT - Meta-Analysis DEP - 20260725 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Child MH - *Feeding Behavior/psychology MH - Phenotype MH - Surveys and Questionnaires MH - Female MH - Child, Preschool MH - Body Mass Index MH - *Pediatric Obesity/psychology/diagnosis MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - *Child Behavior PMC - PMC13693115 OTO - NOTNLM OT - Behavioural obesity phenotypes OT - Child eating behaviour questionnaire (CEBQ) OT - Childhood obesity OT - Cut-off scores COIS- Declarations. Ethics approval and consent to participate: Ethical approval and consent to participate were obtained by original investigators for each included study. No additional ethical approval was obtained for this secondary analysis of original study data. Consent for publication: Not applicable. Competing interests: ALA is a member of the scientific advisory board for Weight Watchers and has undertaken consultancy for Menwell Health and Juniper (all payments to her institution). CAH reports research funding for work unrelated to the submitted manuscript from the American Beverage Association; membership of Global Nutrition Advisory Council for Mars; primary supervisor of PhD studentship funded by Coca-Cola; membership of UK Government's Food Standards Agency's Advisory Committee on Social Sciences; honoraria from International Sweeteners Association and International Food Information Council for invited talks. CL held funding from the UKRI Medical Research Council Grant to support an intervention based on child eating behaviour, involving eating behaviour phenotyping. All other authors have no competing interests to declare. EDAT- 2026/10/23 23:32 MHDA- 2026/10/24 05:35 PMCR- 2026/07/25 CRDT- 2026/10/23 20:52 PHST- 2026/01/09 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/10/24 05:35 [medline] PHST- 2026/10/23 23:32 [pubmed] PHST- 2026/10/23 20:52 [entrez] PHST- 2026/07/25 00:00 [pmc-release] AID - 10.1186/s12966-026-01951-8 [pii] AID - 1951 [pii] AID - 10.1186/s12966-026-01951-8 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Jul 25;23(1):98. doi: 10.1186/s12966-026-01951-8. PMID- 42919282 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 1478-7954 (Electronic) IS - 1478-7954 (Linking) VI - 24 IP - 1 DP - 2026 Jul 28 TI - Neonatal admissions and mortality: a statistical adjustment approach using birthweight-specific curves to address bias due to underreporting in 65 hospitals in four African countries. LID - 10.1186/s12963-026-00496-z [doi] LID - 62 AB - BACKGROUND: Underreporting of neonatal admissions and deaths - particularly among < 1000 g newborns - compromises the plausibility of in-patient neonatal mortality rate (iNMR) estimates. This limits progress tracking, since 2.3 million neonatal deaths occur annually, and 65 countries are projected to miss the Sustainable Development Goal (SDG) 3.2 target of fewer than 12 deaths per 1000 live births by 2030. Reliable iNMR estimates are essential for national and hospital-level monitoring. This study assessed birthweight-specific adjustment curves developed using simulated data, and extended the approach to routine data from 172,809 neonatal admissions across four African countries in the NEST360 network. METHODS: Simulated data were generated using birthweight intervals of 500 g from 500 to 5000 g, with 1000 values per category representing 1000 hospitals. Admissions were drawn from a negative binomial distribution and mortality rates from a beta distribution based on published birthweight-specific iNMRs. Adjustment functions were developed using data from 500 hospitals without underreporting and tested on 500 with induced underreporting. This approach was then extended to real data from 65 NEST360 partnering hospitals. The adjustment functions were derived from 26 hospitals with plausible reporting (iNMR >/= 700 per 1000 for neonates < 1000 g). RESULTS: In simulated data, adjusted iNMRs closely matched original values, with median differences ranging from - 4 to 9 deaths per 1000 across birthweight categories. In NEST360 dataset, unadjusted iNMRs were 121 (range 13-272) in Nigeria, 128 (60-214) in Tanzania, 132 (42-234) in Malawi, and 135 (60-250) in Kenya per 1000 admissions. After adjustment, estimates increased to 162 (127-333), 183 (128-233), 174 (120-268), and 172 (123-261), respectively. Variability across hospitals decreased, with standard deviation reducing from 13 to 5 deaths per 1000. CONCLUSIONS: Birthweight specific adjustment functions provide a practical and scalable approach to improving the plausibility of iNMR estimates where underreporting is common. These methods can be integrated into routine systems (such as Electronic Medical Record Systems and DHIS2) where key data are available, with modest computational demands. Their use can strengthen mortality surveillance and support more reliable policy and planning, while contributing to progress toward SDG 3.2, contingent on continued improvements in data quality and system capacity. CI - (c) 2026. The Author(s). FAU - Malla, Lucas AU - Malla L AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. lucas.malla@lshtm.ac.uk. FAU - Wong, Siu Nam AU - Wong SN AD - The University of Hong Kong, Pokfulam Road & Bonham Road, Pok Fu Lam, Central and Western District, Hong Kong SAR, China. FAU - Ngwala, Samuel AU - Ngwala S AD - Research Support Center, School of Public Health and Family Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi. FAU - Zimba, Evelyn AU - Zimba E AD - Research Support Center, School of Public Health and Family Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi. FAU - Chiume, Msandeni AU - Chiume M AD - Research Support Center, School of Public Health and Family Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi. FAU - Lufesi, Norman AU - Lufesi N AD - Research Support Center, School of Public Health and Family Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi. FAU - Kawaza, Kondwani AU - Kawaza K AD - Research Support Center, School of Public Health and Family Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi. FAU - Masanja, Honorati AU - Masanja H AD - Health Systems Impact Evaluation and Policy Department, Ifakara Health Institute, Dar Es Salaam, Tanzania. FAU - Shabani, Josephine AU - Shabani J AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. AD - Health Systems Impact Evaluation and Policy Department, Ifakara Health Institute, Dar Es Salaam, Tanzania. FAU - Mshana, Prosper AU - Mshana P AD - Health Systems Impact Evaluation and Policy Department, Ifakara Health Institute, Dar Es Salaam, Tanzania. FAU - Tillya, Robert AU - Tillya R AD - Health Systems Impact Evaluation and Policy Department, Ifakara Health Institute, Dar Es Salaam, Tanzania. FAU - Salim, Nahya AU - Salim N AD - Health Systems Impact Evaluation and Policy Department, Ifakara Health Institute, Dar Es Salaam, Tanzania. AD - Muhimbili University of Health and Allied Science (MUHAS), Dar es Salaam, United Republic of Tanzania. FAU - Wainaina, John AU - Wainaina J AD - Rice360 Institute for Global Health Technologies, Rice University, Texas, USA. FAU - Thomas, Julius AU - Thomas J AD - Rice360 Institute for Global Health Technologies, Rice University, Texas, USA. FAU - Chen, Junwei AU - Chen J AD - Rice360 Institute for Global Health Technologies, Rice University, Texas, USA. FAU - Okech, Franklin AU - Okech F AD - Kenya Medical Research Institute-Wellcome Trust, Nairobi, Kenya. FAU - Okello, George AU - Okello G AD - Rice360 Institute for Global Health Technologies, Rice University, Texas, USA. FAU - Macharia, William AU - Macharia W AD - Aga Khan University, Nairobi, Kenya. FAU - Dosunmu, Olabisi AU - Dosunmu O AD - APIN Public Health Initiatives, Nairobi, Nigeria. FAU - Ezeaka, Chinyere AU - Ezeaka C AD - Rice360 Institute for Global Health Technologies, Rice University, Texas, USA. FAU - Odedere, Opeyemi AU - Odedere O AD - Rice360 Institute for Global Health Technologies, Rice University, Texas, USA. FAU - Ogero, Morris AU - Ogero M AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. FAU - Cross, James H AU - Cross JH AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. FAU - Penzias, Rebecca E AU - Penzias RE AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. FAU - Bohne, Christine AU - Bohne C AD - Rice360 Institute for Global Health Technologies, Rice University, Texas, USA. FAU - Richards-Kortum, Rebecca AU - Richards-Kortum R AD - Rice360 Institute for Global Health Technologies, Rice University, Texas, USA. FAU - Oden, Maria AU - Oden M AD - Rice360 Institute for Global Health Technologies, Rice University, Texas, USA. FAU - Ohuma, Eric O AU - Ohuma EO AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. FAU - Lawn, Joy E AU - Lawn JE AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. CN - with NEST360 Collaborative authorship group LA - eng PT - Journal Article DEP - 20260728 PL - England TA - Popul Health Metr JT - Population health metrics JID - 101178411 SB - IM MH - Humans MH - *Infant Mortality/trends MH - *Birth Weight MH - Infant, Newborn MH - Female MH - Bias MH - Infant MH - Malawi/epidemiology MH - Nigeria/epidemiology MH - Tanzania/epidemiology MH - Hospital Mortality MH - Africa/epidemiology MH - Hospitals MH - Kenya/epidemiology MH - *Patient Admission/statistics & numerical data MH - Male PMC - PMC13693040 OTO - NOTNLM OT - Bayesian OT - Birthweight OT - Data quality OT - Health information systems OT - Neonatal mortality OT - Underreporting COIS- Declarations. Ethics and consent to participate: The complex evaluation of NEST360 was granted ethical approval from the Institutional Review Boards of all four countries, the London School of Hygiene & Tropical Medicine and Rice University. Consent for publication: "Not applicable". Competing interests: The authors declare no competing interests. EDAT- 2026/10/23 23:32 MHDA- 2026/10/23 23:33 PMCR- 2026/07/28 CRDT- 2026/10/23 20:47 PHST- 2025/08/07 00:00 [received] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/10/23 23:33 [medline] PHST- 2026/10/23 23:32 [pubmed] PHST- 2026/10/23 20:47 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 10.1186/s12963-026-00496-z [pii] AID - 496 [pii] AID - 10.1186/s12963-026-00496-z [doi] PST - epublish SO - Popul Health Metr. 2026 Jul 28;24(1):62. doi: 10.1186/s12963-026-00496-z. PMID- 42918828 OWN - NLM STAT- Publisher LR - 20261023 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Oct 22 TI - Collaborative role of muscle ultrasonography and subjective global-nutritional assessment in pediatric end-stage renal disease. LID - 10.1038/s41390-026-05525-z [doi] AB - BACKGROUND: Nutritional well-being in childhood chronic kidney disease (CKD) represents a multidisciplinary problem. Nevertheless, reliable nutritional status assessment considering underlying pathogenesis remains challenging. So, we aimed to assess the collaborative role of quadriceps muscle ultrasonography and subjective global nutritional assessment (SGNA) in evaluating childhood end-stage renal disease on hemodialysis (ESRD-HD). METHODS: Sixty-eight children with ESRD-HD were enrolled in addition to 68 age- and sex-matched healthy controls. All participants underwent nutritional screening through SGNA, 24-h dietary recall estimation, anthropometric measurements, evaluation of protein energy wasting (PEW), and quadriceps muscle ultrasonography. RESULTS: SGNA identified malnourishment in 85.3% of ESRD-HD children, while reduced/low muscle mass (LMM) by ultrasound was estimated in 73.6%, compared to PEW documentation in 70.6% of them. Total caloric intake discriminates LMM at a cutoff level of /=70% of exercises), and few negative effects were reported, while usability was moderate. Qualitative feedback highlighted structured daily routines and skill acquisition as facilitators, with repetitive self-monitoring and minor interface challenges as barriers. BodyScreen is a feasible, safe, and promising early intervention for young women at elevated ED risk, particularly those with appearance-motivated social media use. Future trials should include a control group, recruit more diverse samples, evaluate longer-term outcomes, and incorporate qualitative feedback to enhance usability and engagement. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Mason, Louise AU - Mason L AD - Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. FAU - Yarmey, Victoria AU - Yarmey V AD - Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. FAU - Li, Shuya AU - Li S AD - Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. FAU - Muzamil, Mohamed AU - Muzamil M AD - Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. FAU - Kumar, Sumit AU - Kumar S AD - Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. FAU - Linardon, Jake AU - Linardon J AD - School of Psychology, Faculty of Health, Deakin University, Burwood, VIC, Australia. FAU - Sherry, Simon B AU - Sherry SB AD - Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada. FAU - Lacroix, Emilie AU - Lacroix E AD - Department of Psychology, University of New Brunswick, Fredericton, NB, Canada. FAU - Mills, Jennifer S AU - Mills JS AD - Department of Psychology, Faculty of Health, York University, Toronto, Canada. FAU - Keshen, Aaron AU - Keshen A AD - Department of Psychiatry, Dalhousie University & Nova Scotia Health, Halifax, NS, Canada. FAU - Meier, Sandra M AU - Meier SM AD - Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; IWK Health Centre, Halifax, NS, Canada. Electronic address: sandra.meier@iwk.nshealth.ca. LA - eng PT - Journal Article DEP - 20261023 PL - Netherlands TA - Body Image JT - Body image JID - 101222431 SB - IM OTO - NOTNLM OT - Body dissatisfaction OT - Eating disorders OT - Ecological momentary intervention OT - Mobile health OT - Perfectionism OT - Social Media COIS- Declaration of Competing Interest Jake Linardon is an Associate Editor of Body Image and author of this article. He was excluded from editorial decision-making related to the handling of this article for publication in the journal. EDAT- 2026/10/23 23:31 MHDA- 2026/10/23 23:31 CRDT- 2026/10/23 18:20 PHST- 2026/05/19 00:00 [received] PHST- 2026/10/09 00:00 [revised] PHST- 2026/10/12 00:00 [accepted] PHST- 2026/10/23 23:31 [medline] PHST- 2026/10/23 23:31 [pubmed] PHST- 2026/10/23 18:20 [entrez] AID - S1740-1445(26)00185-3 [pii] AID - 10.1016/j.bodyim.2026.102211 [doi] PST - aheadofprint SO - Body Image. 2026 Oct 23;59:102211. doi: 10.1016/j.bodyim.2026.102211. PMID- 42913715 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 17 IP - 5 DP - 2026 Oct TI - Machine Learning Integrating Quantitative MRI and Clinical Features Predicts Loss of Ambulation in Duchenne Muscular Dystrophy. LID - e70413 [pii] LID - 10.1002/jcsm.70413 [doi] AB - BACKGROUND: Loss of ambulation (LOA) is a key milestone in Duchenne muscular dystrophy (DMD) with highly variable timing, complicating clinical counselling and trial design. Quantitative MRI non-invasively assesses muscle fat infiltration, yet few models have integrated MRI with clinical variables for individualized LOA prediction. We aimed to develop and validate a machine-learning model integrating quantitative MRI and clinical features to predict time to LOA and to derive interpretable, individualized risk estimates and candidate thresholds. METHODS: This prospective study enrolled 188 boys with DMD (median age 9.10 years). Quantitative MRI parameters (T1, T2, fat fraction [FF]) of 19 hip/thigh muscles and clinical variables were measured. Patients were randomly split into training (80%) and test (20%) sets. Feature selection used LASSO, Boruta and recursive feature elimination based on random survival forest (RSF). Three survival models were compared: RSF and a ridge-penalised Cox model (both integrating clinical and MRI-derived features) and a multivariable Cox model restricted to clinical variables. Performance was assessed by concordance index (C-index), time-dependent area under the curve (AUC), integrated Brier score (IBS) and decision curve analysis at 12, 24, 36 and 48 months. RESULTS: Over median 43.5 months follow-up, 66 patients (35.1%) experienced LOA. Six predictors were retained: NSAA score, MRC%, age and three FF parameters (rectus femoris, vastus lateralis, obturator internus). In the test set (n = 40, 15 events), RSF achieved a C-index of 0.870 (95% CI, 0.764-0.957), outperforming the clinical Cox (0.804) and ridge Cox (0.853) model. Time-dependent AUCs of the RSF model were 0.984, 0.971, 0.913 and 0.850 at 12, 24, 36 and 48 months. RSF showed the best calibration, with the lowest IBS (0.076, 95% CI: 0.052-0.111), followed closely by the ridge Cox model (0.078) and the clinical Cox model (0.109). RSF stratified patients into low-risk, intermediate-risk and high-risk groups; no LOA events occurred in the low-risk group, with annual event rates were 7.2% and 34.6% in the intermediate- and high-risk groups (log-rank p = 0.0025). SHAP analysis identified exploratory thresholds (NSAA < 14.55, MRC% < 68.36%, rectus femoris FF > 32.30%, vastus lateralis FF > 58.00%, obturator internus FF > 7.43%). An interactive web application enables individualized risk prediction (https://westcndmd-timer-loa-risk-prediction-tool-8cygtrrbykvd9snmfcnhrp.streamlit.app/). CONCLUSIONS: A machine-learning-based RSF model integrating quantitative MRI FF metrics and clinical variables exhibited favourable predictive performance for time to LOA in DMD across short- and long-term horizons. It provided interpretable, individualized risk estimates and was deployed as an online tool to support clinical decision-making and trial enrichment. CI - (c) 2026 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Liu, Chuan AU - Liu C AUID- ORCID: 0000-0002-8126-7684 AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Song, Yu AU - Song Y AUID- ORCID: 0000-0002-1198-0732 AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wan, Jiayu AU - Wan J AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Xu, Ting AU - Xu T AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Zhang, Xinyuan AU - Zhang X AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Yan, Yiqiao AU - Yan Y AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Fu, Hang AU - Fu H AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Cai, Xiaotang AU - Cai X AUID- ORCID: 0000-0001-8940-8253 AD - Department of Rehabilitation and Department of Pediatric Neurology, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Guo, Yingkun AU - Guo Y AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wang, Yun AU - Wang Y AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Xu, Huayan AU - Xu H AUID- ORCID: 0000-0003-0801-0695 AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. LA - eng GR - HF-CSC2019B01/Clinical Research Funding of Chinese Society of Cardiovascular Disease (CSC)/ GR - 2022-GH03-00011-HZ/Project of Chengdu Science and Technology/ GR - 82572196/National Natural Science Foundation of China/ GR - 82471970/National Natural Science Foundation of China/ GR - 824B2052/National Natural Science Foundation of China/ GR - 82402250/National Natural Science Foundation of China/ GR - 825B2052/National Natural Science Foundation of China/ GR - 2026NSFSCZY0011/Key Project of Natural Science Foundation of Sichuan Province/ GR - 2026NSFSC0584/Natural Science Foundation of Sichuan Province/ GR - 2026-YF08-00166-GX/Chengdu Science and Technology Program/ GR - 2026-XT00-00013-GX/Chengdu Science and Technology Program/ PT - Journal Article PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Humans MH - *Muscular Dystrophy, Duchenne/diagnostic imaging/physiopathology/diagnosis MH - *Magnetic Resonance Imaging/methods MH - *Machine Learning MH - Male MH - Child MH - Prospective Studies MH - *Walking MH - Random Forest MH - Predictive Learning Models MH - Prognosis PMC - PMC13690469 OTO - NOTNLM OT - Duchenne muscular dystrophy OT - fat fraction OT - loss of ambulation OT - machine learning OT - quantitative MRI OT - random survival forest COIS- The authors declare no conflicts of interest. EDAT- 2026/10/23 23:31 MHDA- 2026/10/23 23:32 PMCR- 2026/10/22 CRDT- 2026/10/23 17:59 PHST- 2026/09/07 00:00 [revised] PHST- 2026/06/25 00:00 [received] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/23 23:32 [medline] PHST- 2026/10/23 23:31 [pubmed] PHST- 2026/10/23 17:59 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - e70413 [pii] AID - JCSM70413 [pii] AID - 10.1002/jcsm.70413 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2026 Oct;17(5):e70413. doi: 10.1002/jcsm.70413. PMID- 42912754 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Determine and compare limb specific predictors based on the foot pressure index of right and left foot among young adults in Saudi Arabia using machine learning models. PG - e0360520 LID - 10.1371/journal.pone.0360520 [doi] LID - e0360520 AB - Foot posture is a key determinant of limb-biomechanics, gait balance as well as functional mobility. Usage of foot pressure index (FPI) is widespread to but the determinants of FPI without accounting to the left right foot differences. Therefore, identifying limb-specific determinants would enhance screening accuracy and help in more targeted interventions. The objective of the study was to determine and compare limb specific predictors based on the foot pressure index of right and left foot among young adults using machine learning models. A total of 581 (290 females and 291 males) 18-25-year-old young adults were assessed on anthropometric measures, joint hyper mobility and functional mobility. Using SAS-Viya, separate entropy-based decision trees, along with logistic regression models were developed and model performance was evaluated using validation-test accuracy and area under the curve (AUC). Decision tree models outperformed logistic regression for both FPI-Left (FPI-L) and FPI-Right (FPIR). FPIR was primarily predicted by joint hyper mobility, followed by stair ascent time, stability as well as BMI with stronger influence of both structural and load related factors. FPIL was predicted by closed-eye balance along BMI, open eye balance, stair ascent, Beighton score, underscoring the role of sensory motor control. The findings of the study reflect that young adults foot posture is complex, limb specific interactions among anthropometric, functional and sensory factors. CI - Copyright: (c) 2026 Samuel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Samuel, Paul Silvian AU - Samuel PS AUID- ORCID: 0000-0002-4920-6347 AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Thomas, Resmi Ann AU - Thomas RA AD - College of Business, Centennial College, Toronto, Canada. FAU - Kakaraparthi, Venkata Nagaraj AU - Kakaraparthi VN AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Reddy, Ravi Shankar AU - Reddy RS AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Alshahrani, Mastour Saeed AU - Alshahrani MS AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Alnakhli, Hani H AU - Alnakhli HH AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Alkhamis, Batool Abdulelah AU - Alkhamis BA AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Gular, Kumar AU - Gular K AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. LA - eng PT - Comparative Study PT - Journal Article DEP - 20261023 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Machine Learning MH - *Foot/physiology MH - Pressure MH - Young Adult MH - Saudi Arabia MH - Male MH - Adolescent MH - Adult MH - Gait/physiology MH - Biomechanical Phenomena MH - Predictive Learning Models PMC - PMC13693902 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 PMCR- 2026/10/23 CRDT- 2026/10/23 13:45 PHST- 2026/04/17 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 13:45 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - PONE-D-26-17999 [pii] AID - 10.1371/journal.pone.0360520 [doi] PST - epublish SO - PLoS One. 2026 Oct 23;21(10):e0360520. doi: 10.1371/journal.pone.0360520. eCollection 2026. PMID- 42912465 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261028 IS - 1949-0984 (Electronic) IS - 1949-0976 (Print) IS - 1949-0976 (Linking) VI - 18 IP - 1 DP - 2026 Dec 31 TI - AhR ligands in necrotizing enterocolitis: a provisional evidence map of ligand-specific biology and translational considerations. PG - 2743958 LID - 10.1080/19490976.2026.2743958 [doi] LID - 2743958 AB - Necrotizing enterocolitis (NEC) remains a major cause of gastrointestinal morbidity and mortality in preterm infants, with no targeted mechanism-based therapy. Aryl hydrocarbon receptor (AhR) signaling is an emerging host-microbe interface because it integrates dietary, microbial, milk-derived, and host-derived ligands that regulate intestinal inflammation, epithelial homeostasis, and barrier integrity. Direct NEC-specific evidence for individual AhR ligands, however, remains sparse and uneven. This focused review maps direct NEC intervention evidence, independent replication, human NEC association or ex vivo evidence, AhR dependency, compartment specificity, mechanistic resolution, and translational considerations. Indole-3-carbinol (I3C), the synthetic agonist A18, and 3-indoleacrylic acid (IA) have direct intervention evidence in experimental NEC models. Two independent NEC studies support I3C, although the implicated cellular compartment differs between models. A18 provides direct protection in an experimental NEC model, activates AhR, and exhibits anti-inflammatory effects in human intestinal explants. However, it has not been independently replicated. IA is currently the most comprehensively characterized microbiota-derived ligand in NEC models. However, its mechanistic evidence predominantly comes from one recent study and awaits independent replication. Indole-3-lactic acid, indole-3-acetic acid, and indole-3-sulfate remain physiologically relevant candidates, supported by immature intestinal, human milk, or neonatal metabolic studies. Overall, current evidence supports a ligand-specific view of AhR biology in NEC while highlighting major gaps in replication, human validation, and translational studies. FAU - Ferraris, Laurent AU - Ferraris L AUID- ORCID: 0000-0002-9541-4825 AD - Universite Paris Cite, Inserm, FPRM, Faculte de Pharmacie de Paris, Paris, France. AD - FHU Prem'IMPACT Perinatal inflammation and prematurity, Paris, France. FAU - Ferecatu, Ioana AU - Ferecatu I AUID- ORCID: 0000-0001-6842-9506 AD - Universite Paris Cite, Inserm, FPRM, Faculte de Pharmacie de Paris, Paris, France. AD - FHU Prem'IMPACT Perinatal inflammation and prematurity, Paris, France. FAU - Aires, Julio AU - Aires J AD - Universite Paris Cite, Inserm, FPRM, Faculte de Pharmacie de Paris, Paris, France. AD - FHU Prem'IMPACT Perinatal inflammation and prematurity, Paris, France. LA - eng PT - Journal Article PT - Review DEP - 20261023 PL - United States TA - Gut Microbes JT - Gut microbes JID - 101495343 RN - 0 (Receptors, Aryl Hydrocarbon) RN - 0 (Ligands) RN - 0 (Indoles) RN - C11E72455F (indole-3-carbinol) RN - 0 (Basic Helix-Loop-Helix Proteins) SB - IM MH - Humans MH - *Receptors, Aryl Hydrocarbon/metabolism/agonists/genetics MH - *Enterocolitis, Necrotizing/metabolism/drug therapy/microbiology MH - Ligands MH - Indoles/pharmacology/metabolism MH - Animals MH - Infant, Newborn MH - Infant, Premature MH - Signal Transduction MH - Gastrointestinal Microbiome MH - *Basic Helix-Loop-Helix Proteins/metabolism/agonists PMC - PMC13699851 OTO - NOTNLM OT - 3-indoleacrylic acid OT - Necrotizing enterocolitis OT - aryl hydrocarbon receptor OT - epithelial necroptosis OT - indole-3-carbinol OT - microbiota OT - prematurity OT - tryptophan metabolites COIS- No potential conflicts of interest were disclosed. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 PMCR- 2026/10/23 CRDT- 2026/10/23 13:33 PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 13:33 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - 2743958 [pii] AID - 10.1080/19490976.2026.2743958 [doi] PST - ppublish SO - Gut Microbes. 2026 Dec 31;18(1):2743958. doi: 10.1080/19490976.2026.2743958. Epub 2026 Oct 23. PMID- 42912045 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261024 IS - 1678-8060 (Electronic) IS - 0074-0276 (Print) IS - 0074-0276 (Linking) VI - 121 DP - 2026 TI - Application of image analysis in the evaluation of blood feeding by Lutzomyia longipalpis using an artificial feeding system with synthetic membranes. PG - e260065 LID - S0074-02762026000105053 [pii] LID - 10.1590/0074-02760260065 [doi] LID - e260065 AB - BACKGROUND: Blood feeding is essential for the maintenance of laboratory colonies and for experimental studies involving sand fly-parasite interactions. However, artificial feeding systems for Lutzomyia longipalpis, the principal vector of Leishmania infantum, the etiological agent of visceral leishmaniasis in the Americas, remain limited by low engorgement rates and methodological constraints in blood meal quantification. OBJECTIVES: This study evaluated the feeding performance of Lu. longipalpis on different membranes in an artificial feeder and applied an image-based approach to quantify blood meal size. METHODS: Females were fed either on anaesthetised hamsters (in vivo control) or using a Hemotek(R) artificial feeder equipped with chick skin (CHK), hydrated collagen membrane treated with plasma gel (COL+PG), or untreated hydrated collagen membrane (COL). Blood meal size was estimated through digital image analysis in Fiji/ImageJ using two regions of interest: whole abdomen area (AbdA) and red-coloured blood area (BldA). FINDINGS: Feeding rates were highest on live hosts (88.75%), followed by CHK (72.34%) and COL+PG (72.08%), whereas COL yielded significantly lower engorgement (54.67%). Although abdominal area was greater in females fed on hamsters, no significant differences in red-coloured area were detected among artificial membrane treatments. A strong positive correlation was observed between AbdA and BldA measurements (R(2) = 0.85), validating the image-based method. The use of plasma-treated collagen membranes achieved feeding rates comparable to CHK and was fully compatible with semi-automated image analysis. MAIN CONCLUSIONS: These findings demonstrate that hydrated collagen membranes treated with plasma gel constitute a viable and ethically preferable alternative to bird-derived membranes for the artificial feeding of Lu. longipalpis, while image analysis provides a precise, reproducible, and practical method for blood meal quantification. Collectively, this approach refines laboratory experiments Lu. longipalpis and enhances methodological reliability in studies of sand fly biology and vector-parasite interactions. FAU - Costa, Lidiane Medeiros da AU - Costa LMD AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Sant'Anna, Mauricio Roberto Viana AU - Sant'Anna MRV AUID- ORCID: 0000-0002-2504-0979 AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Vaz, Laura Aquino AU - Vaz LA AD - Pontificia Universidade Catolica de Minas Gerais, Belo Horizonte, MG, Brasil. FAU - Cruz, Geisler Peixoto da AU - Cruz GPD AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Lara, Luisa de Melo AU - Lara LM AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Paula, Gabriel Davi Medeiros de AU - Paula GDM AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Araujo, Ricardo Nascimento AU - Araujo RN AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Artropodes Hematofagos, Belo Horizonte, MG, Brasil. FAU - Gontijo, Nelder de Figueiredo AU - Gontijo NF AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Pereira, Marcos Horacio AU - Pereira MH AUID- ORCID: 0000-0003-4843-0088 AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. LA - eng PT - Journal Article DEP - 20261016 PL - Brazil TA - Mem Inst Oswaldo Cruz JT - Memorias do Instituto Oswaldo Cruz JID - 7502619 RN - 0 (Membranes, Artificial) RN - 9007-34-5 (Collagen) SB - IM MH - Animals MH - Female MH - *Psychodidae/physiology MH - *Feeding Behavior/physiology MH - *Membranes, Artificial MH - *Insect Vectors/physiology MH - *Image Processing, Computer-Assisted/methods MH - Cricetinae MH - Collagen PMC - PMC13673989 COIS- The authors declare that they have no conflict of interest. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 PMCR- 2026/10/16 CRDT- 2026/10/23 13:24 PHST- 2026/02/26 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 13:24 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - S0074-02762026000105053 [pii] AID - 10.1590/0074-02760260065 [doi] PST - epublish SO - Mem Inst Oswaldo Cruz. 2026 Oct 16;121:e260065. doi: 10.1590/0074-02760260065. eCollection 2026. PMID- 42911592 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261026 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 10 DP - 2026 Oct 1 TI - Emotion-Focused Behavioral Weight Loss Treatment for Adolescents: A Randomized Clinical Trial. PG - e2639867 LID - 10.1001/jamanetworkopen.2026.39867 [doi] LID - e2639867 AB - IMPORTANCE: Family-based behavioral treatment (FBT) efficacy decreases in adolescence, a developmental period of gradual maturation and increasing autonomy during which emotion regulation skills develop. OBJECTIVE: To evaluate the feasibility and efficacy of FBT alone compared with FBT plus emotion regulation across 6 months of treatment and 12 months of follow-up on adolescent weight change, emotion regulation, emotional eating, and parent weight change. DESIGN, SETTING, AND PARTICIPANTS: This parallel-group randomized clinical trial of adolescents 13 to 16 years of age with body mass index (BMI) in the 85th percentile or higher but less than the 99.9th percentile was conducted from August 29, 2019, to January 4, 2024, at 2 university clinics. Central randomization was completed by a statistician, and outcome assessors were blinded to treatment condition. The majority of treatments and assessments were delivered remotely via video conference due to the COVID-19 pandemic. INTERVENTIONS: FBT plus emotion regulation vs traditional FBT skills alone for weight loss. FBT included nutrition and physical activity education, behavior change strategies, and parenting skills. Both treatments had 6 months of adolescent and parent groups and behavior coaching sessions. The combined group included FBT skills and added dialectical behavior therapy and emotion-focused therapy. MAIN OUTCOMES AND MEASURES: The main outcomes were adolescent weight (body mass index [BMI] z score (BMIz) and BMI as a percentage of the 95th BMI percentile [%BMIp95]), emotion regulation skills (measured by Difficulties in Emotion Regulation Scale [DERS] scores), emotional eating behaviors (measured by Emotional Eating Scale [EES] scores), parent weight, and feasibility and acceptability of treatment. Primary outcome analyses used an intention-to-treat approach. RESULTS: A total of 166 (FBT plus emotion regulation = 84; FBT = 82) dyads (adolescents: mean [SD] age, 14.3 [1.2] years; 95 [57%] female; mean [SD] BMIz, 2.2 [0.6]; mean [SD] %BMIp95, 120.4 [21.4]; parents: mean [SD] age, 45.3 [6.5] years; 141 [85%] female; mean [SD] BMI, 32.6 [7.0]) were assessed at baseline, midtreatment, posttreatment, and 6- and 12-month follow-up visits. There were no statistically significant differences in posttreatment weight loss among adolescents receiving FBT plus emotion regulation compared with FBT (difference in BMIz, 0.03 [95% CI, -0.05 to 0.10]). However, adolescents in FBT plus emotion regulation did not regain as much weight at the 12-month follow-up (difference in BMIz, -0.09 [95% CI, -0.17 to -0.02]). At the 12-month follow-up, 4% (95% CI, 1%-12%) of adolescents in FBT and 22% (95% CI, 8%-48%) of adolescents in FBT plus emotion regulation lost a clinically significant amount of weight (>/=0.20 BMIz). At 12 months' follow-up, parent weight (difference in BMI, 0.51 [95% CI, -0.03 to 1.05]) and adolescent emotion regulation (difference in DERS scores, -0.06 [95% CI, -0.25 to 0.50]) did not differ by treatment. By contrast, the FBT plus emotion regulation group had lower scores than the FBT group on emotional eating (difference in EES scores, -0.39 [95% CI, -0.63 to -0.15]). CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of 166 parent-adolescent dyads, adding emotion regulation skills to FBT did not improve weight loss during treatment but was associated with less weight regain and lower emotional eating through the 12-month follow-up. These findings suggest that adding emotion regulation skills to an FBT program may attenuate weight regain and decrease emotional eating among adolescents. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03674944. FAU - Boutelle, Kerri N AU - Boutelle KN AD - Department of Pediatrics, University of California, San Diego, La Jolla. AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla. AD - Department of Psychiatry, University of California, San Diego. FAU - Manzano, Michael A AU - Manzano MA AD - Department of Psychiatry, University of California, San Diego. AD - San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego. FAU - Pasquale, Ellen K AU - Pasquale EK AD - Department of Psychiatry, University of California, San Diego. AD - San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego. FAU - Strong, David R AU - Strong DR AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla. FAU - Bernard, Rebecca S AU - Bernard RS AD - Department of Pediatrics, University of California, San Diego, La Jolla. FAU - Rhee, Kyung E AU - Rhee KE AD - Department of Pediatrics, University of California, San Diego, La Jolla. FAU - Eichen, Dawn M AU - Eichen DM AD - Department of Pediatrics, University of California, San Diego, La Jolla. FAU - Miller, Alec AU - Miller A AD - Department of Psychiatry, Albert Einstein College of Medicine, White Plains, New York. FAU - Peterson, Carol B AU - Peterson CB AD - Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis. LA - eng SI - ClinicalTrials.gov/NCT03674944 PT - Journal Article PT - Randomized Controlled Trial DEP - 20261001 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - *Behavior Therapy/methods MH - Body Mass Index MH - *Emotional Eating MH - *Emotional Regulation MH - *Family Therapy/methods MH - *Pediatric Obesity/therapy/psychology MH - Treatment Outcome MH - *Weight Loss MH - *Weight Reduction Programs/methods PMC - PMC13691656 COIS- Conflict of Interest Disclosures: Drs Boutelle, Eichen, and Peterson reported receiving grants from the National Institutes of Health (NIH) during the conduct of the study. No other disclosures were reported. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 PMCR- 2026/10/22 CRDT- 2026/10/23 13:05 PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 13:05 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - 2855701 [pii] AID - zoi261080 [pii] AID - 10.1001/jamanetworkopen.2026.39867 [doi] PST - epublish SO - JAMA Netw Open. 2026 Oct 1;9(10):e2639867. doi: 10.1001/jamanetworkopen.2026.39867. PMID- 42911282 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261027 IS - 1432-1254 (Electronic) IS - 0020-7128 (Linking) VI - 70 IP - 11 DP - 2026 Oct 22 TI - Familiar name, unfamiliar reality: a case study of heat illness knowledge gaps among Japanese junior high and high school students. LID - 282 [pii] LID - 10.1007/s00484-026-03351-w [doi] AB - Early recognition of exertional heat illness (EHI) is critical for preventing severe outcomes. However, the relationship between perceived knowledge and actual understanding remains unclear. This study investigated the recognition and correct matching of EHI and its symptoms among Japanese junior high and high school students. A paper-based, self-administered questionnaire was distributed under conditions of anonymity and voluntary participation. The questionnaire included recognition of the term "EHI" and its condition types and severity classifications (mild, moderate, and severe). EHI knowledge was evaluated by asking students to select all symptoms corresponding to each EHI condition and severity classification from a predefined list, based on previous guidelines. Valid responses were obtained from 533 junior high and 646 high school students. Almost all students recognised the term "EHI," with most reporting school health education as the primary source of learning. However, correct matching of EHI types with their associated symptoms was low (junior high school/high school): 1.9/3.1% for heat syncope, 22.1/26.9% for exercise-associated muscle cramps, 4.1/7.9% for exertional heat exhaustion, and 0.4/0.5% for exertional heat stroke. These results indicate that, although recognition of EHI terminology was nearly universal, correct matching of symptoms was extremely low. These findings reveal a substantial gap between perceived knowledge and actual understanding of EHI. This discrepancy may lead to delayed recognition and inappropriate responses in real-world situations, potentially increasing the risk of adverse outcomes during heat exposure. Addressing this gap may be important for improving safety and public health preparedness in school-based settings. CI - (c) 2026. The Author(s) under exclusive licence to International Society of Biometeorology. FAU - Matsuo, Hiroki AU - Matsuo H AUID- ORCID: 0009-0008-7423-6610 AD - Department of Physical Therapy, Faculty of Rehabilitation, Morinomiya University of Medical Sciences, 559-8611, Osaka, Japan. hmres2507@gmail.com. AD - Department of Advanced Fibro-Sciences, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, Japan. hmres2507@gmail.com. FAU - Yamashita, Naoyuki AU - Yamashita N AUID- ORCID: 0000-0002-8442-8690 AD - Faculty of Arts and Sciences, Kyoto Institute of Technology, 1 Hashikamicho Matsugasaki Sakyoku, 606-8585, Kyoto, Japan. ynaoyuki@kit.ac.jp. LA - eng PT - Journal Article DEP - 20261022 PL - United States TA - Int J Biometeorol JT - International journal of biometeorology JID - 0374716 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - *Health Knowledge, Attitudes, Practice MH - *Heat Stress Disorders/diagnosis MH - Japan MH - Schools MH - *Students/psychology MH - Surveys and Questionnaires OTO - NOTNLM OT - Adolescent health OT - Heat disorders OT - Public health OT - School health education OT - Severity classifications of EHI OT - Student health literacy COIS- Declarations. Ethical approval: This study was approved by Kyoto Institute of Technology Ethics Committee for Scientific Research Involving Human Subjects (approval number: 2024-24) and was conducted in accordance with the tenets of the Declaration of Helsinki. Teachers explained the purpose of the survey orally, and students were informed that completion of the questionnaire was regarded as consent to participate; therefore, written consent was not obtained. Conflict of interest: The authors declare no financial and non-financial interests. Declaration of generative AI in scientific writing: During the preparation of this manuscript, the authors used generative AI tools (e.g., ChatGPT) solely for assistance with grammar and language editing. The authors critically reviewed and edited all AI-assisted content and take full responsibility for the integrity and originality of the manuscript. Preprint disclosure: An earlier version of this manuscript was posted as a preprint on Research Square (DOI: https://doi.org/10.21203/rs.3.rs-5413142/v1 ). The current version expands the original study from 223 to 1179 participants, which enhances the generalisability of our observations. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 CRDT- 2026/10/23 12:49 PHST- 2026/05/09 00:00 [received] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/09/11 00:00 [revised] PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 12:49 [entrez] AID - 10.1007/s00484-026-03351-w [pii] AID - 10.1007/s00484-026-03351-w [doi] PST - epublish SO - Int J Biometeorol. 2026 Oct 22;70(11):282. doi: 10.1007/s00484-026-03351-w. PMID- 42910905 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1536-7290 (Electronic) IS - 1536-7290 (Linking) VI - 26 IP - 11 DP - 2026 Nov TI - Age-Related Patterns of Relative Energy Deficiency in Sport (REDs) Symptoms and Key Performance Factors in Adolescent Biathletes. LID - e70273 [pii] LID - 10.1002/ejsc.70273 [doi] AB - Relative Energy Deficiency in Sport (REDs) impairs health and performance, but age-related patterns in its emergence remain unclear. This study examines RED symptoms in adolescent biathletes at season-start and their link to end-of-season performance. A national cross-sectional study including prospective performance registration recruited biathletes to complete validated questionnaires, followed by clinical interviews if eating disorders (EDs) were indicated. Athletes >/= 18 years were invited for physical laboratory assessments. End-of-season results were retrieved from open records. Analyses were performed by elastic net regression to identify the most stable predictors of performance, which were finally included in a linear regression model. Seventy-two athletes (55% females) with mean (SD) age 17.8 (1.4) years, 13.3 (3.3) training hours/week, and representing median (min, max) tier 3.0 (2, 5) were included. Prevalence in symptoms of low energy availability (LEA) was 18%, REDs 32%, EDs 11% (20% among females), and of depression 15%. Among 28 athletes (43% female) completing laboratory assessments, 11% had low BMD and /= 18 years who completed laboratory testing, 11% had low bone mineral density, and up to 25% showed clinical metabolic abnormalities. Symptoms of REDs and mental health concerns were more common in females and were more prevalent in the older age groups, peaking around 18 years. Better end-of-season performance was linked to higher training volume, fewer absences due to illness or injury, and lower RED severity. Higher body fat percentage and cholesterol levels were associated with poorer results. The findings highlight the importance of regular health screening, education and coaching to safeguard young athletes. OABL- eng OTO - NOTNLM OT - adolescent athletes OT - eating disorders OT - low energy availability OT - mental health OT - performance determinants EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 CRDT- 2026/10/23 12:30 PHST- 2026/09/29 00:00 [revised] PHST- 2026/02/19 00:00 [received] PHST- 2026/10/03 00:00 [accepted] PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 12:30 [entrez] AID - e70273 [pii] AID - 10.1002/ejsc.70273 [doi] PST - ppublish SO - Eur J Sport Sci. 2026 Nov;26(11):e70273. doi: 10.1002/ejsc.70273. PMID- 42910504 OWN - NLM STAT- Publisher LR - 20261023 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Oct 22 TI - Performance of a new regression equation for predicting energy expenditure and its potential for identifying dietary reference values for energy. PG - 1-14 LID - 10.1017/S0007114526108691 [doi] AB - The performance of a prediction equation for total energy expenditure (TEE), derived from a large database of doubly labelled water (DLW) measurements of TEE held at the International Atomic Energy Agency, which has been proposed for estimating population energy requirements (ER) from basic anthropometric data as a replacement for the factorial method, is tested against a dataset of 450 DLW-derived measures of TEE in randomly selected urban US adults aged 40-69 years, and its bias is evaluated. Its performance is also tested by modelling TEE for all ages at the healthy weights identified by the UK Scientific Advisory Committee on Nutrition, (SACN), in its report on dietary reference values (DRV) for energy, and the predicted values for TEE are compared with TEE calculated by the factorial method, as well as with values in a subsequent UK Government report on Dietary Recommendations for Energy, in which values for adolescents and for adults were capped at below their predicted values to help address issues of overweight and obesity. Whilst the prediction equation for TEE is accurate ( 0.7). Mean scores for all 18 items denoted no perceived influence, with 55.0-76.8% of respondents reporting no effect on their food-related attitudes and practices. Girls scored higher than boys for following nutrition-related content (p < 0.05) and for the increase in the desire to eat (p = 0.048); differences also emerged by place of residence (p = 0.041) and school attended (p = 0.008; p = 0.004). CONCLUSION: Adopted version of the SESMEB scale is a reliable instrument for assessing the perceived effects of social media on adolescent eating behavior. Most respondents reported no such influence, even though this population is intensively exposed to digital marketing of energy-dense products, suggesting that self-report may underestimate the actual effect of that exposure. CI - Copyright (c) 2026 Stojisavljevic, Jotic Ivanovic, Mijovic, Nikolic, Niskanovic and Joksimovic. FAU - Stojisavljevic, Dragana AU - Stojisavljevic D AD - Department of Nutrition, The Public Health Institute of Republic of Srpska, Banja Luka, Bosnia and Herzegovina. AD - Department of Public Health, Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. FAU - Jotic Ivanovic, Marina AU - Jotic Ivanovic M AD - Department of Family Medicine, Primary Health Care Centre, Doboj, Bosnia and Herzegovina. FAU - Mijovic, Biljana AU - Mijovic B AD - Department of Primary Health Care and Public Health, Faculty of Medicine, University of East Sarajevo, Foca, Bosnia and Herzegovina. FAU - Nikolic, Maja AU - Nikolic M AD - Department of Social Medicine, Faculty of Medicine, University of Nis, Nis, Serbia. FAU - Niskanovic, Jelena AU - Niskanovic J AD - Department of Psychology, Faculty of Philosophy, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. FAU - Joksimovic, Bojan AU - Joksimovic B AD - Department of Preclinical Subjects (Pathological Physiology), Faculty of Medicine, University of East Sarajevo, Foca, Bosnia and Herzegovina. LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13683706 OTO - NOTNLM OT - SESMEB questionnaire OT - adolescents OT - eating behavior OT - food marketing OT - social networks COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/23 11:32 MHDA- 2026/10/23 11:33 PMCR- 2026/10/07 CRDT- 2026/10/23 07:21 PHST- 2026/07/12 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/23 11:33 [medline] PHST- 2026/10/23 11:32 [pubmed] PHST- 2026/10/23 07:21 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - 10.3389/fnut.2026.1935743 [doi] PST - epublish SO - Front Nutr. 2026 Oct 7;13:1935743. doi: 10.3389/fnut.2026.1935743. eCollection 2026. PMID- 42908925 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261024 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Feasibility of exercise training to address corticosteroid-induced changes in adolescents aged 10+ with lymphoma or leukemia during the first eight weeks of treatment: a pilot study. PG - 1819451 LID - 10.3389/fped.2026.1819451 [doi] LID - 1819451 AB - INTRODUCTION: Children and adolescents with hematological malignancies are at risk of adverse side effects from high-dose corticosteroid treatment during induction therapy. In this context, exercise and nutrition interventions are promising, physiologically grounded approaches but their feasibility and practical delivery during early intensive therapy remain unclear. Therefore, this prospective pilot randomized controlled trial was designed to evaluate the feasibility and preliminary effects of an exercise intervention and nutrition consultation in newly diagnosed patients. METHODS: Participants with leukemia or lymphoma, aged 10-17 years, were allocated to an 8-week exercise or sham control intervention (stratified randomization, 1:1 ratio, parallel groups) plus one-time nutrition counseling. Feasibility outcomes included recruitment, retention, adherence, safety, completion of assessments, and subjective feedback from patients and personnel involved in the study. Furthermore, repeated measures of physical performance, functional capacity, metabolic health, and body composition were used to explore baseline status and changes over time, after four and eight weeks of therapy. RESULTS: Six participants, two of which were allocated to the intervention group, completed the trial. Overall rates of consent (67%), training adherence (51%) and complete measures (70%) did not attain prespecified criteria (>/=80%). Despite considerable variability, pilot data indicated reduced physical capacity and functioning inferior to healthy norms at baseline and over the course of the intervention including hand grip strength (DeltaZ +/- SD = -1.5 +/- 1.4), cardiorespiratory fitness (steep ramp cycle ergometry peak power; DeltaZ +/- SD = -3.8 +/- 1.2), and lower extremity muscle strength (5-times sit-to-stand test; DeltaZ +/- SD = 2.3 +/- 2.0), while having mostly normal quadriceps muscle and abdominal fat thickness and erratic unfavorable metabolic states. No formal exploration of intervention effects was performed. DISCUSSION: Limited feasibility opposed continuation to a definite trial. Respective challenges observed may reflect particularities of early treatment, thus, substantial changes are advised for future protocols (e.g., towards a more adaptive trial design). Besides their limited generalizability and variability, pilot data suggests that adolescents undergoing induction therapy can experience intermittent deconditioning, while other outcomes were inconclusive. Thus, future exercise interventions should account for various objections to exercise participation, heterogeneous medical conditions, and potentially impaired physical capacity and functioning, especially during early therapy. CLINICAL TRIAL REGISTRATION: https://drks.de/search/de/trial/DRKS00032259, identifier DRKS00032259. CI - (c) 2026 Blumer, Erhard, Schanda, Tomaskovic and Dieckelmann. FAU - Blumer, Vera AU - Blumer V AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. FAU - Erhard, Sarah AU - Erhard S AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. FAU - Schanda, Nicola AU - Schanda N AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. FAU - Tomaskovic, Aleksandar AU - Tomaskovic A AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. FAU - Dieckelmann, Mirjam AU - Dieckelmann M AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. LA - eng PT - Clinical Trial PT - Journal Article DEP - 20261007 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13683610 OTO - NOTNLM OT - body composition OT - child OT - exercise therapy OT - leukemia OT - lymphoma OT - pediatric oncology OT - physical functioning OT - pilot study COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/23 11:32 MHDA- 2026/10/23 11:33 PMCR- 2026/10/07 CRDT- 2026/10/23 05:13 PHST- 2026/02/27 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/23 11:33 [medline] PHST- 2026/10/23 11:32 [pubmed] PHST- 2026/10/23 05:13 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - 10.3389/fped.2026.1819451 [doi] PST - epublish SO - Front Pediatr. 2026 Oct 7;14:1819451. doi: 10.3389/fped.2026.1819451. eCollection 2026. PMID- 42908670 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261025 IS - 2773-0654 (Electronic) IS - 2773-0654 (Linking) VI - 5 IP - 6 DP - 2026 Dec TI - Beyond Accuracy: Machine Learning Models for Predicting the Presence of Permanent Molar Caries in U.S. Children and Adolescents With Fairness Consideration. PG - 100506 LID - 10.1016/j.focus.2026.100506 [doi] LID - 100506 AB - INTRODUCTION: Although predictors of dental caries have been previously explored, a comprehensive understanding of factors influencing permanent-molar decay in U.S. children and adolescents, especially with respect to racial and ethnic biases, remains limited. This study aims to develop and evaluate machine learning models incorporating algorithmic fairness to predict caries in permanent molars. METHODS: Data from the National Health and Nutrition Examination Survey were analyzed using the 2011-2014 cycles for training and validation and the 2015-2016 cycle for testing. The primary outcome was decayed, missing, and filled teeth in at least 1 permanent molar, dichotomized to represent the presence or absence of caries. Candidate predictors included demographic characteristics, dietary factors, laboratory and examination measures, behaviors, and lifestyle indicators. Three machine learning models (logistic regression, random forest, and XGBoost) were implemented and compared using the area under the receiver operating characteristic curve, accuracy, sensitivity, and specificity. Fairness was quantified by comparing group-specific true-positive rates and false-positive rates across race/ethnicity over 10 cross-validation folds, using Shapiro-Wilk tests and paired tests to assess subgroup gaps and pre/postmitigation changes. To mitigate disparities, an in-processing equalized-odds constraint was applied through an exponentiated-gradient reduction framework. Sensitivity analyses using National Health and Nutrition Examination Survey weights were also conducted. RESULTS: Among 5,710 participants aged 6-19 years, 37.30% had caries in at least 1 permanent molar. Logistic regression achieved the highest premitigation area under the receiver operating characteristic curve (78.50%). SHAP (SHapley Additive exPlanations) analyses identified age, family income, BMI, and household education as key contributors. Fairness evaluation indicated minimal equal-opportunity gaps but showed evidence of equalized-odds violations across race/ethnicity. After mitigation, race/ethnicity-related disparities decreased across models, with varying performance trade-offs. XGBoost and random forest maintained stable area under the receiver operating characteristic curve values in both unweighted ( approximately 77%-78%) and survey-weighted ( approximately 75%-77%) evaluations. In contrast, logistic regression showed a substantial decline in unweighted area under the receiver operating characteristic curve (78.50%-65.53%) and a marked reduction in recall and F1 score, whereas changes under weighted evaluation were more modest (77.91%-76.54%). CONCLUSIONS: Machine learning models effectively predicted dental caries in children and adolescents using National Health and Nutrition Examination Survey data. Applying equalized-odds constraints reduces disparities across models, although with varying fairness-performance trade-offs. These findings highlight the importance of tailoring bias mitigation strategies to clinical priorities, balancing equitable outcomes and predictive utility, and they can be used to inform policy and better design-targeted interventions to improve oral health. CI - (c) 2026 The Author(s). FAU - Deb, Pritam AU - Deb P AD - Department of Industrial and Systems Engineering, Kennesaw State University, Marietta, Georgia. FAU - Li, Lin AU - Li L AD - Department of Industrial and Systems Engineering, Kennesaw State University, Marietta, Georgia. FAU - Scherrer, Christina R AU - Scherrer CR AD - Department of Industrial and Systems Engineering, Kennesaw State University, Marietta, Georgia. LA - eng GR - R15 DE031428/DE/NIDCR NIH HHS/United States GR - R21 DE032149/DE/NIDCR NIH HHS/United States PT - Journal Article DEP - 20260509 PL - United States TA - AJPM Focus JT - AJPM focus JID - 9918487585606676 PMC - PMC13683022 OTO - NOTNLM OT - Dental caries OT - children and adolescents OT - fairness OT - machine learning OT - prediction EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/05/09 CRDT- 2026/10/23 02:36 PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 02:36 [entrez] PHST- 2026/05/09 00:00 [pmc-release] AID - S2773-0654(26)00032-5 [pii] AID - 100506 [pii] AID - 10.1016/j.focus.2026.100506 [doi] PST - epublish SO - AJPM Focus. 2026 May 9;5(6):100506. doi: 10.1016/j.focus.2026.100506. eCollection 2026 Dec. PMID- 42908574 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261024 IS - 2399-3529 (Electronic) IS - 2399-3529 (Linking) VI - 2026 IP - 4 DP - 2026 TI - In vitro incubation of human sperm does not change DNA methylation. PG - hoag079 LID - 10.1093/hropen/hoag079 [doi] LID - hoag079 AB - STUDY QUESTION: Is DNA methylation in mature spermatozoa affected by different culture media? SUMMARY ANSWER: Incubation of mature spermatozoa in hydrogen peroxide (H(2)O(2)) or palmitate for 24 h did not alter the DNA methylome. WHAT IS KNOWN ALREADY: Children conceived through ART face a higher risk of disorders linked to abnormal DNA methylation. As culture media can modulate DNA methylation in somatic cells, abnormal DNA methylation after ART may be caused by factors present in culture media during sperm incubation. STUDY DESIGN SIZE DURATION: Sperm from four donors underwent targeted shotgun proteomics analysis, focusing on protein size ranges that include epigenetic modifying enzymes. Additionally, sperm samples from 15 men were incubated for 24 h in either standard media, media with H(2)O(2), or media containing palmitate, two media known to induce acute DNA methylation changes in somatic cells. DNA methylation profiles of these incubated sperm samples were then compared to those of pre-incubation sperm using Reduced Representation Bisulfite Sequencing (RRBS). PARTICIPANTS/MATERIALS SETTING METHODS: Sperm samples were obtained from 15 healthy Caucasian men aged 20-40 years. Participants using prescription medications daily or with a history of testicular disease were excluded. Motile sperm were isolated through the swim-up technique. Protein analysis was conducted via in-gel digestion followed by mass spectrometry. DNA methylation was evaluated using RRBS and validated for select genomic regions with targeted bisulfite pyrosequencing. MAIN RESULTS AND THE ROLE OF CHANCE: Proteomic analysis returned 1930 proteins, including 144 newly identified proteins. Consistent with previous studies, we confirmed the presence of DNA methyltransferase 1 (DNMT1), while de novo methyltransferases DNMT3A and DNMT3B were not detected. Incubation in control, H(2)O(2), and palmitate media all led to decreased sperm motility, with the decline occurring the fastest under the H(2)O(2) condition. Sperm DNA methylation remained unchanged across all three culture conditions. LARGE SCALE DATA: N/A. LIMITATIONS REASONS FOR CAUTION: RRBS analysis covers only a portion of the genome, so DNA methylation changes in unexamined regions cannot be excluded, particularly at repeated regions of the genome. Moreover, since this study tested only three culture media conditions, it remains possible that other media formulations could impact DNA methylation. WIDER IMPLICATIONS OF THE FINDINGS: This study indicates that the DNA methylome of mature human spermatozoa is stable despite the presence of DNA methylation machinery components. These results imply that DNA methylation changes in response to environmental stress are more likely to happen during earlier stages of spermatogenesis. While the various culture media used in ART are unlikely to alter the DNA methylation patterns of individual sperm cells, the possibility that certain sperm with specific methylation signatures are selectively favored cannot be ruled out. FUNDING: This work was supported by a Challenge Programme Grant from the Novo Nordisk Foundation (NNF18OC0033754) to the Gametic Epigenetics Consortium against Obesity (GECKO). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research center at the University of Copenhagen, partially funded by an unrestricted donation from the Novo Nordisk Foundation (NNF18CC0034900). This work was supported by the French Government (National Research Agency, ANR) through the 'Investments for the Future' programs LABEX SIGNALIFE ANR-11-LABX-0028-01 and IDEX UCAJedi ANR-15-IDEX-01. DISCLOSURES: R.B. is a recipient of research funding granted by the Novo Nordisk Foundation. E.A. is a shareholder of ExSeed Health Ltd. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. FAU - Kjoller, Emma Tykesson AU - Kjoller ET AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Dumargne, Marie-Charlotte AU - Dumargne MC AD - Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Inserm and Universite Cote d'Azur, Valbonne, France. FAU - Ingerslev, Lars Roed AU - Ingerslev LR AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Manitta, Eleonora AU - Manitta E AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Dehestani, Yasmin AU - Dehestani Y AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Saupstad, Marte AU - Saupstad M AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Gonzalez-Franquesa, Alba AU - Gonzalez-Franquesa A AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Deshmukh, Atul Shahaji AU - Deshmukh AS AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Andersen, Emil AU - Andersen E AUID- ORCID: 0000-0001-6009-2099 AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - ExSeed Health ApS, Copenhagen, Denmark. FAU - Barres, Romain AU - Barres R AUID- ORCID: 0000-0002-0158-519X AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Inserm and Universite Cote d'Azur, Valbonne, France. LA - eng PT - Journal Article DEP - 20260911 PL - England TA - Hum Reprod Open JT - Human reproduction open JID - 101722764 PMC - PMC13682945 OTO - NOTNLM OT - ART OT - DNA methylation OT - bisulfite sequencing OT - epigenetics OT - spermatozoa EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/09/11 CRDT- 2026/10/23 01:13 PHST- 2025/11/17 00:00 [received] PHST- 2026/08/11 00:00 [revised] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 01:13 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - hoag079 [pii] AID - 10.1093/hropen/hoag079 [doi] PST - epublish SO - Hum Reprod Open. 2026 Sep 11;2026(4):hoag079. doi: 10.1093/hropen/hoag079. eCollection 2026. PMID- 42908560 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261024 IS - 2633-4402 (Electronic) IS - 2633-4402 (Linking) VI - 6 DP - 2026 TI - Designing a context-specific intervention in practice: learning from a school-based physical activity intervention. PG - 78 LID - 10.3310/nihropenres.14336.2 [doi] LID - 78 AB - BACKGROUND: Public health interventions need to be designed for the intervention setting. Traditionally, to maximise internal validity, school-based pupil physical activity interventions deliver an identical programme across all settings. However, an interventions' success will depend on the context in which it is implemented, i.e. a schools' social, cultural, economic, environmental and other characteristics. In this paper we use the development of the PASSPORT (Physical Activity via a School-Specific PORTfolio) intervention as a case study for the development of context-specific public health interventions. We outline how we developed the intervention and draw out key learning from this for public health interventions generally. METHODS: The PASSPORT intervention takes a portfolio approach that allows schools to select and deliver tailored intervention content that is most suitable to their setting. The intervention was developed across multiple research steps that were designed to progressively build knowledge on school context and physical activity and integrate these into intervention design. We outline these in the paper. Formative studies include: a scoping review of intervention components; school staff interviews; a rapid ethnography; and a school survey. These findings informed the co-design of the intervention tool with primary school staff and the development of the portfolio content. Finally, we conducted a pilot study in two schools to learn from both the delivery of the intervention and associated evaluation data collection. KEY LEARNING: Key learning for context-specific intervention design has been gathered around four areas: Ground intervention design in a range of data and insight, Centre contextual experience, Design for intervention flexibility and user autonomy, and, Build in processes to test and iterate. CONCLUSIONS: Each of the formative studies and the intervention design steps provided parts of the complex picture of intervention context and design needs. Combined, the results of the studies supported the development of a context-specific intervention. CI - Copyright: (c) 2026 House D et al. FAU - House, Danielle AU - House D AUID- ORCID: 0000-0001-6171-9922 AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Howard, Abi AU - Howard A AUID- ORCID: 0009-0005-0613-3028 AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Kent-Saisch, Simona AU - Kent-Saisch S AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Porter, Alice AU - Porter A AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. AD - NIHR Bristol Biomedical Research Centre, Bristol, England, UK. FAU - Reid, Tom AU - Reid T AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Morbey, Roger AU - Morbey R AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Emm-Collison, Lydia AU - Emm-Collison L AD - Centre for Exercise, Nutrition & Health Sciences, University of Bristol, Bristol, England, UK. FAU - de Vocht, Frank AU - de Vocht F AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Salway, Ruth AU - Salway R AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Jago, Russell AU - Jago R AUID- ORCID: 0000-0002-3394-0176 AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. AD - NIHR Bristol Biomedical Research Centre, Bristol, England, UK. LA - eng PT - Journal Article DEP - 20261008 PL - England TA - NIHR Open Res JT - NIHR open research JID - 9918333281906676 PMC - PMC13680835 OAB - WHAT THIS PAPER IS ABOUT: Programmes designed to support people's health need to be appropriate for the specific community they serve. For example, schools are a great place to support lots of children to be more active, but a programme needs to fit into the day-to-day life of a school for it to work well. Usually, health programmes are the same in each setting. But each setting is different, with different resources, people, equipment, and cultures. In this paper we describe how we designed a flexible programme that would be different in each school setting. We outline the steps we took to develop the programme and draw out key learning from this, to help other researchers who want to develop similar programmes. WHAT WE DID: We did several smaller projects to build up the information we needed to develop the flexible programme. These are described in the paper and include looking at current academic literature, doing interviews with school staff, spending lots of time in three schools, and doing a survey with many schools. We then took our learning from these projects to design the programme in workshops with school staff, and we used school knowledge and staff to develop the activities that make up the overall programme. We then tried out the intervention in two schools to learn from this. WHAT WE LEARNT: We learnt several key lessons that would be useful for other researchers who want to design a similar programme. 1) It was useful to have such a range of information to bring into the programme. 2) It was important to have the users, the people who would deliver the programme, at the centre of the programme development. 3) Designing the programme to be flexible was helpful, so that it could be different in each setting, and it was good for schools to be the decision-makers in this. 4) It was necessary to try out and improve the programme lots of times. OABL- eng OTO - NOTNLM OT - complex interventions OT - context OT - interventions OT - physical activity OT - public health OT - schools OT - settings COIS- No competing interests were disclosed. EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/10/08 CRDT- 2026/10/23 00:51 PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 00:51 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 10.3310/nihropenres.14336.2 [doi] PST - epublish SO - NIHR Open Res. 2026 Oct 8;6:78. doi: 10.3310/nihropenres.14336.2. eCollection 2026. PMID- 42908542 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261024 IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 17 DP - 2026 TI - Psychiatric comorbidities in pediatric epilepsy: a single-center retrospective study highlighting the burden of depressive symptoms. PG - 1951989 LID - 10.3389/fneur.2026.1951989 [doi] LID - 1951989 AB - INTRODUCTION: Epilepsy in the pediatric population is frequently associated with psychiatric comorbidities. Depression is of particular clinical significance given its elevated incidence and substantial impact on quality of life, treatment adherence, and psychosocial functioning. The prevalence of depression in children with epilepsy ranges from 7% to 14%, considerably higher than the 1-5% reported in the general pediatric population. The relationship between epilepsy and depression appears bidirectional: epilepsy predisposes to depressive disorders, and depression may increase seizure risk, suggesting shared neurobiological pathways. This study aimed to assess the prevalence of psychiatric symptoms in pediatric patients with epilepsy, with particular focus on depressive symptomatology, and to examine associations with etiological and clinical variables. METHODS: This retrospective study included 240 pediatric patients (aged 2-18 years) diagnosed with epilepsy between 2013 and 2024. Psychiatric symptoms were ascertained retrospectively from clinical records. Patients were categorized into two groups: those with an identified genetic and/or structural abnormality (G1, n = 60) and those without (G2, n = 180). Statistical analysis employed the chi-squared test and Student's t-test (p < 0.05). RESULTS: Psychiatric symptoms were identified in 30% of patients (72/240, 95% CI 24.2-35.8%). The most prevalent disorder was attention-deficit/hyperactivity disorder (ADHD; n = 30), followed by sleep disturbance/asthenia (n = 19), aggression/temper tantrums (n = 13), depressive/mood symptoms (n = 11), anxiety symptoms (n = 10), autism spectrum disorder (n = 6), eating behavior alterations (n = 4), self-harm (n = 4), adjustment/self-esteem features (n = 3), obsessive-compulsive disorder (OCD; n = 3), panic attacks (n = 2), and suicide attempts (n = 2). Psychiatric symptoms were significantly more prevalent in G1 (42%, 95% CI 29.2-54.1%) than in G2 (26%, 95% CI 19.7-32.5%; p = 0.03), corresponding to an odds ratio of 2.02 (95% CI 1.10-3.72). No significant associations were found between psychiatric symptoms and age, sex, family history, or treatment regimen. DISCUSSION: Psychiatric comorbidities, including depressive symptomatology, are common in pediatric epilepsy and likely associated with underlying neurobiological factors. These findings support integrating neuropsychiatric screening, using validated instruments such as the Children's Depression Inventory-2 (CDI-2) and the Neurological Disorders Depression Inventory for Epilepsy-Youth version (NDDI-E-Y), into routine epilepsy care. CI - Copyright (c) 2026 De Leonardis, Spalice, Verrotti, De Rosa and Aloisio. FAU - De Leonardis, Arianna AU - De Leonardis A AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. AD - Department of Pediatrics, University of Perugia, Perugia, Italy. FAU - Spalice, Alberto AU - Spalice A AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. FAU - Verrotti, Alberto AU - Verrotti A AD - Department of Pediatrics, University of Perugia, Perugia, Italy. FAU - De Rosa, Isabella AU - De Rosa I AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. FAU - Aloisio, Simone AU - Aloisio S AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 SB - IM MH - Humans MH - Child MH - Retrospective Studies MH - Female MH - *Epilepsy/epidemiology/psychology/complications MH - Male MH - Adolescent MH - Comorbidity MH - Child, Preschool MH - *Depression/epidemiology MH - Prevalence MH - Attention Deficit Disorder with Hyperactivity/epidemiology PMC - PMC13683009 OTO - NOTNLM OT - ADHD OT - depression OT - epilepsy OT - pediatrics OT - psychiatric comorbidity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors AS, AV declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/10/07 CRDT- 2026/10/23 00:36 PHST- 2026/07/29 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 00:36 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - 10.3389/fneur.2026.1951989 [doi] PST - epublish SO - Front Neurol. 2026 Oct 7;17:1951989. doi: 10.3389/fneur.2026.1951989. eCollection 2026. PMID- 42908020 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261022 LR - 20261024 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 18 IP - 1 DP - 2026 Jul 27 TI - Comparison of the effects of aquatic HIIT and MICT on central hemodynamics, endothelial function, and aerobic fitness in obese school-aged children: a randomized controlled trial. LID - 10.1186/s13102-026-01918-z [doi] LID - 517 AB - BACKGROUND: Aquatic exercise may be a feasible strategy for improving cardiovascular health in children with obesity, but evidence comparing aquatic high-intensity interval training (aHIIT) and aquatic moderate-intensity continuous training (aMICT) remains limited. This pilot randomized controlled trial compared the effects of 8 weeks of aHIIT and aMICT on endothelial function, estimated cardiorespiratory fitness, central hemodynamic indices, arterial stiffness, and anthropometric indicators in school-aged children with obesity. METHODS: Thirty-three children with obesity were randomized to the aHIIT group (n = 11), aMICT group (n = 11), or non-exercise control group (n = 11). The two aquatic exercise groups trained 3 days/week for 8 weeks. The aHIIT protocol consisted of 10 x 30-s high-intensity aquatic exercise (such as freestyle swimming or freestyle kicking) bouts at 80%-90% HRmax, separated by 60-s recovery intervals, whereas the aMICT protocol consisted of two 15-min continuous breaststroke bouts at 60%-70% HRmax, separated by a 5-min recovery interval. Brachial artery flow-mediated dilation (FMD) was used as the principal vascular outcome. Central hemodynamic indices were assessed using applanation tonometry, and estimated VO(2max) was obtained from the 20-m shuttle run test. Intervention effects were analyzed using two-way repeated-measures ANOVA, with the group x time interaction used as the primary test for differential intervention effects. RESULTS: Significant group x time interactions were observed for estimated VO(2max), FMD, AIx, and AIx@HR75. Estimated VO(2max) increased in both aquatic exercise groups compared with the control group. FMD improved in both exercise groups, with a greater increase observed after aHIIT. AIx and AIx@HR75 showed favorable changes after aMICT. No significant group x time interactions were observed for resting blood pressure, SEVR, ABI, cfPWV, or baPWV. CONCLUSION: This pilot trial suggests that both aHIIT and aMICT may improve estimated cardiorespiratory fitness in school-aged children with obesity. aHIIT may be associated with greater improvement in brachial artery endothelial function, whereas aMICT may have favorable effects on selected wave-reflection-related indices. However, these findings should be interpreted cautiously because of the small sample size, indirect estimated VO(2max) estimation, lack of maturation assessment, and unmatched exercise workload. TRIAL REGISTRATION: Chinese Clinical Trial Registration, ChiCTR2400080687.05/02/2024. CI - (c) 2026. The Author(s). FAU - Huang, Junhao AU - Huang J AD - Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, China. junhaohuang2006@hotmail.com. AD - Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China. junhaohuang2006@hotmail.com. AD - Scientific Research Center, Guangzhou Sport University, 1268 Middle Guangzhou Avenue, Guangzhou, 510500, China. junhaohuang2006@hotmail.com. FAU - Huang, Weiwei AU - Huang W AD - Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, China. FAU - Zheng, Yongpeng AU - Zheng Y AD - Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, China. FAU - Lu, Weishan AU - Lu W AD - Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, China. FAU - Wang, Shen AU - Wang S AD - Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, China. FAU - Hu, Min AU - Hu M AD - Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, Guangdong, China. minhu@gzsport.edu.cn. AD - Scientific Research Center, Guangzhou Sport University, 1268 Middle Guangzhou Avenue, Guangzhou, 510500, China. minhu@gzsport.edu.cn. LA - eng GR - 2023ZDZX2033/Guangdong Scientific Research Platform and Projects for the Higher-educational Institution/ PT - Journal Article DEP - 20260727 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC13689059 OTO - NOTNLM OT - Aquatic exercise OT - High-intensity interval training OT - Moderate-intensity continuous training OT - Obese school-aged children OT - Vascular function COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of Guangzhou Sport University (2024LCLL-04) and registered in Chinese Clinical Trial Registry (ChiCTR2400080687||2024-02-05). The study was conducted in accordance with the Declaration of Helsinki. This study complies with CONSORT guidelines. Prior to participation, each participant's guardian voluntarily signed a written informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:30 PMCR- 2026/07/27 CRDT- 2026/10/22 22:42 PHST- 2026/02/05 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/10/22 23:30 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 22:42 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.1186/s13102-026-01918-z [pii] AID - 1918 [pii] AID - 10.1186/s13102-026-01918-z [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2026 Jul 27;18(1):517. doi: 10.1186/s13102-026-01918-z. PMID- 42907990 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261026 IS - 1471-230X (Electronic) IS - 1471-230X (Linking) VI - 26 IP - 1 DP - 2026 Jul 27 TI - Influencing factors and individualized intervention strategies for inadequate bowel preparation before colonoscopy in high-risk populations: a review based on the clinical practice of painless colonoscopy in China. LID - 10.1186/s12876-026-05161-1 [doi] LID - 688 AB - BACKGROUND: Inadequate bowel preparation (IBP) significantly reduces the diagnostic accuracy of painless colonoscopy and increases complication risks. High-risk populations account for 28% of painless colonoscopy cases in China, with IBP rates ranging from 42% to 62%, but targeted nursing interventions remain underdeveloped. OBJECTIVE: To systematically analyze IBP-related influencing factors and evaluate the effectiveness of individualized nursing interventions for high-risk populations undergoing painless colonoscopy in China. METHODS: Literature searches were conducted across the MEDLINE (via the PubMed interface, Cochrane Library, Embase, CNKI, Wanfang Data, and VIP from January 2020 to April 2024 using keywords related to bowel preparation, high-risk populations, and nursing intervention. Studies on Chinese high-risk populations undergoing painless colonoscopy were eligible if they reported IBP rate, bowel preparation score, or intervention adherence. RCTs, systematic reviews, and clinical guidelines were included. Two reviewers independently screened records, extracted data, and assessed methodological quality using the Cochrane Risk of Bias Tool, JBI Critical Appraisal Checklist, and AGREE II Instrument. Data synthesis involved descriptive analysis and random-effects meta-analysis. RESULTS: A total of 43 studies (32 RCTs, 7 systematic reviews, 4 guidelines) were included. Six high-risk populations were identified: obese patients (BMI >/= 28 kg/m(2)), patients with abdominal/pelvic surgery history, neurological disease patients, long-term medication users, children, and diabetic patients. Key influencing factors included gastrointestinal motility disorders, psychological anxiety, and medication interactions. Individualized interventions (e.g., dose-adjusted laxatives, nurse-led psychological counseling) reduced IBP rates by 23%-48% (pooled OR = 0.36, 95%CI:0.29-0.45, I(2)=45%). CONCLUSION: IBP in high-risk populations is driven by multi-dimensional factors. Context-adapted nursing interventions (e.g., WeChat-guided education, parental participation training) significantly improve preparation quality. Standardized protocols for primary hospitals and child-specific regimens are urgently needed. These findings translate into a risk-stratified, nurse-pharmacist-led preparation pathway that can be implemented immediately-especially in primary hospitals-to reduce IBP and improve safety. And these findings pertain to six high-risk populations-obese, post-surgical, neurological disease, long-term medication users, children, and diabetics-as predefined in the Introduction. CI - (c) 2026. The Author(s). FAU - Lai, Huibin AU - Lai H AD - The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China. FAU - Sun, Ting AU - Sun T AD - The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China. 1195037@zju.edu.cn. FAU - Yu, Xiujing AU - Yu X AD - The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China. 2187007@zju.edu.cn. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20260727 PL - England TA - BMC Gastroenterol JT - BMC gastroenterology JID - 100968547 RN - 0 (Cathartics) SB - IM MH - Humans MH - China MH - *Colonoscopy/nursing/methods MH - *Cathartics/administration & dosage MH - Risk Factors MH - *Preoperative Care/nursing/methods PMC - PMC13688862 OTO - NOTNLM OT - Bowel Preparation OT - Colonoscopy OT - High-risk populations OT - Nursing Intervention OT - Systematic Review COIS- Declarations. Ethics approval and consent to participate: This study is a systematic review that synthesizes data from previously published studies (RCTs, systematic reviews, and guidelines). No original human subjects research was conducted, so formal ethical approval from an Institutional Review Board (IRB) or Approval Committee is not applicable. For the included primary studies (e.g., the 32 RCTs), informed consent from participants was obtained by the original study teams, as required by their respective IRB approvals. This systematic review did not involve direct interaction with human participants, and thus no additional consent to participate was needed. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:30 PMCR- 2026/07/27 CRDT- 2026/10/22 22:36 PHST- 2025/10/14 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/10/22 23:30 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 22:36 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.1186/s12876-026-05161-1 [pii] AID - 5161 [pii] AID - 10.1186/s12876-026-05161-1 [doi] PST - epublish SO - BMC Gastroenterol. 2026 Jul 27;26(1):688. doi: 10.1186/s12876-026-05161-1. PMID- 42907746 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261024 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Jul 24 TI - Perceived fatalism regarding possible COVID-19 infection and its association with self-reported comorbidities in 12 Latin American countries. LID - 10.1186/s12879-026-14042-7 [doi] LID - 1852 AB - INTRODUCTION: The COVID-19 pandemic has had substantial mental health consequences worldwide. However, evidence on perceived fatalism regarding possible COVID-19 infection, particularly in relation to self-reported comorbidities, remains limited in Latin America. OBJECTIVE: To assess perceived fatalism regarding possible COVID-19 infection and its association with self-reported comorbidities among participants recruited in 12 Latin American countries. METHODS: This multicenter analytical cross-sectional study used a non-probability online snowball sampling strategy from June to August 2020. The study included 6,530 participants from Peru, Chile, Paraguay, Mexico, Colombia, Bolivia, Panama, Ecuador, Costa Rica, El Salvador, Honduras, and Guatemala. Perceived fatalism was assessed using five items from a previously developed COVID-19 fatalism scale. The five-item overall score was the primary measure, whereas domain-specific analyses were considered exploratory because of their lower reliability. Self-reported respiratory disease, cardiac disease, diabetes mellitus, obesity, and other illnesses were analyzed as exposure variables. Adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated using generalized linear models from the Poisson family with log link and robust variance. RESULTS: The median age was 22 years (IQR: 19-28), 58.8% of participants were female, 25.3% reported at least one comorbidity, and 55.0% of the sample was recruited in Peru. The five-item fatalism scale showed acceptable internal consistency (Cronbach's alpha = 0.707; McDonald's omega/Raykov's rho = 0.721). In adjusted models, high overall fatalism was more prevalent among participants reporting respiratory disease (aPR 1.17, 95% CI 1.05-1.30), cardiac disease (aPR 1.25, 95% CI 1.08-1.44), diabetes mellitus (aPR 1.32, 95% CI 1.09-1.61), obesity (aPR 1.23, 95% CI 1.10-1.37), and other illnesses (aPR 1.26, 95% CI 1.15-1.39). Men had a lower prevalence of high overall fatalism (aPR 0.88, 95% CI 0.83-0.94). Sensitivity analyses yielded materially similar estimates. CONCLUSIONS: In this non-probabilistic sample from 12 Latin American countries, self-reported comorbidities were associated with a modestly higher prevalence of perceived fatalism regarding possible COVID-19 infection. These findings should be interpreted as exploratory and hypothesis-generating, given the cross-sectional design, self-reported exposures, potential residual confounding, and the young, Peru-predominant, non-probability sample. They should not be interpreted as nationally representative estimates or as evidence of causal relationships. CI - (c) 2026. The Author(s). FAU - Mejia, Christian R AU - Mejia CR AUID- ORCID: 0000-0002-5940-7281 AD - Universidad de Huanuco, Huanuco, Peru. FAU - Vega-Useche, Camilo AU - Vega-Useche C AUID- ORCID: 0000-0002-7064-1765 AD - Fundacion Santa Fe de Bogota, Bogota, Colombia. acamilovega@gmail.com. AD - Universidad Pedagogica y Tecnologica de Colombia, Tunja, Colombia. acamilovega@gmail.com. FAU - Serna-Alarcon, Victor AU - Serna-Alarcon V AUID- ORCID: 0000-0002-9803-6217 AD - Universidad Privada Antenor Orrego, Piura, Peru. AD - Hospital de la Amistad Peru Corea Santa Rosa II-2, Piura, Peru. FAU - Cedillo-Balcazar, Jamil AU - Cedillo-Balcazar J AUID- ORCID: 0000-0003-1468-0628 AD - Direccion Provincial de Salud de Loja, Ministerio de Salud Publica, Loja, Ecuador. FAU - Chamorro-Espinoza, Scherlli E AU - Chamorro-Espinoza SE AUID- ORCID: 0000-0003-1412-3872 AD - Asociacion Medica de Investigacion y Servicios en Salud, Lima, Peru. FAU - Yanez, Jaime A AU - Yanez JA AUID- ORCID: 0000-0002-9713-1829 AD - Escuela de Posgrado, Universidad Internacional Iberoamericana, Campeche, Mexico. FAU - Davies, Neal M AU - Davies NM AUID- ORCID: 0000-0002-7050-1471 AD - University of Alberta, Edmonton, Canada. FAU - Useche-Villamizar, Dalia AU - Useche-Villamizar D AUID- ORCID: 0000-0003-0594-023X AD - Universidad Pedagogica y Tecnologica de Colombia, Tunja, Colombia. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260724 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Humans MH - Female MH - *COVID-19/psychology/epidemiology/mortality MH - Male MH - Latin America/epidemiology MH - Cross-Sectional Studies MH - Adult MH - Self Report MH - Comorbidity MH - Middle Aged MH - Young Adult MH - SARS-CoV-2 MH - Adolescent MH - Aged PMC - PMC13688888 OTO - NOTNLM OT - COVID-19 OT - Comorbidity OT - Cross-sectional study OT - Fatalism OT - Latin America OT - Mental health COIS- Declarations. Ethics approval: This study was approved by the Research Bioethics Committee of Universidad Privada Antenor Orrego (Resolution No. 0237-2020-UPAO) and was conducted in accordance with the principles of the Declaration of Helsinki. Informed consent: Informed consent was obtained electronically from all individual participants included in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:30 PMCR- 2026/07/24 CRDT- 2026/10/22 21:38 PHST- 2026/03/23 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/22 23:30 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 21:38 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.1186/s12879-026-14042-7 [pii] AID - 14042 [pii] AID - 10.1186/s12879-026-14042-7 [doi] PST - epublish SO - BMC Infect Dis. 2026 Jul 24;26(1):1852. doi: 10.1186/s12879-026-14042-7. PMID- 42906735 OWN - NLM STAT- Publisher LR - 20261023 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 219 DP - 2026 Oct 21 TI - Revisiting the obesogenic potential of legacy pollutants: Epidemiological, toxicogenomic, and benchmark dose-based evidence. PG - 116468 LID - S0278-6915(26)00543-0 [pii] LID - 10.1016/j.fct.2026.116468 [doi] AB - Legacy pollutants remain detectable in human populations despite decades of regulatory control, yet whether they continue to pose biologically relevant health risks under contemporary exposure scenarios remains unclear. Here we integrated epidemiology, toxicogenomics, and benchmark dose (BMD)-based risk assessment to re-evaluate the obesogenic potential of legacy pollutants in 665 adolescents. Among 97 quantified environmental chemicals in serum samples, hexachlorobenzene (HCB) and pentachlorophenol (PCP) were consistently identified as the principal contributors to overweight/obesity by generalized linear and weighted quantile sum models. Toxicogenomics, molecular docking, and adverse outcome pathway analyses indicate that both chemicals converge on endocrine and metabolic disruption and oxidative stress through key regulators including PPARgamma, INS, ESR1, TNF, and TP53. In vitro validation confirmed dose-dependent perturbations of obesity-related biomarkers, yielding biologically relevant points of departure through BMD modeling. Margin-of-exposure (MOE) analysis integrating these thresholds with human biomonitoring data revealed generally moderate-to-low risk for HCB, whereas approximately 4% of participants exhibited high-risk PCP exposure. These findings demonstrate that certain legacy pollutants remain biologically active and risk-relevant despite long-term regulation and highlight the value of integrating epidemiological evidence with mechanistic and quantitative toxicology for prioritizing chemicals of public health concern in the exposome era. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Li, Ming AU - Li M AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Cao, Yan AU - Cao Y AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Shi, Shiyu AU - Shi S AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Wu, Fan AU - Wu F AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Xie, Chang AU - Xie C AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Song, Lulu AU - Song L AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. FAU - Wang, Youjie AU - Wang Y AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. FAU - Tao, Yun AU - Tao Y AD - Department of Obstetrics, Zhongnan Hospital of Wuhan University, 169, East Lake Road, Wuchang District, Wuhan, Hubei, 430071, China. Electronic address: taoyun@whu.edu.cn. FAU - Mei, Surong AU - Mei S AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. Electronic address: surongmei@hust.edu.cn. LA - eng PT - Journal Article DEP - 20261021 PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 SB - IM OTO - NOTNLM OT - Benchmark dose-based risk assessment OT - Environmental obesogens OT - Human biomonitoring OT - In silico approach OT - Legacy pollutants COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:29 CRDT- 2026/10/22 19:55 PHST- 2026/08/21 00:00 [received] PHST- 2026/10/20 00:00 [revised] PHST- 2026/10/21 00:00 [accepted] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 23:29 [medline] PHST- 2026/10/22 19:55 [entrez] AID - S0278-6915(26)00543-0 [pii] AID - 10.1016/j.fct.2026.116468 [doi] PST - aheadofprint SO - Food Chem Toxicol. 2026 Oct 21;219:116468. doi: 10.1016/j.fct.2026.116468. PMID- 42906500 OWN - NLM STAT- Publisher LR - 20261022 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 270 DP - 2026 Oct 21 TI - Move or sit: Preschoolers' in-kindergarten physical activity and its association with fundamental motor skills using AI-assisted movement assessment. PG - 107976 LID - S0001-6918(26)01777-4 [pii] LID - 10.1016/j.actpsy.2026.107976 [doi] AB - This observational study examined physical activity (PA) across three kindergarten contexts and its association with fundamental motor skills (FMS), with a proprietary AI-assisted video/action-analysis tool used as a supplementary assessment aid. Fifty-seven children (61.11 +/- 12.73 months; range 45-81 months) from one kindergarten in Chengdu, China, were observed during morning exercise, organized physical education (PE), and free play using the Observational System for Recording Physical Activity in Children-Preschool Version (OSRAC-P); FMS were assessed with the standardized Fundamental Movement Skills Development Test for Children Aged 3-10 Years. The AI component was the proprietary "Xiaoneng Classmate" action-analysis platform developed by Chengdu Tixiaoneng Education Technology Co., Ltd.; manufacturer materials document AI-assisted action/video analysis and digital testing/data functions but do not disclose a public model architecture or study-specific validation metrics. Mean activity level was highest during morning exercise (3.29 +/- 0.09), followed by free play (2.94 +/- 0.40), and lowest during organized PE (2.46 +/- 0.26). Organized PE had the highest sedentary frequency (46.58% +/- 12.69%), whereas free play had the highest MVPA frequency (33.92% +/- 13.03%). To address multicollinearity in the original high-dimensional regression, parsimonious individual-level models adjusted for age, sex, and BMI and included MVPA during organized PE and free play. Organized-PE MVPA was positively associated with locomotor skill score (B = 0.471 per percentage point, HC3 SE = 0.141, beta = 0.407, 95% CI [0.187, 0.754], p = .002) and showed a weaker association with total FMS (B = 0.484, HC3 SE = 0.235, beta = 0.234, 95% CI [0.011, 0.957], p = .045); no PA predictor was significant for object-control or stability scores. Morning-exercise MVPA was not entered in the individual-level regression because it had no within-class variability. These findings are context-specific associations and do not establish causal direction. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Xu, Dongmiao AU - Xu D AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: 2024227025001@stu.scu.edu.cn. FAU - Yang, Shunxiang AU - Yang S AD - Primary School Affillated to the Experimental High School of UESTC, Chengdu, 611730, China. Electronic address: shunxiangyang@163.com. FAU - Liu, Liu AU - Liu L AD - School of Physical Education, Sichuan University, Chengdu, 610065, China; School of Modern Service in Mianyang City College, Mianyang, 621000, China. Electronic address: liu_liu@scu.edu.cn. FAU - Gou, Jingpu AU - Gou J AD - College of Sports Training in Chengdu Sport University, Chengdu, 610041, China. Electronic address: guojingpu@sina.com. FAU - Zeng, Hongguang AU - Zeng H AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: 570959086@qq.com. FAU - Liu, Liling AU - Liu L AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: lilingliu0209@163.com. FAU - Zhu, Liangyu AU - Zhu L AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: zly0621@scu.edu.cn. LA - eng PT - Journal Article DEP - 20261021 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM OTO - NOTNLM OT - AI-assisted movement assessment OT - Fundamental motor skills OT - OSRAC-P OT - Physical activity OT - Preschool children COIS- Declaration of competing interest The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:29 CRDT- 2026/10/22 19:40 PHST- 2026/07/09 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/10/07 00:00 [accepted] PHST- 2026/10/22 23:29 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 19:40 [entrez] AID - S0001-6918(26)01777-4 [pii] AID - 10.1016/j.actpsy.2026.107976 [doi] PST - aheadofprint SO - Acta Psychol (Amst). 2026 Oct 21;270:107976. doi: 10.1016/j.actpsy.2026.107976. PMID- 42905624 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261024 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Investigating the role of mental health and lifestyle behaviours in the risk of adolescent suicidal behaviours through machine learning. PG - e0358758 LID - 10.1371/journal.pone.0358758 [doi] LID - e0358758 AB - BACKGROUND: Suicidal behaviors among adolescents are a serious global public health concern and are closely linked to both mental health and everyday lifestyle behaviors. Suicidal ideation, planning, and attempts lie along a spectrum of increasing severity. However, how psychological distress and health-related behaviors interact to influence suicide risk is complex and not yet fully understood. This study aimed to identify key mental health and lifestyle factors associated with different stages of adolescent suicidal behaviors using interpretable machine learning methods. METHODS: Data were obtained from the 2021 Youth Risk Behavior Surveillance System (YRBS), a nationally representative survey of U.S. high school students. After data cleaning and multiple imputation, 16,946 adolescents aged 14-18 years were included in the analysis. Extreme Gradient Boosting (XGBoost) models were developed to predict suicidal ideation, suicide planning, and suicide attempts. Model performance was assessed using the area under the receiver operating characteristic curve (AUC) and related metrics. Feature importance was examined using gain-based measures, while SHapley Additive exPlanations (SHAP) and partial dependence plots were used to explore the direction, strength, and nonlinear effects of key predictors. RESULTS: All three XGBoost models showed satisfactory predictive performance. Mental health factors, particularly persistent feelings of sadness and self-rated mental health, were the strongest predictors across all stages of suicidal behaviors. Lifestyle behaviors, including sleep duration, physical activity, diet, screen time, and substance use, also contributed meaningfully to risk prediction, although their relative importance differed by outcome. SHAP analyses indicated that greater sadness and poorer mental health were strongly associated with higher suicide risk, whereas adequate sleep and higher levels of physical activity were associated with lower predicted risk. Substance use, including alcohol, cigarette, and marijuana use, played an important role in predicting suicide attempts than suicidal ideation or planning. Partial dependence analyses showed nonlinear and threshold effects, especially for sadness, mental health status, and sleep duration. CONCLUSION: Mental health factors, especially persistent sadness and overall psychological well-being, were among the most prominent factors associated with suicidal behaviors among adolescents, while lifestyle behaviors showed important and stage-specific associations. Interpretable machine learning approaches help identify complex and nonlinear patterns associated with adolescent suicide risk and offer valuable insights to guide targeted, evidence-based prevention efforts. CI - Copyright: (c) 2026 Ding, Lei. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ding, Yanmei AU - Ding Y AD - Shanghai Civil Aviation College, Shanghai, China. FAU - Lei, Yanzhao AU - Lei Y AUID- ORCID: 0009-0002-4442-8327 AD - Shanghai SIPO Polytechnic, Shanghai, China. LA - eng PT - Journal Article DEP - 20261021 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - *Mental Health MH - *Life Style MH - Female MH - *Machine Learning MH - Male MH - *Suicide, Attempted/psychology/statistics & numerical data MH - *Adolescent Behavior/psychology MH - Boosting Machine Learning Algorithms MH - *Suicidal Ideation MH - Risk Factors MH - Predictive Learning Models MH - Risk-Taking PMC - PMC13686503 COIS- NO authors have competing interests. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:30 PMCR- 2026/10/21 CRDT- 2026/10/22 18:24 PHST- 2026/01/23 00:00 [received] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/10/22 23:30 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 18:24 [entrez] PHST- 2026/10/21 00:00 [pmc-release] AID - PONE-D-26-03940 [pii] AID - 10.1371/journal.pone.0358758 [doi] PST - epublish SO - PLoS One. 2026 Oct 21;21(10):e0358758. doi: 10.1371/journal.pone.0358758. eCollection 2026. PMID- 42903657 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261023 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Retinoic acid signaling in growth plate development: receptor-specific effects, antagonist evidence, and pediatric translational considerations. PG - 1962290 LID - 10.3389/fendo.2026.1962290 [doi] LID - 1962290 AB - The growth plate is a spatially organized cartilage structure that drives longitudinal bone growth and is particularly vulnerable to nutritional imbalance, systemic disease, trauma, and drug exposure during childhood. Retinoic acid (RA), the bioactive metabolite of vitamin A, regulates transcription through retinoic acid receptors (RARalpha, RARbeta, and RARgamma). Its skeletal effects depend on concentration, developmental timing, tissue context, and receptor subtype. Physiologic RA homeostasis contributes to orderly chondrocyte maturation, whereas excessive or spatially inappropriate signaling can suppress proliferation, alter hypertrophic differentiation and extracellular matrix, and promote premature growth plate senescence or closure in experimental models. This narrative review integrates evidence on RA metabolism, RAR-dependent chondrocyte fate, and experimental RAR antagonists. Model-dependent antagonist effects include concurrent prevention of hedgehog inhibitor-associated closure and early post-injury attenuation of growth inhibition in juvenile mice; prevention during induction is not reversal of established physeal damage. Human zone-specific receptor biology remains insufficiently resolved, and apparently conflicting findings reflect differences in receptor pharmacology, tissue, developmental stage, timing, dose, and endpoint. Pediatric experience with systemic retinoids, including isotretinoin and the RARgamma agonist palovarotene, underscores the developmental hazards of pathway modulation. Future studies should prioritize validated human growth plate models, receptor-subtype pharmacology, and longitudinal skeletal monitoring. RAR antagonism remains a preclinical, hypothesis-generating strategy requiring rigorous dose-window and long-term safety evaluation before pediatric clinical investigation. CI - Copyright (c) 2026 Xing, Fan, Wang, Ma, Xuan and Zhang. FAU - Xing, Yutong AU - Xing Y AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Fan, Ruiying AU - Fan R AD - Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China. FAU - Wang, Kaixi AU - Wang K AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Ma, Xinyu AU - Ma X AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Xuan, Fan AU - Xuan F AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Zhang, Huifeng AU - Zhang H AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. LA - eng PT - Journal Article PT - Review DEP - 20261006 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Receptors, Retinoic Acid) RN - 5688UTC01R (Tretinoin) RN - 0 (Retinoic Acid Receptor gamma) SB - IM MH - Humans MH - *Growth Plate/metabolism/growth & development/drug effects MH - Animals MH - *Receptors, Retinoic Acid/antagonists & inhibitors/metabolism MH - *Signal Transduction MH - *Tretinoin/metabolism MH - *Bone Development MH - Chondrocytes/metabolism MH - Translational Research, Biomedical MH - Child MH - Retinoic Acid Receptor gamma PMC - PMC13681268 OTO - NOTNLM OT - RAR antagonist OT - chondrocyte OT - endochondral ossification OT - epiphyseal closure OT - growth plate OT - pediatric growth OT - retinoic acid OT - retinoic acid receptor COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/22 17:33 MHDA- 2026/10/22 17:34 PMCR- 2026/10/06 CRDT- 2026/10/22 13:55 PHST- 2026/08/08 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/22 17:34 [medline] PHST- 2026/10/22 17:33 [pubmed] PHST- 2026/10/22 13:55 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - 10.3389/fendo.2026.1962290 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Oct 6;17:1962290. doi: 10.3389/fendo.2026.1962290. eCollection 2026. PMID- 42903563 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261022 LR - 20261023 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Feeding practices during high-flow nasal cannula: current evidence and clinical implications for respiratory care. PG - 1948830 LID - 10.3389/fnut.2026.1948830 [doi] LID - 1948830 AB - High-flow nasal cannula (HFNC) therapy is increasingly used as a noninvasive respiratory support modality across acute and critical care settings. Although nutritional management is integral to the care of patients with respiratory failure, established guidelines for feeding patients receiving HFNC are lacking, and clinical decisions vary widely, reflecting persistent uncertainty about HFNC's effects on swallowing function, airway protection, and aspiration risk. This narrative review found that HFNC may alter swallowing biomechanics, particularly at flow rates >40 L/min, potentially increasing the risk of choking and aspiration. Evidence on aspiration risk is heterogeneous, deriving largely from healthy volunteers and pediatric bronchiolitis cohorts. Adult evidence is limited to retrospective studies; the largest found no increase in respiratory deterioration with enteral feeding. Most institutions lack formal feeding protocols, and practice is driven by individual clinician judgment. Areas of consensus include the safety of early enteral feeding in hemodynamically stable patients and the avoidance of routine prolonged withholding of nutrition based solely on HFNC use. Disagreement persists regarding routine swallowing assessment, optimal flow thresholds during feeding, and the prioritization of oral versus tube feeding. Safe feeding in patients receiving HFNC requires a multidisciplinary, individualized approach that balances respiratory support against nutritional adequacy. Prospective multicenter studies are needed to define safe flow thresholds, validate bedside assessment tools, and establish standardized feeding guidelines, particularly in adult and critically ill populations. CI - Copyright (c) 2026 Alqahtani, Alkhelb, Alamri, Alqahtani, Alshehri, Ghazwani, Almarkhan, Alqahtani, Alenezi, Aldhahir, Siraj, Alqarni, Alwafi, Almarkhan, Salem, Alrabeeah, Alanazi, Alamoudi and Alghamdi. FAU - Alqahtani, Jaber S AU - Alqahtani JS AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. AD - Research and Innovation Institute, Ministry of Defense Health Services, Riyadh, Saudi Arabia. FAU - Alkhelb, Jood AU - Alkhelb J AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alamri, Alaa AU - Alamri A AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alqahtani, Leen AU - Alqahtani L AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alshehri, Razan AU - Alshehri R AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Ghazwani, Abdullah A AU - Ghazwani AA AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Almarkhan, Hussam M AU - Almarkhan HM AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alqahtani, Ahmed S AU - Alqahtani AS AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alenezi, Meshal H AU - Alenezi MH AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Aldhahir, Abdulelah M AU - Aldhahir AM AD - Respiratory Therapy Program, Department of Nursing, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Siraj, Rayan A AU - Siraj RA AD - Department of Respiratory Therapy, College of Applied Medical Sciences, King Faisal University, Al-Ahsa, Saudi Arabia. FAU - Alqarni, Abdullah A AU - Alqarni AA AD - Department of Respiratory Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Alwafi, Hassan AU - Alwafi H AD - Faculty of Medicine, Umm Al Qura University, Mecca, Saudi Arabia. FAU - Almarkhan, Sulaiman M AU - Almarkhan SM AD - King Fahad Military Medical Complex, Ministry of Defense Health Services, Dhahran, Saudi Arabia. FAU - Salem, Fahad A AU - Salem FA AD - King Fahad Military Medical Complex, Ministry of Defense Health Services, Dhahran, Saudi Arabia. FAU - Alrabeeah, Saad AU - Alrabeeah S AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alanazi, Faisal R AU - Alanazi FR AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alamoudi, Asma O AU - Alamoudi AO AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alghamdi, Saeed M AU - Alghamdi SM AD - Clinical Technology Department, Respiratory Care Program, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia. LA - eng PT - Journal Article PT - Review DEP - 20261006 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13681048 OTO - NOTNLM OT - aspiration OT - deglutition disorders OT - enteral nutrition OT - feeding OT - high-flow nasal cannula OT - oxygen inhalation therapy OT - respiratory failure OT - respiratory insufficiency COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/22 17:33 MHDA- 2026/10/22 17:34 PMCR- 2026/10/06 CRDT- 2026/10/22 13:31 PHST- 2026/07/26 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/22 17:34 [medline] PHST- 2026/10/22 17:33 [pubmed] PHST- 2026/10/22 13:31 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - 10.3389/fnut.2026.1948830 [doi] PST - epublish SO - Front Nutr. 2026 Oct 6;13:1948830. doi: 10.3389/fnut.2026.1948830. eCollection 2026. PMID- 42903521 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261022 LR - 20261023 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Gut microbiota dysbiosis in pediatric acute lymphoblastic leukemia: clinical consequences, mechanistic insights, and microbiota-targeted interventions. PG - 1928304 LID - 10.3389/fped.2026.1928304 [doi] LID - 1928304 AB - Gut microbiota dysbiosis has emerged as a key feature in pediatric acute lymphoblastic leukemia (ALL), driven by chemotherapy, antibiotic exposure, and treatment-related nutritional impairment. Increasing evidence indicates that disruption of microbial diversity and depletion of short-chain fatty acid-producing bacteria are closely associated with infectious complications, gastrointestinal toxicity, and potentially reduced treatment efficacy. This review synthesizes current evidence on the interplay between gut microbiota and pediatric ALL across four dimensions: clinical outcomes, treatment-related toxicity, pharmacological interactions, and prognosis. We further summarize how leukemia therapy reshapes microbial ecosystems through cytotoxic agents, antimicrobial exposure, and dietary alterations. In addition, we discuss microbiota-centered therapeutic strategies, including probiotics, prebiotics, synbiotics, postbiotics, dietary interventions, and fecal microbiota transplantation. While promising, these approaches require careful validation in pediatric oncology due to safety considerations and limited clinical trial data. Finally, we highlight methodological advances such as multi-omics integration and machine learning approaches, which may enable microbiome-based risk stratification and precision supportive care in the future. Overall, gut microbiota represents a potential modifiable factor influencing clinical outcomes in pediatric ALL. CI - (c) 2026 Chen, Li, Xing, Liu and Yang. FAU - Chen, Ke AU - Chen K AD - Department of Clinical Nutrition, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Li, Qingqing AU - Li Q AD - Department of Clinical Nutrition, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Xing, Yun AU - Xing Y AD - School of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China. FAU - Liu, Changqi AU - Liu C AD - School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, United States. FAU - Yang, Fei AU - Yang F AD - Department of Virtual Reality Technology, College of Digital Technology and Design, Chongqing Polytechnic University of Electronic Technology, Chongqing, China. LA - eng PT - Journal Article PT - Review DEP - 20261006 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13680964 OTO - NOTNLM OT - child OT - dysbiosis OT - gastrointestinal microbiome OT - leukemia OT - probiotics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/22 17:33 MHDA- 2026/10/22 17:34 PMCR- 2026/10/06 CRDT- 2026/10/22 13:22 PHST- 2026/07/04 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/22 17:34 [medline] PHST- 2026/10/22 17:33 [pubmed] PHST- 2026/10/22 13:22 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - 10.3389/fped.2026.1928304 [doi] PST - epublish SO - Front Pediatr. 2026 Oct 6;14:1928304. doi: 10.3389/fped.2026.1928304. eCollection 2026. PMID- 42903273 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261023 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Lion Hearts: applying implementation mapping to plan the delivery of a family-based physical activity intervention in community CrossFit affiliates. PG - 1970725 LID - 10.3389/fpubh.2026.1970725 [doi] LID - 1970725 AB - BACKGROUND: Community-based physical activity interventions face challenges in adoption, implementation, and sustainability. Lion Hearts is a family-based physical activity intervention designed to promote cardiovascular health among mothers and children aged 3-6 years. This study applied Implementation Mapping during intervention development to identify implementation determinants and develop stakeholder-informed strategies for subsequent pilot testing. METHODS: The five iterative tasks of Implementation Mapping were applied through a co-design process with seven CrossFit affiliate owner-coaches: (1) conducting an implementation needs and assets assessment and identifying adopters and implementers; (2) specifying implementation outcomes, performance objectives, determinants, and change objectives; (3) selecting theoretical change methods and implementation strategies; (4) producing implementation protocols and materials; and (5) developing a prospective implementation-evaluation plan. Two 60-min co-design sessions were conducted approximately eight weeks apart. The first elicited barriers and facilitators to adoption and delivery within affiliate settings. Audio recordings were transcribed verbatim, and three researchers reviewed and coded both transcripts using structured matrices, supplemented by facilitator notes. Findings were synthesized using rapid qualitative analysis and integrated with behavioral theory and implementation science frameworks to identify implementation determinants and develop implementation strategies and materials. This study applied the five tasks of Implementation Mapping to identify implementation determinants and develop stakeholder-informed strategies, delivery supports, and a prospective evaluation plan for subsequent pilot testing. RESULTS: Stakeholders identified implementation determinants related to coach knowledge and self-efficacy, participant engagement and competing demands, class structure and flow, scheduling, staffing, equipment availability, and compatibility with affiliate workflows. These findings informed implementation strategies and delivery supports targeting affiliate owners and coaches, including coach training resources, structured session templates, class-flow guidance, and fidelity-monitoring tools. Performance objectives and an implementation logic model were developed to specify hypothesized pathways linking determinants and strategies to prospective implementation outcomes. An evaluation plan was developed to assess reach, adoption, feasibility, acceptability, fidelity, and maintenance during subsequent pilot implementation. CONCLUSION: Implementation Mapping and stakeholder co-design produced a theory-informed, contextually responsive implementation package for Lion Hearts. Although implementation outcomes have not yet been evaluated, the resulting strategies, materials, and prospective evaluation plan are positioned for testing and refinement in community fitness settings. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT07147387. CI - Copyright (c) 2026 Watkins, Goss, Mehls, Marshall, Dlugonski and Downs. FAU - Watkins, Janette AU - Watkins J AD - Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States. FAU - Goss, Janelle AU - Goss J AD - Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States. FAU - Mehls, Kelton AU - Mehls K AD - Department of Health and Human Development, University of Pittsburgh, Pittsburgh, PA, United States. FAU - Marshall, Ali AU - Marshall A AD - Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States. FAU - Dlugonski, Deirdre AU - Dlugonski D AD - Department of Health & Clinical Sciences, College of Health Sciences, University of Kentucky, Lexington, KY, United States. FAU - Downs, Danielle Symons AU - Downs DS AD - Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States. AD - Department of Obstetrics and Gynecology, College of Medicine, The Pennsylvania State University, University Park, PA, United States. LA - eng SI - ClinicalTrials.gov/NCT07147387 PT - Journal Article DEP - 20261006 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Exercise MH - Female MH - *Health Promotion/methods/organization & administration MH - Child MH - Child, Preschool MH - Prospective Studies MH - Program Evaluation MH - *Family MH - Mothers MH - Pilot Projects MH - Male PMC - PMC13680431 OTO - NOTNLM OT - community fitness OT - family-based intervention OT - implementation mapping OT - implementation strategies OT - maternal health OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/22 17:33 MHDA- 2026/10/22 17:34 PMCR- 2026/10/06 CRDT- 2026/10/22 11:51 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/15 00:00 [revised] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/22 17:34 [medline] PHST- 2026/10/22 17:33 [pubmed] PHST- 2026/10/22 11:51 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1970725 [doi] PST - epublish SO - Front Public Health. 2026 Oct 6;14:1970725. doi: 10.3389/fpubh.2026.1970725. eCollection 2026. PMID- 42902702 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261023 IS - 2083-8441 (Electronic) IS - 2081-237X (Print) IS - 2083-8441 (Linking) VI - 32 IP - 3 DP - 2026 TI - Metabolic outcomes and insulin therapy modifications during Ramadan fasting in children with type 1 diabetes mellitus in low-resource settings. PG - 187-192 LID - 58344 [pii] LID - 10.5114/pedm.2026.163207 [doi] AB - INTRODUCTION: Young Muslims with type 1 diabetes mellitus (T1DM) face serious metabolic challenges during Ramadan fasting, particularly hypoglycemia, hyperglycemia, dehydration, and diabetic ketoacidosis (DKA) risks. Data from low-resource settings (LRS) with limited advanced monitoring tools are insufficient despite established guidelines. AIM OF THE STUDY: This study planned to evaluate metabolic outcomes and insulin modifications among children and adolescents with T1DM during Ramadan fasting in Surabaya, Indonesia. MATERIAL AND METHODS: Our cross-sectional study recruited 25 individuals with T1DM aged 7 to 18 years who fasted for at least two weeks during Ramadan 2025. Data were collected via questionnaires and glucose logbooks. Fasting blood glucose (FBG) was measured before, during, and after Ramadan. We also evaluated insulin total daily dose (TDD) and acute complication incidences. RESULTS: The respondents were predominantly female (80%) with a mean HbA1c of 10.22 +/-2.29%. During Ramadan, the mean TDD decreased from 0.84 +/-0.18 to 0.80 +/-0.19 U/kg/day, reflecting a 6.79% reduction in basal insulin. Mean FBG levels remained stable across the pre-, during-, and post-Ramadan periods (202.89, 193.44, and 206.90 mg/dl, respectively; p > 0.05). Clinical safety improved during fasting, with hypoglycemia rates decreasing from 28% to 12% and zero cases of DKA compared to a 16% pre-Ramadan history. CONCLUSIONS: Ramadan fasting is safe and feasible for young Muslims with T1DM in LRS when supported by structured pre-fasting education and individualized insulin modifications. These results emphasize that metabolic stability can be achieved through rigorous monitoring and clinical supervision even in the absence of advanced diabetes technologies. FAU - Puspitasari, Ajeng Dias AU - Puspitasari AD AD -

Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

. AD -

Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

. FAU - Perwitasari, Rayi Kurnia AU - Perwitasari RK AD -

Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

. AD -

Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

. FAU - Hisbiyah, Yuni AU - Hisbiyah Y AD -

Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

. AD -

Department of Child Health, Airlangga General Academic Hospital, Surabaya, Indonesia

. FAU - Abu-Libdeh, Abdulsalam I AU - Abu-Libdeh AI AD -

Division of Pediatric Endocrinology, Department of Pediatrics, Hadassah Hebrew University Medical Center, Jerusalem, Israel

. AD -

Department of Pediatrics and Genetics, Al-Makassed Hospital and Al-Quds Medical School, East Jerusalem, Palestine

. FAU - Rochmah, Nur AU - Rochmah N AD -

Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

. AD -

Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

. FAU - Faizi, Muhammad AU - Faizi M AD -

Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

. AD -

Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

. LA - eng PT - Journal Article TT - Wyniki metaboliczne i zmiany w insulinoterapii podczas postu ramadanowego u dzieci z cukrzyca typu 1 w warunkach ograniczonych zasobow. PL - Poland TA - Pediatr Endocrinol Diabetes Metab JT - Pediatric endocrinology, diabetes, and metabolism JID - 101518750 RN - 0 (Insulin) RN - 0 (Hypoglycemic Agents) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/drug therapy/metabolism/blood MH - Female MH - Child MH - Adolescent MH - Male MH - *Islam MH - *Insulin/administration & dosage/therapeutic use MH - Cross-Sectional Studies MH - *Fasting MH - *Hypoglycemic Agents/administration & dosage/therapeutic use MH - Indonesia/epidemiology MH - Blood Glucose/analysis MH - Hypoglycemia MH - Intermittent Fasting PMC - PMC13628191 OTO - NOTNLM OT - type 1 diabetes mellitus OT - Ramadan fasting OT - insulin modifications OT - low-resource settings. OT - metabolic outcomes COIS- None declared. EDAT- 2026/10/22 13:25 MHDA- 2026/10/22 13:26 PMCR- 2026/09/01 CRDT- 2026/10/22 08:31 PHST- 2026/10/22 13:26 [medline] PHST- 2026/10/22 13:25 [pubmed] PHST- 2026/10/22 08:31 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 58344 [pii] AID - 10.5114/pedm.2026.163207 [doi] PST - ppublish SO - Pediatr Endocrinol Diabetes Metab. 2026;32(3):187-192. doi: 10.5114/pedm.2026.163207. PMID- 42902610 OWN - NLM STAT- Publisher LR - 20261021 IS - 1308-5735 (Electronic) DP - 2026 Oct 21 TI - Diagnostic Performance of Urinary Clusterin for Early Detection of Diabetic Kidney Disease in Pediatric Type 1 Diabetes Mellitus: A Case-Control Analysis. LID - 10.4274/jcrpe.galenos.2026.2026-4-1 [doi] AB - BACKGROUND: Urinary Clusterin, a glycoprotein linked to oxidative stress and tubular injury, is being evaluated as a more sensitive biomarker for diabetic kidney disease (DKD). This study aims to assess the role of Clusterin in the early detection and prognostication of diabetic kidney disease in children with Type 1 Diabetes Mellitus (T1DM), addressing a critical gap in pediatric clinical data. METHODS: This case-control study at Beni-Suef University compared 50 children with T1DM (duration >/=5 years) to 40 healthy controls. Assessments included Body Mass Index (BMI), glycated hemoglobin (HbA1c), and lipid profiles. Urinary Clusterin was measured using Enzyme Linked Immunosorbent Assay (ELISA). A Receiver Operating Characteristic (ROC) curve analysis was employed to determine the diagnostic performance of urinary Clusterin in detecting diabetic nephropathy. RESULTS: Diabetic cases exhibited significantly higher levels of AST, cholesterol, triglycerides, and serum creatinine compared to the control group. The urinary profile revealed significantly elevated urinary creatinine, albumin, and albumin-to-creatinine ratios in cases, with urinary clusterin levels being significantly higher in children with diabetes (49.7 vs. 32.3 pg/mL, p<0.001) than in healthy controls. Within the case group, urinary clusterin significantly correlated with ALT, serum creatinine, and triglycerides, although no significant associations were found with age, BMI, or HbA1c. At a cutoff value of 37.6 pg/mL, urinary clusterin is a highly effective marker for early detection of diabetic nephropathy with an 80% sensitivity, and 90% specificity. CONCLUSION: Urinary clusterin is a potential non-invasive biomarker for early diabetic nephropathy in children with T1DM, outperforming traditional measures and offering a promising tool for earlier screening and improved clinical management. FAU - Hasan, Mennat Allah Taha AU - Hasan MAT AD - Department Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. FAU - Fahmey, Sameh S AU - Fahmey SS AD - Department Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. FAU - Ewas, Howaida Khairy AU - Ewas HK AUID- ORCID: 0000-0001-6362-7183 AD - Department Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. LA - eng PT - Journal Article DEP - 20261021 PL - Turkey TA - J Clin Res Pediatr Endocrinol JT - Journal of clinical research in pediatric endocrinology JID - 101519456 SB - IM OTO - NOTNLM OT - Apolipoprotein J OT - Diabetic Kidney Disease OT - Type 1 Diabetes Mellitus OT - Urinary Clusterin EDAT- 2026/10/21 11:28 MHDA- 2026/10/21 11:28 CRDT- 2026/10/21 09:27 PHST- 2026/10/21 11:28 [medline] PHST- 2026/10/21 11:28 [pubmed] PHST- 2026/10/21 09:27 [entrez] AID - 10.4274/jcrpe.galenos.2026.2026-4-1 [doi] PST - aheadofprint SO - J Clin Res Pediatr Endocrinol. 2026 Oct 21. doi: 10.4274/jcrpe.galenos.2026.2026-4-1. PMID- 42902300 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261023 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 23 TI - Retrospective cross-sectional study of clinical and laboratory profiles of paediatric tuberculosis at Ayder Comprehensive Specialized Hospital, Ethiopia (2018-2021). LID - 10.1186/s12887-026-07391-4 [doi] LID - 1029 AB - BACKGROUND: Pediatric Tuberculosis (TB) remains a diagnostic challenge owing to its paucibacillary nature and diverse clinical presentation. We aimed to characterise the clinical pattern, diagnostic yields, and predictors of disease forms among children managed at Ayder Comprehensive Specialized Hospital (ACSH), Mekelle, Ethiopia. OBJECTIVE: To describe the disease form distribution, clinical features, and laboratory profiles of pediatric tuberculosis at a tertiary Ethiopian hospital, and to identify independent predictors of extrapulmonary and disseminated disease using multivariable logistic regression. METHODS: We conducted an institution-based, retrospective analytical cross-sectional study of 123 children (< 18) diagnosed with TB at ACSH between May 2018 and April 2021. From 180 screened charts, we excluded 57 cases (prior treatment n = 27, incomplete records n = 20, insufficient evidence n = 10). Using validated data extraction checklist, we analysed sociodemographics, clinical presentation, nutritional status, comorbidities, laboratory results (GeneXpert, ESR, haemoglobin), and TB disease forms via SPSS version 23, applying bivariable and multivariable logistic regression. RESULTS: The mean age was 8.8 +/- 5.3 years; adolescents (11-17 years) comprised 42.3% (n = 52). Females were slightly predominant (52%). Common presenting symptoms included fever (78%), weight loss (71.5%), and cough (55.5%). Severe acute malnutrition (SAM) affected 37.7% (n = 40/106), with the highest burden in children aged < 5 years (45.7%). Anaemia was prevalent in 62.7% (n = 74/118); ESR was elevated in 84% (n = 89/106). Extrapulmonary TB (EPTB) was the most common form (43.9%; 95% CI 35.2-52.9). GeneXpert positivity was 31.3%. Younger age was significantly associated with EPTB (p < 0.001); children aged 0-4 years had over 3.5 times higher odds of EPTB compared with adolescents (AOR 3.57; 95% CI 1.28-10.00; p = 0.015). CONCLUSION: Paediatric TB in this referral setting is characterised by high rates of extrapulmonary and disseminated disease, severe malnutrition, and low bacteriological confirmation. Younger age was independently associated with disease dissemination, a finding consistent with the immunological characteristics of early childhood. Early, age-stratified screening and adoption of more sensitive diagnostic tools are urgently needed in similar high-burden settings. CI - (c) 2026. The Author(s). FAU - Girmay, Tekae Gebru AU - Girmay TG AD - Department of Pediatrics and Child health, School of Medicine, College of Medicine and health science, Mekelle University, Mekelle, Ethiopia. FAU - Gossaye, Tariku Yigremachew AU - Gossaye TY AUID- ORCID: 0009-0001-8137-1908 AD - Department of Pediatrics and Child health, College of Medicine and Health Science, Mizan Tepi University, Mizan Aman, Ethiopia. Tarikuyigremachew@gmail.com. FAU - Gebrihiet, Haftu Hailu AU - Gebrihiet HH AD - Department of Pediatrics and Child health, College of Medicine and Health science, Mekelle University, Mekelle, Ethiopia. FAU - Tsegay, Niguse AU - Tsegay N AD - Department of Pediatrics and Child health, College of Medicine and Health science, Mekelle University, Mekelle, Ethiopia. LA - eng PT - Journal Article DEP - 20260723 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - Ethiopia/epidemiology MH - Cross-Sectional Studies MH - Child MH - Male MH - Retrospective Studies MH - Adolescent MH - Tuberculosis, Extrapulmonary MH - *Tuberculosis/diagnosis/epidemiology MH - Child, Preschool MH - Infant PMC - PMC13685323 OTO - NOTNLM OT - Clinical profile OT - Diagnostic challenges OT - Ethiopia OT - Extrapulmonary TB OT - Paediatric tuberculosis COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance the declaration of Helsinki. Ethical approval was obtained from Institutional Review Board (IRB) of the College of Health Sciences of Mekelle University (Reference No: MU-IRB/1864/21). Permission from Ayder Comprehensive Specialized Hospital clinical director offices, support letter from chief clinical director obtained before the commencement of the study. Because this was retrospective chart review involving minimal risk to the participants, the requirement for informed consent from the parents or legal guardian of minors was formally waived by Mekelle University IRB. All patients' data were handled with strict confidentiality and were anonymized prior to Analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/21 05:32 MHDA- 2026/10/21 05:33 PMCR- 2026/07/23 CRDT- 2026/10/21 00:43 PHST- 2026/03/16 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/10/21 05:33 [medline] PHST- 2026/10/21 05:32 [pubmed] PHST- 2026/10/21 00:43 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1186/s12887-026-07391-4 [pii] AID - 7391 [pii] AID - 10.1186/s12887-026-07391-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 23;26(1):1029. doi: 10.1186/s12887-026-07391-4. PMID- 42901802 OWN - NLM STAT- Publisher LR - 20261020 IS - 1532-5040 (Electronic) IS - 0959-3985 (Linking) DP - 2026 Oct 20 TI - Cardiopulmonary exercise testing in children with cerebral palsy: Feasibility and the relationship between aerobic capacity and gross motor function: A pilot study. PG - 1-10 LID - 10.1080/09593985.2026.2751571 [doi] AB - INTRODUCTION: Children with cerebral palsy (CP) may exhibit reduced aerobic capacity. While the cardiopulmonary exercise test (CPET) is the gold standard for determining aerobic capacity, motor disorders and accompanying disturbances make its application challenging. The 6-minute walk test (6-MWT) may offer a practical alternative. OBJECTIVE: To evaluate the feasibility of CPET, explore its relationship with the 6-MWT, and investigate the association between aerobic capacity and gross motor function in children with CP. METHODS: Children aged 6-13 years with unilateral/bilateral spastic CP classified as Gross Motor Function Classification System Level II, who could follow instructions and walk on a treadmill without physical assistance, were included. The Gross Motor Function Measure-88 (GMFM-88), 6-MWT, and treadmill-based CPET were performed. CPET feasibility was evaluated by maximal exertion and termination reasons. RESULTS: Eight participants (four males, four females; four spastic unilateral, four spastic bilateral) with a median age of 8.5 years were enrolled. The median (minimum-maximum) peak oxygen consumption (VO(2peak)), respiratory exchange ratio (RER), and maximum heart rate (HR(max)) in CPET were 21 (17.1-30.6) mL/kg/min, 0.87 (0.81-1.00), and 145.5 (97-174) bpm, respectively. One participant achieved near-maximal exertion during CPET, while the others demonstrated submaximal effort. Reasons for CPET termination included lower limb fatigue (n = 5) and poor compliance (n = 3). The 6-minute walk distance (6MWD) was not significantly correlated with VO(2peak) (r = 0.000, p > .999). 6MWD was strongly correlated with the GMFM-88 total score (r = 0.790, p = .020). Moderate correlations, which were not statistically significant, were found between 6MWD and the GMFM-88 Dimensions D (r = 0.672, p = .068) and E (r = 0.695, p = .056). No significant correlations were observed between the GMFM-88 scores and VO(2peak), RER, or HR(max). CONCLUSION: Treadmill-based CPET demonstrated limitations in reaching maximal aerobic capacity in this pilot sample of children with CP. The 6-MWT may offer a practical approach for evaluating functional performance, given its association with gross motor function. FAU - Ozdemir Tekes, Sevgi Esra AU - Ozdemir Tekes SE AUID- ORCID: 0009-0006-9272-4840 AD - Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey. FAU - Turan, Burak Kamil AU - Turan BK AUID- ORCID: 0000-0002-4382-9463 AD - Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey. FAU - Kutlay, Sehim AU - Kutlay S AUID- ORCID: 0000-0002-6869-6070 AD - Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey. FAU - Sonel Tur, Birkan AU - Sonel Tur B AUID- ORCID: 0000-0002-0798-4554 AD - Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20261020 PL - England TA - Physiother Theory Pract JT - Physiotherapy theory and practice JID - 9015520 SB - IM OTO - NOTNLM OT - 6-minute walk test OT - cardiopulmonary exercise test OT - cerebral palsy OT - exercise tolerance OT - gross motor function EDAT- 2026/10/20 23:29 MHDA- 2026/10/20 23:29 CRDT- 2026/10/20 21:53 PHST- 2026/10/20 23:29 [medline] PHST- 2026/10/20 23:29 [pubmed] PHST- 2026/10/20 21:53 [entrez] AID - 10.1080/09593985.2026.2751571 [doi] PST - aheadofprint SO - Physiother Theory Pract. 2026 Oct 20:1-10. doi: 10.1080/09593985.2026.2751571. PMID- 42900350 OWN - NLM STAT- Publisher LR - 20261020 IS - 1933-7205 (Electronic) IS - 1933-7191 (Linking) DP - 2026 Oct 20 TI - Roles and Biological Effects of Polysaccharides in Polycystic Ovary Syndrome: A Narrative Review. LID - 10.1007/s43032-026-02232-2 [doi] AB - Polycystic ovary syndrome (PCOS) represents a prevalent and clinically significant reproductive-endocrine disorder among women of childbearing age. While dietary interventions, regular physical activity, and targeted lifestyle modifications have been validated to confer therapeutic benefits for PCOS management, polysaccharides key bioactive components of higher plants with extensive distribution throughout the plant and animal kingdoms exhibit distinct pleiotropic bioactivities, including anti-inflammatory, immunomodulatory, hypoglycemic, lipid-lowering, and anti-obesogenic properties. In the context of PCOS treatment, these natural macromolecules hold considerable promise for alleviating clinical manifestations, ameliorating insulin resistance and obesity, attenuating inflammatory responses, and restoring sex hormone homeostasis. Cumulative evidence from preclinical and clinical studies has demonstrated that polysaccharides can improve menstrual irregularities, reduce body weight, lower blood glucose and serum testosterone levels, and suppress aberrant inflammation. The present review systematically summarizes the multifaceted effects of diverse polysaccharide compounds on PCOS, aiming to provide insights into their potential as complementary therapeutic agents for this complex disorder. CI - (c) 2026. The Author(s), under exclusive licence to Society for Reproductive Investigation. FAU - Ding, Ning AU - Ding N AD - Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Sun, Chang AU - Sun C AD - Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Wang, Haotian AU - Wang H AD - Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Lv, Yingchun AU - Lv Y AD - Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Han, Yanhua AU - Han Y AD - The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Kuang, Hongying AU - Kuang H AUID- ORCID: 0009-0008-6885-7445 AD - The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. 949304685@qq.com. LA - eng GR - 82374509，82174422/National Natural Science Foundation of China/ GR - 2022CYCX0026/Longjiang Science and Technology Talent Spring Swan Support Program/ GR - LH2023H062/Natural Science Foundation of Heilongjiang Province/ GR - FCK-ZSYTW-08/China Special Research Fund for Obstetrics and Gynecology of Integrated Traditional Chinese and Western Medicine/ PT - Journal Article PT - Review DEP - 20261020 PL - United States TA - Reprod Sci JT - Reproductive sciences (Thousand Oaks, Calif.) JID - 101291249 SB - IM OTO - NOTNLM OT - Astragalus polysaccharides OT - Inulin OT - PCOS OT - Polysaccharides OT - Poria polysaccharides COIS- Declarations. Consent for Publication: Not applicable. Ethics Approval: Not applicable. Consent to Participate: Not applicable. Competing Interests: The authors declare no competing interests. EDAT- 2026/10/20 17:34 MHDA- 2026/10/20 17:34 CRDT- 2026/10/20 14:46 PHST- 2026/01/08 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/20 17:34 [medline] PHST- 2026/10/20 17:34 [pubmed] PHST- 2026/10/20 14:46 [entrez] AID - 10.1007/s43032-026-02232-2 [pii] AID - 10.1007/s43032-026-02232-2 [doi] PST - aheadofprint SO - Reprod Sci. 2026 Oct 20. doi: 10.1007/s43032-026-02232-2. PMID- 42899151 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261020 LR - 20261022 IS - 2590-1575 (Electronic) IS - 2590-1575 (Linking) VI - 39 DP - 2026 Oct TI - Goat and cow milk merits distinct nutritional and functional properties based on simulated gastrointestinal digestion of infant. PG - 104582 LID - 10.1016/j.fochx.2026.104582 [doi] LID - 104582 AB - The nutritional and functional properties of goat and cow milk in digestive tract of infant is unclear. Applying simulated infant gastrointestinal digestion method, this study aims to systematically compare digestibility, peptide profiling, and immunomodulatory role of goat and cow milk, and further characterize their role in regulating homeostasis of gut microbiota and metabolism. It's found that the degree of hydrolysis and number of detected peptides was higher in goat milk (GM), while the relative abundance of predicted allergic peptides was higher in cow milk (CM). In addition, the expression of IL-1beta and/or IL-6 in colonic organoids was elevated after GM or CM digesta intervention. Furthermore, GM and CM showed distinct effects on the composition of gut microbiota and metabolite profiles in an in vitro hindgut fermentation system using infant fecal inocula. The results provide basis for future applications of GM and CM in infant feeding, and further validation is required. CI - (c) 2026 The Authors. FAU - Chen, Jiaxin AU - Chen J AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. AD - College of Animal Science, Shanxi Agricultural University, Taigu 030800, China. FAU - Zhu, Ruikai AU - Zhu R AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Wu, Linjun AU - Wu L AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Kuang, Jian AU - Kuang J AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Bian, Xiangyu AU - Bian X AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Li, Xiaoqiong AU - Li X AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Wang, Weiwei AU - Wang W AD - College of Animal Science, Shanxi Agricultural University, Taigu 030800, China. FAU - Kang, Wenjie AU - Kang W AD - Yeeper (Qingdao) Sheep Dairy Co., LTD., Qingdao 266000, China. AD - Yeeper (Qingdao) Hypoallergenic Nutritional Research Institute, Qingdao 266000, China. FAU - Mu, Shanbo AU - Mu S AD - Yeeper (Qingdao) Sheep Dairy Co., LTD., Qingdao 266000, China. AD - Yeeper (Qingdao) Hypoallergenic Nutritional Research Institute, Qingdao 266000, China. FAU - Liu, Bryan Yanwen AU - Liu BY AD - Yeeper (Qingdao) Hypoallergenic Nutritional Research Institute, Qingdao 266000, China. AD - College of Biotechnology, East China University of Science and Technology, Shanghai 200237, China. AD - Key Laboratory of Microbial Physiology and Metabolism, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. FAU - Zhao, Ke AU - Zhao K AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Li, Jinjun AU - Li J AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. LA - eng PT - Journal Article DEP - 20261007 PL - Netherlands TA - Food Chem X JT - Food chemistry: X JID - 101751436 PMC - PMC13679301 OTO - NOTNLM OT - Cow milk OT - Goat milk OT - Gut microbiota OT - Infant OT - Metabolites OT - Peptides OT - Simulated gastrointestinal digestion COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/20 18:32 MHDA- 2026/10/20 18:33 PMCR- 2026/10/07 CRDT- 2026/10/20 12:52 PHST- 2026/04/19 00:00 [received] PHST- 2026/10/04 00:00 [revised] PHST- 2026/10/05 00:00 [accepted] PHST- 2026/10/20 18:33 [medline] PHST- 2026/10/20 18:32 [pubmed] PHST- 2026/10/20 12:52 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - S2590-1575(26)01103-X [pii] AID - 104582 [pii] AID - 10.1016/j.fochx.2026.104582 [doi] PST - epublish SO - Food Chem X. 2026 Oct 7;39:104582. doi: 10.1016/j.fochx.2026.104582. eCollection 2026 Oct. PMID- 42898497 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261020 LR - 20261022 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 20 DP - 2026 Dec TI - Content validation of the Eating Behavior and Appetite Questionnaire (EBAQ) in adolescents with obesity or overweight. PG - 100342 LID - 10.1016/j.obpill.2026.100342 [doi] LID - 100342 AB - BACKGROUND: Obesity in children and adolescents is a growing global concern. Changes in appetite and eating behaviors are clinically relevant outcomes for long-term management of obesity. The Eating Behavior and Appetite Questionnaire (EBAQ) was developed as existing patient-reported outcome measures do not comprehensively capture concepts important to individuals with obesity. Its content and psychometric validity have been demonstrated in adults; this study evaluated the content validity of the 17-item EBAQ in adolescents with obesity or overweight. METHODS: This cross-sectional qualitative study included US-based adolescents (12-17 years) with obesity or with overweight and >/=1 obesity-related complication. Cognitive interviews were conducted via telephone/teleconference using a semi-structured interview guide. Participants completed the EBAQ and provided feedback on its relevance, clarity, and comprehensiveness. Transcripts were coded using a coding framework. RESULTS: Fifteen adolescents (mean age, 14.7 years; mean body-mass index, 33.6 kg/m(2)) participated. Most (12/15, 80%) had not received obesity management medications (OMMs). All (15/15, 100%) understood the instructions and recall period, and 14/15 (93%) understood the response options. Each item was understood by >/= 80% of the participants (>/=12/15), except for Item 5 ('Appetite was controlled'). Item 5 was understood by all participants who had received OMMs (n = 3) but only a few of the treatment-naive participants (n = 4), suggesting more relevance for those on treatment. Each item was deemed relevant by >/= 54% of the participants (>/=7/15), except Item 17 ('Eating because stressed') which was considered relevant by 46% (6/13) of the participants. Overall, most participants (11/15, 73%) found the EBAQ well-structured, easy to understand and complete, and relevant. CONCLUSION: Findings support the conceptual relevance, clarity, and appropriateness of the 17-item EBAQ for adolescents with obesity or overweight. The EBAQ may be used to assess appetite and eating behavior outcomes in adolescents with obesity or overweight in clinical trials and observational studies. CI - (c) 2026 The Authors. FAU - Kanu, Chisom AU - Kanu C AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Clucas, Claudine AU - Clucas C AD - Patient-Centered Research, Evidera, PPD Clinical Research Business of Thermo Fisher Scientific, London, UK. FAU - Gibble, Theresa Hunter AU - Gibble TH AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Samuelson, Ashley AU - Samuelson A AD - Patient-Centered Research, Evidera, PPD Clinical Research Business of Thermo Fisher Scientific, Wilmington, NC, USA. FAU - Karn, Hayley AU - Karn H AD - Patient-Centered Research, Evidera, PPD Clinical Research Business of Thermo Fisher Scientific, London, UK. LA - eng PT - Journal Article DEP - 20261007 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13678099 OTO - NOTNLM OT - Adolescents OT - Appetite OT - Content validation OT - Eating behavior OT - Obesity OT - Patient-reported outcomes COIS- CK and THG are employees and shareholders of Eli Lilly and Company, which funded this study. CC, AS, and HK are current employees of Evidera, which was paid by Eli Lilly and Company to conduct this study. The Eating Behavior and Appetite Questionnaire (EBAQ) is copyrighted by Eli Lilly and Company and is free for use once permission is obtained. For permission to reproduce or use the EBAQ, contact copyright@lilly.com. EDAT- 2026/10/20 11:33 MHDA- 2026/10/20 11:34 PMCR- 2026/10/07 CRDT- 2026/10/20 08:46 PHST- 2026/07/23 00:00 [received] PHST- 2026/10/06 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/20 11:34 [medline] PHST- 2026/10/20 11:33 [pubmed] PHST- 2026/10/20 08:46 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - S2667-3681(26)00098-7 [pii] AID - 100342 [pii] AID - 10.1016/j.obpill.2026.100342 [doi] PST - epublish SO - Obes Pillars. 2026 Oct 7;20:100342. doi: 10.1016/j.obpill.2026.100342. eCollection 2026 Dec. PMID- 42898349 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261020 LR - 20261022 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Effects of dance-based physical activity on cognitive and psychological health across age groups: a systematic review. PG - 1838599 LID - 10.3389/fpsyg.2026.1838599 [doi] LID - 1838599 AB - BACKGROUND: Dance-based physical activity is a multimodal intervention integrating motor, cognitive, emotional, and social components, and has been increasingly recognized for its potential to enhance cognitive function and mental health. However, evidence regarding its effectiveness across different age groups remains fragmented. This systematic review aimed to synthesize current evidence on the effects of dance-based interventions on cognitive and psychological health across different age groups. METHODS: This systematic review was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD420261338912). Six electronic databases (PubMed, Web of Science Core Collection, Scopus, APA PsycINFO, Cochrane Central Register of Controlled Trials (CENTRAL), and SPORTDiscus) were systematically searched from database inception to 28 August 2026. Eligible studies included randomized controlled trials (RCTs) and controlled clinical trials (CCTs) that examined the effects of dance-based interventions on cognitive and/or psychological outcomes in participants of any age. Due to substantial heterogeneity in intervention types, outcome measures, and study designs, a narrative synthesis was performed. RESULTS: A total of 22 studies involving 1,645 participants aged 4 to 94 years were included. Favorable findings were reported for selected cognitive outcomes, including global cognition, memory, and attention, whereas findings for executive function were mixed. Some studies also reported favorable changes in depressive symptoms, anxiety, stress, emotional well-being, subjective well-being, and quality of life. However, these findings were not consistent across all studies or outcome measures, and differences in outcome measures and statistical reporting prevented reliable comparison of effect magnitude across studies. Several favorable findings were derived from studies judged to have a high, serious, or critical risk of bias. The evidence was predominantly derived from older adults, particularly those with cognitive impairment, whereas evidence involving children, adolescents, and younger or middle-aged adults remained limited and heterogeneous; therefore, definitive comparisons across age groups could not be made. CONCLUSION: Current evidence suggests that dance-based physical activity may have favorable effects on selected cognitive and psychological outcomes, with the evidence most extensively derived from older adults, particularly those with cognitive impairment. However, methodological heterogeneity, small sample sizes, study-level risk of bias, and limited long-term follow-up restrict the strength of these conclusions. Evidence involving children, adolescents, and younger or middle-aged adults remains insufficient for meaningful comparisons across age groups. Further high-quality trials are needed to determine optimal intervention parameters and clarify the mechanisms underlying the potential cognitive and psychological effects of dance-based physical activity. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420261338912, CRD420261338912. CI - Copyright (c) 2026 Fan and Liu. FAU - Fan, Yingying AU - Fan Y AD - School of Physical Education, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, China. FAU - Liu, Xutao AU - Liu X AD - School of Physical Education, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20261005 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13677549 OTO - NOTNLM OT - cognitive function OT - dance-based physical activity OT - lifespan OT - mental health OT - systematic review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/20 11:33 MHDA- 2026/10/20 11:34 PMCR- 2026/10/05 CRDT- 2026/10/20 07:24 PHST- 2026/03/25 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/20 11:34 [medline] PHST- 2026/10/20 11:33 [pubmed] PHST- 2026/10/20 07:24 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1838599 [doi] PST - epublish SO - Front Psychol. 2026 Oct 5;17:1838599. doi: 10.3389/fpsyg.2026.1838599. eCollection 2026. PMID- 42898029 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261028 IS - 1941-4935 (Electronic) IS - 1941-4927 (Print) IS - 1941-4935 (Linking) IP - 573 DP - 2026 Oct TI - Protein Consumption Among Youth and Adults: United States, August 2021-August 2023. LID - 10.15620/cdc/252474 [doi] AB - INTRODUCTION: National Health and Nutrition Examination Survey (NHANES) data were used to determine the mean percentage of total calories from protein and the mean percentage of total protein consumed from the top five food sources during August 2021-August 2023 and trends in the mean percentage of calories from protein consumed among U.S. youth and adults from 2013-2014 through August 2021-August 2023. METHODS: Participants age 2 and older with reliable dietary recall data from Day 1 were included. Pregnant and lactating women were excluded. The mean percentage of calories from protein and the population proportion of protein from each food group was calculated for youth and adults. Day 1 dietary interview weights were used to account for unequal probability of selection, noncoverage, nonresponse, and day of the week, and design variables were used to account for the clustered sampling design. Statistical significance was set at the p < 0.05 level. KEY FINDINGS: During August 2021-August 2023, youth consumed 13.9% of calories from protein, and consumption was higher among adolescents ages 12-19 (14.3%) than children ages 6-11 (13.3%). Adults consumed 15.5% of calories from protein with adults age 60 and older consuming less (15.1%) than younger adults (15.6% among those ages 20-39 and 15.7% among those ages 40-59). Among youth, the top five contributors of protein intake were sandwiches, poultry, milk, mixed grain dishes, and pizza. Among adults, the top five contributors of protein intake were sandwiches, poultry, mixed meat dishes, meat, and mixed grain dishes. Differences in the top contributors were observed by age. From 2013-2014 through August 2021-August 2023, the percentage of calories from protein consumed among youth decreased from 14.8% to 13.9% and from 16.1% to 15.5% among adults. CI - All material appearing in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated. FAU - Couch, Catharine A AU - Couch CA FAU - Ansai, Nicholas AU - Ansai N FAU - Noiman, Adi AU - Noiman A FAU - Ph D, Cynthia L Ogden AU - Ph D CLO LA - eng PT - Journal Article PL - United States TA - NCHS Data Brief JT - NCHS data brief JID - 101495625 RN - 0 (Dietary Proteins) SB - IM MH - Humans MH - United States MH - Female MH - *Dietary Proteins/administration & dosage MH - Nutrition Surveys MH - Adult MH - Adolescent MH - Energy Intake MH - Middle Aged MH - Child MH - Young Adult MH - Child, Preschool MH - Male MH - *Diet/statistics & numerical data MH - Aged PMC - PMC13697298 EDAT- 2026/10/20 05:30 MHDA- 2026/10/20 05:31 PMCR- 2026/10/26 CRDT- 2026/10/20 04:03 PHST- 2026/10/20 05:31 [medline] PHST- 2026/10/20 05:30 [pubmed] PHST- 2026/10/20 04:03 [entrez] PHST- 2026/10/26 00:00 [pmc-release] AID - 10.15620/cdc/252474 [doi] PST - ppublish SO - NCHS Data Brief. 2026 Oct;(573):10.15620/cdc/252474. doi: 10.15620/cdc/252474. PMID- 42897955 OWN - NLM STAT- Publisher LR - 20261020 IS - 1879-3479 (Electronic) IS - 0020-7292 (Linking) DP - 2026 Oct 19 TI - Association between atherogenic index of plasma at 11-20 weeks of gestation and gestational diabetes risk: A prospective cohort study in China. LID - 10.1002/ijgo.71417 [doi] AB - BACKGROUND: Recent studies have linked insulin resistance and the onset of type 2 diabetes mellitus to the atherogenic index of plasma (AIP). This integrated lipid marker reflects cardiovascular risk and atherogenic dyslipidemia. However, its relationship with gestational diabetes mellitus (GDM) is not completely understood. This study aimed to evaluate the association between AIP measured at 11-20 weeks of gestation and the subsequent risk of GDM and to identify the optimal AIP threshold for GDM prediction. METHODS: A total of 2068 women with singleton pregnancies were included in this prospective cohort study from the Tongji Maternal and Child Health Cohort. AIP was calculated from fasting triglycerides and high-density lipoprotein cholesterol (HDL-C) measurements obtained at 11-20 weeks of gestation, before GDM diagnosis by 75-g oral glucose tolerance test at 24-28 weeks of gestation. Subgroup analysis, restricted cubic spline models, and multivariable logistic regression were used to assess the relationship between GDM and AIP. The predictive performance of AIP alone and in combination with maternal age, pre-pregnancy body mass index (BMI), and low-density lipoprotein cholesterol (LDL-C) was compared via receiver operating characteristic curve analysis. RESULTS: Gestational diabetes mellitus was diagnosed in 252 participants (12.3%). Women in the highest AIP quartile demonstrated a substantially higher risk than those in the lowest quartile (adjusted odds ratio 2.56; 95% confidence interval (CI) 1.63-4.01; P < 0.001), and higher AIP levels were associated with a progressively higher risk of GDM. AIP and GDM risk were found to be significantly positively correlated (P for overall association <0.001), with no statistically significant evidence of nonlinearity (P for nonlinearity = 0.700), as assessed by restricted cubic spline analysis. Based on the maximum Youden index, an AIP value equal to 0.091 was determined to be the ideal cut-off for GDM prediction. A multivariable model incorporating AIP, pre-pregnancy BMI, maternal age, and LDL-C showed improved discriminative ability compared with AIP alone (area under the curve 0.69; 95% CI 0.66-0.73). CONCLUSION: Elevated AIP levels at 11-20 weeks of gestation were independently associated with an increased risk of GDM. Importantly, the inclusion of AIP alongside established maternal risk factors enhanced predictive accuracy. The findings of this study indicate that AIP might serve as a useful adjunctive biomarker in early antenatal screening to identify women at heightened risk for GDM. CI - (c) 2026 International Federation of Gynecology and Obstetrics. FAU - Kong, Man AU - Kong M AUID- ORCID: 0000-0002-9960-1556 AD - Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Zhong, Chunrong AU - Zhong C AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Gao, Qin AU - Gao Q AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Li, Qian AU - Li Q AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Xiong, Guoping AU - Xiong G AD - Department of Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Hao, Liping AU - Hao L AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yang, Xuefeng AU - Yang X AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Lu, Zhongxin AU - Lu Z AD - Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yang, Nianhong AU - Yang N AUID- ORCID: 0000-0003-1671-8028 AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. LA - eng GR - 2013FY114200/National Program on Basic Research Project of China/ PT - Journal Article DEP - 20261019 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 SB - IM OTO - NOTNLM OT - atherogenic index of plasma OT - early pregnancy OT - gestational diabetes mellitus OT - lipid metabolism OT - prospective cohort EDAT- 2026/10/20 05:30 MHDA- 2026/10/20 05:30 CRDT- 2026/10/20 03:04 PHST- 2026/09/02 00:00 [revised] PHST- 2026/04/22 00:00 [received] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/20 05:30 [medline] PHST- 2026/10/20 05:30 [pubmed] PHST- 2026/10/20 03:04 [entrez] AID - 10.1002/ijgo.71417 [doi] PST - aheadofprint SO - Int J Gynaecol Obstet. 2026 Oct 19. doi: 10.1002/ijgo.71417. PMID- 42897535 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261022 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jul 23 TI - Serum biomarkers and their association with disease severity and perinatal outcomes in preeclampsia: a retrospective study. LID - 10.1186/s12884-026-09691-0 [doi] LID - 1187 AB - BACKGROUND: To investigate the associations of pre-delivery serum blood urea nitrogen (BUN), uric acid (UA), cystatin C (CysC), and serum calcium levels with the occurrence of preeclampsia (PE), disease severity, and birth weight, and to evaluate their discriminatory performance in distinguishing severe preeclampsia (sPE) from PE. METHODS: A total of 328 women with singleton pregnancies who delivered at our hospital between January 2020 and December 2022 and met the inclusion and exclusion criteria were retrospectively enrolled, including 113 women in the normal pregnancy group, 125 in the PE group, and 90 in the sPE group. Maternal demographic characteristics, gestational age at blood sampling, gestational age at delivery, birth weight and related perinatal outcomes, blood pressure measurements, and laboratory parameters were collected. Multivariable binary logistic regression analyses were performed to evaluate the associations between the major laboratory biomarkers and the occurrence of PE and sPE after adjustment for maternal age, body mass index (BMI), nulliparity, assisted reproductive technology (ART) conception, and gestational age at blood sampling. Spearman correlation analysis and multiple linear regression analysis were used to assess the associations between the major laboratory biomarkers and birth weight after further adjustment for gestational age at delivery. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminatory performance of the major laboratory biomarkers and the combined model consisting of BUN, UA, and CysC in distinguishing sPE from PE. The calibration and clinical utility of the combined model were further evaluated using the Hosmer-Lemeshow goodness-of-fit test, calibration plots, and decision curve analysis (DCA). RESULTS: Significant differences in BUN, UA, CysC, and serum calcium levels were observed among the three groups. After adjustment for maternal age, BMI, nulliparity, ART conception, and gestational age at blood sampling, elevated BUN, UA, and CysC levels were independently associated with the occurrence of PE, with odds ratios (ORs) of 3.057, 4.432, and 6.738, respectively (all P < 0.001). Higher serum calcium levels were associated with a lower risk of PE (OR = 0.733, P = 0.019). Among women with PE, only UA remained significantly associated with sPE after adjustment for the above confounding factors (OR = 1.444, 95% confidence interval [CI]: 1.056-1.975, P = 0.021). Correlation analyses showed that BUN, UA, and CysC were negatively correlated with birth weight, whereas serum calcium was not significantly associated with birth weight. After further adjustment for gestational age at delivery, only BUN and UA remained significantly associated with reduced birth weight. ROC analysis showed that the area under the curve (AUC) values for BUN, UA, CysC, and serum calcium (evaluated in the lower-value direction) in distinguishing sPE from PE were 0.610, 0.626, 0.567, and 0.590, respectively. The combined model including BUN, UA, and CysC yielded an AUC of 0.627, with a sensitivity of 37.8%, specificity of 87.2%, positive predictive value of 68.0%, and negative predictive value of 66.1%. The Hosmer-Lemeshow goodness-of-fit test indicated no significant lack of model fit, and decision curve analysis demonstrated that the combined model provided greater net benefit than the treat-all and treat-none strategies across a threshold probability range of approximately 0.34-0.66. CONCLUSIONS: Pre-delivery levels of BUN, UA, CysC, and serum calcium were associated with the occurrence of PE, with UA being independently associated with sPE. BUN and UA remained associated with reduced birth weight after adjustment for gestational age at delivery. However, the discriminatory performance of UA, the other individual biomarkers, and the combined model for distinguishing sPE from PE was limited, and they should not be used alone to determine disease severity. Markedly elevated UA levels may help identify women with PE who require closer clinical monitoring; however, disease severity should still be comprehensively assessed based on blood pressure, proteinuria, clinical symptoms, and evidence of organ dysfunction. CI - (c) 2026. The Author(s). FAU - Feng, Chong AU - Feng C AD - Department of Obstetrics and Gynecology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Hou, Meng AU - Hou M AD - Department of Obstetrics and Gynecology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 1770728313@qq.com. LA - eng PT - Journal Article DEP - 20260723 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Biomarkers) RN - 268B43MJ25 (Uric Acid) RN - SY7Q814VUP (Calcium) RN - 0 (Cystatin C) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pre-Eclampsia/blood/diagnosis MH - Biomarkers/blood MH - Retrospective Studies MH - Adult MH - Uric Acid/blood MH - Birth Weight MH - Severity of Illness Index MH - Blood Urea Nitrogen MH - Calcium/blood MH - Cystatin C/blood MH - ROC Curve MH - Pregnancy Outcome MH - Gestational Age MH - Infant, Newborn PMC - PMC13681745 OTO - NOTNLM OT - Birth weight OT - Blood urea nitrogen OT - Cystatin C OT - Preeclampsia OT - Serum calcium OT - Uric acid COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University (approval number: TREC2025-KY107). All procedures were conducted in accordance with the Declaration of Helsinki. The requirement for informed consent was handled in accordance with the approval and regulations of the ethics committee. Competing interests: The authors declare no competing interests. EDAT- 2026/10/20 05:30 MHDA- 2026/10/20 05:31 PMCR- 2026/07/23 CRDT- 2026/10/20 00:41 PHST- 2026/05/05 00:00 [received] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/10/20 05:31 [medline] PHST- 2026/10/20 05:30 [pubmed] PHST- 2026/10/20 00:41 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1186/s12884-026-09691-0 [pii] AID - 9691 [pii] AID - 10.1186/s12884-026-09691-0 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jul 23;26(1):1187. doi: 10.1186/s12884-026-09691-0. PMID- 42897504 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261022 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 24 TI - Monitoring metabolic health in the adolescent population of Rarotonga: a multi-year cross-sectional study from 2016 to 2023. LID - 10.1186/s12889-026-28637-x [doi] LID - 3015 AB - BACKGROUND: The Cook Islands, a small Pacific nation, carries a high burden of obesity (75%) and non-communicable disease (NCD) among adults. Primary prevention before adulthood, including school-based strategies, is a priority. Local evidence is crucial but challenging in resource-limited, low-population settings. This study presents data on the prevalence of risk factors associated with metabolic syndrome (MetS) among adolescents in Rarotonga, the main island of the Cook Islands. METHODS: A multi-year cross-sectional survey of NCD risk factors in Year 9 students (median age: 13.8 years) between 2016-2019 and 2022-2023 (n = 783) represented 65% of the cohort (n = 1214). Data analysis used descriptive statistics with 5% significance testing. RESULTS: The prevalence of risk factors include: 22.1% overweight, 37.6% obese; 39.1% Waist-to-Height ratio (WtHR) > 0.5 (study years: chi(2) p < 0.001); 9.4% high Blood Pressure (BP) (gender: chi(2) p < 0.001, study years: chi(2) p = 0.005); 8.1% elevated Total blood Cholesterol (TC) (study years: chi(2) p = 0.003); 37.1% elevated fasting Blood Sugar Levels (fBSL) (study years: chi(2) p = 0.007). Where all measures were available (n = 261), 27.6% of participants were living with obesity and >/= 2 risk factors. Body-Mass-Index-for-Age (BMI-for-age) percentile and WtHR risk category proportions were positively correlated (chi(2) p < 0.001) with 78.9% of those with obesity falling into the increased risk WtHR category. Significant associations (all p < 0.001) were identified between elevated BP and BMI-for-age categories, WtHR, and TC levels. CONCLUSIONS: The multi-year cross-sectional approach enabled valid data within a low-resource setting that confirmed extremely high levels of overweight and obesity in the Year 9 student population. We argue that including waist circumference measures alongside BMI-for-age was a first step to enabling greater depth of understanding of the risk levels in this population. Some risk factors associated with MetS have been assessed, but investment in improving glucose and lipid monitoring is strongly recommended. This study highlights the importance of monitoring paediatric MetS in the Cook Islands. It suggests that it should be used longitudinally to inform the impact of interventions from early life through to adolescence. CI - (c) 2026. The Author(s). FAU - Bay, Jacquie L AU - Bay JL AUID- ORCID: 0000-0003-0139-1050 AD - Liggins Institute, Waipapa Taumata Rau, University of Auckland, Private Bag 92109, Victoria Street West, Auckland, 1142, New Zealand. j.bay@auckland.ac.nz. FAU - John, Tania AU - John T AD - Te Marae Ora, Cook Islands Ministry of Health, Rarotonga, Cook Islands. FAU - Renelle, Amy AU - Renelle A AD - Liggins Institute, Waipapa Taumata Rau, University of Auckland, Private Bag 92109, Victoria Street West, Auckland, 1142, New Zealand. FAU - Ngamata, Karen AU - Ngamata K AD - Te Marae Ora, Cook Islands Ministry of Health, Rarotonga, Cook Islands. FAU - Barrett-Watson, Celeste AU - Barrett-Watson C AD - Maraurau o te Pae Api'i, Cook Islands Ministry of Education, Rarotonga, Cook Islands. FAU - Trask, Suzanne A AU - Trask SA AD - Liggins Institute, Waipapa Taumata Rau, University of Auckland, Private Bag 92109, Victoria Street West, Auckland, 1142, New Zealand. FAU - Vickers, Mark H AU - Vickers MH AD - Liggins Institute, Waipapa Taumata Rau, University of Auckland, Private Bag 92109, Victoria Street West, Auckland, 1142, New Zealand. FAU - Cochrane, Danielle Tungane AU - Cochrane DT AD - Liggins Institute, Waipapa Taumata Rau, University of Auckland, Private Bag 92109, Victoria Street West, Auckland, 1142, New Zealand. AD - Maraurau o te Pae Api'i, Cook Islands Ministry of Education, Rarotonga, Cook Islands. FAU - Bates, Metua AU - Bates M AD - Te Marae Ora, Cook Islands Ministry of Health, Rarotonga, Cook Islands. LA - eng GR - PF-1-280 and PF-11-613/Ministry of Foreign Affairs and Trade, New Zealand/ GR - Ref 20/284/Health Research Council of New Zealand/ PT - Journal Article DEP - 20260724 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - *Metabolic Syndrome/epidemiology MH - Female MH - Adolescent MH - Risk Factors MH - Prevalence MH - Polynesia/epidemiology MH - Micronesia/epidemiology PMC - PMC13681813 OTO - NOTNLM OT - Adolescent OT - Cook Islands OT - Metabolic syndrome OT - Non-communicable disease OT - Pacific Island OT - School-based health promotion COIS- Declarations. Ethics approval and consent to participate: This study was conducted using deidentified health system data from the Te Marae Ora Cook Islands Ministry of Health database of school health check records. These data are routine health records collected with informed parental consent from children under the age of 16 following protocols specified by Te Marae Ora, Cook Islands Ministry of Health. The Cook Islands National Research Committee deemed that as the data were deidentified, the study did not require formal approval. No identifiable personal health information was used in this research. Approval for University of Auckland staff to work with Te Marae Ora staff on deidentified data from the Cook Islands database of school health check records was obtained from Auckland Health Research Ethics Committee Ref. 24,668. All procedures followed were in accordance with the ethical standards of Te Marae Ora, Cook Islands Ministry of Health, the Cook Islands National Research Committee, the Auckland Health Research Ethics Committee and with the Helsinki Declaration of 1975, as revised in 2024. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/20 05:30 MHDA- 2026/10/20 05:31 PMCR- 2026/07/24 CRDT- 2026/10/20 00:31 PHST- 2025/04/02 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/10/20 05:31 [medline] PHST- 2026/10/20 05:30 [pubmed] PHST- 2026/10/20 00:31 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.1186/s12889-026-28637-x [pii] AID - 28637 [pii] AID - 10.1186/s12889-026-28637-x [doi] PST - epublish SO - BMC Public Health. 2026 Jul 24;26(1):3015. doi: 10.1186/s12889-026-28637-x. PMID- 42896171 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261019 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Oct 19 TI - Tuberculosis Among Artisanal Miners in the Mulongo Health Zone, Democratic Republic of Congo: Unmatched Case-Control Study. PG - e93635 LID - 10.2196/93635 [doi] AB - BACKGROUND: Tuberculosis (TB) remains a major global health challenge, with 10.6 million new cases and 1.3 million deaths reported in 2022. Artisanal miners in sub‑Saharan Africa are particularly vulnerable due to poverty, overcrowded living conditions, and high HIV prevalence. In the Democratic Republic of Congo (DRC), TB prevalence among miners is high, yet determinants remain insufficiently studied. OBJECTIVE: This study aimed to identify sociodemographic, behavioral, and clinical factors associated with TB among artisanal miners in the Mulongo health zone, Haut‑Lomami Province, DRC. METHODS: We conducted an unmatched case-control study among miners aged >/=15 years. Data were collected using a validated questionnaire covering socioeconomic, behavioral, and biomedical variables. Interviewers were blinded to TB status to minimize bias. Determinants were assessed using bivariate and multivariable logistic regression. RESULTS: Poverty was strongly associated with TB (adjusted odds ratio [aOR] 3.16, 95% CI 1.95-5.11; P<.001). Primary education was associated with increased TB risk (aOR 2.78, 95% CI 1.04-7.44; P=.04), while secondary education showed a borderline association (aOR 2.53, 95% CI 0.93-6.89; P=.07). Higher education was protective (aOR 0.62, 95% CI 0.40-0.95; P=.03). Poor knowledge of TB transmission (aOR 2.11, 95% CI 1.16-3.83; P=.02), cause (aOR 1.79, 95% CI 1.00-3.20; P=.049), and diagnosis (aOR 2.49, 95% CI 1.48-4.17; P=.001) were consistently linked to higher vulnerability. HIV infection was significantly associated with TB (aOR 4.65, 95% CI 1.00-21.74; P=.049). Overcrowding was more frequent among TB cases, but in adjusted models, the association was borderline (aOR 1.65, 95% CI 0.95-2.85; P=.07). Tobacco use (aOR 1.47, 95% CI 0.83-2.61; P=.18), alcohol consumption (aOR 1.18, 95% CI 0.70-1.98; P=.54), and nutritional status (aOR 1.36, 95% CI 0.78-2.37; P=.28) were not significantly associated with TB. CONCLUSIONS: TB among artisanal miners appears to be driven primarily by poverty, limited education, poor knowledge, and HIV infection. Overcrowding showed a suggestive but nonsignificant association. Integrated interventions should prioritize poverty alleviation, improved housing, tailored health education, and strengthened TB and HIV services, while further studies are needed to clarify the role of overcrowding and other contextual factors. CI - (c)Josue Mutangala Muloye, Fiston Ilunga Mbayo, Jacques Muteba Kakoma, Francois Kitobo Mashika, Jean Claude Banze Kabwe Ilunga, Pacifique Kanku Wa Ilunga, Gloire Kasongo Lupitshi, Didy Lwamba Kabiya, Paulin Beya Wa Bitadi Mutombo. Originally published in JMIR Formative Research (https://formative.jmir.org), 19.10.2026. FAU - Mutangala Muloye, Josue AU - Mutangala Muloye J AUID- ORCID: 0009-0006-4941-1558 AD - Health Zone of Lwamba, Lwamba, Haut Lomami, The Democratic Republic of The Congo. FAU - Ilunga Mbayo, Fiston AU - Ilunga Mbayo F AUID- ORCID: 0009-0004-0354-721X AD - School of Public Health, University of Malemba Nkulu, Malemba Nkulu, Haut Lomami, The Democratic Republic of The Congo. AD - General Reference Hospital of Malemba Nkulu, Malemba Nkulu, Haut Lomami, The Democratic Republic of The Congo. FAU - Muteba Kakoma, Jacques AU - Muteba Kakoma J AUID- ORCID: 0009-0001-4910-2185 AD - University of Kamina, Kamina, Haut-Lomami, The Democratic Republic of The Congo. FAU - Kitobo Mashika, Francois AU - Kitobo Mashika F AUID- ORCID: 0009-0002-4622-0052 AD - Provincial Health Division of Haut-Lomami, Kamina, Haut Lomami, The Democratic Republic of The Congo. FAU - Banze Kabwe Ilunga, Jean Claude AU - Banze Kabwe Ilunga JC AUID- ORCID: 0009-0005-9882-4933 AD - University of Kamina, Kamina, Haut-Lomami, The Democratic Republic of The Congo. FAU - Kanku Wa Ilunga, Pacifique AU - Kanku Wa Ilunga P AUID- ORCID: 0009-0005-4738-2549 AD - University of Kamina, Kamina, Haut-Lomami, The Democratic Republic of The Congo. FAU - Kasongo Lupitshi, Gloire AU - Kasongo Lupitshi G AUID- ORCID: 0009-0005-4731-9750 AD - School of Public Health, University of Malemba Nkulu, Malemba Nkulu, Haut Lomami, The Democratic Republic of The Congo. FAU - Lwamba Kabiya, Didy AU - Lwamba Kabiya D AUID- ORCID: 0009-0002-5529-3456 AD - Higher Institute of Medical Techniques of Kamina, Kamina, Haut Lomami, The Democratic Republic of The Congo. FAU - Mutombo, Paulin Beya Wa Bitadi AU - Mutombo PBWB AUID- ORCID: 0000-0003-4663-9419 AD - School of Public Health, Medicine, University of Kinshasa, Kinshasa, Kinshasa, The Democratic Republic of The Congo. LA - eng PT - Journal Article DEP - 20261019 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Democratic Republic of the Congo/epidemiology MH - Male MH - Case-Control Studies MH - Adult MH - *Tuberculosis/epidemiology MH - *Miners/statistics & numerical data MH - Middle Aged MH - Female MH - Prevalence MH - Surveys and Questionnaires MH - Risk Factors MH - Adolescent MH - Young Adult MH - Poverty MH - HIV Infections/epidemiology OTO - NOTNLM OT - Democratic Republic of Congo OT - HIV OT - artisanal miners OT - case-control study OT - overcrowding OT - poverty OT - tuberculosis EDAT- 2026/10/19 17:31 MHDA- 2026/10/19 23:30 CRDT- 2026/10/19 16:53 PHST- 2026/02/16 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/14 00:00 [revised] PHST- 2026/10/19 23:30 [medline] PHST- 2026/10/19 17:31 [pubmed] PHST- 2026/10/19 16:53 [entrez] AID - v10i1e93635 [pii] AID - 10.2196/93635 [doi] PST - epublish SO - JMIR Form Res. 2026 Oct 19;10:e93635. doi: 10.2196/93635. PMID- 42896087 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261022 IS - 1460-2083 (Electronic) IS - 0964-6906 (Print) IS - 0964-6906 (Linking) VI - 35 IP - 21 DP - 2026 Oct 13 TI - The monogenic forms of obesity in Saudi families. LID - 10.1093/hmg/ddag054 [doi] LID - ddag054 AB - BACKGROUND: Obesity is a multifactorial disorder with a substantial yet incompletely defined genetic component. Rare monogenic variants, particularly in consanguineous populations, may account for part of the 'missing heritability.' OBJECTIVES: To delineate the genetic contribution to severe obesity in individuals from Saudi Arabia by pinpointing known and novel monogenic variants in families presenting with extreme phenotypes. METHODS: Eight multiplex Saudi families (each comprising 9 members; range: lean body weight to severe obesity) were enrolled. Adults had a BMI of >/=30 kg/m2; children exceeded the 90th percentile (overweight) or the 97th percentile (obese). Whole-exome sequencing (WES) was performed on samples collected from two children in each family, including one child with obesity and one control child without obesity. Variant calling files were filtered for quality, frequency < 1%, and predicted functional impact. Candidate loci were prioritized using Moon (Diploid) software and manual curation, then validated by Sanger sequencing. RESULTS: Initial filtering revealed 40 rare, potentially pathogenic variants in 35 genes shared among affected relatives. Prioritization highlighted 28 variants in 19 candidate genes, encompassing established obesity-related genes (e.g. LEPR, MC4R, BDNF) and putative novel loci linked to appetite regulation, lipid metabolism, and energy balance. Segregation analysis identified both heterozygous and homozygous variants across affected individuals, reflecting variability in inheritance patterns. Seven previously reported candidate genes did not show pathogenic variants in this cohort. Carriers of prioritized variants exhibited significantly higher BMI z-scores than non-carriers (P < 0.01), underscoring a clear genotype-phenotype correlation. CONCLUSION: This study broadens the catalog of genes associated with obesity in the Saudi population and demonstrates the value of studying extreme phenotypes in consanguineous families. Both previously recognized and novel variants were identified in association with severe, early-onset obesity, reflecting genetic heterogeneity across families rather than a single underlying mechanism. These findings provide a foundation for improved genetic characterization, tailored counseling, and future functional studies. CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Almolafikh, Sultanah Turki AU - Almolafikh ST AD - Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University,, P.O. Box 2460, Riyadh 11451, Saudi Arabia. FAU - Alshatwi, Ali A AU - Alshatwi AA AD - Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University,, P.O. Box 2460, Riyadh 11451, Saudi Arabia. FAU - Orfali, Razan AU - Orfali R AUID- ORCID: 0000-0002-0584-4013 AD - Department of Pharmacology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia. FAU - AlSaud, Haya AU - AlSaud H AD - King Faisal Specialist Hospital Research Centre, Riyadh, 13458, Saudi Arabia. AD - King Abdulaziz City for Science and Technology, Riyadh 12354, Saudi Arabia. AD - Hevolution Foundation, King Saud University, Riyadh 13519, Saudi Arabia. LA - eng GR - Research Center in King Faisal Specialist Hospital in Riyadh/ PT - Journal Article PL - England TA - Hum Mol Genet JT - Human molecular genetics JID - 9208958 RN - 0 (Receptors, Leptin) RN - 0 (Receptor, Melanocortin, Type 4) RN - 0 (LEPR protein, human) RN - 0 (MC4R protein, human) SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Pedigree MH - Female MH - *Obesity/genetics/pathology/epidemiology MH - Male MH - Child MH - *Genetic Predisposition to Disease MH - Adult MH - Receptors, Leptin/genetics MH - Exome Sequencing MH - Phenotype MH - Consanguinity MH - Receptor, Melanocortin, Type 4/genetics MH - Body Mass Index MH - Adolescent PMC - PMC13679745 OTO - NOTNLM OT - consanguineous families OT - heterozygosity OT - homozygosity OT - monogenic OT - obesity OT - rare disease OT - syndromic of obesity COIS- The authors declare no conflict of interest. EDAT- 2026/10/19 17:31 MHDA- 2026/10/19 17:32 PMCR- 2026/10/19 CRDT- 2026/10/19 15:24 PHST- 2025/10/17 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/10/19 17:32 [medline] PHST- 2026/10/19 17:31 [pubmed] PHST- 2026/10/19 15:24 [entrez] PHST- 2026/10/19 00:00 [pmc-release] AID - 8943647 [pii] AID - ddag054 [pii] AID - 10.1093/hmg/ddag054 [doi] PST - ppublish SO - Hum Mol Genet. 2026 Oct 13;35(21):ddag054. doi: 10.1093/hmg/ddag054. PMID- 42895862 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261019 IS - 1743-8942 (Electronic) IS - 0167-482X (Linking) VI - 47 IP - 1 DP - 2026 Dec 31 TI - Psychological birth trauma and breastfeeding self-efficacy: a parallel mediation model of resilience and bonding. PG - 2746741 LID - 10.1080/0167482X.2026.2746741 [doi] AB - BACKGROUND: Psychological birth trauma (PBT) is associated with early breastfeeding difficulties, but pathways linking PBT to reduced breastfeeding self-efficacy (BSE) remain underexplored. OBJECTIVES: To examine statistical associations among PBT, BSE, mother-infant bonding, and psychological resilience, evaluating bonding and resilience as parallel mediators. METHODS: In this cross-sectional study, 528 postpartum women recruited from a tertiary maternity hospital completed validated scales assessing PBT, BSE, bonding, and resilience. Data were analyzed using bivariate correlations and PROCESS Macro. RESULTS: PBT was negatively correlated with BSE (r = -0.558), resilience (r = -0.559), and bonding (r = -0.459; all p < 0.001). Parallel mediation revealed significant indirect pathways via bonding (B = -0.070, 95% CI [-0.112, -0.026]) and resilience (B = -0.107, 95% CI [-0.166, -0.057]), with a total indirect effect of B = -0.177 (95% CI [-0.233, -0.121]). The direct association between PBT and BSE remained significant (B = -0.350, 95% CI [-0.435, -0.265]). CONCLUSIONS: PBT, dyadic bonding, and resilience demonstrate robust concurrent associations with initial maternal breastfeeding self-efficacy. While these cross-sectional findings delineate patterns of statistical covariance rather than temporal or causal pathways, they highlight the relevance of integrating relational and intrapersonal screening into early postpartum maternal care. FAU - Yan, Liting AU - Yan L AD - School of Medicine, Department of Obstetrics, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Huang, Lingling AU - Huang L AD - School of Medicine, Department of Obstetrics, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Wang, Shaofang AU - Wang S AD - School of Medicine, Nursing Department, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Chen, Ting AU - Chen T AD - School of Medicine, Department of Obstetrics, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Zhao, Lili AU - Zhao L AD - School of Medicine, Nursing Department, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Huang, Yinying AU - Huang Y AD - School of Medicine, Nursing Department, Women and Children's Hospital, Xiamen University, Xiamen, China. LA - eng PT - Journal Article DEP - 20261019 PL - England TA - J Psychosom Obstet Gynaecol JT - Journal of psychosomatic obstetrics and gynaecology JID - 8308648 SB - IM MH - Humans MH - Female MH - *Self Efficacy MH - *Breast Feeding/psychology MH - *Object Attachment MH - Cross-Sectional Studies MH - Adult MH - *Resilience, Psychological MH - *Mother-Child Relations/psychology MH - Postpartum Period/psychology MH - Young Adult MH - *Mothers/psychology MH - *Parturition/psychology MH - Pregnancy OTO - NOTNLM OT - Psychological birth trauma OT - breastfeeding self-efficacy OT - mediation analysis OT - mother-infant bonding OT - psychological resilience EDAT- 2026/10/19 17:31 MHDA- 2026/10/19 17:32 CRDT- 2026/10/19 12:43 PHST- 2026/10/19 17:32 [medline] PHST- 2026/10/19 17:31 [pubmed] PHST- 2026/10/19 12:43 [entrez] AID - 10.1080/0167482X.2026.2746741 [doi] PST - ppublish SO - J Psychosom Obstet Gynaecol. 2026 Dec 31;47(1):2746741. doi: 10.1080/0167482X.2026.2746741. Epub 2026 Oct 19. PMID- 42895271 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261022 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 16 DP - 2026 Oct 19 TI - External validation and application of machine learning models for obesity in Chinese children and adolescents per Chinese and WHO growth standards. PG - 04299 LID - 10.7189/jogh.16.04299 [doi] LID - 04299 AB - BACKGROUND: Childhood and adolescent obesity is a growing global public health challenge, underscoring the need for reliable tools to identify individuals at high risk. We aimed to develop, validate, and deploy machine learning (ML) models for predicting obesity in children and adolescents aged 3-18 years using multi-domain risk factors per Chinese and World Health Organization (WHO) growth standards, with an online tool for clinical and public health translation. METHODS: We conducted a population-based cross-sectional study. We used data from 22,555 participants in Beijing (2022, 2024) for training/internal validation, and data from 5,343 participants in Tangshan (2020) for external validation. We defined obesity using both Chinese and WHO growth standards. We analysed 38 features across 5 domains; we selected key predictors using least absolute shrinkage and selection operator regression. We evaluated 4 ML models using 28 performance metrics, with SHapley Additive exPlanations enhancing interpretability. RESULTS: We retained 5 features per the Chinese growth standards and 12 per the WHO growth standards. Age, maternal body mass index (BMI), paternal BMI, screen time, and birthweight were consistent predictors. The neural network achieved optimal performance per Chinese growth standards (area under the receiver operating characteristic curve (AUROC) = 0.735), and eXtreme gradient boosting performed best per WHO growth standards (AUROC = 0.736), with the corresponding external validation AUROCs of 0.699 and 0.707. We subsequently deployed user-friendly online prediction tools for translation. CONCLUSIONS: We identified two interpretable ML models for obesity in children and adolescents per both Chinese and WHO growth standards, each demonstrating modest but reliable predictive performance. CI - (c) 2026 The Authors. FAU - Zheng, Fangjieyi AU - Zheng F AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Wang, Xiaoqian AU - Wang X AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. AD - Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Xue, Mei AU - Xue M AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Qiong AU - Wang Q AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Zhang, Wenqian AU - Zhang W AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Zhang, Zhixin AU - Zhang Z AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China. FAU - Niu, Wenquan AU - Niu W AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20261019 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 RN - Chinese people SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Body Mass Index MH - China/epidemiology MH - Cross-Sectional Studies MH - *Machine Learning MH - *Pediatric Obesity/epidemiology MH - Predictive Learning Models MH - Risk Factors MH - World Health Organization MH - East Asian People PMC - PMC13679347 OTO - NOTNLM OT - Chinese and WHO growth standards OT - children and adolescents OT - external validation OT - machine learning OT - obesity COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2026/10/19 11:36 MHDA- 2026/10/19 11:37 PMCR- 2026/10/19 CRDT- 2026/10/19 08:35 PHST- 2026/10/19 11:37 [medline] PHST- 2026/10/19 11:36 [pubmed] PHST- 2026/10/19 08:35 [entrez] PHST- 2026/10/19 00:00 [pmc-release] AID - jogh-16-04299 [pii] AID - 10.7189/jogh.16.04299 [doi] PST - epublish SO - J Glob Health. 2026 Oct 19;16:04299. doi: 10.7189/jogh.16.04299. PMID- 42895101 OWN - NLM STAT- Publisher LR - 20261019 IS - 1619-3997 (Electronic) IS - 0300-5577 (Linking) DP - 2026 Oct 20 TI - Biochemical and anthropometric assessment of nutritional status at discharge in very-low-birth-weight infants: a retrospective cohort study. LID - 10.1515/jpm-2026-0439 [doi] AB - OBJECTIVES: To evaluate nutritional status at discharge in VLBW infants using biochemical and composite nutritional indices, and to examine their relationship with extrauterine growth restriction (EUGR; also termed "growth faltering" in more recent literature). METHODS: This retrospective cohort study included 124 very low birth weight infants (1). RESULTS: EUGR occurred in 43.5 % (cross-sectional) and 38.7 % (longitudinal) of infants. Hypouremia (18.0 %) and hypocreatininemia (12.0 %) were the most frequent abnormalities. Composite outcomes were associated with lower gestational age and small-for-gestational-age status. Cross-sectional EUGR was nominally associated with CNDO (aOR 3.72, p=0.023) and CMPDO (aOR 3.96, p=0.031) but not CPDO; given testing across four correlated composite outcomes without formal correction for multiple comparisons, these associations should be regarded as nominal. AUCs for the four composites ranged narrowly from 0.761 to 0.794 and were not formally compared. Anthropometric differences were not significant. CONCLUSIONS: Subclinical biochemical deficiency was common at discharge despite non-significant anthropometric differences. Composite biochemical indices showed similar, moderate discriminative performance across definitions; findings are hypothesis-generating and require external, prospective validation before any composite can be considered superior or used clinically. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Yaprak, Deniz AU - Yaprak D AUID- ORCID: 0000-0002-8130-7877 AD - Department of Pediatrics, Division of Neonatology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkiye. FAU - Saygili Karagol, Belma AU - Saygili Karagol B AUID- ORCID: 0000-0003-3728-9613 AD - Department of Pediatrics, Division of Neonatology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20261020 PL - Germany TA - J Perinat Med JT - Journal of perinatal medicine JID - 0361031 SB - IM OTO - NOTNLM OT - biochemical markers OT - composite outcomes OT - extrauterine growth restriction OT - malnutrition OT - neonatal nutrition OT - very low birth weight EDAT- 2026/10/19 11:36 MHDA- 2026/10/19 11:36 CRDT- 2026/10/19 06:04 PHST- 2026/07/25 00:00 [received] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/19 11:36 [medline] PHST- 2026/10/19 11:36 [pubmed] PHST- 2026/10/19 06:04 [entrez] AID - jpm-2026-0439 [pii] AID - 10.1515/jpm-2026-0439 [doi] PST - aheadofprint SO - J Perinat Med. 2026 Oct 20. doi: 10.1515/jpm-2026-0439. PMID- 42894603 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261019 LR - 20261020 IS - 0019-5413 (Print) IS - 1998-3727 (Electronic) IS - 0019-5413 (Linking) VI - 60 IP - 11 DP - 2026 Nov TI - Objective Return-to-Sport (RTS) Decision Frameworks for Adolescent Shoulder and Elbow Injuries: Tests, Thresholds and Exercise Targets. PG - 3091-3106 LID - 10.1007/s43465-026-01927-7 [doi] AB - BACKGROUND: Adolescent shoulder and elbow injuries are increasing due to sports specialization and year-round training, yet return-to-sport decisions typically rely on adult-derived heuristics that fail to address the unique physiology, growth plate vulnerability, and recovery needs of developing athletes aged 10-19 years. OBJECTIVE: This review proposes a novel, objective three-pillar RTS framework integrating: (1) foundational tissue capacity, (2) dynamic movement quality and neuromuscular control, and (3) sport-specific load tolerance. We synthesize current evidence to establish provisional, consensus-based adolescent thresholds and provide a practical bedside toolkit for immediate clinical implementation. METHODS: We conducted a narrative synthesis of contemporary original evidence, consensus recommendations, and validation studies relevant to adolescent shoulder and elbow rehabilitation. Evidence was critically appraised for youth-specific validation, with explicit distinction between evidence-based interventions and emerging aspirational technologies requiring prospective adolescent cohort validation. RESULTS: We propose a hybrid benchmarking model combining limb symmetry indices (LSI >/=90%) with population-referenced percentiles (>/=25th percentile for age/sex/sport) as provisional, consensus-based thresholds. A three-stage progression is outlined: Clinic-ready (pain-free ROM, isometric IR/ER LSI >/=90%), Training-ready (dynamic rotational LSI >/=90%, preserved scapular kinematics), and Game-ready (sport-specific tolerance with 5% velocity loss during simulated exposure). We provide a low-resource bedside toolkit including belt-stabilized hand-held dynamometry, Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST), Push-Up Plus, Athletic Shoulder positions, seated medicine-ball throw, and simple interval tolerance simulations with specific protocols and thresholds. A stepwise algorithm advances from capacity --> movement quality --> load tolerance with targeted remediation at each gate. CONCLUSION: Moving beyond time-based or adult-derived heuristics, this objective multidimensional framework aligns tissue recovery with sport-specific demands through quantifiable metrics. While provisional thresholds require further adolescent validation, the framework offers an evidence-guided pathway that mitigates reinjury risk, restores performance, and supports safe reintegration into sport. Implementation requires adolescent-specific normative databases, stakeholder communication, and cost-effective technological integration for equitable adoption. CI - (c) Indian Orthopaedics Association 2026. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Li, JiaYu AU - Li J AD - Wushu Department, Wushu College of Henan University, Henan University, Kaifeng, 475000 Henan China. ROR: https://ror.org/003xyzq10. GRID: grid.256922.8. ISNI: 0000 0000 9139 560X FAU - Geng, ShengKai AU - Geng S AD - Wushu Department, Wushu College of Henan University, Henan University, Kaifeng, 475000 Henan China. ROR: https://ror.org/003xyzq10. GRID: grid.256922.8. ISNI: 0000 0000 9139 560X LA - eng PT - Journal Article PT - Review DEP - 20260813 PL - Switzerland TA - Indian J Orthop JT - Indian journal of orthopaedics JID - 0137736 PMC - PMC13676577 OTO - NOTNLM OT - Adolescent athletes OT - Objective assessment OT - Rehabilitation framework OT - Return-to-sport criteria OT - Shoulder and elbow injuries COIS- Conflict of InterestThe authors declare no financial or other relationships with commercial entities that could be perceived to influence the content of this manuscript. No author has received honoraria, consulting fees, in-kind equipment, or research support from device manufacturers discussed in this review. All technology references in the manuscript are illustrative and device-agnostic; when specific systems are mentioned they are examples only and not endorsements. EDAT- 2026/10/19 05:30 MHDA- 2026/10/19 05:31 PMCR- 2027/08/13 CRDT- 2026/10/19 04:00 PHST- 2025/12/13 00:00 [received] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/10/19 05:31 [medline] PHST- 2026/10/19 05:30 [pubmed] PHST- 2026/10/19 04:00 [entrez] PHST- 2027/08/13 00:00 [pmc-release] AID - 1927 [pii] AID - 10.1007/s43465-026-01927-7 [doi] PST - epublish SO - Indian J Orthop. 2026 Aug 13;60(11):3091-3106. doi: 10.1007/s43465-026-01927-7. eCollection 2026 Nov. PMID- 42893551 OWN - NLM STAT- Publisher LR - 20261018 IS - 1475-357X (Print) IS - 1475-357X (Linking) DP - 2026 Oct 18 TI - Longitudinal associations between dietary intake and common mental disorders among adolescents in Australia. LID - 10.1111/camh.70129 [doi] AB - BACKGROUND: There is a need for more longitudinal research exploring temporal associations between diet quality and common mental disorders (CMDs) during adolescence. This study examined prospective associations between indicators of adolescents' diet quality (fruit, vegetable, sugar-sweetened beverage [SSB] intakes) and risk of depression and anxiety onset over 3 years. We hypothesised that higher fruit and vegetable intake, and lower SSB intake, would be associated with lower risk of CMDs. METHODS: 6537 Australian adolescents (mean age 12.65 years at baseline) completed surveys at baseline, 1-, 2- and 3-year follow-ups. We fitted Generalised Estimating Equations Poisson regression models to assess longitudinal associations between daily servings of fruit, vegetables and SSBs, and risk of depression and anxiety onset (binary cut-points on validated scales) over 3 years. Models were re-run for males and females. Analyses excluded participants who met thresholds for depression or anxiety at baseline to increase confidence that diet predicted CMD onset. RESULTS: Higher fruit intake was associated with lower risk of depression (adjusted RR: 0.87, 95% CI: 0.82-0.93) and anxiety (adjusted RR: 0.93, 95% CI: 0.87-0.99) over 3 years, with limited evidence of sex differences. Higher SSB intake (log-transformed) was associated with higher CMD risk for both sexes, but more strongly for males (depression: adjusted RR: 3.25, 95% CI: 2.02-5.23; anxiety: adjusted RR: 5.50, 95% CI: 3.39-8.90) than females (depression: adjusted RR: 3.10, 95% CI: 2.06-4.68; anxiety: adjusted RR: 2.04, 95% CI: 1.23-3.37). Results inform the Global burden of disease Lifestyle And mental Disorders project (DERR2-https://doi.org/10.2196/65576). CONCLUSIONS: Longitudinal research exposing temporal associations between diet and CMDs may inform prevention/intervention efforts targeting modifiable risk factors for CMDs. CI - (c) 2026 The Author(s). Child and Adolescent Mental Health published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. FAU - Davidson, Lily AU - Davidson L AUID- ORCID: 0000-0002-2811-0856 AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Ashtree, Deborah N AU - Ashtree DN AUID- ORCID: 0000-0003-3680-3860 AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Osman, Bridie AU - Osman B AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Smout, Scarlett AU - Smout S AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Newton, Nicola C AU - Newton NC AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Gardner, Lauren A AU - Gardner LA AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - O'Neil, Adrienne AU - O'Neil A AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Jacka, Felice AU - Jacka F AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. AD - Centre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, Vic., Australia. AD - College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, Qld, Australia. FAU - Orr, Rebecca AU - Orr R AUID- ORCID: 0000-0002-2422-5533 AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Lane, Melissa AU - Lane M AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Teesson, Maree AU - Teesson M AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Champion, Katrina E AU - Champion KE AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. AD - School of Public Health, The University of Sydney, Sydney, NSW, Australia. LA - eng GR - APP11349009/Centre of Research Excellence in Prevention and Early Intervention of Mental Illness and Substance Use/ GR - APP1078407/Australian National Health and Medical Research Council/ GR - APP1120641/Australian National Health and Medical Research Council/ GR - APP1166377/Australian National Health and Medical Research Council/ GR - Paul Ramsay Foundation/ PT - Journal Article DEP - 20261018 PL - England TA - Child Adolesc Ment Health JT - Child and adolescent mental health JID - 101142157 SB - IM OTO - NOTNLM OT - Adolescent OT - anxiety OT - depression OT - diet OT - mental disorder OT - prospective studies EDAT- 2026/10/18 17:32 MHDA- 2026/10/18 17:32 CRDT- 2026/10/18 15:03 PHST- 2026/09/03 00:00 [accepted] PHST- 2026/10/18 17:32 [medline] PHST- 2026/10/18 17:32 [pubmed] PHST- 2026/10/18 15:03 [entrez] AID - 10.1111/camh.70129 [doi] PST - aheadofprint SO - Child Adolesc Ment Health. 2026 Oct 18. doi: 10.1111/camh.70129. PMID- 42893521 OWN - NLM STAT- MEDLINE DCOM- 20261018 LR - 20261020 IS - 1460-6984 (Electronic) IS - 1368-2822 (Print) IS - 1368-2822 (Linking) VI - 61 IP - 6 DP - 2026 Nov-Dec TI - Cultural and Linguistic Adaptation of Diagnostic Language Assessments: A Scoping Review. PG - e70357 LID - 10.1111/1460-6984.70357 [doi] LID - e70357 AB - BACKGROUND: Diagnostic language assessments are central to identifying developmental language disorder; however, many widely used tools were developed and normed within monolingual Western contexts. Their application in multilingual and multicultural settings raises concerns about linguistic, cultural and psychometric validity. Although adaptation of diagnostic tools is frequently reported, the scope and quality of published adaptation research has not been systematically mapped. AIMS: This scoping review aimed to map the literature on the cultural and linguistic adaptation of diagnostic language assessment tools for multilingual and multicultural child populations, to describe the adaptation and validation approaches used, and to identify gaps relevant to future diagnostic tool development. METHODS AND PROCEDURES: A scoping review was conducted following the Arksey and O'Malley framework and reported in line with PRISMA-ScR guidelines. Searches were conducted across four electronic databases for peer-reviewed studies published between 2014 and 2025. Studies (n = 14) were included if they reported the translation, cultural adaptation, or contextual modification of diagnostic language assessments for children aged 3-12 years. Data were charted on study characteristics, assessment tools, adaptation frameworks, validation methods and reported challenges. OUTCOMES AND RESULTS: Fourteen studies met inclusion criteria, representing 10 countries. Adapted tools assessed a range of language domains. Most studies reported multi-step adaptation processes and referenced established international frameworks; however, the depth of cultural adaptation and the rigour of psychometric validation varied substantially. CONCLUSIONS AND IMPLICATIONS: Diagnostic language assessment adaptation research remains fragmented and methodologically inconsistent. The limited evidence base across diverse multilingual settings highlights an urgent need for contextually grounded, psychometrically robust diagnostic tools to support equitable assessment in multilingual settings. WHAT THIS PAPER ADDS: What is already known on this subject Diagnostic language assessments are often developed in monolingual Western contexts and may not be valid for multilingual children. Translation and cultural adaptation of assessments are increasingly reported, but practices vary widely. What this paper adds to existing knowledge This review provides a systematic mapping of diagnostic language assessment adaptations, highlighting substantial variation in adaptation depth and validation quality. Only 14 studies across 10 countries were identified, indicating that the evidence base for culturally and linguistically adapted diagnostic language assessments remains limited and geographically fragmented. What are the potential or actual clinical implications of this work? Clinicians should exercise caution when using translated diagnostic tools and adopt multi-method, culturally responsive assessment practices. The findings provide a framework to guide future diagnostic tool adaptation and development in multilingual contexts. CI - (c) 2026 The Author(s). International Journal of Language & Communication Disorders published by John Wiley & Sons Ltd on behalf of Royal College of Speech and Language Therapists. FAU - Botes, Mignon AU - Botes M AUID- ORCID: 0000-0003-3796-6901 AD - Department of Speech-Language Pathology, University of the Witwatersrand, Johannesburg, South Africa. FAU - Masuku, Khetsiwe AU - Masuku K AUID- ORCID: 0000-0003-3413-689X AD - Department of Speech-Language Pathology, University of the Witwatersrand, Johannesburg, South Africa. FAU - Mupawose, Anniah AU - Mupawose A AUID- ORCID: 0000-0001-5009-0452 AD - Department of Speech-Language Pathology, University of the Witwatersrand, Johannesburg, South Africa. LA - eng PT - Journal Article PT - Review PT - Scoping Review PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders JID - 9803709 SB - IM MH - Humans MH - Child MH - *Language Development Disorders/diagnosis MH - Multilingualism MH - Psychometrics MH - *Language Tests/standards MH - Child, Preschool MH - Linguistics MH - Reproducibility of Results PMC - PMC13677082 OTO - NOTNLM OT - cultural adaptation OT - diagnostic language assessment OT - linguistic adaptation OT - multilingual children OT - scoping review COIS- The authors declare no conflicts of interest. EDAT- 2026/10/18 17:32 MHDA- 2026/10/18 17:33 PMCR- 2026/10/18 CRDT- 2026/10/18 12:53 PHST- 2026/10/06 00:00 [revised] PHST- 2026/01/16 00:00 [received] PHST- 2026/10/08 00:00 [accepted] PHST- 2026/10/18 17:33 [medline] PHST- 2026/10/18 17:32 [pubmed] PHST- 2026/10/18 12:53 [entrez] PHST- 2026/10/18 00:00 [pmc-release] AID - JLCD70357 [pii] AID - 10.1111/1460-6984.70357 [doi] PST - ppublish SO - Int J Lang Commun Disord. 2026 Nov-Dec;61(6):e70357. doi: 10.1111/1460-6984.70357. PMID- 42893396 OWN - NLM STAT- Publisher LR - 20261018 IS - 1751-8431 (Electronic) IS - 1751-8423 (Linking) DP - 2026 Oct 18 TI - Classroom-based observation and intervention of executive function for special education teachers working with preschoolers with Autism. PG - 1-17 LID - 10.1080/17518423.2026.2750397 [doi] AB - BACKGROUND/OBJECTIVES: Executive function (EF) related behavioral challenges are frequently observed in preschool children with autism spectrum disorder. However, structured, classroom-based observation of these behaviors by teachers remains difficult, resulting in limited practical assessment and recommendations for classroom-based support. This study aimed to examine the feasibility of teacher-administered EF assessment in special education centers and to formulate preliminary, expert-informed recommendations for autistic children with varying communication abilities. METHODS: A mixed-methods sequential design was used. A total of 793 children with autism aged 3-6 years were assessed by trained teachers. Multidisciplinary expert consultation was conducted to formulate preliminary recommendations for classroom activities based on age and communication profiles. RESULTS: Teachers achieved at least 85% accuracy in score conversion and interpretation, supporting the feasibility of its use in a special education classroom. Patterns of EF-related behavioral challenges observed in 793 children aged 3-6 years were integrated with existing evidence and multidisciplinary expert consensus to inform preliminary recommendations for classroom activities. Working memory, inhibitory control, and cognitive flexibility were most evident, especially in children with limited verbal communication and those requiring intensive classroom support. Expert-informed classroom activities, including structured play, rule-changing games, memory-based exercises, emotional reflection tasks, and narrative planning, were subsequently suggested with increasing complexity across age groups and levels of communication ability. CONCLUSIONS: The findings provide preliminary support for the teacher-administered MU.EF-102 of the classroom use and informed age- and communication-responsive, expert-informed classroom activity recommendations. The effectiveness of these recommendations requires evaluation in future intervention studies. FAU - Aonsri, Chanada AU - Aonsri C AD - Centre of Integrative Physical Therapy and Human Movement Sciences (CIPTHM), School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand. FAU - Siritaratiwat, Wantana AU - Siritaratiwat W AD - Centre of Integrative Physical Therapy and Human Movement Sciences (CIPTHM), School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand. FAU - Mongput, Korrawan AU - Mongput K AD - School of Psychology and Human Development, Faculty of Education, Khon Kaen University, Khon Kaen, Thailand. FAU - Mato, Lugkana AU - Mato L AD - Centre of Integrative Physical Therapy and Human Movement Sciences (CIPTHM), School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand. FAU - Chatprem, Thiwaphon AU - Chatprem T AD - Centre of Integrative Physical Therapy and Human Movement Sciences (CIPTHM), School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand. FAU - Vincent, Claude AU - Vincent C AD - Faculty of Medicine, School of Rehabilitation Sciences, Universite Laval, Quebec, QC, Canada. LA - eng PT - Journal Article DEP - 20261018 PL - England TA - Dev Neurorehabil JT - Developmental neurorehabilitation JID - 101304394 SB - IM OTO - NOTNLM OT - Autism spectrum disorder OT - executive function OT - preschool children OT - special education OT - teacher-administered assessment EDAT- 2026/10/18 11:29 MHDA- 2026/10/18 11:29 CRDT- 2026/10/18 07:33 PHST- 2026/10/18 11:29 [medline] PHST- 2026/10/18 11:29 [pubmed] PHST- 2026/10/18 07:33 [entrez] AID - 10.1080/17518423.2026.2750397 [doi] PST - aheadofprint SO - Dev Neurorehabil. 2026 Oct 18:1-17. doi: 10.1080/17518423.2026.2750397. PMID- 42893364 OWN - NLM STAT- Publisher LR - 20261018 IS - 2391-5854 (Electronic) IS - 0033-2674 (Linking) DP - 2026 May 30 TI - PANDAS in the post-COVID era: links to group A Streptococcus and implications for pediatric neuropsychiatry ‒ a narrative review. PG - 1-13 LID - 218782 [pii] LID - 10.12740/PP/OnlineFirst/218782 [doi] AB - Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are defined by the abrupt onset of tics and/or obsessive-compulsive symptoms temporally linked to group A Streptococcus (GAS). Post-pandemic reports note a rebound of pediatric invasive GAS (iGAS), providing an epidemiologic backdrop for more frequent neuropsychiatric presentations. This narrative review (2020-2025; PubMed/MEDLINE, ScienceDirect, Wiley Online Library, MDPI, plus snowballing) synthesizes evidence on the PANDAS/PANS-GAS relationship, clinical spectrum, differential diagnosis with Sydenham chorea (SC), immunopathogenesis, and treatment. Beyond classic OCD and motor tics, the phenotype includes speech disfluency, ocular tics, and acute eating restriction with functional and nutritional risk. Immunologic data support molecular mimicry, Th17/IL-17-driven neuroinflammation, blood‒brain barrier dysfunction, and antineuronal or folate receptor-alpha antibodies; however, no single validated biomarker exists, and antistreptolysin O (ASO), anti-DNase B document exposure only. Management is individualized and multimodal: antibiotic eradication (with prophylaxis in selected, frequently relapsing cases), immunomodulation (steroids, intravenous immunoglobulin (IVIG), therapeutic plasma exchange) for severe/refractory courses, and Cognitive Behavioral Therapy/Selective Serotonin Reuptake Inhibitors (CBT/SSRIs) for core psychiatric symptoms. Contemporary data strengthen a post-streptococcal, immune-mediated framework while underscoring heterogeneous case definitions and the paucity of high-quality trials; prospective biomarker and treatment validation remain priorities. FAU - Kozlak, Julia AU - Kozlak J AD - Student Scientific Circle at the Department of Infectious and Tropical Diseases, Andrzej Frycz Modrzewski Krakow University, Medical College, Krakow, Poland. FAU - Stopyra, Lidia AU - Stopyra L AD - Department of Infectious and Tropical Diseases, Medical College, Andrzej Frycz Modrzewski Krakow University. FAU - Gisel, Marcel AU - Gisel M AD - Student Scientific Circle at the Department of Infectious and Tropical Diseases, Andrzej Frycz Modrzewski Krakow University, Medical College, Krakow, Poland. LA - eng PT - Journal Article PT - Review TT - PANDAS w czasie post COVID-19: zwiazek z zakazeniem paciorkowcami grupy A i implikacje dla neuropsychiatrii dzieciecej - przeglad narracyjny. DEP - 20260530 PL - Poland TA - Psychiatr Pol JT - Psychiatria polska JID - 0103314 SB - IM OTO - NOTNLM OT - Sydenheim chorea OT - obsessive-compulsive disorder OT - tics EDAT- 2026/10/18 11:29 MHDA- 2026/10/18 11:29 CRDT- 2026/10/18 05:34 PHST- 2026/10/18 11:29 [medline] PHST- 2026/10/18 11:29 [pubmed] PHST- 2026/10/18 05:34 [entrez] AID - 218782 [pii] AID - 10.12740/PP/OnlineFirst/218782 [doi] PST - aheadofprint SO - Psychiatr Pol. 2026 May 30:1-13. doi: 10.12740/PP/OnlineFirst/218782. PMID- 42892472 OWN - NLM STAT- Publisher LR - 20261023 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 466 DP - 2026 Oct 17 TI - QTc reference ranges in eastern European children aged 6 to 18 years: a large-scale population study and comparison with international normative datasets. PG - 134990 LID - S0167-5273(26)00840-5 [pii] LID - 10.1016/j.ijcard.2026.134990 [doi] AB - BACKGROUND: QT interval corrected for heart rate (QTc) is important. Appropriate reference ranges support ECG interpretation, but data for Eastern European children remain limited. We aimed to derive age- and sex-stratified QTc reference ranges, estimate proportions exceeding cut-offs, and compare results with normative datasets. METHODS: 12‑lead ECGs from 22,335 children aged 6-18 years were obtained through the CARDIOPED screening programme in northwestern Transylvania, Romania. QTc was calculated using Bazett's formula. Age- and sex-stratified percentile curves (P2.5-P97.5) were derived using spline regression. Correlations with anthropometric variables and proportions exceeding QTc cut-offs of 440, 460, and 480 ms were assessed. Results were compared with the Davignon, Rijnbeek, Saarel, Bratincsak, and Mason datasets. RESULTS: Overall median QTc was 408.2 ms in males and 409.9 ms in females. Upper reference limits (P97.5) were 451.4 ms and 457.0 ms, respectively. The sex difference increased from 2.6 ms in the 6-12-year group to 5.7 ms in the 12-18-year group. Obesity and anthropometric variables showed weak, non-significant correlations with QTc. Values were closely aligned with Rijnbeek et al. QTc exceeded 440 ms in 6.0% of males and 460 ms in 1.2% of females; 14 children (0.06%) had a single screening QTc measurement >/=480 ms. CONCLUSIONS: QTc reference ranges in this Eastern European cohort were consistent with European paediatric normative data. Upper reference limits were approximately 450 ms in males and 460 ms in females. Proportions exceeding cut-offs describe cohort distributions, not diagnostic false-positive rates. Percentiles are statistical reference limits rather than validated clinical decision or diagnostic thresholds. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Cismaru, Gabriel AU - Cismaru G AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Electronic address: gabi_cismaru@yahoo.com. FAU - Lazea, Cecilia AU - Lazea C AD - Department of Pediatrics I, Emergency Clinic Hospital for Children, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Muresan, Lucian AU - Muresan L AD - Cardiology Department, "Emile Muller" Hospital, Mulhouse, 68100, France. FAU - Gusetu, Gabriel AU - Gusetu G AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Rosu, Radu AU - Rosu R AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Pop, Dana AU - Pop D AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Negru, Alina AU - Negru A AD - Department of Cardiology II, University of Medicine and Pharmacy "Victor Babes", Timisoara, 300041, Romania. FAU - Cainap, Simona Sorana AU - Cainap SS AD - Department of Pediatrics II, Emergency Clinic Hospital for Children, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. LA - eng PT - Journal Article DEP - 20261017 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM OTO - NOTNLM OT - Bazett OT - Children OT - Electrocardiography OT - LQTS OT - QTc OT - Screening COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/10/18 05:37 MHDA- 2026/10/18 05:37 CRDT- 2026/10/18 01:48 PHST- 2026/06/29 00:00 [received] PHST- 2026/10/09 00:00 [revised] PHST- 2026/10/11 00:00 [accepted] PHST- 2026/10/18 05:37 [pubmed] PHST- 2026/10/18 05:37 [medline] PHST- 2026/10/18 01:48 [entrez] AID - S0167-5273(26)00840-5 [pii] AID - 10.1016/j.ijcard.2026.134990 [doi] PST - aheadofprint SO - Int J Cardiol. 2026 Oct 17;466:134990. doi: 10.1016/j.ijcard.2026.134990. PMID- 42891355 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Physical education and psychosocial vulnerability in adolescent suicide-related risk: a transnational cross-sectional explainable machine-learning analysis of student health survey data. PG - 1898064 LID - 10.3389/fpsyt.2026.1898064 [doi] LID - 1898064 AB - BACKGROUND: Adolescent suicide attempt is a major public health concern linked to psychosocial distress, school environment, health-risk behaviors, and physical activity patterns. This study aimed to develop an explainable XGBoost model for adolescent suicide-attempt status and to determine whether physical inactivity and low physical education (PE) participation could serve as informative school-based indicators. METHODS: Data were obtained from the Global School-based Student Health Survey conducted in Argentina in 2018, Anguilla in 2016, and Jamaica in 2017. The Argentina dataset was used for model training, while Anguilla and Jamaica were combined as an independent validation cohort. The outcome was self-reported suicide attempt during the past 12 months. Candidate predictors included demographic, anthropometric, dietary, psychosocial, violence- and injury-related, tobacco-related, sexual behavior, physical activity, and PE-related variables. An XGBoost model was developed using nested cross-validation, staged hyperparameter tuning, and Bayesian fine-tuning. Model performance was evaluated by the area under the receiver operating characteristic curve (AUC). SHAP and partial dependence plots were used for interpretation. RESULTS: A total of 27,710 adolescents were included; 5,165 (18.6%) reported at least one suicide attempt. The final model achieved an independent validation AUC of 0.7928 (95% CI: 0.7790-0.8066). The top 18 SHAP-ranked predictors retained a cumulative 10-fold cross-validated AUC of 0.7865. Loneliness was the most influential predictor, followed by sex, insomnia, early cigarette use, PE days, physical attack, school peer kindness, and physical activity. Physical inactivity and low PE participation showed nonlinear associations with predicted suicide-attempt risk. CONCLUSIONS: Loneliness and insomnia represented the psychosocial vulnerability profile, while physical inactivity and limited PE participation emerged as potentially informative school-based indicators requiring further longitudinal investigation. These findings support risk-stratified prevention strategies integrating early psychological identification with inclusive, socially supportive physical activity and PE programs. CI - Copyright (c) 2026 Liu, Guo, Ma, Shi, Ma and Li. FAU - Liu, Heyi AU - Liu H AD - Tianjin College, University of Science and Technology Beijing, Tianjin, China. FAU - Guo, Jianbin AU - Guo J AD - Quality Control Office, Kailuan Mental Health Center, Tangshan, China. FAU - Ma, Xinwei AU - Ma X AD - Department of Radiology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. FAU - Shi, Cheng AU - Shi C AD - Department of Cardiology, Suzhou BenQ Medical Center, Suzhou, China. FAU - Ma, Xiaoming AU - Ma X AD - Department of Cardiology, Suzhou BenQ Medical Center, Suzhou, China. AD - Department of Neurology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. AD - Department of Neurology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China. AD - Suzhou Key Laboratory of Integrated Stroke Prevention, Treatment and Rehabilitation, Suzhou, China. FAU - Li, Jingwei AU - Li J AD - Department of Neurology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. AD - Department of Neurology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China. AD - Suzhou Key Laboratory of Integrated Stroke Prevention, Treatment and Rehabilitation, Suzhou, China. AD - Suzhou Research Centre of Medical School, Nanjing University, Suzhou, China. AD - Institute of Brain Sciences, Nanjing University, Nanjing, China. AD - Nanjing Neurology Clinic Medical Center, Nanjing, China. LA - eng PT - Journal Article DEP - 20261002 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13674449 OTO - NOTNLM OT - adolescent OT - machine learning OT - mental health OT - physical education and training OT - suicide COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:38 MHDA- 2026/10/17 23:39 PMCR- 2026/10/02 CRDT- 2026/10/17 21:49 PHST- 2026/06/04 00:00 [received] PHST- 2026/09/05 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/17 23:39 [medline] PHST- 2026/10/17 23:38 [pubmed] PHST- 2026/10/17 21:49 [entrez] PHST- 2026/10/02 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1898064 [doi] PST - epublish SO - Front Psychiatry. 2026 Oct 2;17:1898064. doi: 10.3389/fpsyt.2026.1898064. eCollection 2026. PMID- 42891011 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 2589-5370 (Electronic) IS - 2589-5370 (Linking) VI - 100 DP - 2026 Oct TI - Interdisciplinary intervention (GAIN) vs. enhanced usual care for reducing severe post-concussion symptoms in adults 2-4 months post-injury: a stepped wedge cluster randomised controlled trial. PG - 104243 LID - 10.1016/j.eclinm.2026.104243 [doi] LID - 104243 AB - BACKGROUND: Up to 30% of adults presenting to emergency departments develop persisting post-concussion symptoms (PPCS). Get going After concussIoN (GAIN), has previously shown promising effects in reducing PPCS in adolescents and young adults. METHODS: This stepped wedge cluster randomised trial tested the effect of GAIN in reducing high levels of PPCS (i.e. a score >/=20 on the Rivermead Post-concussion Symptoms Questionnaire (RPQ)) 2-4 months post-injury in adults (18-60 years). GAIN was delivered in five clusters of municipalities in the Central Denmark Region sequentially allocated to implement the intervention, with one cluster transitioning to deliver GAIN every 3 months over six recruitment periods in the order of a computer-generated randomisation schedule. Participants were allocated to enhanced usual care (EUC) or GAIN + EUC depending on time and their place of residence. Masking of participants and therapists was not feasible. Primary outcome was change in RPQ total score from baseline to 3-month follow-up. Analyses were based on intention to treat using linear-mixed models. The trial is registered with ClinicalTrials.gov, NCT04798885. FINDINGS: Between May 1, 2021 and November 1, 2022, 310 participants were included. The average difference in change in RPQ score between GAIN + EUC (n = 170) and EUC (n = 140) from baseline to 3-month follow-up was -2.4 points (95% CI -5.4 to 0.4, p = 0.09) in the adjusted model. GAIN reduced maladaptive, symptom-related perceptions and behaviours and patient satisfaction was high. GAIN + EUC was not associated with a greater improvement in psychological distress or physical and mental health than EUC. No serious adverse events were reported. INTERPRETATION: This study could not confirm the hypothesis that GAIN added to EUC led to a larger long-term reduction in PPCS than EUC alone in adults. However, GAIN may improve long-term prognosis by reducing maladaptive, symptom-related perceptions and behaviours. FUNDING: The foundation Sygeforsikringen "danmark" and Central Denmark Region. CI - (c) 2026 The Author(s). FAU - Hellemose, Line Amalie AU - Hellemose LA AD - Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University, Aarhus, Denmark. FAU - Thastum, Mille Moller AU - Thastum MM AD - Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University, Aarhus, Denmark. FAU - Stabel, Henriette Holm AU - Stabel HH AD - Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University, Aarhus, Denmark. FAU - Odgaard, Lene AU - Odgaard L AD - Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University, Aarhus, Denmark. FAU - Rask, Charlotte Ulrikka AU - Rask CU AD - Department of Child and Adolescent Psychiatry, Aarhus University Hospital, Aarhus N, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark. FAU - Silverberg, Noah D AU - Silverberg ND AD - Department of Psychology, University of British Columbia, Vancouver, BC, Canada. AD - Rehabilitation Research Program, Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. AD - Member, Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada. FAU - Skandsen, Toril AU - Skandsen T AD - Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. AD - Clinic of Rehabilitation, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway. FAU - Rytter, Hana Mala AU - Rytter HM AD - The Danish Concussion Center, Copenhagen, Denmark. AD - Department of Neurology, University Hospital Bispebjerg - Frederiksberg, Copenhagen, Denmark. AD - Department of Psychology, University of Copenhagen, Copenhagen, Denmark. FAU - Nygaard, Charlotte AU - Nygaard C AD - Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University, Aarhus, Denmark. FAU - Eggertsen, Peter Preben AU - Eggertsen PP AD - Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark. FAU - Pedersen, Carsten B AU - Pedersen CB AD - Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University, Aarhus, Denmark. AD - National Centre for Register-Based Research, Aarhus University, Aarhus V, Denmark. FAU - Nielsen, Jorgen Feldbaek AU - Nielsen JF AD - Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University, Aarhus, Denmark. LA - eng SI - ClinicalTrials.gov/NCT04798885 PT - Journal Article DEP - 20260922 PL - England TA - EClinicalMedicine JT - EClinicalMedicine JID - 101733727 PMC - PMC13672966 OTO - NOTNLM OT - Brain concussion OT - Cognitive behavioural therapy OT - Graded exercise therapy OT - Illness perceptions OT - Intervention OT - Mild traumatic brain injury COIS- LAH, MMT, HHS and LO received grants from Sygeforsikringen "danmark" during the conduct of the study. Payment was made to Hammel Neurorehabilitation and Research Centre. Central Denmark Region Provided financial support to the outpatient clinic at Hammel Neurorehabilitation Centre. All other authors received no support for the present manuscript. In the past 36 months, CUR has received grants from the Independent Research Fund Denmark, Aage and Johanne Louis-Hansen Foundation, Tryg Foundation, The Psychiatric Research Foundation, Central Denmark Region, Lundbeck Foundation and Central Denmark Region Research Fund, and royalties from the publisher Gyldendal A/S. In addition, CUR is an Advisory Board Member for the German trial: iSOMA+, and a board member of European Association for Psychosomatic Medicine (EAPM). CUR has received payment for expert testimony from the Einstein Foundation Berlin, the Independent Research Fund Denmark (DFF), the Trondheim Mohn Research Foundation, the Icelandic Research Fund, the Australian National Health and Medical Research Council (NHMRC), and the Irish Research Council. In the past 36 months, NDS declare that his institution has received research grants or contracts from CIHR, Mitacs, Canada Foundation for Innovation, WorkSafeBC and VGH + UBC hospital foundation. NDS declares that a collaborator's institution has received research grants or contracts from Ontario Brain Institute and DoD. NDS (Dr. Noah Silverberg Inc) has received consulting fees for clinical and medical-legal consulting. Furthermore, NDS has received honorarium for lectures at Canadian Society of Medical Evaluators, WorkSafeBC, Yukon Workers' Compensation Health and Safety Board, Worker's Compensation Board of Alberta, NYU-Langone, International Academy of Independent Medical Examiners, and University of Calgary. CBP, CN, HMR, PPE, and TS declare no relationships/activities/interests related to the content of this manuscript. EDAT- 2026/10/17 23:38 MHDA- 2026/10/17 23:39 PMCR- 2026/09/22 CRDT- 2026/10/17 20:46 PHST- 2026/03/24 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/17 23:39 [medline] PHST- 2026/10/17 23:38 [pubmed] PHST- 2026/10/17 20:46 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - S2589-5370(26)00496-7 [pii] AID - 104243 [pii] AID - 10.1016/j.eclinm.2026.104243 [doi] PST - epublish SO - EClinicalMedicine. 2026 Sep 22;100:104243. doi: 10.1016/j.eclinm.2026.104243. eCollection 2026 Oct. PMID- 42891007 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 2772-3682 (Electronic) IS - 2772-3682 (Linking) VI - 55 DP - 2026 Dec TI - Effects of prenatal early food and micronutrient supplementations on body size and cardiometabolic risk factors in the 15-year-old offspring - the MINIMat randomised trial. PG - 100878 LID - 10.1016/j.lansea.2026.100878 [doi] LID - 100878 AB - BACKGROUND: Evidence on the effects of maternal nutrition during pregnancy on offspring cardiometabolic risk is mixed. We hypothesized that 15-year-olds, whose mothers were randomised to maternal early pregnancy protein-energy supplementation, are taller and have lower low-density lipoprotein cholesterol than controls. We also assessed effects of prenatal multiple micronutrient supplementation (MMS) on adolescent body size and cardiometabolic risk factors. METHODS: In MINIMat trial (Maternal and Infant Nutrition Interventions in Matlab; ISRCTN16581394) in rural Bangladesh, pregnant women were randomised in a 2:3 factorial design to early invitation to food supplementation (around gestational week 9), vs standard programme (usual invitation); MMS was compared with folic acid and iron. Of 3267 singletons with valid birth weight, 2300 (70.4%) were measured height and weight, plasma cardiometabolic biomarkers and blood pressure at 15 years, between September 2017 and June 2019. We analysed data by linear and logistic regression, adjusting for sex, age and prenatal confounders. FINDINGS: Adolescents whose mothers received early invitation had 0.08 units higher height z score (95% CI 0.01, 0.16) and less of them were stunted (<-2 SD; 17.4% vs 21.4%, risk difference 4.1%; 95% CI 0.8%, 7.3%; OR 0.77; 0.63, 0.95) than usual invitation group. Early invitation and MMS were unrelated to BMI, plasma cardiometabolic biomarkers or blood pressure. INTERPRETATION: The effect of early prenatal food supplementation on height persists at 15 years. We found no effect of this intervention or MMS on cardiometabolic factors. FUNDING: Swedish Research Council, Finnish Research Council, Finska Lakaresallskapet, Pediatric Research, Novo Nordisk, Gyllenberg and Juselius Foundations. CI - (c) 2026 The Author(s). FAU - Kajantie, Eero AU - Kajantie E AD - Clinical Medicine Research Unit, MRC Oulu, University of Oulu and Oulu University Hospital, PL 9000, 90014, Oulun yliopisto, Oulu, Finland. AD - Welfare Epidemiology and Monitoring Unit, Finnish Institute for Health and Welfare, PL 30, 00271, Helsinki, Finland. FAU - Raqib, Rubhana AU - Raqib R AD - International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), GPO Box 128, Dhaka, 1000, Bangladesh. FAU - Ekstrom, Eva-Charlotte AU - Ekstrom EC AD - Department of Women's and Children's Health, Global Health and Migration Unit, Uppsala University, Akademiska sjukhuset, SE-751 85, Uppsala, Sweden. FAU - Rahman, Monjur AU - Rahman M AD - International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), GPO Box 128, Dhaka, 1000, Bangladesh. FAU - Nasanen-Gilmore, Pieta AU - Nasanen-Gilmore P AD - Data Operations Management Team, Finnish Institute for Health and Welfare, PL 30, 00271, Helsinki, Finland. FAU - Rahman, Syed Moshfiqur AU - Rahman SM AD - Department of Women's and Children's Health, Global Health and Migration Unit, Uppsala University, Akademiska sjukhuset, SE-751 85, Uppsala, Sweden. FAU - Pervin, Jesmin AU - Pervin J AD - International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), GPO Box 128, Dhaka, 1000, Bangladesh. FAU - Islam, Mohammad Redwanul AU - Islam MR AD - Department of Women's and Children's Health, Global Health and Migration Unit, Uppsala University, Akademiska sjukhuset, SE-751 85, Uppsala, Sweden. AD - Institute of Environmental Medicine, Karolinska Institutet, SE-17177, Stockholm, Sweden. FAU - El Arifeen, Shams AU - El Arifeen S AD - International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), GPO Box 128, Dhaka, 1000, Bangladesh. FAU - Kippler, Maria AU - Kippler M AD - Institute of Environmental Medicine, Karolinska Institutet, SE-17177, Stockholm, Sweden. FAU - Rahman, Anisur AU - Rahman A AD - International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), GPO Box 128, Dhaka, 1000, Bangladesh. AD - Department of Women's and Children's Health, Global Health and Migration Unit, Uppsala University, Akademiska sjukhuset, SE-751 85, Uppsala, Sweden. LA - eng PT - Journal Article DEP - 20261005 PL - England TA - Lancet Reg Health Southeast Asia JT - The Lancet regional health. Southeast Asia JID - 9918419282806676 PMC - PMC13672831 OTO - NOTNLM OT - Cardiometabolic OT - Cardiovascular OT - Energy OT - Pregnancy OT - Pregnant OT - Protein COIS- EK has been supported by Research Council of Finland, Finska Lakaresallskapet, Foundation for Pediatric Research, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation and Sigrid Juselius Foundation for the present manuscript and in addition European Commission for other work. SEA Has been supported by Swedish Research Council for the present manuscript. Other authors report no conflict of interest. EDAT- 2026/10/17 23:38 MHDA- 2026/10/17 23:39 PMCR- 2026/10/05 CRDT- 2026/10/17 20:46 PHST- 2025/11/10 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/17 23:39 [medline] PHST- 2026/10/17 23:38 [pubmed] PHST- 2026/10/17 20:46 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - S2772-3682(26)00163-0 [pii] AID - 100878 [pii] AID - 10.1016/j.lansea.2026.100878 [doi] PST - epublish SO - Lancet Reg Health Southeast Asia. 2026 Oct 5;55:100878. doi: 10.1016/j.lansea.2026.100878. eCollection 2026 Dec. PMID- 42890200 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 2768-2765 (Electronic) IS - 2768-2765 (Linking) VI - 17 DP - 2026 Nov TI - Menstrual Cycle Phase-Dependent Lower Extremity Loading Patterns in Adolescent Female Athletes: Implications for Anterior Cruciate Ligament Injury Risk. PG - 100434 LID - 10.1016/j.jposna.2026.100434 [doi] LID - 100434 AB - BACKGROUND: Physically active females experience substantially higher anterior cruciate ligament injury rates than males, and postmenarche adolescent females commonly demonstrate high-risk mechanics. However, whether mechanics fluctuate across the menstrual cycle remains poorly understood in adolescent female athletes. The aim of this study was to examine differences in lower extremity kinematics and kinetics across two menstrual cycle phases (menstruation and mid-luteal) in postmenarchal adolescent female athletes during a dynamic change-of-direction task. It was hypothesized that biomechanical contributors to dynamic knee valgus would differ between phases. METHODS: A controlled laboratory study was conducted. Thirty healthy postmenarchal adolescent female athletes (aged 13-17 years) were tested during menstruation (verified by self-reported active bleeding) and mid-luteal phase (scheduled via calendar-based day counting). Kinematics and kinetics were collected using 3-dimensional motion capture and force plates while participants performed a 45 degrees run-cut task. Peak pelvis, hip, and knee angles and hip and knee moments were extracted during the loading phase for each limb. Linear mixed-effects models tested effects of phase and limb dominance (alpha = 0.05). RESULTS: Participants were aged 15.6 +/- 0.9 years, had a height of 168.8 +/- 6.2 cm, and weighed 61.2 +/- 7.0 kg, and a majority played soccer (70.0%). Compared with menstruation, the mid-luteal phase demonstrated greater peak anterior pelvic tilt (P = .018) and pelvic rise (P = .038), along with reduced peak knee flexion (P = .009). During menstruation, athletes exhibited greater hip abduction moment (P = .037), hip internal rotation moment (P = .043), knee valgus moment (P = .012), and knee external rotation moment (P = .007). Limb dominance effects were observed for pelvic rise (P < .001) and hip internal rotation moment (P = .047). CONCLUSIONS: Biomechanical contributors linked to dynamic knee valgus differed by menstrual cycle phase in adolescent female athletes during a change-of-direction task. Menstruation was associated with greater coronal- and transverse-plane hip and knee loading, whereas mid-luteal phase was associated with reduced knee flexion and greater pelvic instability. Cycle-synced injury prevention strategies that are individualized and evidence-based may enhance lower extremity stability when knee control appears most challenged. However, while cycle-synced training may not be feasible in all settings, awareness of phase-related vulnerability may inform screening and load management. KEY CONCEPTS: (1)Menstrual cycle phase may contribute to variability in lower extremity biomechanics during change-of-direction tasks in adolescent female athletes.(2)Biomechanical risk factors associated with dynamic knee valgus may differ between menstruation and mid-luteal phases.(3)Consideration of menstrual cycle phase may improve interpretation of biomechanical screening and performance testing.(4)Individualized injury prevention strategies may benefit from awareness of phase-related biomechanical changes. LEVEL OF EVIDENCE: III. CI - (c) 2026 The Author(s). FAU - Ulman, Sophia AU - Ulman S AD - Movement Science, Scottish Rite for Children, Frisco, TX, USA. AD - Orthopaedic Surgery, University of Texas Southwestern, Dallas, TX, USA. FAU - Garcia, Jessica AU - Garcia J AD - Movement Science, Scottish Rite for Children, Frisco, TX, USA. FAU - Jones, Jacob AU - Jones J AD - Movement Science, Scottish Rite for Children, Frisco, TX, USA. AD - Orthopaedic Surgery, University of Texas Southwestern, Dallas, TX, USA. FAU - Davis, Ava AU - Davis A AD - Movement Science, Scottish Rite for Children, Frisco, TX, USA. FAU - Erdman, Ashley AU - Erdman A AD - Movement Science, Scottish Rite for Children, Frisco, TX, USA. FAU - Wilson, Philip AU - Wilson P AD - Movement Science, Scottish Rite for Children, Frisco, TX, USA. AD - Orthopaedic Surgery, University of Texas Southwestern, Dallas, TX, USA. FAU - Ellis, Henry AU - Ellis H AD - Movement Science, Scottish Rite for Children, Frisco, TX, USA. AD - Orthopaedic Surgery, University of Texas Southwestern, Dallas, TX, USA. LA - eng PT - Journal Article DEP - 20260808 PL - United States TA - J Pediatr Soc North Am JT - Journal of the Pediatric Orthopaedic Society of North America JID - 101776896 PMC - PMC13671034 OTO - NOTNLM OT - Adolescent athletes OT - Anterior cruciate ligament OT - Biomechanics OT - Dynamic knee valgus OT - Menstrual cycle COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/08/08 CRDT- 2026/10/17 14:54 PHST- 2026/06/04 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 14:54 [entrez] PHST- 2026/08/08 00:00 [pmc-release] AID - S2768-2765(26)00113-6 [pii] AID - 100434 [pii] AID - 10.1016/j.jposna.2026.100434 [doi] PST - epublish SO - J Pediatr Soc North Am. 2026 Aug 8;17:100434. doi: 10.1016/j.jposna.2026.100434. eCollection 2026 Nov. PMID- 42889669 OWN - NLM STAT- MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - The microbiome-metabolite-vaccine axis: context-dependent modulators of immunogenicity and durability. PG - 1972642 LID - 10.3389/fimmu.2026.1972642 [doi] LID - 1972642 AB - Vaccine responses vary markedly between individuals, yet age, genetics, prior antigen exposure, comorbidity, nutrition and vaccine platform explain only part of this heterogeneity. The intestinal microbiome is a candidate modulator through microbial metabolites and parallel non-metabolic signals. Human studies link microbial features to vaccine outcomes, but taxa rarely replicate across geography, age and platform. Small randomised antibiotic studies identify effects of treatment assignment, not necessarily microbiome mediation; infant microbial rescue has been demonstrated in mice rather than infants. Amongst the pathways considered, short-chain fatty acids have the largest mechanistic evidence base, predominantly preclinical, but acetate, propionate and butyrate differ in targets, exposure and direction of effect, and direct human vaccine mediation remains unestablished. Null findings for BNT162b2 in microbiota-depleted mice and for overall antibody responses in an older-adult probiotic trial argue against universal microbiome dependence or probiotic benefit. We organise the evidence around a microbial function-mediator-exposure-immune-checkpoint-endpoint chain, retaining a primary focus on metabolites. Vaccine take, peak antibody, decay and recall are distinguished from clinical protection. We also separate microbiome-modifying probiotics from antigen-delivery platforms. A decision-gated workflow links signature discovery, source and target verification, independent validation, randomised intervention and demonstrated clinical utility. Microbiome-guided vaccination remains a research strategy rather than an established clinical practice. CI - Copyright (c) 2026 Sun, Yang, Lv, Yu and Si. FAU - Sun, Ge AU - Sun G AD - Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China. FAU - Yang, Jingyi AU - Yang J AD - Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China. FAU - Lv, Suzhen AU - Lv S AD - Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China. FAU - Yu, Lijie AU - Yu L AD - Department of Obstetrics and Gynecology, Lishu County Traditional Chinese Medicine Hospital, Siping, China. FAU - Si, Lihui AU - Si L AD - Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China. LA - eng PT - Journal Article PT - Review DEP - 20261001 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Vaccines) SB - IM MH - Humans MH - Animals MH - *Gastrointestinal Microbiome/immunology MH - *Immunogenicity, Vaccine MH - *Vaccines/immunology MH - Probiotics MH - Vaccination PMC - PMC13669876 OTO - NOTNLM OT - antibody durability OT - gut microbiome OT - immune memory OT - immunometabolism OT - microbial metabolites OT - precision vaccination OT - systems vaccinology OT - vaccine immunogenicity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 12:00 PHST- 2026/08/19 00:00 [received] PHST- 2026/09/10 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 12:00 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1972642 [doi] PST - epublish SO - Front Immunol. 2026 Oct 1;17:1972642. doi: 10.3389/fimmu.2026.1972642. eCollection 2026. PMID- 42889450 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1976-1457 (Print) IS - 2005-6168 (Electronic) IS - 1976-1457 (Linking) VI - 20 IP - 5 DP - 2026 Oct TI - Comparability of food frequency questionnaires between Korean Children's Environmental Health Study (Ko-CHENS) and Korean Genome and Epidemiology Study (KoGES) in pregnant women. PG - 866-878 LID - 10.4162/nrp.2026.20.5.866 [doi] AB - BACKGROUND/OBJECTIVES: The Korean Children's Environmental Health Study (Ko-CHENS) developed a food frequency questionnaire (FFQ) to assess maternal dietary intake during pregnancy. This FFQ shares high structural similarity with the validated FFQ of the Korean Genome and Epidemiology Study (KoGES), a representative dietary assessment tool for the Korean adult population, which includes 97 of the 112 items in the Ko-CHENS FFQ. The comparability of the Ko-CHENS and KoGES FFQs among pregnant women was evaluated. SUBJECTS/METHODS: Ninety-four women recruited from Kangwon National University Hospital between December 2024 and February 2025 were included. The participants consecutively completed the Ko-CHENS and KoGES FFQs. The nutrient intakes were adjusted for the total energy intake using the residual method. Log-transformed intakes of energy, nutrients, and food groups were compared using the correlation coefficients, cross-classification percent agreement, weighted kappa statistics, and Bland-Altman plots. RESULTS: The Ko-CHENS FFQ yielded higher absolute intake estimates for energy and the majority of nutrients and food groups than the KoGES FFQ. The Pearson or Spearman correlation coefficients ranged from 0.34 (vitamin E) to 0.68 (beta-carotene) for energy and nutrients and from 0.15 (sugars and jams) to 0.77 (salted vegetables) for food groups, with median values of 0.55 and 0.61, respectively. The median proportions of the participants classified into the same or adjacent quartiles were 96.39% for energy and nutrients and 96.52% for food groups. The weighted kappa statistics ranged from 0.23 to 0.52 for energy and nutrients and from 0.06 to 0.59 for food groups, with median values of 0.38 and 0.45, respectively. The Bland-Altman plots for energy and macronutrients showed that the data points were primarily within the limits of agreement. CONCLUSION: The Ko-CHENS and KoGES FFQs showed fair-to-moderate comparability, suggesting that the Ko-CHENS FFQ can be used for ranking Korean pregnant women based on their dietary intake levels. CI - (c)2026 The Korean Nutrition Society and the Korean Society of Community Nutrition. FAU - Cho, Minsu AU - Cho M AUID- ORCID: 0009-0007-8243-1750 AD - Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea. FAU - Kim, Bom AU - Kim B AUID- ORCID: 0000-0001-9405-2407 AD - Department of Medical Informatics, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Kim, Hyesook AU - Kim H AUID- ORCID: 0000-0002-4840-3082 AD - Department of Food and Nutrition, Wonkwang University, Iksan 54538, Korea. FAU - Na, Sunghun AU - Na S AUID- ORCID: 0000-0002-2803-8356 AD - Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Lee, Se Jin AU - Lee SJ AUID- ORCID: 0000-0002-8626-6250 AD - Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Ahn, Tae Gyu AU - Ahn TG AUID- ORCID: 0000-0002-5519-0572 AD - Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Son, Kyung Ho AU - Son KH AUID- ORCID: 0000-0002-2466-8334 AD - Department of AI Convergence, Kangwon National University, Chuncheon 24341, Korea. FAU - Kim, Woo Jin AU - Kim WJ AUID- ORCID: 0000-0003-2927-370X AD - Department of Medical Informatics, Kangwon National University School of Medicine, Chuncheon 24341, Korea. AD - Department of Internal Medicine and Environmental Health Center, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Lee, Jung Eun AU - Lee JE AUID- ORCID: 0000-0003-1141-878X AD - Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea. AD - Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea. CN - Ko-CHENS Study Group LA - eng PT - Journal Article DEP - 20260918 PL - Korea (South) TA - Nutr Res Pract JT - Nutrition research and practice JID - 101311052 PMC - PMC13669475 OTO - NOTNLM OT - Diet surveys OT - comparative study OT - nutrition assessment OT - pregnancy COIS- Conflict of Interest: The authors declare no potential conflicts of interests. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 11:09 PHST- 2026/04/18 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 11:09 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.4162/nrp.2026.20.5.866 [doi] PST - ppublish SO - Nutr Res Pract. 2026 Oct;20(5):866-878. doi: 10.4162/nrp.2026.20.5.866. Epub 2026 Sep 18. PMID- 42889402 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Association between discretionary screen time and depressive symptoms in Chinese adolescents: a cross-sectional study. PG - 1957282 LID - 10.3389/fped.2026.1957282 [doi] LID - 1957282 AB - BACKGROUND: Adolescents globally exhibit growing engagement with discretionary screen time, but its association with depressive symptoms remains unclear in developing economies. OBJECTIVE: To examine the relationship between discretionary screen time and depressive symptoms among Chinese adolescents. METHODS: A cross-sectional study of 4,706 adolescents in Maoming City, Guangdong Province, China. Participants were stratified into four discretionary screen time categories: <1 h (n = 1,372), 1-2 h (n = 1,277), 2-4 h (n = 1,032), and >/=4 h (n = 1,025). Depressive symptoms were assessed using the validated CESD-9, with a cutoff score of >/=10. The primary analysis was a multilevel logistic regression model with random intercepts for school and class, adjusted for all measured covariates except BMI, anxiety and insomnia; a model additionally adjusted for BMI, anxiety and insomnia served as a sensitivity analysis. Subgroup analyses evaluated potential effect modification. RESULTS: The prevalence of depressive symptoms was 29.7% (1,398/4,706). In the primary multilevel model (random intercepts for school and class; adjusted for sociodemographic, socioeconomic and lifestyle factors, without BMI, anxiety and insomnia), compared with the <1 h reference group, the odds ratios were 1.21 (95% CI: 0.98-1.49; p = 0.082) for 1-2 h, 1.88 (95% CI: 1.52-2.33; p < 0.001) for 2-4 h, and 2.54 (95% CI: 2.04-3.16; p < 0.001) for >/=4 h; each screen-time category increment was associated with 39% higher odds of depressive symptoms (OR = 1.39, 95% CI: 1.29-1.49; p < 0.001). When additionally adjusted for BMI, anxiety and insomnia (sensitivity analysis, Model 4), the associations were attenuated but remained statistically significant for the higher categories (>/=4 h: OR = 1.69, 95% CI: 1.28-2.22; per-category OR = 1.19, 95% CI: 1.09-1.29). Subgroup analyses revealed no statistically significant evidence of effect modification (all p-interaction >0.05). CONCLUSION: Prolonged discretionary screen time is significantly associated with higher odds of depressive symptoms among Chinese adolescents, indicating a graded association that strengthens with increasing screen time. These findings are relevant to public-health monitoring of discretionary screen use in adolescents. CI - (c) 2026 Xu, Yang, Wang and Wang. FAU - Xu, Zhi AU - Xu Z AD - Department of Neurosis and Psychosomatic Diseases, The Third Hospital of Quzhou, Quzhou, Zhejiang, China. FAU - Yang, Shuye AU - Yang S AD - Department of Neurology, Binzhou People's Hospital, Binzhou, Shandong, China. FAU - Wang, Shibin AU - Wang S AD - Guangdong Mental Health Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China. FAU - Wang, Xing AU - Wang X AD - Department of Neurosis and Psychosomatic Diseases, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou Normal University, Huzhou, Zhejiang, China. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13669189 OTO - NOTNLM OT - Chinese adolescents OT - adolescents OT - cross-sectional study OT - depressive symptoms OT - discretionary screen time COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 10:56 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 10:56 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fped.2026.1957282 [doi] PST - epublish SO - Front Pediatr. 2026 Oct 1;14:1957282. doi: 10.3389/fped.2026.1957282. eCollection 2026. PMID- 42889302 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Team sport as a potential context for interpersonal emotion regulation in early adolescence: a quasi-experimental comparison with individual exercise. PG - 1948213 LID - 10.3389/fpsyt.2026.1948213 [doi] LID - 1948213 AB - OBJECTIVE: Emotion regulation deficits are a transdiagnostic risk factor for adolescent emotional disorders. This quasi-experimental study examined whether different exercise contexts were associated with intrapersonal and interpersonal emotion regulation in early adolescents. METHODS: A quasi-experimental cluster-allocated design was conducted with 114 sixth-grade students from three intact classes, with each class allocated to one of three conditions: team exercise, individual exercise, or control condition. Participants completed measures of emotion regulation at pre-test, mid-test, and post-test during an 8-week intervention. RESULTS: Team exercise was associated with a significantly different trajectory of interpersonal emotion regulation over time compared with individual exercise and control conditions, with the team exercise group showing a more favorable pattern of change. Changes in expressive suppression showed a small negative association with changes in interpersonal emotion regulation. CONCLUSION: Team-based cooperative exercise may provide a potentially relevant context for supporting interpersonal emotion regulation in early adolescents, although the association involving expressive suppression should be interpreted cautiously given the low reliability of this subscale. CI - Copyright (c) 2026 Li, You, Tao, Yang and Yu. FAU - Li, Xilin AU - Li X AD - School of Sport Training, Chengdu Sport University, Chengdu, China. FAU - You, Qiuping AU - You Q AD - School of Sport Training, Chengdu Sport University, Chengdu, China. FAU - Tao, Yunfei AU - Tao Y AD - School of Sport Training, Chengdu Sport University, Chengdu, China. FAU - Yang, Chengbo AU - Yang C AD - School of Sport Training, Chengdu Sport University, Chengdu, China. FAU - Yu, Dawei AU - Yu D AD - School of Teacher Education (Physical Education), Taizhou University, Taizhou, China. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13668848 OTO - NOTNLM OT - cognitive reappraisal OT - early adolescents OT - expressive suppression OT - individual exercise OT - interpersonal emotion regulation OT - team exercise COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 09:59 PHST- 2026/07/25 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/20 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 09:59 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1948213 [doi] PST - epublish SO - Front Psychiatry. 2026 Oct 1;17:1948213. doi: 10.3389/fpsyt.2026.1948213. eCollection 2026. PMID- 42889239 OWN - NLM STAT- MEDLINE DCOM- 20261017 LR - 20261019 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Regional differences in obesity risk, sedentary behavior, and dietary patterns among university students in Saudi Arabia: a multi-region cross-sectional study. PG - 1980253 LID - 10.3389/fpubh.2026.1980253 [doi] LID - 1980253 AB - BACKGROUND: Overweight and obesity are rising among Saudi university students. Guided by Popkin's nutrition transition theory, this study examined regional variation in overweight/obesity, sedentary behavior, and nutrition-transition dietary patterns. METHODS: This cross-sectional study (March-May 2023) recruited 564 students from four Saudi administrative regions using a multistage sampling approach. Three colleges per university were selected across three academic domains; within each college, one male and one female class per academic level were invited; all eligible students completed the questionnaire. Students with prior type 2 diabetes were excluded. BMI was calculated from self-reported weight and height (overweight/obesity: >/= 25.0 kg/m(2)). Dietary patterns were identified using principal-component analysis of 17 food groups from a validated 66-item food frequency questionnaire. Physical activity was assessed via IPAQ-SF (sufficient: >/= 150 min/week); composite sedentary behavior exposure was classified as low (< 8 h/day), moderate (8-12 h/day), or high (> 12 h/day). Logistic regression adjusted for sex, age, income, college type, region, and smoking. RESULTS: Overweight/obesity prevalence was 17.9% (n = 100/558); as BMI relied on self-reported anthropometrics, this is a conservative lower bound. A marked regional gradient was observed: 27.8% of Riyadh students were overweight/obese versus 8.8% in Makkah (chi (2) = 25.48, p < 0.001). Region showed the strongest association with overweight/obesity after adjustment: Riyadh (aOR = 4.62, 95% CI 2.23-9.59, p < 0.001) and male sex (aOR = 1.96, 95% CI 1.04-3.71, p = 0.037) were the only significant predictors. Composite sedentary behavior exposure was high: 82.3% were moderately or highly sedentary (>/= 8 h/day), dominated by mobile phone use (3.75 h/day) and academic study (3.35 h/day). Sedentary behavior was higher in overweight/obese students (15.5 vs. 13.9 h/day; p = 0.043). Nutrition-transition dietary patterns were not associated with overweight/obesity (aOR = 0.93, p = 0.543). CONCLUSION: Region showed the strongest association with overweight/obesity, with Riyadh students at four-fold higher risk than Makkah students, suggesting that regional structural and environmental factors may contribute to obesity risk in this population. Prolonged mobile phone use and screen-based sedentarism were prevalent and associated with overweight/obesity. Campus interventions targeting sedentary screen behavior and regional food environments, particularly in Riyadh, are warranted; future studies should employ direct anthropometry to obtain unbiased prevalence estimates. CI - Copyright (c) 2026 Alkhraiji and Alaqil. FAU - Alkhraiji, Mohummed H AU - Alkhraiji MH AD - Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh, Saudi Arabia. FAU - Alaqil, Abdulrahman I AU - Alaqil AI AD - College of Education, Department of Physical Education, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Male MH - Cross-Sectional Studies MH - Female MH - *Sedentary Behavior MH - *Obesity/epidemiology MH - *Students/statistics & numerical data MH - Universities MH - Young Adult MH - *Diet/statistics & numerical data MH - Prevalence MH - Risk Factors MH - Adult MH - *Feeding Behavior MH - Surveys and Questionnaires MH - Overweight/epidemiology MH - Body Mass Index MH - Exercise MH - Adolescent PMC - PMC13668806 OTO - NOTNLM OT - Saudi Arabia OT - dietary patterns OT - nutrition transition OT - obesity OT - overweight OT - regional variation OT - sedentary behavior OT - self-reported BMI COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:13 MHDA- 2026/10/17 23:14 PMCR- 2026/10/01 CRDT- 2026/10/17 09:27 PHST- 2026/08/27 00:00 [received] PHST- 2026/09/18 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/17 23:14 [medline] PHST- 2026/10/17 23:13 [pubmed] PHST- 2026/10/17 09:27 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1980253 [doi] PST - epublish SO - Front Public Health. 2026 Oct 1;14:1980253. doi: 10.3389/fpubh.2026.1980253. eCollection 2026. PMID- 42889191 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Does learning burnout link physical exercise and problematic short-video use? Evidence from a three-wave random-intercept cross-lagged panel model and supplementary machine-learning analysis among Chinese high school students. PG - 1929181 LID - 10.3389/fpsyg.2026.1929181 [doi] LID - 1929181 AB - BACKGROUND: Problematic short-video use has become a growing behavioral health concern among adolescents, yet its longitudinal links with physical exercise and learning burnout remain insufficiently understood. This study examined the within-person bidirectional associations among physical exercise, learning burnout, and problematic short-video use, tested whether learning burnout served as a longitudinal pathway linking physical exercise to later problematic short-video use, and explored the predictive value of these variables for subsequent problematic short-video use. METHODS: A three-wave longitudinal survey with 6-month intervals was conducted among 1,327 students aged 16-18 years from five high schools in Yunnan Province, China. Physical exercise, learning burnout, and problematic short-video use were assessed using the Physical Activity Rating Scale-3 (PARS-3), the Adolescent Student Burnout Inventory, and the Short-Video Addiction Scale. Random-intercept cross-lagged panel modeling was used to separate stable between-person differences from within-person fluctuations while controlling for demographic and educational covariates. The longitudinal indirect association was estimated using 5,000 bias-corrected bootstrap samples. Supplementary ridge regression and extreme gradient boosting models, using nested cross-validation and a holdout test set, examined the incremental predictive value of physical exercise and learning burnout for later problematic short-video use. RESULTS: At the between-person level, higher long-term physical exercise was associated with lower learning burnout and problematic short-video use, whereas higher learning burnout was associated with higher problematic short-video use. At the within-person level, higher-than-usual physical exercise predicted lower subsequent learning burnout and problematic short-video use. Learning burnout and problematic short-video use showed positive reciprocal associations over time, and both predicted lower subsequent physical exercise. The longitudinal indirect association from physical exercise to later problematic short-video use through learning burnout was statistically significant but small. In supplementary machine-learning analyses, the best holdout R (2) was 0.311, but adding physical exercise and learning burnout did not improve prediction beyond prior problematic short-video use. SHAP results from the extended XGBoost model were therefore interpreted as exploratory feature attributions. CONCLUSION: Physical exercise, learning burnout, and problematic short-video use showed interconnected longitudinal associations among Chinese high school students. Learning burnout may represent one small longitudinal indirect pathway linking physical exercise to later problematic short-video use, while recent problematic short-video use provides the most informative signal for future risk. These findings may inform the development and evaluation of school-based health-promotion strategies that support physical exercise, address learning burnout, and respond to recent problematic-use symptoms. CI - Copyright (c) 2026 Yin, Peng, Chen, Wang, Liu, Xie and Gao. FAU - Yin, Tian AU - Yin T AD - Xiangtan University, Xiangtan, Hunan, China. AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Peng, Yanfeng AU - Peng Y AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Chen, Longjiang AU - Chen L AD - School of Physical Education, Yunnan Normal University, Kunming, Yunnan, China. FAU - Wang, Zetian AU - Wang Z AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Liu, Xu AU - Liu X AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Xie, Changcheng AU - Xie C AD - Hezhou University, Hezhou, Guangxi, China. FAU - Gao, Zeng AU - Gao Z AD - Xiangtan University, Xiangtan, Hunan, China. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13668801 OTO - NOTNLM OT - high school students OT - learning burnout OT - machine learning OT - physical exercise OT - problematic short-video use OT - random-intercept cross-lagged panel model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:13 MHDA- 2026/10/17 23:14 PMCR- 2026/10/01 CRDT- 2026/10/17 08:49 PHST- 2026/07/05 00:00 [received] PHST- 2026/08/30 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/17 23:14 [medline] PHST- 2026/10/17 23:13 [pubmed] PHST- 2026/10/17 08:49 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1929181 [doi] PST - epublish SO - Front Psychol. 2026 Oct 1;17:1929181. doi: 10.3389/fpsyg.2026.1929181. eCollection 2026. PMID- 42889007 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Policy themes and instruments in WHO and UNICEF child food-environment guidance, 2015-2025: a computational content analysis. PG - 1935052 LID - 10.3389/fnut.2026.1935052 [doi] LID - 1935052 AB - In children's food environments, global guidance can shape policy discourse and instrument choice, but its content does not establish implementation or outcomes. In 2015-2025, the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) published English-language guidance at the global level. A documented search, 2-author screening, and author-decision-masked expert review produced a corpus of 22 expert-refrozen documents (1,099 pages; 1,259 primary chunks). The BERTopic with document-capped discovery yielded six provisional clusters: food-marketing restrictions and children's rights; obesity burden; nutrition-sensitive social protection and service delivery; school, physical activity, and healthy food environments; infant and young child food promotion controls; and business engagement and food-industry governance. Among 978 chunks, marketing restrictions and children's rights accounted for 332 assigned chunks (33.9%). The expert accepted all descriptors and changed three of seven boundary decisions; applying those decisions and rerunning the full pipeline retained six identity-mapped clusters. Fixed-corpus seed and zoning diagnostics were favorable, but context expansion produced seven clusters and dominant-source removal substantially reorganized two source-concentrated clusters. To assess coding reliability, an 84-chunk exercise was archived under the earlier 19-document freeze; issuer and period profiles were descriptive. The study therefore provides a bound, auditable map rather than a stable taxonomy. Nutritional health literacy is a downstream interpretive application: no actual implementation process or literacy, behavioral, dietary-quality, or health outcome was measured. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13668553 OTO - NOTNLM OT - BERTopic OT - child nutrition OT - computational content analysis OT - food environments OT - food governance OT - nutritional health literacy OT - policy discourse OT - policy implementation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:13 MHDA- 2026/10/17 23:14 PMCR- 2026/10/01 CRDT- 2026/10/17 06:11 PHST- 2026/07/11 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/17 23:14 [medline] PHST- 2026/10/17 23:13 [pubmed] PHST- 2026/10/17 06:11 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fnut.2026.1935052 [doi] PST - epublish SO - Front Nutr. 2026 Oct 1;13:1935052. doi: 10.3389/fnut.2026.1935052. eCollection 2026. PMID- 42888994 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 3067-3534 (Electronic) IS - 3067-3518 (Print) IS - 3067-3518 (Linking) VI - 1 IP - 4 DP - 2026 Jul-Aug TI - Feasibility, Acceptability, and Efficacy of Using a Mobile Health Application for Lifestyle Modification in Youth With Prediabetes: A Prosper App Study. PG - 601-608 LID - 10.2337/doc26-0026 [doi] AB - OBJECTIVE: Mobile health (mHealth) applications (apps) help individuals achieve healthy lifestyle behaviors. We assessed feasibility, acceptability, and efficacy of an mHealth app, Prosper, in helping adolescents with prediabetes track and achieve lifestyle modifications. RESEARCH DESIGN AND METHODS: This prospective pilot study enrolled adolescents aged 13-17 years with prediabetes. Participants downloaded the Prosper app and use was followed for 3 months after a prediabetes visit. App use, check-ins, and habits data were analyzed; surveys assessed feasibility, acceptability, and participant-reported efficacy. Primary outcomes were use and feasibility or acceptability of the app. Secondary outcomes included changes in BMI and hemoglobin A(1c) (HbA(1c)). Caregivers and providers were also surveyed. RESULTS: The study enrolled 25 participants (median age 15.1 years; 76% female; 64% identified as Black adolescents; 76% identifed as non-Hispanic; and 56% had Medicaid insurance). Participants completed 2,057 habits, 575 check-ins, and 114 journals overall. The median number of check-ins per participant was 4 (interquartile range 2-18), and 36% completed >/=12 check-ins. Most participants (68%) set at least 2 habits, with a maximum of 14 habits. High satisfaction was reported by 74-87%. Most found the app easy to use (95.7-100%), helpful for tracking nutrition (61-78%) and exercise (56.5-86%), and easy to integrate into daily routines (52-73%). Baseline median BMI was 37.7 kg/m(2) (interquartile range 32.0-43.3) and HbA(1c) was 5.7% (interquartile range 5.6-5.8), without change noted after 3 months. CONCLUSIONS: Adolescents reported high satisfaction with the Prosper app and found it easy to use, helpful for tracking nutrition and exercise goals, and easy to incorporate into daily routines. mHealth tools may support adolescent lifestyle modifications between clinical visits with broad scalability. CI - (c) 2026 by the American Diabetes Association. FAU - Wang, Cynthia AU - Wang C AUID- ORCID: 0009-0003-9246-6595 AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Parimi, Neha AU - Parimi N AUID- ORCID: 0000-0003-1338-8270 AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Patel, Dhruva AU - Patel D AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Williams, Hannah AU - Williams H AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Malina, Sara N AU - Malina SN AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Wolf, Risa M AU - Wolf RM AUID- ORCID: 0000-0001-7674-520X AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Hitt, Talia A AU - Hitt TA AUID- ORCID: 0000-0003-4491-3648 AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. LA - eng SI - figshare/10.2337/figshare.32249199 PT - Journal Article DEP - 20260629 PL - United States TA - Diabetes Obes Cardiometab CARE JT - Diabetes, obesity, and cardiometabolic CARE JID - 9919229522706676 PMC - PMC13644839 COIS- R.M.W. previously served in an unpaid advisory role to Uneo Inc. ("Uneo Health"), the company that developed the mobile application evaluated in this study. R.M.W. reports receiving research support from Lilly Diabetes, Novo Nordisk, and Sanofi unrelated to the submitted work. No other potential conflicts of interest relevant to this article were reported. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/06/29 CRDT- 2026/10/17 06:02 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 06:02 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 260026 [pii] AID - 10.2337/doc26-0026 [doi] PST - epublish SO - Diabetes Obes Cardiometab CARE. 2026 Jun 29;1(4):601-608. doi: 10.2337/doc26-0026. eCollection 2026 Jul-Aug. PMID- 42886664 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Validation of HemoCue method and development of a revised hemoglobin cut-off to detect anemia in children aged 6-24-months. PG - e0346506 LID - 10.1371/journal.pone.0346506 [doi] LID - e0346506 AB - BACKGROUND: Accurate hemoglobin (Hb) measurement is essential for determining anemia prevalence at the population level. The HemoCue method, commonly used in resource poor settings, has been shown to overestimate Hb levels compared to the direct cyanmethemoglobin (DCM) method, leading to an underestimation of anemia. We aimed to validate the HemoCue method against the DCM method and establish an optimal cut-off value for diagnosing anemia in children under two. METHODS: Data were collected from children under two years of age as part of the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development study in Bangladesh, conducted in Mirpur, Dhaka, from February 2010 to February 2017. Using HemoCue 201 instrument and DCM method, Hb levels were measured in 846 venous blood samples collected from 589 children. Quadratic regression was explored to derive a correction factor; however, substantial dispersion in HemoCue measurements prevented establishment of a reliable correction model. Youden's Index was used to identify the optimal cut‑off. While it provided a strong threshold, we prioritized achieving at least 70% sensitivity and specificity to confirm balanced diagnostic performance. RESULTS: The median (IQR) Hb concentrations estimated by HemoCue and DCM were 11.6 (10.5, 12.5) g/dL and 10.8 (10.1, 11.5) g/dL, respectively. Using a cut-off of <10.5 g/dL for anemia, the prevalence was significantly higher with the DCM method (35.2% vs. 23.2%, p < 0.001). Considering DCM as the gold standard, the sensitivity and specificity of the HemoCue method were 93% and 53%, respectively. In the test/train analysis, the newly identified cut-off of 11.00 g/dL, indicated an anemia prevalence of 34.2% in the testing dataset, with a sensitivity of 84% and specificity of 69%. CONCLUSION: This study highlights substantial variability between HemoCue and DCM hemoglobin measurements, which prevented development of a reliable correction factor. The proposed HemoCue cut-off of 11.0 g/dL may improve anemia detection in children under two years of age when compared with the currently recommended threshold. CI - Copyright: (c) 2026 Mahfuz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Khan, Ar-Rafi AU - Khan AR AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Hasan, S M Tafsir AU - Hasan SMT AUID- ORCID: 0000-0002-6062-4072 AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Hossain, Md Shabab AU - Hossain MS AUID- ORCID: 0000-0002-2862-8639 AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Rezwan, A H M AU - Rezwan AHM AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Mahfuz, Mehjabin Tishan AU - Mahfuz MT AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Alam, Md Ashraful AU - Alam MA AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. AD - Office of Executive Director, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. LA - eng PT - Journal Article PT - Validation Study DEP - 20261016 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Hemoglobins) SB - IM MH - Humans MH - *Hemoglobins/analysis MH - *Anemia/diagnosis/blood/epidemiology MH - Infant MH - Male MH - Child, Preschool MH - Female MH - Sensitivity and Specificity MH - Bangladesh/epidemiology MH - Prevalence PMC - PMC13674700 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/16 19:05 MHDA- 2026/10/16 19:06 PMCR- 2026/10/16 CRDT- 2026/10/16 13:35 PHST- 2026/03/20 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/10/16 19:06 [medline] PHST- 2026/10/16 19:05 [pubmed] PHST- 2026/10/16 13:35 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - PONE-D-26-09930 [pii] AID - 10.1371/journal.pone.0346506 [doi] PST - epublish SO - PLoS One. 2026 Oct 16;21(10):e0346506. doi: 10.1371/journal.pone.0346506. eCollection 2026. PMID- 42886345 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261027 IS - 1432-1106 (Electronic) IS - 0014-4819 (Linking) VI - 244 IP - 12 DP - 2026 Oct 16 TI - A multimodal framework to assess differences in dynamic visual acuity between athletes with and without recent sport-related concussion. LID - 212 [pii] LID - 10.1007/s00221-026-07409-4 [doi] AB - Sport-related concussions (SRC) commonly affect vision and cognition, but there is limited understanding of how concurrent balance and exertion demands may affect visual-cognitive performance beyond symptom resolution.Purpose To determine if a dynamic visual acuity (DVA) task performed during standing and walking could differentiate performance between athletes with and without concussion history.Methods Interuniversity athletes (N = 30, age = 20.9 years +/- 1.4) with SRC history who were asymptomatic (SRC = 14; females = 6) were compared to athletes without SRC (CONTROL = 16; female = 7). A DVA task was completed while seated, standing, and during low- and moderate-intensity treadmill walking. A Tumbling 'E' target was presented randomly in either random walk (R) or horizontal (H) motion (2.31 m/s), in one of four orientations; responses were selected using a handheld keypad. Performance was characterized as a change in DVA score from Seated (logMAR) and response time (RT, ms). A linear mixed-effects model was fitted for DVA change scores and a generalized mixed effects model for median RT.Results The SRC group exhibited worse DVA change scores during standing and walking compared to CONTROL (p < .05) during R-motion only. Whereas both groups responded faster during treadmill walking for both R- and H-motion (p < .001). Only two athletes (14%) in the SRC group experienced mild symptoms that did not affect performance during the protocol.Conclusion A multimodal DVA assessment, including standing and walking conditions, may be a feasible approach to detect differences in visual-cognitive performance for athletes following clinical recovery of concussion. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Mitchell, Katelyn M AU - Mitchell KM AD - Department of Kinesiology and Phys. Ed., Wilfrid Laurier University, Waterloo, ON, Canada. AD - University of Toronto, Toronto, ON, Canada. FAU - Dalton, Kristine N AU - Dalton KN AD - University of Waterloo, Waterloo, ON, Canada. FAU - Cinelli, Michael E AU - Cinelli ME AUID- ORCID: 0000-0002-5802-2590 AD - Department of Kinesiology and Phys. Ed., Wilfrid Laurier University, Waterloo, ON, Canada. mcinelli@wlu.ca. LA - eng GR - 2019-05894/Natural Sciences and Engineering Research Council of Canada/ PT - Journal Article DEP - 20261016 PL - Germany TA - Exp Brain Res JT - Experimental brain research JID - 0043312 SB - IM MH - Humans MH - *Brain Concussion/physiopathology/diagnosis MH - Female MH - *Athletic Injuries/physiopathology/complications/diagnosis MH - Young Adult MH - *Visual Acuity/physiology MH - Male MH - *Athletes MH - *Postural Balance/physiology MH - *Psychomotor Performance/physiology MH - Walking/physiology MH - Adolescent MH - Reaction Time/physiology MH - Dual-Task Tests OTO - NOTNLM OT - Balance OT - Cognition OT - Concussion OT - Exercise OT - Vision COIS- Declarations. Competing interests: KD is a coinventor of the moV& (V&MP Vision Suite, Waterloo, Canada) software used in this study to examine dynamic visual acuity and is currently exploring commercialization options for this device; however, the device is not available commercially at the moment. KM is an employee in the Canadian Football League (CFL) and member of the CFL Medical Committee. MC has no conflicts of interest to declare. EDAT- 2026/10/16 19:04 MHDA- 2026/10/16 19:05 CRDT- 2026/10/16 11:20 PHST- 2026/07/02 00:00 [received] PHST- 2026/10/05 00:00 [accepted] PHST- 2026/10/16 19:05 [medline] PHST- 2026/10/16 19:04 [pubmed] PHST- 2026/10/16 11:20 [entrez] AID - 10.1007/s00221-026-07409-4 [pii] AID - 10.1007/s00221-026-07409-4 [doi] PST - epublish SO - Exp Brain Res. 2026 Oct 16;244(12):212. doi: 10.1007/s00221-026-07409-4. PMID- 42885213 OWN - NLM STAT- Publisher LR - 20261028 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Oct 15 TI - Multimodal prediction of infliximab initiation within 6 months after initiation of conventional therapy in pediatric Crohn's disease: A multicenter algorithm development and validation study. LID - 10.1002/jpn3.70602 [doi] AB - OBJECTIVES: Early prediction of treatment course in pediatric Crohn's disease (CD) remains limited despite the importance of timely biologic therapy. We developed and externally validated a multimodal model integrating colonoscopy images and clinical data to predict infliximab initiation within 6 months after conventional therapy. METHODS: We collected data from children newly diagnosed with CD at three hospitals: Seoul National University Bundang Hospital for internal validation, Kyung Hee University Medical Center, and Soonchunhyang University Bucheon Hospital for external validation. Each patient contributed 7 endoscopic images and 20 clinical variables. An attention-based multiple-instance learning framework aggregated endoscopic images into a patient-level representation and integrated them with clinical features. The imaging encoder used a ResNet-50 backbone pretrained with momentum contrastive learning on GastroNet-5M, and clinical features were encoded using a multilayer perceptron. Performance was assessed using the area under the receiver operating characteristic curve (AUROC), balanced accuracy, precision, recall, and F1 score. Explainable AI was evaluated using attention maps (image data) and SHAP values (tabular data). RESULTS: Seventy-seven children were included for model development and internal validation, with external validation performed in two independent cohorts (n = 10 and n = 20). The multimodal model achieved an AUROC of 0.839 and balanced accuracy of 0.732 in the discovery cohort. External-validation AUROCs were 0.857 and 0.688. SHapley Additive exPlanation analysis identified immunoglobulin G, body mass index, prealbumin, hematocrit, and age as key predictors. Attention maps highlighted inflamed mucosa and ulcerative lesions. CONCLUSION: A multimodal model integrating colonoscopy images with clinical data showed promising performance for predicting infliximab initiation within 6 months after conventional therapy in pediatric CD. Multimodal information may support early risk stratification and identify patients who could benefit from earlier biologic intervention. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Kim, Seon Young AU - Kim SY AUID- ORCID: 0000-0001-6433-0242 AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, South Korea. FAU - Hwang, Seung Ha AU - Hwang SH AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin, South Korea. FAU - Yeo, Dongjin AU - Yeo D AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Kim, Juyeong AU - Kim J AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. FAU - Hwangbo, Gyeom AU - Hwangbo G AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Kim, Do Hyun AU - Kim DH AUID- ORCID: 0000-0003-0064-1732 AD - Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea. FAU - Lee, Yoo Min AU - Lee YM AD - Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. FAU - Woo, Selin AU - Woo S AUID- ORCID: 0000-0001-7961-2074 AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Hahn, Jong Woo AU - Hahn JW AUID- ORCID: 0000-0001-6331-1314 AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea. AD - Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea. FAU - Yon, Dong Keon AU - Yon DK AUID- ORCID: 0000-0003-1628-9948 AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, South Korea. AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin, South Korea. AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. LA - eng GR - RS-2024-00509257/Ministry of Science and ICT, South Korea/ GR - IITP-2026-RS-2024-00438239/Ministry of Science and ICT, South Korea/ GR - RS-2025-02220492/Ministry of Health and Welfare/ PT - Journal Article DEP - 20261015 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - SHAP OT - biologic therapy OT - endoscopic imaging OT - inflammatory bowel disease EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:33 CRDT- 2026/10/16 02:23 PHST- 2026/09/09 00:00 [revised] PHST- 2026/06/08 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 02:23 [entrez] AID - 10.1002/jpn3.70602 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Oct 15. doi: 10.1002/jpn3.70602. PMID- 42884734 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 6 TI - Lipid-Adjusted Vitamin E Status in Children with Chronic Liver Disease: Reclassification Patterns and Differences According to Cholestasis and Liver Transplantation. LID - 10.3390/nu18193283 [doi] LID - 3283 AB - BACKGROUND: Serum alpha-tocopherol depends on lipids, so absolute concentrations misclassify vitamin E status in children with chronic liver disease (CLD). The CALIPER program defined lipid-adjusted E:cholesterol (E:C) and E:triglyceride (E:TG) ratios, but their application in mixed-etiology pediatric CLD using immunoassay has not been reported. METHODS: Exploratory single-center cross-sectional study of 66 children (observed age range 4 months-17.9 years) with mixed-etiology CLD. Retinol and total vitamin E were measured by ELISA, whereas the CALIPER reference intervals applied here were established for alpha-tocopherol measured by HPLC; the two platforms are not interchangeable, so every classification reported is an exploratory application of those cutoffs. Vitamin E status was classified by absolute concentration, E:C (<3.7) and E:TG (<8.5). Cholestatic (n = 15), non-cholestatic (n = 45) and post-transplant (n = 6) groups were compared. RESULTS: Vitamin A was largely preserved (5.2% below WHO). Vitamin E was low in 45.3% by absolute concentration, 62.5% by E:C and 43.8% by E:TG. Of 35 children with a normal absolute vitamin E concentration, 11 (31.4%) were reclassified as low by E:C. Low E:C differed across groups (cholestatic 78.6%, non-cholestatic 63.6%, post-transplant 16.7%; p = 0.030). E:TG was inversely correlated with 25(OH)D (rho = -0.45; p < 0.001). CONCLUSIONS: Lipid-adjusted interpretation reclassified a substantial proportion of children whose absolute vitamin E concentration appeared adequate, and the prevalence of a low E:C ratio was lower among post-transplant participants than in the other two groups. In this exploratory cohort, the E:C ratio showed greater potential than the E:TG ratio for lipid-adjusted interpretation of vitamin E status; prospective validation against HPLC-based measurements and established functional indices is required before routine clinical adoption. FAU - Adam, Sorina AU - Adam S AUID- ORCID: 0000-0002-2074-0714 AD - "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. FAU - Grama, Alina AU - Grama A AD - 2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. AD - 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400124 Cluj-Napoca, Romania. FAU - Mititelu, Alexandra AU - Mititelu A AUID- ORCID: 0000-0002-0955-4486 AD - 2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. AD - 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400124 Cluj-Napoca, Romania. FAU - Benta, Gabriel AU - Benta G AUID- ORCID: 0000-0002-2099-8379 AD - 2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. AD - 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400124 Cluj-Napoca, Romania. FAU - Chereches, Razvan M AU - Chereches RM AD - HIVE Health Innovation Center, Babes-Bolyai University, 400095 Cluj-Napoca, Romania. FAU - Pop, Tudor Lucian AU - Pop TL AUID- ORCID: 0000-0002-4931-1219 AD - 2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. AD - 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400124 Cluj-Napoca, Romania. LA - eng GR - 771/60/11.01.2023 and 647/53/11.01.2024/Iuliu Hatieganu University of Medicine and Pharmacy/ GR - 100418/29.08.2025, SMIS code 350525/Ministry of Research and Innovation/ PT - Journal Article DEP - 20261006 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-18-4 (Vitamin E) RN - 0 (Lipids) RN - H4N855PNZ1 (alpha-Tocopherol) RN - 11103-57-4 (Vitamin A) RN - 97C5T2UQ7J (Cholesterol) RN - 0 (Triglycerides) SB - IM MH - Humans MH - Child MH - Child, Preschool MH - Female MH - Infant MH - *Vitamin E/blood MH - Cross-Sectional Studies MH - Male MH - Adolescent MH - *Liver Transplantation MH - *Cholestasis/blood MH - *Liver Diseases/blood/surgery MH - Chronic Disease MH - *Lipids/blood MH - alpha-Tocopherol/blood MH - *Vitamin E Deficiency/blood MH - Vitamin A/blood MH - Cholesterol/blood MH - Triglycerides/blood MH - Nutritional Status PMC - PMC13666619 OTO - NOTNLM OT - cholestasis OT - fat-soluble vitamins OT - lipid-adjusted vitamin E OT - liver transplantation OT - pediatric chronic liver disease OT - vitamin E OT - vitamin E-to-cholesterol ratio OT - alpha-tocopherol COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/06 CRDT- 2026/10/16 01:10 PHST- 2026/08/15 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/10/01 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - nu18193283 [pii] AID - nutrients-18-03283 [pii] AID - 10.3390/nu18193283 [doi] PST - epublish SO - Nutrients. 2026 Oct 6;18(19):3283. doi: 10.3390/nu18193283. PMID- 42884725 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 5 TI - Turkish Adaptation of the Clean Food Consumerism Scale: A Validity and Reliability Study. LID - 10.3390/nu18193274 [doi] LID - 3274 AB - Background: Clean food consumerism reflects consumers' preferences for foods perceived as natural, authentic, transparent, and health-promoting. This study aimed to culturally adapt the Clean Food Consumerism Scale (CFCS) into Turkish and evaluate its psychometric properties. Methods: The CFCS was translated, back-translated, reviewed by experts, pilot-tested, and psychometrically evaluated. For the pilot study and factor analyses, the Turkish version was administered to 1637 adults, who were allocated to three mutually exclusive subsamples: n = 180 for the pilot study, n = 500 for EFA, and n = 957 for CFA. An additional, separate sample of 124 participants completed the CFCS twice at a three-week interval for the test-retest analysis. Internal consistency, construct validity, convergent validity, discriminant validity, criterion validity, and test-retest reliability were assessed using Cronbach's alpha, item-total correlations, EFA, CFA, composite reliability (CR), average variance extracted (AVE), the Fornell-Larcker criterion, heterotrait-monotrait (HTMT) ratios, correlations with the Sustainable and Healthy Eating Behaviors Scale (SHEBS), and test-retest correlations. Results: The 18-item CFCS demonstrated excellent internal consistency (Cronbach's alpha = 0.948). Sampling adequacy was supported by the KMO value (0.927) and significant Bartlett's test (chi(2) = 7525.229, p < 0.001). EFA supported a five-factor structure comprising Perceived Health Benefits, Production Process Transparency, Authenticity, Perceived Ease of Use, and Familiarity, explaining 80.92% of the total variance. CFA supported the five-factor model. After adding one content-justified residual covariance between two closely related Perceived Health Benefits items, the final model showed acceptable fit (chi(2) = 641.39, df = 124, p < 0.001; CFI = 0.965, TLI = 0.956, NFI = 0.957, RMSEA = 0.066 [90% CI 0.061-0.071], SRMR = 0.047, GFI = 0.926, AGFI = 0.899). Standardized factor loadings ranged from 0.748 to 0.938, composite reliability from 0.873 to 0.940, and average variance extracted from 0.697 to 0.771. HTMT ratios for all factor pairs remained below 0.685 and the Fornell-Larcker criterion was satisfied for every factor, supporting discriminant validity. Test-retest reliability over three weeks was excellent (r = 0.889, p < 0.001), and CFCS scores were positively correlated with SHEBS scores (r = 0.441, p < 0.001). Conclusions: The Turkish version of the CFCS demonstrated strong validity, reliability, and temporal stability while preserving the original five-factor structure. It provides a psychometrically sound instrument for assessing clean food consumerism among Turkish-speaking adults and may support future research in nutrition, public health, sustainability, and consumer behavior. FAU - Sipahi Uygur, Simge AU - Sipahi Uygur S AUID- ORCID: 0000-0002-3070-0601 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Cakir Bicer, Nihan AU - Cakir Bicer N AUID- ORCID: 0000-0002-7581-9083 AD - Department of Molecular Gastroenterology and Hepatology, Institute of Gastroenterology and Hepatology, Kocaeli University, Kocaeli 41001, Turkiye. FAU - Ones, Ece AU - Ones E AUID- ORCID: 0000-0002-9936-8475 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Roberts, Sena AU - Roberts S AUID- ORCID: 0000-0002-6052-109X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Koksal, Selen AU - Koksal S AUID- ORCID: 0000-0002-1181-3619 AD - Department of Culinary, Vocational School, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Turker, Perim Fatma AU - Turker PF AUID- ORCID: 0000-0002-4254-3711 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Bas, Murat AU - Bas M AUID- ORCID: 0000-0002-0494-301X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20261005 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Turkey MH - Female MH - Reproducibility of Results MH - Male MH - Adult MH - Psychometrics MH - *Consumer Behavior MH - Middle Aged MH - Pilot Projects MH - Young Adult MH - Surveys and Questionnaires MH - *Diet, Healthy MH - *Food Preferences/psychology MH - Adolescent PMC - PMC13666638 OTO - NOTNLM OT - Turkish adaptation OT - clean food consumerism OT - psychometric evaluation OT - reliability OT - scale adaptation OT - sustainable nutrition OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/05 CRDT- 2026/10/16 01:10 PHST- 2026/07/01 00:00 [received] PHST- 2026/09/21 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - nu18193274 [pii] AID - nutrients-18-03274 [pii] AID - 10.3390/nu18193274 [doi] PST - epublish SO - Nutrients. 2026 Oct 5;18(19):3274. doi: 10.3390/nu18193274. PMID- 42884723 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 5 TI - Association Between Eating Attitudes and Dental Caries Experience in Young Adults Attending a Private Dental Practice: A Cross-Sectional Study. LID - 10.3390/nu18193273 [doi] LID - 3273 AB - BACKGROUND/OBJECTIVES: Eating attitudes may be linked to oral health through behavioral and lifestyle mechanisms, but data on young adults remain limited. The primary objective was to assess the association between dietary attitudes and caries experience in young adults recruited from a private dental practice. Secondary analyses examined the psychometric properties of the EAT-40 and the relationships of its scores with BMI, oral health behaviors, and lifestyle factors. METHODS: A cross-sectional study included 366 adults aged 18-25 years recruited by convenience sampling from a private dental practice in Iasi. Eating attitudes were assessed using the EAT-40, oral health behaviors using the HU-DBI, and caries experience using the DMFT and DMFS indices. BMI was calculated based on self-reported weight and height. Exploratory factor analysis, Spearman correlations, negative binomial regression, and multiple linear regression were used. RESULTS: The EAT-40 showed good internal consistency (alpha = 0.887), and the three-factor solution explained 36.6% of the variance. The total EAT-40 score showed weak positive correlations with DMFT and DMFS (rho = 0.146; p = 0.005 for both), but was not significantly associated with DMFS in the fully adjusted model (IRR = 1.003; 95% CI: 0.997-1.010; p = 0.293) or in the sensitivity analysis (IRR = 1.005; 95% CI: 0.999-1.012; p = 0.122). None of the three EAT-40 dimensions was significantly associated with DMFS after adjustment. The total EAT-40 score was not significantly associated with BMI. Daily smoking was associated with higher DMFS values, whereas occasional smoking was not. CONCLUSIONS: In the study sample, EAT-40 scores were weakly associated with caries experience, but not independently with BMI. The results regarding EAT-40 dimensions remain exploratory, and the cross-sectional design does not allow for causal conclusions. FAU - Armencia, Adina Oana AU - Armencia AO AUID- ORCID: 0000-0003-0921-4382 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Nicolau, Andrei AU - Nicolau A AUID- ORCID: 0000-0002-1423-3820 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Vasluianu, Roxana Ionela AU - Vasluianu RI AUID- ORCID: 0000-0003-0867-1135 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Bolos, Alexandra AU - Bolos A AUID- ORCID: 0009-0007-1247-0383 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Balcos, Carina Ana-Maria AU - Balcos CA AUID- ORCID: 0000-0001-7712-1319 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Ioanid, Nicoleta AU - Ioanid N AUID- ORCID: 0009-0003-7558-3730 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Condurache, Gabriel AU - Condurache G AD - Private Dental Practice, 700106 Iasi, Romania. FAU - Vitalariu, Anca Mihaela AU - Vitalariu AM AUID- ORCID: 0000-0002-8341-8810 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Gradinaru, Irina AU - Gradinaru I AUID- ORCID: 0000-0002-1676-4668 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Macovei, Georgiana AU - Macovei G AUID- ORCID: 0000-0003-1152-4216 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. LA - eng PT - Journal Article DEP - 20261005 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Dental Caries/epidemiology/psychology MH - Young Adult MH - Male MH - Adult MH - Adolescent MH - *Feeding Behavior/psychology MH - Oral Health MH - Body Mass Index MH - DMF Index MH - Health Behavior MH - Life Style MH - Psychometrics PMC - PMC13666866 OTO - NOTNLM OT - body mass index OT - dental caries OT - feeding behavior OT - health behavior OT - young adult COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/05 CRDT- 2026/10/16 01:10 PHST- 2026/09/09 00:00 [received] PHST- 2026/09/30 00:00 [revised] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - nu18193273 [pii] AID - nutrients-18-03273 [pii] AID - 10.3390/nu18193273 [doi] PST - epublish SO - Nutrients. 2026 Oct 5;18(19):3273. doi: 10.3390/nu18193273. PMID- 42884717 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 3 TI - Association of Nutritional Status at Diagnosis with Disease Course in Pediatric Inflammatory Bowel Disease. LID - 10.3390/nu18193266 [doi] LID - 3266 AB - BACKGROUND: Growth impairment is a major component of pediatric inflammatory bowel disease (IBD), yet the prognostic role of baseline nutritional status remains debated. We assessed the impact of nutritional status at diagnosis on subsequent medical and surgical disease course. METHODS: We retrospectively studied 183 children with IBD (84 Crohn's disease, 99 ulcerative colitis) followed for at least 18 months. Patients were classified at diagnosis using BMI Z-scores as underweight (n = 35), normal weight (n = 123), or overweight/obese (n = 25). Multivariable regression models-adjusted for diagnosis, biological sex, age at diagnosis, and extraintestinal manifestations/comorbidities-evaluated relapse burden, surgical resection, and longitudinal anthropometric recovery at last follow-up. RESULTS: Baseline underweight status was not independently associated with a higher relapse burden or time to first relapse. A sensitivity analysis excluding surgically resected patients showed higher estimated relapse rates for underweight patients, though these did not reach statistical significance. In exploratory analyses, baseline underweight showed a borderline, non-significant association with subsequent surgical resection (adjusted OR 2.68, 95% CI 0.97-7.27; p = 0.056), warranting validation in larger prospective cohorts. Exploratory VEO-IBD analyses were limited by small subgroup size; within UC, a higher crude resection frequency was observed in VEO-UC than in older-onset UC (15.0% vs. 1.3%), but this finding should be interpreted cautiously. At follow-up, 85.7% of initially underweight patients reached normal weight. Higher baseline BMI Z-score was independently associated with higher follow-up BMI Z-score, whereas therapeutic escalation and total relapse burden were not independently associated with follow-up BMI Z-score. Persistent stunting was very rare (1.9%), precluding multivariable analysis. CONCLUSIONS: Baseline underweight showed a suggestive but non-significant association with subsequent surgical resection, warranting confirmation in larger prospective cohorts, while it was not independently associated with medical disease instability. Substantial weight recovery occurred during pediatric IBD follow-up. Baseline BMI Z-score was associated with BMI Z-score at follow-up, although substantial between-patient variability remained unexplained. FAU - Morelli, Annalisa AU - Morelli A AUID- ORCID: 0000-0002-9052-0266 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Pediatrics Section, University of Salerno, 84081 Baronissi, Italy. FAU - Caprarelli, Michela AU - Caprarelli M AUID- ORCID: 0000-0001-7166-6545 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Pediatrics, Universita Cattolica del Sacro Cuore, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy. FAU - Ruiz, Roberta Giusy AU - Ruiz RG AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Mazzoli, Bianca AU - Mazzoli B AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Pediatrics, Universita Cattolica del Sacro Cuore, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy. FAU - Salatto, Alessia AU - Salatto A AUID- ORCID: 0000-0002-3613-4823 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Pediatrics, University Federico II of Naples, Via Sergio Pansini 5, 80131 Naples, Italy. FAU - Knafelz, Daniela AU - Knafelz D AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Bracci, Fiammetta AU - Bracci F AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Cardile, Sabrina AU - Cardile S AUID- ORCID: 0000-0003-2912-3154 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Bolasco, Giulia AU - Bolasco G AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Trovato, Chiara Maria AU - Trovato CM AUID- ORCID: 0000-0003-3869-1815 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - De Angelis, Paola AU - De Angelis P AD - Gastroenterology, Digestive Endoscopy and Nutrition Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Romeo, Erminia Francesca AU - Romeo EF AD - Gastroenterology, Digestive Endoscopy and Nutrition Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Diamanti, Antonella AU - Diamanti A AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. LA - eng PT - Journal Article DEP - 20261003 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Pediatric Crohn's disease SB - IM MH - Humans MH - *Nutritional Status MH - Female MH - Male MH - Retrospective Studies MH - Child MH - Thinness/complications MH - Recurrence MH - Adolescent MH - *Colitis, Ulcerative/diagnosis/complications/physiopathology MH - Body Mass Index MH - Disease Progression MH - *Crohn Disease/diagnosis/complications/physiopathology MH - Prognosis MH - *Inflammatory Bowel Diseases/diagnosis/complications MH - Child, Preschool PMC - PMC13667242 OTO - NOTNLM OT - IBD OT - disease course OT - nutritional status COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/03 CRDT- 2026/10/16 01:10 PHST- 2026/08/23 00:00 [received] PHST- 2026/09/19 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/03 00:00 [pmc-release] AID - nu18193266 [pii] AID - nutrients-18-03266 [pii] AID - 10.3390/nu18193266 [doi] PST - epublish SO - Nutrients. 2026 Oct 3;18(19):3266. doi: 10.3390/nu18193266. PMID- 42884699 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 1 TI - Parenteral Nutrition Exposure, Nutritional Trajectory, and Clinical Outcomes in Neonates with Surgical Gastrointestinal Conditions: A Retrospective Cohort Study. LID - 10.3390/nu18193251 [doi] LID - 3251 AB - Background/Objectives: Neonates with surgical gastrointestinal conditions frequently require parenteral nutrition and are exposed to multiple overlapping risks for hepatobiliary, infectious, and nutritional complications. This study aimed to determine whether the timing and initial composition of parenteral nutrition (PN) were independently associated with hepatobiliary dysfunction, treatment-related complications, and nutritional outcomes. Methods: This retrospective cohort included 91 neonates hospitalized at the University Children's Hospital between January 2024 and July 2026 who received parenteral nutrition (PN) for >5 consecutive days. Associations between PN timing, modality, duration, enteral progression, clinical severity, feeding type, and hepatobiliary, infectious, and growth outcomes were assessed using univariable and multivariable analyses. Results: Cholestasis occurred in 18 patients (19.8%) and intestinal failure-associated liver disease (IFALD) in 14 (15.4%). The interval from enteral feeding cessation to PN initiation and initial PN modality were not significantly associated with cholestasis or IFALD. Patients with IFALD had longer PN exposure than those without IFALD (21 vs. 12 days; p = 0.010). Each additional PN day increased the adjusted odds of catheter-related bloodstream infection by 9.7% (OR 1.097, 95% CI 1.032-1.167; p = 0.003). Simultaneous amino-acid and lipid initiation was associated with the highest unadjusted weight-gain velocity and numerically lowest cholestasis and IFALD rates, but no independent protective effect was established. Conclusions: Longer PN duration was associated with IFALD and CRBSI, although the IFALD association should be interpreted cautiously because PN duration contributes to its operational definition. Short delays in PN initiation and initial lipid timing were not independently associated with these outcomes. Management should remain individualized, with advancement of enteral nutrition when clinically feasible and minimization of unnecessary PN and central-line exposure. FAU - Zekovic, Luka AU - Zekovic L AD - Department of Neonatology, University Children's Hospital, 11000 Belgrade, Serbia. FAU - Nikolic, Dejan AU - Nikolic D AUID- ORCID: 0000-0002-0609-9916 AD - Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia. AD - Department of Physical Medicine and Rehabilitation, University Children's Hospital, 11000 Belgrade, Serbia. FAU - Sindjic-Antunovic, Sanja AU - Sindjic-Antunovic S AD - Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia. AD - Department of Neonatal Surgery, University Children's Hospital, 11000 Belgrade, Serbia. FAU - Medjo, Biljana AU - Medjo B AD - Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia. AD - Department of Pediatric Intensive Care Unit, University Children's Hospital, 11000 Belgrade, Serbia. FAU - Vujovic, Dragana AU - Vujovic D AUID- ORCID: 0009-0003-5329-5439 AD - Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia. AD - Department of Neonatal Surgery, University Children's Hospital, 11000 Belgrade, Serbia. FAU - Grubac, Zeljko AU - Grubac Z AUID- ORCID: 0000-0002-0812-2438 AD - Department for Esophagogastric Disease, Clinic for Digestive Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia. FAU - Ristic, Nina AU - Ristic N AUID- ORCID: 0000-0003-2731-3042 AD - Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia. AD - Department of Gastroenterology, Hepatology and GI Endoscopy, University Children's Hospital, 11000 Belgrade, Serbia. FAU - Jeremic, Rastko Sava AU - Jeremic RS AD - Department of Neonatal Surgery, University Children's Hospital, 11000 Belgrade, Serbia. FAU - Raus, Misela AU - Raus M AUID- ORCID: 0009-0002-4762-9175 AD - Department of Neonatology, University Children's Hospital, 11000 Belgrade, Serbia. AD - Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Parenteral Nutrition/adverse effects/methods MH - Retrospective Studies MH - Infant, Newborn MH - Male MH - Female MH - Cholestasis/etiology MH - Liver Diseases/etiology MH - *Gastrointestinal Diseases/therapy/surgery MH - Treatment Outcome MH - Intestinal Failure/etiology MH - Nutritional Status MH - Time Factors MH - *Digestive System Surgical Procedures/adverse effects PMC - PMC13667157 OTO - NOTNLM OT - catheter-related bloodstream infection OT - cholestasis OT - clinical outcomes OT - enteral nutrition OT - intestinal failure-associated liver disease OT - neonates OT - nutritional trajectory OT - parenteral nutrition OT - surgical gastrointestinal conditions COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/01 CRDT- 2026/10/16 01:10 PHST- 2026/08/26 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - nu18193251 [pii] AID - nutrients-18-03251 [pii] AID - 10.3390/nu18193251 [doi] PST - epublish SO - Nutrients. 2026 Oct 1;18(19):3251. doi: 10.3390/nu18193251. PMID- 42884698 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 1 TI - Fit-Ideal Internalisation and Disordered Eating in Adolescent Girls: Psychometric Evaluation and Incremental Validity of the Fit Internalization Test. LID - 10.3390/nu18193248 [doi] LID - 3248 AB - OBJECTIVES: The present study aimed to validate the Lithuanian translation of the Fit Ideal Internalization Test (FIIT) in adolescent girls. METHODS: A total of 1067 girls (mean age = 17.27, SD = 0.61; age range = 15-19 years) participated in the study. FIIT, muscular ideal internalization, body dissatisfaction (BD), disordered eating (DE), body appreciation (BA), and exercise motivation were assessed. RESULTS: Exploratory factor analysis (n = 534) replicated the original three-factor structure, explaining 74.43% of the total variance. Confirmatory factor analysis (n = 533) supported the three-factor model, with strong factor loadings. Composite reliability was excellent (McDonald's omega = 0.919-0.969). Measurement invariance was established across sport participation groups, and sport-involved girls reported higher Fit Drive, Fit Overvaluation, and FIIT total scores than non-sport-involved girls. All FIIT subscales were positively associated with muscular internalization, BD, and DE and negatively associated with BA, while Fit Idealisation and Fit Overvaluation showed weak negative associations with autonomous exercise motivation, consistent with the hypothesised pattern of associations. The FIIT explained significant additional variance in DE beyond body mass index, BD, and muscular ideal internalization, with Fit Idealisation showing the strongest unique association (beta = 0.401, p < 0.001). CONCLUSIONS: The Lithuanian FIIT appears to be a psychometrically sound instrument for assessing fit ideal internalization among Lithuanian adolescent girls. FAU - Baceviciene, Migle AU - Baceviciene M AUID- ORCID: 0000-0002-9819-2316 AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto 6, 44221 Kaunas, Lithuania. FAU - Balciuniene, Vaiva AU - Balciuniene V AUID- ORCID: 0000-0002-9986-9771 AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto 6, 44221 Kaunas, Lithuania. FAU - Jankauskiene, Rasa AU - Jankauskiene R AUID- ORCID: 0000-0001-5950-0884 AD - Institute of Sport Science and Innovations, Lithuanian Sports University, Sporto 6, 44221 Kaunas, Lithuania. LA - eng PT - Journal Article PT - Validation Study DEP - 20261001 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Feeding and Eating Disorders/psychology/diagnosis MH - *Psychometrics MH - *Body Image/psychology MH - Reproducibility of Results MH - Young Adult MH - Body Satisfaction MH - Motivation MH - Exercise/psychology MH - Factor Analysis, Statistical MH - Lithuania MH - Body Dissatisfaction/psychology MH - Surveys and Questionnaires MH - Sports/psychology PMC - PMC13666705 OTO - NOTNLM OT - adolescent girls OT - body image OT - disordered eating OT - fit ideal internalization OT - measurement invariance OT - psychometric validation OT - sports COIS- The authors report no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/01 CRDT- 2026/10/16 01:10 PHST- 2026/09/01 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - nu18193248 [pii] AID - nutrients-18-03248 [pii] AID - 10.3390/nu18193248 [doi] PST - epublish SO - Nutrients. 2026 Oct 1;18(19):3248. doi: 10.3390/nu18193248. PMID- 42884696 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 1 TI - Serum Zinc Concentrations and Dietary Zinc Adequacy in Children and Adolescents with Chronic Conditions: An Exploratory Secondary Analysis. LID - 10.3390/nu18193245 [doi] LID - 3245 AB - Background/Objectives: This secondary analysis evaluated the discordance between dietary adequacy and serum zinc levels in children and adolescents with chronic diseases, exploring the nutritional and biochemical traits of patients within an intermediate serum zinc range. Methods: Serum zinc was measured via atomic absorption spectrophotometry, and dietary tracking was conducted using a prospective 72 h food record. Subgroups were classified using Japanese Society of Clinical Nutrition thresholds (<60, 60-<80, and >/=80 mug/dL), treating the 60-<80 mug/dL band strictly as an operational, exploratory classification rather than a validated pediatric diagnostic standard. Results: Among the 90 participants, 31% fell into the 60-<80 mug/dL intermediate serum range and 61% exhibited inadequate dietary intake. Status discordance was frequent: 41% presented with inadequate dietary intake despite maintaining normal serum levels (>/=80 mug/dL), whereas 11% had intermediate serum levels despite achieving adequate dietary intake. There was no significant association between serum zinc concentration and dietary zinc intake. Operationally classified intermediate-range participants demonstrated several nutritional and biochemical differences, notably showing higher intakes of vitamins B6, D, and E, elevated triglycerides, ESR, and IgG3, alongside lower hemoglobin. Conclusions: Dietary adequacy and serum zinc levels are frequently discordant, reinforcing that these metrics serve as complementary rather than interchangeable indicators of zinc status. The distinct profiles observed within the operational 60-<80 mug/dL category provide candidate relationships that warrant future targeted investigation. FAU - Escobedo-Monge, Marlene Fabiola AU - Escobedo-Monge MF AUID- ORCID: 0000-0002-1295-3752 AD - Department of Pediatrics, Faculty of Medicine, University of Valladolid, Avenida Ramon y Cajal, 7, 47003 Valladolid, Spain. AD - International Cooperation for Health and Social Development (CIDESS) Group, University of Las Palmas de Gran Canaria, Calle Juan de Quesada, 30, 35001 Las Palmas de Gran Canaria, Spain. AD - Valladolid Health Research Institute (IBioVALL), C. Rondilla Sta. Teresa, 47010 Valladolid, Spain. FAU - Marugan-Miguelsanz, Jose Manuel AU - Marugan-Miguelsanz JM AD - Department of Pediatrics, Faculty of Medicine, University of Valladolid, Avenida Ramon y Cajal, 7, 47003 Valladolid, Spain. AD - Valladolid Health Research Institute (IBioVALL), C. Rondilla Sta. Teresa, 47010 Valladolid, Spain. AD - Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ramon y Cajal, 3, 47003 Valladolid, Spain. FAU - Parodi Roman, Joaquin AU - Parodi Roman J AD - Science Faculty, University of Cadiz, Paseo de Carlos III, 28, 11003 Cadiz, Spain. FAU - Escobedo-Monge, Maria Antonieta AU - Escobedo-Monge MA AUID- ORCID: 0000-0001-6318-7333 AD - Department of Chemistry, Science Faculty, University of Burgos, Plaza Misael Banuelos SN, 09001 Burgos, Spain. FAU - Bahillo-Curieses, M Pilar AU - Bahillo-Curieses MP AD - Department of Pediatrics, Faculty of Medicine, University of Valladolid, Avenida Ramon y Cajal, 7, 47003 Valladolid, Spain. AD - Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ramon y Cajal, 3, 47003 Valladolid, Spain. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - J41CSQ7QDS (Zinc) SB - IM MH - Humans MH - *Zinc/blood/deficiency/administration & dosage MH - Adolescent MH - Child MH - Female MH - Chronic Disease MH - Male MH - *Nutritional Status MH - *Diet MH - Prospective Studies MH - Secondary Data Analysis MH - Child, Preschool PMC - PMC13667015 OTO - NOTNLM OT - deficient zinc intake OT - low/intermediate zinc deficiency COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/01 CRDT- 2026/10/16 01:10 PHST- 2026/09/02 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - nu18193245 [pii] AID - nutrients-18-03245 [pii] AID - 10.3390/nu18193245 [doi] PST - epublish SO - Nutrients. 2026 Oct 1;18(19):3245. doi: 10.3390/nu18193245. PMID- 42884691 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 1 TI - Enteral Feeding During Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy in Neonates: A Multicentre Study from Italy and Belgium. LID - 10.3390/nu18193240 [doi] LID - 3240 AB - Background: Enteral feeding during therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy (HIE) remains heterogeneous across centres because of concerns regarding feeding intolerance and the risk of necrotizing enterocolitis (NEC). Evidence regarding optimal feeding initiation and advancement remains limited. Methods: We performed a secondary analysis of a multicentre retrospective cohort of infants with HIE treated with TH at two tertiary neonatal intensive care units in Italy and Belgium between 2011 and 2024. We included survivors with complete nutritional data, aware that this restriction, adopted because feeding-related endpoints cannot be assessed in non-survivors, may introduce survivor bias. Feeding practices, enteral feeding progression, feeding tolerance, and gastrointestinal outcomes were evaluated. Results: Of 302 infants in the original cohort, 276 were included. Enteral feeding during TH was administered to 166 infants (60.1%). Enteral feeding volumes remained low during the first three days of life but progressively increased thereafter. Despite inter-center differences in feeding strategies (initiation and advancement), time to full enteral feeding (median 9 days; IQR 7-12) was comparable overall (Italy: median 9 days, IQR 7-12; Belgium: median 10 days, IQR 7-14; p = 0.323). Infants receiving enteral nutrition during TH were observed to achieve full enteral feeding earlier than those not fed during cooling (median 8.0 vs. 12.0 days, p < 0.001) and to have a shorter length of hospital stay (median 11.0 vs. 15.0 days, p < 0.001). Breastfeeding at discharge was also observed more frequently among infants who received enteral nutrition during TH (79.5% vs. 54.5%, p < 0.001). Feeding intolerance occurred in 47 infants (17.0%) and temporary feeding withdrawal in 31 (11.2%). Only three infants (1.1%) developed Bell stage IIA NEC, with no progression to more advanced disease or surgery. NEC was more frequent among infants with Sarnat stage III HIE than among those with stage I-II disease (8.3% vs. 0.4%, p = 0.022). Conclusions: Enteral feeding during TH was feasible, and gastrointestinal complications were uncommon. These findings support the feasibility of cautious enteral feeding during TH. The concentration of NEC events among infants with severe HIE, although based on only three cases, is hypothesis-generating and suggests that future studies should evaluate feeding strategies according to both neurological severity and physiological stability. Whether earlier initiation or faster advancement is beneficial in clinically stable infants cannot be determined from these observational data and should be addressed in prospective studies. FAU - De Rose, Domenico Umberto AU - De Rose DU AUID- ORCID: 0000-0002-9076-9838 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Bersani, Iliana AU - Bersani I AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Salvatori, Guglielmo AU - Salvatori G AUID- ORCID: 0000-0001-8761-8732 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Campi, Francesca AU - Campi F AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Martini, Ludovica AU - Martini L AUID- ORCID: 0000-0002-3090-5949 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Maddaloni, Chiara AU - Maddaloni C AUID- ORCID: 0000-0002-4265-0939 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Ronci, Sara AU - Ronci S AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Santisi, Alessandra AU - Santisi A AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Savarese, Immacolata AU - Savarese I AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Auriti, Cinzia AU - Auriti C AUID- ORCID: 0000-0001-9820-6557 AD - Faculty of Medicine and Surgery, Unicamillus, Saint Camillus International University of Health and Medical Sciences, 00131 Rome, Italy. FAU - Camacho Santamaria, Elena AU - Camacho Santamaria E AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - De Groote, Anais AU - De Groote A AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - Carkeek, Katherine AU - Carkeek K AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - Iacona, Giulia AU - Iacona G AD - Faculty of Medicine, Imperial College, London SW7 2AZ, UK. FAU - Cilio, Maria Roberta AU - Cilio MR AD - Division of Child Neurology, Department of Pediatrics, Cliniques Universitaires Saint-Luc, Institute of Neuroscience (IoNS), Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - Ronchetti, Maria Paola AU - Ronchetti MP AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Braguglia, Annabella AU - Braguglia A AD - Neonatal Sub-Intensive Care Unit and Follow-Up, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Danhaive, Olivier AU - Danhaive O AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - Dotta, Andrea AU - Dotta A AUID- ORCID: 0000-0002-1260-6427 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Piersigilli, Fiammetta AU - Piersigilli F AUID- ORCID: 0000-0002-6581-2822 AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. LA - eng GR - Current Research funds/Ministero della Salute/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20261001 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Female MH - Humans MH - Infant, Newborn MH - Male MH - Belgium MH - *Enteral Nutrition/methods/adverse effects MH - Enterocolitis, Necrotizing/etiology/prevention & control MH - *Hypothermia, Induced/methods/adverse effects MH - *Hypoxia-Ischemia, Brain/therapy MH - Intensive Care Units, Neonatal MH - Italy MH - Retrospective Studies MH - Treatment Outcome PMC - PMC13666962 OTO - NOTNLM OT - breastfeeding OT - donor human milk OT - feeding tolerance OT - gastrointestinal outcomes OT - human milk OT - necrotizing enterocolitis OT - neonatal intensive care unit OT - neonatal nutrition OT - nutritional support OT - parenteral nutrition OT - perinatal asphyxia COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/01 CRDT- 2026/10/16 01:10 PHST- 2026/08/18 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - nu18193240 [pii] AID - nutrients-18-03240 [pii] AID - 10.3390/nu18193240 [doi] PST - epublish SO - Nutrients. 2026 Oct 1;18(19):3240. doi: 10.3390/nu18193240. PMID- 42884683 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 30 TI - Quality Indicators for Evaluation of Neonatal Basic Care in Nutrition and Feeding: A Scoping Review and Modified Delphi Study. LID - 10.3390/nu18193230 [doi] LID - 3230 AB - Background/Objectives: Despite the clinical relevance of nutrition and feeding in neonatal intensive care, no consensus-based set of quality indicators currently exists to systematically evaluate basic nutritional care in hospitalised neonates. This study aimed to identify, agree through expert consensus and prioritise a structured set of nursing-sensitive quality indicators for this domain. Methods: A two-phase methodological study combined a Scoping Review (Joanna Briggs Institute methodology; prospectively registered on OSF; reported per PRISMA-ScR) and a two-round modified Delphi study based on the RAND/UCLA Appropriateness Method. Four databases (PubMed, Embase, Scopus, and Cochrane Library; 2020-2025) were searched, complemented by snowball and the grey literature. Twenty-seven candidate indicators synthesised inductively into eight domains were rated by 23 expert nurses across three dimensions (appropriateness, clinical validity, and feasibility) on a nine-point Likert scale. Results: Retention from Round 1 to Round 2 was 87% (n = 20). Twenty-two indicators (81.5%) were classified as appropriate and five (18.5%) as uncertain, in all cases because of feasibility. The overall median for appropriateness and clinical validity was 9.0 in both rounds. Feasibility showed greater variability, with an 18% mean IQR reduction after Round 2. Indicators reaching consensus were distributed across structure (n = 3, 13.6%), process (n = 16, 72.7%) and outcome (n = 3, 13.6%) dimensions. An exploratory post-hoc prioritisation analysis identified four implementation tiers; the five Tier 1 indicators ranked in the top five under every weighting scheme tested. Conclusions: This consensus-based set provides a structured basis for monitoring neonatal nutritional care quality and for reducing clinical variability. Validation by a broader interdisciplinary panel including families, and prospective testing in routine practice, are required before its use in clinical dashboards or benchmarking. FAU - Buck Sainz-Rozas, Pablo AU - Buck Sainz-Rozas P AD - Health Services Research Group, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain. AD - Methodology of Biomedical Research and Public Health, Universitat Autonoma de Barcelona (UAB), 08193 Bellaterra, Spain. FAU - Osorio Sanchez, Dimelza AU - Osorio Sanchez D AD - Health Services Research Group, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain. AD - Methodology of Biomedical Research and Public Health, Universitat Autonoma de Barcelona (UAB), 08193 Bellaterra, Spain. AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Garcia Molina, Pablo AU - Garcia Molina P AUID- ORCID: 0000-0002-5900-6314 AD - Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain. AD - Department of Nursing, Universitat de Valencia, 46010 Valencia, Spain. FAU - Balaguer-Lopez, Evelin AU - Balaguer-Lopez E AUID- ORCID: 0000-0003-4204-3511 AD - Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain. AD - Department of Nursing, Universitat de Valencia, 46010 Valencia, Spain. FAU - Alonso Fernandez, Sergio AU - Alonso Fernandez S AUID- ORCID: 0000-0001-6969-9380 AD - Fundamental and Clinical Nursing Department, Nursing Faculty, University of Barcelona (UB), 08907 Barcelona, Spain. AD - Nursing Research Group (GRIN), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Spain. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260930 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Delphi Technique MH - *Quality Indicators, Health Care MH - Infant, Newborn MH - Consensus MH - *Intensive Care, Neonatal/standards MH - *Infant Nutritional Physiological Phenomena PMC - PMC13666701 OTO - NOTNLM OT - Delphi method OT - RAND/UCLA OT - breastfeeding OT - neonatal nursing OT - neonatal nutrition OT - nursing-sensitive indicators OT - patient safety OT - quality indicators COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/30 CRDT- 2026/10/16 01:10 PHST- 2026/08/14 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - nu18193230 [pii] AID - nutrients-18-03230 [pii] AID - 10.3390/nu18193230 [doi] PST - epublish SO - Nutrients. 2026 Sep 30;18(19):3230. doi: 10.3390/nu18193230. PMID- 42884672 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 29 TI - Beyond Self-Reported Adherence and Serology: Stool Gluten Immunogenic Peptides Detection to Assess Gluten Exposure in Children with Celiac Disease on a Gluten-Free Diet. LID - 10.3390/nu18193221 [doi] LID - 3221 AB - Background/Objectives: A lifelong gluten-free diet (GFD) is the only treatment for celiac disease (CD). However, current methods for monitoring GFD adherence do not accurately assess gluten exposure. Stool detection of gluten immunogenic peptides (GIP) may provide an objective tool for detecting recent gluten exposure. The aim of this study was to evaluate stool GIP detection, compared with serology and the validated Biagi dietary questionnaire, for monitoring GFD adherence in children with CD. Methods: In this prospective multicenter study, pediatric patients with CD on a GFD for at least 1 year were enrolled. Serum and stool samples were collected on the same day to assess serum anti-transglutaminase (TTG) and anti-endomysium (EMA) antibodies and stool GIP. Patients also completed the Biagi dietary questionnaire. Results: Forty-one pediatric patients with CD on a GFD for a median of 6.5 years were enrolled. Serum TTG and/or EMA were positive in 8/41 patients (19.5%), Biagi questionnaire identified 8/41 patients (19.5%) as non-adherent, whereas stool GIP was positive in 17/41 (41.5%). Combining serology with the dietary questionnaire increased the proportion of non-adherent patients to 34%. Adding stool GIP detection increased this proportion to 51% and 46% when combined with serology or the dietary questionnaire, respectively. Overall, 23/41 patients (56%) showed evidence of gluten exposure when positivity in at least one of the three methods was considered. Conclusions: A high rate of recent gluten exposure was detected in children with CD on a long-term GFD. Stool GIP detection may provide complementary information to conventional methods for monitoring GFD adherence and may help identify patients requiring further dietary assessment or intervention. FAU - Ziberna, Fabiana AU - Ziberna F AUID- ORCID: 0000-0002-9748-902X AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Fontana, Giorgia AU - Fontana G AUID- ORCID: 0000-0001-7268-4104 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Zanchi, Chiara AU - Zanchi C AUID- ORCID: 0000-0001-8513-1963 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Bobbo, Marco AU - Bobbo M AD - Department of Pediatrics, University of Trieste, 34127 Trieste, Italy. FAU - Spinelli, Elena AU - Spinelli E AUID- ORCID: 0009-0008-6102-2250 AD - Department of Medical and Surgical Sciences, University of Trieste, 34127 Trieste, Italy. FAU - Grimaldi, Maria Cristina AU - Grimaldi MC AUID- ORCID: 0000-0002-4646-0032 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Tizi, Fatima AU - Tizi F AUID- ORCID: 0009-0009-8001-3314 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Di Leo, Grazia AU - Di Leo G AUID- ORCID: 0000-0002-6313-4482 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Martelossi, Stefano AU - Martelossi S AD - Ca' Foncello Hospital, 31100 Treviso, Italy. FAU - Not, Tarcisio AU - Not T AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - De Leo, Luigina AU - De Leo L AUID- ORCID: 0000-0003-4013-1630 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. LA - eng GR - RC11/19/Ministry of Health/ PT - Journal Article PT - Multicenter Study DEP - 20260929 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 8002-80-0 (Glutens) RN - 0 (Peptides) RN - 0 (Autoantibodies) SB - IM MH - Humans MH - *Celiac Disease/diet therapy/immunology/blood MH - *Diet, Gluten-Free MH - Child MH - Female MH - *Glutens/immunology/analysis MH - *Feces/chemistry MH - Male MH - Prospective Studies MH - *Patient Compliance MH - Adolescent MH - Child, Preschool MH - *Peptides/analysis/immunology MH - Self Report MH - Surveys and Questionnaires MH - Autoantibodies/blood PMC - PMC13667095 OTO - NOTNLM OT - Biagi questionnaire OT - celiac disease OT - gluten immunogenic peptides OT - gluten-free diet COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/29 CRDT- 2026/10/16 01:10 PHST- 2026/09/08 00:00 [received] PHST- 2026/09/28 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - nu18193221 [pii] AID - nutrients-18-03221 [pii] AID - 10.3390/nu18193221 [doi] PST - epublish SO - Nutrients. 2026 Sep 29;18(19):3221. doi: 10.3390/nu18193221. PMID- 42884671 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 29 TI - The Diagnostic Elimination Diet and Challenge Protocol for Management of Patients with Food Intolerance-Purpose and Development. LID - 10.3390/nu18193220 [doi] LID - 3220 AB - Background: In the 1960s and 1970s, several authors reported that manipulation of diet by excluding certain additives and natural chemical substances led to apparent clinical benefit for patients with adverse food reactions involving the skin, gastrointestinal tract, respiratory tract, and central nervous system. Methods: Over the past 48 years, patients of all ages presenting to the Royal Prince Alfred Hospital Allergy Unit with adverse food reactions were offered an elimination diet low in natural salicylates, biogenic amines, and glutamate, and free of additives such as preservatives and colors, for two to six weeks. Those who became asymptomatic were offered testing with a "N-of-1" double-blind, placebo-controlled (DBPC) challenge protocol. Results: There were 14,119 patients who elected to undertake either the strict elimination diet (10,074) (71.4%), the moderate approach (2760) (19.5%), or the simple approach (1285) (9.1%). Of these, 6645 (47.1%) became asymptomatic within two to six weeks; 628 (4.4%) reported no improvement; and 6846 (48.5%) were lost to follow-up. Of those who improved, 4963 (35.2%) returned for interpretation of their challenges, and 2429 had undertaken open food challenges; 3326 had completed the DBPC capsule challenge protocol, and 1830 completed both DBPC capsule and food challenges. Although individual reactivity was idiosyncratic, a highly reproducible pattern was evident across the entire group. The proportion reacting to each of the active chemical challenges versus placebo was highly significant (p < 0.001). Conclusions: In many patients with food intolerance, idiosyncratic dietary triggers can be reliably identified with a standardized elimination diet and DBPC challenge protocol. Long-term symptom control can be achieved by appropriate dietary modification. FAU - Swain, Anne AU - Swain A AUID- ORCID: 0009-0006-9729-5360 AD - Department of Clinical Immunology & Allergy, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. AD - Department of Nutrition & Dietetics, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. FAU - Malinao, Jo Ann AU - Malinao JA AD - Department of Clinical Immunology & Allergy, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. AD - Department of Nutrition & Dietetics, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. FAU - Soutter, Velencia AU - Soutter V AD - Department of Clinical Immunology & Allergy, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. FAU - Loblay, Robert AU - Loblay R AUID- ORCID: 0000-0002-7369-0853 AD - Department of Clinical Immunology & Allergy, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Elimination Diets MH - *Food Intolerance/diet therapy/diagnosis MH - *Food Hypersensitivity/diet therapy/diagnosis MH - Child MH - Female MH - Double-Blind Method MH - Male MH - Adolescent MH - Adult PMC - PMC13666893 OTO - NOTNLM OT - biogenic amine OT - challenge OT - color OT - elimination diet OT - food intolerance OT - glutamate OT - gluten OT - milk OT - preservative OT - salicylate OT - wheat COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/29 CRDT- 2026/10/16 01:10 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - nu18193220 [pii] AID - nutrients-18-03220 [pii] AID - 10.3390/nu18193220 [doi] PST - epublish SO - Nutrients. 2026 Sep 29;18(19):3220. doi: 10.3390/nu18193220. PMID- 42884631 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 26 TI - Dietary Management of IgE-Mediated and Non-IgE-Mediated Food Allergies: A Systematic Review of Current Evidence and Clinical Implications. LID - 10.3390/nu18193180 [doi] LID - 3180 AB - BACKGROUND: Food allergy is an increasing global health problem associated with substantial clinical, nutritional, and psychosocial burden. METHODS: This systematic review was conducted according to the PRISMA 2020 Statement. PubMed/MEDLINE and Scopus were systematically searched for studies published between January 2016 and December 2025. A total of 218 records were identified, of which 180 were screened after duplicate removal; 14 studies met the predefined eligibility criteria and were included in the qualitative synthesis. Methodological quality was assessed using validated appraisal tools according to study design, and findings were synthesized narratively following the SWIM guideline. RESULTS: Avoidance of confirmed culprit foods remains a central component of food allergy management, although prolonged or unnecessarily restrictive elimination may adversely affect dietary diversity, nutritional adequacy, growth, and quality of life, particularly in children and patients with multiple food allergies. Randomized controlled trials and systematic reviews support early allergen introduction for prevention of IgE-mediated food allergies and oral immunotherapy as an active treatment option in selected patients with IgE-mediated food allergies, although treatment-related adverse events remain an important consideration. In contrast, evidence supporting several dietary management strategies for non-IgE-mediated food allergies is more frequently derived from observational studies and evidence-based recommendations, highlighting important gaps in the current evidence base. CONCLUSIONS: Current evidence supports individualized dietary management based on regular reassessment, nutritional monitoring, supervised food reintroduction when clinically appropriate, and multidisciplinary care. The evidence supporting different dietary strategies remains heterogeneous, particularly for non-IgE-mediated food allergies, emphasizing the need for further high-quality research. FAU - Gratacos Gomez, Alejandro Raul AU - Gratacos Gomez AR AUID- ORCID: 0000-0002-9456-5760 AD - Servicio de Endocrinologia y Nutricion del Hospital Universitario de Toledo, 45071 Toledo, Spain. FAU - Iniesta Tejera, Esther AU - Iniesta Tejera E AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. FAU - Bas Bellver, Laura AU - Bas Bellver L AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. FAU - Pablo, Sergio Serrano de AU - Pablo SS AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. FAU - Clar Castello, Miriam AU - Clar Castello M AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. FAU - Gomez Torrijos, Elisa AU - Gomez Torrijos E AUID- ORCID: 0000-0002-4532-2498 AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20260926 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 37341-29-0 (Immunoglobulin E) RN - 0 (Allergens) SB - IM MH - Humans MH - *Food Hypersensitivity/immunology/diet therapy MH - *Immunoglobulin E/immunology MH - Child MH - Elimination Diets MH - Child, Preschool MH - Quality of Life MH - Allergens/immunology MH - Female MH - Male PMC - PMC13666680 OTO - NOTNLM OT - IgE-mediated food allergy OT - dietary management OT - elimination diet OT - food allergy OT - non-IgE-mediated food allergy OT - nutrition OT - oral immunotherapy OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/26 CRDT- 2026/10/16 01:10 PHST- 2026/07/10 00:00 [received] PHST- 2026/09/23 00:00 [revised] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/26 00:00 [pmc-release] AID - nu18193180 [pii] AID - nutrients-18-03180 [pii] AID - 10.3390/nu18193180 [doi] PST - epublish SO - Nutrients. 2026 Sep 26;18(19):3180. doi: 10.3390/nu18193180. PMID- 42884617 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 25 TI - Evaluation of a Wearable Hydration Monitor for Estimating Sweat Loss and Hydration Status in Collegiate Athletes: A Pilot Study. LID - 10.3390/nu18193166 [doi] LID - 3166 AB - BACKGROUND/OBJECTIVE: Instantaneous, accurate assessment of hydration and sweat loss has potential to optimize athlete performance and reduce risks associated with excessive exercise-related fluid loss. Reusable wearable hydration monitors, such as hDrop monitors, are an emerging non-invasive, quick, and easy to use alternative to existing methods. PURPOSE: To assess the accuracy of the hDrop wearable sweat monitors for estimating sweat loss and hydration status compared to established field-based measures, including body mass change and urine indices. METHODS: Division I male collegiate soccer athletes contributed repeated training-session observations (38 total observations; 18 complete observations for sweat-loss analyses and 36 for hydration-score-USG analyses). They completed training sessions during which pre- and post-exercise body mass, fluid intake, urine output, and urine samples were collected. Sweat loss was calculated using changes in body mass adjusted for fluid balance. hDrop-derived estimates of sweat loss and hydration status were compared to criterion measures using mean bias, percent of criterion, mean absolute percent error (MAPE), repeated-measures Bland-Altman analysis, and generalized estimating equations accounting for observations clustered within athletes. Associations between hydration scores and urine-based markers were assessed using generalized estimating equations accounting for observations clustered within athletes. RESULTS: The hDrop generated a sweat-loss estimate for 18 of 38 training-session observations (47.4%). Repeated-measures mean bias for sweat loss was -0.423 L (95% CI -1.106 to 0.259 L). The hDrop estimates averaged 106.2 +/- 64.8% of criterion while MAPE was 50.3%, reflecting large individual error. In the repeated-measures analysis, criterion-measured sweat loss was positively associated with hDrop-estimated sweat loss (B = 0.204, 95% CI 0.018 to 0.391, p = 0.032). Significant proportional bias was present (slope = -0.790, 95% CI -1.438 to -0.143, p = 0.020), indicating greater underestimation at higher sweat-loss values. In repeated-measures GEE analyses, USG was not significantly associated with the hDrop hydration score either before practice (B = -407.9, 95% CI -1008.7 to 192.8, p = 0.183) or after practice (B = -135.0, 95% CI -803.8 to 533.7, p = 0.692). CONCLUSIONS: The hDrop generated sweat-loss estimates in fewer than half of training-session observations and demonstrated substantial individual-level error and significant proportional bias when estimates were available. Although the instantaneous hydration score decreased following exercise, its lack of association with USG leaves its physiological meaning and criterion validity uncertain. These findings do not support use of the hDrop as an interchangeable substitute for established methods of individualized sweat-loss or hydration assessment. FAU - Snyder, Jill McCann AU - Snyder JM AUID- ORCID: 0009-0000-4031-3763 AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Toth, Lindsay AU - Toth L AUID- ORCID: 0000-0001-5856-2012 AD - Department of Clinical and Applied Movement Sciences, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Aguero, Elysse AU - Aguero E AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Brennan, Colleen AU - Brennan C AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Duarte, Kassandra AU - Duarte K AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. LA - eng GR - Brooks College of Health Pilot Research Grant/ PT - Journal Article DEP - 20260925 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Pilot Projects MH - *Wearable Electronic Devices MH - *Athletes MH - *Sweating/physiology MH - Young Adult MH - *Organism Hydration Status MH - *Dehydration/diagnosis MH - Water-Electrolyte Balance MH - Sweat MH - Monitoring, Physiologic/instrumentation MH - Adolescent MH - Drinking MH - Reproducibility of Results MH - Soccer MH - Exercise/physiology PMC - PMC13666982 OTO - NOTNLM OT - hydration assessment OT - sweat loss OT - validity COIS- hDrop Technologies Inc. donated the wearable monitors used in this study. The company had no role in the study design; collection, analysis, or interpretation of the data; preparation of the manuscript; or decision to submit the manuscript for publication. hDrop Technologies Inc. did not have access to the raw study data before manuscript preparation or submission. The authors declare no other conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/25 CRDT- 2026/10/16 01:10 PHST- 2026/08/04 00:00 [received] PHST- 2026/09/19 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - nu18193166 [pii] AID - nutrients-18-03166 [pii] AID - 10.3390/nu18193166 [doi] PST - epublish SO - Nutrients. 2026 Sep 25;18(19):3166. doi: 10.3390/nu18193166. PMID- 42884610 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 25 TI - Nutritional Accuracy and Clinical Applicability of Large Language Model-Generated Therapeutic Diet Plans for Phenylketonuria: A Comparative Simulation Study. LID - 10.3390/nu18193158 [doi] LID - 3158 AB - Background: Large language models (LLMs) are increasingly used to generate nutrition-related recommendations, but their reliability for therapeutic diets requiring precise nutrient control remains uncertain. This study evaluated AI-generated one-day diet plans for standardized simulated cases of classical phenylketonuria (PKU). Methods: Eight standardized simulated cases representing infancy, adolescence, adulthood, and maternal PKU were evaluated. Between 8 and 10 February 2026, ChatGPT-5.2, Claude 4.5, and Gemini 3 were each used through their standard consumer-facing chat interfaces to generate one diet plan per case under two prompting conditions, yielding 48 plans. Nutrient composition was independently recalculated using BIAYS, and three blinded pediatric metabolic dietitians evaluated the plans using a structured 25-item checklist. Results: Across all 48 plans, phenylalanine provision calculated using BIAYS was below the case-specific prescription in 36 plans (75.0%). After Holm correction, none of the 12 paired AI-reported versus BIAYS-calculated nutrient comparisons remained statistically significant, while plan-level error metrics demonstrated substantial variability for several nutrients. Overall expert scores did not differ among models, whereas clinically specified structured prompts received higher expert ratings than limited-information zero-shot prompts. Inter-rater reliability was modest at the diet-plan level. Conclusions: AI-generated PKU diet plans may incorporate core dietary principles, but numerical plausibility does not ensure agreement with independent nutrient calculations or adherence to individualized clinical prescriptions. Independent nutrient verification and specialist metabolic-dietitian review remain necessary. Because only one output was generated for each case-model-prompt combination, the findings characterize the 48 evaluated outputs rather than within-model reproducibility. FAU - Kulu, Bahar AU - Kulu B AD - Division of Inherited Metabolic Disorders, University of Health Sciences, Tepecik Training and Research Hospital, Izmir 35170, Turkiye. FAU - Suzen, Banu AU - Suzen B AUID- ORCID: 0000-0002-5975-5868 AD - Department of Nutrition and Dietetics, School of Health Sciences, Cappadocia University, Nevsehir 50420, Turkiye. FAU - Mintas, Nuriye Ece AU - Mintas NE AUID- ORCID: 0000-0002-0033-6861 AD - Division of Inherited Metabolic Disorders, Mugla Training and Research Hospital, Mugla 48000, Turkiye. FAU - Sahin Uyar, Sibel Burcak AU - Sahin Uyar SB AD - Division of Inherited Metabolic Disorders, Izmir City Hospital, Izmir 35530, Turkiye. FAU - Ozcan, Esra AU - Ozcan E AUID- ORCID: 0009-0009-9393-143X AD - Department of Nutrition and Dietetics, Izmir City Hospital, Izmir 35530, Turkiye. FAU - Durgun, Fulya AU - Durgun F AUID- ORCID: 0009-0005-1365-2475 AD - Department of Nutrition and Dietetics, Tepecik Training and Research Hospital, Izmir 35180, Turkiye. FAU - Tatlidil, Neslihan Buse AU - Tatlidil NB AUID- ORCID: 0009-0002-0059-178X AD - Department of Nutrition and Dietetics, Tepecik Training and Research Hospital, Izmir 35180, Turkiye. FAU - Arslan, Nur AU - Arslan N AD - Division of Inherited Metabolic Disorders, Faculty of Medicine, Dokuz Eylul University, Izmir 35340, Turkiye. AD - Izmir Biomedicine and Genome Center (IBG), Izmir 35340, Turkiye. FAU - Hanci, Volkan AU - Hanci V AUID- ORCID: 0000-0002-2227-194X AD - Department of Anesthesiology and Reanimation, Division of Intensive Care, Faculty of Medicine, Dokuz Eylul University, Izmir 35340, Turkiye. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260925 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 47E5O17Y3R (Phenylalanine) SB - IM MH - *Phenylketonurias/diet therapy MH - Humans MH - *Large Language Models MH - Reproducibility of Results MH - Female MH - Adolescent MH - Infant MH - Child MH - Adult MH - Computer Simulation MH - Phenylalanine/blood MH - *Diet Therapy/methods PMC - PMC13667255 OTO - NOTNLM OT - artificial intelligence OT - clinical nutrition OT - diet planning OT - large language models OT - phenylketonuria OT - therapeutic diet COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/25 CRDT- 2026/10/16 01:10 PHST- 2026/08/25 00:00 [received] PHST- 2026/09/20 00:00 [revised] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - nu18193158 [pii] AID - nutrients-18-03158 [pii] AID - 10.3390/nu18193158 [doi] PST - epublish SO - Nutrients. 2026 Sep 25;18(19):3158. doi: 10.3390/nu18193158. PMID- 42884600 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 24 TI - Too Wordy, Too Long and Too Cluttered: User Acceptance Testing, Co-Design, and Early Beta Testing to Adapt the Daily Health Coach for Young Australian Women. LID - 10.3390/nu18193150 [doi] LID - 3150 AB - Background/Objectives: The Daily Health Coach (DHC) is a 12-week Instagram-based nutrition and wellbeing programme originally co-designed and tested in New Zealand to deliver evidence-based, weight-neutral content on nutrition, movement, body image, and wellbeing. This formative, mixed-methods adaptation study examined the acceptability of DHC New Zealand content for young Australian women and identified refinements to improve relevance, engagement, and safety before effectiveness evaluation. Methods: Using the CODES framework, we conducted three adaptation phases: user acceptance testing, co-design workshops, and early beta testing. Following data-quality screening, 291 young women aged 18-24 years who completed all 12 survey sections were included in Phase 1. Participants rated 84 Instagram-style posts for understanding and usefulness and provided open-ended feedback. Twelve young women participated in co-design workshops, and seven adapted artefacts were beta-tested with eight target users using cognitive walkthrough and think-aloud methods. Quantitative findings were examined descriptively, with sensitivity analyses undertaken to assess robustness to response-quality and sample-composition concerns. Results: Participant-level mean understanding was 3.99 +/- 0.75/5, usefulness was 3.89 +/- 0.74/5, and the combined score was 7.87 +/- 1.47/10. Post-level combined means ranged from 7.66 to 8.11/10; all 84 posts met a >/=7.5 descriptive benchmark adapted from prior message-testing work, although this is an interpretive aid rather than a validated cut-off. Sensitivity analyses showed a similar overall pattern: ratings were higher in a higher-confidence response-quality sample (n = 199; 8.34 +/- 1.20/10), while four posts fell marginally below 7.5 when analysis was restricted to participants not reporting Aboriginal and/or Torres Strait Islander identity (n = 101). Qualitative feedback identified six refinement areas: content features, engagement strategies, clarity, educational accuracy, relevance, and miscellaneous concerns. Co-design and beta testing generated four adaptation priorities: tone, design, engagement, and understanding. Conclusions: DHC New Zealand content was generally well understood and favourably rated but required targeted refinement for the Australian context. Findings provide formative guidance for final adaptation and subsequent effectiveness evaluation. FAU - Roy, Rajshri AU - Roy R AUID- ORCID: 0000-0002-7939-1790 AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia. FAU - Hamilton, Isabella AU - Hamilton I AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. FAU - Khan, Demera AU - Khan D AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. FAU - Issa, Mariah AU - Issa M AUID- ORCID: 0009-0001-2512-9332 AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia. AD - School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. FAU - Alami, Jasmin AU - Alami J AUID- ORCID: 0009-0002-5323-724X AD - TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany. FAU - Malloy, Jessica A AU - Malloy JA AUID- ORCID: 0000-0002-5569-1019 AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. LA - eng GR - The University of Sydney/ PT - Journal Article DEP - 20260924 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - Australia MH - Young Adult MH - New Zealand MH - *Health Promotion/methods MH - Surveys and Questionnaires MH - *Social Media PMC - PMC13667190 OTO - NOTNLM OT - body image OT - co-design OT - cultural adaptation OT - digital health OT - health promotion OT - nutrition OT - social media OT - usability testing OT - user acceptance testing OT - young women COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/24 CRDT- 2026/10/16 01:10 PHST- 2026/07/22 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - nu18193150 [pii] AID - nutrients-18-03150 [pii] AID - 10.3390/nu18193150 [doi] PST - epublish SO - Nutrients. 2026 Sep 24;18(19):3150. doi: 10.3390/nu18193150. PMID- 42884589 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - The Gut-Skin Axis in Pediatric Atopic Dermatitis: Nutritional Modulation, Microbiome Interactions, and Emerging Precision Approaches. LID - 10.3390/nu18193138 [doi] LID - 3138 AB - BACKGROUND/OBJECTIVES: Pediatric atopic dermatitis (AD) is a barrier-driven inflammatory skin disease with systemic immune and microbial correlates. The gut-skin axis offers a biologically plausible framework through which early-life nutrition, gut microbial metabolism, intestinal barrier function, and immune maturation may influence disease risk and expression, but much of the supporting evidence remains associative. This narrative review asks which nutritional strategies are supported by clinical evidence in children with AD, which remain investigational, and how far the field is from precision nutrition. METHODS: PubMed/MEDLINE, Scopus, and Web of Science were searched up to 31 July 2026; guidelines, systematic reviews, randomized trials, birth cohorts, and mechanistic studies with pediatric relevance were prioritized and appraised narratively. RESULTS: Breastfeeding when possible, dietary diversity during complementary feeding, avoidance of unnecessary elimination diets, correction of documented nutritional deficiencies, and management of confirmed food allergy are supported by current guidance. Probiotics and synbiotics lower SCORAD in meta-analyses, but the pooled effect is small, heterogeneous, and below the minimal clinically important difference, so they are best described as an optional adjunct rather than a recommended treatment; Mediterranean-style or high-fiber dietary patterns are backed mainly by observational data. Microbiome profiling, metabolomics, multi-omics endotyping, and artificial intelligence remain research tools without validated predictive value for dietary responses. CONCLUSIONS: Nutrition is an adjunct to, not a substitute for, established topical and systemic therapy in pediatric AD. Precision nutrition is a promising research direction rather than an established component of routine care, and its clinical value will depend on standardized biomarkers and well-designed longitudinal and interventional studies. FAU - Miulescu, Raluca-Gabriela AU - Miulescu RG AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. AD - Saint Constantin Hospital, 500388 Brasov, Romania. FAU - Costescu, Mihnea AU - Costescu M AUID- ORCID: 0000-0002-3678-7584 AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. FAU - Marin, Ruxandra-Cristina AU - Marin RC AUID- ORCID: 0000-0002-3182-1683 AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. FAU - Musetescu, Alina AU - Musetescu A AD - Department of Dermatology, "Dr. Victor Babes" Clinical Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania. AD - Department of Dermatology, "Titu Maiorescu" University, 031593 Bucharest, Romania. FAU - Muntean, Calin AU - Muntean C AUID- ORCID: 0000-0002-0497-0405 AD - Department III Functional Science, Discipline of Medical Informatics and Biostatistics, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. FAU - Rosca, Ioana AU - Rosca I AUID- ORCID: 0009-0002-4629-5820 AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. AD - Pediatrics Department, National Institute for Mother and Child Health "Alessandrescu-Rusescu", 20382 Bucharest, Romania. FAU - Adam, Iris-Iuliana AU - Adam II AD - Saint Constantin Hospital, 500388 Brasov, Romania. FAU - Ilici, Alina AU - Ilici A AD - Adeomed Clinic, 061344 Bucharest, Romania. FAU - Coman, Oana Andreia AU - Coman OA AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Gastrointestinal Microbiome/physiology MH - *Skin/microbiology MH - *Dermatitis, Atopic/complications/microbiology/therapy MH - Intestinal Barrier Function MH - *Child Nutritional Physiological Phenomena/physiology MH - *Precision Medicine/methods MH - Probiotics/administration & dosage MH - Diet MH - Dysbiosis/complications/microbiology/therapy MH - Humans MH - Child PMC - PMC13667208 OTO - NOTNLM OT - biomarkers OT - gut microbiome OT - gut-skin axis OT - microbial metabolites OT - nutrition OT - pediatric atopic dermatitis OT - precision nutrition OT - probiotics COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/08/23 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193138 [pii] AID - nutrients-18-03138 [pii] AID - 10.3390/nu18193138 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3138. doi: 10.3390/nu18193138. PMID- 42884588 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - Host-Microbiota Interactions in Adolescents with Severe Anorexia Nervosa: Linking Gut Dysbiosis, Intestinal Barrier Function and Microbial Metabolism. LID - 10.3390/nu18193136 [doi] LID - 3136 AB - BACKGROUND: Anorexia nervosa (AN) is increasingly recognized as a multisystem disorder involving complex host-microbiota interactions, yet prospective pediatric studies with a comprehensive, longitudinal characterization of host-microbiota interactions remain scarce. METHODS: In this prospective longitudinal study, 26 adolescents with severe AN were evaluated at hospital admission (T0), after one month (T1), and after three months of inpatient nutritional rehabilitation (T2). Gut microbiota composition was assessed by 16S rRNA sequencing and compared with healthy controls (HC) at the baseline; predicted functional profiling was performed using PICRUSt2. Serum and urinary biomarkers of intestinal barrier integrity and microbial metabolism, routine clinical and biochemical parameters, and psychometric scores (CDI-2, MASC-2) were evaluated longitudinally using linear mixed-effects models. RESULTS: At the baseline, adolescents with AN showed reduced bacterial richness compared with healthy controls, with significantly lower Chao1 diversity (p = 0.00013), whereas the Shannon and Simpson indices did not differ significantly (p = 0.54 and p = 0.27, respectively). Microbial community composition differed significantly between groups based on Bray-Curtis (R(2) = 0.0724, FDR-adjusted p = 0.001) and unweighted UniFrac (R(2) = 0.0540, FDR-adjusted p = 0.001) distances. LEfSe identified 19 differentially abundant taxa; among the strongest discriminators, Blautia_A_141781, Romboutsia_B, and Clostridium_T were enriched in AN, whereas Akkermansia, Phocaeicola_A_858004, and Bacteroides_H were enriched in the healthy controls. Nutritional rehabilitation was associated with partial microbiota remodeling, alongside significant improvements in BMI and heart rate. Several host-derived biomarkers, including urinary indican, serotonin, nitric oxide, and serum occludin, changed significantly over time, whereas bile acids, short-chain fatty acids, IgA, lipopolysaccharide, and haptoglobin remained stable. CONCLUSIONS: Gut microbiota and host-derived biomarkers evolve dynamically during nutritional rehabilitation in adolescents with severe AN, supporting their potential role as complementary tools for monitoring biological recovery. FAU - Gargiullo, Livia AU - Gargiullo L AUID- ORCID: 0000-0003-0316-6359 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Del Chierico, Federica AU - Del Chierico F AUID- ORCID: 0000-0002-4204-4736 AD - Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Marchili, Maria Rosaria AU - Marchili MR AUID- ORCID: 0000-0002-6787-8198 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Irrera, Mariangela AU - Irrera M AUID- ORCID: 0009-0002-3274-9756 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Pretelli, Italo AU - Pretelli I AD - Anorexia and Eating Disorders Unit, Child and Adolescent Psychiatry, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Scanu, Matteo AU - Scanu M AUID- ORCID: 0000-0001-6266-2884 AD - Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Toto, Francesca AU - Toto F AD - Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Grandin, Annalisa AU - Grandin A AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Marotta, Rosaria AU - Marotta R AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Mascolo, Cristina AU - Mascolo C AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Cirillo, Flavia AU - Cirillo F AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Colistra, Valentina AU - Colistra V AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Ricci, Ludovica AU - Ricci L AD - Pediatrics Residency Program, Department of Pediatrics, University of Rome Tor Vergata, 00133 Rome, Italy. FAU - Zanna, Valeria AU - Zanna V AD - Anorexia and Eating Disorders Unit, Child and Adolescent Psychiatry, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Putignani, Lorenza AU - Putignani L AUID- ORCID: 0000-0003-0134-2830 AD - Department of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, Italy. AD - Unit of Microbiomics and Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Villani, Alberto AU - Villani A AUID- ORCID: 0000-0002-9120-0424 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. AD - Systems Medicine Departments, University of Rome Tor Vergata, 00133 Rome, Italy. LA - eng GR - RC2025_IMMUNO_GARGIULLO, RC2025_INNOV_DELCHIERICO/Ministry of Health/ PT - Journal Article DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Anorexia Nervosa/microbiology MH - Adolescent MH - Female MH - Intestinal Barrier Function MH - *Dysbiosis/microbiology MH - Prospective Studies MH - *Gastrointestinal Microbiome/physiology MH - Longitudinal Studies MH - Biomarkers/blood/urine MH - RNA, Ribosomal, 16S MH - Bacteria/classification/metabolism MH - Male PMC - PMC13666687 OTO - NOTNLM OT - anorexia nervosa OT - biomarkers OT - gut microbiota OT - gut-brain axis OT - intestinal permeability OT - nutritional rehabilitation COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/08/13 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193136 [pii] AID - nutrients-18-03136 [pii] AID - 10.3390/nu18193136 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3136. doi: 10.3390/nu18193136. PMID- 42884584 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - The Effect of a Fortified Date Bar on Perceived Stress and Morning Salivary Cortisol in Female Students: A Pilot Randomized Controlled Trial. LID - 10.3390/nu18193134 [doi] LID - 3134 AB - Background/Objectives: Chronic stress poses a serious threat to public health and is associated with the rising global burden of mental disorders, including anxiety and depression. University students, particularly young women, represent a highly vulnerable group due to the combination of academic pressure, social adaptation challenges, and gender-specific stress reactivity. This pilot randomized controlled parallel-group trial aimed to evaluate the effect of a 4-week daily consumption of a date bar fortified with magnesium (240 mg), vitamin C (300 mg), inulin (1000 mg), and grape seed extract (100 mg) on perceived stress and morning salivary cortisol in healthy female university students under natural academic load. Methods: Thirty healthy female students (aged 18-28 years) were randomized in a 1:1 ratio to either the intervention group (fortified date bar) or the control group (placebo bar) for 4 weeks. The primary outcome was the change in morning salivary cortisol levels (measured 30-60 min after awakening), and the secondary outcome was the change in perceived stress assessed by the Perceived Stress Scale (PSS-14). Measurements were performed at baseline and within 24-48 h after the intervention. Adherence was monitored via daily digital reports and weekly in-person meetings. Statistical analysis was performed using non-parametric tests (Mann-Whitney U test, Wilcoxon test) with effect sizes (rank-biserial correlation, r). Per-protocol analysis was applied for the primary outcome (n = 28) and available-case analysis for the secondary outcome (n = 29). Participants and outcome assessors were blinded to group allocation throughout the study. Results: No adverse events were reported. Median adherence was 100% in both groups, with all participants demonstrating >/= 90% compliance. No statistically significant changes in morning salivary cortisol were observed within or between groups (within-group: p = 0.173 in the intervention group, p = 0.326 in the control group; between-group: p = 0.104), although a consistent trend toward a reduction was observed in the intervention group (median Delta = -0.64 ng/mL) with a moderate effect size (r = 0.43 within-group; r = -0.37 between-group). For perceived stress, a statistically significant reduction in PSS-14 scores was observed within the intervention group (median Delta = -4.0 points; p = 0.009) with a large effect size (r = 0.80), while no significant change occurred in the control group (p = 0.624). Between-group comparison for PSS-14 changes did not reach statistical significance (p = 0.073), although the effect size was moderate (r = -0.40). No significant correlation was found between changes in cortisol and changes in PSS-14 scores (rho = -0.134; p = 0.496). Conclusions: In this pilot randomized controlled trial, four-week consumption of a fortified date bar was associated with a reduction in perceived stress among healthy female university students, as reflected by a large within-group effect size on PSS-14 scores. However, given the exploratory nature of the study, the small sample size, and the absence of an a priori power calculation, this finding should be regarded as preliminary and hypothesis-generating rather than as evidence of established efficacy. A consistent, albeit non-significant, trend toward reduced morning cortisol was also observed, suggesting a possible modulatory effect on the HPA axis that requires confirmation in larger, longer-term studies with optimized dosages. The dissociation between subjective and objective stress measures underscores the multidimensional nature of the stress response and supports the use of complementary assessment approaches in future research. The fortified date bar may warrant further investigation as a potentially feasible, acceptable, and economically accessible component of primary stress prevention strategies in young populations, although this possibility remains to be tested in adequately powered confirmatory trials. FAU - Klein, Evgeniya AU - Klein E AUID- ORCID: 0000-0003-0322-036X AD - Department of Food Technology and Bioengineering, Plekhanov Russian University of Economics, 36 Stremyanny per., 115054 Moscow, Russia. FAU - Velina, Daria AU - Velina D AUID- ORCID: 0000-0002-2398-3375 AD - Department of Food Technology and Bioengineering, Plekhanov Russian University of Economics, 36 Stremyanny per., 115054 Moscow, Russia. FAU - Mutallibzoda, Sherzodkhon AU - Mutallibzoda S AUID- ORCID: 0000-0003-3855-9494 AD - Department of Food Technology and Bioengineering, Plekhanov Russian University of Economics, 36 Stremyanny per., 115054 Moscow, Russia. FAU - Tefikova, Svetlana AU - Tefikova S AUID- ORCID: 0000-0001-9086-0781 AD - Department of Food Technology and Bioengineering, Plekhanov Russian University of Economics, 36 Stremyanny per., 115054 Moscow, Russia. FAU - Orlovtseva, Olga AU - Orlovtseva O AUID- ORCID: 0000-0002-3796-1679 AD - Department of Food Technology and Bioengineering, Plekhanov Russian University of Economics, 36 Stremyanny per., 115054 Moscow, Russia. FAU - Lebedeva, Natalia AU - Lebedeva N AUID- ORCID: 0000-0003-4936-7498 AD - Department of Innovative Technologies of Plant-Based Products, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), Zemlyanoy Val, 73, 109004 Moscow, Russia. FAU - Nikitin, Igor AU - Nikitin I AUID- ORCID: 0000-0002-8988-5911 AD - Department of Food Technology and Bioengineering, Plekhanov Russian University of Economics, 36 Stremyanny per., 115054 Moscow, Russia. AD - Department of Biotechnology of Food Products from Plant and Animal Raw Materials, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), Zemlyanoy Val, 73, 109004 Moscow, Russia. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - WI4X0X7BPJ (Hydrocortisone) RN - I38ZP9992A (Magnesium) RN - 9005-80-5 (Inulin) RN - PQ6CK8PD0R (Ascorbic Acid) SB - IM MH - Humans MH - Female MH - *Hydrocortisone/metabolism/analysis MH - Pilot Projects MH - *Saliva/chemistry/metabolism MH - Young Adult MH - Adult MH - Adolescent MH - Subjective Stress MH - *Students/psychology MH - *Food, Fortified MH - *Stress, Psychological MH - Magnesium/administration & dosage MH - Inulin/administration & dosage MH - Ascorbic Acid/administration & dosage MH - Universities PMC - PMC13666595 OTO - NOTNLM OT - HPA axis OT - date bar OT - fortified food OT - magnesium OT - nutritional intervention OT - perceived stress OT - randomized controlled trial OT - salivary cortisol OT - university students OT - vitamin C COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/07/14 00:00 [received] PHST- 2026/09/15 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193134 [pii] AID - nutrients-18-03134 [pii] AID - 10.3390/nu18193134 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3134. doi: 10.3390/nu18193134. PMID- 42884577 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - Dietary and Fluid-Intake Habits in Patients with Various Types of Urinary Incontinence: A Preliminary Study. LID - 10.3390/nu18193127 [doi] LID - 3127 AB - Background/Objectives: Urinary incontinence (UI) is common in women, particularly during and after the menopausal transition, and may both influence and be influenced by dietary and fluid-intake behaviours. This exploratory study described self-reported dietary and fluid-intake habits in women with different UI subtypes and explored their associations with pelvic floor symptom burden and self-reported fluid restriction. Energy and nutrient intake was not quantified. Methods: This exploratory, cross-sectional, single-centre study included 87 women aged 18-84 years with stress (SUI; n = 23), urgency (UUI; n = 21), or mixed (MUI; n = 43) UI, who reported UI at least weekly. Participants completed a custom dietary and fluid-intake questionnaire, the Incontinence Quality of Life Questionnaire (I-QOL), and the Pelvic Floor Distress Inventory-20 (PFDI-20). Associations were assessed using rank correlations and proportional-odds ordinal logistic regression, with Benjamini-Hochberg correction used to address multiplicity in exploratory item-level analyses. Results: No individual diet-PFDI association remained statistically significant after Benjamini-Hochberg correction across the complete 100-test matrix. In the adjusted model, an urgency component was associated with greater self-reported fluid restriction (adjusted cumulative OR = 2.92; 95% CI, 1.18-7.20), whereas each 10-year increase in age was associated with lower odds of greater restriction (adjusted cumulative OR = 0.68; 95% CI, 0.51-0.92). Conclusions: Greater self-reported fluid restriction was independently associated with an urgency component and with younger age, whereas no individual dietary or fluid-intake item remained statistically significant after correction for multiple comparisons. Given the potential risk of the practice, these findings support asking women with urgency symptoms about fluid restriction during clinical consultations. Prospective studies using a validated quantitative dietary instrument are needed to determine whether dietary and fluid-intake habits affect pelvic floor symptom burden. FAU - Piatek, Aleksandra AU - Piatek A AUID- ORCID: 0000-0002-5887-817X AD - Department of Gynecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, 50-233 Wroclaw, Poland. FAU - Kolodynska, Gabriela AU - Kolodynska G AUID- ORCID: 0000-0001-7921-7058 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland. FAU - Nowak, Krzysztof AU - Nowak K AUID- ORCID: 0000-0002-2230-9012 AD - Department of Gynecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, 50-233 Wroclaw, Poland. FAU - Drapala, Jaroslaw AU - Drapala J AUID- ORCID: 0000-0002-7251-9595 AD - Faculty of Information and Communication Technology, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland. FAU - Fink-Lwow, Felicja AU - Fink-Lwow F AUID- ORCID: 0000-0002-4323-7134 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland. FAU - Andrzejewski, Waldemar AU - Andrzejewski W AUID- ORCID: 0000-0002-0010-3021 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland. FAU - Zalewski, Maciej AU - Zalewski M AUID- ORCID: 0000-0002-0924-6870 AD - Department of Gynecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, 50-233 Wroclaw, Poland. LA - eng PT - Journal Article DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Aged MH - Adult MH - Cross-Sectional Studies MH - Aged, 80 and over MH - Adolescent MH - Young Adult MH - Quality of Life MH - *Diet MH - *Urinary Incontinence/physiopathology MH - Surveys and Questionnaires MH - *Feeding Behavior MH - *Drinking MH - *Drinking Behavior MH - Urinary Incontinence, Stress PMC - PMC13666888 OTO - NOTNLM OT - PFDI-20 OT - dietary habits OT - fluid intake OT - nutrition OT - overactive bladder OT - urinary incontinence COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/07/20 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193127 [pii] AID - nutrients-18-03127 [pii] AID - 10.3390/nu18193127 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3127. doi: 10.3390/nu18193127. PMID- 42884515 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 19 DP - 2026 Oct 6 TI - Gamified IMU Sensor-Based System for Training Head-Orientation Tasks in Healthy Teenagers: Event-Driven Architecture and Randomised Pilot Feasibility Study. LID - 10.3390/s26196315 [doi] LID - 6315 AB - Sensor systems integrated with gamified environments have increasingly been incorporated into the monitoring of musculoskeletal disorders. This study evaluates the operational feasibility of a motion-capture system based on an inertial measurement unit for training head-orientation tasks. Because a single sensor is placed on the head without thoracic fixation, the system estimates head orientation relative to space rather than isolated cervical motion. The event-driven architecture is organised into five logical layers and uses an asynchronous publish-subscribe bus for data acquisition, sensor fusion through the Madgwick filter, and local rendering in WebGL. A randomised pilot study involving 22 teenagers allocated to two parallel groups (11 per group) was conducted over eight weeks (three sessions per week). Participants were assigned to either the gamified system or a comparable active cervical exercise program. No participant-reported connectivity or hardware events prevented session completion. Self-reported adherence was 100%, and no adverse events were reported. Exploratory analyses showed that both groups reduced task completion time, whereas the reduction in time spent outside the target trajectory was statistically significant only in the experimental group; the between-group comparison of pre-post changes was not statistically significant. These findings indicate the system's operational feasibility in healthy teenagers. FAU - Calleja-Caballero, Andrea AU - Calleja-Caballero A AUID- ORCID: 0000-0002-4674-7025 AD - Department of Nursing and Physiotherapy, University of Salamanca, 37007 Salamanca, Spain. AD - Neurorehabilitation Research Group, Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain. FAU - Sanchez San-Blas, Hector AU - Sanchez San-Blas H AUID- ORCID: 0000-0003-1808-4364 AD - Ontology Engineering Group, ETSI Informaticos, Polytechnic University of Madrid, 28223 Madrid, Spain. FAU - Prieto Prieto, Josue AU - Prieto Prieto J AUID- ORCID: 0000-0002-6379-451X AD - Instituto Universitario de Ciencias de la Educacion (IUCE), University of Salamanca, 37008 Salamanca, Spain. FAU - Perez-Robledo, Fatima AU - Perez-Robledo F AUID- ORCID: 0000-0003-2695-0250 AD - Department of Nursing and Physiotherapy, University of Salamanca, 37007 Salamanca, Spain. AD - Neurorehabilitation Research Group, Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain. FAU - Mendes, Andre Filipe Sales AU - Mendes AFS AUID- ORCID: 0000-0003-0976-2784 AD - Department of Computer Science and Automation, University of Salamanca, 37008 Salamanca, Spain. AD - CREA-Salud Research Group, Salamanca Primary Care Management, Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain. LA - eng GR - PC_TCUE25_026/Universidad de Salamanca/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20261006 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Feasibility Studies MH - *Head/physiology MH - Head Movements/physiology MH - *Motion Capture/instrumentation MH - Pilot Projects MH - *Video Games PMC - PMC13667489 OTO - NOTNLM OT - BLE sensors OT - edge computing OT - event-driven architecture OT - gamification OT - head orientation OT - human-computer interaction COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/06 CRDT- 2026/10/16 01:09 PHST- 2026/09/04 00:00 [received] PHST- 2026/09/30 00:00 [revised] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:09 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - s26196315 [pii] AID - sensors-26-06315 [pii] AID - 10.3390/s26196315 [doi] PST - epublish SO - Sensors (Basel). 2026 Oct 6;26(19):6315. doi: 10.3390/s26196315. PMID- 42884202 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261022 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 19 DP - 2026 Sep 22 TI - Quantifying Physical Activity in Toddlers with Down Syndrome with Wearable Sensors During a Home-Based Mobility Intervention. LID - 10.3390/s26196002 [doi] LID - 6002 AB - BACKGROUND: Quantifying movement during early mobility interventions is important for evaluating intervention participation and progression in toddlers with Down syndrome (DS), but behavioral video coding is time and labor-intensive. This study established and evaluated an activity count cutpoint for distinguishing moderate-to-vigorous physical activity (MVPA) and sedentary-to-light physical activity (SLPA) in toddlers with DS during a home-based mobility intervention using a wearable accelerometer integrated into a body-weight support harness system. METHODS: Video recordings behaviorally coded for MVPA and SLPA were synchronized with accelerometer activity counts binned in 5 s epochs. Receiver operating characteristic curve analysis was used to determine both group-derived and participant-specific activity count cutpoints. RESULTS: The optimal group-derived cutpoint was 141 activity counts per 5 s, demonstrating strong classification performance (AUC = 0.903), with 94.4% sensitivity, 70.2% specificity, and an overall classification accuracy of 79.2%. Participant-specific cutpoints resulted in only minimal improvements in classification performance. CONCLUSIONS: These findings suggest that using individualized cutpoints may not be necessary for classifying MVPA in toddlers with DS during this intervention, though replication in a larger sample is warranted. A standardized activity count cutpoint may provide a practical approach for objectively monitoring activity during home-based mobility interventions. FAU - Athreya, Varsha AU - Athreya V AUID- ORCID: 0009-0007-9982-0824 AD - Department of Computer Engineering, Boston University, Boston, MA 02215, USA. FAU - Mishra, Simoni AU - Mishra S AUID- ORCID: 0009-0004-8389-8748 AD - Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. FAU - Collimore-Doherty, Ashley N AU - Collimore-Doherty AN AUID- ORCID: 0000-0001-6002-3667 AD - Department of Physical Therapy, Boston University, Boston, MA 02215, USA. FAU - Sutter, Ellen N AU - Sutter EN AUID- ORCID: 0000-0002-9883-8471 AD - Department of Physical Therapy, Boston University, Boston, MA 02215, USA. FAU - Iverson, Jana M AU - Iverson JM AUID- ORCID: 0000-0001-9160-7825 AD - Department of Physical Therapy, Boston University, Boston, MA 02215, USA. LA - eng GR - 1UL1TR001430/Clinical and Translational Science Institute/ GR - 1R21HD111945-01/NH/NIH HHS/United States GR - 1F32HD117600-01/NH/NIH HHS/United States GR - F32 HD117600/HD/NICHD NIH HHS/United States GR - R21 HD111945/HD/NICHD NIH HHS/United States GR - Boston University/ GR - UL1 TR001430/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260922 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Down Syndrome/physiopathology MH - *Wearable Electronic Devices MH - *Exercise/physiology MH - Child, Preschool MH - Accelerometry/methods/instrumentation MH - Female MH - Male MH - ROC Curve MH - Infant PMC - PMC13667628 OTO - NOTNLM OT - Down syndrome OT - accelerometer OT - intervention OT - physical activity OT - toddler OT - wearable sensor COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/22 CRDT- 2026/10/16 01:08 PHST- 2026/07/20 00:00 [received] PHST- 2026/09/04 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:08 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - s26196002 [pii] AID - sensors-26-06002 [pii] AID - 10.3390/s26196002 [doi] PST - epublish SO - Sensors (Basel). 2026 Sep 22;26(19):6002. doi: 10.3390/s26196002. PMID- 42883820 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 19 DP - 2026 Sep 25 TI - Maternal Gestational Hypertension Is Associated with Reduced TSG-6 in Human Milk: Potential Implications for Neonatal Immunological Support. LID - 10.3390/ijms27198573 [doi] LID - 8573 AB - Tumor necrosis factor alpha-stimulated protein 6 (TSG-6) is a potent anti-inflammatory mediator secreted by mesenchymal stem cells (MSCs). In human milk (HM), these cells (human milk mesenchymal stem cells, HM-MSCs) contribute to postnatal programming of the neonatal gastrointestinal immune axis. This study assessed how maternal gestational hypertension and maternal age affect the cytoprotective TSG-6 pool and its associated immunomodulatory microRNA signature in early milk. Early colostrum, 2-4 days postpartum, from healthy mothers and hypertensive patients was analyzed. TSG-6 gene expression in the heterogeneous milk cellular fraction containing HM-MSCs and TSG-6 protein concentration in whole milk were determined using quantitative polymerase chain reaction (qPCR) and Enzyme-Linked Immunosorbent Assay (ELISA), respectively. Comprehensive multivariable General Linear Models (GLMs) were used to adjust for potential confounding variables, including pre-pregnancy Body Mass Index (BMI), gestational age (GA), and gestational diabetes. Additionally, TSG-6 levels were correlated with fetal cord blood gas parameters and previously profiled microRNAs in the cellular fraction. GLM analysis revealed that gestational hypertension remained significantly associated with reduced TSG-6 gene expression in the cellular fraction and total TSG-6 protein concentration in whole milk, regardless of pre-pregnancy BMI or metabolic comorbidities. In healthy pregnancies, exploratory analyses suggested that TSG-6 levels correlated positively with optimal fetal metabolic status (cord blood pH). Importantly, TSG-6 expression showed a strong positive correlation with a signature of immunomodulatory microRNAs (miR) (miR-155-5p, miR-21-3p, miR-126-3p). These microRNAs were concurrently downregulated in the hypertensive group; however, because all hypertensive participants received methyldopa, the independent contributions of hypertension and antihypertensive treatment to these changes cannot be distinguished. Gestational hypertension independently reduces the anti-inflammatory TSG-6 in early breast milk. The concomitant reduction in TSG-6 and its correlated microRNA co-expression pattern indicates an altered immunomodulatory profile within the mammary gland during lactation. We hypothesize that these changes might alter the local immunomodulatory properties of milk in the neonatal gastrointestinal tract. However, because no functional in vitro or in vivo assays were performed, this remains a purely theoretical implication that requires future experimental validation. FAU - Przywara, Dominika AU - Przywara D AUID- ORCID: 0000-0002-6143-9653 AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. AD - Doctoral School, Medical University of Lublin, 20-093 Lublin, Poland. FAU - Kondracka, Adrianna AU - Kondracka A AD - Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland. FAU - Petniak, Alicja AU - Petniak A AUID- ORCID: 0000-0001-9926-0870 AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. FAU - Slyk-Gulewska, Patrycja AU - Slyk-Gulewska P AUID- ORCID: 0009-0008-6201-6514 AD - Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland. FAU - Drag, Magdalena AU - Drag M AUID- ORCID: 0000-0002-9351-8997 AD - Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland. FAU - Szymanowska, Urszula AU - Szymanowska U AUID- ORCID: 0000-0001-9692-2111 AD - Department of Biochemistry and Food Chemistry, University of Life Sciences, 8 Skromna Str., 20-704 Lublin, Poland. FAU - Czuba, Monika AU - Czuba M AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. FAU - Jaremek, Milena AU - Jaremek M AUID- ORCID: 0000-0002-9504-2216 AD - Department of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin, 54 Doswiadczalna Street, 20-280 Lublin, Poland. FAU - Strachecka, Aneta AU - Strachecka A AD - Department of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin, 54 Doswiadczalna Street, 20-280 Lublin, Poland. FAU - Kocki, Janusz AU - Kocki J AUID- ORCID: 0000-0002-9541-6353 AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. FAU - Gil-Kulik, Paulina AU - Gil-Kulik P AUID- ORCID: 0000-0003-3119-981X AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. LA - eng GR - Grant nr: INT/006/2025/IV-N)./Union of Lublin Universities/ PT - Journal Article DEP - 20260925 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (TNFAIP6 protein, human) RN - 0 (Cell Adhesion Molecules) RN - 0 (MicroRNAs) SB - IM MH - Humans MH - Female MH - *Cell Adhesion Molecules/metabolism/genetics MH - Pregnancy MH - *Hypertension, Pregnancy-Induced/metabolism/immunology/genetics MH - *Milk, Human/metabolism/immunology MH - MicroRNAs/genetics/metabolism MH - Adult MH - Infant, Newborn MH - Mesenchymal Stem Cells/metabolism PMC - PMC13665462 OTO - NOTNLM OT - HM-MSCs OT - TSG-6 OT - fetal metabolic status OT - gestational hypertension OT - human milk mesenchymal stem cells OT - microRNA COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/25 CRDT- 2026/10/16 01:07 PHST- 2026/08/27 00:00 [received] PHST- 2026/09/20 00:00 [revised] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:07 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - ijms27198573 [pii] AID - ijms-27-08573 [pii] AID - 10.3390/ijms27198573 [doi] PST - epublish SO - Int J Mol Sci. 2026 Sep 25;27(19):8573. doi: 10.3390/ijms27198573. PMID- 42882043 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 19 DP - 2026 Sep 29 TI - Continuous Glucose Monitoring for Women with Gestational Diabetes, CORDELIA: A Multicentric Randomized Controlled Trial, Methodology and Design. LID - 10.3390/jcm15197581 [doi] LID - 7581 AB - Background/Objectives: Gestational diabetes mellitus (GDM) is associated with increased short- and long-term risks for both mother and child. Screening and treatment between 24 and 30 weeks' gestation reduces adverse pregnancy outcomes, while emerging evidence suggests that earlier diagnosis and treatment (<20 weeks') in high-risk populations may further improve neonatal outcomes. Currently, self-monitoring of blood glucose (SMBG) remains the standard of care for management but provides only intermittent glycemic data and limited insight into overall glucose patterns. Real-time continuous glucose monitoring (rt-CGM) has transformed management in pregnancies complicated by type 1 diabetes but has shown conflicting results in GDM; it is thus unclear whether similar benefits may extend to women with GDM, including women with early GDM. Methods: The Continuous Glucose Monitoring for Women With Gestational Diabetes (CORDELIA) study is an ongoing, large, open-label, multicenter randomized controlled trial conducted across 14 centers in Belgium and two centers in Australia. Women diagnosed with GDM are randomized in a 1:1 ratio to either rt-CGM (intervention group) or standard care with SMBG (control group). Both women with early GDM diagnosed before 20 weeks' gestation and those diagnosed between 24.0 and 29.6 weeks' gestation are included. Participants attend the following visits: baseline visit at GDM diagnosis, an additional visit at 20.0-23.9 weeks' (if early GDM), 31.0-33.6 weeks' and 36.0-38.6 weeks', and a postpartum oral glucose tolerance test (OGTT) assessment (6.0-23.6 weeks after delivery). At each visit, clinical assessment, HbA1c, and (blinded) CGM are evaluated, alongside validated patient-reported outcome questionnaires. The primary objective is to compare the incidence of a composite of adverse pregnancy outcomes between the rt-CGM and SMBG groups. The primary outcome is a composite of adverse pregnancy outcomes including preterm delivery <37 weeks, LGA [customized percentiles according to Gestation Related Optimal Weight chart (GROW)], neonatal hypoglycemia requiring intravenous dextrose, neonatal intensive care unit (NICU) admission > 24 h, neonatal respiratory distress, stillbirth or neonatal death, phototherapy, birth trauma, and shoulder dystocia. Secondary outcomes include maternal glycemia, insulin use, pregnancy and neonatal outcomes, glycemic variability, patient-reported outcomes, and prespecified secondary analyses according to timing of GDM diagnosis and maternal BMI. Trial Registration: ClinicalTrials.gov: NCT06310356. First posted: 15 March 2024. FAU - Geerts, Ina AU - Geerts I AUID- ORCID: 0009-0004-2803-7013 AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. FAU - Yu, Catherine AU - Yu C AUID- ORCID: 0009-0005-7013-8640 AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. FAU - Bochanen, Niels AU - Bochanen N AUID- ORCID: 0000-0002-1265-9086 AD - Department of Endocrinology-Diabetology-Metabolism, Antwerp University Hospital, 2650 Edegem, Belgium. FAU - Heyns, Ellen AU - Heyns E AD - Department of Endocrinology, General Hospital Groeninge Kortrijk, 8500 Kortrijk, Belgium. FAU - Pottelbergh, Inge Van AU - Pottelbergh IV AD - Department of Endocrinology, AZORG Aalst, 9300 Aalst, Belgium. FAU - Morrens, Astrid AU - Morrens A AD - Department of Endocrinology, ZAS Palfijn, 2170 Merksem, Belgium. FAU - Coremans, Peter AU - Coremans P AD - Department of Endocrinology-Diabetology, Vitaz, 9100 Sint-Niklaas, Belgium. FAU - Philips, Jean-Christophe AU - Philips JC AD - Department of Diabetology, Nutrition and Metabolic Diseases, CHU de Liege, 4000 Liege, Belgium. FAU - Carton, Tiphaine AU - Carton T AD - Department of Endocrinology, Erasme Hospital, 1070 Brussels, Belgium. FAU - Vandewalle, Sara AU - Vandewalle S AUID- ORCID: 0000-0001-8422-4973 AD - Department of Endocrinology-Diabetology, AZ Sint-Jan Brugge, 8000 Brugge, Belgium. FAU - Marlier, Joke AU - Marlier J AUID- ORCID: 0000-0002-9500-608X AD - Department of Endocrinology, UZ Gent, 9000 Gent, Belgium. FAU - Van Boxelaer, Inge AU - Van Boxelaer I AUID- ORCID: 0009-0000-0009-9598 AD - Department of Endocrinology, AZ Sint Lucas Gent, 9000 Gent, Belgium. FAU - Winne, Linsey AU - Winne L AD - Department of Endocrinology, AZ Oostende, 8400 Oostende, Belgium. FAU - Bollaerts, Kathleen AU - Bollaerts K AD - Department of Endocrinology, AZ Sint Maarten Mechelen, 2800 Mechelen, Belgium. FAU - Lee, Dahae AU - Lee D AD - Department of Endocrinology, Imelda Bonheiden, 2820 Bonheiden, Belgium. FAU - Simmons, David AU - Simmons D AUID- ORCID: 0000-0003-0560-0761 AD - School of Medicine, Western Sydney University, Sydney, NSW 2560, Australia. FAU - Sweeting, Arianne AU - Sweeting A AUID- ORCID: 0000-0001-6843-6247 AD - Department of Endocrinology, Royal Prince Alfred Hospital and Charles Perkins Centre, University of Sydney, Sydney, NSW 2050, Australia. FAU - Laenen, Annouschka AU - Laenen A AUID- ORCID: 0000-0002-1371-442X AD - Leuven Biostatistics and Statistical Bioinformatics Centre, KU Leuven, 3000 Leuven, Belgium. FAU - Mathieu, Chantal AU - Mathieu C AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. AD - Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium. FAU - Benhalima, Katrien AU - Benhalima K AUID- ORCID: 0000-0002-3325-0263 AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. AD - Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium. LA - eng SI - ClinicalTrials.gov/NCT06310356 GR - Abbott Diabetes Care/ GR - LifeScan/ GR - Research Foundation - Flanders/ PT - Journal Article DEP - 20260929 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13665732 OTO - NOTNLM OT - continuous glucose monitoring OT - early gestational diabetes OT - gestational diabetes mellitus OT - pregnancy outcomes COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/29 CRDT- 2026/10/16 01:01 PHST- 2026/07/10 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/25 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - jcm15197581 [pii] AID - jcm-15-07581 [pii] AID - 10.3390/jcm15197581 [doi] PST - epublish SO - J Clin Med. 2026 Sep 29;15(19):7581. doi: 10.3390/jcm15197581. PMID- 42881975 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 19 DP - 2026 Sep 27 TI - In the Age of Artificial Intelligence: From Standardized Questions to Real-World Breastfeeding Concerns. LID - 10.3390/jcm15197513 [doi] LID - 7513 AB - Background: Breastfeeding is the recommended source of infant nutrition, yet mothers may experience concerns and difficulties that require timely access to reliable information and professional support. As the use of digital health tools increases, AI-powered chatbots such as ChatGPT and Gemini are increasingly accessible sources of breastfeeding information and support. This study aimed to descriptively compare responses generated by ChatGPT and Gemini with established breastfeeding information and multidisciplinary clinical support provided in real-world practice, using both standardized breastfeeding questions and clinic-derived scenarios. Materials and Methods: A descriptive comparative content-analysis study was conducted at Aretaieio University Hospital. Ten breastfeeding-related questions were included: five standardized questions derived from educational materials of the Institute of Child Health in Greece and five clinic-derived scenarios originating from individualized consultations through the hospital's breastfeeding-support helpline. Identical prompts were submitted independently to ChatGPT and Gemini as single-turn interactions without supplementary information or follow-up. AI-generated responses to the five standardized questions were descriptively compared with the corresponding information provided by the Institute of Child Health, whereas responses to five clinic-derived scenarios were compared with the clinical guidance and management provided in real-world practice. Results: Both AI platforms provided relevant, detailed, and supportive responses, particularly to standardized questions. However, the clinic-derived scenarios highlighted dimensions of individualized lactation care that extended beyond the AI-generated responses, particularly direct clinical assessment, access to relevant clinical history, interpretation of emotional and contextual cues, continuity of care, and coordination of multidisciplinary care and practical support. Conclusions: As AI becomes increasingly integrated into everyday health information-seeking, its role in breastfeeding support needs to be clearly defined. AI platforms may complement professional care by providing accessible preliminary information and support, while individualized breastfeeding care remains rooted in direct assessment, continuity of professional care, and trusted human relationships. FAU - Kkirgia, Maria AU - Kkirgia M AUID- ORCID: 0000-0003-2443-8042 AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. FAU - Magklara, Elli-Panagiota AU - Magklara EP AUID- ORCID: 0000-0002-6556-2173 AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. FAU - Zoupa, Christiana AU - Zoupa C AUID- ORCID: 0009-0007-6358-994X AD - Artificial Intelligence for Business, Bologna Business School, 40136 Bologna, Italy. FAU - Volaki, Paraskevi AU - Volaki P AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. FAU - Mougiou, Vasiliki AU - Mougiou V AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. FAU - Iliodromiti, Zoi AU - Iliodromiti Z AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. FAU - Boutsikou, Theodora AU - Boutsikou T AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. FAU - Iacovidou, Nicoletta AU - Iacovidou N AUID- ORCID: 0000-0001-8021-6191 AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. FAU - Sokou, Rozeta AU - Sokou R AUID- ORCID: 0000-0002-9972-8901 AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. LA - eng PT - Journal Article DEP - 20260927 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13665832 OTO - NOTNLM OT - Artificial Intelligence OT - breastfeeding OT - lactation support OT - large language models OT - neonatal support OT - postpartum care COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/27 CRDT- 2026/10/16 01:01 PHST- 2026/09/08 00:00 [received] PHST- 2026/09/23 00:00 [revised] PHST- 2026/09/25 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/09/27 00:00 [pmc-release] AID - jcm15197513 [pii] AID - jcm-15-07513 [pii] AID - 10.3390/jcm15197513 [doi] PST - epublish SO - J Clin Med. 2026 Sep 27;15(19):7513. doi: 10.3390/jcm15197513. PMID- 42881790 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 8 TI - Complementary and Alternative Medicine Use Among Families of Children with Autism Spectrum Disorder Attending Five Autism Centres in Arab Countries: Associations with Sociodemographic Factors and Health Literacy. LID - 10.3390/healthcare14193351 [doi] LID - 3351 AB - Background: Complementary and alternative medicine (CAM) therapies are commonly used among children with autism spectrum disorder (ASD). This study aimed to examine parental attitudes toward CAM, in addition to patterns of its use and associated factors among children with ASD in Arab countries. Methods: In this cross-sectional survey, 142 questionnaires from five Arab countries (Qatar, the Kingdom of Saudi Arabia [KSA], Kuwait, Jordan, and Libya) were analysed. Results: The most reported CAM modalities included dietary supplements such as multivitamins and fish oil, as well as the questionnaire item labelled "holding therapy". The main reason for CAM use reported by parents was the desire to try all possible therapy options for their child and reduce stress (35.5%), followed by improving their child's quality of life (32.6%). The regression models showed that better verbal ability was associated with greater use of these therapies (use of short/complex sentences vs. does not talk: biologically based therapies, OR = 5.35, 95% CI 1.58-18.56; mind and body practices, OR = 4.30, 95% CI 1.66-11.23). The models also showed an association between the male sex and the use of mind and body practices (OR = 3.28, 95% CI 1.23-8.92). Conclusions: CAM use was common in this sample. Healthcare professionals should provide balanced, evidence-based information and encourage non-judgmental discussion of CAM use. Improving health literacy and access to reliable information may support safer decision-making. FAU - Hatahet, Mais AU - Hatahet M AD - Doctoral School of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary. FAU - Chau, Nguyen Minh AU - Chau NM AD - Department of Health Informatics, Institute of Health Sciences, Faculty of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary. FAU - Sarvary, Andrea AU - Sarvary A AD - Department of Psychology, Institute of Social Sciences, Faculty of Health Sciences, University of Debrecen, 4400 Nyiregyhaza, Hungary. FAU - Sarvary, Attila AU - Sarvary A AUID- ORCID: 0000-0002-5082-4441 AD - Department of Nursing and Integrative Health Sciences, Institute of Health Sciences, Faculty of Health Sciences, University of Debrecen, 4400 Nyiregyhaza, Hungary. LA - eng PT - Journal Article DEP - 20261008 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13664931 OTO - NOTNLM OT - autism spectrum disorder OT - children OT - complementary and alternative medicine OT - health literacy COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/08 CRDT- 2026/10/16 01:01 PHST- 2026/08/06 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - healthcare14193351 [pii] AID - healthcare-14-03351 [pii] AID - 10.3390/healthcare14193351 [doi] PST - epublish SO - Healthcare (Basel). 2026 Oct 8;14(19):3351. doi: 10.3390/healthcare14193351. PMID- 42881772 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 6 TI - Association of Halliwick-Based Aquatic Physical Activity with Health-Related Quality of Life in Children and Adolescents with Autism Spectrum Disorder: A Cross-Sectional Comparative Study. LID - 10.3390/healthcare14193323 [doi] LID - 3323 AB - BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, accompanied by restricted and repetitive patterns of behavior, interests, or activities. Given the considerable heterogeneity in symptom severity and functional abilities, children with ASD require individualized educational and therapeutic interventions. Among the non-pharmacological approaches used to support this population, aquatic physical activity has emerged as a promising intervention. MATERIAL AND METHODS: The study included 45 children with ASD (ICD-11 code 6A02), comprising 19 girls and 26 boys, aged 8-17 years. Two groups were compared: Group G1, consisting of children and adolescents who had participated in Halliwick-based aquatic physical activity for at least 3 months, and Group G2, without aquatic activities. Health-related quality of life was assessed using the validated Polish version of the KIDSCREEN-52 questionnaire. RESULTS: Children with ASD who participated in Halliwick-based aquatic physical activity (G1) had higher mean scores in all KIDSCREEN-52 domains. However, statistically significant differences were only found in the following domains: Psychological Well-Being, Moods and Emotions, Self-Perception, Autonomy, Financial Resources, and School Environment. Overall health-related quality of life, measured by the KIDSCREEN-10, compared with children who did not participate in aquatic activities. CONCLUSIONS: Halliwick-based aquatic physical activity was associated with better quality of life in children and adolescents with ASD, with higher scores observed according to sex, but further research is needed to confirm these findings. FAU - Stefanska, Malgorzata AU - Stefanska M AUID- ORCID: 0000-0003-2070-8535 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Science, al. Paderewskiego 35, 51-612 Wroclaw, Poland. FAU - Smetek, Wiktoria AU - Smetek W AD - Reh-Medica Marek Smiech, ul. Odrzanska 7, 47-224 Kedzierzyn-Kozle, Poland. FAU - Kowalska, Joanna AU - Kowalska J AUID- ORCID: 0000-0002-5232-1688 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Science, al. Paderewskiego 35, 51-612 Wroclaw, Poland. FAU - Ptak, Agnieszka AU - Ptak A AUID- ORCID: 0000-0002-8396-5267 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Science, al. Paderewskiego 35, 51-612 Wroclaw, Poland. LA - eng PT - Journal Article DEP - 20261006 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13665036 OTO - NOTNLM OT - Halliwick method OT - KIDSSCREEN OT - aquatic physical activity OT - autism spectrum disorders OT - physical activity OT - quality of life COIS- Author Wiktoria Smetek was employed by Reh-Medica Marek Smiech. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/10/06 CRDT- 2026/10/16 01:01 PHST- 2026/07/23 00:00 [received] PHST- 2026/09/12 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - healthcare14193323 [pii] AID - healthcare-14-03323 [pii] AID - 10.3390/healthcare14193323 [doi] PST - epublish SO - Healthcare (Basel). 2026 Oct 6;14(19):3323. doi: 10.3390/healthcare14193323. PMID- 42881744 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 3 TI - The Psychosocial Pathways of Expectancy-Value Beliefs, Physical Fitness, and Executive Function Among Adolescents. LID - 10.3390/healthcare14193305 [doi] LID - 3305 AB - Background/Objectives: Adequate physical fitness has been associated with cognitive health among adolescents, and psychosocial processes may help explain this relationship. However, evidence regarding the mechanisms linking physical fitness and cognitive health remains limited. Guided by expectancy-value theory, this study examined the direct and indirect effects of expectancy-value beliefs on executive function through physical fitness among adolescents. Methods: A prospective research design was used. Participants were 424 adolescents (58% female; Mage = 12.72 years, SD = 0.93) recruited from the southwestern United States. Physical fitness components, including cardiovascular fitness, muscular fitness, flexibility, and body mass index (BMI), were assessed using the FITNESSGRAM((R)) test battery. Expectancy-value beliefs and executive function were measured using validated self-report instruments. Structural equation modeling was conducted to examine the proposed relationships. Results: Expectancy-value beliefs were significantly associated with all physical fitness components (rs ranged from -0.86 to 0.46, ps < 0.01) except flexibility. Cardiovascular fitness and muscular fitness were negatively associated with executive function scores (rs ranged from -0.29 to -0.21, ps < 0.01), whereas BMI was positively associated with executive function scores. The proposed model demonstrated an acceptable fit (chi(2)/df = 284.16/113, p < 0.001; CFI = 0.90; RMSEA = 0.06, 90% CI [0.05, 0.07]). There was a significant indirect effect of expectancy-value beliefs on executive function through physical fitness (beta = -0.11). The model explained 12% of the variance in physical fitness and 9% of the variance in executive function. Conclusions: The findings provide evidence for the proposed psychosocial mediation model linking expectancy-value beliefs, physical fitness, and executive function among adolescents. It suggests strategies that strengthen perceived competence and task values may improve physical fitness and, in turn, enhance executive function. FAU - Shen, Dijun AU - Shen D AD - Department of Physical Education, Shanghai Lixin University Accounting and Finance, Shanghai 201620, China. FAU - Bao, Sarina AU - Bao S AD - Department of Earth and Planetary Science, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan. FAU - Zhang, Xiaoxia AU - Zhang X AUID- ORCID: 0000-0001-5076-9035 AD - School of Sport Sciences, West Virginia University, Morgantown, WV 26506-6116, USA. LA - eng PT - Journal Article DEP - 20261003 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13664947 OTO - NOTNLM OT - adolescents OT - cognitive health OT - executive function OT - expectancy-value beliefs OT - physical fitness OT - psychosocial mechanisms OT - structural equation modeling COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/10/03 CRDT- 2026/10/16 01:01 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/10/03 00:00 [pmc-release] AID - healthcare14193305 [pii] AID - healthcare-14-03305 [pii] AID - 10.3390/healthcare14193305 [doi] PST - epublish SO - Healthcare (Basel). 2026 Oct 3;14(19):3305. doi: 10.3390/healthcare14193305. PMID- 42881734 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 2 TI - Assessment of Methods to Estimate Resting and Total Energy Expenditure in Children and Adolescents with Cerebral Palsy: A Scoping Review. LID - 10.3390/healthcare14193295 [doi] LID - 3295 AB - Background/Objectives: Accurate assessment of resting energy expenditure (REE) and total energy expenditure (TEE) in children with cerebral palsy (CP) remains challenging. This review aimed to map and synthesize the existing evidence on methods used to estimate REE and TEE in children and adolescents with CP and identify their limitations and research gaps. Methods: A structured search was conducted in PubMed, Scopus, SciELO, EBSCO, and Embase for English or Spanish language articles published with no restrictions on publication date until September 2026. Studies that included children or adolescents from 0 to 19 years with a confirmed diagnosis of CP and that reported measured or estimated REE, basal metabolic rate (BMR), or TEE were included. Results: Nineteen studies met the inclusion criteria. Indirect calorimetry (IC) was the most frequently used method for measuring REE (n = 11, 57.9%), whereas doubly labeled water (DLW) was the reference method for TEE (n = 6, 31.6%). Standard predictive equations developed for TDC were used in three studies (15.8%) and frequently overestimated REE. In contrast, CP-specific predictive equations were less used and showed better estimations against reference methods. BIA-derived estimates, anthropometric approaches, and biomarker-based models remain insufficiently validated. Conclusions: IC remains the reference method for individualized assessment of REE, whereas DLW is the reference method for measuring TEE. Predictive equations for TDC are not recommended for children with CP. Further validation studies comparing BIA-derived estimates and CP-specific equations against reference methods are needed, particularly across Gross Motor Function Classification System (GMFCS) levels, nutritional status, and feeding method. FAU - Garcia-Iniguez, Jorge Abraham AU - Garcia-Iniguez JA AD - Instituto de Nutricion Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico. AD - Escuela de Nutricion, Universidad Autonoma de Guadalajara, Zapopan 45129, Jalisco, Mexico. FAU - Garcia-Contreras, Andrea Anais AU - Garcia-Contreras AA AUID- ORCID: 0000-0001-8750-6458 AD - Instituto de Nutricion Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico. LA - eng PT - Journal Article PT - Review DEP - 20261002 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13665139 OTO - NOTNLM OT - basal metabolic rate OT - cerebral palsy OT - children OT - doubly labeled water OT - energy expenditure OT - indirect calorimetry OT - resting energy expenditure OT - total energy expenditure COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/10/02 CRDT- 2026/10/16 01:01 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/10/02 00:00 [pmc-release] AID - healthcare14193295 [pii] AID - healthcare-14-03295 [pii] AID - 10.3390/healthcare14193295 [doi] PST - epublish SO - Healthcare (Basel). 2026 Oct 2;14(19):3295. doi: 10.3390/healthcare14193295. PMID- 42881684 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 1 TI - Self-Reported Training Needs and Continuing-Education Preferences of the School Medicine Workforce in Romania: A National Cross-Sectional Survey. LID - 10.3390/healthcare14193245 [doi] LID - 3245 AB - BACKGROUND/OBJECTIVES: The continuing professional development (CPD) needs of school medical personnel in Romania have not been characterised at a national scale. We quantified the workforce's self-reported training needs to inform a national CPD programme. METHODS: We conducted a cross-sectional, self-administered online survey (July-September 2025) of school physicians, nurses, dental physicians, and dental nurses, recruited by open invitation through the national school-medicine association's channels. Training needs (59 role-specific items in seven thematic domains) were rated on a 5-point Likert scale; internal consistency, cross-role contrasts, and regression predictors of the overall training-need score were assessed. RESULTS: The sample comprised 683 respondents (97.4% female; all eight development regions). Interest in further training was near-universal (99.0%); respondents preferred blended delivery (50.2%) and practical simulations (63.4%), with time (39.8%) and cost (37.5%) the leading barriers. Among generalist physicians and nurses, the highest-rated needs were emotional and school-adjustment disorders (59% high or very high need), major emergency first aid (58%), and principles of healthy nutrition (56%); across all roles, communicating with parents ranked highest (53%). Training needs differed by profession for digital skills, ethics, and social and child rights and between generalist professions for the clinical and health-education domains (p 30 mm managed at a tertiary pediatric surgery center between January 2023 and January 2026. Clinical presentation, US characteristics, management, and outcomes were evaluated. Height and weight measurements were retrospectively retrieved when available, and body mass index (BMI) was calculated and analyzed as a continuous variable. Multivariable logistic regression was used to identify factors independently associated with surgical intervention and ovarian torsion. Receiver operating characteristic (ROC) analysis was used to determine the optimal lesion diameter threshold for surgical intervention. A exploratory three-level clinical risk stratification framework was subsequently developed using the ROC-derived 60-mm lesion diameter threshold and the presence of abdominal/pelvic pain. RESULTS: Among 112 patients, 26 (23.2%) underwent surgical intervention, whereas 86 (76.8%) were managed conservatively. Surgical indications included ovarian torsion, complex adnexal masses, and persistent or enlarging cysts. Maximum lesion diameter was the strongest independent predictor of both surgical intervention and ovarian torsion. BMI was available for 95 patients (84.8%) and was not independently associated with surgical intervention or significantly different according to ovarian torsion status. The 60-mm threshold provided the best discrimination for surgical intervention. Surgical intervention occurred in 5/75 (6.7%), 2/8 (25.0%), and 19/29 (65.5%) patients in the low-, intermediate-, and high-risk groups, respectively (Fisher-Freeman-Halton exact test, p < 0.001). Ovarian torsion occurred in 2/75 (2.7%), 0/8 (0%), and 11/29 (37.9%) patients, respectively (Fisher-Freeman-Halton exact test, p < 0.001). CONCLUSIONS: Maximum lesion diameter was the strongest independent predictor of surgical intervention and ovarian torsion. BMI was not significantly associated with either outcome in the available anthropometric data. The new exploratory risk stratification framework showed distinct clinical patterns across risk categories but requires prospective external validation before clinical use. CI - (c) 2026 Japan Society of Obstetrics and Gynecology. FAU - Oztas, Tulin AU - Oztas T AUID- ORCID: 0000-0002-1010-3324 AD - Department of Pediatric Surgery, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye. FAU - Asir, Aysegul AU - Asir A AD - Department of Pediatrics, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye. LA - eng PT - Journal Article PL - Australia TA - J Obstet Gynaecol Res JT - The journal of obstetrics and gynaecology research JID - 9612761 SB - IM MH - Humans MH - Female MH - *Ovarian Torsion/surgery/diagnostic imaging/epidemiology MH - Adolescent MH - Retrospective Studies MH - *Ovarian Cysts/surgery/diagnostic imaging/complications/pathology MH - Ultrasonography OTO - NOTNLM OT - adolescent OT - ovarian cysts OT - ovarian torsion OT - risk factors OT - surgical procedures EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 CRDT- 2026/10/15 23:58 PHST- 2026/09/07 00:00 [revised] PHST- 2026/07/26 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/15 23:58 [entrez] AID - e70504 [pii] AID - 10.1111/jog.70504 [doi] PST - ppublish SO - J Obstet Gynaecol Res. 2026 Oct;52(10):e70504. doi: 10.1111/jog.70504. PMID- 42880881 OWN - NLM STAT- Publisher LR - 20261015 IS - 2380-9426 (Electronic) IS - 2380-9418 (Linking) DP - 2026 Oct 15 TI - Advancing Global Health Initiative Through Pediatric Vitamin A Supplementation. LID - JDNP-2025-0082.R1 [pii] LID - 10.1891/JDNP-2025-0082 [doi] AB - Background: Malnutrition, particularly vitamin A deficiency, affects approximately 49% of children aged 6-59 months in sub-Saharan Africa, increasing the risks of morbidity, mortality, poor growth, and preventable blindness. Tanzania has followed the World Health Organization's (WHO) guidelines for biannual vitamin A supplementation (VAS) since 2004, but rural access remains limited. A preliminary assessment at a rural Tanzanian day care showed only 29% VAS coverage, indicating a substantial gap in coverage. Objective: To improve nutritional health among children aged 6-59 months through a comprehensive VAS program at a local day care in Tanzania. Methods: An interdisciplinary team coordinated structural and workflow changes, secured the supplement through established partnerships, and administered it to all 21 eligible children per WHO protocols. Results: All 21 eligible children enrolled in the day care received their initial dose of VAS at implementation. VAS was sustained at 100% among 29 children, including the 21 original children and 8 newly enrolled. Conclusions: A structured, community-based supplementation program in rural Tanzania successfully addressed critical gaps in vitamin A access for children aged 6-59 months. Implications for Nursing: This quality improvement project demonstrates the feasibility of global health collaboration through strategic planning, stakeholder engagement, and context sensitivity to improve child health outcomes. CI - (c) 2026 Springer Publishing Company. FAU - Watt, Tenica K AU - Watt TK AD - School of Nursing, University of Maryland, Baltimore, MD, USA twatt001@umaryland.edu. FAU - Alessandrini, Erica A AU - Alessandrini EA AD - School of Nursing, University of Maryland, Baltimore, MD, USA. FAU - Fitzpatrick, Suzanna AU - Fitzpatrick S AD - School of Nursing, University of Maryland, Baltimore, MD, USA. FAU - Franquiz, Renee AU - Franquiz R AD - School of Nursing, University of Maryland, Baltimore, MD, USA. FAU - Jones-Swing, Taylor AU - Jones-Swing T AD - School of Nursing, University of Maryland, Baltimore, MD, USA. FAU - Snyder, B Elias AU - Snyder BE AD - River Rock Global Collective, Baltimore, MD, USA. LA - eng PT - Journal Article DEP - 20261015 PL - United States TA - J Dr Nurs Pract JT - Journal of doctoral nursing practice JID - 101685366 SB - IM OTO - NOTNLM OT - Africa OT - child mortality OT - morbidity OT - vitamin A supplement EDAT- 2026/10/15 23:31 MHDA- 2026/10/15 23:31 CRDT- 2026/10/15 21:04 PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:31 [pubmed] PHST- 2026/10/15 21:04 [entrez] AID - JDNP-2025-0082 [pii] AID - 10.1891/JDNP-2025-0082 [doi] PST - aheadofprint SO - J Dr Nurs Pract. 2026 Oct 15:JDNP-2025-0082.R1. doi: 10.1891/JDNP-2025-0082. PMID- 42880628 OWN - NLM STAT- Publisher LR - 20261015 IS - 1534-4436 (Electronic) IS - 1081-1206 (Linking) DP - 2026 Oct 15 TI - Pediatric Alpha-Gal Syndrome: From Missed Diagnosis to the Burden of Avoidance. LID - S1081-1206(26)01272-X [pii] LID - 10.1016/j.anai.2026.10.012 [doi] AB - BACKGROUND: Pediatric alpha-gal syndrome remains underrecognized because delayed reactions disconnect symptoms from mammalian exposure and gastrointestinal-only presentations may bypass allergy evaluation. Overly broad avoidance may subsequently impose nutritional and psychosocial burden during growth. OBJECTIVE: To synthesize pediatric evidence and provide a directed management framework emphasizing diagnostic delay, least-restrictive avoidance, nutritional burden, natural history, and reassessment. DATA SOURCES: A literature search was conducted using PubMed/MEDLINE for articles published through August 2026. STUDY SELECTIONS: Pediatric and age-stratified primary studies were prioritized. Adult and mixed-age studies informed areas with limited pediatric evidence, with consideration of their applicability to children. METHODS: Evidence was qualitatively synthesized by source; no risk-of-bias assessment was performed. RESULTS: Pediatric cohorts document prolonged diagnostic delay and frequent gastrointestinal-predominant presentations. Tick exposure is a key etiologic and diagnostic clue, but lack of a recalled bite does not exclude alpha-gal syndrome. Diagnosis requires a compatible delayed phenotype plus detectable alpha-gal-specific IgE; sensitization alone does not establish alpha-gal syndrome. Mammalian meat and internal organ meat are the core exclusions, whereas tolerated dairy should be preserved and additional restrictions individualized. Potential mammalian origin of a medication or vaccine warrants product-specific assessment rather than blanket avoidance. No prospective pediatric study has quantified dietary intake, nutrient status, growth, bone health, or quality of life. A 2026 meta-analysis of 1,162 predominantly adult or mixed-age patients found symptomatic improvement in 86.5% but complete resolution in 42.7%; no pediatric remission rate or validated challenge/reintroduction protocol exists. CONCLUSION: Care should combine cross-specialty evaluation, phenotype-directed testing, least-restrictive avoidance, nutritional surveillance, tick-bite prevention, emergency preparedness, and planned reassessment toward the broadest safely tolerated diet. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Miliordos, Konstantinos AU - Miliordos K AD - Pediatric Allergy Unit, Department of Pediatrics, General University Hospital of Patras, Patras, Greece. Electronic address: mhlcon95@gmail.com. FAU - Triga, Maria AU - Triga M AD - Pediatric Allergy Unit, Department of Pediatrics, General University Hospital of Patras, Patras, Greece. LA - eng PT - Journal Article PT - Review DEP - 20261015 PL - United States TA - Ann Allergy Asthma Immunol JT - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JID - 9503580 SB - IM OTO - NOTNLM OT - alpha-gal syndrome OT - children OT - delayed diagnosis OT - elimination diet OT - natural history OT - nutritional burden OT - oral food challenge OT - reintroduction EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:30 CRDT- 2026/10/15 20:31 PHST- 2026/09/04 00:00 [received] PHST- 2026/10/08 00:00 [revised] PHST- 2026/10/09 00:00 [accepted] PHST- 2026/10/15 23:30 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 20:31 [entrez] AID - S1081-1206(26)01272-X [pii] AID - 10.1016/j.anai.2026.10.012 [doi] PST - aheadofprint SO - Ann Allergy Asthma Immunol. 2026 Oct 15:S1081-1206(26)01272-X. doi: 10.1016/j.anai.2026.10.012. PMID- 42879776 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261020 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 15 TI - Socially Embedded Digital Coaching Platform to Promote Healthy Lifestyle and Mental Health in Underprivileged (Pre)Pregnant Couples and Young Families (Our Smart Family Buddy Program): Protocol for a Mixed Methods Study. PG - e88913 LID - 10.2196/88913 [doi] LID - e88913 AB - BACKGROUND: The early life course, that is, from preconception up until the first 1000 days of life, is pivotal for optimizing parental and child health. In deprived settings, unfavorable lifestyle behaviors and poor mental health are more prevalent, while access to effective, context-sensitive support is limited. Digital interventions combined with community-based approaches may help address these disparities. OBJECTIVE: This protocol describes the methodology and initial progress of the Our Smart Family Buddy (OSFB) program, which aims to develop, implement, and evaluate a socially embedded digital coaching platform to improve nutrition and mental well-being among (pre)pregnant couples and families in deprived neighborhoods. METHODS: The OSFB program is a multiphase mixed methods program conducted within a transdisciplinary consortium consisting of 6 interrelated work packages. The program is structured in 3 phases: phase 1, exploration and preparation; phase 2, cocreation, design, and development; and phase 3, prototype evaluation and optimization. Data collection includes quantitative questionnaires, qualitative interviews and focus groups, and digital user data from the platform. The primary outcomes include lifestyle behaviors (nutrition and sleep), mental well-being, user engagement, and implementation outcomes, including feasibility, acceptability, and reach. RESULTS: The program was funded in 2022. A transdisciplinary consortium was established in 2023. Data collection and analysis for phase 1 were conducted between 2023 and 2025, including literature reviews and exploratory interviews. A deprived neighborhood in the municipality of Rotterdam, the Netherlands, was selected as the target neighborhood. The target population was defined as (pre)pregnant couples and families with a child aged <4 years. Phase 2 is ongoing (2024-2026), focusing on iterative design through locally established field labs and community building. Phase 3 is planned for 2026 to 2028. CONCLUSIONS: This protocol describes a socially embedded, multiphase approach to developing and implementing a digital coaching intervention for families in vulnerable circumstances. Through a transdisciplinary approach within a real-world, local community setting, the OSFB program aims to develop a context-sensitive intervention to support sustainable behavior change in early life. CI - (c) Teuntje Wieles, Hilmar Bijma, Ageeth Rosman, Ineke Bolt, Marina Bos-de Vos, Isabelle Fabbricotti, Annelli Janssen, Koen Joosten, Evangelos Niforatos, Valentijn Visch, Regine Steegers-Theunissen. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Wieles, Teuntje AU - Wieles T AUID- ORCID: 0009-0005-4419-1421 AD - Department of Obstetrics & Gynecology, Erasmus MC, Dr Molewaterplein 40, Rotterdam, The Netherlands, 31 0107040704. FAU - Bijma, Hilmar AU - Bijma H AUID- ORCID: 0000-0002-5800-8051 AD - Department of Obstetrics & Gynecology, Erasmus MC, Dr Molewaterplein 40, Rotterdam, The Netherlands, 31 0107040704. AD - Department of Care Ethics, University of Humanistic Studies, Utrecht, The Netherlands. FAU - Rosman, Ageeth AU - Rosman A AUID- ORCID: 0000-0003-3751-2950 AD - Department of Obstetrics & Gynecology, Erasmus MC, Dr Molewaterplein 40, Rotterdam, The Netherlands, 31 0107040704. AD - Innovation Center of Care, Rotterdam University of Applied Sciences, Rotterdam, South Holland, The Netherlands. FAU - Bolt, Ineke AU - Bolt I AUID- ORCID: 0000-0002-9575-1354 AD - Section Medical Ethics, Philosophy and History of Medicine, Department of Public Health, Erasmus MC, Rotterdam, The Netherlands. FAU - Bos-de Vos, Marina AU - Bos-de Vos M AUID- ORCID: 0000-0001-7613-891X AD - Faculty of Industrial Design Engineering, Delft University of Technology, Delft, The Netherlands. FAU - Fabbricotti, Isabelle AU - Fabbricotti I AUID- ORCID: 0000-0003-2369-4781 AD - Department of Health Services Management and Organization, Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, The Netherlands. FAU - Janssen, Annelli AU - Janssen A AUID- ORCID: 0000-0003-0592-4803 AD - The Dutch Research Institute for Transitions (DRIFT), Erasmus University Rotterdam, Rotterdam, South Holland, The Netherlands. FAU - Joosten, Koen AU - Joosten K AUID- ORCID: 0000-0002-0504-2475 AD - Department of Neonatal and Pediatric Intensive Care, Erasmus MC, Rotterdam, The Netherlands. FAU - Niforatos, Evangelos AU - Niforatos E AUID- ORCID: 0000-0002-0484-4214 AD - Faculty of Industrial Design Engineering, Delft University of Technology, Delft, The Netherlands. FAU - Visch, Valentijn AU - Visch V AUID- ORCID: 0000-0001-5502-1691 AD - Faculty of Industrial Design Engineering, Delft University of Technology, Delft, The Netherlands. FAU - Steegers-Theunissen, Regine AU - Steegers-Theunissen R AUID- ORCID: 0000-0002-4353-5756 AD - Department of Obstetrics & Gynecology, Erasmus MC, Dr Molewaterplein 40, Rotterdam, The Netherlands, 31 0107040704. AD - Sophia's Children Hospital, Erasmus MC, Rotterdam, Netherlands. LA - eng PT - Journal Article DEP - 20261015 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Healthy Lifestyle MH - Female MH - *Mental Health MH - *Mentoring/methods/standards MH - Pregnancy MH - *Health Promotion/methods MH - Digital Health PMC - PMC13671683 OTO - NOTNLM OT - cocreation OT - deprived neighborhood OT - digital lifestyle platform OT - periconception health OT - vulnerable families COIS- Conflicts of Interest: The content of the programs Smarter Pregnancy App, Sneller Zwanger App and Slimmer Eten met je Kind are further developed to create the described prototype and minimum viable Family Buddy. RS-T is an initiator and creator of these programs and because of their affiliation, the Erasmus MC is owner of these programs. Dear Health, as part of Topicus, has a nonexclusive pilot license of www.slimmerzwanger.nl and www.smarterpregnancy.co.uk (May 2025-May 2027). EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 PMCR- 2026/10/15 CRDT- 2026/10/15 19:39 PHST- 2025/12/05 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 19:39 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - v15i1e88913 [pii] AID - 88913 [pii] AID - 10.2196/88913 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 15;15:e88913. doi: 10.2196/88913. PMID- 42879323 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261017 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 15 TI - Feasibility of High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumor and Young Adults With Isocitrate Dehydrogenase-Mutant Gliomas (HYPE): Protocol for a Randomized Controlled Trial. PG - e88718 LID - 10.2196/88718 [doi] LID - e88718 AB - BACKGROUND: Young adult survivors of pediatric brain tumors and young adult patients with isocitrate dehydrogenase (IDH) mutant gliomas are at risk for cognitive impairment, reduced physical fitness and function, as well as poor health-related quality of life (HRQOL) and psychosocial health. Exercise improves these outcomes; however, both populations remain understudied with respect to exercise interventions. High-intensity interval training (HIIT) is a promising intervention, as it is time-efficient, safe, tolerable, enhances cognition in healthy young adults, and improves physical fitness and quality of life in adult patients and survivors with cancer. However, the feasibility of HIIT is not yet understood in survivors of pediatric brain tumors and patients with IDH-mutant glioma. OBJECTIVE: The HYPE study is a pilot randomized controlled trial that aims to (1) determine the feasibility of a HIIT exercise intervention for young adult survivors of pediatric brain tumors and patients with IDH-mutant glioma, (2) determine the preliminary efficacy of HIIT to improve physical fitness and function, cognition, HRQOL, and psychosocial health, and (3) explore exercise sustainability and the impact of social determinants of health on study outcomes. METHODS: A total of 30 young adult survivors of pediatric brain tumors and patients with IDH-mutant glioma (18-45 years of age) will be randomized to an exercise or control group. The exercise group performs virtually supervised HIIT 3 times per week for 16 weeks, followed by 16 weeks of self-directed exercise. Exercise involves indoor cycling, and sessions include 20 minutes of high- and low-intensity intervals (high intensity=60-s 60%-90% peak power output; low intensity=60-s 10% peak power output), and a 5-minute warm-up and cool-down. The control group performs a 16-week stretching program. Feasibility of the HIIT intervention is measured by the number of exercise sessions completed, including total minutes and intensity, and barriers to exercise adherence. Cognition, physical fitness and function, HRQOL, and psychosocial health are measured using standardized assessments and self-report questionnaires. Exercise sustainability is measured by change in study outcomes following the self-directed follow-up period, and social determinants of health are assessed using a self-report questionnaire. RESULTS: Baseline data collection began in February 2024, and 13 participants have been enrolled as of June 2026. The projected study end date is December 2026. Data analysis is planned to begin in January 2027, and findings will be published in the fall of 2028. CONCLUSIONS: To our knowledge, this study is the first to use a virtually supervised HIIT intervention in young adult patients and survivors of brain tumor. The findings will elucidate the feasibility of HIIT to design and power a randomized controlled trial to address cancer- and treatment-related sequelae. They will also provide insights into the sustainability of HIIT and the impact of social determinants of health. CI - (c) Elizabeth Cox, Meghan Tahbaz, Ellaney Matarese, Rebekah L Wilson, L Nicolas Gonzalez Castro, Hajime Uno, Tabitha Cooney, Jordan Lane, Mary K Norris, Kira Bona, Rahela Aziz-Bose, Christina M Dieli-Conwright. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Cox, Elizabeth AU - Cox E AD - Department of Medicine, Harvard Medical School, Boston, MA, United States. FAU - Tahbaz, Meghan AU - Tahbaz M AD - Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States. FAU - Matarese, Ellaney AU - Matarese E AD - Department of Neuroscience, Harvard University, Cambridge, MA, United States. FAU - Wilson, Rebekah L AU - Wilson RL AUID- ORCID: 0000-0003-1704-3624 AD - Department of Medicine, Harvard Medical School, Boston, MA, United States. FAU - Gonzalez Castro, L Nicolas AU - Gonzalez Castro LN AUID- ORCID: 0000-0001-7699-5188 AD - Department of Neurology, Brigham and Women's Hospital/Mass General Brigham, Boston, MA, United States. AD - Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, United States. FAU - Uno, Hajime AU - Uno H AUID- ORCID: 0000-0003-0622-8471 AD - Department of Medicine, Harvard Medical School, Boston, MA, United States. FAU - Cooney, Tabitha AU - Cooney T AUID- ORCID: 0000-0002-2614-020X AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, United States. FAU - Lane, Jordan AU - Lane J AUID- ORCID: 0009-0005-3399-0957 FAU - Norris, Mary K AU - Norris MK AUID- ORCID: 0000-0002-8914-1306 FAU - Bona, Kira AU - Bona K AUID- ORCID: 0000-0001-5602-7059 AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, United States. AD - Department of Pediatrics, Harvard Medical School, Boston, MA, United States. FAU - Aziz-Bose, Rahela AU - Aziz-Bose R AUID- ORCID: 0000-0003-4753-5144 AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, United States. AD - Department of Pediatrics, Harvard Medical School, Boston, MA, United States. FAU - Dieli-Conwright, Christina M AU - Dieli-Conwright CM AUID- ORCID: 0000-0001-9093-7259 AD - Department of Medicine, Harvard Medical School, Boston, MA, United States. AD - Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, United States, 1 617-582-8321. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20261015 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 RN - EC 1.1.1.41 (Isocitrate Dehydrogenase) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Brain Neoplasms/genetics/therapy/psychology MH - Feasibility Studies MH - *Glioma/genetics/therapy/psychology MH - *High-Intensity Interval Training/methods/standards MH - *Isocitrate Dehydrogenase/genetics MH - Mutation MH - Pilot Projects MH - Quality of Life MH - Randomized Controlled Trials as Topic PMC - PMC13671388 OTO - NOTNLM OT - AYA OT - HIIT OT - IDH mutant glioma OT - cognitive function OT - exercise oncology OT - high-intensity interval training OT - isocitrate dehydrogenase-mutant glioma OT - pediatric brain tumors COIS- Conflicts of Interest: None declared. EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 PMCR- 2026/10/15 CRDT- 2026/10/15 19:01 PHST- 2025/12/01 00:00 [received] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 19:01 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - v15i1e88718 [pii] AID - 88718 [pii] AID - 10.2196/88718 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 15;15:e88718. doi: 10.2196/88718. PMID- 42879185 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1365-277X (Electronic) IS - 0952-3871 (Linking) VI - 39 IP - 5 DP - 2026 Oct TI - Feasibility and Accuracy of Caregiver-Led Child Growth Measurements for Remote Healthcare. PG - e70364 LID - 10.1111/jhn.70364 [doi] AB - BACKGROUND AND AIMS: Remote healthcare is expanding, with accurate growth data essential for nutritional care. Guidance for routine caregiver-led measurements is limited and largely untested. This study evaluated the feasibility and accuracy of caregiver-led child growth measurements at home, compared to 'gold-standard' measurements in the hospital. METHODS: Caregivers of children attending outpatient appointments completed a survey on their access to weighing scales and tape measures at home. Those with suitable equipment were consented to participate in a home measurement study. Using provided instructions, caregivers measured their child twice within 48 h of a hospital appointment, where two healthcare professionals (HCPs) repeated measurements. Caregiver experiences were explored through short interviews. Agreement between methods was assessed using Bland-Altman analysis. RESULTS: Of 677 survey respondents (49% response), 61% owned both scales and tape measure, with ownership more likely in relatively affluent postcodes. One hundred and forty participants consented to the home measurement study but due to low recruitment in the 0-2-age group (n = 18), analysis was restricted to 122 2-15-year-olds with median age 8.5 [IQR 5,12]. Participants were predominantly white British (88%) from relatively affluent areas (78% IMD 5-10). LOA between caregivers and HCP were -3.46% to 3.79% (height) and -4.91% to 4.36% (weight), demonstrating reasonable caregiver accuracy. LOA between the two caregiver measurements were -0.97% to 0.99% (weight) and -1.04% to 0.80% (height), demonstrating consistency, and LOA between two HCPs were -0.48% to 0.53% (weight) and -0.61% to 0.55% (height), demonstrating good inter-observer agreement. The majority found the process straightforward, with greater confidence in weighing than in measuring, despite achieving lower accuracy. Most were willing to routinely provide measurements before remote appointments. CONCLUSIONS: Caregiver-led measurements appear feasible and reasonably accurate for children aged 2-15 years, although they may be more suitable to monitor trends, rather than in situations needing precision. Equipment access may be limited in less affluent areas, but generally, caregivers are willing to monitor weight and height at home. CI - (c) 2026 British Dietetic Association. FAU - Trace, Sarah L AU - Trace SL AUID- ORCID: 0000-0003-4408-1255 AD - Department of Nutrition and Dietetics, Bristol Hospitals NHS Foundation Trust, Bristol, UK. FAU - Leary, Sam D AU - Leary SD AUID- ORCID: 0000-0002-1706-0689 AD - Bristol Dental School, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK. FAU - Richards, Kara Y AU - Richards KY AUID- ORCID: 0009-0000-5917-6578 AD - Department of Nutrition and Dietetics, Bristol Hospitals NHS Foundation Trust, Bristol, UK. FAU - Shield, Julian P H AU - Shield JPH AUID- ORCID: 0000-0003-2601-7575 AD - NIHR Bristol Biomedical Research Centre, Diet and Physical Activity Theme, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK. LA - eng GR - British Dietetic Association/ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - *Caregivers MH - Child MH - Child, Preschool MH - Adolescent MH - Female MH - Feasibility Studies MH - Male MH - Infant MH - *Child Development MH - Reproducibility of Results MH - Adult MH - Infant, Newborn OTO - NOTNLM OT - anthropometry OT - caregiver OT - child OT - growth OT - measurements OT - parent OT - remote EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 CRDT- 2026/10/15 18:43 PHST- 2026/09/23 00:00 [revised] PHST- 2026/06/08 00:00 [received] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 18:43 [entrez] AID - 10.1111/jhn.70364 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Oct;39(5):e70364. doi: 10.1111/jhn.70364. PMID- 42878977 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261019 IS - 1590-9999 (Electronic) IS - 1590-9921 (Print) IS - 1590-9921 (Linking) VI - 27 IP - 1 DP - 2026 Oct 15 TI - Clinical examination findings were not associated with isometric strength or functional performance in adults with groin pain. LID - 10.1186/s10195-026-00971-1 [doi] LID - 60 AB - OBJECTIVES: The aim of this study was to investigate whether positive clinical examination findings were associated with selected measures of lower-limb isometric strength or functional performance in physically active adults with groin pain. METHODS: This was a cross-sectional, observational and exploratory study with blinded outcome assessment. A total of 37 physically active adults (18-45 years) with clinically diagnosed groin pain (>/= 6 weeks) underwent standardised orthopaedic testing (flexion, abduction and external rotation [FABER]; flexion, adduction and internal rotation [FADIR]; scour; squeeze), targeted palpation (adductors, pubic symphysis), isometric hip and knee strength testing using a handheld dynamometer and functional performance tests (modified Star Excursion Balance Test [mSEBT], cross-over hop). Associations between clinical findings and strength/performance measures were analysed using adjusted binary logistic regression models controlling for age, body mass index and height, with false discovery rate correction. RESULTS: Participants demonstrated broadly similar right- and left-side performance in the mSEBT and cross-over hop tests, with strength ratios close to 1.0. Positive clinical examination findings were common, particularly for left adductor-region palpation (74.3% of valid observations) and the left FABER test (70.3%). After adjustment for multiple comparisons, no significant associations were found between positive clinical tests and functional or strength measures. CONCLUSIONS: In this exploratory sample of physically active adults with groin pain, positive orthopaedic and palpation tests were not significantly associated with deficits in dynamic balance or isometric strength. These findings are limited to the selected isometric and general functional measures and reinforce the importance of a multi-modal assessment that incorporates clinical classification, eccentric adductor strength testing and sport-specific functional evaluations to guide rehabilitation and return-to-sport decisions. CI - (c) 2026. The Author(s). FAU - Branco, Matheus Oliveira AU - Branco MO AD - Programa de Pos-Graduacao em Fisioterapia, Universidade do Estado de Santa Catarina, Florianopolis, SC, Brazil. AD - University Center Unifacvest, Lages, Santa Catarina, Brazil. FAU - Martins, Tamiris Beppler AU - Martins TB AD - Departamento de Fisioterapia, Centro de Ciencias, Tecnologias e Saude, Universidade Federal de Santa Catarina, Ararangua, SC, Brazil. FAU - da Costa, Guilherme Vinicius AU - da Costa GV AD - La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia. FAU - de Sousa, Vitor Mateus Madruga AU - de Sousa VMM AD - University Center Unifacvest, Lages, Santa Catarina, Brazil. FAU - Immich, Alan AU - Immich A AD - Programa de Pos-Graduacao em Fisioterapia, Universidade do Estado de Santa Catarina, Florianopolis, SC, Brazil. FAU - Dutra, Kaue Bertoto AU - Dutra KB AD - University of Planalto Catarinense, Lages, Santa Catarina, Brazil. FAU - Migliorini, Filippo AU - Migliorini F AUID- ORCID: 0000-0001-7220-1221 AD - Department of Trauma and Reconstructive Surgery, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Street 40, 06097, Halle, Saale, Germany. filippo.migliorini@uk-halle.de. AD - Department of Life Sciences, Health, and Health Professions, Link Campus University, Via del Casale di San Pio V, 00165, Rome, Italy. filippo.migliorini@uk-halle.de. AD - Research Department of Clinical Orthopaedics, Eifelklinik St. Brigida, Simmerath, Germany. filippo.migliorini@uk-halle.de. FAU - Maffulli, Nicola AU - Maffulli N AD - Department of Medicine, Surgery and Dentistry, University of Salerno, 84081, Baronissi, Italy. AD - School of Pharmacy and Bioengineering, Keele University Faculty of Medicine, Stoke on Trent, ST4 7QB, UK. AD - Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Mile End Hospital, Queen Mary University of London, London, E1 4DG, UK. FAU - Okubo, Rodrigo AU - Okubo R AD - Programa de Pos-Graduacao em Fisioterapia, Universidade do Estado de Santa Catarina, Florianopolis, SC, Brazil. LA - eng PT - Journal Article PT - Observational Study DEP - 20261015 PL - Italy TA - J Orthop Traumatol JT - Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology JID - 101090931 SB - IM MH - Humans MH - *Groin/physiopathology MH - Adult MH - Cross-Sectional Studies MH - Female MH - *Muscle Strength/physiology MH - Male MH - Middle Aged MH - *Physical Examination MH - *Isometric Contraction/physiology MH - *Physical Functional Performance MH - Young Adult MH - Adolescent MH - Pain Measurement PMC - PMC13672736 OTO - NOTNLM OT - Clinical examination OT - Dynamic balance OT - Functional performance OT - Groin pain OT - Hip muscle strength COIS- Declarations. Ethics approval and consent to participate: CAAE 42853720.0.0000.0118, 4.631.512. Patient involvement: Study participants were not involved in the design, conduct, interpretation or translation of the current research. Competing interests: The authors declare no conflicts of interest. EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 PMCR- 2026/10/15 CRDT- 2026/10/15 18:27 PHST- 2025/11/24 00:00 [received] PHST- 2026/10/04 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 18:27 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - 10.1186/s10195-026-00971-1 [pii] AID - 971 [pii] AID - 10.1186/s10195-026-00971-1 [doi] PST - epublish SO - J Orthop Traumatol. 2026 Oct 15;27(1):60. doi: 10.1186/s10195-026-00971-1. PMID- 42878537 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261027 IS - 1099-0496 (Electronic) IS - 1099-0496 (Linking) VI - 61 IP - 10 DP - 2026 Oct TI - Assessment of Cystic Fibrosis Lung Disease Using Electrical Impedance Tomography. PG - e71856 LID - e71856 [pii] LID - 10.1002/ppul.71856 [doi] AB - INTRODUCTION: Electrical impedance tomography (EIT) is a non-invasive, effort-independent imaging technique for measurement of regional lung ventilation and function that does not utilize ionizing radiation. There are limited data on the use of EIT to assess lung disease in people with CF (PwCF). METHODS: This was a cross-sectional observational cohort study. Study participants performed EIT, multiple breath washout (MBW) and spirometry in a single session. We analyzed EIT results to calculate the global inhomogeneity index (GII) and regional ventilation delay at 40% of maximal inspiratory impedance (RVD40). We used pairwise Spearman correlations to compare EIT measurements with the lung clearance index (LCI) and percent predicted forced expiratory volume in 1 s (FEV1pp). We generated receiver operator characteristic (ROC) curves to assess specificity and sensitivity for GII and RVD40 to predict an abnormal LCI. RESULTS: 31 participants ranging in age from 6 to 65 years performed EIT and spirometry; 23 performed research-quality MBW. The median GII and RVD40 were 39.1 and 5.52, respectively. The median LCI was 8.9. RVD40 correlated moderately with LCI (r = 0.49, p = 0.02) and negatively correlated with FEV1pp (r = -0.36, p = 0.04). There was a weak positive correlation between GII and LCI (r = 0.27, p = 0.21). GII demonstrated a significant negative correlation with FEV1pp (r = -0.44, p = 0.01). DISCUSSION: We found that EIT measurements correlated with spirometry and MBW. RVD40 was more sensitive and specific for ventilation inhomogeneity as compared to GII. Our data suggest that EIT measurements made during tidal breathing could be a useful clinical test in the evaluation of CF lung disease, though further investigations are needed. CI - (c) 2026 Wiley Periodicals LLC. FAU - Boas, Heather AU - Boas H AUID- ORCID: 0009-0003-1874-303X AD - Section of Pediatric Pulmonology, Dartmouth Health Children's, Lebanon, New Hampshire, USA. AD - Department of Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. FAU - Bennett, Laura AU - Bennett L AD - Biostatistics and Data Management Core, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Faerber, Jennifer AU - Faerber J AD - Biostatistics and Data Management Core, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Donnelly, Erin C AU - Donnelly EC AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Gari, Matthew AU - Gari M AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Sailman, Gina E AU - Sailman GE AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Pierdomenico, Alyssa AU - Pierdomenico A AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Napolitano, Natalie AU - Napolitano N AUID- ORCID: 0000-0002-1498-8465 AD - Respiratory Therapy Department, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Dorgan, Daniel AU - Dorgan D AD - Department of Pulmonary Medicine, Penn Medicine, Philadelphia, Pennsylvania, USA. AD - Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FAU - Panitch, Howard B AU - Panitch HB AUID- ORCID: 0000-0001-8440-283X AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FAU - Ren, Clement L AU - Ren CL AUID- ORCID: 0000-0003-4431-0644 AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. LA - eng GR - BOAS23D0/Cystic Fibrosis Foundation/ PT - Journal Article PT - Observational Study PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - *Cystic Fibrosis/physiopathology/diagnostic imaging MH - *Electric Impedance MH - Cross-Sectional Studies MH - Female MH - Male MH - Adolescent MH - Adult MH - *Tomography/methods MH - Middle Aged MH - Child MH - Spirometry MH - Young Adult MH - Aged MH - Respiratory Function Tests MH - Forced Expiratory Volume MH - ROC Curve MH - *Lung/physiopathology/diagnostic imaging MH - Sensitivity and Specificity OTO - NOTNLM OT - bioelectrical impedance OT - lung clearance index OT - lung imaging OT - pulmonary function test OT - ventilation inhomogeneity EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 CRDT- 2026/10/15 17:21 PHST- 2026/09/06 00:00 [revised] PHST- 2025/12/01 00:00 [received] PHST- 2026/09/26 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 17:21 [entrez] AID - e71856 [pii] AID - 10.1002/ppul.71856 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 Oct;61(10):e71856. doi: 10.1002/ppul.71856. PMID- 42877164 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261016 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Differential roles of confidence and competence in the association between understanding and enjoyment of physical activity: developmental and demographic moderators in children and adolescents. PG - 1875229 LID - 10.3389/fpubh.2026.1875229 [doi] LID - 1875229 AB - INTRODUCTION: Enjoyment is widely recognized as a key determinant of young people's engagement in physical activity (PA) and their longer-term active behaviors. However, less is known about the cognitive and affective mechanisms that underpin enjoyment, or how these vary across groups of pupils. This study examined the association between pupils' understanding of the benefits of PA, their confidence and perceived competence, and their enjoyment of PA, and explored whether these patterns differed according to gender, ethnicity, physical activity level, SEN status, or school setting. METHODS: A cross-sectional survey was completed by 637 pupils aged 8-16 years from five schools across England. Enjoyment, confidence, competence, and understanding of PA were each assessed using a single-item measure, administered alongside the Physical Activity Questionnaire for Children (PAQ-C). A path analysis model tested whether confidence and competence mediated the association between understanding and enjoyment, and multi-group structural equation modeling examined moderation; subgroup analyses were treated as exploratory. RESULTS: Understanding was indirectly associated with enjoyment through both confidence and competence, with confidence the stronger mediator across the full sample and for most subgroups; both indirect effects were statistically significant. Moderation analyses indicated that these patterns varied across physical activity level, school setting, and ethnicity, but not gender or SEN status. The relative contribution of confidence and competence shifted across school settings: confidence was the dominant mediator in secondary and special school settings, whereas in primary settings the two pathways did not differ reliably. Active pupils showed stronger confidence-mediated associations than less active peers. Apparent differences across ethnic groups were largely attributable to school composition. DISCUSSION: The study contributes to self-determination theory and physical literacy perspectives by showing how cognitive understanding is associated with the affective mechanisms linked to enjoyment, and how these associations vary across school settings. Practically, the findings suggest that PA provision may benefit from prioritizing confidence-building in secondary settings, competence-building in primary settings, and inclusive, culturally responsive pedagogies throughout; these implications follow from cross-sectional associations rather than demonstrated intervention effects. By centring enjoyment and its psychological antecedents, schools can support positive, sustainable relationships with physical activity that extend beyond the classroom. CI - Copyright (c) 2026 Vernon, Gregory, Bonner, Goldsmith and Turnbull. FAU - Vernon, Tim AU - Vernon T AD - School of Sport and Physical Activity, Sheffield Hallam University, Sheffield, United Kingdom. FAU - Gregory, Maxine AU - Gregory M AD - Mosodi Research, Manchester, United Kingdom. FAU - Bonner, Stuart AU - Bonner S AD - School of Sport and Physical Activity, Sheffield Hallam University, Sheffield, United Kingdom. FAU - Goldsmith, Simon AU - Goldsmith S AD - School of Sport and Physical Activity, Sheffield Hallam University, Sheffield, United Kingdom. FAU - Turnbull, Orla AU - Turnbull O AD - School of Sport and Physical Activity, Sheffield Hallam University, Sheffield, United Kingdom. LA - eng PT - Journal Article DEP - 20260930 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - *Exercise/psychology MH - England MH - Adolescent MH - Surveys and Questionnaires MH - *Self Concept MH - *Students/psychology/statistics & numerical data MH - Schools PMC - PMC13663660 OTO - NOTNLM OT - children and young people OT - confidence OT - enjoyment OT - mediation OT - physical activity OT - physical literacy OT - self-determination theory COIS- MG was employed by company Mosodi Research. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/15 17:38 MHDA- 2026/10/15 17:39 PMCR- 2026/09/30 CRDT- 2026/10/15 12:51 PHST- 2026/05/07 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/10/15 17:39 [medline] PHST- 2026/10/15 17:38 [pubmed] PHST- 2026/10/15 12:51 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1875229 [doi] PST - epublish SO - Front Public Health. 2026 Sep 30;14:1875229. doi: 10.3389/fpubh.2026.1875229. eCollection 2026. PMID- 42876603 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261015 LR - 20261016 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Socio-demographic and community-level determinants of delayed breastfeeding initiation in Borama, Somalia: a multilevel mixed-effects analysis. PG - 1945737 LID - 10.3389/fnut.2026.1945737 [doi] LID - 1945737 AB - BACKGROUND: Timely initiation of breastfeeding is a proven life-saving intervention for reducing neonatal morbidity and mortality. Despite global advocacy, adherence in fragile health systems remains critically low. This study assesses the magnitude and multi-level epidemiological predictors of delayed breastfeeding initiation among postnatal mothers in Borama, Somalia. METHODS: An institution-based cross-sectional study was conducted among 392 postnatal mothers (aged 15-49 years) recruited via systematic random sampling at the Sheekh Osman Center for Community Health. Data were gathered using a pre-tested, structured interviewer-administered questionnaire. Delayed breastfeeding initiation was defined as initiating suckling more than 30 min postpartum. Participants were nested within 14 recognized municipal neighborhood clusters in Borama. To account for community-level clustering, a four-step hierarchical multilevel mixed-effects logistic regression was performed. Fixed effects were expressed as Adjusted Odds Ratios (aOR) with 95% Confidence Intervals (CI), and random effects were quantified using the Intraclass Correlation Coefficient (ICC). RESULTS: The magnitude of delayed breastfeeding initiation was 40.8% (95% CI: 35.9-45.8%; n = 160 ). In bivariate analysis, delayed initiation was significantly associated with maternal education level ( p < 0.001 ) and absence of antenatal breastfeeding information ( p < 0.001 ). In the final fully adjusted multilevel model, the absence of breastfeeding counseling during antenatal care was the strongest independent predictor of delay (aOR = 7.93, 95% CI: 4.51-13.95, p < 0.001 ). Mothers without formal education had three-fold higher odds of delayed initiation compared to college-educated mothers (aOR = 3.07, 95% CI: 1.33-7.07, p = 0.008 ). Mothers aged 15-20 years had lower odds of delay compared to those older than 30 years (aOR = 0.39, 95% CI: 0.18-0.87, p = 0.021 ). The null model demonstrated significant community clustering (ICC = 18.1%, p < 0.001 ), which increased to 25.6% in the final adjusted model. CONCLUSION: Over four in ten mothers experienced delayed breastfeeding initiation. Gaps in antenatal counseling, lack of maternal formal education, and neighborhood-level clustering are primary drivers of delayed initiation. Health authorities must implement facility-based Baby-Friendly Hospital Initiative protocols and intensify antenatal lactation counseling. CI - Copyright (c) 2026 Hared, Omer Ali, Hassan, Ahmed, Abdi, Abdulahi and Nadarajah. FAU - Hared, Yusuf Abdi AU - Hared YA AD - Center for Community Services, Amoud University, Borama, Somalia. AD - School of Health and Welfare, Dalarna University, Falun, Sweden. FAU - Omer Ali, Abdirahman AU - Omer Ali A AD - Center for Community Services, Amoud University, Borama, Somalia. AD - College of Health Sciences, Amoud University, Borama, Somalia. FAU - Hassan, Abdisalam Mahdi AU - Hassan AM AD - Center for Community Services, Amoud University, Borama, Somalia. AD - College of Health Sciences, Amoud University, Borama, Somalia. FAU - Ahmed, Hodan Saed AU - Ahmed HS AD - Center for Community Services, Amoud University, Borama, Somalia. AD - College of Health Sciences, Amoud University, Borama, Somalia. FAU - Abdi, Muhiadin Ismail AU - Abdi MI AD - Center for Community Services, Amoud University, Borama, Somalia. AD - College of Health Sciences, Amoud University, Borama, Somalia. FAU - Abdulahi, Hodo Abdi AU - Abdulahi HA AD - Center for Community Services, Amoud University, Borama, Somalia. FAU - Nadarajah, Saralees AU - Nadarajah S AD - Department of Mathematics, University of Manchester, Manchester, United Kingdom. LA - eng PT - Journal Article DEP - 20260930 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13661310 OTO - NOTNLM OT - Somalia OT - exclusive breastfeeding OT - infant nutrition OT - multilevel analysis OT - risk factors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/15 13:35 MHDA- 2026/10/15 13:36 PMCR- 2026/09/30 CRDT- 2026/10/15 07:02 PHST- 2026/07/22 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/15 13:36 [medline] PHST- 2026/10/15 13:35 [pubmed] PHST- 2026/10/15 07:02 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - 10.3389/fnut.2026.1945737 [doi] PST - epublish SO - Front Nutr. 2026 Sep 30;13:1945737. doi: 10.3389/fnut.2026.1945737. eCollection 2026. PMID- 42876325 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261019 IS - 1654-9880 (Electronic) IS - 1654-9716 (Print) IS - 1654-9880 (Linking) VI - 19 IP - 1 DP - 2026 Dec TI - Predicting neurodevelopmental delay among two-year-old infants in Northern Uganda. PG - 2748101 LID - 10.1080/16549716.2026.2748101 [doi] LID - 2748101 AB - BACKGROUND: Data on neurodevelopmental disabilities in sub-Saharan Africa are scarce. Identifying children at the highest risk of neurodevelopmental delay could enable health workers to target these groups more effectively, improve resource allocation and programmatic focus. OBJECTIVE: To develop and assess a model for predicting neurodevelopmental delay among two-year-old infants in Northern Uganda using easily obtainable predictors. METHODS: We studied children born to women enrolled in a cluster randomized controlled trial (January 2018-March 2019) evaluating the effect of peer counseling on health facility births. At the trial's final visit (day 50), 1,804 children were enrolled. In November 2020, we followed up 1,421 children (78.8%) and assessed their neurodevelopment at 2 years using the Malawi Developmental Assessment Tool. We used least absolute shrinkage and selection operator penalized regression with 10-fold cross-validation to select the best subset of predictors and assessed model performance using the area under the curve (AUC). RESULTS: Of the 1,421 children, 70 (4.9%; 95% CI: 3.6-6.7%) had neurodevelopmental delays. Of the 19 candidate predictors, six were retained in the final model (lambda = 0.0076): moderate wasting, prolonged neonatal hospitalization (up to 28 days), maternal education, place of birth, preterm birth, and absence of skin-to-skin contact at birth. The model showed strong discriminative power (AUC 0.75) and reasonable calibration (calibration slope 1.37; calibration belt 0.536-0.727). CONCLUSION: We developed a promising tool for identifying infants at increased risk of neurodevelopmental delay in low-resource settings, which could help prioritize children for follow-up and specialized interventions. FAU - Mukunya, David AU - Mukunya D AUID- ORCID: 0000-0002-3892-9777 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. AD - Department of Research, Nikao Medical Center, Kampala, Uganda. FAU - Ndeezi, Grace AU - Ndeezi G AD - Department of Paediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Namazzi, Gertrude AU - Namazzi G AD - Department of Paediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. AD - Department of Health Policy, Planning and Management, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Tylleskar, Thorkild AU - Tylleskar T AUID- ORCID: 0000-0003-4801-4324 AD - Center for Internation Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. FAU - Nambozo, Brendah AU - Nambozo B AUID- ORCID: 0009-0002-8600-8654 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. AD - Center for Internation Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. FAU - Musaba, Milton W AU - Musaba MW AD - Department of Obstetrics and Gynaecology, Busitema University Faculty of Health Sciences, Mbale, Uganda. FAU - Odongkara, Beatrice AU - Odongkara B AD - Department of Paediatrics and Child Health, Gulu University, Gulu, Uganda. FAU - Achora, Vincentina AU - Achora V AD - Department of Obstetrics and Gynaecology, Gulu University, Gulu, Uganda. FAU - Tongun, Justin Bruno AU - Tongun JB AD - Department of Paediatrics and Child Health, University of Juba, Juba, South Sudan. FAU - Tumuhamye, Josephine AU - Tumuhamye J AUID- ORCID: 0000-0001-5451-6406 AD - Department of Research, Makerere University Hospital, Kampala, Uganda. FAU - Napyo, Agnes AU - Napyo A AUID- ORCID: 0000-0003-4333-3588 AD - Department of Nursing, School of Medicine, Kabale University, Kabale, Uganda. FAU - Ssentumbwe, Vicent AU - Ssentumbwe V AD - Division of Computational and Data Science, Washington University in St. Louis, St. Louis, MO, USA. FAU - Nankabirwa, Victoria AU - Nankabirwa V AD - Centre for Intervention Science and Maternal Child Health (CISMAC), Centre for International Health, University of Bergen, Bergen, Norway. AD - Department of Epidemiology and Biostatistics, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Tumwine, James K AU - Tumwine JK AD - Department of Paediatrics and Child Health, Kabale University, Kabale, Uganda. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20261015 PL - United States TA - Glob Health Action JT - Global health action JID - 101496665 SB - IM MH - Humans MH - Uganda/epidemiology MH - Female MH - Male MH - Child, Preschool MH - *Developmental Disabilities/epidemiology/diagnosis MH - *Neurodevelopmental Disorders/epidemiology MH - Risk Factors MH - Infant PMC - PMC13674651 OAB - Main findings: we developed and evaluated a risk prediction model that identified six readily available factors associated with neurodevelopmental delay among infants in Northern Uganda and demonstrated a good ability to distinguish children at increased risk.Added knowledge: this study provides evidence that routinely collected maternal, birth, and early infant characteristics can be used to support early identification of children who may benefit from targeted neurodevelopmental follow-up.Global health impact for policy and action: the findings provide a practical approach for low-resource settings to improve early detection, prioritize limited resources, and guide interventions to reduce the burden of neurodevelopmental disabilities. OABL- eng OTO - NOTNLM OT - Early child development; thriving OT - human capacity development OT - human capital OT - low-income countries OT - neurodevelopmental delay OT - risk stratification COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:19 PMCR- 2026/10/15 CRDT- 2026/10/15 03:53 PHST- 2026/10/15 07:19 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/15 03:53 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - 2748101 [pii] AID - 10.1080/16549716.2026.2748101 [doi] PST - ppublish SO - Glob Health Action. 2026 Dec;19(1):2748101. doi: 10.1080/16549716.2026.2748101. Epub 2026 Oct 15. PMID- 42876122 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 0004-0614 (Print) IS - 0004-0614 (Linking) VI - 79 IP - 8 DP - 2026 Sep TI - Early Postoperative Testicular Volume Ratio Is Associated With Long-Term Growth Failure After Unilateral Redo Orchiopexy in Children. PG - 1311-1320 LID - 10.56434/j.arch.esp.urol.aeu039 [doi] AB - BACKGROUND: Redo orchiopexy is usually evaluated based on the position of the scrotum after surgery, but satisfactory scrotal placement may not necessarily reflect preserved long-term testicular growth. In this study, we evaluated whether the early postoperative testicular volume ratio (TVR) is associated with long-term growth failure after unilateral redo orchiopexy in children. METHODS: This retrospective single-center cohort study included children who underwent unilateral redo orchiopexy between January 2013 and January 2023. Early postoperative ultrasonography was performed 6-12 months after surgery, and subsequent follow-up ultrasonography was performed at >/=24 months. TVR was calculated as the operated testicular volume divided by the contralateral testicular volume x 100. Long-term growth failure was defined as long-term TVR <50% and/or the absence of an interval increase in operated testicular volume beyond expected ultrasonographic measurement variability. The discriminative ability of early TVR was assessed using receiver operating characteristic (ROC) analysis. The ROC-derived cutoff was considered exploratory because it was derived and evaluated in the same cohort. RESULTS: Sixty-eight children met the inclusion criteria. The mean age at redo orchiopexy was 7.8 +/- 2.9 years, and the median follow-up was 36 months. Long-term growth failure occurred in 20 patients (29.4%). Children with growth failure had significantly lower early TVR than those with preserved growth (48.6 +/- 13.2% vs. 80.4 +/- 16.8%, p < 0.001). Early TVR showed good apparent discrimination, with an area under the curve (AUC) of 0.84 (95% confidence interval [CI], 0.72-0.96). In the exploratory multivariable model, each 10-percentage-point increase in early TVR was associated with a lower odds of growth failure (odds ratio [OR] 0.56; 95% bootstrap CI 0.36-0.84). The apparent model AUC was 0.86, and the optimism-corrected AUC after 1000 bootstrap resamples was 0.81. The exploratory 55% cutoff yielded 82% sensitivity, 78% specificity, 69% positive predictive value, and 88% negative predictive value. CONCLUSIONS: Early postoperative TVR is associated with long-term testicular growth failure after unilateral redo orchiopexy. A TVR of approximately 55% may help identify children who require closer ultrasonographic surveillance, but this threshold is hypothesis-generating and requires external validation before clinical implementation. TVR should be interpreted as an imaging-based risk stratification marker rather than a direct measure of endocrine, fertility, or histologic testicular function. CI - (c) 2026 The Author(s). FAU - Baltrak, Yusuf Atakan AU - Baltrak YA AD - Department of Pediatric Urology, Adana City Education and Research Hospital, 01370 Adana, Turkiye. FAU - Turker Colak, Selcan AU - Turker Colak S AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Tutus, Kamuran AU - Tutus K AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Kilic, Seref Selcuk AU - Kilic SS AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Ozden, Onder AU - Ozden O AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Alkan, Murat AU - Alkan M AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Tuncer, Recep AU - Tuncer R AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. LA - eng PT - Journal Article PL - Spain TA - Arch Esp Urol JT - Archivos espanoles de urologia JID - 0064757 SB - IM MH - Humans MH - Male MH - *Orchiopexy/adverse effects/methods MH - Retrospective Studies MH - Organ Size MH - *Testis/growth & development/diagnostic imaging/pathology/anatomy & histology MH - Reoperation MH - Child, Preschool MH - *Cryptorchidism/surgery MH - Time Factors MH - Ultrasonography MH - Cohort Studies OTO - NOTNLM OT - cryptorchidism OT - redo orchiopexy OT - testicular growth failure OT - testicular volume ratio OT - ultrasonography COIS- All authors have completed the ICMJE uniform disclosure form. The authors have no conflicts of interest to declare. A preprint version of this study was previously posted online under the title "Early Testicular Volume Ratio Predicts Growth Failure after Redo Orchiopexy in Children" (DOI: 10.21203/rs.3.rs-9876005/v1; URL: https://doi.org/10.21203/rs.3.rs-9876005/v1. EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:19 CRDT- 2026/10/15 02:13 PHST- 2026/10/15 07:19 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/15 02:13 [entrez] AID - 10.56434/j.arch.esp.urol.aeu039 [doi] PST - ppublish SO - Arch Esp Urol. 2026 Sep;79(8):1311-1320. doi: 10.56434/j.arch.esp.urol.aeu039. PMID- 42876010 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261023 IS - 1643-3750 (Electronic) IS - 1234-1010 (Print) IS - 1234-1010 (Linking) VI - 32 DP - 2026 Oct 15 TI - Validation of the Children and Adolescents Physical Activity and Sedentary Questionnaire (CAPAS-Q) in Polish Children and Adolescents. PG - e953567 LID - 10.12659/MSM.953567 [doi] LID - e953567 AB - BACKGROUND Global public health faces challenges related to low physical activity (PA) and excessive sedentary behavior (SB) among youth. This study aimed to validate the Polish version of the Children and Adolescents Physical Activity and Sedentary Questionnaire (CAPAS-Q). MATERIAL AND METHODS The study involved 206 participants (114 girls, 92 boys) aged 8 to 17 years. Participants completed the CAPAS-Q twice (7-day interval) to assess test-retest reliability. Objective PA and SB data were collected concurrently using ActiGraph wGT3X-BT accelerometers. Psychometric evaluation included internal consistency (Cronbach's alpha), test-retest reliability (intraclass correlation coefficient [ICC]), and criterion validity (Spearman's rank correlation [rs]). RESULTS Internal consistency was acceptable (Cronbach's alpha 0.674 for PA and 0.754 for SB). Test-retest reliability was good to excellent, with subscale ICCs of 0.7429 to 0.9375. For criterion validity, the SB dimension showed moderate correlations with accelerometer-derived total PA (rs=-0.41) and sedentary time (rs=0.41). PA subscale correlations were generally smaller, with the highest association found between sports/leisure PA and moderate to vigorous PA (rs=0.27). Psychometric properties varied by group, with lower PA validity in younger children and adolescent girls. CONCLUSIONS The Polish CAPAS-Q demonstrates good to excellent test-retest reliability, although its internal consistency varies across subgroups, being lower in younger children. While the tool shows moderate criterion validity for SBs, its validity for quantifying PA volume is weak. Nevertheless, the CAPAS-Q provides valuable contextual and qualitative data. It is recommended as a cost-effective instrument for contextual screening in epidemiological studies, but caution is advised when interpreting PA levels in younger children and adolescent girls. FAU - Baran, Rafal AU - Baran R AUID- ORCID: 0000-0001-9638-9505 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. FAU - Baran, Joanna AU - Baran J AUID- ORCID: 0000-0001-8354-1651 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. FAU - Leszczak, Justyna AU - Leszczak J AUID- ORCID: 0000-0001-8769-0048 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. FAU - Fillon, Alicia AU - Fillon A AUID- ORCID: 0000-0002-0614-8909 AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), EA 3533, Clermont Auvergne University, CRNH Auvergne, Clermont-Ferrand, France. AD - National Observatory for Physical Activity and Sedentary Behaviors (ONAPS), UFR Medicine, University Clermont Auvergne, Clermont-Ferrand, France. FAU - Thivel, David AU - Thivel D AUID- ORCID: 0000-0003-4687-3555 AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), EA 3533, Clermont Auvergne University, CRNH Auvergne, Clermont-Ferrand, France. AD - National Observatory for Physical Activity and Sedentary Behaviors (ONAPS), UFR Medicine, University Clermont Auvergne, Clermont-Ferrand, France. FAU - Wyszynska, Justyna AU - Wyszynska J AUID- ORCID: 0000-0002-5786-6214 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. LA - eng PT - Journal Article PT - Validation Study DEP - 20261015 PL - United States TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental and clinical research JID - 9609063 SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Sedentary Behavior MH - Poland MH - Surveys and Questionnaires MH - *Exercise/physiology/psychology MH - Male MH - Reproducibility of Results MH - Psychometrics/methods MH - Accelerometry/methods PMC - PMC13685572 COIS- Conflict of interest: None declared EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:19 PMCR- 2026/10/15 CRDT- 2026/10/15 01:22 PHST- 2026/10/15 07:19 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/15 01:22 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - 953567 [pii] AID - 10.12659/MSM.953567 [doi] PST - epublish SO - Med Sci Monit. 2026 Oct 15;32:e953567. doi: 10.12659/MSM.953567. PMID- 42875715 OWN - NLM STAT- Publisher LR - 20261014 IS - 1543-0154 (Electronic) IS - 0885-8195 (Linking) DP - 2026 Oct 15 TI - Integrating Physical Activity and Family Health Education into Pediatric Oncology Outpatient Care: ATIVAONCO Project. LID - 10.1007/s13187-026-02999-7 [doi] AB - ATIVAONCO is a university extension project designed to integrate adapted physical activity and family health education into routine pediatric oncology outpatient care in a public hospital in southern Brazil. This descriptive experience report summarizes the program's implementation from 2023 onward. Activities are offered twice weekly during a two-hour outpatient window and are delivered by exercise professionals and supervised trainees. Each session combines a brief health-education component for parents and caregivers, playful and adaptable movement activities for children and adolescents, and a closing discussion circle. Program monitoring uses team observations, participant and caregiver feedback, and session records to support iterative adaptation. Over the years, more than 300 children and adolescents participated in the project, with a mean age of 7.53 +/- 3.30 years; 53.2% were male and 46.8% were female. Recurring observations included engagement with movement activities, social interaction, and use of the waiting area as a more active and welcoming space. ATIVAONCO project demonstrates the practical feasibility of embedding physical activity promotion and family-centered education into outpatient pediatric oncology care. Future evaluations should measure educational outcomes, physical activity exposure, patient-reported outcomes, and safety using standardized prospective methods. CI - (c) 2026. The Author(s). FAU - Carminatti, Micheli AU - Carminatti M AUID- ORCID: 0000-0001-8926-8211 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Cappellaro, Erica AU - Cappellaro E AUID- ORCID: 0009-0006-7907-1427 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Benitez, Herber Orlando AU - Benitez HO AUID- ORCID: 0009-0009-6891-3598 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Wolin, Ingrid Alessandra Victoria AU - Wolin IAV AUID- ORCID: 0000-0002-2156-0715 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. ingridwolin@gmail.com. FAU - Lana, Isadora Dalla AU - Lana ID AUID- ORCID: 0009-0009-5122-5326 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Mohamed, Gustavo Vieira AU - Mohamed GV AUID- ORCID: 0009-0006-8126-6485 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Ramos, Julia de Lima AU - Ramos JL AUID- ORCID: 0009-0000-2007-147X AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Delevatti, Rodrigo Sudatti AU - Delevatti RS AUID- ORCID: 0000-0003-1827-7799 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Gerage, Aline Mendes AU - Gerage AM AUID- ORCID: 0000-0002-0555-5422 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Freitas, Cintia de la Rocha AU - Freitas CR AUID- ORCID: 0000-0001-8566-6298 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. LA - eng PT - Journal Article DEP - 20261015 PL - England TA - J Cancer Educ JT - Journal of cancer education : the official journal of the American Association for Cancer Education JID - 8610343 SB - IM OTO - NOTNLM OT - Cancer education OT - Family-centered care OT - Health education OT - Pediatric oncology OT - Physical activity OT - Supportive care COIS- Declarations. Ethical approval: The ATIVAONCO Project was approved by the Human Research Ethics Committee of the Federal University of Santa Catarina (Approval No. 6,663,135) and by the Human Research Ethics Committee of the Joana de Gusmao Children's Hospital (Approval No. 6,946,800). All procedures were conducted in accordance with the ethical principles applicable to research involving human participants Consent to participate: Written informed consent was obtained from the parents or legal guardians of participating children and adolescents, and assent was obtained from the participants when applicable, according to age and capacity for understanding and in accordance with the procedures approved by the Research Ethics Committees. Consent to publish: Not applicable. The manuscript does not contain identifiable individual participant data, images, or other information requiring consent for publication. Relevance to cancer education: ATIVAONCO integrates family-centered education on physical activity and healthy behaviors into routine pediatric oncology outpatient care while providing a supervised practice setting for exercise-science trainees. This report describes the implementation of a cancer-care education strategy at patient-family and trainee levels; educational learning outcomes were not formally measured. Competing interests: The authors declare that they have no financial or non-financial competing interests relevant to the content of this article. EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:18 CRDT- 2026/10/14 23:55 PHST- 2026/09/10 00:00 [received] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/15 07:18 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/14 23:55 [entrez] AID - 10.1007/s13187-026-02999-7 [pii] AID - 10.1007/s13187-026-02999-7 [doi] PST - aheadofprint SO - J Cancer Educ. 2026 Oct 15. doi: 10.1007/s13187-026-02999-7. PMID- 30000942 STAT- Publisher CTDT- 20261015 PB - National Institute of Child Health and Human Development DP - 2006 TI - Hibiscus. BTI - Drugs and Lactation Database (LactMed(R)) AB - Hibiscus (Hibiscus sabdariffa) flowers contain anthocyanins, proanthocyanidins, flavonols, as well as various pigments, oils and acids. Other Hibiscus species are also used medicinally. Hibiscus is purportedly used as a galactogogue in some cultures and is included in some proprietary mixtures promoted to increase milk supply;[1-4] however, no scientifically valid clinical trials support this use. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[5,6] No data exist on the excretion of any components of Hibiscus into breastmilk or on the safety and efficacy of Hibiscus nursing mothers or infants. Hibiscus is "generally recognized as safe" (GRAS) as a food by the U.S. Food and Drug Administration. Hibiscus flowers appear to be generally well tolerated, although allergic reactions are possible, including cross reaction with other members of the Malvaceae family (e.g., ambrette, marshmallow). Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site. LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Abelmoschus cruentus OT - Furcaria sabdariffa OT - Hibiscus cruentus OT - Hibiscus fraternus OT - Hibiscus palmatilobus OT - Sabdariffa rubra OT - Agua de Jamaica OT - Ambashthaki OT - Bissap OT - Erragogu OT - Flor de Jamaica OT - Florida cranberry OT - Gongura OT - Groseille de Guinee OT - Guinea Sorrel OT - Hibisco OT - Hibiscus Calyx OT - Jamaica Sorrel OT - Karkade OT - Karkade OT - Lo Shen OT - Oseille de Guinee OT - Oseille Rouge OT - Pulicha Keerai OT - Red Sorrel OT - Red Tea OT - Rosa de Jamaica OT - Rosella OT - Roselle OT - Sour Tea OT - Sudanese Tea OT - Te de Jamaica OT - The Rose d'Abyssinie OT - The Rouge OT - Zobo OT - Zobo Tea EDAT- 2026/10/15 00:00 CRDT- 2026/10/15 00:00 AID - NBK501882 [bookaccession] PMID- 30000876 STAT- Publisher CTDT- 20261015 PB - National Institute of Child Health and Human Development DP - 2006 TI - Goat's Rue. BTI - Drugs and Lactation Database (LactMed(R)) AB - Goat's rue (Galega officinalis) leaves and flowering tops contain numerous guanidine derivatives, including galegine which may cause hypoglycemia. Goat's rue is widely used internationally as a galactogogue.[1-5] No scientifically valid clinical trials support this use, although some old, poorly controlled studies found an effect. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[6,7] Although it has a long history of use as a galactogogue, very limited scientific data exist on the safety and efficacy of goat's rue in nursing mothers or infants. In general, goat's rue is well tolerated, but it might cause hypoglycemia, so caution should be used in women taking antidiabetic drugs. Diarrhea and hepatomegaly occurred in a woman taking fennel, fenugreek, and goat's rue as galactogogues, and slightly elevated transaminases occurred in a woman taking goat's rue, torbangun, and fenugreek that reversed when goat's rue and torbangun were discontinued.[8,9] Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site. LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Galega extract OT - Goat's rue OT - Extract of galega OT - Goat's rue extract OT - Extract of goat's rue OT - Galega officinalis, ext. OT - EINECS 283-487-4 EDAT- 2026/10/15 00:00 CRDT- 2026/10/15 00:00 AID - NBK501817 [bookaccession] PMID- 30000867 STAT- Publisher CTDT- 20261015 PB - National Institute of Child Health and Human Development DP - 2006 TI - Chamomile. BTI - Drugs and Lactation Database (LactMed(R)) AB - Two different plant species with similar effects are known as chamomile: German chamomile (Matricaria recutita) and Roman chamomile (Chamaemelum nobile). Both contain similar ingredients, including sesquiterpenes (e.g., bisabolol, farnesene), sesquiterpenelactones (e.g., chamazulene, matricin), flavonoids (e.g., apigenin, luteolin), and volatile oils. Chamomile is used orally as a sedative and for gastrointestinal conditions; it is used topically for wound healing. Both herbal and homeopathic preparations have been used to treat mastitis and cracked, bleeding nipples.[1,2] Chamomile has been used as a galactogogue and is included in some herbal mixtures promoted for lactation;[3-5] however, no scientifically valid clinical trials support this use. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[6,7] Chamomile is "generally recognized as safe" (GRAS) for use in food by the U.S. Food and Drug Administration as a spice, seasoning, or flavoring agent. No data exist on the safety of chamomile in nursing mothers or infants, although rare sensitization may occur (see below).[8] It has been safely and effectively used alone and with other herbs in infants for the treatment of colic, diarrhea, and other conditions,[9-12] so the smaller amounts expected (but not demonstrated) in breastmilk are likely not to be harmful with usual maternal doses. Note that Clostridium botulinum (botulism) spores have been found in some loose-leaf chamomile teas sold in health food stores. Topical chamomile is a known sensitizing agent, even with homeopathic products.[13] Two women developed contact dermatitis of the nipples and areolas after applying Kamillosan ointment for cracked nipples. The product was purchased in England and contained 10.5% Roman chamomile extracts and oil. Reactions were confirmed to be caused by Roman chamomile by patch testing in both women. Drinking chamomile tea can exacerbate topical skin rashes and has caused anaphylaxis in sensitized individuals.[14,15] Chamomile has possible cross-reactivity with other members of the aster family (e.g., echinacea, feverfew, and milk thistle).[8] Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site. LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Kamillenoel OT - Chamomile OT - Matricaria oil OT - Oil of matricaria OT - Blue chamomile oil OT - Wild chamomile oil OT - Chamomile Blue oil OT - Camomile oil german OT - German camomile oil OT - Chamomile oil, blue OT - Chamomile oil, wild OT - Chamomile-german oil OT - German chamomile oil OT - German chamonile oil OT - Oil german chamomile OT - Kamillenoel [German] OT - Chamomile oil, german OT - Hungarian chamomile oil OT - Oils, chamomile,german OT - Caswell No. 167E OT - Camomile oil, hungarian OT - Chamomile oil [German] OT - German chamomile extract OT - Chamomile oil, Hungarian OT - Oils, chamomile, german OT - FEMA No. 2273 OT - Chamomile flower oil, Hungarian OT - UNII-60F80Z61A9 OT - EPA Pesticide Chemical Code 128853 OT - Matricaria chamomilla flowering top oil OT - Chamomile flower OT - Matricaria chamomilla L. EDAT- 2026/10/15 00:00 CRDT- 2026/10/15 00:00 AID - NBK501808 [bookaccession] PMID- 30000851 STAT- Publisher CTDT- 20261015 PB - National Institute of Child Health and Human Development DP - 2006 TI - Coriander. BTI - Drugs and Lactation Database (LactMed(R)) AB - Coriander (Coriandrum sativum) seeds contain a volatile oil, consisting mainly of linalool, which is responsible for its odor and taste. It also contains 1,8-cineole (eucalyptol). Coriander is a purported galactogogue, and has been included in some mixtures promoted to increase milk supply;[1-3] however, no scientifically valid clinical trials support this use. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[1,4] Coriander is "generally recognized as safe" (GRAS) as a food by the U.S. Food and Drug Administration. However, allergic reactions and photosensitivity have been reported, and it can cause contact dermatitis. One case of excessive use possibly caused endocrine disruption in a nursing mother. A woman nursing her 10-month-old infant had drunk 200 mL of about a 10% aqueous extract of Coriandrum sativa (method of verification and possible presence of contaminants not stated) daily for 7 consecutive days to enhance her milk supply when she was admitted to the hospital with severe diarrhea and stomach pain. The patient had no abnormal serum or urine tests and recovered with palliative therapy. Fifteen days later the patient was complaining of skin darkness, depressed mood, a loss of body fluids, and amenorrhea, which was diagnosed as an adrenal dysfunction. The patient said that she did not have any history of such a condition. She was treated with adrenocorticoids and an oral contraceptive. She was well and healthy 10 days later.[2] Elevated liver enzymes occurred in a woman taking Mother's Milk Tea, which contains coriander.[5] Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site. LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Coriandrum OT - Cilantro OT - Coriander OT - Coriandrum sativum extract OT - FEMA No. 2333 OT - EINECS 283-880-0 EDAT- 2026/10/15 00:00 CRDT- 2026/10/15 00:00 AID - NBK501792 [bookaccession] PMID- 30000850 STAT- Publisher CTDT- 20261015 PB - National Institute of Child Health and Human Development DP - 2006 TI - Caraway. BTI - Drugs and Lactation Database (LactMed(R)) AB - Caraway (Carum carvi) seeds contain numerous volatile oils, the most prominent being carvone and limonene. Caraway is a purported galactogogue and is included in some lactation teas,[1-8] but it has also been used to decrease breastmilk oversupply in Persian traditional medicine.[9] Maternal use has been advocated to reduce colic in the breastfed infant.[10] No scientifically valid clinical trials support these uses, although one small, old study found no galactogogue effect. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[11] Two studies found small, but measurable amounts of d-carvone in the milk of mothers given the chemical experimentally. Caraway is "generally recognized as safe" by the U.S. Food and Drug Administration. It is usually well tolerated, with the primary side effects being gastrointestinal such as heartburn, eructation, flatulence, and nausea. In two studies nursing mothers were given d-carvone. No adverse effects were noted in mothers or infants. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site. LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) EDAT- 2026/10/15 00:00 CRDT- 2026/10/15 00:00 AID - NBK501791 [bookaccession] PMID- 30000835 STAT- Publisher CTDT- 20261015 PB - National Institute of Child Health and Human Development DP - 2006 TI - Anise. BTI - Drugs and Lactation Database (LactMed(R)) AB - Anise (Pimpinella anisum) seeds contain anethole, which is a phytoestrogen as well as chlorogenic acid, naringenin, gallic acid, ellagic acid, taxifolin, coffeic acid, syringic acid, eugenol, trans-anethole, cis-anethole, methylchavicol, anisaldehyde, estragole, anisketone, linalool, coumarins, catechins, scopeletin, umbelliferone, estrols, and beta-farnesene. Anise is a purported galactogogue,[1-8] and is included in some proprietary mixtures promoted to increase milk supply; however, few scientifically valid clinical trials support this use. A meta-analysis concluded that anise produced a small increase in milk volume compared to no treatment on day 1 postpartum and there is low certainty evidence that anise tea increases milk volume on day 7.[9] Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[10,11] Maternal anise ingestion reportedly imparts an odor to breastmilk,[12] possibly because anethole is excreted into breastmilk.[13] Studies on the exposure of nursing infants to cinnamon odor found no effect on growth parameters, whereas maternal odor and maternal milk odor may have an effect on infant weight gain.[14] Anise is "generally recognized as safe" (GRAS) as a flavoring by the U.S. Food and Drug Administration. Elevated liver enzymes occurred in a woman taking Mother's Milk Tea, which contains anise.[15] Excessive maternal use of an herbal tea containing anise and other herbs appeared to cause toxicity in two breastfed newborns, consistent with toxicity caused by anethole. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site. LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Anise OT - Pimpinella anisum OT - anis OT - anis OT - anis vert OT - aniseed OT - anisi fructus OT - graine d'anis vert OT - green anise OT - huile essentielle d'anis OT - pinella OT - semen anisi OT - shatpushpa OT - sweet cumin OT - velaiti saunf EDAT- 2026/10/15 00:00 CRDT- 2026/10/15 00:00 AID - NBK501776 [bookaccession] PMID- 42874351 OWN - NLM STAT- Publisher LR - 20261014 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 149 IP - 3 DP - 2026 Oct 11 TI - Breastfeeding infants with inherited metabolic disorders: review of current strategies and practical recommendations to overcome challenges. PG - 110294 LID - S1096-7192(26)00577-9 [pii] LID - 10.1016/j.ymgme.2026.110294 [doi] AB - Human milk feeding (HMF), through direct breastfeeding (BF) and expressed HM, is the optimal source of infant nutrition, yet practical guidance for inherited metabolic disorders (IMDs) remains limited outside phenylketonuria (PKU). This review summarises strategies, challenges, and clinical considerations for implementing HMF across IMDs requiring dietary modification. A comprehensive search identified studies reporting practical aspects of HMF in disorders of amino acid metabolism, organic acidaemias, urea cycle disorders, fatty acid oxidation disorders, and peripheral galactose epimerase deficiency. Data were synthesised qualitatively. Fifty-one publications describing 1470 infants were included. Successful HMF was reported across all disorders in scope, although feeding strategies varied. In asymptomatic infants, BF on demand was broadly feasible, typically combined with appropriate medical infant formula. In symptomatic infants at diagnosis, BF was generally temporarily interrupted during acute management and reintroduced during a transition phase using controlled volumes of expressed HM and medical infant formula. Re-establishment of BF on demand was possible in many, but not all, infants. Key challenges to BF included maternal anxiety, poor feeding at birth for symptomatic infants and during acute illness, need for complex feeding regimens, frequent hospitalisations in severe IMDs, prematurity, and insufficient HM supply. Successful HMF depended on close disorder-specific metabolic biochemical and growth monitoring with regular adjustment of dietary prescriptions. Maintaining lactation required early, structured support of mothers. HMF is feasible across many IMDs when integrated into individualised, risk-stratified feeding plans. Multidisciplinary support is crucial. Greater standardisation of reporting and wider dissemination of clinical experience are needed to strengthen future recommendations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Holler, Alexander AU - Holler A AD - Division of Nutrition and Dietetics, University Hospital Innsbruck, Innsbruck, Austria; Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT TIROL-University for Health Sciences and Technology, Hall in Tirol, Austria; Digital Health Information Systems, Centre for Health & Bioresources, AIT Austrian Institute of Technology, Graz, Austria. FAU - Ilgaz, Fatma AU - Ilgaz F AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey. FAU - Marsaux, Cyril AU - Marsaux C AD - Danone Research & Innovation, Utrecht, the Netherlands. Electronic address: cyril.marsaux@danone.com. FAU - Banta-Wright, Sandra AU - Banta-Wright S AD - School of Nursing, Oregon Health & Science University, Portland, Oregon, United States of America. FAU - Coskun, Turgay AU - Coskun T AD - Department of Pediatric Metabolism and Nutrition, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Dixon, Marjorie AU - Dixon M AD - Dietetics, Great Ormond Street Hospital for Children, London, UK. FAU - Jorg-Streller, Monika AU - Jorg-Streller M AD - Division of Nutrition and Dietetics, University Hospital Innsbruck, Innsbruck, Austria. FAU - Newby, Camille AU - Newby C AD - Department of Nutrition and Dietetics, Bristol Royal Hospital for Children, Bristol, UK. FAU - Singh, Rani AU - Singh R AD - Department of Human Genetics and Pediatrics, Emory University School of Medicine, Atlanta, GA, United States of America. FAU - Stahl, Bernd AU - Stahl B AD - Danone Research & Innovation, Utrecht, the Netherlands; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands. FAU - Vitoria-Minana, Isidro AU - Vitoria-Minana I AD - Metabolic and Nutrition Unit, Hospital Universitari i Politecnic la Fe, Valencia, Spain. FAU - van Wegberg, Annemiek AU - van Wegberg A AD - Division of Metabolic Diseases, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands; Department of Gastroenterology and Hepatology-Dietetics, Radboud University Medical Centre, Nijmegen, the Netherlands. FAU - Woestenenk, Willie AU - Woestenenk W AD - Danone Research & Innovation, Utrecht, the Netherlands. FAU - MacDonald, Anita AU - MacDonald A AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham, UK. FAU - Karall, Daniela AU - Karall D AD - Department of Pediatrics I, Division of Inherited Metabolic Disorders, Medical University of Innsbruck, Innsbruck, Austria. LA - eng PT - Journal Article PT - Review DEP - 20261011 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 SB - IM OTO - NOTNLM OT - Breast milk OT - Human milk OT - Inborn errors of metabolism OT - Metabolic diseases OT - PKU COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Alexander Hoeller reports financial support and article publishing charges were provided by Danone Global Research & Innovation Center BV. Fatma Ilgaz reports financial support was provided by Danone Global Research & Innovation Center BV. Marjorie Dixon reports a relationship with Danone Global Research & Innovation Center BV that includes: travel reimbursement. Marjorie Dixon reports a relationship with Vitaflo International Ltd. that includes: travel reimbursement. Marjorie Dixon reports a relationship with Immedica Pharma AB that includes: travel reimbursement. Marjorie Dixon reports a relationship with Ultragenyx Pharmaceutical Inc. that includes: travel reimbursement. Camille Newby reports a relationship with Danone Global Research & Innovation Center BV that includes: travel reimbursement. Camille Newby reports a relationship with Vitaflo International Ltd. that includes: travel reimbursement. Rani Singh reports a relationship with BioMarin Pharmaceutical Inc. that includes: funding grants. Rani Singh reports a relationship with Amgen Inc. that includes: consulting or advisory. Rani Singh reports a relationship with Arla Foods Ingredients Group PS that includes: consulting or advisory. Rani Singh reports a relationship with Otsuka Pharmaceutical Co Ltd. that includes: consulting or advisory. Annemiek van Wegberg reports a relationship with Danone Global Research & Innovation Center BV that includes: consulting or advisory, funding grants, and speaking and lecture fees. Annemiek van Wegberg reports a relationship with PTC Therapeutics Inc. that includes: consulting or advisory and speaking and lecture fees. Annemiek van Wegberg reports a relationship with Vitaflo International Ltd. that includes: consulting or advisory and speaking and lecture fees. Anita MacDonald reports a relationship with BioMarin Pharmaceutical Inc. that includes: funding grants. Anita MacDonald reports a relationship with PTC Therapeutics Inc. that includes: consulting or advisory, funding grants, and speaking and lecture fees. Anita MacDonald reports a relationship with Danone Global Research & Innovation Center BV that includes: consulting or advisory, funding grants, and speaking and lecture fees. Anita MacDonald reports a relationship with Vitaflo International Ltd. that includes: consulting or advisory, funding grants, and speaking and lecture fees. Anita MacDonald reports a relationship with Ajinomoto Cambrooke, Inc. that includes: funding grants. Anita MacDonald reports a relationship with metaX that includes: funding grants. Anita MacDonald reports a relationship with Relief Therapeutics Holding SA that includes: funding grants. Anita MacDonald reports a relationship with Arla Foods Ingredients Group PS that includes: consulting or advisory, funding grants, and speaking and lecture fees. Anita MacDonald reports a relationship with APR Applied Pharma Research SA that includes: consulting or advisory and speaking and lecture fees. Cyril Marsaux reports a relationship with Danone Global Research & Innovation Center BV that includes: employment. Bernd Stahl reports a relationship with Danone Global Research & Innovation Center BV that includes: employment. Willie Woestenenk reports a relationship with Danone Global Research & Innovation Center BV that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/14 23:32 MHDA- 2026/10/14 23:32 CRDT- 2026/10/14 18:13 PHST- 2026/09/03 00:00 [received] PHST- 2026/09/28 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/14 23:32 [medline] PHST- 2026/10/14 23:32 [pubmed] PHST- 2026/10/14 18:13 [entrez] AID - S1096-7192(26)00577-9 [pii] AID - 10.1016/j.ymgme.2026.110294 [doi] PST - aheadofprint SO - Mol Genet Metab. 2026 Oct 11;149(3):110294. doi: 10.1016/j.ymgme.2026.110294. PMID- 42874253 OWN - NLM STAT- Publisher LR - 20261014 IS - 1532-8171 (Electronic) IS - 0735-6757 (Linking) VI - 110 DP - 2026 Oct 7 TI - Resuscitation training with school children - Analysis of factors affecting chest compression quality. PG - 592-596 LID - S0735-6757(26)00530-9 [pii] LID - 10.1016/j.ajem.2026.10.005 [doi] AB - BACKGROUND: Early bystander cardiopulmonary resuscitation (CPR) improves survival after sudden cardiac arrest, but bystander CPR rates remain low. International guidelines therefore recommend CPR training during childhood. This study evaluated CPR performance in children aged 8-13 years and assessed determinants of chest compression quality. METHODS: In this observational cross-sectional study (2019-2022), 784 schoolchildren aged 8-13 years completed a standardized 90-min CPR training session. Anthropometric data and CPR quality parameters were recorded using Resusci Anne QCPR Torso manikins (Laerdal Medical AS, Starvanger, Norway) and SimPad Plus SkillReporter systems (Laerdal Medical AS, Starvanger, Norway). Associations were analyzed using multivariate statistics. RESULTS: A total of 784 children (mean age 11 +/- 1 years) were included. Two minutes of chest compressions were completed by 93% of children. Mean compression depth was 40.0 +/- 9.9 mm and correlated with weight (r = 0.663), height (r = 0.623), and age (r = 0,544; all p < .001). In multivariable analysis, these factors explained 50% of variance (R(2) = 0.50, p < .001). Mean compression rate (115 +/- 8/min) was higher in younger children and became more consistent with increasing age (ss = -0.119, p = .02). Correct hand positioning was achieved almost universally (median 100%). CONCLUSION: A tailored and focused CPR training is feasible and effective in children aged 8-13 years but higher body weight improves compression depth, older age improves compression, while correct hand position is largely independent of these variables. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Reese, Lena AU - Reese L AD - University Hospital Wurzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Section Emergency and Disaster Medicine, Wurzburg, Germany. Electronic address: Reese_L2@ukw.de. FAU - Horlin, Ines AU - Horlin I AD - Wurzburg Mitte Hospital, Juliusspital Site, Department of General and Visceral Surgery, Wurzburg, Germany. Electronic address: ines.hoerlin@kwm-klinikum.de. FAU - Kippnich, Maximilian AU - Kippnich M AD - University Hospital Wurzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Section Emergency and Disaster Medicine, Wurzburg, Germany. Electronic address: Kippnich_M@ukw.de. FAU - Meybohm, Patrick AU - Meybohm P AD - University Hospital Wurzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Section Emergency and Disaster Medicine, Wurzburg, Germany. Electronic address: Meybohm_P@ukw.de. FAU - Wurmb, Thomas AU - Wurmb T AD - University Hospital Wurzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Section Emergency and Disaster Medicine, Wurzburg, Germany. Electronic address: Wurmb_t@ukw.de. LA - eng PT - Journal Article DEP - 20261007 PL - United States TA - Am J Emerg Med JT - The American journal of emergency medicine JID - 8309942 SB - IM OTO - NOTNLM OT - CPR OT - Compression depth OT - Resuscitation training OT - SCHOOL children COIS- Declaration of competing interest The authors declare that this study was supported by a grant from Universitatsbund Wurzburg e.V. EDAT- 2026/10/14 23:31 MHDA- 2026/10/14 23:31 CRDT- 2026/10/14 18:08 PHST- 2026/06/19 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/14 23:31 [medline] PHST- 2026/10/14 23:31 [pubmed] PHST- 2026/10/14 18:08 [entrez] AID - S0735-6757(26)00530-9 [pii] AID - 10.1016/j.ajem.2026.10.005 [doi] PST - aheadofprint SO - Am J Emerg Med. 2026 Oct 7;110:592-596. doi: 10.1016/j.ajem.2026.10.005. PMID- 42874221 OWN - NLM STAT- Publisher LR - 20261014 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 206 DP - 2026 Oct 9 TI - Quantitative ultrasound-derived estimated fat fraction for detection and grading of metabolic dysfunction-associated steatotic liver disease in a pediatric population. PG - 113294 LID - S0720-048X(26)00642-X [pii] LID - 10.1016/j.ejrad.2026.113294 [doi] AB - BACKGROUND: Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is approximately 10%, but ultrasound fat quantification lacks validation. This study evaluated the diagnostic performance of quantitative ultrasound-derived estimated fat fraction (USFF) against magnetic resonance imaging proton density fat fraction (MRI-PDFF) in children with suspected MASLD. METHODS: This prospective single-center study enrolled 65 children aged 6-18 years with suspected MASLD. USFF, tissue attenuation imaging (TAI), tissue scatter distribution imaging (TSI), hepato-renal index (EzHRI), and shear wave elastography (SWE) were measured on a Samsung R10 Prestige platform; 3.0 T MRI-PDFF served as reference. Steatosis was graded using pediatric PDFF thresholds. Diagnostic performance was assessed by ROC analysis with DeLong comparisons and internally validated by bootstrap resampling; agreement by Bland-Altman analysis; inter-operator reproducibility assessed in a randomly selected 30-child subset. RESULTS: Among 65 children (48 boys; median age 11.2 years), 20 were classified as S0, 29 as S1, and 16 as S2-3. USFF AUCs were 0.941 (>/=S1) and 0.960 (>/=S2), higher than EzHRI and SWE, and similar to TAI (0.903, 0.957) and TSI (0.900, 0.880). USFF strongly correlated with MRI-PDFF (rho = 0.906) but systematically underestimated PDFF (mean bias - 3.13%; non-parametric limits of agreement - 14.51% to + 4.24%). In an exploratory analysis, younger children (<12 years) showed larger bias (-4.00% vs - 1.82%, p = 0.029) with similar AUC point estimates. CONCLUSIONS: USFF shows high diagnostic performance (AUC > 0.94) for pediatric MASLD, but its 3.13% underestimation and wide non-parametric limits of agreement warrant caution. USFF may serve as a practical tool for categorical steatosis grading in children with suspected MASLD, and the proposed thresholds require external validation before clinical use. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Wang, Yujue AU - Wang Y AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Du, Lanxin AU - Du L AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Yang, Caiwei AU - Yang C AD - Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wang, Qian AU - Wang Q AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Pang, Houqing AU - Pang H AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. Electronic address: panghouqing75@163.com. FAU - Li, Ping AU - Li P AD - Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: pingli_0415@scu.edu.cn. LA - eng PT - Journal Article DEP - 20261009 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM OTO - NOTNLM OT - Adiposity OT - MASLD OT - Magnetic resonance imaging OT - Pediatric OT - Quantitative ultrasound OT - Ultrasonography COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/14 23:32 MHDA- 2026/10/14 23:32 CRDT- 2026/10/14 18:05 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/10/08 00:00 [accepted] PHST- 2026/10/14 23:32 [medline] PHST- 2026/10/14 23:32 [pubmed] PHST- 2026/10/14 18:05 [entrez] AID - S0720-048X(26)00642-X [pii] AID - 10.1016/j.ejrad.2026.113294 [doi] PST - aheadofprint SO - Eur J Radiol. 2026 Oct 9;206:113294. doi: 10.1016/j.ejrad.2026.113294. PMID- 42873381 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261017 IS - 1435-2451 (Electronic) IS - 1435-2443 (Print) IS - 1435-2443 (Linking) VI - 411 IP - 1 DP - 2026 Oct 13 TI - Ex-vivo right posterior sectionectomy for large-for-size mismatch in pediatric liver transplant recipients. LID - 10.1007/s00423-026-04320-y [doi] LID - 282 AB - PURPOSE: Large-for-size mismatch remains a major challenge in pediatric and small recipient liver transplantation, particularly when full-size deceased-donor grafts are allocated and conventional splitting is not feasible. METHODS: We performed a single-center retrospective analysis of seven pediatric and adolescent recipients who underwent deceased donor liver transplantation (DDLT) with ex-vivo right posterior sectionectomy (RPS) between 2018 and 2022. Grafts were considered oversized based on an integrated surgical assessment including graft-to-recipient weight ratio (GRWR), recipient abdominal anatomy, graft morphology, and expected graft fit. RESULTS: Median GRWR decreased from 4.7% to 2.2%, allowing graft implantation in all cases. Primary abdominal closure was achieved in six recipients, while one required delayed closure for large-for-size syndrome (LFS). No cases of severe LFS with hemodynamic, ventilatory, or graft perfusion compromise were observed. Major complications occurred in three patients, including one biliary complication requiring surgical revision, one primary graft failure requiring retransplantation, and one death unrelated to graft size or transplant surgery. At a median follow-up of 59.5 months among surviving recipients, six of seven patients were alive; five retained their original graft, while one was alive with a functioning second graft after retransplantation. CONCLUSION: Ex-vivo RPS appears to be a technically feasible rescue graft reduction strategy in highly selected pediatric recipients when conventional graft reduction techniques are not feasible. Given the limited cohort size and the occurrence of primary graft failure and mortality, its safety and efficacy require further evaluation. CI - (c) 2026. The Author(s). FAU - Della Penna, Andrea AU - Della Penna A AD - Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Hoppe-Seyler-Strasse 3, 72076, Tubingen, Germany. FAU - Hartleif, Steffen AU - Hartleif S AD - Paediatric Gastroenterology and Hepatology, Department of Haematology and Oncology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Quante, Markus AU - Quante M AD - Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany. FAU - Nadalin, Silvio AU - Nadalin S AD - Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Hoppe-Seyler-Strasse 3, 72076, Tubingen, Germany. Silvio.Nadalin@med.uni-tuebingen.de. LA - eng PT - Journal Article DEP - 20261013 PL - Germany TA - Langenbecks Arch Surg JT - Langenbeck's archives of surgery JID - 9808285 SB - IM MH - Humans MH - *Liver Transplantation/methods MH - Retrospective Studies MH - Female MH - Child MH - Male MH - Adolescent MH - Organ Size MH - Child, Preschool MH - *Hepatectomy/methods MH - Infant MH - Graft Survival MH - Treatment Outcome PMC - PMC13669043 OTO - NOTNLM OT - Graft reduction OT - Large-for-size syndrome OT - Liver transplantation OT - Pediatric transplantation OT - Surgical techniques COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/10/14 18:14 MHDA- 2026/10/14 18:15 PMCR- 2026/10/13 CRDT- 2026/10/14 15:09 PHST- 2026/04/17 00:00 [received] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/14 18:15 [medline] PHST- 2026/10/14 18:14 [pubmed] PHST- 2026/10/14 15:09 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - 10.1007/s00423-026-04320-y [pii] AID - 4320 [pii] AID - 10.1007/s00423-026-04320-y [doi] PST - epublish SO - Langenbecks Arch Surg. 2026 Oct 13;411(1):282. doi: 10.1007/s00423-026-04320-y. PMID- 42873276 OWN - NLM STAT- Publisher LR - 20261014 IS - 1432-198X (Electronic) IS - 0931-041X (Linking) DP - 2026 Oct 14 TI - Feasibility and acceptability of a telehealth-supported physical activity program for children with chronic kidney disease: a pilot mixed methods study. LID - 10.1007/s00467-026-07560-8 [doi] AB - BACKGROUND: Children with chronic kidney disease (CKD) often experience high levels of physical inactivity, exacerbating their health challenges and diminishing their quality of life. Given the potential health risks and reported barriers to sustained engagement in physical activity interventions, our objective was to evaluate the feasibility and acceptability of an individualized telehealth-supported physical activity program for adolescents with CKD stages 2-5. METHODS: This study was a 2-arm randomized waitlist control intervention to evaluate a 12-week telehealth physical activity program in children with CKD. Eligible participants, aged 11-18 years with CKD stages 2-5, were randomized via permuted block randomization, with CKD stage and sex as stratification factors, into a waitlist control (WLC) or physical activity intervention group. The treatment group received every 2-weeks video visits and personalized physical activity plans to increase or maintain >/=150 min of moderate to vigorous physical activity/week. All participants received a remotely tracked fitness wearable. Demographic and disease-based characteristics were collected at baseline to assess group differences. End-of-treatment surveys were conducted to assess acceptability, and inductive qualitative analysis was performed on two open-ended questions for both participant and guardian. RESULTS: Of 400 patients screened for eligibility, 37 were randomized (19 to waitlist control, 18 to treatment) with a recruitment rate of 4/month and an attrition rate of 2.7%. No demographic or disease characteristic differences were observed between groups. High fitness wearable adherence was observed in 35 participants. Median telehealth visit compliance was 83%. Qualitative analysis identified 3 categories: accountability and motivation (>30% citations from participants and parents relating to instructor motivation and accountability), the interplay of physical or mental health and physical activity (44% participant physical health), and personalization of the program to limit barriers to implementation (52% participant activity type, 44% participant education). CONCLUSION: Telehealth-supported physical activity intervention is feasible in children with CKD with low attrition rates and high compliance to visits. Participants and guardians identified personalization and engagement strategies as central to their experience of the program, suggesting these may be important to intervention success. CI - (c) 2026. The Author(s). FAU - Wong Vega, Molly R AU - Wong Vega MR AUID- ORCID: 0000-0003-4732-4996 AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, TX, USA. mvega@bcm.edu. AD - Department of Pediatrics, Section of Pediatric Nephrology, Baylor College of Medicine, Houston, TX, USA. mvega@bcm.edu. AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. mvega@bcm.edu. FAU - Johnston, Craig A AU - Johnston CA AUID- ORCID: 0009-0002-9533-1883 AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. FAU - Bily, Morgan AU - Bily M AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, TX, USA. FAU - Walsh, David W AU - Walsh DW AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. FAU - LaVoy, Emily C AU - LaVoy EC AUID- ORCID: 0000-0002-9505-0144 AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. FAU - Jennings, Kristofer AU - Jennings K AUID- ORCID: 0000-0002-5442-9326 AD - Department of Biostatistics, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. FAU - Akcan-Arikan, Ayse AU - Akcan-Arikan A AUID- ORCID: 0000-0002-5123-6713 AD - Department of Pediatrics, Section of Pediatric Nephrology, Baylor College of Medicine, Houston, TX, USA. AD - Department of Pediatrics, Section of Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA. FAU - Markofski, Melissa M AU - Markofski MM AUID- ORCID: 0000-0003-0214-4246 AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. LA - eng GR - 22-01657/ACSM Foundation/ PT - Journal Article DEP - 20261014 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 SB - IM OTO - NOTNLM OT - Adolescents OT - Compliance OT - Exercise OT - Qualitative OT - Telemedicine COIS- Declarations. Conflict of interest: The authors declare that no competing interests. EDAT- 2026/10/14 18:14 MHDA- 2026/10/14 18:14 CRDT- 2026/10/14 14:56 PHST- 2026/06/04 00:00 [received] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/08/13 00:00 [revised] PHST- 2026/10/14 18:14 [medline] PHST- 2026/10/14 18:14 [pubmed] PHST- 2026/10/14 14:56 [entrez] AID - 10.1007/s00467-026-07560-8 [pii] AID - 10.1007/s00467-026-07560-8 [doi] PST - aheadofprint SO - Pediatr Nephrol. 2026 Oct 14. doi: 10.1007/s00467-026-07560-8. PMID- 42872516 OWN - NLM STAT- Publisher LR - 20261022 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Oct 14 TI - Development of an anthropometric-based algorithm to estimate feeding tube insertion depth in neonates. LID - 10.1002/jpn3.70608 [doi] AB - OBJECTIVE: To develop an anthropometric-based algorithm for estimating feeding tube (FT) insertion depth in neonates using retrospectively collected radiographic data. METHODS: This observational study reviewed records of infants admitted to a Danish level IV Neonatal Intensive Care Unit from January 2023 to December 2024. Infants with FT placement, using the conventional Nose-Ear-Xiphoid (NEX) method, and radiographic verification within 24 h were included. Radiographically verified FT position and anthropometric data were used to develop new linear and multivariate quadratic models to optimize placement. RESULTS: Among 198 infants were included (median gestational age [GA] of 35 + 0 weeks [interquartile range, IQR:28 + 6-38 + 1]), 301 radiographic images showed, 144 FTs located at lumbar vertebra 1 (L1), 139 within one vertebra of L1, and 18 outside the stomach. Radiologists recommended adjustment in 107 images. Linear models (weight- or length-dependent) showed strong predictive power (R(2) > 0.84), while the multivariate quadratic model reduced bias and achieved R(2) = 0.88, confirmed by cross-validation. Prediction accuracy within the predefined target range (L1 +/- 1.5 cm) was 77% n, compared with 64% of clinically acceptable NEX placed tubes (p < 0.001). The optimal algorithm was: FT depth = -3.46 + 0.00229 x weight (g) - 9.48 x 10(-8) x weight (g)(2) + 0.5992 x length (cm) -0.005918 x length(cm)(2) + 0.07808 x correted GA(w). CONCLUSION: The quadratic prediction model showed good internal performance and reduced bias at anthropometric extremes, offering a standardized approach to optimize FT placement and enhance safety in neonatal care. Prospective external validation is required before clinical implementation. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Lauritsen, Julius V AU - Lauritsen JV AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. FAU - Heiring, Christian AU - Heiring C AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. AD - Copenhagen Academy for Medical Education and Simulation, University of Copenhagen, Copenhagen, Denmark. FAU - Wulff, Line AU - Wulff L AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. FAU - Kappel, Susanne S AU - Kappel SS AUID- ORCID: 0000-0002-2023-298X AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. FAU - Aunsholt, Lise AU - Aunsholt L AUID- ORCID: 0000-0003-0965-429X AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. LA - eng GR - None/ PT - Journal Article DEP - 20261014 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - NEX OT - NICU OT - X-ray OT - enteral feeding EDAT- 2026/10/14 18:14 MHDA- 2026/10/14 18:14 CRDT- 2026/10/14 13:40 PHST- 2026/06/10 00:00 [revised] PHST- 2025/11/05 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/14 18:14 [pubmed] PHST- 2026/10/14 18:14 [medline] PHST- 2026/10/14 13:40 [entrez] AID - 10.1002/jpn3.70608 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Oct 14. doi: 10.1002/jpn3.70608. PMID- 42871714 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 2980-2156 (Electronic) IS - 2980-2156 (Linking) VI - 48 IP - 5 DP - 2026 Sep TI - Limited Public Health Utility of LCT Genotyping for Lactose Intolerance Screening in Adolescents: A Cross-Sectional Study from Turkiye. PG - 505-511 LID - 10.14744/cpr.2026.33422 [doi] AB - OBJECTIVE: Lactose intolerance (LI) is a common cause of gastrointestinal complaints in adolescents and young adults, often leading to unnecessary dietary restrictions and reduced calcium intake. Although lactase non-persistence (LNP) is genetically determined, its clinical expression varies considerably. Genetic variants associated with lactase persistence/non-persistence (LCT/MCM6 locus), particularly rs4988235 and rs3754686, are frequently used in genetic testing; however, their clinical utility remains uncertain, especially in populations with a high prevalence of LNP, such as Turkiye. MATERIALS AND METHODS: In this cross-sectional study, 209 individuals aged 12-25 years were evaluated. Lactose-related symptoms were assessed using a validated questionnaire (a score >/=7 defined symptomatic individuals). Consumption of raw milk and fermented dairy products was recorded using a standardized frequency scale. Genotyping of rs4988235 and rs3754686 was performed using TaqMan real-time PCR. Associations between genotype, symptom status, age at symptom onset, and dietary patterns were statistically analyzed. RESULTS: Among the participants, 116 (55.5%) were symptomatic and 93 (44.5%) were asymptomatic. Symptomatic individuals were significantly older (p<0.001). The genotype distributions of rs4988235 and rs3754686 did not differ between symptomatic and asymptomatic individuals and were not associated with age at symptom onset. Dairy consumption patterns were not associated with symptom severity, although fermented dairy consumption was slightly higher among symptomatic individuals (p=0.046). CONCLUSION: Common LCT/MCM6 variants did not predict clinical LI in this adolescent and young adult population. Therefore, routine genetic testing appears unlikely to provide limited additional value in supporting the diagnosis of lactose intolerance, particularly in populations with a high prevalence of LNP. Symptom-based assessment and functional testing should remain central to diagnosis and management, and, supporting appropriate nutritional guidance and avoiding unnecessary dietary restriction. CI - Copyright (c) Author(s). FAU - Mutlu, Hatice AU - Mutlu H AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. AD - Rare Disease Application and Research Center (NADIR), Ankara University, Ankara, Turkiye. FAU - Eker, Ece AU - Eker E AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Cetinkaya, Fulya AU - Cetinkaya F AD - Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Egin, Yonca AU - Egin Y AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Aydin, Sengul AU - Aydin S AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Vatansever, Goksel AU - Vatansever G AD - Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Guven, Ayse Gul AU - Guven AG AD - Department of Adolescent Health, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Aycan, Zehra AU - Aycan Z AD - Department of Adolescent Health, Ankara University Faculty of Medicine, Ankara, Turkiye. AD - Department of Pediatric Endocrinology, Ankara University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260929 PL - Turkey TA - J Clin Pract Res JT - Journal of clinical practice and research JID - 9919014495706676 PMC - PMC13659205 OTO - NOTNLM OT - Adolescents OT - LCT OT - MCM6 OT - dairy consumption OT - lactose intolerance COIS- The authors have no conflicts of interest to declare. EDAT- 2026/10/14 18:14 MHDA- 2026/10/14 18:15 PMCR- 2026/09/29 CRDT- 2026/10/14 11:20 PHST- 2026/02/25 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/10/14 18:15 [medline] PHST- 2026/10/14 18:14 [pubmed] PHST- 2026/10/14 11:20 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - JCPR-48-505 [pii] AID - 10.14744/cpr.2026.33422 [doi] PST - epublish SO - J Clin Pract Res. 2026 Sep 29;48(5):505-511. doi: 10.14744/cpr.2026.33422. eCollection 2026 Sep. PMID- 42871394 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261015 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Cross-cultural adaptation and initial psychometric evaluation of the fruit and vegetable self-efficacy scales among secondary school adolescents in Selangor, Malaysia. PG - 1920784 LID - 10.3389/fpubh.2026.1920784 [doi] LID - 1920784 AB - Fruit and vegetable self-efficacy may influence adolescent dietary behavior, yet culturally adapted measures for Malaysian adolescents remain limited. This study aimed to cross-culturally adapt the 17-item Fruit Self-Efficacy (FSE) and Vegetable Self-Efficacy (VSE) scales into Malay and obtain initial evidence on their measurement properties. The study comprised two sequential phases. Phase 1 involved forward and backward translation, cognitive debriefing with five adolescents, linguistic equivalence assessment by six experts, content validity assessment by nine experts, qualitative and quantitative face validity assessment involving 15 unique adolescents, and pretesting with 37 adolescents. Phase 2 comprised an initial psychometric evaluation among 128 adolescents from four classes in one purposively selected public secondary school in Selangor. The adaptation process included age-appropriate refinements to the linguistic and contextual aspects of fruit and vegetable preparation, snacks, social occasions, serving terminology, and meal contexts. In particular, "pieces of fruit" was adapted to "servings of fruit" and supported by a pictorial serving guide, while "hot meal" was contextualized as "main meal." All source items met the prespecified content-validity criteria. Scale-level content-validity indices were 0.99 for FSE and 0.95 for VSE, while scale-level face-validity indices ranged from 0.95 to 0.97. One FSE item with an initial clarity index below the criterion was revised using concrete preparation examples and reassessed. In the separate psychometric sample, the prespecified one-factor FSE model showed acceptable fit (CFI = 0.974, TLI = 0.970, RMSEA = 0.069, SRMR = 0.061), although pronounced item-level ceiling effects were observed. The prespecified VSE model showed substantial misfit (RMSEA = 0.136, SRMR = 0.099), and its structural validity was not established. A same-sample post hoc specification with six correlated residuals remained hypothesis-generating because its RMSEA was 0.094. The multistage process produced linguistically and culturally adapted FSE and VSE scales that met the prespecified content and face-validity criteria among the expert and adolescent samples assessed. However, evidence supporting the one-factor structure was stronger for FSE than VSE. Further cognitive investigation and adequately powered, independent multisite evaluation across diverse ethnic and age groups are required before broader use. CI - Copyright (c) 2026 Zaini, Jabir, Mat Ludin, Abd Talib and Ishak. FAU - Zaini, Zanariah AU - Zaini Z AD - Centre for Toxicology and Health Risk, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. AD - Institute for Health Behavioural Research, National Institutes of Health, Ministry of Health, Shah Alam, Malaysia. FAU - Jabir, Nursyazwani AU - Jabir N AD - Institute for Health Behavioural Research, National Institutes of Health, Ministry of Health, Shah Alam, Malaysia. FAU - Mat Ludin, Arimi Fitri AU - Mat Ludin AF AD - Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Abd Talib, Ruzita AU - Abd Talib R AD - Centre for Community Health Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Ishak, Ismarulyusda AU - Ishak I AD - Centre for Toxicology and Health Risk, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Malaysia MH - Psychometrics MH - *Fruit MH - *Self Efficacy MH - *Vegetables MH - Adolescent MH - Female MH - *Cross-Cultural Comparison MH - Male MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Schools PMC - PMC13658580 OTO - NOTNLM OT - adolescents OT - cross-cultural adaptation OT - fruit and vegetable intake OT - questionnaire adaptation OT - self-efficacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 09:51 PHST- 2026/06/26 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 09:51 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1920784 [doi] PST - epublish SO - Front Public Health. 2026 Sep 29;14:1920784. doi: 10.3389/fpubh.2026.1920784. eCollection 2026. PMID- 42871234 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 18 DP - 2026 TI - Advanced Maternal Age and Risk of Large-for-Gestational-Age Infants: Mediating Roles of Prenatal Body Mass Index and Specific Lipid Profiles. PG - 642291 LID - 10.2147/IJWH.S642291 [doi] LID - 642291 AB - BACKGROUND: Advanced maternal age (AMA) is associated with adverse pregnancy outcomes, but the mechanisms linking AMA to fetal overgrowth remain poorly quantified. This retrospective cohort study aimed to estimate the potential statistical mediating roles of prenatal BMI and blood lipids in the association between AMA and large-for-gestational-age (LGA) infants. METHODS: In this retrospective cohort study, 11,504 singleton pregnancies (28-41 weeks) in Changzhou, China, were analyzed. Women were classified as AMA (>/=35 years, n=1,330) or non‑AMA (n=10,174). Multivariable regression and mediation analyses assessed associations between AMA, lipid profiles, BMI, and LGA risk. RESULTS: AMA pregnancies showed significantly higher LGA rates than non-AMA pregnancies (24.44% vs 14.37%, P<0.001). After adjustment, AMA independently increased LGA risk (adjusted OR: 1.37, 95% CI: 1.18-1.60, P<0.001). AMA was associated with higher prenatal BMI (beta=0.37 kg/m(2)), elevated triglycerides (beta=0.27 mmol/L), and lower low density lipoprotein-cholesterol (LDL-C) (beta=-0.07 mmol/L) (all P<0.001). These metabolic factors independently predicted LGA risk: BMI (adjusted OR: 1.20 per 1 kg/m(2) increase), triglycerides (adjusted OR: 1.13 per 1 mmol/L increase), and LDL-C (adjusted OR: 1.32 per 1 mmol/L decrease) (all P<0.001). Exploratory mediation analysis estimated that prenatal BMI statistically accounted for 19.8% of the total AMA‑LGA effect, while triglycerides and LDL‑C accounted for 5.1% and 2.8%, respectively. CONCLUSION: AMA is independently associated with increased LGA risk, and this association is statistically partially mediated by higher BMI, elevated triglycerides, and lower LDL‑C. Given the retrospective observational design and the single‑timepoint measurement of lipids at delivery, these findings should be interpreted as statistical decompositions of associations rather than as causal. Nevertheless, they suggest that BMI and lipid profiles may be useful for risk stratification in older pregnant women, though prospective validation is warranted. CI - (c) 2026 Zhang et al. FAU - Zhang, Bin AU - Zhang B AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. FAU - Yan, Qi AU - Yan Q AD - Department of Obstetrics and Gynecology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China. FAU - Zhan, Zhaolong AU - Zhan Z AUID- ORCID: 0009-0005-6012-0658 AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. FAU - Chen, Xusheng AU - Chen X AUID- ORCID: 0009-0003-5032-8709 AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. FAU - Yuan, Xiaosong AU - Yuan X AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. LA - eng PT - Journal Article DEP - 20261008 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC13658422 OTO - NOTNLM OT - advanced maternal age OT - body mass index OT - large for gestational age OT - lipid profiles OT - mediation analysis COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/10/08 CRDT- 2026/10/14 08:43 PHST- 2026/07/29 00:00 [received] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 08:43 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 642291 [pii] AID - 10.2147/IJWH.S642291 [doi] PST - epublish SO - Int J Womens Health. 2026 Oct 8;18:642291. doi: 10.2147/IJWH.S642291. eCollection 2026. PMID- 42871191 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261015 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Initial screening positivity for suspected scoliosis and machine learning-assisted risk prioritization: a school-based cross-sectional study in Wuhai, Inner Mongolia, China. PG - 1923480 LID - 10.3389/fpubh.2026.1923480 [doi] LID - 1923480 AB - BACKGROUND: Questionnaire-based prescreening is inexpensive, but its ability to identify students with abnormal scoliosis screening findings is uncertain. We assessed whether questionnaire variables improved prediction beyond a demographic and anthropometric baseline and whether simple on-site physical signs could further improve risk prioritization. The outcome was initial screening positivity, defined by a positive Adams forward-bend test together with an angle of trunk rotation (ATR) of >/=5 degrees . METHODS: This school-based cross-sectional study included 3,559 students aged 10-18 years from four schools in Wuhai, Inner Mongolia, China. Participants underwent anthropometry, postural examination, the Adams test, electronic ATR measurement after a visually positive Adams test, and a structured questionnaire. Questionnaire models were assessed first. As questionnaire variables did not improve the demographic and anthropometric baseline, the final models used age, sex, grade, BMI, shoulder asymmetry, and foot arch morphology. Logistic regression, random forest, and XGBoost were evaluated with five-fold stratified cross-validation repeated three times. RESULTS: Of 3,559 students, 392 (11.01%) met the initial screening-positive definition. Among models without physical signs, the demographic and anthropometric baseline model performed best (ROC-AUC, 0.633; PR-AUC, 0.163), while adding all or selected questionnaire variables did not improve performance. Among physical-sign models, random forest had the highest ROC-AUC (0.787) and PR-AUC (0.400), and the lowest Brier score (0.082), although its ROC-AUC gain over logistic regression was modest (0.014; 95% CI, -0.001 to 0.029). Prioritizing the top 30% by risk identified 258 of 392 positive results (65.8%); approximately 60.4% of students required prioritization to achieve 90% sensitivity. CONCLUSION: Questionnaire information did not support individual prescreening. Simple physical signs improved internal risk ranking for initial screening positivity, but the model cannot replace the combined screening procedure or diagnosis. External validation against clinical and radiographic reference standards is needed. CI - Copyright (c) 2026 Wang, Liu, Wang, Duan, Zhang, Li, Yan and Hai. FAU - Wang, Hongyan AU - Wang H AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Liu, Xiafei AU - Liu X AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Wang, Biao AU - Wang B AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Duan, Lijuan AU - Duan L AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Zhang, Xia AU - Zhang X AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Li, Ying AU - Li Y AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Yan, Cuitao AU - Yan C AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Hai, Donghu AU - Hai D AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - China/epidemiology MH - *Scoliosis/diagnosis/epidemiology MH - Child MH - Female MH - *Machine Learning MH - Male MH - Adolescent MH - Surveys and Questionnaires MH - *Mass Screening/methods MH - Risk Assessment MH - Schools PMC - PMC13658430 OTO - NOTNLM OT - adolescents OT - children OT - machine learning OT - risk prioritization OT - school health OT - scoliosis screening COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 08:27 PHST- 2026/06/30 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 08:27 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1923480 [doi] PST - epublish SO - Front Public Health. 2026 Sep 29;14:1923480. doi: 10.3389/fpubh.2026.1923480. eCollection 2026. PMID- 42870901 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Negative school gossip, self-esteem, and exercise intention among Chinese adolescents: a mediation model. PG - 1923752 LID - 10.3389/fpsyg.2026.1923752 [doi] LID - 1923752 AB - PURPOSE: This study examined the associations among negative school gossip, self-esteem, and general exercise intention among Chinese adolescents, with particular attention to the mediating role of self-esteem and the relevance of these associations to physical education (PE) and school-based movement contexts. METHODS: A cross-sectional online questionnaire survey was conducted among 1,713 junior middle school students in China. Negative school gossip, self-esteem, and exercise intention were assessed using established self-report scales. Data were analyzed using latent-variable structural equation modeling in Mplus 8.3. Common method bias, reliability, convergent validity, discriminant validity, and model fit were examined before testing the mediation model. Bias-corrected bootstrap analysis with 2,000 bootstrap samples was used to test the indirect association. A sensitivity analysis was conducted by controlling for gender, grade, region, parental education, only-child status, and family economic status. RESULTS: The three-factor measurement model showed better fit than alternative measurement models, and the measures demonstrated acceptable reliability and validity. In the main structural model, negative school gossip was negatively associated with self-esteem (beta = -0.157, p < 0.001) and exercise intention (beta = -0.063, p = 0.031), while self-esteem was positively associated with exercise intention (beta = 0.240, p < 0.001). The standardized indirect association from negative school gossip to exercise intention through self-esteem was significant [beta = -0.038, 95% bootstrap CI (-0.055, -0.024)], accounting for 37.62% of the total association. The pattern remained stable after controlling for demographic covariates. CONCLUSION: Negative school gossip was associated with weaker general exercise intention among Chinese adolescents, and self-esteem partly accounted for this association. Although exercise intention was not measured specifically for PE lessons, the findings are relevant to PE because school movement contexts are highly visible and peer-evaluative settings in which reputation-based exclusion and stigma may reduce psychological safety. The results therefore suggest that supportive peer climates and protection from gossip-related exclusion may be important for inclusive PE and equitable participation in school-based physical activity. CI - Copyright (c) 2026 Ma and Chen. FAU - Ma, Jiaxin AU - Ma J AD - School of Humanities and Arts, Deyang College of Urban Rail Transit, Deyang, Sichuan, China. FAU - Chen, Xingtong AU - Chen X AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13657928 OTO - NOTNLM OT - Chinese adolescents OT - exercise intention OT - mediation OT - negative school gossip OT - self-esteem OT - structural equation modeling COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 05:35 PHST- 2026/06/30 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 05:35 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1923752 [doi] PST - epublish SO - Front Psychol. 2026 Sep 29;17:1923752. doi: 10.3389/fpsyg.2026.1923752. eCollection 2026. PMID- 42870848 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Construction and empirical testing of a verifiable food safety complaint risk-triage model using human foods complaint system data from the United States Food and Drug Administration. PG - 1919174 LID - 10.3389/fnut.2026.1919174 [doi] LID - 1919174 AB - BACKGROUND: Food safety complaint systems contain large numbers of heterogeneous adverse-event reports, but surveillance use requires reproducible data sources and interpretable rules for ranking reports that may involve severe outcomes. OBJECTIVE: To construct and test a transparent case-level logistic triage model that assigns FDA Human Foods Complaint System (HFCS) reports an urgent-priority score for earlier human review. METHODS: The official HFCS quarterly workbook was downloaded from the FDA website on 2026-05-13, and case-based reports received from January 1, 2004 through December 31, 2025 were analyzed (n = 149,642). Predictors were derived from validated age and date fields, sex, suspected product descriptors, MedDRA preferred-term counts, symptom-domain indicators, report year, and event-to-receipt lag. Product-group proportions were summarized with unadjusted Wilson 95% confidence intervals and interpreted descriptively. A balanced logistic regression model was assessed on a stratified test set. RESULTS: Urgent-priority outcomes occurred in 47,093 reports (31.47%). Death appeared in 17,005 reports and hospitalization in 23,405. The hospitalization proportion was 24.9% (95% CI, 24.5-25.3%) among dietary-supplement reports and 18.2% (16.3-20.3%) among infant/baby-food reports; these unadjusted proportions were not interpreted as population risk differences. The model achieved an AUC of 0.723, PR-AUC of 0.526, Brier score of 0.214, Brier skill score of 0.008, a calibration intercept of -0.03, and a calibration slope of 0.91 on 37,411 test cases. Symptom count and the infant/baby-food indicator had the largest positive model weights. CONCLUSION: HFCS data can support reproducible complaint triage. The model is suitable for ordering reports for human review, whereas product-group contrasts and raw predicted probabilities require cautious interpretation and temporal or external validation. CI - Copyright (c) 2026 Chen. FAU - Chen, Jinming AU - Chen J AD - College of Food Science and Engineering, Shanxi Agricultural University, Taigu, Shanxi, China. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13657942 OTO - NOTNLM OT - United States Food and Drug Administration OT - adverse events OT - complaint triage OT - food safety OT - machine learning OT - reproducibility of results COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 05:19 PHST- 2026/06/25 00:00 [received] PHST- 2026/08/20 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 05:19 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fnut.2026.1919174 [doi] PST - epublish SO - Front Nutr. 2026 Sep 29;13:1919174. doi: 10.3389/fnut.2026.1919174. eCollection 2026. PMID- 42870691 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261016 IS - 1467-7687 (Electronic) IS - 1363-755X (Print) IS - 1363-755X (Linking) VI - 29 IP - 6 DP - 2026 Nov TI - Exploring a Range of Potential Factors Promoting and Constraining EF in South African Preschoolers. PG - e70289 LID - 10.1111/desc.70289 [doi] LID - e70289 AB - BACKGROUND: Socioeconomic disadvantage is widely associated with poorer cognitive and educational outcomes. However, emerging evidence suggests that children in low-income contexts may demonstrate resilience in executive function (EF) development. This study examined the predictors of EF in South African preschoolers from disadvantaged communities to identify modifiable, context-specific influences. METHODS: 125 Children (aged 3-5 years) and their caregivers were recruited from 15 early childhood centers in Cape Town. Children completed three tablet-based EF tasks from the Early Years Toolbox measuring working memory, inhibition, shifting, while caregivers reported on demographic variables, household assets, child sleep, child screen time, child exposure to violence, and parenting practices. Multiple linear regressions examined predictors of child EF, with exploratory analyses on a subset (n = 22) for hair cortisol analysis. RESULTS: Older child age (beta = 0.37, p < 0.001), caregiver secondary education (beta = 0.22, p = 0.003), and fewer sleep difficulties (beta = -0.45, p = 0.042) significantly predicted higher child EF scores, together explaining 25% of variance. Household assets, screen time, violence exposure, and parenting scores were non-significant. In the subsample, hair cortisol concentration correlated positively with EF (rho = 0.55, p = 0.009), suggesting potential adaptive calibration under adversity. CONCLUSIONS: Findings highlight that modifiable proximal factors (e.g., caregiver education and child sleep) shape EF development more strongly than socioeconomic indicators. Results challenge the presumed universality of SES-EF gradients and underscore the importance of culturally grounded, contextually validated measures for understanding resilience and early cognitive development in Majority World settings. CI - (c) 2026 The Author(s). Developmental Science published by John Wiley & Sons Ltd. FAU - Beukes, Johanna AU - Beukes J AUID- ORCID: 0000-0003-2644-7081 AD - SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Cook, Caylee AU - Cook C AD - SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Howard, Steven J AU - Howard SJ AUID- ORCID: 0000-0002-1258-3210 AD - Early Start and School of Education, University of Wollongong, Wollongong, NSW, Australia. FAU - Scerif, Gaia AU - Scerif G AUID- ORCID: 0000-0002-6371-8875 AD - Department of Experimental Psychology, University of Oxford, Oxford, UK. FAU - Sharpley, Christopher F AU - Sharpley CF AUID- ORCID: 0000-0001-7922-4848 AD - Department of Neuroscience, University of New England, Armidale, NSW, Australia. FAU - Hart, Robert AU - Hart R AD - Department of Biomedical Sciences, University of New England, Armidale, NSW, Australia. FAU - Draper, Catherine AU - Draper C AUID- ORCID: 0000-0002-2885-437X AD - SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. LA - eng GR - University of Wollongong/ GR - DSI-NRF Centre of Excellence in Human Development, University of the Witwatersrand, Johannesburg/ GR - University of Wollogong/ PT - Journal Article PL - England TA - Dev Sci JT - Developmental science JID - 9814574 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Humans MH - Child, Preschool MH - Female MH - South Africa MH - Male MH - *Executive Function/physiology MH - Hydrocortisone/metabolism/analysis MH - *Child Development/physiology MH - Parenting MH - Memory, Short-Term/physiology MH - Hair/chemistry MH - Cognition/physiology MH - Socioeconomic Factors MH - Poverty MH - Sleep/physiology PMC - PMC13662612 OTO - NOTNLM OT - South Africa OT - executive function OT - preschool OT - socioeconomic status COIS- There is no conflict of interest in this project. EDAT- 2026/10/14 05:34 MHDA- 2026/10/14 05:35 PMCR- 2026/10/14 CRDT- 2026/10/14 04:04 PHST- 2026/08/26 00:00 [revised] PHST- 2025/10/30 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/10/14 05:35 [medline] PHST- 2026/10/14 05:34 [pubmed] PHST- 2026/10/14 04:04 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - DESC70289 [pii] AID - 10.1111/desc.70289 [doi] PST - ppublish SO - Dev Sci. 2026 Nov;29(6):e70289. doi: 10.1111/desc.70289. PMID- 42870588 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261016 IS - 2473-4209 (Electronic) IS - 0094-2405 (Linking) VI - 53 IP - 10 DP - 2026 Oct TI - Quantitative and qualitative magnetic resonance imaging-based analysis to predict postoperative disease progression in hepatocellular carcinoma. PG - e70692 LID - 10.1002/mp.70692 [doi] AB - BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common abdominal malignancies and the third leading cause of cancer-related death globally. Predicting the postoperative prognosis of HCC remains an important area of clinical research. Many qualitative magnetic resonance imaging (MRI) indicators have been used for noninvasive and global assessment of HCC for diagnostic and prognostic purposes. However, the prognostic value of quantitative MRI parameters has not been extensively validated in multicenter cohorts. OBJECTIVE: This study aimed to verify whether MRI-based imaging features could improve prognostic prediction in patients with HCC. We developed prognostic models to predict the progression-free survival (PFS) of patients with HCC. METHODS: In this multicenter cohort study, 203 patients diagnosed with early- to intermediate-stage HCC were divided into a training dataset and an external validation dataset. In addition to clinical indicators, the candidates included qualitative and quantitative MRI data. Three noninvasive models were developed: the Clinical Model, the Radiological Model, and the Combined Model. The patients were stratified according to the risk of disease progression. Model performance was assessed through discrimination and calibration analyses, decision curve analysis was performed, and a clinical application was designed. In addition, the subgroups at different stages of the disease were analyzed, and PFS was compared between the high- and low-risk groups. RESULTS: Prognostic nutritional index, tumor-feeding vessels, mosaic architecture and the signal enhancement ratio (SER) parameter were identified as independent predictors of disease progression in patients with HCC. The Combined Model demonstrated superior performance compared with the Clinical and Radiological Models. The areas under the curve (AUCs) in the training dataset were 0.822, 0.748, and 0.795, whereas those in the validation dataset were 0.819, 0.758, and 0.677, respectively. The Combined Model also demonstrated favorable calibration and greater net clinical benefit on decision curve analysis. Its predictive ability remained consistent regardless of the Child-Pugh classification or Barcelona Clinic Liver Cancer stage. CONCLUSION: This study highlights the important role of quantitative and qualitative MRI assessments in evaluating the prognosis of patients with HCC and emphasizes the predictive value of SER parameter. However, these findings should nevertheless be interpreted with caution given the relatively limited sample size, despite the use of bootstrap internal validation and external validation. CI - (c) 2026 American Association of Physicists in Medicine. FAU - Wang, He AU - Wang H AD - Department of Radiology, Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. FAU - Yin, Minggang AU - Yin M AD - School of Public Health, Southern Medical University, Guangzhou, China. FAU - Chen, Zhiyan AU - Chen Z AD - Department of Radiology, Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. FAU - Zou, Feixiang AU - Zou F AD - Department of Radiology, Wuchuan Gelao and Miao Autonomous County People's Hospital, Zunyi, China. FAU - Chen, Yuan AU - Chen Y AD - Department of Interventional Treatment, Zhongshan City People's Hospital, Zhongshan, China. FAU - An, Taixue AU - An T AD - Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. FAU - Li, Qiyang AU - Li Q AD - Department of Radiology, Shenzhen People's Hospital, Shenzhen, China. FAU - Cai, Mingyue AU - Cai M AD - Department of Minimally Invasive Interventional Radiology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - Fu, Siri AU - Fu S AD - Zhuhai Interventional Medical Centre, Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. AD - Zhuhai Engineering Technology Research Center of Intelligent Medical Imaging, Zhuhai People's Hospital , The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. FAU - Yu, Xiangrong AU - Yu X AD - Department of Radiology, Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. LA - eng GR - 82071915/National Natural Science Foundation of China/ GR - 2023A1515011384/Guangdong Basic and Applied Basic Research Foundation/ GR - 202201020570/Science and Technology Planning Project of Guangzhou/ GR - 2023LCTS-07/The Clinical Research Promotion Project of Zhuhai People's Hospital/ PT - Journal Article PT - Multicenter Study PT - Validation Study PL - United States TA - Med Phys JT - Medical physics JID - 0425746 SB - IM MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Carcinoma, Hepatocellular/surgery/diagnostic imaging/pathology MH - *Disease Progression MH - Image Processing, Computer-Assisted MH - *Liver Neoplasms/surgery/diagnostic imaging/pathology MH - *Magnetic Resonance Imaging MH - Postoperative Period MH - Prognosis OTO - NOTNLM OT - hepatocellular carcinoma OT - magnetic resonance imaging OT - prognosis OT - progression-free survival EDAT- 2026/10/14 05:33 MHDA- 2026/10/14 05:34 CRDT- 2026/10/14 03:34 PHST- 2026/07/14 00:00 [revised] PHST- 2025/04/01 00:00 [received] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/10/14 05:34 [medline] PHST- 2026/10/14 05:33 [pubmed] PHST- 2026/10/14 03:34 [entrez] AID - 10.1002/mp.70692 [doi] PST - ppublish SO - Med Phys. 2026 Oct;53(10):e70692. doi: 10.1002/mp.70692. PMID- 42870359 OWN - NLM STAT- Publisher LR - 20261014 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) DP - 2026 Oct 13 TI - Medical Student Meal Support for Patients With Eating Disorders. LID - 10.1002/eat.70241 [doi] AB - OBJECTIVE: Patients hospitalized for eating disorders (EDs) often experience distress during supervised meals, and medical trainees frequently report limited comfort caring for this population. We developed Meal Partners, a mealtime support initiative designed to support hospitalized pediatric patients with EDs while improving trainee confidence. The purpose of this study was to evaluate the feasibility and acceptability of this medical-student-led service. METHOD: Meal Partners was implemented at a tertiary pediatric hospital in collaboration with the Eating Disorder Interdisciplinary Team. Medical student volunteers completed structured training on inpatient ED care, mealtime support, and communication strategies. Hospitalized patients undergoing nutritional rehabilitation were referred for meal support. Patient, caregiver, and volunteer surveys assessed perceptions of the program, while meal completion percentages were compared between meals with and without volunteer support. Pre- and post-volunteering surveys evaluated volunteer comfort and understanding of ED care. RESULTS: Six hospitalized patients assented to participate, with four ultimately receiving meal support. Thirty-two medical students completed training, and post-volunteering surveys demonstrated increased comfort interacting with patients with EDs, improved understanding of the inpatient experience, and reduced uncertainty in these interactions. All volunteers reported that the experience would benefit their future clinical practice. DISCUSSION: Meal Partners demonstrates the feasibility and acceptability of a medical student-led mealtime support initiative for patients hospitalized with EDs. Preliminary findings suggest benefits for medical education supporting further expansion and evaluation of this low-cost intervention. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Suresh, Sriyaa AU - Suresh S AUID- ORCID: 0009-0001-5150-0545 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Singh, Shivani AU - Singh S AUID- ORCID: 0009-0009-3426-119X AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - English, Sadie AU - English S AUID- ORCID: 0009-0007-9345-7235 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Taylor, Julia AU - Taylor J AUID- ORCID: 0000-0002-3661-1773 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Boguszewski, Katherine AU - Boguszewski K AUID- ORCID: 0000-0002-9575-9428 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Manthe, Eva AU - Manthe E AUID- ORCID: 0009-0001-5180-5170 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Esselstyn, June AU - Esselstyn J AUID- ORCID: 0009-0006-7123-5984 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Stephens, Sara Groff AU - Stephens SG AUID- ORCID: 0000-0002-7416-3756 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. LA - eng GR - Department of Pediatrics, School of Medicine, University of Virginia/ PT - Journal Article DEP - 20261013 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM OTO - NOTNLM OT - adolescent medicine OT - eating disorders OT - inpatient care OT - supportive interventions OT - volunteer EDAT- 2026/10/14 05:33 MHDA- 2026/10/14 05:33 CRDT- 2026/10/14 00:39 PHST- 2026/10/05 00:00 [revised] PHST- 2026/06/08 00:00 [received] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/14 05:33 [medline] PHST- 2026/10/14 05:33 [pubmed] PHST- 2026/10/14 00:39 [entrez] AID - 10.1002/eat.70241 [doi] PST - aheadofprint SO - Int J Eat Disord. 2026 Oct 13. doi: 10.1002/eat.70241. PMID- 42870043 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261016 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 13 TI - Exercise management in pediatric type 1 diabetes: a multicenter study of healthcare professionals' perspectives. LID - 10.1007/s00431-026-07472-7 [doi] LID - 842 AB - Regular exercise is an important component of care for children with type 1 diabetes (T1D), supporting both physical and psychological health. However, many do not meet recommended activity levels, and exercise does not consistently improve glycemic control. Exercise management in T1D is complex and influenced by multiple factors, including child, activity, and treatment characteristics. These challenges highlight the importance of comprehensive exercise-directed guidance (EDG). This study aimed to characterize EDG practices in pediatric T1D and identify key challenges faced by healthcare professionals (HCPs). Physicians, nurses, and dietitians from 11 pediatric diabetes centers participated. Participants completed anonymized electronic questionnaires assessing current practices, content, and perceived challenges related to EDG. Response rate was 87.2%; 130 HCPs participated; all reported providing EDG to patients. Considerable variability was observed in the timing, content, and educational resources used. While the majority (85.9%) reported offering guidance to all patients, others indicated guiding only when specific needs arose. The most frequently addressed topics included the immediate effects on blood glucose, adjusting carbohydrate intake, and general preparations for exercise. Less frequently discussed topics were planning exercise regimens and encouraging involvement of family or peers. Challenges by order of prevalence were insufficient teaching aids (42.3%), EDG complexity (40.0%), visit duration (36.2%), and knowledge gaps (33.1%). CONCLUSION: Although HCPs acknowledge the importance of exercise in pediatric T1D and incorporate EDG into clinical care, substantial variability exists in its delivery. Improving the availability and usability of educational tools and strengthening social support components may enhance exercise education for children with T1D. WHAT IS KNOWN: * Exercise-directed guidance (EDG) is essential for children with type-1-diabetes, yet challenging to implement. * Knowledge of barriers to EDG is growing, but evidence remains limited across healthcare settings and professional groups. WHAT IS NEW: * In this national multicenter study of healthcare professionals, all participants reported providing EDG, yet its timing,content, and availability of educational tools varied. * Limited teaching aids, the complexity of EDG, and time constraints were the main barriers; addressing family and peer involvement and exercise-specific planning were identified as areas for improvement. CI - (c) 2026. The Author(s). FAU - Reznik, Hilla AU - Reznik H AD - The Ruth & Bruce Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel. FAU - Brener, Avivit AU - Brener A AD - The Institute of Pediatric Endocrinology, Diabetes, and Metabolism, Dana Dwek Children's Hospital, Ichilov Hospital, Tel Aviv, Israel. AD - School of Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Sharkia, Mohamad AU - Sharkia M AD - The Ruth & Bruce Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel. AD - Pediatric Endocrinology and Diabetes Unit, HaEmek Medical Center, Afula, Israel. FAU - Rachmiel, Marianna AU - Rachmiel M AD - Pediatric Endocrinology and Diabetes Institute, Shamir (Assaf Harofeh) Medical Center, Beer Yakov, Israel. AD - School of Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Yeshayahu, Yonatan AU - Yeshayahu Y AD - Department of Pediatrics, Samson Assuta Ashdod University Hospital, Ashdod, Israel. AD - Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. FAU - Zalmon-Koren, Ilana AU - Zalmon-Koren I AD - The Ruth & Bruce Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel. AD - Pediatric Endocrinology Unit, Lady Davis Carmel Medical Center, Clalit Health Services, Haifa, Israel. FAU - Carmon, Lior AU - Carmon L AD - Pediatric Endocrinology Unit, Soroka Medical Center, Beer-Sheva, Israel. AD - Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. FAU - Pivko-Levy, Dikla AU - Pivko-Levy D AD - Pediatric Endocrine and Diabetes Unit, E. Wolfson Medical Center, Holon, Israel. FAU - Mouler, Marie AU - Mouler M AD - The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, 4920235, Petach Tikva, Israel. AD - School of Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - de Vries, Liat AU - de Vries L AD - The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, 4920235, Petach Tikva, Israel. AD - School of Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Pinhas-Hamiel, Orit AU - Pinhas-Hamiel O AD - Pediatric Endocrine and Diabetes Division, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Ramat Gan, Israel. AD - School of Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Levy-Khademi, Floris AU - Levy-Khademi F AD - Division of Pediatric Endocrinology, Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel. AD - The Faculty of Medicine, Hebrew University, Jerusalem, Israel. FAU - Cohen, Michal AU - Cohen M AUID- ORCID: 0000-0003-4209-7624 AD - The Ruth & Bruce Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel. michalcohen@technion.ac.il. AD - Pediatric Endocrinology and Diabetes Unit, The Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel. michalcohen@technion.ac.il. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20261013 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/therapy MH - Child MH - Female MH - Male MH - Surveys and Questionnaires MH - *Attitude of Health Personnel MH - *Exercise Therapy/methods MH - Adolescent MH - *Exercise MH - Patient Education as Topic PMC - PMC13661701 OTO - NOTNLM OT - Barriers OT - Education OT - Exercise OT - Pediatrics OT - Type 1 diabetes COIS- Declarations. Ethics approval and consent to participate: The study was approved by the institutional Helsinki committees of all participating centers. Names of the approval committees: Helsinki Committee Rambam Health Care Campus, Internal Review Board Tel Aviv Sourasky Medical Center, Helsinki Committee Emek Medical Center, Helsinki Committee Shamir Medical Center, Internal Review Board Assuta Hospital, Helsinki Committee Lin Medical Center, Helsinki Committee Soroka Medical Center, Helsinki Committee Wolfson Medical Center, Helsinki Committee Schneider Children's Medical Center of Israel, Helsinki Committee Sheba Medical Center, Helsinki Committee Shaarei Zedek Medical Center. Informed consent to participate was obtained from participants prior to study enrollment. Research was conducted in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Conflict of interest: The authors declare no competing interests. EDAT- 2026/10/14 05:34 MHDA- 2026/10/14 05:35 PMCR- 2026/10/13 CRDT- 2026/10/13 23:46 PHST- 2026/05/08 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/09/17 00:00 [revised] PHST- 2026/10/14 05:35 [medline] PHST- 2026/10/14 05:34 [pubmed] PHST- 2026/10/13 23:46 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - 10.1007/s00431-026-07472-7 [pii] AID - 7472 [pii] AID - 10.1007/s00431-026-07472-7 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 13;185(11):842. doi: 10.1007/s00431-026-07472-7. PMID- 42869922 OWN - NLM STAT- Publisher LR - 20261013 IS - 1348-4214 (Electronic) IS - 0916-9636 (Linking) DP - 2026 Oct 13 TI - Association between the triglyceride-glucose index and arterial stiffness in adolescents: the Wakayama study. LID - 10.1038/s41440-026-02837-9 [doi] AB - Insulin resistance plays an important role in early vascular dysfunction during adolescence. The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. This study aimed to examine the association between the TyG index and arterial stiffness in adolescents. This cross-sectional study included 617 adolescents aged 15-18 years in a school-based setting. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV) using an automated oscillometric device with appropriately sized cuffs. Blood samples were collected after an overnight fast to calculate the TyG index and the homeostasis model assessment of insulin resistance (HOMA-IR). When participants were categorized into tertiles of the TyG index, baPWV increased significantly across tertiles. This association was observed in both obese and non-obese participants. In multivariable linear regression models adjusting for age, sex, systolic blood pressure, BMI z-score, heart rate, HDL cholesterol, HbA1c, and serum uric acid, the TyG index remained independently associated with baPWV; however, this association was attenuated after further adjustment for HOMA-IR. Receiver operating characteristic curve analysis showed that the area under the curve for the TyG index was comparable to that for HOMA-IR in identifying elevated baPWV. These results suggest that the TyG index was significantly associated with arterial stiffness in adolescents, regardless of obesity status. Although its predictive performance was similar to that of HOMA-IR, the TyG index may serve as a practical marker of early vascular alterations in this population. CI - (c) 2026. The Author(s), under exclusive licence to The Japanese Society of Hypertension. FAU - Miyai, Nobuyuki AU - Miyai N AUID- ORCID: 0000-0002-7208-4405 AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. miyain@wakayama-med.ac.jp. FAU - Zhang, Yan AU - Zhang Y AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. FAU - Sougawa, Yukiko AU - Sougawa Y AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. FAU - Hayakawa, Hiroko AU - Hayakawa H AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. FAU - Tsuji, Kumiko AU - Tsuji K AD - Wakayama Faculty of Nursing, Tokyo Healthcare University, Wakayama, Japan. FAU - Terada, Kazufumi AU - Terada K AD - Faculty of Physical Education, Tenri University, Nara, Japan. FAU - Utsumi, Miyoko AU - Utsumi M AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. FAU - Arita, Mikio AU - Arita M AD - Sumiya Rehabilitation Hospital, Wakayama, Japan. LA - eng PT - Journal Article DEP - 20261013 PL - England TA - Hypertens Res JT - Hypertension research : official journal of the Japanese Society of Hypertension JID - 9307690 SB - IM OTO - NOTNLM OT - Adolescents OT - Arterial stiffness OT - Cardiovascular risk OT - Insulin resistance OT - TyG index COIS- Compliance with ethical standards. Conflict of interest: The authors declare no potential conflicts of interest with respect to the research, authorship, or publication of this article. Ethical approval: This study was conducted in accordance with the principles of the Declaration of Helsinki and its later amendments or comparable ethical standards. This study was approved by the Ethics Committee of the Wakayama Medical University (approval no. 596). Informed consent: Written informed consent for the use of health examination data for research purposes was obtained from all participants and their guardians, as appropriate, following explanation of the study aims and procedures. EDAT- 2026/10/14 05:33 MHDA- 2026/10/14 05:33 CRDT- 2026/10/13 23:31 PHST- 2026/08/11 00:00 [received] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/09/08 00:00 [revised] PHST- 2026/10/14 05:33 [medline] PHST- 2026/10/14 05:33 [pubmed] PHST- 2026/10/13 23:31 [entrez] AID - 10.1038/s41440-026-02837-9 [pii] AID - 10.1038/s41440-026-02837-9 [doi] PST - aheadofprint SO - Hypertens Res. 2026 Oct 13. doi: 10.1038/s41440-026-02837-9. PMID- 42869441 OWN - NLM STAT- Publisher LR - 20261013 IS - 1527-330X (Electronic) IS - 1090-820X (Linking) DP - 2026 Oct 14 TI - Development and Validation of Two skin Quality Photonumeric Scales Assessing Skin Smoothness and Cheek Lines. LID - sjag217 [pii] LID - 10.1093/asj/sjag217 [doi] AB - BACKGROUND: Skin smoothness and cheek lines are key indicators of skin quality targeted by aesthetic treatments and surgery to improve perceived youthfulness and confidence. Validated photonumeric scales provide a standardized, reliable, and reproducible grading of skin quality. OBJECTIVES: To develop and validate two Canfield skin quality photonumeric scales assessing skin smoothness and cheek lines. METHODS: Two 5-level photonumeric scales for skin smoothness and cheek lines were developed. Validation consisted of three exercises: live validation, clinical relevance, and photographic validation. Five certified clinicians completing the grading in two sessions, two weeks apart and agreement was measured using Cicchetti-Allison kappa. Sixty-eight and 72 participants, respectively, attended validation for skin smoothness and cheek lines. Clinical relevance was evaluated by comparing ratings of 90 image pairs evaluated as clinically different and not clinically different. Photographic validation was completed as per live validation on the standardized images used for clinical relevance. RESULTS: For both scales, the live and photographic validation demonstrated almost perfect levels of intra-rater reliability (combined Kappas > 0.801) and substantial to almost-perfect inter-rater reliability (median pairwise Kappas > 0.728), across a diverse population. Clinical relevance showed a meaningful 1-point difference in pairs that are not clinically different and images with 1-point difference (p<0.001). CONCLUSIONS: The Canfield Skin Quality Scale - Skin Smoothness and the Canfield Skin Quality Scale - Cheek Lines are robust and reproducible outcome measures for use live and on images, supporting their use in clinical studies and practice across diverse populations. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of The Aesthetic Society. FAU - Lorenc, Z Paul AU - Lorenc ZP AD - Plastic surgeon in private practice, New York, NY. FAU - Bass, Lawrence S AU - Bass LS AD - Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY. FAU - Betz-Stablein, Brigid AU - Betz-Stablein B AUID- ORCID: 0000-0003-3876-501X AD - Canfield Scientific, Inc., Parsippany, NJ. FAU - Cramer, Lisa AU - Cramer L AD - Canfield Scientific, Inc., Parsippany, NJ. FAU - Canfield, Doug AU - Canfield D AD - Canfield Scientific, Inc., Parsippany, NJ. FAU - Jones, Derek AU - Jones D AD - Skin Care and Laser Physicians of Beverly Hills, Beverly Hills, CA. FAU - Koh, Uyen AU - Koh U AD - Canfield Scientific Pty Ltd, Dural, Australia. FAU - Melione, Anthony AU - Melione A AD - Canfield Scientific, Inc., Parsippany, NJ. FAU - Moradi, Amir AU - Moradi A AD - Pacific Clinical Innovations, Vista, CA. FAU - Vickers, Jennifer L AU - Vickers JL AD - Dermatologist in private practice in Austin, TX. FAU - Woodward, Julie A AU - Woodward JA AD - Duke Integrated Health Practice, Durham, NC. FAU - Smith, Stacy AU - Smith S AD - California Dermatology & Clinical Research Institute, Encinitas, CA. LA - eng PT - Journal Article DEP - 20261014 PL - England TA - Aesthet Surg J JT - Aesthetic surgery journal JID - 9707469 SB - IM EDAT- 2026/10/13 23:36 MHDA- 2026/10/13 23:36 CRDT- 2026/10/13 20:05 PHST- 2026/05/01 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/10/13 23:36 [medline] PHST- 2026/10/13 23:36 [pubmed] PHST- 2026/10/13 20:05 [entrez] AID - 8914573 [pii] AID - 10.1093/asj/sjag217 [doi] PST - aheadofprint SO - Aesthet Surg J. 2026 Oct 14:sjag217. doi: 10.1093/asj/sjag217. PMID- 42867877 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261015 IS - 2291-9279 (Print) IS - 2291-9279 (Electronic) VI - 14 DP - 2026 Oct 13 TI - Effects of Active Video Games on Cardiometabolic Health in Children and Adolescents: Systematic Review and Meta-Analysis of Randomized Controlled Trials. PG - e101833 LID - 10.2196/101833 [doi] LID - e101833 AB - BACKGROUND: Cardiometabolic risk factors emerging during childhood and adolescence may persist into adulthood and increase the risk of cardiovascular disease. Although physical activity improves cardiometabolic health, maintaining regular participation remains challenging. Active video games (AVG), which combine physical activity with video game enjoyment, may provide an engaging approach to promote physical activity participation. OBJECTIVE: This study aims to evaluate the effects of AVG on cardiometabolic health in children and adolescents and to explore potential moderators of these effects. METHODS: PubMed, Web of Science, the Cochrane Library, and Embase were searched from database inception to July 2026. Eligible randomized controlled trials (RCTs) evaluating AVG in children and adolescents aged 4-18 years were included, with comparisons against no intervention, sedentary video games, or regular physical activity. Random-effects meta-analyses were conducted to estimate pooled effects. Subgroup analyses explored potential moderators. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool (RoB 2; Cochrane), sensitivity analyses examined robustness, and small-study effects were evaluated when feasible. Certainty of evidence was assessed using GRADE (Grading of Recommendations Assessment, Development and Evaluation). RESULTS: A total of 14 RCTs involving 942 children and adolescents were included. AVG were associated with a small but significant reduction in BMI (Hedges g=-0.23, 95% CI -0.35 to -0.10; 95% prediction interval [PI] -0.43 to -0.01; P=.002). SBP (Hedges g=-0.18, 95% CI -0.36 to -0.001; 95% PI -0.43 to 0.07; P=.0497) showed a small statistically significant reduction, although the 95% PI crossed the null. No significant effects were observed for diastolic blood pressure (DBP) (Hedges g=-0.11, 95% CI -0.86 to 0.63; 95% PI -2.09 to 1.75; P=.59), high-density lipoprotein cholesterol (HDL) (Hedges g=0.05; 95% CI -0.21 to 0.31; 95% PI -0.54 to 0.57; P=.65), low-density lipoprotein cholesterol (LDL) (Hedges g=-0.26, 95% CI -0.64 to 0.13; 95% PI -1.18 to 0.69; P=.15), total cholesterol (TC) (Hedges g=-0.96, 95% CI -3.79 to 1.88; 95% PI -5.71 to 3.86; P=.37), triglycerides (Hedges g=-0.20, 95% CI -0.70 to 0.31; 95% PI -1.41 to 0.99; P=.38), heart rate (HR) (Hedges g=-0.14, 95% CI -1.74 to 1.46; 95% PI -4.23 to 5.38; P=.47), or glucose (Hedges g=-0.17, 95% CI -0.37 to 0.02; 95% PI -0.42 to 0.07; P=.07) following AVG. No significant BMI subgroup differences were observed by gender, intervention type, or nutritional status. CONCLUSIONS: This review extends previous evidence by providing an updated RCT-only evaluation of a broader pediatric population and a wider range of cardiometabolic outcomes. AVG were associated with small reductions in BMI and systolic blood pressure (SBP), although evidence for other cardiometabolic outcomes remains uncertain. By clarifying both potential benefits and remaining evidence gaps, this review provides a broader basis for future research and intervention development. AVG may serve as an engaging adjunct to support physical activity participation among children and adolescents. CI - (c) Wenqi Liu, Yuxin Wang, Tianle Wang, Chunji Zhao, Jun Li, Weixin Chen, Fanhao Meng. Originally published in JMIR Serious Games (https://games.jmir.org). FAU - Liu, Wenqi AU - Liu W AUID- ORCID: 0009-0002-3147-3946 AD - School of Arts, Beijing Sport University, No.48, Xinxi Road, Haidian District, Beijing, China, Beijing, Beijing, China. FAU - Wang, Yuxin AU - Wang Y AUID- ORCID: 0009-0007-1605-1522 AD - School of Physical Education, Shaanxi Normal University, No. 620, West Chang'an Street, Chang'an District, Xi'an, Shaanxi, China. FAU - Wang, Tianle AU - Wang T AUID- ORCID: 0009-0008-4834-1513 AD - School of Arts, Beijing Sport University, No.48, Xinxi Road, Haidian District, Beijing, China, Beijing, Beijing, China. FAU - Zhao, Chunji AU - Zhao C AUID- ORCID: 0009-0006-8017-7608 AD - School of Arts, Beijing Sport University, No.48, Xinxi Road, Haidian District, Beijing, China, Beijing, Beijing, China. FAU - Li, Jun AU - Li J AUID- ORCID: 0009-0005-9681-8433 AD - School of Physical Education, Shaanxi Normal University, No. 620, West Chang'an Street, Chang'an District, Xi'an, Shaanxi, China. FAU - Chen, Weixin AU - Chen W AUID- ORCID: 0009-0000-2111-5534 AD - School of Physical Education, Shaanxi Normal University, No. 620, West Chang'an Street, Chang'an District, Xi'an, Shaanxi, China. FAU - Meng, Fanhao AU - Meng F AUID- ORCID: 0009-0009-6954-8916 AD - University of Freiburg, Germany, Baden-Wurttemberg, Germany. LA - eng PT - Journal Article PT - Review DEP - 20261013 PL - Canada TA - JMIR Serious Games JT - JMIR serious games JID - 101645255 PMC - PMC13660585 OTO - NOTNLM OT - active video games OT - adolescents OT - cardiometabolic health OT - children OT - digital health OT - physical activity COIS- Conflicts of Interest: None declared EDAT- 2026/10/13 23:36 MHDA- 2026/10/13 23:37 PMCR- 2026/10/13 CRDT- 2026/10/13 17:38 PHST- 2026/05/20 00:00 [received] PHST- 2026/08/21 00:00 [revised] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/10/13 23:37 [medline] PHST- 2026/10/13 23:36 [pubmed] PHST- 2026/10/13 17:38 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - v14i1e101833 [pii] AID - 101833 [pii] AID - 10.2196/101833 [doi] PST - epublish SO - JMIR Serious Games. 2026 Oct 13;14:e101833. doi: 10.2196/101833. PMID- 42866734 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261013 IS - 2049-0801 (Print) IS - 2049-0801 (Electronic) IS - 2049-0801 (Linking) VI - 88 IP - 10 DP - 2026 Oct TI - Ultrasonographic changes following pyeloplasty in children with ureteropelvic junction obstruction: a prospective observational before-after cohort study. PG - 6454-6459 LID - 10.1097/MS9.0000000000005679 [doi] AB - BACKGROUND/OBJECTIVE: Ureteropelvic junction obstruction (UPJO) is a common congenital anomaly in pediatric patients. Although nuclear scintigraphy is traditionally considered the standard for postoperative follow-up, the associated radiation exposure, invasiveness, and cost have prompted interest in noninvasive options. This study evaluated postoperative ultrasonographic changes as a first-line surveillance tool for children undergoing pyeloplasty. METHODS: This prospective observational before-after cohort study (March 2023-March 2024) evaluated 50 children (38 girls, 12 boys) treated for primary congenital UPJO. All underwent open pyeloplasty by two experienced surgeons, with Double-J stents removed at 4 weeks. Preoperative and 3-month postoperative evaluations compared sonographic parameters [anteroposterior pelvic diameter (APD), cortical thickness, renal length, hydronephrosis severity], diethylenetriamine pentaacetic acid renal scintigraphy, and biochemical markers. Surgical success was defined as clinical improvement alongside stable or improved sonography without the need for reintervention. RESULTS: Postoperatively, significant reductions were observed in APD, hydronephrosis grade, serum creatinine, BUN, and random urine creatinine (all P < 0.001). Conversely, cortical thickness and renal length significantly increased bilaterally (all P < 0.001). Differential renal function was effectively preserved, with no significant postoperative changes (right: P = 0.209; left: P = 0.189). Additionally, patient age demonstrated significant positive correlations with multiple postoperative sonographic and biochemical parameters. CONCLUSION: Ultrasonography is a safe, reliable, and practical first-line surveillance tool for post-pyeloplasty follow-up. Nuclear renography can be selectively reserved for patients showing clinical deterioration or a lack of sonographic improvement. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, LLC. FAU - Izadfar, Farnoush AU - Izadfar F AD - Department of Pediatric Surgery, Akbar Children's Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Abbasioun, Reza AU - Abbasioun R AD - Department of Pediatric Urology, Akbar Children's Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Mohammadipour, Ahmad AU - Mohammadipour A AD - Department of Pediatric Surgery, Akbar Children's Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Saadat, Sara AU - Saadat S AD - Department of Pediatric Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Abrishami, Mostafa AU - Abrishami M AD - Department of Pediatric Surgery, Akbar Children's Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Fayez, Sayed Morteza AU - Fayez SM AD - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Alvandi Fard, Mohammad Mahdi AU - Alvandi Fard MM AD - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Atqiaee, Khashayar AU - Atqiaee K AUID- ORCID: 0000-0003-0421-1334 AD - Department of Pediatric Surgery, Akbar Children's Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. LA - eng PT - Journal Article DEP - 20260916 PL - England TA - Ann Med Surg (Lond) JT - Annals of medicine and surgery (2012) JID - 101616869 PMC - PMC13657483 OTO - NOTNLM OT - child OT - hydronephrosis OT - pyeloplasty OT - ultrasonography OT - ureteral obstruction COIS- There are no conflicts of interest to declare. EDAT- 2026/10/13 18:26 MHDA- 2026/10/13 18:27 PMCR- 2026/09/16 CRDT- 2026/10/13 14:50 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/10/13 18:27 [medline] PHST- 2026/10/13 18:26 [pubmed] PHST- 2026/10/13 14:50 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - AMSU-D-26-02237 [pii] AID - 10.1097/MS9.0000000000005679 [doi] PST - epublish SO - Ann Med Surg (Lond). 2026 Sep 16;88(10):6454-6459. doi: 10.1097/MS9.0000000000005679. eCollection 2026 Oct. PMID- 42866214 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 9 DP - 2026 Sep 30 TI - Predictors of using biologics within one year after EEN therapy in pediatric Crohn's disease. PG - 381 LID - 10.21037/tp-2026-0515 [doi] LID - 381 AB - BACKGROUND: Biologics are commonly used as the second-line medication for maintenance of remission after exclusive enteral nutrition (EEN) induction in pediatric Crohn's disease (CD). However, predictors of using biologics after EEN therapy in CD are yet to be elucidated. This study explores the predictive factors for the application of biologics in children with CD who had finished 8 weeks of EEN induction. METHODS: Seventy-five patients were divided into derivation group (n=54) and validation group (n=21). Baseline characteristics were compared between biological group and non-biological group. Univariate and multivariate analyses were performed to correlate 102 laboratory indicators. Finally, binary stepwise logistic regression was used to construct a prediction model. RESULTS: The predictor identified for biologic use in the prediction model was complement C4 and red blood cell distribution width (RDW). Complement C4 [odds ratio (OR) =1.04, 95% confidence interval (CI): 1.01-1.07] and RDW (OR =1.41, 95% CI: 1.05-1.91) were identified as significant independent predictors (P<0.05). Patients with baseline complement C4 levels >0.415 g/L and RDW >13.5% were more likely to use biologics within 1 year after EEN. CONCLUSIONS: Complement C4 and RDW are predictors of biologic use within 1 year after EEN-induced clinical remission. Elevated complement C4 and RDW are associated with the use of biologics after induction of remission. However, extensive experimental validation is still required to confirm the above findings. CI - (c) AME Publishing Company. FAU - Wang, Xiaoxi AU - Wang X AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Hu, Yudie AU - Hu Y AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Lou, Jingan AU - Lou J AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Luo, Youyou AU - Luo Y AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Yu, Jindan AU - Yu J AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Fang, Youhong AU - Fang Y AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Tang, Lujing AU - Tang L AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Zhao, Hong AU - Zhao H AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Xu, Luojia AU - Xu L AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Peng, Kerong AU - Peng K AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Lv, Yao AU - Lv Y AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Chen, Jie AU - Chen J AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. LA - eng PT - Journal Article DEP - 20260817 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13655871 OTO - NOTNLM OT - Inflammatory bowel disease (IBD) OT - biologic OT - children OT - induction therapy OT - prediction COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0515/coif). The authors have no conflicts of interest to declare. EDAT- 2026/10/13 17:37 MHDA- 2026/10/13 17:38 PMCR- 2026/09/30 CRDT- 2026/10/13 13:27 PHST- 2026/05/26 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/10/13 17:38 [medline] PHST- 2026/10/13 17:37 [pubmed] PHST- 2026/10/13 13:27 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - tp-15-9-381 [pii] AID - 10.21037/tp-2026-0515 [doi] PST - ppublish SO - Transl Pediatr. 2026 Sep 30;15(9):381. doi: 10.21037/tp-2026-0515. Epub 2026 Aug 17. PMID- 42866152 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 9 DP - 2026 Sep 30 TI - Treatment of idiopathic segmental infarction of the greater omentum in children via transumbilical single-port laparoscopy. PG - 368 LID - 10.21037/tp-2026-0430 [doi] LID - 368 AB - BACKGROUND: Idiopathic segmental infarction of the omentum represents a rare etiology of acute abdominal pain in pediatric patients. The atypical clinical presentation often leads to misdiagnosis and delayed intervention. This study aimed to summarize the treatment procedure of idiopathic segmental infarction of the omentum in children via transumbilical single-port laparoscopy and to offer a reference for clinical diagnosis and management of this condition. METHODS: Clinical information, including blood tests, imaging examinations, intraoperative findings, postoperative pathological results, and follow-up outcomes, was collected from children with idiopathic segmental infarction of the omentum at our institution from September 2023 to September 2025, and a retrospective analysis was conducted. RESULTS: There were 1 girl and 7 boys, whose ages ranged from 7 to 11 years, with an average of 9.1+/-1.2 years, and whose body mass index (BMI) ranged from 18.35 to 24.00 kg/m(2,) with an average of 21.95+/-2.11 kg/m(2) among the 8 pediatric patients. The initial symptom was abdominal pain without any other accompanying symptoms. Ultrasound examinations revealed a hyperechoic abdominal mass in each patient without obvious blood flow signals, and computed tomography (CT) examinations revealed a mixed-density shadow mass in the abdomen without significant enhancement. Postoperative pathology confirmed infarction of the greater omentum, consistent with the preoperative diagnosis. All patients underwent transumbilical single-port laparoscopic surgery, with a hospital stay of 3-7 days and an average duration of 4.88+/-1.55 days. No complications, such as intestinal obstruction or incisional hernia, were observed during an average follow-up period of 21 months. CONCLUSIONS: Transumbilical single-port laparoscopic surgery is safe, effective, and feasible for treating idiopathic segmental infarction of the omentum in children, and could serve as an alternative surgical approach for this condition. CI - (c) AME Publishing Company. FAU - Hong, Yinan AU - Hong Y AD - Department of Pediatric Surgery, Quanzhou Maternal and Children's Hospital (Quanzhou Children's Hospital), Quanzhou, China. FAU - Chen, Weiming AU - Chen W AD - Department of Pediatric Surgery, Quanzhou Maternal and Children's Hospital (Quanzhou Children's Hospital), Quanzhou, China. FAU - Wu, Huazhe AU - Wu H AD - Department of Pediatric Surgery, Quanzhou Maternal and Children's Hospital (Quanzhou Children's Hospital), Quanzhou, China. FAU - Zeng, Hongbiao AU - Zeng H AD - Department of Pediatric Surgery, Quanzhou Maternal and Children's Hospital (Quanzhou Children's Hospital), Quanzhou, China. FAU - Wei, Yongjuan AU - Wei Y AD - Department of Pediatric Surgery, Quanzhou Maternal and Children's Hospital (Quanzhou Children's Hospital), Quanzhou, China. LA - eng PT - Journal Article DEP - 20260828 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13655819 OTO - NOTNLM OT - Transumbilical single-port laparoscopy OT - body mass index (BMI) OT - children OT - idiopathic segmental infarction of the greater omentum (ISIGO) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0430/coif). The authors have no conflicts of interest to declare. EDAT- 2026/10/13 17:37 MHDA- 2026/10/13 17:38 PMCR- 2026/09/30 CRDT- 2026/10/13 13:22 PHST- 2026/05/03 00:00 [received] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/10/13 17:38 [medline] PHST- 2026/10/13 17:37 [pubmed] PHST- 2026/10/13 13:22 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - tp-15-9-368 [pii] AID - 10.21037/tp-2026-0430 [doi] PST - ppublish SO - Transl Pediatr. 2026 Sep 30;15(9):368. doi: 10.21037/tp-2026-0430. Epub 2026 Aug 28. PMID- 42866018 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - School-based high-intensity interval training for children: a focused systematic review of implementation and school-relevant outcomes. PG - 1952928 LID - 10.3389/fped.2026.1952928 [doi] LID - 1952928 AB - BACKGROUND: Schools are an important setting for physical-activity promotion, but limited curriculum time can constrain the implementation of exercise programmes. High-intensity interval training (HIIT) may offer a brief format for increasing vigorous activity during physical education (PE), classroom activity breaks, or other school-day opportunities. This review examined school-based HIIT delivery models, physical and cardiovascular outcomes, cognition and other school-relevant outcomes, and implementation, feasibility, and safety reporting. METHODS: Five electronic databases were searched for English-language studies published from January 2010 to May 9, 2026. Two reviewers independently screened records, assessed full texts, extracted data, and appraised risk of bias, with disagreements resolved by consensus. Eligible controlled studies evaluated a clearly defined HIIT intervention delivered in a school setting to children aged approximately 5-12 years and reported at least one physical, cardiovascular, cognitive, school-relevant, or implementation outcome. Owing to substantial heterogeneity in interventions and outcomes, findings were synthesised narratively in accordance with the Synthesis Without Meta-analysis (SWiM) reporting guideline. RESULTS: The searches identified 3,508 records; 1,370 duplicates were removed, 2,138 records were screened, 94 full-text reports were assessed, and six studies were included. Analysed sample sizes ranged from 18 to 67 participants. Interventions ranged from 6-minute classroom micro-sessions to 20-minute PE-based programmes delivered for 4-12 weeks. Some studies reported between-group or group-by-time findings favouring HIIT for selected functional-strength, aerobic-fitness, arterial-stiffness, and heart-rate-variability outcomes; other findings were limited to within-group change, and effects were not consistent across protocols. One study assessed inhibitory control and reported improvements after both HIIT and moderate-intensity continuous training, providing no evidence of a HIIT-specific cognitive advantage. No included study directly assessed mental health, academic attainment, attendance, or classroom engagement. Three studies were judged to have a high overall risk of bias and three raised some concerns. CONCLUSIONS: School-based HIIT may be a brief adjunct to, rather than a replacement for, comprehensive PE. Preliminary findings suggest possible benefits for selected fitness and cardiovascular outcomes, while evidence for cognitive, mental-health, and academic benefits remains limited or absent. Given the small evidence base and risk-of-bias concerns, these findings should be interpreted cautiously. The current findings apply to the primary-school-aged samples represented and should not be extrapolated to adolescents. Larger, adequately powered school trials with stronger implementation and outcome reporting are required. CI - (c) 2026 Yang, Lin and Lan. FAU - Yang, Lizhuo AU - Yang L AD - Wuhan Sports University, Wuhan, Hubei, China. FAU - Lin, Liping AU - Lin L AD - Guandian Middle School, Mingguang, Anhui, China. FAU - Lan, Zhuomei AU - Lan Z AD - Guandian Hospital, Mingguang, Anhui, China. LA - eng PT - Journal Article PT - Review DEP - 20260928 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13655682 OTO - NOTNLM OT - children OT - high-intensity interval training OT - narrative synthesis OT - physical education OT - school-based intervention OT - systematic review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 17:37 MHDA- 2026/10/13 17:38 PMCR- 2026/09/28 CRDT- 2026/10/13 12:33 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/13 17:38 [medline] PHST- 2026/10/13 17:37 [pubmed] PHST- 2026/10/13 12:33 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fped.2026.1952928 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 28;14:1952928. doi: 10.3389/fped.2026.1952928. eCollection 2026. PMID- 42866012 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - Gut microbiota and health-related quality of life in paediatric inherited metabolic disorders: a narrative review and conceptual framework. PG - 1928657 LID - 10.3389/fmicb.2026.1928657 [doi] LID - 1928657 AB - Inherited metabolic disorders (IMDs) comprise more than 1,400 rare genetic conditions affecting paediatric patients worldwide. Despite advances in newborn screening and dietary management, many children experience chronic complications, gastrointestinal symptoms, and reduced health-related quality of life (HRQoL). Emerging evidence-predominantly from phenylketonuria (PKU)-suggests that gut microbiota may influence metabolic homeostasis and patient-centred outcomes in affected children. Because of substantial methodological heterogeneity and the rarity of individual disorders, we elected a narrative review format to synthesise current evidence rather than a formal quantitative synthesis. Electronic searches were performed in PubMed, Embase, and Web of Science from inception to February 2026. We synthesise current evidence regarding gut microbiota composition in major paediatric IMDs, including PKU, organic acidemias, glycogen storage diseases, lysosomal storage disorders, and mitochondrial diseases. For PKU, controlled studies report reduced microbial diversity and depletion of butyrate-producing taxa associated with long-term dietary treatment. For the remaining disorders, direct paediatric microbiome data are sparse or absent, and proposed links rely on mechanistic extrapolation from non-IMD populations. We present the gut microbiota-metabolism-quality of life axis as a conceptual framework that integrates microbial metabolites, intestinal barrier function, immune signalling, and patient-reported outcomes, while emphasising that direct causal evidence linking microbiota alterations to HRQoL in paediatric IMDs is currently lacking. Microbiota-directed interventions remain preliminary. Future multicentre longitudinal studies integrating microbiome profiling, multi-omics technologies, and validated patient-reported outcomes are needed to clarify causal mechanisms and therapeutic potential. Importantly, the available evidence is heterogeneous: direct paediatric microbiome evidence is strongest for PKU, whereas evidence for other IMDs is sparse and often observational, preclinical, or extrapolated from non-IMD populations. The proposed microbiota-metabolism-HRQoL axis is therefore presented as a hypothesis-generating framework rather than an established causal pathway. CI - Copyright (c) 2026 Dumbuya, Li, He, Li, Liu, Zhong, Huang and Chen. FAU - Dumbuya, John Sieh AU - Dumbuya JS AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Li, Yuanlong AU - Li Y AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - He, Bo AU - He B AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Li, Guangxu AU - Li G AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Liu, Yuting AU - Liu Y AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Zhong, Youfeng AU - Zhong Y AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Huang, Shimei AU - Huang S AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Chen, Xiuling AU - Chen X AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. LA - eng PT - Journal Article PT - Review DEP - 20260928 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC13655685 OTO - NOTNLM OT - gut microbiota OT - health-related quality of life OT - inherited metabolic disorders OT - narrative review OT - phenylketonuria OT - probiotics OT - short-chain fatty acids COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 17:37 MHDA- 2026/10/13 17:38 PMCR- 2026/09/28 CRDT- 2026/10/13 12:31 PHST- 2026/07/05 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/13 17:38 [medline] PHST- 2026/10/13 17:37 [pubmed] PHST- 2026/10/13 12:31 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1928657 [doi] PST - epublish SO - Front Microbiol. 2026 Sep 28;17:1928657. doi: 10.3389/fmicb.2026.1928657. eCollection 2026. PMID- 42865937 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Climate awareness and lower-meat eating among children and adolescents: potential behavioral pathways and contextual conditions. PG - 1967214 LID - 10.3389/fnut.2026.1967214 [doi] LID - 1967214 AB - Climate awareness is increasingly proposed as a motive for lower-meat eating, while research involving children and adolescents spans distinct outcomes, from knowledge and willingness to food provision and measured intake. This Mini Review synthesizes these outcome levels and the conditions that connect them. A targeted structured search of Web of Science and Scopus identified surveys, qualitative studies, message and food-education interventions, family and school provision studies, and nutritional analyses. Evidence was organized as climate-linked motivational, proximal behavioral, and intake-association evidence; provision- and intake-change evidence; and contextual or feasibility evidence. Climate-related motives coexist with health, taste, identity, convenience, and social norms. One preregistered study comprising two randomized message experiments reported changes in immediate sustainable choices and intentions. A cross-sectional youth analysis linked climate attitudes with current intake, retrospectively reported reduction, and future intention, whereas a provision-based family trial supplied the clearest within-study change in meat intake. Family gatekeeping, school-food systems, product acceptability, culture, affordability, nutrition, and equity shape opportunities across these routes. Age changes opportunities for dietary agency: decision control may be adult-led, shared, or youth-led within age groups and settings. Climate awareness therefore occupies one motivational position in a multilevel evidence map. Connecting motivation with acceptable, accessible, and nutritionally adequate food environments provides a testable framework for sustained dietary change. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article PT - Review DEP - 20260928 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13656206 OTO - NOTNLM OT - adolescents OT - alternative proteins OT - children OT - climate awareness OT - lower-meat eating OT - school meals OT - sustainable diets COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 17:37 MHDA- 2026/10/13 17:38 PMCR- 2026/09/28 CRDT- 2026/10/13 12:05 PHST- 2026/08/13 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/13 17:38 [medline] PHST- 2026/10/13 17:37 [pubmed] PHST- 2026/10/13 12:05 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fnut.2026.1967214 [doi] PST - epublish SO - Front Nutr. 2026 Sep 28;13:1967214. doi: 10.3389/fnut.2026.1967214. eCollection 2026. PMID- 42865672 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-4185 (Print) IS - 2296-4185 (Electronic) IS - 2296-4185 (Linking) VI - 14 DP - 2026 TI - Tibiotarsal mechanical behaviour is mainly a function of bone structure and not mineral density in female adolescent chickens. PG - 1812701 LID - 10.3389/fbioe.2026.1812701 [doi] LID - 1812701 AB - INTRODUCTION: Bone fragility and disuse osteoporosis in commercial egg-laying chickens is a major welfare concern. Efforts to address this have focused on eliciting increases in bone mass during growth by raising chickens in more spacious and complex housing systems that motivate increased physical activity. However, it remains unclear how these bone adaptations influence in vivo bone mechanical behaviour in chickens, namely, whole-bone stiffness and strength. METHODS: To investigate this, we sampled female chickens of two genetic strains (Lohmann Brown: brown-feathered, Lohmann LSL Lite: white-feathered) with different loading histories (sedentary: housed in cages with no opportunity for dynamic load bearing activity; active: raised in one of two styles of aviary housing systems requiring locomotion including jumping and other aerial transitions) just prior to the onset of sexual maturity at 16 weeks of age. We imaged their whole right tibiotarsi (ex vivo) using microCT and for the first time developed finite element models of the chicken tibiotarsi under controlled in vivo axial compressive loading on a limited sample size (n = 1, N = 6), which we validated with in vivo strain gauge measurements. Each bone was modelled with both homogeneous and heterogeneous material properties to assess the effects of tissue mineral density and bone structure on the mechanical behaviour. We also quantified a variety of structural measures along the bone length and determined their correlation to simulated mechanical behaviour. RESULTS: We found that consideration of volumetric tissue mineralization heterogeneity in our FE models had negligible influence on the modelled mechanical behaviour, and thus further analyses used only homogeneous FEMs. We identified bone area, total area, bone area ratio, bone thickness, eccentricity, normalized outer perimeter, and inner-to-outer perimeter ratio to be significantly correlated to decreased modelled stress. Increased activity levels was associated with lower modelled stresses in brown-, but not white-feathered chickens, and this pattern could be explained by differences in bone area, total area, and inner-to-outer perimeter ratio. CONCLUSION: These results suggest that, similar to what has been shown in humans, bone structure and not just mineral density is a critical determinant of mechanical behaviour and therefore fracture risk. We identify structural outcomes that can be candidates for genetic selection, targeting improved bone strength, a subset of which may adapt to loading in brown-feathered chickens. We also present a novel (in the poultry science field) approach to assess the relationship between bone structure and mechanical behaviour, which can be further used to inform genetic selection and breeding for improved bone strength and fracture resistance. CI - Copyright (c) 2026 Vitienes, Julien, Rentsch, Main, Widowski, Checa and Willie. FAU - Vitienes, Isabela AU - Vitienes I AD - Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada. AD - Research Centre, Shriners Hospital for Children-Canada, Montreal, QC, Canada. AD - Department of Operative, Preventive and Pediatric Dentistry, Charite - Universitatsmedizin, Berlin, Germany. FAU - Julien, Catherine AU - Julien C AD - Research Centre, Shriners Hospital for Children-Canada, Montreal, QC, Canada. AD - Faculty of Dental Medicine and Oral Health Science, McGill University, Montreal, QC, Canada. FAU - Rentsch, Ana K AU - Rentsch AK AD - Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada. FAU - Main, Russell P AU - Main RP AD - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States. AD - Department of Basic Medical Sciences, Purdue University, Purdue, IN, United States. FAU - Widowski, Tina M AU - Widowski TM AD - Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada. FAU - Checa, Sara AU - Checa S AD - Julius Wolff Institute, Charite-Universitatsmedizin Berlin, Berlin, Germany. AD - Institute of Biomechanics, Hamburg University of Technology (TUHH), Hamburg, Germany. FAU - Willie, Bettina M AU - Willie BM AD - Research Centre, Shriners Hospital for Children-Canada, Montreal, QC, Canada. AD - Faculty of Dental Medicine and Oral Health Science, McGill University, Montreal, QC, Canada. AD - College of Veterinary Medicine, Utah State University, Logan, UT, United States. LA - eng PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Bioeng Biotechnol JT - Frontiers in bioengineering and biotechnology JID - 101632513 PMC - PMC13655523 OTO - NOTNLM OT - bone adaptation OT - bone fragility OT - bone mechanical behaviour OT - bone structure OT - egg-laying hens COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 09:30 PHST- 2026/02/17 00:00 [received] PHST- 2026/07/15 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 09:30 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 1812701 [pii] AID - 10.3389/fbioe.2026.1812701 [doi] PST - epublish SO - Front Bioeng Biotechnol. 2026 Sep 28;14:1812701. doi: 10.3389/fbioe.2026.1812701. eCollection 2026. PMID- 42865505 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261014 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Evaluating the implementation of the Diabetes Body Project in a clinical cohort of Australian adolescents with type 1 diabetes. PG - 1958711 LID - 10.3389/fendo.2026.1958711 [doi] LID - 1958711 AB - INTRODUCTION: Adolescents with type 1 diabetes (T1D) are at increased risk of disordered eating behaviors (DEB) and eating disorders (ED) compared to their peers without T1D, contributing to increased diabetes-related complications, and elevated mortality risk. Despite this, there is a lack of targeted ED prevention interventions specifically designed for adolescents with T1D, within routine clinical care. The Diabetes Body Project (DBP) has demonstrated promising feasibility, acceptability, and reduction of DEB in young adults; however, its application in younger adolescents and real-world clinical settings has not been tested. OBJECTIVE: This study aims to extend previous DBP research by evaluating its implementation within a real-world Australian clinical service. The study will assess feasibility and acceptability and explore preliminary efficacy in relation to DEB and glycaemic control in an exclusively adolescent population, including a novel parent/caregiver component. METHODS: This protocol describes a pilot study that will recruit 24 female adolescents with T1D from the John Hunter Children's Hospital (JHCH) Diabetes Service in New South Wales, Australia, along with up to 24 parents/caregivers. Adolescents will participate in a 6-week virtually delivered manualised cognitive dissonance based DBP program, delivered in a group format across four cohorts of 6 adolescents. In addition, two group sessions will be developed and delivered virtually to parents/caregivers for each cohort. Outcomes will be assessed at baseline, post-intervention and at 3 and 6 months follow up. Feasibility will be evaluated through recruitment, retention, attendance, between-session activity completion and parent/caregiver uptake. Acceptability will be assessed via participant and caregiver satisfaction surveys. Preliminary efficacy will be explored through changes in disordered eating behaviors (Diabetes Eating Problem Survey-Revised), body appreciation (BAS-2), diabetes distress (PAID-T), and glycaemic outcomes. DISCUSSION: This study will evaluate the implementation of an adapted DBP intervention for adolescents with T1D within a real-world clinical service. By incorporating a novel parent/caregiver component and targeting the adolescent population, the study addresses key gaps in current literature. Findings may inform the design of future larger-scale trials and support the integration of ED prevention strategies into routine pediatric diabetes care. CI - Copyright (c) 2026 Fisher, Pursey, Leigh, King and Smart. FAU - Fisher, Emma L AU - Fisher EL AD - Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, New Lambton Heights, NSW, Australia. AD - School of Health Sciences, College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia. FAU - Pursey, Kirrilly M AU - Pursey KM AD - School of Health Sciences, College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Leigh, Lucy AU - Leigh L AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - School of Medicine and Public Health, College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia. FAU - King, Bruce R AU - King BR AD - Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, New Lambton Heights, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Smart, Carmel E AU - Smart CE AD - Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, New Lambton Heights, NSW, Australia. AD - School of Health Sciences, College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. LA - eng PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/complications/therapy MH - Adolescent MH - Female MH - *Feeding and Eating Disorders/prevention & control/etiology/psychology MH - Pilot Projects MH - Australia/epidemiology MH - Male MH - Cohort Studies PMC - PMC13654795 OTO - NOTNLM OT - adolescents OT - eating disorder OT - pilot OT - prevention OT - type 1 diabetes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 07:31 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 07:31 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fendo.2026.1958711 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 28;17:1958711. doi: 10.3389/fendo.2026.1958711. eCollection 2026. PMID- 42865446 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - A data-driven stratification framework for physical fitness in junior high school students: a composite approach based on BMI and multidimensional data. PG - 1959431 LID - 10.3389/fpubh.2026.1959431 [doi] LID - 1959431 AB - OBJECTIVE: To overcome the practical challenges of implementing differentiated instruction in large physical education (PE) classes, this study develops a composite stratification framework. This exploratory framework provides a baseline for precise, individualized physical fitness interventions in adolescents. METHODS: A quantitative cross-sectional design was employed. First, a questionnaire survey was administered to 125 primary and secondary school PE teachers in Beijing to evaluate their attitudes and preferences for evaluation indicators regarding differentiated instruction. Second, multidimensional physical fitness monitoring data were collected from 532 junior high school students. Following the standardization of continuous physical fitness test scores and categorization by Body Mass Index (BMI), one-way analysis of variance (ANOVA) and K-means clustering algorithms were comprehensively applied to explore the underlying latent cluster formations of students' multidimensional physical fitness characteristics. RESULTS: The survey revealed a high theoretical acceptance of differentiated instruction among frontline teachers, yet a "knowing-doing gap" remains in large-class settings, with 65.85% of respondents prioritizing BMI as the primary stratification criterion. ANOVA confirmed significant differences in physical fitness scores across BMI groups, validating its preliminary screening value. However, it also demonstrated that relying on a single morphological indicator easily obscures the micro-heterogeneity of unbalanced physical performance. The introduction of multidimensional data clustering successfully grouped male students into 2 clusters and female students into 3 clusters, effectively controlling pedagogical stratification tiers and intra-group variance. CONCLUSION: The composite stratification framework-integrating initial BMI screening with multidimensional physical fitness data clustering-serves as an exploratory framework for identifying heterogeneous fitness profiles. Because this study identifies statistical subgroups cross-sectionally without prospective interventions or safety monitoring, it does not constitute a validated educational strategy. Its practical pedagogical effectiveness, longitudinal stability, and safety require rigorous external validation studies. CI - Copyright (c) 2026 Fang, Hou and Wen. FAU - Fang, Yi AU - Fang Y AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Hou, Juhao AU - Hou J AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Wen, Shilin AU - Wen S AD - Capital University of Physical Education and Sports, Beijing, China. LA - eng PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - *Physical Fitness/physiology MH - Humans MH - *Body Mass Index MH - Cross-Sectional Studies MH - *Physical Education and Training MH - Female MH - Male MH - Adolescent MH - Clustering Algorithms MH - Surveys and Questionnaires MH - *Students/statistics & numerical data MH - Cluster Analysis MH - Beijing PMC - PMC13654965 OTO - NOTNLM OT - adolescent health OT - body mass index (BMI) OT - cluster analysis OT - differentiated instruction OT - physical fitness COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 06:43 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/04 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 06:43 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1959431 [doi] PST - epublish SO - Front Public Health. 2026 Sep 28;14:1959431. doi: 10.3389/fpubh.2026.1959431. eCollection 2026. PMID- 42865444 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Physical activity, entertainment screen time, and dietary fat profiles and concurrent weight status among school-attending Chinese children and adolescents: CHNS 2004-2011. PG - 1945546 LID - 10.3389/fpubh.2026.1945546 [doi] LID - 1945546 AB - BACKGROUND: Physical activity, screen-based leisure, and diet co-occur, but profiles estimated from a small set of indicators may be sensitive to historical period and model assumptions. We identified profiles defined by total physical activity, reported entertainment screen time, and dietary fat contribution to energy intake in the 2004-2011 China Health and Nutrition Survey (CHNS), and examined their concurrent associations with weight status. METHODS: This pooled cross-sectional analysis included 4,112 person-wave observations from school-attending participants aged 6-17 years. A prespecified Gaussian mixture analysis compared one through six profiles. Associations with measured overweight/obesity were estimated in 4,068 observations from 2,757 participants using posterior-probability pseudo-class draws and participant-clustered robust standard errors. Wave-, age-, model-specification-, missing-data-, and alternative-outcome analyses assessed robustness. RESULTS: The prespecified model retained five profiles: very low activity (6.9%), low-to-moderate activity/lower fat (37.8%), no reported entertainment screen time (5.4%), higher fat (27.8%), and highly active (22.2%). The exact BIC-preferred number of profiles varied across survey waves, age groups, and model specifications, and 48.4% of observations had a maximum posterior probability below 0.70. The estimated prevalence of overweight/obesity, accounting for profile-membership uncertainty, was highest in the very-low-activity profile (24.4%) and was 16.4% in the reference profile. This descriptive difference attenuated after adjustment (odds ratio, 1.18; 95% confidence interval, 0.81-1.69), and the fully adjusted global profile test was non-significant (p = 0.806). Multinomial models separating overweight and obesity, continuous BMI and approximate WHO BMI-for-age z-score models, multiple imputation, and inverse-probability weighting produced the same overall conclusion. CONCLUSION: In the 2004-2011 CHNS analytic sample, the measured behaviors formed heterogeneous combinations, but the selected profiles did not independently distinguish concurrent weight status after adjustment. The findings are historical and sample-specific; they should not be interpreted as current national profile distributions or as validation of profile-based interventions. CI - Copyright (c) 2026 Qin, Wang, Zhang, Sheng, Jiang, Cheng and Wang. FAU - Qin, Boao AU - Qin B AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Wang, Changyang AU - Wang C AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Zhang, Yuchen AU - Zhang Y AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Sheng, Linwei AU - Sheng L AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Jiang, Xiaobo AU - Jiang X AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Cheng, Chen AU - Cheng C AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Wang, Yukuo AU - Wang Y AD - School of Physical Education, Yanshan University, Qinhuangdao, China. LA - eng GR - R01 HD030880/HD/NICHD NIH HHS/United States GR - R01 DK104371/DK/NIDDK NIH HHS/United States GR - R01 AG065357/AG/NIA NIH HHS/United States GR - R01 HL108427/HL/NHLBI NIH HHS/United States GR - D43 TW009077/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Dietary Fats) RN - Chinese people SB - IM MH - Humans MH - Child MH - *Screen Time MH - China/epidemiology MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - Male MH - Nutrition Surveys MH - *Exercise MH - *Dietary Fats/administration & dosage MH - Overweight/epidemiology MH - *Body Weight MH - East Asian People PMC - PMC13654989 OTO - NOTNLM OT - China Health and Nutrition Survey OT - behavioral profiles OT - children and adolescents OT - dietary fat OT - entertainment screen time OT - latent profile analysis OT - physical activity OT - weight status COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 06:39 PHST- 2026/07/22 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 06:39 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1945546 [doi] PST - epublish SO - Front Public Health. 2026 Sep 28;14:1945546. doi: 10.3389/fpubh.2026.1945546. eCollection 2026. PMID- 42865130 OWN - NLM STAT- Publisher LR - 20261022 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Oct 12 TI - Early lactation breast milk protein and lactose as independent predictors of infant regurgitation: A prospective cohort study. LID - 10.1002/jpn3.70600 [doi] AB - OBJECTIVES: To examine whether breast milk (BM) macronutrient composition in the first 2 weeks postpartum is associated with subsequent infant regurgitation (IR) risk, independent of maternal dietary intake. METHODS: In this prospective cohort study (Beijing, China), 78 mother-infant dyads were followed for 5 months. BM samples were collected at 1-2 weeks, 1, 2, and 5 months postpartum. IR was diagnosed using Rome IV criteria. Macronutrient composition (protein, fat, lactose) was analyzed using standardized methods. Maternal diet was assessed via a validated food frequency questionnaire. Multivariable logistic regression adjusted for maternal (body mass index, gestational age) and infant (birth weight, gender) characteristics. RESULTS: IR incidence peaked at 1 month (61.5%) and declined thereafter. Compared with controls, infants who developed IR at 1-2 months were exposed to lower protein and higher lactose concentrations in BM collected at 1-2 weeks (p < 0.05 for both). Maternal dietary intake was not associated with BM macronutrient composition. In adjusted models, lower early BM protein (odds ratio [OR] 0.090; 95% confidence interval [CI] 0.012-0.670) and higher lactose (OR 2.571; 95% CI 1.039-6.363) were associated with increased IR risk at 1 month. CONCLUSIONS: Early BM composition may be associated with subsequent IR risk, independent of maternal diet. Protein and lactose levels in early lactation may serve as potential markers for identifying infants at risk. These findings suggest early lactation as a sensitive period linking maternal physiology to infant gastrointestinal outcomes. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Li, Pei AU - Li P AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Wu, Dan AU - Wu D AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Jiang, Yilun AU - Jiang Y AUID- ORCID: 0009-0008-1232-0171 AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Beijing, China. FAU - Lu, Shuangmei AU - Lu S AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Peng, Jing AU - Peng J AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Yang, Chun AU - Yang C AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Beijing, China. FAU - Li, Peng-Gao AU - Li PG AUID- ORCID: 0000-0001-9134-5116 AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Beijing, China. LA - eng GR - CNS-Feihe2021-42/Chinese Nutrition Society/ PT - Journal Article DEP - 20261012 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - early life nutrition OT - gastrointestinal symptoms OT - infant feeding OT - maternal diet OT - risk factors EDAT- 2026/10/13 05:31 MHDA- 2026/10/13 05:31 CRDT- 2026/10/13 03:03 PHST- 2026/07/29 00:00 [revised] PHST- 2026/04/20 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/13 05:31 [pubmed] PHST- 2026/10/13 05:31 [medline] PHST- 2026/10/13 03:03 [entrez] AID - 10.1002/jpn3.70600 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Oct 12. doi: 10.1002/jpn3.70600. PMID- 42864684 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 2049-9957 (Electronic) IS - 2095-5162 (Print) IS - 2049-9957 (Linking) VI - 15 IP - 1 DP - 2026 Oct 12 TI - Pragmatic weight estimation for dosing of a new paediatric treatment for schistosomiasis prevention and control in preschool-aged children: a feasibility study in Uganda and Cote d'Ivoire. LID - 10.1186/s40249-026-01507-9 [doi] LID - 108 AB - BACKGROUND: Schistosomiasis remains a major public health concern in endemic settings. The Pediatric Praziquantel Consortium has developed a new paediatric treatment, arpraziquantel, for preschool-aged children. Because the treatment is dosed according to body weight, dose determination by scales poses operational challenges in community-based mass treatment campaigns. This study assessed the performance of the Pediatric Advanced Weight Prediction in the Emergency Room Extra-Long Mid-Arm Circumference (PAWPER XL-MAC) tape for weight estimation during mass drug administration in Uganda and Cote d'Ivoire. METHODS: A mixed-methods study evaluated feasibility in terms of accuracy, reliability and acceptability of the PAWPER XL-MAC tape across delivery platforms and users between March 2025 and March 2026. Accuracy metrics comprised (1) the mean relative difference and mean absolute relative difference between predicted (tape) and observed (scale) weight and (2) the proportion of estimates within 10% (PW10) and 20% (PW20) of observed weight. Reliability was evaluated by calculating the intraclass-correlation coefficient (ICC). User experiences were collected through observations, questionnaires, focus group discussions and in-depth interviews. RESULTS: In Uganda (n = 3369), mean absolute differences were 11.0-11.1%; PW10 60.2-61.0%. In Cote d'Ivoire (n = 1249), accuracy was higher (6.8-7.7%; PW10 72.4-78.2%). Reliability was high between users and countries (ICCs >/= 0.84). Sufficient time for practical training was essential to achieve solid performance. With continued use, an increase in confidence, efficiency, and accuracy was observed. Qualitative results indicated strong acceptability and practical advantages amongst users. CONCLUSIONS: This is the first study to demonstrate that the PAWPER XL-MAC tape offers reliable, accurate, and acceptable weight estimation for community-based interventions, supporting its use in routine child healthcare and public health programmes. Trial registration ClinicalTrials.gov ID NCT06698510, date of registration: 21.11.2024. CI - (c) 2026. The Author(s). FAU - Monnier, Nora AU - Monnier N AUID- ORCID: 0000-0001-5140-8549 AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. nora.monnier@swisstph.ch. AD - University of Basel, Basel, Switzerland. nora.monnier@swisstph.ch. AD - Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123, Allschwil, Switzerland. nora.monnier@swisstph.ch. FAU - Beinamaryo, Prudence AU - Beinamaryo P AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Wells, Mike AU - Wells M AD - Division of Emergency Medicine, University of the Witwatersrand, Johannesburg, South Africa. AD - Jackson Memorial Hospital, Miami, FL, USA. FAU - Akoa, Agathe AU - Akoa A AD - Programme National de Nutrition, Ministere de la Sante, de l'Hygiene et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Aritnaitwe, Moses AU - Aritnaitwe M AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Barth-Jaeggi, Tanja AU - Barth-Jaeggi T AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Bassa, Fidele K AU - Bassa FK AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - Burrill, Jenny AU - Burrill J AD - Unlimit Health, London, UK. FAU - Coulibaly, Gaoussou AU - Coulibaly G AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - Diakite, Nana R AU - Diakite NR AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - Dje, Norbert N AU - Dje NN AD - Programme National de Lutte Contre les Maladies Tropicales Negligees a Chimiotherapie Preventive, Ministere de la Sante, de l'Hygiene Publique et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Gnahore, Alexise D AU - Gnahore AD AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Hattendorf, Jan AU - Hattendorf J AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Hurlimann, Eveline AU - Hurlimann E AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Kouame, Rene O AU - Kouame RO AD - Programme National de Nutrition, Ministere de la Sante, de l'Hygiene et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Kouamin, Alain C AU - Kouamin AC AD - Programme National de Lutte Contre les Maladies Tropicales Negligees a Chimiotherapie Preventive, Ministere de la Sante, de l'Hygiene Publique et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Kyarisiima, Hilda AU - Kyarisiima H AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Lange, Isabelle L AU - Lange IL AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. FAU - Lavry, Suzanne Lobohon AU - Lavry SL AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Nabatte, Betty AU - Nabatte B AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Neema, Stella AU - Neema S AD - Department of Sociology and Anthropology, Makerere University, Kampala, Uganda. FAU - N'Goran, Eliezer K AU - N'Goran EK AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - N'Goran, Hahyat R AU - N'Goran HR AD - Programme National de Lutte Contre les Maladies Tropicales Negligees a Chimiotherapie Preventive, Ministere de la Sante, de l'Hygiene Publique et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Ohouo, Ulrich AU - Ohouo U AD - Programme National de Nutrition, Ministere de la Sante, de l'Hygiene et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Preston, Ashley AU - Preston A AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Roth, Laura F AU - Roth LF AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Sehi Bi, Tra J AU - Sehi Bi TJ AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Verhoeven, Dianne AU - Verhoeven D AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Winkler, Andrea S AU - Winkler AS AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. AD - Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway. FAU - Toh, Alain AU - Toh A AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Steinmann, Peter AU - Steinmann P AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Ouattara, Mamadou AU - Ouattara M AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. CN - Pediatric Praziquantel Consortium LA - eng SI - ClinicalTrials.gov/NCT06698510 GR - G2020-102/Global Health Innovation Technology Fund/ GR - RIA2019IR-2895./EDCTP/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20261012 PL - England TA - Infect Dis Poverty JT - Infectious diseases of poverty JID - 101606645 RN - 0 (Anthelmintics) RN - 6490C9U457 (Praziquantel) SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Anthelmintics/administration & dosage MH - *Body Weight MH - Cote d'Ivoire/epidemiology MH - Feasibility Studies MH - *Mass Drug Administration MH - *Praziquantel/administration & dosage/therapeutic use MH - Reproducibility of Results MH - *Schistosomiasis/prevention & control/drug therapy MH - Uganda/epidemiology PMC - PMC13660070 OTO - NOTNLM OT - Arpraziquantel OT - Child health OT - Implementation research OT - Neglected tropical diseases OT - Pediatric drug dosing OT - Preschool-aged children OT - Schistosomiasis OT - Weight estimation COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki and scientific standards for research involving human participants. The study in Uganda was approved by the Ugandan National Council for Science and Technology (UNCST, Ref: HS5146ES), the Vector Control Division Research Ethics Committee (VCDR-2024-60) and the Ethics Committee Northwest and Central Switzerland (EKNZ, AO_2024-10-00103). Authorization to conduct research in Bugiri and Hoima Districts was given by the local governments in each district. The study in Cote d'Ivoire was approved by the National Ethics Committee of Cote d'Ivoire (Comite National d'Ethique des Sciences de la Vie et de la Sante CNESVS, N/Ref: 00215-25/MSHPCMU/CNESVS-km) and EKNZ (AO_2025-00121). The social science study for pilot implementation in Uganda was approved by the Ethics Committee of the Technical University of Munich (TUM), University Hospital (TUM, 2024-394-S-CB), Germany, the Makerere University School of Social Science Research Ethics Committee (MAKSSREC 07.2024.766) and the UNCST (SS3420ES). The social science study in the large-scale study distribution in Cote d'Ivoire was approved by the Ethics Committee of TUM (2025-623-S-CT) and by the CNESVS (N/Ref: 00188-25/MSHPCMU/CNESVS-km) of Cote d'Ivoire. All participants, or the parents/legal guardians of minors, provided informed consent prior to enrolment. No biological samples were collected. Consent for publication: Not applicable. Patient and public involvement: Patients or the public were not involved in the design, or conduct, or reporting, or dissemination plans of our research. Competing interests: The authors declare no competing interests. EDAT- 2026/10/13 05:31 MHDA- 2026/10/13 05:32 PMCR- 2026/10/12 CRDT- 2026/10/13 00:47 PHST- 2026/06/02 00:00 [received] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/13 05:32 [medline] PHST- 2026/10/13 05:31 [pubmed] PHST- 2026/10/13 00:47 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - 10.1186/s40249-026-01507-9 [pii] AID - 1507 [pii] AID - 10.1186/s40249-026-01507-9 [doi] PST - epublish SO - Infect Dis Poverty. 2026 Oct 12;15(1):108. doi: 10.1186/s40249-026-01507-9. PMID- 42864118 OWN - NLM STAT- In-Process LR - 20261016 IS - 2755-9734 (Electronic) IS - 2755-9734 (Linking) VI - 29 IP - 1 DP - 2026 Oct 12 TI - Psychological and anthropometric outcomes in preschool children exposed to antenatal maternal obesity: modelling of early life risk factors. LID - 10.1136/bmjment-2026-302738 [doi] LID - e302738 AB - BACKGROUND: Maternal obesity is associated with increased risk of adverse neurodevelopmental outcomes and obesity in offspring, yet their comorbidity among preschoolers and underlying mechanisms remain unclear. OBJECTIVE: To examine associations between maternal obesity in pregnancy and offspring preschool psychopathology, focusing on clinical and biological pathways. METHODS: In a cohort of 462 women with obesity in pregnancy (body mass index (BMI) >/=30 kg/m(2)) from the UK Pregnancies Better Eating and Activity Trial, followed up with their children at 3-4 years postpartum (49% boys), structural equation models assessed effects of antenatal exposures (measured at three visits) on child risk of psychopathology: maternal inflammation (by interleukin-6), glycaemia (by random glucose or gestational diabetes diagnosis), placental function (by placental growth factor) and depressive symptoms. Child outcomes were derived from the Strengths and Difficulties Questionnaire scores and psychological phenotypes from latent class analysis (LCA). Child adiposity and eating behaviours were compared across phenotypes. FINDINGS: High-risk of psychopathology was identified in 11.3% of children (boys 14.7%, girls 8%). Higher antenatal maternal depression and lower placental function predicted increased risk of psychopathology, while inflammation and glycaemia were not associated (R(2)=44.5%). LCA identified externalising (8%) and internalising (4.1%) phenotypes. An externalising phenotype was associated with higher BMI, weight-for-age z-scores and waist circumference; both phenotypes showed greater food fussiness than well-adjusted children. CONCLUSIONS: One in 10 children of women with obesity showed early risk of psychopathology, which was linked to adiposity. Antenatal maternal depression emerged as the primary risk factor, with a novel role for placental dysfunction. CLINICAL IMPLICATION: Screening for maternal depression and placental function in pregnancies affected by obesity may help reduce adverse neurodevelopmental and metabolic outcomes in offspring. FAU - Sigurdardottir, Julie AU - Sigurdardottir J AUID- ORCID: 0000-0002-7328-648X AD - Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK julie.nihouarn@kcl.ac.uk. FAU - Dalrymple, Kathryn AU - Dalrymple K AD - Department of Nutritional Sciences, School of Life Course and Population Health Sciences, King's College London, London, UK. FAU - Rutherford, Mary AU - Rutherford M AD - Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. FAU - Poston, Lucilla AU - Poston L AD - Department of Women and Children's Health, School of Life Course and Population Health Sciences, King's College London, London, UK. CN - UPBEAT Consortium LA - eng PT - Journal Article DEP - 20261012 PL - England TA - BMJ Ment Health JT - BMJ mental health JID - 9918521385306676 SB - IM PMC - PMC13662093 OTO - NOTNLM OT - Attention Deficit and Disruptive Behavior Disorders OT - Child Behavior Disorders OT - Feeding and Eating Disorders of Childhood OT - Psychometrics OT - Psychopathology COIS- Competing interests: None declared. FIR - Poston, Lucilla IR - Poston L FIR - Shennan, Andrew IR - Shennan A FIR - Briley, Annette IR - Briley A FIR - Singh, Claire IR - Singh C FIR - Seed, Paul IR - Seed P FIR - Sandall, Jane IR - Sandall J FIR - Sanders, Thomas IR - Sanders T FIR - Patel, Nashita IR - Patel N FIR - Flynn, Angela IR - Flynn A FIR - Badger, Shirlene IR - Badger S FIR - Barr, Suzanne IR - Barr S FIR - Holmes, Bridget IR - Holmes B FIR - Goff, Louise IR - Goff L FIR - Hunt, Clare IR - Hunt C FIR - Filmer, Judy IR - Filmer J FIR - Fetherstone, Jeni IR - Fetherstone J FIR - Scholtz, Laura IR - Scholtz L FIR - Tarft, Hayley IR - Tarft H FIR - Lucas, Anna IR - Lucas A FIR - Tekletdadik, Tsigerada IR - Tekletdadik T FIR - Ricketts, Deborah IR - Ricketts D FIR - Gill, Carolyn IR - Gill C FIR - Ignatian, Alex Seroge IR - Ignatian AS FIR - Boylen, Catherine IR - Boylen C FIR - Adegoke, Funso IR - Adegoke F FIR - Lawley, Elodie IR - Lawley E FIR - Butler, James IR - Butler J FIR - Maitland, Rahat IR - Maitland R FIR - Vieira, Matias IR - Vieira M FIR - Pasupathy, Dharmintra IR - Pasupathy D FIR - Goff, Louise IR - Goff L FIR - Oteng-Ntim, Eugene IR - Oteng-Ntim E FIR - Khazaezadeh, Nina IR - Khazaezadeh N FIR - Demilew, Jill IR - Demilew J FIR - O'Connor, Sile IR - O'Connor S FIR - Evans, Yvonne IR - Evans Y FIR - O'Donnell, Susan IR - O'Donnell S FIR - Llera, Ari Dela IR - Llera AD FIR - Gutzwiller, Georgina IR - Gutzwiller G FIR - Hagg, Linda IR - Hagg L FIR - Robson, Stephen IR - Robson S FIR - Bell, Ruth IR - Bell R FIR - Hayes, Louise IR - Hayes L FIR - Kinnunen, Tarja IR - Kinnunen T FIR - McParlin, Catherine IR - McParlin C FIR - Miller, Nicola IR - Miller N FIR - Kimber, Alison IR - Kimber A FIR - Riches, Jill IR - Riches J FIR - Allen, Carly IR - Allen C FIR - Boag, Claire IR - Boag C FIR - Campbell, Fiona IR - Campbell F FIR - Fenn, Andrea IR - Fenn A FIR - Ritson, Sarah IR - Ritson S FIR - Rennie, Alison IR - Rennie A FIR - Durkin, Robin IR - Durkin R FIR - Gills, Gayle IR - Gills G FIR - Carr, Roger IR - Carr R FIR - Nelson, Scott IR - Nelson S FIR - Sattar, Naveed IR - Sattar N FIR - McSorley, Therese IR - McSorley T FIR - Alba, Hilary IR - Alba H FIR - Paterson, Kirsteen IR - Paterson K FIR - Johnston, Janet IR - Johnston J FIR - Clements, Suzanne IR - Clements S FIR - Fernon, Maxine IR - Fernon M FIR - Bett, Savannah IR - Bett S FIR - Rooney, Laura IR - Rooney L FIR - Miller, Sinead IR - Miller S FIR - Welsh, Paul IR - Welsh P FIR - Cherry, Lynn IR - Cherry L FIR - Whitworth, Melissa IR - Whitworth M FIR - Patterson, Natalie IR - Patterson N FIR - Lee, Sarah IR - Lee S FIR - Grimshaw, Rachel IR - Grimshaw R FIR - Hughes, Christine IR - Hughes C FIR - Brown, Jay IR - Brown J FIR - Hinshaw, Kim IR - Hinshaw K FIR - Campbell, Gillian IR - Campbell G FIR - Knight, Joanne IR - Knight J FIR - Farrar, Diane IR - Farrar D FIR - Jones, Vicky IR - Jones V FIR - Butterfield, Gillian IR - Butterfield G FIR - Syson, Jennifer IR - Syson J FIR - Eadle, Jennifer IR - Eadle J FIR - Wood, Dawn IR - Wood D FIR - Todd, Merane IR - Todd M FIR - Khalil, Asma IR - Khalil A FIR - Brown, Deborah IR - Brown D FIR - Fernandez, Paola IR - Fernandez P FIR - Cousins, Emma IR - Cousins E FIR - Smith, Melody IR - Smith M FIR - Wardle, Jane IR - Wardle J FIR - Croker, Helen IR - Croker H FIR - Broomfield, Laura IR - Broomfield L FIR - Concern, Weight IR - Concern W FIR - Godfrey, Keith IR - Godfrey K FIR - Robinson, Sian IR - Robinson S FIR - Canadine, Sarah IR - Canadine S FIR - Greenwood, Lynne IR - Greenwood L EDAT- 2026/10/13 00:16 MHDA- 2026/10/13 00:16 PMCR- 2026/10/12 CRDT- 2026/10/12 21:42 PHST- 2026/03/31 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/13 00:16 [medline] PHST- 2026/10/13 00:16 [pubmed] PHST- 2026/10/12 21:42 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - bmjment-2026-302738 [pii] AID - 10.1136/bmjment-2026-302738 [doi] PST - epublish SO - BMJ Ment Health. 2026 Oct 12;29(1):e302738. doi: 10.1136/bmjment-2026-302738. PMID- 42863993 OWN - NLM STAT- Publisher LR - 20261012 IS - 1349-9092 (Electronic) IS - 0917-5040 (Linking) DP - 2026 Oct 9 TI - Relative Validity of Nutrient and Food Group Intakes Estimated From the Brief-type Self-administered Dietary History Questionnaire for Japanese Preschool Children Aged 3-6 Years (BDHQ3y). LID - 10.2188/jea.JE20250707 [doi] AB - BACKGROUND: To evaluate the relative validity of nutrient and food group intakes estimated using the brief-type self-administered Diet History Questionnaire for Japanese preschool children aged 3-6 years (BDHQ3y). METHODS: This study included 500 children (253 boys and 247 girls) aged 3-6 years recruited from 32 prefectures in Japan. Guardians completed the BDHQ3y to report their child's dietary intake over the previous month and then 8-day weighed dietary records (DRs) over a year (2 days per season). From the BDHQ3y and DRs, energy-adjusted intakes of 44 nutrients and 26 food groups were estimated based on the density method. RESULTS: Percentage differences in median intakes were within 10% for 26 nutrients (most energy-providing nutrients and several vitamins and minerals) and three food groups (cereals, fish/shellfish and milk/dairy products). The median Spearman's rank correlation coefficients were 0.31 (interquartile range [IQR], 0.23-0.40) for nutrients and 0.32 (IQR, 0.23-0.41) for food groups. Correlations exceeded 0.40 for 11 nutrients (eg, added sugar, dietary fiber and calcium) and nine food groups (eg, vegetables, fruits and milk/dairy products). Bland-Altman plots showed wide limits of agreement, with overestimation of intakes of protein, fats, carbohydrates, fruits, and milk/dairy products, as well as underestimation of intake of vegetables at higher intake levels. Similar findings were made when boys and girls were analyzed separately. CONCLUSION: The BDHQ3y has the potential to monitor population-level intakes of a range of nutrients. However, its utility for ranking individuals and assessing individual-level intake remains limited, requiring cautious interpretation and application. FAU - Tajima, Ryoko AU - Tajima R AUID- ORCID: 0000-0002-7799-3958 AD - Department of Nutritional Epidemiology and Behavioral Nutrition, Graduate School of Medicine, the University of Tokyo. FAU - Okubo, Hitomi AU - Okubo H AD - Department of Nutritional Epidemiology and Behavioral Nutrition, Graduate School of Medicine, the University of Tokyo. FAU - Shinozaki, Nana AU - Shinozaki N AD - Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo. FAU - Masayasu, Shizuko AU - Masayasu S AD - Ikurien-naka. FAU - Sasaki, Satoshi AU - Sasaki S AD - Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo. FAU - Murakami, Kentaro AU - Murakami K AD - Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo. LA - eng PT - Journal Article DEP - 20261009 PL - Japan TA - J Epidemiol JT - Journal of epidemiology JID - 9607688 SB - IM OTO - NOTNLM OT - Japanese OT - diet history questionnaire OT - food and nutrient intake OT - preschool children OT - relative validity EDAT- 2026/10/13 00:16 MHDA- 2026/10/13 00:16 CRDT- 2026/10/12 21:23 PHST- 2026/10/13 00:16 [medline] PHST- 2026/10/13 00:16 [pubmed] PHST- 2026/10/12 21:23 [entrez] AID - 10.2188/jea.JE20250707 [doi] PST - aheadofprint SO - J Epidemiol. 2026 Oct 9. doi: 10.2188/jea.JE20250707. PMID- 42863668 OWN - NLM STAT- Publisher LR - 20261016 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 76 DP - 2026 Oct 12 TI - Anabolic responsiveness in critically ill children: A narrative review and conceptual perspective on nutrient utilization and muscle response. PG - 105189 LID - S2405-4577(26)02286-2 [pii] LID - 10.1016/j.clnesp.2026.105189 [doi] AB - Critical illness alters energy metabolism, substrate use, and protein turnover in children, while skeletal muscle loss may continue despite apparently adequate energy and protein delivery. Nutritional adequacy may depend not only on nutrient delivery but also on how effectively nutrients are utilized to preserve muscle and support anabolic responsiveness. This hypothesis-generating narrative review synthesizes evidence on metabolic alterations and anabolic responsiveness in critically ill children, focusing on indirect calorimetry, respiratory quotient (RQ), non-protein RQ (npRQ), nitrogen balance, and quadriceps and diaphragm ultrasound. PubMed/MEDLINE was searched from inception to July 2026, prioritizing pediatric evidence and incorporating adult studies when pediatric data were insufficient. Indirect calorimetry remains the reference bedside method for measuring resting energy expenditure but cannot determine whether nutrients are incorporated into skeletal muscle protein. RQ and npRQ provide information on whole-body substrate oxidation but lack validated pediatric thresholds. Nitrogen balance estimates whole-body protein retention or loss but does not directly reflect skeletal muscle protein balance. Serial ultrasound can track regional muscle changes, although quadriceps and diaphragm measurements reflect different physiological influences. Pediatric studies demonstrate early peripheral muscle loss, while direct measurements of muscle protein synthesis and breakdown remain limited. No routinely available bedside method can directly assess anabolic responsiveness or confirm anabolic resistance. Integrating metabolic measurements with serial muscle assessment may identify mismatches between nutrient delivery and tissue response but remains hypothesis-generating. Prospective studies incorporating direct protein kinetics are needed to determine when anabolic responsiveness is restored and whether this can guide nutritional and rehabilitation strategies. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Giannakopoulou, Ioulia AU - Giannakopoulou I AD - Pediatric Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Ilia, Stavroula AU - Ilia S AD - Pediatric Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Briassoulis, George AU - Briassoulis G AD - Pediatric Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Raissaki, Maria AU - Raissaki M AD - Division of Radiology, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Kozana, Androniki AU - Kozana A AD - Division of Radiology, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Filippatos, Filippos AU - Filippatos F AD - Division of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Greece. FAU - Kakleas, Konstantinos AU - Kakleas K AD - Division of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Greece. FAU - Miliaraki, Marianna AU - Miliaraki M AD - Pediatric Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. Electronic address: mmiliaraki@uoc.gr. LA - eng PT - Journal Article PT - Review DEP - 20261012 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM OTO - NOTNLM OT - Anabolic resistance OT - Indirect calorimetry OT - Mechanical ventilation OT - Muscle ultrasound OT - Nitrogen balance OT - Pediatric intensive care COIS- Conflicts of interest The authors declare no conflicts of interest. EDAT- 2026/10/13 00:16 MHDA- 2026/10/13 00:16 CRDT- 2026/10/12 19:33 PHST- 2026/08/20 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/13 00:16 [pubmed] PHST- 2026/10/13 00:16 [medline] PHST- 2026/10/12 19:33 [entrez] AID - S2405-4577(26)02286-2 [pii] AID - 10.1016/j.clnesp.2026.105189 [doi] PST - aheadofprint SO - Clin Nutr ESPEN. 2026 Oct 12;76:105189. doi: 10.1016/j.clnesp.2026.105189. PMID- 42863632 OWN - NLM STAT- Publisher LR - 20261012 IS - 1600-6143 (Electronic) IS - 1600-6135 (Linking) DP - 2026 Oct 12 TI - First Series of Purely Robotic Liver Transplantation in Children. LID - S1600-6135(26)02810-8 [pii] LID - 10.1016/j.ajt.2026.10.007 [doi] AB - Fully robotic liver transplantation, as defined by pure robotic donor hepatectomy as well as pure robotic liver transplantation, remains underexploited in pediatric recipients because of limited abdominal space and the absence of pediatric-specific robotic systems. To our knowledge, this study reports the first series of robotic liver transplantation in pediatric recipients. Consecutive pediatric recipients that underwent robotic liver transplantation between 30 May and 9 February 2026 using the DaVinci(R)Xi Surgical System were included. Seven pediatric robotic liver transplants were performed, including 6 (85.7%) partial graft implantations fully robotic and 1 (14.3%) whole liver implant via domino transplantation, retrieved with the open approach from a separate pediatric donor and implanted robotically. Median recipient age and body mass index were 12.5 years and 17 kg/m(2), respectively. Median operation duration was 458min, median warm ischemia time 46min, and median blood loss 500 ml. Major postoperative complications (Grade>/=3a) occurred in three recipients. No graft loss or mortality occurred during follow-up with a median of 15.8 months. Purely robotic liver transplantation in pediatric recipients is feasible in centers with extensive robotic liver surgery and pediatric transplantation experience. Further studies are required to evaluate long-term outcomes and define the role of robotic transplantation in pediatric patients. CI - Copyright (c) 2026 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Broering, Dieter C AU - Broering DC AD - Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research, Centre, Riyadh, Saudi Arabia; Faculty of Medicine, Alfaisal University, Riyadh, Saudi Arabia. Electronic address: broering@me.com. FAU - Rescigno, Luigi AU - Rescigno L AD - Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research, Centre, Riyadh, Saudi Arabia. FAU - Elsheikh, Yasser AU - Elsheikh Y AD - Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research, Centre, Riyadh, Saudi Arabia. FAU - Takidou, Sonia AU - Takidou S AD - Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research, Centre, Riyadh, Saudi Arabia. FAU - Shagrani, Mohammad AU - Shagrani M AD - Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research, Centre, Riyadh, Saudi Arabia; Faculty of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Marcos, Amadeo AU - Marcos A AD - Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research, Centre, Riyadh, Saudi Arabia. FAU - Malago, Massimo AU - Malago M AD - Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research, Centre, Riyadh, Saudi Arabia. FAU - Raptis, Dimitri A AU - Raptis DA AD - Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research, Centre, Riyadh, Saudi Arabia; Faculty of Medicine, Alfaisal University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20261012 PL - United States TA - Am J Transplant JT - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JID - 100968638 SB - IM OTO - NOTNLM OT - LDLT OT - complications OT - domino transplantation OT - living donor liver transplantation OT - minimally invasive surgery OT - outcomes OT - pediatric liver transplantation OT - pediatric transplantation OT - robotic liver transplantation OT - robotic surgery COIS- Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/13 00:16 MHDA- 2026/10/13 00:16 CRDT- 2026/10/12 19:32 PHST- 2026/05/27 00:00 [received] PHST- 2026/09/08 00:00 [revised] PHST- 2026/10/01 00:00 [accepted] PHST- 2026/10/13 00:16 [medline] PHST- 2026/10/13 00:16 [pubmed] PHST- 2026/10/12 19:32 [entrez] AID - S1600-6135(26)02810-8 [pii] AID - 10.1016/j.ajt.2026.10.007 [doi] PST - aheadofprint SO - Am J Transplant. 2026 Oct 12:S1600-6135(26)02810-8. doi: 10.1016/j.ajt.2026.10.007. PMID- 42862150 OWN - NLM STAT- Publisher LR - 20261012 IS - 0272-9490 (Print) IS - 0272-9490 (Linking) DP - 2026 Oct 12 TI - Lifestyle Documentation in Therapy Evaluations for Autistic Children: A Lexicon-Based Analysis of Electronic Health Records. PG - 19437676261493019 LID - 10.1177/19437676261493019 [doi] AB - BackgroundWhole person health (WPH) is a multidimensional construct encompassing, physical, and mental health along with relational constructs such as social health that are deeply tied to well-being. Autistic individuals report an overall lower quality of life, but the extent to which these issues are addressed during therapy evaluations has not been examined systematically.MethodologyIn this retrospective, cross-sectional study, we employ a rule-based NLP/lexicon-based approach to examine the areas of focus of therapy evaluations documented by occupational therapy, physical therapy (PT), and speech-language pathology (SLP) professionals. Using electronic health records for children aged 2 to 18 diagnosed with autism spectrum disorder (ASD) (n = 5619 evaluation reports of n = 2021 unique patients), we classified health records based on the domains addressed.ResultsAcross notes, nutrition had the highest average degree of documentation (M = 2.14), compared to activity (M = 0.91), followed by wellness (M = 0.66), and sleep (M = 0.39). In occupational therapy, wellness was the most common (77.62% of notes), followed by physical activity (76.49% of notes), nutrition management (73.33% of notes), and sleep (34.97% of notes). The overall area under the curve (AUC) from the receiver operating characteristic analysis is 0.89.ConclusionsWhile it is encouraging that most evaluations addressed nutrition or physical activity, the near absence of attention to sleep represents a critical gap in care. Given sleep's foundational role in overall health and daily functioning, its omission is particularly concerning. Occupational therapists and interdisciplinary rehabilitation teams should more deliberately integrate WPH frameworks into their evaluations. FAU - Dallman, Aaron R AU - Dallman AR AUID- ORCID: 0000-0001-6975-5581 AD - Department of Rehabilitation and Movement Sciences, Rutgers Health School of Health Professions, New Brunswick, USA. RINGGOLD: 242612 FAU - Santucci, Gregory AU - Santucci G AD - Children's Specialized Hospital, New Brunswick, USA. RINGGOLD: 507831 FAU - Lai, Diana AU - Lai D AD - Children's Specialized Hospital, New Brunswick, USA. RINGGOLD: 507831 FAU - Welch, Caroline AU - Welch C AD - Department of Rehabilitation and Movement Sciences, Rutgers Health School of Health Professions, New Brunswick, USA. RINGGOLD: 242612 FAU - Jimenez, Manuel E AU - Jimenez ME AD - Children's Specialized Hospital, New Brunswick, USA. RINGGOLD: 507831 AD - Rutgers Robert Wood Johnson Medical School, New Brunswick, USA. LA - eng PT - Journal Article DEP - 20261012 PL - United States TA - Am J Occup Ther JT - The American journal of occupational therapy : official publication of the American Occupational Therapy Association JID - 7705978 SB - IM OAB - Many Autistic people face challenges that can affect their overall well-being and quality of life. In this study, we reviewed evaluation reports from Autistic children in a large health system. We looked at how these reports addressed key areas of whole-person health, including physical activity, sleep, nutrition, and overall wellness. We found that nutrition was the most addressed area, followed by physical activity, sleep, and wellness. While it is encouraging that many evaluations included nutrition and physical activity, very few addressed sleep. This is an important gap, given how essential sleep is for health and daily functioning. We believe rehabilitation clinicians should routinely ask about sleep as part of their evaluations. We also suggest that evaluation reports can be a valuable tool for identifying gaps in care and should be used more often to improve health system practices. OABL- eng OTO - NOTNLM OT - Whole person health OT - autism spectrum disorder OT - learning health system OT - pediatric occupational therapy OT - secondary data analysis EDAT- 2026/10/12 11:41 MHDA- 2026/10/12 11:41 CRDT- 2026/10/12 10:33 PHST- 2026/10/12 11:41 [medline] PHST- 2026/10/12 11:41 [pubmed] PHST- 2026/10/12 10:33 [entrez] AID - 10.1177/19437676261493019 [doi] PST - aheadofprint SO - Am J Occup Ther. 2026 Oct 12:19437676261493019. doi: 10.1177/19437676261493019. PMID- 42861918 OWN - NLM STAT- Publisher LR - 20261012 IS - 1941-9260 (Electronic) IS - 0032-5481 (Linking) DP - 2026 Oct 12 TI - Toward consensus on complementary feeding recommendations: findings from a national evidence-informed modified Delphi study in Turkiye. PG - 1-12 LID - 10.1080/00325481.2026.2745217 [doi] AB - BACKGROUND: Complementary feeding (CF) recommendations are generally based on international guidelines; however, several clinical issues remain controversial, resulting in variability in professional practice. This study aimed to develop evidence-informed expert consensus on complementary feeding recommendations and to explore the reasons underlying persistent disagreement. METHODS: In this national evidence-informed modified Delphi study in Turkiye, 58 pediatricians working in Social Pediatrics participated in the first round and evaluated 53 statements using a five-point Likert scale. Statements not reaching consensus were revised based on participants' comments and reevaluated in a second round. Thirteen unresolved statements underwent a third round involving evidence presentation and structured online discussion with 23 participants; 22 subsequently completed the final re-rating. Audio-recorded discussions and written comments were analyzed using reflexive thematic analysis in MAXQDA Analytics Pro 24. RESULTS: Consensus was achieved for most recommendations regarding the timing of CF, developmental readiness, responsive feeding, and several feeding practices. Persistent disagreement remained for recommendations concerning formula-fed infants, infants with poor weight gain, preterm infants, baby-led weaning (BLW), vegan CF, bottle use, and selected allergy-related practices. Qualitative analysis generated five overarching themes: (1) individualization beyond fixed age thresholds; (2) balancing nutritional priorities with developmental safety and feasibility; (3) risk-stratified introduction of allergenic foods; (4) conditional rather than universal acceptance of BLW; and (5) ethical and clinical tensions surrounding vegan CF. Experts generally agreed on the underlying scientific principles but emphasized that recommendations should incorporate developmental readiness, clinical judgment, family circumstances, cultural context, and implementation feasibility rather than relying on rigid or universal recommendations. CONCLUSIONS: Integration of quantitative Delphi findings with qualitative thematic analysis revealed that non-consensus primarily stemmed from the practical nuances of clinical execution and contextual adaptation, rather than a fundamental skepticism toward the underlying scientific data. These findings provide an evidence-informed foundation for developing context-sensitive CF recommendations for clinical practice. FAU - Yalcin, Siddika Songul AU - Yalcin SS AUID- ORCID: 0000-0001-9061-4281 AD - Department of Pediatrics, Division of Social Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkiye. FAU - Ozboru Askan, Oyku AU - Ozboru Askan O AUID- ORCID: 0000-0002-4139-5497 AD - Faculty of Medicine, Department of Pediatrics, Istanbul Atlas University, Istanbul, Turkiye. FAU - Barutcu, Adnan AU - Barutcu A AUID- ORCID: 0000-0001-8930-1122 AD - Department of Pediatrics, Division of Social Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkiye. FAU - Almis, Habip AU - Almis H AUID- ORCID: 0000-0001-9327-4876 AD - Sincan Training and Research Hospital, Department of Pediatrics, Division of Social Pediatrics, University of Health Sciences, Ankara, Turkiye. FAU - Orun, Emel AU - Orun E AUID- ORCID: 0000-0002-7596-5603 AD - Etlik City Hospital, Department of Pediatrics, Division of Social Pediatrics, University of Health Sciences, Ankara, Turkiye. FAU - Camurdan, Aysu Duyan AU - Camurdan AD AUID- ORCID: 0000-0001-8384-7423 AD - Department of Social Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20261012 PL - England TA - Postgrad Med JT - Postgraduate medicine JID - 0401147 SB - IM OTO - NOTNLM OT - Complementary feeding OT - Delphi study OT - baby-led weaning OT - consensus OT - food allergy OT - thematic analysis OT - vegan diet EDAT- 2026/10/12 11:41 MHDA- 2026/10/12 11:41 CRDT- 2026/10/12 08:35 PHST- 2026/10/12 11:41 [medline] PHST- 2026/10/12 11:41 [pubmed] PHST- 2026/10/12 08:35 [entrez] AID - 10.1080/00325481.2026.2745217 [doi] PST - aheadofprint SO - Postgrad Med. 2026 Oct 12:1-12. doi: 10.1080/00325481.2026.2745217. PMID- 42861858 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261023 IS - 1552-4604 (Electronic) IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 66 IP - 10 DP - 2026 Oct TI - Development and Evaluation of a Population Pharmacokinetic Model for High-Dose Methotrexate in Japanese Pediatric Patients with Acute Lymphoblastic Leukemia. PG - e70310 LID - 10.1002/jcph.70310 [doi] LID - e70310 AB - Methotrexate is a key chemotherapeutic agent for treating pediatric acute lymphoblastic leukemia (ALL); however, its pharmacokinetics exhibit substantial inter-individual variability. Population pharmacokinetic (PPK) models have identified body weight and renal function as major determinants of methotrexate clearance. Nonetheless, the optimal PPK model for Japanese pediatric patients, considering hydration status, has not yet been established. This study aimed to develop a PPK model of high-dose methotrexate specifically for Japanese pediatric patients with ALL. A retrospective PPK analysis was performed in pediatric patients with ALL, who were treated with high-dose methotrexate at the Tokyo Medical and Dental University Hospital. Data from 38 patients (504 methotrexate concentrations; 27 for model development and 11 for validation) were analyzed using a two-compartment model in NONMEM. Predictive performances of the newly developed and previously published models were assessed using the validation dataset. In the final model, clearance was described as a function of body surface area and hydration volume rate per body surface area (HYDR), whereas intercompartmental clearance was associated with age and HYDR. Evaluation using the validation dataset showed that the developed model had the best predictive performance among the evaluated models (median prediction error, 1.79%; median absolute prediction error, 13.3%; percentage of predictions with an absolute prediction error 69% cell viability at 1000 mug mL(-1) for curry leaves and coriander formulations. Tablets exhibited satisfactory pharmaceutical parameters including low friability (< 0.3%), uniform weight (1.84-2.01 g), and rapid disintegration (121-128 s). CONCLUSION: The developed iron-fortified chutney tablets reconstitute easily into chutney as a ready-to-use (RTU) product, combining nutritional value, and enhanced iron bioavailability. These findings establish the feasibility of transforming traditional food matrices into standardized iron-fortified tablets, offering a dietary supplement approach for addressing micronutrient deficiencies in vulnerable populations through indigenous food-based interventions. (c) 2026 Society of Chemical Industry. CI - (c) 2026 Society of Chemical Industry. FAU - Krishna, Ram AU - Krishna R AUID- ORCID: 0009-0006-6482-3550 AD - Department of Food Engineering and Technology, Sant Longowal Institute of Engineering and Technology, Longowal, India. FAU - Prasad, Kamlesh AU - Prasad K AUID- ORCID: 0000-0001-7086-9391 AD - Department of Food Engineering and Technology, Sant Longowal Institute of Engineering and Technology, Longowal, India. LA - eng PT - Journal Article DEP - 20261011 PL - England TA - J Sci Food Agric JT - Journal of the science of food and agriculture JID - 0376334 SB - IM OTO - NOTNLM OT - cytotoxicity OT - in vitro bioavailability OT - instant chutney tablet OT - iron fortification OT - morphological properties EDAT- 2026/10/12 05:32 MHDA- 2026/10/12 05:32 CRDT- 2026/10/12 01:24 PHST- 2026/06/15 00:00 [revised] PHST- 2026/01/14 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/12 05:32 [medline] PHST- 2026/10/12 05:32 [pubmed] PHST- 2026/10/12 01:24 [entrez] AID - 10.1002/jsfa.71166 [doi] PST - aheadofprint SO - J Sci Food Agric. 2026 Oct 11. doi: 10.1002/jsfa.71166. PMID- 42859602 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261011 LR - 20261012 IS - 1178-2390 (Print) IS - 1178-2390 (Electronic) IS - 1178-2390 (Linking) VI - 19 DP - 2026 TI - Development and Expert Validation of a Hospital-to-Home Care Pathway for Preterm Infants in Indonesia: A Qualitative and Delphi Study. PG - 639379 LID - 10.2147/JMDH.S639379 [doi] LID - 639379 AB - PURPOSE: The transition of preterm infants from hospital to home requires coordinated care across hospital, primary care, community, and family settings. This study aimed to develop and validate a Hospital-to-Home Care Pathway for preterm infants in Indonesia. PATIENTS AND METHODS: A sequential exploratory qualitative-Delphi consensus design was used. This study was conducted in Bandung, West Java, Indonesia, from May 2025 to November 2025. Stage 1 involved 70 stakeholders, including mothers, healthcare providers, community health volunteers (cadres), managers, hospital leaders, and health office representatives. Data were collected through focus group discussions, in-depth interviews, observations, and document review and analyzed using inductive thematic analysis. Stage 2 used three Delphi rounds with seven experts to refine and validate the pathway. RESULTS: Stage 1 identified fragmentation across care settings beyond parental knowledge gaps. Synthesized findings yielded six pathway needs: parental readiness, information continuity, hospital-community coordination, defined roles for community health volunteers and primary care providers, community follow-up, and monitoring, evaluation, and referral feedback. Stage 2 confirmed expert consensus. Round 1 agreement ranged from 85.7% to 100%. In Round 2, item-level content validity ranged from 0.86 to 1.00, with scale-level content validity index based on average agreement (S-CVI/Ave) = 0.99 and scale-level content validity index based on universal agreement (S-CVI/UA) = 0.90. Round 3 confirmed final consensus and response stability. The final pathway comprised a visual care flow and an operational table specifying care settings, components, activities, responsible providers, and documents. CONCLUSION: This study produced an expert-validated Hospital-to-Home Care Pathway for preterm infants in Indonesia. The pathway integrates discharge planning, community follow-up, family education, documentation, and referral feedback. As a pre-implementation output, the pathway should be evaluated further through feasibility, acceptability, fidelity, and effectiveness testing before claims about clinical or health-system impact are made. CI - (c) 2026 Kamila et al. FAU - Kamila, Lia AU - Kamila L AUID- ORCID: 0009-0004-3153-3659 AD - Doctoral Study Program in Medical Science, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia. AD - Faculty of Midwifery, Institut Kesehatan Rajawali, Bandung, West Java, Indonesia. FAU - Susanti, Ari Indra AU - Susanti AI AUID- ORCID: 0000-0001-6638-5992 AD - Midwifery Program, Vocational School, Universitas Padjadjaran, Sumedang, West Java, Indonesia. FAU - Wiwaha, Guswan AU - Wiwaha G AUID- ORCID: 0000-0002-2514-7493 AD - Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia. FAU - Hilmanto, Dany AU - Hilmanto D AUID- ORCID: 0000-0003-3684-4144 AD - Department of Pediatrics, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia. LA - eng PT - Journal Article DEP - 20261004 PL - New Zealand TA - J Multidiscip Healthc JT - Journal of multidisciplinary healthcare JID - 101512691 PMC - PMC13652962 OAB - Why was this study done? Preterm infants often need continued support after hospital discharge, while parents may feel unprepared to provide care at home. In Indonesia, post-discharge care involves hospitals, primary healthcare centers, community health posts, community health volunteers, and families, but communication and follow-up are not always well coordinated. This study aimed to develop a structured pathway to support the transition of preterm infants from hospital to home. What did the researchers do? The researchers collected data from 70 stakeholders, including mothers, healthcare providers, community health volunteers, managers, hospital leaders, and health office representatives. Interviews, focus group discussions, observations, and document review were used to identify care needs and service gaps. The findings were used to develop a preliminary Hospital-to-Home Care Pathway, which was then validated through three Delphi rounds with seven experts. What did we find? The main challenge was not only whether parents had enough knowledge. The larger problem was fragmented care between hospitals, primary care, community services, and home. The final pathway includes discharge preparation, parent education, home visits, breastfeeding and nutrition support, growth and developmental monitoring, family education, documentation, and referral feedback. What does this mean? The pathway explains the sequence of care, who is responsible, when follow-up should occur, and which documents are needed. The next step is to pilot test the pathway to assess whether it can be used in routine practice, whether it is acceptable to families and healthcare providers, whether the planned activities can be carried out as intended, and what benefits it may have for infants, families, and health services. OABL- eng OTO - NOTNLM OT - community health workers OT - continuity of care OT - discharge planning OT - neonatal follow-up OT - parental readiness OT - primary healthcare COIS- The authors declare that they have no competing interests or potential conflicts of interest related to this study. EDAT- 2026/10/11 05:38 MHDA- 2026/10/11 05:39 PMCR- 2026/10/04 CRDT- 2026/10/11 04:17 PHST- 2026/07/10 00:00 [received] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/11 05:39 [medline] PHST- 2026/10/11 05:38 [pubmed] PHST- 2026/10/11 04:17 [entrez] PHST- 2026/10/04 00:00 [pmc-release] AID - 639379 [pii] AID - 10.2147/JMDH.S639379 [doi] PST - epublish SO - J Multidiscip Healthc. 2026 Oct 4;19:639379. doi: 10.2147/JMDH.S639379. eCollection 2026. PMID- 42859314 OWN - NLM STAT- MEDLINE DCOM- 20261011 LR - 20261013 IS - 1573-2649 (Electronic) IS - 0962-9343 (Linking) VI - 35 IP - 11 DP - 2026 Oct 10 TI - Multimorbidity profiles and global quality of life: a population-based latent class and structural equation modeling study. LID - 303 [pii] LID - 10.1007/s11136-026-04411-9 [doi] AB - PURPOSE: To examine whether clustered configurations of multimorbidity, functional limitation, physical activity, formal social participation, and alcohol risk are associated with global quality of life (QoL), and to evaluate the hierarchical structure of the World Health Organization Quality of Life-BREF (WHOQOL-BREF) using data from anationally representative Chilean survey. METHODS: Cross-sectional data were drawn from the 2023-2024 Chilean National Survey on Quality of Life and Health. Latent class analysis identified health-functional profiles using five categorical indicators (n = 16,469). Confirmatory factor analysis evaluated correlated four-factor and hierarchical second-order representations of the WHOQOL-BREF (n = 13,451). Structural equation modeling examined associations between profile membership, sociodemographic characteristics, and global QoL (n = 13,016). Analyses incorporated calibrated sampling weights, with design-basedinference accounting for the stratified and clustered survey design. RESULTS: A three-class solution comprising lower-burden, intermediate-burden, and higher-burden profiles was retained. Profiles were most clearly differentiated by multimorbidity and functional limitation, whereas physical activity, social participation, and alcohol risk showed weaker or nonmonotonic differentiation. The hierarchical WHOQOL-BREF model showed comparable approximate fit to the correlated four-factor model, with strong secondorder loadings across all four QoL domains. Relative to the lower-burden profile, global QoL was lower in theintermediate-burden profile (beta = -.132, p < .001) and substantially lower in the higher-burden profile (beta = -.341, p < .001). Posterior pseudo-class sensitivity analyses preserved the direction and ordering of these associations. Educational attainment (beta = .142, p < .001) and household income (beta = .139, p < .001) were positively associated with global QoL. CONCLUSION: Global QoL was associated with graded health-functional burden and socioeconomic position. Combining person-centered health profiles with a hierarchical representation of QoL may provide a useful framework for characterizing population heterogeneity in health, functioning, and subjective quality of life. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Manriquez-Robles, Diego AU - Manriquez-Robles D AUID- ORCID: 0000-0002-6394-7854 AD - Departamento de Psicologia, Universidad de La Frontera, Temuco, Chile. dmanriquezrobles@gmail.com. AD - Department of Psychological Sciences, Rice University, Houston, USA. dmanriquezrobles@gmail.com. FAU - Roa-Castillo, Scarlett AU - Roa-Castillo S AD - Department of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, USA. FAU - Aedo, Melisa AU - Aedo M AD - Departamento de Psicologia, Universidad Catolica de Temuco, Temuco, Chile. FAU - Henriquez-Valenzuela, Felipe AU - Henriquez-Valenzuela F AD - Departamento de Salud, Universidad de Los Lagos, Osorno, Chile. FAU - Alvarado, Ruben AU - Alvarado R AD - Departamento de Salud Publica, Universidad de Valparaiso, Valparaiso, Chile. LA - eng GR - 56220079/Agencia Nacional de Investigacion y Desarrollo , Chile/ PT - Journal Article DEP - 20261010 PL - Netherlands TA - Qual Life Res JT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JID - 9210257 SB - IM MH - Humans MH - *Quality of Life/psychology MH - Female MH - *Multimorbidity MH - Cross-Sectional Studies MH - Male MH - Latent Class Analysis MH - Chile MH - Adult MH - Middle Aged MH - Social Participation MH - Exercise MH - Aged MH - Surveys and Questionnaires MH - Socioeconomic Factors MH - Young Adult MH - Factor Analysis, Statistical MH - Adolescent OAB - Quality of life reflects not only the presence of disease, but also how people function in daily life, participate in society, and experience their physical, psychological, social, and environmental circumstances. Most research examines these characteristics separately, even though they may occur together. Using nationally representative data from Chile, this study identified patterns based on multimorbidity, functional limitation, physical activity, formal social participation, and alcohol risk, and examined how these patterns were related to overall quality of life.Three overlapping health-functional profiles were identified: lower-burden, intermediate-burden, and higher-burden profiles. The clearest differences between them involved the number of chronic conditions and the severity of functional limitation, while physical activity, social participation, and alcohol risk varied less consistently. Quality of life was progressively lower across the three profiles. Compared with people in the lower-burden profile, those in the intermediate-burden profile reported lower quality of life, and those in the higher-burden profile showed the largest difference, even after accounting for income, education, age, sex, and place of residence. Higher education and household income were also associated with better quality of life. These findings suggest that considering combinations of health and functional characteristics may provide a more complete picture of population differences in quality of life than examining individual conditions separately. OABL- eng OTO - NOTNLM OT - Health inequalities OT - Latent class analysis OT - Multimorbidity OT - Quality of life OT - Structural equation modeling OT - WHOQOL-BREF COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: This study is based on secondary analysis of publicly available, anonymized data from the Chilean National Survey on Quality of Life and Health (ENCAVI). According to national regulations and institutional guidelines, ethics approval was not required. Consent to participate: Not applicable. The study uses publicly available, de-identified data, and informed consent was obtained by the original data collection agency. Consent to publish: Not applicable. No identifiable individual data are included in this study. EDAT- 2026/10/11 05:38 MHDA- 2026/10/11 05:39 CRDT- 2026/10/10 23:48 PHST- 2026/04/22 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/11 05:39 [medline] PHST- 2026/10/11 05:38 [pubmed] PHST- 2026/10/10 23:48 [entrez] AID - 10.1007/s11136-026-04411-9 [pii] AID - 10.1007/s11136-026-04411-9 [doi] PST - epublish SO - Qual Life Res. 2026 Oct 10;35(11):303. doi: 10.1007/s11136-026-04411-9. PMID- 42859262 OWN - NLM STAT- MEDLINE DCOM- 20261011 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 10 TI - Primary care and idiopathic scoliosis: an evaluation of family physicians' roles. LID - 828 [pii] LID - 10.1007/s00431-026-07484-3 [doi] AB - Idiopathic scoliosis (IS) can progress silently during growth. Early primary care detection prevents curve progression and reduces treatment burden. This study aimed to assess the role of family physicians in screening, diagnosis, counseling, and follow-up of adolescents with IS, and to evaluate primary care attributes using the Primary Care Assessment Survey (PCAS). This cross-sectional study included 150 patients with IS followed at a university orthopedics clinic in Turkiye. Data were collected via structured telephone interviews using a custom 13-item questionnaire and the validated Turkish PCAS. Descriptive statistics and bivariate parametric and non-parametric tests were used for the analysis (p < 0.05). Only 11% of participants were first diagnosed by family physicians, whereas 68% were diagnosed by orthopedic surgeons. Primary care involvement was low: scoliosis-focused examination (15%), counseling (15%), referral (15%), and exercise recommendations (19%) were infrequent. PCAS scores were highest for longitudinal continuity (79 +/- 20) and trust (63 +/- 12), and lowest for preventive services and counseling (44 +/- 35). Late-onset scoliosis was associated with significantly higher scores in comprehensive knowledge, physical care, personal approach, accessibility, and communication (p < 0.05). CONCLUSION: Most patients with IS are diagnosed outside primary care, highlighting a substantial underutilization of opportunistic screening and early clinical evaluation in primary care settings. Standardizing scoliosis screening during routine adolescent well-visits, enhancing primary care awareness and guidance, and strengthening referral pathways are crucial for enabling earlier detection, modifying disease progression, and mitigating long-term clinical burdens. WHAT IS KNOWN: * Early detection of idiopathic scoliosis (IS) through opportunistic screening prevents curve progression, avoids invasive surgeries, and reduces long-term healthcare burdens.. WHAT IS NEW: * Only 11% of IS patients are diagnosed in primary care, revealing critical gaps in screening, posture examination, and counseling despite high longitudinal trust in family physicians.. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Tukel, Filiz Yildiz AU - Tukel FY AD - Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University, Balcova, Izmir, 35330, Turkey. FAU - Come, Ogulcan AU - Come O AUID- ORCID: 0000-0002-6624-832X AD - Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University, Balcova, Izmir, 35330, Turkey. ogulcancome@gmail.com. FAU - Limnili, Gizem AU - Limnili G AD - Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University, Balcova, Izmir, 35330, Turkey. FAU - Gokdemir, Ozden AU - Gokdemir O AD - Department of Family Medicine, Faculty of Medicine, Ekonomi University, Izmir, Turkey. FAU - Ozcakar, Nilgun AU - Ozcakar N AD - Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University, Balcova, Izmir, 35330, Turkey. LA - eng PT - Journal Article DEP - 20261010 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Scoliosis/diagnosis/therapy MH - Cross-Sectional Studies MH - Female MH - *Primary Health Care/statistics & numerical data MH - Male MH - Adolescent MH - *Physician's Role MH - Surveys and Questionnaires MH - *Physicians, Family MH - Turkey MH - Child OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Counseling OT - Family physician OT - Preventive health OT - Primary care OT - Screening COIS- Declarations. Competing interests: The authors declare no competing interests. Declaration of generative AI and AI-assisted technologies: During the preparation of this work, the author(s) used ChatGPT-4o (OpenAI, 2025) in order to improve grammar, language clarity, and phrasing. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication. EDAT- 2026/10/11 05:38 MHDA- 2026/10/11 05:39 CRDT- 2026/10/10 23:41 PHST- 2026/05/13 00:00 [received] PHST- 2026/10/01 00:00 [accepted] PHST- 2026/09/25 00:00 [revised] PHST- 2026/10/11 05:39 [medline] PHST- 2026/10/11 05:38 [pubmed] PHST- 2026/10/10 23:41 [entrez] AID - 10.1007/s00431-026-07484-3 [pii] AID - 10.1007/s00431-026-07484-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 10;185(11):828. doi: 10.1007/s00431-026-07484-3. PMID- 42859217 OWN - NLM STAT- Publisher LR - 20261010 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) DP - 2026 Oct 10 TI - Physical Activity Counselling for Children with Congenital Heart Disease: A Pilot Study. LID - 10.1007/s00246-026-04469-9 [doi] AB - It is still not known how to best help children with congenital heart disease (CHD) be more active despite many previous interventions. This study aimed to determine the feasibility and acceptability of a theoretically-based physical activity (PA) counselling intervention. This is a mixed-methods pilot study of children ages 9-12 with moderate-to-complex CHD. A 12-week intervention based on behaviour change theory was designed. Participants who did not meet the World Health Organization PA guidelines (measured via accelerometers) and expressed readiness to change (measured via questionnaires) at baseline qualified. The intervention consisted of six virtual sessions with a PA counsellor, during which participants engaged in workbook activities to learn strategies to engage in PA. Intervention feasibility (recruitment, retention, completion of measures, remote implementation, session and intervention length) and acceptability (compliance, interview feedback) were assessed. PA was measured post-intervention and one year later. Thirty-three children were recruited (recruitment success: 51%). Nine out of 12 eligible participants completed the intervention (retention: 75%) with few technical difficulties (14.5%). Completion rates of PA metrics declined over the study. It took the PA counsellor 15.5 h on average per participant to conduct the intervention. Compliance was high (attendance: 100%, workbook activity completion: 64.4%). During feedback interviews, participants denoted the importance of engaging the whole family, promoting participant autonomy and empowerment, and identified lessons learned. Although this intervention was acceptable to children with CHD, the feasibility remains uncertain given recruitment challenges and time commitment required. Successful components should be considered when designing future interventions. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Fukakusa, Bianca M AU - Fukakusa BM AD - Division of Cardiology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada. FAU - Bennett, Erica V AU - Bennett EV AD - School of Kinesiology, Faculty of Education, University of British Columbia, Vancouver, BC, Canada. FAU - Voss, Christine AU - Voss C AD - Centre for Chronic Disease Prevention and Management, Faculty of Medicine, University of British Columbia, Kelowna, BC, Canada. FAU - Harris, Kevin C AU - Harris KC AD - Division of Cardiology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada. kharris2@cw.bc.ca. AD - Children's Heart Centre, BC Children's Hospital, 1F3-4480 Oak Street, Vancouver, BC, V6H 3V4, Canada. kharris2@cw.bc.ca. LA - eng PT - Journal Article DEP - 20261010 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM OTO - NOTNLM OT - Congenital heart disease OT - Feasibility OT - Intervention OT - Physical activity OT - Pilot study COIS- Declarations. Competing Interests: The authors declare no competing interests. Ethical Approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by The University of British Columbia (H20-00848). Consent to Participate: Written informed consent and assent were obtained from parents/guardians and participants, respectively. EDAT- 2026/10/11 05:38 MHDA- 2026/10/11 05:38 CRDT- 2026/10/10 23:34 PHST- 2026/05/29 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/11 05:38 [medline] PHST- 2026/10/11 05:38 [pubmed] PHST- 2026/10/10 23:34 [entrez] AID - 10.1007/s00246-026-04469-9 [pii] AID - 10.1007/s00246-026-04469-9 [doi] PST - aheadofprint SO - Pediatr Cardiol. 2026 Oct 10. doi: 10.1007/s00246-026-04469-9. PMID- 42858697 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 66 DP - 2026 Nov TI - Dietary patterns and adverse pregnancy outcomes: Complementary insights from a priori and a posteriori approaches in a prospective cohort. PG - 106812 LID - S0261-5614(26)00239-6 [pii] LID - 10.1016/j.clnu.2026.106812 [doi] AB - BACKGROUND & AIMS: Maternal diet during pregnancy may influence fetal growth, but evidence based on dietary-pattern approaches remains scarce. We characterized prenatal dietary patterns in a pregnancy cohort using two a priori diet-quality indices and an unsupervised a posteriori data-driven approach, and evaluated their associations with gestational and neonatal outcomes, and assessed the overlap between both methodological approaches. METHODS: We analyzed 595 mother-infant dyads from the Nutrition in Early Life and Asthma (NELA) birth cohort. Maternal diet at 19-22 weeks' gestation was assessed using a validated 123-item food frequency questionnaire. Adherence to the Mediterranean diet and to the Planetary Health diet was quantified using the relative Mediterranean Diet score (rMED) and the Planetary Health Diet Index (PHDI). In addition, we used principal components analysis (PCA) on energy-adjusted food groups, and then hierarchical clustering on the retained scores to identify real-world dietary patterns. Multivariable linear regression analysis was used to explore the association between dietary patterns and gestational weight gain (GWG), neonatal birth weight, and head circumference. A multinomial logistic regression model assessed the capacity of a priori indices to predict cluster membership, evaluated through McFadden's pseudo-R(2), overall accuracy, and Cohen's kappa. RESULTS: Five dietary clusters were identified, with the following proportion of the population in each cluster: Cluster I (9.7%), Cluster II (31.1%), Cluster III (46.7%), Cluster IV (11.4%), and Cluster V (1.0%). Cluster II showed the highest adherence to both indices (mean rMED 9.4; mean PHDI 85.6). Cluster IV (second highest adherence) was consistently associated with lower GWG and higher birth weight compared with Cluster II in adjusted models (-1.28 kg; 95% CI -2.55 to -0.02 and 134.4 g; 95% CI 30.42 to 238.4, respectively) but not head circumference. No associations were found for the rest of clusters or rMED and PHDI indexes. The comparison between approaches revealed poor classification accuracy (55.5%), and slight-to-fair agreement (Cohen's kappa = 0.24). CONCLUSION: An empirically derived dietary profile characterized by vegetables, tubers, legumes, and dairy intake, was associated with lower GWG and higher birth weight. The limited agreement between approaches highlights that a priori indices and data-driven methods capture complementary dimensions of diet, supporting their combined use. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Notario Barandiaran, Leyre AU - Notario Barandiaran L AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, NH, USA. Electronic address: Leyre.Notario.Barandiaran@dartmouth.edu. FAU - Diaz Coto, Susana AU - Diaz Coto S AD - Department of Orthopaedics, Dartmouth Health. Geisel School of Medicine at Dartmouth, NH, USA. FAU - Martinez Camblor, Pablo AU - Martinez Camblor P AD - Department of Anesthesiology, Dartmouth Health. Geisel School of Medicine at Dartmouth, NH, USA; Faculty of Health Sciences, Universidad Autonoma de Chile, Chile. FAU - Martinez-Gracia, Carmen AU - Martinez-Gracia C AD - Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. FAU - Suarez-Martinez, Clara AU - Suarez-Martinez C AD - Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. FAU - Santaella-Pascual, Marina AU - Santaella-Pascual M AD - Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. FAU - Prieto-Sanchez, M Teresa AU - Prieto-Sanchez MT AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; Obstetrics and Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain. FAU - Sanchez-Ferrer, Maria Luisa AU - Sanchez-Ferrer ML AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; Obstetrics and Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain. FAU - Morales, Eva AU - Morales E AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; Division of Preventive Medicine and Public Health, Department of Public Health Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain; CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - Karagas, Margaret R AU - Karagas MR AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, NH, USA. FAU - Signes-Pastor, Antonio J AU - Signes-Pastor AJ AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Unidad de Epidemiologia de la Nutricion. Universidad Miguel Hernandez, Alicante, Spain; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Spain. Electronic address: asignes@umh.es. CN - of the NELA Study Group LA - eng PT - Journal Article DEP - 20261005 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Prospective Studies MH - *Pregnancy Outcome/epidemiology MH - Adult MH - Diet, Mediterranean/statistics & numerical data MH - Infant, Newborn MH - *Maternal Nutritional Physiological Phenomena MH - *Diet/statistics & numerical data/methods/adverse effects MH - Birth Weight MH - Gestational Weight Gain OTO - NOTNLM OT - Birth outcomes OT - Dietary assessment methods OT - Dietary patterns OT - Gestational weight gain OT - Mediterranean diet OT - Planetary health diet COIS- Conflict of interest The authors declare no conflict of interest. EDAT- 2026/10/11 04:08 MHDA- 2026/10/28 23:26 CRDT- 2026/10/10 19:25 PHST- 2026/03/25 00:00 [received] PHST- 2026/09/21 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/28 23:26 [medline] PHST- 2026/10/11 04:08 [pubmed] PHST- 2026/10/10 19:25 [entrez] AID - S0261-5614(26)00239-6 [pii] AID - 10.1016/j.clnu.2026.106812 [doi] PST - ppublish SO - Clin Nutr. 2026 Nov;66:106812. doi: 10.1016/j.clnu.2026.106812. Epub 2026 Oct 5. PMID- 42858496 OWN - NLM STAT- Publisher LR - 20261022 IS - 1878-9307 (Electronic) IS - 1878-9293 (Print) IS - 1878-9293 (Linking) VI - 82 DP - 2026 Oct 6 TI - Longitudinal associations between screen time activities and working memory neural signatures in adolescents: Sex differences and contextual moderation. PG - 101836 LID - S1878-9293(26)00178-7 [pii] LID - 10.1016/j.dcn.2026.101836 [doi] LID - 101836 AB - INTRODUCTION: Adolescent screen media activity (SMA) has increased, yet its longitudinal associations with neurocognitive development and mental health remain unclear across activities and contexts. METHODS: This longitudinal cohort study used data from the Adolescent Brain Cognitive Development (ABCD) Study (release 6.0) with four assessments (baseline, year 2, year 4, and year 6). Participants were recruited across 21 U.S. sites to reflect demographic diversity. Children with valid neuroimaging and behavioral data were included, adjusting for demographic, behavioral, and psychiatric confounders. Working memory (WM) neural signature (NS) scores were derived using elastic net classification of EN-back fMRI activation during 0-back and 2-back conditions. SMA included time spent video gaming, watching television, texting, and social media. Cognitive performance was measured using EN-back accuracy, and mental health symptoms using Child Behavior Checklist internalizing and externalizing scores. Moderation analyses examined family conflict, sleep disturbance, and physical activity. RESULTS: The analytic sample included 9931 participants (47.2% female). Higher NS scores were associated with better 0-back and 2-back accuracy. Greater video gaming, texting, and television watching were associated with lower NS scores. Sex-stratified analyses showed among males, more screen time was associated with lower NS scores, a multivariate measure of how separable neural activation patterns are between the 2-back and 0-back conditions. These associations were specific to the EN-back task and were adjusted for general cognitive ability. Higher degrees of family conflict increased the association between NS with texting, and video gaming and externalizing symptoms among males. Sleep disturbance and physical activity also moderated associations with internalizing and externalizing symptoms, with sex-specific patterns. CONCLUSIONS: WM-related neural function was associated with cognitive performance and SMA engagement, differing by sex and environmental context, highlighting complex associations between neurocognitive development, media use, and mental health. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Arekatla, Sahithi AU - Arekatla S AD - University of Vermont, Department of Psychiatry, Burlington, Vermont, United States. Electronic address: sahithi.arekatla@uvm.edu. FAU - Barrows, Anthony AU - Barrows A AD - University of Vermont, Department of Psychiatry, Burlington, Vermont, United States. FAU - Cioffredi, Leigh-Anne AU - Cioffredi LA AD - University of Vermont, Department of Psychiatry, Burlington, Vermont, United States. FAU - Albaugh, Matthew D AU - Albaugh MD AD - University of Vermont, Department of Psychiatry, Burlington, Vermont, United States. FAU - Allgaier, Nicholas AU - Allgaier N AD - University of Vermont, Department of Psychiatry, Burlington, Vermont, United States. FAU - Allred, Mckay AU - Allred M AD - University of Vermont, Department of Psychiatry, Burlington, Vermont, United States. FAU - Baranger, David AU - Baranger D AD - Medical College of Wisconsin, Department of Pharmacology and Toxicology, Milwaukee, WI, United States. FAU - Potter, Alexandra AU - Potter A AD - University of Vermont, Department of Psychiatry, Burlington, Vermont, United States. FAU - Garavan, Hugh P AU - Garavan HP AD - University of Vermont, Department of Psychiatry, Burlington, Vermont, United States. FAU - Chaarani, Bader AU - Chaarani B AD - University of Vermont, Department of Psychiatry, Burlington, Vermont, United States. Electronic address: bader.chaarani@uvm.edu. LA - eng GR - R01 MH133138/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20261006 PL - Netherlands TA - Dev Cogn Neurosci JT - Developmental cognitive neuroscience JID - 101541838 SB - IM PMC - PMC13678101 OTO - NOTNLM OT - Family conflict OT - Mental Health OT - Neural Signatures OT - Screen Media Activity OT - Task fMRI OT - Working Memory COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/11 04:08 MHDA- 2026/10/11 04:08 PMCR- 2026/10/06 CRDT- 2026/10/10 19:15 PHST- 2026/03/31 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/11 04:08 [medline] PHST- 2026/10/11 04:08 [pubmed] PHST- 2026/10/10 19:15 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - S1878-9293(26)00178-7 [pii] AID - 101836 [pii] AID - 10.1016/j.dcn.2026.101836 [doi] PST - aheadofprint SO - Dev Cogn Neurosci. 2026 Oct 6;82:101836. doi: 10.1016/j.dcn.2026.101836. PMID- 42858478 OWN - NLM STAT- Publisher LR - 20261010 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 153 DP - 2026 Sep 17 TI - Lean soft tissue and appendicular lean soft tissue in adolescent soccer players: new predictive equations using raw multifrequency impedance analysis data. PG - 113435 LID - S0899-9007(26)00342-4 [pii] LID - 10.1016/j.nut.2026.113435 [doi] AB - BACKGROUND: As determinants of soccer player performance, lean soft tissue (LST) and appendicular lean soft tissue (ALST) require accurate, segment-specific assessment. OBJECTIVE: This study aimed to develop LST and ALST predictive equations from multi-frequency bioelectrical impedance analysis data at 50 and 500 kHz using raw data from an octapolar device and evaluate their predictive performance using dual-energy X-ray absorptiometry as a reference method via split-sample validation. METHODS: Multiple linear regression models were developed using body mass, impedance index, and maturity offset as predictors. Model performance was evaluated using adjusted R(2), standard error of estimate (SEE), root mean square error, mean absolute error, Lin's concordance correlation coefficient (CCC), and Bland-Altman agreement analysis. Participants were randomly allocated into a development (n = 100) and an independent validation subset (n = 49). RESULTS: Predictive performance was comparable between frequencies, with high explanatory power (R(2) for LST = 0.953-0.955; ALST = 0.931-0.932) and low prediction error (SEE  .90). Structural equation modeling with bootstrapped mediation analysis was used to examine the direct and indirect associations between the cognitive dimension and children's physical activity. RESULTS: Declarative knowledge showed a small but significant direct association with the number of active days (beta = .10), with a complementary mediation via motor abilities (beta = .12). Procedural knowledge followed an 'indirect-only pattern' on number of sports and exercises performed via the affective dimension (beta = .09). CONCLUSION: Knowledge showed limited direct associations with physical activity but indirect pathways via physical and affective dimensions, highlighting the potential of embedding cognitive content in active learning experiences. Promoting physical literacy in physical activity settings should address all its dimensions and embed knowledge acquisition within physical activity. CI - (c) 2026 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier B.V. FAU - Schuck, Tizian AU - Schuck T AD - Bayreuth Center of Sport Science, Chair of Social and Health Sciences, University of Bayreuth, Universitatsstrasse 30, Bayreuth, 95447, Germany. AD - Department of Sport Science and Sport, Chair of Education in Sport, Friedrich-Alexander-University of Erlangen-Nurnberg, Gebbertstrasse 123b, Erlangen, 91058, Germany. FAU - Carl, Johannes AU - Carl J AD - Department of Sport and Human Movement Sciences , University of Vienna, Auf der Schmelz 6a, Wien, 1150, Austria. FAU - Tittlbach, Susanne AU - Tittlbach S AD - Bayreuth Center of Sport Science, Chair of Social and Health Sciences, University of Bayreuth, Universitatsstrasse 30, Bayreuth, 95447, Germany. LA - eng PT - Journal Article DEP - 20260923 PL - Singapore TA - J Exerc Sci Fit JT - Journal of exercise science and fitness JID - 101198241 PMC - PMC13651661 OTO - NOTNLM OT - Cognitive dimension OT - Daily behavior OT - Health-related knowledge OT - Mediation analysis COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/23 CRDT- 2026/10/10 14:30 PHST- 2026/06/07 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 14:30 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - S1728-869X(26)00085-7 [pii] AID - 200524 [pii] AID - 10.1016/j.jesf.2026.200524 [doi] PST - ppublish SO - J Exerc Sci Fit. 2026 Oct;24(4):200524. doi: 10.1016/j.jesf.2026.200524. Epub 2026 Sep 23. PMID- 42857145 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261010 LR - 20261012 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Effects of high-intensity interval training versus continuous aerobic training on body weight, body mass index, and body fat percentage in youth with overweight or obesity: a systematic review and meta-analysis. PG - 1678900 LID - 10.3389/fped.2026.1678900 [doi] LID - 1678900 AB - BACKGROUND: Overweight and obesity in youth are associated with substantial short- and long-term health burdens, and structured exercise is a central component of management. Whether HIIT offers greater improvements in body composition than continuous aerobic training remains uncertain. METHODS: This systematic review and meta-analysis followed PRISMA 2020. PubMed, Embase, Web of Science, CNKI, Wanfang, and VIP were searched from inception to December 31, 2024 for randomized trials directly comparing high-intensity interval-based training, including high-intensity interval exercise and sprint-interval protocols, with continuous aerobic training in youth with overweight or obesity. Outcomes were body weight, BMI, and body fat percentage. Risk of bias was assessed with RoB 2. Random-effects models with REML estimation and modified Hartung-Knapp inference generated mean differences (MDs) and 95% confidence intervals (CIs). Sensitivity, subgroup, and small-study-effect analyses were also performed. RESULTS: Fourteen independent randomized trials were included. For body weight, 13 trials involving 409 participants showed no statistically significant difference between HIIT and continuous aerobic training (MD = -0.37 kg, 95% CI -0.89 to 0.15; P = 0.146; I (2) = 0%). For BMI, 14 trials involving 432 participants also showed no significant difference (MD = -0.14 kg/m(2), 95% CI -0.31 to 0.02; P = 0.089; I (2) = 0%). For body fat percentage, 11 trials involving 331 participants showed no significant difference (MD = -0.33 percentage points, 95% CI -1.33 to 0.67; P = 0.481), with moderate-to-substantial heterogeneity (I (2) = 60.3%). Sensitivity analyses did not materially alter the findings, and subgroup analyses did not identify reliable effect modification by weekly frequency, intervention duration, or mean age. Egger's tests did not detect statistically significant small-study effects. One trial was at low overall risk of bias, whereas 13 raised some concerns. CONCLUSION: Randomized evidence identified through December 31, 2024 does not show that HIIT provides greater reductions in body weight, BMI, or body fat percentage than continuous aerobic training. HIIT may be considered an alternative exercise format, but the limited evidence base and heterogeneity in body fat outcomes warrant cautious interpretation. CI - (c) 2026 Jin, Zhou and Zhang. FAU - Jin, Yuan AU - Jin Y AD - People's Sports Publishing House, Beijing, China. FAU - Zhou, Yuanli AU - Zhou Y AD - Chongqing Agricultural Mechanization School, Chongqing, China. FAU - Zhang, Huaxing AU - Zhang H AD - City University Malaysia, Petaling Jaya, Selangor, Malaysia. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260925 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13649959 OTO - NOTNLM OT - body composition OT - continuous aerobic training OT - high-intensity interval training OT - meta-analysis OT - obesity OT - overweight OT - systematic review OT - youth COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/25 CRDT- 2026/10/10 14:26 PHST- 2025/08/03 00:00 [received] PHST- 2026/04/28 00:00 [revised] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 14:26 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1678900 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 25;14:1678900. doi: 10.3389/fped.2026.1678900. eCollection 2026. PMID- 42857025 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261010 LR - 20261012 IS - 2296-634X (Print) IS - 2296-634X (Electronic) IS - 2296-634X (Linking) VI - 14 DP - 2026 TI - MAFLD and impaired bone formation in children: association with reduced serum LCAT. PG - 1902360 LID - 10.3389/fcell.2026.1902360 [doi] LID - 1902360 AB - PURPOSE: To evaluate bone metabolism indicators and serum lecithin-cholesterol acyltransferase (LCAT) levels in children with metabolic dysfunction-associated fatty liver disease (MAFLD), and to explore their interrelationship. PATIENTS AND METHODS: This study enrolled 127 children aged 6-14 years, classified into control (n = 42), obesity without hepatic steatosis (n = 41), and MAFLD (n = 44) groups. All participants underwent clinical evaluation, laboratory testing, and liver ultrasonography. Serum LCAT was quantified by enzyme-linked immunosorbent assay (ELISA). Bone turnover markers, including procollagen type I N-terminal propeptide (PINP), beta-C-terminal telopeptide of type I collagen (beta-CTX), and 25-hydroxyvitamin D [25-(OH) D], were measured via electrochemiluminescence. Independent risk factors for impaired bone formation were analyzed using multivariable ordinal logistic regression. RESULTS: Serum LCAT concentrations were highest in controls (58.27 +/- 4.43 mg/L), followed by obesity without hepatic steatosis (46.13 +/- 3.37 mg/L), and lowest in the MAFLD group (40.71 +/- 3.44 mg/L) (P < 0.001). The proportion of children with PINP below the 25th percentile was significantly greater in the MAFLD group (88.64%) than in obesity (48.78%) and control groups (35.71%) (P < 0.001). Significant intergroup differences were observed for 25-(OH) D, PINP values, PINP grade, and PINP/beta-CTX ratio; PINP grade distribution differed among groups (P < 0.001), whereas beta-CTX grade did not. Spearman analysis revealed significant correlations of LCAT with HDL-C, AST, ALT, fatty liver status, 25-(OH) D, and PINP grade (all P < 0.001). Multivariable ordinal logistic regression identified MAFLD (OR = 4.74, 95% CI: 1.41-15.99, P = 0.012) and older age (OR = 1.38, 95% CI: 1.08-1.75, P = 0.009) as independent factors associated with lower PINP grade, whereas LCAT was not independently associated with PINP grade. CONCLUSION: MAFLD was independently associated with lower PINP status in children. Reduced serum LCAT levels were associated with MAFLD and unfavorable bone formation status but were not independently associated with PINP grade after multivariable adjustment. LCAT may therefore represent an associated biomarker within the liver-bone axis, requiring validation through prospective studies, formal mediation analyses, and mechanistic experiments. CI - Copyright (c) 2026 Zhu, Xu, Yang, Sun and Yang. FAU - Zhu, Lingyan AU - Zhu L AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China. AD - Department of Pediatrics, Yingfeng Branch, General Hospital of the Medical Consortium of Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang, China. FAU - Xu, Lin AU - Xu L AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China. FAU - Yang, Lanshu AU - Yang L AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China. AD - Department of Pediatrics, Chongzhou Maternal and Child Healthcare Hospital, Chengdu, Sichuan, China. FAU - Sun, Baolan AU - Sun B AD - Department of Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. FAU - Yang, Weixia AU - Yang W AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260925 PL - Switzerland TA - Front Cell Dev Biol JT - Frontiers in cell and developmental biology JID - 101630250 PMC - PMC13649763 OTO - NOTNLM OT - LCAT OT - MAFLD OT - bone metabolism OT - liver-bone axis OT - obesity OT - pediatrics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/25 CRDT- 2026/10/10 13:26 PHST- 2026/06/07 00:00 [received] PHST- 2026/09/02 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 13:26 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 1902360 [pii] AID - 10.3389/fcell.2026.1902360 [doi] PST - epublish SO - Front Cell Dev Biol. 2026 Sep 25;14:1902360. doi: 10.3389/fcell.2026.1902360. eCollection 2026. PMID- 42856855 OWN - NLM STAT- MEDLINE DCOM- 20261010 LR - 20261012 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Rare endocannabinoid system variants identified by whole-exome sequencing and structural modeling in adults with severe obesity predominantly of childhood onset. PG - 1862926 LID - 10.3389/fendo.2026.1862926 [doi] LID - 1862926 AB - BACKGROUND: The endocannabinoid system (ECS) regulates key processes in energy homeostasis, but its contribution to severe obesity beginning in childhood or adolescence remains incompletely understood. This study aimed to identify rare variants in ECS genes and evaluate their potential structural effects. METHODS: A total of 93 adults with severe obesity beginning before 21 years of age (BMI >/= 35 kg/m(2)) were recruited from two specialized obesity programs; among participants with onset information, 97.8% reported childhood onset. Whole-exome sequencing was performed, followed by targeted analysis of ECS-related genes. Rare variants (allele frequency <1%) were confirmed by Sanger sequencing and assessed using in silico pathogenicity prediction and molecular modeling. In silico saturation mutagenesis of all 19 possible substitutions at each variant position was additionally performed using three complementary stability predictors based on different methodological principles (FoldX, Pythia and DDMut), together with AlphaMissense. RESULTS: Nine rare variants were identified in twelve individuals, seven of which were defined as variants of uncertain significance (VUS). Among the observed variants, FAAH p.(Arg326Pro) showed the most concordant predicted impact: it ranked as the most destabilizing substitution at position 326 by FoldX (DeltaDeltaG = +3.04 kcal/mol; rank 1 of 19) and was the only observed variant classified as likely pathogenic by AlphaMissense (0.884). Arg326 lies 24.3 A from the catalytic triad (Lys142-Ser217-Ser241), consistent with a predicted effect on fold stability rather than direct disruption of the active site. Conversely, at DAGLA position 750, all 19 substitutions were predicted as neutral by FoldX and DDMut and as likely benign by AlphaMissense, consistent with predicted structural tolerance at this position. No anthropometric or metabolic parameter differed significantly between carriers and non-carriers after correction for multiple testing. CONCLUSIONS: Rare ECS variants, including a previously unreported FAAH p.(Arg326Pro) substitution, were identified in adults with severe obesity, predominantly with childhood onset. These in silico analyses are predictive and provide computational evidence for prioritizing candidate variants, notably FAAH p.(Arg326Pro); they do not, by themselves, establish pathogenicity or a causal relationship with the phenotype, which will require functional validation. CI - Copyright (c) 2026 Salum, Souza, Antunes, Assis, Gouvea, Teixeira, Melo, Palhinha, Abreu, Alves, Silva, Zembrzuski, Campos Junior, Maya-Monteiro, Bozza, da Fonseca and Carneiro. FAU - Salum, Kaio Cezar Rodrigues AU - Salum KCR AD - Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. AD - Molecular Genetics Laboratory, Paulo Niemeyer State Institute of the Brain, Rio de Janeiro, Brazil. FAU - de Souza, Ritiele Bastos AU - de Souza RB AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Laboratory for Applied Genomics and Bioinnovations, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Antunes, Deborah AU - Antunes D AD - Laboratory for Applied Genomics and Bioinnovations, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Assis, Izadora Sthephanie da Silva AU - Assis ISDS AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Gouvea, Laura Wendling AU - Gouvea LW AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Teixeira, Myrela Ribeiro AU - Teixeira MR AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Human Genetics Laboratory, Institute of Biology, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil. FAU - de Melo, Marilia Alves Figueira AU - de Melo MAF AD - Cellular Microbiology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Palhinha, Lohanna AU - Palhinha L AD - Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Abreu, Gabriella de Medeiros AU - Abreu GM AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Genetics Laboratory, Grande Rio University/AFYA, Rio de Janeiro, Brazil. FAU - Alves, Nathalia da Silva AU - Alves NDS AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Genetics Laboratory, Grande Rio University/AFYA, Rio de Janeiro, Brazil. FAU - Silva, Tamara AU - Silva T AD - Genetics Laboratory, Grande Rio University/AFYA, Rio de Janeiro, Brazil. FAU - Zembrzuski, Veronica Marques AU - Zembrzuski VM AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Campos Junior, Mario AU - Campos Junior M AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Maya-Monteiro, Clarissa Menezes AU - Maya-Monteiro CM AD - Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Bozza, Patricia Torres AU - Bozza PT AD - Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - da Fonseca, Ana Carolina Proenca AU - da Fonseca ACP AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Genetics Laboratory, Grande Rio University/AFYA, Rio de Janeiro, Brazil. FAU - Carneiro, Joao Regis Ivar AU - Carneiro JRI AD - Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng PT - Journal Article DEP - 20260925 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Endocannabinoids) RN - EC 3.5.1.- (Fatty Acid Amide Hydrolases) RN - EC 3.5.- (Amidohydrolases) SB - IM MH - Humans MH - *Endocannabinoids/genetics/metabolism MH - Female MH - Exome Sequencing MH - *Obesity, Morbid/genetics/metabolism MH - Adult MH - Fatty Acid Amide Hydrolases MH - Male MH - Age of Onset MH - Models, Molecular MH - *Amidohydrolases/genetics/chemistry MH - Young Adult MH - Adolescent MH - Child MH - Mutation MH - Genetic Variation PMC - PMC13649445 OTO - NOTNLM OT - FAAH OT - childhood-onset obesity OT - endocannabinoid system OT - molecular modeling OT - rare genetic variants COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/25 CRDT- 2026/10/10 12:03 PHST- 2026/04/22 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 12:03 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 10.3389/fendo.2026.1862926 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 25;17:1862926. doi: 10.3389/fendo.2026.1862926. eCollection 2026. PMID- 42856768 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261010 LR - 20261012 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Low baseline alanine aminotransferase is associated with primary non-response to infliximab induction in pediatric Crohn's disease: a retrospective cohort study. PG - 1948999 LID - 10.3389/fped.2026.1948999 [doi] LID - 1948999 AB - BACKGROUND: Low alanine aminotransferase (ALT) has been associated with unfavorable inflammatory and nutritional phenotypes, but its relationship with infliximab (IFX) response in pediatric Crohn's disease (CD) is uncertain. METHODS: We retrospectively studied 116 children with CD who received IFX induction at weeks 0, 2, and 6 and underwent response assessment at approximately week 14. Low ALT was defined as <10 U/L using a rounded, data-informed working threshold. Primary non-response (PNR) required concurrent clinical non-response, biochemical activity, and objective endoscopic or cross-sectional imaging evidence and was independently adjudicated by two pediatric gastroenterologists blinded to baseline ALT. Firth logistic regression assessed the association between low ALT and PNR after adjustment for baseline SES-CD, IFX dose, and concomitant immunomodulator use. RESULTS: Fifty-eight children (50.0%) had low ALT and 21 (18.1%) had PNR. PNR occurred more often with low ALT (27.6% vs. 8.6%; P = 0.008). Low ALT remained associated with PNR after adjustment (OR, 4.03; 95% CI, 1.48-12.65; P = 0.006), and each 5-U/L decrease in ALT was associated with higher odds of PNR (OR, 1.50; 95% CI, 1.04-2.59; P = 0.022). Discrimination was limited (AUC, 0.677; bootstrap 95% CI, 0.547-0.802). CONCLUSION: Low baseline ALT was associated with PNR to IFX in pediatric CD. This exploratory association and the 10-U/L working threshold require external validation and should not guide treatment decisions in isolation. CI - (c) 2026 Wang, Guo and Wu. FAU - Wang, Yuhang AU - Wang Y AD - Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Guo, Cheng AU - Guo C AD - Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Wu, Jie AU - Wu J AD - Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. LA - eng PT - Journal Article DEP - 20260925 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13649988 OTO - NOTNLM OT - alanine aminotransferase OT - biologic therapy OT - inflammatory bowel disease OT - infliximab OT - pediatric Crohn's disease OT - primary non-response COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/25 CRDT- 2026/10/10 11:09 PHST- 2026/07/26 00:00 [received] PHST- 2026/09/04 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 11:09 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1948999 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 25;14:1948999. doi: 10.3389/fped.2026.1948999. eCollection 2026. PMID- 42855966 OWN - NLM STAT- MEDLINE DCOM- 20261010 LR - 20261014 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 58 IP - 1 DP - 2026 Dec TI - How much of the incremental protocol does a lactate threshold need? Agreement between three-stage and five-stage testing across seven lactate-derived indices in swimmers. PG - 2737006 LID - 10.1080/07853890.2026.2737006 [doi] LID - 2737006 AB - BACKGROUND: Incremental lactate testing is widely used to characterize the lactate-velocity relationship in swimmers, but the highest-intensity stages increase testing burden and may be difficult to execute consistently. OBJECTIVE: To determine whether a five-stage protocol can be reduced to three stages without materially changing seven lactate-derived velocity indices, and whether model complexity affects reconstruction. METHODS: Ninety highly trained swimmers completed a 5 x 200 m freestyle incremental test at 80-100% of 200 m personal-best performance. Stage-4 and stage-5 lactate values were reconstructed from the first three stages using participant-specific linear extrapolation and a long short-term memory (LSTM) model. Seven lactate-derived indices were recalculated and compared with full-protocol values using limits of agreement, typical error, ICC(A,1) and equivalence testing. RESULTS: Lactate reconstruction was inaccurate for both models, yet v@Exp-Dmax showed close agreement with the full protocol (bias -0.008 m.s(-1); limits of agreement -0.023 to +0.007 m.s(-1); ICC 0.988) and met the pre-specified equivalence criterion. The other six indices did not meet equivalence. LSTM provided no advantage over linear extrapolation, and reconstructed v@Exp-Dmax preserved the performance-association pattern observed with the full protocol. CONCLUSIONS: A three-stage protocol may support lower-burden longitudinal monitoring of v@Exp-Dmax, but protocol simplification is index-specific and does not establish physiological threshold validity. FAU - Shen, Yupeng AU - Shen Y AUID- ORCID: 0000-0002-2960-2510 AD - School of physical education and sports science, South China Normal University, Guangzhou, China. FAU - Zou, Xinnuo AU - Zou X AD - School of physical education and sports science, South China Normal University, Guangzhou, China. FAU - Chen, Xiaotong AU - Chen X AUID- ORCID: 0000-0002-9260-9395 AD - School of physical education and sports science, South China Normal University, Guangzhou, China. AD - Sports Academy, Guangzhou College of Commerce, Guangzhou, China. FAU - Wu, Xiaobin AU - Wu X AD - School of Physical Education, Chengdu Sport University, Chengdu, China. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 RN - 33X04XA5AT (Lactic Acid) SB - IM MH - Humans MH - *Swimming/physiology MH - *Lactic Acid/blood MH - Male MH - *Exercise Test/methods MH - Female MH - Adolescent MH - *Anaerobic Threshold/physiology MH - *Athletic Performance/physiology MH - Reproducibility of Results PMC - PMC13656679 OTO - NOTNLM OT - Exp-Dmax OT - Lactate threshold OT - incremental testing OT - swimming COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/10/10 05:32 MHDA- 2026/10/10 05:33 PMCR- 2026/10/09 CRDT- 2026/10/10 02:52 PHST- 2026/10/10 05:33 [medline] PHST- 2026/10/10 05:32 [pubmed] PHST- 2026/10/10 02:52 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 2737006 [pii] AID - 10.1080/07853890.2026.2737006 [doi] PST - ppublish SO - Ann Med. 2026 Dec;58(1):2737006. doi: 10.1080/07853890.2026.2737006. Epub 2026 Oct 9. PMID- 42855587 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 9 TI - Obstructive sleep apnoea severity and insulin resistance in children with Prader-Willi Syndrome: the SPISE index as a candidate metabolic marker. LID - 826 [pii] LID - 10.1007/s00431-026-07506-0 [doi] AB - We compared two surrogate markers of insulin sensitivity - the single-point insulin sensitivity estimator (SPISE) and HOMA-IR - and evaluated their associations with OSA severity in children with genetically confirmed PWS and a symptomatic non-syndromic referral group (NSR) with available polysomnography (PSG) and fasting biochemical data. In this single-centre retrospective cross-sectional study, OSA severity was indexed by the obstructive apnoea-hypopnoea index (oAHI), central AHI (cAHI) and oxygen desaturation index (ODI), and caregiver-reported symptoms by the PSQ-SRBD scale. Multivariable models were fitted within the PWS group. Of 458 PSG studies screened, 31 children with PWS and 47 NSR met the inclusion criteria. cAHI was higher in PWS (p < 0.001), and PSQ-SRBD scores were slightly lower, despite a similar oAHI distribution. Within the PWS group, oAHI correlated inversely with SPISE (rho = - 0.378, p = 0.036). In multivariable models adjusted for age, sex, BMI-SDS, and growth hormone therapy, higher oAHI was associated with lower SPISE (B = - 0.154, p = 0.015), whereas the association with ln(HOMA-IR) was borderline (B = 0.081, p = 0.0497). ODI correlated with SPISE (rho = - 0.427, p = 0.017) but not with HOMA-IR (rho = 0.319, p = 0.081). Phase-stratified analyses showed oAHI-SPISE correlations in phases 2 and 3 and an oAHI-HOMA-IR correlation in phase 3. CONCLUSION: In children with PWS, OSA severity was associated with markers of impaired insulin sensitivity. The associations of SPISE with oAHI and ODI support its further investigation as a candidate metabolic correlate of OSA severity. These findings are hypothesis-generating and require validation in larger independent cohorts. WHAT IS KNOWN: * OSA is highly prevalent in PWS. OSA severity is associated with insulin resistance in adults and in non-syndromic children with obesity, but this relationship and the insulin-independent SPISE index have not been evaluated in PWS. WHAT IS NEW: * OSA severity was associated with impaired insulin sensitivity markers in children with PWS. * SPISE, derived from lipids and BMI without fasting insulin, was associated with oAHI and ODI in PWS; it merits further investigation as a candidate metabolic correlate of OSA severity. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Guney, Abdurrahman Zarif AU - Guney AZ AUID- ORCID: 0000-0002-6956-8820 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Akpinar, Osman Talha AU - Akpinar OT AUID- ORCID: 0009-0001-6671-7237 AD - Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Gokden, Meltem AU - Gokden M AUID- ORCID: 0000-0002-8284-0788 AD - Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Yilmaz, Furkan AU - Yilmaz F AUID- ORCID: 0000-0001-6459-9647 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Korkmaz, Cigdem AU - Korkmaz C AUID- ORCID: 0000-0002-2096-2253 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Oztosun, Berrak Nevin AU - Oztosun BN AUID- ORCID: 0000-0001-5649-8045 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Collak, Abdulhamit AU - Collak A AUID- ORCID: 0000-0002-0562-0343 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Turan, Hande AU - Turan H AUID- ORCID: 0000-0003-0121-3756 AD - Division of Paediatric Endocrinology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Bayramoglu, Elvan AU - Bayramoglu E AUID- ORCID: 0000-0002-6732-8823 AD - Division of Paediatric Endocrinology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Evliyaoglu, Olcay AU - Evliyaoglu O AUID- ORCID: 0000-0003-4851-8637 AD - Division of Paediatric Endocrinology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Kilinc Sakalli, Ayse Ayzit AU - Kilinc Sakalli AA AUID- ORCID: 0000-0002-2879-8910 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. kilincayse203@gmail.com. LA - eng PT - Journal Article DEP - 20261009 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Insulin Resistance MH - *Prader-Willi Syndrome/complications/metabolism MH - *Sleep Apnea, Obstructive/diagnosis/etiology MH - Female MH - Cross-Sectional Studies MH - Male MH - Retrospective Studies MH - Polysomnography MH - Severity of Illness Index MH - Biomarkers/blood MH - Child MH - Child, Preschool MH - Adolescent OTO - NOTNLM OT - HOMA-IR OT - Insulin resistance OT - Obstructive sleep apnoea OT - Paediatrics OT - Prader-Willi syndrome OT - SPISE COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. This retrospective study was approved by the Istanbul University-Cerrahpasa Clinical Research Ethics Committee (approval date: 24 December 2025; approval no. E-24687260-604.01-1513367). Consent to participate: This was a retrospective study based on de-identified data extracted from existing medical records collected as part of routine clinical care. Formal informed consent was therefore not sought for the retrospective analysis. Consent to publish: Not applicable. The manuscript contains no individual person's identifying data, images, or videos. Competing interests: The authors declare no competing interests. EDAT- 2026/10/10 05:32 MHDA- 2026/10/10 05:33 CRDT- 2026/10/09 23:37 PHST- 2026/06/13 00:00 [received] PHST- 2026/10/05 00:00 [accepted] PHST- 2026/09/26 00:00 [revised] PHST- 2026/10/10 05:33 [medline] PHST- 2026/10/10 05:32 [pubmed] PHST- 2026/10/09 23:37 [entrez] AID - 10.1007/s00431-026-07506-0 [pii] AID - 10.1007/s00431-026-07506-0 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 9;185(11):826. doi: 10.1007/s00431-026-07506-0. PMID- 42855145 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261026 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Oct 9 TI - Feasibility, Acceptability, and Appropriateness of an 8-Week Supervised Aerobic Exercise Intervention for Adults With Epilepsy: Pilot Randomized Controlled Trial. PG - e97392 LID - 10.2196/97392 [doi] LID - e97392 AB - BACKGROUND: Epilepsy affects multiple dimensions of health. Exercise may serve as a nonpharmacological strategy to improve health outcomes among adults with epilepsy; however, translating this potential into effective and scalable interventions remains challenging. Before advancing to efficacy trials, early-stage research is needed to establish whether exercise interventions are feasible, acceptable, and appropriate for this population. OBJECTIVE: This study aimed to evaluate the feasibility, acceptability, and appropriateness of an 8-week supervised aerobic exercise intervention for adults with epilepsy, guided by the Obesity-Related Behavioral Intervention Trials (ORBIT) model. METHODS: Adults with epilepsy aged 18-65 years were recruited between April 2024 and December 2024 and randomized to either a supervised aerobic exercise intervention (n=4) or a control group (n=2). The exercise group completed an 8-week supervised aerobic exercise program consisting of 50-minute sessions performed 3 days per week. The intervention incorporated behavior change techniques, including goal setting, action planning, habit formation, and commitment contracts to support exercise adherence. Process feasibility outcomes included recruitment, retention, adherence, survey completion, protocol compliance, and safety. Self-reported feasibility, acceptability, and appropriateness were assessed using the Feasibility of Intervention Measure, Acceptability of Intervention Measure, and Intervention Appropriateness Measure. RESULTS: Overall, 34 individuals expressed interest in the study, 25 completed the screening survey, 10 were preliminarily eligible, and 6 were enrolled in the study over 8 months. Recruitment was low, with a recruitment rate of 0.75 participants per month and enrollment achievement of 16.7% of the target sample (target n=36). Retention and adherence were 100%. All exercise participants completed 24/24 sessions, with 100% weekly survey completion. Protocol compliance was high. No seizures occurred during exercise sessions. Mean scores for self-reported feasibility, acceptability, and appropriateness were high (>4 out of 5). CONCLUSIONS: The results of this Phase IIb pilot study suggest that a supervised aerobic exercise intervention for adults with epilepsy is feasible, acceptable, and appropriate to implement among participants who enroll. Recruitment remains the primary challenge to progressing this line of research and may represent a broader field-level barrier. Future trials should focus on improving how adults with epilepsy are reached and engaged in exercise research while preserving intervention strategies that support strong engagement among those who enroll. CI - (c)Sydney Churchill, Jeni Lansing, Angelique Brellenthin, Alison Phillips, Elizabeth Stegemoller, Jacob Meyer. Originally published in JMIR Formative Research (https://formative.jmir.org), 09.10.2026. FAU - Churchill, Sydney AU - Churchill S AUID- ORCID: 0000-0002-0271-0749 AD - Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. FAU - Lansing, Jeni AU - Lansing J AUID- ORCID: 0000-0001-7665-8747 AD - Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States. FAU - Brellenthin, Angelique AU - Brellenthin A AUID- ORCID: 0000-0003-2038-389X AD - Department of Kinesiology, Iowa State University, Ames, IA, United States. FAU - Phillips, Alison AU - Phillips A AUID- ORCID: 0000-0003-1126-1559 AD - Department of Psychology, Iowa State University, Ames, IA, United States. FAU - Stegemoller, Elizabeth AU - Stegemoller E AUID- ORCID: 0000-0002-5287-2295 AD - Department of Kinesiology, Iowa State University, Ames, IA, United States. FAU - Meyer, Jacob AU - Meyer J AUID- ORCID: 0000-0003-3180-5728 AD - Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20261009 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - *Epilepsy/therapy/psychology MH - Female MH - Adult MH - Middle Aged MH - Pilot Projects MH - Feasibility Studies MH - Male MH - *Exercise Therapy/methods/standards MH - *Exercise/psychology MH - Adolescent MH - *Patient Acceptance of Health Care/statistics & numerical data/psychology MH - Aged MH - Young Adult PMC - PMC13695000 OTO - NOTNLM OT - acceptability OT - aerobic exercise OT - epilepsy OT - feasibility OT - intervention COIS- Conflicts of Interest: None declared. EDAT- 2026/10/09 23:31 MHDA- 2026/10/09 23:32 PMCR- 2026/10/09 CRDT- 2026/10/09 19:53 PHST- 2026/04/06 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/12 00:00 [revised] PHST- 2026/10/09 23:32 [medline] PHST- 2026/10/09 23:31 [pubmed] PHST- 2026/10/09 19:53 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - v10i1e97392 [pii] AID - 10.2196/97392 [doi] PST - epublish SO - JMIR Form Res. 2026 Oct 9;10:e97392. doi: 10.2196/97392. PMID- 42853568 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261019 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 10 DP - 2026 Oct 1 TI - A Community-Based Behavioral Intervention and Body Mass Index in School-Aged Children: A Cluster Randomized Clinical Trial. PG - e2638188 LID - 10.1001/jamanetworkopen.2026.38188 [doi] LID - e2638188 AB - IMPORTANCE: Childhood obesity remains a major concern in the US, with increases in body mass index (BMI) observed during and after the COVID-19 pandemic. Scalable behavioral interventions are needed to support obesity prevention in community settings. OBJECTIVE: To evaluate the efficacy of a community-based behavioral intervention (H2GO!) on BMI z scores (zBMIs) among school-aged children. DESIGN, SETTING, AND PARTICIPANTS: This cluster randomized clinical trial was conducted from September 2020 to June 2025 across 11 Boys & Girls Club sites in Massachusetts. Sites were pair-matched and randomized to intervention or usual care condition. Participants included children aged 8 to 13 years and their parents or caregivers. INTERVENTION: Twelve group-based sessions delivered in person over 6 weeks by trained Boys & Girls Club staff using behavioral strategies to reduce sugar-sweetened beverage intake and increase water consumption through health sessions, youth-created narratives, and parent-child activities. Comparison sites received usual programming. MAIN OUTCOMES AND MEASURES: Outcomes were assessed at baseline and at 2, 6, and 12 months using intention-to-treat analyses. The primary outcome was 12-month change from baseline in child zBMI, derived from staff-measured height and weight using standardized protocols. Secondary outcomes included child sugar-sweetened beverage and water intake measured using a validated questionnaire. RESULTS: Among 437 child participants (mean [SD] age, 10.1 [1.2] years; 219 girls [50.1%]), 0.2% were American Indian or Alaska Native, 1.8% were Asian, 15.8% were Black or African American, 42.6% were Hispanic or Latino, and 29.5% were White; 297 (68%) were eligible for free or reduced-price lunch. At baseline, 74 children (16.9%) had overweight, and 161 (36.8%) had obesity. From baseline to 12 months, the mean zBMI did not statistically significantly decrease (-0.11 [95% CI, -0.25 to 0.02]) in the intervention group and did not statistically significantly increase (0.08 [95% CI, -0.04 to 0.20]) in the comparison group; however, the estimated between-group difference in the adjusted mean zBMI change from baseline was statistically significant: -0.19 (95% CI, -0.38 to -0.01; P = .04). Between-group differences in sugar-sweetened beverage and water intake were not significant. CONCLUSIONS AND RELEVANCE: In this cluster randomized clinical trial, a community-based behavioral intervention was associated with a statistically significant between-group difference in zBMI change among school-aged children. Findings support the potential of community-based behavioral interventions in obesity prevention. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04265794. FAU - Wang, Monica L AU - Wang ML AD - Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. AD - Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Alatorre, Selenne AU - Alatorre S AD - Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. FAU - Schwarz, Aviva G AU - Schwarz AG AD - Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. AD - Department of Psychiatry, Boston Medical Center, Boston, Massachusetts. FAU - Weinberg, Janice AU - Weinberg J AD - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts. FAU - Sprague Martinez, Linda AU - Sprague Martinez L AD - Department of Medicine, University of Connecticut School of Social Work, Hartford. FAU - Aldworth, Jennifer AU - Aldworth J AD - Massachusetts Alliance of Boys & Girls Clubs, Ludlow. FAU - Kadel, Rabindra AU - Kadel R AD - Center for Health Data Science, Boston University School of Public Health, Boston, Massachusetts. FAU - Rosal, Milagros C AU - Rosal MC AD - Department of Population and Quantitative Health Sciences, University of Massachusetts T.H. Chan School of Medicine, Worcester. FAU - Lemon, Stephenie C AU - Lemon SC AD - Department of Population and Quantitative Health Sciences, University of Massachusetts T.H. Chan School of Medicine, Worcester. LA - eng SI - ClinicalTrials.gov/NCT04265794 PT - Journal Article PT - Randomized Controlled Trial DEP - 20261001 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Behavior Therapy/methods MH - *Body Mass Index MH - Massachusetts/epidemiology MH - *Pediatric Obesity/prevention & control MH - Sugar-Sweetened Beverages PMC - PMC13653277 COIS- Conflict of Interest Disclosures: Dr Weinberg reported receiving personal fees for being a data monitoring biostatistician from Janssen and Sanofi outside the submitted work. Ms Aldworth reported receiving a National Institutes of Health (NIH)-funded subaward from Boston University, paid to her institution, during the conduct of the study. Dr Rosal reported receiving grants from the NIH during the conduct of the study. No other disclosures were reported. EDAT- 2026/10/09 17:34 MHDA- 2026/10/09 17:35 PMCR- 2026/10/09 CRDT- 2026/10/09 11:34 PHST- 2026/10/09 17:35 [medline] PHST- 2026/10/09 17:34 [pubmed] PHST- 2026/10/09 11:34 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 2855120 [pii] AID - zoi261028 [pii] AID - 10.1001/jamanetworkopen.2026.38188 [doi] PST - epublish SO - JAMA Netw Open. 2026 Oct 1;9(10):e2638188. doi: 10.1001/jamanetworkopen.2026.38188. PMID- 42853511 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261009 IS - 1573-2959 (Electronic) IS - 0167-6369 (Linking) VI - 198 IP - 11 DP - 2026 Oct 9 TI - Environmental occurrence, spatial distribution, and probabilistic dietary risk assessment of cypermethrin and glyphosate residues in agricultural ecosystems of southwestern Nigeria. LID - 1171 [pii] LID - 10.1007/s10661-026-15973-z [doi] AB - Pesticide use in vegetable production raises concerns regarding environmental contamination, food safety, and human health, particularly where pesticide stewardship is inadequate. This study investigated the occurrence, spatial distribution, environmental partitioning, and dietary health risks of cypermethrin and glyphosate in water, sediment, soil, and Amaranthus cruentus collected from 30 sampling sites across three major vegetable-producing settlements in Oyo State, southwestern Nigeria. A total of 240 matrix-season samples were analysed using validated chromatographic methods, generating 480 independent pesticide-specific sample-level observations after analytical duplicates were averaged. Residue data were evaluated using hierarchical mixed-effects modelling, principal component analysis, Moran's I spatial autocorrelation analysis, deterministic dietary risk assessment, empirical Monte Carlo simulation with 10,000 iterations, and a structured survey of vegetable farmers. Glyphosate predominated in soil and sediment, whereas cypermethrin occurred at comparatively higher concentrations in A. cruentus. Significant spatial autocorrelation was detected specifically for glyphosate in sediment (Moran's I = 0.783, p = 0.0003). Deterministic assessment indicated acceptable dietary risk for adults for both pesticides and for glyphosate in children, whereas cypermethrin exceeded the hazard threshold in children (HQ = 1.818). Monte Carlo simulation showed HQ > 1 in 15.09% of adult and 70.47% of child cypermethrin exposure scenarios, while no simulated glyphosate exposure exceeded this threshold. Despite substantial exceedance of selected EU spinach maximum-residue-limit benchmarks, farmer practices indicated limited pesticide stewardship and short pre-harvest intervals. These findings support strengthened pesticide stewardship, residue surveillance, farmer education, and regulatory oversight to improve food safety. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Ojezele, Omolara Jemimah AU - Ojezele OJ AUID- ORCID: 0000-0002-9372-6163 AD - Department of Chemistry/Biochemistry, Federal College of Animal Health and Production Technology, Moor Plantation, Ibadan, Oyo State, Nigeria. omolaraojezele@gmail.com. FAU - Ojezele, Matthew Obaineh AU - Ojezele MO AD - Department of Pharmacology, Delta State University, Abraka, Delta State, Nigeria. LA - eng PT - Journal Article DEP - 20261009 PL - Netherlands TA - Environ Monit Assess JT - Environmental monitoring and assessment JID - 8508350 RN - 1TR49121NP (cypermethrin) RN - 0 (Pyrethrins) RN - TE7660XO1C (Glycine) RN - 4632WW1X5A (Glyphosate) RN - 0 (Pesticide Residues) SB - IM MH - *Pyrethrins/analysis MH - *Glycine/analogs & derivatives/analysis MH - Glyphosate MH - Nigeria MH - Risk Assessment MH - Agriculture MH - *Pesticide Residues/analysis MH - *Environmental Monitoring MH - Ecosystem MH - *Dietary Exposure/statistics & numerical data/analysis MH - Humans MH - Food Contamination/analysis MH - Amaranthus/chemistry MH - Monte Carlo Method OTO - NOTNLM OT - Amaranthus cruentus OT - Environmental partitioning OT - Hierarchical mixed-effects modelling OT - Monte Carlo simulation OT - Moran's I OT - Pesticide stewardship OT - Principal component analysis COIS- Declarations. Ethics approval: Ethical approval for this study was obtained from the Ethics and Research Committee, Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria (Protocol No. RBC/FBMS/DELSU/15/112). The study protocol, including administration of questionnaires to farmers, was reviewed and approved prior to commencement of the research. Consent to participate: Informed consent was obtained from all participants prior to questionnaire administration. Participation was voluntary, and respondents were informed of the purpose of the study and assured of the confidentiality of the information provided. Clinical trial number: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/09 17:34 MHDA- 2026/10/09 17:35 CRDT- 2026/10/09 11:20 PHST- 2026/08/07 00:00 [received] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/09 17:35 [medline] PHST- 2026/10/09 17:34 [pubmed] PHST- 2026/10/09 11:20 [entrez] AID - 10.1007/s10661-026-15973-z [pii] AID - 10.1007/s10661-026-15973-z [doi] PST - epublish SO - Environ Monit Assess. 2026 Oct 9;198(11):1171. doi: 10.1007/s10661-026-15973-z. PMID- 42853195 OWN - NLM STAT- Publisher LR - 20261009 IS - 1532-5040 (Electronic) IS - 0959-3985 (Linking) DP - 2026 Oct 9 TI - From information to action; co-designing pain neuroscience education for adolescents with low back pain: Focus group insights. PG - 1-20 LID - 10.1080/09593985.2026.2743833 [doi] AB - INTRODUCTION: Low back pain (LBP) is a common health problem among adolescents. Adolescents with pain report higher stress, more school absenteeism, poorer academic performance, and frequent healthcare use. LBP during adolescence may increase the risk of pain in adulthood, underscoring the importance of supporting young people in developing strategies to understand and manage pain. OBJECTIVE: To develop educational material based on pain neuroscience education (PNE) through co-design with adolescents experiencing LBP. METHODS: Adolescents 15-19 years old were recruited to review an initial prototype developed by the authors. Four focus group discussions involving 15 participants were conducted and analyzed using Krueger's analysis framework. The findings guided the development of a refined prototype, which was then further improved through an additional focus group with six participants to validate interpretations and adjust content. RESULTS: Four themes captured adolescents' needs in relation to pain education. Need for recognition: "This is about me" emphasized relatable, back-specific information. Need for practical tools and support: "What can I do myself?" reflected adolescents' desire for actionable strategies. A format that sparks interest: "Otherwise I will stop reading" highlighted the importance of engaging, concise content adapted to young people. The pathway from information to useful support: "It must be easy to find" underlined the value of structure and simple navigation. Participants confirmed the relevance of the prototype and suggested adjustments, which guided further refinement. Based on these insights, the final Back To Move prototype was developed as a complement to healthcare services. CONCLUSION: Adolescents with LBP value PNE that is back-specific, practical, trustworthy, and presented in a format adapted to their preferences. When evidence-based knowledge is combined with language and design tailored to the target group, educational material becomes more engaging and supportive. These findings highlight the importance of involving young people as active co-designers of health information. FAU - Ahlqwist, Anna AU - Ahlqwist A AD - Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Danielsson, Louise AU - Danielsson L AD - Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Lundberg, Mari AU - Lundberg M AD - Back in Motion Research Group, Department of Health Promoting Science, Sophiahemmet University, Stockholm, Sweden. AD - Sahlgrenska Academy, University of Gothenburg Centre for Person-Centred Care (GPCC), Gothenburg, Sweden. AD - Pain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium. FAU - Varkey, Emma AU - Varkey E AD - Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Occupational Therapy and Physical Therapy, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Physiother Theory Pract JT - Physiotherapy theory and practice JID - 9015520 SB - IM OTO - NOTNLM OT - Low back pain OT - adolescents OT - physical activity OT - physical therapy EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 10:34 PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 10:34 [entrez] AID - 10.1080/09593985.2026.2743833 [doi] PST - aheadofprint SO - Physiother Theory Pract. 2026 Oct 9:1-20. doi: 10.1080/09593985.2026.2743833. PMID- 42852973 OWN - NLM STAT- Publisher LR - 20261009 IS - 1545-1569 (Electronic) IS - 1055-6656 (Linking) DP - 2026 Oct 9 TI - Predicting Underweight Status in Infants With Cleft Lip and/or Palate in 10 US Children's Hospitals. PG - 10556656261494318 LID - 10.1177/10556656261494318 [doi] AB - ObjectiveTo develop and compare models predicting which infants with cleft lip and/or palate (CL/P) will be underweight at 4 months, using multicenter electronic health record data.DesignUsing data from birth to 3 months, we evaluated 63 anthropometric, clinical, healthcare-utilization, and demographic variables across 6 regression and machine-learning models to identify the strongest predictors of underweight status, overall and by cleft type.SettingTen US children's hospitals in PEDSnet, a national pediatric learning health network, 2009 to 2024.PatientsInfants with CL/P aged 0 to 4.5 months.Main Outcome MeasureUnderweight status at 4 months (range 3.5-4.5), defined as weight-for-age z-score (WAZ) < -2.ResultsAmong 5717 infants with CL/P (19% cleft lip, 35% cleft lip and palate, 46% cleft palate), 25.9% were underweight at 4 months. The strongest predictors were early (0-3 months) growth measures: mean WAZ (58% of predictive value), WAZ velocity, mean length-for-age z-score (LAZ), and LAZ velocity, plus the Child Opportunity Index (a neighborhood socioeconomic measure; approximately 2%). These 5 predictors accounted for >85% of predictive value in every cleft type. All 6 models discriminated similarly (area under the receiver operating characteristic curve 0.87-0.90); GPBoost, which also accounts for hospital differences, produced risk estimates closest to the actual proportion of underweight infants.ConclusionsRoutine early-life growth measures (WAZ, LAZ, and their trajectories), together with neighborhood socioeconomic status, can identify infants with cleft at elevated risk of being underweight before 4 months, helping craniofacial and primary care teams provide timelier feeding and nutrition support and referrals to the highest-risk infants. FAU - Ormanidou, Ioanna AU - Ormanidou I AUID- ORCID: 0009-0001-3520-7269 AD - Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA. RINGGOLD: 145793 FAU - Howard, Waylon AU - Howard W AD - Research Integration Hub, Seattle Children's Research Institute, Seattle, WA, USA. FAU - Bijlani, Kiley AU - Bijlani K AD - Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA. FAU - Denno, Donna M AU - Denno DM AD - General Pediatrics, Seattle Children's Hospital, Seattle, WA, USA. RINGGOLD: 7284 AD - Department of Pediatrics, University of Washington, Seattle, WA, USA. FAU - Amoako-Yirenkyi, Peter AU - Amoako-Yirenkyi P AD - Department of Mathematics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. RINGGOLD: 98763 FAU - Heike, Carrie AU - Heike C AUID- ORCID: 0000-0003-2178-7730 AD - Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA. AD - Department of Pediatrics, University of Washington, Seattle, WA, USA. AD - Craniofacial Center, Seattle Children's Hospital, Seattle, WA, USA. FAU - Adusei, Abraham Owusu AU - Adusei AO AD - Biomedical Data Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Oliphant, Heather AU - Oliphant H AD - Data Coordinating Center, Seattle Children's Research Institute, Seattle, WA, USA. FAU - Crerand, Canice E AU - Crerand CE AUID- ORCID: 0000-0003-0040-6396 AD - Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, OH, USA. RINGGOLD: 2650 FAU - Jackson, Oksana AU - Jackson O AD - Division of Plastic, Reconstructive and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Discolo, Christopher AU - Discolo C AD - Department of Otolaryngology, Children's Hospital Colorado, Charleston, SC, USA. RINGGOLD: 2932 FAU - Vetter, Sarah AU - Vetter S AD - Rehabilitative Services, Ann & Robert H Lurie Children's, Chicago, IL, USA. RINGGOLD: 20212 FAU - Wilson, Kristina AU - Wilson K AD - Texas Children's Hospital, Houston, TX, USA. RINGGOLD: 3984 FAU - Geronimo, Yeraldi AU - Geronimo Y AUID- ORCID: 0009-0009-3702-3429 AD - Division of Plastic & Craniofacial Surgery, Nemours Children's Hospital, Orlando, FL, USA. RINGGOLD: 25104 FAU - Galera, Rhona AU - Galera R AD - Speech Language Pathology in Rehabilitation Services, Stanford Children's Hospital, Palo Alto, CA, USA. RINGGOLD: 24349 FAU - Lyman, Natalie AU - Lyman N AD - Hearing and Speech, Children's National Hospital, Washington, DC, USA. RINGGOLD: 8404 FAU - Whyte, Vanessa AU - Whyte V AD - Hearing and Speech, Children's National Hospital, Washington, DC, USA. RINGGOLD: 8404 FAU - Pajor, Nate AU - Pajor N AD - Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. RINGGOLD: 2518 FAU - McKinney, Christy M AU - McKinney CM AUID- ORCID: 0000-0002-7767-7816 AD - Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA. RINGGOLD: 145793 AD - Department of Pediatrics, University of Washington, Seattle, WA, USA. AD - Craniofacial Center, Seattle Children's Hospital, Seattle, WA, USA. LA - eng PT - Journal Article DEP - 20261009 PL - United States TA - Cleft Palate Craniofac J JT - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JID - 9102566 SB - IM OTO - NOTNLM OT - anthropometry OT - cleft lip OT - cleft lip and palate OT - cleft palate OT - development EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 09:23 PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 09:23 [entrez] AID - 10.1177/10556656261494318 [doi] PST - aheadofprint SO - Cleft Palate Craniofac J. 2026 Oct 9:10556656261494318. doi: 10.1177/10556656261494318. PMID- 42852761 OWN - NLM STAT- Publisher LR - 20261009 IS - 1875-6336 (Electronic) IS - 1573-3963 (Linking) DP - 2026 Sep 30 TI - Pediatric MASLD Evolution: A Distinct Entity from Adult Disease in Pathophysiology, Diagnosis, and Non-invasive Evaluation. LID - 10.2174/0115733963493273260928074302 [doi] AB - With growth in obesity and metabolic dysfunction globally, Metabolic Dysfunction- Associated Steatotic Liver Disease (MASLD) has emerged as the most common chronic liver disease with a rising trend in children and adolescents. Because of differences in frequency, risk factors, histology, disease progression, and therapy response, pediatric MASLD has emerged as a distinct clinical and histological disease, rather than a lesser variant of the adult disease. In addition to contributions from gut microbiota dysbiosis, epigenetic programming, and microRNA regulation, its pathogenesis also involves interactions among hepatic lipid accumulation, insulin resistance, dysregulated lipogenesis, mitochondrial dysfunction, oxidative stress, and inflammatory and fibrogenic pathways. Early onset of MASLD can progress to advanced fibrosis, cirrhosis, and increased long-term cardiovascular risk. Although liver biopsy remains the gold standard for diagnosis, its invasive nature restricts use in pediatric populations, underscoring the need for reliable non-invasive alternatives. This review compares pediatric and adult MASLD and highlights novel non-invasive and emerging biomarkers and imaging techniques for early diagnosis, staging, and risk assessment in the pediatric population. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Pawar, Pratishtha AU - Pawar P AUID- ORCID: 0009-0007-2693-3801 AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. FAU - Bhardwaj, Kanika AU - Bhardwaj K AUID- ORCID: 0000-0003-3097-6023 AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. FAU - Trehan, Deepika AU - Trehan D AUID- ORCID: 0000-0003-0784-5383 AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. FAU - Akhtar, Shagufta AU - Akhtar S AUID- ORCID: 0000-0003-3177-9793 AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. FAU - Gurung, Kamakshyaa AU - Gurung K AUID- ORCID: 0009-0001-7468-3938 AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. FAU - Singh, Nandini AU - Singh N AUID- ORCID: 0009-0001-3761-8897 AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. FAU - Ahmed, Jenifar AU - Ahmed J AUID- ORCID: 0009-0000-5041-2685 AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. FAU - Zaman, Shamsuz AU - Zaman S AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. FAU - Misra, Aroonima AU - Misra A AUID- ORCID: 0000-0003-2884-3600 AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. FAU - Meena, Shyam S AU - Meena SS AUID- ORCID: 0000-0001-5147-1820 AD - Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India. FAU - Siraj, Fouzia AU - Siraj F AUID- ORCID: 0000-0001-7643-7936 AD - ICMR Centre for Cancer Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, India. LA - eng PT - Journal Article DEP - 20260930 PL - United Arab Emirates TA - Curr Pediatr Rev JT - Current pediatric reviews JID - 101240290 SB - IM OTO - NOTNLM OT - MASLD OT - imaging techniques OT - insulin resistance OT - molecular mechanisms OT - non-invasive biomarkers OT - obesity EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 08:04 PHST- 2026/03/27 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 08:04 [entrez] AID - CPR-EPUB-158908 [pii] AID - 10.2174/0115733963493273260928074302 [doi] PST - aheadofprint SO - Curr Pediatr Rev. 2026 Sep 30. doi: 10.2174/0115733963493273260928074302. PMID- 42852721 OWN - NLM STAT- Publisher LR - 20261009 IS - 1473-0804 (Electronic) IS - 1369-7137 (Linking) DP - 2026 Oct 9 TI - Non-linear association between body roundness index and menopausal symptoms in perimenopausal and postmenopausal women. PG - 1-9 LID - 10.1080/13697137.2026.2728616 [doi] AB - OBJECTIVE: This study aimed to examine the association between body roundness index (BRI) and menopausal symptoms in Chinese perimenopausal and postmenopausal women. METHOD: The cross-sectional study enrolled 1795 perimenopausal and postmenopausal women aged 40-69 years who attended the Menopause Clinic at Guangdong Women and Children Hospital. Menopausal symptom severity was assessed using the validated Chinese-modified Kupperman Menopause Index (KMI). Multivariable logistic regression and restricted cubic splines were used to estimate odds ratios (ORs) and identify potential thresholds. RESULTS: Overall, 78.8% of participants reported menopausal symptoms, most of which were mild to moderate. Higher BRI was independently associated with higher odds of menopausal symptoms after adjustment for covariates in a multivariable logistic regression model (OR: 1.20, 95% confidence interval [CI]: 1.05-1.38, p = 0.009). Restricted cubic spline analysis revealed a non-linear relationship between BRI and menopausal symptoms (p-value for non-linearity = 0.014), with a data-derived inflection point at 2.571. Among women with BRI exceeding 2.571, the odds of menopausal symptoms increased progressively with rising BRI (OR: 1.34, 95% CI: 1.11-1.62, p = 0.002). Subgroup analyses showed consistent associations across strata (all p-values for interaction > 0.05). CONCLUSION: The BRI may serve as a useful anthropometric marker for identifying midlife women with greater symptom burden, although causal inference requires prospective validation. FAU - Lyu, Xiao AU - Lyu X AUID- ORCID: 0000-0002-4484-629X AD - Department of Women's Health Care, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Chen, Guozhen AU - Chen G AD - Department of Women's Health Care, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Xia, Jianhong AU - Xia J AUID- ORCID: 0000-0001-8150-2667 AD - Department of Women's Health Care, Guangdong Women and Children Hospital, Guangzhou, China. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Climacteric JT - Climacteric : the journal of the International Menopause Society JID - 9810959 SB - IM OAB - This study explored whether the body roundness index (BRI), a simple measure of body shape based on waist size and height, is associated with menopausal symptoms. Among women attending a menopause clinic in China, higher BRI was linked to an increased likelihood of reporting menopausal symptoms, especially above a certain BRI threshold. Because the study was cross-sectional, it cannot establish that higher BRI causes symptoms, but the results suggest that central body fat may be important when evaluating women during the menopausal transition. OABL- eng OTO - NOTNLM OT - Body roundness index OT - body fat distribution OT - cross-sectional study OT - menopausal symptoms OT - obesity OT - visceral adiposity EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 07:55 PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 07:55 [entrez] AID - 10.1080/13697137.2026.2728616 [doi] PST - aheadofprint SO - Climacteric. 2026 Oct 9:1-9. doi: 10.1080/13697137.2026.2728616. PMID- 42852644 OWN - NLM STAT- Publisher LR - 20261009 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) DP - 2026 Oct 9 TI - Effectiveness of aerobic exercise on motor function and functional capacity in children and adolescents with neuromuscular diseases: a systematic review and meta-analysis. PG - 1-13 LID - 10.1080/09638288.2026.2741341 [doi] AB - PURPOSE: To evaluate the effectiveness of aerobic exercise, alone or combined with other modalities, on motor function and functional capacity in children and adolescents with neuromuscular diseases (NMDs). MATERIALS AND METHODS: A systematic review and meta-analysis were conducted (CRD420251110784). Five databases were searched up to September 2025. Randomized and non-randomized trials assessing aerobic exercise in children/adolescents with NMDs were included. Risk of bias and certainty of evidence were assessed using RoB2, ROBINS-I, and GRADE. Random-effects meta-analyses estimated standardized mean differences (SMD) and 95% confidence intervals (CI). RESULTS: Eleven studies (227 participants) were included. Aerobic exercise showed no significant effect on motor function (SMD = 0.15, 95% CI: -0.10 to 0.40, I(2)=0%) but produced moderate improvements in functional capacity (SMD = 0.51, 95% CI: 0.03 to 0.99, I(2)=78%). Subgroup analyses suggested non-significant effects for sessions <40 min (SMD = 0.83) and combined aerobic plus strength training (SMD = 0.74). Sensitivity analyses showed one study disproportionately influenced results; excluding high-risk studies yielded SMD = 0.36 (I(2)=0%). GRADE indicated low certainty for motor function and very low certainty for functional capacity. CONCLUSIONS: Aerobic exercise is safe and may improve functional capacity but not motor function in pediatric NMDs. Evidence is limited and needs for cautious interpretation and high-quality trials to inform clinical practice. FAU - Gomez-Del Horno, Lydia AU - Gomez-Del Horno L AD - Fundacion NIPACE, Guadalajara, Spain. FAU - Coello-Villalon, Maria AU - Coello-Villalon M AD - Research Group of Pediatric and Neurologic Physiotherapy, ImproveLab, Universidad de Castilla-La Mancha, Toledo, Spain. AD - Faculty of Physiotherapy and Nursing, Department of Nursing, Physiotherapy and Occupational Therapy, University of Castilla-La Mancha, Toledo, Spain. FAU - Dominguez-Lopez, Patricia AU - Dominguez-Lopez P AD - Faculty of Physiotherapy and Nursing, Department of Nursing, Physiotherapy and Occupational Therapy, University of Castilla-La Mancha, Toledo, Spain. AD - Asociacion de Ayuda a la Paralisis Cerebral "Virgen del Valle" (APACE), Toledo, Spain. FAU - Lirio-Romero, Cristina AU - Lirio-Romero C AD - Research Group of Pediatric and Neurologic Physiotherapy, ImproveLab, Universidad de Castilla-La Mancha, Toledo, Spain. AD - Faculty of Physiotherapy and Nursing, Department of Nursing, Physiotherapy and Occupational Therapy, University of Castilla-La Mancha, Toledo, Spain. FAU - Palomo-Carrion, Rocio AU - Palomo-Carrion R AUID- ORCID: 0000-0003-4034-2585 AD - Research Group of Pediatric and Neurologic Physiotherapy, ImproveLab, Universidad de Castilla-La Mancha, Toledo, Spain. AD - Faculty of Physiotherapy and Nursing, Department of Nursing, Physiotherapy and Occupational Therapy, University of Castilla-La Mancha, Toledo, Spain. FAU - Lopez-Munoz, Purificacion AU - Lopez-Munoz P AD - Research Group of Pediatric and Neurologic Physiotherapy, ImproveLab, Universidad de Castilla-La Mancha, Toledo, Spain. AD - Faculty of Physiotherapy and Nursing, Department of Nursing, Physiotherapy and Occupational Therapy, University of Castilla-La Mancha, Toledo, Spain. LA - eng PT - Journal Article PT - Review DEP - 20261009 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM OAB - Aerobic exercise appears safe and feasible for children and adolescents with neuromuscular diseases, supporting its integration into routine rehabilitation without increasing muscle damage or accelerating disease progression.Aerobic training can improve functional capacity and endurance, but does not meaningfully enhance motor function, highlighting the need to combine it with targeted strength or motor control interventions.Rehabilitation professionals should individualize aerobic exercise dosage and consider combining aerobic and resistance training, while future trials clarify optimal intensity, session duration, and program length in pediatric neuromuscular rehabilitation. OABL- eng OTO - NOTNLM OT - Neuromuscular disease OT - aerobic exercise OT - children OT - meta-analysis OT - motor function EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 07:11 PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 07:11 [entrez] AID - 10.1080/09638288.2026.2741341 [doi] PST - aheadofprint SO - Disabil Rehabil. 2026 Oct 9:1-13. doi: 10.1080/09638288.2026.2741341. PMID- 42852487 OWN - NLM STAT- Publisher LR - 20261009 IS - 1876-3405 (Electronic) IS - 1876-3405 (Linking) DP - 2026 Oct 9 TI - Factors associated with measles infection during the 2025-6 outbreak in Burao, Somaliland: a case-control study. LID - ihag102 [pii] LID - 10.1093/inthealth/ihag102 [doi] AB - OBJECTIVES: Somaliland has recurrent measles transmission, but outbreak-specific evidence on modifiable child, household, and health-service factors is limited. We examined factors associated with measles case status during the 2025-6 Burao outbreak. METHODS: We conducted a community-based unmatched case-control study among children aged <15 years from 14 June to 8 July 2026. Cases were enrolled consecutively and controls sampled systematically from households using a random start and every fourth household. Cluster-robust logistic regression estimated adjusted ORs (aORs), with indeterminate responses modeled separately. RESULTS: Among 804 children (290 cases, 514 controls), case status was associated with non-vaccination (aOR 2.12, 95% CI 1.02-4.42), close contact (3.00, 1.72-5.25), reported health-facility attendance (2.79, 1.91-4.06), vaccine unavailability (2.62, 1.17-5.85), and trucked/vendor water (2.98, 2.03-4.36). Prior malnutrition, large-gathering attendance, household vaccination-refusal history, and poor ventilation were also associated. Health-facility attendance referred to the 21 days before rash onset/reference date, but exact visit dates were not collected. CONCLUSION: Measles case status was associated with immunity gaps, contact, household conditions, and service-related factors. Response priorities include reliable vaccine availability, catch-up vaccination, and contact-based action. The health-facility attendance association is temporally ambiguous and does not establish healthcare-associated transmission. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. FAU - Yosef, Dek Kahin AU - Yosef DK AUID- ORCID: 0009-0004-2361-0204 AD - School of Nursing and Midwifery, College of Health Sciences, Burao Central University, Burao, Somaliland, Somalia. AD - School of Postgraduate Studies and Research, University of Burao, Burao, Somaliland, Somalia. FAU - Farah, Mohamed Omer AU - Farah MO AD - School of Nursing and Midwifery, College of Health Sciences, Burao Central University, Burao, Somaliland, Somalia. FAU - Ahmed, Fadumo Osman AU - Ahmed FO AD - School of Nursing and Midwifery, College of Health Sciences, Burao Central University, Burao, Somaliland, Somalia. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Int Health JT - International health JID - 101517095 SB - IM OTO - NOTNLM OT - Somalia OT - case-control studies OT - disease outbreaks OT - measles OT - vaccination OT - vaccination coverage EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 06:51 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 06:51 [entrez] AID - 8894936 [pii] AID - 10.1093/inthealth/ihag102 [doi] PST - aheadofprint SO - Int Health. 2026 Oct 9:ihag102. doi: 10.1093/inthealth/ihag102. PMID- 42851893 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261010 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Lifestyle factors or protective behaviors: which are more strongly associated with upper respiratory tract infections after COVID-19? A cross-sectional study of 1,535 Chinese college students. PG - 1958833 LID - 10.3389/fpubh.2026.1958833 [doi] LID - 1958833 AB - BACKGROUND: Respiratory pathogens have resurged following the COVID-19 pandemic. College students are socially active and often live or study in congregate settings, which may place them at continued risk of upper respiratory tract infection (URTI). OBJECTIVE: To compare the strength of the associations of lifestyle factors and protective behaviors with the number of URTI episodes among college students in the post-COVID-19 period. METHODS: We conducted a cross-sectional survey from June 1 to June 30, 2024, among 2,100 students at six universities in southeastern China. Students were eligible if their first SARS-CoV-2 infection had occurred at least 1 year before the survey. We collected the number of URTI episodes from June 1, 2023, to June 1, 2024, together with demographic, lifestyle, and protective-behavior data. The analysis included 1,535 valid questionnaires. Hierarchical negative binomial regression was used. Demographic variables were entered in the baseline model, after which lifestyle factors and protective behaviors were added sequentially. Their entry order was then reversed to compare the relative contribution of each variable group. RESULTS: When entered first into the baseline model, lifestyle factors produced a greater improvement in model fit than did protective behaviors (Deltachi (2)/df, 7.34 vs. 2.48; AIC, 4981.4 vs. 5067.9). Female sex, higher BMI categories, chronic diseases, COVID-19 vaccination >/=2 doses, daytime sleepiness (IRR, 1.768-2.324), sedentary, vigorous-intensity physical activity were associated with more URTI episodes, whereas sleep duration of at least 7 h and moderate-intensity physical activity were associated with fewer episodes (all p < 0.05). Among protective behaviors, only natural ventilation showed a consistent inverse association (IRR: 0.425-0.475; p < 0.05). Most other behaviors, including handwashing before meals, maintaining 1 m distance, avoiding touching the eyes/mouth/nose and public surfaces, and disinfecting phones and keys were not significantly associated with URTI episodes. CONCLUSION: Lifestyle factors were more strongly associated with URTI episodes than protective behaviors among college students in the post-COVID-19 period. These findings suggest that modifiable lifestyle factors, including sleep, physical activity, and sedentary behavior, as well as natural ventilation, may be relevant targets for campus health strategies. CI - Copyright (c) 2026 He, Li, Li, Ning and Xia. FAU - He, Chenyun AU - He C AD - Health Center, Changzhou University, Changzhou, China. FAU - Li, Ting AU - Li T AD - Changzhou No. 7 People's Hospital, Changzhou, China. FAU - Li, Yanhua AU - Li Y AD - Health Center, Changzhou University, Changzhou, China. FAU - Ning, Jie AU - Ning J AD - Health Center, Changzhou University, Changzhou, China. FAU - Xia, Chunyan AU - Xia C AD - Health Center, Changzhou University, Changzhou, China. LA - eng PT - Journal Article DEP - 20260923 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - China/epidemiology MH - Male MH - *Students/statistics & numerical data/psychology MH - *Respiratory Tract Infections/epidemiology/prevention & control MH - *Life Style MH - *COVID-19/epidemiology MH - Young Adult MH - Universities MH - Adult MH - SARS-CoV-2 MH - Surveys and Questionnaires MH - *Health Behavior MH - Adolescent PMC - PMC13647571 OTO - NOTNLM OT - SARS-CoV-2 OT - cross-sectional study OT - life style OT - risk reduction behavior OT - students OT - upper respiratory tract infection (URTI) COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:41 PMCR- 2026/09/23 CRDT- 2026/10/09 06:00 PHST- 2026/08/05 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/09 11:41 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 06:00 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1958833 [doi] PST - epublish SO - Front Public Health. 2026 Sep 23;14:1958833. doi: 10.3389/fpubh.2026.1958833. eCollection 2026. PMID- 42851230 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261011 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 164 IP - 4 DP - 2026 Aug TI - Prevalence, risk-factors and early prediction of impaired kidney function among indigenous adults in Odisha, India: A secondary analysis. PG - 621-629 LID - 10.25259/IJMR_491_2026 [pii] AB - Background and objectives Native and indigenous communities have a high burden of chronic kidney disease (CKD). The burden of this condition amongst the indigenous populations of India is poorly documented. We estimated the prevalence and determinants of impaired kidney function among indigenous adults in Odisha, using large scale sample survey data, employing machine learning models. Methods We analysed data from 19,703 adults across 53 indigenous communities enrolled in the Odisha Tribal Family Health Survey (OTFHS, 2022-23). Data were collected with serum creatinine, from which estimated glomerular filtration rate (eGFR) was derived using chronic kidney disease epidemiology collaboration equation (CKD-EPI). Impaired kidney function (IKF) was defined as eGFR <90 mL/min/1.73m2 and classified into mild, moderate, severe, and failure categories. Deep neural network (DNN) and eXtreme gradient boosting (XGBoost) models were developed for early prediction for IKF. Results Overall, 24.8% [95% confidence interval (CI): 23.8-25.9] of participants had IKF: 16.6% mild, 6.4% moderate, 1.5% severe, and 0.3% kidney failure. The prevalence increased with age (5.6% in 18-30 y vs. 79.4% in >70 y) and was higher among men, those with lower education, tobacco or alcohol use, and individuals with hypertension, diabetes, or underweight. The DNN model showed good predictive performance (accuracy 0.78; recall 0.69), with improved recall (0.78) at a threshold of 0.4. Decision curve analysis suggested a potential benefit of machine learning (ML) based targeted screening. Shapley Additive explanations (SHAP) analysis identified age, hypertension, diabetes, tobacco use, alcohol use, and low dietary diversity as key predictors. Interpretations and conclusions Nearly one in four adults from indigenous communities in Odisha had IKF, highlighting a substantial and inequitable kidney disease burden. Machine learning models using routine data offer a feasible strategy for early detection and targeted interventions in resource-limited indigenous settings. FAU - Kshatri, Jaya Singh AU - Kshatri JS AD - ICMR-National Institute of Health Research, Bhubaneswar, Odisha, India. AD - Model Rural Health Research Unit, Sheragada, Ganjam, Odisha, India. AD - Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands. FAU - Deo, Vishal AU - Deo V AD - ICMR-National Institute for Research in Digital Health, New Delhi, India. FAU - A K, Kavitha AU - A K K AD - ICMR-National Institute of Health Research, Bhubaneswar, Odisha, India. AD - Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands. FAU - Rehman, Tanveer AU - Rehman T AD - ICMR-National Institute of Health Research, Bhubaneswar, Odisha, India. FAU - Jha, Vivekananda AU - Jha V AD - The George Institute for Global Health, New Delhi, India. FAU - Pati, Sanghamitra AU - Pati S AD - ICMR-National Institute of Health Research, Bhubaneswar, Odisha, India. AD - Indian Council of Medical Research, New Delhi, India. LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - India/epidemiology MH - Male MH - Adult MH - Risk Factors MH - Glomerular Filtration Rate/physiology MH - Prevalence MH - *Renal Insufficiency, Chronic/epidemiology/physiopathology/diagnosis MH - Middle Aged MH - Female MH - Adolescent MH - Predictive Learning Models MH - Creatinine/blood MH - Young Adult PMC - PMC13650849 OTO - NOTNLM OT - Chronic kidney disease OT - Impaired kidney function OT - Indigenous health OT - Machine learning OT - OTFHS COIS- None. EDAT- 2026/10/09 05:30 MHDA- 2026/10/09 05:31 PMCR- 2026/10/01 CRDT- 2026/10/09 04:21 PHST- 2026/02/08 00:00 [received] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/10/09 05:31 [medline] PHST- 2026/10/09 05:30 [pubmed] PHST- 2026/10/09 04:21 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.25259/IJMR_491_2026 [pii] AID - 10.25259/IJMR_491_2026 [doi] PST - ppublish SO - Indian J Med Res. 2026 Aug;164(4):621-629. doi: 10.25259/IJMR_491_2026. PMID- 42850777 OWN - NLM STAT- Publisher LR - 20261009 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) DP - 2026 Oct 8 TI - Diagnostic accuracy of gastric aspirate pH measurement for verifying nasogastric tube placement in children receiving home enteral nutrition: An observational diagnostic accuracy study. LID - 10.1002/ncp.70185 [doi] AB - BACKGROUND: Accurate verification of nasogastric (NG) tube placement is essential to prevent complications. Although radiography remains the reference standard, repeated imaging is impractical for children receiving home enteral nutrition. Gastric aspirate pH measurement is recommended as the preferred bedside method, but evidence of its diagnostic accuracy in pediatric home care is limited. METHODS: This observational diagnostic accuracy study included 40 children receiving home enteral nutrition via NG tubes. Gastric aspirate pH was measured once immediately before a fluoroscopic swallowing assessment scheduled as part of routine care. Standardized pH indicator strips were used, and fluoroscopic findings served as the reference standard. Receiver operating characteristic (ROC) analysis was performed to identify a sample-derived optimal pH cutoff. RESULTS: Fluoroscopy confirmed gastric placement in 27 children (67.5%) and nongastric placement in 13 (32.5%), including high and duodenal tube positions. Gastric pH values were lower than those in nongastric placements (P < 0.001). ROC analysis identified a sample-derived cutoff of 5.65. At the prespecified internationally recommended clinical threshold of /= .19). However, PA temporally close to sleep had a rapid eye movement (REM) sleep-suppressing effect: each additional hour between PA and sleep onset decreased REM latency by 1.8 minutes (B = -1.82, SE = 0.58, P = .002) and increased REM percentage by 0.30 percentage points (B = 0.30, SE = 0.11, P = .008), but no other timing effect was found. Results were robust across multiple analytical specifications. CONCLUSIONS: Our results support neither a general sleep-promoting effect of PA nor a sleep-suppressing effect of EPA and suggest that for healthy young individuals, habitual, relatively low-intensity EPA is safe to perform and is a good alternative for those whose daily schedule permits no alternative timing, although the lack of detailed exercise intensity monitoring is a limitation of our study. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Society of Behavioral Medicine. FAU - Wolf, Sara AU - Wolf S AUID- ORCID: 0009-0003-1060-6049 AD - Institute of Behavioural Sciences, Semmelweis University, Nagyvarad ter 4., Budapest H-1089, Hungary. FAU - Bodizs, Robert AU - Bodizs R AUID- ORCID: 0000-0001-5341-060X AD - Institute of Behavioural Sciences, Semmelweis University, Nagyvarad ter 4., Budapest H-1089, Hungary. FAU - Ujma, Peter Przemyslaw AU - Ujma PP AUID- ORCID: 0009-0007-6880-8064 AD - Institute of Behavioural Sciences, Semmelweis University, Nagyvarad ter 4., Budapest H-1089, Hungary. LA - eng GR - CELSA/24/019/Central Europe Leuven Strategic Alliance/ GR - 138935/National Research, Development and Innovation Office-NKFIH/ GR - Hungarian Academy of Sciences/ PT - Journal Article PT - Observational Study PL - England TA - Ann Behav Med JT - Annals of behavioral medicine : a publication of the Society of Behavioral Medicine JID - 8510246 SB - IM MH - Humans MH - Female MH - *Exercise/physiology MH - Adult MH - Young Adult MH - Male MH - Electroencephalography MH - *Sleep/physiology MH - *Sleep, REM/physiology MH - Adolescent MH - Sleep Duration PMC - PMC13215084 OAB - General sleep hygiene advice is to avoid exercising in the evening, because it might worsen sleep quality. However, scientific evidence about the topic is mixed. We examined how physical activity and its timing relate to sleep quality in healthy young adults. Participants were monitored for multiple days in their homes. Physical activity was reported daily, and sleep was measured using a headband that records brain activity, allowing a detailed assessment of sleep structure. This approach allows us to study this relationship in participants' natural environment and provides more precise sleep measurements than movement-based trackers or self-reports used in previous studies. We found that daily physical activity had minimal effects on sleep quality or structure. Even when people reported evening physical activity, it was not associated with major sleep disruption. However, activity performed nearer to sleep onset was linked to a modest reduction in rapid eye movement sleep, a stage associated with dreaming. This is likely because this stage is particularly sensitive to the physiological effects of exercise. Based on these findings, evening physical activity is generally safe to perform. A limitation of our study is that it only investigated the effects of habitual exercise on healthy young adults. OABL- eng OTO - NOTNLM OT - BSETS OT - exercise OT - mobile EEG OT - multiday observational study OT - physical activity OT - sleep COIS- The authors declare that they have no conflict of interest. EDAT- 2026/10/08 17:35 MHDA- 2026/10/08 17:36 PMCR- 2026/05/27 CRDT- 2026/10/08 15:14 PHST- 2025/10/22 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/10/08 17:36 [medline] PHST- 2026/10/08 17:35 [pubmed] PHST- 2026/10/08 15:14 [entrez] PHST- 2026/05/27 00:00 [pmc-release] AID - 8696183 [pii] AID - kaag025 [pii] AID - 10.1093/abm/kaag025 [doi] PST - ppublish SO - Ann Behav Med. 2026 Jan 7;60(1):kaag025. doi: 10.1093/abm/kaag025. PMID- 42847363 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261020 IS - 1532-4796 (Electronic) IS - 0883-6612 (Print) IS - 0883-6612 (Linking) VI - 60 IP - 1 DP - 2026 Jan 7 TI - Vices and vegetables: a systematic review and series of meta-analyses examining the relationships among compensatory health beliefs with health-related intentions and behaviors. LID - 10.1093/abm/kaag013 [doi] LID - kaag013 AB - BACKGROUND: Compensatory health beliefs (CHBs), the belief that a healthy behavior can offset the effects of a health-compromising one, have been theorized to both justify unhealthy behaviors and motivate health-promoting ones. However, findings in the literature are inconsistent. METHODS: These meta-analyses synthesized 252 effect sizes from 59 independent samples using robust variance estimation to examine the relationships between CHBs and four outcomes: intentions and engagement in compensatory health behaviors and intentions and engagement in health-compromising behaviors. RESULTS: Approximately 13,760 individuals were represented across these analyses (ages 12-79; women approximately 66.1%; college-based = 69.8%). CHBs were significantly associated with greater intentions to engage in compensatory health behaviors (r = 0.21) and with greater engagement in health-compromising behaviors (r = 0.18), but were not reliably associated with compensatory health behaviors or intentions to engage in health-compromising behaviors. Heterogeneity was substantial across all models, but only one significant moderator emerged: CHBs were more strongly associated with compensatory intentions in studies examining diet compared to physical activity. Funnel plot symmetry and stability across values of rho supported the robustness of findings. CONCLUSIONS: These results highlight the potential for CHBs to undermine health behavior change efforts, particularly when intentions to engage in healthy behaviors are not carried out. Future work should explore state-level CHBs and real-time decision-making to clarify how and when these beliefs influence behavior. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Society of Behavioral Medicine. FAU - Fox, Gavin Q AU - Fox GQ AUID- ORCID: 0009-0008-0732-7723 AD - Department of Psychology, Lehigh University, Bethlehem, PA 18015, United States. AD - Health, Medicine, and Society Program, Lehigh University, Bethlehem, PA 18015, United States. FAU - Luong, Minh Quang AU - Luong MQ AUID- ORCID: 0009-0009-6861-4301 AD - Department of Psychology, Lehigh University, Bethlehem, PA 18015, United States. FAU - Kimmel, Allison AU - Kimmel A AUID- ORCID: 0009-0001-2908-4186 AD - Department of Psychology, Lehigh University, Bethlehem, PA 18015, United States. FAU - Napper, Lucy E AU - Napper LE AUID- ORCID: 0000-0002-2510-3407 AD - Department of Psychology, Lehigh University, Bethlehem, PA 18015, United States. AD - Health, Medicine, and Society Program, Lehigh University, Bethlehem, PA 18015, United States. LA - eng GR - Dean's Fellowship from the College of Arts and Sciences at Lehigh University/ GR - Lehigh University's Health/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review PL - England TA - Ann Behav Med JT - Annals of behavioral medicine : a publication of the Society of Behavioral Medicine JID - 8510246 SB - IM MH - Humans MH - *Health Behavior MH - *Intention MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Adolescent MH - Adult MH - Middle Aged MH - Aged PMC - PMC13092134 OAB - One common response to encountering tempting situations (eg, seeing a box of donuts) is to activate compensatory health beliefs (CHBs), or beliefs that the negative effects of an unhealthy behavior (eg, eating a donut) can be compensated by carrying out a healthy behavior (eg, exercising). Past research examining how CHBs are related to motivation and performance of health behaviors has produced mixed results. The current study aims to understand the impact of CHBs by synthesizing findings from across nearly 60 studies, including over 250 effects. Results showed that, on average, CHBs are positively associated with engagement in unhealthy behaviors but are not associated with motivation to engage in these behaviors. Conversely, CHBs are positively associated with motivation to engage in healthy behaviors but are not associated with actual engagement in those healthy behaviors. In addition, the positive relationship between CHBs and motivation to engage in healthy behaviors was stronger in the context of diet compared to physical activity behaviors. These findings suggest that interventions could promote multiple health behavior changes by correcting people's misperceptions about the usefulness of compensating for unhealthy behaviors and creating specific plans for when/where/how one will carry out a healthy behavior. OABL- eng OTO - NOTNLM OT - compensatory behavior OT - compensatory health beliefs (CHBs) OT - health behavior OT - intentions OT - justification OT - meta-analysis COIS- The authors of this paper declare no conflicting interests. EDAT- 2026/10/08 17:35 MHDA- 2026/10/08 17:36 PMCR- 2026/04/19 CRDT- 2026/10/08 15:14 PHST- 2025/09/25 00:00 [received] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/10/08 17:36 [medline] PHST- 2026/10/08 17:35 [pubmed] PHST- 2026/10/08 15:14 [entrez] PHST- 2026/04/19 00:00 [pmc-release] AID - 8658837 [pii] AID - kaag013 [pii] AID - 10.1093/abm/kaag013 [doi] PST - ppublish SO - Ann Behav Med. 2026 Jan 7;60(1):kaag013. doi: 10.1093/abm/kaag013. PMID- 42847041 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261008 LR - 20261010 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 51 IP - 5 DP - 2026 Sep-Oct TI - Enhancing Successful Breastfeeding: A Skill-based Education Intervention for First-Time Mothers. PG - 792-800 LID - 10.4103/ijcm.ijcm_697_25 [doi] AB - BACKGROUND: Breastfeeding provides optimal nutrition and immune protection for newborns; however, in India and other low- and middleincome countries, only about half of infants are breastfed within the first hour of birth, making initiation and continuation challenging. This study assessed the effectiveness of a skill-based group education module on breastfeeding among primiparous women in the third trimester in establishing successful breastfeeding. MATERIALS AND METHODS: A quasirandomized controlled trial was conducted from December 2023 to May 2024 in the inpatient and outpatient departments of AIIMS Rishikesh and SPS Hospital. Primiparous women in the third trimester were allocated day-wise to either the intervention or control group. The intervention group received a validated skill-based breastfeeding education session supplemented with WhatsApp support and routine antenatal care (ANC), while the control group received routine ANC alone. Data on breastfeeding knowledge, attitude, early initiation of breastfeeding (EIBF), breastfeeding self-efficacy (BFSEF), and challenges were collected before and after the intervention. RESULTS: The intervention group demonstrated a significant improvement in knowledge scores, increasing from a prepartum mean of 3.12 (SD (standard deviation) =0.87) to 7.93 (SD = 0.25) postdelivery, with a mean difference of 4.81 (SD = 0.90). Although the proportion of EIBF was higher in the intervention group, the difference was not statistically significant after adjustment for baseline knowledge. The overall mean breastfeeding success score was higher in the intervention group (16.13, SD = 1.15) compared with the control group (15.35, SD = 1.15). BFSEF was also significantly higher in the intervention group (45.36, SD = 3.98) than in the control group (40.71, SD = 4.05). CONCLUSIONS: Skill-based breastfeeding education significantly improved maternal knowledge, components of successful breastfeeding, and selfefficacy. Although EIBF rates did not differ significantly, the intervention enhanced preparedness and confidence among firsttime mothers. TRAIL REGISTRATION: CTRI/2024/02/063346 (Clinical trial registry of India registered on February 29, 2024. First patient recruited on March 29, 2024). CI - Copyright: (c) 2026 Indian Journal of Community Medicine. FAU - Diksha, D AU - Diksha D AD - Department of Community Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. FAU - Khapre, Meenakshi AU - Khapre M AD - Department of Community Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. FAU - Chawla, Latika AU - Chawla L AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. FAU - Sinha, Smita AU - Sinha S AD - Department of Community Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. FAU - Jain, Nishit AU - Jain N AD - Department of General Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. LA - eng PT - Journal Article DEP - 20260918 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC13645129 OTO - NOTNLM OT - Breastfeeding OT - prenatal education OT - self-efficacy OT - successful breastfeeding COIS- There are no conflicts of interest. EDAT- 2026/10/08 17:35 MHDA- 2026/10/08 17:36 PMCR- 2026/09/01 CRDT- 2026/10/08 14:57 PHST- 2025/09/12 00:00 [received] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/10/08 17:36 [medline] PHST- 2026/10/08 17:35 [pubmed] PHST- 2026/10/08 14:57 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - IJCM-51-792 [pii] AID - 10.4103/ijcm.ijcm_697_25 [doi] PST - ppublish SO - Indian J Community Med. 2026 Sep-Oct;51(5):792-800. doi: 10.4103/ijcm.ijcm_697_25. Epub 2026 Sep 18. PMID- 42846299 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261008 LR - 20261010 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - An interpretable machine-learning model identifies obesity-related metabolic complications in children attending a tertiary obesity clinic. PG - 1969179 LID - 10.3389/fped.2026.1969179 [doi] LID - 1969179 AB - Childhood obesity-related metabolic complications are common in Northwest China, yet region-specific evidence and risk-stratification tools are lacking. In a single-visit cross-sectional study of 131 children (3-18 years) with overweight or obesity attending a Gansu maternal and child-care hospital, obesity-related metabolic complications (ORMC) were present in 31.3% (dyslipidaemia 16.0%, hyperuricaemia 9.2%, elevated blood pressure 7.6%). An interpretable model combining LASSO-selected adiposity measures (body mass index, neck circumference, body fat percentage) with penalised logistic regression achieved moderate, internally cross-validated discrimination (AUC 0.72, 95% CI 0.62-0.82) that awaits external validation, comparable to a random forest (0.73). Screen time was the strongest modifiable behavioural correlate. Routine metabolic screening and simple body-composition measures should be embedded in paediatric obesity clinics, with screen-time reduction as a counselling priority. CI - (c) 2026 Li, Nan, Wei, Zhu, Li, Zhang, Wang, Da, Chai, Wang and Xie. FAU - Li, Tingting AU - Li T AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Nan, Nan AU - Nan N AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Wei, Wenjie AU - Wei W AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Zhu, Ying AU - Zhu Y AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Li, Jiayue AU - Li J AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Zhang, Lingzhi AU - Zhang L AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Wang, Bingwu AU - Wang B AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Da, Zhenqiang AU - Da Z AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Chai, Jiaxin AU - Chai J AD - School of Cyberspace Security, Gansu University of Political Science and Law, Lanzhou, Gansu, China. FAU - Wang, Cheng AU - Wang C AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Xie, Xingwen AU - Xie X AD - Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, Gansu, China. LA - eng PT - Journal Article DEP - 20260923 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13642582 OTO - NOTNLM OT - LASSO OT - body composition OT - childhood obesity OT - machine learning OT - metabolic complications OT - risk prediction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/08 17:35 MHDA- 2026/10/08 17:36 PMCR- 2026/09/23 CRDT- 2026/10/08 11:46 PHST- 2026/08/16 00:00 [received] PHST- 2026/09/02 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/08 17:36 [medline] PHST- 2026/10/08 17:35 [pubmed] PHST- 2026/10/08 11:46 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 10.3389/fped.2026.1969179 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 23;14:1969179. doi: 10.3389/fped.2026.1969179. eCollection 2026. PMID- 42846167 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Development and validation of an interpretable machine learning model for predicting ADHD comorbidity in children with allergic rhinitis: a SHAP-based analysis. PG - 1837156 LID - 10.3389/fpubh.2026.1837156 [doi] LID - 1837156 AB - BACKGROUND: The co-occurrence of allergic rhinitis (AR) and attention-deficit/hyperactivity disorder (ADHD) presents significant clinical challenges in pediatrics, yet predictive tools capturing non-linear neuro-immune interactions are lacking. METHODS: We developed an interpretable Extreme Gradient Boosting (XGBoost) model utilizing a hybrid feature selection pipeline on a cohort of 518 pediatric AR patients (255 with comorbid ADHD). Model performance was evaluated via an independent test set. Global and local interpretability was decoded using SHapley Additive exPlanations (SHAP). RESULTS: A parsimonious subset of six predictors was identified. The XGBoost model achieved superior discriminative capacity (AUC = 0.878) compared to conventional linear baselines. SHAP topographical analysis revealed profound non-linear thresholds and uncovered a critical synergistic interaction: elevated ADHD risk was strongly correlated with patients presenting simultaneously severe allergic inflammation (Total IgE > 250 IU/mL) and nutritional deficiency (Vitamin D < 20 ng/mL). Furthermore, Decision Curve Analysis (DCA) demonstrated substantial net clinical benefit for triage application. CONCLUSION: We established a highly robust, interpretable machine learning algorithm capable of accurately stratifying ADHD risk among AR children. The identified neuro-immune synergistic phenotypes provide critical mechanistic insights and offer a practical decision-support tool for timely pediatric multidisciplinary interventions. CI - Copyright (c) 2026 Yuan and Wu. FAU - Yuan, Hexiu AU - Yuan H AD - Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China. FAU - Wu, Nengjing AU - Wu N AD - First Affiliated Hospital of Gannan Medical University, Ganzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260923 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/epidemiology MH - *Rhinitis, Allergic/epidemiology MH - Comorbidity MH - Child MH - Boosting Machine Learning Algorithms MH - Female MH - Predictive Learning Models MH - *Machine Learning MH - Male MH - Adolescent PMC - PMC13642325 OTO - NOTNLM OT - SHAP OT - allergic rhinitis OT - attention-deficit/hyperactivity disorder OT - machine learning OT - neuro-immune crosstalk COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/08 17:35 MHDA- 2026/10/08 17:36 PMCR- 2026/09/23 CRDT- 2026/10/08 11:06 PHST- 2026/03/23 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/08 17:36 [medline] PHST- 2026/10/08 17:35 [pubmed] PHST- 2026/10/08 11:06 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1837156 [doi] PST - epublish SO - Front Public Health. 2026 Sep 23;14:1837156. doi: 10.3389/fpubh.2026.1837156. eCollection 2026. PMID- 42845756 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261009 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Digital health literacy moderates the school sports environment and physical activity pathway among Chinese adolescents: a health equity perspective. PG - 1967478 LID - 10.3389/fpubh.2026.1967478 [doi] LID - 1967478 AB - BACKGROUND: Physical inactivity among Chinese adolescents remains a pressing public health concern, with pronounced urban-rural disparities. School sports environments serve as a critical determinant of adolescent physical activity (PA), yet the conditions under which this relationship strengthens or weakens remain insufficiently understood. Digital health literacy (DHL) has emerged as a potential moderator that may amplify or buffer environmental influences on PA behavior. METHODS: A cross-sectional survey was conducted among 2,531 adolescents (M(age) = 15.2 +/- 1.8 years; 51.3% male) recruited through stratified cluster sampling from 18 secondary schools in Hubei Province, China (9 urban, 9 rural). Participants completed validated Chinese versions of the Questionnaire Assessing School Physical Activity Environment (Q-SPACE-Chi), the eHealth Literacy Scale (eHEALS), and the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Structural equation modeling with a latent interaction term tested the moderating role of DHL, and multigroup analysis examined urban-rural differences. Reporting followed the STROBE guideline. RESULTS: School sports environment was positively associated with PA levels (beta = 0.34, p < 0.001). DHL significantly moderated this pathway (interaction beta = 0.12, p = 0.003), such that the environment-PA association was stronger among adolescents with higher DHL. Multigroup analysis revealed a significantly stronger environmental effect in urban (beta = 0.38) than in rural schools (beta = 0.29; z = 2.87, p = 0.004); the DHL moderation was significant in urban (beta = 0.14, p = 0.008) but not rural schools (beta = 0.07, p = 0.14), and the between-group difference in the moderation effect was not significant (z = 0.99, p = 0.32). The model demonstrated acceptable fit (chi (2)/df = 3.12, CFI = 0.94, TLI = 0.93, RMSEA = 0.045, SRMR = 0.041). CONCLUSION: DHL amplifies the translation of favorable school sports environments into actual PA engagement, and the environment-PA association was stronger in urban schools. These findings suggest a potential pathway through which digital inequities may contribute to PA disparities, a possibility that requires longitudinal confirmation, and underscore the need for integrated school-based and digital literacy interventions to advance health equity. CI - Copyright (c) 2026 Zhang. FAU - Zhang, Bing AU - Zhang B AD - School of Physical Education, Huanggang Normal University, Huanggang, Hubei, China. LA - eng PT - Journal Article DEP - 20260923 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Male MH - China MH - Cross-Sectional Studies MH - *Health Literacy/statistics & numerical data MH - Female MH - *Schools MH - *Exercise MH - *Sports MH - Digital Health MH - Surveys and Questionnaires MH - *Health Equity MH - Rural Population/statistics & numerical data MH - Urban Population/statistics & numerical data PMC - PMC13642271 OTO - NOTNLM OT - adolescents OT - digital health literacy OT - health equity OT - physical activity OT - school sports environment OT - social ecological model OT - urban-rural disparity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/08 11:39 MHDA- 2026/10/08 11:40 PMCR- 2026/09/23 CRDT- 2026/10/08 08:26 PHST- 2026/08/14 00:00 [received] PHST- 2026/09/05 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/08 11:40 [medline] PHST- 2026/10/08 11:39 [pubmed] PHST- 2026/10/08 08:26 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1967478 [doi] PST - epublish SO - Front Public Health. 2026 Sep 23;14:1967478. doi: 10.3389/fpubh.2026.1967478. eCollection 2026. PMID- 42845237 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 1949-0984 (Electronic) IS - 1949-0976 (Print) IS - 1949-0976 (Linking) VI - 18 IP - 1 DP - 2026 Dec 31 TI - Gut microbial metabolism of peanuts generates immunoregulatory metabolites. PG - 2743944 LID - 10.1080/19490976.2026.2743944 [doi] LID - 2743944 AB - Early life introduction of potentially allergenic foods such as peanuts is important for the prevention of food allergy. We hypothesized that peanut consumption may indirectly influence the immune system via effects on gut microbiota composition and metabolism. In vitro human fecal fermentations with peanuts were performed. Changes in taxa and metabolism were measured using 16S rRNA gene sequencing and untargeted metabolomics respectively. Ten Bifidobacterium strains were cultured in vitro in the presence of peanuts and human peripheral blood mononuclear cells (PBMCs) were used to assess culture supernatant immunomodulatory effects. Fecal samples were sequenced from children at 12 months (n = 343) using whole genome metagenomic sequencing. An online questionnaire was used to collect dietary data. Human fecal bioreactor fermentation of peanut flour, previously subjected to in vitro simulated gastrointestinal digestion, resulted in significant production of short-chain fatty acids (SCFA), associated with increased relative abundance of Megasphaera and bifidobacteria. 188 metabolites were significantly altered following peanut fermentation. Bifidobacterium longum subspecies longum strain 160 efficiently metabolized peanut associated with secretion of indole-3-lactic acid (ILA). Following growth on peanuts, bifidobacterial supernatants enhanced IL-10 secretion, but reduced TNF-alpha and IL-5 secretion from stimulated PBMCs. Peanut consumption by 12-month-old children was associated with significant changes in gut microbiota composition including increased levels of Prevotella buccae, Megasphaera micronuciformis and Blautia wexlerae. Peanuts are metabolized by microbes generating immunoregulatory metabolites such as SCFAs and ILA. These metabolites may represent one potential mechanism underlying the allergy-protective effects of early peanut consumption, which requires further validation in high-risk allergy cohorts. FAU - Shannon, Emer AU - Shannon E AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Devotta, Hannah AU - Devotta H AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Ndwandwe, Cebile AU - Ndwandwe C AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Kim, Songhui AU - Kim S AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Yao, Lu AU - Yao L AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Kareem, Lamiah AU - Kareem L AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Walters, Avril AU - Walters A AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Korpela, Katri AU - Korpela K AUID- ORCID: 0000-0001-5031-2713 AD - Department of Bacteriology and Immunology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Hurley, Sadhbh AU - Hurley S AD - Department of Paediatrics, Cork University Hospital, University College Cork, Cork, Ireland. FAU - Lunjani, Nonhlanhla AU - Lunjani N AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - University of Cape Town, Cape Town, South Africa. FAU - Koc, Fatma AU - Koc F AD - Teagasc Food Research Centre, Fermoy, Ireland. FAU - Mathur, Harsh AU - Mathur H AD - Teagasc Food Research Centre, Fermoy, Ireland. FAU - Ambikan, Anoop AU - Ambikan A AD - The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Stockholm, Sweden. FAU - Neogi, Ujjwal AU - Neogi U AD - The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Stockholm, Sweden. FAU - Friess, Lisa AU - Friess L AUID- ORCID: 0000-0001-7945-2875 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - van Sinderen, Douwe AU - van Sinderen D AUID- ORCID: 0000-0003-1823-7957 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Stanton, Catherine AU - Stanton C AUID- ORCID: 0000-0002-6724-7011 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - Teagasc Food Research Centre, Fermoy, Ireland. FAU - Venter, Carina AU - Venter C AD - Section of Allergy & Immunology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA. FAU - Walter, Jens AU - Walter J AUID- ORCID: 0000-0003-1754-172X AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. AD - Department of Medicine, University College Cork, Cork, Ireland. FAU - Hourihane, Jonathan AU - Hourihane J AD - Paediatrics and Child Health, Royal College of Surgeons in Ireland, Dublin, Ireland. AD - Children's Health Ireland, Dublin, Ireland. FAU - O'Mahony, Liam AU - O'Mahony L AUID- ORCID: 0000-0003-4705-3583 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. AD - Department of Medicine, University College Cork, Cork, Ireland. LA - eng PT - Journal Article DEP - 20261008 PL - United States TA - Gut Microbes JT - Gut microbes JID - 101495343 RN - 5SW11R7M7M (indole-3-lactic acid) RN - 0 (Fatty Acids, Volatile) RN - 0 (Indoles) SB - IM MH - *Gastrointestinal Microbiome/immunology MH - *Arachis/immunology/metabolism MH - Feces/microbiology MH - Immune Tolerance MH - *Peanut Hypersensitivity/microbiology/prevention & control MH - Fermentation MH - Bifidobacterium/metabolism MH - Humans MH - Infant MH - Fatty Acids, Volatile/metabolism MH - Indoles PMC - PMC13652054 OTO - NOTNLM OT - Microbiota OT - allergy OT - complementary feeding OT - infants OT - peanuts COIS- C. Venter reports research grants from Reckitt, and Global parents for eczema research, and contributed to speakers' bureau for Reckitt, Nestle Nutrition Institute, Novalac, Danone and Abbott Nutrition. L. O'Mahony reports research grants from Chiesi, Reckitt and Fonterra, and participation in speaker bureau for Nestle, Yakult, Reckitt and Abbott. J. Hourihane is a board member of Clemens Von Pirquet Foundation and receives research funding and speaker fees from DBV Technologies and research funding from City of Dublin Skin and Cancer Hospital Charity and Kenvue. C. Stanton reports research grants from Nestle and IFF. U. Neogi received travel support from Olink Ab, Sweden. No potential conflicts of interest were disclosed for the remaining authors. EDAT- 2026/10/08 11:39 MHDA- 2026/10/08 11:40 PMCR- 2026/10/08 CRDT- 2026/10/08 05:10 PHST- 2026/10/08 11:40 [medline] PHST- 2026/10/08 11:39 [pubmed] PHST- 2026/10/08 05:10 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 2743944 [pii] AID - 10.1080/19490976.2026.2743944 [doi] PST - ppublish SO - Gut Microbes. 2026 Dec 31;18(1):2743944. doi: 10.1080/19490976.2026.2743944. Epub 2026 Oct 8. PMID- 42845143 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 37 IP - 10 DP - 2026 Oct TI - Machine learning-based prediction of food sensitization in infants and toddlers with atopic dermatitis. PG - e70518 LID - 10.1111/pai.70518 [doi] AB - BACKGROUND: Food sensitization (FS) is a common comorbidity in children with atopic dermatitis (AD), often leading to the atopic march. Identifying high-risk patients in primary care is crucial to prioritize specialist referrals and prevent unnecessary elimination diets. OBJECTIVE: To develop and validate a machine learning (ML) based clinical decision support tool to predict IgE-mediated FS risk in infants and toddlers (0-3 years) diagnosed with AD using routine clinical and laboratory parameters. METHODS: We conducted a retrospective cohort study of children diagnosed with AD. Patients were classified as FS positive or FS negative based on specific IgE levels and skin prick tests. Ten ML algorithms were trained and compared using 5-fold stratified cross-validation. Feature importance was analyzed, and an interactive web-based tool was developed for clinical application. RESULTS: Among 340 patients, 156 (45.8%) had IgE-mediated FS. Key independent predictors of FS included higher total IgE levels, younger age at presentation, elevated eosinophil counts, and breastfeeding at the time of symptom onset. Boosting-based models achieved superior performance; specifically, the AdaBoost model demonstrated high stability and discrimination (ROC AUC: 0.815 in CV and 0.819 in the held-out test set). By optimizing the probability threshold to 0.40, the model achieved a recall of 92% and an F1-score of 0.75, effectively minimizing false negatives. CONCLUSION: The ML model may serve as a screening and risk-stratification tool for IgE-mediated FS in children with AD. By utilizing routine laboratory data, this web-integrated tool can support primary care physicians in risk stratification, ensuring timely referral for high-risk cases while reducing unnecessary testing in low-risk infants. CI - (c) 2026 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Yildirim, Riza AU - Yildirim R AUID- ORCID: 0009-0000-2675-1150 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Senbaykal Yigit, Ece AU - Senbaykal Yigit E AUID- ORCID: 0000-0001-6927-1261 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Safak, Ikbal Nur AU - Safak IN AUID- ORCID: 0000-0002-2748-4274 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Demirtas, Hatemi Esam AU - Demirtas HE AUID- ORCID: 0009-0005-4377-3710 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Pakel, Ayse AU - Pakel A AUID- ORCID: 0000-0002-4422-7595 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Tunca, Seda AU - Tunca S AUID- ORCID: 0000-0003-3193-1062 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Eren Akarcan, Sanem AU - Eren Akarcan S AUID- ORCID: 0000-0002-2170-765X AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Akay Haci, Idil AU - Akay Haci I AUID- ORCID: 0000-0002-0965-0726 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Taskirdi, Ilke AU - Taskirdi I AUID- ORCID: 0000-0001-9326-2541 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey. FAU - Tuncel, Tuba AU - Tuncel T AUID- ORCID: 0000-0002-9377-6750 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey. LA - eng PT - Journal Article PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - Infant MH - *Dermatitis, Atopic/diagnosis/immunology/epidemiology MH - Child, Preschool MH - Male MH - Female MH - *Food Hypersensitivity/diagnosis/epidemiology/immunology MH - Immunoglobulin E/blood MH - Retrospective Studies MH - *Machine Learning MH - Predictive Learning Models MH - Infant, Newborn MH - Skin Tests MH - Boosting Machine Learning Algorithms MH - Classification Algorithms MH - Prediction Algorithms OTO - NOTNLM OT - atopic dermatitis OT - children OT - food sensitization OT - machine learning OT - risk stratification EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:32 CRDT- 2026/10/08 04:12 PHST- 2026/09/16 00:00 [revised] PHST- 2026/05/13 00:00 [received] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/08 05:32 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 04:12 [entrez] AID - 10.1111/pai.70518 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 Oct;37(10):e70518. doi: 10.1111/pai.70518. PMID- 42845016 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1532-2998 (Electronic) IS - 1532-3005 (Linking) VI - 42 IP - 5 DP - 2026 Oct TI - Decoding the Anxiety Burden in Asia and Developing an XGBoost-Based Online Screening Tool Using Korean Data. PG - e70231 LID - 10.1002/smi.70231 [doi] AB - Anxiety disorders impose a substantial burden across Asia, yet comprehensive regional surveillance remains limited. In addition, the utility of the Health-Related Quality of Life Instrument with 8 Items (HINT-8) for anxiety screening in the Korean population has not been fully clarified. This study integrated data from Global Burden of Disease (GBD) 2021 and Korea National Health and Nutrition Examination Survey (KNHANES) to comprehensively assess the prevalence, incidence, and disability-adjusted life year (DALY) rates of Anxiety disorders across 48 Asian countries and territories from 1990 to 2021. Joinpoint regression, age-period-cohort modelling, decomposition analysis, and health inequality indices were employed to analyse trends and driving factors. In the Korean dataset, eight machine learning algorithms were compared. SHAP analysis was used to interpret the results, and the best-performing model was ultimately developed into an online prediction model. In 2021, Asia accounted for over half of global anxiety cases, and age-standardized rates increased by 14.6%-17.1% since 1990. After 2019, incidence (APC = 9.532%) and DALY rates (APC = 9.157%) rose sharply. Burden patterns varied by sex and age, and population growth was a major driver. In the Korean dataset, XGBoost showed the best performance (AUC = 0.894). An 8-feature parsimonious model performed comparably to the 17-feature model while improving interpretability and practical feasibility. Asia's growing anxiety burden demands prioritised care for women, adolescents, and middle-aged populations and better crisis mental health services. A Korean machine-learning tool shows potential but requires broader Asian validation. CI - (c) 2026 John Wiley & Sons Ltd. All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies. FAU - Cao, Runmin AU - Cao R AUID- ORCID: 0000-0002-8173-2961 AD - Clinical Medical College, Jinzhou Medical University, Jinzhou, Liaoning Province, China. FAU - Zhang, Yurun AU - Zhang Y AUID- ORCID: 0009-0008-7335-9272 AD - Rehabilitation Therapy, Shandong XIANDAI University, Jinan City, Shandong Province, China. FAU - Cao, Ling AU - Cao L AD - Jieshou City Center for Disease Control and Prevention, Fuyang City, Anhui Province, China. FAU - Jiang, Honghe AU - Jiang H AUID- ORCID: 0009-0007-3799-7202 AD - Department of Clinical Medicine, Anhui University of Science and Technology, Huainan City, Anhui Province, China. LA - eng PT - Journal Article PL - England TA - Stress Health JT - Stress and health : journal of the International Society for the Investigation of Stress JID - 101089166 SB - IM MH - Humans MH - Female MH - Republic of Korea/epidemiology MH - *Anxiety Disorders/epidemiology/diagnosis MH - Middle Aged MH - Adult MH - Male MH - Boosting Machine Learning Algorithms MH - Incidence MH - Prevalence MH - Asia/epidemiology MH - Nutrition Surveys MH - *Mass Screening/methods MH - Aged MH - Disability-Adjusted Life Years MH - Quality of Life OTO - NOTNLM OT - Asian burden of disease OT - Korean cohort OT - anxiety disorders OT - machine learning EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:32 CRDT- 2026/10/08 03:14 PHST- 2026/07/13 00:00 [revised] PHST- 2026/01/30 00:00 [received] PHST- 2026/10/01 00:00 [accepted] PHST- 2026/10/08 05:32 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 03:14 [entrez] AID - 10.1002/smi.70231 [doi] PST - ppublish SO - Stress Health. 2026 Oct;42(5):e70231. doi: 10.1002/smi.70231. PMID- 42845011 OWN - NLM STAT- Publisher LR - 20261008 IS - 1532-530X (Electronic) IS - 1064-0266 (Linking) DP - 2026 Oct 8 TI - Development and early implementation of a brief 2-day multidisciplinary parent training group for paediatric ARFID: A feasibility and acceptability study. PG - 1-22 LID - 10.1080/10640266.2026.2741121 [doi] AB - OBJECTIVE: Many children with avoidant/restrictive food intake disorder (ARFID) cannot access appropriate care, as existing individual and family treatments are scarce, long and costly. We developed a brief 2-day (12-h) multidisciplinary parent training group and assessed its feasibility and acceptability in routine care. METHOD: Single-arm implementation study in one tertiary centre. Parents of 18 children (5-14 years) with DSM-5 ARFID (17/18 sensory-based; non-French-speaking families excluded) attended two days three weeks apart. Guided by the RE-AIM framework, we assessed reach, feasibility (a priori benchmark >/=75% completion) and acceptability (HAQ-11S; CSQ-8; parents' written feedback). Clinician-rated severity (CGI-S) was an exploratory, uncontrolled signal. RESULTS: Of 26 eligible families, 18 (69%) enrolled and 16 (89%) completed both days, exceeding the benchmark; attendance was almost exclusively maternal (83%). HAQ-11S and CSQ-8 scores were high and increased post-program (p < .001), and all respondents rated the satisfaction questionnaire positively. Parents' immediate self-reports most often cited better understanding of the disorder, increased competence and reduced isolation. CGI-S was numerically lower afterwards but this uncontrolled change cannot be attributed to the intervention. CONCLUSION: This brief multidisciplinary parent group for paediatric ARFID is feasible and highly acceptable in this specialist setting, resource use and clinical benefit require controlled evaluation. FAU - Carletti, Leila AU - Carletti L AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Porte, Chloe AU - Porte C AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Helbert, Sarah AU - Helbert S AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Hooreman, Marie AU - Hooreman M AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Charpentier, Firiel AU - Charpentier F AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. AD - Department of Medicine, Paris Cite University, Paris, France. FAU - Delorme, Richard AU - Delorme R AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. AD - Department of Medicine, Paris Cite University, Paris, France. FAU - Stordeur, Coline AU - Stordeur C AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Villemonteix, Thomas AU - Villemonteix T AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. AD - Department of Psychology, DysCo Lab, Paris 8 University, Paris, France. AD - Department of Psychology, Institut Universitaire de France, Paris, France. FAU - Ayrolles, Anael AU - Ayrolles A AUID- ORCID: 0000-0002-3202-0781 AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. AD - Department of Medicine, Paris Cite University, Paris, France. LA - eng PT - Journal Article DEP - 20261008 PL - United States TA - Eat Disord JT - Eating disorders JID - 9315161 SB - IM EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:31 CRDT- 2026/10/08 03:13 PHST- 2026/10/08 05:31 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 03:13 [entrez] AID - 10.1080/10640266.2026.2741121 [doi] PST - aheadofprint SO - Eat Disord. 2026 Oct 8:1-22. doi: 10.1080/10640266.2026.2741121. PMID- 42844973 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261016 IS - 1399-3038 (Electronic) IS - 0905-6157 (Print) IS - 0905-6157 (Linking) VI - 37 IP - 10 DP - 2026 Oct TI - Feeding characteristics in young children with IgE-mediated food allergies: A cross-sectional observational study. PG - e70508 LID - 10.1111/pai.70508 [doi] LID - e70508 AB - BACKGROUND: Research is limited regarding the intersection between Immunoglobulin-E (IgE)-mediated food allergies and paediatric feeding Disorder (PFD). The impact on caregivers managing a child with both conditions also remains poorly understood. OBJECTIVE: This study aimed to explore feeding characteristics in young children with IgE-mediated food allergies to identify the proportion of children who may be at risk of PFD, and to examine associations between risk of PFD and caregiver-reported stress and feeding-related quality of life. METHODS: A cross-sectional cohort (N = 107) of caregivers of children aged 0;6-4;11 years, with at least one diagnosed IgE-mediated food allergy, was recruited from three paediatric allergy clinics. Validated caregiver-reported questionnaires were used to assess feeding behaviours, caregiver stress and feeding-related quality of life. RESULTS: Seventeen (16%) children were identified as being at risk of PFD based on the Behavioural Pediatric Feeding Assessment Scale-Total Frequency Score (BPFAS-TFS). Across the cohort, caregiver stress fell within the expected range. However, caregivers of children at risk of PFD reported significantly higher levels of stress on the Parental Stress Scale (PSS) (p < .001) and poorer feeding-related quality of life on the Feeding Swallowing-Impact Scale (FS-IS) (p < .001). CONCLUSION: Sixteen percent of children with IgE-mediated food allergies screened as being at risk of PFD, suggesting that screening and assessment of PFD are valuable in this population. More frequent difficult mealtime behaviours were associated with increased caregiver stress and lower feeding-related quality of life. Health services must recognise the compounded stressors of managing both food allergies and feeding behaviours/PFD to deliver holistic, family-centred care. CI - (c) 2026 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Kefford, Jennifer AU - Kefford J AUID- ORCID: 0000-0002-0465-6029 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Northern Sydney Local Health District, New South Wales Health, Sydney, New South Wales, Australia. FAU - Ward, Elizabeth C AU - Ward EC AUID- ORCID: 0000-0002-2680-8978 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Centre for Functioning and Health Research (CFAHR), Metro South Hospital and Health Service, Brisbane, Queensland, Australia. FAU - Packer, Rebecca L AU - Packer RL AUID- ORCID: 0000-0002-5744-7757 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. FAU - Netting, Merryn AU - Netting M AUID- ORCID: 0000-0002-0642-9145 AD - National Allergy Council, Sydney, New South Wales, Australia. AD - Department of Paediatrics, University of Adelaide, Adelaide, South Australia, Australia. FAU - Swamy, Shruti AU - Swamy S AUID- ORCID: 0009-0008-2396-3260 AD - The University of Sydney, Sydney, New South Wales, Australia. AD - Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. AD - Royal North Shore Hospital, Sydney, New South Wales, Australia. AD - Sydney Children's Hospital Randwick, Sydney, New South Wales, Australia. FAU - Ford, Lara S AU - Ford LS AD - The University of Sydney, Sydney, New South Wales, Australia. AD - The Children's Hospital at Westmead, Sydney, New South Wales, Australia. FAU - Marshall, Jeanne AU - Marshall J AUID- ORCID: 0000-0003-0652-9258 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia. LA - eng GR - Speech Pathology Australia/ PT - Journal Article PT - Observational Study PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Food Hypersensitivity/epidemiology/immunology MH - Female MH - Male MH - Child, Preschool MH - Infant MH - *Feeding Behavior MH - Immunoglobulin E/immunology/blood MH - Quality of Life MH - Caregivers/psychology MH - Stress, Psychological/epidemiology MH - Surveys and Questionnaires MH - Child MH - *Feeding and Eating Disorders of Childhood/epidemiology PMC - PMC13646849 OTO - NOTNLM OT - caregiver burden OT - feeding and eating disorders OT - feeding behaviours OT - food allergy OT - food hypersensitivity COIS- None. EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:32 PMCR- 2026/10/08 CRDT- 2026/10/08 02:54 PHST- 2026/09/15 00:00 [revised] PHST- 2026/03/07 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/08 05:32 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 02:54 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - PAI70508 [pii] AID - 10.1111/pai.70508 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 Oct;37(10):e70508. doi: 10.1111/pai.70508. PMID- 42843881 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261010 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 10 DP - 2026 Oct 7 TI - Does nicotinamide riboside supplementation increase milk production in postpartum women with infants admitted to a neonatal intensive care unit? Protocol for the MOONRISE randomised, double-blind, placebo-controlled pilot feasibility trial. PG - e118516 LID - 10.1136/bmjopen-2026-118516 [doi] LID - e118516 AB - INTRODUCTION: An adequate supply of a mother's own milk plays a critical role in optimising health outcomes for at-risk hospitalised infants. Insufficient milk production disproportionately affects the mothers of these infants. In the USA, metoclopramide is the only approved drug available for off-label use as a galactagogue. Nicotinamide riboside (NR), a direct precursor to nicotinamide adenine dinucleotide (NAD(+)), has been shown in a murine model to augment high-quality milk production and enhance cognitive and physical development of pups. Human testing with NR has been limited, and studies in lactating individuals have not been performed. The aim of this study is to assess the feasibility of NR supplementation in mothers whose infants are admitted to the neonatal intensive care unit (NICU) for at least 4 weeks. METHOD AND ANALYSIS: This double-blind, randomised, placebo-controlled pilot feasibility trial aims to investigate NR supplementation in mothers of infants who are anticipated to be hospitalised in the NICU for at least 4 weeks. We plan to enroll 40 mother-infant pairs with the expectation that 30 will complete the study (n=15 in each group). The intervention period with maternal NR supplementation or placebo supplementation and maternal milk, urine and blood sampling will be 19 days, including an enrollment day.The primary endpoint of the study includes feasibility of enrolling >/=50% of eligible mothers. Secondary endpoints include compliance, adherence or withdrawal from the protocol. Similarly, the study will assess the difference in mean milk volume, macronutrient and micronutrient content, human milk glycans, milk and urine metabolites and infant feeding practice between the two groups. Optional secondary endpoints include differences in serum prolactin, liver function, plasma lipidome, serum metabolites, serum cellular communication network factor 3 concentrations, serum NAD(+)-related precursors and intermediates between mothers of the two groups. Exploratory outcomes include changes in mothers' weight and infants' developmental and NICU outcomes. Safety endpoints include the frequency of adverse events. ETHICS AND DISSEMINATION: The Institutional Review Board (IRB) protocol version date is 1 June 2026, approved by the IRB at the University of California Davis Medical Center (approval number: 1557473). Study investigators will communicate trial results to participants, healthcare professionals and the public through peer-reviewed publications and presentations at scientific conferences. Trial results will also be reported on ClinicalTrials.gov and made available through PubMed Central, in accordance with regulatory requirements. Deidentified participant data will be available to qualified researchers upon request after publication. Approved requests will be granted access within 12 months and are subject to study team and IRB approval and a data use agreement. TRIAL REGISTRATION NUMBER: NCT04614714. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Khanal, Luna AU - Khanal L AUID- ORCID: 0009-0002-0074-5101 AD - Department of Pediatrics, University of California Davis Health, Sacramento, California, USA. FAU - Cernioglo, Karina AU - Cernioglo K AD - Department of Family Medicine, Kaiser Permanente, Sacramento, California, USA. FAU - Smilowitz, Jennifer T AU - Smilowitz JT AUID- ORCID: 0000-0003-1165-1944 AD - Department of Nutrition, University of California Davis, Davis, California, USA. FAU - German, J Bruce AU - German JB AD - Department of Food Science and Technology, University of California Davis, Davis, California, USA. AD - Foods for Health Institute, University of California Davis, Davis, California, USA. FAU - Underwood, Mark A AU - Underwood MA AD - Department of Pediatrics, University of California Davis Health, Sacramento, California, USA. FAU - Kuhn-Riordon, Kara AU - Kuhn-Riordon K AUID- ORCID: 0000-0001-7346-6299 AD - Department of Pediatrics, University of California Davis Health, Sacramento, California, USA. FAU - Cacho, Nicole T AU - Cacho NT AUID- ORCID: 0000-0002-3269-9122 AD - Department of Pediatrics, University of California Davis, Davis, California, USA ntcacho@ucdavis.edu. LA - eng SI - ClinicalTrials.gov/NCT04614714 PT - Clinical Trial Protocol PT - Journal Article DEP - 20261007 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 25X51I8RD4 (Niacinamide) RN - 0I8H2M0L7N (nicotinamide-beta-riboside) RN - 0 (Pyridinium Compounds) SB - IM MH - Humans MH - Female MH - Double-Blind Method MH - Pilot Projects MH - *Niacinamide/analogs & derivatives/administration & dosage MH - Feasibility Studies MH - Infant, Newborn MH - *Dietary Supplements MH - Intensive Care Units, Neonatal MH - *Lactation/drug effects MH - *Milk, Human/drug effects MH - Randomized Controlled Trials as Topic MH - Postpartum Period MH - *Pyridinium Compounds/administration & dosage MH - Breast Feeding MH - Adult PMC - PMC13646992 OTO - NOTNLM OT - Neonatal intensive & critical care OT - Nutrition OT - Postpartum Women COIS- Competing interests: None declared. EDAT- 2026/10/07 23:30 MHDA- 2026/10/07 23:31 PMCR- 2026/10/07 CRDT- 2026/10/07 20:35 PHST- 2026/10/07 23:31 [medline] PHST- 2026/10/07 23:30 [pubmed] PHST- 2026/10/07 20:35 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - bmjopen-2026-118516 [pii] AID - 10.1136/bmjopen-2026-118516 [doi] PST - epublish SO - BMJ Open. 2026 Oct 7;16(10):e118516. doi: 10.1136/bmjopen-2026-118516. PMID- 42843868 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261010 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 10 DP - 2026 Oct 7 TI - Developing a youth sustainability healthy active living intervention for chronic disease prevention and environmental sustainability through community engagement and codesign: protocol for a multimethod community-based participatory research study in Canada and Jamaica. PG - e119261 LID - 10.1136/bmjopen-2026-119261 [doi] LID - e119261 AB - BACKGROUND: Most non-communicable diseases (NCDs) develop through multiple complex pathways that involve non-modifiable and modifiable risk factors. Prevention efforts optimally involve a life course approach that promotes healthy eating and physical activity because behaviours adopted early in adolescence and young adulthood are likely to be sustained and can prevent NCDs in later life. This research protocol describes a community-based co-designed study taking place in Canada and Jamaica that positions youth aged 15-25 as agents-of-change in their communities to increase knowledge and develop tools to adopt and promote sustainable practices and healthy active living. METHODS: The SCORE! Youth Sustainability Healthy Active Living (SCORE! Youth-SHAL)-Community Engagement and Co-design is a multimethod community-based participatory research (CBPR) study to be conducted in two sequential stages. Stage 1 involves community contextual mapping, a maximum of two community engagement workshops along with key informant interviews with both youth and stakeholders. Stage 2 includes a co-design workshop with local youth to develop customised healthy active living activities. Participants will be recruited using convenience and purposive sampling. Workshops and interviews will be audio-recorded and transcribed. Data will be collected to understand the SHAL intervention's feasibility, fidelity and contextual fit across diverse settings. Content and thematic analysis will occur concurrently and iteratively with data collection. ETHICS AND DISSEMINATION: This study has approval from Hamilton Integrated Research Ethics Board in Health Sciences, Brock University Research Ethics Board, The University of the West Indies-Mona Campus Research Ethics Committee, and Ministry of Health and Wellness, Jamaica-Advisory Panel on Ethics and Medico-Legal Affairs. Findings assist in finalising a SHAL intervention for youth in equity-deserving populations. We will also publish the study results in an academic journal and present at conferences, webinars and workshops. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Stennett, Rosain AU - Stennett R AUID- ORCID: 0000-0003-3386-2558 AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - Kandasamy, Sujane AU - Kandasamy S AUID- ORCID: 0000-0003-4326-2783 AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - The Starfish Environmental Society, Hamilton, Ontario, Canada. FAU - Sherifali, Diana AU - Sherifali D AD - School of Nursing, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - de Souza, Russell J AU - de Souza RJ AUID- ORCID: 0000-0001-8945-513X AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Department of Health Research Methods, Evidence, and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - Desai, Dipika AU - Desai D AD - Department of Health Research Methods, Evidence, and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Population Health Research Institute/Hamilton Health Sciences, Hamilton, Ontario, Canada. FAU - Kwan, Matthew Yw AU - Kwan MY AD - Department of Child and Youth Studies, Brock University, St Catharines, Ontario, Canada. AD - Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. FAU - Smith, Joanne A AU - Smith JA AD - Epidemiology Research Unit, Caribbean Institute for Health Research, The University of the West Indies, Mona, Kingston 7, Jamaica. FAU - Edwards, Thera AU - Edwards T AD - Department of Geography and Geology, The University of the West Indies, Mona, Kingston 7, Jamaica. AD - Tropical Metabolism Research Unit, Caribbean Institute for Health Research, The University of the West Indies, Mona, Kingston 7, Jamaica. FAU - Gordon-Strachan, Georgiana AU - Gordon-Strachan G AD - Tropical Metabolism Research Unit, Caribbean Institute for Health Research, The University of the West Indies, Mona, Kingston 7, Jamaica. FAU - Bangdiwala, Shrikant I AU - Bangdiwala SI AD - Department of Health Research Methods, Evidence, and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Population Health Research Institute/Hamilton Health Sciences, Hamilton, Ontario, Canada. FAU - Wahi, Gita AU - Wahi G AUID- ORCID: 0000-0001-5943-9702 AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - Brook, Jeffrey AU - Brook J AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. FAU - Sergeant, Myles AU - Sergeant M AD - Family Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Canadian Coalition for Green Health Care, Hamilton, Ontario, Canada. FAU - Krishanthan, Alisha AU - Krishanthan A AD - Health Sciences Program, Western University, London, Ontario, Canada. FAU - Desai, Sneha AU - Desai S AD - Arts & Science Program, McMaster University, Hamilton, Ontario, Canada. FAU - Anderson, Simon G AU - Anderson SG AD - George Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, The University of the West Indies, Bridgetown, Barbados. AD - Glasgow-Caribbean Centre for Development Research, The University of the West Indies, Mona, Kingston 7, Jamaica. FAU - Anand, Sonia S AU - Anand SS AUID- ORCID: 0000-0003-3692-7441 AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada anands@mcmaster.ca. AD - Population Health Research Institute/Hamilton Health Sciences, Hamilton, Ontario, Canada. LA - eng PT - Journal Article DEP - 20261007 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Community-Based Participatory Research MH - Jamaica MH - Canada MH - Adolescent MH - *Health Promotion/methods MH - Young Adult MH - Research Design MH - Chronic Disease/prevention & control MH - *Exercise MH - Female MH - *Community Participation PMC - PMC13646957 OTO - NOTNLM OT - Community Participation OT - Community-Based Participatory Research OT - QUALITATIVE RESEARCH OT - Young Adult COIS- Competing interests: RJdS has served as an external resource person to the World Health Organization's Nutrition Guidelines Advisory Group on trans fats, saturated fats, and polyunsaturated fats. The WHO paid for his travel and accommodation to attend meetings from 2012-2017 to present and discuss this work. He has also done contract research for the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism, and Diabetes, Health Canada, and the World Health Organization, for which he received remuneration. He has received speaker's fees from the University of Toronto and McMaster Children's Hospital. He has held grants from the Canadian Institutes of Health Research, Canadian Foundation for Dietetic Research, Population Health Research Institute, and Hamilton Health Sciences Corporation as a principal investigator, and is a co-investigator on several funded team grants from the Canadian Institutes of Health Research. He serves as a member of the Nutrition Science Advisory Committee to Health Canada (Government of Canada), a co-opted member of the Scientific Advisory Committee on Nutrition (SACN) Subgroup on the Framework for the Evaluation of Evidence (Public Health England), and as an independent director of the Helderleigh Foundation (Canada). SSA is an Associate Vice-President of Global Health, McMaster University and a Senior Scientist at the Population Health Research Institute. She currently serves on the Editorial Board of The British Medical Journal and is an Associate Editor of JAMA Cardiology. SSA has received grants from the Public Health Agency of Canada, Heart & Stroke, Canadian Institutes of Health Research. She has served as a Consultant and received payment/honoraria for lectures, presentations and speaker bureaus from Bayer AG, Janssen Pharmaceuticals, Novartis Pharmaceuticals Canada, Novo Nordisk Amgen, HSL Therapeutics, Daiichi Sankyo, Regeneron and Eli Lily. She has held a Tier 1 Canada Research Chair in Ethnicity and CVD (#CRC-2017-00024) for two successive terms, Heart & Stroke Foundation Chair in Population Health and Michael G. DeGroote Chair in Population Health Research. EDAT- 2026/10/07 23:30 MHDA- 2026/10/07 23:31 PMCR- 2026/10/07 CRDT- 2026/10/07 20:35 PHST- 2026/10/07 23:31 [medline] PHST- 2026/10/07 23:30 [pubmed] PHST- 2026/10/07 20:35 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - bmjopen-2026-119261 [pii] AID - 10.1136/bmjopen-2026-119261 [doi] PST - epublish SO - BMJ Open. 2026 Oct 7;16(10):e119261. doi: 10.1136/bmjopen-2026-119261. PMID- 42843149 OWN - NLM STAT- Publisher LR - 20261022 IS - 1878-9307 (Electronic) IS - 1878-9293 (Print) IS - 1878-9293 (Linking) VI - 82 DP - 2026 Sep 21 TI - A systematic review of digital and wearable sensor data in the ABCD study: Insights, methods, and emerging opportunities. PG - 101826 LID - S1878-9293(26)00168-4 [pii] LID - 10.1016/j.dcn.2026.101826 [doi] LID - 101826 AB - Research into key adolescent health domains, like problematic screen-based media use, sleep health, and physical activity, are frequently limited by error-prone self-report-based measures. To improve the measurement of such behaviors, the Adolescent Brain Cognitive Development Study (ABCD), a diverse longitudinal cohort study of nearly 12,000 U.S. youth (ages 9-10 at Baseline), includes remote sensing protocols during data collection. Consenting participants provided up to three weeks of Fitbit actigraphy data, beginning at the year-two follow up, and smartphone usage data, beginning at the year-four follow up, collected via the Effortless Assessment of Research Systems (EARS) smartphone application. This systematic review aimed to identify and synthesize all published empirical studies which have utilized the ABCD Study's passive sensor data, identifying 45 articles investigating measurement validity, and associations with adolescent health, development, and neurocognitive functioning. Fitbit devices broadly reproduced estimates of sleep and physical activity obtained from research-grade sensors. Smartphone sensor data were internally consistent, reproduced expected daily usage patterns, and were moderately correlated with self-report. Most substantive studies utilized Fitbit data and reported cross-sectional associations between sensor-derived single-item summary statistics and survey-based measures of mental and behavioral health, neurocognitive functioning, or environmental risk factors. A smaller number of studies utilized longitudinal designs, within-person analyses, machine learning approaches, and/or genetic or neuroimaging methods to reduce confounding and enhance biological and etiological insight into these observed relationships. While published findings were largely incremental in nature, ABCD's passive sensing resources nonetheless represent a powerful, widely available resource for incorporating sensor-based measures into adolescent health research. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Alexander, Jordan D AU - Alexander JD AD - Psychology Department, University of Maine, Orono, ME, United States. Electronic address: jordan.d.alexander@maine.edu. FAU - Mills, Sawyer AU - Mills S AD - Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, United States. FAU - Sumpter, Kelsey AU - Sumpter K AD - School of Medicine, University of Maryland at Baltimore, Baltimore, MD, United States. FAU - Smith, Calen J AU - Smith CJ AD - J. Craig Venter Institute, La Jolla, CA, United States. FAU - Das, Biplabendu AU - Das B AD - J. Craig Venter Institute, La Jolla, CA, United States. FAU - Fan, Ruby AU - Fan R AD - Center for Health Sciences, SRI International, Menlo Park, CA, United States. FAU - Hunt, Ethan T AU - Hunt ET AD - University of Texas Health Science Center at Houston (UTHealth) School of Public Health - Austin Campus, Austin, TX, United States. FAU - Brown, Sandra A AU - Brown SA AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. FAU - Curtis, Brenda L AU - Curtis BL AD - National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, United States. FAU - Cummins, Kevin M AU - Cummins KM AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. FAU - Mason, Michael AU - Mason M AD - Center for Behavioral Health Research, University of Tennessee Knoxville, Knoxville, TN, United States. FAU - Neale, Michael C AU - Neale MC AD - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States. FAU - Tapert, Susan F AU - Tapert SF AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. FAU - Baker, Fiona C AU - Baker FC AD - Center for Health Sciences, SRI International, Menlo Park, CA, United States. FAU - Fuemmeler, Bernard F AU - Fuemmeler BF AD - Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United States. FAU - Wade, Natasha E AU - Wade NE AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. LA - eng GR - U24 DA041147/DA/NIDA NIH HHS/United States GR - U01 DA051039/DA/NIDA NIH HHS/United States GR - U01 DA041120/DA/NIDA NIH HHS/United States GR - K08 DA050779/DA/NIDA NIH HHS/United States GR - U01 DA051018/DA/NIDA NIH HHS/United States GR - U01 DA041093/DA/NIDA NIH HHS/United States GR - U24 DA041123/DA/NIDA NIH HHS/United States GR - U01 DA051038/DA/NIDA NIH HHS/United States GR - U01 DA051037/DA/NIDA NIH HHS/United States GR - U01 DA051016/DA/NIDA NIH HHS/United States GR - U01 DA041106/DA/NIDA NIH HHS/United States GR - U01 DA041117/DA/NIDA NIH HHS/United States GR - T32 DA050560/DA/NIDA NIH HHS/United States GR - U01 DA041174/DA/NIDA NIH HHS/United States GR - U01 DA041134/DA/NIDA NIH HHS/United States GR - U01 DA041022/DA/NIDA NIH HHS/United States GR - U01 DA041156/DA/NIDA NIH HHS/United States GR - U01 DA050987/DA/NIDA NIH HHS/United States GR - U01 DA041025/DA/NIDA NIH HHS/United States GR - U01 DA050989/DA/NIDA NIH HHS/United States GR - U01 DA041089/DA/NIDA NIH HHS/United States GR - U01 DA050988/DA/NIDA NIH HHS/United States GR - U01 DA041028/DA/NIDA NIH HHS/United States GR - U01 DA041048/DA/NIDA NIH HHS/United States GR - ZIA DA000628/ImNIH/Intramural NIH HHS/United States GR - U01 DA041148/DA/NIDA NIH HHS/United States PT - Journal Article DEP - 20260921 PL - Netherlands TA - Dev Cogn Neurosci JT - Developmental cognitive neuroscience JID - 101541838 SB - IM PMC - PMC13676921 OTO - NOTNLM OT - Adolescent development OT - Fitbit OT - Passive Sensing OT - Physical Activity OT - Sensor based data OT - Sleep OT - Smartphone Use COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/07 23:30 MHDA- 2026/10/07 23:30 PMCR- 2026/09/21 CRDT- 2026/10/07 18:09 PHST- 2025/12/01 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/07 23:30 [medline] PHST- 2026/10/07 23:30 [pubmed] PHST- 2026/10/07 18:09 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - S1878-9293(26)00168-4 [pii] AID - 101826 [pii] AID - 10.1016/j.dcn.2026.101826 [doi] PST - aheadofprint SO - Dev Cogn Neurosci. 2026 Sep 21;82:101826. doi: 10.1016/j.dcn.2026.101826. PMID- 42843092 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 1361-8423 (Electronic) IS - 1361-8415 (Linking) VI - 115 DP - 2027 Jan TI - CeLDA+: Prototypical learning for age-robust cephalometric landmark detection. PG - 104330 LID - S1361-8415(26)00399-3 [pii] LID - 10.1016/j.media.2026.104330 [doi] AB - Accurate cephalometric landmark detection is essential for orthodontic diagnosis. However, existing methods predominantly focus on adults and overlook adolescents, whose developmental variations, such as unerupted teeth and mixed dentition, introduce substantial appearance changes and degrade detection performance. These differences motivate a unified framework that performs reliably for adolescent and adult cases. To address this challenge, we propose CeLDA+ (Cephalometric Landmark Detection across Ages), a prototypical learning framework for landmark detection in adolescent and adult populations. Rather than relying on highly variable local appearances, it formulates landmark detection as semantic matching in a high-dimensional feature space. By mapping morphologically diverse instances to compact regions around shared landmark prototypes, the model promotes consistent localization for adolescent and adult cases without requiring age-specific designs. We further introduce two modules: Prototype Geometry Regularization, which enforces geometric consistency among landmarks, and Prototype Relation Mining, which captures semantic dependencies between anatomically related structures. For comprehensive evaluation, we construct two large-scale, multi-center datasets annotated with 46 and 201 landmarks, comprising 2950 samples in total and representing the largest cephalometric benchmarks to date. CeLDA+ consistently outperforms prior state-of-the-art methods across all three benchmarks. On the two mixed-age benchmarks, it achieves the best detection accuracy on both adolescent and adult subsets under joint training, while maintaining the lowest computational cost. CeLDA+ also performs well in two downstream clinical evaluations: skeletal classification, following prior benchmark practice, and cephalometric tracing analysis, newly introduced in this work to provide contour-level evaluation for cephalometric landmark detection. These findings further highlight its applicability in real-world orthodontic scenarios. Our source code and benchmark datasets are available at GitHub. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Wu, Han AU - Wu H AD - School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China. FAU - Jia, Wei AU - Jia W AD - School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China. FAU - Mei, Lanzhuju AU - Mei L AD - School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China. FAU - Yang, Tong AU - Yang T AD - Shanghai Linkedcare Information Technology Co., Ltd., Shanghai, China. FAU - Zhu, Min AU - Zhu M AD - Shanghai Ninth People Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Li, Haizhen AU - Li H AD - Shanghai Ninth People Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: lihaizhen_dent@163.com. FAU - Wang, Chong AU - Wang C AD - Center for Artificial Intelligence in Medicine and Imaging, Stanford University, Palo Alto, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA. Electronic address: chongwa@stanford.edu. FAU - Shen, Dinggang AU - Shen D AD - School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China; Shanghai United Imaging Intelligence Co. Ltd., Shanghai, China; Shanghai Clinical Research and Trial Center, Shanghai, China. FAU - Cui, Zhiming AU - Cui Z AD - School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China. Electronic address: cuizhm@shanghaitech.edu.cn. LA - eng PT - Journal Article DEP - 20260923 PL - Netherlands TA - Med Image Anal JT - Medical image analysis JID - 9713490 SB - IM MH - Humans MH - *Cephalometry/methods MH - *Anatomic Landmarks/diagnostic imaging MH - Adolescent MH - Adult MH - Algorithms MH - Detection Algorithms MH - *Machine Learning OTO - NOTNLM OT - Geometry regularization OT - Landmark detection OT - Prototypical learning OT - Relation mining COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/07 23:30 MHDA- 2026/10/25 03:35 CRDT- 2026/10/07 18:07 PHST- 2026/05/03 00:00 [received] PHST- 2026/08/26 00:00 [revised] PHST- 2026/09/13 00:00 [accepted] PHST- 2026/10/25 03:35 [medline] PHST- 2026/10/07 23:30 [pubmed] PHST- 2026/10/07 18:07 [entrez] AID - S1361-8415(26)00399-3 [pii] AID - 10.1016/j.media.2026.104330 [doi] PST - ppublish SO - Med Image Anal. 2027 Jan;115:104330. doi: 10.1016/j.media.2026.104330. Epub 2026 Sep 23. PMID- 42842838 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 2292-9495 (Electronic) IS - 2292-9495 (Linking) VI - 13 DP - 2026 Oct 7 TI - Development and User Testing of an Online Platform to Deliver School-Based Inclusive Physical Education Solutions: Mixed Methods Study. PG - e89476 LID - 10.2196/89476 [doi] LID - e89476 AB - BACKGROUND: Inclusive physical education (PE) plays a vital role in promoting participation and development among students with different abilities. However, many teachers do not have adequate tools to modify PE activities to meet these diverse needs. In addition, parents are essential partners, as their involvement helps reinforce strategies and provide useful information about their children. While online platforms provide a practical way to deliver such solutions, only a few have been intentionally created to support both teachers and parents in implementing inclusive PE learning. To address this gap, we codeveloped an online platform with adapted PE experts that digitizes an inclusion screening tool and delivers personalized, evidence-based inclusion strategies and resources to teachers and parents. OBJECTIVE: This study aimed to develop an online platform that provides inclusion strategies for PE teachers and to examine how teachers and parents perceived its usability, acceptability, and overall usefulness using a mixed methods approach. METHODS: A mixed methods design was used to evaluate the platform between September 2024 and March 2025. PE teachers (n=8) and parents of children with disabilities (n=8) were recruited through convenience sampling via national social media outreach and completed individual usability testing sessions via Zoom. Usability was assessed using the System Usability Scale (SUS), the Questionnaire for User Interaction Satisfaction (QUIS), and task performance metrics. Semistructured interviews were conducted to explore user experiences. Quantitative data were analyzed descriptively, while qualitative data were analyzed using codebook thematic analysis, with findings integrated using joint display analysis. RESULTS: All participants successfully completed the assigned tasks, with a few instances of minor difficulty (14 total errors across 136 task attempts). Participants completed both usability testing and semistructured interviews. Usability and satisfaction scores were high across both groups (SUS: mean 85.63, SD 9.14 for teachers and mean 84.69, SD 12.50 for parents; QUIS: mean 8.52, SD 0.82 for teachers and mean 8.00, SD 1.31 for parents, out of 9). Mixed methods integration showed convergence between positive usability ratings and perceived professional value, while also identifying challenges related to navigation, terminology, learning for first-time users, and mobile interface design. CONCLUSIONS: The online platform provides strong usability and high satisfaction among PE teachers and parents. Future work will involve improving implementation and evaluating its impact on students' participation outcomes. CI - (c) Sangeetha Mohanraj, Laurie A Malone, Sunkanmi Arogbokun, Lauren Lieberman, Mohanraj Thirumalai. Originally published in JMIR Human Factors (https://humanfactors.jmir.org). FAU - Mohanraj, Sangeetha AU - Mohanraj S AUID- ORCID: 0000-0002-8567-9571 AD - SHP Research Collaborative, School of Health Professions, University of Alabama at Birmingham, 701 20th Street South, Birmingham, AL, 35294, United States. FAU - Malone, Laurie A AU - Malone LA AUID- ORCID: 0000-0001-9426-6325 AD - Department of Occupational Therapy, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - Arogbokun, Sunkanmi AU - Arogbokun S AUID- ORCID: 0009-0008-1571-7916 AD - Rehabilitation Science, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - Lieberman, Lauren AU - Lieberman L AUID- ORCID: 0000-0002-5393-104X AD - Department of Kinesiology, Sport Studies and Physical Education, SUNY Brockport, Brockport, NY, United States. FAU - Thirumalai, Mohanraj AU - Thirumalai M AUID- ORCID: 0000-0001-9768-3829 AD - Division of General Internal Medicine and Population Sciences, Heersink School of Medicine, University of Alabama at Birmingham, 701 19th Street South, ALGEN 580, Birmingham, AL, 35294, United States, +1 2059342206. LA - eng GR - 90REGE0019/ACL/ACL HHS/United States PT - Journal Article DEP - 20261007 PL - Canada TA - JMIR Hum Factors JT - JMIR human factors JID - 101666561 SB - IM MH - Humans MH - *Physical Education and Training/methods MH - Female MH - Male MH - Child MH - Adult MH - Parents MH - *School Teachers MH - Schools MH - Internet MH - Digital Media PMC - PMC13645197 OTO - NOTNLM OT - adapted physical activity OT - inclusive physical education OT - mixed methods OT - professional development OT - students with disabilities OT - teacher training OT - usability OT - user testing COIS- Conflicts of Interest: None declared. EDAT- 2026/10/07 17:33 MHDA- 2026/10/07 17:34 PMCR- 2026/10/07 CRDT- 2026/10/07 15:53 PHST- 2025/12/12 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/07 17:34 [medline] PHST- 2026/10/07 17:33 [pubmed] PHST- 2026/10/07 15:53 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - v13i1e89476 [pii] AID - 89476 [pii] AID - 10.2196/89476 [doi] PST - epublish SO - JMIR Hum Factors. 2026 Oct 7;13:e89476. doi: 10.2196/89476. PMID- 42842533 OWN - NLM STAT- Publisher LR - 20261020 IS - 1423-0097 (Electronic) IS - 1018-2438 (Linking) DP - 2026 Oct 7 TI - Clinical and Immunological Determinants of Time to Open Oral Food Challenge-Confirmed Tolerance in Children with IgE-Mediated Food Allergy: A Retrospective Cohort Study. PG - 1 LID - 10.1159/iaa/adfag028 [doi] AB - INTRODUCTION: The timing of tolerance acquisition in childhood IgE-mediated food allergy is clinically important but has been less well studied than persistence as a binary outcome. We examined clinical and immunological determinants of time to open oral food challenge (OFC)-confirmed tolerance. METHODS: This retrospective cohort study included 157 children with physician-established IgE-mediated food allergy evaluated at a tertiary pediatric allergy clinic between January 2023 and July 2026. Time zero was defined as elimination-diet initiation; tolerance was defined exclusively by a successful supervised open OFC. One mutually exclusive index allergen was assigned to each child and used consistently to define the time-to-tolerance outcome. Kaplan-Meier analysis and parametric accelerated failure time (AFT) models were used. The log-logistic model, adjusted for index allergen and the prespecified clinical and immunological covariates, was selected for multivariable analysis and internally validated using 1,000 bootstrap resamples. RESULTS: Of 157 children, 120 achieved OFC-confirmed tolerance and 37 were right-censored. The mutually exclusive index-allergen distribution was hen's egg (n = 103), cow's milk (n = 35), tree nut (n = 16), other food (n = 2), and fish (n = 1). In the index-allergen-adjusted log-logistic AFT model, food-induced anaphylaxis (adjusted time ratio [TR]: 2.13, 95% CI: 1.34-3.36; p = 0.001), allergic rhinitis (adjusted TR: 1.80, 95% CI: 1.26-2.55; p = 0.001), and each 10-fold increase in total IgE (adjusted TR: 1.54, 95% CI: 1.20-1.98; p < 0.001) were associated with a longer time to tolerance. Tree-nut index allergy was also associated with longer time to tolerance than hen's egg (adjusted TR: 2.74, 95% CI: 1.19-6.29; p = 0.018), although this estimate was based on few tolerance events. CONCLUSION: Previous food-induced anaphylaxis, allergic rhinitis, higher total IgE, and index food type were associated with the timing of open OFC-confirmed tolerance in children with IgE-mediated food allergy. Routine quantitative IgG, IgA, and IgM measures were not independently associated with tolerance timing. CI - (c) The Author(s) 2026. Published by S. Karger AG. FAU - Kangalli Boyacioglu, Ozge AU - Kangalli Boyacioglu O FAU - Soyoz, Ozgen AU - Soyoz O FAU - Erdem Bahceci, Semiha AU - Erdem Bahceci S LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Int Arch Allergy Immunol JT - International archives of allergy and immunology JID - 9211652 SB - IM OTO - NOTNLM OT - Anaphylaxis OT - Food tolerance OT - IgE-mediated food allergy OT - Oral food challenge OT - Survival analysis OT - Total IgE EDAT- 2026/10/07 17:33 MHDA- 2026/10/07 17:33 CRDT- 2026/10/07 13:28 PHST- 2026/08/04 00:00 [received] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/07 17:33 [pubmed] PHST- 2026/10/07 17:33 [medline] PHST- 2026/10/07 13:28 [entrez] AID - 000554585 [pii] AID - 10.1159/iaa/adfag028 [doi] PST - aheadofprint SO - Int Arch Allergy Immunol. 2026 Oct 7:1. doi: 10.1159/iaa/adfag028. PMID- 42840287 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261007 LR - 20261008 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Implementation of a non-separation pathway for late preterm infants in a tertiary care center: a prospective feasibility study. PG - 1919628 LID - 10.3389/fped.2026.1919628 [doi] LID - 1919628 AB - BACKGROUND: Late preterm infants (34 + 0-36 + 6 weeks' gestation) are at increased risk of feeding difficulties, hypoglycemia, hypothermia, and early mother-infant separation. Although skin-to-skin contact and rooming-in are recommended components of family-centered neonatal care, evidence regarding the implementation of integrated non-separation strategies in late preterm infants remains limited. This study evaluated the implementation, feasibility, safety, and early clinical outcomes of a Non-Separation Pathway in a tertiary care setting. METHODS: We conducted a prospective observational cohort study after implementation of a Non-Separation Pathway at a Belgian tertiary university hospital. Mother-infant dyads with infants born between 34 + 0 and 36 + 6 weeks' gestation were enrolled between April 2023 and March 2024. The pathway consists of three interconnected components: (1) immediate and sustained delivery-room SSC, (2) continuous rooming-in, and (3) structured feeding support according to a standardized protocol based on Academy of Breastfeeding Medicine. Primary outcomes were pathway implementation, feasibility, and safety, with complete non-separation as the primary implementation outcome. Secondary outcomes included feeding practices, hypoglycemia, weight loss, length of stay, and feeding status at discharge. RESULTS: Sixty-nine mother-infant dyads were included. Mean gestational age was 35.6 weeks and mean birth weight was 2,502 g. Complete non-separation was achieved in 37.3% of dyads, delivery room skin-to-skin contact in 82.6%. Vaginal birth (aOR 5.12, 95% CI 1.51-17.39) and higher gestational age (aOR 2.14, 95% CI 1.06-4.35) were independently associated with complete non-separation. Respiratory support was independently associated with lower odds of delivery-room skin-to-skin contact (aOR 0.04, 95% CI 0.004-0.41). Hypothermia occurred in 18.8% of infants and was associated with surrogate skin-to-skin contact (aOR 6.67, 95% CI 1.71-26.03). At discharge, 75.4% of infants received any mother's milk and 34.8% were exclusively breastfed. CONCLUSIONS: Implementation of the Non-Separation Pathway demonstrated that delivery-room SSC was feasible for most late preterm infants in a tertiary neonatal setting and was not associated with major safety concerns. However, complete non-separation throughout hospitalization was achieved in only 37% of dyads and remained constrained by respiratory support requirements, cesarean delivery, maternal and neonatal complexity, limited intermediate-care capacity, and the absence of rooming-in facilities in the NICU. CI - (c) 2026 Janssens and Eerdekens. FAU - Janssens, Elien AU - Janssens E AD - Department of Pediatrics and Neonatology, Residency Program, University Hospital Leuven, Leuven, Belgium. FAU - Eerdekens, An AU - Eerdekens A AD - Neonatology Department, University Hospital Leuven -KU Leuven, Leuven, Belgium. LA - eng PT - Journal Article DEP - 20260922 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13638661 OTO - NOTNLM OT - breastfeeding OT - family-centered care OT - late preterm infant OT - neonatal outcomes OT - non-separation OT - rooming-in OT - skin-to-skin contact COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/07 11:32 MHDA- 2026/10/07 11:33 PMCR- 2026/09/22 CRDT- 2026/10/07 07:55 PHST- 2026/06/25 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/10/07 11:33 [medline] PHST- 2026/10/07 11:32 [pubmed] PHST- 2026/10/07 07:55 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - 10.3389/fped.2026.1919628 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 22;14:1919628. doi: 10.3389/fped.2026.1919628. eCollection 2026. PMID- 42840151 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261007 LR - 20261008 IS - 2251-6581 (Print) IS - 2251-6581 (Electronic) IS - 2251-6581 (Linking) VI - 25 IP - 2 DP - 2026 Dec TI - Empirical dietary and lifestyle indices for hyperinsulinemia and insulin resistance in relation to metabolic health in overweight and obese children and adolescents. PG - 282 LID - 10.1007/s40200-026-02096-y [doi] LID - 282 AB - PURPOSE: Empirical dietary and lifestyle indices reflecting hyperinsulinemia and insulin resistance have been associated with adverse metabolic outcomes in adults, but pediatric evidence is limited. We examined associations with metabolic health phenotypes in youth with excess weight. METHODS: In this cross-sectional study, 427 Iranian participants aged 6-18 years with overweight or obesity were classified as metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO) using established cardiometabolic criteria. Dietary intake was assessed with a validated food frequency questionnaire. Modified versions of the empirical dietary and lifestyle indices for hyperinsulinemia (EDIH and ELIH) and insulin resistance (EDIR and ELIR) were calculated using the components available in the Iranian FFQ. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), with subgroup analyses by age and sex. RESULTS: Higher adherence to ELIH and ELIR was significantly associated with increased odds of MUO (OR for Q4 vs. Q1: 3.19 and 2.41, respectively; P-trend < 0.05), while no significant associations were observed for EDIH or EDIR. Exploratory subgroup analyses showed ELIH-MUO associations in participants aged < 10 years and boys, EDIR-MUO associations in girls, and ELIR-MUO associations in girls and, for the Q4-versus-Q1 comparison only, participants aged >/= 10 years (P-trend = 0.09). CONCLUSIONS: Higher lifestyle-based insulinemic scores, particularly ELIH and ELIR, were associated with an unfavorable metabolic phenotype in youth with excess weight. Because these modified indices are empirical biomarker-prediction tools, their component weights should not be interpreted as causal effects of individual foods. Prospective and population-specific validation studies are warranted. TRIAL REGISTRATION: Not applicable. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at https://doi.org/10.1007/s40200-026-02096-y. CI - (c) The Author(s), under exclusive licence to Tehran University of Medical Sciences 2026. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Nikparast, Ali AU - Nikparast A AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 FAU - Nourian, Nazanin Zahra AU - Nourian NZ AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 FAU - Tabatabaeyan, Ali AU - Tabatabaeyan A AD - Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. ROR: https://ror.org/04waqzz56. GRID: grid.411036.1. ISNI: 0000 0001 1498 685X FAU - Razavi, Maryam AU - Razavi M AD - Growth and Development Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Khoshnezhad Afkham, Ehsan AU - Khoshnezhad Afkham E AD - Department of Pediatrics, School of Medicine, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Etesami, Elahe AU - Etesami E AD - Department of Nutrition, SR.C., Islamic Azad University, Tehran, Iran. ROR: https://ror.org/01kzn7k21. GRID: grid.411463.5. ISNI: 0000 0001 0706 2472 FAU - Asghari, Golaleh AU - Asghari G AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 LA - eng PT - Journal Article DEP - 20261005 PL - Switzerland TA - J Diabetes Metab Disord JT - Journal of diabetes and metabolic disorders JID - 101590741 PMC - PMC13638921 OTO - NOTNLM OT - Empirical dietary index OT - Hyperinsulinemia OT - Insulin resistance OT - Metabolic health OT - Pediatric obesity COIS- Competing interestsThe authors declare no competing interests. EDAT- 2026/10/07 11:32 MHDA- 2026/10/07 11:33 PMCR- 2027/10/05 CRDT- 2026/10/07 07:05 PHST- 2025/10/18 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/07 11:33 [medline] PHST- 2026/10/07 11:32 [pubmed] PHST- 2026/10/07 07:05 [entrez] PHST- 2027/10/05 00:00 [pmc-release] AID - 2096 [pii] AID - 10.1007/s40200-026-02096-y [doi] PST - epublish SO - J Diabetes Metab Disord. 2026 Oct 5;25(2):282. doi: 10.1007/s40200-026-02096-y. eCollection 2026 Dec. PMID- 42838807 OWN - NLM STAT- Publisher LR - 20261006 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) DP - 2026 Sep 21 TI - Evaluation of renal functional reserve in primary vesicoureteric reflux: A cross-sectional study. PG - 106293 LID - S1477-5131(26)00572-3 [pii] LID - 10.1016/j.jpurol.2026.106293 [doi] AB - BACKGROUND: The role of renal functional reserve (RFR) in children with vesicoureteric reflux (VUR) is understudied. The objective of this study was to determine RFR [assessed by Diethylenetriaminepentaacetic acid (DTPA) scan] in patients aged 2-18 years with primary VUR. METHODS: This cross-sectional study evaluated RFR in 50 children with primary VUR. Baseline and stimulated (after 1 g/kg protein meal) GFR were measured using technetium-99m (Tc-99m) DTPA plasma clearance (Russell's two-sample method). RFR was calculated as the proportional GFR increase, with >10% defined as positive RFR and compared across grades of VUR and scars. RFR was also assessed by timed urinary creatinine clearance. RESULTS: The median age at RFR estimation was 4.3 [IQR:2.9, 8.1] years, while median age-at-diagnosis was 7 [2, 24] months. The median duration of illness was 3.6 [2.3, 6.2] years. Initial presentations included urinary tract infections (UTI) in 31 (62%) children and antenatal hydronephrosis in 18 (36%), with 90% (n = 45) having a history of prior pyelonephritis. Patients were categorized by VUR severity: unilateral low-grade (n = 7; 14%), unilateral high-grade (n = 14; 28%), bilateral high-grade (n = 26; 52%), and bilateral low-grade (n = 3; 6%). The median DTPA RFR was 13.67 [5.84, 28.27]%, with 60% (n = 30) demonstrating a positive RFR. RFR compared among children with low-grade vs high-grade VUR, demonstrated no statistically significant difference (p = 0.28). DTPA-RFR correlated weakly with timed creatinine clearance RFR (r = 0.20), which consistently overestimated RFR. The median-annual-decline rate was higher in group with absent RFR (-4.2 vs improvement of 18.25 mL/min/1.73 m(2)/year), with a median difference of 22.45 mL/min/1.73 m(2)/year (bootstrap 95% CI 4.58, 60.74), p = 0.011. CONCLUSIONS: In conclusion, preserved RFR was noted in nearly two-thirds of children with VUR, with no significant difference with disease severity. The study demonstrates that RFR can be measured using different methodologies in children with VUR and provides valuable feasibility data. CI - Copyright (c) 2026 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. FAU - Ettiappan, Sukumar AU - Ettiappan S AD - Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: sukumar45.sm@gmail.com. FAU - Deepthi, Bobbity AU - Deepthi B AD - Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: deepu.reddy222@gmail.com. FAU - Ponnusamy, Madhusudhanan AU - Ponnusamy M AD - Department of Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: freethinker_13@yahoo.co.in. FAU - Naredi, Bikash Kumar AU - Naredi BK AD - Department of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: bikashnaredi@gmail.com. FAU - Krishnasamy, Sudarsan AU - Krishnasamy S AD - Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: sudarsanjipmer@gmail.com. FAU - Krishnamurthy, Sriram AU - Krishnamurthy S AD - Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: drsriramk@yahoo.com. LA - eng PT - Journal Article DEP - 20260921 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM OTO - NOTNLM OT - CKD OT - DMSA OT - DTPA OT - Renal functional reserve OT - Renal scar OT - Vesicouretic reflux COIS- Conflict of interest The authors have no competing interests to declare that are relevant to the content of this article. The authors have no financial or proprietary interests in any material discussed in this article. EDAT- 2026/10/06 23:29 MHDA- 2026/10/06 23:29 CRDT- 2026/10/06 22:00 PHST- 2026/04/02 00:00 [received] PHST- 2026/09/02 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/06 23:29 [medline] PHST- 2026/10/06 23:29 [pubmed] PHST- 2026/10/06 22:00 [entrez] AID - S1477-5131(26)00572-3 [pii] AID - 10.1016/j.jpurol.2026.106293 [doi] PST - aheadofprint SO - J Pediatr Urol. 2026 Sep 21:106293. doi: 10.1016/j.jpurol.2026.106293. PMID- 42837523 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261008 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 6 TI - Remote Longitudinal Tracking of Sleep, Depression, and Cognition Across Early Adolescence: Protocol for a Longitudinal Observational Study. PG - e86345 LID - 10.2196/86345 [doi] LID - e86345 AB - BACKGROUND: Depression in adolescents is a growing public health concern, with 3.5 million youth in the United States experiencing a depressive episode each year. When symptoms emerge in early adolescence, they can have lasting psychological, physical, and cognitive consequences, highlighting the urgent need for proactive intervention. Insufficient sleep-characterized by short duration, irregular timing, and poor quality-is bidirectionally linked to depression and associated with impaired cognitive performance. OBJECTIVE: This protocol provides the map for a study tracking sleep patterns and neurophysiology, as well as a range of depressive symptoms, and their dynamic interaction in shaping longitudinal cognitive trajectories. METHODS: Fifty-six youth aged 9 to 13 (mean 11.01, SD 1.39) years were enrolled in a longitudinal measurement burst design comprising 4 assessment waves at baseline, 4, 8, and 12 months. We recruited a sample of youth with a range of depressive symptom severity. Each wave included 7 consecutive days of monitoring during which participants used a personalized mobile health (mHealth) platform, HowRU app, developed by the study team, to report daily sleep patterns, thrice-daily ecological momentary assessments (EMAs), and completed a series of cognitive tasks. Youth and parents also completed validated psychosocial questionnaires to assess mood, behavioral concerns, mental health, and sleep. Sleep and physical activity were monitored remotely using a Garmin VivoSmart 5 watch and Interaxon Muse S headbands. Sleep-dependent cognitive performance was assessed with 2 declarative memory tasks (Word-Pair Associates task [WPA] and Minecraft Memory and Navigation [MMN] task), a procedural memory task (Motor Sequence task), and 2 executive functioning tasks (Operation Span [OSpan] task and Rule Switch task [RST]). For the memory tasks, participants completed training and immediate testing in the evening, followed by a retention test the following morning. The OSpan task and Rule Switch were administered twice daily (morning and evening). For all tasks, stimuli were randomized and counterbalanced across participants and testing sessions. RESULTS: Funding was obtained from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant K08 HD107161), with a budget period of August 1, 2022, to July 31, 2027. Participant enrollment occurred May 2023 through October 2024. Data collection began in July 2023 and was completed in October 2025. Study participant retention and adherence rates for sleep diaries, cognitive tasks, and questionnaires were high. Primary outcomes of the study are anticipated to be published in fall 2026. CONCLUSIONS: This protocol provides a robust and reproducible framework to longitudinally track youth with a range of depressive symptoms in the real world using mHealth platforms and wearable technology. Potential findings can support the identification of key developmental periods of vulnerability and resilience in youth, inform future sleep-based interventions to promote mental health, and optimize cognitive outcomes across early adolescence. CI - (c) Katharine C Simon, Lia Galut, Spencer Polk, Shun Iwata, Weining Shen, Mahyar Abbasian, Amir Rahmani, Uma Rao, Jessica L Borelli, Sara C Mednick. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Simon, Katharine C AU - Simon KC AUID- ORCID: 0000-0001-8149-4636 AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. FAU - Galut, Lia AU - Galut L AUID- ORCID: 0009-0003-0936-4441 AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. FAU - Polk, Spencer AU - Polk S AUID- ORCID: 0009-0008-1878-2078 AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. FAU - Iwata, Shun AU - Iwata S AUID- ORCID: 0009-0002-2578-8247 AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. FAU - Shen, Weining AU - Shen W AUID- ORCID: 0000-0003-3137-1085 AD - Department of Statistics, University of California, Irvine, Irvine, CA, United States. FAU - Abbasian, Mahyar AU - Abbasian M AUID- ORCID: 0009-0000-8448-3158 AD - Department of Computer Science, University of California, Irvine, Irvine, CA, United States. FAU - Rahmani, Amir AU - Rahmani A AUID- ORCID: 0000-0003-0725-1155 AD - School of Nursing, University of California, Irvine, Irvine, CA, United States. FAU - Rao, Uma AU - Rao U AUID- ORCID: 0000-0003-2191-279X AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. AD - Deparment of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Irvine, CA, United States. AD - Department of Psychology, University of California, Irvine, Irvine, CA, United States. FAU - Borelli, Jessica L AU - Borelli JL AUID- ORCID: 0000-0001-8471-6732 AD - Department of Psychology, University of California, Irvine, Irvine, CA, United States. FAU - Mednick, Sara C AU - Mednick SC AUID- ORCID: 0000-0002-0906-3097 AD - Department of Cognitive Science, University of California, Irvine, Irvine, CA, United States. LA - eng GR - K08 HD107161/HD/NICHD NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20261006 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Cognition/physiology MH - *Depression/psychology/epidemiology MH - Ecological Momentary Assessment MH - Longitudinal Studies MH - *Sleep/physiology MH - Observational Studies as Topic PMC - PMC13641314 OTO - NOTNLM OT - cognition OT - depression OT - development OT - mobile health OT - remote research OT - sleep OT - wearable technology COIS- Conflicts of Interest: None declared. EDAT- 2026/10/06 17:31 MHDA- 2026/10/06 17:32 PMCR- 2026/10/06 CRDT- 2026/10/06 15:04 PHST- 2025/10/22 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/10/06 17:32 [medline] PHST- 2026/10/06 17:31 [pubmed] PHST- 2026/10/06 15:04 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - v15i1e86345 [pii] AID - 86345 [pii] AID - 10.2196/86345 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 6;15:e86345. doi: 10.2196/86345. PMID- 42837391 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261008 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Gameful experience, exercise identity, and exercise adherence among Chinese university students: A moderated chain mediation model. PG - e0353100 LID - 10.1371/journal.pone.0353100 [doi] LID - e0353100 AB - BACKGROUND: Gamified fitness applications have grown in popularity, yet it remains unclear how gameful experience, defined as users' subjective perception of game-like engagement during app-supported exercise, is associated with exercise adherence. METHODS: A cross-sectional survey was conducted among N = 300 Chinese university students who were active users of gamified fitness applications. Data were collected via an online questionnaire platform (Questionnaire Star) from March 5 to April 5, 2026. Participants completed validated measures of gameful experience (GAMEX), exercise identity (EI), exercise habit formation (EHF), intolerance of uncertainty (IU), and exercise adherence (EA). A moderated chain mediation model was tested using hierarchical regression analysis and bias-corrected bootstrap resampling (5,000 iterations). An indirect effect was considered statistically different from zero when its 95% confidence interval excluded zero. RESULTS: Gameful experience was positively associated with exercise adherence ([Formula: see text] = .264, p < .001). The observed associations were consistent with three indirect pathways: GAMEX [Formula: see text] EI [Formula: see text] EA (effect = .065, 95% CI [.020, .114]); GAMEX [Formula: see text] EHF [Formula: see text] EA (effect = .043, 95% CI [.002, .087]); and GAMEX [Formula: see text] EI [Formula: see text] EHF [Formula: see text] EA (effect = .085, 95% CI [.054, .123]). IU moderated the GAMEX-EI association ([Formula: see text] = .237, p < .001, [Formula: see text] = .036); the estimated chain indirect effect ranged from .034 (95% CI [.001, .072]) at low IU to .136 (95% CI [.080, .201]) at high IU. These estimates describe conditional associations and do not establish causal or temporal ordering. CONCLUSIONS: The findings are consistent with the hypothesized ordering of gameful experience, exercise identity, exercise habit formation, and adherence, while alternative causal orderings remain possible. The moderation result suggests that IU may be a useful boundary condition to examine in longitudinal and experimental studies of identity-supportive app features. CI - Copyright: (c) 2026 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Song, Jingjing AU - Song J AUID- ORCID: 0009-0007-3088-8900 AD - College of Physical Education and Health Management, Chongqing University of Education, Chongqing, China. FAU - Li, Jiaying AU - Li J AD - School of Physical Education, Chongqing University of Posts and Telecommunications, Chongqing, China. FAU - Li, Dan AU - Li D AD - School of Physical Education, Wuhan University of Science and Technology, Wuhan, Hubei, China. LA - eng PT - Journal Article DEP - 20261006 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Exercise/psychology MH - *Students/psychology MH - Male MH - Universities MH - Young Adult MH - Cross-Sectional Studies MH - China MH - Surveys and Questionnaires MH - *Video Games/psychology MH - Adult MH - Adolescent PMC - PMC13641342 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/06 17:31 MHDA- 2026/10/06 17:32 PMCR- 2026/10/06 CRDT- 2026/10/06 13:45 PHST- 2026/06/18 00:00 [received] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/06 17:32 [medline] PHST- 2026/10/06 17:31 [pubmed] PHST- 2026/10/06 13:45 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - PONE-D-26-28180 [pii] AID - 10.1371/journal.pone.0353100 [doi] PST - epublish SO - PLoS One. 2026 Oct 6;21(10):e0353100. doi: 10.1371/journal.pone.0353100. eCollection 2026. PMID- 42837008 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 6 TI - Evaluation of subclinical organ involvement with ultrasound elastography in childhood familial Mediterranean fever: relationships with disease activity, inflammatory markers, colchicine response, and genotype. LID - 806 [pii] LID - 10.1007/s00431-026-07408-1 [doi] AB - This study evaluates multiorgan shear-wave elastography (SWE) in children with familial Mediterranean fever (FMF) during attack-free periods and examines associations with clinical and inflammatory parameters. In this single-center, retrospective cross-sectional case-control study, SWE measurements of the liver, spleen, bilateral kidneys, pancreas, four mesenteric fat regions, and bilateral thyroid lobes were evaluated in 75 children with FMF and 52 matched healthy controls. Adjusted linear regression, generalized estimating equation (GEE), and Benjamini-Hochberg correction were applied. The cohort included 127 children; age, sex, weight, height, and BMI were comparable between groups. After adjustment for age, sex, and BMI, FMF patients showed higher SWE values at all 11 sites: liver (beta = 3.25 kPa; 95% CI, 2.55-3.95), right kidney (beta = 0.94 kPa; 95% CI, 0.31-1.57), left kidney (beta = 1.15 kPa; 95% CI, 0.57-1.74), spleen (beta = 1.24 kPa; 95% CI, 0.55-1.93), pancreas (beta = 0.88 kPa; 95% CI, 0.21-1.55), mesenteric fat regions (beta range, 1.43-2.06 kPa), right thyroid lobe (beta = 1.62 kPa; 95% CI, 0.73-2.51), and left thyroid lobe (beta = 2.94 kPa; 95% CI, 2.05-3.83). Repeated-measures GEE showed an overall adjusted FMF-control difference of 1.71 kPa and a significant group x organ-site interaction. Exploratory analyses showed no FDR-significant associations with disease duration, diagnostic delay, ISSF score, attack-free CRP/ESR, colchicine responsiveness, or M694V/M694V genotype. CONCLUSION: Children with FMF had higher multiorgan and mesenteric fat SWE-derived stiffness during attack-free periods. Multiorgan SWE may help evaluate subclinical tissue-level changes in pediatric FMF, but the cross-sectional design, lack of histopathologic validation, and exploratory subgroup analyses preclude causal or therapeutic conclusions. WHAT IS KNOWN: * Familial Mediterranean fever may be associated with persistent subclinical inflammation during attack-free periods. * Shear-wave elastography can noninvasively quantify tissue stiffness. WHAT IS NEW: * Children with FMF showed higher liver, spleen, kidney, pancreas, thyroid, and mesenteric fat stiffness than controls. * These differences persisted after adjustment for age, sex, and BMI. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Uslu, Hande AU - Uslu H AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. hande.uslu@kocaeli.edu.tr. FAU - Tosun, Mesude AU - Tosun M AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Sahin, Nihal AU - Sahin N AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Ozaslan, Nebahat Zeynep AU - Ozaslan NZ AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Oksel, Betul AU - Oksel B AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Aydin, Duygu AU - Aydin D AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Apaydin, Hulusi Ferhat AU - Apaydin HF AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Altin, Ece Devrim AU - Altin ED AD - Department of Radiology, Sakarya Yenikent State Hospital, Sakarya, Turkey. FAU - Sonmez, Hafize Emine AU - Sonmez HE AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. LA - eng PT - Journal Article DEP - 20261006 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - SML2Y3J35T (Colchicine) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Familial Mediterranean Fever/drug therapy/diagnostic imaging/genetics MH - Female MH - Male MH - Child MH - *Elasticity Imaging Techniques/methods MH - Cross-Sectional Studies MH - Retrospective Studies MH - Case-Control Studies MH - *Colchicine/therapeutic use MH - Adolescent MH - Genotype MH - Pancreas/diagnostic imaging MH - Child, Preschool MH - Biomarkers/blood MH - Liver/diagnostic imaging MH - Spleen/diagnostic imaging MH - Kidney/diagnostic imaging MH - Thyroid Gland/diagnostic imaging OTO - NOTNLM OT - Colchicine resistance OT - Familial Mediterranean fever OT - Multiorgan ultrasonography OT - Pediatric OT - Shear-wave elastography COIS- Declarations. Ethics approval: The study protocol was approved by the Local Research Ethics Committee (Approval No. 2026/137) and was conducted in accordance with the principles of the Declaration of Helsinki. Informed consent: The requirement for written informed consent was waived by the Local Research Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/06 17:31 MHDA- 2026/10/06 17:32 CRDT- 2026/10/06 11:16 PHST- 2026/06/23 00:00 [received] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/08/27 00:00 [revised] PHST- 2026/10/06 17:32 [medline] PHST- 2026/10/06 17:31 [pubmed] PHST- 2026/10/06 11:16 [entrez] AID - 10.1007/s00431-026-07408-1 [pii] AID - 10.1007/s00431-026-07408-1 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 6;185(11):806. doi: 10.1007/s00431-026-07408-1. PMID- 42836182 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261007 IS - 1177-8881 (Electronic) IS - 1177-8881 (Linking) VI - 20 DP - 2026 TI - Optimal Dosing Strategies for Remimazolam Across Diverse Patient Populations: A Clinical Narrative Review. PG - 644446 LID - 10.2147/DDDT.S644446 [doi] LID - 644446 AB - Remimazolam is an ultra-short-acting benzodiazepine that is hydrolyzed by carboxylesterase 1 (CES1) to the inactive metabolite CNS 7054. Since regulatory approval in 2020 it has been adopted globally for procedural sedation and general anesthesia, supported by an expanding evidence base of randomized trials, population pharmacokinetic/pharmacodynamic (PK/PD) modeling studies, dose-finding sequential-allocation analyses, and meta-analyses. Synthesizing 92 studies published between January 2020 and April 2026, this narrative review defines dose optimization across diverse populations. For adult procedural sedation, a fixed 5 mg initial bolus followed by 2.5 mg maintenance titrations achieves moderate sedation with a hemodynamic and respiratory profile that compares favorably with propofol, whereas general anesthesia requires an induction rate of 6 to 12 mg kg(-1) h(-1) followed by maintenance at 1.0-2.0 mg kg(-1) h(-1). Dosing demands a 25-30% reduction in the elderly (>/= 65 years), higher weight-adjusted requirements in pediatric patients (1-18 years), and lean or corrected body weight scalars in obesity, while severe hepatic impairment reduces clearance by approximately 38% and opioid co-administration yields a 15-63% synergistic reduction in effective concentrations. Several quantitative estimates, however, derive from single-center trials with fewer than 30 participants per arm that have not been externally validated. To help clinicians weigh these recommendations, each population-level dosing estimate is graded by the strength and external validity of its supporting evidence (A, B, or C); most special-population point estimates rest on single-center studies (grade C) and are best regarded as starting points rather than established standards. Crucially, the halted Japanese Phase II intensive care unit trial (ONO-2745-04) serves as a key safety counter-narrative: continuous infusions exceeding 24 hours in critically ill patients may be associated with drug accumulation and delayed emergence, suggesting that organ-independent clearance may not be guaranteed when CES1 activity is compromised. Major evidence gaps persist for infants under one year of age, long-duration anesthesia, CES1 polymorphisms, and non-East-Asian populations. CI - (c) 2026 Illias et al. FAU - Illias, Amina M AU - Illias AM AUID- ORCID: 0009-0002-9430-3776 AD - Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Tsai, Yung-Fong AU - Tsai YF AUID- ORCID: 0000-0002-3121-4840 AD - Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Wu, Shao-Chun AU - Wu SC AUID- ORCID: 0000-0002-0984-6921 AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. AD - Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. LA - eng PT - Journal Article PT - Review DEP - 20261001 PL - New Zealand TA - Drug Des Devel Ther JT - Drug design, development and therapy JID - 101475745 RN - 7V4A8U16MB (remimazolam) RN - 12794-10-4 (Benzodiazepines) RN - 0 (Hypnotics and Sedatives) SB - IM MH - Humans MH - *Benzodiazepines/administration & dosage/pharmacokinetics MH - *Hypnotics and Sedatives/administration & dosage/pharmacokinetics MH - Dose-Response Relationship, Drug PMC - PMC13637680 OAB - Remimazolam is a fast-acting sedative that anesthesiologists now use worldwide for short procedures and for general anesthesia. The body breaks it down rapidly with an enzyme called carboxylesterase 1, which is found mainly in liver cells but works independently of the slower liver pathways and the kidneys that clear most other sedatives, so doctors expected the dose to be easy to predict. In practice, the recommended dose still varies widely between different types of patients, and it has been hard for clinicians to know which numbers to trust. We searched the published research up to April 2026 and brought together 92 studies. We compared the doses used in adults, older people, children, people carrying extra weight, and people whose liver or kidneys do not work well. We also graded how strong the evidence behind each recommendation is. We found that older patients need roughly a quarter to a third less drug, children need more per kilogram of body weight, and much less drug is needed when a strong painkiller is given at the same time. We also found that the drug can build up and delay waking when it is given for more than a day to patients who are seriously ill, so its usual advantage over other sedatives may not apply to them. Many of the published dose figures come from single hospitals and small groups of patients, so clinicians should treat them as sensible starting points and adjust the dose for each patient rather than follow them as fixed rules. OABL- eng OTO - NOTNLM OT - dosing OT - pharmacodynamics OT - population pharmacokinetics OT - procedural sedation OT - remimazolam OT - special populations COIS- The authors report no conflicts of interest in this work. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/10/01 CRDT- 2026/10/06 07:28 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 07:28 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 644446 [pii] AID - 10.2147/DDDT.S644446 [doi] PST - epublish SO - Drug Des Devel Ther. 2026 Oct 1;20:644446. doi: 10.2147/DDDT.S644446. eCollection 2026. PMID- 42836153 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 1680-5348 (Electronic) IS - 1020-4989 (Print) IS - 1020-4989 (Linking) VI - 50 DP - 2026 TI - Body weight perception and body self-esteem in adolescents with overweight or obesity in Costa Rica: challenges for public health policy. PG - e80 LID - 10.26633/RPSP.2026.80 [doi] LID - e80 AB - OBJECTIVE: This study estimates the prevalence of weight misperception among Costa Rican adolescents in general and examines its association with body esteem and weight-control behaviors to inform public health policy. METHODS: The authors analyzed cross-sectional data collected in 2017 from a probabilistic sample of 818 adolescents aged 13-18 years enrolled in public and private secondary schools in urban and rural areas of the province of San Jose, Costa Rica. Weight and height were measured by trained nutritionists and classified using World Health Organization body mass index (BMI)-for-age standards. Perceived weight status was assessed using culturally appropriate response categories adapted from the Youth Risk Behavior Survey and refined through a pilot study. Body esteem and weight-control behaviors were measured using validated survey instruments. RESULTS: Among adolescents with overweight or obesity, 59% underestimated their weight, most commonly perceiving themselves as having an "adequate weight." Weight underestimation was associated with higher body esteem and lower engagement in weight-control behaviors after adjustment for key sociodemographic characteristics. CONCLUSION: By contributing evidence from a Latin American context-where research on adolescent weight perception remains scarce-this study enhances understanding of how excess weight is perceived during adolescence in settings where overweight is highly prevalent and supports public policy approaches that prioritize healthy eating and active living from adolescence. FAU - Monge-Rojas, Rafael AU - Monge-Rojas R AD - Nutrition and Health Unit Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA) Ministry of Health Tres Rios 4-2250 Costa Rica Nutrition and Health Unit, Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA), Ministry of Health, Tres Rios 4-2250, Costa Rica. FAU - Smith-Castro, Vanessa AU - Smith-Castro V AD - Psychological Research Institute University of Costa Rica City of Research Montes de Oca 11501-2060 Costa Rica Psychological Research Institute, University of Costa Rica, City of Research, Montes de Oca 11501-2060, Costa Rica. FAU - Vargas-Quesada, Rulaman AU - Vargas-Quesada R AD - Nutrition and Health Unit Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA) Ministry of Health Tres Rios 4-2250 Costa Rica Nutrition and Health Unit, Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA), Ministry of Health, Tres Rios 4-2250, Costa Rica. LA - eng PT - Journal Article DEP - 20261005 PL - United States TA - Rev Panam Salud Publica JT - Revista panamericana de salud publica = Pan American journal of public health JID - 9705400 PMC - PMC13637699 OTO - NOTNLM OT - Adolescent OT - Latin America OT - body weight OT - obesity OT - overweight OT - weight perception COIS- Conflicts of interests. None declared. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/10/05 CRDT- 2026/10/06 07:24 PHST- 2026/02/10 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 07:24 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - RPSP.2026.80 [pii] AID - 10.26633/RPSP.2026.80 [doi] PST - epublish SO - Rev Panam Salud Publica. 2026 Oct 5;50:e80. doi: 10.26633/RPSP.2026.80. eCollection 2026. PMID- 42835958 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2772-4875 (Electronic) IS - 2772-4875 (Linking) VI - 31 DP - 2026 Dec TI - Early-onset atherosclerotic cardiovascular disease in young adults: Lifestyle, environmental, and psychosocial risk factors. PG - 200714 LID - 10.1016/j.ijcrp.2026.200714 [doi] LID - 200714 AB - Early-onset atherosclerotic cardiovascular disease (ASCVD) must be distinguished from cardiovascular risk factors and subclinical vascular abnormalities that may arise at younger ages. This narrative review critically examines lifestyle, environmental, metabolic, psychosocial, and inherited determinants among adolescents (10-19 years), young adults (20-39 years), and selected adults aged 40-54 years who remain within commonly used thresholds for premature events. The 40-54-year band is included selectively to bridge younger-adult prevention with guideline-based adult risk assessment and is not intended to redefine the upper age limit of premature ASCVD. Epidemiological evidence demonstrates a substantial burden of cardiovascular disease (CVD) among people aged 15-39 years; however, evidence of increasing clinically manifest ASCVD is less consistent than evidence of rising obesity, hypertension, dyslipidemia, diabetes, nicotine exposure, and subclinical vascular injury. Established causal drivers, including cumulative exposure to apolipoprotein B-containing lipoproteins and cigarette smoking, are distinguished from predominantly associative evidence concerning sleep disruption, psychosocial stress, e-cigarette use, and air pollution. Prevention should combine population-level health promotion with age-appropriate clinical risk assessment, including lipid screening and measurement of lipoprotein(a) at least once in adulthood, with additional targeted evaluation for familial hypercholesterolemia, a family history of premature ASCVD, obesity, hypertension, diabetes, chronic kidney disease, and smoking or vaping. Coronary artery calcium scoring and carotid imaging are not recommended as universal screening tests for asymptomatic young people, although they may refine clinical decisions in carefully selected adults. Digital tools may support engagement but should complement, rather than replace, validated clinical care and public-health measures. CI - (c) 2026 The Authors. FAU - Khasanovna, Tukhtaeva Nigora AU - Khasanovna TN AD - "Propaedeutics of Internal Diseases No. 2", Tashkent State Medical University, Tashkent, Uzbekistan. FAU - Egamberdi Son, Babajanov Xudoybergan AU - Egamberdi Son BX AD - Tashkent State Medical University, Tashkent, Uzbekistan. LA - eng PT - Journal Article PT - Review DEP - 20260924 PL - Netherlands TA - Int J Cardiol Cardiovasc Risk Prev JT - International journal of cardiology. Cardiovascular risk and prevention JID - 9918282077306676 PMC - PMC13636304 OTO - NOTNLM OT - Atherosclerotic cardiovascular disease OT - Familial hypercholesterolemia OT - Premature cardiovascular disease OT - Prevention OT - Risk assessment OT - Young adults OT - lipoprotein(a) EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/24 CRDT- 2026/10/06 07:06 PHST- 2026/05/13 00:00 [received] PHST- 2026/09/18 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 07:06 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - S2772-4875(26)00144-3 [pii] AID - 200714 [pii] AID - 10.1016/j.ijcrp.2026.200714 [doi] PST - epublish SO - Int J Cardiol Cardiovasc Risk Prev. 2026 Sep 24;31:200714. doi: 10.1016/j.ijcrp.2026.200714. eCollection 2026 Dec. PMID- 42835802 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Mediterranean diet, eating behaviours, and nutritional intervention in childhood obesity: what works, where, and for whom-a narrative review. PG - 1892494 LID - 10.3389/fnut.2026.1892494 [doi] LID - 1892494 AB - Childhood obesity is a leading public health challenge with rising global prevalence and significant impacts on cardiometabolic health extending into adulthood. Lifestyle intervention, with nutrition as its central component, is the main point of paediatric obesity management, yet the evidence base remains fragmented across regions, instruments, and clinical models. This narrative review synthesises European evidence on Mediterranean diet (MD) adherence assessment, multidisciplinary intervention outcomes, and global comparative patterns in paediatric obesity management. Among dietary patterns, the Mediterranean diet (MD) remains the most evidence-supported framework for cardiometabolic prevention in children and adolescents. KIDMED, a 16-item validated instrument, has been adapted for multiple European paediatric populations and consistently identifies low legume, whole grain, and extra-virgin olive oil intake as the principal adherence gaps associated with a higher body mass index (BMI) Z-score, as well as a higher age- and sex-specific BMI percentile. The Children's Eating Behaviour Questionnaire (CEBQ) provides a complementary behavioural marker with food-approach subscales positively associated with BMI Z-score and food-avoidance subscales inversely associated, a pattern replicated across European, Latin American, and Middle Eastern cohorts. Structured multidisciplinary interventions consistently produce modest reductions in BMI Z-score, typically between 0.10 and 0.25 units over 3 to 12 months. The strongest predictors of response are younger age, lower baseline obesity severity, breakfast adherence, and the absence of obese parents. Low KIDMED score additionally functions as a screening signal for paediatric Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD). Continental comparisons suggest that dietary-quality predictors of paediatric obesity are broadly consistent across regions. However, the feasibility of Mediterranean-style approaches varies substantially with local food availability, culinary traditions and economic access, so cross-cultural application of KIDMED-based screening requires careful local adaptation. The review concludes that routine integration of KIDMED and CEBQ within structured multidisciplinary pathways represents an evidence-informed, implementation-ready step for pediatric obesity care, particularly in under-studied Central and Eastern Europe. CI - Copyright (c) 2026 Bober and Gaszynska. FAU - Bober, Julia AU - Bober J AD - International Doctoral School, Medical University of Lodz, Lodz, Poland. AD - Department of Nutrition and Epidemiology, Medical University of Lodz, Lodz, Poland. FAU - Gaszynska, Ewelina AU - Gaszynska E AD - Department of Nutrition and Epidemiology, Medical University of Lodz, Lodz, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260921 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13635886 OTO - NOTNLM OT - CEBQ OT - KIDMED OT - Mediterranean diet OT - childhood obesity OT - lifestyle intervention COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/21 CRDT- 2026/10/06 06:52 PHST- 2026/05/27 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 06:52 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1892494 [doi] PST - epublish SO - Front Nutr. 2026 Sep 21;13:1892494. doi: 10.3389/fnut.2026.1892494. eCollection 2026. PMID- 42835418 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Feasibility of FnNO measurement in preschoolers and development of predictive models. PG - 1891740 LID - 10.3389/fped.2026.1891740 [doi] LID - 1891740 AB - BACKGROUND: Fractional nasal exhaled nitric oxide (FnNO) is a valuable biomarker of upper airway mucosal inflammation, but its clinical application in preschoolers is limited by uncertain compliance and a lack of reference data. This study aimed to evaluate the feasibility of standardized FnNO measurement in children aged 3-6 years, identify independent predictors of test cooperation and first-attempt success to build exploratory predictive models, and provide preliminary distribution estimates of FnNO in healthy preschoolers. METHODS: A total of 148 preschoolers aged 3-6 years were enrolled. Test completion and first-attempt success rates were recorded. Multivariable logistic regression was used to identify independent predictors of compliance. Exploratory predictive models were developed and evaluated using receiver operating characteristic (ROC) analysis with internal bootstrap validation. FnNO distribution characteristics were analyzed in both the general cohort and a healthy subgroup. RESULTS: The overall test completion rate was 82.4% (122/148), and the first-attempt success rate was 76.2% (77/101). Multivariable analysis demonstrated that female sex (OR = 4.853, P = 0.004) and greater height (OR = 1.216, P = 0.000) were independent predictors of test completion. Age was the sole independent predictor of first-attempt success (OR = 2.299, P = 0.001). The predictive model for test completion (sex and height) achieved an area under the curve (AUC) of 0.870, while the first-attempt success model (age and BMI) yielded an AUC of 0.749. The median FnNO level was 315.50 ppb (IQR: 168.00-410.00 ppb) across the overall cohort and 324.00 ppb (IQR: 221.00-378.50 ppb) in the healthy subgroup (n = 81). CONCLUSIONS: Standardized FnNO measurement is feasible in preschool children. Height, sex, and age are key factors influencing test cooperation. The proposed predictive models offer exploratory statistical tools for population stratification in research contexts, though prospective clinical validation remains necessary. This study establishes preliminary reference estimates for FnNO in Chinese preschoolers. CI - (c) 2026 Wang, Lin, Wang and Li. FAU - Wang, Yue AU - Wang Y AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. FAU - Lin, Qianqian AU - Lin Q AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. FAU - Wang, Haoyu AU - Wang H AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. FAU - Li, Yanchun AU - Li Y AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. LA - eng PT - Journal Article DEP - 20260921 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13635358 OTO - NOTNLM OT - FnNO OT - children OT - compliance OT - feasibility OT - predictive model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/21 CRDT- 2026/10/06 06:14 PHST- 2026/05/26 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 06:14 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fped.2026.1891740 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 21;14:1891740. doi: 10.3389/fped.2026.1891740. eCollection 2026. PMID- 42835024 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Diet quality in pediatric migraine and the educational quality of related short-form videos: a cross-sectional study and content analysis. PG - 1934926 LID - 10.3389/fnut.2026.1934926 [doi] LID - 1934926 AB - BACKGROUND: Diet quality has been associated with headache burden and psychosocial outcomes in children with migraine, while caregivers increasingly use short-form videos for dietary and lifestyle advice. However, evidence on overall diet quality and related video quality remains limited. METHODS: This study included 180 children aged 7-18 years with migraine. Diet quality was assessed using the Chinese Children Dietary Index (CCDI). Participants were divided at the median CCDI score of 117.7 into low- and high-CCDI groups (n = 90 each). Between-group comparisons included Pediatric Migraine Disability Assessment (PedMIDAS) scores, headache characteristics, analgesic use, caregiver burden, and anxiety and depressive symptoms. Multivariable regression was used to examine adjusted associations between CCDI scores and clinical outcomes. Caregiver use of short-form videos was also surveyed. In addition, 150 videos on dietary and lifestyle management of pediatric migraine from Douyin, Kuaishou, and Xiaohongshu were analyzed for educational quality, reliability, and actionability. RESULTS: The high-CCDI group had lower PedMIDAS scores than the low-CCDI group (29.54 +/- 17.20 vs. 41.96 +/- 14.72), fewer headache days over 28 days [6.00 (4.00, 8.00) vs. 9.00 (8.00, 11.00)], lower pain intensity, and fewer days of analgesic use (all p < 0.001). Caregiver burden and anxiety and depression scores were also lower (all p < 0.05). After adjustment, higher CCDI scores remained associated with lower PedMIDAS scores, fewer headache days, lower pain intensity, fewer days of analgesic use, and lower caregiver burden. Diet and lifestyle management was the most frequently searched topic (30.6%), yet only 34.4% of caregivers fully verified video recommendations with a physician. Although 90.0% of videos provided recommendations concordant with clinical guidelines or evidence-based recommendations, reliability, actionability, and nutrition follow-up remained limited; nutrition follow-up was addressed in only 23.33% of videos. CONCLUSION: Higher overall diet quality was associated with lower migraine burden and caregiver burden in children with migraine. These findings support the relevance of overall dietary assessment, while prospective studies are needed to clarify temporal and causal relationships. Short-form videos are an important source of dietary and lifestyle information for caregivers, but their reliability, actionability, and follow-up content require improvement. CI - Copyright (c) 2026 Li, Liu, Jiang, Xu, Zhou and Xu. FAU - Li, Haisu AU - Li H AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Liu, Lan AU - Liu L AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Jiang, Jiayi AU - Jiang J AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Xu, Yumei AU - Xu Y AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Zhou, Dan AU - Zhou D AD - Department of Anesthesiology, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China. FAU - Xu, Ying AU - Xu Y AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. LA - eng PT - Journal Article DEP - 20260921 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13634853 OTO - NOTNLM OT - Chinese Children Dietary Index OT - diet quality OT - dietary management OT - pediatric migraine OT - short-form videos COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/21 CRDT- 2026/10/06 05:17 PHST- 2026/07/11 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 05:17 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1934926 [doi] PST - epublish SO - Front Nutr. 2026 Sep 21;13:1934926. doi: 10.3389/fnut.2026.1934926. eCollection 2026. PMID- 42834918 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Associations between perceived stress, sleep quality, and suicidal ideation among Chinese graduating-grade secondary school students: a multi-method study of the moderating role of physical exercise. PG - 1934268 LID - 10.3389/fpubh.2026.1934268 [doi] LID - 1934268 AB - OBJECTIVE: This study aimed to investigate the associations among perceived stress, sleep quality, physical exercise, and suicidal ideation among Chinese graduating-grade secondary school students. Specifically, this study examined whether sleep quality mediated the association between perceived stress and suicidal ideation and whether physical exercise moderated these relationships. In addition, machine-learning prediction models and network analysis were applied to identify important predictors and interconnected symptoms associated with suicidal ideation. METHODS: A cross-sectional survey was conducted among ninth- and twelfth-grade students from 13 secondary schools in Yunnan Province, China. A total of 4,372 valid questionnaires were collected. Participants completed measures of perceived stress, sleep quality, suicidal ideation, and physical exercise. Mediation and moderated mediation analyses were conducted using PROCESS models after adjusting for demographic covariates. Furthermore, ridge regression and gradient boosting tree models were used to predict suicidal ideation, with Shapley additive explanations (SHAP) applied to evaluate predictor contributions. Network analysis was conducted to explore central and bridge nodes among study variables. RESULTS: Perceived stress was positively associated with suicidal ideation, and sleep quality partially mediated this association. Physical exercise significantly moderated the direct association between perceived stress and suicidal ideation as well as the association between sleep quality problems and suicidal ideation. Specifically, higher levels of physical exercise weakened the positive relationships between perceived stress, sleep problems, and suicidal ideation. Machine-learning analyses showed that sleep quality problems, perceived stress, physical exercise, and their interaction terms contributed substantially to the prediction of suicidal ideation, with both models achieving an R(2) of approximately 0.41 in the hold-out test set. Network analysis further identified subjective sleep quality, sleep latency, sleep disturbances, stress-coping burden, and physical exercise frequency as highly connected nodes within the network. CONCLUSION: Among Chinese graduating-grade secondary school students, perceived stress, poor sleep quality, and suicidal ideation were closely interconnected, whereas physical exercise appeared to attenuate these risk associations. Integrating stress management, sleep improvement strategies, and regular physical exercise into school-based mental health programs may provide potential approaches for suicide risk prevention among adolescents. CI - Copyright (c) 2026 Yin, Peng, Chen, Lin and Liang. FAU - Yin, Tian AU - Yin T AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Peng, Yanfeng AU - Peng Y AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Chen, Longjiang AU - Chen L AD - School of Physical Education, Yunnan Normal University, Kunming, Yunnan, China. FAU - Lin, Xiaoying AU - Lin X AD - The Department of Pharmacy, The Second People's Hospital of Longgang District, Shenzhen, China. FAU - Liang, Feiqing AU - Liang F AD - The Department of Pharmacy, The Second People's Hospital of Longgang District, Shenzhen, China. LA - eng PT - Journal Article DEP - 20260921 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Female MH - China/epidemiology MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - *Suicidal Ideation MH - *Students/psychology/statistics & numerical data MH - Subjective Stress MH - *Exercise/psychology MH - *Sleep Quality MH - Surveys and Questionnaires MH - Schools MH - *Stress, Psychological/epidemiology MH - East Asian People PMC - PMC13634819 OTO - NOTNLM OT - academic stress OT - adolescent mental health OT - high school students OT - machine learning OT - mediation OT - moderation OT - network analysis OT - perceived stress COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 05:29 MHDA- 2026/10/06 12:33 PMCR- 2026/09/21 CRDT- 2026/10/06 04:59 PHST- 2026/07/10 00:00 [received] PHST- 2026/08/11 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/06 12:33 [medline] PHST- 2026/10/06 05:29 [pubmed] PHST- 2026/10/06 04:59 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1934268 [doi] PST - epublish SO - Front Public Health. 2026 Sep 21;14:1934268. doi: 10.3389/fpubh.2026.1934268. eCollection 2026. PMID- 42833415 OWN - NLM STAT- Publisher LR - 20261010 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 76 DP - 2026 Oct 5 TI - Anthropometric profile, severity, and concordance of MUAC and BMI-for-age classification among clinically screened pediatric patients at a tertiary care hospital in south Rajasthan: A hospital-based cross-sectional study. PG - 105167 LID - S2405-4577(26)02264-3 [pii] LID - 10.1016/j.clnesp.2026.105167 [doi] AB - INTRODUCTION: Undernutrition remains a leading contributor to childhood morbidity and mortality in India, and southern Rajasthan - with a large rural and tribal catchment - carries a disproportionate burden. Data describing the anthropometric profile of malnourished children who actually reach tertiary care in this region are limited. AIM: To characterise the anthropometric profile and severity of malnutrition among children undergoing clinical screening at a tertiary care hospital in South Rajasthan, to classify nutritional status using age- and sex-specific WHO z-scores, to assess agreement between mid-upper arm circumference (MUAC) and BMI-for-age classification, and to examine associations between anthropometric, dietary, demographic and behavioural variables. MATERIALS AND METHODS: A hospital-based cross-sectional study was conducted in the Department of Pediatrics of a tertiary care teaching hospital in Udaipur, Rajasthan, over four months of data collection. One hundred and twenty-five children aged 6 months to 18 years, identified as malnourished on clinical screening, were enrolled by consecutive sampling. Weight, height, body mass index (BMI) and mid-upper arm circumference (MUAC) were measured by standard technique; habitual pre-illness dietary energy and protein intake were obtained by recall and compared with age-appropriate recommended allowances. Non-parametric tests, Chi-square, Spearman correlation and Cohen's kappa were used, with P < 0.05 considered significant. RESULTS: Of 125 children undergoing clinical screening (mean age 3.37 +/- 3.02 years; 59.2% male; 76.0% rural), age- and sex-specific WHO BMI-for-age z-scores (WHO Child Growth Standards for 6-60 months; WHO Growth Reference 2007 for 61-228 months) classified 31 (24.8%) as wasted and 78 (62.4%) as severely wasted, together 87.2%; 16 (12.8%) were normal. Mean BMI was 12.05 +/- 1.45 kg/m(2) and mean MUAC 12.77 +/- 2.23 cm. In the subgroup aged 6-59 months for whom WHO MUAC cut-offs are validated (n = 102), MUAC classified 31 (30.4%) as severe and 24 (23.5%) as moderate acute malnutrition; among the 91 children in this subgroup classified as wasted or severely wasted by BMI-for-age z-score, 42 (46.2%) had a MUAC value in the normal range. Agreement between MUAC and z-score-based BMI classification in this subgroup was negligible (linear-weighted kappa = 0.02; unweighted kappa = 0.03). Percentage calorie deficit correlated inversely with MUAC (rho = -0.608, P < 0.001), an association that persisted after adjusting for age (partial rho = -0.583, P < 0.001), but not with BMI. No demographic factor reached significance; age group approached it (P = 0.051). CONCLUSION: Among children undergoing clinical screening at this tertiary care centre in South Rajasthan, malnutrition was severe and predominantly acute on z-score-based BMI-for-age classification. Fixed MUAC cut-offs performed poorly outside the 6-59 month band for which they are validated, and a substantial proportion of children with acute malnutrition on BMI-for-age were not flagged by MUAC. These findings support the consideration of complementary anthropometric assessment - using MUAC alongside BMI/weight-for-height and age- and sex-specific WHO z-scores rather than raw cut-offs - particularly in primary and referral care settings serving a wide paediatric age range. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Kumar, Dinesh AU - Kumar D AD - Department of Pharmacology, Pacific College of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, 313001, India. Electronic address: 2016dineshkr@gmail.com. FAU - Singh, Anukrman AU - Singh A AD - Department of Pharmacology, Pacific College of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, 313001, India. FAU - More, S S AU - More SS AD - Department of Pediatrics, Pacific Medical College and Hospital, Udaipur, Rajasthan, 313001, India. LA - eng PT - Journal Article DEP - 20261005 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM OTO - NOTNLM OT - Anthropometry OT - Child nutrition disorders OT - Cross-sectional studies OT - Mid-upper arm circumference OT - Rajasthan OT - Wasting syndrome COIS- Conflicts of interest There are no conflicts of interest. EDAT- 2026/10/05 23:30 MHDA- 2026/10/05 23:30 CRDT- 2026/10/05 19:32 PHST- 2026/08/07 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/05 23:30 [pubmed] PHST- 2026/10/05 23:30 [medline] PHST- 2026/10/05 19:32 [entrez] AID - S2405-4577(26)02264-3 [pii] AID - 10.1016/j.clnesp.2026.105167 [doi] PST - aheadofprint SO - Clin Nutr ESPEN. 2026 Oct 5;76:105167. doi: 10.1016/j.clnesp.2026.105167. PMID- 42833305 OWN - NLM STAT- Publisher LR - 20261005 IS - 2589-5559 (Electronic) IS - 2589-5559 (Linking) DP - 2026 Oct 5 TI - Sex differences in MASLD and fitness improvement during a weight loss intervention for adolescents living with obesity. PG - 102059 LID - S2589-5559(26)00330-7 [pii] LID - 10.1016/j.jhepr.2026.102059 [doi] AB - BACKGROUND AND AIMS: The interplay between liver and muscle health is incompletely understood, especially in adolescents living with obesity. Cardiopulmonary exercise testing (CPET) evaluates cardiorespiratory fitness through peak oxygen uptake ( O(2)peak). The association of baseline cardiorespiratory fitness and metabolic dysfunction-associated steatotic liver disease (MASLD), and their longitudinal co-evolution during a lifestyle intervention, have not been studied in this population. METHODS: Adolescents with obesity receiving a lifestyle intervention in a residential setting were prospectively followed for 9 - 12 months. At baseline and after 6 months, MASLD was defined as a controlled-attenuation parameter >/= 248dB/m. Cardiorespiratory fitness and body composition were assessed at the start and throughout the trajectory. RESULTS: 142 adolescents (69 boys) were included. Relative O(2)peak was 37.9 (33.5 - 42.3) vs. 43.4 (39.7 - 49.8 ; p=0.004) mL∙kg(-1)∙min(-1) [LM] in boys with and without MASLD, and respectively 36.3 (31.7 - 43.2) vs. 41.3 (34.8 - 46.2 ; p=0.055) mL∙kg(-1)∙min(-1) [LM] in girls. Oxygen uptake efficiency slope (OUES) was respectively 40.6 (35.8 - 46.3) vs. 46.7 (41.6 - 53.8; p=0.011) in boys and 39.1 (34.7 - 45.1) vs. 44.2 (39.1 - 50.8 ; p=0.011) in girls. For boys with MASLD, initial relative O(2)peak was the lowest for those with persistent MASLD during the lifestyle trajectory (33.5; 30.5 - 36.6 mL∙kg(-1)∙min(-1) [LM]). During the lifestyle intervention, lean body mass (LM) was preserved in boys with MASLD resolution and girls without baseline MASLD, whereas boys with persistent MASLD and girls with baseline MASLD experienced LM losses of 7 - 9%. CONCLUSION: Lower baseline cardiorespiratory fitness, independent from (fat) mass, is associated with (persistent) MASLD during a residential lifestyle intervention. LM preservation during weight loss trajectories, with concomitant improvement of maximal oxygen uptake, are important therapeutic targets. IMPACT AND IMPLICATIONS: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common liver disease in children and adolescents worldwide. Although a better cardiorespiratory fitness at the start of a lifestyle intervention is linked with more weight loss, its association with cardiometabolic health and MASLD has not been assessed. A lower initial cardiorespiratory fitness was observed in adolescents with (persistent) MASLD, and in boys with an increased transient elastography. During the lifestyle intervention, boys and girls without MASLD or boys who experience MASLD resolution preserve their lean mass. Improvement of cardiorespiratory fitness and preservation of lean mass during a structured lifestyle intervention are important therapeutic targets, and sex-specific lifestyle interventions need to be developed and validated. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Buytaert, Maarten AU - Buytaert M AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium. FAU - Vandekerckhove, Kristof AU - Vandekerckhove K AD - Department of Pediatric Cardiology, Ghent University Hospital, Ghent, Belgium. FAU - Coomans, Ilse AU - Coomans I AD - Department of Pediatric Cardiology, Ghent University Hospital, Ghent, Belgium. FAU - Vangampelaere, Maxine AU - Vangampelaere M AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium. FAU - Dupont, Ellen AU - Dupont E AD - Medical Department, Zeepreventorium, De Haan, Belgium. FAU - Stalpaert, Silke AU - Stalpaert S AD - Medical Department, Zeepreventorium, De Haan, Belgium. FAU - Caen, Kevin AU - Caen K AD - Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium. FAU - Lefere, Sander AU - Lefere S AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium. FAU - De Bruyne, Ruth AU - De Bruyne R AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ghent University Hospital, Ghent, Belgium. Electronic address: ruth.debruyne@uzgent.be. LA - eng PT - Journal Article DEP - 20261005 PL - Netherlands TA - JHEP Rep JT - JHEP reports : innovation in hepatology JID - 101761237 SB - IM OTO - NOTNLM OT - cardiorespiratory fitness OT - lifestyle intervention OT - muscle-liver axis OT - pediatric MASLD OT - pediatric obesity EDAT- 2026/10/05 23:30 MHDA- 2026/10/05 23:30 CRDT- 2026/10/05 19:29 PHST- 2026/03/18 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/05 23:30 [medline] PHST- 2026/10/05 23:30 [pubmed] PHST- 2026/10/05 19:29 [entrez] AID - S2589-5559(26)00330-7 [pii] AID - 10.1016/j.jhepr.2026.102059 [doi] PST - aheadofprint SO - JHEP Rep. 2026 Oct 5:102059. doi: 10.1016/j.jhepr.2026.102059. PMID- 42832973 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 66 DP - 2026 Nov TI - Changes in circulating microRNAs and inflammatory proteins in children with celiac disease during the first year on a gluten-free diet. PG - 106806 LID - S0261-5614(26)00233-5 [pii] LID - 10.1016/j.clnu.2026.106806 [doi] AB - BACKGROUND & AIMS: In celiac disease (CD), mucosal recovery can only be assessed through biopsy, as current serological tests do not reliably reflect histological status or residual inflammation after gluten withdrawal. This limitation is particularly relevant in children, in whom invasive procedures are preferably avoided. Novel serum biomarkers may offer non-invasive and objective insights into intestinal damage, functional recovery, or persistent inflammation. This study aimed to characterize longitudinal changes in selected serum biomarkers from diagnosis through the first year on a gluten-free diet (GFD) and to assess their relationship with nutrient intake in pediatric CD. METHODS: 41 children with newly diagnosed CD were assessed at diagnosis (t0), 3 (t3) and 12 months (t12) after initiating a GFD in six hospitals of the Basque Country (Spain). Seven patients failed during the study and 34 finished. Serum inflammatory proteins, circulating microRNAs (miRNAs), citrulline and intestinal fatty acid-binding protein (FABP2) were measured. Dietary intake was evaluated using 3-day 24h food records. Time-point differences were tested with Wilcoxon test and correlations between variables with Spearman's correlation. RESULTS: After 12 months on a GFD, children with CD showed a statistically significant reduction in pro-inflammatory proteins, particularly in Interleukin-18 (IL-18), C-X-C motif chemokine ligand 11 (CXCL11) and matrix metalloproteinase 10 (MMP-10). In parallel, six circulating miRNAs were significantly altered. No significant changes were observed in FABP2 or citrulline levels. Micronutrient intake improved significantly over the study period, especially for vitamin B12, folate, iron, magnesium and iodine. Furthermore, significant associations were identified between some inflammatory proteins, miRNA and proteins and between micronutrient intake and proteins at different time points. CONCLUSIONS: Some serum biomarkers show statistically significant changes during a GFD and may be useful to monitor pediatric CD. In addition, nutritional intervention improves micronutrient intake in newly diagnosed children with CD. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Perez-Junkera, Gesala AU - Perez-Junkera G AD - GLUTEN3S Research Group, Pharmacy and Food Science Department, University of the Basque Country, Vitoria-Gasteiz, Spain; Bioaraba, Nutricion y Seguridad Alimentaria, Vitoria-Gasteiz, Spain. Electronic address: gesala.perez@ehu.eus. FAU - Altolaguirre, Naroa AU - Altolaguirre N AD - GLUTEN3S Research Group, Pharmacy and Food Science Department, University of the Basque Country, Vitoria-Gasteiz, Spain; Bioaraba, Nutricion y Seguridad Alimentaria, Vitoria-Gasteiz, Spain. Electronic address: naltolaguirre002@ikasle.ehu.eus. FAU - Lasa, Arrate AU - Lasa A AD - GLUTEN3S Research Group, Pharmacy and Food Science Department, University of the Basque Country, Vitoria-Gasteiz, Spain; Bioaraba, Nutricion y Seguridad Alimentaria, Vitoria-Gasteiz, Spain. Electronic address: arrate.lasa@ehu.eus. FAU - de la Calle, Estela AU - de la Calle E AD - Pediatric Gastroenterology, Hospital Universitario de Donostia, Donostia-San Sebastian, Spain. Electronic address: estela.delacallenavarro@osakidetza.eus. FAU - Simon, Edurne AU - Simon E AD - GLUTEN3S Research Group, Pharmacy and Food Science Department, University of the Basque Country, Vitoria-Gasteiz, Spain; Bioaraba, Nutricion y Seguridad Alimentaria, Vitoria-Gasteiz, Spain. Electronic address: edurne.simon@ehu.eus. FAU - Gomez-Aguililla, Sara AU - Gomez-Aguililla S AD - Laboratorio de Investigacion en Genetica de enfermedades complejas, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid 28040, Spain. Electronic address: gmz.sra@gmail.com. FAU - Nunez, Concepcion AU - Nunez C AD - Laboratorio de Investigacion en Genetica de enfermedades complejas, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid 28040, Spain; Redes de Investigacion Cooperativa Orientada a Resultados en Salud (RICORS), Madrid 28029, Spain. Electronic address: conchita.npardo@gmail.com. FAU - Churruca, Itziar AU - Churruca I AD - GLUTEN3S Research Group, Pharmacy and Food Science Department, University of the Basque Country, Vitoria-Gasteiz, Spain; Bioaraba, Nutricion y Seguridad Alimentaria, Vitoria-Gasteiz, Spain. Electronic address: itziar.txurruka@ehu.eus. FAU - Navarro, Virginia AU - Navarro V AD - GLUTEN3S Research Group, Pharmacy and Food Science Department, University of the Basque Country, Vitoria-Gasteiz, Spain; Bioaraba, Nutricion y Seguridad Alimentaria, Vitoria-Gasteiz, Spain. Electronic address: virginia.navarros@ehu.eus. FAU - Larretxi, Idoia AU - Larretxi I AD - GLUTEN3S Research Group, Pharmacy and Food Science Department, University of the Basque Country, Vitoria-Gasteiz, Spain; Bioaraba, Nutricion y Seguridad Alimentaria, Vitoria-Gasteiz, Spain. Electronic address: idoia.larrechi@ehu.eus. LA - eng PT - Journal Article DEP - 20260925 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 0 (Biomarkers) RN - 0 (Circulating MicroRNA) RN - 0 (Fatty Acid-Binding Proteins) RN - 0 (FABP2 protein, human) SB - IM MH - Humans MH - *Celiac Disease/diet therapy/blood MH - *Diet, Gluten-Free MH - Female MH - Male MH - Biomarkers/blood MH - Child MH - Child, Preschool MH - *Circulating MicroRNA/blood MH - Longitudinal Studies MH - Fatty Acid-Binding Proteins/blood MH - Spain MH - Inflammation/blood MH - Adolescent OTO - NOTNLM OT - Celiac OT - Children OT - Diet OT - Disease OT - Proteins OT - microRNAs COIS- Conflict of interest Authors have no conflicts of interest to disclose. EDAT- 2026/10/05 23:30 MHDA- 2026/10/28 23:26 CRDT- 2026/10/05 18:05 PHST- 2026/03/03 00:00 [received] PHST- 2026/09/01 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/28 23:26 [medline] PHST- 2026/10/05 23:30 [pubmed] PHST- 2026/10/05 18:05 [entrez] AID - S0261-5614(26)00233-5 [pii] AID - 10.1016/j.clnu.2026.106806 [doi] PST - ppublish SO - Clin Nutr. 2026 Nov;66:106806. doi: 10.1016/j.clnu.2026.106806. Epub 2026 Sep 25. PMID- 42832767 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261005 LR - 20261007 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Oct 5 TI - Online Lifestyle Support for Adolescents Undergoing Metabolic and Bariatric Surgery: Pilot Prospective Cohort Study. PG - e86816 LID - 10.2196/86816 [doi] LID - e86816 AB - BACKGROUND: Metabolic and bariatric surgery (MBS) is a safe and effective treatment for adolescents with severe obesity, yet no standardized lifestyle interventions exist to support sustained behavior change after MBS. OBJECTIVE: This pilot study assessed the feasibility and acceptability of TeenLyft, an online lifestyle support program for adolescents undergoing MBS, and explored preliminary clinical and safety outcomes to inform the design of a future randomized trial. METHODS: Adolescents aged 13 to 18 years were recruited from a tertiary care MBS center and enrolled in TeenLyft. The study was not powered or designed as a randomized controlled trial but rather as a pilot to guide future randomized controlled trial development. Feasibility domains included recruitment, retention, data completeness, intervention fidelity, and engagement, with predefined progression criteria of >/=80% enrollment, >/=70% retention, >/=70% data completeness, and >/=90% fidelity. Exploratory clinical and safety measures (weight, BMI, and cardiometabolic markers) were collected descriptively to confirm that participation was not associated with harm. RESULTS: Twenty-nine adolescents (mean age 15.9 years, SD 1.1; n=22, 75.9% female; n=13, 44.8% Hispanic; mean BMI 47.8, SD 7.3 kg/m(2)) were enrolled, representing 145% of the recruitment target (n=20), with 72.4% retention at 6 months. All feasibility progression criteria were met. Descriptive trends showed expected post-MBS reductions in weight and BMI and improvements in blood pressure and hemoglobin A(1c), with no adverse cardiometabolic effects observed. CONCLUSIONS: TeenLyft demonstrated high feasibility, acceptability, and safety as an adjunct to adolescent MBS care. Findings support progression to a fully powered randomized trial to evaluate long-term effectiveness and sustainability. CI - (c) Sarah E Messiah, Jackson M Francis, Folefac D Atem, Matthew Sunil Mathew, Alicia Wheelington, Maral Misserian, Sitapriya Neti, Rashon Braxton, Bethany R Cartwright, Faisal G Qureshi, Sarah E Barlow, Marlyn A Alicock. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Messiah, Sarah E AU - Messiah SE AUID- ORCID: 0000-0001-6685-2175 AD - Peter O'Donnell Jr. School of Public Health, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, United States, 1 3057785309. AD - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States. AD - Child and Adolescent Population Health Program, Children's Health System of Texas, Dallas, TX, United States. AD - Children's Health System of Texas, Dallas, TX, United States. FAU - Francis, Jackson M AU - Francis JM AUID- ORCID: 0009-0003-3840-8431 AD - Child and Adolescent Population Health Program, Children's Health System of Texas, Dallas, TX, United States. FAU - Atem, Folefac D AU - Atem FD AUID- ORCID: 0000-0002-1142-7806 AD - University of Texas Health Science Center at Houston (UTHealth) School of Public Health, Dallas, TX, United States. FAU - Mathew, Matthew Sunil AU - Mathew MS AUID- ORCID: 0000-0002-7529-2832 AD - Child and Adolescent Population Health Program, Children's Health System of Texas, Dallas, TX, United States. FAU - Wheelington, Alicia AU - Wheelington A AUID- ORCID: 0000-0003-1739-8759 AD - Children's Health System of Texas, Dallas, TX, United States. AD - Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States. FAU - Misserian, Maral AU - Misserian M AUID- ORCID: 0000-0001-8369-5132 AD - School of Allied Health Professions, University of Texas Southwestern Medical Center, Dallas, TX, United States. FAU - Neti, Sitapriya AU - Neti S AUID- ORCID: 0000-0003-4445-3258 AD - Child and Adolescent Population Health Program, Children's Health System of Texas, Dallas, TX, United States. FAU - Braxton, Rashon AU - Braxton R AUID- ORCID: 0009-0006-8397-1532 AD - University of Texas Health Science Center at Houston (UTHealth) School of Public Health, Dallas, TX, United States. FAU - Cartwright, Bethany R AU - Cartwright BR AUID- ORCID: 0000-0002-1013-9298 AD - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States. AD - Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, United States. FAU - Qureshi, Faisal G AU - Qureshi FG AUID- ORCID: 0000-0002-7986-720X AD - Children's Health System of Texas, Dallas, TX, United States. AD - Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States. FAU - Barlow, Sarah E AU - Barlow SE AUID- ORCID: 0000-0002-1672-2126 AD - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States. AD - Children's Health System of Texas, Dallas, TX, United States. FAU - Alicock, Marlyn A AU - Alicock MA AUID- ORCID: 0000-0002-2114-6768 AD - University of Texas Health Science Center at Houston (UTHealth) School of Public Health, Dallas, TX, United States. LA - eng GR - R21 HD105129/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20261005 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13638075 OTO - NOTNLM OT - adolescents OT - cardiometabolic OT - lifestyle intervention OT - metabolic and bariatric surgery OT - weight loss COIS- Conflicts of Interest: FGQ is a consultant at Ethicon Industries. All other authors declare no conflicts of interest. EDAT- 2026/10/05 17:31 MHDA- 2026/10/05 17:32 PMCR- 2026/10/05 CRDT- 2026/10/05 16:33 PHST- 2025/10/31 00:00 [received] PHST- 2026/06/14 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/10/05 17:32 [medline] PHST- 2026/10/05 17:31 [pubmed] PHST- 2026/10/05 16:33 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - v9i1e86816 [pii] AID - 86816 [pii] AID - 10.2196/86816 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Oct 5;9:e86816. doi: 10.2196/86816. PMID- 42830479 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261005 IS - 1523-5378 (Electronic) IS - 1083-4389 (Linking) VI - 31 IP - 5 DP - 2026 Sep-Oct TI - Epidemiology of Helicobacter pylori and Gastric Atrophy in Rural Southwestern Uganda: The ENIGMA Uganda Study. PG - e70163 LID - 10.1111/hel.70163 [doi] AB - BACKGROUND: Characterizing the epidemiology of Helicobacter pylori (H. pylori) infection and gastric atrophy (GA) is essential for informing preventive strategies in anticipation of the rising gastric cancer burden. The International Agency for Research on Cancer has initiated global studies to characterize these epidemiological patterns using a standardized framework, including in Uganda. MATERIALS AND METHODS: This population-based study included 700 individuals aged 1-69 years, randomly selected from the General Population Cohort in rural Uganda, stratified by sex and age. Participants completed a structured questionnaire to assess risk factors related to H. pylori infection and GA, underwent anthropometric measurements, and provided blood samples. Anti-H. pylori IgG antibodies were measured using enzyme-linked immunosorbent assays (ELISA). In individuals aged >/= 40 years, plasma pepsinogen I (PG I) and pepsinogen II (PG II) concentrations were measured by ELISA to define gastric atrophy. RESULTS: The age-standardized H. pylori seroprevalence was 76%. The crude seroprevalence was 63% in children aged 1-9 years, rose to over 80% in individuals aged 10-39 years, and then declined modestly in older age groups (73% in individuals aged >/= 40). Men aged >/= 40 years had a lower H. pylori seroprevalence compared to women aged >/= 40 years (68% vs. 78%, p < 0.05). Serologically defined GA was uncommon, with an overall prevalence of 6% (17/301; 95% CI: 3%-9%) among individuals aged >/= 40 years. Obesity (aOR 6.0, 95% CI 1.6-20.9) and less than daily chili consumption (aOR 4.3, 95% CI 1.4-14.9) were associated with higher odds of GA among participants aged >/= 40 years, after adjustment for age and sex. CONCLUSIONS: In this population-based study in rural southwestern Uganda, H. pylori infection was acquired early in life and was highly prevalent, whereas serologically defined gastric atrophy remained relatively uncommon. This distinct epidemiological pattern warrants further validation and investigation. CI - (c) 2026 John Wiley & Sons Ltd. The WHO International Agency for Research on Cancer retains copyright and all other rights in the manuscript of this article as submitted for publication. FAU - Huang, Yue AU - Huang Y AUID- ORCID: 0000-0002-0864-8990 AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Knaze, Viktoria AU - Knaze V AUID- ORCID: 0000-0002-9646-2052 AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Mugisha, Joseph AU - Mugisha J AD - Uganda Research Unit, MRC/UVRI and LSHTM, Entebbe, Uganda. FAU - Navionis, Anne-Sophie AU - Navionis AS AUID- ORCID: 0009-0002-9854-1114 AD - Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. FAU - Rinaldi, Sabina AU - Rinaldi S AUID- ORCID: 0000-0002-6846-1204 AD - Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. FAU - Clifford, Gary M AU - Clifford GM AUID- ORCID: 0000-0001-7534-333X AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Park, Jin Young AU - Park JY AUID- ORCID: 0000-0003-2491-5099 AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Newton, Robert AU - Newton R AD - Uganda Research Unit, MRC/UVRI and LSHTM, Entebbe, Uganda. AD - University of York, York, UK. LA - eng GR - Centre International de Recherche sur le Cancer/ PT - Journal Article PL - England TA - Helicobacter JT - Helicobacter JID - 9605411 RN - 0 (Antibodies, Bacterial) RN - 9001-10-9 (Pepsinogen A) SB - IM MH - Humans MH - Uganda/epidemiology MH - *Helicobacter Infections/epidemiology/complications MH - Female MH - Male MH - Adult MH - Middle Aged MH - Adolescent MH - Child MH - Child, Preschool MH - *Helicobacter pylori/isolation & purification/immunology MH - Aged MH - Young Adult MH - Infant MH - Rural Population MH - Seroepidemiologic Studies MH - Antibodies, Bacterial/blood MH - *Gastritis, Atrophic/epidemiology MH - Pepsinogen A/blood MH - Risk Factors MH - Prevalence MH - Enzyme-Linked Immunosorbent Assay OTO - NOTNLM OT - Helicobacter pylori OT - gastric atrophy OT - pepsinogen OT - prevalence EDAT- 2026/10/05 05:31 MHDA- 2026/10/05 05:32 CRDT- 2026/10/05 00:33 PHST- 2026/08/12 00:00 [revised] PHST- 2026/06/16 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/05 05:32 [medline] PHST- 2026/10/05 05:31 [pubmed] PHST- 2026/10/05 00:33 [entrez] AID - 10.1111/hel.70163 [doi] PST - ppublish SO - Helicobacter. 2026 Sep-Oct;31(5):e70163. doi: 10.1111/hel.70163. PMID- 42830421 OWN - NLM STAT- Publisher LR - 20261004 IS - 1547-6510 (Electronic) IS - 1040-8347 (Linking) DP - 2026 Oct 4 TI - Analytical Strategies for Trace-Level Determination of Hormones in Infant Milk Formula: Advances, Challenges, and Future Perspectives. PG - 1-21 LID - 10.1080/10408347.2026.2736080 [doi] AB - Infant milk formula (IMF) is designed to support infants during a highly sensitive stage of development, yet its trace-level bioactive composition remains less explored than its nutritional profile. Among these minor constituents, hormones are of particular interest because they link infant nutrition with endocrine regulation, food safety, and analytical chemistry. Hormones in IMF may originate naturally from milk-derived ingredients, result from veterinary practices, or occur as hormone-like endocrine-active residues. However, their determination is challenging due to their low concentrations and the complexity of the formula matrix, which can interfere with extraction, clean-up, separation, and detection. This review critically summarizes recent advances in analytical strategies for trace-level hormone determination in IMF, focusing on sample preparation, chromatographic and mass spectrometric techniques, method validation, analytical challenges, and future perspectives. It also critically evaluates the reported analytical strategies from a White Analytical Chemistry perspective, emphasizing the balance between analytical performance, environmental sustainability, robustness, cost-effectiveness, and routine applicability. Despite progress in extraction, purification, and sensitive detection approaches, gaps remain in occurrence data, method harmonization, validation consistency, and exposure assessment. To the best of our knowledge, this is the first review dedicated specifically to hormones analysis in IMF. FAU - S El-Tahlawy, Ahmed AU - S El-Tahlawy A AUID- ORCID: 0000-0002-4506-0168 AD - Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand. FAU - Alahmad, Waleed AU - Alahmad W AUID- ORCID: 0000-0003-1379-8755 AD - Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand. LA - eng PT - Journal Article PT - Review DEP - 20261004 PL - United States TA - Crit Rev Anal Chem JT - Critical reviews in analytical chemistry JID - 9004784 SB - IM OTO - NOTNLM OT - Analytical methods OT - hormones OT - infant formula OT - sample preparation EDAT- 2026/10/05 05:31 MHDA- 2026/10/05 05:31 CRDT- 2026/10/04 23:59 PHST- 2026/10/05 05:31 [medline] PHST- 2026/10/05 05:31 [pubmed] PHST- 2026/10/04 23:59 [entrez] AID - 10.1080/10408347.2026.2736080 [doi] PST - aheadofprint SO - Crit Rev Anal Chem. 2026 Oct 4:1-21. doi: 10.1080/10408347.2026.2736080. PMID- 42830064 OWN - NLM STAT- MEDLINE DCOM- 20261004 LR - 20261004 IS - 1512-0112 (Print) IS - 1512-0112 (Linking) IP - 376-377 DP - 2026 Jul-Aug TI - ACE I/D AND NOS3 G894T POLYMORPHISMS AND CARDIOVASCULAR ADAPTATION PROFILES IN ADOLESCENT FOOTBALL PLAYERS. PG - 281-288 AB - AIM: To assess the associations of ACE I/D (rs4646994) and NOS3 G894T (rs1799983) polymorphisms with cardiovascular adaptation profiles, autonomic regulation, exercise tolerance and responsiveness to individualized training-load correction in adolescent football players. MATERIALS AND METHODS: This controlled comparative study with an observational pre-post follow-up component included 228 male adolescents aged 13-17 years: 168 football players with at least two years of regular training and 60 non-athlete peers. The examination included anthropometry, body composition assessment, resting and exercise electrocardiography, echocardiography, short-term heart rate variability (HRV) analysis, submaximal bicycle ergometry with PWC170 and estimated VO2max, heart-rate recovery (HRR), and genotyping of ACE I/D and NOS3 G894T polymorphisms. The 3-month individualized training-load correction was analyzed as a non-randomized observational component; therefore, its results were interpreted as post-correction dynamics rather than as definitive evidence of causal efficacy. RESULTS: Football players had a lower resting heart rate than controls (58.6+/-6.8 vs 72.4+/-7.5 beats/min; p<0.001), higher PWC170 (196+/-32.6 vs 142+/-28.4 W; p<0.001), higher relative PWC170 (3.42+/-0.52 vs 2.40+/-0.46 W/kg; p<0.001), higher estimated VO2max (54.0+/-4.8 vs 42.5+/-5.2 ml/kg/min; p<0.001) and faster HRR1 (43.6+/-11.3 vs 25.3+/-10.4 beats/min; p<0.001). ACE and NOS3 genotype distributions were comparable between football players and controls. Within the athletic cohort, ACE DD and, to a lesser extent, NOS3 T-allele carriage were associated with lower SDNN, RMSSD and pNN50, higher LF/HF and less favorable diastolic indices. After three months of individualized training-load correction, positive HRV and diastolic dynamics were observed mainly in favorable and intermediate genetic profiles, whereas the unfavorable profile showed limited changes. CONCLUSION: ACE I/D and NOS3 G894T polymorphisms should not be interpreted as markers of football participation or selection. They may be considered exploratory modifiers of autonomic reserve, diastolic adaptation and response to individualized training-load monitoring. Integration of genotyping with ECG, echocardiography, HRV, HRR and PWC170 appears promising for personalized monitoring in adolescent football players but requires further external validation. The results of the dynamic stage should be interpreted as observational, since the training-load correction was not randomized. FAU - Ruziyeva, A AU - Ruziyeva A AD - 1Department of Medical Rehabilitation, Sports Medicine and Traditional Medicine of the Samarkand State Medical University, Uzbekistan. FAU - Khamidov, O AU - Khamidov O AD - 2Rehabilitology and Sports Medicine Research Institute of the Samarkand State Medical University, Uzbekistan. FAU - Murodqosimov, S AU - Murodqosimov S AD - 3Department of Biology, Samarkand State Pedagogical Institute, Uzbekistan. FAU - Doniyorov, B AU - Doniyorov B AD - 4Faculty of Medicine, Abdulla Qodiriy Jizzakh State Pedagogical University, Uzbekistan. FAU - Khalimova, F AU - Khalimova F AD - 5Department of Normal and Pathological Physiology, Medical-Social Institute of Tajikistan, Dushanbe, Tajikistan. FAU - Marwan, I AU - Marwan I AD - 6Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates. LA - eng PT - Journal Article PL - Georgia (Republic) TA - Georgian Med News JT - Georgian medical news JID - 101218222 RN - EC 3.4.15.1 (Peptidyl-Dipeptidase A) RN - EC 1.14.13.39 (Nitric Oxide Synthase Type III) RN - EC 1.14.13.39 (NOS3 protein, human) RN - EC 3.4.15.1 (ACE protein, human) SB - IM MH - Humans MH - Adolescent MH - Male MH - *Peptidyl-Dipeptidase A/genetics MH - *Nitric Oxide Synthase Type III/genetics MH - Heart Rate/genetics/physiology MH - *Adaptation, Physiological/genetics MH - Polymorphism, Single Nucleotide MH - Athletes MH - Exercise Tolerance/genetics MH - Soccer MH - Genotype MH - Polymorphism, Genetic EDAT- 2026/10/04 23:29 MHDA- 2026/10/04 23:30 CRDT- 2026/10/04 18:43 PHST- 2026/10/04 23:30 [medline] PHST- 2026/10/04 23:29 [pubmed] PHST- 2026/10/04 18:43 [entrez] PST - ppublish SO - Georgian Med News. 2026 Jul-Aug;(376-377):281-288. PMID- 42829788 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261004 LR - 20261005 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 15 DP - 2026 TI - Design and implementation of a pediatric failure to thrive registry system in Iran. PG - 366 LID - 10.4103/jehp.jehp_852_25 [doi] LID - 366 AB - BACKGROUND: Failure to thrive (FTT) refers to inadequate growth caused by an inability to acquire or use enough calories for growth. It refers to a failure to develop over time, which can lead to more serious problems in adulthood if left untreated. FTT is a significant global health concern, particularly in developing countries like Iran. Effective FTT management necessitates timely, inclusive, and precise data on children's FTT status. A pediatric FTT registry system is a useful tool for gathering and managing data on children with FTT. This study proposes a pediatric FTT registry system for Iran. MATERIALS AND METHODS: A developmental-applied study was conducted in three phases during 2024. The first phase involved defining the features of a pediatric FTT registry system through interviews with experts. The second phase entailed expert validation using the Delphi method. In the third phase, the software was designed based on a conceptual model using the Hypertext Preprocessor programming language and the Laravel framework. PostgreSQL was employed as the database management system. Moreover, Nielsen's Ten Usability Heuristics was used to evaluate the software's usability from the users' perspectives. RESULTS: Experts validated the features of the pediatric FTT registry system, resulting in a framework that included eight headings, 24 sub-headings, and 117 data elements. The usability assessment of the software revealed that the highest number of issues concerned the "error prevention" indicator, whereas the "aesthetic and minimalist design" indicator presented the fewest problems and was assumed flawless. CONCLUSION: A pediatric FFT registry system contributes significantly to service planning, management, disease surveillance, and research. Accordingly, future research is recommended to investigate the feasibility of implementing the pediatric FFT registry system in Iran. CI - Copyright: (c) 2026 Journal of Education and Health Promotion. FAU - Khademi, Sahar AU - Khademi S AD - Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. FAU - Langarizadeh, Mostafa AU - Langarizadeh M AD - Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. FAU - Sheikhtaheri, Abbas AU - Sheikhtaheri A AD - Health Management and Economics Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20260831 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC13633805 OTO - NOTNLM OT - Failure to thrive OT - failure to thrive registry OT - low weight OT - registry OT - registry system OT - stunting COIS- There are no conflicts of interest. EDAT- 2026/10/04 05:36 MHDA- 2026/10/04 05:37 PMCR- 2026/08/31 CRDT- 2026/10/04 04:15 PHST- 2025/05/08 00:00 [received] PHST- 2025/07/29 00:00 [accepted] PHST- 2026/10/04 05:37 [medline] PHST- 2026/10/04 05:36 [pubmed] PHST- 2026/10/04 04:15 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - JEHP-15-366 [pii] AID - 10.4103/jehp.jehp_852_25 [doi] PST - epublish SO - J Educ Health Promot. 2026 Aug 31;15:366. doi: 10.4103/jehp.jehp_852_25. eCollection 2026. PMID- 42829644 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261004 LR - 20261005 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 15 DP - 2026 TI - The relationship between health literacy and the adoption of preventive behaviors against high blood pressure among villagers: A cross-sectional study in Iran. PG - 345 LID - 10.4103/jehp.jehp_664_25 [doi] LID - 345 AB - BACKGROUND: Considering the limited number of studies on health literacy among the rural population, the necessity of measuring the level of health literacy, and the increasing number of patients with hypertension, the present study aimed to determine the relationship between health literacy and the adoption of preventive behaviors in high blood pressure among the villagers. MATERIALS AND METHODS: In a descriptive-analytical cross-sectional study, 300 villagers living in Qayenat were selected by multi-stage random sampling in 2024. The data were obtained by demographic and background characteristics and the health literacy assessment questionnaire (HELIA) as well as a valid and reliable questionnaire to measure the adoption of preventive behaviors against hypertension. The data were analyzed using SPSS ver 22. (IBM Coporation, Armonk, NY) and descriptive statistics and logistic regression. RESULTS: The mean and standard deviation of adoption of preventive behaviors against hypertension and health literacy were 15.188 +/- 1.215 and 61.07 +/- 18.206, respectively, and both were at an unfavorable level. Health literacy, the number of children, the amount of physical activity per week, and the history of having high blood pressure were effective factors in adopting preventive behaviors against high blood pressure. CONCLUSION: The adoption of preventive behaviors against hypertension was lower among villagers with lower health literacy, having more children, less physical activity per week, and those who had no history of hypertension. Therefore, community health policymakers must design educational interventions in health literacy and hypertension prevention to help improve these patients' health. CI - Copyright: (c) 2026 Journal of Education and Health Promotion. FAU - Panahi, Rahman AU - Panahi R AD - Health Metrics Research Center, Institute for Health Sciences Research, ACECR, Tehran, Iran. AD - Assistant Professor, Department of Psychology, School of Humanities Sciences, Payam Noor University, Tehran, Iran. FAU - Shokhmgar, Zahra AU - Shokhmgar Z AD - Faculty Member of Payam Noor University, Tehran, Iran. FAU - Tavakoli, Masoumeh AU - Tavakoli M AD - Health Metrics and Evaluation Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. FAU - Yari, Fatemeh AU - Yari F AD - Health Metrics and Evaluation Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. FAU - Gholipour Saftouk, Mohadeseh AU - Gholipour Saftouk M AD - Health Metrics and Evaluation Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. FAU - Vafainasab, Aghileh AU - Vafainasab A AD - Health Metrics and Evaluation Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. FAU - Amjadian, Mohiadin AU - Amjadian M AD - Clinical Psychology Department, Metrics and Evaluation Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. LA - eng PT - Journal Article DEP - 20260831 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC13633783 OTO - NOTNLM OT - Health literacy OT - high blood pressure OT - preventive behaviors OT - villagers COIS- There are no conflicts of interest. EDAT- 2026/10/04 05:36 MHDA- 2026/10/04 05:37 PMCR- 2026/08/31 CRDT- 2026/10/04 04:02 PHST- 2025/04/08 00:00 [received] PHST- 2025/07/01 00:00 [accepted] PHST- 2026/10/04 05:37 [medline] PHST- 2026/10/04 05:36 [pubmed] PHST- 2026/10/04 04:02 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - JEHP-15-345 [pii] AID - 10.4103/jehp.jehp_664_25 [doi] PST - epublish SO - J Educ Health Promot. 2026 Aug 31;15:345. doi: 10.4103/jehp.jehp_664_25. eCollection 2026. PMID- 42829327 OWN - NLM STAT- Publisher LR - 20261003 IS - 1751-8431 (Electronic) IS - 1751-8423 (Linking) DP - 2026 Oct 3 TI - Clinical Relevance of the Eating and Drinking Ability Classification System in Young Children with Cerebral Palsy: Associations with Child and Family Outcomes Relevant to Rehabilitation. PG - 1-9 LID - 10.1080/17518423.2026.2738684 [doi] AB - BACKGROUND: The Eating and Drinking Ability Classification System (EDACS) is a validated functional classification system for assessing feeding ability in individuals with cerebral palsy (CP). Its clinical relevance in relation to broader child and family outcomes has received limited attention, particularly in young children. This study evaluated associations between EDACS and motor function, communication ability, nutritional status, behavioral profile and caregiver quality of life in young children with CP. METHODS: This cross-sectional study included 100 children aged 18-60 months with CP attending a tertiary Child Development Center in North India. Of these, 49 (49%) were aged 18-35 months and 51 (51%) were aged 36-60 months; 49 (49%) were classified as GMFCS Levels IV-V. Feeding ability was classified using age-appropriate EDACS descriptors. Gross motor function and communication were assessed using GMFCS and CFCS, respectively. Nutritional status was assessed using weight-for-length/height Z scores, mid-upper arm circumference and clinical pallor. Behavioral problems and caregiver quality of life were evaluated using the Child Behavior Checklist and WHOQOL-BREF, respectively. Associations were assessed using Kruskal-Wallis and Fisher's exact tests, Spearman's rank correlation, cumulative ordinal logistic regression and linear regression. RESULTS: Increasing EDACS level was associated with poorer nutritional status, including lower weight-for-length/height Z scores, reduced mid-upper arm circumference and higher prevalence of clinical pallor (all p /= 25 kg/m(2) recruited from central Arkansas. The participants will be randomized to a standard of care group receiving standardized lactation support (N = 60); a prenatal intervention group receiving standardized lactation support + antenatal breast milk expression (ABME) between 37 weeks of gestation until birth (N = 60); or a postnatal intervention group receiving standardized lactation support + dietary meal plan designed to align with the Dietary Guidelines for Americans from 2 weeks to 6 months postpartum (N = 60). Study assessments will include repeated measures of maternal and infant anthropometrics, body composition, dietary intake, and archiving of biospecimens (blood, human milk, stool, and urine) during infancy and until 6 months postpartum. The primary outcomes are breastfeeding outcomes (initiation, duration, exclusivity) and human milk composition (macronutrients, energy, and bioactive components). Questionnaires will assess maternal demographics and socioeconomic status, breastfeeding self-efficacy, maternal depression, stress, and quality of life as well as infant feeding intention, and medical lactation history. DISCUSSION: This randomized control trial will generate novel evidence on the safety, feasibility, and effectiveness of ABME and provision of a healthy postnatal meal plan in a population at elevated risk for breastfeeding challenges. By evaluating clinical and nutritional strategies, this study will advance the understanding of how maternal behavior and physiology influence breastfeeding outcomes, human milk composition and early life programming of infant growth and development. Findings will also address critical gaps identified by the Dietary Guidelines Advisory Committee by guiding nutritional recommendations for women with excess weight. The results will inform future strategies targeting short and long-term maternal-infant health outcomes. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT00616395, identifier NCT00616395. CI - Copyright (c) 2026 da Cruz, Fiecke, Fuenmayor, Beckett, Morris, Kay, Massey-Swindle, Sobik and Andres. FAU - da Cruz, Larissa Leandro AU - da Cruz LL AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Fiecke, Chelsey AU - Fiecke C AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Fuenmayor, Anni AU - Fuenmayor A AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. FAU - Beckett, Emily AU - Beckett E AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. AD - Arkansas Children's Hospital, Southwest Little Rock Community Clinic, Little Rock, AR, United States. FAU - Morris, Andrew AU - Morris A AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Kay, Colin D AU - Kay CD AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Massey-Swindle, Taren AU - Massey-Swindle T AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Sobik, Sarah AU - Sobik S AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Andres, Aline AU - Andres A AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. LA - eng SI - ClinicalTrials.gov/NCT00616395 PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13630693 OTO - NOTNLM OT - antenatal breastmilk expression OT - breastfeeding OT - colostrum OT - dietary intervention OT - human milk OT - lactation support OT - obesity OT - pregnancy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:50 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:50 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fnut.2026.1854997 [doi] PST - epublish SO - Front Nutr. 2026 Sep 18;13:1854997. doi: 10.3389/fnut.2026.1854997. eCollection 2026. PMID- 42827757 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261003 LR - 20261005 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Fifteen-minute recess freestyle rope skipping enhances classroom attention in junior high school students in the context of healthy school development: mechanisms and implications. PG - 1906224 LID - 10.3389/fpsyg.2026.1906224 [doi] LID - 1906224 AB - In the context of healthy school development and the policy mandating 15-min recess physical activity for middle school students, this study employed a longitudinal quasi-experimental design to investigate the effects of 15-min recess freestyle rope skipping on middle school students' classroom attention and emotional indicators. Based on grade level and activity format (individual practice vs. group cooperation), a total of 160 students, 80 boys and 80 girls, aged 13.9 to 14.5 years, from grades 8 and 9 at a middle school in Shijiazhuang were selected and divided into four groups. A 16-week intervention involving individual vs. group freestyle rope skipping for 15 min per session was conducted. Students' recess immediate emotions, classroom academic emotions, and classroom attention were measured using validated self-report scales, specifically the Exercise-Induced Mood Scale, the Classroom Academic Emotion Scale, and the Classroom Attention Scale, at three time points (pre-intervention, mid-intervention, and post-intervention). Data were analyzed using repeated-measures ANOVA, correlation analysis, and mediation analysis. The results indicated that classroom attention significantly increased from 65.54 (pre-intervention) to 74.68 (post-intervention) across all groups. Classroom academic emotions and recess immediate emotions also exhibited significant changes over time, with significant time x group interaction effects, suggesting that the trajectories of change differed by grade level and activity format. Correlation analysis revealed that improvements in recess immediate emotions and classroom academic emotions were significantly positively correlated with increases in classroom attention, with the strongest correlation found between classroom academic emotions and classroom attention changes (r = 0.450, p < 0.001). Mediation analysis showed that classroom academic emotions significantly mediated the relationship between activity format and changes in classroom attention (indirect effect = 3.098, 95% CI [1.179, 5.525]), whereas the chain mediation pathway (recess immediate emotions --> classroom academic emotions --> classroom attention) was not significant. This study provides evidence that 15-min recess freestyle rope skipping is associated with improvements in middle school students' classroom attention and improve their emotional states, with the intervention effects moderated by grade level and activity format. This study provides empirical evidence for the fields of physical activity, emotion, and attention, and offers practical guidance for optimizing recess physical activities and promoting healthy school development in secondary schools. CI - Copyright (c) 2026 Li, Chen, Cen and Liu. FAU - Li, Jianmin AU - Li J AD - College of Physical Education, Hefei University of Technology, Hefei, China. FAU - Chen, Xiaoting AU - Chen X AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Cen, Wei AU - Cen W AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Liu, Chao AU - Liu C AD - College of Physical Education, Yangzhou University, Yangzhou, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13630699 OTO - NOTNLM OT - 15-min recess OT - classroom academic emotions OT - classroom attention OT - freestyle rope skipping OT - healthy school development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:49 PHST- 2026/06/11 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:49 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1906224 [doi] PST - epublish SO - Front Psychol. 2026 Sep 18;17:1906224. doi: 10.3389/fpsyg.2026.1906224. eCollection 2026. PMID- 42827730 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261003 LR - 20261005 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Predicting multiple mental health outcomes in adolescents using explainable machine learning models. PG - 1923390 LID - 10.3389/fpsyt.2026.1923390 [doi] LID - 1923390 AB - INTRODUCTION: Adolescent mental health problems, including depression, anxiety, and stress, are an increasing public health concern, yet the factors associated with different mental health outcomes may vary across domains. This study investigated shared and outcome-specific predictive features of depression, anxiety, perceived stress, and psychological well-being using explainable machine learning models. METHODS: A cross-sectional study was conducted among 1,088 adolescents aged 13-18 years recruited from secondary schools in Wuhan, China, using multistage cluster sampling. Participants completed validated measures of emotional dysregulation, loneliness, social media addiction, self-esteem, sleep quality, academic stress, family support, physical activity, and mental health outcomes. Four algorithms-linear regression, support vector regression, Random Forest, and XGBoost-were trained using an 80/20 train-test split with five-fold cross-validation, and model performance was evaluated using test-set R(2), RMSE, and MAE. SHapley Additive exPlanations (SHAP) were used to examine feature contributions. To minimize target leakage, outcome-specific feature sets were used, with PSQI and RSES excluded from the depression model because of direct or substantial conceptual overlap with PHQ-9 content, and PSQI excluded from the well-being model because of overlap with WHO-5 content. RESULTS: XGBoost showed the strongest out-of-sample predictive performance across all four outcomes, explaining 49% of the variance in depression (R(2) = 0.49, 95% CI: 0.44-0.53; RMSE = 3.52; MAE = 2.81), 55% in anxiety (R(2) = 0.55, 95% CI: 0.50-0.59; RMSE = 3.04; MAE = 2.47), 60% in perceived stress (R(2) = 0.60, 95% CI: 0.56-0.64; RMSE = 3.71; MAE = 2.87), and 50% in psychological well-being (R(2) = 0.50, 95% CI: 0.45-0.54; RMSE = 3.38; MAE = 2.68). DISCUSSION: Emotional dysregulation and loneliness were consistently among the most influential features, while academic stress, family support, social media addiction, self-esteem, and sleep quality showed outcome-specific contributions. SHAP rankings for the depression model were stable across five-fold cross-validation, with emotional dysregulation and loneliness consistently occupying the highest ranks. CI - Copyright (c) 2026 Dong, Meng, Wang, Yan and Liu. FAU - Dong, Xiaojie AU - Dong X AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Meng, Jing AU - Meng J AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Wang, Peng AU - Wang P AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Yan, Chuandong AU - Yan C AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Liu, Xiaobo AU - Liu X AD - Department of Medical Administration, Wuhan Mental Health Center, Wuhan, Hubei, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13631644 OTO - NOTNLM OT - adolescent OT - emotional dysregulation OT - loneliness OT - machine learning OT - mental health OT - predictive modeling COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:43 PHST- 2026/06/29 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:43 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1923390 [doi] PST - epublish SO - Front Psychiatry. 2026 Sep 18;17:1923390. doi: 10.3389/fpsyt.2026.1923390. eCollection 2026. PMID- 42827615 OWN - NLM STAT- MEDLINE DCOM- 20261003 LR - 20261006 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - A novel method based on ultrasound radiomics for predicting attainment of near-adult height in adolescents. PG - 1925196 LID - 10.3389/fendo.2026.1925196 [doi] LID - 1925196 AB - OBJECTIVE: This study aimed to develop and validate a novel ultrasound radiomics model for predicting the attainment of near-adult height (NAH) in adolescents. METHODS: This dual-center prospective cohort study enrolled 192 adolescents aged 11.0-18.0 years. Standardized ultrasound examinations of the ulnar growth plate region were performed, and 475 radiomic features were extracted. Feature selection was conducted using Least Absolute Shrinkage and Selection Operator (LASSO) algorithm with 5-fold cross-validation. Seven machine learning algorithms were compared to develop predictive models. Three models were constructed: clinical (sex and bone age), radiomics (Rad-score), and combined (sex, bone age, and Rad-score). Model performance was evaluated using area under the receiver operating characteristic curve, accuracy, sensitivity, specificity, calibration curves, and decision curve analysis. RESULTS: Three stable radiomic features were selected with selection frequency >/=80%: wavelet-LH_glcm_Imc2, wavelet-LL_ngtdm_Busyness, and wavelet-HL_firstorder_Energy. The combined model demonstrated superior performance, achieving AUCs of 0.981 (95% CI: 0.948-1.000) in the validation set, with sensitivity of 90% and specificity of 100%. Multivariate analysis identified independent positive predictors including Rad-score (OR = 3.28, P = 0.013) and bone age (OR = 2.65, P < 0.001). And male sex was a significant negative predictor (OR = 0.15, P = 0.005). CONCLUSION: The combined ultrasound radiomics machine learning model achieved excellent predictive performance for NAH attainment in adolescents. The non-ionizing ultrasound approach enables repeated dynamic monitoring, and the derived nomogram facilitates individualized risk stratification in routine pediatric practice. CI - Copyright (c) 2026 Zhang, Zhao, Sun, Zhang, Yang, Pan, Chen, Li and Yang. FAU - Zhang, Yixuan AU - Zhang Y AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zhao, Zeqing AU - Zhao Z AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Sun, Yuxin AU - Sun Y AD - Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zhang, Li AU - Zhang L AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Yang, Yamei AU - Yang Y AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Pan, Hui AU - Pan H AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Chen, Shi AU - Chen S AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Li, Jianchu AU - Li J AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Yang, Xiao AU - Yang X AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. AD - Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, Fujian, China. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260918 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Body Height/physiology MH - *Growth Plate/diagnostic imaging MH - Machine Learning MH - Prospective Studies MH - *Radiomics MH - Ultrasonography/methods PMC - PMC13630604 OTO - NOTNLM OT - adolescent growth assessment OT - machine learning OT - near-adult height OT - predictive model OT - ultrasound radiomics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:29 PHST- 2026/07/01 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:29 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fendo.2026.1925196 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 18;17:1925196. doi: 10.3389/fendo.2026.1925196. eCollection 2026. PMID- 42827605 OWN - NLM STAT- MEDLINE DCOM- 20261003 LR - 20261005 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Near-final adult height after GnRHa plus growth hormone in central precocious puberty: a single-center cohort study and predicted adult height validation audit. PG - 1885575 LID - 10.3389/fendo.2026.1885575 [doi] LID - 1885575 AB - BACKGROUND: Whether adjunctive recombinant human growth hormone (rhGH) improves near-final adult height (NFAH) during gonadotropin-releasing hormone analog (GnRHa) therapy for central precocious puberty (CPP) remains uncertain, and predicted adult height (PAH) may reflect treatment selection and prognosis. METHODS: We analyzed a single-center retrospective cohort of 235 children with CPP who initiated GnRHa between January 2018 and December 2020. The primary endpoint was chart-recorded NFAH in the female-only maturity-ascertained cohort (n = 91); the criterion-confirmed all-sex set included 94 patients. The primary adjusted model (M2) included treatment, baseline age, body mass index (BMI), IGF-1, BA-CA, and baseline height; baseline bone age was not entered separately because bone age = chronological age + BA-CA. Missing baseline covariates were handled using 20 imputations by chained equations. Height gain and change in height standard deviation score (SDS) from baseline to 24 months were secondary outcomes. Results: Mean NFAH was 160.17 cm with GnRHa alone and 161.87 cm with GnRHa + rhGH. The adjusted M2 association was +2.26 cm (95% CI 0.12 to 4.40); the chart-PAH-conditioned M3 estimate was +0.58 cm (-1.60 to 2.75) and was treated as diagnostic. At 24 months, M2 estimates were +3.23 cm (2.00 to 4.46) for height gain, +3.24 cm (2.03 to 4.46) in analysis of covariance (ANCOVA) of attained height, and +0.46 SDS (0.27 to 0.66). In the criterion-confirmed female bone-age cohort, M2 estimates were +0.00 years (-0.27 to 0.27) for bone age at 24 months and -0.14 years (-0.30 to 0.03) for bone-age progression. CONCLUSIONS: Adjunctive rhGH was associated with greater growth over 24 months and a positive, imprecisely estimated NFAH difference. Because this was an observational study, ascertainment criteria were heterogeneous, and the NFAH estimate was sensitive to PAH adjustment and criterion restriction, the adult-height finding should be interpreted cautiously. CI - Copyright (c) 2026 Jin, Wang, Qian, Zhang, Liu and Yang. FAU - Jin, Peili AU - Jin P AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Wang, Duomei AU - Wang D AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Qian, Minyan AU - Qian M AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Zhang, Huimin AU - Zhang H AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Liu, Chang AU - Liu C AD - Medical Affairs Department, GeneScience Pharmaceuticals, Changchun, Jilin, China. FAU - Yang, Rongwei AU - Yang R AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 33515-09-2 (Gonadotropin-Releasing Hormone) RN - 12629-01-5 (Human Growth Hormone) RN - 0 (Puberty Inhibitors) SB - IM MH - Humans MH - *Puberty, Precocious/drug therapy MH - Female MH - *Body Height/drug effects MH - *Gonadotropin-Releasing Hormone/analogs & derivatives/therapeutic use/administration & dosage MH - Retrospective Studies MH - *Human Growth Hormone/administration & dosage/therapeutic use MH - Puberty Inhibitors MH - Child MH - Puberty Suppression MH - Male MH - Cohort Studies MH - Prognosis MH - Adult PMC - PMC13630612 OTO - NOTNLM OT - central precocious puberty OT - confounding by indication OT - gonadotropin-releasing hormone analog OT - growth hormone OT - near-final adult height OT - observational methods OT - predicted adult height OT - validation audit COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:28 PHST- 2026/05/19 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:28 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fendo.2026.1885575 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 18;17:1885575. doi: 10.3389/fendo.2026.1885575. eCollection 2026. PMID- 42827553 OWN - NLM STAT- MEDLINE DCOM- 20261003 LR - 20261005 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Latent profile analysis of dietary behavior in pediatric patients with short stature: a single-center study in China. PG - 1919578 LID - 10.3389/fpubh.2026.1919578 [doi] LID - 1919578 AB - OBJECTIVE: To identify potential subtypes of dietary behavior in pediatric patients with short stature using latent profile analysis (LPA) and to explore the factors associated with each latent profile. METHODS: A convenience sample of 308 short-statured pediatric patients was recruited from the outpatient department of Sichuan University of West China Second Hospital from July 2025 to March 2026. Participants completed questionnaires, including a general information questionnaire, the Children's Dietary Behavior Questionnaire and the Children's Depression Inventory. LPA was used to identify the optimal number of subgroups (profiles), and binary logistic regression analysis was used to explore variables associated with profile membership. RESULTS: A total of 308 valid questionnaires were collected, yielding an effective response rate of 94.77%. This study employed LPA and identified two distinct eating patterns among pediatric patients with short stature: healthy-adaptive eating (47.73%, n = 147) and emotion-inhibited eating (52.27%, n = 161). Binary logistic regression analysis revealed that age (OR = 0.728, p < 0.001), Height SDS (OR = 0.738, p = 0.030), and lack of pleasure (OR = 1.239, p < 0.001) were independent influencing factors of emotion-inhibited eating. CONCLUSION: This study revealed two distinct subtypes of dietary behaviors among pediatric patients with short stature. A lack of pleasure was an independent risk factor for emotion-inhibited eating. Healthcare professionals should pay particular attention to children's emotional states and develop targeted interventions to address maladaptive eating patterns in this population. CI - Copyright (c) 2026 Lin and Yang. FAU - Lin, Meng AU - Lin M AD - Department of Pediatric Genetics, Metabolism and Endocrinology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, Sichuan, China. FAU - Yang, Xin AU - Yang X AD - Department of Pediatric Genetics, Metabolism and Endocrinology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, Sichuan, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Male MH - China MH - Child MH - *Feeding Behavior/psychology MH - *Body Height MH - Surveys and Questionnaires MH - Adolescent MH - Cross-Sectional Studies MH - *Diet PMC - PMC13631090 OTO - NOTNLM OT - cross-section study OT - dietary behavior OT - latent profile OT - pediatric patients OT - short stature COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:17 PHST- 2026/06/25 00:00 [received] PHST- 2026/08/29 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:17 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1919578 [doi] PST - epublish SO - Front Public Health. 2026 Sep 18;14:1919578. doi: 10.3389/fpubh.2026.1919578. eCollection 2026. PMID- 42827228 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261005 IS - 1399-3038 (Electronic) IS - 0905-6157 (Print) IS - 0905-6157 (Linking) VI - 37 IP - 10 DP - 2026 Oct TI - Validation and reliability of the Italian versions of the Food Allergy Quality of Life -Parental Burden (FAQL-PB) and -Parent Form 10 (FAQLQ-PF10) Questionnaires. PG - e70510 LID - 10.1111/pai.70510 [doi] LID - e70510 AB - BACKGROUND: Food allergy (FA) may substantially impair quality of life (QoL) in affected children and their families. Reliable and culturally adapted tools are needed to assess this burden. We aimed to translate, culturally adapt, and validate the Italian versions of the Food Allergy Quality of Life Questionnaire Parent Form 10 (FAQLQ-PF10) and the Food Allergy Quality of Life Parental Burden Questionnaire (FAQL-PB). METHODS: Following World Health Organization recommendations, the questionnaires underwent forward-backward translation and psychometric validation. Internal consistency, test-retest reliability, convergent validity, and discriminant validity were assessed in caregivers of children with FA (n = 128) and without FA (n = 52). RESULTS: Both questionnaires showed high internal consistency (Cronbach's alpha = 0.87 for FAQLQ-PF10 and 0.95 for FAQL-PB) and excellent test-retest reliability (Intraclass Correlation Coefficients 0.95 and 0.87, respectively). Moderate correlations with the Food Allergy Independent Measure (FAIM) supported convergent validity, whereas weak correlations with generic QoL and psychological distress measures confirmed disease specificity. FAQLQ-PF10 and FAQL-PB scores were significantly higher in the FA group than in controls (all p < .0001), supporting discriminant validity. Key clinical predictors of worse QoL included history of anaphylaxis, allergic comorbidities, and previous emergency department visits for FA. Parents of children with milk or egg allergy were a high-risk subgroup for impaired QoL, whereas increasing child age, longer elimination diet duration, and multiple affected siblings were associated with worse child QoL. CONCLUSIONS: The Italian versions of the FAQLQ-PF10 and FAQL-PB are valid, reliable, and disease-specific instruments for assessing FA-related QoL. Their use may facilitate routine QoL assessment and support patient-centered management of pediatric FA. CI - (c) 2026 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Comberiati, Pasquale AU - Comberiati P AUID- ORCID: 0000-0001-5209-9733 AD - Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy. FAU - Barni, Simona AU - Barni S AUID- ORCID: 0000-0001-5598-2740 AD - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy. FAU - Miccoli, Mario AU - Miccoli M AUID- ORCID: 0000-0002-8632-6145 AD - Department of Human and Social Sciences, Universita Mercatorum, Rome, Italy. FAU - DunnGalvin, Audrey AU - DunnGalvin A AUID- ORCID: 0000-0002-1540-3959 AD - School of Applied Psychology, University College Cork, Cork, Ireland. FAU - Mori, Francesca AU - Mori F AD - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy. FAU - Sarti, Lucrezia AU - Sarti L AUID- ORCID: 0000-0001-8055-3788 AD - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy. FAU - Poli, Andrea AU - Poli A AUID- ORCID: 0000-0001-7163-9627 AD - Department of Human and Social Sciences, Universita Mercatorum, Rome, Italy. FAU - Munblit, Daniel AU - Munblit D AUID- ORCID: 0000-0001-9652-6856 AD - Inflammation, Repair and Development Section, NHLI, Imperial College London, London, UK. FAU - D'Auria, Enza AU - D'Auria E AUID- ORCID: 0000-0003-2750-5810 AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Allergy Unit, Department of Pediatrics, Buzzi Children's Hospital, Milan, Italy. FAU - Fleischer, David AU - Fleischer D AD - Department of Pediatrics, Section of Allergy/Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Peroni, Diego G AU - Peroni DG AUID- ORCID: 0000-0002-0234-1373 AD - Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy. FAU - Greenhawt, Mattew AU - Greenhawt M AUID- ORCID: 0000-0002-2365-9372 AD - Aquestive Therapeutics, Inc, Warren, New Jersey, USA. LA - eng PT - Journal Article PT - Validation Study PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 SB - IM MH - Humans MH - *Quality of Life MH - *Food Hypersensitivity/psychology/epidemiology/diagnosis MH - Male MH - Female MH - Surveys and Questionnaires MH - Italy MH - Child MH - Reproducibility of Results MH - *Parents/psychology MH - Child, Preschool MH - Psychometrics MH - Adolescent MH - Adult MH - Cost of Illness MH - Caregivers/psychology PMC - PMC13633388 OTO - NOTNLM OT - FAQLQ-PF10 OT - FAQL-PB OT - caregivers OT - children OT - food allergy OT - quality of life OT - questionnaires COIS- Simona Barni reports personal fees from Nutricia, Sanofi, and Firma. David Fleischer has received grant support from Aquestive, ARS Pharmaceuticals, DBV Technologies, N-Fold; receives royalties from UpToDate; serves as a consultant to Aquestive, ARS Pharmaceuticals, DBV Technologies, Genentech, Nasus Pharma; and has stock options in Nasus Pharma and Grow Happy. Matt Greenhawt is the chief medical officer for Aquestive Therapeutics, Inc. He is a speaker for Genentech. He is a former consultant to Aquestive; speaker for ARS; advisory board member for Aquestive, DBV, Novartis, Nutricia, Genentech, ALK, Prota; former senior associate editor for Annals of Allergy, Asthma, and Immunology; served as chief medical officer for the Asthma and Allergy Foundation of America; serves as a member of the Brighton Collaboration Criteria Vaccine Anaphylaxis 2.0 working group. His work on this manuscript occurred while at Children's Hospital Colorado, but critical manuscript review and approval occurred at his current employer. His views on this manuscript are his own and not necessarily reflective of Aquestive Therapeutics, Inc. The rest of the authors declare that they have no relevant conflicts of interest. EDAT- 2026/10/03 05:33 MHDA- 2026/10/03 05:34 PMCR- 2026/10/03 CRDT- 2026/10/02 23:22 PHST- 2026/08/26 00:00 [revised] PHST- 2026/06/09 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/03 05:34 [medline] PHST- 2026/10/03 05:33 [pubmed] PHST- 2026/10/02 23:22 [entrez] PHST- 2026/10/03 00:00 [pmc-release] AID - PAI70510 [pii] AID - 10.1111/pai.70510 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 Oct;37(10):e70510. doi: 10.1111/pai.70510. PMID- 42826378 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261019 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 2 TI - Development and Validation of an Extraoral Condyle Locating Device and Its Effect on Low-Level Laser Therapy in Patients With Skeletal Class II Malocclusion: Protocol for a 2-Phase Randomized Controlled Trial. PG - e94481 LID - 10.2196/94481 [doi] LID - e94481 AB - BACKGROUND: Precise localization of the mandibular condyle is essential for extraoral therapeutic procedures such as low-level laser therapy (LLLT) in patients with skeletal class II malocclusion undergoing myofunctional appliance therapy. Conventional localization methods rely on palpation and visual estimation, which are operator dependent and may compromise reproducibility and treatment outcomes. To address this limitation, a spectacle-mounted extraoral condyle locating device (EOCLD) has been developed to facilitate accurate and consistent condylar targeting. OBJECTIVE: This study aims to develop and validate the EOCLD for precise condylar localization and evaluate its impact on the clinical efficacy of LLLT in patients with skeletal class II malocclusion undergoing myofunctional appliance therapy. METHODS: This 2-phase study will be conducted in patients aged 10 to 13 years in a growth phase with skeletal class II malocclusion. In phase 1, the EOCLD will be evaluated for accuracy and reproducibility using standardized lateral cephalometric imaging. In phase 2, a prospective randomized controlled trial will be conducted in which participants undergoing myofunctional appliance therapy will be randomly allocated to either EOCLD-guided LLLT or conventional unguided LLLT. Skeletal and dentoalveolar changes will be assessed using standardized cephalometric analyses, while condylar growth and mandibular changes will be evaluated using pretreatment and posttreatment cone beam computed tomography (CBCT) imaging. Treatment duration, patient-reported comfort, and compliance will also be assessed. RESULTS: The study is self-funded and received approval from the institutional ethics committee on November 28, 2025. Phase 1 data collection took place from May 21 to August 30, 2026, with EOCLD validation performed in 50 participants. As of September 2026, the data are undergoing statistical analysis. Phase 2 is scheduled to commence on December 1, 2026. CONCLUSIONS: This study will establish the clinical validity of the EOCLD and determine whether guided LLLT enhances treatment efficiency and skeletal outcomes in skeletal class II therapy. TRIAL REGISTRATION: Clinical Trials Registry-India CTRI/2026/02/102982; https://tinyurl.com/4t3bwrnz. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/94481. CI - (c)Shilpa Kendre, Pallavi Daigavane. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 02.10.2026. FAU - Kendre, Shilpa AU - Kendre S AUID- ORCID: 0000-0002-4024-1744 AD - Department of Orthodontics, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Daigavane, Pallavi AU - Daigavane P AUID- ORCID: 0000-0001-7205-8154 AD - Department of Orthodontics, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20261002 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Cephalometry/methods MH - *Low-Level Light Therapy/methods/instrumentation MH - *Malocclusion, Angle Class II/therapy MH - *Mandibular Condyle/diagnostic imaging MH - Randomized Controlled Trials as Topic MH - Reproducibility of Results MH - Validation Studies as Topic PMC - PMC13675681 OTO - NOTNLM OT - CBCT OT - EOCLD OT - LLLT OT - condylar growth OT - condylar localization OT - cone beam computed tomography OT - extraoral condyle locating device OT - functional orthopedics OT - laser-assisted orthodontics OT - low-level laser therapy OT - myofunctional appliance therapy OT - randomized controlled trial OT - skeletal class II COIS- Conflicts of Interest: None declared. EDAT- 2026/10/02 17:30 MHDA- 2026/10/02 23:30 PMCR- 2026/10/02 CRDT- 2026/10/02 16:53 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/06/03 00:00 [revised] PHST- 2026/10/02 23:30 [medline] PHST- 2026/10/02 17:30 [pubmed] PHST- 2026/10/02 16:53 [entrez] PHST- 2026/10/02 00:00 [pmc-release] AID - v15i1e94481 [pii] AID - 10.2196/94481 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 2;15:e94481. doi: 10.2196/94481. PMID- 42825020 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Liver transplantation-related osteoporosis and fragility fractures: pathogenic pathways, risk stratification and novel targeted therapy advances. PG - 1965784 LID - 10.3389/fimmu.2026.1965784 [doi] LID - 1965784 AB - Liver transplantation (LT) serves as the definitive treatment for end-stage liver disease. Yet, osteoporosis (OP) and fragility fractures remain frequently overlooked skeletal complications that may impair the long-term prognosis of recipients. This review systematically summarizes recent evidence regarding epidemiological characteristics, multifactorial pathogenic pathways, risk stratification approaches, and advances in targeted interventions for LT-related bone disorders. Skeletal damage distributes across pre-transplant waiting, early post-transplant acute and long-term chronic phases; rapid bone loss and elevated fracture risk potentially peak within the first year after LT. Pre-transplant hepatic dysfunction-induced malnutrition, endocrine disturbance, and chronic inflammation lay baseline skeletal impairment. In contrast, perioperative high-dose glucocorticoids, calcineurin inhibitor toxicity, surgical denervation, and ischemia-reperfusion injury may jointly drive substantial elevation of bone turnover in the early post-transplant stage. Long-term cortical bone repair deficiency could be attributed to persistent secondary hyperparathyroidism, post-transplant diabetes, and genetic susceptibility. Dual-energy X-ray absorptiometry remains the standard bone mineral density diagnostic tool, while vertebral computed tomography attenuation value and simplified clinical scoring systems support auxiliary risk stratification for skeletal health. Generalized nutritional and lifestyle interventions combined with anti-resorptive agents form mainstream management schemes; DKK-1/Wnt/beta-catenin pathway-targeted therapy shows potential as a novel intervention direction. Pediatric LT recipients feature unique bone maturation characteristics that require age-specific evaluation criteria, though unified standardized protocols remain insufficient. Current clinical practice suffers from inadequate bone health screening and pharmacotherapy coverage. Further prospective trials are warranted to validate optimized stratified screening algorithms and individualized targeted regimens for high-risk LT populations. CI - Copyright (c) 2026 Wang and Wang. FAU - Wang, Meiqi AU - Wang M AD - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China. FAU - Wang, Qi AU - Wang Q AD - Department of Donation Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. LA - eng PT - Journal Article PT - Review DEP - 20260917 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Liver Transplantation/adverse effects MH - *Osteoporosis/etiology/therapy/epidemiology/diagnosis MH - *Osteoporotic Fractures/etiology/therapy MH - Risk Assessment MH - Risk Factors MH - Animals MH - Bone Density PMC - PMC13628645 OTO - NOTNLM OT - Wnt/beta-Catenin pathway OT - bone mineral density OT - fragility fracture OT - hepatic osteodystrophy OT - liver transplantation OT - osteoporosis OT - risk stratification COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 07:06 PHST- 2026/08/12 00:00 [received] PHST- 2026/09/01 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 07:06 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1965784 [doi] PST - epublish SO - Front Immunol. 2026 Sep 17;17:1965784. doi: 10.3389/fimmu.2026.1965784. eCollection 2026. PMID- 42824923 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Predictors of treatment response to semaglutide for weight management. PG - 1893511 LID - 10.3389/fendo.2026.1893511 [doi] LID - 1893511 AB - The emergence of weekly, injectable glucagon-like peptide-1 (GLP-1) receptor agonists has revolutionized the obesity management landscape. Numerous studies have shown high efficacy as well as great variability in weight loss, highlighting the need for this mini review, summarizing current evidence about predictors of semaglutide-related weight loss. The first well-known determinant of semaglutide-induced weight loss is the presence of type 2 DM which is associated with significantly lower body weight reduction. The second predictor is sex, with females exhibiting a greater weight loss than males by a mean 6%. In addition, higher maintenance dose of 7.2 mg is superior to standard 2.4 mg dose in weight reduction by a mean 3%. There is no clear association of age and baseline body mass index with the magnitude of semaglutide-driven weight loss, except for the possibility of adolescence enhancing and overweight reducing this treatment effect. The potential impact of genetic polymorphisms of individual treatment response to semaglutide remains incompletely understood, limited so far to a modest effect of specific variants in GLP1 receptor gene. Another potential predictor of response could be obesity phenotype, with preliminary data supporting greater effectiveness of semaglutide in individuals with ''hungry gut'' phenotype. Type of lifestyle modification does not seem to have a significant effect on the variability of semaglutide-driven weight loss. Further studies are needed to expand knowledge about predictors of response to semaglutide, paving the way for validated predictive models in order to guide clinical decision-making and provision of personalized obesity care. CI - Copyright (c) 2026 Tzoulis. FAU - Tzoulis, Ploutarchos AU - Tzoulis P AD - Research Department of Experimental and Translational Medicine, University College London, London, United Kingdom. LA - eng PT - Journal Article PT - Review DEP - 20260917 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 53AXN4NNHX (Semaglutide) RN - 62340-29-8 (Glucagon-Like Peptides) RN - 0 (Anti-Obesity Agents) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Glucagon-Like Peptide-1 Receptor) SB - IM MH - Semaglutide MH - Humans MH - *Glucagon-Like Peptides/therapeutic use MH - *Obesity/drug therapy MH - *Weight Loss/drug effects MH - *Anti-Obesity Agents/therapeutic use MH - Diabetes Mellitus, Type 2/drug therapy MH - Glucagon-Like Peptide-1 Receptor Agonists MH - Treatment Outcome MH - Glucagon-Like Peptide-1 Receptor/genetics PMC - PMC13628350 OTO - NOTNLM OT - GLP-1 agonist OT - antiobesity agent OT - obesity OT - semaglutide OT - weight loss COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:36 MHDA- 2026/10/02 13:37 PMCR- 2026/09/17 CRDT- 2026/10/02 06:56 PHST- 2026/05/28 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/10/02 13:37 [medline] PHST- 2026/10/02 13:36 [pubmed] PHST- 2026/10/02 06:56 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fendo.2026.1893511 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 17;17:1893511. doi: 10.3389/fendo.2026.1893511. eCollection 2026. PMID- 42824878 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261002 LR - 20261003 IS - 1662-5161 (Print) IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 20 DP - 2026 TI - Development, validation and effectiveness of a parents led neuromotor training module with AI-based movement analysis for improving motor proficiency and sports participation in children with developmental coordination disorder: a protocol for an assessor-blinded randomized superiority controlled trial. PG - 1931622 LID - 10.3389/fnhum.2026.1931622 [doi] LID - 1931622 AB - INTRODUCTION: Developmental Coordination Disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination, poor balance, reduced participation in physical activities, and limitations in functional performance. Conventional rehabilitation often requires prolonged therapist supervision and may not be consistently accessible, particularly in resource-limited settings. Parent-led rehabilitation and artificial intelligence (AI)-based movement analysis have emerged as promising approaches to enhance motor outcomes; however, evidence integrating these strategies remains limited. This manuscript presents the protocol for a randomized controlled trial evaluating a structured Parent-Led Neuromotor Training Programme integrated with AI-based movement analysis in children with DCD. METHODS AND ANALYSIS: This protocol describes an assessor-blinded, two-arm, parallel-group randomized superiority controlled trial involving 62 children aged 7-14 years diagnosed with DCD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria and scoring below the age-expected range on the Movement Assessment Battery for Children-Second Edition (MABC-2). Participants will be randomly allocated (1:1) to either an intervention group receiving a Parent-Led Neuromotor Training Programme integrated with AI-based movement analysis in addition to conventional physiotherapy or a control group receiving conventional physiotherapy alone. Parents will deliver supervised home-based training for 30-45 min per session, 5 days per week, for 12 weeks. Movement analysis will be performed using Google MediaPipe Pose, a validated markerless pose-estimation framework, to quantify joint kinematics, movement symmetry, coordination, movement smoothness, movement accuracy, movement speed, and task-completion time from standardized video recordings. The primary outcome will be motor proficiency, assessed using the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2). Secondary outcomes will include AI-based movement metrics such as symmetry index, movement variability, and coordination score, as well as parental adherence, engagement, satisfaction, balance, and agility outcomes, parental adherence and satisfaction, and AI-derived movement metrics. The sample size was calculated to detect a clinically meaningful between-group difference with 80% power at a 5% significance level. Statistical analyses will follow the intention-to-treat principle, with linear mixed-effects models used to compare repeated measurements between groups. Missing data will be handled using appropriate imputation methods where necessary. CLINICAL TRIAL REGISTRATION: https://ctri.nic.in/Clinicaltrials/regtrial.php?trialid=164461&EncHid=98252.11023&modid=1&compid=19 Identifier [CTRI/2026/06/112632]. CI - Copyright (c) 2026 Hullumani and Qureshi. FAU - Hullumani, Sharath AU - Hullumani S AD - Department of Pediatrics Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute Higher Education and Research (DU), Wardha, India. FAU - Qureshi, Irshad AU - Qureshi I AD - Department of Neuro Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute Higher Education and Research (DU), Wardha, India. LA - eng PT - Journal Article DEP - 20260911 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC13628172 OTO - NOTNLM OT - DCD OT - artificial intelligence OT - developmental coordiantion disorder OT - media pipe OT - neuromotor training OT - parent led OT - physical therapy OT - therapist supervision COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/11 CRDT- 2026/10/02 06:52 PHST- 2026/07/08 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 06:52 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.3389/fnhum.2026.1931622 [doi] PST - epublish SO - Front Hum Neurosci. 2026 Sep 11;20:1931622. doi: 10.3389/fnhum.2026.1931622. eCollection 2026. PMID- 42824713 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261002 LR - 20261004 IS - 2666-142X (Electronic) IS - 2666-142X (Linking) VI - 11 DP - 2026 Dec TI - Background and design of the empowering cardiovascular health in grandfamilies (ECHG) study: A mixed methods study research protocol. PG - 100654 LID - 10.1016/j.ijnsa.2026.100654 [doi] LID - 100654 AB - A steady increase in the number of grandparent caregivers - accelerated by recent trends such as children orphaned by the COVID-19 pandemic or the opioid crisis - magnifies the importance of addressing cardiovascular disease (CVD) risk in that already at high-risk group. However, few efforts have directly addressed the specific cardiac health needs of grandparent primary caregivers (or custodial grandparents). In this paper, we describe the research protocol for the Rural Caregiver Heart Health Education (RICHH) intervention for implementation with grandparent caregivers (RICHH-GP) study funded by the National Institute of Heart, Lung, and Blood. This study will tailor an existing CVD risk reduction intervention (RICHH) for implementation with grandparent primary caregivers and then test the modified design for feasibility, acceptability, and preliminary efficacy. The expected outcome of RICHH-GP is to establish the groundwork for an expanded future clinical trial in which we will test effectiveness with a longer follow-up and with increased inclusivity of participants from marginalized populations. The specific aims are: 1) modify the RICHH intervention to target custodial grandparents from a variety of backgrounds; 2) employ the tailored intervention and assess its feasibility and acceptability via a 2-arm randomized controlled trial; 3) test the preliminary efficacy of RICHH-GP based on measures of CVD risk (physical activity, dietary intake, nicotine exposure, sleep, body mass index, lipids, blood pressure, and HbA1c), self-management behaviors, and depressive symptoms at 4- and 6-months compared to baseline and; 4) (exploratory) examine the proximal impact of the RICHH-GP intervention on CVD risk and depressive symptoms on a subsample of grandchildren of the grandparent participants. The ultimate objectives of this work are to prevent CVD-related morbidity and mortality and overall physical decline, improve psychological well-being among grandparent caregivers, and foster a more heart-healthy environment in grandfamilies. CI - (c) 2026 The Authors. FAU - Song, MinKyoung AU - Song M AD - School of Nursing, Oregon Health & Science University, Portland, OR, USA. FAU - Hansen, Lissi AU - Hansen L AD - School of Nursing, Oregon Health & Science University, Portland, OR, USA. FAU - Musil, Carol M AU - Musil CM AD - Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA. FAU - Dieckmann, Nathan F AU - Dieckmann NF AD - School of Nursing, Oregon Health & Science University, Portland, OR, USA. FAU - Rosenkranz, Susan J AU - Rosenkranz SJ AD - School of Nursing, Oregon Health & Science University, Portland, OR, USA. FAU - Moser, Debra K AU - Moser DK AD - College of Nursing, University of Tennessee, Knoxville, Knoxville, TN, USA. LA - eng GR - R34 HL177243/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260812 PL - England TA - Int J Nurs Stud Adv JT - International journal of nursing studies advances JID - 101769252 PMC - PMC13629207 OTO - NOTNLM OT - Cardiovascular diseases OT - Caregivers OT - Grandparents OT - Randomized controlled trial COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/02 13:36 MHDA- 2026/10/02 13:37 PMCR- 2026/08/12 CRDT- 2026/10/02 06:39 PHST- 2026/07/29 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/10/02 13:37 [medline] PHST- 2026/10/02 13:36 [pubmed] PHST- 2026/10/02 06:39 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - S2666-142X(26)00175-X [pii] AID - 100654 [pii] AID - 10.1016/j.ijnsa.2026.100654 [doi] PST - epublish SO - Int J Nurs Stud Adv. 2026 Aug 12;11:100654. doi: 10.1016/j.ijnsa.2026.100654. eCollection 2026 Dec. PMID- 42824389 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Improvements in body composition and postural control in children with obesity following an AI-assisted, deficit-oriented exercise intervention. PG - 1886988 LID - 10.3389/fpubh.2026.1886988 [doi] LID - 1886988 AB - OBJECTIVE: To investigate the effects of an AI-assisted, individualized exercise management model on body composition, physical fitness, and postural stability in children with obesity, providing a feasibility foundation for subsequent randomized controlled trials. METHODS: A single-group, pre-post pilot study was conducted. Nineteen children with simple obesity (7 girls, 12 boys; mean age 10.11 +/- 2.0 years) from West China Second Hospital (July-September 2024) completed a 12-week exercise intervention. The AI system generated individualized FITT-VP prescriptions based on baseline assessments and dynamically adjusted them via training feedback, with on-site coach implementation. Outcomes were measured pre- and post-intervention. RESULTS: All 19 children completed the intervention with no adverse events. Primary outcomes: BMI decreased from 25.29 +/- 3.56 to 23.64 +/- 3.60 kg/m(2) (p < 0.001, d = 0.46), and body fat mass from 21.06 +/- 6.70 to 17.94 +/- 6.69 kg (p < 0.001, d = 0.47). Secondary outcomes: waist circumference (p < 0.01, d = 0.31), grip strength (p < 0.01, d = 0.54), 1-min jump rope (p < 0.01, d = 1.15), 1-min sit-ups (p < 0.05, d = 1.00), and sit-and-reach (p < 0.05, d = 0.67) all improved significantly. In the eight-directional postural control assessment, endpoint excursion and maximum excursion exhibited improvement trends in all directions, and reaction time was significantly reduced in four directions (p < 0.05). In the Sensory Organization Test, the mean balance percentages for SOT-4 and SOT-5 significantly increased (p < 0.01, d = 1.05 and d = 0.58, respectively), and the composite balance score increased by 24.15% (p < 0.001, d = 1.28). The visual ratio significantly increased by 19.5% (p < 0.05, d = 0.80), whereas the vestibular ratio increased by 15.3%, approaching but not reaching statistical significance (p = 0.054, d = 0.43). CONCLUSION: The AI-assisted, deficit-oriented exercise intervention demonstrated good feasibility and safety in this cohort of children with obesity. The observed improvements in body composition, motor function, and postural control indicators provide a feasibility basis for subsequent confirmatory trials on precision exercise management for childhood obesity. CI - Copyright (c) 2026 Cao, Cheng, Deng, Ren, Zhang and Li. FAU - Cao, Lixin AU - Cao L AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Cheng, Xingxing AU - Cheng X AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Deng, Changqing AU - Deng C AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Ren, Yuexin AU - Ren Y AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Zhang, Shunjiu AU - Zhang S AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Li, Lunyu AU - Li L AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. LA - eng PT - Journal Article DEP - 20260917 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - *Body Composition/physiology MH - *Postural Balance/physiology MH - *Pediatric Obesity/therapy MH - Physical Fitness/physiology MH - Body Mass Index MH - Pilot Projects MH - Artificial Intelligence MH - Humans MH - Male MH - Female MH - Child PMC - PMC13627403 OTO - NOTNLM OT - AI-assisted decision support system OT - childhood obesity OT - deficit-oriented OT - postural control OT - precision exercise intervention COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 06:06 PHST- 2026/05/21 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 06:06 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1886988 [doi] PST - epublish SO - Front Public Health. 2026 Sep 17;14:1886988. doi: 10.3389/fpubh.2026.1886988. eCollection 2026. PMID- 42824331 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Predicting metabolic syndrome in adolescents from device-measured 24-h movement behaviors: a machine learning approach. PG - 1928562 LID - 10.3389/fpubh.2026.1928562 [doi] LID - 1928562 AB - OBJECTIVE: To develop and internally evaluate a non-invasive machine-learning model for identifying metabolic syndrome (MS) in adolescents using 24-h movement behaviors and non-invasively measured physical characteristics. METHODS: This cross-sectional study included 822 adolescents aged 12-15 years recruited in Tianjin, China, from September 2023 to September 2025. Movement behaviors were assessed using ActiGraph GT3X+ accelerometers, body composition was measured using dual-energy X-ray absorptiometry, and MS was diagnosed according to the 2007 International Diabetes Federation criteria. LASSO regression was used for feature selection, and 13 machine-learning algorithms were compared. SMOTETomek was used during model development to address class imbalance. Performance was evaluated using stratified five-fold cross-validation and a held-out internal test set. SHapley Additive exPlanations (SHAP) were used to interpret model predictions. RESULTS: LASSO retained eight predictors: waist circumference, body fat percentage (FAT%), weight, age, moderate physical activity (MPA), vigorous physical activity, sleep duration, and sex. Extra Trees achieved the best cross-validation performance, with a mean AUC of 0.749 (SD, 0.043) and an F1 score of 0.798 (SD, 0.028). Its relative advantage may reflect the ability of randomized tree ensembles to capture nonlinear relationships and feature interactions while reducing variance through aggregation. In the held-out internal test set, the model achieved an AUC of 0.864, accuracy of 92.02%, specificity of 93.33%, and sensitivity of 76.92%. The lower sensitivity relative to accuracy and specificity indicates that some adolescents with MS may remain undetected. SHAP ranked FAT% as the most influential predictor (mean absolute SHAP value, 0.08) and MPA as the leading movement-behavior predictor (0.04), thereby improving the transparency of model predictions. CONCLUSIONS: The Extra Trees model showed moderate cross-validation discrimination and stronger performance in the internal test set, although this difference warrants cautious interpretation. SHAP improved model transparency by identifying FAT% and MPA as influential predictors. Multicenter external validation and feasibility assessment are required before large-scale screening. CI - Copyright (c) 2026 Cao, Feng, Wang and Wang. FAU - Cao, Liquan AU - Cao L AD - Tianjin University of Sport, Tianjin, China. AD - Tianjin Key Laboratory of Sports and Health Integration and Health Promotion, Tianjin, China. FAU - Feng, Zhanpeng AU - Feng Z AD - Tianjin University of Sport, Tianjin, China. AD - Tianjin Key Laboratory of Sports and Health Integration and Health Promotion, Tianjin, China. FAU - Wang, Jing AU - Wang J AD - Tianjin University of Sport, Tianjin, China. FAU - Wang, Yun AU - Wang Y AD - Tianjin University of Sport, Tianjin, China. LA - eng PT - Journal Article DEP - 20260917 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Metabolic Syndrome/diagnosis MH - Adolescent MH - *Machine Learning MH - Cross-Sectional Studies MH - Female MH - Male MH - China MH - Predictive Learning Models MH - Child MH - *Exercise/physiology MH - Accelerometry MH - Absorptiometry, Photon MH - Prediction Algorithms PMC - PMC13627327 OTO - NOTNLM OT - 24-hour movement behaviors OT - SHAP OT - adolescent OT - machine learning OT - metabolic syndrome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 05:59 PHST- 2026/07/05 00:00 [received] PHST- 2026/08/23 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 05:59 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1928562 [doi] PST - epublish SO - Front Public Health. 2026 Sep 17;14:1928562. doi: 10.3389/fpubh.2026.1928562. eCollection 2026. PMID- 42824137 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Mediating role of peripheral thyroid hormone conversion efficiency in the association between BMI and IGF-1 in children with growth retardation: a cross-sectional study. PG - 1941425 LID - 10.3389/fendo.2026.1941425 [doi] LID - 1941425 AB - OBJECTIVE: To examine the association between body mass index (BMI) standard deviation score (SDS) and insulin-like growth factor-1 (IGF-1) SDS and whether thyroid hormones mediate it, focusing on the peripheral conversion marker free triiodothyronine/free thyroxine (FT3/FT4) ratio, in prepubertal children (2.0-9.0 years) with height SDS < -1.0. METHODS: This retrospective cross-sectional study included 1,242 such children. Restricted cubic splines assessed the BMI-IGF-1 relationship, and Bootstrap mediation (5,000 resamples) tested indirect effects of FT3/FT4, FT3, FT4, and thyroid-stimulating hormone (TSH), adjusted for sex, age and height SDS. Reverse mediation, subgroup, interaction, Monte Carlo power, and E-value sensitivity analyses were also performed. RESULTS: A significant linear positive association was found (P-overall < 0.001; P-nonlinear = 0.0719). FT3/FT4 and FT3 showed significant partial mediation, accounting for 9.12% (P < 0.001) and 11.60% (P = 0.0108) of the total effect, respectively; TSH and FT4 did not. Sensitivity analyses confirmed robustness after stricter prepubertal cutoffs and exclusion of overweight/obese children. Notably, only FT3/FT4 remained significant after excluding suspected Growth Hormone Deficiency (GHD) (IGF-1 SDS < -2.0). The FT3/FT4 ratio remained a significant mediator across all subgroup analyses. Reverse mediation analysis yielded a substantially smaller indirect effect in the reverse direction. E-values for FT3/FT4 and FT3 were 1.0764 and 1.0609, respectively. CONCLUSION: In this growth-retarded prepubertal cohort, BMI and IGF-1 are linearly associated. The FT3/FT4 ratio is statistically supported as a partial mediator with moderate effect size but strong statistical robustness, while the central TSH pathway is uninvolved, supporting a peripheral "thrifty" regulatory strategy and offering a potential target for nutritional intervention. These mediation findings reflect statistical associations and require prospective validation. CI - Copyright (c) 2026 Zhang and Liu. FAU - Zhang, Mengying AU - Zhang M AD - Department of Child Health Care; Clinical Research Center of Child Health Care and Developmental & Behavioral Disorders, Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Liu, Hua AU - Liu H AD - Department of Child Health Care; Clinical Research Center of Child Health Care and Developmental & Behavioral Disorders, Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. LA - eng PT - Journal Article DEP - 20260917 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 0 (Thyroid Hormones) RN - 0 (IGF1 protein, human) RN - Q51BO43MG4 (Thyroxine) RN - 06LU7C9H1V (Triiodothyronine) SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Insulin-Like Growth Factor I/metabolism/analysis MH - Female MH - *Body Mass Index MH - Child MH - Retrospective Studies MH - Child, Preschool MH - Male MH - *Growth Disorders/blood/metabolism MH - *Thyroid Hormones/blood/metabolism MH - Thyroxine/blood MH - *Triiodothyronine/blood PMC - PMC13627020 OTO - NOTNLM OT - FT3/FT4 ratio OT - body mass index OT - growth retardation OT - insulin-like growth factor-1 OT - mediation analysis OT - prepubertal children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 05:30 PHST- 2026/07/18 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 05:30 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fendo.2026.1941425 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 17;17:1941425. doi: 10.3389/fendo.2026.1941425. eCollection 2026. PMID- 42823676 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Aug 13 TI - Artificial intelligence attitudes in relation to Mediterranean diet adherence and environmental footprints: a cross-sectional study. LID - 10.1186/s12889-026-28997-4 [doi] LID - 2730 AB - OBJECTIVE: This study aimed to evaluate the relationship between attitudes towards artificial intelligence and adherence to the Mediterranean Diet (MD), carbon footprint awareness and environmental footprint awareness among adults. METHODS: This cross-sectional study was conducted in Ankara, Turkey, using snowball sampling and an online questionnaire. The study included 1350 adults aged 18-65 years. Data were collected through a questionnaire containing demographic information, self-report anthropometric measurements, and validated scales. Artificial Intelligence Attitude Scale, Ecological Footprint Awareness Scale, Carbon Footprint Awareness Scale, and Mediterranean Diet Adherence Scale (MEDAS) were used in the study. RESULTS: Of the participants, 76.7% were female and 23.3% were male. Participants with adequate MD adherence (MEDAS >/= 7) were older, had higher BMI, and demonstrated higher ecological and carbon footprint awareness than those with lower adherence. AIAS-4 scores were similar between the MD adherence groups despite a weak negative correlation between AI attitudes and MEDAS scores (rho = -0.057, p = 0.037). AI attitudes were positively correlated with ecological (rho = 0.091, p < 0.001) and carbon footprint awareness (rho= 0.058, p = 0.032). In the multivariable linear regression model, ecological footprint awareness was independently associated with age (B = 0.229, p < 0.001), AIAS-4 (B = 1.151, p < 0.001), carbon footprint awareness (B = 1.331, p < 0.001), and male gender (B = - 4.186, p = 0.002), whereas MD adherence, education level, and AI use frequency were not significant predictors. The model explained 31.0% of the variance in ecological footprint awareness (R(2) = 0.310, p < 0.001). CONCLUSIONS: Positive attitudes toward artificial intelligence were associated with greater ecological and carbon footprint awareness but with slightly lower adherence to the Mediterranean diet. In contrast, greater adherence to the Mediterranean diet was positively associated with environmental footprint awareness. Carbon footprint awareness emerged as the strongest independent predictor of ecological footprint awareness. These findings provide preliminary evidence that attitudes toward artificial intelligence, dietary behavior, and environmental sustainability awareness are interrelated, although the observed associations were generally small and should be interpreted cautiously. CI - (c) 2026. The Author(s). FAU - Arslan, Neslihan AU - Arslan N AUID- ORCID: 0000-0002-1232-8009 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. akdeniz.neslihan91@gmail.com. FAU - Celik, Ozge Mengi AU - Celik OM AUID- ORCID: 0000-0002-0298-9591 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. FAU - Guler, Ummugulsum AU - Guler U AUID- ORCID: 0009-0001-3352-6047 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkey. FAU - Ekici, Emine Merve AU - Ekici EM AUID- ORCID: 0000-0001-5409-6309 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260813 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Female MH - *Diet, Mediterranean/statistics & numerical data/psychology MH - Adult MH - *Artificial Intelligence MH - Turkey MH - Adolescent MH - Aged MH - Young Adult MH - *Carbon Footprint/statistics & numerical data MH - Surveys and Questionnaires MH - *Patient Compliance/statistics & numerical data/psychology PMC - PMC13628745 OTO - NOTNLM OT - Artificial intelligence OT - Carbon footprint OT - Ecological footprint OT - Mediterranean diet COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was conducted with the approval of the University of Health Sciences Gulhane Scientific Research Ethics Committee, numbered 2025/357. Informed consent was obtained from all participants included in the study EDAT- 2026/10/02 05:31 MHDA- 2026/10/02 05:32 PMCR- 2026/08/13 CRDT- 2026/10/02 00:38 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/10/02 05:32 [medline] PHST- 2026/10/02 05:31 [pubmed] PHST- 2026/10/02 00:38 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.1186/s12889-026-28997-4 [pii] AID - 28997 [pii] AID - 10.1186/s12889-026-28997-4 [doi] PST - epublish SO - BMC Public Health. 2026 Aug 13;26(1):2730. doi: 10.1186/s12889-026-28997-4. PMID- 42823673 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Aug 3 TI - Mothers' perceptions and decision-making regarding tandem breastfeeding in Turkiye: a child health-focused qualitative study. LID - 10.1186/s12884-026-09764-0 [doi] LID - 1096 AB - BACKGROUND: Tandem breastfeeding, defined as breastfeeding two non-twin children during the same period, remains an underexplored practice in maternal and child health. Although it may be perceived as a way of maintaining breastfeeding continuity and emotional closeness with the older child, mothers may also encounter physical, emotional, practical, social and professional challenges. This study aimed to explore mothers' perceptions of tandem breastfeeding in Turkiye and to examine how these perceptions are shaped by emotional, socio-cultural, practical and healthcare-related factors. METHODS: A qualitative study design based on reflexive thematic analysis was used. Semi-structured, in-depth interviews were conducted with 21 mothers who had at least one child aged 0-2 years and were familiar with the concept of tandem breastfeeding. Mothers were recruited using purposive and snowball sampling. Current or previous direct tandem breastfeeding experience was not systematically recorded as a mother characteristic. Interviews were audio-recorded, transcribed verbatim and analysed inductively using MAXQDA 24. The study was reported in accordance with the COREQ checklist. RESULTS: Four main themes were identified: the perceived meaning of tandem breastfeeding, the perceived burden of tandem breastfeeding, social perceptions, and limited professional support. Mothers associated tandem breastfeeding with maintaining the mother-child bond, preventing abrupt weaning of the older child, and supporting a sense of fairness between siblings. They also perceived it as potentially involving physical fatigue, sleep deprivation, emotional ambivalence, increased care demands, and uncertainty regarding practical feasibility. Social norms, family attitudes, misconceptions, and limited access to evidence-based professional guidance influenced mothers' decision-making. Because direct tandem breastfeeding experience was not systematically recorded, the findings represent a combination of perceptions, beliefs, observed examples, anticipated concerns, and decision-making considerations rather than the confirmed lived experiences of a clearly defined group of tandem breastfeeding mothers. CONCLUSIONS: Tandem breastfeeding was perceived as a complex maternal and child health practice shaped by emotional, practical, socio-cultural, and healthcare-related factors. The findings provide insight into how mothers understand and evaluate tandem breastfeeding and how they approach decisions about whether to initiate or continue the practice. However, because mothers with confirmed direct tandem breastfeeding experience could not be distinguished from those expressing perceptions, expectations, or observed experiences, the findings should not be interpreted as evidence of the lived experience, feasibility, safety, or clinical outcomes of tandem breastfeeding. Further research involving clearly identified mothers with direct tandem breastfeeding experience is needed. CI - (c) 2026. The Author(s). FAU - Aslan, Meltem AU - Aslan M AUID- ORCID: 0000-0003-3847-2233 AD - Department of Midwifery, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. meltemaslan@esenyurt.edu.tr. FAU - Say, Cemile AU - Say C AUID- ORCID: 0009-0007-5717-6962 AD - Department of Midwifery, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. FAU - Navruz, Hilal Ezgi AU - Navruz HE AUID- ORCID: 0009-0009-9831-6604 AD - Department of Midwifery, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. FAU - Nigiz, Simal AU - Nigiz S AUID- ORCID: 0009-0000-7921-7744 AD - Department of Nursing, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. FAU - Kuroglu, Zeliha Ozge AU - Kuroglu ZO AUID- ORCID: 0009-0002-3104-0841 AD - Department of Midwifery, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260803 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - Qualitative Research MH - Adult MH - *Mothers/psychology MH - *Decision Making MH - Infant MH - Infant, Newborn MH - Mother-Child Relations/psychology MH - Health Knowledge, Attitudes, Practice MH - Child, Preschool MH - Young Adult MH - Child Health PMC - PMC13629073 OTO - NOTNLM OT - Breastfeeding OT - Child health OT - Motherhood OT - Qualitative research OT - Tandem breastfeeding COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Istanbul Gelisim University Ethics Committee (Decision No: 2025-06-12), and the study was conducted in accordance with the Declaration of Helsinki. Written informed consent to participate was obtained from all participants prior to data collection, including consent for audio recording of the interviews. Participation was voluntary, and participants were informed of their right to withdraw from the study at any time without consequence. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/02 05:31 MHDA- 2026/10/02 05:32 PMCR- 2026/08/03 CRDT- 2026/10/02 00:37 PHST- 2026/04/25 00:00 [received] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/10/02 05:32 [medline] PHST- 2026/10/02 05:31 [pubmed] PHST- 2026/10/02 00:37 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.1186/s12884-026-09764-0 [pii] AID - 9764 [pii] AID - 10.1186/s12884-026-09764-0 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Aug 3;26(1):1096. doi: 10.1186/s12884-026-09764-0. PMID- 42821542 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261001 LR - 20261003 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 10 DP - 2026 TI - Rapid diagnosis of pulmonary tuberculosis on induced sputum in children in a high burden setting for HIV and malnutrition. PG - e0007271 LID - 10.1371/journal.pgph.0007271 [doi] LID - e0007271 AB - Microbiological diagnosis of childhood pulmonary tuberculosis can be challenging. We investigated the accuracy of Xpert MTB/RIF Ultra on the induced sputum, focused on high-risk groups (infants, malnourished children, and those living with HIV), where data is limited. Children (under 15 years) investigated for pulmonary tuberculosis at Dora Nginza Hospital, South Africa, were prospectively enrolled between January 2018 and January 2024, and followed up for 12 months. Induced sputa were tested with liquid culture and Xpert MTB/RIF Ultra (Ultra). Children were categorized with confirmed, unconfirmed, or unlikely tuberculosis, according to NIH consensus definitions. Ultra diagnostic accuracy was calculated against culture, with analysis by high-risk subgroups. Of 636 children (median age, 27.4 (IQR 11.8-61.6) months), 173 (27.2%) were classified with confirmed TB, 384 (60.4%) with unconfirmed TB, and 79 (12.4%) with unlikely TB. There were 223 (37.8%) children underweight-for-age, 168 (26.5%) living with HIV, and 163 (25.6%) infants. Of 557 children with TB, 145 (26.0%) were confirmed on induced sputa; with 137/557 (24.6%) confirmed on Ultra (46.0%; 63/137, of which were "trace positive"), and 88/557 (15.8%), on culture. Of those confirmed, 57/145 (39.3%) were Ultra positive, culture negative - contributing 10.2% to the overall yield. Ultra performed better in children over 5 years and with weight-for-height Z-scores < -3. Overall, Ultra sensitivity was 90.9% (95%CI 82.9-96.0) and specificity, 89.6% (95%CI 86.7-92.0), with high accuracy across high-risk groups. Mortality amongst children treated for PTB was 4.9% (27/557) with aRR highest for stunted children (7.3; 95% CI, 2.2-24.2), followed by children with HIV (3.5; 95% CI, 1.6-7.5), and infants (3.3; 95% CI, 1.6-6.7). Ultra on induced sputum was feasible, with high yield and diagnostic accuracy for high-risk children. CI - Copyright: (c) 2026 Luiz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Luiz, Juaneta AU - Luiz J AUID- ORCID: 0009-0005-7921-8129 AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. AD - Department of Paediatrics, Dora Nginza Hospital, Gqeberha, South Africa. FAU - Workman, Lesley J AU - Workman LJ AUID- ORCID: 0000-0002-3433-6106 AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. FAU - Baard, Cynthia B AU - Baard CB AUID- ORCID: 0000-0002-4747-7610 AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. FAU - Hlombe, Yekiwe AU - Hlombe Y AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. AD - Department of Paediatrics, Dora Nginza Hospital, Gqeberha, South Africa. FAU - Prins, Margaretha AU - Prins M AUID- ORCID: 0009-0001-9755-9614 AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. FAU - Makubalo, Nomlindo AU - Makubalo N AD - Department of Paediatrics, Dora Nginza Hospital, Gqeberha, South Africa. FAU - Jaganath, Devan AU - Jaganath D AD - Division of Pediatric Infectious Diseases, University of California San Francisco, San Francisco, United States of America. AD - Center for Tuberculosis, Institute for Global Health Sciences, University of California San Francisco, San Francisco, United States of America. FAU - Cattamanchi, Adithya AU - Cattamanchi A AUID- ORCID: 0000-0002-6553-2601 AD - Center for Tuberculosis, Institute for Global Health Sciences, University of California San Francisco, San Francisco, United States of America. AD - Division of Pulmonary Diseases and Critical Care Medicine, University of California Irvine, Irvine, United States of America. FAU - Nicol, Mark P AU - Nicol MP AD - Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa. AD - Marshall Centre, School of Biomedical Sciences, University of Western Australia, Perth, Australia. FAU - Zar, Heather J AU - Zar HJ AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. LA - eng GR - R01 AI152161/AI/NIAID NIH HHS/United States PT - Journal Article DEP - 20261001 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC13630226 COIS- I have read the journal's policy and the authors of this manuscript have the following competing interests: DJ serves on the editorial board of PLOS Global Public Health. This did not alter the author's adherence to all PLOS Global Public Health policies on data and material sharing, and DJ was not involved in the peer review or editorial decision-making process for this manuscript. The remaining authors (JL, LJW, CBB, YH, MP, NM, AC, MPN, and HJZ) have declared that no competing interests exist. EDAT- 2026/10/02 03:09 MHDA- 2026/10/02 03:10 PMCR- 2026/10/01 CRDT- 2026/10/01 19:20 PHST- 2026/02/04 00:00 [received] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/10/02 03:10 [medline] PHST- 2026/10/02 03:09 [pubmed] PHST- 2026/10/01 19:20 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - PGPH-D-26-00364 [pii] AID - 10.1371/journal.pgph.0007271 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Oct 1;6(10):e0007271. doi: 10.1371/journal.pgph.0007271. eCollection 2026. PMID- 42819986 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261001 LR - 20261001 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - The "pro-inflammatory imprint" of ultra-processed food exposure: a review of mechanisms affecting child and adolescent health and development via the gut microbiome-inflammation axis. PG - 1843587 LID - 10.3389/fnut.2026.1843587 [doi] LID - 1843587 AB - The prevalence of ultra-processed food (UPF) consumption in pediatric diets has raised significant concerns regarding long-term health. This review examines evidence for a proposed 'pro-inflammatory imprint' involving the gut microbiome-inflammation axis. Using a structured narrative synthesis of pediatric observational evidence, adult intervention studies, preclinical research, multi-omics data, and public health evaluations, we examine associations between UPF exposure and metabolic, inflammatory, cognitive, and neurodevelopmental outcomes while distinguishing direct from indirect evidence. We propose the Pediatric-Specific Integrated Dietary Inflammatory Index (cP-IDII) as an unvalidated, hypothesis-generating research framework for integrating reproducible nutrient- and processing-related dietary exposures; downstream microbial, intestinal-barrier, inflammatory, metabolic, and immune measures are reserved for external validation. Furthermore, we discuss the role of commercial determinants and environmental factors in shaping child health. The synthesis identifies measurement gaps and complementary policy entry points across product composition, food environments, affordability, and marketing. Empirical development and external validation are required before the cP-IDII can be used for clinical, epidemiological, or public health decision-making. CI - Copyright (c) 2026 Liu, Luo, Yan, Yang, Long, Yang, He and Tao. FAU - Liu, Qinghua AU - Liu Q AD - College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China. FAU - Luo, Lijiao AU - Luo L AD - College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China. FAU - Yan, Zhiwen AU - Yan Z AD - Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Yang, Pan AU - Yang P AD - Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Long, Teng AU - Long T AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. FAU - Yang, Yuntao AU - Yang Y AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. FAU - He, Min AU - He M AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. FAU - Tao, Li AU - Tao L AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13625691 OTO - NOTNLM OT - Dietary Inflammatory Index (DII) OT - childhood obesity OT - food environment OT - gut-brain axis OT - metabolic programming OT - neurodevelopment OT - ultra-processed foods COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 03:09 MHDA- 2026/10/02 03:10 PMCR- 2026/09/16 CRDT- 2026/10/01 17:31 PHST- 2026/03/31 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/02 03:10 [medline] PHST- 2026/10/02 03:09 [pubmed] PHST- 2026/10/01 17:31 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - 10.3389/fnut.2026.1843587 [doi] PST - epublish SO - Front Nutr. 2026 Sep 16;13:1843587. doi: 10.3389/fnut.2026.1843587. eCollection 2026. PMID- 42823283 OWN - NLM STAT- Publisher LR - 20261001 IS - 1879-730X (Electronic) IS - 1879-7296 (Linking) DP - 2026 Oct 1 TI - A pilot feasibility study of awake laryngeal ultrasonography in children. LID - S1879-7296(26)00180-8 [pii] LID - 10.1016/j.anorl.2026.09.004 [doi] AB - BACKGROUND: Flexible nasal laryngoscopy is the gold standard examination for laryngeal assessment, but can be uncomfortable, poorly tolerated or even refused by children. Ultrasonography is non-invasive and well-tolerated and could provide an alternative. Data in children, however, are scarce. AIMS: To assess the feasibility of in-office ultrasonography in children for the identification of laryngeal structures using reference imaging planes, and to determine factors influencing examination quality. MATERIAL AND METHODS: A single-center non-interventional prospective pilot feasibility study of a diagnostic tool was conducted in children aged 0 to 15 years. Ultrasonographic images were evaluated by the performing operator and by a second blinded observer using recorded sequences. Qualitative data and inter-rater agreement were expressed as percentages. Association was assessed by logistic regression, with the significance threshold set at 1%. RESULTS: One hundred and forty children were included. The 5 ultrasound planes - axial glottic, subglottic and tracheal, and sagittal median and paramedian - allowed visualization of the thyroid, cricoid and arytenoid cartilage and vocal fold mobility in more than 95% of cases for both assessors. Age and gender effects differed between assessors, while BMI showed no significant effect. Calcification foci, without posterior acoustic shadowing, did not interfere with structural analysis. CONCLUSION: We demonstrated the feasibility of pediatric laryngeal ultrasonography using 5 reference planes, enabling visualization of laryngeal structures regardless of calcifications. CI - Copyright (c) 2026 Elsevier Masson SAS. All rights reserved. FAU - Shan, C AU - Shan C AD - Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, centre hospitalo-universitaire de Bordeaux, Bordeaux, France. Electronic address: constancesh31@gmail.com. FAU - Sagardoy, T AU - Sagardoy T AD - Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, centre hospitalo-universitaire de Bordeaux, Bordeaux, France. FAU - Soualhi, A AU - Soualhi A AD - Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, centre hospitalo-universitaire de Bordeaux, Bordeaux, France. LA - eng PT - Journal Article DEP - 20261001 PL - France TA - Eur Ann Otorhinolaryngol Head Neck Dis JT - European annals of otorhinolaryngology, head and neck diseases JID - 101531465 SB - IM OTO - NOTNLM OT - Flexible nasal laryngoscopy OT - Laryngeal ultrasound OT - Pediatric ENT OT - Pediatrics COIS- Disclosure of interest The authors declare that they have no competing interest. EDAT- 2026/10/01 23:30 MHDA- 2026/10/01 23:30 CRDT- 2026/10/01 22:03 PHST- 2026/10/01 23:30 [medline] PHST- 2026/10/01 23:30 [pubmed] PHST- 2026/10/01 22:03 [entrez] AID - S1879-7296(26)00180-8 [pii] AID - 10.1016/j.anorl.2026.09.004 [doi] PST - aheadofprint SO - Eur Ann Otorhinolaryngol Head Neck Dis. 2026 Oct 1:S1879-7296(26)00180-8. doi: 10.1016/j.anorl.2026.09.004. PMID- 42821264 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261004 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 10 DP - 2026 Oct 1 TI - Physical Activity and Adolescent Brain Structure, Mental Health, and Academic Outcomes. PG - e2636973 LID - 10.1001/jamanetworkopen.2026.36973 [doi] LID - e2636973 AB - IMPORTANCE: Urbanization and digitalization are contributing to reductions in the physical activity of adolescent individuals. Daily step count is an increasingly accessible and widely used metric for quantifying physical activity, yet little is known about how it is associated with mental health, academic performance, and brain health in adolescents. OBJECTIVE: To investigate the association of daily step count and future mental health and academic performance in adolescents, and whether differences in brain structure mediate these associations. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from participants in the Adolescent Brain Cognitive Development (ABCD) Study (release 5.1), a large-scale, longitudinal investigation designed to comprehensively characterize psychological and neurobiological development from late childhood to adolescence. The ABCD Study was conducted across 21 sites across the US, providing a diverse and geographically distributed sample. Participants were adolescent individuals with valid daily step count data and usable neuroimaging data collected between November 2018 to November 2020. Data were analyzed from May 2025 to August 2026. EXPOSURE: Pedometer-based measurements of average daily step count over the previous 3 weeks. MAIN OUTCOMES AND MEASURES: Linear mixed models examined associations of daily step count with mental health, academic performance, and brain structure, and assessed how these associations varied between different step count categories. Using structural equation modeling, step-count-associated brain morphology was examined to determine whether it statistically mediated the association between physical activity and mental health, and/or academic outcomes 1 year later. Dose-response associations were also examined. RESULTS: This study included 5515 adolescent participants (2640 [47.9%] female; mean [SD] age 11.93 [0.65] years) using step counters. Higher step count was associated with lower total mental health problems (B [SE], -0.080 [0.015]; t = -5.497; P < .001) and greater cortical thickness in the paracentral (B [SE], 0.057 [0.016]; t = 3.621; P < .001) and rostral anterior cingulate (B[SE], 0.052 [0.016]; t = 3.319; P = .001) regions. Further analyses showed a significant dose-response association, with progressively lower mental health problems across higher step categories compared with the under 5000-step group. Mediation analyses revealed that greater paracentral thickness statistically mediated the association between higher daily step count and fewer mental health problems 1 year later. CONCLUSIONS AND RELEVANCE: In this cohort study, higher daily step counts were associated with structural differences in the brains of adolescents, which were in turn associated with better mental outcomes prospectively. Beneficial associations for mental health appeared to accrue continuously across the observed range, with no evidence of a threshold or plateau, highlighting that every step counts and the potential value of promoting daily steps in adolescents. FAU - Li, Qingyang AU - Li Q AD - Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. FAU - Paluch, Amanda AU - Paluch A AD - Department of Kinesiology, University of Massachusetts Amherst. AD - Institute for Applied Life Sciences, University of Massachusetts Amherst. FAU - Rakesh, Divyangana AU - Rakesh D AD - Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. LA - eng PT - Journal Article DEP - 20261001 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Brain/anatomy & histology/diagnostic imaging/physiology MH - *Mental Health/statistics & numerical data MH - *Exercise/physiology/psychology MH - Longitudinal Studies MH - *Academic Performance/statistics & numerical data PMC - PMC13631767 COIS- Conflict of Interest Disclosures: None reported. EDAT- 2026/10/01 23:30 MHDA- 2026/10/01 23:31 PMCR- 2026/10/01 CRDT- 2026/10/01 19:03 PHST- 2026/10/01 23:31 [medline] PHST- 2026/10/01 23:30 [pubmed] PHST- 2026/10/01 19:03 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 2854698 [pii] AID - zoi260991 [pii] AID - 10.1001/jamanetworkopen.2026.36973 [doi] PST - epublish SO - JAMA Netw Open. 2026 Oct 1;9(10):e2636973. doi: 10.1001/jamanetworkopen.2026.36973. PMID- 42819725 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261001 LR - 20261001 IS - 2573-8488 (Electronic) IS - 2573-8488 (Linking) VI - 2026 DP - 2026 TI - Bridging the Research-Practice Gap: Diffusion and User Experience of a Digital Health Platform in Swedish Athletics. PG - 2452118 LID - 10.1155/tsm2/2452118 [doi] LID - 2452118 AB - BACKGROUND: Evidence-based health information often fails to reach everyday sports practice, leaving a gap between research and real-world application. Digital platforms can help bridge this research-practice gap by disseminating accessible and sport-specific health guidance to coaches, parents, and athletes. Frisk Friidrott, developed by the Swedish Athletics Federation, is a digital health platform providing evidence-based information on injury prevention, training, nutrition, and mental health in youth athletics. OBJECTIVE: To evaluate the diffusion and user experience of Frisk Friidrott among one group of intended end users, coaches and parents, for youth aged 12-15 years in Swedish Athletics. METHODS: A multimethods, cross-sectional study was conducted among coaches and parents of athletes aged 12-15 years. Quantitative data (n = 267) were collected through a web-based survey and analyzed descriptively. Qualitative data were obtained from open-ended survey responses (n = 40) and semistructured interviews (n = 5) and analyzed thematically. Two dimensions from the Reach, Effectiveness, Adoption, Implementation and Maintenance Sports Setting Matrix (RE-AIM-SSM framework), reach and adoption, were used to evaluate diffusion, while constructs from the Technology Acceptance Model, perceived usefulness and perceived ease of use, were applied to assess user experience. RESULTS: Thirty-one percent of respondents had heard of the platform, and 27% had initially adopted it. Adoption was higher among coaches, especially those with training in sports medicine or athletics. Adopters reported high perceived usefulness and credibility but identified navigation and structural limitations as barriers to ease of use. CONCLUSION: Passive diffusion resulted in modest reach. Integrating the platform into coach education and improving usability and promotion may enhance adoption and sustained engagement within Swedish Athletics. CI - Copyright (c) 2026 Jenny Jacobsson et al. Translational Sports Medicine published by John Wiley & Sons Ltd. FAU - Jacobsson, Jenny AU - Jacobsson J AUID- ORCID: 0000-0002-1551-1722 AD - Department of Health, Medicine and Caring Sciences Linkoping University Linkoping Sweden liu.se. AD - Athletics Research Center Linkoping University Linkoping Sweden liu.se. AD - Swedish Athletics Federation Stockholm Sweden. FAU - Nilsen, Per AU - Nilsen P AUID- ORCID: 0000-0003-0657-9079 AD - Department of Health, Medicine and Caring Sciences Linkoping University Linkoping Sweden liu.se. FAU - Carlfjord, Siw AU - Carlfjord S AUID- ORCID: 0000-0001-9116-8156 AD - Department of Health, Medicine and Caring Sciences Linkoping University Linkoping Sweden liu.se. FAU - Kowalski, Jan AU - Kowalski J AUID- ORCID: 0000-0001-5414-6556 AD - Swedish Athletics Federation Stockholm Sweden. FAU - Dahlstrom, Orjan AU - Dahlstrom O AUID- ORCID: 0000-0002-3955-0443 AD - Athletics Research Center Linkoping University Linkoping Sweden liu.se. AD - Department of Behavioural Sciences and Learning Linkoping University Linkoping Sweden liu.se. FAU - Tranaeus, Ulrika AU - Tranaeus U AUID- ORCID: 0000-0002-2102-6352 AD - Department of Physiology, Nutrition and Biomechanics The Swedish School of Sport and Health Sciences GIH Stockholm Sweden gih.se. AD - Sport Performance & Sport Medicine GIH Stockholm Sweden. LA - eng PT - Journal Article DEP - 20260930 PL - United States TA - Transl Sports Med JT - Translational sports medicine JID - 101734315 PMC - PMC13624697 OTO - NOTNLM OT - digital health OT - implementation OT - prevention OT - sports medicine OT - user experience COIS- Jenny Jacobsson is the medical coordinator at the Department for Elite and National Team at Swedish Athletics. The other authors declare no conflicts of interest. EDAT- 2026/10/01 17:29 MHDA- 2026/10/01 17:30 PMCR- 2026/09/30 CRDT- 2026/10/01 17:01 PHST- 2026/01/09 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/01 17:30 [medline] PHST- 2026/10/01 17:29 [pubmed] PHST- 2026/10/01 17:01 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - TSM22452118 [pii] AID - 10.1155/tsm2/2452118 [doi] PST - epublish SO - Transl Sports Med. 2026 Sep 30;2026:2452118. doi: 10.1155/tsm2/2452118. eCollection 2026. PMID- 42819193 OWN - NLM STAT- Publisher LR - 20261001 IS - 2589-0514 (Electronic) IS - 2095-882X (Print) IS - 2095-882X (Linking) DP - 2026 Sep 30 TI - Prediction of Prevalent Cardiovascular Disease Using Social, Environmental, and Behavioral Factors: A Vital Conditions Framework Approach. LID - 10.1002/cdt3.70069 [doi] AB - BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in the United States. We examined whether a model that classifies prevalent CVD using clinical risk factor precursors (social, environmental, and behavioral factors), age, and sex, organized according to the Vital Conditions for Health framework, demonstrates good discrimination and calibration. METHODS: In this cross-sectional study, we analyzed the 2021 Medical Expenditure Panel Survey (MEPS) Social Determinants of Health (SDOH) dataset (N = 18,435 adults). Cardiovascular disease prevalence was defined using self-reported diagnoses and International Classification of Diseases, 10th Revision (ICD-10), codes. Candidate predictors included variables from the seven Vital Conditions domains, age, and sex. Models included least absolute shrinkage and selection operator (LASSO) regression and extreme gradient boosting (XGBoost). Internal validation used stratified k-fold cross-validation and 2022 MEPS data. Discrimination and calibration were assessed using the area under the receiver operating characteristic curve (AUC), Brier score, calibration slope, calibration-in-the-large (CITL), and observed-to-expected (O:E) ratio. Subgroup performance was evaluated by age, sex, and race or ethnicity. RESULTS: Both LASSO and XGBoost performed well. LASSO achieved an AUC of 0.822 (95% confidence interval [CI], 0.815-0.831), with a calibration slope of 1.022 and an O:E ratio of 1.001. XGBoost achieved an AUC of 0.822 (95% CI, 0.814-0.831), with a calibration slope of 1.026 and an O:E ratio of 1.002. Discrimination was stable across sex and race or ethnicity subgroups, although some calibration drift occurred among Hispanic participants. Performance declined among adults aged >/= 65 years (XGBoost AUC, 0.67) compared with those aged < 65 years (AUC, 0.812). Key predictors included age, sex, exercise, social isolation, healthcare access, food insecurity, financial strain, adverse childhood experiences (ACEs), smoking, and transportation barriers. CONCLUSIONS: Models using upstream social determinants of health, age, and sex demonstrated good discrimination when classifying prevalent CVD. External and prospective validation is needed before these models can be considered for clinical or population-level screening. CI - (c) 2026 The Author(s). Chronic Diseases and Translational Medicine published by John Wiley & Sons Ltd on behalf of Chinese Medical Association. FAU - Kjelstrom, Stephanie AU - Kjelstrom S AUID- ORCID: 0000-0003-0933-4472 AD - College of Population Health Thomas Jefferson University Philadelphia Pennsylvania USA. AD - Lankenau Institute for Medical Research Wynnewood Pennsylvania USA. FAU - Hass, Richard AU - Hass R AD - College of Population Health Thomas Jefferson University Philadelphia Pennsylvania USA. FAU - Vollbrecht, Robert AU - Vollbrecht R AD - Brown University Providence Rhode Island USA. FAU - George, Brandon AU - George B AD - College of Population Health Thomas Jefferson University Philadelphia Pennsylvania USA. FAU - Larson, Sharon AU - Larson S AD - College of Population Health Thomas Jefferson University Philadelphia Pennsylvania USA. LA - eng PT - Journal Article DEP - 20260930 PL - United States TA - Chronic Dis Transl Med JT - Chronic diseases and translational medicine JID - 101679934 PMC - PMC13625146 OTO - NOTNLM OT - cardiovascular diseases OT - prediction algorithms OT - risk OT - social determinants of health COIS- The authors declare no conflicts of interest. EDAT- 2026/10/01 17:29 MHDA- 2026/10/01 17:29 PMCR- 2026/09/30 CRDT- 2026/10/01 14:15 PHST- 2026/01/05 00:00 [received] PHST- 2026/08/18 00:00 [revised] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/10/01 17:29 [medline] PHST- 2026/10/01 17:29 [pubmed] PHST- 2026/10/01 14:15 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - CDT370069 [pii] AID - 10.1002/cdt3.70069 [doi] PST - aheadofprint SO - Chronic Dis Transl Med. 2026 Sep 30:10.1002/cdt3.70069. doi: 10.1002/cdt3.70069. PMID- 42818738 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261001 LR - 20261002 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Body roundness index and adolescent metabolic syndrome: dose-response analysis and serum biomarker mediation. PG - 1930822 LID - 10.3389/fnut.2026.1930822 [doi] LID - 1930822 AB - BACKGROUND: The Body Roundness Index (BRI) combines waist circumference and height into a single geometric measure that is intended to reflect visceral adiposity. Its ability to predict metabolic syndrome (MetS) in adolescents and the biological processes that mediate this association have not been well defined. We tested the BRI-MetS relationship in Chinese adolescents, compared BRI with body mass index (BMI), and examined whether circulating biomarkers mediated this association. METHODS: This cross-sectional study recruited 914 Chinese adolescents (53.2% boys) aged 11-16 years. MetS was defined according to Chinese pediatric guidelines (CN2025) and the International Diabetes Federation (IDF) criteria. Associations and predictive performance were assessed using logistic regression, restricted cubic splines (RCS), and receiver operating characteristic (ROC) curves. Subgroup analyses were stratified by sex and BMI category. Potential mechanistic pathways involving 22 serum biomarkers were investigated by correlation networks, hierarchical clustering, and two-stage mediation models. RESULTS: BRI was positively associated with MetS (CN2025: OR = 3.63 per unit, 95%CI 2.91-4.53; IDF: OR = 2.64, 95%CI 2.14-3.26). RCS demonstrated non-linear dose-response relationship, with an acceleration in risk beyond BRI of approximately 4.0. BRI outperformed BMI in discriminating MetS (AUC 0.873 vs. 0.835, p = 0.005), especially among normal-weight participants (OR = 3.48, p < 0.001). Sex stratification showed that BRI was associated with hypertriglyceridemia and hypertension in male adolescents (p < 0.001) but not in female adolescents. We identified three biomarker co-expression modules: the upward module (ALT, FINS, and UA) mediated 52.9% of the association between BRI and hypertriglyceridemia and 54.1-59.5% of the association between BRI and hypertension; SFRP5 and irisin mediated the associations of BRI with fasting plasma glucose (FPG) and HDL-cholesterol, respectively. CONCLUSION: BRI may be a better predictor of MetS in Chinese adolescents, particularly when MetS is defined using domestic criteria. Its predictive power was greatest among normal-weight adolescents and varied by sex. Exploratory mediation analyses identified the metabolic-inflammatory axis and protective adipokines as key mediators, suggesting hypothesis-generating targets for interventions to improve adolescent metabolic health that require longitudinal validation. CI - Copyright (c) 2026 Yao, Wang, Zhou, Wang, Wang and Du. FAU - Yao, Hui AU - Yao H AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Yiwen AU - Wang Y AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Zhou, Fang AU - Zhou F AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Fei AU - Wang F AD - Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Xiaochen AU - Wang X AD - Department of Endocrinology, Liaoning Provincial People's Hospital, Shenyang, China. FAU - Du, Runyu AU - Du R AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. LA - eng PT - Journal Article DEP - 20260916 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13623853 OTO - NOTNLM OT - adipokine OT - adolescent OT - body roundness index OT - dose-response analysis OT - mediation analysis OT - metabolic syndrome OT - restricted cubic spline COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/01 11:37 MHDA- 2026/10/01 11:38 PMCR- 2026/09/16 CRDT- 2026/10/01 10:15 PHST- 2026/07/07 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/10/01 11:38 [medline] PHST- 2026/10/01 11:37 [pubmed] PHST- 2026/10/01 10:15 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - 10.3389/fnut.2026.1930822 [doi] PST - epublish SO - Front Nutr. 2026 Sep 16;13:1930822. doi: 10.3389/fnut.2026.1930822. eCollection 2026. PMID- 42818614 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261027 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Association rule analysis of food-specific IgG and clinical symptoms in pediatric patients. PG - 1940230 LID - 10.3389/fimmu.2026.1940230 [doi] LID - 1940230 AB - Food-specific immunoglobulin G (IgG) have drawn increasing attention in pediatric food intolerance study, yet population-based data and their associations with clinical symptoms remain limited. This retrospective study included 100 children (56 males, 44 females; age groups: <5 years, n=20; 5-9 years, n=50; >/=10 years, n=30) from Zhuhai, China. Serum specific IgG against 14 common foods were measured by enzyme-linked immunosorbent assay (ELISA) and classified as negative (<50 U/mL), mild (50-100 U/mL), moderate (100-200 U/mL), or severe (>/=200 U/mL). Spearman correlation and Apriori association rule analysis (minimum support 6%, minimum confidence 50%, lift >1.5) were applied. The three most prevalent food-specific IgG positivities were egg (89.0%), milk (73.0%), and wheat (48.0%). Total positivity rate of each food correlated positively with its severe proportion (r=0.8733, P<0.001). No significant differences between sex were found in positivity rates, but the correlation patterns differed. In boys, both moderate and severe proportions correlated with positivity rates, while in girls, only the severe proportion did. Age showed no significant effect on positivity rates, though food-specific IgG response intensity trend to decrease with age. The four most frequent clinical symptoms were cough-related (25 cases), nasal diseases (20 cases), tic disorder/chronic tic disorders (19 cases), and deficiency-excess complex pattern (9 cases). Association rule mining identified four strong rules; the strongest was deficiency-excess complex pattern with egg and milk co-positivity (support 7.0%, confidence 77.8%, lift 6.09). These findings suggest that egg, milk, and wheat are the predominant IgG‑positive food items in this cohort. The positive correlation between positivity rate and severe proportion, along with the strong association between deficiency-excess complex pattern and egg-milk co-positivity, may inform dietary interventions in children with food intolerance, though prospective validation is warranted. CI - Copyright (c) 2026 Zhou, Wu and Qiao. FAU - Zhou, Zidong AU - Zhou Z AD - YunKang School of Medicine and Health, Nanfang College Guangzhou, Guangzhou, Guangdong, China. AD - Department of Clinical Laboratory, Zhuhai Hospital of Traditional Chinese Medicine, Zhuhai, Guangdong, China. FAU - Wu, Hongqiu AU - Wu H AD - Department of Clinical Laboratory, Zhuhai Hospital of Traditional Chinese Medicine, Zhuhai, Guangdong, China. FAU - Qiao, Xifeng AU - Qiao X AD - YunKang School of Medicine and Health, Nanfang College Guangzhou, Guangzhou, Guangdong, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260916 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Immunoglobulin G) RN - 0 (Allergens) SB - IM MH - Humans MH - Female MH - Male MH - *Immunoglobulin G/blood/immunology MH - Child, Preschool MH - Child MH - *Food Hypersensitivity/immunology/diagnosis/blood/epidemiology MH - Retrospective Studies MH - China/epidemiology MH - Allergens/immunology PMC - PMC13623606 OTO - NOTNLM OT - association rule mining OT - children OT - clinical symptoms OT - food intolerance OT - food-specific IgG COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/01 11:37 MHDA- 2026/10/01 11:38 PMCR- 2026/09/16 CRDT- 2026/10/01 08:37 PHST- 2026/07/17 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/01 11:38 [medline] PHST- 2026/10/01 11:37 [pubmed] PHST- 2026/10/01 08:37 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1940230 [doi] PST - epublish SO - Front Immunol. 2026 Sep 16;17:1940230. doi: 10.3389/fimmu.2026.1940230. eCollection 2026. PMID- 42817819 OWN - NLM STAT- Publisher LR - 20261001 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) DP - 2026 Oct 1 TI - The grey zone before pulmonary valve replacement in repaired tetralogy of Fallot: a paediatric perspective on the 2024 American Heart Association scientific statement. PG - 1-4 LID - 10.1017/S1047951126124202 [doi] AB - The 2024 American Heart Association scientific statement broadened risk assessment in repaired tetralogy of Fallot beyond right ventricular volume, bringing together ejection fraction, exercise capacity, pressure load, and a validated risk score. One group of patients remains difficult: those whose right ventricular volumes are borderline and who meet no threshold for intervention. We describe this borderline range as a grey zone, with an indexed end-diastolic volume of approximately 140 to 160 mL/m(2) and an indexed end-systolic volume of approximately 70 to 80 mL/m(2). Within this range, no single value decides the timing of pulmonary valve replacement, and the direction of change across serial studies carries more information than any single borderline result. We outline a structured approach that places volume alongside markers of ventricular function, exercise capacity, the rhythm substrate, tissue characterisation, and loading conditions, in order to estimate the risk of continued surveillance and to set the interval to the next review. We also note that the imaging methods underlying this framework are unevenly available and unevenly taught across centres, drawing on a recent survey from the Association for European Paediatric and Congenital Cardiology, and that a framework intended for diverse centres is most useful when it separates assessments available to every unit from those available only to some. We present this framework as a way to structure reasoning at the bedside and to seed prospective multicentre study of borderline patients, rather than as a new set of cut-offs. FAU - Ulug Murt, Nujin AU - Ulug Murt N AUID- ORCID: 0000-0003-3748-8671 AD - Department of Paediatric Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. ROR: https://ror.org/03qweed85 FAU - Ramcharan, Tristan AU - Ramcharan T AUID- ORCID: 0000-0003-0197-0722 AD - Department of Paediatric Cardiology, Birmingham Children's Hospital, Birmingham, UK. AD - Cardiovascular Clinical Academic Group, City St George's, University of London, London, UK. LA - eng PT - Journal Article DEP - 20261001 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM OTO - NOTNLM OT - Tetralogy of Fallot OT - cardiovascular magnetic resonance OT - multimodality imaging OT - pulmonary valve replacement OT - right ventricular function EDAT- 2026/10/01 05:31 MHDA- 2026/10/01 05:31 CRDT- 2026/10/01 04:22 PHST- 2026/10/01 05:31 [medline] PHST- 2026/10/01 05:31 [pubmed] PHST- 2026/10/01 04:22 [entrez] AID - S1047951126124202 [pii] AID - 10.1017/S1047951126124202 [doi] PST - aheadofprint SO - Cardiol Young. 2026 Oct 1:1-4. doi: 10.1017/S1047951126124202. PMID- 42817767 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261027 IS - 1099-0496 (Electronic) IS - 8755-6863 (Print) IS - 1099-0496 (Linking) VI - 61 IP - 10 DP - 2026 Oct TI - Test-Retest Reliability, Learning Effect and Measurement Error of the Modified Shuttle Test (MST) in Children With Asthma: A Multicenter Study. PG - e71852 LID - e71852 [pii] LID - 10.1002/ppul.71852 [doi] AB - OBJECTIVE: To investigate test-retest reliability, measurement error (standard error of measurement [SEM] and minimum detectable difference [MDD]), and the learning effect of the Modified Shuttle Test (MST) in children with asthma. METHODS: Multicenter cross-sectional study including clinically stable children aged 6-12 years with asthma. Lung function and exercise capacity were assessed using MST. Intraclass Correlation Coefficient (ICC) was calculated to assess test-retest reliability. The first and second tests were compared using the paired Student's t-test to assess differences between tests. SEM and MDD were calculated to quantify measurement error. RESULTS: One hundred and twenty three children were included (71 boys [57%]; median age 9 [7-10] years). The mean distance covered in the best MST was 611 +/- 214 meters (confidence interval [95% CI] = 573-649meters). The MST showed an excellent test-retest reliability (ICC = 0.96; 95% CI: 0.95-0.97). Distance was significantly lower in the second test than in the first (574 +/- 218 vs. 601 +/- 216 m; p = 0.0001). Learning effect was -27 +/- 79 (4% +/- 14%), the SEM was 56 meters (9.5%), and the MDD was 156 m (26.6%). CONCLUSION: The MST demonstrated excellent test-retest reliability and acceptable measurement error for assessing exercise capacity in children with asthma. Although a systematic difference was observed between tests, there was no evidence of a consistent learning effect, with individual variability in repeated performance. CI - (c) 2026 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC. FAU - Radis, Lara Bezerra AU - Radis LB AUID- ORCID: 0009-0001-1333-9762 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Puzzi, Vitoria Cavalheiro AU - Puzzi VC AUID- ORCID: 0000-0002-3696-056X AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Dias, Thaila Corsi AU - Dias TC AUID- ORCID: 0009-0002-5897-4396 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Correia, Natielly Soares AU - Correia NS AUID- ORCID: 0000-0002-4757-6651 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Montes, Jessica Lane Felippe AU - Montes JLF AUID- ORCID: 0009-0000-6813-4345 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Reimberg, Mariana Mazzuca AU - Reimberg MM AUID- ORCID: 0000-0002-1187-2782 AD - University Nove de Julho, UNINOVE, Sao Paulo, Sao Paulo, Brazil. FAU - Lanza, Fernanda Cordoba AU - Lanza FC AUID- ORCID: 0000-0002-4748-6947 AD - Department of Physical Therapy, Graduate Program in Rehabilitation Sciences, University Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. FAU - de Freitas Dantas Gomes, Evelim Leal AU - de Freitas Dantas Gomes EL AUID- ORCID: 0000-0002-0636-6041 AD - Graduate Program Science Rehabilitation, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil. FAU - de Amorim, Claudio Luiz Castro Gomes AU - de Amorim CLCG AUID- ORCID: 0000-0001-7045-767X AD - Health Science Center, State University of Londrina (UEL), Londrina, Parana, Brazil. FAU - Furlanetto, Karina Couto AU - Furlanetto KC AUID- ORCID: 0000-0002-7496-7228 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. AD - Health Science Center, State University of Londrina (UEL), Londrina, Parana, Brazil. LA - eng PT - Journal Article PT - Multicenter Study PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - Child MH - *Asthma/physiopathology/diagnosis MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Male MH - Female MH - *Exercise Test/methods MH - *Exercise Tolerance/physiology PMC - PMC13628282 OTO - NOTNLM OT - asthma OT - exercise tolerance OT - pediatrics OT - reliability COIS- The authors declare no conflicts of interest. EDAT- 2026/10/01 05:31 MHDA- 2026/10/01 05:32 PMCR- 2026/10/01 CRDT- 2026/10/01 03:52 PHST- 2026/09/13 00:00 [revised] PHST- 2026/02/24 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/01 05:32 [medline] PHST- 2026/10/01 05:31 [pubmed] PHST- 2026/10/01 03:52 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - e71852 [pii] AID - PPUL71852 [pii] AID - 10.1002/ppul.71852 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 Oct;61(10):e71852. doi: 10.1002/ppul.71852. PMID- 42815717 OWN - NLM STAT- Publisher LR - 20261027 IS - 2352-3840 (Electronic) IS - 1499-2671 (Linking) DP - 2026 Sep 30 TI - Comparing Physical Activity and Sedentary Time in Children and Adolescents With Type 1 Diabetes Using Different Accelerometer Data Processing Protocols. LID - S1499-2671(26)00368-0 [pii] LID - 10.1016/j.jcjd.2026.09.005 [doi] AB - OBJECTIVE: Regular physical activity (PA) is crucial for managing type 1 diabetes (T1D), yet many children fail to achieve the recommended 60 min of daily moderate-to-vigorous PA (MVPA). Device-based (accelerometry) measurement of PA and sedentary time (SED) may be influenced by analytical decisions (e.g. cut points), but less is known about these methodological effects in children with T1D. This study aims to 1) compare the effects of different accelerometer data processing protocols on PA and SED estimates and 2) evaluate how these variations influence the proportion of children with T1D meeting PA guidelines. METHODS: Participants aged 7 to 17 years with T1D (n=43; 49% female; 13.7+/-2.3 years) wore an ActiGraph accelerometer on their right hip for 7 days. ActiLife software processed data according to 8 published protocols to classify SED, light PA (LPA), and MVPA. Linear mixed-effects models compared activity time estimates across protocols, and Cochran's Q test assessed differences in the proportion meeting PA guidelines. RESULTS: SED, LPA, and MVPA estimates differed significantly across protocols (p<0.001), with mean daily SED ranging from 438 to 700 min, LPA from 82 to 329 min, and MVPA from 16 to 193 min. Protocol choice also influenced the proportion of participants meeting the MVPA guidelines (Q(7)=172.0, n=31, p<0.001), with some methods consistently classifying more participants as meeting recommendations than others. CONCLUSIONS: This study addresses gaps in accelerometer-based research by identifying protocol-specific variability in activity measurement in children with T1D. Without criterion reference measures, it remains unclear which protocols provide the most accurate estimates. Future research should incorporate validation methods to strengthen methodological decision-making. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Sedarous, Eden AU - Sedarous E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Letts, Elyse AU - Letts E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Byra, Madelyn M AU - Byra MM AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Ball, Elizabeth AU - Ball E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - McAssey, Karen AU - McAssey K AD - Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada. FAU - Timmons, Brian W AU - Timmons BW AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. FAU - Obeid, Joyce AU - Obeid J AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. Electronic address: obeidj@mcmaster.ca. LA - eng PT - Journal Article DEP - 20260930 PL - Canada TA - Can J Diabetes JT - Canadian journal of diabetes JID - 101148810 SB - IM OTO - NOTNLM OT - cut point OT - device-based measurement OT - moderate-to-vigorous physical activity OT - pediatric chronic disease OT - wear-time validation EDAT- 2026/09/30 23:30 MHDA- 2026/09/30 23:30 CRDT- 2026/09/30 19:32 PHST- 2026/05/20 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/09/30 23:30 [pubmed] PHST- 2026/09/30 23:30 [medline] PHST- 2026/09/30 19:32 [entrez] AID - S1499-2671(26)00368-0 [pii] AID - 10.1016/j.jcjd.2026.09.005 [doi] PST - aheadofprint SO - Can J Diabetes. 2026 Sep 30:S1499-2671(26)00368-0. doi: 10.1016/j.jcjd.2026.09.005. PMID- 42815641 OWN - NLM STAT- Publisher LR - 20261028 IS - 2156-5376 (Electronic) IS - 2161-8313 (Linking) VI - 17 IP - 11 DP - 2026 Sep 30 TI - Measuring Co-coverage in Global Health and Nutrition Interventions: A Scoping Review of Analytical Approaches. PG - 100742 LID - S2161-8313(26)00156-0 [pii] LID - 10.1016/j.advnut.2026.100742 [doi] AB - Multisectoral nutrition (MSN) approaches coordinate interventions across sectors, such as health, agriculture, education, and social protection, to improve nutrition outcomes and have gained prominence in low- and middle-income countries (LMICs). Measuring co-coverage-the clustering of multiple interventions at the individual and household level-remains uncommon yet offers a viable method for tracking MSN intervention coverage. This scoping review examined existing analytic approaches and applications for assessing the co-coverage of health and nutrition interventions. We searched Web of Science Core Collection, PubMed, and EBSCOhost for studies that used, described, or developed co-coverage methods to measure nutrition- and health-related intervention coverage. Titles and abstracts were screened by 2 independent reviewers (SG and NP) using Covidence, followed by full-text screening based on predefined criteria. Screening 4478 abstracts yielded 73 eligible studies applying 8 distinct methods to quantify co-coverage across health and nutrition interventions. Most studies were observational (90%) and conducted in LMICs, particularly sub-Saharan Africa and South Asia, with publications increasing over the past decade. Data were primarily drawn from surveys (93%), particularly Demographic and Health Surveys (41 studies). Commonly included individual level interventions in co-coverage indices were antenatal care (ANC, 66 studies) or ANC components, child immunizations (48 studies), and skilled birth attendance (42 studies). Evidence on measuring a range of multisectoral interventions at the household level was limited. Intervention selection was often guided by established frameworks or guidelines. Coverage indices were calculated using simple counts, weighted averages, and scoring systems. Although 18 studies validated their indices through methods such as Cohen's kappa and sensitivity analyses, most relied on previously used approaches without specific validation. These findings underscore the considerable variability in co-coverage methodologies and the need for greater harmonization and validation to enable consistent monitoring of multisectoral nutrition progress. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Manohar, Swetha AU - Manohar S AD - Nutrition, Diet and Health Unit, International Food Policy Research Institute, Washington, DC, United States. Electronic address: smanoha2@jhu.edu. FAU - Grounds, Samantha AU - Grounds S AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Kim, Sunny S AU - Kim SS AD - Nutrition, Diet and Health Unit, International Food Policy Research Institute, Washington, DC, United States. FAU - Pandya, Niharika AU - Pandya N AD - Nutrition, Diet and Health Unit, International Food Policy Research Institute, Washington, DC, United States. FAU - Morrison, Taylor AU - Morrison T AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Nguyen, Phuong Hong AU - Nguyen PH AD - Nutrition, Diet and Health Unit, International Food Policy Research Institute, Washington, DC, United States. LA - eng PT - Journal Article PT - Review DEP - 20260930 PL - United States TA - Adv Nutr JT - Advances in nutrition (Bethesda, Md.) JID - 101540874 SB - IM OTO - NOTNLM OT - co-coverage OT - coverage OT - coverage measurement OT - maternal and child nutrition OT - multisectoral nutrition OT - nutrition and health interventions COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/09/30 23:30 MHDA- 2026/09/30 23:30 CRDT- 2026/09/30 19:29 PHST- 2025/12/13 00:00 [received] PHST- 2026/09/13 00:00 [revised] PHST- 2026/09/26 00:00 [accepted] PHST- 2026/09/30 23:30 [pubmed] PHST- 2026/09/30 23:30 [medline] PHST- 2026/09/30 19:29 [entrez] AID - S2161-8313(26)00156-0 [pii] AID - 10.1016/j.advnut.2026.100742 [doi] PST - aheadofprint SO - Adv Nutr. 2026 Sep 30;17(11):100742. doi: 10.1016/j.advnut.2026.100742. PMID- 42815152 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1460-2237 (Electronic) IS - 0268-1080 (Print) IS - 0268-1080 (Linking) VI - 41 IP - Supplement_2 DP - 2026 Sep 30 TI - Developing global measurement guidance to strengthen adolescent well-being data generation and use at country level. PG - ii57-ii68 LID - 10.1093/heapol/czaf106 [doi] AB - Adolescence is a critical life stage marked by rapid physical, cognitive, and social development with implications for well-being in adulthood and of subsequent generations. Although global attention to adolescent well-being has grown over the past decade, efforts to measure it remain fragmented, sector specific, and include a greater number of indicators of risks and negative outcomes compared to positive well-being. To address these challenges, the World Health Organization, in collaboration with the Partnership for Maternal, Newborn and Child Health and other United Nations (UN) partners, developed new measurement guidance to support countries in assessing adolescent well-being in a holistic, multisectoral way across the five domains of the UN's consensus Adolescent Well-being Framework (AWF) focused on health and nutrition, connectedness, safety, learning, and agency and resilience. This article describes the process and results of the guidance development. The process incorporated adolescent and youth perspectives, was supported by a multidisciplinary Expert Consultative Group and included several steps, starting with operationalizing the AWF for measurement. Draft guidance was then developed, and the feasibility of its implementation was assessed in Colombia, India, and South Africa. Feedback from country stakeholders led to substantial revisions-clarifying linkages to the broader measurement landscape, strengthening implementation information, and improving usability-before finalization. The guidance supports countries to identify and assemble existing data across all domains of the AWF, identify data gaps, assess current government-led efforts to improve adolescent well-being, and translate findings into action. Rather than prescribing new indicators or data collection efforts, it provides a structured approach and an Excel-based data tool to improve the use of existing data. By promoting a practical, country-led approach and building on existing systems, the guidance aims to support governments in strengthening insight, accountability, and action for adolescent well-being. CI - (c) World Health Organization, 2026. FAU - Keogh, Sarah C AU - Keogh SC AUID- ORCID: 0000-0002-2249-9565 AD - Maternal, Newborn, Child and Adolescent Health and Ageing Department, World Health Organization, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Newby, Holly AU - Newby H AUID- ORCID: 0000-0001-9195-5846 AD - Maternal, Newborn, Child and Adolescent Health and Ageing Department, World Health Organization, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Divala, Titus AU - Divala T AD - Maternal, Newborn, Child and Adolescent Health and Ageing Department, World Health Organization, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Abduvahobov, Parviz AU - Abduvahobov P AD - Division for Peace and Sustainable Development, Health and Education Section, Education Sector, United Nations Educational, Scientific and Cultural Organization, 7 Pl. de Fontenoy-UNESCO, Paris 75007, France. FAU - Baird, Sarah AU - Baird S AD - Department of Global Health, Milken Institute School of Public Health, George Washington University, 950 New Hampshire Ave NW, 4th floor, Washington, DC 20037, United States. FAU - Chatterjee, Tapas AU - Chatterjee T AD - WHO Country Office for India, Office of the WHO Representative to India, 537, A Wing, Nirman Bhawan, Maulana Azad Road, New Delhi 110 011, India. FAU - Deardorff, Julianna AU - Deardorff J AD - School of Public Health, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA 94704, United States. FAU - Degraff, Evelyne AU - Degraff E AD - Organizacion Panamericana de la Salud, Carrera 9 No. 76-49 Piso 5 oficina 501 - 502, Edificio El Nogal, Bogota D.C., Colombia. FAU - de Jong, Renee AU - de Jong R AD - Partnership for Maternal Newborn and Child Health, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Dlamini-Nqeketo, Sithembile AU - Dlamini-Nqeketo S AD - WHO Country Office for South Africa, 351 Francis Baard St, Pretoria Central, Pretoria 0002, South Africa. FAU - Engel, Danielle AU - Engel D AD - United Nations Population Fund, 730 Third Avenue, New York, NY 10017, United States. FAU - Gebremichael, Tamrat AU - Gebremichael T AD - Plan Canada, 245 Eglinton Ave E #300, Toronto, ON M4P 0B3, Canada. FAU - Karna, Priya AU - Karna P AD - WHO Country Office for India, Office of the WHO Representative to India, 537, A Wing, Nirman Bhawan, Maulana Azad Road, New Delhi 110 011, India. FAU - Klein, Jonathan D AU - Klein JD AD - Department of Pediatrics, Adolescent Medicine, Stanford University, 750 Welch Rd, Suite 210, Palo Alto, CA 94304, United States. FAU - Mackworth-Young, Constance AU - Mackworth-Young C AD - London School of Hygiene and Tropical Medicine and Biomedical Research and Training Institute, 10 Seagrave Road, Avondale, Harare, Zimbabwe. FAU - Magoro, Terrance AU - Magoro T AD - WHO Country Office for South Africa, 351 Francis Baard St, Pretoria Central, Pretoria 0002, South Africa. FAU - Mamun, Abdullah Al AU - Mamun AA AD - Poche Centre for Indigenous Health, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, 74 High St, Brisbane, QLD 4066, Australia. FAU - Marquez, Jose AU - Marquez J AD - Wellbeing Research Centre, Harris Manchester College, University of Oxford, Mansfield Rd, Oxford OX1 3TD, United Kingdom. FAU - Nenzhelele, Hlamalani Queen AU - Nenzhelele HQ AD - National Department of Health, Dr. AB Xuma Building, 1112 Voortrekker Road, Pretoria Townlands 351-JR, Pretoria 0187, South Africa. FAU - Ramirez Ruiz, Mily AU - Ramirez Ruiz M AD - Ministerio de Salud y Proteccion Social, Carrera 13 32-76, Bogota D.C. 110311, Colombia. FAU - Requejo, Jennifer AU - Requejo J AD - Global Financing Facility for Women, Children and Adolescents, World Bank Group, 1818 H Street NW, Washington, DC 20433, United States. AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, United States. FAU - Rizvi, Zoya Ali AU - Rizvi ZA AD - Adolescent Health and Nutrition Division, Ministry of Health & Family Welfare, Government of India, Nirman Bhawan, New Delhi 110011, India. FAU - Mohan, Anshu AU - Mohan A AD - Partnership for Maternal Newborn and Child Health, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Guthold, Regina AU - Guthold R AUID- ORCID: 0000-0003-3073-6468 AD - Maternal, Newborn, Child and Adolescent Health and Ageing Department, World Health Organization, 20 Avenue Appia, Geneva 1211, Switzerland. LA - eng PT - Journal Article PL - England TA - Health Policy Plan JT - Health policy and planning JID - 8610614 SB - IM MH - Humans MH - Adolescent MH - *Adolescent Health MH - Psychological Well-Being MH - Global Health MH - World Health Organization MH - United Nations PMC - PMC13626659 OTO - NOTNLM OT - adolescent data OT - adolescent health OT - global guidance OT - measurement OT - well-being COIS- Conflicts of interest: None declared. EDAT- 2026/09/30 23:30 MHDA- 2026/09/30 23:31 PMCR- 2026/09/30 CRDT- 2026/09/30 18:05 PHST- 2025/12/02 00:00 [accepted] PHST- 2026/09/30 23:31 [medline] PHST- 2026/09/30 23:30 [pubmed] PHST- 2026/09/30 18:05 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - 8845399 [pii] AID - czaf106 [pii] AID - 10.1093/heapol/czaf106 [doi] PST - ppublish SO - Health Policy Plan. 2026 Sep 30;41(Supplement_2):ii57-ii68. doi: 10.1093/heapol/czaf106. PMID- 42814958 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Sep 30 TI - Fascial Manipulation Compared to Stretching for Rehabilitation of Children With Cerebral Palsy: Protocol for a Pilot Randomized Controlled Trial. PG - e92401 LID - 10.2196/92401 [doi] LID - e92401 AB - BACKGROUND: Maintaining and improving motor function is essential in the rehabilitation of children with cerebral palsy (CP). Stretching is traditionally used to prevent muscle tightness and contractures to improve movement patterns in children with CP. Fascial manipulation (FM) is an increasingly used manual therapy method for movement difficulties associated with CP. However, evidence for FM remains limited, and its benefits over conventional stretching are unclear. A pilot randomized controlled trial (RCT) is warranted to assess the feasibility and acceptability of a definitive trial comparing FM with stretching. This study protocol describes a pilot randomized controlled feasibility trial comparing FM and stretching in children with CP to inform the design and conduct of a future definitive RCT. OBJECTIVE: The primary objective is to assess the feasibility and acceptability of the trial procedures and interventions. This includes evaluating recruitment and retention rates, intervention adherence, completion rates for outcome assessments, and the perceived impact of the interventions on children's daily functioning and participation. The secondary objective is to explore the preliminary acute and longitudinal effects of FM, compared with traditional stretching, on walking performance, gait biomechanics, joint mobility, and the variability in these outcome measures. METHODS: This pilot RCT will include 20 children aged 7 to 14 years with spastic CP, randomized to an FM intervention group (n=10) and a stretching group (n=10). Both groups will receive 1 treatment session per week for 8 weeks. Feasibility and acceptability will be assessed using quantitative measures of recruitment and retention, intervention adherence, and completion of outcome assessments, complemented by semistructured interviews with caregivers and the children's regular physiotherapists to explore perceived changes in the children's daily functioning and participation, and their experiences of the interventions. Secondary outcomes include the 6-minute walk test (6MWT), walking metabolic cost, gait biomechanics, ankle spasticity, muscle activity, joint stiffness, and functional mobility in daily life. Acute outcomes will be assessed before and after the first intervention session, while longitudinal outcomes will be assessed at baseline and following the 8-week intervention period. RESULTS: Recruitment of participants began in October 2024, with 3 additional participants required to reach the target sample size. Results are expected to be published in 2027. CONCLUSIONS: This pilot RCT will provide essential feasibility data and preliminary estimates of potential treatment effects to inform the design of a future adequately powered RCT. To our knowledge, evidence regarding the effects of FM on gait, mobility, and function in children with CP remains limited. This study aims to contribute to the development of evidence-based rehabilitation strategies for children with CP. CI - (c) Karin von Smitten-Stubb, Joachim Ring, Piia Haakana, Heikki Hurri, Mira Huusko, Ira Jeglinsky-Kankainen, Jyrki Kettunen, Juha-Pekka Kulmala, Taru Laakso, Tiina Lahtinen-Suopanki, Essi Marttinen Rossi, Helena Maenpaa, Tuula Niemela, Mika Peltoniemi, Leena Ristolainen, Petri Salonen, Eva Teijonsalo, Nita Tolvanen. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - von Smitten-Stubb, Karin AU - von Smitten-Stubb K AUID- ORCID: 0009-0000-7359-4709 AD - University of Helsinki, Helsinki, Uusimaa, Finland. FAU - Ring, Joachim AU - Ring J AUID- ORCID: 0000-0002-1557-5152 AD - Arcada University of Applied Sciences, Helsinki, Uusimaa, Finland. FAU - Haakana, Piia AU - Haakana P AUID- ORCID: 0000-0003-0005-3834 AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Hurri, Heikki AU - Hurri H AUID- ORCID: 0000-0002-1672-6960 AD - Research Institute Orton, Helsinki, Finland. FAU - Huusko, Mira AU - Huusko M AUID- ORCID: 0000-0003-2726-7250 AD - Finnish Education Evaluation Centre, Helsinki, Finland. FAU - Jeglinsky-Kankainen, Ira AU - Jeglinsky-Kankainen I AUID- ORCID: 0000-0002-2162-4168 AD - Arcada University of Applied Sciences, Helsinki, Uusimaa, Finland. FAU - Kettunen, Jyrki AU - Kettunen J AUID- ORCID: 0000-0002-4155-7150 AD - Research Institute Orton, Helsinki, Finland. FAU - Kulmala, Juha-Pekka AU - Kulmala JP AUID- ORCID: 0000-0003-1881-4689 AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Laakso, Taru AU - Laakso T AUID- ORCID: 0009-0001-4824-873X AD - Terapia-asema Voima Oy, Espoo, Finland. FAU - Lahtinen-Suopanki, Tiina AU - Lahtinen-Suopanki T AUID- ORCID: 0009-0003-5871-1622 AD - Independent physiotherapist, Helsinki, Finland. FAU - Rossi, Essi Marttinen AU - Rossi EM AUID- ORCID: 0000-0002-7811-875X AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Maenpaa, Helena AU - Maenpaa H AUID- ORCID: 0009-0005-5505-3489 AD - Motion Analysis Laboratory, Helsinki University Hospital, Helsinki, Finland. AD - University of Helsinki, Children and Adolescent, Helsinki, Finland. FAU - Niemela, Tuula AU - Niemela T AUID- ORCID: 0009-0007-5873-5295 AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Peltoniemi, Mika AU - Peltoniemi M AUID- ORCID: 0009-0001-6582-1817 AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Ristolainen, Leena AU - Ristolainen L AUID- ORCID: 0000-0002-3041-260X AD - Research Institute Orton, Helsinki, Finland. FAU - Salonen, Petri AU - Salonen P AUID- ORCID: 0009-0001-0970-7876 AD - Research Institute Orton, Helsinki, Finland. FAU - Teijonsalo, Eva AU - Teijonsalo E AUID- ORCID: 0009-0001-2032-1325 AD - Terapia-asema Voima Oy, Espoo, Finland. FAU - Tolvanen, Nita AU - Tolvanen N AUID- ORCID: 0009-0004-5405-2348 AD - Independent physiotherapist, Helsinki, Finland. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260930 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Cerebral Palsy/rehabilitation/physiopathology MH - Child MH - Pilot Projects MH - Adolescent MH - Female MH - *Muscle Stretching Exercises MH - Male MH - Randomized Controlled Trials as Topic MH - Feasibility Studies MH - *Musculoskeletal Manipulations/methods PMC - PMC13626396 OTO - NOTNLM OT - cerebral palsy rehabilitation OT - fascial manipulation OT - range of motion OT - spasticity OT - stretching OT - walking COIS- Conflicts of Interest: The authors declare the following potential conflict of interest: NT is a self-employed physiotherapist who provides fascial manipulation treatment in her professional practice, including as an intervention provider in this study. To minimize potential bias, she was not involved in the analysis or interpretation of the study outcomes. The other authors declare no conflicts of interest. EDAT- 2026/09/30 17:32 MHDA- 2026/09/30 17:33 PMCR- 2026/09/30 CRDT- 2026/09/30 16:24 PHST- 2026/01/29 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/30 17:33 [medline] PHST- 2026/09/30 17:32 [pubmed] PHST- 2026/09/30 16:24 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - v15i1e92401 [pii] AID - 92401 [pii] AID - 10.2196/92401 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Sep 30;15:e92401. doi: 10.2196/92401. PMID- 42814774 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261002 IS - 1929-073X (Print) IS - 1929-073X (Electronic) IS - 1929-073X (Linking) VI - 15 DP - 2026 Sep 30 TI - Factors Influencing Adherence to Digital Lifestyle Interventions for Adolescents: Systematic Review and Meta-Analysis of Attrition. PG - e84822 LID - 10.2196/84822 [doi] LID - e84822 AB - BACKGROUND: Intervention studies frequently report that fewer than half of adolescent participants complete digital health interventions as intended, yet a systematic synthesis of the factors driving this low adherence across lifestyle domains is lacking. Understanding these factors is essential for informing the design of interventions that can sustain adherence and achieve meaningful behavioral outcomes. OBJECTIVE: This systematic review identified and analyzed factors influencing adherence to digital health interventions targeting key adolescent lifestyle domains: physical activity, dietary habits, obesity management, alcohol consumption, and tobacco use. METHODS: We systematically searched PubMed, PsycINFO, Embase, and CINAHL in March 2024, with the search updated in June 2026, for studies of digital interventions targeting adolescents (10-19 years). Studies were included if they reported adherence outcomes. Data on intervention characteristics, user-related factors, and adherence outcomes were extracted and narratively synthesized using a framework distinguishing intervention-related and user-related factors across 3 evidence types (statistical, descriptive, and qualitative). Study-level attrition was additionally pooled in a random-effects meta-analysis. RESULTS: A total of 116 studies, comprising 46,029 participants, were included. The average completion rate (binary measure) was 66.9% (SD 26%), while average adherence to individual intervention components was 55.2% (SD 25.5%). A meta-analysis of attrition across 108 comparisons yielded a pooled dropout of 16.9% (95% CI 13.6-20.9), with very high between-study heterogeneity and no significant moderators. Consistently reported facilitators included personalization, user-friendly design, reminders, goal setting, gamification, and human support (particularly health coaching and parental involvement). The most common barriers were technical difficulties and poor system usability. Evidence regarding the effects of intervention duration and social components on adherence was inconsistent. CONCLUSIONS: Given that adolescents frequently underuse digital health interventions, completing only about half of intervention components on average, the effectiveness of these interventions is fundamentally constrained by adherence challenges. Adherence is primarily driven by user-centered design features and robust technical performance, while the impact of social and user-related factors varies by health domain and study context. Future research should adopt standardized adherence frameworks and reporting standards to enable meaningful cross-study comparisons and the development of evidence-based engagement strategies. CI - (c) Nikolaos Boumparis, Olivia Studhalter, Philippe de Riedmatten, Inci Derya Yucel, Kleio Koutra, Katrina Champion, Ana Molina-Barcelo, Teresa de Pablo-Pardo, Haridimos Kondylakis, Michael Patrick Schaub, Andreas Triantafyllidis, Severin Haug. Originally published in the Interactive Journal of Medical Research (https://www.i-jmr.org/). FAU - Boumparis, Nikolaos AU - Boumparis N AUID- ORCID: 0000-0002-3693-0168 AD - Swiss Research Institute for Public Health and Addiction, University of Zurich, Konradstrasse 32, Zurich, 8005, Switzerland, 41 44 4481173. FAU - Studhalter, Olivia AU - Studhalter O AUID- ORCID: 0009-0005-2041-6091 AD - Swiss Research Institute for Public Health and Addiction, University of Zurich, Konradstrasse 32, Zurich, 8005, Switzerland, 41 44 4481173. FAU - de Riedmatten, Philippe AU - de Riedmatten P AUID- ORCID: 0009-0007-3319-4525 AD - Swiss Research Institute for Public Health and Addiction, University of Zurich, Konradstrasse 32, Zurich, 8005, Switzerland, 41 44 4481173. FAU - Yucel, Inci Derya AU - Yucel ID AUID- ORCID: 0000-0002-7895-0116 AD - Swiss Research Institute for Public Health and Addiction, University of Zurich, Konradstrasse 32, Zurich, 8005, Switzerland, 41 44 4481173. AD - Institute on Drug Abuse, Toxicology and Pharmaceutical Science, Ege University, Bornova/Izmir, Turkey. FAU - Koutra, Kleio AU - Koutra K AUID- ORCID: 0000-0001-9713-5013 AD - Hellenic Mediterranean University Social Applied Research and Social Work Lab, Heraklion, Greece. FAU - Champion, Katrina AU - Champion K AUID- ORCID: 0000-0001-8319-9366 AD - The Matilda Centre for Research in Mental Health and Substance Use & School of Public Health, University of Sydney, Sydney, Australia. FAU - Molina-Barcelo, Ana AU - Molina-Barcelo A AUID- ORCID: 0000-0001-5113-6475 AD - Cancer and Public Health Research Unit, Foundation for the Promotion of Health and Biomedical Research, Valencia, Spain. FAU - de Pablo-Pardo, Teresa AU - de Pablo-Pardo T AUID- ORCID: 0009-0004-7878-9643 AD - Cancer and Public Health Research Unit, Foundation for the Promotion of Health and Biomedical Research, Valencia, Spain. FAU - Kondylakis, Haridimos AU - Kondylakis H AUID- ORCID: 0000-0002-9917-4486 AD - Computer Science Department, University of Crete & Institute of Computer Science, Heraklion, Greece. FAU - Schaub, Michael Patrick AU - Schaub MP AUID- ORCID: 0000-0002-8375-4005 AD - Swiss Research Institute for Public Health and Addiction, University of Zurich, Konradstrasse 32, Zurich, 8005, Switzerland, 41 44 4481173. FAU - Triantafyllidis, Andreas AU - Triantafyllidis A AUID- ORCID: 0000-0002-6938-8256 AD - Centre for Research and Technology Hellas, Thessaloniki, Greece. FAU - Haug, Severin AU - Haug S AUID- ORCID: 0000-0002-6539-5045 AD - Swiss Research Institute for Public Health and Addiction, University of Zurich, Konradstrasse 32, Zurich, 8005, Switzerland, 41 44 4481173. LA - eng PT - Journal Article PT - Review DEP - 20260930 PL - Canada TA - Interact J Med Res JT - Interactive journal of medical research JID - 101598421 PMC - PMC13626193 OTO - NOTNLM OT - adherence OT - adolescents OT - digital health interventions OT - health promotion OT - systematic review COIS- Conflicts of Interest: None declared. EDAT- 2026/09/30 17:32 MHDA- 2026/09/30 17:33 PMCR- 2026/09/30 CRDT- 2026/09/30 13:54 PHST- 2025/09/25 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/09/30 17:33 [medline] PHST- 2026/09/30 17:32 [pubmed] PHST- 2026/09/30 13:54 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - v15i1e84822 [pii] AID - 84822 [pii] AID - 10.2196/84822 [doi] PST - epublish SO - Interact J Med Res. 2026 Sep 30;15:e84822. doi: 10.2196/84822. PMID- 42814674 OWN - NLM STAT- In-Process LR - 20260930 IS - 1423-0143 (Electronic) IS - 1420-4096 (Linking) VI - 51 IP - 1 DP - 2026 TI - Erratum. PG - 915-922 LID - 10.1159/kbr/adjag008 [doi] AB - In the article "Lipids and Lipid Metabolites in the Diagnosis, Risk Prediction, and Treatment of Chronic Kidney Disease and Acute Kidney Injury: A Narrative Review" [Kidney Blood Press Res. 2026;51:567-588. https://doi.org/10.1159/000552568] by Erfurt et al. Table 1 was incorrectly transferred during the production process. A corrected version of Table 1 is available below.Table 1.Summaries of all studies discussed, including design and outcomesReferenceDesignMethodologyMain findingsConclusionDiagnostic and prognostic role of fatty acids and their metabolites in CKDShearer et al. [36] (2012)Comparison of plasma fatty acid (FA) profiles in patients with stage 3-4 CKD (n = 10), stage 5 CKD near dialysis initiation (n = 20; one excluded for poor FA recovery), and 10 non-CKD controls from Karolinska prospective cohorts (mean follow-up for stage 5 = 2.7+/-1.7 years)FAs measured by gas chromatography; eGFR (MDRD) and FA relationships assessed using Deming orthogonal regression and Cox models (age-adjusted)Stage 5 CKD patients had lower relative abundances of polyunsaturated Fas - especially arachidonate synthesis intermediates - and lower stearic acid; EPA was lower in stage 5 vs. stage 3-4 and controls. Monounsaturated FAs showed opposing trends with declining eGFR (palmitate decreased, oleic acid increased). Nervonic acid abundance was a strong age-adjusted predictor of mortality in dialysis patientsMetabolic intermediates of arachidonic acid synthesis are reduced in CKDNervonic acid significantly predicts all-cause mortalityAfshinnia et al. [39] (2016)Nested case-control study used fasting serum from a subcohort of the CRIC cohort to identify lipidomic predictors of progression to end-stage kidney disease (ESKD)LC-MS shotgun lipidomics510 lipids detected (382 after filtering); 49 showed nominal differences between progressors and nonprogressors. Statistical selection combined t tests with FDR correction, PLS-DA, and Random Forest, and candidates were tested in logistic regression models adjusted for eGFR, UPCR, demographics, diabetes, hypertension, and heart failure. Two diacylglycerols (DAG 36:0 and DAG 32:0) were lower in progressors and each 1-SD higher level was associated with substantially reduced progression risk; monoacylglycerol MAG 16:0 was higher in progressors and associated with increased risk. Class-level findings showed enrichment and differential regulation of cholesterol esters, DAGs, and phosphatidylethanolamines, with chain length and unsaturation patterns differing between groupsMultimarker lipid panels significantly improve discrimination vs. a base model (eGFR + UPCR)Gollasch et al. [37] (2020)Comparison of fatty acid profiles in 15 healthy volunteers and 15 end-stage kidney disease (ESKD) patients on maintenance hemodialysis (HD)Venous blood collected from controls and pre-/post-HD from patients; RBC and plasma fatty acids measured by HPLC-MSESRD patients showed altered RBC and plasma fatty acid patterns: reduced EPA (C20:5 n-3) and certain n-6 species and increased very-long-chain monounsaturated fatty acids (e.g., C24:1 n-9); most free fatty acids were higher in plasma and RBCs of patients. A single HD session produced only minor changes in several total plasma saturated and n-6 fatty acids and did not meaningfully change RBC fatty acid composition or the RBC omega-3 indexTotal fatty acid levels differed significantly in RBCs from healthy controls and CKD patients, hemodialysis has no effect on plasma or RBC fatty acid levelsSikorska-Wisniewska et al. [38] (2020)Cohort (n = 134) of 3 groups: patients after renal transplantation (RTx group, n = 24), patients with CKD in stages 2-5, not on dialysis (CKD-ND group, n = 67), and controls without CKD (n = 43)Fatty acids (FA) assessed by gas chromatography-mass spectrometry; same FA analysed in samples of adipose tissue taken during the kidney transplantation procedure and compared with FA of controlsSerum omega-3 and omega-6 PUFA levels were highest in controls and lowest in RTx patients. No associations were found between GFR and FA levels. Fish intake correlated with EPA/DHA levels in some groups, but ALA intake did not correlate with serum ALA; EPA, DHA, LA, and AA generally correlated inversely with triglycerides (some correlations reached significance), while no meaningful links were found with CRP, albumin, BMI, or adipose tissue PUFA compositionRTx patients present significantly lower serum content of all the examined PUFAs, in comparison to the CKD-ND group and controlsLanzon et al. [47] (2021)Comparison of 11 severely obese patients with chronic kidney disease (OD) and 14 obese controls without CKD (O)Serum lipidomics (LC-MS) and polar metabolomics (GC-HRAM-MS)Lipidomics: 71 serum lipids differed (most increased in OD), notably rises in TGs (many unsaturated, short-/medium-chain), diglycerides (DGs), phosphatidylcholines (PCs), lysophosphatidylcholines (LysoPCs) and plasmalogens, while sphingomyelins (SMs) and phosphatidylinositols (PIs) decreased. Short-chain TGs correlated negatively with eGFR in OD; many lipids correlated with glucose in O but not in OD. Metabolomics: several essential and conditionally essential amino acids (e.g., isoleucine, lysine, proline) were higher in OD. After bariatric surgery OD patients showed lipidomic shifts toward profiles closer to O; DGs and medium-chain TGs correlated with uric acid post-surgery. Serum levels of several essential amino acids (isoleucine, lysine, threonine, valine) and some conditional amino acids fell after surgery; urine valine and glutamine decreased while hippuric acid increasedResults justify the use of lipidomics to validate possible early markers of risk of CKD in patients with severe obesityMika et al. [40] (2021)Study of 198 kidney transplant (Tx) patients (age 18-70) and 48 matched controlsAnalysis of fasting plasma fatty acid (FA) profiles by GC-MS after Folch extractionTx patients - treated with standard triple immunosuppression and excluding FA supplement users - showed distinct FA alterations vs. controls: lower long- and very-long-chain saturated and polyunsaturated FAs (many n-3/n-6 PUFA and branched-chain FAs), but higher palmitic (16:0) and certain monounsaturated FAs (16:1, 18:1). Disturbances were greatest within the first month post-transplant (Tx1M) and partially normalized by >12 months, though differences from controls persisted. PCA and hierarchical clustering clearly separated Tx and control groups. Comorbidities and clinical factors affected profilesFA profiles are significantly different between patients and controls, tendency for normalization in long-term kidney recipients, n-3 PUFA strong inverse associated with inflammationPinto et al. [41] (2021)Investigation of relationships between dialysis, sleep and 24 h heart rate variability (HRV) and LC n-3 PUFA status in hemodialysis patients (CKD stage 5) (n = 45)Pre-dialysis blood samples, measurement of erythrocyte and plasma fatty acid compositionCompared with controls, patients had higher heart rates, lower HRV, more inflammation, and lower LC n-3 PUFA levels; erythrocyte omega-3 index was low overall. While no consistent associations were found for erythrocyte O3I, EPA, or DHA with HRV, plasma DHA correlated positively with HRV during dialysis, plasma EPA with 24-h HRV, and EPA:DHA ratio, DPA(n-3), and EPA showed mixed inverse or negative associations with short-term HRV, indicating a complex relationshipImpaired EPA metabolism might contribute to sudden cardiac death (SCD) risk increase in dialysis patientsSledzinski et al. [42] (2022)Study of 35 CKD patients (19 men, 16 women; age 22-70) comparison of serum fatty acid (FA) profiles before and 3 months after deceased-donor kidney transplantationCollection of fasting serum, lipids extracted and converted to FAMEs, subsequently analyzed by GC-EI-MSTotal even-chain saturated FAs, odd- and branched-chain FAs, and total SFAs did not change, but specific FAs shifted: decreases in some 12-, 18-, and 26-carbon FAs, a rise in palmitic acid (16:0), and a significant reduction in ultra-long-chain FAs (>/=26C), especially 26:0. Total MUFAs were unchanged though 20:1 increased and the 18:1/18:0 desaturation index rose. Among PUFAs, total n-6 was stable despite decreases in DGLA (20:3n-6), ARA, and AdA (22:4n-6) while 18:2n-6 increased; total n-3 PUFAs declinedSignificant reduction in n-3 PUFAs in renal transplant recipients 3 months after transplantation, which may contribute to increased cardiovascular riskSledzinski et al. [45] (2024)Prospective study of 25 CKD patients (23 deceased-donor, 2 living-donor)Quantification of serum fatty acid (FA) profiles before kidney transplantation (KTx), 3 months after, and 6-12 months after. Samples analyzed by GC-MSTotal saturated FAs were largely unchanged except for an increase in odd-chain SFAs; very-long-chain FAs (>20C) rose by 6-12 months, whereas ultra-long-chain FAs (>/=26C) fell progressively. Total MUFAs were stable overall, but C20:1, C22:1, C24:1 increased and C18:1 trended down. Total n-3 PUFAs (including DHA) and some n-6 PUFAs (ARA, DGLA) decreased at 3 months then increased by 6-12 months; linoleic acid rose at 3 monthsFA dynamics following KTx are complex and may indicate a need for supplementationMantovani et al. [46] (2023)Follow-up of 85 post-menopausal women with non-insulin-treated T2DM and preserved kidney function at baselineSerum NEFA concentrations measured using enzymatic colorimetric method, eGFR was estimatedHigher baseline NEFA levels strongly predicted kidney function decline. Patients in the highest NEFA tertile had significantly greater risk by Kaplan-Meier analysisHigher circulating levels of NEFA strongly associated with faster kidney function declineOng et al. [43] (2023)Pooled analysis by the Fatty Acids and Outcomes Research Consortium, combination of de novo data from 19 prospective cohorts (25,570 participants without baseline CKD; median follow-up 11.3 years) to examine circulating/adipose n-3 PUFA biomarkers and risk of incident chronic kidney disease (CKD)Biomarkers (ALA, EPA, DPA, DHA) were measured by gas chromatography in various lipid compartments, and incident CKD was defined as follow-up eGFR <60 mL/min/1.73 m2 among those with baseline eGFR >/=60See "Conclusion"Meta-analyses (adjusted Cox/Poisson and linear models) showed higher seafood-derived n-3 PUFAs (EPA/DPA/DHA) were associated with lower risk of incident CKD (8% lower per interquintile range; highest vs. lowest quintile RR 0.87) and with slower annual eGFR decline; results were consistent across compartments and sensitivity analyses. ALA showed no association with incident CKD or eGFR decline. Associations were not modified by age, race, hypertension, diabetes, coronary disease, or baseline eGFRKoh et al., 2024 [44]Prospective observational cohort study, 73.419 participants without CKD and 6. 735 with CKDAnalysis of systemic PUFA levelsHigher PUFA levels - especially omega-3s like DHA - were linked to lower risk of developing CKD and reduced all-cause mortality; higher PUFA levels also correlated with younger age, female sex, nonwhite race, nonsmoking, and healthier clinical profilesAmong participants without CKD, higher plasma levels of total PUFAs are associated with a lower risk of developing CKDFatty acids, their metabolites and modulators of fatty acid metabolism in CKD managementBarden et al. [55] (2015)Double-blinded, placebo-controlled intervention, CKD patients randomized to n-3 fatty acids, CoQ, both or control, daily for 8 weeksExamination of n-3 fatty acid effects on plasma and urinary 20-HETE, plasma and urinary F2-isoprostanes, changes in blood pressureTreatment raised platelet n-3 and plasma CoQ (confirming compliance) and significantly lowered plasma 20-HETE and F2-isoprostanes (urinary levels unchanged) and reduced systolic and diastolic BP during both awake and asleep periods. Post-intervention 20-HETE was positively associated with 24-h SBP and DBP (driven by daytime BP)Identification of a plausible mechanism underlying the reduction in blood pressure observed in patients with chronic kidney disease after omega-3 fatty acid supplementationHu et al. [56] (2017)Review and meta-analysis: 9 RCT with CKD patients includedEvaluation of the benefits and risks of omega-3 fatty acid supplementationSee "Conclusion"Omega-3 supplementation significantly reduces proteinuria and lowers risk of ESKD but does not significantly affect creatinine clearance rate or eGFR. Subgroup analysis shows location, age, and study quality influences the proteinuria benefitDe Boer et al. [57] (2019)RCT: 1,312 adults with type 2 diabetesRandomization to receive vitamin D3 and omega-3 fatty acids and placebo for 5 years, primary outcome: GFR changeNo significant differences in eGFR, urine ACR, or a composite of kidney failure/death between supplement and placebo groups. Adverse events similar across groupsResults do not support use of vitamin D or omega-3 fatty acid supplementationValle Flores et al. [58] (2020)Prospective, randomized, double-blind study in CKD patients undergoing hemodialysisTwo groups: group A (46 patients) received omega-3 fatty acids during 12-week, control group (group B, 47 patients) received paraffin oil, general characteristics, analysis of nutritional indicators, renal disease markers and CRP, IL-6, IL-10, and TNF-alpha evaluatedOmega-3 supplementation produced significant reductions in inflammatory markers and significantly raised the IL-10/IL-6 ratio, while IL-10 increased nonsignificantly; no meaningful changes in the control groupOral omega-3 fatty acid supplementation significantly reduces inflammatory marker concentrations in patients with chronic kidney disease undergoing hemodialysisBunout et al. [59] (2021)RCT: 100 CKD patients supplemented for 3 months with docosahexaenoic and eicosapentaenoic acids or a corn oil supplementEvaluation at baseline, 6 weeks, 12 weeks; variables: blood and morning spot urine samples, blood pressure, carotid intima media thickness, and pulse wave velocity, main outcome: reduction of >/=20% in urine albuminThe n-3 PUFA group showed significant rises in EPA/DHA and omega-3 index and a drop in triglycerides, while both groups had reductions in urine albumin excretion (no significant between-group difference). Pulse wave velocity remained stable with n-3 PUFA but increased in controls; HbA1c rose in both groups and inflammatory markers were unchanged. Secondary analysis revealed systolic blood pressure fall in n-3 PUFA usersOmega-3 fatty acid supplement does not modify urine albumin excretion in patients with CKD but improves pulse wave velocity and serum triglyceride levelsLin et al. [60] (2022)Investigation of oral supplementation with omega-3 PUFA on circulating IL-6, cardiometabolic parameters, skin moisturization, and symptoms of pruritus in hemodialysis patientsTwenty-seven subjects consumed fish oil daily for 3 months and were measured at baseline, first, second, and third month post-supplementationFish oil did not change BMI, serum calcium, phosphorus, or iPTH but significantly reduced pruritus and improved skin hydration. Inflammatory markers (CRP, IL-6), plasma creatinine, and several lipid measures (total cholesterol down, HDL up, TG improved; LDL fell then rose slightly by month three) also improvedOmega-3 PUFA beneficial in hemodialysisAo et al. [61] (2024)24,497 patients with diabetes includedCox proportional hazards regression models used to estimate hazard ratios for CKD risk and impact of fish oilAdjusted analyses found lower CKD risk in diabetic patients who used fish oil and an approximate 2.79-year delay in CKD onset, with stronger effects in men, older adults, non-smokers, and those with healthier diets. Fish oil use also associated with lower HbA1c and CRP and higher HDLFish oil might reduce CKD risk in diabeticsFei et al. [62] (2024)Review and meta-analysis: 9 studies, total of 347 proteinuric participants included in the analysisAnalysis of the impact of omega-3 fatty acid supplementation on proteinuriaSee "Conclusion"Pooled results using fixed- and random-effects models showed non-significant standardized mean differences, with substantial heterogeneity. Study quality was moderate (JADAD 2-4); funnel plot showed no clear publication bias but power was limited by few studies. Overall, omega-3s did not demonstrate a significant anti-proteinuric benefit, though heterogeneity limits confidenceLok et al. [63] (2026)Double-blinded randomized trial of 1,228 adults on maintenance hemodialysisDaily fish-oil supplementation (4 g n-3 fatty acids: 1.6 g EPA + 0.8 g DHA) in comparison with corn-oil placebo over 3.5 yearsFish-oil significantly reduced the rate of serious cardiovascular events (primary end point) vs. placebo and lowered risks of cardiac death, myocardial infarction, stroke, and amputations, with similar adherence and adverse events between groupsFish-oil reduces cardiovascular and mortality risk in hemodialysis patientsDiagnostic and prognostic role of fatty acids and their metabolites in AKIWang et al. [50] (2020)Prospective pilot study: pediatric intensive care, 101 sepsis patients, 30 healthy controlsSerum ApoA5 levels were determined by ELISAApoA5 was lower in septic children than healthy controls and significantly lower in nonsurvivors vs. survivors, correlating with MODS and AKI; low ApoA5 was an independent risk factor for PICU mortality. ROC analysis showed ApoA5 had diagnostic and prognostic value, and it correlated positively with serum calciumLower serum ApoA5 level predicts sepsis-associated complications, e.g., AKI, or MODS in childrenSun et al. [51] (2021)Pilot study: 17 patients with new diagnosed AKI and 17 healthy controlsSerum metabolomic profilingFrom thousands of ion features, 51 reliable metabolites were examined; 1-arachidonoyl-lysoPC was prominent on day 1, while creatine, citrulline, and others distinguished survivors from non-survivors at day 8, with higher levels in those who died. Multimetabolite ROC models predicted outcomes: a 4-metabolite (m4) day-1 model performed best for mortality, an 11-metabolite (m11) day-8 model showed high specificity, and a 3-metabolite (m3) model predicted KRT independence with a favorable AUCDistinct metabolite panels enable assessment of mortality risk in acute kidney injury (AKI)Zhang et al. [53] (2022)Retrospective, observational cohort study: 1,028 patients with primary nephrotic syndrome, AKI (n = 81), non-AKI (n = 947)Examination of serum free fatty acids by enzyme endpoint methodsPrematch, AKI patients were older, more often male, and had more infections, higher SBP, BMI, proteinuria, and serum free fatty acids (FFA), plus lower albumin and HDL. After propensity matching (77 pairs), multivariate analysis found infection, higher SBP, greater proteinuria, and higher FFA associated with AKI No FFA differences by stage or pathological type; FSGS had the highest AKI incidenceSerum FFA showed only weak diagnostic value for AKIin primary nephrotic syndromeZhou et al. [54] (2023)Prospective cohort study: 67 patients with sepsis associated AKI and 20 healthy controlsOxidative lipid analysis in plasma samples, liquid chromatography, tandem mass spectrometric detectionPlasma oxidative lipidomics reveals 21 significantly oxidized lipids. Machine learning (Random Forest, LASSO) highlighted five key biomarkers - particularly 9,10-DiHOME and 5,6-DiHETrE. Pathway analysis showed altered lipid metabolism, including downregulation of vascular smooth muscle contraction and involvement of serotonergic synapse pathwaysIdentification of 9,10-DiHOME and 5,6-DiHETrE as potential biomarkers for detecting sepsis associated AKI, 5-isoPGF2VI: a potential biomarker to distinguish AKI stage III from AKI stages I-II.Zhou et al. [48] (2025)Prospective cohort study in 17 patients with cardiac surgery-associated acute kidney injury (CSA-AKI) and 17 controlsLipidomic analysis through liquid chromatography-mass spectrometry (LC-MS)Broad lipidomic profiling found most differentially expressed lipids were upregulated in CSA-AKI, including acylcarnitines, cholesteryl esters, certain ceramides, lysophosphatidic acids, lysosphingomyelins, PG, and PIP species. Multivariate and network analyses implicated altered glycerophospholipid metabolism and flagged PE(14:0/22:2) and PE(39:1) as early-increased candidates, while PI(18:0/18:1) showed broad negative correlationsIdentification of PE(14:0/22:2) and PE(39:1) as early-increased candidates in CSA-AKIFatty acids, their metabolites and modulators of fatty acid metabolism in AKI managementHoogeveen et al. [64] (2014)2,344 patients with myocardial infarctionRandomization to 4 groups, substitution of eicosapentaenoic acid and docosahexaenoic acid, alpha-linolenic acid, eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid, or placebo for 40 months, eGFR measuredDaily EPA-DHA slows eGFR decline compared with placebo, with a larger benefit in those with baseline CKD. ALA showed no significant effect. EPA-DHA does not significantly reduce the incidence of CKD or rapid kidney-function decline, so effects were modest and variableLong-term supplementation with eicosapentaenoic acid-docosahexaenoic acid associated with small beneficial effects on kidney functionAlrowaie et al. [65] (2021)RCT: 130 patients undergoing coronary angiographyTwo groups: 67 received N-acetylcysteine (NAC), 63 received omega-3 fatty acid before interventionNAC group older with higher prevalence of hyperlipidemia, omega-3 group uses more ACEi/ARBs. Rates of contrast-induced nephropathy, kidney replacement therapy, in-hospital death, MI/stroke, and length of stay significantly not different between treatmentsOmega-3 fatty acids no beneficial effects on contrast-induced nephropathy. CI - (c) The Author(s) 2026. Published by S. Karger AG. LA - eng PT - Published Erratum DEP - 20260930 PL - Switzerland TA - Kidney Blood Press Res JT - Kidney & blood pressure research JID - 9610505 SB - IM EFR - Kidney Blood Press Res. 2026;51(1):567-588. doi: 10.1159/000552568. PMID: 42176287 EDAT- 2026/09/30 17:32 MHDA- 2026/09/30 17:32 CRDT- 2026/09/30 13:28 PHST- 2026/09/30 17:32 [medline] PHST- 2026/09/30 17:32 [pubmed] PHST- 2026/09/30 13:28 [entrez] AID - 000554466 [pii] AID - 10.1159/kbr/adjag008 [doi] PST - ppublish SO - Kidney Blood Press Res. 2026;51(1):915-922. doi: 10.1159/kbr/adjag008. Epub 2026 Sep 30. PMID- 42814221 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261003 IS - 2636-0780 (Electronic) IS - 2636-0772 (Print) IS - 2636-0772 (Linking) VI - 46 IP - 1 DP - 2026 Sep 30 TI - Recent trends in encapsulated bioactives for improving the delivery of infant milk fortifiers. LID - 10.1007/s44463-026-00114-4 [doi] LID - 107 AB - Low birth weight and preterm infants have increased nutritional requirements due to their limited nutrient reserves and physiological immaturity. However, both preterm mother's milk and donor human milk are often deficient in bioactive compounds which are necessary for immune protection, gastrointestinal maturation, and neurodevelopment. Fortifiers are frequently incorporated into human milk to improve its nutritional and functional qualities. This review discusses key bioactive compounds with potential for incorporation into infant milk fortifiers and looks at encapsulating technologies designed to protect bioactives throughout processing and gastrointestinal transit because of the physiological immaturity of preterm newborns. However, the lack of studies on GRAS-approved carriers for infants limits confidence in the applicability of current encapsulation approaches, although some safe encapsulation techniques and carriers have been investigated in infant formulas; data on their use in milk fortifiers remain limited. Encapsulation may be a promising strategy for increasing the efficacy of milk fortifiers. However, this review still identifies existing challenges, including limited clinical validation, safety concerns, and regulatory hurdles, and proposes practical solutions to support the safe and effective clinical application of encapsulated bioactives in neonatal nutrition. CI - (c) 2026. The Author(s). FAU - Latif, Samreen AU - Latif S AUID- ORCID: 0009-0005-8434-0372 AD - Department of Human Nutrition and Dietetics, School of Food and Agricultural Sciences, University of Management and Technology, 54000, Lahore, Pakistan. AD - Nur School of Nutritional Sciences, Nur International University, Lahore, Pakistan. FAU - Naseer, Muhammad Sadiq AU - Naseer MS AD - Nur School of Nutritional Sciences, Nur International University, Lahore, Pakistan. FAU - Khalid, Nauman AU - Khalid N AUID- ORCID: 0000-0002-8045-199X AD - Department of Human Nutrition and Dietetics, School of Food and Agricultural Sciences, University of Management and Technology, 54000, Lahore, Pakistan. nauman.khalid@umt.edu.pk. AD - College of Health Sciences, Abu Dhabi University, 59911, Abu Dhabi, United Arab Emirates. nauman.khalid@umt.edu.pk. FAU - Sarabandi, Khashayar AU - Sarabandi K AD - Research Institute of Food Science and Technology, Mashhad, Islamic Republic of Iran. LA - eng PT - Journal Article PT - Review DEP - 20260930 PL - Switzerland TA - Food Sci Anim Resour JT - Food science of animal resources JID - 101742126 PMC - PMC13627566 OTO - NOTNLM OT - GRAS carriers OT - Gastrointestinal stability OT - Lactoferrin OT - Neonatal nutrition OT - Preterm infants OT - Probiotics COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: As this article is a review paper, ethical approval was not required. EDAT- 2026/09/30 17:32 MHDA- 2026/09/30 17:33 PMCR- 2026/09/30 CRDT- 2026/09/30 11:18 PHST- 2026/04/14 00:00 [received] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/07/14 00:00 [revised] PHST- 2026/09/30 17:33 [medline] PHST- 2026/09/30 17:32 [pubmed] PHST- 2026/09/30 11:18 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - 10.1007/s44463-026-00114-4 [pii] AID - 114 [pii] AID - 10.1007/s44463-026-00114-4 [doi] PST - epublish SO - Food Sci Anim Resour. 2026 Sep 30;46(1):107. doi: 10.1007/s44463-026-00114-4. PMID- 42813573 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1600-0838 (Electronic) IS - 0905-7188 (Print) IS - 0905-7188 (Linking) VI - 36 IP - 10 DP - 2026 Oct TI - One-Year Effects of the FIT FIRST 20 High-Intensity and Multisport Physical Education Program on Physical Fitness and Psychological Outcomes in Early Adolescents: A Cluster-Randomized Controlled Trial. PG - e70374 LID - 10.1111/sms.70374 [doi] LID - e70374 AB - We evaluated the 1-year effectiveness of FIT FIRST 20, a high-intensity multisport physical education (PE) program, on physical fitness and psychological outcomes in 4-6 grade schoolchildren (10-13 years). A cluster-randomized controlled trial was conducted across 82 classes from 30 Danish schools (n = 1652 pupils; 49% girls). Schools were allocated to either three weekly 40-min FIT FIRST 20 sessions (intervention) or standard curriculum PE (control) over approximately 40 weeks. Outcomes were assessed at baseline and post-intervention; 2-year follow-up results will be reported separately. The primary outcome was cardiorespiratory fitness, assessed using the Yo-Yo Intermittent Recovery Test Level 1 (children's version). Secondary outcomes included agility, lower-body muscular power, postural balance, handgrip strength, body composition, blood pressure, resting heart rate, health-related quality of life, physical self-concept, motivation for physical activity, and satisfaction of basic psychological needs. Intervention effects were analyzed using linear mixed-effects models adjusted for sex, baseline sport participation, age, body mass and height. The latter two were excluded from models predicting psychological outcomes. Compared with the control, the intervention arm showed significantly greater improvements in cardiorespiratory fitness (54.90 m, 95% CI [8.35, 101.40], p = 0.021), along with significant gains in agility and lower-body muscular power. No interaction effects were observed for other physical fitness and psychological outcomes, although significant overall effects of time were observed for several outcomes. Overall, FIT FIRST 20 appears to be a feasible school-based strategy for improving selected physical fitness outcomes in 10-13-year-olds. Further modifications may be needed to strengthen the effects on psychological outcomes. Clinical Trial Registration: ISRCTN14624515. CI - (c) 2026 The Author(s). Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd. FAU - Cimenti, Chiara AU - Cimenti C AUID- ORCID: 0009-0002-7302-4911 AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Thogersen-Ntoumani, Cecilie AU - Thogersen-Ntoumani C AUID- ORCID: 0000-0003-0255-1263 AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. FAU - Larsen, Malte Nejst AU - Larsen MN AUID- ORCID: 0000-0002-2600-7126 AD - Sport and Health Sciences Cluster, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Tarantino, Giampiero AU - Tarantino G AUID- ORCID: 0000-0001-9627-883X AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. FAU - Koch, Sofie AU - Koch S AUID- ORCID: 0000-0002-9404-5001 AD - Research Unit for Active Living, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - Research and Implementation Centre for Human Movement and Learning, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Eckert, Caroline AU - Eckert C AUID- ORCID: 0009-0006-3618-7673 AD - Sport and Health Sciences Cluster, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Meiner, Christina Birch AU - Meiner CB AUID- ORCID: 0000-0001-5780-565X AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Prisak, Camilla AU - Prisak C AUID- ORCID: 0009-0006-9289-2721 AD - Sport and Health Sciences Cluster, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Krustrup, Peter AU - Krustrup P AUID- ORCID: 0000-0002-1461-9838 AD - Sport and Health Sciences Cluster, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - Sport and Health Sciences, University of Exeter, Exeter, UK. FAU - Ntoumanis, Nikos AU - Ntoumanis N AUID- ORCID: 0000-0001-7122-3795 AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. AD - School of Education, Language and Psychology, York St. John University, York, UK. LA - eng GR - NNF22SH0077612/Novo Nordisk Fonden/ PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - Denmark TA - Scand J Med Sci Sports JT - Scandinavian journal of medicine & science in sports JID - 9111504 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Blood Pressure MH - Body Composition MH - *Cardiorespiratory Fitness MH - Denmark MH - Exercise MH - Hand Strength MH - Heart Rate MH - Motivation MH - Muscle Strength MH - Personal Satisfaction MH - *Physical Education and Training/methods MH - *Physical Fitness MH - Postural Balance MH - Quality of Life MH - Self Concept PMC - PMC13625196 OTO - NOTNLM OT - adolescents OT - cluster-randomized controlled trial OT - motivation OT - physical education OT - physical fitness COIS- The authors declare no conflicts of interest. EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:36 PMCR- 2026/09/30 CRDT- 2026/09/30 07:24 PHST- 2026/09/16 00:00 [revised] PHST- 2026/01/15 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/09/30 11:36 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 07:24 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - SMS70374 [pii] AID - 10.1111/sms.70374 [doi] PST - ppublish SO - Scand J Med Sci Sports. 2026 Oct;36(10):e70374. doi: 10.1111/sms.70374. PMID- 42813554 OWN - NLM STAT- Publisher LR - 20260930 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) DP - 2026 Sep 30 TI - Beyond the obvious in childhood obesity: exploring cardiac electrophysiological balance index and subclinical risk. PG - 1-6 LID - 10.1017/S1047951126124275 [doi] AB - BACKGROUND: Childhood obesity is associated with adverse cardiovascular outcomes, including increased risk of arrhythmias and subclinical myocardial dysfunction. However, its impact on cardiac electrophysiological balance remains underexplored. The index of cardiac electrophysiological balance, calculated as QT/QRS ratio and corrected form of index of cardiac electrophysiological balance, emerged as novel electrocardiographic markers of ventricular arrhythmia risk. Although these parameters have been investigated in adult populations, data in obese children are lacking. This study aimed to evaluate the effects of obesity on index of cardiac electrophysiological balance and corrected form of index of cardiac electrophysiological balance in children and explore their associations with metabolic and anthropometric measures. METHODS: This retrospective cross-sectional study included 50 obese, 23 healthy children aged 10-18 years. Demographic, metabolic, electrocardiographic, and echocardiographic data were retrieved from hospital records. Index of cardiac electrophysiological balance, corrected form of index of cardiac electrophysiological balance, and repolarisation indices (QTc dispersion, Tp-e dispersion, and P-wave dispersion) were manually measured from 12-lead electrocardiograms. Associations with metabolic and anthropometric parameters were analysed using linear regression. RESULTS: Index of cardiac electrophysiological balance and corrected form of index of cardiac electrophysiological balance values were significantly lower in obese children than in controls (p < 0.001). QTc, Tp-e, and P-wave dispersions were also increased, indicating greater electrical heterogeneity. Index of cardiac electrophysiological balance showed negative correlations with LDL and total cholesterol levels. Tp-e duration and Tp-e/QTc ratio were inversely associated with hip circumference z-scores, possibly reflecting protective effects of gluteofemoral fat distribution. CONCLUSION: Childhood obesity may disrupt cardiac electrophysiological balance and repolarisation, even in the absence of overt cardiovascular disease. Index of cardiac electrophysiological balance and corrected form of index of cardiac electrophysiological balance could serve as early markers of arrhythmia risk. Prospective studies are needed to validate their prognostic significance. FAU - Caglayan Bozlak, Ozlem Hilal AU - Caglayan Bozlak OH AUID- ORCID: 0000-0002-1002-8432 AD - Pediatrics, Marmara Universitesi Egitim ve Arastirma Hastanesi, Turkiye. ROR: https://ror.org/02kswqa67 FAU - Arici, Sule AU - Arici S AD - Pediatric Cardiology, Kartal Kosuyolu High Specialization Training and Research Hospital, Istanbul, Turkiye. FAU - Karagozlu, Selen AU - Karagozlu S AUID- ORCID: 0000-0002-9542-1937 AD - Pediatric Cardiology, Marmara University Department of Pediatric Cardiology, Turkiye. FAU - Akalin, Figen AU - Akalin F AD - Pediatric Cardiology, Marmara University Department of Pediatric Cardiology, Turkiye. LA - eng PT - Journal Article DEP - 20260930 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM OTO - NOTNLM OT - Cardiovascular risk in children OT - cardiac electrophysiological balance index OT - childhood obesity OT - electrocardiography OT - paediatric cardiology OT - subclinical arrhythmia EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:35 CRDT- 2026/09/30 07:15 PHST- 2026/09/30 11:35 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 07:15 [entrez] AID - S1047951126124275 [pii] AID - 10.1017/S1047951126124275 [doi] PST - aheadofprint SO - Cardiol Young. 2026 Sep 30:1-6. doi: 10.1017/S1047951126124275. PMID- 42813541 OWN - NLM STAT- Publisher LR - 20260930 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) DP - 2026 Sep 30 TI - Maximum heart rate prediction in children: are maximal heart rate prediction equations suitable for use in paediatric clinical practice? PG - 1-6 LID - 10.1017/S1047951126124056 [doi] AB - AIMS: Assessment of maximal heart rate is used in clinical practice to determine the degree of beta-blockade during exercise and periods of adrenergic stress. When direct measurement is not possible, indirect methods utilising heart rate prediction equations are commonly used, but their validity in children has been challenged. METHODS: Retrospective data on 109 healthy children (male 63, 58%; mean age 11.00 +/- 3.09) undergoing routine exercise testing were analysed. Measured maximal heart rate was compared with estimates obtained from twenty-two prediction equations. RESULTS: All prediction equations overestimated maximal heart rate in males. In females, two equations underpredicted (Fairbarn and Heinzmann-Filho et al.), whilst the remaining equations overpredicted. The equations that predicted most accurately differed between males (Fairbarn) and females (Whyte (males). The prediction equation used commonly in clinical practice, Fox (220-age), overestimated significantly in males and females (p = < 0.001). A moderate positive correlation with age and maximal heart rate was seen in males only (r = 0.3195, p = 0.0107). CONCLUSIONS: This study shows that adult age regression equations do not accurately predict childhood maximal heart rate as determined by exercise testing. An inability to accurately predict maximal heart rate could have important implications for both childhood exercise prescription and the safe monitoring of pharmacological therapy that limits exertional heart rate response in children with inherited arrhythmic syndromes. In the absence of direct measurement of maximal heart rate, alternative paediatric-specific prediction methods should be developed to ensure appropriate estimation of childhood maximal heart rate. FAU - Renwick, Catherine AU - Renwick C AUID- ORCID: 0000-0003-0193-6137 AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 AD - Institute of Cardiovascular Science, University College London, UK. AD - NIHR, London, UK. ROR: https://ror.org/0187kwz08 FAU - Ogden, Mark AU - Ogden M AUID- ORCID: 0009-0009-3876-7024 AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 FAU - Ramos, Monica AU - Ramos M AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 FAU - Williams, Oliver AU - Williams O AD - Cleveland Clinic London Ltd, UK. FAU - Norrish, Gabrielle AU - Norrish G AD - Institute of Cardiovascular Science, University College London, UK. AD - Inherited Cardiovascular Disease Service, Great Ormond Street Hospital for Children, UK. FAU - Till, Jan AU - Till J AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 FAU - Ware, James AU - Ware J AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 AD - National Heart Lung Institute, Imperial College London, UK. FAU - Kaski, Juan Pablo AU - Kaski JP AUID- ORCID: 0000-0002-0014-9927 AD - Institute of Cardiovascular Science, University College London, UK. AD - Inherited Cardiovascular Disease Service, Great Ormond Street Hospital for Children, UK. LA - eng PT - Journal Article DEP - 20260930 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM OTO - NOTNLM OT - children OT - exercise tolerance testing OT - inherited arrhythmic syndromes OT - maximal heart rate OT - predicted heart rate EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:35 CRDT- 2026/09/30 07:13 PHST- 2026/09/30 11:35 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 07:13 [entrez] AID - S1047951126124056 [pii] AID - 10.1017/S1047951126124056 [doi] PST - aheadofprint SO - Cardiol Young. 2026 Sep 30:1-6. doi: 10.1017/S1047951126124056. PMID- 42812988 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261001 IS - 2090-6560 (Print) IS - 2090-6579 (Electronic) IS - 2090-6579 (Linking) VI - 2026 DP - 2026 TI - Rivaroxaban as Secondary Thromboprophylaxis in Pediatric Patients With Short Bowel Syndrome. PG - 7383741 LID - 10.1155/crh/7383741 [doi] LID - 7383741 AB - Pediatric patients with short bowel syndrome often require long-term parenteral nutrition via a central venous catheter (CVC), which places them at risk for venous thromboembolism (VTE). Our objective was to retrospectively review a single-center use of rivaroxaban in patients with short bowel syndrome (n = 3) to determine if rivaroxaban is viable secondary thromboprophylaxis. One out of three patients developed a new VTE while their prophylactic rivaroxaban was held, one patient developed a gastrointestinal bleed, and one patient completed therapy without an event. Rivaroxaban may be feasible in selected patients with short bowel syndrome with close therapeutic drug level monitoring, but larger studies are needed. CI - Copyright (c) 2026 Angela F. Journell et al. Case Reports in Hematology published by John Wiley & Sons Ltd. FAU - Journell, Angela F AU - Journell AF AD - Intermountain Health, Primary Children's Hospital, Salt Lake City, Utah, USA. FAU - Peters, Chelsea E AU - Peters CE AD - Intermountain Health, Primary Children's Hospital, Salt Lake City, Utah, USA. FAU - Meznarich, Jessica AU - Meznarich J AD - Intermountain Health, Primary Children's Hospital, Salt Lake City, Utah, USA. AD - Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Utah, Salt Lake City, Utah, USA, utah.edu. FAU - Goteti, Sasidhar AU - Goteti S AUID- ORCID: 0000-0002-6510-0577 AD - Intermountain Health, Primary Children's Hospital, Salt Lake City, Utah, USA. AD - Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Utah, Salt Lake City, Utah, USA, utah.edu. LA - eng PT - Journal Article DEP - 20260929 PL - United States TA - Case Rep Hematol JT - Case reports in hematology JID - 101576456 PMC - PMC13621405 OTO - NOTNLM OT - digestive malabsorption OT - rivaroxaban OT - thromboprophylaxis COIS- The authors declare no conflicts of interest. EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:36 PMCR- 2026/09/29 CRDT- 2026/09/30 06:30 PHST- 2026/03/26 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/09/30 11:36 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 06:30 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - CRH7383741 [pii] AID - 10.1155/crh/7383741 [doi] PST - epublish SO - Case Rep Hematol. 2026 Sep 29;2026:7383741. doi: 10.1155/crh/7383741. eCollection 2026. PMID- 42812512 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261001 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 18 DP - 2026 TI - Assessing Vaginal Wall Elasticity via Shear-Wave Elastography Using a Transrectal Linear Array High-Frequency Probe in Premenopausal versus Postmenopausal Women: A Cross-Sectional Feasibility Study. PG - 640465 LID - 10.2147/IJWH.S640465 [doi] LID - 640465 AB - OBJECTIVES: This study aims to evaluate the feasibility of transrectal high-frequency linear array shear wave elastography (SWE) for assessing vaginal wall elasticity in women and to investigate potential differences in segmental elasticity values between premenopausal and postmenopausal populations. METHODS: This cross-sectional study included 228 women (164 premenopausal and 64 postmenopausal) who underwent gynecological ultrasound examinations at Hubei Maternal and Child Health Hospital from December 2024 to January 2025. Transrectal linear array high-frequency ultrasound examinations were performed by two ultrasound technicians. Tissue stiffness was assessed using Young's modulus measurements obtained from six standardized vaginal wall segments: upper, middle, and lower regions of both anterior and posterior walls. Inter-rater reliability was assessed by calculating the intraclass correlation coefficient (ICC). RESULTS: Linear mixed-effects modeling adjusting for age and BMI demonstrated that postmenopausal women exhibited significantly higher Young's modulus values (kPa) in the middle anterior wall (14.59 +/- 3.93 vs 12.88 +/- 3.87 kPa; adjusted P = 0.003, FDR q = 0.009) and middle posterior wall (14.87 +/- 4.09 vs 13.28 +/- 4.25 kPa; adjusted P = 0.013, FDR q = 0.026) compared with premenopausal women. Intra-group analysis revealed a significant proximal-to-distal stiffness gradient along the anterior wall in both premenopausal (P < 0.001) and postmenopausal (P = 0.001) groups, whereas the posterior wall displayed spatial homogeneity (P > 0.10). Inter-observer reliability was excellent, with ICCs ranging from 0.83 (0.68-0.94) to 0.95 (0.88-0.98) (P < 0.001). CONCLUSION: Transrectal SWE is a reliable, non-invasive method for evaluating segment-specific vaginal elasticity. Our study showed that postmenopausal tissue stiffening is localized to the middle vaginal canal rather than pan-vaginal, with an anterior proximal-to-distal elasticity gradient. While these findings advance understanding of regional biomechanical specialization, future large-scale, age-matched, and multicenter studies are required to validate these results and establish clinical diagnostic thresholds. CI - (c) 2026 Wu et al. FAU - Wu, Chunxiao AU - Wu C AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Zhou, Si AU - Zhou S AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Xu, Qianqian AU - Xu Q AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Zhao, Sheng AU - Zhao S AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Yang, Juan AU - Yang J AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Gao, Yanduo AU - Gao Y AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Huang, Cheng AU - Huang C AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Qian, Qingqing AU - Qian Q AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Zhu, Xia AU - Zhu X AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. LA - eng PT - Journal Article DEP - 20260924 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC13620308 OTO - NOTNLM OT - postmenopausal OT - premenopausal OT - transrectal high-frequency linear array OT - vaginal elasticity COIS- The authors report no conflicts of interest in this work. EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:36 PMCR- 2026/09/24 CRDT- 2026/09/30 05:40 PHST- 2026/07/14 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/30 11:36 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 05:40 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - 640465 [pii] AID - 10.2147/IJWH.S640465 [doi] PST - epublish SO - Int J Womens Health. 2026 Sep 24;18:640465. doi: 10.2147/IJWH.S640465. eCollection 2026. PMID- 42812397 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261001 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Low nutrition literacy among 4th-5th graders in Chongqing, China: a wake-up call for school health and factors associated with nutrition literacy. PG - 1903177 LID - 10.3389/fpubh.2026.1903177 [doi] LID - 1903177 AB - OBJECTIVE: Despite growing global recognition that nutrition literacy in childhood is a cornerstone of healthy eating and long-term wellbeing, evidence from Chinese primary school settings-particularly from inland, rapidly urbanizing regions-remains scarce. This study aimed to assess the nutrition literacy level of 4th-5th graders in chongqing, china, and to identify its key influencing factors, thereby sounding a wake-up call for school-based health promotion that holds relevance beyond the local context. METHODS: A multistage stratified cluster sampling method was used to conduct a cross-sectional online survey of 1,420 elementary school students in grades 4 and 5 in Chongqing, China. The questionnaire consisted of three sections: demographic characteristics, dietary behaviors, and nutrition literacy levels (Cronbach's alpha = 0.752). Participants were divided into high- and low-scoring groups based on the median nutritional literacy (NL) score. Multiple linear regression analysis was used to identify factors associated with nutrition literacy scores. RESULTS: The mean nutrition literacy score was 65.47 +/- 9.79. In multivariable analysis, older age, female sex, minority ethnicity, urban residence, and higher caregiver educational attainment were independently associated with higher nutrition literacy scores (all P < 0.05). Keeping meal records (beta = 4.18, 95% CI: 2.84-5.51) and participating in meal preparation (beta = 2.07, 95% CI: 1.03-3.12) were also positively associated with nutrition literacy, whereas a meal duration of 31-45 min was negatively associated with nutrition literacy compared with <15 min (beta = -3.39, 95% CI: -5.36 to -1.42). CONCLUSION: Nutrition literacy among 4th-5th grade students in Chongqing was generally low and was associated with both sociodemographic characteristics and dietary behaviors. The findings highlight the importance of strengthening nutrition education and promoting practical food-related activities among school-aged children, with particular attention to children from socioeconomically disadvantaged backgrounds. CI - Copyright (c) 2026 Lan, Deng, Zhou, Luo, Zhang, Ran, Liu, Shi and Zhao. FAU - Lan, Yuanyuan AU - Lan Y AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Deng, Jiaxin AU - Deng J AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Zhou, Ailin AU - Zhou A AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Luo, Yaocheng AU - Luo Y AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Zhang, Huiyi AU - Zhang H AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Ran, Wenhua AU - Ran W AD - Yuzhong District Primary and Middle School Health Care Center, Chongqing, China. FAU - Liu, Ling AU - Liu L AD - Yuzhong District Primary and Middle School Health Care Center, Chongqing, China. FAU - Shi, Zumin AU - Shi Z AD - Department of Nutrition Sciences, College of Health Sciences, Qatar University, Doha, Qatar. FAU - Zhao, Yong AU - Zhao Y AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. AD - Chongqing Key Laboratory of Child Nutrition and Health, Children's Hospital of Chongqing Medical University, Chongqing, China. LA - eng PT - Journal Article DEP - 20260915 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - China MH - Male MH - Child MH - Cross-Sectional Studies MH - *Health Literacy/statistics & numerical data MH - Surveys and Questionnaires MH - *Students/statistics & numerical data MH - Schools MH - Health Knowledge, Attitudes, Practice PMC - PMC13619951 OTO - NOTNLM OT - health OT - nutrition education OT - nutrition knowledge OT - nutrition literacy OT - school-age children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:36 PMCR- 2026/09/15 CRDT- 2026/09/30 05:23 PHST- 2026/06/08 00:00 [received] PHST- 2026/08/18 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/30 11:36 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 05:23 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1903177 [doi] PST - epublish SO - Front Public Health. 2026 Sep 15;14:1903177. doi: 10.3389/fpubh.2026.1903177. eCollection 2026. PMID- 42812226 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261001 IS - 2235-2988 (Electronic) IS - 2235-2988 (Linking) VI - 16 DP - 2026 TI - Dynamics of virological suppression and systemic immune-inflammatory response following antiretroviral therapy in pediatric HIV infection. PG - 1918829 LID - 10.3389/fcimb.2026.1918829 [doi] LID - 1918829 AB - BACKGROUND: Persistent systemic inflammation remains a hallmark of treated HIV infection and is not reliably resolved by virological suppression alone. The Systemic Immune-Inflammation Index (SII), a composite hematologic index [(neutrophil x platelet)/lymphocyte count], has emerged as a candidate inflammatory biomarker. Longitudinal SII data following antiretroviral therapy (ART) initiation in pediatric HIV are lacking. METHODS: This single-center retrospective paired longitudinal study included 30 pediatric patients with HIV with laboratory data at baseline and 12 months post-ART. The primary outcome was change in SII; secondary outcomes included CD4%, HIV RNA, and double-negative T-cell percentage (DNT%). Non-improvers were characterized by age, sex, ART regimen, nutritional status, and co-infection status. Paired comparisons used the Wilcoxon signed-rank test; Spearman correlation was the primary inferential method, with Pearson as a sensitivity analysis. RESULTS: Median SII declined numerically (342,637 to 250,527) but did not reach significance (p = 0.428), despite significant improvement in CD4% (p < 0.001) and HIV RNA (p < 0.001). SII failed to improve in 13/30 patients (43.3%). The baseline inverse correlation between SII and CD4% (r = -0.450, p = 0.013) was substantially attenuated at month 12 (r = -0.004, p = 0.985). A parametric correlation between DeltaSII and DeltaHIV RNA (r = +0.534, p = 0.002) was not confirmed on rank-based testing (rho = +0.004), reflecting leverage from two extreme-viremia patients. The 1-2-year age group had the highest rate of SII non-improvement (75.0%); an unadjusted post-hoc comparison with the 6-11-year group yielded a nominal p value of 0.038. Female sex was more frequent among non-improvers (53.8% vs. 17.6%; p = 0.056), although the difference was not statistically significant. Genvoya((R)) use showed a similar non-significant trend (p = 0.132). Nutritional status, herpesvirus co-infection, and virological suppression at month 12 were not significantly associated with SII trajectory. CONCLUSION: In this pediatric HIV cohort, SII failed to improve in nearly half of patients despite successful ART, dissociating from both CD4 reconstitution and HIV RNA suppression. These findings suggest SII reflects a residual inflammatory state driven by mechanisms beyond viral replication, including ART class-specific, sex-related, and developmental factors. Routine SII monitoring may identify patients at ongoing inflammatory risk despite virological success; larger prospective studies are needed. CI - Copyright (c) 2026 Usaklioglu Erol, Kacmaz, Somer and Hancerli Torun. FAU - Usaklioglu Erol, Mavera AU - Usaklioglu Erol M AD - Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkiye. AD - Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Health Sciences Turkiye, Istanbul Training and Research Hospital, Istanbul, Turkiye. FAU - Kacmaz, Behiye Benaygul AU - Kacmaz BB AD - Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkiye. FAU - Somer, Ayper AU - Somer A AD - Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkiye. FAU - Hancerli Torun, Selda AU - Hancerli Torun S AD - Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260915 PL - Switzerland TA - Front Cell Infect Microbiol JT - Frontiers in cellular and infection microbiology JID - 101585359 RN - 0 (RNA, Viral) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *HIV Infections/drug therapy/immunology/virology MH - Female MH - Male MH - Child MH - Retrospective Studies MH - Longitudinal Studies MH - Viral Load/drug effects MH - *Inflammation/immunology MH - Child, Preschool MH - RNA, Viral/blood MH - Adolescent MH - CD4 Lymphocyte Count MH - Antiretroviral Therapy, Highly Active MH - Biomarkers MH - Treatment Outcome MH - Infant PMC - PMC13619414 OTO - NOTNLM OT - CD4 OT - CD4/CD8 OT - HIV OT - antiretroviral therapy OT - immune activation OT - inflammation OT - pediatric OT - systemic immune-inflammation index (SII) COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/30 05:30 MHDA- 2026/09/30 12:25 PMCR- 2026/09/15 CRDT- 2026/09/30 04:51 PHST- 2026/06/24 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/30 12:25 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/30 04:51 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - 10.3389/fcimb.2026.1918829 [doi] PST - epublish SO - Front Cell Infect Microbiol. 2026 Sep 15;16:1918829. doi: 10.3389/fcimb.2026.1918829. eCollection 2026. PMID- 42812133 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261007 IS - 1839-2628 (Electronic) IS - 1832-4274 (Linking) VI - 29 IP - 4 DP - 2026 Aug TI - Neonatal Health and Long-Term Outcomes: Twin-Based Evidence From Linked Scandinavian Registers. PG - 323-333 LID - 10.1017/thg.2026.10095 [doi] AB - This study examines the long-term consequences of neonatal health using three birth anthropometric measures - weight, length, and head circumference - and analyzes their differential associations with outcomes across the life course. Using linked Swedish and Norwegian population registers with follow-up into adulthood, we compare birth measures of singletons and twins and further estimate within-twin-pair fixed-effects models that control for shared genetic and family environmental factors. Our samples comprise up to approximately 679,000 singletons and 10,400 twins in Sweden, and 347,841 singletons and 6,762 twins in Norway, followed into adulthood. We find that different birth measures capture distinct aspects of fetal development with varying predictive validity across outcome domains. Birth length emerges as the strongest predictor of health outcomes (infant mortality, adult height), consistent with its role as a cumulative indicator of skeletal growth throughout gestation. Birth weight retains stronger associations with cognitive and educational outcomes (grade point average [GPA], years of schooling) in conditional models. Head circumference shows weak and inconsistent associations across specifications. Using within-pair head circumference differences to classify twins as symmetrically versus asymmetrically growth restricted, we find that symmetric intrauterine growth restriction is associated with substantially worse long-term outcomes than asymmetric restriction. In Norwegian twin pairs, growth restriction is associated with lower general cognitive ability (measured at military enlistment) relative to the unaffected co-twin; this within-pair deficit is more than twice as large for symmetric as for asymmetric restriction. We also document significant intergenerational transmission of birth anthropometrics, suggesting both environmental and genetic contributions. Finally, our register-based design with near-complete population coverage minimizes selection bias and attrition while providing statistical power for within-pair analyses across multiple outcomes. Exclusive reliance on birth weight may obscure important information about early-gestation developmental insults. FAU - Conti, Gabriella AU - Conti G AUID- ORCID: 0000-0003-4699-2490 AD - NHH, Norway. FAU - Buetikofer, Aline AU - Buetikofer A AD - Department of Economics and Social Research Institute, University College London, UK. FAU - Bjorkegren, Evelina AU - Bjorkegren E AD - Stockholm University, Sweden. FAU - Palme, Marten AU - Palme M AD - Stockholm University, Sweden. FAU - Salvanes, Kjell G AU - Salvanes KG AD - Department of Economics and Social Research Institute, University College London, UK. LA - eng PT - Journal Article PT - Twin Study PL - England TA - Twin Res Hum Genet JT - Twin research and human genetics : the official journal of the International Society for Twin Studies JID - 101244624 SB - IM MH - Humans MH - Female MH - *Registries MH - *Birth Weight MH - Infant, Newborn MH - Norway/epidemiology MH - Male MH - Adult MH - Sweden/epidemiology MH - *Infant Mortality MH - *Fetal Development MH - *Twins/genetics MH - Infant MH - Body Height MH - *Twins, Dizygotic/genetics OTO - NOTNLM OT - Birth length OT - Birth weight OT - Fetal origins OT - Head circumference OT - Intrauterine growth restriction OT - Linkage to administrative data OT - Twin studies EDAT- 2026/09/30 05:30 MHDA- 2026/10/06 11:31 CRDT- 2026/09/30 04:24 PHST- 2026/10/06 11:31 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/30 04:24 [entrez] AID - S1832427426100954 [pii] AID - 10.1017/thg.2026.10095 [doi] PST - ppublish SO - Twin Res Hum Genet. 2026 Aug;29(4):323-333. doi: 10.1017/thg.2026.10095. PMID- 42812016 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261012 IS - 1576-6578 (Electronic) IS - 0210-0010 (Print) IS - 0210-0010 (Linking) VI - 81 IP - 9 DP - 2026 Sep 23 TI - Consensus for the Diagnosis and Treatment of Patients With Spinal Muscular Atrophy (SMA) in Latin America. PG - 53782 LID - 10.31083/RN53782 [doi] LID - 53782 AB - BACKGROUND: 5q spinal muscular atrophy (5q SMA) is an autosomal recessive neuromuscular disorder caused by mutations in the survival motor neuron 1 gene (SMN1), leading to deficiency of SMN protein and a variable clinical spectrum influenced by survival motor neuron 2 gene (SMN2) copy number. The advent of disease-modifying therapies (DMTs) has transformed its clinical course, requiring timely diagnosis, multidisciplinary care, and longitudinal response assessment. In Latin America (LATAM), significant gaps and heterogeneity persist in access to genetic diagnosis, newborn screening, DMTs, and specialized follow-up. To develop a Latin American consensus providing recommendations for diagnosis, comprehensive management (respiratory, swallowing/nutrition, rehabilitation, and DMTs), and evaluation of response to DMTs in patients with SMA, incorporating real-world access considerations. METHODS: A regional expert panel conducted a formal consensus process (2025-2026) through iterative questionnaires and structured discussions. Agreement was defined as >/=70% concordance. Additionally, a regional survey assessed access to diagnostic and therapeutic resources. RESULTS: Forty professionals from 15 countries participated. While 90% reported access to genetic testing (MLPA), only 35% indicated availability within the public healthcare system; private access and pharmaceutical industry support were also reported as pathways to testing. No participating country reported nationwide implementation of newborn screening for SMA; 22.5% of respondents reported pilot programs or future implementation proposals. Access to at least one DMT was reported by 92.5% of respondents; however, delays between diagnosis and treatment initiation were frequent and remain an important challenge across the region. Consensus recommendations were established for diagnosis, functionally stratified multidisciplinary care, and response assessment based on motor and non-motor domains using validated tools and individualized follow-up. CONCLUSIONS: This consensus provides a practical and adaptable framework to optimize SMA care in LATAM, supporting longitudinal, patient-centered clinical decision-making. CI - Copyright: (c) 2026 The Author(s). Published by IMR Press. FAU - Nascimento Osorio, Andres E AU - Nascimento Osorio AE AD - Unidad de Neuromuscular, Hospital Sant Joan de Deu; Group of Applied Research in Neuromuscular Diseases, Institut de Recerca Sant Joan de Deu, 08950 Barcelona, Espana. AD - Center for the Biomedical Research on Rare Diseases (CIBERER), ISCIII, 08036 Barcelona, Espana. FAU - Barros Acevedo, Graciela AU - Barros Acevedo G AD - Centro Hospitalario Pereira Rossell, Instituto de Neurologia, 11600 Montevideo, Uruguay. AD - Teleton Uruguay, 11600 Montevideo, Uruguay. FAU - Beytia, Maria de Los Angeles AU - Beytia MLA AD - Seccion de Neurologia Pediatrica, Division de Pediatria, Escuela de Medicina, Pontificia Universidad Catolica de Chile, 8331150 Santiago, Chile. AD - Unidad de Neurologia Pediatrica, Servicio de Pediatria, Hospital Dr. Sotero del Rio, 8150215 Santiago, Chile. FAU - Bobadilla Quesada, Edna J AU - Bobadilla Quesada EJ AD - Departamento de Pediatria, Fundacion Hospital de la Misericordia (HOMI), 111411 Bogota, Colombia. AD - Hospital Universitario San Ignacio, 110231 Bogota, Colombia. FAU - Castellar-Leones, Sandra M AU - Castellar-Leones SM AD - Departamento de Pediatria, Fundacion Hospital de la Misericordia (HOMI), 111411 Bogota, Colombia. AD - Departamento de Medicina Fisica y Rehabilitacion, Facultad de Medicina, Universidad Nacional de Colombia, 111321 Bogota, Colombia. AD - Hospital Universitario Nacional de Colombia, 111321 Bogota, Colombia. FAU - Castiglioni, Claudia AU - Castiglioni C AD - Departamento de Pediatria, Clinica MEDS, 7510155 Santiago, Chile. AD - Escuela de Medicina, Universidad Finis Terrae, 7501015 Santiago, Chile. FAU - Casartelli Galeano, Marco J AU - Casartelli Galeano MJ AD - Hospital General Pediatrico Ninos de Acosta Nu, Ministerio de Salud Publica y Bienestar Social, 2160 San Lorenzo, Paraguay. FAU - Contreras Caicedo, Guilca AU - Contreras Caicedo G AD - Servicio de Neuropediatria, Centro Medico Docente La Trinidad, 1080 Caracas, Venezuela. FAU - Cordero Molina, Maria Fernanda AU - Cordero Molina MF AD - Neurologia Infantil, Clinica Monte Sinai, 010107 Cuenca, Ecuador. AD - Clinica Latinoamericana, 010107 Cuenca, Ecuador. FAU - Escobar Cedillo, Rosa E AU - Escobar Cedillo RE AD - Instituto Nacional de Rehabilitacion "Luis Guillermo Ibarra Ibarra" (INR-LGII), 14389 Ciudad de Mexico, Mexico. FAU - Espinel, Francisco AU - Espinel F AD - Unidad de Neurologia Pediatrica, Servicio de Pediatria, Hospital Metropolitano, 170135 Quito, Ecuador. FAU - Earle, Nicholas AU - Earle N AD - Departamento de Neurologia y Neurocirugia, Clinica Davila, Santiago, Chile, and Corporacion de Investigacion de Neurologia de Santiago (CINSAN), 8431657 Santiago, Chile. FAU - Franco Tonanez, Carlos A AU - Franco Tonanez CA AD - Departamento de Neuropediatria, Hospital General Pediatrico Ninos de Acosta Nu, 2160 San Lorenzo, Paraguay. FAU - Galvez Quinonez, Henry H AU - Galvez Quinonez HH AD - Centro GALO, 01015 Ciudad de Guatemala, Guatemala. AD - Hospital Regional de Occidente HRO, 09001 Ciudad de Guatemala, Guatemala. FAU - Gurgel-Giannetti, Juliana AU - Gurgel-Giannetti J AD - Department of Pediatrics, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), 30130-100 Belo Horizonte, Brazil. FAU - Gutierrez Mata, Alfonso P AU - Gutierrez Mata AP AD - Hospital Nacional de Ninos de Costa Rica "Dr. Carlos Saenz Herrera", 10101 San Jose, Costa Rica. FAU - Hervias Ruz, Maria C AU - Hervias Ruz MC AD - Neurologia Infantil, Clinica MEDS, 7510155 Santiago, Chile. AD - Escuela de Kinesiologia, Facultad de Medicina, Universidad de los Andes, 7620001 Santiago, Chile. FAU - Linzoain, Javier E AU - Linzoain JE AD - Servicio de Neurologia Pediatrica, Clinica Universitaria Reina Fabiola, X5000 Cordoba, Argentina. AD - Hospital Infantil Municipal de la Ciudad de Cordoba, X5000 Cordoba, Argentina. FAU - Lucero, Mariela A AU - Lucero MA AD - Servicio de Neurologia Infantil, Hospital de Ninos Sor Maria Ludovica, 1900 La Plata, Buenos Aires, Argentina. FAU - Medici, Conrado AU - Medici C AD - Centro Hospitalario Pereira Rossell, Instituto de Neurologia, 11600 Montevideo, Uruguay. FAU - Mesa Restrepo, Sandra C AU - Mesa Restrepo SC AD - Hospital Pablo Tobon Uribe, 050031 Medellin, Colombia. FAU - Meza Cano, Maria E AU - Meza Cano ME AD - Hospital CHRISTUS MUGUERZA Alta Especialidad, 64060 Monterrey, Mexico. AD - Instituto Tecnologico de Monterrey, 64849 Monterrey, Mexico. FAU - Monges, Soledad AU - Monges S AD - Servicio de Neurologia, Hospital de Pediatria S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", 1245 Buenos Aires, Argentina. FAU - Munive Baez, Leticia M AU - Munive Baez LM AD - Servicio de Neurologia, Hospital Medica Sur, 14050 Ciudad de Mexico, Mexico. AD - Instituto Nacional de Pediatria, 04530 Ciudad de Mexico, Mexico. FAU - Nunez Antelo, Lourdes I AU - Nunez Antelo LI AD - VITAE Medicina y Diagnostico, 10260 Santa Cruz de la Sierra, Bolivia. AD - Caja Petrolera de Salud, 10260 Santa Cruz de la Sierra, Bolivia. FAU - Odales Ibarra, Rogelio R AU - Odales Ibarra RR AD - Hospital Pediatrico Baca Ortiz, 170136 Quito, Ecuador. AD - Universidad de las Americas (UDLA), 170125 Quito, Ecuador. FAU - Artiga-Rodriguez, Veronica D AU - Artiga-Rodriguez VD AD - Servicio de Neuropediatria, Hospital Nacional de Ninos Benjamin Bloom, 1101 San Salvador, El Salvador. AD - Clinica Neuroplastickids, 1101 San Salvador, El Salvador. FAU - Perez Almengor, Eva S AU - Perez Almengor ES AD - Hospital del Nino, Dr. Jose Renan Esquivel, 0816-02189 Ciudad de Panama, Panama. FAU - Martinez Esteban, Peggy C AU - Martinez Esteban PC AD - Instituto Nacional de Salud del Nino San Borja, 15036 Lima, Peru. FAU - Ramirez-Montano, Diana AU - Ramirez-Montano D AD - Unidad de Medicina Genomica y Genetica, Clinica Imbanaco Grupo Quiron Salud, 760042 Cali, Colombia. AD - Departamento de Morfologia, Facultad de Salud, Universidad del Valle; Hospital Universitario del Valle Evaristo Garcia ESE, 760032 Cali, Colombia. FAU - Moreno-Salgado, Rodrigo AU - Moreno-Salgado R AD - Fundacion Padrino Todos Santos A.C., 23300 Todos Santos, Baja California Sur, Mexico. FAU - Ruiz Garcia, Matilde AU - Ruiz Garcia M AD - Instituto Nacional de Pediatria, 04530 Ciudad de Mexico, Mexico. FAU - Saez Galaz, Veronica AU - Saez Galaz V AD - Servicio de Neuropsiquiatria Infantil, Hospital Clinico San Borja Arriaran, 8320000 Santiago, Chile. AD - Clinica Universidad de los Andes, 7620001 Santiago, Chile. FAU - Vargas Canas, Edwin S AU - Vargas Canas ES AD - Clinica de Enfermedades Neuromusculares, Instituto Nacional de Neurologia y Neurocirugia "Manuel Velasco Suarez", 14269 Ciudad de Mexico, Mexico. AD - Centro de Neurociencias, Hospital Angeles del Pedregal, 01900 Ciudad de Mexico, Mexico. FAU - Bevilacqua, Jorge A AU - Bevilacqua JA AD - Departamento de Neurologia y Neurocirugia, Clinica Davila, Santiago, Chile, and Corporacion de Investigacion de Neurologia de Santiago (CINSAN), 8431657 Santiago, Chile. AD - Departamento de Neurologia y Neurocirugia, Hospital Clinico Universidad de Chile & Departamento de Anatomia y Medicina Legal, Facultad de Medicina, Universidad de Chile, 8380453 Santiago, Chile. FAU - Zanoteli, Edmar AU - Zanoteli E AD - Department of Neurology, Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), 01246-903 Sao Paulo, Brazil. FAU - Zuniga Garcia, Carol J AU - Zuniga Garcia CJ AD - Hospital Mario Catarino Rivas, Servicio de Neurologia Pediatrica, 21104 San Pedro Sula, Cortes, Honduras. AD - Hospital del Valle, 21102 San Pedro Sula, Cortes, Honduras. FAU - Guecaimburu, Maria R AU - Guecaimburu MR AD - Equipo de Enfermedades Raras, CRENADECER, BPS, 11200 Montevideo, Uruguay. FAU - Gutierrez-Saenz, Mario AU - Gutierrez-Saenz M AD - Neurologia, Hospital Clinica Biblica, 10101 San Jose de Costa Rica, Costa Rica. AD - Caja Costarricense del Seguro Social, 10104 San Jose de Costa Rica, Costa Rica. FAU - Armijo Gomez, Jesus A AU - Armijo Gomez JA AD - Hospital General con Especialidades Juan Maria Salvatierra, 23000 La Paz, Mexico. AD - Neurologia Pediatrica & Patologia Neuromuscular, 23000 La Paz, Mexico. LA - eng LA - spa GR - Roche and Novartis/ PT - Consensus Statement PT - Journal Article TT - Consenso para el Diagnostico y Tratamiento para Pacientes con Atrofia Muscular Espinal (AME) en America Latina. PL - Singapore TA - Rev Neurol JT - Revista de neurologia JID - 7706841 SB - IM MH - Humans MH - Latin America MH - *Muscular Atrophy, Spinal/diagnosis/therapy/genetics MH - Neonatal Screening MH - Genetic Testing PMC - PMC13653183 OTO - NOTNLM OT - Latin America OT - consensus OT - genetic therapy OT - neonatal screening OT - nusinersen OT - risdiplam OT - spinal muscular atrophies of childhood OT - spinal muscular atrophy OT - survival motor neuron 1 gene (SMN1) OT - survival motor neuron 2 gene (SMN2) COIS- Graciela Barros Acevedo, Rogelio R. Odales Ibarra, Maria R. Guecaimburu, Veronica D. Artiga-Rodriguez, Lourdes I. Nunez Antelo, Conrado Medici, Matilde Ruiz Garcia, Carol J. Zuniga Garcia, Maria C. Hervias Ruz, Alfonso P. Gutierrez Mata, Eva S. Perez Almengor, Rosa E. Escobar Cedillo, Maria F. Cordero Molina, Henry H. Galvez Quinonez, Maria de los Angeles Beytia, Maria E. Meza Cano, Carlos A. Franco Tonanez, Guilca Contreras Caicedo, Rodrigo Moreno-Salgado, Veronica Saez Galaz, Edwin S. Vargas Canas, Mario Gutierrez-Saenz, Francisco Espinel, and Nicholas Earle declare that they have no conflicts of interest. EDAT- 2026/09/30 05:30 MHDA- 2026/09/30 05:31 PMCR- 2026/09/23 CRDT- 2026/09/30 04:03 PHST- 2026/05/12 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/30 05:31 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/30 04:03 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - S0210-0010(26)00140-4 [pii] AID - 10.31083/RN53782 [doi] PST - ppublish SO - Rev Neurol. 2026 Sep 23;81(9):53782. doi: 10.31083/RN53782. PMID- 42811307 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261006 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Aug 10 TI - Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert((R))MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries. LID - 10.1186/s12879-026-13902-6 [doi] LID - 1736 AB - INTRODUCTION: Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organization (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRDs) with stool as an initial diagnostic tool for paediatric TB. In this study, we evaluated the diagnostic test accuracy (DTA) of stool samples processed with the Stool Processing Kit (SPK), one of three centrifugation-free methods available at the time. METHODS: We conducted a multi-centre prospective diagnostic validation study in South Africa, Tanzania, Malawi, Mozambique, and India. Children (< 15 years) under investigation for TB provided at least two (induced) sputum samples at enrolment, one stool sample, and one nasopharyngeal aspirate (NPA) if aged < 5 years and a chest x-ray. TB testing included Xpert((R)) MTB/RIF Ultra (Ultra) and culture. Diagnostic classification followed NIH consensus statements. Stool samples were processed using the SPK and tested with Ultra. We calculated DTA in the overall cohort and predefined subgroups of interest. RESULTS: Out of 5313 children screened, 975 were enrolled, and data from 817 children recruited between January 2019 and June 2021 were analysed. The overall microbiological confirmation rate was 203/817 (24.9%), and an additional 358/817 (43.8%) were classified as unconfirmed TB and 256/817 (31.3%) were classified as unlikely TB. The median age was 5.3 years (IQR: 2.0-9.2), and 390/817 (47.7%) of participants were under the age of five. 134/817 (16.4%) of children were living with HIV, and 88/817 (10.8%) had severe acute malnutrition (SAM). The overall sensitivity and specificity of SPK/Ultra against a Strict Reference Standard (SRS) were 33.8% (95% CI: 27.6-40.6) and 86.8% (95% CI: 80.5-91.3), respectively. Among children under one year of age and those with SAM, sensitivity was 43.3% (95% CI: 27.4-60.8) and 41.4% (95% CI: 25.5-59.3), respectively, with specificity reaching 100% in young children and 85% (95% CI: 64.0-94.8) in children with SAM. Classic TB symptoms and chest X-ray abnormalities at baseline were associated with increased likelihood of SPK/Ultra positivity. CONCLUSIONS: This is one of the largest studies to evaluate stool as an alternative specimen for diagnosing paediatric TB. Although the WHO's target product profile was not fully met, stool testing with SPK/Ultra represents a viable alternative to invasive sampling methods, especially in subgroups of interest. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03734172, June 22, 2018. CI - (c) 2026. The Author(s). FAU - Banze, Denise AU - Banze D AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. denise.banze@ins.gov.mz. AD - CIH LMU Center for International Health, University Hospital, LMU Munich, Munich, Germany. denise.banze@ins.gov.mz. FAU - Olbrich, Laura AU - Olbrich L AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany. FAU - Razid, Alia AU - Razid A AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Pettenkofer School of Public Health, Munich, Germany. FAU - Franckling-Smith, Zoe AU - Franckling-Smith Z AD - Department of Paediatrics & Child Health, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Mfinanga, Alfred AU - Mfinanga A AD - CIH LMU Center for International Health, University Hospital, LMU Munich, Munich, Germany. AD - National Institute for Medical Research - Mbeya Medical Research Centre, Mbeya, Tanzania. FAU - Ntinginya, Nyanda Elias AU - Ntinginya NE AD - National Institute for Medical Research - Mbeya Medical Research Centre, Mbeya, Tanzania. FAU - Sabi, Issa AU - Sabi I AD - National Institute for Medical Research - Mbeya Medical Research Centre, Mbeya, Tanzania. AD - Department of Paediatric and Child Health, School of Medicine and Dentistry, University of Dodoma, Dodoma, Tanzania. FAU - Nliwasa, Marriot AU - Nliwasa M AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. FAU - Semphere, Robina AU - Semphere R AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. FAU - Corbett, Elizabeth L AU - Corbett EL AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. AD - TB Center, London School of Hygiene and Tropical Medicine, London, UK. FAU - Michael, Joy Sarojini AU - Michael JS AD - Clinical Microbiology, Christian Medical College, Vellore, India. FAU - Verghese, Valsan Philip AU - Verghese VP AD - Pediatric Infectious Diseases, Christian Medical College, Vellore, India. FAU - Graham, Stephen M AU - Graham SM AD - Department of Paediatrics and Department of Respiratory Medicine, Royal Children's Hospital, University of Melbourne, Melbourne, Australia. FAU - Nabeta, Pamela AU - Nabeta P AD - Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland. FAU - Trollip, Andre AU - Trollip A AD - Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland. FAU - Song, Rinn AU - Song R AD - Oxford Vaccine Group, Department of Paediatrics, and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. FAU - Larsson, Leyla AU - Larsson L AD - Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK. FAU - Geldmacher, Christof AU - Geldmacher C AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Hoelscher, Michael AU - Hoelscher M AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Zar, Heather J AU - Zar HJ AD - Department of Paediatrics & Child Health, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Viegas, Sofia AU - Viegas S AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. FAU - Heinrich, Norbert AU - Heinrich N AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany. FAU - Khosa, Celso AU - Khosa C AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. AD - Department of International Public Health and Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. AD - Universidade Eduardo Mondlane, Maputo, Mozambique. LA - eng SI - ClinicalTrials.gov/NCT03734172 GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ PT - Clinical Trial PT - Journal Article PT - Multicenter Study DEP - 20260810 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Feces/microbiology MH - India MH - Malawi MH - *Molecular Diagnostic Techniques/methods MH - Mozambique MH - Mycobacterium tuberculosis/isolation & purification/genetics MH - Prospective Studies MH - Rapid Diagnostic Tests MH - Sensitivity and Specificity MH - South Africa MH - *Specimen Handling/methods MH - Sputum/microbiology MH - Tanzania MH - *Tuberculosis/diagnosis/microbiology MH - *Developing Countries PMC - PMC13621693 OTO - NOTNLM OT - Child* OT - Diagnostics OT - Stool OT - Tuberculosis OT - mWRDs COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Committee of the Faculty of Medicine at Ludwig-Maximilians-University Munich, Germany; the University of Cape Town, Faculty of Health Sciences, Human Research Ethics Committee, South Africa; the Mbeya Medical Research and Ethics Committee, Tanzania; the Ministerio da Saude, Comite Nacional de Bioetica para a Saude, Mozambique; the College of Medicine Research and Ethics Committee (COMREC), Malawi; and the Office of Research Institutional Review Board, Christian Medical College, Vellore, India. The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from caregivers or legal guardians of all participants, and assent was obtained from children in accordance with local ethical guidelines. Consent for publication: Consent for publication: Not applicable. This manuscript does not include any individual person's data in an identifiable form (including images). All data are presented in aggregate and/or de-identified. Competing interests: All authors have received funding from the European & Developing Countries Clinical Trials Partnership (EDCTP) to their respective institutions. Cepheid provided testing kits at no cost. EDAT- 2026/09/30 05:30 MHDA- 2026/09/30 05:31 PMCR- 2026/08/10 CRDT- 2026/09/29 23:53 PHST- 2025/12/26 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/09/30 05:31 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/29 23:53 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.1186/s12879-026-13902-6 [pii] AID - 13902 [pii] AID - 10.1186/s12879-026-13902-6 [doi] PST - epublish SO - BMC Infect Dis. 2026 Aug 10;26(1):1736. doi: 10.1186/s12879-026-13902-6. PMID- 42810158 OWN - NLM STAT- Publisher LR - 20260929 IS - 1873-5487 (Electronic) IS - 0188-4409 (Linking) VI - 58 IP - 1 DP - 2026 Sep 29 TI - Strengthening the Socio-cultural Dimension of Food in the Mexican Healthy and Sustainable Dietary Guidelines. PG - 103531 LID - S0188-4409(26)00153-0 [pii] LID - 10.1016/j.arcmed.2026.103531 [doi] AB - BACKGROUND: Dietary guidelines should incorporate not only advances in nutritional science but also the sociocultural factors that shape food practices. This study describes how the sociocultural dimension was integrated into the 2023 Mexican Healthy and Sustainable Dietary Guidelines (HSDGs). It presents key formative research findings on food practices, perceptions, and the sociocultural and environmental factors influencing adherence to selected dietary recommendations, which informed the contextualization, formulation, and communication of the Guidelines. METHODS: We conducted 84 semi-structured interviews with mothers and fathers of children and adolescents from low socioeconomic households across Mexico. Interviews explored food practices, the sociocultural food space, the feasibility of adopting selected dietary recommendations, and environmental practices related to food consumption. RESULTS: Social norms, symbolic meanings, gendered food responsibilities, and food environment factors strongly influenced dietary practices. Prevailing norms encouraged the consumption of red meat and ultra-processed products while discouraging vegetables and legumes, creating barriers to healthier and more sustainable diets. CONCLUSIONS: These findings informed recommendations to reshape food-related social norms by promoting vegetables and legumes as everyday foods, challenging the normalization of frequent red meat and ultra-processed product consumption, encouraging shared household food responsibilities, and addressing structural barriers such as the seasonal affordability of fruits and vegetables. CI - Copyright (c) 2026 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved. FAU - Theodore, Florence L AU - Theodore FL AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Pacheco-Miranda, Selene AU - Pacheco-Miranda S AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Venosa-Lopez, Monica AU - Venosa-Lopez M AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Franco-Salazar, Mariel Andrea AU - Franco-Salazar MA AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Gaxiola, Ana Cecilia AU - Gaxiola AC AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Molina-Barrera, Veronika AU - Molina-Barrera V AD - Consultant to the UN Food and Agriculture Organization. FAU - Brero, Mauro AU - Brero M AD - Consultant for Food and Agriculture Organization of the United Nations Head of Nutrition at the United Nations Children's Fund. FAU - Bonvecchio, Anabelle AU - Bonvecchio A AD - Consultant for Food and Agriculture Organization of the United Nations Head of Nutrition at the United Nations Children's Fund. Electronic address: bonvecchio@insp.mx. LA - eng PT - Journal Article DEP - 20260929 PL - United States TA - Arch Med Res JT - Archives of medical research JID - 9312706 SB - IM OTO - NOTNLM OT - Dietary guidelines OT - Food culture OT - Food environment OT - Formative research OT - Qualitative methodology EDAT- 2026/09/29 23:29 MHDA- 2026/09/29 23:29 CRDT- 2026/09/29 18:19 PHST- 2025/09/19 00:00 [received] PHST- 2026/06/15 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/29 23:29 [medline] PHST- 2026/09/29 23:29 [pubmed] PHST- 2026/09/29 18:19 [entrez] AID - S0188-4409(26)00153-0 [pii] AID - 10.1016/j.arcmed.2026.103531 [doi] PST - aheadofprint SO - Arch Med Res. 2026 Sep 29;58(1):103531. doi: 10.1016/j.arcmed.2026.103531. PMID- 42809924 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 205 DP - 2026 Dec TI - Age- and sex-specific CT reference trajectories for abdominal organ volumes and attenuation: a large-scale automated analysis. PG - 113247 LID - S0720-048X(26)00595-4 [pii] LID - 10.1016/j.ejrad.2026.113247 [doi] AB - BACKGROUND: Reference values for adult abdominal organ volumes and attenuation remain limited, although they are important for accurate CT interpretation and opportunistic imaging assessment. METHODS: This retrospective cross-sectional study included 25,161 abdominal CT examinations from 15,408 adult patients aged 18-100 years, comprising 5,559 women, 9,848 men, and one non-binary patient. Attenuation measurements were derived from the unenhanced phase available in 9,548 examinations. Organ volumes and attenuation values were quantified using a fully automated segmentation pipeline (TotalSegmentator). Percentile reference curves (P3-P97) were generated using generalized additive models for location, scale, and shape (GAMLSS). RESULTS: Men had higher organ volumes than women across nearly all organs and age groups. Age-group-averaged model-derived P50 estimates showed organ-specific trajectories: liver, pancreas, and kidney volumes followed an inverted U-shaped pattern, increasing from young adulthood to midlife and declining thereafter. Liver volume peaked in midlife and declined thereafter, rising from 1,303.1 to 1,450.2 mL in women and from 1,560.7 to 1,774.1 mL in men, before decreasing to 1,019.6 and 1,234.9 mL at 90-100 years, respectively. Pancreatic volume peaked at 40-49 years (67.7 mL in women; 86.2 mL in men) and declined to 35.5/46.4 mL. Right/left kidney volumes increased from 115.6/126.6 to 138.2/143.2 mL in women and from 154.6/163.4 to 179.4/183.3 mL in men, before declining to 87.8/84.5 and 113.1/112.8 mL, respectively. Spleen volume decreased overall with age, whereas adrenal volume increased into later adulthood. Organ attenuation generally declined with age, most markedly in the pancreas and adrenal glands. CONCLUSION: Percentile-based trajectories derived from large-scale automated CT analysis provide descriptive reference values for abdominal organ volume and attenuation across adulthood. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Reschke, Philipp AU - Reschke P AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. Electronic address: Philipp.reschke@outlook.de. FAU - Booz, Christian AU - Booz C AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Koch, Vitali AU - Koch V AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Gotta, Jennifer AU - Gotta J AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Hohne, Elena AU - Hohne E AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Martin, Simon S AU - Martin SS AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Yel, Ibrahim AU - Yel I AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Mahmoudi, Scherwin AU - Mahmoudi S AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Bernatz, Simon AU - Bernatz S AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Nica, Andreea I AU - Nica AI AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Gulli, Claudia AU - Gulli C AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany; Diagnostic and Interventional Radiology Unit, Department of Dental and Morphological and Functional Imaging, University Hospital Messina, Messina, Italy. FAU - D'Angelo, Tommaso AU - D'Angelo T AD - Diagnostic and Interventional Radiology Unit, Department of Dental and Morphological and Functional Imaging, University Hospital Messina, Messina, Italy. FAU - Gruber-Rouh, Tatjana AU - Gruber-Rouh T AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Eichler, Katrin AU - Eichler K AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Vogl, Thomas J AU - Vogl TJ AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Gruenewald, Leon D AU - Gruenewald LD AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. LA - eng PT - Journal Article DEP - 20260912 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM MH - Humans MH - Male MH - Female MH - *Tomography, X-Ray Computed/statistics & numerical data/standards MH - Reference Values MH - Adolescent MH - Organ Size/physiology MH - Middle Aged MH - Aged MH - Adult MH - Aged, 80 and over MH - *Radiography, Abdominal/statistics & numerical data/standards MH - Reproducibility of Results MH - Young Adult MH - Sensitivity and Specificity MH - *Aging/physiology MH - Age Distribution MH - *Pattern Recognition, Automated/methods MH - Sex Distribution MH - *Radiographic Image Interpretation, Computer-Assisted/methods MH - *Imaging, Three-Dimensional/standards/statistics & numerical data MH - Retrospective Studies MH - *Viscera/diagnostic imaging COIS- Declaration of competing interest Christian Booz received speaking fees from Siemens Healthineers. Ibrahim Yel received a speaking fee from Siemens Healthineers. The other authors have no potential conflict of interest to disclose. EDAT- 2026/09/29 23:29 MHDA- 2026/10/24 05:34 CRDT- 2026/09/29 18:02 PHST- 2026/03/31 00:00 [received] PHST- 2026/07/15 00:00 [revised] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/10/24 05:34 [medline] PHST- 2026/09/29 23:29 [pubmed] PHST- 2026/09/29 18:02 [entrez] AID - S0720-048X(26)00595-4 [pii] AID - 10.1016/j.ejrad.2026.113247 [doi] PST - ppublish SO - Eur J Radiol. 2026 Dec;205:113247. doi: 10.1016/j.ejrad.2026.113247. Epub 2026 Sep 12. PMID- 42809284 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20261002 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 9 DP - 2026 Sep 1 TI - Prevalence of Overweight and Obesity Among Children Younger Than 5 Years in India. PG - e2636750 LID - 10.1001/jamanetworkopen.2026.36750 [doi] LID - e2636750 AB - IMPORTANCE: Evidence is lacking on long-term trends across Indian states and union territories (UTs) and on the attainability of the 2030 Global Nutrition Target (GNT) goals within these specific regions. OBJECTIVES: To estimate the trends in overweight and obesity among children younger than 5 years across 36 states and UTs in India between 2006 and 2024 and to assess the feasibility of achieving the GNT of restricting the overweight burden to 5% or less by 2030. DESIGN, SETTING, AND PARTICIPANTS: For this cross-sectional study, microdata and aggregate data were used from the 4 most recent waves of the National Family Health Survey (repeated cross-sectional surveys conducted between January 1, 2006, and December 31, 2024). The analysis included individual-level samples of 41 306 children in 2006, 225 002 in 2016, and 201 687 in 2021, alongside aggregate estimates of overweight from the 2024 wave. Data were analyzed in January and updated in July 2026. MAIN OUTCOMES AND MEASURES: Following World Health Organization definitions of overweight and obesity in children younger than 5 years (overweight is defined as weight for height >2 SDs above the World Health Organization median and obesity as >3 SDs), their prevalence and standardized annualized changes for 5 timeframes (2006-2016, 2016-2021, 2021-2024, 2006-2021, and 2006-2024) were computed. Additionally, the fractional logistic regression was used to model national and state-level overweight trajectories, forecasting probability of achieving the 5% or less 2030 GNT threshold. RESULTS: The final sample included 467 995 children (241 645 [51.6%] male, 226 350 [48.4%] female) aged 0 to 59 months from NFHSs conducted between 2006 and 2021. Mean (SD) child age remained consistent from 2006 to 2021: 30.1 (17.1) months in 2006, 30.1 (17.0) months in 2016, and 29.9 (17.2) months in 2021. Between 2006 and 2021, the prevalence of overweight increased from 1.55% to 3.42%, whereas obesity prevalence increased from 0.50% to 1.30% before overweight prevalence decreased to 1.3% in 2024. Although India was projected to sustain the 2030 overweight target nationally, 9 states and UTs (Arunachal Pradesh, Assam, Himachal Pradesh, Jammu and Kashmir, Kerala, Mizoram, Nagaland, Sikkim, and Tripura) maintained a low to moderate probability of adherence. CONCLUSIONS AND RELEVANCE: In this cross-sectional study of Indian children younger than 5 years from 2006 to 2024, a historical overweight increase reversed in 2024. However, profound subnational disparities remained, suggesting that targeted regional interventions are needed to achieve the 2030 GNT. FAU - Rai, Rajesh Kumar AU - Rai RK AD - Division of Global Health Management and Policy, School of Public Health, San Diego State University, San Diego, California. AD - Birbhum Population Project, Society for Health and Demographic Surveillance, Suri, West Bengal, India. AD - ImplactLoop Ltd, London, UK. AD - Human Nutrition Unit, Institute of Nutrition, Mahidol University, Phutthamonthon, Nakhon Pathom, Thailand. AD - Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Matsuzaki, Mika AU - Matsuzaki M AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. AD - Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Phutthamonthon, Nakhon Pathom, Thailand. FAU - De Neve, Jan-Walter AU - De Neve JW AD - Division of Global Health Management and Policy, School of Public Health, San Diego State University, San Diego, California. AD - Heidelberg Institute of Global Health, Faculty of Medicine and University Hospital, University of Heidelberg, Heidelberg, Germany. FAU - Zafar, Sumaira AU - Zafar S AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Phutthamonthon, Nakhon Pathom, Thailand. FAU - Bromage, Sabri AU - Bromage S AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Phutthamonthon, Nakhon Pathom, Thailand. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Kim, Rockli AU - Kim R AD - Division of Health Policy and Management, College of Health Science, Korea University, Seoul, South Korea. AD - Interdisciplinary Program in Precision Public Health, Department of Public Health Sciences, Graduate School of Korea University, Seoul, South Korea. FAU - Subramanian, S V AU - Subramanian SV AD - Harvard Center for Population and Development Studies, Cambridge, Massachusetts. AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - India/epidemiology MH - Child, Preschool MH - Male MH - Cross-Sectional Studies MH - Female MH - Prevalence MH - Infant MH - *Overweight/epidemiology MH - *Pediatric Obesity/epidemiology PMC - PMC13624874 COIS- Conflict of Interest Disclosures: None reported. EDAT- 2026/09/29 19:04 MHDA- 2026/09/29 19:05 PMCR- 2026/09/29 CRDT- 2026/09/29 11:32 PHST- 2026/09/29 19:05 [medline] PHST- 2026/09/29 19:04 [pubmed] PHST- 2026/09/29 11:32 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 2854611 [pii] AID - zoi260985 [pii] AID - 10.1001/jamanetworkopen.2026.36750 [doi] PST - epublish SO - JAMA Netw Open. 2026 Sep 1;9(9):e2636750. doi: 10.1001/jamanetworkopen.2026.36750. PMID- 42809071 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 36 IP - 11 DP - 2026 Nov TI - Development and Validation of a Machine Learning Model for Predicting One-year Anemia After Bariatric Surgery: A Multicenter Study. PG - 5595-5606 LID - 10.1007/s11695-026-08965-y [doi] AB - INTRODUCTION: Anemia is a common nutritional complication after bariatric surgery, but preoperative tools for individualized risk assessment remain limited. This study aims to develop and externally validate a machine learning model for predicting anemia status one year after bariatric surgery. METHODS: This multicenter study included patients aged 16-65 years undergoing sleeve gastrectomy or Roux-en-Y gastric bypass. Patients from one hospital formed the derivation cohort, and patients from two independent hospitals formed the external validation cohort. Forty-five preoperative variables were evaluated using logistic regression, random forest, support vector machine, and extreme gradient boosting. Model discrimination, calibration, and clinical utility were assessed and compared with blinded predictions from 10 clinicians with different levels of experience. RESULTS: The derivation cohort included 511 patients (409 training, 102 internal testing), and the external cohort included 300 patients. One-year anemia occurred in 39.6%, 39.2%, and 19.0% of patients in the training, testing, and external validation cohorts, respectively. Random forest showed the most favorable overall performance profile and was simplified to seven predictors. The final model achieved an area under the curve of 0.827 (95% CI, 0.746-0.896) in the testing set and 0.823 (95% CI, 0.771-0.873) in the external validation cohort, with satisfactory calibration and decision-curve net benefit. In external validation, the model outperformed junior, middle-level, and senior clinicians and remained superior in clinician-defined challenging cases. CONCLUSIONS: A seven-variable preoperative model showed good discrimination for one-year anemia status after bariatric surgery and may support individualized postoperative monitoring and nutritional care. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Nie, Yuntao AU - Nie Y AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Tianshi AU - Wang T AD - Department of General Surgery, Second Hospital of Shandong University, Jinan, China. FAU - Tang, Haibo AU - Tang H AD - Department of General Surgery, Third Xiangya Hospital, Changsha, China. FAU - Huang, Yishan AU - Huang Y AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Zhe AU - Wang Z AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Pengpeng AU - Wang P AUID- ORCID: 0000-0002-0161-1933 AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Siqi AU - Wang S AUID- ORCID: 0000-0001-9401-0880 AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Genzheng AU - Liu G AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Lin, Ximing AU - Lin X AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Ran, Shuman AU - Ran S AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Yan AU - Liu Y AD - Department of Gastrointestinal Metabolic Surgery, Zhengzhou Central Hospital, Zhengzhou, China. FAU - Zhu, Ming AU - Zhu M AD - Department of Gastrointestinal Surgery, Jining First People's Hospital, Jining, China. FAU - Hu, Jingwei AU - Hu J AD - Department of Gastrointestinal Surgery, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Li, Chunhui AU - Li C AD - Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Zhang, Nianrong AU - Zhang N AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Baoyin AU - Liu B AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Zhu, Liyong AU - Zhu L AUID- ORCID: 0000-0002-4666-8458 AD - Department of General Surgery, Third Xiangya Hospital, Changsha, China. zly8128@csu.edu.cn. FAU - Ding, Yinlu AU - Ding Y AD - Department of General Surgery, Second Hospital of Shandong University, Jinan, China. dingyinlu@126.com. FAU - Meng, Hua AU - Meng H AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. menghua@zryhyy.com.cn. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260929 PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 SB - IM MH - Humans MH - *Anemia/etiology/epidemiology/diagnosis MH - Female MH - Middle Aged MH - Adult MH - Predictive Learning Models MH - *Machine Learning MH - Male MH - Adolescent MH - *Postoperative Complications/etiology/epidemiology MH - *Bariatric Surgery/adverse effects MH - Random Forest MH - *Obesity, Morbid/surgery MH - Aged MH - Young Adult MH - Risk Assessment MH - Classification Algorithms MH - Prediction Algorithms MH - Boosting Machine Learning Algorithms MH - *Gastric Bypass/adverse effects MH - Gastrectomy/adverse effects OTO - NOTNLM OT - Bariatric surgery OT - Machine learning OT - Postoperative anemia OT - Prediction model COIS- Declarations. Ethical Approval: This study was conducted in accordance with the Helsinki Declaration and approved by the IRB of Hospital 1 (approval number blinded for peer review). Informed Consent: The requirement for informed consent was waived. Competing interests: The authors declare no competing interests. EDAT- 2026/09/29 19:04 MHDA- 2026/10/27 17:29 CRDT- 2026/09/29 11:12 PHST- 2026/06/25 00:00 [received] PHST- 2026/09/26 00:00 [accepted] PHST- 2026/09/15 00:00 [revised] PHST- 2026/10/27 17:29 [medline] PHST- 2026/09/29 19:04 [pubmed] PHST- 2026/09/29 11:12 [entrez] AID - 10.1007/s11695-026-08965-y [pii] AID - 10.1007/s11695-026-08965-y [doi] PST - ppublish SO - Obes Surg. 2026 Nov;36(11):5595-5606. doi: 10.1007/s11695-026-08965-y. Epub 2026 Sep 29. PMID- 42808984 OWN - NLM STAT- Publisher LR - 20260929 IS - 1935-5548 (Electronic) IS - 0149-5992 (Linking) DP - 2026 Sep 29 TI - Insulin Dose-Adjusted Hemoglobin A1c Has Suboptimal Performance for Identifying C-Peptide-Defined Partial Remission: The SEARCH for Diabetes in Youth Study. LID - dc261313 [pii] LID - 10.2337/dc26-1313 [doi] AB - OBJECTIVE: Insulin dose-adjusted hemoglobin A1c (IDAA1c = HbA1c [%] + [4 x total daily dose in units/kg/day]) /=85th percentile [overweight or obese]) using Wilcoxon rank sum and Fisher exact tests. Sensitivity, specificity, and receiver operating characteristic (ROC) AUC of IDAA1c /=0.91 ng/mL with an ROC AUC of 0.77. Among participants with overweight or obesity, sensitivity was 45% and specificity 81%. A Youden index-derived cutoff of IDAA1c /= 5 events/h in PSG. An AI model using the Dlib tool identified facial landmarks, and the Hough transform calculated variables from these coordinates. Measurements by humans, the AI model, and a manually adjusted AI model were compared. Random forest identified the top 10 variable importance for the OSA prediction model. RESULTS: Forty-three children with moderate-to-severe OSA and 43 age-, gender-, and obesity-matched controls were included. Shared predictors across models were mandibular plane angle, maxillary-mandibular relationship, lower facial length, and lower facial proportion. Additional predictors for the AI model included lower- and mid-face projection, while the adjusted AI model added mid-face projection, retrusive mandible, and cervicomental angle. The area under the curve (AUC) values for moderate-to-severe OSA prediction were similar in human, AI model, and adjusted AI model (0.74 vs 0.71 vs 0.70, P for DeltaAUC > 0.05). The AI model significantly reduced measurement time (human vs AI vs adjusted AI = 511.4 vs 0.85 vs 15.8 seconds, P < .001). CONCLUSION: The AI-powered photogrammetry analysis system is a rapid and reliable tool with comparable performance to human measurements in evaluating pediatric OSA. CI - (c) 2026 American Academy of Otolaryngology-Head and Neck Surgery Foundation. FAU - Hsueh, Wan-Yi AU - Hsueh WY AD - Department of Otolaryngology, Hsinchu Cathay General Hospital, Hsinchu, Taiwan. FAU - Kang, Kun-Tai AU - Kang KT AUID- ORCID: 0000-0002-4421-9261 AD - Department of Otolaryngology and Sleep Center, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan. AD - Department of Otolaryngology, National Taiwan University Hospital and Children's Hospital, Taipei, Taiwan. FAU - Huang, Shih-Hsu AU - Huang SH AUID- ORCID: 0000-0001-8583-8459 AD - Department of Electronic Engineering, Chung Yuan Christian University, Taoyuan, Taiwan. FAU - Lin, Chia-Jo AU - Lin CJ AD - Department of Electronic Engineering, Chung Yuan Christian University, Taoyuan, Taiwan. FAU - Su, Chih-Wen AU - Su CW AD - Department of Information & Computer Engineering, Chung Yuan Christian University, Taoyuan, Taiwan. FAU - Hsu, Wei-Chung AU - Hsu WC AD - Department of Otolaryngology, National Taiwan University Hospital and Children's Hospital, Taipei, Taiwan. AD - Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei, Taiwan. AD - Sleep Center, National Taiwan University Hospital, Taipei, Taiwan. LA - eng PT - Journal Article DEP - 20260929 PL - England TA - Otolaryngol Head Neck Surg JT - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JID - 8508176 SB - IM OTO - NOTNLM OT - apnea-hypopnea index OT - artificial intelligence OT - child OT - craniofacial morphology OT - obstructive sleep apnea syndrome OT - photogrammetry EDAT- 2026/09/29 12:28 MHDA- 2026/09/29 12:28 CRDT- 2026/09/29 08:24 PHST- 2026/08/05 00:00 [revised] PHST- 2025/12/10 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/09/29 12:28 [medline] PHST- 2026/09/29 12:28 [pubmed] PHST- 2026/09/29 08:24 [entrez] AID - 10.1002/ohn.70463 [doi] PST - aheadofprint SO - Otolaryngol Head Neck Surg. 2026 Sep 29. doi: 10.1002/ohn.70463. PMID- 42808373 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20261001 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2026 IP - 1 DP - 2026 TI - Provegetarian Food Pattern and Obesity Among Saudi Non-Pregnant Females of Reproductive Age. PG - e4023284 LID - 10.1155/bmri/4023284 [doi] LID - 4023284 AB - AIM: Evidence linking plant-based dietary patterns with adiposity in Middle Eastern populations is limited. This study examined associations between provegetarian diet index (PDI) scores and measures of general and central adiposity among Saudi women of reproductive age. METHODS: This cross-sectional study included 205 non-pregnant Saudi women aged 18-40 years systematically recruited from two tertiary hospitals in Jeddah. Dietary intake was assessed using a validated 91-item food frequency questionnaire and used to calculate PDI scores. Anthropometric measures included body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR). Multivariable regression models were adjusted for potential confounders. RESULTS: Higher PDI scores were generally characterised by higher intakes of fibre, polyunsaturated fatty acids, vitamin C and beta-carotene and lower intakes of saturated fatty acids and cholesterol. PDI score was weakly inversely correlated with WHR (r = -0.144, p < 0.05). Adjusted analyses showed no significant associations with continuous BMI, WC, WHR or WHtR (all p > 0.05). Higher PDI scores were associated with modestly lower odds of WHR-defined central obesity (adjusted OR = 0.972; 95% CI: 0.947-0.997; p = 0.031), whereas associations with WC- and WHtR-defined central obesity were not significant. CONCLUSION: PDI scores were not consistently associated with measures of general or central adiposity. Although higher scores were associated with modestly lower odds of WHR-defined central obesity, this isolated finding was not supported by the continuous adiposity outcomes and should be considered exploratory. Prospective studies are needed to determine whether this association is reproducible. CI - Copyright (c) 2026 Eman M. Alissa et al. BioMed Research International published by John Wiley & Sons Ltd. FAU - Alissa, Eman M AU - Alissa EM AUID- ORCID: 0000-0001-8905-4870 AD - Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa. FAU - Algarni, Samiah A AU - Algarni SA AUID- ORCID: 0009-0005-1204-8639 AD - Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa. FAU - Khaffji, Azza J AU - Khaffji AJ AD - Obstetrics and Gynecology, King Abdulaziz Hospital and Oncology Center, Jeddah, Saudi Arabia. FAU - Al Mansouri, Nisma M AU - Al Mansouri NM AUID- ORCID: 0000-0002-4346-1291 AD - Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa. LA - eng GR - 30-37/King Abdulaziz City for Science and Technology/ PT - Journal Article PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Humans MH - Female MH - Saudi Arabia/epidemiology MH - Adult MH - *Obesity/epidemiology/physiopathology MH - Body Mass Index MH - Waist-Hip Ratio MH - Adolescent MH - *Diet, Vegetarian MH - Cross-Sectional Studies MH - Waist Circumference/physiology MH - Young Adult MH - *Feeding Behavior MH - Adiposity PMC - PMC13621456 OTO - NOTNLM OT - BMI OT - FFQ OT - diet pattern OT - vegetarian OT - waist circumference OT - waist-to-hip ratio COIS- The authors declare no conflicts of interest. EDAT- 2026/09/29 12:28 MHDA- 2026/09/29 12:29 PMCR- 2026/09/29 CRDT- 2026/09/29 08:02 PHST- 2026/09/16 00:00 [revised] PHST- 2026/06/02 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/09/29 12:29 [medline] PHST- 2026/09/29 12:28 [pubmed] PHST- 2026/09/29 08:02 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - BMRI4023284 [pii] AID - 10.1155/bmri/4023284 [doi] PST - ppublish SO - Biomed Res Int. 2026;2026(1):e4023284. doi: 10.1155/bmri/4023284. PMID- 42807469 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260929 LR - 20260930 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Therapeutic response to exclusive enteral nutrition correlates with suppressed IL-17 signaling activity and diminished IL-1beta secretion in pediatric Crohn's disease. PG - 1901066 LID - 10.3389/fnut.2026.1901066 [doi] LID - 1901066 AB - BACKGROUND: To identify molecular correlates associated with therapeutic outcomes of exclusive enteral nutrition (EEN) in pediatric Crohn's disease (PCD). METHODS: This prospective observational cohort study recruited 27 treatment-naive pediatric patients with endoscopically active PCD. Intestinal mucosal tissues were collected via endoscopy at baseline and after EEN treatment. RNA sequencing, principal component analysis (PCA), protein-protein interaction (PPI) analysis, and quantitative real-time polymerase chain reaction (qRT-PCR) were performed to identify and validate differentially expressed genes (DEGs). Patients were classified into mucosal healing [MH, Simple Endoscopic Score for Crohn's Disease (SES-CD) < 3, n = 13] and non-mucosal healing (NMH, SES-CD >/= 3 with ulcers, n = 14) groups according to post-treatment SES-CD. RESULTS: PCA revealed partial transcriptomic segregation between the MH and NMH groups after EEN. Bioinformatic enrichment analysis identified the IL-17 signaling pathway as the most significantly enriched pathway, encompassing nine core DEGs. Integrated qRT-PCR validation and PPI network analysis pinpointed IL-1beta as the key target gene. Correlation analysis demonstrated that intestinal mucosal IL-1beta expression was moderately and positively correlated with SES-CD scores (P = 0.001, r = 0.42, 95% CI: 0.17-0.63), Lewis scores (P < 0.001, r = 0.65, 95% CI: 0.41-0.79), and weighted Pediatric Crohn's Disease Activity Index (wPCDAI) values (P < 0.001, r = 0.51, 95% CI: 0.26-0.69). Moreover, compared with the NMH group, the MH group exhibited lower mucosal expression levels of IL-17A [MH: 0.50 (1.42) vs. NMH: 2.58 (2.05), P = 0.03], IL-17RA (MH: 0.95 +/- 0.37 vs. NMH: 1.34 +/- 0.53, P = 0.04), and IL-17RB [MH: 1.18 (0.54) vs. NMH: 1.64 (1.32), P < 0.01] after EEN treatment. CONCLUSIONS: EEN attenuates intestinal inflammation in PCD, and this therapeutic response may associate with suppressed IL-17 signaling activity and reduced IL-1beta secretion. CI - Copyright (c) 2026 Tang, Wang, Tang, Zheng, Shi, Meng and Huang. FAU - Tang, Wenjuan AU - Tang W AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Wang, Yuhuan AU - Wang Y AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Tang, Zifei AU - Tang Z AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Zheng, Cuifang AU - Zheng C AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Shi, Jieru AU - Shi J AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Meng, Yingying AU - Meng Y AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Huang, Ying AU - Huang Y AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260914 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13618058 OTO - NOTNLM OT - Crohn's disease OT - EEN OT - IL-17 OT - IL-1beta OT - pediatric COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/29 12:28 MHDA- 2026/09/29 12:29 PMCR- 2026/09/14 CRDT- 2026/09/29 06:33 PHST- 2026/06/05 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/29 12:29 [medline] PHST- 2026/09/29 12:28 [pubmed] PHST- 2026/09/29 06:33 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - 10.3389/fnut.2026.1901066 [doi] PST - epublish SO - Front Nutr. 2026 Sep 14;13:1901066. doi: 10.3389/fnut.2026.1901066. eCollection 2026. PMID- 42807456 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260929 LR - 20260930 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Integrated multi-omics analysis to explore correlations among cord blood IGF-1 levels, metabolomic profiles, and meconium gut microbiota in small-for-gestational-age neonates. PG - 1942176 LID - 10.3389/fped.2026.1942176 [doi] LID - 1942176 AB - BACKGROUND: Small for gestational age (SGA) infants carry high risks of neonatal complications and lifelong metabolic disorders. This study explored correlations among cord blood IGF-1, cord blood metabolome, and meconium microbiota in SGA neonates to clarify the underlying pathophysiology. METHODS: We consecutively recruited 113 term newborns (53 SGA, 60 AGA) delivered at Hainan Women and Children's Medical Centre from June 2024 to March 2025. Cord blood IGF-1 was tested via chemiluminescence. UHPLC-MS/MS untargeted metabolomics and 16S rRNA high-throughput sequencing were applied to characterize cord blood metabolites and meconium microbiota. Intergroup differences and partial Spearman correlations across IGF-1, metabolites, microbes and birth indices were analyzed, adjusting for gestational age, infant sex, and maternal delivery mode,where applicable. RESULTS: (1) SGA infants had markedly lower cord blood IGF-1 (P < 0.001), which positively correlated with birth weight and length. (partial Spearman r = 0.634 and 0.494, respectively, P < 0.001, after adjusting for gestational age, sex, and maternal BMI). (2) Two groups presented distinct metabolic profiles. SGA infants showed depleted glycerophospholipids, elevated chlorobenzene pollutants, and altered pathways involving bile secretion, choline and steroid metabolism. (3) No alpha diversity difference existed, yet beta diversity confirmed divergent microbial structures (R(2) = 0.0284, P = 0.046). SGA overrepresented Clostridium and Klebsiella, with reduced facultative pioneer bacteria. (4) SGA-enriched anaerobes negatively correlated with birth size and IGF-1, while chlorobenzene levels were positively associated with these pathogenic genera. CONCLUSIONS: SGA neonates feature suppressed IGF-1, intrauterine metabolic disorders and disordered initial gut colonization. Disturbed prenatal metabolism and pollutant exposure may jointly drive aberrant early microbiota development in growth-restricted newborns. The cross-sectional design precludes causal inference, and the chlorobenzene finding warrants independent validation. CI - (c) 2026 Li, Wang, Luo, Xie, Duan, Wang and Huang. FAU - Li, Yuanlong AU - Li Y AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Wang, Haizhen AU - Wang H AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Luo, Liangying AU - Luo L AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Xie, Junwei AU - Xie J AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Duan, Yumei AU - Duan Y AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Wang, Junqiong AU - Wang J AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Huang, Yan AU - Huang Y AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. LA - eng PT - Journal Article DEP - 20260914 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13617061 OTO - NOTNLM OT - 16S rRNA microbiota sequencing OT - cord blood metabolome OT - gut microbiota OT - insulin-like growth factor-1 OT - small for gestational age COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/29 12:28 MHDA- 2026/09/29 12:29 PMCR- 2026/09/14 CRDT- 2026/09/29 06:33 PHST- 2026/07/19 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/09/29 12:29 [medline] PHST- 2026/09/29 12:28 [pubmed] PHST- 2026/09/29 06:33 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - 10.3389/fped.2026.1942176 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 14;14:1942176. doi: 10.3389/fped.2026.1942176. eCollection 2026. PMID- 42804965 OWN - NLM STAT- Publisher LR - 20260928 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 153 DP - 2026 Aug 29 TI - Parental experiences and understandings of stunting in children aged 1-36 mo in the Northern Province of Rwanda. PG - 113411 LID - S0899-9007(26)00318-7 [pii] LID - 10.1016/j.nut.2026.113411 [doi] AB - OBJECTIVES: Childhood stunting remains a major public health problem in the Northern Province of Rwanda, where approximately 27.1% of children aged 1-36 mo are stunted. While many risk factors have been documented, less is known about social and parenting processes in high-risk conditions of undernutrition for children. In this study, we aimed to explore parental experiences and understandings of the risk of childhood stunting in the Northern Province of Rwanda. METHODS: We conducted a qualitative study using focus group discussions with 120 parents-mothers and fathers separately-of children aged 1-36 mo across all five districts of the Northern Province of Rwanda. Data were analyzed using a reflexive thematic analysis approach. RESULTS: Parents described interconnected household and caregiving processes perceived to influence children's nutrition and growth. Thematically, household power struggles and resource diversion, vulnerabilities during the first 1000 d, a paradox whereby food and livestock assets did not always benefit children, and fragile substitute care arrangements when mothers needed to go out for work highlighted how intrahousehold allocation of resources, caregiving practices, and competing economic priorities shaped children's nutritional environments. The themes indicate that parents see intrahousehold resource allocation and caregiving as affecting the link between food resources and child growth. CONCLUSIONS: Parents in Rwanda's Northern Province see childhood growth as shaped by interconnected household power relations, caregiving, and resource allocation practices in the first 1000 d. Policies should provide more decision-making power and resources that benefit infants by promoting shared household decisions, empowering mothers, aligning livestock and market incentives with infant nutrition, and restoring reliable substitute care through public platforms. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Ndagijimana, Albert AU - Ndagijimana A AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden; University of Rwanda, College of Medicine and Health Sciences, School of Public Health, Kigali, Rwanda. Electronic address: albert.ndagijimana@umu.se. FAU - Wiklund, Maria AU - Wiklund M AD - Department of Community Medicine and Rehabilitation, Umea University, Umea, Sweden. FAU - Lind, Torbjorn AU - Lind T AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. LA - eng PT - Journal Article DEP - 20260829 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM OTO - NOTNLM OT - Caregiving and household dynamics OT - Childhood stunting OT - First 1000 d OT - Qualitative research OT - Rwanda COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/28 23:28 MHDA- 2026/09/28 23:28 CRDT- 2026/09/28 18:05 PHST- 2026/03/25 00:00 [received] PHST- 2026/08/25 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/28 23:28 [medline] PHST- 2026/09/28 23:28 [pubmed] PHST- 2026/09/28 18:05 [entrez] AID - S0899-9007(26)00318-7 [pii] AID - 10.1016/j.nut.2026.113411 [doi] PST - aheadofprint SO - Nutrition. 2026 Aug 29;153:113411. doi: 10.1016/j.nut.2026.113411. PMID- 42804465 OWN - NLM STAT- Publisher LR - 20260930 IS - 1469-445X (Electronic) IS - 0958-0670 (Print) IS - 0958-0670 (Linking) DP - 2026 Sep 28 TI - Association between dietary fatty acids and all-cause mortality in patients with cirrhosis: A cohort study. LID - 10.1113/EP093526 [doi] AB - Liver cirrhosis imposes a substantial global burden, with complications driving high mortality. Diet is pivotal in managing liver disease progression and cirrhosis-related death. This study investigated associations between total fat intake, specific dietary fatty acid subclasses and all-cause mortality in cirrhotic patients. In this prospective cohort study, 121 ambulatory patients with recently diagnosed cirrhosis (/=4 days/week) were significant associated with a lower probability of VD insufficiency. The global predictive scorecard achieved an optimism-corrected area under the receiver operating characteristic curve (optimism-corrected AUC) of 0.714. Crucially, the subgroup model restricted to overweight individuals (BMI >/= 25 kg/m(2)) demonstrated acceptable exploratory discrimination (optimism-corrected AUC = 0.768, sensitivity 69.2%, specificity 89.7%), serving as a preliminary proof-of-concept assessment for risk stratification. CONCLUSION: By integrating body composition dynamics and cultural habits, this cost-effective model provides a preliminary, exploratory non-invasive screening structure for Paraguayan youth that warrants further multi-center prospective validation before clinical implementation. CI - Copyright (c) 2026 Gonzalez, Mino, Espinoza, Cano, Recalde, Miguel and Ishikawa. FAU - Gonzalez, Anabel AU - Gonzalez A AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Mino, Camila AU - Mino C AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Espinoza, Elena AU - Espinoza E AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Cano, Marlene AU - Cano M AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Recalde, Milciades AU - Recalde M AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Miguel, Carlos AU - Miguel C AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Ishikawa, Dai AU - Ishikawa D AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Japan International Cooperation Agency (JICA), Asuncion, Paraguay. LA - eng PT - Journal Article DEP - 20260911 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13612359 OTO - NOTNLM OT - body composition OT - logistic regression OT - mate consumption OT - predictive model OT - traditional habit OT - vitamin D insufficiency COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/27 02:27 MHDA- 2026/09/27 02:28 PMCR- 2026/09/11 CRDT- 2026/09/26 05:12 PHST- 2026/07/30 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/27 02:28 [medline] PHST- 2026/09/27 02:27 [pubmed] PHST- 2026/09/26 05:12 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.3389/fnut.2026.1953400 [doi] PST - epublish SO - Front Nutr. 2026 Sep 11;13:1953400. doi: 10.3389/fnut.2026.1953400. eCollection 2026. PMID- 42798427 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260927 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical literacy and adolescent mental well-being: A chain mediation of basic psychological needs satisfaction and emotion regulation. PG - 1950111 LID - 10.3389/fpsyg.2026.1950111 [doi] LID - 1950111 AB - BACKGROUND: Adolescent mental wellbeing is a pressing global concern. Physical literacy (PL) - the motivation, confidence, physical competence, knowledge, and understanding to value physical activity for life - has emerged as a potentially protective factor for mental wellbeing. However, the mechanisms linking PL to mental wellbeing remain poorly understood. Drawing on Self-Determination Theory and emotion regulation theory, this study examined whether basic psychological needs satisfaction (BPNS) and emotion regulation serve as sequential mediators in the PL-mental wellbeing relationship among adolescents. METHODS: A cross-sectional survey was conducted in November 2024 with 687 Chinese middle school students from Hubei Province (48.3% female; aged 12-16 years), recruited using stratified cluster sampling from three public schools. Participants completed validated Chinese measures of physical literacy (PPLI), basic psychological needs (BPNSFS), emotion regulation (ERQ), and mental wellbeing (WEMWBS). Covariance-based structural equation modeling (robust maximum likelihood) with bias-corrected bootstrapping (5,000 resamples) tested the chain mediation model. RESULTS: The final analytical sample comprised 687 adolescents (48.3% female), who reported moderate levels of PL (M = 3.42, SD = 0.68), BPNS (M = 3.56, SD = 0.62), cognitive reappraisal (M = 4.52, SD = 1.08), and mental wellbeing (M = 3.51, SD = 0.71). PL was positively associated with mental wellbeing (beta = 0.38, p < 0.001), the standardized total effect estimated in the structural equation model. The direct effect remained significant (beta = 0.14, p = 0.006). The chain mediation pathway - PL --> BPNS --> emotion regulation --> mental wellbeing - was significant (indirect effect = 0.12, 95% CI [0.08, 0.17]), accounting for 31.6% of the total effect. Individual mediation paths through BPNS (indirect effect = 0.05, 95% CI [0.01, 0.09]) and emotion regulation (indirect effect = 0.07, 95% CI [0.04, 0.11]) were also significant. The model explained 42% of the variance in mental wellbeing. CONCLUSION: These findings suggest that PL is associated with adolescent mental wellbeing through a sequential pathway involving BPNS and emotion regulation. The results highlight the potential value of PL development and need-supportive environments in educational settings. Future longitudinal research is needed to examine temporal dynamics. CI - Copyright (c) 2026 Zhang. FAU - Zhang, Bing AU - Zhang B AD - Institute of Physical Education, Huanggang Normal University, Huanggang, Hubei, China. LA - eng PT - Journal Article DEP - 20260911 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13612352 OTO - NOTNLM OT - Self-Determination Theory OT - adolescents OT - basic psychological needs satisfaction OT - chain mediation OT - emotion regulation OT - mental wellbeing OT - physical literacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/11 CRDT- 2026/09/26 04:58 PHST- 2026/07/27 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 04:58 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1950111 [doi] PST - epublish SO - Front Psychol. 2026 Sep 11;17:1950111. doi: 10.3389/fpsyg.2026.1950111. eCollection 2026. PMID- 42798248 OWN - NLM STAT- Publisher LR - 20260926 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) DP - 2026 Sep 26 TI - Effects of virtual reality-based aerobic exercise versus traditional aerobic exercise training on physical fitness, functional capacity, and quality of life in individuals with Down syndrome: DOWNFIT (Down Syndrome Fitness Intervention Trial) randomized controlled trial. PG - 1-16 LID - 10.1080/09638288.2026.2735453 [doi] AB - PURPOSE: To compare the effects of virtual reality-based aerobic exercise (VR-AE) and traditional aerobic exercise (TAE) on on physical fitness, functional capacity, and quality of life (QoL) in adolescents with Down syndrome (DS). METHODS: Forty adolescents with DS (mean age 14.45 +/- 1.22 years) were randomized to the VR-AE, TAE, or control group (CG). Both intervention groups completed 20 supervised sessions over 10 weeks. VR-AE involved Xbox Kinect-based exergaming, while TAE consisted of treadmill training. Physical fitness, functional capacity, QoL, physical activity, and enjoyment were assessed at baseline and post-intervention. RESULTS: Both VR-AE and TAE improved selected anthropometric measures compared with CG (p < 0.05). VR-AE demonstrated greater improvements in flexibility, handgrip strength, and trunk endurance (p < 0.05), whereas TAE produced greater improvements in functional capacity and mobility (p < 0.05). Anthropometric improvements were comparable between intervention groups. CONCLUSIONS: VR-AE and TAE showed different patterns of short-term improvement in adolescents with DS. Whilst these findings should be interpreted cautiously given the relatively small sample size and 10-week intervention period, they highlight the potential for supervised VR-AE and TAE to serve as practical exercise options that can be tailored to individual rehabilitation goals and preferences. FAU - Kostanoglu, Alis AU - Kostanoglu A AUID- ORCID: 0000-0002-6912-9836 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey. FAU - Durgut, Elif AU - Durgut E AUID- ORCID: 0000-0003-2000-1708 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey. FAU - Sevinc Gunduz, Merve AU - Sevinc Gunduz M AUID- ORCID: 0000-0002-0443-2295 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey. FAU - Arslanturk Yildirim, Ayca AU - Arslanturk Yildirim A AUID- ORCID: 0000-0002-2535-6631 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey. FAU - Torpu, Gokhan Can AU - Torpu GC AUID- ORCID: 0009-0004-5400-272X AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Halic University, Istanbul, Turkey. AD - Department of Cardiopulmonary Physiotherapy and Rehabilitation, Institute of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey. FAU - Orengul, Abdurrahman Cahid AU - Orengul AC AUID- ORCID: 0000-0002-4720-6167 AD - Department of Child and Adolescent Psychiatry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260926 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM OAB - Preliminary findings suggest that both virtual reality-based and traditional aerobic exercise may be considered as supervised exercise options for adolescents with Down syndrome.A twice-weekly, 10-week supervised exercise program may be feasible for delivering aerobic exercise in this population.Virtual reality-based aerobic exercise may provide an engaging alternative to conventional exercise when exercise enjoyment and participation are rehabilitation priorities.Exercise modality should be selected according to individual rehabilitation goals, preferences, and available resources. OABL- eng OTO - NOTNLM OT - Down syndrome OT - aerobic exercise OT - exergaming OT - physical function OT - rehabilitation EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:35 CRDT- 2026/09/26 03:13 PHST- 2026/09/26 05:35 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 03:13 [entrez] AID - 10.1080/09638288.2026.2735453 [doi] PST - aheadofprint SO - Disabil Rehabil. 2026 Sep 26:1-16. doi: 10.1080/09638288.2026.2735453. PMID- 42798108 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260930 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 39 DP - 2026 Sep 25 TI - Research hotspots and emerging trends of pain neuroscience education in chronic pain management: A bibliometric visualization study. PG - e50742 LID - 10.1097/MD.0000000000050742 [doi] LID - e50742 AB - OBJECTIVE: Chronic pain is a major global public health concern. Pain neuroscience education (PNE), a cognitive intervention grounded in the biopsychosocial model, has been increasingly applied to chronic pain management. However, its knowledge structure and research evolution have not been systematically delineated. This bibliometric study aimed to map the research landscape, identify hot topics and emerging trends, and provide evidence for clinical translation and research planning. METHODS: Publications on PNE in chronic pain were retrieved from the Web of Science Core Collection (2015-2026). A total of 409 articles were analyzed using Microsoft Excel, CiteSpace, VOSviewer, Bibliometrix, and SCImago Graphica to examine publication outputs, collaboration networks, keyword co-occurrence, clustering, burst detection, and citation patterns. RESULTS: Annual publications increased rapidly from 2018 to 2024, peaking in 2024. The United States, Spain, and Belgium were the most productive countries, with strong collaboration between North America and Europe, while Asian and low-and middle-income countries remained peripheral. Jo Nijs team was a central research force. Keyword analysis revealed 3 hotspots: predominant focus on chronic musculoskeletal pain; a shift from single PNE to multimodal regimens combining exercise and cognitive behavioral therapy; methodological validation of assessment tools serving as a critical hub linking research branches. Burst analysis indicated a transition from empirical accumulation to evidence synthesis with personalized interventions for older adults and adolescents as future frontiers. CONCLUSION: PNE research is advancing rapidly, shifting from efficacy validation toward implementation science and precision interventions. Current research shows a geographic imbalance; future efforts should enhance cross-regional knowledge translation. This study provides a clear knowledge map for researchers and evidence-based directions for optimizing pain management systems. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Chen, Yixin AU - Chen Y AD - School of Nursing, Inner Mongolia Medical University, No. 5 Xinhua Street, Hohhot, Inner Mongolia Autonomous Region, China. FAU - Yu, Huamei AU - Yu H AD - Department of Nursing, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot, Inner Mongolia Autonomous Region, China. FAU - Dang, Lixian AU - Dang L AD - School of Nursing, Inner Mongolia Medical University, No. 5 Xinhua Street, Hohhot, Inner Mongolia Autonomous Region, China. FAU - Li, Lingling AU - Li L AD - School of Nursing, Inner Mongolia Medical University, No. 5 Xinhua Street, Hohhot, Inner Mongolia Autonomous Region, China. FAU - Li, Chenyang AU - Li C AD - Department of Nursing, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot, Inner Mongolia Autonomous Region, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - *Chronic Pain/therapy MH - Humans MH - *Neurosciences/education MH - *Pain Management/methods MH - *Bibliometrics PMC - PMC13619212 OTO - NOTNLM OT - CiteSpace OT - chronic pain OT - pain neuroscience education OT - research hotspots OT - visualization analysis COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/25 CRDT- 2026/09/26 01:18 PHST- 2026/06/10 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:18 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 00005792-202609250-00078 [pii] AID - MD-D-26-08842 [pii] AID - 10.1097/MD.0000000000050742 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Sep 25;105(39):e50742. doi: 10.1097/MD.0000000000050742. PMID- 42797089 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 21 TI - Domain-Dependent Performance of Human Experts and AI Systems in Pediatric Menu Evaluation. LID - 10.3390/nu18183106 [doi] LID - 3106 AB - BACKGROUND/OBJECTIVES: Artificial intelligence (AI) tools are increasingly used for dietary assessment, but their reliability in pediatric nutrition remains uncertain. This study compared AI systems and human evaluators in pediatric menu assessment against expert-defined reference ratings. METHODS: This observational cross-sectional study used anonymized dietary and clinical information from three healthy pediatric cases. A multidisciplinary panel of pediatric nutrition specialists established standard evaluations. Assessments were completed by 84 AI evaluations, 116 nutrition specialists, 56 pediatric-focused physicians, and 88 physicians from other specialties. Outcomes included absolute error in total energy estimation, deviations in portion and qualitative ratings, standardized scores, and binary adequacy accuracy. Groups were compared using ANOVA or Kruskal-Wallis tests with post hoc analyses. RESULTS: A total of 344 assessments were included. Energy-estimation error differed between groups (Kruskal-Wallis = 12.85, p = 0.0016), but this analysis was based on a limited and highly unbalanced subset of 77 assessments. AI had the largest mean absolute error (260.3 +/- 194.3 kcal), followed by nutrition specialists (148.4 +/- 81.5 kcal); physicians with other specialties had the lowest error (60.4 +/- 53.3 kcal); these subgroup comparisons should be interpreted cautiously because of the small and unequal numbers of available energy estimates. AI showed greater portion-rating deviation (0.488; 95% CI: 0.38-0.60) than nutrition specialists (0.310; 95% CI: 0.20-0.42; p = 0.0019, q = 0.0059) and pediatric-focused physicians (0.286; 95% CI: 0.16-0.41; p = 0.0181, q = 0.019). Conversely, AI showed the lowest deviations for variety (0.37 +/- 0.49) and processing (0.33 +/- 0.47), compared with 1.15-1.36 and 1.22-1.57, respectively, among human groups (both p = 0.0001). CONCLUSIONS: AI may support structured pediatric menu screening for descriptive qualitative features; however, lower precision for energy and portion assessment supports, under these specific conditions, its use as an adjunct, for qualified nutrition professionals. FAU - Martin-Hadmas, Roxana Maria AU - Martin-Hadmas RM AUID- ORCID: 0000-0003-1499-5398 AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Sovea, Rebeca AU - Sovea R AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Pol, Diana AU - Pol D AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Gavra, George Mihaita AU - Gavra GM AUID- ORCID: 0009-0007-9594-1231 AD - Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania. FAU - Tarcea, Monica AU - Tarcea M AUID- ORCID: 0000-0001-7299-118X AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Neghirla, Adriana AU - Neghirla A AD - Mures School Medicine Association, 540233 Targu Mures, Romania. FAU - Martin, Stefan Adrian AU - Martin SA AD - Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania. LA - eng PT - Journal Article PT - Observational Study DEP - 20260921 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Artificial Intelligence MH - *Nutrition Assessment MH - Child MH - Female MH - Reproducibility of Results MH - Energy Intake MH - Male MH - *Menu Planning MH - Pediatrics MH - Nutritionists PMC - PMC13610824 OTO - NOTNLM OT - artificial intelligence OT - clinical decision support OT - dietary assessment OT - energy estimation OT - large language models OT - menu evaluation OT - nutrition professionals OT - pediatric nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/21 CRDT- 2026/09/26 01:15 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - nu18183106 [pii] AID - nutrients-18-03106 [pii] AID - 10.3390/nu18183106 [doi] PST - epublish SO - Nutrients. 2026 Sep 21;18(18):3106. doi: 10.3390/nu18183106. PMID- 42797068 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 20 TI - Iodine Nutrition, Non-Genetic Factors, and Two Candidate Polymorphisms Associated with Thyroid Function Abnormalities Among Children Aged 8-10 Years in Iodine-Adequate Areas of Tianjin, China. LID - 10.3390/nu18183085 [doi] LID - 3085 AB - Background/Objectives: As dietary and environmental exposures change, interacting with genetic susceptibility, the prevalence of thyroid function abnormality and subclinical thyroid dysfunction in children is rising, yet systematic research in this population remains scarce. Methods: From 13 districts of Tianjin, China, all characterized by adequate iodine levels, 997 children between the ages of 8-10 years were recruited using a school-based sampling approach. Peripheral venous blood samples were drawn for genotyping analysis of two single nucleotide polymorphisms (SNPs): thyroid stimulating hormone receptor (TSHR) rs2268458 and NK2 homeobox 1 (NKX2-1) rs2076735 using the Sequenom MassARRAY platform. In addition, data on 31 non-genetic factors, including urinary iodine concentration (UIC), were collected. Restricted cubic spline (RCS) models were used to examine the non-linear associations between UIC and thyroid abnormalities. Multivariable Poisson regression was applied to identify factors associated with thyroid outcomes. Results: The overall prevalence of thyroid function abnormality in the study population was 17.35%, with detection rates of 3.51% for subclinical hyperthyroidism and 2.21% for subclinical hypothyroidism. After adjusting for age, sex, body mass index z-score (BMI-z-score), district of residence, and recruitment year, RCS models revealed significant U-shaped non-linear associations between UIC and both free triiodothyronine (FT(3)) abnormality (P(overall) = 0.003, P(nonlinear) < 0.001) and overall thyroid function abnormality (P(overall) = 0.042, P(nonlinear) = 0.029). In multivariable analysis, after Bonferroni correction within prespecified hypothesis families, family history of thyroid disease in first-degree relatives remained significantly associated with subclinical hyperthyroidism (adjusted p = 0.015), and UIC < 100 mug/L remained significantly associated with overall thyroid function abnormality (adjusted p = 0.036). In addition, district of residence was associated with subclinical hypothyroidism after correction (adjusted p = 0.009). Stratified analyses revealed potential subgroup-specific effects. Children with the NKX2-1 rs2076735 TT + TC genotype and UIC < 100 mug/L had a higher prevalence of thyroid function abnormality compared with the reference group (UIC 100-299 mug/L) (p = 0.031, PR = 3.093, 95% CI: 1.108, 8.636). Frequent consumption of kelp or laver soup was associated with a higher prevalence of subclinical hyperthyroidism among children with the NKX2-1 rs2076735 CC genotype or the TSHR rs2268458 TT genotype (p = 0.049, PR = 3.636, 95% CI: 1.006, 13.140; p = 0.023, PR = 4.814, 95% CI: 1.245, 18.610, respectively). Among children with the NKX2-1 rs2076735 CC genotype, those with a family history of thyroid disease had a higher prevalence of subclinical hyperthyroidism (p = 0.029, PR = 4.114, 95% CI: 1.152, 14.688). After Benjamini-Hochberg false discovery rate correction, none of the subgroup-specific associations remained statistically significant (adjusted p-values: 0.058-0.065). Conclusions: The prevalence of thyroid function abnormality and subclinical thyroid dysfunction was relatively high among school-aged children in this study population from Tianjin, China. After adjustment for covariates and correction for multiple comparisons, family history of thyroid disease, UIC < 100 mug/L, and district of residence remained significantly associated with subclinical hyperthyroidism, overall thyroid function abnormality, and subclinical hypothyroidism, respectively. A U-shaped association was observed between UIC and thyroid health, highlighting the importance of maintaining adequate iodine nutrition. However, stratified analyses suggested potential subgroup-specific associations that require validation in larger, independent cohorts. FAU - Duan, Yani AU - Duan Y AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Wang, Yang AU - Wang Y AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Li, Fang AU - Li F AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Li, Wenfeng AU - Li W AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Zhang, Dandan AU - Zhang D AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Cui, Yushan AU - Cui Y AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. LA - eng GR - TJWJ2024QN091/Tianjin Health Research Project/ GR - 82173641/National Natural Science Foundation of China/ GR - TJYXZDXK-3-020B/Tianjin Key Medical Discipline Construction/ PT - Journal Article DEP - 20260920 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 9679TC07X4 (Iodine) RN - 0 (Receptors, Thyrotropin) RN - 0 (Thyroid Nuclear Factor 1) RN - 0 (TSHR protein, human) SB - IM MH - Humans MH - *Iodine/urine/administration & dosage/deficiency MH - China/epidemiology MH - Child MH - Female MH - Male MH - *Polymorphism, Single Nucleotide MH - Hyperthyroidism/genetics/epidemiology MH - *Thyroid Gland/physiopathology MH - *Receptors, Thyrotropin/genetics MH - Prevalence MH - Genetic Predisposition to Disease MH - *Hypothyroidism/genetics/epidemiology MH - *Nutritional Status MH - *Thyroid Nuclear Factor 1/genetics MH - *Thyroid Diseases/genetics/epidemiology MH - Thyroid Function Tests PMC - PMC13610479 OTO - NOTNLM OT - Iodine status OT - NKX2-1 OT - TSHR OT - children OT - subclinical thyroid dysfunction OT - thyroid function abnormality COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/20 CRDT- 2026/09/26 01:15 PHST- 2026/08/12 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/20 00:00 [pmc-release] AID - nu18183085 [pii] AID - nutrients-18-03085 [pii] AID - 10.3390/nu18183085 [doi] PST - epublish SO - Nutrients. 2026 Sep 20;18(18):3085. doi: 10.3390/nu18183085. PMID- 42797056 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 20 TI - Pro-Inflammatory Dietary Profiles Are Associated with Psychosocial Functioning in Spanish Adolescents: Findings from the EHDLA Study. LID - 10.3390/nu18183073 [doi] LID - 3073 AB - Background: Dietary factors may influence psychosocial outcomes through inflammatory pathways, but evidence in adolescents remains limited. The aim was to examine whether dietary inflammatory potential is associated with psychosocial functioning among Spanish adolescents. Methods: This cross-sectional study is based on a subsample from the Eating Healthy and Daily Life Activities (EHDLA) project, conducted in the Region of Murcia (Spain). Dietary inflammatory potential was assessed using a dietary inflammatory index (DII)-informed Food Frequency Questionnaire (FFQ)-derived inflammatory score based on a validated 45-item food frequency questionnaire. Behavioral functioning was evaluated using the Strengths and Difficulties Questionnaire (SDQ). Associations between DII-informed FFQ-derived inflammatory scores and SDQ outcomes were examined using robust linear regression models adjusted for sociodemographic, lifestyle, and anthropometric factors. Results: The analysis included 674 adolescents (57.1% girls; age: 14.0 [13.0-15.0] years). Higher DII-informed FFQ-derived inflammatory score (more pro-inflammatory diet) was associated with greater total behavioral difficulties (unstandardized beta coefficient [B] = 0.058; 95% confidence interval [CI]: 0.005-0.111; standardized beta = 0.099), conduct problems (B = 0.025; 95% CI: 0.011-0.039; beta = 0.148), hyperactivity/inattention (B = 0.032; 95% CI: 0.013-0.052; beta = 0.154), and externalizing problems (B = 0.056; 95% CI: 0.028-0.084; beta = 0.181), and with lower prosocial behavior (B = -0.029; 95% CI: -0.045 to -0.014; beta = -0.149). Multiple imputation sensitivity analyses yielded estimates in a similar direction, although the associations did not reach statistical significance. No significant associations were observed for emotional symptoms, peer relationship problems, or internalizing difficulties. Conclusions: Higher dietary inflammatory potential was associated with a less favorable psychosocial functioning profile among adolescents, particularly in externalizing domains. Longitudinal studies and anti-inflammatory dietary interventions are needed to determine whether the observed associations translate into meaningful changes in psychosocial functioning. FAU - Marrero-Fernandez, Paula AU - Marrero-Fernandez P AUID- ORCID: 0009-0009-0031-0408 AD - Department of Chemical Engineering and Pharmaceutical Technology, University of La Laguna, Avda. Astrofisico Francisco Sanchez s/n, 38001 Santa Cruz de Tenerife, Spain. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AUID- ORCID: 0000-0002-0210-2866 AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. FAU - Mino, Camila AU - Mino C AUID- ORCID: 0000-0002-9444-8564 AD - European Institute of Higher Studies (IEES), 4820-509 Fafe, Portugal. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco 4810101, Chile. FAU - Lopez-Moreno, Miguel AU - Lopez-Moreno M AUID- ORCID: 0000-0003-0553-6210 AD - Diet, Planetary Health and Performance, Faculty of Health Sciences, Universidad Francisco de Vitoria, 28223 Madrid, Spain. AD - Institute of Health and Sport Sciences, Faculty of Health Science, Universidad Francisco de Vitoria, 28223 Madrid, Spain. LA - eng PT - Journal Article DEP - 20260920 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - Spain/epidemiology MH - Cross-Sectional Studies MH - Male MH - *Inflammation/psychology/etiology MH - *Diet/adverse effects MH - *Psychosocial Functioning MH - *Adolescent Behavior/psychology MH - Surveys and Questionnaires MH - Feeding Behavior PMC - PMC13610942 OTO - NOTNLM OT - adolescents OT - behavioral problems OT - diet-related inflammation OT - dietary inflammatory index OT - psychosocial functioning OT - strengths and difficulties questionnaire COIS- ML-M reports having previously received remuneration from Danone and Foods For Tomorrow for advisory board participation and consulting activities. These activities were unrelated to the submitted work and are not ongoing. At present, he has no active financial relationships with these entities. All other authors reported no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/20 CRDT- 2026/09/26 01:15 PHST- 2026/08/06 00:00 [received] PHST- 2026/09/08 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/20 00:00 [pmc-release] AID - nu18183073 [pii] AID - nutrients-18-03073 [pii] AID - 10.3390/nu18183073 [doi] PST - epublish SO - Nutrients. 2026 Sep 20;18(18):3073. doi: 10.3390/nu18183073. PMID- 42797036 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 18 TI - Dietary Approaches in Eosinophilic Esophagitis. LID - 10.3390/nu18183053 [doi] LID - 3053 AB - Eosinophilic esophagitis (EoE) is a chronic, immune-mediated, non-IgE-mediated food allergy and a leading cause of dysphagia and food impaction in adults, with rising prevalence worldwide. Diagnosis requires >/=15 eosinophils per high-power field on esophageal biopsy after exclusion of other causes of gastrointestinal eosinophilia. Food allergens, principally milk, wheat, eggs, legumes and seafood, drive the inflammatory process, and treatment options include proton pump inhibitors, topical corticosteroids, biologic agents and endoscopic dilation for stricturing disease. Among these, dietary therapy is the only approach that removes the causative trigger rather than suppressing the inflammatory response, making drug-free, sustained remission achievable. Elemental diets achieve the highest histological remission rates but are poorly tolerated in practice; empiric elimination following a step-up strategy, starting with one or two foods and escalating in the absence of response, is more practical for most adults. Conventional allergy testing cannot reliably identify food triggers in EoE and is not recommended for this purpose. Reintroduction of the trigger food leads to relapse, making long-term adherence essential, and not all patients are suitable candidates: repeated endoscopy, dietary restriction, quality of life impact and the risk of avoidant restrictive food intake disorder (ARFID) are barriers that must be weighed before recommending this approach. This review summarizes the available dietary approaches in adult and adolescent EoE, covering empiric elimination strategies and their efficacy, allergy test-directed diets, patient selection, the role of diet alongside other treatments, and nutritional adequacy and adherence. FAU - Arraf, Tarek AU - Arraf T AUID- ORCID: 0009-0001-5116-4254 AD - Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128 Padua, Italy. AD - Faculty of Medicine, Technion Institute of Technology, Haifa 3525433, Israel. AD - Department of Gastroenterology, Rambam Health Care Campus, Haifa 3109601, Israel. FAU - Chahuan, Javier AU - Chahuan J AUID- ORCID: 0000-0003-1261-6200 AD - Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128 Padua, Italy. AD - Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 8330077, Chile. FAU - Bertin, Luisa AU - Bertin L AUID- ORCID: 0009-0001-9816-4171 AD - Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128 Padua, Italy. FAU - Di Lecce, Gianni AU - Di Lecce G AUID- ORCID: 0009-0009-3553-6749 AD - Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128 Padua, Italy. FAU - Sirinic, Emma AU - Sirinic E AD - Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128 Padua, Italy. FAU - Savarino, Edoardo Vincenzo AU - Savarino EV AUID- ORCID: 0000-0002-3187-2894 AD - Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128 Padua, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260918 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Allergens) SB - IM MH - Humans MH - *Eosinophilic Esophagitis/diet therapy/diagnosis MH - *Food Hypersensitivity/diet therapy/complications/diagnosis MH - Elimination Diets MH - Adult MH - *Diet MH - Allergens MH - Adolescent PMC - PMC13610755 OTO - NOTNLM OT - dietary therapy OT - elemental diet OT - eosinophilic esophagitis OT - food allergy OT - one-food elimination diet COIS- Tarek Arraf, Javier Chahuan, Gianni Di Lecce and Emma Sirinic have nothing to declare. Edoardo Vincenzo Savarino has served as a speaker for AbbVie, Agave, AGPharma, Alfasigma, Aurora Pharma, CaDiGroup, Celltrion, Dr. Falk, EG Stada Group, Fenix Pharma, Fresenius Kabi, Galapagos, Janssen, JB Pharmaceuticals, Innovamedica/Adacyte, Malesci, MayolyBiohealth, Omega Pharma, Pfizer, Reckitt Benckiser, Sandoz, SILA, Sofar, Takeda, Tillots, and Unifarco; has served as consultant for AbbVie, Agave, Alfasigma, Biogen, Bristol-Myers Squibb, Celltrion, Diadema Farmaceutici, Dr. Falk, Fenix Pharma, Fresenius Kabi, Janssen, JB Pharmaceuticals, Merck & Co, Nestle, Reckitt Benckiser, Regeneron, Sanofi, SILA, Sofar, Synformulas GmbH, Takeda, and Unifarco; and has received research support from Pfizer, Reckitt Benckiser, SILA, Sofar, Unifarco, and Zeta Farmaceutici. Luisa Bertin has served as a speaker for Takeda Spa, Edra Spa and Giuliani. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/18 CRDT- 2026/09/26 01:15 PHST- 2026/08/20 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - nu18183053 [pii] AID - nutrients-18-03053 [pii] AID - 10.3390/nu18183053 [doi] PST - epublish SO - Nutrients. 2026 Sep 18;18(18):3053. doi: 10.3390/nu18183053. PMID- 42797034 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260930 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 18 TI - Dietary Behaviours Mediate Intervention Effects on Body Composition Outcomes in Children: Evidence from a Cluster-Randomised Controlled Trial. LID - 10.3390/nu18183051 [doi] LID - 3051 AB - BACKGROUND/OBJECTIVES: Few paediatric obesity trials have examined behavioural mediators of intervention effects on detailed body composition outcomes beyond body mass index (BMI). Given the complexity of multiple correlated body composition indicators, this study aimed to employ principal component analysis (PCA) to derive a composite adiposity factor and to apply mediation analysis to identify whether changes in dietary behaviours and physical activity mediated the effects of the DECIDE-Children intervention on body composition. METHODS: This study included 1180 children from a 9-month cluster-randomised controlled trial that delivered a multifaceted, digitally assisted intervention targeting children (health education, physical activity reinforcement, and app-based BMI monitoring/feedback) and their environments (school food policies and family engagement). Outcomes were changes in body composition (whole-body and trunk fat mass, fat-free mass, and muscle mass indices measured by bioelectrical impedance analysis). Potential mediators included changes in dietary behaviour, screen time, and moderate-to-vigorous physical activity (MVPA), assessed via validated questionnaires. PCA was used to reduce the dimensionality of body composition variables and to derive a composite adiposity factor (PCA_1), with higher values indicating greater adiposity and lower muscle mass. Mediation was tested using linear mixed-effects models adjusted for age, sex, and region. RESULTS: The intervention significantly reduced adiposity indicators (e.g., whole-body and trunk fat mass percentage decreased by 1.003%, and PCA_1 decreased by 0.942 SD) and concurrently increased fat-free mass percentage and muscle mass percentage at both whole-body and trunk levels. Dietary behaviour significantly mediated the intervention effects on all body composition outcomes (e.g., mediating 16.1% of the effect on PCA_1), whereas physical activity (both screen time and MVPA) showed no mediation. Sensitivity analyses supported the primary findings. CONCLUSIONS: The DECIDE-Children intervention improved body composition by reducing adiposity and increasing fat-free and muscle mass percentage, effects primarily mediated by dietary behaviour. These findings highlight dietary behaviour as a key component in paediatric obesity intervention. FAU - Zhang, Li AU - Zhang L AUID- ORCID: 0000-0002-0367-0419 AD - Clinical Research Center for Children's Health and Diseases, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China. FAU - Wang, Lu AU - Wang L AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Yin, Chun-Jie AU - Yin CJ AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Duan, Yu-Qi AU - Duan YQ AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Ma, Jiaolong AU - Ma J AD - School of Public Health, Shihezi University, Shihezi 832000, China. FAU - Yan, Shi-Yu AU - Yan SY AUID- ORCID: 0009-0003-4067-9652 AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Chin, Yit Siew AU - Chin YS AUID- ORCID: 0000-0002-7609-1944 AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia. FAU - Li, Yan AU - Li Y AUID- ORCID: 0000-0003-2233-7061 AD - Clinical Research Center for Children's Health and Diseases, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China. FAU - Wang, Hai-Jun AU - Wang HJ AUID- ORCID: 0000-0003-0849-2903 AD - School of Public Health, Shihezi University, Shihezi 832000, China. AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. LA - eng GR - Z20243204/Shandong Province Traditional Chinese Medicine Science and Technology Project/ GR - SFYZXET-202501/Shandong Maternal and Child Health Association Child Growth and Development Medical Research Project/ GR - 2016YFC1300204/National Key R&D Program of China/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260918 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - *Body Composition MH - Exercise MH - *Feeding Behavior MH - Adiposity MH - Body Mass Index MH - *Pediatric Obesity/prevention & control/therapy MH - Principal Component Analysis MH - *Diet MH - *Health Behavior MH - Cluster Analysis PMC - PMC13610272 OTO - NOTNLM OT - body composition OT - children OT - dietary behaviour OT - mediation analysis OT - obesity OT - principal component analysis OT - randomised controlled trial COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/18 CRDT- 2026/09/26 01:15 PHST- 2026/07/24 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - nu18183051 [pii] AID - nutrients-18-03051 [pii] AID - 10.3390/nu18183051 [doi] PST - epublish SO - Nutrients. 2026 Sep 18;18(18):3051. doi: 10.3390/nu18183051. PMID- 42797003 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 16 TI - Dried Blood Spot-Based Monitoring of Dietary Treatment in Children, Adolescents, and Young Adults with Inherited Disorders of Amino Acid Metabolism: A Four-Year Pilot Study. LID - 10.3390/nu18183020 [doi] LID - 3020 AB - Background: Regular biochemical monitoring is essential for the safe and effective dietary treatment of inherited disorders of amino acid metabolism. However, conventional venous blood sampling may limit monitoring frequency and increase the burden on families. This study evaluated the feasibility and clinical usefulness of home-collected dried blood spot (DBS) samples analyzed using tandem mass spectrometry and additional chromatographic methods for dietary monitoring in inherited disorders of amino acid metabolism other than phenylketonuria. Methods: Between 2022 and 2025, children, adolescents, and young adults aged between 4 months and 20.5 years who were followed at a national metabolic center were monitored using DBS samples. The initial cohort included patients with maple syrup urine disease, tyrosinemia type III, homocystinuria, glutaric aciduria type 1, methylmalonic aciduria, isovaleric aciduria, argininosuccinic aciduria, methionine adenosyltransferase I/III deficiency, beta-ketothiolase deficiency, propionic aciduria, gyrate atrophy, and citrullinemia type 1. Disease-specific amino acids and metabolites were assessed to guide individualized dietary recommendations. Results: The number of monitored patients ranged from 24 to 40 per year. Overall annual completion rates of planned DBS measurements ranged from 56.7% to 73.0%, with additional clinically indicated samples collected in selected patients. DBS monitoring detected abnormal metabolite concentrations and supported dietary interventions, particularly in maple syrup urine disease, glutaric aciduria type 1, homocystinuria, tyrosinemia type III, and MAT I/III deficiency. In several other disorders, routine monthly DBS monitoring showed limited additional clinical value. Conclusions: DBS-based monitoring is a feasible approach that may support individualized dietary management in selected inherited disorders of amino acid metabolism, especially in early childhood and during periods of increased metabolic risk. FAU - Kowalik, Agnieszka AU - Kowalik A AUID- ORCID: 0000-0002-7368-3901 AD - Department of Inborn Errors of Metabolism and Pediatrics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Glab-Jablonska, Ewa AU - Glab-Jablonska E AUID- ORCID: 0000-0002-8061-0049 AD - Department of Metabolic Screening and Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Taybert, Joanna AU - Taybert J AUID- ORCID: 0000-0002-3352-2126 AD - Department of Inborn Errors of Metabolism and Pediatrics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Nogalska, Marta AU - Nogalska M AD - Department of Inborn Errors of Metabolism and Pediatrics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Sasin-Rokita, Mariola AU - Sasin-Rokita M AUID- ORCID: 0009-0008-3459-7534 AD - Department of Metabolic Screening and Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Chelchowska, Magdalena AU - Chelchowska M AUID- ORCID: 0000-0002-6174-6813 AD - Department of Metabolic Screening and Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Myszkowska-Ryciak, Joanna AU - Myszkowska-Ryciak J AUID- ORCID: 0000-0001-7167-1993 AD - Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), 02-776 Warsaw, Poland. FAU - Sykut-Cegielska, Jolanta AU - Sykut-Cegielska J AUID- ORCID: 0000-0003-0762-3721 AD - Department of Inborn Errors of Metabolism and Pediatrics, Institute of Mother and Child, 01-211 Warsaw, Poland. LA - eng PT - Journal Article DEP - 20260916 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Amino Acids) SB - IM MH - Humans MH - Pilot Projects MH - Adolescent MH - *Amino Acid Metabolism, Inborn Errors/diet therapy/blood/diagnosis MH - Female MH - Child MH - Child, Preschool MH - Male MH - Infant MH - *Amino Acids/blood/metabolism MH - *Dried Blood Spot Testing/methods MH - Young Adult MH - Tandem Mass Spectrometry MH - Feasibility Studies PMC - PMC13610832 OTO - NOTNLM OT - amino acid metabolism disorders OT - dietary treatment monitoring OT - dried blood spot OT - inborn errors of metabolism OT - metabolic control OT - tandem mass spectrometry COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/16 CRDT- 2026/09/26 01:15 PHST- 2026/06/25 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - nu18183020 [pii] AID - nutrients-18-03020 [pii] AID - 10.3390/nu18183020 [doi] PST - epublish SO - Nutrients. 2026 Sep 16;18(18):3020. doi: 10.3390/nu18183020. PMID- 42796999 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 15 TI - Tibetan Butter Tea Consumption and Cognitive Performance Among Tibetan Adolescents at High Altitude. LID - 10.3390/nu18183017 [doi] LID - 3017 AB - Background: Tibetan butter tea sits at a tension between the health concerns raised by its high salt and fat content and the potential cognitive benefits of its tea-derived constituents, yet whether this traditional beverage is associated with cognition in high-altitude Tibetan adolescents has not been directly examined. Methods: We conducted a school-based cross-sectional study of Tibetan students in grades 7-12 in Lhasa, Xizang, China, between June 2024 and June 2025. The analytic sample included 7967 students, with ages ranging from 10.18 to 24.82 years (mean +/- SD: 16.06 +/- 1.80). Butter tea consumption frequency was self-reported. Cognitive performance was assessed with Raven's Standard Progressive Matrices; low cognitive performance was defined as a score below the grade-specific 25th percentile. Logistic regression with cluster-robust standard errors estimated odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for demographic, family, socioeconomic, sleep, physical activity, and lifestyle factors, both overall and in sex-specific models. Results: Among 7967 Tibetan students, 3534 were male, and 4433 were female. Low cognitive performance was most prevalent among students reporting daily (29.56%) or never (26.34%) consumption and less prevalent among those reporting occasional (22.18%) or frequent (20.39%) consumption. Compared with never consumption, occasional consumption (aOR = 0.79; 95% CI, 0.70-0.88; p < 0.001) and frequent consumption (aOR = 0.71; 95% CI, 0.55-0.90; p = 0.004) were associated with lower odds of low cognitive performance. Daily consumption was not statistically significant. In sex-stratified analyses, frequent consumption was associated with lower odds among males (aOR = 0.68; 95% CI, 0.49-0.93; p = 0.018). Among females, both occasional (aOR = 0.76; 95% CI, 0.64-0.90; p = 0.001) and frequent (aOR = 0.74; 95% CI, 0.58-0.93; p = 0.011) consumption were associated with lower odds. Conclusions: Occasional and frequent consumption of Tibetan butter tea was associated with reduced odds of low cognitive performance among Tibetan adolescents at high altitude, with modest sex differences. These findings suggest that Tibetan butter tea should be evaluated as a culturally embedded whole-dietary exposure and may inform culturally sensitive school-based nutrition education and public health guidance in high-altitude Tibetan settings; however, causal inference cannot be established from this cross-sectional study, and longitudinal validation is needed. FAU - Deng, Liping AU - Deng L AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Fang, Yuhang AU - Fang Y AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. FAU - Pingcuo, Pingcuo AU - Pingcuo P AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Cirenyangzong, Cirenyangzong AU - Cirenyangzong C AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Zhao, Wenhu AU - Zhao W AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Zhao, Junmei AU - Zhao J AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Wang, Yanhui AU - Wang Y AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Xu, Simin AU - Xu S AUID- ORCID: 0000-0003-4853-7598 AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. FAU - Lian, Qiguo AU - Lian Q AUID- ORCID: 0000-0001-8307-0116 AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. LA - eng GR - XZ202301ZY0045G/Science and Technology Projects of Xizang Autonomous Region, China/ GR - XZ2023ZR-ZY25(Z)/Xizang Natural Science Foundation/ PT - Journal Article DEP - 20260915 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Tea) SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Tibet MH - *Altitude MH - *Cognition MH - Cross-Sectional Studies MH - *Tea MH - Child MH - Young Adult MH - Students PMC - PMC13610373 OTO - NOTNLM OT - Tibetan butter tea OT - Xizang OT - cognitive performance OT - high altitude OT - students COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/15 CRDT- 2026/09/26 01:15 PHST- 2026/07/16 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - nu18183017 [pii] AID - nutrients-18-03017 [pii] AID - 10.3390/nu18183017 [doi] PST - epublish SO - Nutrients. 2026 Sep 15;18(18):3017. doi: 10.3390/nu18183017. PMID- 42796989 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 14 TI - Retinal and Choroidal Vascular Changes Associated with Vitamin D Deficiency. LID - 10.3390/nu18183006 [doi] LID - 3006 AB - Vitamin D is involved in endothelial regulation, inflammatory control, oxidative stress responses, angiogenesis, and neurovascular homeostasis, providing a biological basis for its potential involvement in the retinal and choroidal circulation. This narrative review synthesizes evidence from studies investigating associations between serum 25-hydroxyvitamin D [25(OH)D] concentrations and ocular vascular parameters assessed using optical coherence tomography (OCT), OCT angiography (OCTA), and retinal vascular imaging. Evidence from adult and pediatric populations generally associated vitamin D deficiency (VDD) with lower vessel density in the superficial and deep capillary plexuses, altered retinal vascular caliber and foveal avascular zone morphology, and reduced choroidal thickness or vascularity. However, the direction and magnitude of retinal OCTA findings were inconsistent, and conventional retinal structural measurements frequently remained unchanged. Supplementation studies reported relatively consistent increases in choroidal thickness and vascularity, whereas retinal perfusion responses were limited. Preliminary studies suggested that correction of VDD might support a more sustained response to bevacizumab in diabetic macular edema and central retinal vein occlusion, although this effect was not demonstrated consistently across retinal vascular diseases. Lower 25(OH)D concentrations were also more frequent among patients with retinal vascular occlusions, but residual systemic vascular confounding limits causal interpretation. Overall, current evidence supports a biologically plausible association between vitamin D status and ocular microvascular health but does not establish causality, functional visual benefit, or a specific therapeutic indication for supplementation. Longitudinal multicenter studies and randomized trials using standardized imaging protocols, functional outcomes, biochemical confirmation of vitamin D correction, and validated automated image analysis are required to determine the clinical relevance and reversibility of these findings. FAU - Tarasi, Tudor Corneliu AU - Tarasi TC AUID- ORCID: 0009-0002-7275-4285 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Donica, Vlad Constantin AU - Donica VC AUID- ORCID: 0000-0002-8814-3932 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Cianga, Vlad-Andrei AU - Cianga VA AUID- ORCID: 0000-0003-3215-2562 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Anita, Dragos-Constantin AU - Anita DC AUID- ORCID: 0000-0001-5463-6651 AD - Ion Ionescu de la Brad Iasi University of Life Sciences, 700490 Iasi, Romania. FAU - Lazar, Mircea AU - Lazar M AUID- ORCID: 0000-0002-3876-8416 AD - Ion Ionescu de la Brad Iasi University of Life Sciences, 700490 Iasi, Romania. FAU - Tirnovanu, Stefan-Dragos AU - Tirnovanu SD AUID- ORCID: 0009-0006-2624-8890 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Branisteanu, Daciana Elena AU - Branisteanu DE AUID- ORCID: 0009-0004-5954-1159 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. AD - Department of Dermatology, Cai Ferate Clinical Hospital, 700506 Iasi, Romania. FAU - Alexa, Anisia Iuliana AU - Alexa AI AUID- ORCID: 0000-0002-4226-3779 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Branisteanu, Daniel-Constantin AU - Branisteanu DC AUID- ORCID: 0009-0009-5147-9596 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. AD - Department of Ophthalmology, Cai Ferate Clinical Hospital, 700506 Iasi, Romania. LA - eng GR - Grigore T. Popa University of Medicine and Pharmacy/ PT - Journal Article PT - Review DEP - 20260914 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - *Vitamin D Deficiency/complications/blood MH - Vitamin D/analogs & derivatives/blood MH - *Retinal Vessels/diagnostic imaging/pathology MH - Tomography, Optical Coherence MH - *Choroid/blood supply/diagnostic imaging MH - *Retinal Diseases/etiology MH - Child MH - Dietary Supplements MH - Adult PMC - PMC13610918 OTO - NOTNLM OT - choroidal vasculature OT - optical coherence tomography angiography OT - retinal microvasculature OT - vessel density OT - vitamin D deficiency COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/14 CRDT- 2026/09/26 01:15 PHST- 2026/08/10 00:00 [received] PHST- 2026/09/10 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - nu18183006 [pii] AID - nutrients-18-03006 [pii] AID - 10.3390/nu18183006 [doi] PST - epublish SO - Nutrients. 2026 Sep 14;18(18):3006. doi: 10.3390/nu18183006. PMID- 42796979 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 13 TI - Biochemical-Anthropometric Indices Assessing Liver Steatosis Identified in Elastography in Children with Metabolic DysFunction-Associated Steatotic Liver Disease. LID - 10.3390/nu18182996 [doi] LID - 2996 AB - Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of liver pathology in children. Hepatic fat content can be assessed by a transient elastography, but this method is not widely used. Therefore, the aim of this study was to evaluate the usefulness of a simple, surrogate biochemical-anthropometric indices of liver steatosis: FLI (Fatty Liver Index), HSI (Hepatic Steatosis Index), and LAP (Lipid Accumulation Product) in children with MASLD. Methods: The retrospective study included a group of 103 obese/overweight children. MASLD was diagnosed according to criteria developed by a multisociety statement published in Journal of Pediatric Gastroenterology and Nutrition in 2024. Liver steatosis (controlled attenuation parameter/CAP/) was assessed in elastography. HSI, FLI, and LAP were calculated according to their mathematical formulas. ROC analysis and multivariate logistic regression were performed to calculate the power of the studied indices in diagnostics of liver steatosis in children with MASLD. Results: MASLD was diagnosed in 72 children (70%). Children with MASLD had significantly higher levels of ALT, AST, GGT, uric acid, value of BMI, waist circumference, HOMA-IR, and indices HSI, FLI, LAP compared to the group of non-hepatopathic controls (n = 31). HSI, FLI, and LAP significantly correlated with CAP. All indices identified MASLD in the ROC analysis (AUC = 0.77, 0.76, 0.68 resp.). However, only HSI remained a significant independent predictor of hepatic steatosis in overweight/obese children. Conclusions: Although HSI, FLI, and LAP can be considered as useful biochemical-anthropometric indicators of MASLD in obese/overweight children, only HSI remained an independent predictor of hepatic steatosis in this group of children. FAU - Motkowska, Aleksandra M AU - Motkowska AM AD - Students' Scientific Association Affiliated with the Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Anna AU - Lebensztejn A AUID- ORCID: 0009-0006-2212-2588 AD - Students' Scientific Association Affiliated with the Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Tuchlinski, Bartosz AU - Tuchlinski B AD - Students' Scientific Association Affiliated with the Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Trochimczyk, Kinga AU - Trochimczyk K AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Flisiak-Jackiewicz, Marta AU - Flisiak-Jackiewicz M AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Bobrus-Chociej, Anna AU - Bobrus-Chociej A AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Rogalska, Magdalena AU - Rogalska M AD - Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Zurawia Street 14, 15-540 Bialystok, Poland. FAU - Cudowska, Beata AU - Cudowska B AUID- ORCID: 0000-0002-8062-5865 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Zdanowicz, Katarzyna AU - Zdanowicz K AUID- ORCID: 0000-0002-0755-911X AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Dariusz M AU - Lebensztejn DM AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. LA - eng GR - Grant No.: B.SUB.26.422/Medical University of Bialystok/ PT - Journal Article DEP - 20260913 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - Male MH - *Elasticity Imaging Techniques MH - Female MH - Retrospective Studies MH - *Fatty Liver/diagnosis/diagnostic imaging/etiology MH - Adolescent MH - *Anthropometry MH - Biomarkers/blood MH - ROC Curve MH - Liver/diagnostic imaging MH - Body Mass Index MH - Pediatric Obesity/complications PMC - PMC13609946 OTO - NOTNLM OT - children OT - controlled attenuation parameter OT - fatty liver index OT - hepatic steatosis index OT - lipid accumulation product OT - liver steatosis OT - metabolic dysfunction-associated steatotic liver disease OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/13 CRDT- 2026/09/26 01:14 PHST- 2026/08/10 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:14 [entrez] PHST- 2026/09/13 00:00 [pmc-release] AID - nu18182996 [pii] AID - nutrients-18-02996 [pii] AID - 10.3390/nu18182996 [doi] PST - epublish SO - Nutrients. 2026 Sep 13;18(18):2996. doi: 10.3390/nu18182996. PMID- 42796957 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261002 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 11 TI - High Ultra-Processed Food Consumption but No Association with Quality of Life in Saudi Children and Adolescents with ADHD. LID - 10.3390/nu18182977 [doi] LID - 2977 AB - BACKGROUND/OBJECTIVES: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. Dietary interventions can potentially control ADHD symptoms, providing a non-pharmacological approach that may improve the quality of life (QoL). This cross-sectional study aimed to assess the association between ultra-processed food intake (UPF) and QoL in children and adolescents with ADHD in Saudi Arabia. METHODS: A total of 128 participants (66% males and 33% females) diagnosed with ADHD, aged 8-18 years, were assessed. A validated Saudi food frequency questionnaire was used to assess dietary intake; the degree of food processing was assessed using a novel classification system. The health-related QoL was measured using the Pediatric Quality of Life Inventory. RESULTS: Both the child (57.83 +/- 18.12) and parent perspectives (57.97 +/- 16.09) of QOL scores were lower than those of healthy norms across all domains. (p-value < 0.0001). The UPF represented the largest proportion of total energy intake (48.76 +/- 13.40%), followed by unprocessed or minimally processed foods (39.80 +/- 13.35%). Parent- and child-reported QoL scores were strongly correlated (p < 0.0001); both were significantly lower than the healthy normative values across all domains (p < 0.0001). Higher parental educational attainment was associated with better QoL scores from both the child's and parents' perspectives (p = 0.049 and p = 0.023, respectively). CONCLUSIONS: Children and adolescents with ADHD demonstrated high consumption of UPF and significantly lower QoL scores than healthy norms. No significant association was observed between UPF intake and QoL scores. Further studies are needed to better understand the factors influencing dietary quality and QoL among children and adolescents with ADHD. FAU - Alwaili, Lina M AU - Alwaili LM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alsuhaibani, Norah S AU - Alsuhaibani NS AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alotaibi, Heton K AU - Alotaibi HK AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alkhudairy, Loujain A AU - Alkhudairy LA AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alanezi, Hana A AU - Alanezi HA AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Aljahdali, Abeer A AU - Aljahdali AA AUID- ORCID: 0000-0003-3104-1019 AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80215, Jeddah 21589, Saudi Arabia. AD - Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI 48109, USA. FAU - Alshamri, Dalal F AU - Alshamri DF AUID- ORCID: 0000-0003-1516-4705 AD - Department of Clinical Nutrition, King Abdullah bin Abdulaziz University Hospital, P.O. Box 84428, Riyadh 11564, Saudi Arabia. FAU - Alzaben, Abeer S AU - Alzaben AS AUID- ORCID: 0000-0001-9813-1524 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng GR - PNURSP2026R207/Princess Nourah bint Abdulrahman University/ PT - Journal Article DEP - 20260911 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Attention Deficit Disorder with Hyperactivity/psychology MH - *Quality of Life MH - Saudi Arabia MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Cross-Sectional Studies MH - *Eating/psychology MH - Diet Surveys MH - *Diet/adverse effects/statistics & numerical data MH - *Fast Foods/adverse effects/classification/statistics & numerical data PMC - PMC13610857 OTO - NOTNLM OT - NOVA OT - adolescents OT - attention-deficit hyperactivity disorder OT - quality of life OT - ultra-processed food COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/11 CRDT- 2026/09/26 01:14 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/05 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:14 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - nu18182977 [pii] AID - nutrients-18-02977 [pii] AID - 10.3390/nu18182977 [doi] PST - epublish SO - Nutrients. 2026 Sep 11;18(18):2977. doi: 10.3390/nu18182977. PMID- 42795970 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 18 DP - 2026 Sep 16 TI - Developmental Postural Modeling: A Historical and Conceptual Narrative Review of Posture Assessment. LID - 10.3390/jcm15187197 [doi] LID - 7197 AB - Background: Posture assessment has progressed from visual observation and descriptive classification to quantitative measurement, three-dimensional imaging, and artificial intelligence (AI)-assisted analyses. Despite these advances, uncertainty persists regarding normative interpretation, developmental significance, and prognosis, particularly during growth and maturation phases. Methods: This historical and conceptual narrative review synthesizes literature from PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, and Semantic Scholar, with additional citation tracking and targeted searches of historical monographs and foundational sources. The final literature search was completed on 30 May 2026. The review was narrative rather than systematic, and no formal risk-of-bias or evidence-quality appraisal was performed. Reporting and methodological transparency were strengthened by referencing the SANRA principles for narrative reviews. Results: The literature supports several overlapping methodological traditions: observation and classification, quantitative measurement, three-dimensional reconstruction, and automated image- and data-based analysis. These approaches have accumulated rather than replaced one another. Across these traditions, a persistent measurement-interpretation gap remains: postural configuration can be characterized by increasing precision, whereas developmental reference trajectories and prognostic interpretations remain limited. Conclusions: Developmental Postural Modeling (DPM) is proposed as a hypothesis-generating conceptual framework for future research, initially emphasizing posture during childhood and adolescence, when growth and maturation are most explicit. The DPM is not a validated clinical tool and does not currently provide individual predictions or treatment recommendations. Its proposed role is to organize future longitudinal research integrating morphology, function, development, environment, time, advanced imaging, and computational analysis. FAU - Glinkowski, Wojciech Michal AU - Glinkowski WM AUID- ORCID: 0000-0003-2602-1128 AD - Center of Excellence "TeleOrto" for Telediagnostics and Treatment of Disorders and Injuries of the Locomotor System, Department of Medical Informatics and Telemedicine, Medical University of Warsaw, 02-091 Warsaw, Poland. AD - Polish Telemedicine and eHealth Society, 03-728 Warsaw, Poland. FAU - Sitnik, Robert AU - Sitnik R AUID- ORCID: 0000-0002-8156-5462 AD - Faculty of Mechatronics, Warsaw University of Technology, ul. sw. Andrzeja Boboli 8, 02-525 Warsaw, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13607638 OTO - NOTNLM OT - anthropometry OT - artificial intelligence OT - auxology OT - body posture OT - developmental trajectories OT - postural development OT - posture classification OT - rasterstereography OT - spinal sagittal alignment OT - surface topography OT - three-dimensional reconstruction COIS- The authors declare no conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/16 CRDT- 2026/09/26 01:12 PHST- 2026/06/21 00:00 [received] PHST- 2026/08/17 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:12 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - jcm15187197 [pii] AID - jcm-15-07197 [pii] AID - 10.3390/jcm15187197 [doi] PST - epublish SO - J Clin Med. 2026 Sep 16;15(18):7197. doi: 10.3390/jcm15187197. PMID- 42795335 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 16 IP - 9 DP - 2026 Sep 2 TI - Inter-Rater Reliability of the Progressive Pain Check Method for Standardized Pain Assessment in Lipedema. LID - 10.3390/life16091471 [doi] LID - 1471 AB - BACKGROUND: Lipedema is a chronic progressive condition affecting approximately 10% of women, characterized by disproportionate subcutaneous adipose tissue accumulation and pain in the lower extremities. Standardized assessment methods for pain evaluation in lipedema remain limited. The Progressive Pain Check (PPC) method represents a potentially valuable tool for standardized pain assessment in lipedema patients. OBJECTIVE: To evaluate the inter-rater reliability of the PPC method for clinical assessment of evoked pain in lipedema patients. METHODS: Two independent assessors performed PPC evaluations. Inter-rater reliability was assessed using the Intraclass Correlation Coefficient [ICC(2,1), two-way random-effects, absolute agreement, single-measurement] with 95% confidence intervals (CI). RESULTS: This study included 429 women diagnosed with lipedema (mean age 41.2 +/- 11.5 years, mean disease duration 27.2 +/- 12.6 years). Patient characteristics revealed mean BMI of 29.5 +/- 6.9 kg/m(2), predominantly Type III lipedema presentation, and disease onset during adolescence (mean age 14 +/- 9.3 years). The PPC method demonstrated excellent inter-rater reliability between two independent assessors across all examined anatomical districts. CONCLUSIONS: The PPC method shows promise as a simple, repeatable, and standardized clinical tool for evoked pain assessment in lipedema patients. The demonstrated inter-rater reliability supports its potential utility in clinical practice. Further research is warranted to evaluate its intra-rater reliability, concurrent validity, and responsiveness in monitoring treatment effects. FAU - Patton, Laura AU - Patton L AUID- ORCID: 0009-0008-2024-4607 AD - Endocrinology and Lymphology Clinic, 38096 Vallelaghi, Italy. FAU - Ricolfi, Lorenzo AU - Ricolfi L AUID- ORCID: 0009-0000-7216-9612 AD - Endocrinology and Lymphology Clinic, 38096 Vallelaghi, Italy. FAU - Elhadidy, Heba Safwat Mhmoued Abdo AU - Elhadidy HSMA AUID- ORCID: 0000-0002-8425-8580 AD - Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Torino, Italy. FAU - Reverdito, Valeria AU - Reverdito V AD - Human Project Studio, 10138 Torino, Italy. FAU - Russotto, Antonino AU - Russotto A AUID- ORCID: 0000-0002-5925-2240 AD - Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Torino, Italy. FAU - Politano, Gianfranco AU - Politano G AUID- ORCID: 0000-0001-5268-9899 AD - Department of Control and Computer Engineering, Politecnico di Torino, 10129 Torino, Italy. FAU - Gianino, Maria Michela AU - Gianino MM AD - Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Torino, Italy. LA - eng PT - Journal Article DEP - 20260902 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC13608010 OTO - NOTNLM OT - allodynia OT - clinical OT - examination OT - inter-rater reliability OT - lipedema OT - pain assessment COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/02 CRDT- 2026/09/26 01:10 PHST- 2026/07/21 00:00 [received] PHST- 2026/08/29 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:10 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - life16091471 [pii] AID - life-16-01471 [pii] AID - 10.3390/life16091471 [doi] PST - epublish SO - Life (Basel). 2026 Sep 2;16(9):1471. doi: 10.3390/life16091471. PMID- 42794587 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 18 DP - 2026 Sep 13 TI - Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus? LID - 10.3390/ijms27188159 [doi] LID - 8159 AB - Childhood obesity is consistently associated with earlier pubertal timing, particularly in girls, whereas its relationship with true central precocious puberty (CPP), defined by premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, is less clearly established. An increased frequency of CPP diagnoses and referrals was reported during the COVID-19 pandemic, alongside changes in body weight, lifestyle, sleep, and psychosocial exposures. Human studies link excess adiposity to hyperleptinemia, insulin resistance, reduced adiponectin, altered sex-steroid bioavailability, and systemic low-grade inflammation, and associate these features with earlier pubertal development-consistently in girls, less so in boys. However, such associations do not establish that obesity directly induces premature hypothalamic activation. Mechanistic understanding of how these peripheral signals may influence pubertal timing derives predominantly from experimental models. The arcuate nucleus kisspeptin/neurokinin B/dynorphin (KNDy) network, a key component of the gonadotropin-releasing hormone (GnRH) pulse generator, interacts with hypothalamic metabolic circuits. In animal models of obesity and overnutrition, altered leptin and insulin signaling, mitochondrial reactive oxygen species generation, and activation of microglia and astrocytes remodel the mediobasal hypothalamus through inflammatory and stress-responsive pathways, including IKKbeta/NF-kappaB and JNK signaling and altered Nrf2-mediated antioxidant defenses. At the molecular level, metabolic status interacts with the epigenetic machinery governing Kiss1 expression: in rodent models of overnutrition, accelerated loss of SIRT1-mediated repression at the Kiss1 promoter facilitates pubertal activation. Human genetic evidence establishes MKRN3 and DLK1 as causes of familial CPP, but evidence that obesity modifies these pathways to induce sporadic CPP is insufficient. Similarly, gut microbial metabolites have been linked experimentally to pubertal timing, and antioxidant micronutrients such as selenium, zinc, and vitamins C and E may be altered in pediatric obesity, yet a specific role in CPP remains unproven. Collectively, current evidence supports a working model in which metabolic, inflammatory, redox, glial, and epigenetic pathways may converge on hypothalamic reproductive circuits to influence pubertal timing in susceptible children. Direct evidence in children with CPP-of hypothalamic oxidative stress, glial activation, Nrf2 dysfunction, SIRT1 remodeling, or microbiome-mediated activation-remains limited or absent. Lifestyle optimization is appropriate for improving metabolic health in children with obesity, whereas antioxidant, micronutrient, and microbiome-targeted interventions should be considered investigational with respect to CPP. Longitudinal pediatric studies that distinguish earlier pubertal timing from true CPP, and that integrate metabolic phenotyping with validated measures of HPG-axis activation, are needed to test this framework. FAU - Bizerea-Moga, Teofana-Otilia AU - Bizerea-Moga TO AUID- ORCID: 0000-0002-1599-5579 AD - Department XI of Pediatrics, First Pediatric University Clinic, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. FAU - Chisavu, Flavia AU - Chisavu F AD - Nephrology University Clinic, Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 4th Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. FAU - Chisavu, Lazar AU - Chisavu L AUID- ORCID: 0000-0003-3664-1945 AD - Nephrology University Clinic, Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - Nephrology Clinic, 'Pius Brinzeu' County Emergency Clinical Hospital, Liviu Rebreanu 156, 300723 Timisoara, Romania. FAU - Pitulice, Laura AU - Pitulice L AUID- ORCID: 0000-0002-5991-6203 AD - Department of Chemistry, West University of Timisoara, Pestallozi 16, 300115 Timisoara, Romania. AD - Institute of Advanced Environmental Research, Oituz 4c, 300086 Timisoara, Romania. FAU - Moga, Tudor Voicu AU - Moga TV AUID- ORCID: 0000-0002-8978-1856 AD - Department VII of Internal Medicine, Gastroenterology University Clinic, Advanced Regional Research Center in Gastroenterology and Hepatology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - Gastroenterology and Hepatology Clinic, 'Pius Brinzeu' County Emergency Clinical Hospital, Liviu Rebreanu 156, 300723 Timisoara, Romania. FAU - Bugi, Meda-Ada AU - Bugi MA AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. AD - Department of Pharmacy, University of Medicine and Pharmacy 'Vasile Goldis', 310025 Arad, Romania. FAU - Foghis, Cornel Flavius AU - Foghis CF AUID- ORCID: 0009-0009-4621-274X AD - Department XI of Pediatrics, First Pediatric University Clinic, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. AD - Ph.D. School Department, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. FAU - Isac, Raluca AU - Isac R AUID- ORCID: 0000-0003-1478-9797 AD - 4th Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. AD - Department XI of Pediatrics, Third Pediatric University Clinic, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. FAU - Marginean, Otilia AU - Marginean O AUID- ORCID: 0000-0003-2313-7643 AD - Department XI of Pediatrics, First Pediatric University Clinic, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. FAU - Balica, Nicolae Constantin AU - Balica NC AUID- ORCID: 0000-0001-7755-4608 AD - Department IX, Otolaryngology University Clinic, OftalmoSensory-Tumor Research Center-ORL (EYE-ENT), 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania. AD - Otorhinolaryngology Clinic, Emergency City Hospital, 300054 Timisoara, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260913 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 SB - IM MH - Humans MH - *Puberty, Precocious/metabolism/pathology/etiology MH - *Oxidative Stress MH - Animals MH - *Inflammation/metabolism/complications MH - *Hypothalamus/metabolism/pathology MH - *Obesity/metabolism/complications MH - Hypothalamic-Pituitary-Gonadal Axis MH - Female PMC - PMC13607323 OTO - NOTNLM OT - KNDy neurons OT - hypothalamus OT - neuroinflammation OT - obesity OT - oxidative stress OT - precocious puberty COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/13 CRDT- 2026/09/26 01:08 PHST- 2026/07/22 00:00 [received] PHST- 2026/09/08 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:08 [entrez] PHST- 2026/09/13 00:00 [pmc-release] AID - ijms27188159 [pii] AID - ijms-27-08159 [pii] AID - 10.3390/ijms27188159 [doi] PST - epublish SO - Int J Mol Sci. 2026 Sep 13;27(18):8159. doi: 10.3390/ijms27188159. PMID- 42794468 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 18 DP - 2026 Sep 9 TI - Targeted 3.34-Million CpG Site Sequencing Reveals Preliminary Cord Blood Epigenetic Alterations of Autism Spectrum Disorder: A Pilot Study Highlighting the PCDHA1-PCDHA8 Cluster. LID - 10.3390/ijms27188038 [doi] LID - 8038 AB - Rising reported Autism Spectrum Disorder (ASD) prevalence underscores the need to explore early perinatal biological markers. To conduct an exploratory pilot investigation of cord blood DNA methylation patterns as potential early epigenetic candidate loci associated with ASD in infants born to mothers with obesity and gestational diabetes. This prospective pilot study analyzed 14 mother-infant pairs comprising infants born to mothers with obesity and gestational diabetes later diagnosed with ASD (n = 2); healthy infants born to mothers with obesity and diabetes (IODM, n = 6); and healthy controls (IHM, n = 6). Targeted methyl-capture sequencing (covering 3.34 million CpG sites) identified differentially methylated region (DMR)-associated genes. Neurodevelopment was evaluated at 24-26 months using Bayley-III scales. ASD infants showed lower Bayley-III scores across all domains. In this small cohort (n = 2 ASD cases), we identified 249 DMR-associated genes common to both ASD vs. IHM and ASD vs. IODM comparisons, representing preliminary candidate loci. Enrichment analysis identified homophilic cell-cell adhesion as the most significant pathway (fold enrichment = 8.28; FDR = 6.31 x 10(-6)), driven by the PCDH1-PCDHA8 cluster, alongside morphogenesis in neuron differentiation (fold enrichment = 3.45; FDR = 2.08 x 10(-2)). Although prospective validation in larger independent cohorts is required, these pilot results suggest that cord blood PCDHA1-PCDHA8 cluster methylation alterations represent preliminary candidate loci for hypothesis generation and future biomarker evaluation, regardless of maternal metabolic status. FAU - Armas-Gonzalez, Marina AU - Armas-Gonzalez M AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Maranon, 28007 Madrid, Spain. FAU - Gonzalez-Gonzalez, Nieves Luisa AU - Gonzalez-Gonzalez NL AUID- ORCID: 0000-0003-1401-5580 AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. FAU - Gonzalez-Davila, Enrique AU - Gonzalez-Davila E AUID- ORCID: 0000-0002-0781-9161 AD - Mathematics, Statistics and Operations Research Department (IMAULL), University of La Laguna (ULL), 38320 La Laguna, Spain. FAU - Orribo-Morales, Olivia AU - Orribo-Morales O AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Department of Obstetrics and Gynecology, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Castro-Conde, Jose Ramon AU - Castro-Conde JR AUID- ORCID: 0000-0003-0867-2920 AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Pediatrics Department, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Gonzalez-Campos, Candelaria AU - Gonzalez-Campos C AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Pediatrics Department, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Flores, Carlos AU - Flores C AUID- ORCID: 0000-0001-5352-069X AD - Research Unit, Hospital Universitario Ntra. Sra. de Candelaria, Instituto de Investigacion Sanitaria de Canarias (IISC), 38010 Santa Cruz de Tenerife, Spain. AD - CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Lorenzo-Salazar, Jose Miguel AU - Lorenzo-Salazar JM AUID- ORCID: 0000-0002-5135-2861 AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Gonzalez-Montelongo, Rafaela AU - Gonzalez-Montelongo R AUID- ORCID: 0000-0001-9022-8663 AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Munoz-Barrera, Adrian AU - Munoz-Barrera A AUID- ORCID: 0000-0002-1561-5898 AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Padron-Perez, Erika AU - Padron-Perez E AUID- ORCID: 0000-0001-5243-3244 AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Department of Obstetrics and Gynecology, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Tascon-Padron, Laura AU - Tascon-Padron L AUID- ORCID: 0000-0001-9941-9001 AD - Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany. FAU - Nunez Catalan, Maria AU - Nunez Catalan M AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. LA - eng GR - PI18/01700/Instituto de Salud Carlos III/ PT - Journal Article DEP - 20260909 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Cadherins) SB - IM MH - Humans MH - *Fetal Blood/metabolism MH - Female MH - Pilot Projects MH - *DNA Methylation MH - *Epigenesis, Genetic MH - *CpG Islands/genetics MH - *Autism Spectrum Disorder/genetics MH - Pregnancy MH - *Cadherins/genetics MH - Male MH - Diabetes, Gestational/genetics MH - Prospective Studies MH - Adult MH - Case-Control Studies MH - Infant PMC - PMC13607789 OTO - NOTNLM OT - DNA OT - autism OT - cord blood OT - diabetes OT - enrichment analysis OT - epigenetic OT - maternal obesity OT - neurodevelopment OT - pregnancy OT - protocadherins COIS- The authors declare no conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/09 CRDT- 2026/09/26 01:07 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:07 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - ijms27188038 [pii] AID - ijms-27-08038 [pii] AID - 10.3390/ijms27188038 [doi] PST - epublish SO - Int J Mol Sci. 2026 Sep 9;27(18):8038. doi: 10.3390/ijms27188038. PMID- 42794299 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 9 DP - 2026 Sep 21 TI - Liking of Physical Education and Active Recess Among Chilean Schoolchildren: A National Population-Based Study of Participation Gaps and Reasons for Inactivity. LID - 10.3390/children13091279 [doi] LID - 1279 AB - Background/Objectives: Recess and physical education are complementary school-based opportunities for movement, yet national evidence on how students' liking of physical education relates to active recess is scarce in Latin America. We examined the association between disliking physical education and inactive recess among Chilean students and described reported reasons for inactive recess. Methods: This cross-sectional study used the 2024 Chilean National Survey of Physical Activity and Sports Habits. The primary analysis included 3802 school-attending participants aged 5-17 years with valid responses to the liking of physical education and recess activity items. Inactive recess was defined as reporting no running/jumping, sport, or dance during recess. Modified Poisson regression with normalized survey weights and robust variance estimated adjusted prevalence ratios (aPRs), controlling for age, sex assigned at birth, urban/rural area, socioeconomic status, disability, and region. Region-stratified bootstrap inference used 2000 replicates. Results: Weighted active-recess prevalence was 75.8%. Adjusted inactive-recess prevalence was 18.2% (95% confidence interval [CI] 16.0-20.4) among students who liked physical education and 56.9% (95% CI 50.3-63.6) among those who disliked it, an absolute difference of 38.7 percentage points (95% CI 31.6-45.8). Disliking physical education was associated with a prevalence of inactive recess approximately three times higher (aPR 3.09, 95% CI 2.61-3.68); the bootstrap CI was 2.61-3.69. Associations did not differ by sex or age group. Among 977 students with inactive recess, the most frequent reasons were lack of interest (40.3%) and absence of games, equipment, or a suitable place (29.1%). Conclusions: Disliking physical education was strongly associated with inactive recess, but temporality cannot be established. Enjoyable, inclusive physical education and better recess opportunities merit joint evaluation in school-based physical activity strategies. FAU - de Souza-Lima, Josivaldo AU - de Souza-Lima J AUID- ORCID: 0000-0003-4372-0836 AD - Facultad de Educacion y Humanidades, Escuela de Ciencias del Deporte, Universidad Andres Bello, Las Condes, Santiago 7550000, Chile. AD - Departamento de Didactica de la Expresion Musical, Plastica y Corporal, Facultad de Ciencias de la Educacion, Universidad de Granada, 18071 Granada, Spain. FAU - Giakoni-Ramirez, Frano AU - Giakoni-Ramirez F AUID- ORCID: 0000-0002-2685-8991 AD - Facultad de Educacion y Humanidades, Escuela de Ciencias del Deporte, Universidad Andres Bello, Las Condes, Santiago 7550000, Chile. FAU - Munoz-Strale, Catalina AU - Munoz-Strale C AUID- ORCID: 0009-0002-5354-1313 AD - Facultad de Educacion y Humanidades, Escuela de Ciencias del Deporte, Universidad Andres Bello, Las Condes, Santiago 7550000, Chile. FAU - Alarcon-Aguilar, Javiera AU - Alarcon-Aguilar J AUID- ORCID: 0000-0003-4267-046X AD - Facultad de Educacion y Humanidades, Escuela de Ciencias del Deporte, Universidad Andres Bello, Las Condes, Santiago 7550000, Chile. FAU - Farias-Valenzuela, Claudio AU - Farias-Valenzuela C AUID- ORCID: 0000-0002-4027-4415 AD - Escuela de Ciencias de la Actividad Fisica, el Deporte y la Salud, Universidad de Santiago de Chile (USACH), Santiago 9170124, Chile. FAU - Parra-Saldias, Maribel AU - Parra-Saldias M AUID- ORCID: 0000-0001-5488-9878 AD - Departamento de Educacion Fisica, Deporte y Recreacion, Universidad de Atacama, Copiapo 1530000, Chile. FAU - Duclos-Bastias, Daniel AU - Duclos-Bastias D AUID- ORCID: 0000-0002-9020-5776 AD - iGEO Research, Escuela de Educacion Fisica, Pontificia Universidad Catolica de Valparaiso, Valparaiso 2340021, Chile. AD - METIS Research Group, Facultad de Negocios y Tecnologia, Universidad Alfonso X el Sabio (UAX), 28691 Madrid, Spain. FAU - Godoy-Cumillaf, Andres AU - Godoy-Cumillaf A AUID- ORCID: 0000-0001-8613-6838 AD - Grupo de Investigacion en Educacion Fisica, Salud y Calidad de Vida (EFISAL), Facultad de Educacion, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Merellano-Navarro, Eugenio AU - Merellano-Navarro E AUID- ORCID: 0000-0002-1557-2285 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Reyes-Amigo, Tomas AU - Reyes-Amigo T AUID- ORCID: 0000-0001-6510-1230 AD - Physical Activity Sciences Observatory (OCAF), Universidad de Playa Ancha, Valparaiso 2340000, Chile. LA - eng PT - Journal Article DEP - 20260921 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13605189 OTO - NOTNLM OT - Chile OT - adolescents OT - children OT - liking of physical education OT - physical education OT - recess OT - school health COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/21 CRDT- 2026/09/26 01:07 PHST- 2026/08/04 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:07 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - children13091279 [pii] AID - children-13-01279 [pii] AID - 10.3390/children13091279 [doi] PST - epublish SO - Children (Basel). 2026 Sep 21;13(9):1279. doi: 10.3390/children13091279. PMID- 42794262 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 9 DP - 2026 Sep 14 TI - Biomarkers of Treatment-Escalation Risk by Obesity Status in Pediatric Asthma: A Development and External Validation Cohort Study. LID - 10.3390/children13091242 [doi] LID - 1242 AB - Background/Objectives: Obesity may alter the prognostic value of biomarkers in childhood asthma. We examined whether transforming growth factor beta 1 (TGF-beta1), soluble suppression of tumorigenicity 2 (sST2), C-X-C motif chemokine ligand 8 (CXCL8), and insulin-like growth factor 1 (IGF-1) were associated with sustained treatment escalation and whether associations differed by obesity status. Methods: The development cohort included 292 children: 90 non-atopic controls, 108 with normal-weight asthma, and 94 with obese asthma; longitudinal analyses included 202 with asthma. Biomarkers were modeled continuously in prespecified Cox models with biomarker-by-obesity interactions, internally validated with 1000 bootstrap resamples, and applied without refitting or recalibration to an independent Van cohort of 180 children with asthma. Results: Seventy-five children experienced sustained treatment escalation. TGF-beta1 was associated with escalation in obese asthma (hazard ratio [HR] per 500 pg/mL, 2.12; 95% confidence interval [CI], 1.66-2.70; interaction q < 0.001), whereas CXCL8 was associated with escalation in normal-weight asthma (HR per 10 pg/mL, 2.06; 95% CI, 1.67-2.54; interaction q < 0.001). Adding TGF-beta1 or CXCL8 increased 12-month time-dependent area under the curve (AUC) from 0.623 to 0.732 and 0.746. In Van, AUCs were 0.751 and 0.744, and interactions remained significant after adjustment (q = 0.036). sST2 showed a weaker obesity-related signal, whereas IGF-1 added little prognostic information. Conclusions: Prognostic biomarker associations differed by obesity status. TGF-beta1 was associated with escalation in obese asthma, whereas CXCL8 was associated with escalation in normal-weight asthma. Further validation is needed before clinical use. FAU - Goktas, Serdar AU - Goktas S AUID- ORCID: 0000-0002-5738-4979 AD - Department of Pediatrics, Clinic of Pediatric Immunology and Allergy, Mersin City Training and Research Hospital, 33240 Mersin, Turkiye. AD - Department of Pediatrics, Clinic of Pediatric Immunology and Allergy, Van Training and Research Hospital, 65300 Van, Turkiye. FAU - Kaya, Mehmet Sirin AU - Kaya MS AUID- ORCID: 0000-0001-9416-9058 AD - Department of Pediatrics, Clinic of Pediatric Immunology and Allergy, Sanliurfa Training and Research Hospital, 63200 Sanliurfa, Turkiye. LA - eng PT - Journal Article DEP - 20260914 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13605966 OTO - NOTNLM OT - CXCL8 OT - TGF-beta1 OT - childhood obesity OT - external validation OT - pediatric asthma OT - prognostic model OT - treatment escalation COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/14 CRDT- 2026/09/26 01:07 PHST- 2026/08/09 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:07 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - children13091242 [pii] AID - children-13-01242 [pii] AID - 10.3390/children13091242 [doi] PST - epublish SO - Children (Basel). 2026 Sep 14;13(9):1242. doi: 10.3390/children13091242. PMID- 42794233 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 9 DP - 2026 Sep 8 TI - Risk Factors Influencing Neurodevelopmental Outcome and Survival in Preterm Infants: A Prospective Cohort Study. LID - 10.3390/children13091214 [doi] LID - 1214 AB - BACKGROUND/OBJECTIVES: Survival of infants born very preterm or with very low birth weight has improved without a comparable reduction in neurodevelopmental morbidity, and the exposures acting during neonatal intensive care are usually studied in isolation. We aimed to identify which prenatal, perinatal and postnatal factors are independently associated, domain by domain, with neurodevelopment at 24 months' corrected age (CA) and with the composite outcome of neurodevelopment and survival. METHODS: Single-centre prospective cohort of 146 infants (135 assessed at 24 months' CA and 11 who died between day 8 of life and the assessment) with gestational age /= 0.50, without direct assessment of biochemical or hemodynamic parameters. Receiver operating characteristic (ROC) curves, optimal Youden-derived cut-offs, and internal bootstrap validation (1000 resamples) were performed. RESULTS: Anthropometric parameters demonstrated high discriminatory performance for detecting WHtR-defined surrogate risk across all sex and maturation cohorts (AUC = 0.88-0.98). Unadjusted physical fitness tests showed poor overall classification performance. However, normalizing fitness metrics for body mass (particularly relative CMJ and cardiorespiratory fitness) substantially improved discriminatory capacity. Optimal cut-off values for anthropometric indicators displayed an observed descending pattern across progressively later-maturing cohorts. CONCLUSIONS: Anthropometric parameters represent highly accurate field proxies for WHtR-defined surrogate risk screening in adolescents. While unadjusted fitness metrics have limited utility for this anthropometric outcome, body-mass-normalized fitness parameters substantially recover classification capacity. Biological maturation timing should be carefully considered when future research derives and externally validates adolescent screening thresholds, as current cut-offs remain exploratory and sample-derived. FAU - Lopez-Lombo, Victoria AU - Lopez-Lombo V AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. FAU - Mateo-Orcajada, Adrian AU - Mateo-Orcajada A AUID- ORCID: 0000-0001-8111-8358 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. FAU - Abenza-Cano, Lucia AU - Abenza-Cano L AUID- ORCID: 0000-0001-9583-737X AD - Facultad de Deporte, UCAM Universidad Catolica San Antonio de Murcia, 30107 Guadalupe, Murcia, Spain. FAU - Abraldes, J Arturo AU - Abraldes JA AUID- ORCID: 0000-0003-4527-3865 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. FAU - Albaladejo-Saura, Mario AU - Albaladejo-Saura M AUID- ORCID: 0000-0003-0234-7756 AD - Facultad de Deporte, UCAM Universidad Catolica San Antonio de Murcia, 30107 Guadalupe, Murcia, Spain. FAU - Vaquero-Cristobal, Raquel AU - Vaquero-Cristobal R AUID- ORCID: 0000-0003-2708-4817 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. LA - eng GR - PID2022-140245OA-I00/Ministerio de Ciencia e Innovacion/ PT - Journal Article DEP - 20260905 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13605130 OTO - NOTNLM OT - ROC curves OT - WHtR-defined cardiometabolic risk OT - Youden index OT - adolescents OT - body composition OT - maturity status OT - physical fitness OT - sex COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/05 CRDT- 2026/09/26 01:07 PHST- 2026/08/09 00:00 [received] PHST- 2026/09/01 00:00 [revised] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:07 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - children13091201 [pii] AID - children-13-01201 [pii] AID - 10.3390/children13091201 [doi] PST - epublish SO - Children (Basel). 2026 Sep 5;13(9):1201. doi: 10.3390/children13091201. PMID- 42794220 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 9 DP - 2026 Sep 5 TI - Updated Age- and Sex-Specific Reference Values and Anthropometric Correlates of Maximum Handgrip Strength in Preschool Children from the Araucania Region, Chile. LID - 10.3390/children13091200 [doi] LID - 1200 AB - Background/Objectives: Handgrip strength is a simple and reliable indicator of muscular fitness during childhood. However, updated reference values for handgrip strength in preschool children remain limited in many countries, including Chile. This study aimed to develop updated age- and sex-specific reference values for maximum handgrip strength in preschool children aged 4-6 years from the Araucania Region, Chile, and to examine its associations with age and anthropometric characteristics. Methods: This cross-sectional study included 899 preschool children (464 boys and 435 girls) from the Araucania Region, Chile. Handgrip strength was assessed using a Takei 5401 digital dynamometer following the PREFIT protocol. Maximum handgrip strength was defined as the highest value obtained from either hand. Age- and sex-specific percentile reference values (P5, P10, P25, P50, P75, P90, and P95) and interpolated percentile curves were generated. Associations of maximum handgrip strength with age and anthropometric variables were examined using Spearman's rank correlation coefficients. Results: Maximum handgrip strength increased progressively from 4 to 6 years in both sexes, with boys showing significantly higher mean values than girls at each age (all p /=70 years hospitalised in geriatric wards, by assessing visual and lexical recognition of pre-selected food items. Step 2 will evaluate the test-retest reliability and practical feasibility of administering the preference questionnaire in a new cohort of older adults. Step 3 will be a cross-sectional study describing food preferences and comparing Preference Indexes between participants screening positive and screening negative for dysphagia using the Eating Assessment Tool-10. The questionnaire will include six categories of food (acidic, textured, sweet, in sauce, dairy and cooked). A total of 209 participants will be included across acute geriatric, rehabilitation and long-term care units (35 participants in step 1, 35 participants in step 2 and 174 participants in step 3, with the 35 participants from step 2 included in the step 3 population). Descriptive and comparative analyses will be performed according to a predefined statistical analysis plan. ETHICS AND DISSEMINATION: The study protocol was approved by the Comite de Protection des Personnes (CPP) Ile-de-France III on 11 September 2025 (approval number: 25.02467.000911-2025-A00795-44), in accordance with French legislation. All participants will provide informed non-opposition in accordance with national regulations. The results of the primary and secondary objectives will be disseminated through peer-reviewed publications, conference presentations and communication with clinical stakeholders. TRIAL REGISTRATION NUMBER: NCT05734586. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Masse-Deragon, Nicolas AU - Masse-Deragon N AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France nicolas.masse-deragon@chu-lyon.fr. FAU - Tripoz-Dit-Masson, Stephanie AU - Tripoz-Dit-Masson S AD - CRC Vieillissement Cerveau Fragilite, Hospices Civils de Lyon, Lyon, France. FAU - Grehalle, Coline AU - Grehalle C AD - Speech therapist team - Centre Hospitalier de Pierre Garraud, Hospices Civils de Lyon, Lyon, France. FAU - Subtil, Fabien AU - Subtil F AD - Service de Biostatistique, Hospices Civils de Lyon, Lyon, Auvergne-Rhone-Alpes, France. AD - CNRS, UMR5558, Laboratoire de Biometrie et Biologie Evolutive, Universite Claude Bernard Lyon 1, Villeurbanne, France. FAU - Rouze, Heloise AU - Rouze H AD - Pole de Sante Publique, Hospices Civils de Lyon, Lyon, France. AD - Laboratoire Reshape, Universite Claude Bernard Lyon 1, Lyon, France. FAU - Grilot, Cecile AU - Grilot C AD - Dietitian team - Centre Hospitalier Pierre Garraud, Hospices Civils de Lyon, Lyon, France. FAU - Merazga, Salima AU - Merazga S AD - Direction a la Recherche en Sante, Hospices Civils de Lyon, Lyon, France. FAU - Goldet, Karine AU - Goldet K AD - Centre de Recherche Clinique Vieillissement Cerveau Fragilite - Hopital des Charpennes, Hospices Civils de Lyon, Villeurbanne, France. FAU - Durlach, Olivier AU - Durlach O AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. FAU - Schir, Sophie AU - Schir S AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. AD - Geriatric department - Centre Hospitalier Pierre Garraud, Hospices Civils de Lyon, Lyon, France. FAU - Haution-Bitker, Marine AU - Haution-Bitker M AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. AD - Geriatric department - Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France. FAU - Merdinian, Marion AU - Merdinian M AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. AD - Geriatric department - Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France. FAU - Falandry, Claire AU - Falandry C AUID- ORCID: 0000-0001-7267-4723 AD - CarMeN Laboratory, Inserm U1060, INRA U1397, Universite Claude Bernard Lyon 1, INSA Lyon, Charles Merieux Medical School, University of Lyon, Oullins, France. AD - Geriatric department - Centre Hospitalier de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France. LA - eng SI - ClinicalTrials.gov/NCT05734586 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260925 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Deglutition Disorders/diagnosis/psychology MH - *Food Preferences MH - Frail Elderly MH - *Geriatric Assessment/methods MH - Prospective Studies MH - Reproducibility of Results MH - Research Design MH - Surveys and Questionnaires MH - Multicenter Studies as Topic PMC - PMC13630011 OTO - NOTNLM OT - Frail Elderly OT - GERIATRIC MEDICINE OT - NUTRITION & DIETETICS OT - Organisation of health services OT - Protocols & guidelines COIS- Competing interests: NM-D reports financial support was provided by La Societe Francophone de Nutrition Clinique et Metabolisme. CF reports a relationship with Geriamed that includes: speaking and lecture fees. EDAT- 2026/09/25 23:47 MHDA- 2026/09/25 23:48 PMCR- 2026/09/25 CRDT- 2026/09/25 20:43 PHST- 2026/09/25 23:48 [medline] PHST- 2026/09/25 23:47 [pubmed] PHST- 2026/09/25 20:43 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - bmjopen-2026-120395 [pii] AID - 10.1136/bmjopen-2026-120395 [doi] PST - epublish SO - BMJ Open. 2026 Sep 25;16(9):e120395. doi: 10.1136/bmjopen-2026-120395. PMID- 42789770 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261009 IS - 2368-7959 (Electronic) IS - 2368-7959 (Linking) VI - 13 DP - 2026 Sep 25 TI - Perinatal Mental Health Detection and Prediction Using Mobile Sensing Data: Systematic Review. PG - e101677 LID - 10.2196/101677 [doi] LID - e101677 AB - BACKGROUND: Perinatal mental health disorders affect approximately 20% of pregnant and postpartum individuals, and are associated with substantial maternal and infant morbidity. Traditional assessment relies on infrequent, subjective self-reports. Mobile devices, including smartphones and wearables, offer opportunities for continuous and objective measurement, but evidence on their assessment utility in perinatal populations remains fragmented. OBJECTIVE: This review aimed to examine the application of wearable devices and smartphones for detecting and predicting perinatal mental health outcomes, with emphasis on predictive performance, informative features, and methodological rigor. METHODS: We conducted a systematic review following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (PROSPERO CRD420251249218). Six databases (PubMed, Web of Science, Scopus, PsycINFO, IEEE Xplore, and ACM Digital Library) were searched initially in January 2026 and supplemented by an amended search in June 2026, with no publication date restrictions. Evidence was synthesized narratively, and the risk of bias was assessed using PROBAST+AI (Prediction Model Risk of Bias Assessment Tool With AI extension). RESULTS: The initial and supplementary searches yielded 1952 unique records after deduplication, of which 10 studies met the inclusion criteria. The included studies covered postpartum depression, prenatal stress, discrete emotions during pregnancy (eg, happiness, anxiety, and sadness), and maternal loneliness. High discrimination metrics were reported for postpartum depression in individual studies, including a multiclass area under the curve of 0.85, a binary area under the curve of 0.871, and an F(1)-score of 0.9872. Heart rate variability, GPS-derived mobility, physical activity, and sleep features were most frequently reported as useful, and their interpretation requires perinatal-specific contextualization. Methodological quality was limited, with 80% (12/15) of PROBAST+AI assessment units rated as having high overall quality concern or risk of bias, mainly due to small samples, limited validation, inadequate handling of missing data, and potential overfitting in the analysis domain. CONCLUSIONS: Mobile sensing shows preliminary potential for perinatal mental health assessment, but current evidence does not yet support clinical screening or decision-making, and independent external validation in perinatal populations is currently lacking. Progress toward clinical utility requires broader mental health outcome coverage, larger longitudinal cohorts, standardized analytical and reporting practices, adoption of modeling approaches better suited to perinatal trajectories, independent external validation, and human-centered monitoring designs. CI - (c) Yifan Sun, Kemeng Che, Tella Lantta, Anna Axelin, Iman Azimi, Pasi Liljeberg. Originally published in JMIR Mental Health (https://mental.jmir.org). FAU - Sun, Yifan AU - Sun Y AUID- ORCID: 0009-0009-1897-0308 AD - Department of Computing, University of Turku, Yliopistonmaki, Turku, Southwest Finland, FI-20014, Finland, 358 0449508020. FAU - Che, Kemeng AU - Che K AUID- ORCID: 0009-0002-3086-6166 AD - Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland. FAU - Lantta, Tella AU - Lantta T AUID- ORCID: 0000-0001-7715-7573 AD - Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland. FAU - Axelin, Anna AU - Axelin A AUID- ORCID: 0000-0003-2743-3589 AD - Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland. FAU - Azimi, Iman AU - Azimi I AUID- ORCID: 0000-0001-5003-299X AD - Department of Computing, University of Turku, Yliopistonmaki, Turku, Southwest Finland, FI-20014, Finland, 358 0449508020. FAU - Liljeberg, Pasi AU - Liljeberg P AUID- ORCID: 0000-0002-9392-3589 AD - Department of Computing, University of Turku, Yliopistonmaki, Turku, Southwest Finland, FI-20014, Finland, 358 0449508020. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260925 PL - Canada TA - JMIR Ment Health JT - JMIR mental health JID - 101658926 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Mental Disorders/diagnosis MH - *Pregnancy Complications/diagnosis MH - *Wearable Electronic Devices MH - Digital Health MH - *Smartphone PMC - PMC13614507 OTO - NOTNLM OT - digital phenotyping OT - machine learning OT - perinatal mental health OT - postpartum depression OT - smartphone sensing OT - systematic review OT - wearable devices COIS- Conflicts of Interest: None declared. EDAT- 2026/09/25 17:33 MHDA- 2026/09/25 17:34 PMCR- 2026/09/25 CRDT- 2026/09/25 14:53 PHST- 2026/05/18 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/25 17:34 [medline] PHST- 2026/09/25 17:33 [pubmed] PHST- 2026/09/25 14:53 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - v13i1e101677 [pii] AID - 101677 [pii] AID - 10.2196/101677 [doi] PST - epublish SO - JMIR Ment Health. 2026 Sep 25;13:e101677. doi: 10.2196/101677. PMID- 42789372 OWN - NLM STAT- Publisher LR - 20260925 IS - 1746-1553 (Electronic) IS - 0309-3646 (Linking) DP - 2026 Aug 10 TI - Machine learning-based prediction model for initial correction effect of Cheneau brace in adolescent idiopathic scoliosis. LID - 10.1097/PXR.0000000000000582 [doi] AB - BACKGROUND: Predicting the initial correction rate (ICR) of Cheneau brace treatment for adolescent idiopathic scoliosis (AIS) is critical for personalized therapeutic planning but remains underexplored. This study aims to develop a clinical prediction model for ICR evaluation. METHODS: A retrospective analysis included 391 spinal curves from 310 patients with AIS (since some patients have double curves) from 4 orthotic centers. Key variables encompassed demographics, axial trunk rotation (ATR), Risser sign, curve type (C-shaped/S-shaped), apical location (thoracic/lumbar), and prebrace Cobb angle. ICR was calculated as [(prebrace Cobb - postbrace Cobb)/prebrace Cobb] x 100%, with satisfactory correction defined as ICR >/=50%. Logistic regression and random forest models were trained (70% data) and validated (30%). Feature importance was assessed through mean decrease accuracy (MDA) and Gini (MDG). A nomogram integrated significant predictors. RESULTS: Multivariate analysis identified Risser sign (OR = 0.033, P < 0.001), ATR (OR = 0.853, P < 0.001), curve type (OR = 0.485, P = 0.036), apical location (OR = 5.827, P < 0.001), and BMI (OR = 0.897, P = 0.041) as independent predictors. Random forest confirmed Risser sign as the most influential variable (MDA = 28.07%, MDG = 24.35%), followed by ATR (MDA = 21.99%, MDG = 19.50%). Both models demonstrated high predictive accuracy: logistic regression (AUC = 0.951, accuracy = 0.879) and random forest (AUC = 0.959, accuracy = 0.897). Lumbar curves and C-shaped curves exhibited superior correctability. CONCLUSION: Machine learning models effectively predict Cheneau brace ICR, with Risser sign and ATR angle as primary determinants. The developed nomogram provides a practical tool for pretreatment outcome anticipation, enhancing clinical decision-making in AIS management. CI - Copyright (c) 2026 The Authors. Published by Wolters Kluwer incorporated on behalf of The International Society for Prosthetics and Orthotics. FAU - Li, Kai-Hua AU - Li KH AUID- ORCID: 0000-0001-7543-2324 AD - Institute of Orthopedics, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. AD - North China University of Science and Technology, Tangshan, Hebei, China. FAU - Zhang, Li-Ning AU - Zhang LN AD - Department of Medical Radiology, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. FAU - Xiong, Hui-Ling AU - Xiong HL AD - Department of Medical Radiology, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. FAU - Chen, Bao-Sheng AU - Chen BS AD - Institute of Orthopedics, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. FAU - Yi, Li-Sha AU - Yi LS AD - Institute of Nursing, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. LA - eng GR - 23422083389/Handan Science and Technology Research and Development Program Project/ PT - Journal Article DEP - 20260810 PL - France TA - Prosthet Orthot Int JT - Prosthetics and orthotics international JID - 7707720 SB - IM OTO - NOTNLM OT - Cheneau brace OT - adolescent idiopathic scoliosis OT - initial correction rate OT - machine learning OT - predictive modeling OT - risser sign EDAT- 2026/09/25 17:33 MHDA- 2026/09/25 17:33 CRDT- 2026/09/25 12:33 PHST- 2025/11/23 00:00 [received] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/09/25 17:33 [medline] PHST- 2026/09/25 17:33 [pubmed] PHST- 2026/09/25 12:33 [entrez] AID - 00006479-990000000-00460 [pii] AID - 10.1097/PXR.0000000000000582 [doi] PST - aheadofprint SO - Prosthet Orthot Int. 2026 Aug 10. doi: 10.1097/PXR.0000000000000582. PMID- 42788574 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1984-0462 (Electronic) IS - 0103-0582 (Print) IS - 0103-0582 (Linking) VI - 44 DP - 2026 TI - Factors associated with musculoskeletal pain in the spinal column of children and adolescents: a cross-sectional study with network analysis. PG - e2026040 LID - S0103-05822026000101028 [pii] LID - 10.1590/1984-0462/2026/44/2026040 [doi] LID - e2026040 AB - OBJECTIVE: The aim of this study was to analyze the relationship between musculoskeletal spinal pain and individual, behavioral, and contextual factors in children and adolescents. METHODS: A cross-sectional study was conducted with 189 children and adolescents (10-16 years), of both genders, enrolled in public and private schools in Belem, Para, Brazil. Musculoskeletal pain and postural habits were assessed using the Back Pain and Posture Evaluation Instrument for Children and Adolescents, a validated questionnaire for this population. Network analysis using the EBICglasso estimator explored associations between individual (age, gender), behavioral (physical activity in school and leisure contexts), and contextual factors (school type and postural habits related to daily activities and electronic device use) and the presence of neck and low back pain. RESULTS: The prevalence of low back pain was 62.6% and neck pain 65.4%. Low back pain was negatively associated with family history of pain (r=-0.14) and positively associated with female gender (r=0.19) and neck pain (r=0.12). Sitting posture during electronic device use was negatively associated with neck pain (r=-0.19). Gender and age showed higher centrality, indicating greater influence within the network, while physical activity showed a negative influence on pain outcomes. CONCLUSIONS: Musculoskeletal spinal pain was highly prevalent and associated with multiple interrelated factors. Network analysis highlights its multifactorial nature and provides relevant insights into key variables that may guide integrated health promotion and early prevention strategies in pediatric populations. FAU - Gomes, Marcella Veronnica Pereira AU - Gomes MVP AUID- ORCID: 0000-0002-2137-9246 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Belem, Ruth Stefany Monteiro AU - Belem RSM AUID- ORCID: 0009-0004-6056-7364 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Pantoja, Amanda Vitoria Gomes AU - Pantoja AVG AUID- ORCID: 0009-0009-4507-7670 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Costa, Beatriz Dos Santos AU - Costa BDS AUID- ORCID: 0000-0002-5110-4884 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Jardim, Naina Yuki Vieira AU - Jardim NYV AUID- ORCID: 0000-0003-3760-3684 AD - Universidade Estadual do Para, Tucurui, PA, Brazil. FAU - Crisp, Alex Harley AU - Crisp AH AUID- ORCID: 0000-0003-4683-9576 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Magalhaes, Mauricio Oliveira AU - Magalhaes MO AUID- ORCID: 0000-0002-7857-021X AD - Universidade Federal do Para, Belem, PA, Brazil. LA - eng PT - Journal Article DEP - 20260918 PL - Brazil TA - Rev Paul Pediatr JT - Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo JID - 9109353 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Child MH - Male MH - Adolescent MH - *Musculoskeletal Pain/epidemiology/etiology MH - Prevalence MH - Brazil/epidemiology MH - *Neck Pain/epidemiology/etiology MH - Risk Factors MH - Posture MH - *Low Back Pain/epidemiology/etiology PMC - PMC13588557 EDAT- 2026/09/25 11:45 MHDA- 2026/09/25 11:46 PMCR- 2026/09/18 CRDT- 2026/09/25 10:34 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/09/25 11:46 [medline] PHST- 2026/09/25 11:45 [pubmed] PHST- 2026/09/25 10:34 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - S0103-05822026000101028 [pii] AID - 10.1590/1984-0462/2026/44/2026040 [doi] PST - epublish SO - Rev Paul Pediatr. 2026 Sep 18;44:e2026040. doi: 10.1590/1984-0462/2026/44/2026040. eCollection 2026. PMID- 42788340 OWN - NLM STAT- Publisher LR - 20261006 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Sep 25 TI - Urine diagnostics in paediatric intestinal failure: A prospective cohort study of alternative sampling methods. LID - 10.1002/jpn3.70597 [doi] AB - OBJECTIVES: Regular monitoring of urinary electrolyte excretion and kidney function is essential in children with intestinal failure (IF) receiving long-term parenteral nutrition (PN). This study evaluated alternative urine sampling methods against 24-h urine collection (UC) and assessed the prevalence of chronic kidney disease (CKD) and renal abnormalities. METHODS: In this prospective single-centre cohort study, 31 paediatric IF patients underwent 24-h UC, spot urine (SU) sampling, and shorter timed collections at predefined intervals. Urinary electrolytes and derived ratios were analysed. Kidney function was evaluated using cystatin C (CysC)- and creatinine (Cr)-based estimated glomerular filtration rate (eGFR) and 24-h urinary Cr clearance (CrCl). Agreement between alternative sampling methods and 24-h UC was assessed using Bland-Altman and regression analyses. Renal abnormalities were evaluated by ultrasound. RESULTS: Shorter timed UCs, particularly those corresponding to the PN infusion interval, showed the closest agreement with 24-h UC for sodium, magnesium, calcium, and phosphate excretion. Certain SU samples detected electrolyte deficiencies, particularly sodium and magnesium depletion, and low sodium-to-potassium ratios, highlighting cyclic dehydration at the end of the PN-free interval. CKD was detected in 15/30 patients (50%) by creatinine-cysC-based eGFR. Proteinuria was present in 17/29 patients (58.6%) in 24-h UC, and albuminuria in 13/26 SU samples (50%). Nephrocalcinosis was found in 37% of patients. CONCLUSIONS: Shorter timed UC and targeted SU samples may provide practical alternatives to 24-h UC for monitoring urinary electrolyte status and hydration. CKD and renal abnormalities are prevalent in children with IF receiving PN. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Sakaeva, Anna AU - Sakaeva A AD - Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Busch, Andreas AU - Busch A AD - Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. AD - Paediatric Gastroenterology and Hepatology, Children's Hospital Princess Margaret Darmstadt, Darmstadt, Germany. FAU - Holle, Johannes AU - Holle J AUID- ORCID: 0000-0001-8032-4096 AD - Paediatric Nephrology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Bartolomaeus, Hendrik AU - Bartolomaeus H AUID- ORCID: 0000-0003-4288-3828 AD - Institute of Experimental Biomedicine, University Hospital Wurzburg, Wurzburg, Germany. FAU - Fode, Bernd AU - Fode B AD - Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Tsiflikas, Ilias AU - Tsiflikas I AUID- ORCID: 0000-0001-7166-4689 AD - Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Tubingen, Germany. FAU - Sturm, Ekkehard AU - Sturm E AUID- ORCID: 0000-0002-1489-8662 AD - Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Slavetinsky, Christoph AU - Slavetinsky C AUID- ORCID: 0000-0001-5576-5906 AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Scherer, Simon AU - Scherer S AUID- ORCID: 0000-0002-6404-6919 AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Fuchs, Jorg AU - Fuchs J AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Lieber, Justus AU - Lieber J AUID- ORCID: 0000-0003-1421-0984 AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Warmann, Steven W AU - Warmann SW AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. AD - Paediatric Surgery and Paediatric Urology, Charite University Hospital, Berlin, Germany. FAU - Hilberath, Johannes AU - Hilberath J AUID- ORCID: 0009-0005-0055-7452 AD - Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. LA - eng GR - None/ PT - Journal Article DEP - 20260925 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - albuminuria OT - nephrocalcinosis OT - parenteral nutrition OT - proteinuria EDAT- 2026/09/25 11:45 MHDA- 2026/09/25 11:45 CRDT- 2026/09/25 10:22 PHST- 2026/08/20 00:00 [revised] PHST- 2026/06/12 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/09/25 11:45 [pubmed] PHST- 2026/09/25 11:45 [medline] PHST- 2026/09/25 10:22 [entrez] AID - 10.1002/jpn3.70597 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Sep 25. doi: 10.1002/jpn3.70597. PMID- 42788139 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260925 LR - 20260926 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Plasma Homocysteine as a Biomarker for Cardiovascular Risk Stratification in Children and Adolescents With Type 1 Diabetes Mellitus: A Cross-Sectional Study From Western Algeria. PG - e115169 LID - 10.7759/cureus.115169 [doi] LID - e115169 AB - Background Cardiovascular disease (CVD) remains the leading cause of premature morbidity and mortality among individuals living with type 1 diabetes mellitus (T1DM). Although overt cardiovascular events are uncommon during childhood, endothelial dysfunction and subclinical atherosclerosis develop early, making timely cardiovascular risk assessment essential. Plasma homocysteine has emerged as a potential biomarker of vascular injury; however, its clinical value in pediatric T1DM remains controversial, and evidence from African populations is scarce. This study aimed to evaluate plasma homocysteine concentrations in children and adolescents with T1DM and to investigate their relationship with cardiovascular risk profiles and diabetes-related complications. Methods A cross-sectional observational study was conducted at the Department of Pediatrics B, in the university hospital center of Oran, Algeria. A total of 50 children and adolescents aged 5-19 years with confirmed T1DM were included. Demographic, anthropometric, clinical, and laboratory data were retrospectively collected from medical records. Plasma total homocysteine (tHcy) concentrations, glycemic control, lipid profile, diabetes duration, insulin therapy, nephropathy, and cardiovascular risk factors were analyzed. Hyperhomocysteinemia prevalence was determined, and its association with cardiovascular risk stratification was assessed using descriptive and inferential statistical analyses. Results The study included 27 male (54%) and 23 female patients (46%), and hyperhomocysteinemia was identified in 17 of 50 participants (34%). Plasma tHcy concentrations were significantly higher in participants with HbA1c >7.5% than in those with HbA1c 7.5%; aOR = 3.26, 95% CI: 1.18-9.02; p = 0.021) and diabetes duration >/=5 years (aOR = 2.54, 95% CI: 1.01-6.42; p = 0.047) were independently associated with hyperhomocysteinemia. Plasma tHcy showed good discriminative ability for the study-specific moderate-to-high cardiovascular risk classification (AUC = 0.82, 95% CI: 0.69-0.94; p < 0.001). Conclusion Hyperhomocysteinemia was prevalent among children and adolescents with T1DM in our cohort and was associated with an unfavorable cardiovascular risk-factor profile. These findings suggest that plasma homocysteine may represent a potential investigational adjunctive marker of cardiovascular risk-factor burden in pediatric T1DM. Prospective multicenter studies are warranted to validate these associations and determine their incremental clinical value beyond established cardiovascular risk factors. CI - Copyright (c) 2026, Ameur et al. FAU - Ameur, Auda AU - Ameur A AD - Department of Pediatrics B, Amilcar Cabral, University of Oran 1 Ahmed Ben Bella, Oran, DZA. FAU - Latroch, Charef AU - Latroch C AD - Department of Pediatrics B, Amilcar Cabral, University of Oran 1 Ahmed Ben Bella, Oran, DZA. FAU - Naas, Hiba AU - Naas H AD - Laboratory of Environment, Natural Plant Substances and Food Technology, Faculty of Natural and Life Sciences, Ahmed Zabana University - Relizane, Relizane, DZA. FAU - Amraoui, Fatima AU - Amraoui F AD - Faculty of Natural and Life Sciences, Ahmed Zabana University - Relizane, Relizane, DZA. FAU - Aribi, Nacera AU - Aribi N AD - Faculty of Natural and Life Sciences, Ahmed Zabana University - Relizane, Relizane, DZA. FAU - Bouziane Nedjadi, Karim AU - Bouziane Nedjadi K AD - Department of Pediatrics B, Amilcar Cabral, University of Oran 1 Ahmed Ben Bella, Oran, DZA. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13608191 OTO - NOTNLM OT - algeria OT - cardiovascular disease risk factors OT - homocysteine OT - pediatric type 1 diabetes OT - vascular endothelial dysfunction COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Ethics committee of faculty of medicine of Oran issued approval dd. This study was reviewed and approved by the Ethics Committee of the Faculty of Medicine, University of Oran, Algeria (Approval No. 0082/26; July 11, 2026). The study was conducted in accordance with the ethical principles of the Declaration of Helsinki and applicable institutional guidelines for research involving human participants. (ARABIC AND FRENCH ORIGINAL DOCUMENT). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/25 11:45 MHDA- 2026/09/25 11:46 PMCR- 2026/08/25 CRDT- 2026/09/25 10:03 PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/25 11:46 [medline] PHST- 2026/09/25 11:45 [pubmed] PHST- 2026/09/25 10:03 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.7759/cureus.115169 [doi] PST - epublish SO - Cureus. 2026 Aug 25;18(8):e115169. doi: 10.7759/cureus.115169. eCollection 2026 Aug. PMID- 42787313 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260925 LR - 20260926 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 13 DP - 2026 TI - Impact of anatomic complexity of congenital heart disease on growth retardation: a large retrospective cohort study. PG - 1907307 LID - 10.3389/fcvm.2026.1907307 [doi] LID - 1907307 AB - BACKGROUND: Growth retardation (GR) is a significant comorbidity in children with congenital heart disease (CHD), particularly those with complex CHD. This study aimed to characterize the growth patterns of pediatric CHD patients and to identify the factors associated with GR. METHODS: This retrospective cohort study included CHD patients aged /= 5 hospitalizations, comorbid substance use, and higher scores of emotional abuse were associated with a lower likelihood of response to lithium. DISCUSSION: Integrating the evaluation of trauma history, impulsive profiles, ruminative tendencies, and circadian features into clinical assessment may enhance the prediction of lithium response. CONCLUSION: Our findings support the development of personalized treatment strategies for BD. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Aguglia, Andrea AU - Aguglia A AUID- ORCID: 0000-0002-2003-2101 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. FAU - Breda, Giulia Silvia AU - Breda GS AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Aprile, Valentina AU - Aprile V AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Gagliardi, Michela AU - Gagliardi M AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Stefanini, Francesco AU - Stefanini F AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Conio, Benedetta AU - Conio B AUID- ORCID: 0000-0002-8201-7193 AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. FAU - Costanza, Alessandra AU - Costanza A AUID- ORCID: 0000-0001-6387-6462 AD - Department of Psychiatry, Faculty of Medicine, Geneva University (UNIGE), 1205 Geneva, Switzerland. AD - Department of Psychiatry, Faculty of Biomedical Sciences, University of Italian Switzerland (USI), 6900 Lugano, Switzerland. FAU - Amore, Mario AU - Amore M AUID- ORCID: 0000-0003-2927-2192 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Amerio, Andrea AU - Amerio A AUID- ORCID: 0000-0002-3439-340X AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. FAU - Serafini, Gianluca AU - Serafini G AUID- ORCID: 0000-0002-6631-856X AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. LA - eng PT - Journal Article DEP - 20260921 PL - United Arab Emirates TA - Curr Neuropharmacol JT - Current neuropharmacology JID - 101157239 SB - IM OTO - NOTNLM OT - Bipolar disorder OT - bipolar cycle OT - chronotype OT - lithium OT - rumination OT - trauma EDAT- 2026/09/25 05:31 MHDA- 2026/09/25 05:31 CRDT- 2026/09/25 02:56 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/19 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/09/25 05:31 [medline] PHST- 2026/09/25 05:31 [pubmed] PHST- 2026/09/25 02:56 [entrez] AID - CN-EPUB-158554 [pii] AID - 10.2174/011570159X482667260909062619 [doi] PST - aheadofprint SO - Curr Neuropharmacol. 2026 Sep 21. doi: 10.2174/011570159X482667260909062619. PMID- 42786460 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260926 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Sep 3 TI - Combined use of the pediatric Yorkhill malnutrition score and mid-upper arm circumference for identifying nutritional risk and predicting length of hospital stay in hospitalized children: a pilot study. LID - 10.1186/s12887-026-07609-5 [doi] LID - 905 AB - BACKGROUND: Childhood malnutrition remains a critical public health challenge among hospitalized pediatric populations, contributing to increased morbidity and prolonged length of hospital stay (LOS). In countries undergoing nutritional transition, such as Turkiye, the "double burden of malnutrition"-characterized by the coexistence of undernutrition and obesity-is exacerbated by socio-economic inequities. This study aimed to assess the prevalence and risk factors of malnutrition in hospitalized children and to evaluate the predictive validity of two rapid screening tools: the Pediatric Yorkhill Malnutrition Score (PYMS) and mid-upper arm circumference (MUAC), with attention to their utility in identifying socio-economic vulnerability. METHODS: This pilot study was conducted between January and July 2024 in a tertiary university hospital in Turkiye. A total of 100 children (50 girls, 50 boys), aged 1 month to 18 years, were evaluated. Nutritional status was assessed using World Health Organization (WHO) anthropometric Z-scores. Malnutrition risk was screened via PYMS and age-adjusted MUAC Z-scores. A novel socio-economic malnutrition risk classification was developed based on household income, family size, and maternal employment status. This pilot study tested the combined use of routine anthropometric measurements and practical screening tools such as PYMS and MUAC for a later large-scale, school-based screening. RESULTS: The double burden of malnutrition was evident: 13.0% had acute malnutrition and 11.0% chronic malnutrition (stunting); among children aged 5-18 years, 34.5% were overweight and 21.8% obese. The LOS was significantly longer in the PYMS high-risk group compared to the low-risk group (p = 0.001), and in the MUAC moderate malnutrition group (p < 0.05). PYMS demonstrated high specificity (95.89%) for acute malnutrition but limited sensitivity for stunting. Among children aged > 5 years, MUAC Z-scores correlated significantly with body mass index (BMI) Z-scores (p < 0.05). Children classified as high-risk by the socio-economic model had significantly lower height-for-age Z-scores (p < 0.05). CONCLUSIONS: This study highlights the impact of socio-economic inequities-such as low income and household overcrowding-on chronic malnutrition and confirms the clinical relevance of the double burden of malnutrition. PYMS and MUAC effectively predict prolonged hospitalization and adverse clinical outcomes. The integration of socio-economic risk assessment with routine malnutrition screening may guide equitable resource allocation and improve care for vulnerable pediatric populations. CI - (c) 2026. The Author(s). FAU - Celik, Emre AU - Celik E AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. abdullahemrecelik@gmail.com. FAU - Korkmaz, Muhammet Furkan AU - Korkmaz MF AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. FAU - Ozkaya, Yunus AU - Ozkaya Y AD - Department of Public Health, Sirnak Provincial Health Directorate, Sirnak, Turkiye. FAU - Yuce, Servet AU - Yuce S AD - Department of Public Health, Istanbul Provincial Health Directorate, Istanbul, Turkiye. FAU - Soyubelli, Tugce Dilara AU - Soyubelli TD AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. FAU - Tutanc, Murat AU - Tutanc M AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. LA - eng PT - Journal Article DEP - 20260903 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - Pilot Projects MH - Child, Preschool MH - Infant MH - Male MH - Child MH - *Length of Stay/statistics & numerical data MH - *Arm/anatomy & histology MH - Adolescent MH - Risk Factors MH - *Child Nutrition Disorders/diagnosis/epidemiology MH - Anthropometry MH - Risk Assessment/methods MH - *Nutrition Assessment MH - Child, Hospitalized MH - Prevalence MH - *Malnutrition/diagnosis/epidemiology MH - Nutritional Status MH - Predictive Value of Tests PMC - PMC13602631 OTO - NOTNLM OT - Health inequities OT - Hospitalized children OT - MUAC OT - Mid-upper arm circumference OT - Nutritional screening OT - PYMS OT - Pediatric malnutrition OT - Socio-economic determinants COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Clinical Research Ethics Committee of Bursa City Hospital (Approval No: 2023-20/3). Our study was conducted according to the Declaration of Helsinki, and Informed written and verbal consent was obtained from all participants or their legal guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/25 05:32 MHDA- 2026/09/25 05:33 PMCR- 2026/09/03 CRDT- 2026/09/24 23:57 PHST- 2026/01/19 00:00 [received] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/25 05:33 [medline] PHST- 2026/09/25 05:32 [pubmed] PHST- 2026/09/24 23:57 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.1186/s12887-026-07609-5 [pii] AID - 7609 [pii] AID - 10.1186/s12887-026-07609-5 [doi] PST - epublish SO - BMC Pediatr. 2026 Sep 3;26(1):905. doi: 10.1186/s12887-026-07609-5. PMID- 42786280 OWN - NLM STAT- Publisher LR - 20260924 IS - 1476-5454 (Electronic) IS - 0950-222X (Linking) DP - 2026 Sep 24 TI - Validation of the DIGIROP 2.0 Models in predicting the risk of treatment-requiring retinopathy of prematurity in a Taiwanese cohort. LID - 10.1038/s41433-026-04856-9 [doi] AB - BACKGROUND: To evaluate the performance of the updated DIGIROP models (version 2.0), which incorporate parenteral nutrition duration (PND; protein and lipids) data, in predicting treatment-requiring retinopathy of prematurity (ROP). METHODS: A retrospective validation study at a tertiary referral centre in Taiwan. The DIGIROP-Birth 2.0 and DIGIROP-Screen 2.0 models were applied to calculate individual risk estimates for treatment-requiring ROP. Model performance was evaluated by assessing sensitivity and specificity. Recalibration was performed based on the incidence of treatment-requiring ROP across different gestational age groups to account for differences between the study and the original developmental cohorts. The performance of the recalibrated models was then compared with that of the original DIGIROP 2.0 models. RESULTS: Among the 303 infants included, 30 required treatment for ROP. The DIGIROP-Birth 2.0 model successfully identified 28 of the treated infants (sensitivity: 93.3% [95% CI: 77.9-99.2]; specificity: 48.0% [95% CI: 41.9-54.1]). The sensitivities of DIGIROP-Screen 2.0 ranged from 93.3% (95% CI: 77.9-99.2) to 100% (95% CI: 63.1-100) during postnatal weeks 6-14. The recalibrated DIGIROP-Birth 2.0 model correctly identified all infants with treatment-requiring ROP (sensitivity: 100.0% [95% CI: 88.4-100]; specificity: 33.3% [95% CI: 27.8-39.3]), as did the recalibrated DIGIROP-Screen 2.0 model across different postnatal weeks. A model developed using gestational age and PND in our cohort yielded 100% (95% CI: 88.4-100) sensitivity and highest specificity (66.7% [95% CI: 60.7-72.2]). CONCLUSIONS: The DIGIROP 2.0 models demonstrated high sensitivities in identifying treatment-requiring ROP in this external validation cohort, particularly after recalibration, underscoring the importance of validation and modification when applying the models to different populations. Further large-scale studies are required to confirm the value of including PND in ROP screening models. CI - (c) 2026. The Author(s), under exclusive licence to The Royal College of Ophthalmologists. FAU - Huang, Ching-Wen AU - Huang CW AD - Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan, ROC. AD - Department of Ophthalmology, Fu Jen Catholic University Hospital, New Taipei City, Taiwan, ROC. FAU - Pivodic, Aldina AU - Pivodic A AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Tsao, Po-Nien AU - Tsao PN AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. AD - Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan, ROC. FAU - Hellstrom, Ann AU - Hellstrom A AUID- ORCID: 0000-0002-9259-1244 AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Yeh, Po-Ting AU - Yeh PT AD - Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Chou, Hung-Chieh AU - Chou HC AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Chen, Chien-Yi AU - Chen CY AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Yen, Ting-An AU - Yen TA AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Huang, Hsin-Chung AU - Huang HC AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Lai, Tso-Ting AU - Lai TT AUID- ORCID: 0000-0002-8247-7018 AD - Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan, ROC. b91401005@ntu.edu.tw. AD - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. b91401005@ntu.edu.tw. LA - eng PT - Journal Article DEP - 20260924 PL - England TA - Eye (Lond) JT - Eye (London, England) JID - 8703986 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/09/25 05:32 MHDA- 2026/09/25 05:32 CRDT- 2026/09/24 23:43 PHST- 2026/02/22 00:00 [received] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/07/29 00:00 [revised] PHST- 2026/09/25 05:32 [medline] PHST- 2026/09/25 05:32 [pubmed] PHST- 2026/09/24 23:43 [entrez] AID - 10.1038/s41433-026-04856-9 [pii] AID - 10.1038/s41433-026-04856-9 [doi] PST - aheadofprint SO - Eye (Lond). 2026 Sep 24. doi: 10.1038/s41433-026-04856-9. PMID- 42785732 OWN - NLM STAT- Publisher LR - 20260924 IS - 1461-7021 (Electronic) IS - 1359-1045 (Linking) DP - 2026 Sep 24 TI - Adolescents in the Digital Age: Phubbing, Parental Phubbing, Emotional Eating, and Emotion Regulation Difficulties. PG - 13591045261491778 LID - 10.1177/13591045261491778 [doi] AB - BackgroundParental smartphone use during parent-child interactions, known as parental phubbing, may negatively affect adolescents' emotional well-being and contribute to psychological maltreatment. However, the mechanisms linking parental phubbing to adolescents' own digital behaviors remain unclear.ObjectiveThis study examined the associations among parental phubbing, adolescent phubbing, emotion regulation difficulties, perceived psychological maltreatment, and emotional eating, and investigated the mediating roles of emotion regulation difficulties and psychological maltreatment.MethodsThe sample included 128 adolescents aged 12-17 years (51.6% female) and their parents. Participants completed validated self-report measures assessing phubbing behaviors, emotion regulation difficulties, psychological maltreatment, and emotional eating. Correlation, multiple regression, and mediation analyses were conducted.ResultsAdolescent phubbing was positively associated with maternal and paternal phubbing, emotion regulation difficulties, paternal psychological maltreatment, and emotional eating (all p < .05). Regression analyses showed that paternal phubbing, emotion regulation difficulties, paternal psychological maltreatment, and gender significantly predicted adolescent phubbing, explaining 40% of the variance. Mediation analyses indicated that emotion regulation difficulties mediated the associations between both maternal and paternal phubbing and adolescent phubbing. Paternal psychological maltreatment also partially mediated the relationship between paternal phubbing and adolescent phubbing.ConclusionsParental phubbing, particularly paternal phubbing, may influence adolescents' digital behaviors through emotion regulation difficulties and perceived psychological maltreatment, highlighting the importance of parental digital habits for adolescent well-being. FAU - Avunduk, Serdar AU - Avunduk S AUID- ORCID: 0000-0003-3337-1927 AD - Department of Child and Adolescent Psychiatry Canakkale Mehmet Akif Ersoy State Hospital, Canakkale, Turkey. FAU - Aksoy Avunduk, Sena AU - Aksoy Avunduk S AUID- ORCID: 0000-0002-3909-5188 AD - Faculty of Medicine, Department of Child and Adolescent Psychiatry, Canakkale Onsekiz Mart University, Canakkale, Turkey. RINGGOLD: 52950 FAU - Gavcar, Erdal Gorkem AU - Gavcar EG AD - Faculty of Medicine, Department of Child and Adolescent Psychiatry, Pamukkale University, Denizli, Turkey. RINGGOLD: 52990 LA - eng PT - Journal Article DEP - 20260924 PL - England TA - Clin Child Psychol Psychiatry JT - Clinical child psychology and psychiatry JID - 9604507 SB - IM OAB - What is this study about? In today's digital era, parents often use their smartphones during moments spent with their children-a behavior known as "parental phubbing." This study explored how parents' phone use affects teenagers' own smartphone habits, their ability to manage negative emotions, their perceptions of emotional neglect within the family, and their tendency to engage in emotional eating. What did the researchers do? The researchers surveyed 128 adolescents aged 12 to 17 and their parents at an outpatient clinic. Participants completed questionnaires assessing parental and adolescent smartphone habits, emotion regulation difficulties, feelings of psychological maltreatment, and emotional eating behaviors. What were the key findings? Parental Influence: Teenagers were more likely to phub others if their mothers and fathers frequently used smartphones around them. The Role of Fathers: Father phubbing emerged as a particularly strong factor. Fathers' device distraction directly predicted higher adolescent phubbing and indirect risks linked to emotional dysregulation and perceived paternal emotional neglect. Emotional Dysregulation: Adolescents who struggled to process negative feelings were significantly more likely to use smartphones as an escape and turn to food to cope with distress. Why do these findings matter? This research highlights that parental digital distraction is not just a mild annoyance; it can function as a form of relational distance that undermines an adolescent's emotional well-being. Interventions should encourage device-free family times and help parents-especially fathers-understand the crucial role emotional availability plays in fostering healthy digital and lifestyle habits in youth. OABL- eng OTO - NOTNLM OT - adolescents OT - emotion regulation OT - emotional eating OT - parental phubbing OT - phubbing OT - psychological maltreatment EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:52 CRDT- 2026/09/24 19:53 PHST- 2026/09/24 23:52 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 19:53 [entrez] AID - 10.1177/13591045261491778 [doi] PST - aheadofprint SO - Clin Child Psychol Psychiatry. 2026 Sep 24:13591045261491778. doi: 10.1177/13591045261491778. PMID- 42785553 OWN - NLM STAT- Publisher LR - 20261007 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 76 DP - 2026 Sep 24 TI - Feeding challenges in pediatric intestinal failure: Insights from three different instruments. PG - 105137 LID - S2405-4577(26)02234-5 [pii] LID - 10.1016/j.clnesp.2026.105137 [doi] AB - BACKGROUND & AIMS: Feeding difficulties are frequently reported in children with intestinal failure (IF) and may represent an important barrier to transition from parenteral nutrition (PN) to enteral autonomy. Appropriate assessment tools are essential for accurate recognition and management of feeding challenges. The objective was to evaluate feeding difficulties using three complementary assessment instruments in children with IF receiving prolonged PN. METHODS: This cross-sectional study included children aged 6 months to 18 years with IF receiving PN for more than two months. Children with oropharyngeal dysphagia, severe neurological disease and severe congenital disorders were excluded. Caregivers completed a structured interview, and three instruments were applied: American Speech-Language-Hearing Association National Outcomes Measurement System (ASHA-NOMS), Montreal Children's Hospital Feeding Scale (MCH-FS), and Schedule for Oral Motor Assessment (SOMA). Cutoff points were defined according to instrument psychometric properties. Results were analyzed by age groups. RESULTS: Fifty-one patients were evaluated (median age 31.8 months, IQR 16.1-58.2; 62.7% male). Feeding abnormalities identified by at least one instrument were present in 52.9% of participants. Abnormalities were detected in 31.4% by MCH-FS and ASHA-NOMS, and 23.5% by SOMA, which identified a significantly higher frequency of abnormalities in children younger than 36 months. CONCLUSION: More than half of children with IF receiving prolonged PN showed feeding abnormalities. Combined tools may improve identification of feeding difficulties and guide individualized interventions. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Signorini, Alana V AU - Signorini AV AD - Post-Graduate Program of Child and Adolescent Health, Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul, Hospital de Clinicas de Porto Alegre, Brazil. Electronic address: alanass@gmail.com. FAU - Pires, Giovana Q AU - Pires GQ AD - Post-Graduate Program of Child and Adolescent Health, Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul, Hospital de Clinicas de Porto Alegre, Brazil. FAU - Ceza, Marilia R AU - Ceza MR AD - Pediatric Gastroenterology Unit, Hospital de Clinicas de Porto Alegre, Brazil. FAU - Adami, Marina R AU - Adami MR AD - Pediatric Gastroenterology Unit, Hospital de Clinicas de Porto Alegre, Brazil. FAU - Kieling, Carlos O AU - Kieling CO AD - Pediatric Gastroenterology Unit, Hospital de Clinicas de Porto Alegre, Brazil. FAU - Goldani, Helena A S AU - Goldani HAS AD - Post-Graduate Program of Child and Adolescent Health, Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul, Hospital de Clinicas de Porto Alegre, Brazil; Pediatric Gastroenterology Unit, Hospital de Clinicas de Porto Alegre, Brazil; Department of Pediatrics - Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul, Hospital de Clinicas de Porto Alegre, Brazil. LA - eng PT - Journal Article DEP - 20260924 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM OTO - NOTNLM OT - Feeding and eating disorders of childhood OT - Food fussiness OT - Parenteral nutrition OT - Short bowel syndrome COIS- Conflict of interest The authors declare no conflict of interest. EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:52 CRDT- 2026/09/24 19:26 PHST- 2026/07/13 00:00 [received] PHST- 2026/09/15 00:00 [revised] PHST- 2026/09/19 00:00 [accepted] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 23:52 [medline] PHST- 2026/09/24 19:26 [entrez] AID - S2405-4577(26)02234-5 [pii] AID - 10.1016/j.clnesp.2026.105137 [doi] PST - aheadofprint SO - Clin Nutr ESPEN. 2026 Sep 24;76:105137. doi: 10.1016/j.clnesp.2026.105137. PMID- 42785235 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261015 IS - 2352-3964 (Electronic) IS - 2352-3964 (Linking) VI - 132 DP - 2026 Oct TI - Serum biomarkers for the diagnosis and management of adolescent polyendocrine metabolic ovarian syndrome: a systematic review and meta-analysis. PG - 106471 LID - S2352-3964(26)00355-5 [pii] LID - 10.1016/j.ebiom.2026.106471 [doi] LID - 106471 AB - BACKGROUND: Adolescent polyendocrine metabolic ovarian syndrome (PMOS) poses immediate and lifelong risks to women's health. However, reliable biomarkers for adolescent PMOS remain elusive in current clinical practice. METHODS: We systematically searched six databases from inception to April 2026, following PRISMA guidelines (PROSPERO No.: CRD420251033057). Eligible studies included adolescents with PMOS and healthy controls. Primary outcomes were effect sizes of serum reproductive hormones, insulin indices, and adipokines (Hedges' g in random-effects models), with diagnostic performance assessed by AUC, sensitivity, and specificity. FINDINGS: Fifty-one moderate-to-high quality studies comprising 4892 adolescents were included. Large effect sizes were observed for total testosterone (TT, 1.10), free androgen index (FAI, 1.19), ratio of luteinising hormone to follicle-stimulating hormone (LH/FSH, 1.07), anti-Mullerian hormone (AMH, 0.98), and adiponectin (-1.12), all with moderate-to-low certainty. Insulin resistance indices (homoeostatic model assessment of insulin resistance [HOMA-IR], 0.64; quantitative insulin sensitivity check index [QUICKI], -0.47) and leptin (0.40) showed small effect sizes with low certainty. In adolescents with obesity, AMH (1.39) and adiponectin (-1.54) showed pronounced effects. For diagnostic performance, TT (cutoff = 55.96 ng/dL), FAI (cutoff = 6.78), and LH/FSH (cutoff = 1.59) each achieved an AUC of 0.74. AMH effectively identified PMOS in obese group (AUC = 0.85, cutoff = 4.47 ng/mL) and the <17-year-old group (AUC = 0.77, cufoff = 6.05 ng/mL). For metabolic stratification, HOMA-IR performed modestly overall AUC of 0.65 (cutoff = 4.35), while adiponectin (AUC = 0.78, cutoff = 10.92 mug/mL) and leptin (AUC = 0.67, cutoff = 36.17 ng/mL) emerged as BMI-dependent markers in obese and non-obese groups, respectively. Of note, LH/FSH and dehydroepiandrosterone sulphate (DHEAS) showed significant publication bias; thus, these results should be interpreted with caution. INTERPRETATION: TT and FAI are primary diagnostic biomarkers in adolescent PMOS, with LH/FSH providing supportive value. AMH is discriminative in adolescents with obesity in early-mid adolescence. HOMA-IR is a primary biomarker for metabolic monitoring, while adiponectin and leptin are BMI-dependent markers for early metabolic risk stratification. FUNDING: This study was supported by HMRF, CUHK direct grant, CUHK-Chulalongkorn University Research Fund, 1 + 1 + 1 CUHK-CUHK(SZ)-GDST Joint Collaboration Fund, and PhD International Mobility for Partnerships and Collaboration Award. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Shi, Yue AU - Shi Y AD - Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China. FAU - Wang, Chi Chiu AU - Wang CC AD - Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China. FAU - Stener-Victorin, Elisabet AU - Stener-Victorin E AD - Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden. FAU - Chung, Pui Wah AU - Chung PW AD - Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China. FAU - Wang, Yao AU - Wang Y AD - Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China. Electronic address: yaowang1@cuhk.edu.hk. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260924 PL - Netherlands TA - EBioMedicine JT - EBioMedicine JID - 101647039 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Biomarkers/blood MH - Adolescent MH - *Metabolic Syndrome/diagnosis/blood/therapy MH - *Polycystic Ovary Syndrome/diagnosis/blood MH - Insulin Resistance PMC - PMC13634440 OTO - NOTNLM OT - Adolescent OT - Biomarker OT - Diagnostic performance OT - Meta-analysis OT - Polycystic ovary syndrome (PCOS) OT - Polyendocrine metabolic ovarian syndrome (PMOS) OT - Risk stratification COIS- Declaration of interests The authors declare that they have no competing interests. EDAT- 2026/09/24 23:52 MHDA- 2026/10/14 23:31 PMCR- 2026/09/24 CRDT- 2026/09/24 18:56 PHST- 2026/02/21 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/10/14 23:31 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 18:56 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - S2352-3964(26)00355-5 [pii] AID - 106471 [pii] AID - 10.1016/j.ebiom.2026.106471 [doi] PST - ppublish SO - EBioMedicine. 2026 Oct;132:106471. doi: 10.1016/j.ebiom.2026.106471. Epub 2026 Sep 24. PMID- 42784400 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260928 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 9 DP - 2026 Sep 14 TI - Classroom Active Breaks Effects on Attention and Concentration Performance Among Adolescents Attending Upper Secondary Schools in Southern Italy. LID - 10.3390/sports14090404 [doi] LID - 404 AB - BACKGROUND: Physical inactivity and prolonged sedentary behavior have been associated with impaired cognitive function during adolescence. Although classroom-based active breaks (ABs) have shown promising effects in primary school children, evidence among adolescents attending upper secondary schools remains limited. This study evaluated the effects of a four-month classroom-based ABs program on attention and concentration performance and explored whether selected participant and lifestyle-related characteristics moderated the intervention response. METHODS: In this cluster-randomized controlled trial, 529 adolescents (302 females, 227 males; 14.3 +/- 0.9 years) from 39 classes attending four upper secondary schools in Southern Italy were included. Classes were randomly allocated to the intervention group (IG; 20 classes, n = 288) or control group (CG; 19 classes, n = 241). The IG participated in two daily 10 min classroom-based ABs for four months, whereas the CG followed the usual school routine. At baseline, anthropometric characteristics, sport participation, sleep duration, daily smartphone use, adherence to the Mediterranean Diet, and concentration performance (CP score), assessed by the d2-R Test of Attention, were evaluated; only CP was reassessed after the intervention. RESULTS: The primary mixed-effects model showed significantly higher adjusted post-intervention CP in the IG than in the CG (adjusted between-group difference = 56.7 points, 95% CI 21.7-91.6; p = 0.003). The intervention effect remained significant in a fully adjusted model including sex, organized sport participation, sleep duration, smartphone use, and Mediterranean Diet adherence (p = 0.004). Exploratory moderator analyses provided no evidence that the intervention effect differed according to any of these characteristics after correction for multiple testing. CONCLUSIONS: A four-month classroom-based ABs program can improve concentration performance among adolescents. High intervention fidelity and student attendance support the feasibility of implementing structured ABs within the school setting over the intervention period. Further research is needed to determine the long-term effects and implementation of ABs program in secondary schools. FAU - Martone, Domenico AU - Martone D AUID- ORCID: 0000-0003-1967-1640 AD - Department of Economics, Law, Cybersecurity and Sport Sciences, University Parthenope, 80133 Naples, Italy. FAU - Vitucci, Daniela AU - Vitucci D AD - Department of Economics, Law, Cybersecurity and Sport Sciences, University Parthenope, 80133 Naples, Italy. FAU - Gillo, Andrea AU - Gillo A AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Dei, Sara AU - Dei S AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Cosco, Loretta Francesca AU - Cosco LF AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Valerio, Giuliana AU - Valerio G AUID- ORCID: 0000-0001-5063-4333 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Ghirelli, Rosa AU - Ghirelli R AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Alfieri, Andreina AU - Alfieri A AUID- ORCID: 0000-0003-1082-1585 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Mancini, Annamaria AU - Mancini A AUID- ORCID: 0000-0002-8595-1387 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Orru, Stefania AU - Orru S AUID- ORCID: 0000-0002-6697-9413 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Buono, Pasqualina AU - Buono P AUID- ORCID: 0000-0003-0755-6143 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. LA - eng GR - I43C23000160005/Parthenope University of Naples/ PT - Journal Article DEP - 20260914 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13611686 OTO - NOTNLM OT - active breaks OT - cognitive performance OT - school-based intervention OT - sedentary behavior OT - upper secondary school COIS- The authors declare no conflicts of interest. EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:53 PMCR- 2026/09/14 CRDT- 2026/09/24 18:20 PHST- 2026/07/18 00:00 [received] PHST- 2026/09/04 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/24 23:53 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 18:20 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - sports14090404 [pii] AID - sports-14-00404 [pii] AID - 10.3390/sports14090404 [doi] PST - epublish SO - Sports (Basel). 2026 Sep 14;14(9):404. doi: 10.3390/sports14090404. PMID- 42783660 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260928 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 3 DP - 2026 Sep 10 TI - Immediate Effects of a Pogo-Jump Microdose on Vertical Jump Performance in Adolescent Basketball Players: A Randomized Crossover Pilot Study. LID - 10.3390/jfmk11030366 [doi] LID - 366 AB - Background and Objectives: Low-volume plyometric conditioning may elicit post-activation performance enhancement (PAPE), but the early response to pogo-jump exercise in adolescent basketball players remains uncertain. This randomized crossover pilot study estimated the effect of adding 24 bilateral pogo jumps to a standardized warm-up on countermovement-jump (CMJ) and drop-jump (DJ) height, compared with time-matched low-intensity walking. Methods: Twenty-seven male basketball players were recruited, and 21 (age, 16.55 +/- 0.88 years) completed both conditions. In randomized order, separated by a 7-day washout, participants performed 3 sets of 8 bilateral pogo jumps with 1 min between sets or approximately 3 min of low-intensity walking. Post-condition jump assessments began after a 1 min recovery and comprised three consecutive CMJs, a 30 s transition, and three consecutive DJs, with all measurements completed within approximately 2 min after each condition. The highest valid trial was retained for each jump type. Period-adjusted treatment effects were estimated using separate linear mixed-effects models, with repeated-measures ANOVA and Wilcoxon analyses retained as sensitivity analyses. Results: The period-adjusted between-condition difference in change was -0.89 cm for CMJ (95% CI, -2.92 to 1.14; p = 0.389) and 0.34 cm for DJ (95% CI, -1.77 to 2.45; p = 0.753). Sensitivity analyses yielded the same overall interpretation. All completers performed the protocol, and perceived exertion was 11.4 +/- 1.2. The pogo-jump protocol showed favorable immediate tolerability, with all completers reporting 0/10 anterior-knee pain immediately after the condition. Conclusions: The pilot estimates did not indicate a detectable group-level improvement in CMJ or DJ height during the early post-conditioning assessment. However, the confidence intervals were compatible with potentially meaningful effects in either direction. The small sample, single dose, single early assessment window, and variable DJ reliability limit the precision and generalizability of the findings. FAU - Garcia-Lucas, Celia AU - Garcia-Lucas C AD - Departamento de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C/Ramon y Cajal, s/n, 46115 Alfara del Patriarca, Spain. FAU - Bivia-Roig, Gemma AU - Bivia-Roig G AUID- ORCID: 0000-0001-7611-5347 AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Pascual-Morales, Ramon AU - Pascual-Morales R AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Escriba-Fuentes, Jorge AU - Escriba-Fuentes J AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Munoz-Martinez, Ivan AU - Munoz-Martinez I AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Samper-Llavador, Sergio AU - Samper-Llavador S AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Llido-Barreres, Francesc Josep AU - Llido-Barreres FJ AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Muzquiz-Barbera, Pedro AU - Muzquiz-Barbera P AUID- ORCID: 0000-0002-9315-0723 AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Lison, Juan Francisco AU - Lison JF AUID- ORCID: 0000-0002-4983-4052 AD - Departamento de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C/Ramon y Cajal, s/n, 46115 Alfara del Patriarca, Spain. AD - Centre of Physiopathology of Obesity and Nutrition (CIBERobn), CB06/03 Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Amer-Cuenca, Juan Jose AU - Amer-Cuenca JJ AUID- ORCID: 0000-0002-3824-8664 AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. LA - eng PT - Journal Article DEP - 20260910 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13608166 OTO - NOTNLM OT - adolescent athletes OT - basketball OT - countermovement jump OT - drop jump OT - plyometric exercise OT - pogo jumps OT - post-activation performance enhancement OT - stretch-shortening cycle COIS- The authors declare no conflicts of interest. EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:53 PMCR- 2026/09/10 CRDT- 2026/09/24 18:15 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/09/24 23:53 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 18:15 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - jfmk11030366 [pii] AID - jfmk-11-00366 [pii] AID - 10.3390/jfmk11030366 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Sep 10;11(3):366. doi: 10.3390/jfmk11030366. PMID- 42783582 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260928 IS - 2079-3200 (Electronic) IS - 2079-3200 (Linking) VI - 14 IP - 9 DP - 2026 Sep 15 TI - Sports Emotional Intelligence and Exercise Adherence in Adolescents: The Chain Mediating Role of Exercise Enjoyment and Exercise Identity. LID - 10.3390/jintelligence14090222 [doi] LID - 222 AB - Objective: This study explores the relationship between sports emotional intelligence and exercise adherence in adolescents and constructs a sequential mediation model through the mediating roles of exercise enjoyment and exercise identity. Methods: Using a school-based cross-sectional survey, 1278 adolescents aged 12-18 years from Anhui, Henan, Guangxi, and Chongqing were recruited and completed the Sports Emotional Intelligence Scale, Exercise Enjoyment Scale, Exercise Identity Scale, and Exercise Adherence Scale. Data were analyzed using Mplus 8.1 and SPSS 25.0. Common method bias was assessed with Harman's single-factor test. The measurement model was tested via confirmatory factor analysis, and chain indirect effects were examined using the bootstrap method. Results: The measurement model demonstrated good fit, and all scales showed satisfactory reliability and validity. (1) Sports emotional intelligence was significantly associated with exercise adherence (beta = 0.44, p < 0.001); (2) exercise enjoyment (indirect effect = 0.109) and exercise identity (indirect effect = 0.094) each mediated the relationship, and the sequential path from sports emotional intelligence through exercise enjoyment to exercise identity and then to adherence was also significant (indirect effect = 0.079), with all bias-corrected bootstrap 95% confidence intervals excluding 0. Conclusion: Sports emotional intelligence was positively associated with exercise adherence in adolescents, and this association was partly explained by indirect associations involving exercise enjoyment and exercise identity. The findings suggest that affective valuation and exercise-related self-concept are important correlates within the proposed model. FAU - Bai, Donghuan AU - Bai D AD - School of Physical Education, Huaibei Normal University, Huaibei 235000, China. FAU - Li, Xuerui AU - Li X AD - School of Physical Education, Chongqing University, Chongqing 400044, China. FAU - Song, Pengwei AU - Song P AD - School of Physical Education, Guangxi Science & Technology Normal University, Laibin 546199, China. FAU - Zhang, Jia AU - Zhang J AUID- ORCID: 0000-0002-0107-7152 AD - School of Physical Education, Chongqing University, Chongqing 400044, China. LA - eng GR - 2025CDJSKZK26/Fundamental Research Funds for the Central Universities/ GR - 2024AH053185/the Anhui Provincial Scientific Research Plan Preparation Project/ PT - Journal Article DEP - 20260915 PL - Switzerland TA - J Intell JT - Journal of Intelligence JID - 101635592 PMC - PMC13608465 OTO - NOTNLM OT - adolescent OT - exercise adherence OT - exercise enjoyment OT - exercise identity OT - sports emotional intelligence COIS- The authors declare no conflicts of interest. EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:53 PMCR- 2026/09/15 CRDT- 2026/09/24 18:14 PHST- 2026/08/19 00:00 [received] PHST- 2026/09/08 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/24 23:53 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 18:14 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - jintelligence14090222 [pii] AID - jintelligence-14-00222 [pii] AID - 10.3390/jintelligence14090222 [doi] PST - epublish SO - J Intell. 2026 Sep 15;14(9):222. doi: 10.3390/jintelligence14090222. PMID- 42781822 OWN - NLM STAT- Publisher LR - 20260924 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) DP - 2026 Sep 24 TI - A Pilot Study of the Feasibility, Acceptability, and Preliminary Outcomes of an Intensive Multidisciplinary Online Intervention Integrating FBT and DBT for Caregivers of Youth With Anorexia Nervosa in China. LID - 10.1002/eat.70216 [doi] AB - OBJECTIVE: This pilot study aimed to examine the feasibility and acceptability of a 12-week intensive, multidisciplinary, synchronous online intervention for caregivers of children and young adults with anorexia nervosa (patient age range: 10-24 years) that integrated Family-Based Therapy (FBT) principles with Dialectical Behavior Therapy (DBT) skills training. A secondary aim was to explore preliminary changes in caregiver and patient outcomes. METHOD: Using a single-arm, pre-post design, 45 caregivers from 26 families (patients' mean age = 16.19 years, SD = 3.57, range = 10-24) completed assessments at baseline (T0), Week 4 (T1), Week 8 (T2), post-intervention (Week 12, T3), and 3-month follow-up (Week 24, T4). The 12-week program (approximately 57 contact hours) comprised weekly theory workshops, multidisciplinary clinical rounds, and skills practice sessions. The primary outcome was caregivers' subjective burden (Zarit Burden Interview, ZBI); secondary outcomes included eating-disorders-related family impact (Eating Disorders Symptom Impact Scale, EDSIS), caregivers' general psychological distress (Depression Anxiety and Stress Scale, DASS-21), and AN patients' Body Mass Index (BMI). Linear mixed models with unstructured covariance structures examined changes over time, with Bonferroni-adjusted pairwise comparisons and Hedges' g effect sizes. RESULTS: The intervention was successfully delivered in an online format and demonstrated acceptable feasibility, with moderate retention across the intervention and follow-up periods. Exploratory clinical analyses suggested significant reductions in caregiver burden (ZBI; F(4, 31.61) = 12.96, p < 0.001) and eating-disorder-related family impact (EDSIS; F(4, 37.19) = 8.78, p < 0.001) over time. Significant improvements emerged by Week 8 and were maintained at follow-up. Patients' BMI also increased significantly across the study period (F(4, 33.95) = 32.65, p < 0.001). In contrast, caregivers' general psychological distress showed no significant improvements relative to baseline. DISCUSSION: This pilot study provides preliminary evidence that an intensive online intervention integrating FBT and DBT can be feasibly delivered and is acceptable to Chinese caregivers of youth with AN. Exploratory findings suggested potential benefits for caregiver burden, eating-disorder-related family impact, and patient BMI; however, the single-arm design precludes conclusions regarding intervention effectiveness. These findings should therefore be considered hypothesis-generating and warrant evaluation in future randomized controlled trials. CI - (c) 2026 Wiley Periodicals LLC. FAU - Zhang, Lei AU - Zhang L AUID- ORCID: 0000-0001-6487-6587 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - OuYang, Hanlai AU - OuYang H AUID- ORCID: 0009-0003-1797-6894 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Ding, Yin AU - Ding Y AUID- ORCID: 0009-0002-7348-4248 AD - Shanghai Zhiai Shenyi Consulting Management Co., Ltd., Shanghai, China. FAU - Peng, Sufang AU - Peng S AUID- ORCID: 0000-0003-2680-9687 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Han AU - Chen H AUID- ORCID: 0009-0009-4328-1440 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Han, Hui AU - Han H AUID- ORCID: 0000-0003-4014-1070 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Gao, Rui AU - Gao R AUID- ORCID: 0000-0001-7709-201X AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Liu, Yue AU - Liu Y AUID- ORCID: 0009-0009-3440-7603 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Mei, Li AU - Mei L AUID- ORCID: 0000-0002-8015-9438 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Yan AU - Chen Y AUID- ORCID: 0000-0001-8711-215X AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Han, Huiqin AU - Han H AUID- ORCID: 0000-0002-7278-097X AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Gu, Lian AU - Gu L AUID- ORCID: 0000-0002-3699-8250 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Jue AU - Chen J AUID- ORCID: 0000-0002-9924-2573 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. LA - eng GR - 82471573/National Natural Science Foundation of China/ GR - SHDC12023122/Shanghai Hospital Development Center/ GR - 2024-YJ07/Shanghai Mental Health Center/ GR - 2022KTM033/China Medicine Education Association/ PT - Journal Article DEP - 20260924 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM OTO - NOTNLM OT - anorexia nervosa OT - caregivers OT - dialectical behavior therapy OT - family based therapy OT - online intervention OT - subjective burden EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:52 CRDT- 2026/09/24 17:15 PHST- 2026/09/06 00:00 [revised] PHST- 2026/06/24 00:00 [received] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/24 23:52 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 17:15 [entrez] AID - 10.1002/eat.70216 [doi] PST - aheadofprint SO - Int J Eat Disord. 2026 Sep 24. doi: 10.1002/eat.70216. PMID- 42781539 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260926 IS - 1178-6965 (Print) IS - 1178-6965 (Electronic) IS - 1178-6965 (Linking) VI - 19 DP - 2026 TI - Potential Determinants of Progression from Cough-Variant Asthma to Classic Asthma in Children: Evidence, Mechanisms, and Clinical Research Gaps. PG - 644110 LID - 10.2147/JAA.S644110 [doi] LID - 644110 AB - OBJECTIVE: To synthesize current evidence on host and environmental factors potentially associated with progression of cough variant asthma (CVA) to classic asthma in children, with explicit distinction between direct evidence from pediatric CVA cohorts and indirect evidence extrapolated from general asthma or adult studies, and to identify research gaps for future investigation. DATA SOURCES: PubMed, EMBASE, and Web of Science were searched for studies examining CVA progression, risk factors, and mechanisms in pediatric populations. STUDY SELECTIONS: Original research articles, meta-analyses, and systematic reviews investigating genetic susceptibility, atopy, airway hyperresponsiveness, medication adherence, diet, psychological stress, respiratory infections, allergen exposure, and indoor air pollution in relation to CVA-to-classic asthma progression in children aged <18 years were included. RESULTS: Atopy and airway hyperresponsiveness carry the most consistent evidence. Poor medication adherence is the most readily modifiable risk factor. Environmental triggers include respiratory viral infections (particularly rhinovirus), allergen exposure, and indoor air pollution. These factors converge on Th2-biased immunity, epithelial barrier dysfunction, neuroimmune interactions, and epigenetic reprogramming. A nomogram integrating clinical variables and biomarkers achieved AUCs of 0.929 and 0.914 in training and validation cohorts, respectively, but validated prediction tools for CVA progression remain unavailable. CONCLUSION: Early identification of high-risk children through integrated clinical and biomarker assessment, combined with comprehensive management targeting modifiable risk factors, remains the most rational approach to symptom control, exacerbation prevention, and preservation of lung function; whether this delays progression awaits validation in pediatric interventional trials. CI - (c) 2026 Zheng et al. FAU - Zheng, Kaiwen AU - Zheng K AD - Graduate School, Hebei Medical University, Shijiazhuang, Hebei, 050011, People's Republic of China. AD - Department No. 3 of Respiratory Medicine, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. FAU - Ma, Ran AU - Ma R AD - Graduate School, Hebei Medical University, Shijiazhuang, Hebei, 050011, People's Republic of China. AD - Department No. 3 of Respiratory Medicine, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. FAU - Zhang, Yingqian AU - Zhang Y AD - Department No. 3 of Respiratory Medicine, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. AD - Hebei Provincial Clinical Research Center for Child Health and Disease, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. AD - Hebei Key Laboratory of Pediatric Allergy and Immunology, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. LA - eng PT - Journal Article PT - Review DEP - 20260919 PL - New Zealand TA - J Asthma Allergy JT - Journal of asthma and allergy JID - 101543450 PMC - PMC13599799 OTO - NOTNLM OT - airway inflammation OT - asthma OT - child OT - cough variant asthma OT - disease progression OT - risk factors COIS- The authors declare that they have no competing interests. EDAT- 2026/09/24 17:31 MHDA- 2026/09/24 17:32 PMCR- 2026/09/19 CRDT- 2026/09/24 16:52 PHST- 2026/07/28 00:00 [received] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/09/24 17:32 [medline] PHST- 2026/09/24 17:31 [pubmed] PHST- 2026/09/24 16:52 [entrez] PHST- 2026/09/19 00:00 [pmc-release] AID - 644110 [pii] AID - 10.2147/JAA.S644110 [doi] PST - epublish SO - J Asthma Allergy. 2026 Sep 19;19:644110. doi: 10.2147/JAA.S644110. eCollection 2026. PMID- 42781358 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260926 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Advancing early identification of at-risk children: a consensus-based refinement and validation roadmap for the pediatric malnutrition screening algorithm. PG - 1857903 LID - 10.3389/fnut.2026.1857903 [doi] LID - 1857903 AB - INTRODUCTION: Mild malnutrition risk remains an underrecognized yet clinically important contributor to impaired growth and development in children aged 1-10 years across the Middle East. Regional estimates indicate that 15-25% of children in the Gulf Cooperation Council (GCC) fall within the mild malnutrition risk category (Weight-for-Height Z-score [WHZ] between -1 and -2 SD), a subgroup vulnerable to progressive growth faltering yet excluded from conventional malnutrition diagnostic thresholds (WHZ < -2 SD). The Pediatric Malnutrition Screening Algorithm (PMSA-2025) was refined through a structured regional expert consensus process to enable early, standardized detection of these at-risk children in outpatient and community healthcare settings. METHODS: A 14-member multidisciplinary expert panel from different countries (KSA, UAE, Egypt, Kuwait, Oman, Russia, United States, and Turkiye) refined the PMSA-2025 using a three-round, hybrid modified Delphi approach conducted in September 2025. Expert selection criteria included a minimum of 10 years of clinical or academic experience in pediatric nutrition or gastroenterology, active involvement in malnutrition-related clinical practice or research, and representation of diverse regional healthcare contexts. Content validity was assessed using the Item-level Content Validity Index (I-CVI), with a threshold of >/=0.80 for domain retention. Six clinical domains were retained from an initial pool of eight candidate domains after Delphi-based consensus: perinatal history, growth trajectory, prior nutritional diagnosis, hospitalization frequency, infection recurrence, and feeding behavior. Each domain was operationalized with measurable, age-appropriate criteria and incorporated into a binary (Yes/No) scoring system (total score: 0-6). The tool is designed for use by pediatricians, family physicians, nurses, and trained community health workers in children aged 1-10 years with WHZ between -1 and -2 SD. Exclusion criteria include children with primary chronic systemic disease driving growth impairment and those already receiving formal nutritional support. RESULTS: All six retained domains achieved an Item-level CVI (I-CVI) >/= 0.85 in the final consensus round. Two initial candidate domains (dietary diversity score, caregiver nutritional literacy) were excluded due to insufficient agreement (I-CVI < 0.70). Three domains required definitional refinement during Round 2, achieving >/=90% final agreement in Round 3. The PMSA-2025 stratifies mild malnutrition risk across three tiers: low (0-1), moderate (2-3), and high (4-6). It requires no specialized equipment beyond a standard scale and can be completed within routine consultations. CONCLUSION: The PMSA-2025 represents a consensus-based, multidimensional screening tool with established content validity designed to address the unmet need for early mild malnutrition risk identification in outpatient and community pediatric settings across the Middle East. CI - Copyright (c) 2026 Murray, Shaaban, Shamsah, Al Hammadi, Amin, Almehaidib, Elkhashab, Pyrieva, Al Hammadi, Cetin, Al-Said, AlSaadi, Kamal and ElBaroudy. FAU - Murray, Robert D AU - Murray RD AD - Emeritus Professor of Pediatrics, Pediatric GI and Nutrition, The Ohio State University School of Medicine, Columbus, OH, United States. FAU - Shaaban, Sanaa Y AU - Shaaban SY AD - Professor of Pediatrics, Department of Pediatrics, Consultant of Pediatric Clinical Nutrition, Ain Shams University, Cairo, Egypt. FAU - Shamsah, Abdullah AU - Shamsah A AD - President of Kuwait Pediatric Association, Kuwait, Kuwait. AD - Pediatric & Pediatric Emergency Consultant, Ministry of Health, Kuwait, Kuwait. FAU - Al Hammadi, Ahmed AU - Al Hammadi A AD - Dubai Health Authority, Dubai Medical College, Dubai, United Arab Emirates. FAU - Amin, Ahmed AU - Amin A AD - Abbott Laboratories, Dubai, United Arab Emirates. FAU - Almehaidib, Ali AU - Almehaidib A AD - King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. FAU - Elkhashab, Ehab Khairy AU - Elkhashab EK AD - Pediatric Clinical Nutrition Unit, Ain Shams University, Cairo, Egypt. FAU - Pyrieva, Ekaterina A AU - Pyrieva EA AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia. FAU - Al Hammadi, Entesar AU - Al Hammadi E AD - Dubai Health Authority, Dubai Medical College, Dubai, United Arab Emirates. FAU - Cetin, Funda AU - Cetin F AD - Ege University Faculty of Medicine, Department of Pediatrics, Izmir, Turkiye. FAU - Al-Said, Khoula AU - Al-Said K AD - Department of Paediatric Gastroenterology, Royal Hospital, Muscat, Oman. FAU - AlSaadi, Muslim AU - AlSaadi M AD - Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - Kamal, Naglaa M AU - Kamal NM AD - Department of Pediatrics and Pediatric Hepatology, Kasr Al-Ainy Faculty of Medicine, Cairo, Egypt. FAU - ElBaroudy, Eslam Tawfik AU - ElBaroudy ET AD - Department of Pediatrics, Faculty of Medicine, University of Suez, Suez, Egypt. AD - Department of Health, Kids Heart Medical Center affiliated Columbia University, Abu Dhabi, United Arab Emirates. LA - eng PT - Journal Article PT - Review DEP - 20260909 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13598915 OTO - NOTNLM OT - Middle East OT - Z-score OT - content validity OT - early detection OT - growth monitoring OT - malnutrition OT - pediatric nutrition OT - screening COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author NK declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/24 17:31 MHDA- 2026/09/24 17:32 PMCR- 2026/09/09 CRDT- 2026/09/24 16:19 PHST- 2026/04/16 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/24 17:32 [medline] PHST- 2026/09/24 17:31 [pubmed] PHST- 2026/09/24 16:19 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fnut.2026.1857903 [doi] PST - epublish SO - Front Nutr. 2026 Sep 9;13:1857903. doi: 10.3389/fnut.2026.1857903. eCollection 2026. PMID- 42780596 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260927 IS - 3005-0774 (Print) IS - 3005-0774 (Electronic) IS - 3005-0774 (Linking) VI - 23 IP - 1 DP - 2026 TI - Presence of a trusted adult and adolescent health outcomes in Urban India. PG - 1496 LID - 10.1186/s12982-026-02849-3 [doi] LID - 1496 AB - BACKGROUND: Adolescents in urban India face significant challenges in accessing healthcare and reliable health information, particularly during crises such as the COVID-19 pandemic. However, the role of trusted adults in shaping adolescent health remains underexplored. OBJECTIVES: This study examined healthcare access, health information exposure, and the influence of trusted adults among urban Indian adolescents during the COVID-19 pandemic. METHODS: A cross-sectional online survey was conducted with 784 adolescents aged 10-19 years across urban India during the second wave of COVID-19 (May-October 2021). The survey assessed mental health, healthcare access, sources of health information, and the presence of trusted adults. Multivariable logistic regression models were used to examine associations between trusted adults and key health (and related) outcomes, adjusting for age, gender, and type of school. RESULTS: Most adolescents (85.2%) reported having a trusted adult. Adolescents with a trusted adult had significantly higher odds of accessing a healthcare provider (AOR = 1.98, p = 0.001) and receiving information on mental health (AOR = 2.38, p < 0.001), nutrition (AOR = 1.79, p = 0.005), and COVID-19 (AOR = 1.91, p = 0.003). The presence of a trusted adult was strongly associated with lower psychological distress during (AOR = 0.40, p < 0.001) and before (AOR = 0.43, p < 0.001) the pandemic. No significant association was found with telehealth use or access to sensitive health information such as sexual and reproductive health. CONCLUSIONS: In this cross-sectional sample of urban, school-enrolled Indian adolescents surveyed during COVID-19, reporting a trusted adult was associated with greater healthcare access, wider exposure to general health information, and lower psychological distress, though not with telehealth use or with information on sensitive topics. These associations cannot establish causation, but they suggest that the supportive relationships adolescents already have merit closer attention, and better measurement, alongside the infrastructural focus of current adolescent health programs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at https://doi.org/10.1186/s12982-026-02849-3. CI - (c) The Author(s) 2026. FAU - Sharma, Anupam AU - Sharma A AD - Adolescent Health Champions (AHC), San Francisco, CA USA. FAU - Shankar, Priya AU - Shankar P AD - Johns Hopkins University, Maryland, USA. ROR: https://ror.org/00za53h95. GRID: grid.21107.35. ISNI: 0000 0001 2171 9311 FAU - Sharma, Ricky AU - Sharma R AD - Adolescent Health Champions (AHC), San Francisco, CA USA. FAU - Krishna, Nelabh AU - Krishna N AD - Adolescent Health Champions (AHC), San Francisco, CA USA. FAU - Jayakumar, Nanditha AU - Jayakumar N AD - Adolescent Health Champions (AHC), San Francisco, CA USA. FAU - Nalawade, Samruddhi AU - Nalawade S AD - Adolescent Health Champions (AHC), San Francisco, CA USA. FAU - Doshi, Avani AU - Doshi A AD - Adolescent Health Champions (AHC), San Francisco, CA USA. FAU - Nannapaneni, Aruna AU - Nannapaneni A AD - Adolescent Health Champions (AHC), San Francisco, CA USA. FAU - Krishnan, Vandana AU - Krishnan V AD - Adolescent Health Champions (AHC), San Francisco, CA USA. FAU - Danish, Mohammed AU - Danish M AD - Adolescent Health Champions (AHC), San Francisco, CA USA. FAU - Ahrens, Kym AU - Ahrens K AD - Department of Pediatrics Adolescent Medicine, University of Washington, Washington, USA. ROR: https://ror.org/00cvxb145. GRID: grid.34477.33. ISNI: 0000 0001 2298 6657 FAU - Golub, Sarah AU - Golub S AD - Department of Pediatrics Adolescent Medicine, Seattle Children's Hospital, Washington, USA. ROR: https://ror.org/01njes783. GRID: grid.240741.4. ISNI: 0000 0000 9026 4165 FAU - Dasgupta, Rajib AU - Dasgupta R AD - Jawaharlal Nehru University, New Delhi, India. ROR: https://ror.org/0567v8t28. GRID: grid.10706.30. ISNI: 0000 0004 0498 924X FAU - Ravichandran, Latha AU - Ravichandran L AD - Sri Ramachandra Institute of Higher Education and Research, Chennai, India. ROR: https://ror.org/0108gdg43. GRID: grid.412734.7. ISNI: 0000 0001 1863 5125 FAU - Srikanth, Padma AU - Srikanth P AD - Sri Ramachandra Institute of Higher Education and Research, Chennai, India. ROR: https://ror.org/0108gdg43. GRID: grid.412734.7. ISNI: 0000 0001 1863 5125 FAU - Premkumar, Sarala AU - Premkumar S AD - Sri Ramachandra Institute of Higher Education and Research, Chennai, India. ROR: https://ror.org/0108gdg43. GRID: grid.412734.7. ISNI: 0000 0001 1863 5125 FAU - Nagata, Jason M AU - Nagata JM AD - Department of Pediatrics, University of California, San Francisco, USA. ROR: https://ror.org/043mz5j54. GRID: grid.266102.1. ISNI: 0000 0001 2297 6811 FAU - Keswani, Vaishali AU - Keswani V AD - Kalawati Saran Children's Hospital, New Delhi, India. ROR: https://ror.org/04ty7jx71. GRID: grid.497270.f. ISNI: 0000 0004 1767 7210 AD - Lady Hardinge Medical College, New Delhi, India. ROR: https://ror.org/03x8jdc94. GRID: grid.415723.6 AD - University of Delhi, New Delhi, India. ROR: https://ror.org/04gzb2213. GRID: grid.8195.5. ISNI: 0000 0001 2109 4999 FAU - Allen, Isabel AU - Allen I AD - Bay View Analytics, Oakland, CA USA. AD - Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. ROR: https://ror.org/043mz5j54. GRID: grid.266102.1. ISNI: 0000 0001 2297 6811 FAU - Seaman, Julia AU - Seaman J AD - Bay View Analytics, Oakland, CA USA. FAU - Pemde, Harish AU - Pemde H AD - Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India. ROR: https://ror.org/03x8jdc94. GRID: grid.415723.6 LA - eng GR - D43 TW009345/TW/FIC NIH HHS/United States GR - T32 HD052459/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260922 PL - England TA - Discov Public Health JT - Discover public health JID - 9918863331406676 PMC - PMC13597644 OTO - NOTNLM OT - Adolescent healthcare OT - Adolescents OT - COVID-19 OT - Health information OT - Trusted adults COIS- Competing interestsThe authors declare no competing interests. EDAT- 2026/09/24 17:31 MHDA- 2026/09/24 17:32 PMCR- 2026/09/22 CRDT- 2026/09/24 13:10 PHST- 2026/04/04 00:00 [received] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/24 17:32 [medline] PHST- 2026/09/24 17:31 [pubmed] PHST- 2026/09/24 13:10 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - 2849 [pii] AID - 10.1186/s12982-026-02849-3 [doi] PST - ppublish SO - Discov Public Health. 2026;23(1):1496. doi: 10.1186/s12982-026-02849-3. Epub 2026 Sep 22. PMID- 42780480 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260926 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Maternal-fetal adipokine remodeling in obesity-complicated pregnancies: associations with neonatal macrosomia and NICU requirement. PG - 1904956 LID - 10.3389/fendo.2026.1904956 [doi] LID - 1904956 AB - INTRODUCTION: Maternal obesity is associated with altered maternal-fetal adipokine profiles and adverse early neonatal outcomes. This study aimed to characterize maternal and fetal adipokine patterns across obesity severity groups and to evaluate their associations with macrosomia and neonatal intensive care unit (NICU) requirement. METHODS: In this prospective study, 126 singleton pregnancies were stratified into normal-weight, class I obesity, and class II-III obesity groups (n=42 each). Maternal venous and fetal cord blood adiponectin, leptin, asprosin, fetuin-A, retinol-binding protein-4 (RBP-4), adipsin, and glucose transporter-1 (GLUT-1) were assessed at delivery. Macrosomia and NICU requirement were evaluated using group comparisons, receiver operating characteristic (ROC) analyses, and multivariable logistic regression models. RESULTS: Maternal and fetal adipokine profiles differed significantly across obesity severity groups. Maternal fetuin-A, RBP-4, and adipsin levels, along with fetal leptin, fetuin-A, RBP-4, adipsin, and GLUT-1 levels, increased significantly with increasing obesity severity. In ROC analyses, fetal adipsin showed the highest discrimination for macrosomia (AUC=0.951), whereas fetal RBP-4 showed the highest discrimination for NICU requirement (AUC=0.781). In exploratory adjusted analyses, fetal adipsin remained associated with macrosomia (adjusted OR=5.43, 95% CI 2.14-13.77), whereas fetal RBP-4 remained statistically associated with NICU requirement (adjusted OR=3.31, 95% CI 1.87-5.86). DISCUSSION: Maternal obesity is accompanied by distinct maternal and fetal adipokine remodeling at delivery, with fetal adipsin and RBP-4 showing outcome-specific associations with neonatal macrosomia and NICU requirement, respectively. The compartment-specific biomarker patterns further suggest that the fetal metabolic response to increasing maternal adiposity is not simply a reflection of maternal circulating profiles. These exploratory findings warrant validation in larger, independent cohorts. CI - Copyright (c) 2026 Aslaner, Melekoglu, Yasar, Polat, Yilmaz and Basak Turkmen. FAU - Aslaner, Kubra Nur AU - Aslaner KN AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Melekoglu, Rauf AU - Melekoglu R AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Yasar, Seyma AU - Yasar S AD - Department of Biostatistics and Medical Informatics, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Polat, Busra Berfin AU - Polat BB AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Yilmaz, Ercan AU - Yilmaz E AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Basak Turkmen, Nese AU - Basak Turkmen N AD - Faculty of Pharmacy, Inonu University, Malatya, Turkiye. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Adipokines) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Adipokines/blood MH - *Fetal Macrosomia/blood/etiology/metabolism MH - Infant, Newborn MH - Adult MH - Prospective Studies MH - Fetal Blood/metabolism MH - *Intensive Care Units, Neonatal/statistics & numerical data MH - Biomarkers/blood MH - *Pregnancy in Obesity/blood MH - *Obesity/complications MH - *Pregnancy Complications/blood PMC - PMC13597342 OTO - NOTNLM OT - adipokines OT - adipsin OT - fetuin-A OT - fetus OT - leptin OT - obesity OT - pregnancy OT - retinol-binding protein 4 COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 17:31 MHDA- 2026/09/24 17:32 PMCR- 2026/09/09 CRDT- 2026/09/24 12:23 PHST- 2026/06/09 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/24 17:32 [medline] PHST- 2026/09/24 17:31 [pubmed] PHST- 2026/09/24 12:23 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fendo.2026.1904956 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 9;17:1904956. doi: 10.3389/fendo.2026.1904956. eCollection 2026. PMID- 42780342 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260925 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Effects of different types of physical exercise interventions on aggressive behavior among children and adolescents: a network meta-analysis. PG - 1927181 LID - 10.3389/fpsyg.2026.1927181 [doi] LID - 1927181 AB - INTRODUCTION: Aggressive behavior is a common and important externalizing problem during childhood and adolescence, closely associated with poor social adjustment, subpar academic performance, and adverse mental health outcomes. Although physical exercise has been regarded as a viable nonpharmacological intervention to reduce aggressive behavior, the relative effects of different types of exercise interventions remain unclear. This study used a systematic review and network meta-analysis to compare how different types of physical exercise interventions affect aggression-related outcomes in children and adolescents. METHODS: A systematic literature search across PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure from database inception to December 10, 2025 identified randomized controlled trials (RCTs) and non-randomized controlled trials (non-RCTs) evaluating the effects of physical exercise interventions on aggression-related outcomes in children and adolescents. Based on motor skill characteristics and intervention composition, the interventions were classified into open-skill exercise (OSE), closed-skill exercise (CSE), and multicomponent exercise (MCE). Outcome measures comprised overall aggression, anger, hostility, physical aggression, and verbal aggression. Random effects models were used to conduct conventional pairwise meta-analyses and network meta-analyses, expressing effect sizes as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Surface under the cumulative ranking curve (SUCRA) values determined intervention rankings, and consistency tests, meta-regression, and sensitivity analyses evaluated finding robustness. RESULTS: This analysis included 25 studies involving 2,772 children and adolescents. Compared with control conditions, physical exercise interventions significantly mitigated negative aggression-related outcomes, including hostility (SMD = -0.37, 95% CI: -0.62 to -0.13), anger (SMD = -0.64, 95% CI: -1.00 to -0.27), overall aggression (SMD = -0.87, 95% CI: -1.36 to -0.39), and physical aggression (SMD = -0.70, 95% CI: -0.91 to -0.49). Conversely, the mitigation of verbal aggression lacked statistical significance (SMD = -0.05, 95% CI: -0.36 to 0.25). For outcomes permitting treatment network construction, the global consistency test indicated no significant inconsistency. SUCRA ranking results revealed that MCE ranked highest for hostility (79.4%) and physical aggression (74.7%), CSE ranked highest for anger (85.9%), and OSE ranked highest for overall aggression (84.4%). Meta-regression identified no significant moderators. CONCLUSION: Physical exercise interventions may help improve certain aggression-related outcomes in children and adolescents, although the effects are not entirely consistent across different outcomes. These findings suggest that exercise modalities possessing different skill characteristics may differ in their effects on hostility, anger, overall aggression, and physical aggression. Consequently, practitioners designing interventions for aggressive behavior in children and adolescents may consider the target outcome when selecting exercise programs. Given the substantial between-study heterogeneity and scarce head-to-head comparative evidence, additional high-quality RCTs are needed to validate these findings further. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD42026133695, identifier (CRD420261336959). CI - Copyright (c) 2026 Zhang and Lee. FAU - Zhang, Yuhang AU - Zhang Y AD - Department of Physical Education, Kyungpook National University, Daegu, Republic of Korea. FAU - Lee, Gyuil AU - Lee G AD - Department of Physical Education, Kyungpook National University, Daegu, Republic of Korea. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260909 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13597820 OTO - NOTNLM OT - aggressive behavior OT - children and adolescents OT - network meta-analysis OT - physical exercise interventions OT - systematic review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 12:49 MHDA- 2026/09/24 12:50 PMCR- 2026/09/09 CRDT- 2026/09/24 11:02 PHST- 2026/07/03 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/24 12:50 [medline] PHST- 2026/09/24 12:49 [pubmed] PHST- 2026/09/24 11:02 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1927181 [doi] PST - epublish SO - Front Psychol. 2026 Sep 9;17:1927181. doi: 10.3389/fpsyg.2026.1927181. eCollection 2026. PMID- 42780328 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260925 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Body mass index is positively associated with flatfoot and inversely associated with hindfoot valgus in school-aged children: a cross-sectional analysis of 3,292 screening records. PG - 1930830 LID - 10.3389/fped.2026.1930830 [doi] LID - 1930830 AB - BACKGROUND: A higher body mass index (BMI) has been associated with pediatric flatfoot, but it is unclear whether BMI relates similarly to arch morphology, hallux alignment, and hindfoot alignment when these measures are collected within the same school-screening workflow. Herein, we examined phenotype-specific associations between BMI and three scanner-derived foot measures. METHODS: This secondary cross-sectional analysis linked project-based school foot-screening records to on-site anthropometric measurements. After linkage and quality-control exclusions, 3,292 records from six primary schools were analyzed. Record-level outcomes were moderate-to-severe flatfoot (arch index >/= 0.28), mild hallux valgus (15 degrees to <30 degrees ), and moderate-to-severe hindfoot valgus (>/=4 degrees ), with positivity defined by either foot. BMI was analyzed in sample-specific quartiles and per 1 internal SD. Multivariable binary logistic regression adjusted for age, sex, and school; threshold and duplicate-identifier sensitivity analyses were performed. RESULTS: The 3,292 records represented 3,266 unique school-student identifiers; median age was 10 years (IQR: 9-12), and There were 1,616 female records (49.1%). Screening prevalence was 64.3% for flatfoot, 11.5% for mild hallux valgus, and 52.8% for hindfoot valgus. Each 1-SD higher BMI (4.73 kg/m(2)) was associated with higher odds of flatfoot [odds ratio (OR): 1.37, 95% CI: 1.26-1.49; P < 0.001] and lower odds of hindfoot valgus (OR: 0.82, 95% CI: 0.76-0.88; P < 0.001), while mild hallux valgus showed no statistically significant association (OR: 0.93, 95% CI: 0.82-1.05; P = 0.244). More stringent threshold analyses and analyses retaining one record per identifier produced materially similar BMI associations. CONCLUSIONS: BMI was positively associated with flatfoot and inversely associated with hindfoot valgus, while no significant association was observed for mild hallux valgus. These cross-sectional associations describe operational scanner-derived screening phenotypes and should not be interpreted as causal effects or clinical diagnoses. Prospective studies with documented anthropometric quality control and validated clinical or radiographic measures are needed. CI - (c) 2026 Li, Li, Huo, Xu, Wang, Zhou, Dong, Song, Yang and Wang. FAU - Li, Shanyuan AU - Li S AD - Department of Rehabilitation, Tangshan Second Hospital, Tangshan, Hebei, China. AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Li, Dongmei AU - Li D AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Huo, Yongxin AU - Huo Y AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Xu, Ying AU - Xu Y AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Wang, Yuhang AU - Wang Y AD - Tianjin Delijie Medical Devices Co., Ltd., Tianjin, China. FAU - Zhou, Hongyan AU - Zhou H AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Dong, Xinyang AU - Dong X AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Song, Ying AU - Song Y AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Yang, Weixin AU - Yang W AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Wang, Bin AU - Wang B AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13597771 OTO - NOTNLM OT - body mass index OT - flatfoot OT - hallux valgus OT - hindfoot valgus OT - pediatric orthopedics OT - school screening COIS- YW was employed by Tianjin Delijie Medical Devices Co., Ltd., the manufacturer of the foot analysis instrument used in this study. The remaining author(s) declared that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 12:49 MHDA- 2026/09/24 12:50 PMCR- 2026/09/09 CRDT- 2026/09/24 10:58 PHST- 2026/07/07 00:00 [received] PHST- 2026/08/11 00:00 [revised] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/24 12:50 [medline] PHST- 2026/09/24 12:49 [pubmed] PHST- 2026/09/24 10:58 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fped.2026.1930830 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 9;14:1930830. doi: 10.3389/fped.2026.1930830. eCollection 2026. PMID- 42780256 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260925 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Interpretable skeleton-based movement profiles for formative feedback in school physical activity education. PG - 1925220 LID - 10.3389/fpubh.2026.1925220 [doi] LID - 1925220 AB - BACKGROUND: Schools are an important setting for developing movement competence and supporting physical activity PA). Teachers provide feedback on how learners move, but individualized observation is difficult to sustain and document in large classes. Existing artificial intelligence (AI) systems typically classify an action or predict one competitive-sport score. These outputs do not identify the specific movement feature that a learner might adjust during practice. METHODS: Using three public human action datasets (NTU RGB+D, Penn Action, and a FineGym subset), we benchmarked five representative skeleton-sequence models-recurrent (LSTM, GRU), graph-based (ST-GCN, CTR-GCN), and a Transformer-under a unified setting, and constructed four interpretable movement-profile indicators from joint coordinates and trajectories: movement amplitude, postural stability, left-right coordination, and temporal consistency. Each indicator was normalized against the same-class reference distribution, providing a relative, interpretable description rather than an expert-certified score. RESULTS: Over five random seeds per dataset, independent-test macro-F1 ranged from 0.76 to 0.97; CTR-GCN obtained the highest mean on every dataset (NTU RGB+D 0.970 +/- 0.003). Paired tests supported its advantage over all four comparators on NTU RGB+D and FineGym, whereas on Penn Action only the comparison with LSTM remained significant after correction. In the feature ablation, the full kinematic input increased macro-F1 from 0.925 to 0.936 on 3D skeletons (Holm-adjusted p = 0.022); the corresponding 2D change from 0.893 to 0.905 was not significant after correction (p = 0.079). Per-action profiles and a same-action case analysis showed that the indicators capture interpretable kinematic structure. The resulting percentiles describe relative tendencies within these datasets; a low percentile does not by itself identify an incorrect movement or constitute an age-appropriate standard for children. CONCLUSION: Skeleton-only movement profiles offer a privacy-reducing, teacher-in-the-loop approach to formative feedback that could support digital PA education and health promotion in schools. As a computational proof-of-concept evaluated on public datasets, the study does not include health or learning outcomes, age-specific K-12 reference distributions, or authentic-classroom validation. Calibration on curriculum-relevant data from children and validation against teacher or movement-expert ratings are required before the profiles can be interpreted as movement-quality feedback or used to support public-health claims. CI - Copyright (c) 2026 Ma, Lei, Li, Yang, Du, Zhu, Zhao and Jia. FAU - Ma, Qixuan AU - Ma Q AD - University of Macau, Taipa, Macau SAR, China. FAU - Lei, Xiao AU - Lei X AD - University of Macau, Taipa, Macau SAR, China. FAU - Li, Feng AU - Li F AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd, Hangzhou, China. FAU - Yang, Chengmao AU - Yang C AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. FAU - Du, Jinsui AU - Du J AD - Xiguan Guangya Experimental School, Liwan District, Guangzhou, China. FAU - Zhu, Jiaxing AU - Zhu J AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd, Hangzhou, China. FAU - Zhao, Dongxin AU - Zhao D AD - Shaanxi University of Technology, Hanzhong, China. FAU - Jia, Zhenghu AU - Jia Z AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd, Hangzhou, China. AD - State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Schools MH - *Physical Education and Training/methods MH - *Exercise/physiology MH - *Formative Feedback MH - Movement/physiology MH - Artificial Intelligence MH - Child PMC - PMC13597747 OTO - NOTNLM OT - digital health education OT - formative feedback OT - knowledge of performance OT - movement competence OT - physical activity promotion OT - school physical activity education OT - skeleton-based action recognition COIS- FL, JZ, and ZJ were employed by Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 12:49 MHDA- 2026/09/24 12:50 PMCR- 2026/09/09 CRDT- 2026/09/24 10:27 PHST- 2026/07/01 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/24 12:50 [medline] PHST- 2026/09/24 12:49 [pubmed] PHST- 2026/09/24 10:27 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1925220 [doi] PST - epublish SO - Front Public Health. 2026 Sep 9;14:1925220. doi: 10.3389/fpubh.2026.1925220. eCollection 2026. PMID- 42780105 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260925 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Sociocultural considerations in food addiction and emotional eating: comparative evidence from college students in the United States and South Korea. PG - 1890961 LID - 10.3389/fpubh.2026.1890961 [doi] LID - 1890961 AB - Food addiction and emotional eating are two eating-related constructs that have been linked to obesity and poor mental health, but the extent to which they reliably co-occur across different cultural contexts is less clear. Given that sociocultural norms and food environments differ between countries, this study examined whether food addiction and emotional eating are associated in undergraduate samples from the United States (n = 110) and South Korea (n = 141), and whether scores differ across key demographic subgroups within each country. Using a cross-sectional design, food addiction was assessed with the Yale Food Addiction Scale 2.0 (YFAS 2.0), and emotional eating was assessed with the Emotional Eating Scale-II (EES-II). Consistent with the study's central hypothesis, food addiction and emotional eating were strongly and positively correlated in both samples (South Korea r = 0.74; United States r = 0.53; both p < 0.001), and this association was significantly stronger in the South Korean sample (Fisher's z = 2.82, p = 0.005). In a hierarchical regression, emotional eating remained a robust predictor of food addiction symptoms after adjusting for country, age, gender, and sexual orientation (DeltaR (2) = 0.25, p < 0.001). Additionally, cisgender women reported higher emotional eating than cisgender men overall (p = 0.007), while gender differences in food addiction symptoms were not statistically significant (p = 0.069). Overall, these findings indicate pronounced cross-cultural differences in both food addiction symptoms and emotional eating, suggesting that sociocultural factors may shape how these eating-related behaviors are expressed, highlighting the importance of culturally informed strategies to address emotional regulation in increasingly obesogenic food environments worldwide. CI - Copyright (c) 2026 Mahoney, Sugarman, Hough, Szabo and Avena. FAU - Mahoney, Aidan AU - Mahoney A AD - Department of Psychology, Princeton University, Princeton, NJ, United States. AD - Interdisciplinary Affective Science Lab, Department of Psychology, Northeastern University, Boston, MA, United States. FAU - Sugarman, Susan AU - Sugarman S AD - Department of Psychology, Princeton University, Princeton, NJ, United States. FAU - Hough, Kaylee AU - Hough K AD - Department of Neuroscience, Ichan School of Medicine at Mount Sinai, New York, NY, United States. FAU - Szabo, Attila AU - Szabo A AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, Gyor, Hungary. FAU - Avena, Nicole AU - Avena N AD - Department of Psychology, Princeton University, Princeton, NJ, United States. AD - Department of Neuroscience, Ichan School of Medicine at Mount Sinai, New York, NY, United States. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Republic of Korea/epidemiology MH - *Emotional Eating/psychology MH - United States/epidemiology MH - *Food Addiction/psychology/epidemiology/ethnology MH - Female MH - *Students/psychology/statistics & numerical data MH - Male MH - Cross-Sectional Studies MH - *Cross-Cultural Comparison MH - Universities MH - Young Adult MH - Adult MH - Adolescent PMC - PMC13597360 OTO - NOTNLM OT - South Korea OT - cross-cultural comparison OT - emotional eating OT - food addiction OT - ultra-processed foods OT - undergraduate students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author NA declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/24 13:06 MHDA- 2026/09/24 13:07 PMCR- 2026/09/09 CRDT- 2026/09/24 08:30 PHST- 2026/05/25 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/24 13:07 [medline] PHST- 2026/09/24 13:06 [pubmed] PHST- 2026/09/24 08:30 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1890961 [doi] PST - epublish SO - Front Public Health. 2026 Sep 9;14:1890961. doi: 10.3389/fpubh.2026.1890961. eCollection 2026. PMID- 42780016 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260925 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - From motivation to movement: autonomous motivation and physical activity levels among students in the Global Health Program. PG - 1910169 LID - 10.3389/fpsyg.2026.1910169 [doi] LID - 1910169 AB - Little is known about how motivation relates to physical activity within large-scale school-based programs and whether this association varies according to contextual factors such as perceived school leader support, peer affiliation, or duration of program participation. This study examined the association between motivation for physical activity and physical activity levels among students participating in the Global Health Program (GHP) and tested whether this association was moderated by these contextual factors. Cross-sectional data were drawn from the Autumn 2024 baseline evaluation of the GHP, a school-based program implemented across 48 public schools in Quebec, Canada. A total of 664 students completed an online questionnaire, with participants represented across 22 schools. Among students with valid age data, the mean age was 14.05 years (SD = 1.80), and 58% were boys. Motivation was assessed using the Behavioural Regulation in Exercise Questionnaire-2, and physical activity was assessed using the PAQ-C or PAQ-A according to school level. Linear mixed-effects models with a random intercept for school were used to examine associations between motivation and physical activity, adjusting for age, sex, and mother's education. Moderation analyses tested interactions between the Relative Autonomy Index (RAI) and perceived school leader support, peer affiliation, and years of participation. A higher RAI was associated with a higher physical activity score in the adjusted model ( beta; = 0.02, 95% CI [0.01, 0.03], p < 0.001). Identified regulation ( beta; = 0.30, 95% CI [0.24, 0.36], p < 0.001) and intrinsic regulation ( beta; = 0.28, 95% CI [0.22, 0.35], p < 0.001) showed the strongest positive associations with physical activity. Introjected regulation was also positively associated with physical activity ( beta; = 0.12, 95% CI [0.08, 0.17], p < 0.001), whereas amotivation and external regulation were not statistically significant. Perceived school leader support and peer affiliation did not significantly moderate the association between the RAI and physical activity. However, years of participation significantly moderated this association (interaction beta; = 0.004, 95% CI [0.001, 0.008], p = 0.022), with a stronger positive association among students reporting longer participation in the GHP. Autonomous motivation was positively associated with physical activity among students participating in the GHP, particularly identified and intrinsic regulation. These findings support the relevance of Self-Determination Theory for understanding physical activity in school-based programs, while longitudinal research is needed to clarify the direction of the observed associations and the role of continued program participation. CI - Copyright (c) 2026 Ale, Belisle, Dore, Carbonneau, Barnett, Girard and Guimaraes. FAU - Ale, O J A AU - Ale OJA AD - Department of Physical Activity Sciences, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC, Canada. FAU - Belisle, J AU - Belisle J AD - Department of Physical Activity Sciences, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC, Canada. FAU - Dore, I AU - Dore I AD - School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada. AD - School of Public Health, Universite de Montreal, Montreal, QC, Canada. AD - University of Montreal Hospital Research Centre, Montreal, QC, Canada. FAU - Carbonneau, N AU - Carbonneau N AD - Department of Psychology, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC, Canada. FAU - Barnett, T AU - Barnett T AD - Department of Family Medicine, McGill University, Montreal, QC, Canada. AD - CHU Sainte-Justine Azrieli Research Centre, Montreal, QC, Canada. FAU - Girard, S AU - Girard S AD - Department of Physical Activity Sciences, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC, Canada. FAU - Guimaraes, R F AU - Guimaraes RF AD - Department of Physical Activity Sciences, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC, Canada. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13597243 OTO - NOTNLM OT - adolescents OT - autonomous motivation OT - motivational climate OT - peer affiliation OT - physical activity OT - school leaders OT - school-based intervention OT - self-determination theory COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 13:06 MHDA- 2026/09/24 13:07 PMCR- 2026/09/09 CRDT- 2026/09/24 07:16 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/24 13:07 [medline] PHST- 2026/09/24 13:06 [pubmed] PHST- 2026/09/24 07:16 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1910169 [doi] PST - epublish SO - Front Psychol. 2026 Sep 9;17:1910169. doi: 10.3389/fpsyg.2026.1910169. eCollection 2026. PMID- 42779848 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260930 IS - 2587-1250 (Electronic) IS - 2587-0823 (Print) IS - 2587-1250 (Linking) VI - 72 IP - 3 DP - 2026 Sep 24 TI - Physical activity and exercise in pediatric oncology: conceptual distinctions and clinical implications. PG - 275-282 LID - 10.4274/tftrd.2026.18471 [doi] AB - Survival in childhood cancers has markedly improved, yet many children experience treatment-related difficulties such as persistent fatigue, muscle weakness, reduced endurance, and impaired quality of life. As interest in non-pharmacological approaches grows, movement-based strategies, ranging from general physical activity to structured exercise, have become increasingly prominent in pediatric oncology care. This review aims to clarify the conceptual and practical differences between physical activity and structured exercise, and to summarize current evidence on movement-based interventions used during active treatment and survivorship in children and adolescents with cancer. Drawing on quantitative and qualitative studies published between 2000 and 2025, it shows that priorities shift across treatment phases: safety and feasibility are emphasized during active therapy, whereas long-term health and functional recovery gain importance in survivorship. The findings highlight the need for clearer terminology, coordinated multidisciplinary practice, meaningful family involvement, and consistent outcome measures with longer-term follow-up in future research. CI - (c)Copyright 2026 The Author(s). Published by Galenos Publishing House on behalf of the Turkish Society of Physical Medicine and Rehabilitation. FAU - Aydin, Ayse Resa AU - Aydin AR AUID- ORCID: 0000-0002-8496-7424 AD - Department of Physical Medicine and Rehabilitation, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkiye. FAU - Berktas, Yagmur AU - Berktas Y AUID- ORCID: 0000-0002-2221-3029 AD - Department of Supportive Treatment and Care in Cancer Patients, Istanbul University Institute of Health Sciences, Istanbul, Turkiye. LA - eng PT - Journal Article PL - Turkey TA - Turk J Phys Med Rehabil JT - Turkish journal of physical medicine and rehabilitation JID - 101719024 PMC - PMC13617965 OTO - NOTNLM OT - Pediatric oncology OT - childhood cancer OT - exercise OT - physical activity OT - rehabilitation OT - survivorship COIS- Ayse Resa Aydin, MD, is a member of the Scientific Advisory Board of the Turkish Journal of Physical Medicine and Rehabilitation. She was not involved in the peer-review process of this article and had no access to any information regarding its evaluation. The other author has no conflicts of interest to declare. EDAT- 2026/09/24 13:06 MHDA- 2026/09/24 13:07 PMCR- 2026/09/24 CRDT- 2026/09/24 06:24 PHST- 2026/09/24 13:07 [medline] PHST- 2026/09/24 13:06 [pubmed] PHST- 2026/09/24 06:24 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - 10.4274/tftrd.2026.18471 [doi] PST - ppublish SO - Turk J Phys Med Rehabil. 2026 Sep 24;72(3):275-282. doi: 10.4274/tftrd.2026.18471. PMID- 42779038 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260929 IS - 1547-1896 (Print) IS - 0893-7400 (Linking) VI - 39 IP - 10 DP - 2026 Oct 1 TI - Diagnosis and management of ankyloglossia in infants and children. PG - 32-36 LID - 10.1097/01.JAA.0000000000000420 [doi] AB - The diagnosis and management of ankyloglossia, commonly referred to as tongue-tie, has become a controversial topic spanning multiple subspecialties within pediatrics, dentistry, and rehabilitation medicine. Changing perspectives on clinical significance, increased awareness of breastfeeding challenges, and a stronger emphasis on a multidisciplinary approach have contributed to a dramatic rise in both diagnosis and intervention in this condition. Between 1997 and 2012, inpatient diagnoses of ankyloglossia in the United States increased nearly 10-fold, from 3,934 to 32,837 cases, with a similar increase in lingual frenotomy procedures, from 1,279 to 12,406. Providers may encounter tongue-tie in diverse settings, ranging from the newborn nursery to outpatient pediatric primary care to otolaryngology clinics. In the absence of a validated standalone threshold for surgical intervention, clinical decision-making can be challenging. This article provides clinically relevant, evidence-based recommendations to guide the diagnosis and management of ankyloglossia. Current guidance emphasizes direct assessment of the breastfeeding dyad, skilled lactation support, close monitoring of milk transfer and growth, and treatment of competing causes before frenotomy is considered. CI - Copyright (c) 2026 American Academy of Physician Associates. FAU - Fridman, Mark A AU - Fridman MA AD - Mark A. Fridman practices pediatric otolaryngology at Joe DiMaggio Children's Hospital in Hollywood, FL. The author has disclosed no potential conflicts of interest, financial or otherwise. LA - eng PT - Journal Article PT - Review DEP - 20260924 PL - United States TA - JAAPA JT - JAAPA : official journal of the American Academy of Physician Assistants JID - 9513102 SB - IM MH - Humans MH - *Ankyloglossia/diagnosis/therapy/surgery MH - Breast Feeding MH - Infant MH - Oral Frenectomy MH - Infant, Newborn MH - Child MH - Lingual Frenum/abnormalities/surgery MH - Female MH - Child, Preschool MH - Practice Guidelines as Topic OTO - NOTNLM OT - ankyloglossia OT - breastfeeding OT - multidisciplinary OT - otolaryngology OT - pediatrics OT - tongue-tie EDAT- 2026/09/24 05:37 MHDA- 2026/09/24 05:38 CRDT- 2026/09/24 01:14 PHST- 2026/09/24 05:38 [medline] PHST- 2026/09/24 05:37 [pubmed] PHST- 2026/09/24 01:14 [entrez] AID - 01720610-202610000-00004 [pii] AID - 10.1097/01.JAA.0000000000000420 [doi] PST - ppublish SO - JAAPA. 2026 Oct 1;39(10):32-36. doi: 10.1097/01.JAA.0000000000000420. Epub 2026 Sep 24. PMID- 42778566 OWN - NLM STAT- Publisher LR - 20260923 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) DP - 2026 Sep 23 TI - Metabolic dysfunction-associated steatotic liver disease-a review of the cardiometabolic perspectives and treatments in children. LID - 10.1038/s41366-026-02101-7 [doi] AB - The rising prevalence of childhood obesity is closely linked to the early onset of comorbid conditions, notably metabolic dysfunction-associated steatotic liver disease (MASLD), a hepatic manifestation of metabolic syndrome characterized by hepatic steatosis in the absence of significant alcohol intake. The pathophysiology of MASLD includes complex interactions among various factors such as hormonal, genetic, lifestyle and nutritional, and environmental dynamics. Emerging evidence indicates that MASLD is independently associated with a higher risk of cardiovascular disease (CVD), irrespective of traditional CV-risk factors such as hypertension, dyslipidemia, and diabetes mellitus. A comprehensive, multipronged approach is central to the detection, monitoring, and management of MASLD and associated adverse cardiovascular outcomes in children. Currently, there are no approved medications or other specific therapies for pediatric MASLD. While early stages of the disease are potentially reversible through lifestyle modifications, including diet/nutrition and physical activity, these strategies are often difficult to implement and sustain over time. Early detection of progression of MASLD to more severe conditions is hampered by the lack of reliable noninvasive methods of risk assessment tools. The objective of this review is to (1) succinctly summarize the relationship between MASLD and CVD risk in children and (2) discuss advances in MASLD management and treatment in children. We believe that this article will stimulate new avenues for research into MASLD and its broader cardiometabolic implications in pediatric populations. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - McGoogan, Katherine AU - McGoogan K AD - Division of Gastroenterology, Nemours Children's Health, Jacksonville, FL, USA. FAU - Hegde, Vijay AU - Hegde V AUID- ORCID: 0000-0003-4160-2764 AD - Department of Nutritional Sciences, Texas Tech University, Lubbock, TX, USA. FAU - Wilburn, Justin AU - Wilburn J AD - Division of Research, Nemours Children's Health, Jacksonville, FL, USA. FAU - Cooper, Felicia AU - Cooper F AUID- ORCID: 0000-0002-8554-3252 AD - Division of Endocrinology, Nemours Children's Health, Orlando, FL, USA. FAU - Gurnurkar, Shilpa AU - Gurnurkar S AD - Division of Endocrinology, Nemours Children's Health, Orlando, FL, USA. FAU - Prado, Wagner L AU - Prado WL AD - Department of Kinesiology, California State University, San Bernardino, CA, USA. FAU - Balagopal, P Babu AU - Balagopal PB AUID- ORCID: 0000-0001-6940-0772 AD - Department of Nutritional Sciences, Texas Tech University, Lubbock, TX, USA. babubalagopal@gmail.com. AD - Department of Pediatrics, Mayo Clinic College of Medicine, Rochester, MN, USA. babubalagopal@gmail.com. LA - eng PT - Journal Article PT - Review DEP - 20260923 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/09/24 05:37 MHDA- 2026/09/24 05:37 CRDT- 2026/09/23 23:19 PHST- 2025/08/22 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/02/23 00:00 [revised] PHST- 2026/09/24 05:37 [medline] PHST- 2026/09/24 05:37 [pubmed] PHST- 2026/09/23 23:19 [entrez] AID - 10.1038/s41366-026-02101-7 [pii] AID - 10.1038/s41366-026-02101-7 [doi] PST - aheadofprint SO - Int J Obes (Lond). 2026 Sep 23. doi: 10.1038/s41366-026-02101-7. PMID- 42777493 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261022 IS - 1872-6283 (Electronic) IS - 0379-0738 (Linking) VI - 389 DP - 2026 Dec TI - A novel four-teeth model for dental age estimation: Reliability, validity, and comparative accuracy with a seven-teeth approach. PG - 113142 LID - S0379-0738(26)00330-0 [pii] LID - 10.1016/j.forsciint.2026.113142 [doi] AB - Dental age estimation plays a critical role in forensic identification and legal age determination, particularly in children and adolescents. Although multi-tooth regression models demonstrate high predictive accuracy, their application may be restricted in situations involving incomplete dentition or suboptimal radiographic visualization. The present study aimed to develop and validate a simplified four-teeth model for dental age estimation and to compare its performance with established seven-teeth models. A cross-sectional study was conducted using 2000 panoramic radiographs of Indian children aged 5-16 yrs. Dental maturity was assessed using the normalized open apices method. A regression equation based on four mandibular posterior teeth (34, 35, 36, 37) was derived using stepwise multiple linear regression and validated on an test dataset (n = 500). Model performance was evaluated using coefficient of determination (R(2)), Root Mean Square Error (RMSE), and Mean Absolute Error (MAE), and compared with Prabhu's population-specific and Cameriere's seven-teeth models. The four-teeth model demonstrated good predictive ability (R(2) = 69.6%, p < 0.0001), with an overall RMSE of 1.15 yrs and MAE of 0.95 yrs. The highest accuracy was observed in the 9-13 yrs age group (RMSE = 0.98 yrs), where performance was comparable to the seven-teeth models. Prediction error increased in the 13-16-yrs group (RMSE = 1.50 yrs), reflecting reduced discriminatory information following completion of root development. The model may therefore be useful as a simplified adjunct for dental age estimation primarily during the 5-13-yrs developmental period, in cases of incomplete dentition or compromised radiographic quality while external validation is required before broader forensic application. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Prabhu, Rachana AU - Prabhu R AD - Department of Oral Medicine & Radiology, Yenepoya Dental College, Yenepoya (Deemed to be University), India. Electronic address: rachanaprabhu@yenepoya.edu.in. FAU - Yashaswini, K AU - Yashaswini K AD - Department of Biostatistics, Nitte Institute of Allied Health Sciences, K.S.Hegde Medical Academy, Nitte (Deemed to be University), India. FAU - Shenoy, Prashanth AU - Shenoy P AD - Department of Oral Medicine & Radiology, Yenepoya Dental College, Yenepoya (Deemed to be University), India. FAU - Prabhu, Vishnudas AU - Prabhu V AD - Department of Oral & Maxillofacial Pathology, Yenepoya Dental College, Yenepoya (Deemed to be University), India. FAU - Chatra, Laxmikanth AU - Chatra L AD - Department of Oral Medicine & Radiology, Yenepoya Dental College, Yenepoya (Deemed to be University), India. LA - eng PT - Comparative Study PT - Journal Article PT - Validation Study DEP - 20260918 PL - Ireland TA - Forensic Sci Int JT - Forensic science international JID - 7902034 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Child MH - Radiography, Panoramic MH - Adolescent MH - Child, Preschool MH - Reproducibility of Results MH - Forensic Dentistry/methods MH - Cross-Sectional Studies MH - Linear Models MH - Male MH - Female MH - Tooth Apex/diagnostic imaging/growth & development OTO - NOTNLM OT - Dental age estimation OT - Forensic odontology OT - Four teeth model OT - Open apices OT - Regression analysis COIS- Declaration of Competing Interest declare that there is no conflict of interest in submission of the same for publication in your esteemed journal. EDAT- 2026/09/23 23:56 MHDA- 2026/10/22 23:28 CRDT- 2026/09/23 18:07 PHST- 2026/04/24 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/22 23:28 [medline] PHST- 2026/09/23 23:56 [pubmed] PHST- 2026/09/23 18:07 [entrez] AID - S0379-0738(26)00330-0 [pii] AID - 10.1016/j.forsciint.2026.113142 [doi] PST - ppublish SO - Forensic Sci Int. 2026 Dec;389:113142. doi: 10.1016/j.forsciint.2026.113142. Epub 2026 Sep 18. PMID- 42777468 OWN - NLM STAT- Publisher LR - 20260923 IS - 1872-7654 (Electronic) IS - 0301-2115 (Linking) VI - 327 DP - 2026 Sep 19 TI - Construction and verification of a prediction model for gestational diabetes mellitus complicated with gestational hypertension based on a specialized disease research database. PG - 115449 LID - S0301-2115(26)00517-8 [pii] LID - 10.1016/j.ejogrb.2026.115449 [doi] AB - OBJECTIVE: To construct and validate a model for predicting the risk of gestational hypertension disorder (HDP) in pregnant women with gestational diabetes mellitus (GDM) and to explore the nonlinear association between key metabolic indicators and the risk of HDP. METHOD: This study was a multicenter retrospective cohort study. Data were derived from the GDM-specific databases of multiple collaborating hospitals and included singleton pregnant women with GDM from May 29, 2018 to October 30, 2025. A total of 1,500 pregnant women were included in the analysis, of which 123 (8.2%) developed HDP. Using Boruta algorithm for feature screening, the optimal breakpoint determined based on restricted cubic spline (RCS) is used to convert continuous variables into binary variables, and a multivariable logistic regression is used to construct a prediction model; Apply RCS and segmented regression to analyze the nonlinear effects and thresholds of key continuous variables. Internal validation was conducted using Bootstrap resampling, and the clinical net benefit of the model was evaluated using decision curve analysis (DCA). RESULTS: The final prediction model included six variables: pre pregnancy BMI >/= 25 kg/m (2) (OR = 1.92, 95% CI 1.28-2.87), assisted reproductive conception (OR = 1.80, 95% CI 1.07-3.04), history of adverse pregnancy and childbirth (OR = 1.54, 95% CI 0.97-2.47), HOMA-IR /= 2.867 mmol/L (OR = 1.81, 95% CI 0.91-3.59), and age >/= 35 years (OR = 1.32, 95% CI 0.89-1.94). There is a significant non-linear correlation between HOMA-IR and triglyceride levels in early pregnancy and HDP risk, with thresholds of 2.600 and 2.867 mmol/L, respectively. When the threshold is below, the risk increases sharply with the increase of indicators. After internal validation, the final model had a corrected C-index of 0.644 (AUC = 0.665), with acceptable calibration accuracy. Decision curve analysis shows that when the decision threshold is between 2% and 18%, applying the model to guide clinical intervention can bring net benefits. CONCLUSION: We constructed a moderately‑performing HDP risk‑prediction model for GDM‑complicating pregnancies using accessible clinical variables for auxiliary risk stratification, with HOMA‑IR and TG exploratory thresholds needing prospective validation before clinical use. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Gao, Lan AU - Gao L AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Wang, Fei AU - Wang F AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Ji, Qun AU - Ji Q AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Chen, ChunLan AU - Chen C AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Lin, CaiQiong AU - Lin C AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Lu, Min AU - Lu M AD - Department of Obstetrics and Gynecology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Chen, KaiNing AU - Chen K AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Liu, HaiWei AU - Liu H AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. Electronic address: hndxlhw@126.com. LA - eng PT - Journal Article DEP - 20260919 PL - Ireland TA - Eur J Obstet Gynecol Reprod Biol JT - European journal of obstetrics, gynecology, and reproductive biology JID - 0375672 SB - IM OTO - NOTNLM OT - Decision Curve analysis OT - Gestational diabetes mellitus OT - Hypertensive disorders in pregnancy OT - Nomogram OT - Predictive models OT - Threshold effect COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/23 23:56 MHDA- 2026/09/23 23:56 CRDT- 2026/09/23 18:06 PHST- 2025/12/24 00:00 [received] PHST- 2026/08/25 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/09/23 23:56 [medline] PHST- 2026/09/23 23:56 [pubmed] PHST- 2026/09/23 18:06 [entrez] AID - S0301-2115(26)00517-8 [pii] AID - 10.1016/j.ejogrb.2026.115449 [doi] PST - aheadofprint SO - Eur J Obstet Gynecol Reprod Biol. 2026 Sep 19;327:115449. doi: 10.1016/j.ejogrb.2026.115449. PMID- 42777335 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 2352-3964 (Electronic) IS - 2352-3964 (Linking) VI - 132 DP - 2026 Oct TI - Metabolomic profiling of ultra-processed food consumption and cardiovascular risk in Spanish preschool children: a cross-sectional study. PG - 106488 LID - S2352-3964(26)00372-5 [pii] LID - 10.1016/j.ebiom.2026.106488 [doi] LID - 106488 AB - BACKGROUND: Ultra-processed food (UPF) consumption has increased substantially among children worldwide and has been associated with early cardiovascular alterations. We aimed to identify plasma metabolomic profiles associated with UPF consumption in children aged 3-6 years and to assess their association with cardiovascular risk factors. METHODS: This cross-sectional analysis used baseline data from the Childhood Obesity Risk Assessment Longitudinal Study (CORALS), with children recruited between March 2019 and June 2022 through primary schools and health-care centres in seven Spanish cities. 1148 children were included (mean age 5.0 years [SD 1.1]; 50.6% girls) after exclusions due to medical conditions and incomplete or implausible dietary or metabolomic data. Energy-adjusted UPF intake (g/d) was assessed using a validated food frequency questionnaire and categorised with NOVA classification. 249 metabolites were quantified by NMR-based metabolomics, and lipid-related and amino acid-related profiles/scores were derived. A composite cardiovascular risk score (CVRs) was constructed by summing sex-specific, age-adjusted z-scores for fat-mass index, HDL-and LDL-cholesterol, triglycerides, mean arterial pressure, and Homoeostatic Model Assessment for Insulin Resistance. FINDINGS: 19 metabolites were associated with UPF consumption after false discovery rate correction (FDR). A lipid-related score was positively associated with CVRs (beta = 0.511; 95% CI: 0.413-0.610; FDR <0.001) and the amino acid-related score was associated with a lower CVRs (beta = -0.494; 95% CI: -0.667 to -0.321; FDR <0.001). Discrimination of cardiovascular risk beyond covariates alone was higher after inclusion of metabolomic scores, particularly when both scores were considered jointly (DeltaAUC 0.092, 95% CI: 0.013-0.172; p = 0.020). INTERPRETATION: In Spanish pre-schoolers UPF-related metabolomic profiles were associated with different cardiovascular risk factors. These diet-related metabolomic scores capture biological correlates relevant to early cardiovascular health and align with early-life metabolic pattering, supporting future longitudinal studies and prevention strategies. FUNDING: CIBEROBN; Instituto de Salud Carlos III (ISCIII-FIS; EU ERDF/ESF); ISCIII PFIS. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Perez-Acosta, Josue A AU - Perez-Acosta JA AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Garcia-Gavilan, Jesus F AU - Garcia-Gavilan JF AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Margara-Escudero, Hernando J AU - Margara-Escudero HJ AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Aguilera, Concepcion M AU - Aguilera CM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology (INYTA) and Center of Biomedical Research (CIBM), University of Granada, Granada, 18071, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. FAU - Leis, Rosaura AU - Leis R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Unit of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Service, Hospital Clinico Universitario de Santiago, 15706, Santiago de Compostela, Spain; Pediatric Nutrition Research Group, Health Research Institute of Santiago de Compostela (IDIS). Unit of Investigation in Nutrition, Growth and Human Development of Galicia-USC, 15706, Santiago de Compostela, Spain. FAU - Gheorghita, Irina AU - Gheorghita I AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Universitat Rovira i Virgili, Pediatric Nutrition and Human Development Research Unit (PediNuR), Reus, Spain. FAU - Miguel-Berges, Maria L AU - Miguel-Berges ML AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, Facultad de Ciencias de la Salud e Instituto Agroalimentario de Aragon (IA2) University of Zaragoza, Zaragoza, Spain. FAU - Navas-Carretero, Santiago AU - Navas-Carretero S AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; University of Navarra, Center for Nutrition Research, 31008, Pamplona, Spain; Universidad de Navarra, Instituto de Nutricion y Salud, 31080, Pamplona, Spain; IdisNA, Navarra Institute for Health Research, Pamplona, Spain. FAU - Sorli, Jose V AU - Sorli JV AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain. FAU - Lazaro, Iolanda AU - Lazaro I AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Hospital del Mar Research Institute, Barcelona, Spain. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), RD21/0012/0008, Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0007), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Vazquez-Cobela, Rocio AU - Vazquez-Cobela R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Unit of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Service, Hospital Clinico Universitario de Santiago, 15706, Santiago de Compostela, Spain; Pediatric Nutrition Research Group, Health Research Institute of Santiago de Compostela (IDIS). Unit of Investigation in Nutrition, Growth and Human Development of Galicia-USC, 15706, Santiago de Compostela, Spain. FAU - Iglesias-Vazquez, Lucia AU - Iglesias-Vazquez L AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - De Miguel-Etayo, Pilar AU - De Miguel-Etayo P AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, Facultad de Ciencias de la Salud e Instituto Agroalimentario de Aragon (IA2) University of Zaragoza, Zaragoza, Spain; Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Vazquez-Bolea, Natalia AU - Vazquez-Bolea N AD - University of Navarra, Center for Nutrition Research, 31008, Pamplona, Spain; Universidad de Navarra, Instituto de Nutricion y Salud, 31080, Pamplona, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Picans-Leis, Rosaura AU - Picans-Leis R AD - Neonatology Service, RICORS-SAMID-CIBERER, University Clinical Hospital of Santiago de Compostela, Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Escribano, Joaquin AU - Escribano J AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Universitat Rovira i Virgili, Pediatric Nutrition and Human Development Research Unit (PediNuR), Reus, Spain; Hospital Universitari Sant Joan de Reus, Servicio de Pediatria, Reus, Spain. FAU - Moreno, Luis A AU - Moreno LA AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, Facultad de Ciencias de la Salud e Instituto Agroalimentario de Aragon (IA2) University of Zaragoza, Zaragoza, Spain; Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Torre-Aguilar, MJose de la AU - Torre-Aguilar M AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jordi.salas@urv.cat. FAU - Babio, Nancy AU - Babio N AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: nancy.babio@urv.cat. LA - eng PT - Journal Article DEP - 20260923 PL - Netherlands TA - EBioMedicine JT - EBioMedicine JID - 101647039 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Cardiovascular Diseases/epidemiology/etiology/metabolism MH - *Metabolomics/methods MH - Spain/epidemiology MH - Cross-Sectional Studies MH - Child, Preschool MH - Male MH - Child MH - *Metabolome MH - *Fast Foods/adverse effects MH - Biomarkers MH - Heart Disease Risk Factors MH - Risk Factors PMC - PMC13634276 OTO - NOTNLM OT - Cardiometabolic risk OT - Children OT - Metabolomics OT - Ultra-processed foods COIS- Declaration of interests JS-S reports non-financial support in the form of food products (virgin olive oil, almonds, and pistachios) provided by Patrimonio Comunal Olivarero, the Almond Board of California, and American Pistachio Growers, respectively, for pilot study participants. JS-S serves on the scientific advisory boards of the Danone Institute International and the International Nut and Dried Fruit Foundation on an unpaid basis. JS-S has received travel and accommodation support from the International Nut and Dried Fruit Foundation to attend scientific meetings and has participated as a member of the international advisory board of a research project on cashew nut supplementation in type 2 diabetes. Outside the submitted work, JS-S has received honoraria for lectures from the Danone Institute Spain and institutional grants or in-kind support from the International Nut and Dried Fruit Foundation. NVB reports an FPU grant from the Spanish Ministry of Science, Innovation and Universities (MCIU; FPU23/01950). All other authors declare no competing interests. EDAT- 2026/09/23 23:56 MHDA- 2026/10/14 23:31 PMCR- 2026/09/23 CRDT- 2026/09/23 18:02 PHST- 2026/02/23 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/14 23:31 [medline] PHST- 2026/09/23 23:56 [pubmed] PHST- 2026/09/23 18:02 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - S2352-3964(26)00372-5 [pii] AID - 106488 [pii] AID - 10.1016/j.ebiom.2026.106488 [doi] PST - ppublish SO - EBioMedicine. 2026 Oct;132:106488. doi: 10.1016/j.ebiom.2026.106488. Epub 2026 Sep 23. PMID- 42777198 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260923 IS - 2791-6421 (Electronic) IS - 0041-4301 (Linking) VI - 68 IP - 4 DP - 2026 Sep 11 TI - Esophageal atresia and nutritional outcomes: the influence of anastomotic stricture and gastroesophageal reflux. PG - 662-671 LID - 10.24953/turkjpediatr.2026.6347 [doi] AB - BACKGROUND: Esophageal atresia (EA) is a congenital malformation often associated with long-term gastrointestinal complications and impaired growth. This study aimed to evaluate anthropometric outcomes in children with EA, with particular attention to the impact of associated conditions such as anastomotic stricture and gastroesophageal reflux (GER). METHODS: We conducted a retrospective analysis of patients with type C EA who underwent primary anastomosis between 2005 and 2021. Anthropometric data were collected at four age intervals (<1 year, 1-4 years, 5-11 years, >11 years) and standardized using validated growth charts. Associations between anthropometric parameters and the presence of stricture or GER were analyzed. RESULTS: Fifty-seven patients met the inclusion criteria. Stricture and GER were identified in 32% and 30% of patients, respectively. Infants (<1 year) with stricture had significantly lower BMI Z-scores -2.5 +/- 0.7 than those without stricture (-1.1 +/- 1.1; p=0.0093), while those with GER had significantly lower weight Z-scores (-2.1 +/- 1.0) than those without GER (-1.2 +/- 1.1; p=0.0443). Although most patients showed improvement in anthropometric parameters with age, early growth impairment was consistently observed in association with these complications. CONCLUSIONS: Children with EA are at risk of impaired growth during early childhood, particularly when stricture or GER is present. Regular anthropometric monitoring and early nutritional intervention are crucial, especially within the first year of life. Long-term multidisciplinary follow-up is recommended to optimize developmental outcomes. FAU - Salcedo Arroyo, Paula AU - Salcedo Arroyo P AUID- ORCID: 0000-0003-2579-2094 AD - Department of Pediatrics, Hospital Consorci Sanitari de Terrassa, Terrassa, Spain. AD - Department of Pediatrics, Hospital Universitari Mutua de Terrassa, Terrassa, Spain. FAU - Bragagnini Rodriguez, Paolo AU - Bragagnini Rodriguez P AUID- ORCID: 0000-0002-3053-3436 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Fernandez Atuan, Rafael AU - Fernandez Atuan R AUID- ORCID: 0000-0002-3204-0483 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. AD - University of Zaragoza, Zaragoza, Spain. FAU - Garcia Romero, Ruth AU - Garcia Romero R AUID- ORCID: 0000-0002-3017-1340 AD - Department of Pediatric Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Vargova, Paulina AU - Vargova P AUID- ORCID: 0000-0002-0705-5309 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Ros Arnal, Ignacio AU - Ros Arnal I AUID- ORCID: 0000-0003-4163-8003 AD - Department of Pediatric Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Corona Bellostas, Carolina AU - Corona Bellostas C AUID- ORCID: 0000-0002-7368-1033 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. AD - University of Zaragoza, Zaragoza, Spain. LA - eng PT - Journal Article DEP - 20260911 PL - Turkey TA - Turk J Pediatr JT - The Turkish journal of pediatrics JID - 0417505 SB - IM MH - Humans MH - *Esophageal Atresia/surgery/complications MH - *Gastroesophageal Reflux/complications/etiology MH - Retrospective Studies MH - Female MH - Male MH - Infant MH - Child MH - Child, Preschool MH - *Esophageal Stenosis/etiology MH - Anastomosis, Surgical/adverse effects MH - *Postoperative Complications MH - *Nutritional Status OTO - NOTNLM OT - esophageal atresia OT - esophageal stricture OT - gastroesophageal reflux OT - growth OT - nutritional status EDAT- 2026/09/23 17:37 MHDA- 2026/09/23 23:56 CRDT- 2026/09/23 16:06 PHST- 2025/05/23 00:00 [received] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/23 23:56 [medline] PHST- 2026/09/23 17:37 [pubmed] PHST- 2026/09/23 16:06 [entrez] AID - 6347 [pii] AID - 10.24953/turkjpediatr.2026.6347 [doi] PST - epublish SO - Turk J Pediatr. 2026 Sep 11;68(4):662-671. doi: 10.24953/turkjpediatr.2026.6347. PMID- 42776987 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260925 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 9 DP - 2026 TI - Acceptability, feasibility, appropriateness, uptake and cost perceptions of family mid-upper arm circumference supported by two-way SMS in western Kenya. PG - e0358775 LID - 10.1371/journal.pone.0358775 [doi] LID - e0358775 AB - Early identification and treatment of acute malnutrition can decrease mortality and morbidity related to wasting or low weight-for-height. Teaching caregivers to measure mid-upper arm circumference (MUAC), an approach known as Family MUAC, may support early diagnosis of wasting. Family MUAC paired with mobile support from healthcare workers resulted in a 37% reduction in child wasting in the Mama Aweza trial in Kenya. This study examines the intervention's acceptability, feasibility, appropriateness, uptake, perceptions of cost savings, and factors influencing engagement with Family MUAC. This qualitative study involved eight focus group discussions with caregivers enrolled in the Mama Aweza trial and fourteen in-depth interviews with caregivers who participated in the intervention arm, Family MUAC supported by two-way short message service (SMS). Caregivers were purposively selected based on engagement level with the intervention. Eighteen program staff and healthcare workers from three facilities in western Kenya participated in in-depth interviews. The Theoretical Domains Framework informed design of data collection tools. Caregiver and healthcare worker perceptions of Family MUAC with two-way SMS centered on seven themes. The intervention was viewed as acceptable, cost-saving, appropriate, feasible, and empowering. Caregiver uptake was high, and integrating child growth monitoring with other health services may help enhance sustainability. Barriers to uptake included inconsistent MUAC measurements, limited social support, and issues with phone sharing. Refresher trainings could increase accuracy of MUAC measurements and improve engagement. Direct communication with healthcare workers via SMS built trust and strengthened patient-provider relationships. Caregivers also reported perceived cost savings, as SMS communication reduced unnecessary travel to health centers when children were not malnourished. This study supports Family MUAC with two-way SMS as a promising approach to empower caregivers and highlights their critical role in child health and nutrition interventions. Future interventions can focus on improving measurement accuracy and mitigating negative social influences on caregiver-led interventions. CI - Copyright: (c) 2026 Choo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Choo, Esther M AU - Choo EM AUID- ORCID: 0000-0001-6564-7962 AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. FAU - Lara-Arevalo, Jonathan AU - Lara-Arevalo J AUID- ORCID: 0000-0001-9588-7027 AD - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Achieng, Catherine AU - Achieng C AD - Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. FAU - Odhiambo, Merceline AU - Odhiambo M AD - Independent Consultant, Nairobi, Kenya. FAU - Okello, Maurine Anyango AU - Okello MA AD - Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. FAU - Masheti, Mary AU - Masheti M AD - Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. FAU - Tickell, Kirkby D AU - Tickell KD AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. FAU - Diakhate, Mame M AU - Diakhate MM AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. FAU - Singa, Benson O AU - Singa BO AD - Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. FAU - McGrath, Christine J AU - McGrath CJ AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. FAU - Means, Arianna Rubin AU - Means AR AUID- ORCID: 0000-0002-4087-7080 AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. LA - eng PT - Journal Article DEP - 20260923 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Kenya MH - *Arm/anatomy & histology MH - Female MH - Male MH - *Text Messaging MH - Caregivers/psychology MH - Feasibility Studies MH - Adult MH - Infant MH - Focus Groups MH - Child, Preschool MH - Health Personnel PMC - PMC13600513 COIS- The authors have declared that no competing interests exist. EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:37 PMCR- 2026/09/23 CRDT- 2026/09/23 13:44 PHST- 2025/12/17 00:00 [received] PHST- 2026/09/06 00:00 [accepted] PHST- 2026/09/23 17:37 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 13:44 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - PONE-D-25-63080 [pii] AID - 10.1371/journal.pone.0358775 [doi] PST - epublish SO - PLoS One. 2026 Sep 23;21(9):e0358775. doi: 10.1371/journal.pone.0358775. eCollection 2026. PMID- 42776291 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20261008 IS - 1534-312X (Electronic) IS - 1522-8037 (Linking) VI - 28 IP - 1 DP - 2026 Sep 23 TI - Small Intestinal Bacterial Overgrowth in the Pediatric Population: A Review of Pathophysiology, Diagnosis, and Management. LID - 32 [pii] LID - 10.1007/s11894-026-01059-w [doi] AB - PURPOSE OF REVIEW: Small intestinal bacterial overgrowth (SIBO) remains a significant diagnostic and therapeutic challenge in pediatric gastroenterology. This review summarizes the epidemiology, pathophysiology, diagnosis, and management of SIBO in children, with emphasis on recent advances in microbiome science, evolving diagnostic paradigms, and pediatric-specific clinical considerations. RECENT FINDINGS: SIBO is increasingly recognized across a broad range of pediatric conditions, including intestinal failure, motility disorders, disorders of gut-brain interaction, and systemic diseases associated with gastrointestinal dysmotility. Diagnosis remains challenging as currently available tests have important limitations and pediatric-specific diagnostic standards are lacking. Management requires a multifaceted approach that combines antimicrobial therapy, correction of underlying anatomic abnormalities or treatment of dysmotility, nutritional support, and emerging microbiome-directed strategies. Future research should focus on validating pediatric-specific diagnostic criteria, defining optimal treatment regimens, and advancing precision approaches to microbiome characterization and modulation. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Mody, Shaan AU - Mody S AUID- ORCID: 0009-0002-6989-7963 AD - Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA. FAU - Laxer, Alison AU - Laxer A AUID- ORCID: 0009-0001-9414-1706 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center/NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Gandhi, Jermie AU - Gandhi J AUID- ORCID: 0009-0008-6845-3395 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center/NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. jg4701@cumc.columbia.edu. LA - eng PT - Journal Article PT - Review DEP - 20260923 PL - United States TA - Curr Gastroenterol Rep JT - Current gastroenterology reports JID - 100888896 RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - Child MH - *Intestine, Small/microbiology/physiopathology MH - Anti-Bacterial Agents/therapeutic use MH - *Blind Loop Syndrome/diagnosis/therapy/physiopathology MH - Gastrointestinal Microbiome OTO - NOTNLM OT - Antibiotic therapy OT - Breath test OT - Dysbiosis OT - Dysmotility OT - Short bowel syndrome OT - Small intestinal bacterial overgrowth (SIBO) COIS- Declarations. The authors did not receive support from any organization for the submitted work. Human and animal rights: This article does not contain any studies with human or animal subjects performed by any of the authors. Competing interests: The authors declare no competing interests. EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:37 CRDT- 2026/09/23 11:16 PHST- 2026/07/29 00:00 [received] PHST- 2026/09/20 00:00 [accepted] PHST- 2026/09/23 17:37 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:16 [entrez] AID - 10.1007/s11894-026-01059-w [pii] AID - 10.1007/s11894-026-01059-w [doi] PST - epublish SO - Curr Gastroenterol Rep. 2026 Sep 23;28(1):32. doi: 10.1007/s11894-026-01059-w. PMID- 42776278 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20261001 IS - 1432-1335 (Electronic) IS - 0171-5216 (Print) IS - 0171-5216 (Linking) VI - 152 IP - 9 DP - 2026 Sep 22 TI - Sleep quality and disturbances in adolescents and young adults with cancer compared to a healthy comparison group: results of the AYA-LE study. LID - 10.1007/s00432-026-06627-1 [doi] LID - 185 AB - PURPOSE: Adolescents and young adults (AYAs) with cancer often exhibit riskier health behaviors, including poorer sleep patterns, compared to older individuals. Research on the relationship between cancer and sleep quality in AYA patients has yielded inconsistent results. This study investigates sleep quality in AYA patients compared to a healthy comparison group and examines associated sociodemographic, clinical, and psychosocial variables as well as physical activity. METHODS: The prospective observational study included 407 AYA patients aged 18-39 years at diagnosis and 372 healthy participants aged 18-45 years, with data collected from May-September 2019. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Validated questionnaires measured self-efficacy, social support, anxiety, depression, quality of life, lack of energy, and physical activity. Multiple regression analyses were employed to explore the variables associated with sleep quality. RESULTS: The mean age of the AYA patients was 34.8 years (75.2% women) and 32.3 years of the healthy participants (61.8% women). AYA patients demonstrated significantly poorer subjective sleep quality (d=0.31), lower sleep efficiency (d=0.15), more frequent sleep disturbances (d=0.23), greater use of sleep medication (d=0.25), and higher daytime dysfunction (d=0.29). Anxiety, depression (HADS), quality of life (EORTC), and unmet needs for support through lack of energy (SCNS) were significantly associated with PSQI (adjusted R(2)=0.35). CONCLUSION: These findings underscore the relevance of sleep disturbances in AYA patients and support greater attention to sleep disturbances in survivorship care. Routine assessment of sleep quality may help identify AYA patients who could benefit from further evaluation and appropriate support. CI - (c) 2026. The Author(s). FAU - Wieland, Carolin AU - Wieland C AUID- ORCID: 0009-0007-2507-5294 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Friedrich, Michael AU - Friedrich M AUID- ORCID: 0000-0002-0528-1564 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Sender, Annekathrin AU - Sender A AUID- ORCID: 0000-0002-5457-4021 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Leuteritz, Katja AU - Leuteritz K AUID- ORCID: 0000-0002-5942-0988 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Brock, Hannah AU - Brock H AUID- ORCID: 0000-0002-9905-9488 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Geue, Kristina AU - Geue K AUID- ORCID: 0000-0001-6590-5650 AD - University Clinic for Psychosomatic Medicine and Psychotherapy, University Medical Center Magdeburg, Otto-von-Guericke Universitat Magdeburg, Magdeburg, Germany. FAU - Mehnert-Theuerkauf, Anja AU - Mehnert-Theuerkauf A AUID- ORCID: 0000-0002-6872-9805 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Richter, Diana AU - Richter D AUID- ORCID: 0000-0003-3977-2801 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. diana.richter@medizin.uni-leipzig.de. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260922 PL - Germany TA - J Cancer Res Clin Oncol JT - Journal of cancer research and clinical oncology JID - 7902060 SB - IM MH - Humans MH - Female MH - Adult MH - Young Adult MH - Adolescent MH - *Neoplasms/complications/psychology/physiopathology MH - *Sleep Quality MH - Male MH - *Sleep Wake Disorders/etiology/epidemiology MH - Prospective Studies MH - Quality of Life MH - Surveys and Questionnaires MH - Middle Aged MH - Case-Control Studies MH - Depression PMC - PMC13601403 OTO - NOTNLM OT - AYA OT - Cancer OT - PSQI OT - Psycho-oncology OT - Sleep OT - Survivorship COIS- Declarations. Conflict of interest: The authors declare no conflict of interest. EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:37 PMCR- 2026/09/22 CRDT- 2026/09/23 11:14 PHST- 2026/08/11 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/23 17:37 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:14 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - 10.1007/s00432-026-06627-1 [pii] AID - 6627 [pii] AID - 10.1007/s00432-026-06627-1 [doi] PST - epublish SO - J Cancer Res Clin Oncol. 2026 Sep 22;152(9):185. doi: 10.1007/s00432-026-06627-1. PMID- 42776237 OWN - NLM STAT- Publisher LR - 20260923 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) DP - 2026 Sep 23 TI - The Fontan Choir: Singing for Single Ventricle Health and Wellbeing Feasibility Study. LID - 10.1007/s00246-026-04483-x [doi] AB - Children with Fontan circulation (FC) rely on passive blood flow to the lungs and require optimal lung function [1, 2]. Singing has been shown to increase exercise capacity, improve lung function and enhance quality of life (QoL) in adults and in rare studies of children with non-cardiac disease [7-9]. Singing as an intervention has not been studied in children with FC. A feasibility program of in-person and online singing and breathing instruction was developed and trialed by the Bienen School of Music and the Heart Center of the Ann & Robert H. Lurie Children's Hospital of Chicago. Pre- and post-intervention measures of exercise capacity, respiratory muscle strength, and QoL assessments were conducted before and after 8 weeks of singing instruction. This study provided 30 min of private voice instruction and 60 min of group instruction/week for eight weeks. In-person instruction was supported by an asynchronous on-line program of singing and breathing exercises performed independently several days per week between in-person sessions. The program was safe and feasible. 14 children aged 8-16 years completed the study with an 89% attendance rate and 27.5% homework completion rate. Post-intervention assessments demonstrated improvements in 3 breathing measures (single breath counting, sustained ah, and Twinkle Twinkle task) p < 0.005. Improvements occurred in patient self-report of depression (p < 0.05) and parent proxy reports of school function (p = 0.04), depression (p = 0.03) and anxiety (p = 0.02) and patient wellbeing p < 0.01. There was no improvement in spirometry or 6MWT. The program was well received by both children and parents. Our findings support the feasibility and acceptability of singing as an adjunct intervention for FC patients. Further investigation of these findings in a larger, longer trial is warranted. CI - (c) 2026. The Author(s). FAU - Ward, Kendra M AU - Ward KM AUID- ORCID: 0009-0009-0012-7750 AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. kward@luriechildrens.org. AD - Northwestern University Feinberg School of Medicine, Pediatrics, Chicago, IL, USA. kward@luriechildrens.org. FAU - Bartolome, Sarah J AU - Bartolome SJ AUID- ORCID: 0000-0003-1469-3883 AD - Northwestern University Henry and Leigh Bienen School of Music, Evanston, IL, USA. FAU - Steltzer, Michelle M AU - Steltzer MM AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. FAU - Snyder, Amanda AU - Snyder A AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. FAU - Gregoire, Stephanie J AU - Gregoire SJ AUID- ORCID: 0009-0007-3425-6724 AD - University of Illinois Chicago School of Theatre and Music, Music Education, Chicago, IL, USA. FAU - Vogel, Casey AU - Vogel C AUID- ORCID: 0009-0004-5328-1800 AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. FAU - McNulty, Devin C AU - McNulty DC AUID- ORCID: 0000-0002-9127-5688 AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. FAU - Gustafson, Nancy J AU - Gustafson NJ AD - Northwestern University Henry and Leigh Bienen School of Music, Evanston, IL, USA. FAU - Brancaccio, Theresa A AU - Brancaccio TA AD - Northwestern University Henry and Leigh Bienen School of Music, Evanston, IL, USA. FAU - Allen, Kiona Y AU - Allen KY AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. AD - Northwestern University Feinberg School of Medicine, Pediatrics, Chicago, IL, USA. FAU - Loomba, Rohit AU - Loomba R AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. AD - Northwestern University Feinberg School of Medicine, Pediatrics, Chicago, IL, USA. FAU - Miller, Jodi AU - Miller J AUID- ORCID: 0009-0005-9329-4400 AD - Johns Hopkins University School of Education, Baltimore, MD, USA. FAU - Pelech, Andrew AU - Pelech A AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. AD - Northwestern University Feinberg School of Medicine, Pediatrics, Chicago, IL, USA. LA - eng PT - Journal Article DEP - 20260923 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM OTO - NOTNLM OT - Fontan OT - Restrictive lung disease OT - Singing OT - Single ventricle COIS- Declarations. Competing Interests: The authors declare no competing interests. EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:36 CRDT- 2026/09/23 11:12 PHST- 2026/07/01 00:00 [received] PHST- 2026/09/05 00:00 [accepted] PHST- 2026/09/23 17:36 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:12 [entrez] AID - 10.1007/s00246-026-04483-x [pii] AID - 10.1007/s00246-026-04483-x [doi] PST - aheadofprint SO - Pediatr Cardiol. 2026 Sep 23. doi: 10.1007/s00246-026-04483-x. PMID- 42776174 OWN - NLM STAT- Publisher LR - 20260923 IS - 1558-9110 (Electronic) IS - 1058-0360 (Linking) DP - 2026 Sep 23 TI - The Management of Swallowing Disorders in Children With Spinal Muscular Atrophy Type 1: A Scoping Review. PG - 1-22 LID - 10.1044/2026_AJSLP-25-00460 [doi] AB - PURPOSE: Spinal muscular atrophy Type 1 (SMA1) is a rare autosomal recessive neuromuscular disorder with progressive muscle weakness and atrophy. Dysphagia is common among children with SMA1, and its complications are frequently documented. This scoping review aimed to describe the management of swallowing disorders in this population. METHOD: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, four electronic databases were searched (PubMed, Embase, CINAHL, and Cochrane Library) for studies on children with SMA1. We investigated the management of swallowing disorders in children with SMA1, including methods and protocols used to assess swallowing and feeding, and treatment option. The quality of included studies was assessed using the Joanna Briggs Institute checklists; two independent researchers conducted study selection and data extraction. RESULTS: Thirty-eight studies with a total of 1,784 SMA1 patients were included. Swallowing was evaluated using instrumental methods (flexible endoscopic evaluation of swallowing and videofluoroscopic swallowing study) and clinical assessments, with one validated protocol identified for pediatric SMA (Oral and Swallowing Abilities Tool). Delayed initiation of swallowing, oral impairment, pharyngeal residues, and aspiration were frequently reported. Percutaneous endoscopic gastrostomy was used in cases of severe dysphagia, malnutrition, and failure to thrive. Few studies reported information on compensatory strategies and rehabilitative treatments. CONCLUSION: Further research is needed to standardize swallowing assessment approaches and to evaluate the effectiveness of rehabilitative and compensatory interventions in children with SMA1. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.33746656. FAU - Rocca, Sara AU - Rocca S AUID- ORCID: 0000-0002-4144-7269 AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. FAU - Pizzi, Laura AU - Pizzi L AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. FAU - Pizzorni, Nicole AU - Pizzorni N AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. FAU - Gandolfi, Sofia AU - Gandolfi S AD - Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. FAU - Masson, Riccardo AU - Masson R AD - Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. FAU - Schindler, Antonio AU - Schindler A AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. AD - Phoniatric and Speech and Language Pathology Unit, V. Buzzi Children Hospital, ASST Fatebenefratelli Sacco, Milan, Italy. LA - eng PT - Journal Article DEP - 20260923 PL - United States TA - Am J Speech Lang Pathol JT - American journal of speech-language pathology JID - 9114726 SB - IM EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:36 CRDT- 2026/09/23 11:07 PHST- 2026/09/23 17:36 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:07 [entrez] AID - 10.1044/2026_AJSLP-25-00460 [doi] PST - aheadofprint SO - Am J Speech Lang Pathol. 2026 Sep 23:1-22. doi: 10.1044/2026_AJSLP-25-00460. PMID- 42775974 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260928 IS - 2164-2591 (Electronic) IS - 2164-2591 (Linking) VI - 15 IP - 9 DP - 2026 Sep 1 TI - Description and Evaluation of a Visual Acuity Assessment Paradigm Based on Spatial Frequency-Modulated Form Discrimination. PG - 15 LID - 10.1167/tvst.15.9.15 [doi] LID - 15 AB - PURPOSE: To describe and evaluate a visual acuity assessment paradigm based on spatial frequency-modulated form discrimination for induced and disease-driven vision loss. METHODS: The Patterned-Optotype-in-Noise Task (POINT) consisted of arrow-shaped random noise patterns, each with a 1/f2 amplitude spectrum overlaid on a low-pass filtered background. Stimulus difficulty varied logarithmically across 22 levels by adjusting the background cutoff spatial frequency, relative to foreground. Monocular acuity was measured for POINT stimuli and letter optotypes in 20 adults (21-46 years) with 0-4D of induced blur and in 50 patients (9-77 years) with vision impairment from ocular pathologies/uncorrected refractive error. RESULTS: The POINT demonstrated systematic loss in visual acuity with induced optical blur and eye pathologies, like the standard letter acuity test (P < 0.001). The losses with induced blur in the POINT followed standard Fourier optics predictions of spatial-frequency discrimination between the background and foreground pattern. The test-retest repeatability of POINT was also comparable to letter acuity testing (mean difference +/- 95% limits of agreement: +0.04 units +/- 0.2 units), but with limited agreement in the acuity measures obtained between the two tests. CONCLUSIONS: The POINT is a reliable technique for estimating visual acuity with induced and disease-driven vision loss. However, caution should be exercised when directly comparing these outcomes to standard letter acuity tests owing to fundamental differences in stimulus construction and task requirements. TRANSLATIONAL RELEVANCE: The POINT offers a physiologically and theoretically grounded complement to standard assessment of visual acuity in clinical, research and public eye health settings. FAU - Lansey, Jonathan AU - Lansey J AD - REACT Neuro, Inc., Cambridge, MA, USA. FAU - Sirivella, Indrani AU - Sirivella I AD - Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India. AD - Centre for Technology Innovation, L V Prasad Eye Institute, Hyderabad, India. FAU - Negi, Rahul AU - Negi R AD - Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India. AD - Centre for Technology Innovation, L V Prasad Eye Institute, Hyderabad, India. FAU - Patel, Shaun R AU - Patel SR AD - REACT Neuro, Inc., Cambridge, MA, USA. FAU - Bharadwaj, Shrikant R AU - Bharadwaj SR AD - Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India. AD - Centre for Technology Innovation, L V Prasad Eye Institute, Hyderabad, India. AD - Brien Holden Institute of Optometry and Vision Sciences, L V Prasad Eye Institute, Hyderabad, India. LA - eng PT - Journal Article PL - United States TA - Transl Vis Sci Technol JT - Translational vision science & technology JID - 101595919 SB - IM MH - Humans MH - *Visual Acuity/physiology MH - Middle Aged MH - *Vision Tests/methods MH - Adult MH - Female MH - Adolescent MH - Aged MH - Male MH - Child MH - Young Adult MH - Reproducibility of Results MH - *Form Perception/physiology MH - *Discrimination, Psychological/physiology MH - *Vision Disorders/physiopathology/diagnosis MH - Photic Stimulation/methods PMC - PMC13615559 COIS- Disclosure: J. Lansey, ReactNeuro (E); I. Sirivella, None; R. Negi, None; S.R. Patel, ReactNeuro (E); S.R. Bharadwaj, None EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/23 CRDT- 2026/09/23 09:33 PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 09:33 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 2818601 [pii] AID - TVST-26-9779 [pii] AID - 10.1167/tvst.15.9.15 [doi] PST - ppublish SO - Transl Vis Sci Technol. 2026 Sep 1;15(9):15. doi: 10.1167/tvst.15.9.15. PMID- 42775715 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260925 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Animal- and Plant-Source Protein-Rich Foods Differ in Their Association With Maternal Micronutrient Status and Breast Milk Composition During Lactation. PG - e70253 LID - 10.1111/mcn.70253 [doi] LID - e70253 AB - Micronutrient deficiencies in lactating women remain widespread and under-addressed, compromising maternal health and breast milk quality. Although dietary guidelines promote protein-rich foods, most do not distinguish between animal and plant sources within this food group, despite differences in nutrient profiles and bioavailability. This study examined associations between intake of animal-source and plant-source foods within the protein-rich food group and maternal nutritional biomarkers in blood and breast milk. Nutrient contributions from each source and intake patterns across sociodemographic groups were also assessed. Data were drawn from 220 mother-infant pairs in urban and rural West Java, Indonesia. Maternal dietary intake was assessed over 3 non-consecutive days using a combination of weighed food records and recall. At 5 months postpartum, maternal BMI, blood, and breast milk samples were collected to assess zinc, iron, vitamin A, and B12 status. Associations between dietary intake and maternal biomarkers were analysed using multiple linear regression, adjusting for relevant covariates. Total protein-rich food intake was not significantly associated with maternal biomarkers. However, higher intake of animal-source protein-rich foods was positively associated with serum B12 and zinc, while higher intake of plant-source protein-rich foods was inversely associated with breast milk vitamin A. Macronutrients, particularly protein and fat, from animal-based foods were more strongly associated with maternal micronutrient biomarkers than micronutrient intake alone. Protein-rich food intake did not vary across sociodemographic groups, indicating feasibility for broad-based interventions. These findings support a shift in dietary guidance for lactating women, from focusing solely on total quantity of protein-rich foods to recognising nutritionally meaningful differences between animal-source and plant-source foods. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Rahmannia, Sofa AU - Rahmannia S AUID- ORCID: 0000-0003-2988-1334 AD - School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia. AD - Faculty of Medicine, Universitas Pasundan, Bandung, West Java, Indonesia. FAU - Arena, Gina AU - Arena G AUID- ORCID: 0000-0002-6956-3472 AD - Medical School, The University of Western Australia, Nedlands, Western Australia, Australia. AD - The Kids Research Institute, Nedlands, Western Australia, Australia. FAU - Murray, Kevin AU - Murray K AUID- ORCID: 0000-0002-8856-6046 AD - School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia. FAU - Diana, Aly AU - Diana A AUID- ORCID: 0000-0002-9394-5235 AD - Nutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia. AD - Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia. FAU - Houghton, Lisa AU - Houghton L AUID- ORCID: 0000-0002-2276-6205 AD - Department of Human Nutrition, University of Otago, Dunedin, Otago, New Zealand. FAU - Gibson, Rosalind AU - Gibson R AUID- ORCID: 0000-0002-1738-7593 AD - Department of Human Nutrition, University of Otago, Dunedin, Otago, New Zealand. FAU - Hickling, Siobhan AU - Hickling S AUID- ORCID: 0000-0001-8337-2894 AD - School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia. LA - eng GR - OPP1127870/Bill and Melinda Gates Foundation/ GR - Australian Government Research Training Program/ PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 RN - 0 (Micronutrients) RN - 0 (Dietary Proteins) RN - 0 (Biomarkers) RN - J41CSQ7QDS (Zinc) RN - P6YC3EG204 (Vitamin B 12) RN - 11103-57-4 (Vitamin A) RN - 0 (Animal Proteins, Dietary) RN - 0 (Plant Proteins) SB - IM MH - Humans MH - Female MH - *Micronutrients/blood/deficiency/administration & dosage MH - *Lactation MH - Adult MH - *Nutritional Status MH - *Milk, Human/chemistry MH - *Dietary Proteins/administration & dosage MH - Indonesia MH - Animals MH - Biomarkers/blood MH - Zinc/blood MH - *Maternal Nutritional Physiological Phenomena MH - Vitamin B 12/blood MH - *Diet MH - Vitamin A/blood/analysis MH - *Animal Proteins, Dietary/administration & dosage MH - Young Adult MH - Body Mass Index MH - *Plant Proteins/administration & dosage PMC - PMC13599360 COIS- The authors declare no conflicts of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/23 CRDT- 2026/09/23 08:07 PHST- 2026/08/13 00:00 [revised] PHST- 2026/01/17 00:00 [received] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 08:07 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - MCN70253 [pii] AID - 10.1111/mcn.70253 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70253. doi: 10.1111/mcn.70253. PMID- 42775679 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20261016 IS - 1460-6984 (Electronic) IS - 1368-2822 (Print) IS - 1368-2822 (Linking) VI - 61 IP - 6 DP - 2026 Nov-Dec TI - Normative Data and Reliability of the Test of Masticating and Swallowing Solids (TOMASS) in Healthy Brazilian Adults. PG - e70328 LID - 10.1111/1460-6984.70328 [doi] LID - e70328 AB - INTRODUCTION: The Test of Masticating and Swallowing Solids (TOMASS) is a standardized clinical assessment designed to quantify oral phase swallowing efficiency during solid food intake. Although TOMASS has been investigated in several countries, normative data for the Brazilian population are still lacking. OBJECTIVE: To establish normative data and investigate the reliability of the Brazilian Portuguese version of TOMASS in healthy adults. METHODS: This observational cross-sectional study included 99 healthy adults stratified by age group. Individuals with dysphagia, head and neck cancer, neurological disorders, or gastrointestinal diseases were excluded. Participants underwent sociodemographic assessment, Montreal Cognitive Assessment (MoCA), oral structural evaluation, and TOMASS administration using a commercially available Cream Cracker biscuit available in Brazil. All assessments were video-recorded for subsequent analysis. Test-retest reliability was assessed through repeated administrations of TOMASS, and inter-rater reliability was analysed using video recordings. The analysed variables included the number of bites, the number of masticatory cycles, the number of swallows, and total ingestion time. Statistical analyses included Student's t-test, ANOVA with Bonferroni post hoc tests, Wilcoxon test, and ICC coefficient. RESULTS: The sample included 99 healthy adults distributed across three age groups, with 54% women, a mean age of 50.2 (+/-16.3) years, mean education level of 12.4 (+/-4.1) years, and monthly household income equivalent to approximately two minimum wages (US$478 +/- US$228). Significant differences were found between age groups in the number of masticatory cycles (p = 0.021), specifically between the 20-40 and 61+ age groups (p = 0.040). Significant differences were also observed in total task time (p < 0.001), with contrasts between the 20-40 and 61+ groups (p = 0.002), as well as between the 41-60 and 61+ groups (p = 0.013). Test-retest reliability ranged from moderate to excellent, and inter-rater reliability demonstrated good to excellent agreement across TOMASS variables. CONCLUSION: The Brazilian Portuguese version of TOMASS demonstrated satisfactory reliability and applicability for assessing mastication and swallowing performance in healthy Brazilian adults. The present study also provides normative reference data that may support future clinical and research applications of TOMASS in Brazil. WHAT THIS PAPER ADDS: What is already known on the subject The quantitative variables obtained through the TOMASS protocol contribute to the diagnostic accuracy of mastication abilities during a clinical swallowing examination (CSE), supporting more precise clinical decision-making, particularly when compared with previously established normative values. Moreover, the quantitative data allow for monitoring biomechanical changes over time, whether due to natural processes such as aging, neurofunctional maturation, or spontaneous recovery, or attributed to the efficacy of specific therapeutic interventions. What this paper adds to existing knowledge Normative TOMASS data for the Brazilian population may serve as clinical guidelines for assessing chewing and swallowing functions, given that the test is easily integrated into clinical evaluations due to its low cost and quick administration. These data may be especially relevant in contexts where socioeconomic, cultural, and physical barriers, a reality for a significant portion of the Brazilian population, still limit access to healthcare. What are the potential or actual clinical implications of this study? The clinical implications of this study are significant for speech-language pathologists in Brazil and other professionals involved in swallowing assessment and rehabilitation. The establishment of normative TOMASS data for the Brazilian population provides a valuable reference for identifying deviations in mastication performance across age and gender groups. Moreover, in low-resource contexts and developing countries, a brief, easy-to-administer, and low-cost protocol such as TOMASS is especially valuable, enabling equitable access to standardized assessment and monitoring of masticatory and swallowing functions. CI - (c) 2026 The Author(s). International Journal of Language & Communication Disorders published by John Wiley & Sons Ltd on behalf of Royal College of Speech and Language Therapists. FAU - Arcaro, Maria Eduarda Soares AU - Arcaro MES AUID- ORCID: 0000-0002-5321-7671 AD - Postgraduate Program in Medical Science, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. FAU - Bressanelli, Amanda AU - Bressanelli A AUID- ORCID: 0000-0002-5056-5574 AD - Postgraduate Program in Medical Science, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. FAU - Santos, Vanessa Brzoskowski do AU - Santos VBD AUID- ORCID: 0000-0002-2322-3499 AD - Postgraduate Program in Medical Science, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. FAU - Barbosa, Alice AU - Barbosa A AUID- ORCID: 0009-0004-0303-6591 AD - Undergraduate Program in Speech-Language Pathology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. FAU - Bice, Ed AU - Bice E AUID- ORCID: 0000-0002-5753-9133 AD - IOPI Medical, LLC, Woodinville, Washington, USA. FAU - Olchik, Maira Rozenfeld AU - Olchik MR AUID- ORCID: 0000-0002-8732-9225 AD - Postgraduate Program in Medical Science, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. AD - Undergraduate Program in Speech-Language Pathology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. AD - Neurology Service, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil. LA - eng PT - Journal Article PT - Observational Study PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders JID - 9803709 SB - IM MH - Humans MH - Female MH - Male MH - Middle Aged MH - Adult MH - Brazil MH - Reproducibility of Results MH - *Deglutition/physiology MH - Cross-Sectional Studies MH - Reference Values MH - *Mastication/physiology MH - Young Adult MH - Aged MH - Adolescent PMC - PMC13599047 OTO - NOTNLM OT - TOMASS OT - assessment OT - deglutition OT - mastication OT - solid OT - swallowing COIS- The authors declare no conflicts of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/23 CRDT- 2026/09/23 08:03 PHST- 2026/06/05 00:00 [revised] PHST- 2025/11/11 00:00 [received] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 08:03 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - JLCD70328 [pii] AID - 10.1111/1460-6984.70328 [doi] PST - ppublish SO - Int J Lang Commun Disord. 2026 Nov-Dec;61(6):e70328. doi: 10.1111/1460-6984.70328. PMID- 42775081 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260923 LR - 20260924 IS - 2472-0054 (Electronic) IS - 2472-0054 (Linking) VI - 11 IP - 5 DP - 2026 Sep-Oct TI - Optimizing Nutrition in Pediatric Burn Patients: A Quality Improvement Initiative. PG - e918 LID - 10.1097/pq9.0000000000000918 [doi] LID - e918 AB - INTRODUCTION: Pediatric burn patients require up to twice their basal nutritional needs for healing and growth. Perioperative fasting is a modifiable source of nutritional interruption. Recent investigations show that liberalized feeding protocols do not increase aspiration risk. This study aimed to identify and mitigate nutritional barriers in operative pediatric burn patients. METHODS: A multidisciplinary team identified key drivers of prolonged fasting. A standardized protocol was implemented using concentrated feeding formulas, continuing enteral feeds through procedures in intubated patients, and allowing high-protein clear liquids for up to two hours preoperatively in nonintubated patients. Primary outcomes included preoperative fasting duration and caloric and protein intake. Secondary outcomes included length of stay and perioperative complications. RESULTS: Thirty patients were included (15 baseline and 15 intervention). Statistical process control analysis showed sustained reduction in preoperative fasting duration following protocol implementation. Among patients receiving tube feeding, median nil per os duration decreased from 11-hour baseline to 5.6 hours (P < 0.001), whereas caloric and protein intake increased (both P < 0.001). When adjusted for surgical start time and feeding modality, intervention status was associated with shorter fasting duration and increased caloric and protein delivery. No aspiration events occurred. CONCLUSIONS: Perioperative fasting is a contributor to nutritional outcomes in pediatric burn patients. A quality improvement initiative reduced fasting durations and improved perioperative caloric and protein delivery without increasing aspiration risk, impacting length of stay, or increasing perioperative complications. This approach is feasible in centers with varying resources and may be adapted to other pediatric surgical populations. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Sharf, Tamara O AU - Sharf TO AD - From the Division of Trauma and Burn Surgery, Children's National Hospital, Washington, D.C. FAU - Kim, Mary S AU - Kim MS AD - From the Division of Trauma and Burn Surgery, Children's National Hospital, Washington, D.C. FAU - Arkowitz, Dylan W AU - Arkowitz DW AD - From the Division of Trauma and Burn Surgery, Children's National Hospital, Washington, D.C. FAU - Waibel, Elizabeth M AU - Waibel EM AD - From the Division of Trauma and Burn Surgery, Children's National Hospital, Washington, D.C. FAU - Teets, Jonathan M AU - Teets JM AD - Division of Pediatric Anesthesiology, Children's National Hospital, Washington, D.C. FAU - Schug, Samantha AU - Schug S AD - Division of Clinical Nutrition Services, Children's National Hospital, Washington, D.C. FAU - Elliott, Elizabeth C AU - Elliott EC AD - Division of Pediatric Critical Care Medicine, Children's National Hospital, Washington, D.C. FAU - Sharron, Matthew P AU - Sharron MP AD - Division of Pediatric Critical Care Medicine, Children's National Hospital, Washington, D.C. FAU - Burd, Randall S AU - Burd RS AD - From the Division of Trauma and Burn Surgery, Children's National Hospital, Washington, D.C. LA - eng PT - Journal Article DEP - 20260922 PL - United States TA - Pediatr Qual Saf JT - Pediatric quality & safety JID - 101702480 PMC - PMC13596954 EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/22 CRDT- 2026/09/23 07:15 PHST- 2026/02/24 00:00 [received] PHST- 2026/07/24 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 07:15 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - PQS-D-26-00034 [pii] AID - 10.1097/pq9.0000000000000918 [doi] PST - epublish SO - Pediatr Qual Saf. 2026 Sep 22;11(5):e918. doi: 10.1097/pq9.0000000000000918. eCollection 2026 Sep-Oct. PMID- 42774383 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260924 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Nutritional determinants, childhood morbidity patterns, and healthcare utilization among Chinese children: a population-based study. PG - 1909080 LID - 10.3389/fpubh.2026.1909080 [doi] LID - 1909080 AB - BACKGROUND: Childhood nutrition has a substantial impact on growth, disease susceptibility, and use of health care services. Malnutrition is a double burden in China, characterized by chronic undernutrition and childhood obesity. OBJECTIVE: The objective of this study was to explore the relationships between nutrition determinants, childhood morbidity patterns and health care utilization in the Chinese population. METHODOLOGY: This retrospective, institution-based study analyzed routinely collected health records from 720 children aged 3-14 years who received care at a tertiary healthcare center in Nanchong, Sichuan, China, between 2021 and 2025. Nutritional status and dietary quality were determined by using the routine health records. Morbidity burden and service use were assessed using medical records for children. Independent predictors were identified by using multivariable logistic regression. RESULTS: 15.1% of participants were undernourished, and 20.3% were overweight or obese. The childhood morbidity burden was observed in 25.7% of children and was significantly higher in children who were undernourished and obese (p < 0.001). Known-groups validity testing showed that all 9 individual components of the dietary-quality score varied significantly and monotonically across derived tiers (Cochran-Armitage p < 0.001 for all), supporting the internal coherence of the measure. Poor dietary quality, as measured by this study-specific composite index, was an independent risk factor for a high burden of morbidity (Adjusted odds ratio (AOR) = 2.76, 95% CI: 1.89-4.05). High healthcare utilization was observed in 25.8% of participants. It was independently associated with high morbidity burden (AOR = 3.87, 95% CI: 2.71-5.54), undernutrition (AOR = 2.09, 95% CI: 1.37-3.20), obesity (AOR = 2.34, 95% CI: 1.40-3.89), poor dietary quality (AOR = 1.96, 95% CI: 1.32-2.92), low household income (AOR = 1.58, 95% CI: 1.07-2.34), and grandparent caregiving (AOR = 1.45, 95% CI: 1.01-2.11). CONCLUSION: Undernutrition and overweight/obesity, in addition to poor diet quality, are associated with higher morbidity rates and utilization of health services in children in China. The findings suggest that nutritional status and dietary quality are significantly associated with childhood morbidity burden and healthcare utilization. CI - Copyright (c) 2026 Wang, Liao, Zhang, Zhao, Zhang and Huang. FAU - Wang, Pengli AU - Wang P AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Liao, Wenhua AU - Liao W AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Zhang, Li AU - Zhang L AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Zhao, Mingjia AU - Zhao M AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Zhang, Dong AU - Zhang D AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Huang, Nanxiang AU - Huang N AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. LA - eng PT - Journal Article DEP - 20260908 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Female MH - China/epidemiology MH - Child, Preschool MH - Child MH - Retrospective Studies MH - Male MH - *Patient Acceptance of Health Care/statistics & numerical data MH - Adolescent MH - *Nutritional Status MH - Morbidity MH - Malnutrition/epidemiology MH - *Pediatric Obesity/epidemiology MH - East Asian People PMC - PMC13593838 OTO - NOTNLM OT - Chinese children OT - childhood nutrition OT - dietary quality OT - healthcare utilization OT - malnutrition OT - morbidity burden COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/08 CRDT- 2026/09/23 06:13 PHST- 2026/06/14 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 06:13 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1909080 [doi] PST - epublish SO - Front Public Health. 2026 Sep 8;14:1909080. doi: 10.3389/fpubh.2026.1909080. eCollection 2026. PMID- 42774326 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260923 LR - 20260924 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 17 DP - 2026 TI - Cloning of a novel cyanobacterial serotonin N-acetyltransferase gene CySNAT3 and its integration with transcriptomic drug repurposing in pediatric obstructive sleep-disordered breathing. PG - 1851793 LID - 10.3389/fphar.2026.1851793 [doi] LID - 1851793 AB - BACKGROUND: Melatonin has potential therapeutic value in pediatric obstructive sleep-disordered breathing (oSDB). However, plant-based melatonin extraction faces limitations including long growth cycles, low yield, and complex purification procedures. Cyanobacteria, as photosynthetic microorganisms, offer distinct advantages such as rapid growth, low cultivation cost, and well-established genetic manipulation tools, making them ideal chassis cells for producing high-value natural products. Meanwhile, the molecular mechanisms linking tonsillar pathology to oSDB severity remain poorly understood, and translational therapeutic targets are urgently needed. METHODS: A novel cyanobacterial serotonin N-acetyltransferase gene (CySNAT3) was cloned, expressed in E. coli, and purified by Ni-NTA affinity chromatography. Its enzymatic activity was assessed by HPLC-fluorescence. Separately, differential expression analysis, WGCNA, and drug repurposing were performed on tonsillar RNA-seq data (GSE274855), followed by molecular docking to validate drug-target interactions. RESULTS: CySNAT3 catalyzed the conversion of serotonin to N-acetylserotonin and 5-MT to melatonin, providing an enzymatic tool for microbial melatonin production. Four high-confidence candidate drugs (sulfamethoxazole, cimetidine, diethylstilbestrol, clofibrate) were identified, with molecular docking confirming favorable binding affinities to their target proteins (CYP2C19, SLC47A1, WNT7A, SCD). CONCLUSION: Cimetidine and diethylstilbestrol have been experimentally linked to the melatonin pathway, suggesting that these four drugs may act through modulation of melatonin signaling. This study provides a new molecular foundation for pediatric oSDB treatment by integrating a novel cyanobacterial SNAT enzyme tool with transcriptome-derived drug candidates. CI - Copyright (c) 2026 Wen, Xu, Xu, Gao, Song, Lv and Yan. FAU - Wen, Wen AU - Wen W AD - School of Clinical Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China. FAU - Xu, Fei AU - Xu F AD - Department of Neonatology, Shangrao Municipal Hospital, Shangrao, China. FAU - Xu, Yaoming AU - Xu Y AD - Department of Pediatrics, Shangrao Municipal Hospital, Shangrao, China. FAU - Gao, Yifei AU - Gao Y AD - College of Chemistry and Materials Engineering, Quzhou University, Quzhou, China. FAU - Song, Honglin AU - Song H AD - Department of Pediatrics, Rongchang District People's Hospital, Chongqing, China. FAU - Lv, Yang AU - Lv Y AD - Department of Pediatrics, Rongchang District People's Hospital, Chongqing, China. FAU - Yan, Peng AU - Yan P AD - Cardiovascular Department, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China. LA - eng PT - Journal Article DEP - 20260908 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC13593818 OTO - NOTNLM OT - cyanobacteria OT - drug repurposing OT - melatonin OT - obstructive sleep-disordered breathing OT - serotonin N-acetyltransferase COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/08 CRDT- 2026/09/23 06:05 PHST- 2026/04/09 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 06:05 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 1851793 [pii] AID - 10.3389/fphar.2026.1851793 [doi] PST - epublish SO - Front Pharmacol. 2026 Sep 8;17:1851793. doi: 10.3389/fphar.2026.1851793. eCollection 2026. PMID- 42774207 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260923 LR - 20260924 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Adaptation and usability study of the fear of cancer recurrence therapy for parents of survivors of childhood cancer (Parent-FORT). PG - 1815418 LID - 10.3389/fpsyg.2026.1815418 [doi] LID - 1815418 AB - INTRODUCTION: Fear of cancer recurrence (FCR) is a common and distressing concern for caregivers of survivors of cancer. At clinical levels, FCR is persistent, impairs quality of life, increases psychological distress, and increases health-system costs. Emerging evidence suggests that about half of parents of survivors of childhood cancer report clinically significant FCR, with associated negative impacts. No interventions currently target parent FCR. The Fear of Recurrence Therapy (FORT) group intervention efficaciously reduces FCR and improves quality of life for survivors of adult cancer. Our aim was to adapt FORT for virtual delivery for parents of survivors of childhood cancer and evaluate its usability. METHODS: Using the ADAPT and FRAME frameworks, we collaborated with 10 parents with lived experience to modify FORT for this population. Following adaptation, two trained therapists facilitated a usability trial of the adapted program (Parent-FORT) with one group of parents. Therapists and participants completed feedback questionnaires after each session to assess usefulness, usability, and readiness for future users, as well as a final exit interview. Descriptive statistics were used to summarize questionnaire data. Content analysis was used to summarize qualitative data from exit interviews. RESULTS: Five mothers whose children were diagnosed with childhood cancer were enrolled and four (Alberta, n = 2; Ontario, n = 2) completed the usability trial. Significant changes were made to the intervention language and content, resulting in an additional session. Key changes included the addition of exercises on navigating parent-child conversations about new physical symptoms and on exploring identity after cancer. Inclusion criteria were also broadened from one-year post-treatment to one-month post-treatment. Feedback indicated preliminary evidence of usability and acceptability. Qualitative analyses of exit interview data identified four themes: connectedness of the group, general format, satisfaction with the content and exercises, and overall impact. DISCUSSION: Parent-FORT reflects the first FCR intervention designed specifically for parents of survivors of childhood cancer. Meaningful co-design with parents was essential to the success of the adaptation. These preliminary findings support Parent-FORT's readiness for testing in a future feasibility pilot study. CI - Copyright (c) 2026 Holy, Brinson, Gibson-Haerle, Russell, Abbott, Giguere, Givogue, Guilcher, Heathcote, Johnson, McMillan, Maheu, Pelletier, Schulte, Sirois-Leclerc, Tutelman and Lebel. FAU - Holy, Celeste AU - Holy C AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. FAU - Brinson, Jeffery AU - Brinson J AD - Parent Partner, Hamilton, ON, Canada. FAU - Gibson-Haerle, Janelle AU - Gibson-Haerle J AD - Parent Partner, Hamilton, ON, Canada. FAU - Russell, K Brooke AU - Russell KB AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. FAU - Abbott, Lesleigh S AU - Abbott LS AD - Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Giguere, Lauriane AU - Giguere L AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. FAU - Givogue, Amy AU - Givogue A AD - Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Guilcher, Gregory M T AU - Guilcher GMT AD - Section of Pediatric Oncology/Cellular Therapy, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Heathcote, Lauren C AU - Heathcote LC AD - Health Psychology Section, Institute of Psychiatry, Psychology, & Neuroscience, King's College London, London, United Kingdom. FAU - Johnson, Emily AU - Johnson E AD - Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - McMillan, Kimberly AU - McMillan K AD - School of Nursing, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada. FAU - Maheu, Christine AU - Maheu C AD - Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University & Research Institute, Montreal, QC, Canada. FAU - Pelletier, Wendy AU - Pelletier W AD - Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Schulte, Fiona AU - Schulte F AD - Section of Pediatric Oncology/Cellular Therapy, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. AD - Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Sirois-Leclerc, Heloise AU - Sirois-Leclerc H AD - Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Tutelman, Perri R AU - Tutelman PR AD - Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Lebel, Sophie AU - Lebel S AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. LA - eng PT - Journal Article DEP - 20260908 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13593775 OTO - NOTNLM OT - cancer OT - childhood neoplasms OT - fear of cancer recurrence (FCR) OT - group psychotheraphy OT - intervention OT - parents OT - psychology OT - survivors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author CM declared that they were an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/08 CRDT- 2026/09/23 05:52 PHST- 2026/02/22 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 05:52 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1815418 [doi] PST - epublish SO - Front Psychol. 2026 Sep 8;17:1815418. doi: 10.3389/fpsyg.2026.1815418. eCollection 2026. PMID- 42774164 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260924 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Critical and interactive digital health literacy and health information adoption among college students: a cross-sectional serial mediation study from a health communication perspective. PG - 1837883 LID - 10.3389/fpubh.2026.1837883 [doi] LID - 1837883 AB - BACKGROUND: Digital media have transformed how college students access, evaluate, and use health information. Although digital health literacy has been linked with risk perception, preventive behavior, self-care, and information seeking, less is known about its association with health information adoption as a downstream stage of digital health communication and the statistical pathways that may account for this association. OBJECTIVE: This study examined the cross-sectional association between critical and interactive digital health literacy and self-reported health information adoption among college students and estimated the specific indirect associations through health risk perception and exercise self-efficacy, separately and sequentially. METHODS: This cross-sectional study used a structured online questionnaire administered in three batches to college students from 12 institutions in Shandong Province, China, between September and November 2025. An independent pilot sample (n = 331) informed item-level assessment and scale reduction, and 3,148 formal-survey responses were included in the primary analysis. The primary scores were a 10-item health information adoption score, a 9-item critical and interactive digital health literacy score, an 8-item health risk perception score, and a 10-item exercise self-efficacy score. Analyses included descriptive statistics, group comparisons, Pearson correlations, reliability and measurement-model assessment, and ordinary least-squares path models corresponding to PROCESS Model 6. The adjusted model controlled for gender, academic year, major category, residential background, family economic status, and weekly internet-use frequency. Percentile bootstrap confidence intervals were calculated from 5,000 resamples. Analyses were conducted using SPSS 26.0 and Python; additional models assessed survey-batch and alternative-scoring sensitivity. RESULTS: Among the 3,148 participants, the mean scores were 30.83 (SD 8.24) for health information adoption, 29.21 (SD 6.25) for critical and interactive digital health literacy, 26.43 (SD 5.86) for health risk perception, and 32.35 (SD 8.17) for exercise self-efficacy. Digital health literacy was positively correlated with health information adoption (r = 0.416; P < 0.001). In the covariate-adjusted model, the total association between digital health literacy and health information adoption was B = 0.534. The direct association was B = 0.344 (64.3%). The specific indirect associations through health risk perception (effect = 0.090, bootstrap 95% CI 0.058-0.122; 16.9%), exercise self-efficacy (effect = 0.080, bootstrap 95% CI 0.059-0.101; 14.9%), and the serial health-risk-perception-to-exercise-self-efficacy pathway (effect = 0.020, bootstrap 95% CI 0.012-0.029; 3.8%) were statistically detectable. The total indirect association was 0.191 (bootstrap 95% CI 0.150-0.230; 35.7%). Results were materially similar after adjustment for survey batch and under alternative scoring specifications. CONCLUSIONS: Critical and interactive digital health literacy was positively associated with self-reported health information adoption among college students. Health risk perception and exercise self-efficacy provided separate and serial statistical indirect routes, but the direct association was the largest component and the serial route was comparatively small. Because the data were cross-sectional and self-reported, these estimates should be interpreted as statistical decompositions of associations rather than evidence of temporal or causal mediation. CI - Copyright (c) 2026 Sun, Zhao, Zhao and Ma. FAU - Sun, Yi AU - Sun Y AD - College of Basic Medicine, Jining Medical University, Jining, China. FAU - Zhao, Yang AU - Zhao Y AD - College of Foreign Languages, Weifang University, Weifang, Shandong, China. FAU - Zhao, Mingyu AU - Zhao M AD - School of Politics and Public Administration, Qufu Normal University, Rizhao, Shandong, China. FAU - Ma, Qian AU - Ma Q AD - College of Pharmacy, Jining Medical University, Rizhao, China. LA - eng PT - Journal Article DEP - 20260908 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - *Students/statistics & numerical data/psychology MH - Universities MH - *Health Literacy/statistics & numerical data MH - Digital Media MH - Young Adult MH - China MH - Surveys and Questionnaires MH - Digital Health MH - Self Efficacy MH - *Health Communication MH - Adult MH - Adolescent PMC - PMC13593750 OTO - NOTNLM OT - college students OT - cross-sectional study OT - digital health literacy OT - exercise self-efficacy OT - health information adoption OT - health risk perception COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/08 CRDT- 2026/09/23 05:45 PHST- 2026/03/24 00:00 [received] PHST- 2026/08/18 00:00 [revised] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 05:45 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1837883 [doi] PST - epublish SO - Front Public Health. 2026 Sep 8;14:1837883. doi: 10.3389/fpubh.2026.1837883. eCollection 2026. PMID- 42773840 OWN - NLM STAT- Publisher LR - 20260923 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) DP - 2026 Sep 22 TI - Nutrition and Hydration Decisions in Neonatal Palliative Care. LID - 10.1111/jpc.70577 [doi] AB - Medically administered nutrition and hydration (MANH) is a routine component of neonatal intensive care, yet it becomes ethically and emotionally complex when an infant's condition is recognised as life-limiting and care is reoriented towards comfort. Decisions to continue, withhold, or withdraw MANH are challenging because feeding carries profound physiological, emotional, cultural, and relational meaning for families, while neonates cannot reliably communicate hunger, thirst, or discomfort. This commentary examines the ethical, clinical, and legal considerations surrounding MANH at the end of life in neonates and proposes a practical, individualised approach to decision-making. Evidence specifically addressing MANH withdrawal in dying neonates remains limited, requiring clinicians to draw substantially on pediatric and adult palliative care literature. MANH should be regarded as a medical intervention guided by the infant's comfort, proportionality, goals of care, and best interests rather than an assumed moral obligation. Its potential benefits, including relief of hunger or thirst, preservation of parental caregiving roles, and cultural or spiritual significance, warrant explicit recognition. Comfort feeding should be considered where tolerated, with MANH continued when it provides meaningful benefit and reconsidered when it causes discomfort, imposes significant burdens, or prolongs dying without corresponding benefit. Australian and international legal frameworks broadly support withdrawal where MANH is non-beneficial. Clear communication, shared decision-making, cultural humility, multidisciplinary consensus, and regular reassessment are essential. Further prospective research is needed to better understand hunger, thirst, comfort, survival trajectories, and parental experiences following MANH withdrawal in dying neonates. CI - (c) 2026 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Trivedi, Amit AU - Trivedi A AUID- ORCID: 0000-0002-6880-4107 AD - Grace Centre for Newborn Intensive Care, the Children's Hospital at Westmead, Westmead, New South Wales, Australia. AD - Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Badawi, Nadia AU - Badawi N AUID- ORCID: 0000-0001-6828-1636 AD - Grace Centre for Newborn Intensive Care, the Children's Hospital at Westmead, Westmead, New South Wales, Australia. AD - Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Cerebral Palsy Alliance Research Institute, Allambie Heights, New South Wales, Australia. FAU - Carter, Brian S AU - Carter BS AUID- ORCID: 0000-0003-0539-9164 AD - Bioethics Centre, Children's Mercy-Kansas City, Kansas City, Missouri, USA. AD - Department of Medical Humanities and Bioethics, The University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA. FAU - Moustafa, Ahmed AU - Moustafa A AUID- ORCID: 0000-0001-7754-6296 AD - Grace Centre for Newborn Intensive Care, the Children's Hospital at Westmead, Westmead, New South Wales, Australia. AD - Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Preisz, Anne AU - Preisz A AUID- ORCID: 0000-0003-4331-1434 AD - Faculty of Medicine and Health, Sydney Health Ethics, The University of Sydney, Sydney, New South Wales, Australia. AD - School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia. LA - eng PT - Journal Article PT - Review DEP - 20260922 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM OTO - NOTNLM OT - medical ethics OT - medically administered nutrition and hydration OT - neonatal palliative care OT - shared decision-making EDAT- 2026/09/23 05:35 MHDA- 2026/09/23 05:35 CRDT- 2026/09/23 03:03 PHST- 2026/08/11 00:00 [revised] PHST- 2025/12/23 00:00 [received] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/23 05:35 [medline] PHST- 2026/09/23 05:35 [pubmed] PHST- 2026/09/23 03:03 [entrez] AID - 10.1111/jpc.70577 [doi] PST - aheadofprint SO - J Paediatr Child Health. 2026 Sep 22. doi: 10.1111/jpc.70577. PMID- 42773386 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20260925 IS - 1554-3528 (Electronic) IS - 1554-351X (Print) IS - 1554-351X (Linking) VI - 58 IP - 11 DP - 2026 Sep 22 TI - Creating and validating photorealistic AI-generated facial expression stimuli for emotion research. LID - 10.3758/s13428-026-03156-0 [doi] LID - 296 AB - The development of AI-generated facial expression stimuli offers researchers unprecedented control over stimulus characteristics while maintaining photorealistic quality. However, rigorous validation methodologies are essential to ensure these stimuli function effectively in behavioral research. This paper presents a comprehensive three-study validation framework for AI-generated facial expression stimuli that systematically varied body weight and emotional expressions. Study 1 validated 72 stimuli across three emotions (happiness, sadness, neutrality) and three weight categories using both computational and human validation approaches. Study 2 extended this framework to include anger as a fourth emotion while controlling for individual facial features through same-character methodology. Study 2b further assessed valence, intensity, naturalness, authenticity, and non-focal emotion ratings of the same stimuli from Study 2. Across studies, the stimuli demonstrated successful emotion and weight manipulations, with AI-generated images achieving photorealistic quality that participants could not reliably distinguish from real photographs. Computational validation showed high intended-emotion likelihood in Py-Feat, while human validation confirmed appropriate perception of the target emotions, body weight, realism, age, and broader expression-quality dimensions. This dual validation approach-combining automated computational assessment with human behavioral validation-provides a robust framework for ensuring AI-generated stimuli meet research standards. The methodology offers significant advantages for behavioral research, enabling precise control over stimulus characteristics while maintaining ecological validity and addressing ethical considerations in stimulus development. CI - (c) 2026. The Author(s). FAU - Hareli, Shlomo AU - Hareli S AD - The Laboratory for the Study of Social Perception of Emotions, School of Business Administration, The Herta & Paul Amir Faculty of Social Sciences, University of Haifa, 199 Aba Khoushy Ave., Mount Carmel, Israel. shareli@univ.haifa.ac.il. FAU - David, Shlomo AU - David S AD - The Laboratory for the Study of Social Perception of Emotions, School of Business Administration, The Herta & Paul Amir Faculty of Social Sciences, University of Haifa, 199 Aba Khoushy Ave., Mount Carmel, Israel. LA - eng PT - Journal Article PT - Validation Study DEP - 20260922 PL - United States TA - Behav Res Methods JT - Behavior research methods JID - 101244316 SB - IM MH - Humans MH - *Facial Expression MH - *Emotions/physiology MH - Female MH - Male MH - Adult MH - Young Adult MH - Generative Artificial Intelligence MH - *Photic Stimulation/methods MH - Adolescent MH - Reproducibility of Results MH - Body Weight PMC - PMC13597571 OTO - NOTNLM OT - Artificial intelligence OT - Body weight OT - Emotion perception OT - Facial expressions OT - Stimulus validation COIS- Declarations. Ethics approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. The study was approved by the Ethics Committee of The Herta & Paul Amir Faculty of Social Sciences, University of Haifa (No. 381/24). Consent to participate: Informed consent was obtained from all participants prior to their participation. Consent for publication: All participants provided consent for their anonymized data to be used for research purposes. Conflicts of interest/Competing interests: The authors have no competing interests to declare. Open practices statement: All validation data, participant responses, generated stimulus datasets, and supplementary materials are openly available via OSF at: https://osf.io/mbg4j/?view_only=a0c0512fa2b04cc19c335cc2bd299017 . This includes complete raw datasets for all studies, data codebooks, all AI-generated stimuli, PyFeat and FaceShape analysis results, complete analysis reports, and supplementary materials. All computational code and workflows are openly available in the same OSF repository, including R Markdown files, Python scripts, ComfyUI workflow specifications (.json files), LoRA models (.safetensors files), and step-by-step instructions. AI assistance disclosure: During the preparation of this work, the authors used Claude AI to assist with developing the Py-Feat validation script and improving language. To ensure scientific accuracy, all AI-generated outputs were thoroughly reviewed by the authors. The authors take full responsibility for the content of the publication. EDAT- 2026/09/23 05:35 MHDA- 2026/09/23 05:36 PMCR- 2026/09/22 CRDT- 2026/09/22 23:34 PHST- 2025/08/05 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/09/23 05:36 [medline] PHST- 2026/09/23 05:35 [pubmed] PHST- 2026/09/22 23:34 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - 10.3758/s13428-026-03156-0 [pii] AID - 3156 [pii] AID - 10.3758/s13428-026-03156-0 [doi] PST - epublish SO - Behav Res Methods. 2026 Sep 22;58(11):296. doi: 10.3758/s13428-026-03156-0. PMID- 42773043 OWN - NLM STAT- Publisher LR - 20260922 IS - 1578-1879 (Electronic) IS - 0214-9168 (Linking) DP - 2026 Sep 22 TI - Early-life atherogenesis: Mechanistic pathways, risk architecture, and clinical implications in pediatric populations. PG - 500964 LID - S0214-9168(26)00073-2 [pii] LID - 10.1016/j.arteri.2026.500964 [doi] AB - Atherosclerosis is now recognized as a long-term biological process whose origins may be established early in life, well before the clinical expression of cardiovascular disease. The increasing prevalence of pediatric obesity, insulin resistance, sedentary behavior, and unhealthy dietary patterns has intensified interest in understanding how vascular risk is shaped from childhood onward. This narrative review examines early-life atherogenesis in pediatric populations from mechanistic, clinical, and preventive perspectives, with emphasis on cardiometabolic risk factors, endothelial dysfunction, vascular inflammation, and potential biomarkers of subclinical vascular injury. A narrative synthesis of current evidence was conducted to integrate mechanistic, clinical, and preventive aspects of pediatric atherogenesis, focusing on biological pathways, developmental determinants, lifestyle-related exposures, and emerging tools for early risk stratification. Sustained exposure to adverse cardiometabolic factors during childhood and adolescence may promote subclinical vascular alterations and establish risk trajectories that persist into adulthood. This process involves the interaction of atherogenic dyslipidemia, oxidative stress, chronic low-grade inflammation, immune activation, endothelial dysfunction, and vascular remodeling. Circulating biomarkers of endothelial activation and vascular inflammation may serve as early indicators of subclinical injury and provide complementary information for identifying children with increased cardiometabolic vulnerability. Genetic susceptibility, pubertal development, sex-related differences, socioeconomic conditions, and lifestyle-related factors further modulate the expression and severity of risk. Early identification of children with unfavorable cardiometabolic profiles requires the integration of conventional clinical assessment with biomarkers, derived lipid parameters, and complementary stratification tools that still require further pediatric validation. Understanding pediatric atherogenesis as an integrated process shaped by biology, development, and environment may help guide more timely strategies for prevention, follow-up, and intervention aimed at reducing future cardiovascular burden. CI - Copyright (c) 2026 Sociedad Espanola de Arteriosclerosis. Publicado por Elsevier Espana, S.L.U. All rights reserved. FAU - de la Torre-Sosa, Citlaly Natali AU - de la Torre-Sosa CN AD - Departamento de Salud, El Colegio de la Frontera Sur (ECOSUR), Unidad Villahermosa, Carretera a Reforma Km. 15.5 s/n, Rancheria Guineo 2da Seccion, CP 86280, Villahermosa, Tabasco, Mexico. FAU - Lopez-Marure, Rebeca AU - Lopez-Marure R AD - Departamento de Fisiologia (Biologia Celular), Instituto Nacional de Cardiologia "Ignacio Chavez", Tlalpan, CP 14080, Ciudad de Mexico, Mexico. FAU - Ochoa-Diaz-Lopez, Hector AU - Ochoa-Diaz-Lopez H AD - Departamento de Salud, El Colegio de la Frontera Sur (ECOSUR), Unidad San Cristobal, San Cristobal de las Casas, Chiapas, Mexico. FAU - Irecta-Najera, Cesar Antonio AU - Irecta-Najera CA AD - Departamento de Salud, El Colegio de la Frontera Sur (ECOSUR), Unidad Villahermosa, Carretera a Reforma Km. 15.5 s/n, Rancheria Guineo 2da Seccion, CP 86280, Villahermosa, Tabasco, Mexico. Electronic address: cirecta@ecosur.mx. LA - eng LA - spa PT - Journal Article PT - Review DEP - 20260922 PL - Spain TA - Clin Investig Arterioscler JT - Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis JID - 9208512 SB - IM OTO - NOTNLM OT - Aterogenesis OT - Atherogenesis OT - Cardiovascular risk factors OT - Epidemiology OT - Epidemiologia OT - Factores de riesgo cardiovascular OT - Pediatric population OT - Poblacion pediatrica EDAT- 2026/09/22 23:33 MHDA- 2026/09/22 23:33 CRDT- 2026/09/22 21:57 PHST- 2026/06/11 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/22 23:33 [medline] PHST- 2026/09/22 23:33 [pubmed] PHST- 2026/09/22 21:57 [entrez] AID - S0214-9168(26)00073-2 [pii] AID - 10.1016/j.arteri.2026.500964 [doi] PST - aheadofprint SO - Clin Investig Arterioscler. 2026 Sep 22:500964. doi: 10.1016/j.arteri.2026.500964. PMID- 42772898 OWN - NLM STAT- Publisher LR - 20260922 IS - 1468-3296 (Electronic) IS - 0040-6376 (Linking) DP - 2026 Sep 22 TI - Systematic misclassification of lung function in Indian adolescents using GLI-2012 reference equations: evidence from the multicity APEAL cohort. LID - thorax-2026-225309 [pii] LID - 10.1136/thorax-2026-225309 [doi] AB - BACKGROUND: Accurate spirometric interpretation depends on appropriate reference equations. The Global Lung Function Initiative (GLI-2012) equations are widely used internationally, but South Asian populations were sparsely represented in their derivation and their applicability in Indian adolescents remains uncertain. METHODS: We performed a cross-sectional analysis of baseline data from the multicity Air Pollution Exposure on Adolescents' Lungs cohort. Healthy, non-smoking school-going adolescents aged 11-14 years from Delhi, Mumbai, Bengaluru and Mysuru underwent spirometry using standardised American Thoracic Society/European Respiratory Society procedures. GLI-2012 z-scores for forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC were calculated using the Asian reference category. Fit was assessed using mean z-scores and the proportion below the lower limit of normal (LLN; z<-1.645). RESULTS: Among 4175 adolescents (2148 males), mean z-scores were -2.44 (SD 1.27) for FEV(1), -1.34 (0.93) for FVC and -0.78 (1.11) for FEV(1)/FVC, all well outside the accepted +/-0.5 range for adequate fit. Overall, 74.6% were below the LLN for FEV(1), 36.8% for FVC and 19.3% for FEV(1)/FVC, compared with the expected 5% in a well-calibrated healthy population. The leftward shift in z-score distributions was consistent across sex, city, age, height and body mass index strata. CONCLUSION: GLI-2012 equations, as currently applied in the absence of South Asian-specific references, demonstrated substantial calibration mismatch relative to this cohort of Indian adolescents and risk major overclassification of low lung function. Population-specific validation and recalibration are needed before routine clinical or epidemiological use in this population. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Samdarshi, Priya AU - Samdarshi P AUID- ORCID: 0009-0007-6396-0876 AD - Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India. FAU - Mahesh, Padukudru Anand AU - Mahesh PA AUID- ORCID: 0000-0003-1632-5945 AD - Respiratory Medicine, JSS Medical College and Hospital, Mysore, Karnataka, India. FAU - Patil, Swapnali AU - Patil S AD - Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India. FAU - Mohan, Anant AU - Mohan A AD - Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences New Delhi, New Delhi, Delhi, India. FAU - D'Souza, George AU - D'Souza G AD - Department of Pulmonary Medicine, St John's Medical College, Bengaluru, Karnataka, India. FAU - Thimmulappa, Rajesh AU - Thimmulappa R AD - Department of Biochemistry, JSS Medical College, Mysuru, Karnataka, India. FAU - Agrawal, Twinkle AU - Agrawal T AD - Department of Community Health, St John's National Academy of Health Sciences, Bengaluru, Karnataka, India. FAU - Biligere Siddaiah, Jayaraj AU - Biligere Siddaiah J AD - Department of Respiratory Medicine, JSS Medical College, Mysuru, Karnataka, India. FAU - Phuleria, Harish Chandra AU - Phuleria HC AD - Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India phuleria@iitb.ac.in. AD - Centre for Climate Studies, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India. LA - eng PT - Journal Article DEP - 20260922 PL - England TA - Thorax JT - Thorax JID - 0417353 SB - IM OTO - NOTNLM OT - Forced Expiratory Volume OT - Respiratory Function Tests OT - Respiratory Infection OT - Respiratory Measurement COIS- Competing interests: None declared. EDAT- 2026/09/22 23:33 MHDA- 2026/09/22 23:33 CRDT- 2026/09/22 21:23 PHST- 2026/04/25 00:00 [received] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/22 23:33 [medline] PHST- 2026/09/22 23:33 [pubmed] PHST- 2026/09/22 21:23 [entrez] AID - thorax-2026-225309 [pii] AID - 10.1136/thorax-2026-225309 [doi] PST - aheadofprint SO - Thorax. 2026 Sep 22:thorax-2026-225309. doi: 10.1136/thorax-2026-225309. PMID- 42772725 OWN - NLM STAT- Publisher LR - 20260922 IS - 1543-2920 (Electronic) IS - 0899-8493 (Linking) DP - 2026 Sep 22 TI - Test-Retest Reliability of In Vivo Structure and Mechanical Properties of the Achilles Tendon in Youth With Obesity. PG - 1-9 LID - 10.1123/pes.2025-0127 [doi] AB - PURPOSE: To assess the test-retest reliability of in vivo Achilles tendon (AT) structure and mechanical properties in youth with obesity. METHODS: Participants (11 males; 12 females; age: 12.00 [2.07] y; body mass index z score: 2.93 [0.59]) were assessed for AT (1) length, (2) cross-sectional area, (3) moment arm, (4) force, (5) deformation, (6) stress, (7) strain, (8) stiffness, (9) Young's modulus, (10) plantar flexor maximal isometric voluntary contraction, and (11) tibialis anterior co-activation. Reliability was assessed using the intraclass correlation coefficient, coefficient of variation, Bland-Altman, standard error of the measurement, and minimum detectable change. The intraclass correlation coefficient values were classified as excellent (>/=.90), good (>/=.75 to <.90), moderate (>.49 to <.75), and poor ( control beliefs [95% CI (0.1135, 0.2500)]. Perceived susceptibility and barriers were indirectly related to lower control beliefs, and this relationship did not operate through attitude. Subjective norm was associated with intention, fully mediated by control beliefs (Effect = 0.3505). Control beliefs showed the largest predictive effect size on intention in the present model (beta = 0.824, p < 0.001). CONCLUSION: Continuous post-injury exercise intention was associated with a stepwise path of attitude --> control beliefs --> intention. Perceived health benefits were associated with intention through this chain, while the pattern for perceived severity was consistent with fear-avoidance theory. Control beliefs connected internal values and social norms. The findings suggest that interventions may benefit from shifting from risk intimidation to benefit empowerment, and from reconstructing rehabilitation control through social support networks-though these candidate directions await experimental validation. CI - Copyright (c) 2026 Hu and Chen. FAU - Hu, Xuanming AU - Hu X AD - School of Sports Science and Physical Education, Nanjing Normal University, Nanjing, Jiangsu, China. FAU - Chen, Peiyou AU - Chen P AD - School of Sports Science and Physical Education, Nanjing Normal University, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260907 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Intention MH - Theory of Planned Behavior MH - *Athletic Injuries/rehabilitation/psychology MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Universities MH - *Exercise/psychology MH - *Health Belief Model MH - Self Efficacy MH - *Students/psychology/statistics & numerical data MH - Surveys and Questionnaires MH - Adult MH - Adolescent PMC - PMC13590716 OTO - NOTNLM OT - Health Belief Model OT - Theory of Planned Behavior OT - chained mediation model OT - control beliefs regarding exercise rehabilitation OT - university students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/22 12:42 MHDA- 2026/09/22 12:43 PMCR- 2026/09/07 CRDT- 2026/09/22 05:43 PHST- 2026/05/29 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/22 12:43 [medline] PHST- 2026/09/22 12:42 [pubmed] PHST- 2026/09/22 05:43 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1894556 [doi] PST - epublish SO - Front Public Health. 2026 Sep 7;14:1894556. doi: 10.3389/fpubh.2026.1894556. eCollection 2026. PMID- 42769148 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20260924 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Effects of fun games on respiratory function and compliance in children with pneumonia: a randomized controlled trial. PG - 1824969 LID - 10.3389/fpubh.2026.1824969 [doi] LID - 1824969 AB - BACKGROUND: Community-acquired pneumonia poses a significant threat to children's health. Traditional respiratory rehabilitation often suffers from poor adherence due to children's limited cognitive abilities. This study aimed to evaluate the effects of a fun game-based intervention on respiratory function, exercise capacity, and rehabilitation compliance in children with pneumonia. METHODS: A single-center, two-arm, parallel-group randomized controlled trial was conducted. A total of 170 children recovering from pneumonia and meeting the inclusion criteria were recruited from a tertiary hospital in Shenzhen and randomly allocated to either an intervention group or a control group. Ultimately, 154 participants (77 per group) completed the study. The control group received conventional respiratory training and health education. The intervention group participated in an 8-week fun game-based program, including respiratory training games (e.g., "Blow Out the Little Candle"), physical activity games (e.g., "Rhythmic Breathing Run"), along with interactive feedback mechanisms and personalized adjustments. Pulmonary function (FEV1/FVC ratio), exercise capacity (6-min walk distance, 6MWD), and rehabilitation compliance (Frankl and Houpt scale scores) were measured in both groups before and after the intervention. RESULTS: No statistically significant differences were found in baseline characteristics or outcome measures between the two groups before the intervention (P > 0.05). After the 8-week intervention, the intervention group showed significantly greater improvement in pulmonary function (FEV1/FVC: 84.69 +/- 2.34 vs. 74.43 +/- 2.27, P < 0.001) and exercise capacity (6MWD: 593.63 +/- 19.91 m vs. 556.35 +/- 30.48 m, P < 0.001) compared to the control group. Regarding compliance, post-intervention Frankl scores (3.87 +/- 0.34 vs. 3.10 +/- 0.60) and Houpt scores (2.91 +/- 0.86 vs. 3.19 +/- 0.78) indicated significantly better cooperation willingness and treatment completion in the intervention group (P < 0.05). CONCLUSION: The fun game-based intervention significantly improves pulmonary function and exercise capacity, while effectively enhancing compliance and completion rates in the rehabilitation of children with pneumonia. This approach is economical, feasible, and effective, offering a novel strategy for clinical nursing and rehabilitation practice in pediatric pneumonia. CLINICAL TRIAL REGISTRATION: https://www.chictr.org.cn/showproj.html?proj=269965. CI - Copyright (c) 2026 Chen, He, Gong, Wang, Chen, Zhuang and Ye. FAU - Chen, Ying AU - Chen Y AD - Department of Pediatrics, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, China. FAU - He, Xin AU - He X AD - Department of Pediatrics, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, China. FAU - Gong, Jin AU - Gong J AD - Department of Pediatrics, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, China. FAU - Wang, Qin AU - Wang Q AD - Department of Pediatrics, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, China. FAU - Chen, Ting AU - Chen T AD - Department of Pediatrics, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, China. FAU - Zhuang, Yanyun AU - Zhuang Y AD - Department of Pediatrics, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, China. FAU - Ye, Liqin AU - Ye L AD - Department of Pediatrics, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260907 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - China MH - *Community-Acquired Pneumonia/rehabilitation MH - *Games, Recreational MH - *Patient Compliance/statistics & numerical data MH - Respiratory Function Tests PMC - PMC13590701 OTO - NOTNLM OT - children OT - fun games OT - pneumonia OT - rehabilitation compliance OT - respiratory function COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/22 12:42 MHDA- 2026/09/22 12:43 PMCR- 2026/09/07 CRDT- 2026/09/22 05:09 PHST- 2026/03/07 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/22 12:43 [medline] PHST- 2026/09/22 12:42 [pubmed] PHST- 2026/09/22 05:09 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1824969 [doi] PST - epublish SO - Front Public Health. 2026 Sep 7;14:1824969. doi: 10.3389/fpubh.2026.1824969. eCollection 2026. PMID- 42769082 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20260923 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Age- and body surface area-specific ultrasound percentile charts for thyroid volume in Polish school-aged children: comparison with European cohorts. PG - 1945848 LID - 10.3389/fendo.2026.1945848 [doi] LID - 1945848 AB - OBJECTIVE: To establish age- and body surface area (BSA)-specific ultrasound percentile charts for thyroid volume (Tvol) in Polish school-aged children born after the introduction of mandatory iodine prophylaxis, and to compare these values with previous national, WHO, and recent European reference data. DESIGN: Nationwide cross-sectional analysis of iodine-monitoring data. Methods: The source database contained 10,456 screening records from the National Program for the Elimination of Iodine Deficiency in Poland. After hierarchical exclusions, 3,170 children aged 6-13 years with valid thyroid-volume data were included in the age-specific analysis; 2,843 children with complete anthropometric data were included in analyses requiring BSA. Age- and BSA-specific percentile curves (P3-P97) were generated, and multivariable linear regression was performed to identify independent predictors of Tvol. RESULTS: Median urinary iodine concentration (UIC) exceeded 100 microg/L across all age groups, confirming iodine sufficiency at the population level. Median Tvol increased with age from 2.7 to 7.4 mL in girls and from 2.8 to 6.8 mL in boys. The 97th percentile increased from 4.5 to 12.9 mL in girls and from 4.3 to 13.6 mL in boys. BSA was the strongest independent predictor of Tvol, followed by age. Compared with WHO 2004 reference values, the proposed percentiles were consistently higher and closely aligned with recent European data. CONCLUSIONS: This study provides population-specific ultrasound percentile charts for thyroid volume in iodine-sufficient Polish children. These charts complement existing WHO and European references and may improve the interpretation of pediatric thyroid ultrasound in Poland and comparable Central European populations. CI - Copyright (c) 2026 Nowak, Trofimiuk-Muldner, Podlewski, Buziak-Bereza, Sokolowski, Ruchala, Adamczewski, Zygmunt, Sworczak and Hubalewska-Dydejczyk. FAU - Nowak, Andrzej AU - Nowak A AD - Department of Endocrinology, Endocrine Oncology, Nuclear Medicine and Internal Diseases, University Hospital in Krakow, Krakow, Poland. FAU - Trofimiuk-Muldner, Malgorzata AU - Trofimiuk-Muldner M AD - Jagiellonian University Medical College, Chair and Department of Endocrinology, Krakow, Poland. FAU - Podlewski, Jacek AU - Podlewski J AD - Dover Fueling Solutions, Krakow, Poland. FAU - Buziak-Bereza, Monika AU - Buziak-Bereza M AD - Jagiellonian University Medical College, Chair and Department of Endocrinology, Krakow, Poland. FAU - Sokolowski, Grzegorz AU - Sokolowski G AD - Jagiellonian University Medical College, Chair and Department of Endocrinology, Krakow, Poland. FAU - Ruchala, Marek AU - Ruchala M AD - Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland. FAU - Adamczewski, Zbigniew AU - Adamczewski Z AD - Department of Nuclear Medicine, Medical University of Lodz, Lodz, Poland. AD - Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland. FAU - Zygmunt, Arkadiusz AU - Zygmunt A AD - Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland. AD - Department of Pediatric and Adult Endocrinology, Medical University of Lodz, Lodz, Poland. FAU - Sworczak, Krzysztof AU - Sworczak K AD - Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland. FAU - Hubalewska-Dydejczyk, Alicja AU - Hubalewska-Dydejczyk A AD - Jagiellonian University Medical College, Chair and Department of Endocrinology, Krakow, Poland. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260907 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 9679TC07X4 (Iodine) SB - IM MH - Humans MH - Child MH - Male MH - *Thyroid Gland/diagnostic imaging MH - Female MH - Poland/epidemiology MH - Adolescent MH - Ultrasonography/methods MH - Cross-Sectional Studies MH - *Body Surface Area MH - Iodine/urine/deficiency MH - Reference Values MH - Age Factors MH - Organ Size PMC - PMC13590292 OTO - NOTNLM OT - Poland OT - body surface area OT - children OT - iodine sufficiency OT - percentile charts OT - thyroid volume OT - ultrasound OT - urinary iodine concentration COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author MR declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/22 05:37 MHDA- 2026/09/22 12:42 PMCR- 2026/09/07 CRDT- 2026/09/22 05:00 PHST- 2026/07/22 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/22 12:42 [medline] PHST- 2026/09/22 05:37 [pubmed] PHST- 2026/09/22 05:00 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.3389/fendo.2026.1945848 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 7;17:1945848. doi: 10.3389/fendo.2026.1945848. eCollection 2026. PMID- 42768963 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261027 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 44 IP - 22 DP - 2026 Nov TI - Coaches' verbal encouragement in soccer: A systematic review of its effects on internal training load, physical and time-motion performance, and technical skills. PG - 3157-3171 LID - 10.1080/02640414.2026.2735708 [doi] AB - This systematic review synthesized evidence on coaches' verbal encouragement (VE) effects on internal training load, physical and time-motion performance, and technical skills in soccer. PubMed, Web of Science, SPORTDiscus, and PsycInfo were searched up to 1 June 2025, for randomized and quasi-experimental VE interventions in male or female players of any age or competitive level. Outcomes included internal training load (heart rate [HR], blood lactate, perceived exertion [RPE]), physical and time-motion performance (e.g. distance covered, high-intensity running, sprint performance), and technical skills (e.g. passing, dribbling). Methodological quality was assessed using the JBI checklist. Eighteen studies (n = 518) met the inclusion criteria. VE increased internal training load in 11/13 studies, most often showing small-to-moderate increases in RPE and HR responses. Physical and time-motion outcomes improved in 6/8 studies, typically through greater total distance and high-intensity running, and technical performance improved in 8/9 studies (higher success rates and/or increased frequency of technical actions). Effects were most consistent in youth and amateur players; findings in elite youth and professionals were mixed. VE represents a feasible, low-cost strategy that may increase internal training load and enhance selected physical, time-motion, and technical outcomes. Future studies should standardize VE protocols and test dose-response and long-term effects. FAU - Selmi, Okba AU - Selmi O AUID- ORCID: 0000-0001-5309-8863 AD - Sport Sciences, Health and Movement, University of Jendouba, Kef, Tunisia. AD - High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Marzouki, Hamza AU - Marzouki H AUID- ORCID: 0000-0002-5695-1433 AD - Sport Sciences, Health and Movement, University of Jendouba, Kef, Tunisia. AD - High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Bouassida, Anissa AU - Bouassida A AUID- ORCID: 0000-0003-0971-0183 AD - Sport Sciences, Health and Movement, University of Jendouba, Kef, Tunisia. AD - High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Ammar, Achraf AU - Ammar A AUID- ORCID: 0000-0003-0347-8053 AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany. AD - Research Laboratory, Molecular Bases of Human Pathology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia. AD - Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman, Jordan. FAU - Soylu, Yusuf AU - Soylu Y AUID- ORCID: 0000-0003-0609-0601 AD - Faculty of Sports Sciences, Tokat Gaziosmanpasa University, Tokat, Turkiye. FAU - Boukhris, Omar AU - Boukhris O AUID- ORCID: 0000-0002-2861-0164 AD - SIESTA Research Group, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia. AD - Sport, Performance, and Nutrition Research Group, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia. FAU - Husain, Waqar AU - Husain W AUID- ORCID: 0000-0003-1508-4174 AD - Department of Humanities, COMSATS University Islamabad, Islamabad, Pakistan. FAU - Jahrami, Haitham AU - Jahrami H AUID- ORCID: 0000-0001-8990-1320 AD - Government Hospitals, Manama, Bahrain. AD - Department of Psychiatry, College of Medicine and Health Sciences, Arabian Gulf University, Manama, Bahrain. FAU - Trabelsi, Khaled AU - Trabelsi K AUID- ORCID: 0000-0003-2623-9557 AD - Research Laboratory: Education, Motricity, Sport and Health, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. AD - Department of Movement Sciences and Sports Training, School of Sport Science, The University of Jordan, Amman, Jordan. AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20260922 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 RN - 33X04XA5AT (Lactic Acid) SB - IM MH - Humans MH - *Soccer/physiology/psychology MH - *Athletic Performance/physiology/psychology MH - Heart Rate MH - *Physical Conditioning, Human/psychology/methods MH - Physical Exertion/physiology MH - Lactic Acid/blood MH - *Motor Skills/physiology MH - Time and Motion Studies MH - Perception/physiology MH - Running/physiology MH - *Verbal Behavior MH - Male MH - Female OTO - NOTNLM OT - Coach encouragement OT - heart rate responses OT - motivational feedback OT - perceived exertion OT - physical fitness OT - team sports EDAT- 2026/09/22 05:37 MHDA- 2026/10/25 03:35 CRDT- 2026/09/22 03:52 PHST- 2026/10/25 03:35 [medline] PHST- 2026/09/22 05:37 [pubmed] PHST- 2026/09/22 03:52 [entrez] AID - 10.1080/02640414.2026.2735708 [doi] PST - ppublish SO - J Sports Sci. 2026 Nov;44(22):3157-3171. doi: 10.1080/02640414.2026.2735708. Epub 2026 Sep 22. PMID- 42768931 OWN - NLM STAT- Publisher LR - 20260922 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Sep 22 TI - Disability in pediatric inflammatory bowel diseases: A systematic review and a single center experience. LID - 10.1002/jpn3.70596 [doi] AB - OBJECTIVES: Toward development of a pediatric IBD disability index (PIDI), we aimed to review the literature on disability in pediatric inflammatory bowel disease (PIBD) and to estimate disability rates in a pediatric inception cohort. METHODS: A systematic review identified studies reporting disability in PIBD and in adult randomized controlled trials (RCTs) with disability as the primary outcome. In parallel, seven disability-related IMPACT-III items were retrieved at 4 and 12 months after diagnosis from a prospectively followed inception cohort of PIBD. Items were scored 0-100 (/=15 years of age and residents of Saskatchewan. Participants will complete four home visits over the study period. Baseline home visits will occur when infants are approximately 2 months of age, during which frozen PDHM will be delivered to homes. PDHM will be used as a supplement to infant formula or breastfeeding. Caregivers will record PDHM usage and infant tolerance using structured tracking forms. Follow-up visits will occur every 2-3 weeks for PDHM delivery and bottle counts, with weekly check-ins for support. Clinical pilot data will include infant anthropometrics and serious illness events collected during study visits and abstracted from medical records. Descriptive analyses will summarise PDHM intake, tolerance and caregiver experiences. ETHICS AND DISSEMINATION: Ethical approval was obtained from the University of Saskatchewan Biomedical Research Ethics Board (BIO 5307) and the Saskatchewan Health Authority. Findings will be disseminated through peer-reviewed publications and conference presentations. TRIAL REGISTRATION NUMBER: NCT06955715. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Langen, Chloe AU - Langen C AUID- ORCID: 0009-0001-7659-2298 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada. FAU - Blackburn, David AU - Blackburn D AUID- ORCID: 0000-0002-7831-5913 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada. FAU - Purewal, Rupeena AU - Purewal R AD - College of Medicine, University of Saskatchewan, Saskatoon, Canada. FAU - Cochrane, Kelsey M AU - Cochrane KM AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada Kelsey.Cochrane@usask.ca. LA - eng SI - ClinicalTrials.gov/NCT06955715 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260921 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Adult MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - Breast Feeding MH - Caregivers MH - Feasibility Studies MH - *HIV Infections/transmission/prevention & control MH - *Infectious Disease Transmission, Vertical/prevention & control MH - *Milk, Human MH - *Pasteurization MH - Saskatchewan MH - Clinical Trials as Topic PMC - PMC13599818 OTO - NOTNLM OT - Caregivers OT - HIV & AIDS OT - Health Equity OT - Paediatric infectious disease & immunisation OT - Public health COIS- Competing interests: None declared. EDAT- 2026/09/21 23:33 MHDA- 2026/09/21 23:34 PMCR- 2026/09/21 CRDT- 2026/09/21 20:54 PHST- 2026/09/21 23:34 [medline] PHST- 2026/09/21 23:33 [pubmed] PHST- 2026/09/21 20:54 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - bmjopen-2026-120638 [pii] AID - 10.1136/bmjopen-2026-120638 [doi] PST - epublish SO - BMJ Open. 2026 Sep 21;16(9):e120638. doi: 10.1136/bmjopen-2026-120638. PMID- 42767740 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260925 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 21 TI - Diagnostic accuracy of growth hormone stimulation tests for growth hormone deficiency following radiotherapy involving the hypothalamic-pituitary axis: protocol for a systematic review and planned meta-analysis. PG - e125247 LID - 10.1136/bmjopen-2026-125247 [doi] LID - e125247 AB - INTRODUCTION: Radiotherapy is part of the treatment for many intracranial tumours, head and neck cancers and haematological malignancies. In these cases, the hypothalamic-pituitary (HP) axis is often included within the radiation field and can be damaged as an organ at risk. As survival improves, an increasing number of patients are living with late endocrine complications, particularly growth hormone deficiency (GHD). Diagnosing GHD in this context is challenging, as much of the evidence supporting growth hormone (GH) stimulation tests comes from populations with fundamentally different disease mechanisms. We aim to conduct a systematic review, and meta-analysis where feasible, to assess the diagnostic accuracy of GH stimulation tests for diagnosing GHD in children, teenagers, young adults and adults who have received radiotherapy involving the HP axis. METHODS AND ANALYSIS: Eligible studies will include patients exposed to radiotherapy involving the HP axis, who subsequently underwent GH stimulation testing for suspected GHD. Index tests will include commonly used stimulation tests such as the insulin tolerance test, glucagon stimulation test, arginine stimulation test, clonidine stimulation test, GH-releasing hormone-arginine stimulation test and macimorelin stimulation test. Reference standards will include clinical criteria (>/=2 additional pituitary hormone deficiencies) or alternative GH stimulation tests. Searches will be conducted in MEDLINE, Embase, Cochrane Library and PubMed. Two independent reviewers will screen studies, collect data, evaluate risk of bias using Quality Assessment of Diagnostic Accuracy Studies-2 and assess reporting quality using the Standards for Reporting of Diagnostic Accuracy Studies criteria. Sensitivity and specificity will be extracted. Where studies are sufficiently comparable, results will be pooled using hierarchical bivariate and summary receiver operating characteristic models. Prespecified subgroup analyses will explore heterogeneity by age group, body mass index, ethnicity, radiotherapy dose and time since treatment. ETHICS AND DISSEMINATION: Ethical approval is not required as this systematic review summarises published data only. We will share our findings through peer-reviewed publications, conference presentations and engagement with relevant clinical teams to improve diagnostic decision-making in our population of interest. PROSPERO REGISTRATION NUMBER: CRD420261415689. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Chen, Lillian Ruiheng AU - Chen LR AUID- ORCID: 0009-0008-7983-1865 AD - Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK lillian.chen@nhs.net. FAU - Perry, Melissa Betty AU - Perry MB AD - Christie Patient Centred Research, The Christie NHS Foundation Trust, Manchester, UK. FAU - Salomon Estebanez, Maria AU - Salomon Estebanez M AD - Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK. FAU - Livesey, Daniel AU - Livesey D AD - The Christie Institute for Cancer Education, The Christie NHS Foundation Trust, Manchester, UK. FAU - Martin, Glen Philip AU - Martin GP AUID- ORCID: 0000-0002-3410-9472 AD - Division of Informatics, Imaging and Data Science, The University of Manchester, Manchester, UK. FAU - Higham, Claire E AU - Higham CE AD - Department of Endocrinology, The Christie Hospital NHS Trust, Manchester, UK. AD - Division of Cancer Sciences, The University of Manchester, Manchester, UK. AD - Manchester Biomedical Research Centre (BRC), NIHR, Manchester, UK. LA - eng PT - Journal Article DEP - 20260921 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 12629-01-5 (Human Growth Hormone) SB - IM MH - Humans MH - Systematic Reviews as Topic MH - *Hypothalamo-Hypophyseal System/radiation effects MH - Meta-Analysis as Topic MH - *Human Growth Hormone/deficiency MH - *Radiotherapy/adverse effects MH - Research Design PMC - PMC13599972 OTO - NOTNLM OT - Cancer Survivors OT - Diabetes & endocrinology OT - Pituitary disorders OT - RADIOTHERAPY OT - Sensitivity and Specificity OT - Systematic Review COIS- Competing interests: None declared. EDAT- 2026/09/21 23:33 MHDA- 2026/09/21 23:34 PMCR- 2026/09/21 CRDT- 2026/09/21 20:54 PHST- 2026/09/21 23:34 [medline] PHST- 2026/09/21 23:33 [pubmed] PHST- 2026/09/21 20:54 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - bmjopen-2026-125247 [pii] AID - 10.1136/bmjopen-2026-125247 [doi] PST - epublish SO - BMJ Open. 2026 Sep 21;16(9):e125247. doi: 10.1136/bmjopen-2026-125247. PMID- 42766906 OWN - NLM STAT- Publisher LR - 20260921 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 91 DP - 2026 Sep 21 TI - Facilitating participation and child-centered care: co-designing narrative and play-based communication tools for young children with type 1 diabetes. PG - 814-828 LID - S0882-5963(26)00455-0 [pii] LID - 10.1016/j.pedn.2026.09.006 [doi] AB - PURPOSE: Young children with type 1 diabetes are often marginalized in clinical consultations due to communication practices that favor verbal, adult-centered interaction. Developmentally attuned methods to support young children's meaningful participation in routine diabetes care remain limited. This study aimed to develop and examine Child-Centered Narrative Play Tools (CNPTs) and explore how they support participation, communication, expression of agency, and assess their feasibility in pediatric diabetes consultations. DESIGN AND METHODS: An iterative participatory qualitative design was conducted across two specialist pediatric diabetes clinics in Denmark. Twenty-nine children aged 3-7 years, 29 caregivers, and 12 healthcare professionals participated in workshops, exploratory testing, video-recorded clinical observations, and semi-structured interviews. Narrative story stems and play materials were co-developed and refined through cycles of testing and feedback. Data were analyzed using thematic analysis, combining inductive coding with theory-informed interpretation. RESULTS: Narrative play functioned as a primary medium through which young children expressed experiences, demonstrated understanding of diabetes management, and exercised agency during consultations. The tools enabled children to articulate everyday experiences of diabetes management and emotional responses that were often not expressed in standard consultations. Healthcare professionals reported increased confidence in communicating at the child's developmental level, and caregivers observed greater ownership and recall of consultation content. Feasibility testing indicated that the tools were feasible for routine clinical practice, with high acceptability and good usability following appropriate training. PRACTICE IMPLICATIONS: Child-Centered Narrative Play Tools (CNPTs) offer pediatric HCPs a feasible, theory-informed framework to operationalize child-centered care and make young children's perspectives visible and actionable in routine diabetes practice. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - DeCosta, Patricia AU - DeCosta P AD - Department of Prevention, Health Promotion & Community Care, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: patricia.decosta@regionh.dk. FAU - Madsen, Mette AU - Madsen M AD - Department of Pediatrics and Adolescent Medicine, Aalborg University Hospital, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. FAU - Hasselbalch, Line Aagaard AU - Hasselbalch LA AD - Department of Pediatrics and Adolescent Medicine, Aalborg University Hospital, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark. FAU - Vedel, Lotte Dyrmann AU - Vedel LD AD - Department of Pediatrics and Adolescent Medicine, Aalborg University Hospital, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark. FAU - Knudsen, Jeanette AU - Knudsen J AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Aistrup, Malene Ofjord AU - Aistrup MO AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Matthews, Maja AU - Matthews M AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Petersen, Ina Ehlers AU - Petersen IE AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Pilgaard, Kasper Ascanius AU - Pilgaard KA AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pediatrics, Herlev Hospital, Denmark. FAU - Hagstrom, Soren AU - Hagstrom S AD - Department of Pediatrics and Adolescent Medicine, Aalborg University Hospital, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. FAU - Ejskjaer, Niels AU - Ejskjaer N AD - Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Endocrinology, Aalborg University Hospital, Denmark. FAU - Grabowski, Dan AU - Grabowski D AD - Department of Prevention, Health Promotion & Community Care, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; Department of Public Health, University of Southern Denmark, Odense, Denmark. LA - eng PT - Journal Article DEP - 20260921 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM OTO - NOTNLM OT - Diabetes mellitus, type 1 OT - Health communication OT - Patient participation OT - Pediatric nursing OT - Qualitative research COIS- Declaration of competing interest The authors declare that they have no known financial or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/21 23:33 MHDA- 2026/09/21 23:33 CRDT- 2026/09/21 18:01 PHST- 2026/02/23 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/21 23:33 [medline] PHST- 2026/09/21 23:33 [pubmed] PHST- 2026/09/21 18:01 [entrez] AID - S0882-5963(26)00455-0 [pii] AID - 10.1016/j.pedn.2026.09.006 [doi] PST - aheadofprint SO - J Pediatr Nurs. 2026 Sep 21;91:814-828. doi: 10.1016/j.pedn.2026.09.006. PMID- 42766798 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260921 LR - 20260923 IS - 2369-2529 (Print) IS - 2369-2529 (Electronic) IS - 2369-2529 (Linking) VI - 13 DP - 2026 Sep 21 TI - Delivering Virtual Group Interventions for Youth With Persisting Symptoms After Concussion (Move&Connect-Youth) and Their Caregivers (Move&Connect-Caregivers): Fidelity and Engagement Evaluation. PG - e88771 LID - 10.2196/88771 [doi] LID - e88771 AB - BACKGROUND: Youth with persisting symptoms after concussion (PSaC) can experience ongoing physical, cognitive, and emotional challenges, and their caregivers experience increased stress. There are currently limited interventions that support youth with PSaC or their caregivers. Move&Connect is a virtual group program with 2 parallel interventions: Move&Connect-Youth (M&C-Y) and Move&Connect-Caregivers (M&C-C). M&C-Y includes concussion education, active rehabilitation, and goal setting. M&C-C uses psychoeducation and practical tools to promote family communication and problem solving. OBJECTIVE: Within the context of a broader pilot study of M&C-Y and M&C-C, we completed a fidelity and engagement evaluation with the objectives of (1) evaluating intervention fidelity and (2) exploring facilitators and barriers to youth and caregiver engagement. METHODS: M&C-Y and M&C-C were delivered virtually using Zoom Healthcare and ran in parallel. Youth with PSaC and caregivers were recruited from a children's rehabilitation hospital in Ontario, Canada. Intervention fidelity was evaluated according to the 5 principles of fidelity from Bellg et al: design, training, delivery, receipt, and enactment. Intervention delivery, attendance, and engagement ratings were monitored through weekly logs and field notes. Participants completed exit satisfaction surveys, and a subset of youth and caregivers completed semistructured interviews to understand facilitators and barriers to engagement. Descriptive statistics were used to analyze logs and surveys. Directed content analysis, guided by a motivational framework, and inductive coding to identify barriers and facilitators to engagement were applied to qualitative data. RESULTS: A total of 34 youth (age: mean 15.1, SD 2.28 years) and 36 caregivers (age: mean 48.9, SD 5.92 years) participated in 10 M&C-Y and 9 M&C-C groups, respectively. Most youth identified as girls (24/34, 71%), and most caregivers identified as mothers (30/36, 83%). Clinician facilitators adhered to the components of the intervention protocols between 92% and 97% of the time in M&C-Y and 82% and 93% of the time in M&C-C. The majority of youth (22/34, 65%) and caregivers (24/36, 67%) attended 5 or more sessions. In addition, 82% (28/34) of youth and 94% (34/36) of caregivers agreed they would recommend the interventions to others. Qualitative findings revealed youth engagement was supported by motivation, comfort in the virtual setting, interactive intervention components, feelings of trust, and diverse and modifiable exercises. Barriers to youth engagement included ongoing symptoms, discrepancies between exercises and physical abilities, and previous knowledge of education. Caregiver engagement was facilitated by perceived benefits of M&C-C, emotional connection and validation, and comfort and convenience of the virtual setting. Barriers to caregiver engagement included stress, competing scheduling demands, and limited reminders or access to intervention materials. CONCLUSIONS: The pilot study of M&C-Y and M&C-C was conducted with high delivery adherence. Exit satisfaction surveys combined with qualitative data revealed high levels of caregiver satisfaction and engagement, whereas youth satisfaction and engagement had some variability, particularly related to the exercise. Findings demonstrate important implications for delivering virtual group interventions for youth with PSaC and their caregivers. CI - (c) Andrea Hickling, Hiba Al-Hakeem, Andrew Lovell, Sophie Madge-Nyren, Kylie D Mallory, Jennifer L Ryan, Christine F Provvidenza, Ruth Wilcock, Patricia Knapp, Brenda Knapp, Shari L Wade, Keith Owen Yeates, Shannon E Scratch. Originally published in JMIR Rehabilitation and Assistive Technology (https://rehab.jmir.org). FAU - Hickling, Andrea AU - Hickling A AUID- ORCID: 0000-0001-6251-6369 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. AD - Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada. FAU - Al-Hakeem, Hiba AU - Al-Hakeem H AUID- ORCID: 0000-0001-8290-5943 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. AD - Department of Psychology, University of Windsor, Windsor, ON, Canada. FAU - Lovell, Andrew AU - Lovell A AUID- ORCID: 0000-0001-9985-0432 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Madge-Nyren, Sophie AU - Madge-Nyren S AUID- ORCID: 0009-0005-7508-3108 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Mallory, Kylie D AU - Mallory KD AUID- ORCID: 0009-0005-6608-378X AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. AD - Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada. FAU - Ryan, Jennifer L AU - Ryan JL AUID- ORCID: 0000-0001-7516-9562 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Provvidenza, Christine F AU - Provvidenza CF AUID- ORCID: 0000-0002-1741-239X AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Wilcock, Ruth AU - Wilcock R AUID- ORCID: 0009-0008-7429-6576 AD - Ontario Brain Injury Association, Thorold, ON, Canada. FAU - Knapp, Patricia AU - Knapp P AUID- ORCID: 0009-0004-4697-422X AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Knapp, Brenda AU - Knapp B AUID- ORCID: 0009-0002-5022-9041 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Wade, Shari L AU - Wade SL AUID- ORCID: 0000-0003-3764-7126 AD - Division of Rehabilitation Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. AD - Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States. FAU - Yeates, Keith Owen AU - Yeates KO AUID- ORCID: 0000-0001-7680-2892 AD - Department of Psychology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. FAU - Scratch, Shannon E AU - Scratch SE AUID- ORCID: 0000-0001-9191-2571 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. AD - Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. LA - eng PT - Journal Article DEP - 20260921 PL - Canada TA - JMIR Rehabil Assist Technol JT - JMIR rehabilitation and assistive technologies JID - 101703412 PMC - PMC13592660 OTO - NOTNLM OT - brain injury OT - concussion OT - group intervention OT - parents OT - pediatrics OT - qualitative OT - rehabilitation OT - telehealth OT - telemedicine OT - virtual care COIS- Conflicts of Interest: None declared. EDAT- 2026/09/21 17:47 MHDA- 2026/09/21 17:48 PMCR- 2026/09/21 CRDT- 2026/09/21 15:52 PHST- 2025/12/01 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/21 17:48 [medline] PHST- 2026/09/21 17:47 [pubmed] PHST- 2026/09/21 15:52 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - v13i1e88771 [pii] AID - 88771 [pii] AID - 10.2196/88771 [doi] PST - epublish SO - JMIR Rehabil Assist Technol. 2026 Sep 21;13:e88771. doi: 10.2196/88771. PMID- 42766722 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260921 LR - 20260923 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Sep 21 TI - Generative AI Engagement and Perceived Nutrition-Oriented Feeding Practices Among Urban Indonesian Mothers: Mixed Methods Study. PG - e100061 LID - 10.2196/100061 [doi] LID - e100061 AB - BACKGROUND: The Asia-Pacific region faces an escalating double burden of malnutrition, with childhood obesity now affecting more than 113 million children aged 0-19 years. A demographic of highly educated, digitally literate urban mothers-referred to in this study using the descriptive label "Alpha Mother"-increasingly draws on generative AI as a source of toddler nutrition information. Yet, whether this shift empowers or undermines quality feeding practices remains empirically untested. OBJECTIVE: This study examined how generative artificial intelligence (AI) engagement is associated with perceived nutrition-oriented feeding practices among urban Alpha Mothers in Indonesia, with cognitive empowerment and parental self-compassion as intervening variables, and eHealth self-efficacy as a moderator. The study contextually refined 5 AI engagement dimensions, organized through an AI parenting nutrition alignment approach. METHODS: An exploratory sequential mixed methods design was used. Phase 1 comprised semistructured interviews with 10 Alpha Mothers and used hybrid deductive-inductive thematic analysis to contextually refine 5 literature-informed AI engagement constructs: AI algorithmic trust, AI health information quality, AI personalization fit perception, AI information-seeking intensity, and AI social proof sensitivity. These informed a survey instrument developed through the qualitative phase and refined against previously validated scales in phase 2, recruiting 442 respondents across 4 Indonesian urban centers. A 14-hypothesis structural model was tested using PLS-SEM (partial least squares-structural equation modeling). RESULTS: Twelve of 14 hypotheses were supported. The model demonstrated substantial explanatory power for cognitive empowerment (R(2)=0.661) and parental self-compassion (R(2)=0.719), while perceived nutrition-oriented feeding practices yielded a more modest value (R(2)=0.280). This result reflects the multifactorial nature of self-reported nutrition-oriented feeding practices, which is shaped by numerous personal, cultural, and situational factors beyond AI engagement. AI algorithmic trust showed the strongest association with parental self-compassion (beta=.479; P<.001), while AI personalization fit perception most strongly predicted cognitive empowerment (beta=.275; P<.001). Both intervening variables were significantly associated with nutrition-oriented feeding practices, with cognitive empowerment (beta=.232; P=.003) outperforming parental self-compassion (beta=.165; P=.009). eHealth self-efficacy moderated the cognitive empowerment pathway (beta=.124; P=.02) but not the self-compassion pathway. CONCLUSIONS: The findings suggest that generative AI engagement is associated with perceived nutrition-oriented feeding practices via 2 distinct indirect associations examined in this study: cognitive empowerment and parental self-compassion. These associations were strongest when mothers trusted the AI system and perceived its recommendations as fitting their child and household realities, indicating that the perceived value of AI in toddler feeding may lie less in algorithmic sophistication than in its capacity to build trust, fit context, and support maternal judgment. Because the outcome reflects maternal perception rather than observed feeding behavior or child nutrition outcomes, these findings should be interpreted as associational. They may nonetheless inform future research on AI-assisted feeding support that complements, rather than replaces, professional nutrition counseling. CI - (c) Lia Nur Amalina, Ferdi Antonio, Surya Adiwena, Dewi Wuisan, Roy Glenn Massie. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Amalina, Lia Nur AU - Amalina LN AUID- ORCID: 0009-0002-8791-4632 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Antonio, Ferdi AU - Antonio F AUID- ORCID: 0000-0002-1319-3732 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Adiwena, Surya AU - Adiwena S AUID- ORCID: 0009-0005-0198-4341 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Wuisan, Dewi AU - Wuisan D AUID- ORCID: 0000-0001-8550-3659 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Massie, Roy Glenn AU - Massie RG AUID- ORCID: 0009-0007-9980-8841 AD - Health Policy, National Research and Innovation Agency (BRIN), Jakarta, Indonesia. LA - eng PT - Journal Article DEP - 20260921 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13592562 OTO - NOTNLM OT - Indonesia OT - cognitive empowerment OT - feeding behavior OT - generative artificial intelligence OT - health literacy OT - mothers OT - parental self-compassion OT - parenting OT - self-efficacy COIS- Conflicts of Interest: None declared. EDAT- 2026/09/21 17:47 MHDA- 2026/09/21 17:48 PMCR- 2026/09/21 CRDT- 2026/09/21 14:43 PHST- 2026/05/02 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/21 17:48 [medline] PHST- 2026/09/21 17:47 [pubmed] PHST- 2026/09/21 14:43 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - v9i1e100061 [pii] AID - 100061 [pii] AID - 10.2196/100061 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Sep 21;9:e100061. doi: 10.2196/100061. PMID- 42766014 OWN - NLM STAT- Publisher LR - 20260921 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) DP - 2026 Sep 21 TI - Results of the validated German Perceived Stress Questionnaire (PSQ) from a large German cohort of healthy adults and different disease groups compared to historical reference values. LID - 10.1007/s00406-026-02379-8 [doi] AB - BACKGROUND: Reference values of the validated German Perceived Stress Questionnaire (PSQ) were published in 2005 for healthy adults and individuals with different clinical conditions. We compared historical values with PSQ from the large German cohort participating in "Risk Factors for COVID-19 Vaccine Failure study (RisCoin). METHODS: In late 2021, we enrolled 4115 adults: hospital employees or patients with inflammatory bowel disease (IBD) or psychiatric disorders with >/= 2 COVID-19 vaccinations. Participants completed extensive questionnaires including PSQ. Healthcare workers (HCW) were categorized as HCW-healthy or HCW-plus (any chronic medical condition). PSQ total and domain scores (worries, tension, joy, demands) were compared to reference values. Multivariable logistic regression identified factors associated with cohort-specific high scores (mean + 1SD). RESULTS: HCW-healthy (N = 1998, mean age +/- SD: 38 +/- 12 years) reached higher mean total PSQ scores than historical healthy individuals (36 +/- 18 vs. 33 +/- 17, respectively, p<0.001), but lower scores (40 +/- 19, p < 0.001) than HCW-plus (N = 1717, 43 +/- 13 years). Female HCW-healthy perceived higher stress than males, especially at younger age. Participants with IBD (N = 161, 45 +/- 15 years) exhibited lower scores than historical IBD patients (38 +/- 19 vs. 43 +/- 17, p < 0.001); psychiatric patients (N = 100, 41 +/- 15 years) showed the highest scores (60 +/- 19). Among HCW, female gender, frequent consumption of ready-to-eat meals/foods, and living with children were associated with higher, whereas regular physical activity and healthy dietary habits with lower PSQ scores. CONCLUSION: Assuming representativeness of our cohort, these PSQ data could serve as updated benchmark for future research. CI - (c) 2026. The Author(s). FAU - Adorjan, Kristina AU - Adorjan K AD - Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Center for International Health (CIH), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - University Hospital of Psychiatry and Psychotherapy (UPZ), University of Bern, Bern, Switzerland. FAU - Raffel, Jannis AU - Raffel J AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Zhelyazkova, Ana AU - Zhelyazkova A AUID- ORCID: 0000-0002-8085-5003 AD - Institut fur Notfallmedizin und Medizinmanagement (INM), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Csollarova, Katarina AU - Csollarova K AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Jebrini, Tarek AU - Jebrini T AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Wratil, Paul R AU - Wratil PR AUID- ORCID: 0000-0003-0942-0637 AD - Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Keppler, Oliver T AU - Keppler OT AD - Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Tuschen, Marina AU - Tuschen M AD - Department of Anaesthesiology, Laboratory of Translational Research Stress and Immunity,LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Koletzko, Leandra AU - Koletzko L AD - Department of Medicine II, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Torok, Helga P AU - Torok HP AD - Department of Medicine II, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Chouker, Alexander AU - Chouker A AD - Department of Anaesthesiology, Laboratory of Translational Research Stress and Immunity,LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Koletzko, Sibylle AU - Koletzko S AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. Sibylle.Koletzko@med.uni-muenchen.de. AD - Department of Pediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland. Sibylle.Koletzko@med.uni-muenchen.de. FAU - Le Thi, Thu Giang AU - Le Thi TG AUID- ORCID: 0000-0002-2504-9551 AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. thu_giang.le_thi@med.uni-muenchen.de. AD - Stiftung Kindergesundheit, c/o Dr. von Hauner Children's Hospital, LMU University Hospital, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. thu_giang.le_thi@med.uni-muenchen.de. CN - Members of RisCoin Study Group LA - eng PT - Journal Article DEP - 20260921 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 SB - IM OTO - NOTNLM OT - Chronic conditions OT - Collaborative care OT - Prospective study OT - Risk factors OT - Stress COIS- Declarations. Conflict of interest: The authors declare no competing interests. Informed consent statement: All the participants provided written informed consent prior to participation. Institutional review board statement: This study protocol was approved by the Ethics Committee of LMU Munich on September 21, 2021 (Project Number: 21-0839), with acceptance of amendments on February 22, 2022, and May 4, 2022. The data protection concept was approved by the LMU data protection officer on September 15, 2021, and the amendment for the second follow-up was approved on September 8, 2022. Clinical trial registration: "Risk factors for COVID-19 vaccine failure, "RisCoin", MainID: DRKS00026804, http://drks.de/search/en/trial/DRKS00026804 (Accessed on 18.07.2025). FIR - Osterman, A IR - Osterman A FIR - Badell Garcia, I IR - Badell Garcia I FIR - Huber, M IR - Huber M FIR - Wratil, P R IR - Wratil PR FIR - Adorjan, K IR - Adorjan K FIR - Gryaznova, A IR - Gryaznova A FIR - Jebrini, T IR - Jebrini T FIR - Kohl, P IR - Kohl P FIR - Jonge, S IR - Jonge S FIR - Neumeier, K IR - Neumeier K FIR - Koletzko, S IR - Koletzko S FIR - Koletzko, B IR - Koletzko B FIR - Kim-Helmuth, S IR - Kim-Helmuth S FIR - Hao, Y IR - Hao Y FIR - Horak, J IR - Horak J FIR - Le Thi, T G IR - Le Thi TG FIR - Puzek, B IR - Puzek B FIR - Schwerd, T IR - Schwerd T FIR - Torok, H P IR - Torok HP FIR - Koletzko, L IR - Koletzko L FIR - Breiteneicher, S IR - Breiteneicher S FIR - Csollarova, K IR - Csollarova K FIR - Chouker, A IR - Chouker A FIR - Tuschen, M IR - Tuschen M FIR - Biere, K IR - Biere K FIR - Wohrle, T IR - Wohrle T FIR - Matzel, S IR - Matzel S FIR - Horl, M IR - Horl M FIR - Moser, D IR - Moser D FIR - Hornung, V IR - Hornung V FIR - Rech, J IR - Rech J FIR - Ludwig, C IR - Ludwig C FIR - Hansbauer, L IR - Hansbauer L FIR - Zhelyazkova, A IR - Zhelyazkova A FIR - Klein, M IR - Klein M FIR - Volk, S IR - Volk S EDAT- 2026/09/21 17:47 MHDA- 2026/09/21 17:47 CRDT- 2026/09/21 11:04 PHST- 2026/03/26 00:00 [received] PHST- 2026/09/06 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/09/21 17:47 [pubmed] PHST- 2026/09/21 11:04 [entrez] AID - 10.1007/s00406-026-02379-8 [pii] AID - 10.1007/s00406-026-02379-8 [doi] PST - aheadofprint SO - Eur Arch Psychiatry Clin Neurosci. 2026 Sep 21. doi: 10.1007/s00406-026-02379-8. PMID- 42765914 OWN - NLM STAT- Publisher LR - 20260921 IS - 1558-9129 (Electronic) IS - 0161-1461 (Linking) DP - 2026 Sep 21 TI - Children's Rights to the Best Possible Care: Establishing Processes for Data Collection in Routine Care to Address Questions of Intervention Effectiveness for Children With Speech Sound Disorder. PG - 1-10 LID - 10.1044/2026_LSHSS-25-00202 [doi] AB - PURPOSE: The United Nations Convention of the Rights of the Child (CRC) recognizes that all children have a right to the best possible care, CRC Article 24 (health, water, food, environment). For children with speech sound disorder, this is vital in order to protect their rights to CRC Article 13 (sharing thoughts freely), CRC Article 19 (protection from violence), and CRC Article 28 (access to education). Determining what constitutes best possible care for this population is challenging because much evidence for intervention takes place outside of routine care. This review article provides an overview of Phase 1 of the Maximising the Impact of Speech and Language Therapy for Children with Speech Sound Disorder (MISLToe_SSD) program of research, which ultimately aims to establish a process for using data collected in routine care to investigate best possible care for children with speech sound disorder. The purpose of Phase 1 was to obtain consensus on a diagnostic pathway, a defined list of interventions, and a core outcome set. METHOD AND RESULTS: An umbrella review was carried out to provide information on existing evidence. Participatory workshops with speech and language therapists were used to determine the content of the diagnostic pathway, and a card sorting exercise was used to provide a list of interventions currently in use and agree on their definitions. Finally, the core outcome set was agreed through a Delphi process. Patient and public involvement activities were used throughout the program of work to ensure that the aims and activities were in line with the preferences of those with lived experience of speech sound disorder. CONCLUSIONS: Consensus was reached on the three core aims of agreeing a diagnostic protocol, a core outcome set, and a list of defined interventions. Phase 2 of MISLToe_SSD will establish the feasibility of implementing these within routine care, and Phase 3 will extend the work to multiple services, leading to the large data set required for future analyses. This work has been carried out in the United Kingdom, but work is underway to replicate this work in Brazil, Sweden, Portugal, and other countries and in other languages to establish an international diagnostic pathway, a defined list of interventions, and a core outcome set. FAU - Wren, Yvonne AU - Wren Y AUID- ORCID: 0000-0002-1575-453X AD - Bristol Speech & Language Therapy Research Unit, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom. AD - Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Llandaff Campus, Wales, United Kingdom. AD - Bristol Dental School, University of Bristol, United Kingdom. FAU - Burr, Sam AU - Burr S AD - Bristol Speech & Language Therapy Research Unit, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom. AD - Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Llandaff Campus, Wales, United Kingdom. FAU - Cleland, Joanne AU - Cleland J AUID- ORCID: 0000-0002-0660-1646 AD - Department of Psychological Sciences & Health, University of Strathclyde, Glasgow, Scotland. FAU - Stringer, Helen AU - Stringer H AD - King George VI Building, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Harding, Sam AU - Harding S AD - Bristol Speech & Language Therapy Research Unit, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom. AD - Department of Research & Development, North Bristol NHS Trust, United Kingdom. LA - eng PT - Journal Article DEP - 20260921 PL - United States TA - Lang Speech Hear Serv Sch JT - Language, speech, and hearing services in schools JID - 0323431 SB - IM EDAT- 2026/09/21 11:44 MHDA- 2026/09/21 11:44 CRDT- 2026/09/21 10:23 PHST- 2026/09/21 11:44 [medline] PHST- 2026/09/21 11:44 [pubmed] PHST- 2026/09/21 10:23 [entrez] AID - 10.1044/2026_LSHSS-25-00202 [doi] PST - aheadofprint SO - Lang Speech Hear Serv Sch. 2026 Sep 21:1-10. doi: 10.1044/2026_LSHSS-25-00202. PMID- 42765528 OWN - NLM STAT- Publisher LR - 20261014 IS - 1744-8379 (Electronic) IS - 1473-7167 (Print) IS - 1473-7167 (Linking) DP - 2026 Sep 22 TI - Obstetric pharmacoeconomics. PG - 1-16 LID - 10.1080/14737167.2026.2738026 [doi] AB - INTRODUCTION: Pharmacoeconomic principles are increasingly shaping modern obstetric pharmacology as maternal therapeutics become more complex, costly, and precision-driven. Rising rates of hypertensive disorders of pregnancy, gestational diabetes, obesity, maternal cardiovascular disease, and medically complicated pregnancies have intensified the need for cost-effective therapeutic strategies that optimize maternal and neonatal outcomes while minimizing unnecessary healthcare expenditure. AREAS COVERED: This review examines contemporary pharmacoeconomic concepts in obstetric pharmacology, including cost-effectiveness analysis, quality-adjusted life years, implementation science, and value-based maternal therapeutics. Major domains reviewed include antihypertensive therapy, aspirin prophylaxis, diabetes pharmacotherapy, antiretroviral therapy in pregnancy, anticoagulation, perinatal mental health, lactation, fetal therapeutics, pharmacogenomics, precision dosing, digital health integration, and emerging artificial intelligence applications in maternal fetal medicine. The review further explores linked maternal-child outcome modeling, implementation-sensitive economic evaluation, and the growing role of pharmacometrics and biomarker-guided therapeutics in precision pregnancy care. The review also proposes a life-course framework linking pregnancy therapeutics to inter-generational health, implementation outcomes, and sustainable maternal healthcare systems globally. EXPERT OPINION: Obstetric pharmacology is entering a precision-medicine era where therapeutic value will depend on biologic profiling, implementation feasibility, and long-term maternal-child outcomes. Future pharmacoeconomic frameworks should integrate precision therapeutics, biomarker-guided strategies, real-world effectiveness, and lifelong maternal cardiovascular risk reduction. FAU - Eke, Ahizechukwu C AU - Eke AC AUID- ORCID: 0000-0002-0070-9840 AD - Division of Maternal Fetal-Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. AD - Masters in Business Administration (MBA Program in Healthcare Administration), Department of Business Administration, University of South Carolina, Aiken, CA, USA. FAU - Igbodike, Emeka P AU - Igbodike EP AD - Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital (LUTH), Lagos, Nigeria. LA - eng GR - DP1 HD115433/HD/NICHD NIH HHS/United States GR - R01 HL182418/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Review DEP - 20260922 PL - England TA - Expert Rev Pharmacoecon Outcomes Res JT - Expert review of pharmacoeconomics & outcomes research JID - 101132257 SB - IM PMC - PMC13657845 MID - NIHMS2212086 OTO - NOTNLM OT - Pharmacoeconomics OT - cost-effectiveness OT - drug safety OT - implementation science OT - maternal-fetal medicine OT - obstetric pharmacology OT - precision medicine OT - pregnancy COIS- Declaration of interests The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. The authors declare that OpenAI ChatGPT (GPT-5.6 Sol) was used solely to assist with editing the presentation of our original figures. Generative AI was not used to write or edit the manuscript or to generate the figures. The authors independently reviewed and verified all AI-assisted figure edits and take full responsibility for the final content. All use of generative AI was conducted in accordance with Taylor & Francis' policy on the responsible use of generative AI. EDAT- 2026/09/21 11:44 MHDA- 2026/09/21 11:44 PMCR- 2026/10/13 CRDT- 2026/09/21 07:14 PHST- 2026/09/21 11:44 [pubmed] PHST- 2026/09/21 11:44 [medline] PHST- 2026/09/21 07:14 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - 10.1080/14737167.2026.2738026 [doi] PST - aheadofprint SO - Expert Rev Pharmacoecon Outcomes Res. 2026 Sep 22:1-16. doi: 10.1080/14737167.2026.2738026. PMID- 42764933 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260921 LR - 20260922 IS - 2211-3355 (Print) IS - 2211-3355 (Electronic) IS - 2211-3355 (Linking) VI - 71 DP - 2026 Nov TI - Analysis of the current status and correlates of knowledge-attitude-practice (KAP) regarding cardiovascular and cerebrovascular diseases (CCVD) in adolescents and young adults. PG - 103615 LID - 10.1016/j.pmedr.2026.103615 [doi] LID - 103615 AB - OBJECTIVE: To investigate knowledge-attitude-practice (KAP) regarding cardiovascular and cerebrovascular diseases (CCVD) among adolescents and young adults, and to identify associated factors to provide evidence for targeted prevention. METHODS: A cross-sectional survey was conducted through digital platforms from August to October 2025, recruiting 636 participants from North, East and Southwest China through convenience sampling. Data were collected via a self-designed CCVD KAP questionnaire, S-CVI was 0.93, and Cronbach's alpha was 0.92. The data were analyzed using SPSS 27.0. RESULTS: The overall KAP score was (74.90 +/- 20.83), with a scoring rate 63.47%. Among the three dimensions, the attitude subscale scored the highest, followed by knowledge and practice. Multiple linear regression analysis showed that the total score positively correlated with female gender, better self-rated health, and overweight; negatively with East and Southwest China residence, higher-maternal education, and unknown family history. For knowledge and attitude, exercise and sleep were positively correlated, smoking and drinking negatively. Higher education positively correlated with knowledge and attitude but negatively with practice. CONCLUSION: Awareness of CCVD was moderate, with positive attitude but suboptimal behavioral adherence. These findings support targeted interventions to address the knowledge-practice gap, particularly among those with low education, unhealthy lifestyles, or uncertain family history. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Sun, Tongyan AU - Sun T AD - School of Nursing, Tianjin Medical University, Tianjin 300070, China. FAU - Zhang, Hua AU - Zhang H AD - School of Nursing, Tianjin Medical University, Tianjin 300070, China. LA - eng PT - Journal Article DEP - 20260910 PL - United States TA - Prev Med Rep JT - Preventive medicine reports JID - 101643766 PMC - PMC13590049 OTO - NOTNLM OT - Adolescents OT - Cardiovascular and cerebrovascular diseases (CCVD) OT - Knowledge-attitude-practice (KAP) OT - Young adults COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/21 05:34 MHDA- 2026/09/21 05:35 PMCR- 2026/09/10 CRDT- 2026/09/21 03:42 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/26 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/21 05:35 [medline] PHST- 2026/09/21 05:34 [pubmed] PHST- 2026/09/21 03:42 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - S2211-3355(26)00243-3 [pii] AID - 103615 [pii] AID - 10.1016/j.pmedr.2026.103615 [doi] PST - epublish SO - Prev Med Rep. 2026 Sep 10;71:103615. doi: 10.1016/j.pmedr.2026.103615. eCollection 2026 Nov. PMID- 42764707 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260923 IS - 1520-6300 (Electronic) IS - 1042-0533 (Print) IS - 1042-0533 (Linking) VI - 38 IP - 9 DP - 2026 Sep TI - Sleep Duration and Sun Exposure in Portuguese Children: Associations With Obesity Indicators. PG - e70333 LID - 10.1002/ajhb.70333 [doi] LID - e70333 AB - INTRODUCTION: Sleep duration, sun exposure, and obesity are important and potentially interconnected factors in child health. In this study, we aimed to analyze the associations between sleep duration, sun exposure, and obesity indicators in Portuguese children. METHODS: This cross-sectional study included 4755 children aged 3-10 years from public and private schools across Portugal. Parents reported children's sleep duration, sun exposure, screen time, active play, and physical activity using validated questionnaires. Trained professionals measured weight and height to calculate Body Mass Index (BMI) and assessed skinfold thickness to estimate body fat percentage (%BF). Multiple linear regression analyses, stratified by sex and adjusted for demographic, behavioral, and anthropometric factors, analyzed associations between sun exposure and sleep duration. RESULTS: In partially adjusted models (Model 1), negative associations persisted among boys, and positive associations emerged in girls for average sleep duration (beta = 2.11; 95% CI: 0.25 to 3.96; p = 0.026) and weekdays (beta = 2.40; 95% CI: 0.47 to 4.33; p = 0.015). In fully adjusted models (Model 2), the negative association remained only for boys on Sundays (beta = -4.57; 95% CI: -8.22 to -0.91; p = 0.014), with no significant associations in girls. CONCLUSIONS: Sun exposure exhibits modest, sex-specific associations with sleep duration in children. These findings emphasize the importance of considering behavioral and environmental factors when designing interventions to promote healthy sleep, support growth, and prevent childhood obesity. CI - (c) 2026 The Author(s). American Journal of Human Biology published by Wiley Periodicals LLC. FAU - Dos Santos, Elizabete A AU - Dos Santos EA AUID- ORCID: 0000-0001-9201-4095 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - Department of Nutrition, Paulista School of Medicine (EPM) of the Federal University of Sao Paulo (Unifesp), Sao Paulo, Brazil. FAU - Machado-Rodrigues, Aristides AU - Machado-Rodrigues A AUID- ORCID: 0000-0002-7169-8034 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - Faculty of Sport Sciences and Physical Education, University of Coimbra, Coimbra, Portugal. FAU - Rodrigues, Daniela AU - Rodrigues D AUID- ORCID: 0000-0002-4559-4303 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. FAU - Silva, Maria-Raquel G AU - Silva MG AUID- ORCID: 0000-0001-8170-3119 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - FP-I3ID, FP-BHS, CEBIMED and Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal. AD - Comprehensive Health Research Centre, Nova Medical School, Nova University of Lisbon, Lisbon, Portugal. FAU - Nogueira, Helena AU - Nogueira H AUID- ORCID: 0000-0001-5724-3538 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - Department of Geography and Tourism, University of Coimbra, Coimbra, Portugal. FAU - Padez, Cristina AU - Padez C AUID- ORCID: 0000-0002-1967-3497 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. LA - eng GR - PTDC/DTP-SAP/1520/2014/Fundacao para a Ciencia e a Tecnologia/ GR - COMPETE 2020, Portugal 2020, FEDER, and FCT/ PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Portugal/epidemiology MH - *Sleep Duration MH - Male MH - Child MH - Female MH - Cross-Sectional Studies MH - Child, Preschool MH - *Sunlight MH - *Pediatric Obesity/epidemiology/etiology MH - *Sleep PMC - PMC13591200 OTO - NOTNLM OT - childhood obesity OT - children OT - pediatric public health OT - sleep duration OT - sun exposure COIS- The authors used ChatGPT (OpenAI) solely to assist with English-language editing and grammatical review. The tool was not used for data collection, data analysis, statistical procedures, interpretation of the findings, or generation of scientific conclusions. All AI-assisted revisions were critically reviewed and verified by the authors to ensure their accuracy, integrity, and consistency with the original scientific content. The authors take full responsibility for the final content of the manuscript. The authors declare no conflicts of interest. EDAT- 2026/09/21 05:34 MHDA- 2026/09/21 05:35 PMCR- 2026/09/21 CRDT- 2026/09/21 03:03 PHST- 2026/08/31 00:00 [revised] PHST- 2026/07/23 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/21 05:35 [medline] PHST- 2026/09/21 05:34 [pubmed] PHST- 2026/09/21 03:03 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - AJHB70333 [pii] AID - 10.1002/ajhb.70333 [doi] PST - ppublish SO - Am J Hum Biol. 2026 Sep;38(9):e70333. doi: 10.1002/ajhb.70333. PMID- 42764592 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260921 IS - 1520-6300 (Electronic) IS - 1042-0533 (Linking) VI - 38 IP - 9 DP - 2026 Sep TI - Comparison of External Measurement Methods of the 2D:4D Digit Ratio. PG - e70337 LID - 10.1002/ajhb.70337 [doi] AB - OBJECTIVES: External methods for measuring digit length differ in the hand surface and anatomical landmarks used, but the comparability of resulting 2D:4D ratios is unclear. This study compared 2D:4D ratios obtained using four external measurement methods and evaluated between-method differences, correlations, and reliability. METHODS: Digit lengths were measured in 231 Turkish university students (103 males, 128 females). Measurements were obtained directly with calipers from the dorsal and ventral surfaces and indirectly from photocopies and photographs. The 2D:4D ratio was calculated as second-digit length divided by fourth-digit length. Right and left hands were analyzed separately for effects of measurement method, sex, and hand side. RESULTS: Males had lower 2D:4D ratios than females for all methods and hand sides except direct dorsal measurement of the left hand. Mean ratios were lowest with direct dorsal measurement and highest with direct ventral measurement. Differences among methods were significant for both hands (p < 0.001). Between-method correlations ranged from r = 0.529-0.771 for the right hand and r = 0.440-0.776 for the left hand (all p < 0.001). Intraobserver and interobserver reliability in the pilot sample was high (ICC = 0.85-0.95). CONCLUSIONS: The 2D:4D ratio varies systematically according to the external measurement method used. Measurement protocols should therefore be reported explicitly, and absolute 2D:4D values obtained using different methods should be compared cautiously. These findings highlight the importance of standardizing measurement methods in 2D:4D research and suggest that the detection of sex differences may vary according to both the measurement method and hand side. CI - (c) 2026 Wiley Periodicals LLC. FAU - Collu, Ilknur AU - Collu I AUID- ORCID: 0000-0003-1605-6327 AD - Faculty of Medicine, Department of Anatomy, Izmir Katip Celebi University, Izmir, Turkiye. FAU - Malas, Mehmet Ali AU - Malas MA AUID- ORCID: 0000-0002-1451-0672 AD - Faculty of Medicine, Department of Anatomy, Izmir Katip Celebi University, Izmir, Turkiye. LA - eng GR - 2025-TDU-TIPF-0002/Scientific Research Projects Coordination Unit of Izmir Katip Celebi University/ PT - Comparative Study PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Male MH - Female MH - *Fingers/anatomy & histology MH - Reproducibility of Results MH - *Anthropometry/methods MH - Young Adult MH - Turkey MH - *Digit Ratios MH - Adult MH - Adolescent OTO - NOTNLM OT - 2D:4D OT - digit ratio OT - direct measurement OT - dorsal surface OT - indirect measurement OT - measurement method OT - ventral surface EDAT- 2026/09/21 05:34 MHDA- 2026/09/21 05:35 CRDT- 2026/09/21 02:24 PHST- 2026/09/09 00:00 [revised] PHST- 2026/08/11 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/21 05:35 [medline] PHST- 2026/09/21 05:34 [pubmed] PHST- 2026/09/21 02:24 [entrez] AID - 10.1002/ajhb.70337 [doi] PST - ppublish SO - Am J Hum Biol. 2026 Sep;38(9):e70337. doi: 10.1002/ajhb.70337. PMID- 42764227 OWN - NLM STAT- MEDLINE DCOM- 20260920 LR - 20260923 IS - 2045-7634 (Electronic) IS - 2045-7634 (Linking) VI - 15 IP - 9 DP - 2026 Sep TI - Development and Validation of an Interpretable Machine Learning Model for Predicting Early Pulmonary Metastasis Risk in Osteosarcoma. PG - e72209 LID - 10.1002/cam4.72209 [doi] LID - e72209 AB - INTRODUCTION: Pulmonary metastasis in high-grade conventional osteosarcoma remains a leading cause of treatment failure and mortality. Traditional monitoring methods are insufficient for early detection. This study aims to develop and validate an interpretable machine learning (ML) model using multi-dimensional data from electronic medical records (EMR) to predict the early risk of pulmonary metastasis in high-grade conventional osteosarcoma patients. METHODS: This retrospective study included data from 522 high-grade conventional osteosarcoma patients. After rigorous feature selection, 12 independent predictive factors were identified: prothrombin time (PT), international normalized ratio (INR), fibrinogen, globulin, prognostic nutritional index (PNI), eosinophil percentage, monocyte percentage, neutrophil percentage, monocyte count, maximum tumor diameter, gender, and amputation status. Eleven ML models were constructed and compared, with Shapley Additive Explanations (SHAP) analysis applied to enhance model interpretability and clinical transparency. RESULTS: The gradient boosting model exhibited superior performance, achieving an area under the curve (AUC) of 0.891 in the training set and 0.742 in the independent test set. SHAP analysis revealed that tumor maximum diameter was the most influential predictor of pulmonary metastasis risk, while inflammation and coagulation-related indicators also demonstrated significant contributions. DISCUSSION: The gradient boosting model effectively predicts the early risk of pulmonary metastasis in high-grade conventional osteosarcoma and provides interpretable risk factors. This model shows potential as a clinical decision support tool, facilitating personalized risk management and precision medicine, aiming to improve patient outcomes. CI - (c) 2026 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd. FAU - Mu, Jianhua AU - Mu J AUID- ORCID: 0000-0002-0983-4605 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wang, Yitian AU - Wang Y AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Liu, Han AU - Liu H AUID- ORCID: 0009-0002-2523-6151 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. FAU - He, Xuanhong AU - He X AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. FAU - Li, Zhuangzhuang AU - Li Z AUID- ORCID: 0009-0002-0004-5455 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. FAU - Luo, Yi AU - Luo Y AUID- ORCID: 0000-0003-4470-220X AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Zhou, Yong AU - Zhou Y AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Lu, Minxun AU - Lu M AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Tang, Fan AU - Tang F AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Min, Li AU - Min L AUID- ORCID: 0009-0006-7792-5708 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Tu, Chongqi AU - Tu C AUID- ORCID: 0000-0002-1045-9742 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. LA - eng GR - 82302690/Natural Science Foundation of China/ PT - Journal Article PT - Validation Study PL - United States TA - Cancer Med JT - Cancer medicine JID - 101595310 SB - IM MH - Humans MH - *Osteosarcoma/pathology MH - *Lung Neoplasms/secondary/diagnosis MH - Female MH - *Bone Neoplasms/pathology MH - Predictive Learning Models MH - Retrospective Studies MH - *Machine Learning MH - Male MH - Prognosis MH - Boosting Machine Learning Algorithms MH - Risk Factors MH - Adult MH - Adolescent MH - Young Adult MH - Prediction Algorithms MH - Risk Assessment PMC - PMC13590279 OTO - NOTNLM OT - EMR OT - machine learning OT - osteosarcoma OT - predictive model OT - pulmonary metastasis COIS- The authors declare no conflicts of interest. EDAT- 2026/09/20 23:34 MHDA- 2026/09/20 23:35 PMCR- 2026/09/20 CRDT- 2026/09/20 21:43 PHST- 2026/07/27 00:00 [revised] PHST- 2026/01/16 00:00 [received] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/09/20 23:35 [medline] PHST- 2026/09/20 23:34 [pubmed] PHST- 2026/09/20 21:43 [entrez] PHST- 2026/09/20 00:00 [pmc-release] AID - CAM472209 [pii] AID - 10.1002/cam4.72209 [doi] PST - ppublish SO - Cancer Med. 2026 Sep;15(9):e72209. doi: 10.1002/cam4.72209. PMID- 42763723 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260921 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Physical Activity, Exercise, and Rehabilitation in Myasthenia Gravis: A Systematic Review and Narrative Synthesis. PG - e114880 LID - 10.7759/cureus.114880 [doi] LID - e114880 AB - Myasthenia gravis causes fluctuating, fatigable weakness, creating uncertainty about physical activity and exercise. This systematic review examined habitual physical activity and sedentary behaviour, barriers and facilitators to exercise, structured exercise, respiratory muscle training, and physical rehabilitation in autoimmune myasthenia gravis. PubMed, Scopus, and Web of Science Core Collection were searched from inception to 30 July 2026, without database date or language filters; backward citation searching was completed on 1 August 2026. Primary human studies published in English were eligible if they reported a relevant measure of physical activity, a defined physical intervention, or barriers, facilitators, or professional advice as an explicit primary focus. We included randomized trials, non-randomized intervention studies, observational and qualitative studies, and case series of at least two participants. Multiple reports from the same cohort or trial were linked before synthesis. Risk of bias was assessed with tools appropriate to each design, and certainty was rated by outcome domain. Of 2,767 database records imported into EndNote (Clarivate, Philadelphia, PA), 1,946 remained after deduplication. Across database and citation searching, 66 reports were assessed in full, and 47 reports representing 38 study units (whole studies or distinct study components) were included. In several observational datasets, greater activity was associated with less fatigue or lower disease burden; however, most analyses were cross-sectional and vulnerable to confounding and reverse causality. Intervention studies were small and heterogeneous. Some secondary outcomes and results measured after treatment favoured the intervention for respiratory muscle performance, functional capacity, strength, or patient-reported outcomes, and some measures improved within groups; however, several controlled primary outcomes were null. Evidence from perioperative care, recovery after crisis or hospitalization, and paediatric populations addressed distinct clinical contexts and was not generalized to stable community-dwelling adults. Some selected cohorts achieved high completion or attendance, but reporting of adverse events was incomplete, and certainty about safety was very low. Individually adapted activity and exercise appeared feasible for many selected participants with clinically stable, predominantly mild-to-moderate disease. However, efficacy remains very uncertain, and safety has not been established across the broader myasthenia gravis population. CI - Copyright (c) 2026, Karbownik et al. FAU - Karbownik, Alicja AU - Karbownik A AD - Department of Orthopaedics and Traumatology of the Musculoskeletal System, Medical University of Warsaw, Warsaw, POL. FAU - Lis, Monika AU - Lis M AD - Department of Medicine, Mazovian "Brodnowski" Hospital, Warsaw, POL. FAU - Hejnosz, Aleksandra AU - Hejnosz A AD - Department of Medicine, Mazovian "Brodnowski" Hospital, Warsaw, POL. FAU - Szczerba, Mateusz AU - Szczerba M AD - Department of Medicine, Dr. Anna Gostynska Wolski Hospital, Warsaw, POL. FAU - Piwar, Hubert AU - Piwar H AD - Department of Medicine, Dr. Anna Gostynska Wolski Hospital, Warsaw, POL. FAU - Grodzka, Olga AU - Grodzka O AD - Doctoral School, Medical University of Warsaw, Warsaw, POL. FAU - Puziuk, Magdalena AU - Puziuk M AD - Department of Medicine, Dr. Aleksander Majkowski District Hospital, Kartuzy, POL. FAU - Mikolajczak, Pawel AU - Mikolajczak P AD - Department of Medicine, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, POL. FAU - Michalowicz, Barbara AU - Michalowicz B AD - Department of Medicine, Wladyslaw Bieganski District Hospital in Ilawa, Ilawa, POL. FAU - Cierpial, Patryk AU - Cierpial P AD - Department of Medicine, Central Clinical Hospital in Warsaw, Warsaw, POL. FAU - Rode, Katarzyna AU - Rode K AD - Department of Orthopaedics and Traumatology of the Musculoskeletal System, Medical University of Warsaw, Warsaw, POL. FAU - Staranowicz, Albert AU - Staranowicz A AD - Department of Orthopaedics and Traumatology of the Musculoskeletal System, Medical University of Warsaw, Warsaw, POL. FAU - Pawlasek, Jan AU - Pawlasek J AD - Department of Pharmacotherapy and Pharmaceutical Care, Medical University of Warsaw, Warsaw, POL. FAU - Sucharski, Mateusz AU - Sucharski M AD - Department of Medicine, Military Institute of Medicine - National Research Institute, Warsaw, POL. FAU - Dziurzynska, Martyna AU - Dziurzynska M AD - Department of Internal Medicine and Gastroenterology, Mazovian "Brodnowski" Hospital, Warsaw, POL. FAU - Dziurzynski, Patryk AU - Dziurzynski P AD - Department of Gastroenterology, Bielanski Hospital, Warsaw, POL. FAU - Niemczyk, Wiktor AU - Niemczyk W AD - Department of Medicine, Mazovian "Brodnowski" Hospital, Warsaw, POL. FAU - Garbacik, Aleksandra AU - Garbacik A AD - Department of Orthopaedics and Traumatology of the Musculoskeletal System, Medical University of Warsaw, Warsaw, POL. LA - eng PT - Journal Article PT - Review DEP - 20260820 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13589643 OTO - NOTNLM OT - breathing exercises OT - exercise therapy OT - fatigue OT - myasthenia gravis OT - quality of life OT - rehabilitation COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/08/20 CRDT- 2026/09/20 04:00 PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/20 04:00 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - 10.7759/cureus.114880 [doi] PST - epublish SO - Cureus. 2026 Aug 20;18(8):e114880. doi: 10.7759/cureus.114880. eCollection 2026 Aug. PMID- 42763700 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260921 IS - 1726-9148 (Electronic) IS - 1726-913X (Print) IS - 1726-913X (Linking) VI - 24 IP - 2 DP - 2026 Apr 30 TI - Subclinical Diastolic Indices in Children with Type 1 Diabetes: A Cross-Sectional Comparative Study from Northern Iran. PG - e164686 LID - 10.5812/ijem-164686 [doi] LID - e164686 AB - BACKGROUND: Type 1 diabetes mellitus (T(1)DM) is common and can cause cardiac complications. Subclinical myocardial involvement, particularly impaired diastolic function, is a concern in pediatric patients with T(1)DM. OBJECTIVES: This study aimed to assess cardiac function, with a particular focus on diastolic indices, in children with T(1)DM. METHODS: In this cross-sectional comparative study, children aged 6 - 12 years were divided into two groups: a case group with T(1)DM and a control group of healthy children. Participants were recruited in 2023 from the Endocrinology Clinic at Amirkola Children's Hospital, Babol, Iran. All children underwent clinical evaluation, pubertal status assessment using the Marshall-Tanner criteria, electrocardiography, and echocardiography. RESULTS: A total of 150 children were included, comprising 50 children with T(1)DM and 100 controls. Overall, 52% of the participants were boys, and the mean age was 9.28 +/- 1.85 years. Late diastolic tissue velocity (A') was significantly higher in the T(1)DM group (P = 0.02), suggesting subclinical diastolic impairment. However, most other cardiac parameters, including all systolic indices, ejection fraction, fractional shortening, and electrocardiographic findings, were comparable between the groups (all P > 0.4). The T(1)DM group also had higher mean weight, height, body mass index, and body mass index percentiles (all P < 0.05). CONCLUSIONS: Children with T(1)DM exhibited subtle diastolic dysfunction, reflected by elevated A', whereas systolic function and other cardiac parameters were comparable with those in controls. Given the cross-sectional design, limited sample size, and potential confounding by body mass index and selection bias, these findings should be interpreted cautiously. The standardized single-center methodology supports internal validity; however, multicenter longitudinal studies with larger, z-score-adjusted samples are needed to confirm these results and clarify their clinical implications. CI - Copyright (c) 2026, Rezvani et al. FAU - Rezvani, Atoosa AU - Rezvani A AUID- ORCID: 0009-0006-8083-2203 AD - Student Research Committee, Babol University of Medical Sciences, Babol, Iran. FAU - Mirzaei Ilali, Hamidreza AU - Mirzaei Ilali H AUID- ORCID: 0000-0001-5238-2811 AD - Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran. FAU - Ebrahimzade, Hadis AU - Ebrahimzade H AUID- ORCID: 0000-0003-0649-7268 AD - Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran. FAU - Gholinia Ahangar, Hemmat AU - Gholinia Ahangar H AUID- ORCID: 0000-0003-0517-2429 AD - Health Research Institute, Babol University of Medical Sciences, Babol, Iran. FAU - Aghajanpour, Faeze AU - Aghajanpour F AUID- ORCID: 0000-0002-1698-6906 AD - Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. FAU - Alijanpour, Morteza AU - Alijanpour M AUID- ORCID: 0000-0002-0031-4718 AD - Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. LA - eng PT - Journal Article DEP - 20260424 PL - Netherlands TA - Int J Endocrinol Metab JT - International journal of endocrinology and metabolism JID - 101235597 PMC - PMC13589466 OTO - NOTNLM OT - Cardiovascular Disease OT - Child OT - Echocardiography OT - Iran OT - Type 1 Diabetes Mellitus COIS- There was no conflict of interest EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/04/24 CRDT- 2026/09/20 03:59 PHST- 2025/07/21 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/20 03:59 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - 10.5812/ijem-164686 [doi] PST - epublish SO - Int J Endocrinol Metab. 2026 Apr 24;24(2):e164686. doi: 10.5812/ijem-164686. eCollection 2026 Apr 30. PMID- 42763564 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260921 IS - 2090-6803 (Print) IS - 2090-6811 (Electronic) IS - 2090-6811 (Linking) VI - 2026 DP - 2026 TI - Managing Drug-Resistant Epilepsy and Severe Feeding Difficulties in Miller-Dieker Syndrome: The Role of Enteral Ketogenic Diet. PG - 8660691 LID - 10.1155/crpe/8660691 [doi] LID - 8660691 AB - Miller-Dieker syndrome (MDS) is a rare genetic disorder characterized by classical lissencephaly, severe neurodevelopmental impairment, and early-onset drug-resistant epilepsy. Feeding difficulties and aspiration pneumonia significantly contribute to morbidity and mortality. Evidence regarding ketogenic diet (KD) therapy in patients with severe neurological impairment requiring exclusive enteral nutrition is limited. We report the case of an infant with MDS and pharmacoresistant epilepsy complicated by severe feeding intolerance and recurrent aspiration pneumonia. KD was initiated via postpyloric enteral feeding and subsequently administered through percutaneous endoscopic jejunostomy using a low ketogenic ratio (1.25:1). The diet was well tolerated and associated with seizure freedom maintained until the child's death from an unrelated surgical complication (volvulus), improved nutritional status, and several months of clinical stability. This case highlights the feasibility of enteral KD therapy as part of a multidisciplinary, palliative-oriented approach for managing drug-resistant epilepsy in children with MDS. CI - Copyright (c) 2026 Perrone Michela et al. Case Reports in Pediatrics published by John Wiley & Sons Ltd. FAU - Michela, Perrone AU - Michela P AUID- ORCID: 0000-0002-1318-7922 AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Matteo, Porro AU - Matteo P AD - Paediatric Physical Medicine & Rehabilitation Service, Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Pasqua, Piemontese AU - Pasqua P AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Paola, Roggero AU - Paola R AUID- ORCID: 0000-0003-2667-4620 AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Silvana, Gangi AU - Silvana G AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Monica, Fumagalli AU - Monica F AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. AD - Department of Clinical Sciences and Community Health Milan, University of Milan, Lombardy, Milan, Italy, unimi.it. LA - eng PT - Journal Article DEP - 20260918 PL - United States TA - Case Rep Pediatr JT - Case reports in pediatrics JID - 101581030 PMC - PMC13589161 OTO - NOTNLM OT - developmental disability OT - ketogenic diet OT - pediatric OT - seizures COIS- The authors declare no conflicts of interest. EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/09/18 CRDT- 2026/09/20 03:52 PHST- 2026/03/12 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/20 03:52 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - CRPE8660691 [pii] AID - 10.1155/crpe/8660691 [doi] PST - epublish SO - Case Rep Pediatr. 2026 Sep 18;2026:8660691. doi: 10.1155/crpe/8660691. eCollection 2026. PMID- 42763449 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260921 IS - 2732-5121 (Electronic) IS - 2732-5121 (Linking) VI - 5 DP - 2025 TI - Moderate and vigorous physical activity show intensity specific familial and interpersonal association patterns in 9-12-year-olds: A cross-sectional DE-PASS study. PG - 331 LID - 10.12688/openreseurope.21538.4 [doi] LID - 331 AB - BACKGROUND: Research on children's physical activity often examines interpersonal associations but commonly aggregates MPA and VPA into a single MVPA outcome. This approach may obscure intensity-specific association patterns, particularly in intergenerational analyses. METHODS: This cross-sectional study used harmonized data from the European DE-PASS project, including children aged 9-12 years and one of their parents. Waist-worn accelerometry was used to assess MPA and VPA. Perceived parental, peer, and teacher support were measured using validated questionnaires. Intensity-specific associations between parent and child physical activity and between interpersonal support variables and children's activity were examined, including sex-stratified and socioeconomic sensitivity analyses. RESULTS: Parent-child associations differed by activity intensity. Parent-child resemblance was numerically larger for MPA than for VPA, although the difference between intensities was not statistically significant when formally compared; associations involving VPA were weaker and less consistent. Parental co-participation support showed a weak positive association (which did not survive correction for multiple testing) with children's MPA, whereas peer and teacher support showed limited or no associations with children's activity at either intensity. Sex-stratified analyses indicated similar MPA associations across boys and girls, while associations for VPA were not observed among girls. Aggregating MPA and VPA into MVPA may obscure these intensity-specific patterns. CONCLUSIONS: These findings indicate that interpersonal associations with children's physical activity differ by intensity and support examining MPA and VPA as intensity-specific outcomes in intergenerational analyses. Family-based approaches focusing on MPA may represent a pausible direction for future longitudinal and intervention research, while different strategies may be needed to address VPA. CI - Copyright: (c) 2026 Ferreira F et al. FAU - Ferreira, Flavio AU - Ferreira F AUID- ORCID: 0009-0001-0336-5561 AD - Lusofona University of Humanities and Technologies Faculty of Physical Education and Sport, Lisbon, Lisbon, Portugal. FAU - Dowd, Kieran AU - Dowd K AD - Department of Sport and Health Sciences, Technological University of the Shannon Midlands Midwest Faculty of Science and Health, Athlone, County Westmeath, Ireland. FAU - Coffey, Alan AU - Coffey A AD - Department of Sport and Health Sciences, Technological University of the Shannon Midlands Midwest Faculty of Science and Health, Athlone, County Westmeath, Ireland. FAU - Cardon, Greet AU - Cardon G AUID- ORCID: 0000-0003-4983-6557 AD - Department of Movement and Sports Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Flanders, Belgium. FAU - Iliano, Evelien AU - Iliano E AUID- ORCID: 0000-0002-8858-8333 AD - Department of Movement and Sports Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Flanders, Belgium. FAU - Dygryn, Jan AU - Dygryn J AD - Palacky University Olomouc Faculty of Physical Culture, Olomouc, Olomouc Region, Czech Republic. FAU - Pelclova, Jana AU - Pelclova J AD - Palacky University Olomouc Faculty of Physical Culture, Olomouc, Olomouc Region, Czech Republic. FAU - Labisa Palmeira, Antonio AU - Labisa Palmeira A AUID- ORCID: 0000-0001-6508-0599 AD - Lusofona University of Humanities and Technologies Faculty of Physical Education and Sport, Lisbon, Lisbon, Portugal. AD - Lusofona University of Humanities and Technologies Research Center on Sports Physical Education Exercise and Health, Lisbon, Lisbon, Portugal. AD - University of Porto Research Centre for Training Innovation and Intervention in Sport, Porto, Porto District, Portugal. FAU - de Geus, Eco J C AU - de Geus EJC AD - Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20260902 PL - Belgium TA - Open Res Eur JT - Open research Europe JID - 9918230081006676 PMC - PMC13586601 OAB - This study looked at how parents, friends, and teachers might influence how active children aged 9 to 12 are in their daily lives. Physical activity is very important for children's growth and health. Doctors and health organizations recommend at least an hour of activity each day, yet most children around the world are not reaching this level. Being active helps children control their weight, strengthen their bones and muscles, and reduce the risk of health problems later in life. Researchers in Belgium, Czechia, and Ireland asked 181 families to take part. Both children and their parents wore activity trackers for eight days to measure how much moderate activity (like walking or playing outside) and vigorous activity (like running or sports) they did. Children also filled in questionnaires about how much support children felt from parents, friends, and teachers. The results showed that children were more active when their parents were active, especially for moderate activities. For example, if parents often walked or cycled, children were more likely to do the same. Vigorous activity, such as sports, showed weaker links to parents' behaviour and was only slightly connected to friends' encouragement. Teacher support was not found to make a difference in this study. These findings suggest that the best way to help children be more active is through family involvement, especially when parents take part in activities with their children. Friends' influence may become more important as children get older, but for this age group, parents are the strongest role models. This knowledge can help shape programs that aim to get children moving more often and more effectively. OABL- eng OTO - NOTNLM OT - Accelerometry; Physical activity intensity; Interpersonal Support; Parental modelling COIS- No competing interests were disclosed. EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/09/02 CRDT- 2026/09/20 03:45 PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/20 03:45 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 10.12688/openreseurope.21538.4 [doi] PST - epublish SO - Open Res Eur. 2026 Sep 2;5:331. doi: 10.12688/openreseurope.21538.4. eCollection 2025. PMID- 42763398 OWN - NLM STAT- MEDLINE DCOM- 20260919 LR - 20260923 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Sep 11 TI - Evaluating the therapeutic efficacy of a modified ketogenic diet in children with autism spectrum disorder: a randomized controlled trial. LID - 10.1186/s12887-026-07708-3 [doi] LID - 893 AB - BACKGROUND: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder marked by persistent impairments in social communication and interaction, together with restricted and repetitive behavior or interests. Recent epidemiological data indicate that the prevalence of ASD has continued to increase worldwide. Current behavioral and pharmacological interventions remain limited in efficacy, particularly for associated comorbidities. In this context, metabolic interventions, especially the ketogenic diet (KD), have attracted growing interest as a potential therapeutic strategy. METHODS: A total of 62 young children with ASD admitted to Hefei Maternal and Child Health Hospital between January 2024 and January 2025 were prospectively enrolled and randomly assigned to a treatment group or a control group (31 per group). Both groups underwent hospital-based rehabilitation training on weekdays and home-based rehabilitation on weekends over a 2-month period. The treatment group additionally received a modified KD, comprising ketogenic nutritional powder and a structured dietary plan, with lunch provided at the hospital on training days while breakfast, dinner, weekend dietary implementation, and home monitoring were managed by caregivers. The control group followed a regular diet along with the same rehabilitation program. Changes in ASD-related symptoms were assessed using the Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS). RESULTS: After two months of intervention, both groups showed significant reductions in ABC and CARS scores compared with baseline (P < 0.05). Between-group comparison of individual change scores showed larger reductions in the treatment group for both ABC (U = 324.000, P = 0.027) and CARS (U = 273.500, P = 0.003). CONCLUSIONS: In this cohort of young children with ASD, the modified ketogenic diet combined with rehabilitation training was associated with greater short-term reductions in ABC and CARS scores than rehabilitation alone. The intervention demonstrated acceptable short-term feasibility. TRIAL REGISTRATION: The Project was registered on China Clinical Trial Registry (ChiCTR) with the identifier ChiCTR2300075057 ,Registered 24 August 2023, https://www.chictr.org.cn/ . CI - (c) 2026. The Author(s). FAU - Liu, Le AU - Liu L AD - Child Neurological Rehabilitation Center, Hefei Maternal and Child Health Hospital, Hefei, China. FAU - Zhao, Qingsong AU - Zhao Q AD - Anhui Medical University Clinic Medical College, Hefei, China. FAU - Zhou, Jing AU - Zhou J AD - Child Neurological Rehabilitation Center, Hefei Maternal and Child Health Hospital, Hefei, China. FAU - Liu, Zhi AU - Liu Z AD - Shenzhen Zeneca Biotechnology Co., Ltd, Shenzhen, China. FAU - Wu, De AU - Wu D AD - Pediatric Neurorehabilitation Center, Pediatric Department, The First Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - He, Kaiyin AU - He K AUID- ORCID: 0009-0000-2082-9762 AD - Child Neurological Rehabilitation Center, Hefei Maternal and Child Health Hospital, Hefei, China. hekaiyin@126.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260911 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - Male MH - Female MH - *Autism Spectrum Disorder/diet therapy MH - Child, Preschool MH - Treatment Outcome MH - Prospective Studies PMC - PMC13589367 OTO - NOTNLM OT - Autism spectrum disorder OT - Childhood autism rating scale OT - Ketogenic diet OT - Treatment COIS- Declarations. Ethics approval and consent to participate: This study was conducted in strict compliance with the ethical principles outlined in the Declaration of Helsinki. Written informed consent was obtained from all participating children's legal guardians prior to their inclusion in the research. The study protocol received formal approval from the Institutional Review Board of Hefei Maternal and Child Health Hospital (Ethical Approval No.: YYLL2022-07-01-01) following rigorous ethical review procedures. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/09/11 CRDT- 2026/09/19 23:25 PHST- 2026/06/01 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/19 23:25 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.1186/s12887-026-07708-3 [pii] AID - 7708 [pii] AID - 10.1186/s12887-026-07708-3 [doi] PST - epublish SO - BMC Pediatr. 2026 Sep 11;26(1):893. doi: 10.1186/s12887-026-07708-3. PMID- 42763327 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261019 IS - 1476-5624 (Electronic) IS - 1362-4393 (Print) IS - 1362-4393 (Linking) VI - 64 IP - 10 DP - 2026 Oct TI - Blood flow restricted exercise with and without transcutaneous spinal cord stimulation via telehealth in persons with tetraplegia. A protocol for randomized clinical trial. PG - 929-935 LID - 10.1038/s41393-026-01275-1 [doi] AB - STUDY DESIGN: A single site randomized clinical trial; Richmond, VA, USA. OBJECTIVE: To determine the effect of 16 weeks of home-based blood flow restriction-enhanced neuromuscular electrical stimulation (BES) and non-invasive transcutaneous spinal cord stimulation (TSS) with mass practiced (MP) training on cervical neuroplasticity and upper extremity function in individuals with tetraplegia. The program is supported by a telehealth-based approach designed to improve adherence. METHODS: Forty-four adults (18-70 years) with incomplete cervical SCI (AIS B-D; injury level C8 or above) will be randomized to TSS + BES + MP or sham TSS + BES + MP for 30 weeks. All participants, accompanied by a caregiver, will complete a 4-week education and training phase (2 weeks on-site, 2 weeks via telehealth), followed by 16 weeks of telehealth-supervised home training. Baseline assessments will occur before training (BL1) and after the education phase (Phase 1, BL2). Post-intervention (P1) testing will follow 16 weeks of home-based training (Phase 2), with an additional follow-up (Fw) after an 8-week washout period to evaluate any carry-over effects (Phase 3). The first 15 months will serve as a feasibility phase without randomization; data from these participants will be included within the TSS + BES + MP group. Randomization thereafter will be conducted using a computer-generated sequence. Home-based TSS application for upper extremity function is a feasible and safe strategy in persons with tetraplegia. The proposal is likely to ensure long-term compliance and adherence as well as to reduce the barriers associated with exercise interventions in persons with tetraplegia. SPONSORSHIP: National Institute on Disability, Independent Living, and Rehabilitation Research [NIDILRR]. GOV IDENTIFIER: NCT05423600. CI - (c) 2026. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. FAU - Gorgey, Ashraf S AU - Gorgey AS AUID- ORCID: 0000-0002-9157-6034 AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. ashraf.gorgey@va.gov. AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. ashraf.gorgey@va.gov. FAU - Rehman, Muhammad U AU - Rehman MU AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. AD - Virginia Commonwealth University, Department of Biomedical Engineering, Richmond, VA, USA. FAU - Wasim, Momal AU - Wasim M AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. FAU - Khalil, Refka E AU - Khalil RE AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. FAU - Brooks, Bret AU - Brooks B AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. FAU - Seel, Ronald AU - Seel R AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. AD - Virginia Commonwealth University; Center for Rehabilitation Science and Engineering (CERSE), Richmond, VA, USA. FAU - Chaggar, Rajbir AU - Chaggar R AUID- ORCID: 0000-0002-1685-4508 AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. FAU - Lavis, Timothy AU - Lavis T AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. LA - eng SI - ClinicalTrials.gov/NCT05423600 GR - 90SIMS0014/U.S. Department of Health & Human Services | ACL | National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR)/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260919 PL - England TA - Spinal Cord JT - Spinal cord JID - 9609749 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Exercise Therapy/methods MH - *Quadriplegia/rehabilitation/therapy/etiology/physiopathology MH - Regional Blood Flow/physiology MH - *Spinal Cord Injuries/complications/rehabilitation/therapy/physiopathology MH - *Spinal Cord Stimulation/methods MH - Telemedicine MH - *Transcutaneous Electric Nerve Stimulation/methods MH - Randomized Controlled Trials as Topic PMC - PMC13668687 COIS- Competing interests: The author declare no competing interests. EDAT- 2026/09/20 05:43 MHDA- 2026/10/15 07:17 PMCR- 2026/09/19 CRDT- 2026/09/19 23:15 PHST- 2025/11/11 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/08/24 00:00 [revised] PHST- 2026/10/15 07:17 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/19 23:15 [entrez] PHST- 2026/09/19 00:00 [pmc-release] AID - 10.1038/s41393-026-01275-1 [pii] AID - 1275 [pii] AID - 10.1038/s41393-026-01275-1 [doi] PST - ppublish SO - Spinal Cord. 2026 Oct;64(10):929-935. doi: 10.1038/s41393-026-01275-1. Epub 2026 Sep 19. PMID- 42763108 OWN - NLM STAT- MEDLINE DCOM- 20260919 LR - 20260925 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Sep 19 TI - Happiness Toolkit in a paediatric outpatient setting for children with social, emotional, behavioural and/or mental health difficulties: a prospective cohort study. LID - 10.1136/bmjpo-2026-005011 [doi] LID - e005011 AB - OBJECTIVE: To evaluate the feasibility, acceptability and clinical outcomes of the Happiness Toolkit (HTK), a structured, low-intensity, family-delivered intervention for children aged 0-16 years screening positive for social, emotional, behavioural and/or mental health difficulties (SEMHD) in a paediatric outpatient setting. DESIGN: Single-site prospective cohort study; validated age-specific baseline screening, parent-reported outcomes at 6 weeks and 6 months. SETTING: General paediatric outpatient department, secondary hospital, Ireland. PARTICIPANTS: Consecutive paediatric outpatient attendees screening positive for SEMHD on the Ages and Stages Questionnaires: Social-Emotional, Second Edition (under 6 years) or Screen for Child Anxiety Related Emotional Disorders questionnaire (6-16 years) were enrolled for intervention. INTERVENTIONS: The HTK comprises six evidence-based components practised for 5 minutes morning and evening, introduced during routine outpatient consultation. MAIN OUTCOME MEASURES: Primary: consent rate, positive screen rate and 6-week response rate (feasibility); parental willingness to recommend (acceptability). Secondary: parent-reported functional changes at 6 weeks and 6 months, component uptake and adverse events. RESULTS: 240 of 277 families approached across 16 outpatient clinics consented (86.6%); 94 children screened positive for SEMHD (39.2%) and received the HTK. At 6-week follow-up (n=46; 48.9% response rate), 95.2% of parents reported a positive or very positive experience, 73.9% noted improved mood in their child, 43.5% reduced screen time and 37.0% improved sleep patterns. 97.8% would recommend, with no adverse events. At 6-month follow-up (n=13; 13.8% response rate), 61.5% reported sustained child mood improvement and 92.3% would still recommend. CONCLUSIONS: This study demonstrates strong feasibility and high parental acceptability for the HTK when embedded in routine paediatric outpatient care. Parent-reported improvements at 6 weeks and no adverse events at both time points support progression to a controlled evaluation. In Ireland, 4462 children await Child and Adolescent Mental Health Services and over 28 000 await primary care psychology; the HTK represents a promising, pragmatic early and bridging support for emerging SEMHD. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Eustace, Kate AU - Eustace K AUID- ORCID: 0000-0002-1537-9805 AD - Paediatrics, Midland Regional Hospital Mullingar, Mullingar, Ireland kateeustace1@gmail.com. FAU - McCrory, Sarah Alexandra AU - McCrory SA AUID- ORCID: 0009-0004-8525-4567 AD - Paediatrics, Midland Regional Hospital Mullingar, Mullingar, Ireland. FAU - Sharif, Farhana AU - Sharif F AUID- ORCID: 0009-0002-0051-8953 AD - Paediatrics, Midland Regional Hospital Mullingar, Mullingar, Ireland. AD - Paediatrics, RCSI, Dublin, Ireland. LA - eng PT - Journal Article DEP - 20260919 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Prospective Studies MH - Child, Preschool MH - Adolescent MH - Feasibility Studies MH - *Mental Disorders/therapy/diagnosis MH - Infant MH - Surveys and Questionnaires MH - Parents/psychology MH - Ireland MH - *Child Behavior Disorders/therapy/diagnosis MH - *Happiness MH - Infant, Newborn PMC - PMC13599945 OTO - NOTNLM OT - Adolescent Health OT - Child Health OT - Child Psychiatry OT - Psychology OT - Qualitative research EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/19 CRDT- 2026/09/19 20:42 PHST- 2026/05/27 00:00 [received] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 20:42 [entrez] PHST- 2026/09/19 00:00 [pmc-release] AID - 10.1136/bmjpo-2026-005011 [pii] AID - bmjpo-2026-005011 [pii] AID - 10.1136/bmjpo-2026-005011 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Sep 19;10(1):e005011. doi: 10.1136/bmjpo-2026-005011. PMID- 42762635 OWN - NLM STAT- Publisher LR - 20260919 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 228 DP - 2026 Sep 19 TI - Are maternal eating demonstrations associated with infant food acceptance? An observational study of solid food introduction in infancy. PG - 108787 LID - S0195-6663(26)00349-1 [pii] LID - 10.1016/j.appet.2026.108787 [doi] AB - Research with infants highlights an early capacity to learn from social partners, particularly about concepts that would be difficult to learn independently. However, scant literature examines social learning (such as the impact of demonstrations) on infants' acceptance of foods, even though the timeline of solid food introduction (recommended to start at age 6 months) aligns with emerging capacities for infant social learning, making solid foods an ecologically valid category of unfamiliar stimuli. The present research examines whether infants eat more food at 6 (n = 103), 9 (n = 104), and 12 (n = 101) months when their mothers demonstrate eating and the factors that predict maternal eating demonstrations. Although the frequency of maternal eating demonstrations was positively associated with infant bites, we observed low levels of maternal eating demonstrations (fewer than 30% of mothers demonstrated eating at each infant age). Infants tended to eat more of familiar versus unfamiliar foods, yet mothers did not differ in their demonstrations of eating familiar versus unfamiliar foods. Mothers were more likely to demonstrate eating foods when the observations took place during shared meals (rather than individual infant feedings) and when feeding older infants, with more demonstrations occurring at the 9- and 12-month age points compared to the 6-month age point. Eating demonstrations are discussed as a potential target for intervention deserving further study given that we rarely observed spontaneous eating demonstrations in this study. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - DeJesus, Jasmine M AU - DeJesus JM AD - Department of Psychology, College of Arts and Sciences, University of North Carolina at Greensboro, United States. Electronic address: jmdejes2@uncg.edu. FAU - Venkatesh, Shruthi AU - Venkatesh S AD - Department of Psychology, College of Arts and Sciences, University of North Carolina at Greensboro, United States. FAU - Miller, Alison L AU - Miller AL AD - Department of Health Behavior and Health Equity, School of Public Health, University of Michigan, United States. FAU - Gearhardt, Ashley N AU - Gearhardt AN AD - Department of Psychology, College of Literature, Science, & the Arts, University of Michigan, United States. FAU - Sturza, Julie AU - Sturza J AD - Department of Pediatrics, Medical School, University of Michigan, United States. FAU - Lumeng, Julie C AU - Lumeng JC AD - Department of Pediatrics, Medical School, University of Michigan, United States; Department of Nutritional Sciences, School of Public Health, University of Michigan, United States. LA - eng PT - Journal Article DEP - 20260919 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM OTO - NOTNLM OT - Eating behavior OT - Feeding OT - Infant OT - Social learning OT - Social modeling COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Jasmine M. DeJesus reports financial support was provided by American Heart Association Inc. Julie C. Lumeng reports financial support was provided by National Institute of Child Health and Human Development. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:52 CRDT- 2026/09/19 18:03 PHST- 2025/11/03 00:00 [received] PHST- 2026/09/10 00:00 [revised] PHST- 2026/09/13 00:00 [accepted] PHST- 2026/09/19 23:52 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 18:03 [entrez] AID - S0195-6663(26)00349-1 [pii] AID - 10.1016/j.appet.2026.108787 [doi] PST - aheadofprint SO - Appetite. 2026 Sep 19;228:108787. doi: 10.1016/j.appet.2026.108787. PMID- 42762125 OWN - NLM STAT- Publisher LR - 20260919 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Sep 19 TI - Feasibility of millet-based gluten free and casein free diet in children with autism spectrum disorders: A 12-week pilot study in India. PG - 2601060261489302 LID - 10.1177/02601060261489302 [doi] AB - BackgroundAutism spectrum disorder (ASD) is often associated with selective eating, nutritional deficiencies, and gastrointestinal (GI) disturbances. Gluten-free, casein-free (GFCF) diets are popular but inconsistently supported by evidence. Millets, naturally gluten and casein-free, are nutrient-dense traditional grains that may offer a culturally relevant alternative.AimTo assess the feasibility, acceptability, adherence, and nutritional impact of a millet-based GFCF dietary intervention in children with ASD.MethodsA 12-week single-arm pilot study enrolled children aged 4 to 6 years with confirmed ASD. A millet flour blend (foxtail, little, pearl millet) was developed into three recipes: Foxtail Millet Upma, Little Millet Biscuits, and Pearl Millet Nachos. Pre and postintervention dietary intake was measured using 3-day recalls. Sensory acceptability was rated on a nine-point hedonic scale; adherence was tracked through caregiver logs; and structured interviews explored feasibility.SummaryAll millet-based recipes were well accepted, with Foxtail Millet Upma receiving the highest acceptability scores. Significant improvements were observed in cereal and pulse intake, along with a reduction in fat consumption. Caregivers reported improvements in GI comfort (70%), sleep quality (60%), and reductions in hyperactivity (55%). Adherence to the dietary intervention was high (80%), although challenges related to ingredient availability and preparation time were reported. Millet-based GFCF diets are feasible, acceptable, and nutritionally balanced at the food-group level in children with ASD. Findings highlight their potential as culturally appropriate dietary interventions, warranting larger controlled studies to evaluate long-term outcomes. FAU - Dahake, Urmila AU - Dahake U AUID- ORCID: 0000-0001-6822-8317 AD - Department of Pediatrics, All India Institute of Medical Sciences, Nagpur, India. RINGGOLD: 534693 FAU - Deotale, Shweta AU - Deotale S AUID- ORCID: 0000-0003-4409-278X AD - Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, India. RINGGOLD: 29583 FAU - Mandavgane, Sachin AU - Mandavgane S AUID- ORCID: 0000-0002-1436-8987 AD - Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, India. RINGGOLD: 29583 FAU - Sharma, Shakti AU - Sharma S AD - Department of Food Science and Nutrition, Sadabai Raisoni Women's College, Nagpur, India. FAU - Bang, Akash AU - Bang A AUID- ORCID: 0000-0003-2035-1193 AD - Department of Pediatrics, All India Institute of Medical Sciences, Nagpur, India. RINGGOLD: 534693 FAU - Solanki, Ranjan AU - Solanki R AD - Department of Community Medicine, All India Institute of Medical Sciences, Nagpur, India. RINGGOLD: 534693 FAU - Kumar, Anupama AU - Kumar A AUID- ORCID: 0000-0002-9051-1482 AD - Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, India. RINGGOLD: 29583 LA - eng PT - Journal Article DEP - 20260919 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Autism spectrum disorder OT - India OT - casein-free diet OT - food selectivity OT - gluten-free diet OT - gut-brain axis OT - millets OT - nutritional intervention OT - pediatric nutrition EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:52 CRDT- 2026/09/19 07:52 PHST- 2026/09/19 23:52 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 07:52 [entrez] AID - 10.1177/02601060261489302 [doi] PST - aheadofprint SO - Nutr Health. 2026 Sep 19:2601060261489302. doi: 10.1177/02601060261489302. PMID- 42761971 OWN - NLM STAT- MEDLINE DCOM- 20260919 LR - 20261002 IS - 1658-3175 (Electronic) IS - 0379-5284 (Print) IS - 0379-5284 (Linking) VI - 47 IP - 10 DP - 2026 Oct TI - Cranial MRI in Girls With Central Precocious Puberty: Clinical Characteristics and Predictors of Abnormal Findings. PG - 1657-1664 LID - 10.15537/1658-3175.8855 [doi] AB - OBJECTIVES: To describe the clinical profile of girls with central precocious puberty (CPP) and determine the factors associated with abnormal cranial magnetic resonance imaging (MRI) findings. METHODS: This retrospective study included girls aged 8 years or younger with a diagnosis of CPP who received care at King Abdullah Specialized Children's Hospital in Riyadh, Kingdom of Saudi Arabia, between 2015 and 2023. Data on clinical presentation, biochemical results, imaging findings, and treatment were obtained from medical records. Logistic regression analysis was performed to determine variables associated with MRI utilization and the occurrence of abnormal MRI findings. RESULTS: The cohort comprised 70 girls with CPP. The median age at breast development was 7.12 years, and pubertal onset occurred at >/=6 years in 84.3% of patients. Cranial MRI was obtained in 43 patients (61.4%), and abnormal findings were identified in 17 patients (24.3%). Pituitary gland enlargement (n = 6) and hypothalamic hamartoma (n = 4) were the most frequent abnormalities. Girls with a bone age-to-chronological age ratio <1 year had lower odds of undergoing MRI (OR = 0.18, p-value = 0.009). Higher BMI z-scores were independently associated with abnormal MRI findings (OR = 1.95, p-value = 0.043). Other clinical and biochemical variables were not significantly associated with abnormal MRI results. GnRH analogue therapy was initiated in 81.4% of patients. CONCLUSION: Abnormal cranial MRI findings were identified in nearly one-quarter of girls with CPP. Higher BMI z-scores were associated with abnormal MRI findings, whereas age at puberty onset and other clinical variables did not reliably predict intracranial abnormalities. CI - Copyright: (c) Saudi Medical Journal. FAU - Al Juraibah, Fahad N AU - Al Juraibah FN AUID- ORCID: 0000-0003-4471-6281 AD - Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. FAU - Alharbi, Mashael M AU - Alharbi MM AD - Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. FAU - Alharbi, Reem D AU - Alharbi RD AD - Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. FAU - Albaraki, Joud S AU - Albaraki JS AD - Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. FAU - AlDharman, Sarah S AU - AlDharman SS AD - Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. FAU - Alghamdi, Hala A AU - Alghamdi HA AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. FAU - Yenugadhati, Nagarajkumar AU - Yenugadhati N AD - King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. FAU - Alhammad, Abdullah I AU - Alhammad AI AD - Department of Radiology, King Abdullah Specialized Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. FAU - Almutair, Angham N AU - Almutair AN AD - Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. FAU - Al Alwan, Ibrahim A AU - Al Alwan IA AD - Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. AD - King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia. LA - eng PT - Journal Article DEP - 20260910 PL - Saudi Arabia TA - Saudi Med J JT - Saudi medical journal JID - 7909441 RN - Hypothalamic hamartomas SB - IM MH - Humans MH - *Puberty, Precocious/diagnostic imaging/drug therapy MH - Female MH - *Magnetic Resonance Imaging/methods MH - Retrospective Studies MH - Child MH - Hamartoma/diagnostic imaging MH - Hypothalamic Diseases/diagnostic imaging MH - Saudi Arabia MH - Child, Preschool MH - Pituitary Gland/diagnostic imaging/pathology PMC - PMC13588310 OTO - NOTNLM OT - Body mass index OT - Child OT - Hypothalamic hamartoma OT - Magnetic resonance imaging OT - Pituitary gland OT - Precocious puberty EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/10/01 CRDT- 2026/09/19 06:28 PHST- 2026/04/04 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 06:28 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - saudimedj-47-10-1657 [pii] AID - 10.15537/1658-3175.8855 [doi] PST - ppublish SO - Saudi Med J. 2026 Oct;47(10):1657-1664. doi: 10.15537/1658-3175.8855. Epub 2026 Sep 10. PMID- 42761920 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260919 LR - 20260923 IS - 1178-7074 (Print) IS - 1178-7074 (Electronic) IS - 1178-7074 (Linking) VI - 19 DP - 2026 TI - Trajectories of Gestational Weight Gain During Early and Mid-Pregnancy and Their Association with Hypertensive Disorders of Pregnancy. PG - 634468 LID - 10.2147/IJGM.S634468 [doi] LID - 634468 AB - OBJECTIVE: To examine the association between trajectories of gestational weight gain (GWG) during early and mid-pregnancy and hypertensive disorders of pregnancy (HDP). A trajectory approach was used because total GWG or a single measurement cannot represent the timing and pattern of weight change. METHODS: This retrospective cohort included 11,278 women who attended the nutrition clinic and delivered at Fujian Provincial Maternity and Child Health Hospital, Fuzhou, China, between March 2014 and May 2018. Interval-specific GWG through 28 weeks was characterized using latent class growth modeling. Logistic regression estimated associations with HDP; the fully adjusted model included maternal age, pre-pregnancy body mass index, parity, platelet count, lactate dehydrogenase, and alanine aminotransferase. RESULTS: The current analysis used four reported GWG patterns: stable-low (Group 1; n=9,314, 82.6%), early-slow/mid-fast (Group 2; n=70, 0.6%), early-fast/mid-slow (Group 3; n=301, 2.7%), and moderate-growth (Group 4; n=1,593, 14.1%). Compared with Group 1, the fully adjusted odds of HDP were higher in Group 3 (odds ratio [OR]=2.285, 95% confidence interval [CI] 1.370-3.613; P=0.001) and Group 4 (OR=1.356, 95% CI 1.037-1.752; P=0.023), but not Group 2 (OR=1.084, 95% CI 0.176-3.528; P=0.911). CONCLUSION: In this hospital-based cohort, early- and mid-pregnancy GWG patterns were associated with HDP. The estimates for the smallest groups were imprecise, and the observational design does not establish causality or predictive utility. Studies with prospectively recorded HDP diagnosis timing and external validation are required before clinical use. CI - (c) 2026 Li et al. FAU - Li, Wenwen AU - Li W AD - Department of Gynecology II, Fujian Provincial Maternity and Children's Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Kang, Youhong AU - Kang Y AUID- ORCID: 0009-0001-7528-7152 AD - Obstetrics Department, Quanzhou Maternal and Child Health Hospital (Quanzhou Children's Hospital), Quanzhou, Fujian, People's Republic of China. FAU - Zhang, Huale AU - Zhang H AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Tan, Wenxin AU - Tan W AD - Department of Obstetrics, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Li, Feng AU - Li F AD - Department of Gynecology II, Fujian Provincial Maternity and Children's Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Wu, Kunhai AU - Wu K AD - Blood Transfusion Department, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. AD - Blood Transfusion Department, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Fang, Zhuanji AU - Fang Z AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. LA - eng PT - Journal Article DEP - 20260914 PL - New Zealand TA - Int J Gen Med JT - International journal of general medicine JID - 101515487 PMC - PMC13588108 OTO - NOTNLM OT - gestational weight gain OT - hypertensive disorders of pregnancy OT - latent class growth model OT - longitudinal trajectory OT - pregnancy COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/14 CRDT- 2026/09/19 06:25 PHST- 2026/07/08 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 06:25 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - 634468 [pii] AID - 10.2147/IJGM.S634468 [doi] PST - epublish SO - Int J Gen Med. 2026 Sep 14;19:634468. doi: 10.2147/IJGM.S634468. eCollection 2026. PMID- 42761388 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260919 LR - 20260921 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 9 DP - 2026 Sep TI - Lifestyle Behaviors and Their Socio-Demographic Correlates Among University-Going Adolescents in Rawalpindi, Pakistan: A Cross-Sectional Study. PG - e73240 LID - 10.1002/hsr2.73240 [doi] LID - e73240 AB - OBJECTIVE: Adolescence is a critical period where lifestyle habits, including diet, physical exercise, sleep, and substance abuse, may have a significant influence on future health. The objective of this study was to determine adolescents' lifestyle behaviors and how they relate to socio-demographic characteristics. METHODS: The study included university-going older adolescents in Rawalpindi, Pakistan and employed a cross-sectional study design. Participants completed a validated questionnaire assessing lifestyle behaviors and their socio-demographic correlates, along with anthropometric measurements for BMI categorization. Chi-square test and multivariate logistic regression were used for analysis. RESULTS: The present study included 215 university-going older adolescents (mean age: 18.69 SD = 0.46 years); the majority (75.8%) were female participants, and 70.2% were urban inhabitants. The majority had a healthy BMI (68.8%) and ate three meals each day (90.7%), but less than 12% were physically active. Over a quarter reported not getting enough sleep. 28.4% of participants reported depressed symptoms; just 10.2% addressed their problems with a specialist. 9.8% used drugs (smoking), 20.9% vaped, and 25.6% began using before the age of 12. There were significant (p < 0.05) associations between lifestyle behaviors and socio-demographic characteristics such as age, BMI, and family type. Regression analysis showed BMI, residence, and parental education as key predictors of adolescent lifestyle. CONCLUSION: The findings revealed significant gaps in healthy lifestyle behaviors university-going older adolescents in Rawalpindi. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Rao, Meesha AU - Rao M AD - Department of Research and Development Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi Pakistan. FAU - Mahmood, Humaira AU - Mahmood H AUID- ORCID: 0000-0003-2341-6431 AD - School of Public Health Health Services Academy Islamabad Pakistan. FAU - Ahmad, Abdul Momin Rizwan AU - Ahmad AMR AUID- ORCID: 0000-0003-3499-902X AD - Department of Human Nutrition and Dietetics, NUST School of Health Sciences National University of Sciences and Technology (NUST) Islamabad Pakistan. AD - Department of Health Sciences University of York York UK. FAU - Zafar, Saira AU - Zafar S AUID- ORCID: 0009-0007-1850-5081 AD - School of Public Health Health Services Academy Islamabad Pakistan. FAU - Khalid, Hasnain AU - Khalid H AD - School of Management Xuzhou Medical University Xuzhou China. FAU - Siddiqui, Manaar Adil AU - Siddiqui MA AD - Department of Public Health, Armed Forces Postgraduate Medical Institute (AFPGMI) National University of Medical Sciences (NUMS) Rawalpindi Pakistan. FAU - Azad, Naseem AU - Azad N AD - Department of Public Health, Armed Forces Postgraduate Medical Institute (AFPGMI) National University of Medical Sciences (NUMS) Rawalpindi Pakistan. FAU - Abbasi, Attiya Najeeb AU - Abbasi AN AD - Department of Public Health, Armed Forces Postgraduate Medical Institute (AFPGMI) National University of Medical Sciences (NUMS) Rawalpindi Pakistan. FAU - Mohammadi, Nilab AU - Mohammadi N AUID- ORCID: 0009-0003-6376-0007 AD - Department of Curative Medicine Ghalib University Herat Afghanistan. LA - eng PT - Journal Article DEP - 20260917 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13586443 OTO - NOTNLM OT - adolescents OT - lifestyle behaviors OT - physical activity OT - socio-demographic correlates OT - university students COIS- The authors declare that they do not have any conflict of interest. EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/17 CRDT- 2026/09/19 05:36 PHST- 2026/07/25 00:00 [received] PHST- 2026/08/27 00:00 [revised] PHST- 2026/09/05 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 05:36 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - HSR273240 [pii] AID - 10.1002/hsr2.73240 [doi] PST - epublish SO - Health Sci Rep. 2026 Sep 17;9(9):e73240. doi: 10.1002/hsr2.73240. eCollection 2026 Sep. PMID- 42761262 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260919 LR - 20260921 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - A comprehensive narrative review of scoliosis in children and adolescents: epidemiology, screening strategies, therapeutic interventions, and biomechanical research. PG - 1866246 LID - 10.3389/fped.2026.1866246 [doi] LID - 1866246 AB - Scoliosis in children and adolescents, particularly adolescent idiopathic scoliosis (AIS), is a complex three-dimensional spinal deformity with a well-defined global prevalence and a considerable disease burden. This narrative review synthesizes the latest advances in the field, encompassing epidemiology, screening strategies, conservative treatment (bracing and physiotherapeutic scoliosis-specific exercises), biomechanical research, and artificial intelligence applications. A recent global meta-analysis indicates that the overall prevalence of scoliosis in children and adolescents is approximately 1.65%, with a consistent female predominance observed across most studies (global pooled OR = 2.16, 95% CI: 2.01-2.33), although the magnitude of this sex disparity varies by region, and prevalence increasing with age. However, the included studies are geographically unbalanced, with limited data from low-latitude regions, which may bias the global prevalence estimate. School-based screening remains the cornerstone of early detection, but screening policies vary significantly across countries. The development of novel home-based screening tools offers a new approach to overcome the limitations of school screening, yet their widespread adoption is constrained by economic factors and parental awareness. Multiple randomized controlled trials and meta-analyses have confirmed the efficacy of bracing and physiotherapeutic scoliosis-specific exercises, but no unified clinical guidelines exist for selecting the optimal treatment strategy. Furthermore, long-term longitudinal evidence on the intrinsic link between treatment approaches and patients' mental health is still lacking. In addition, biomechanical techniques such as finite element analysis provide new perspectives for elucidating the mechanical properties of scoliosis and optimizing treatment strategies, but most models are constructed under idealized conditions, differing from the physiological state, and their clinical translational value awaits further validation. This review integrates core evidence from the field, aiming to provide a reference for clinical practice and future research directions. CI - (c) 2026 Chuan, Feina, Aigong and Shaoling. FAU - Chuan, Sun AU - Chuan S AD - Binzhou Medical University, Binzhou, Shandong, China. AD - Zhaoyuan Hospital of Traditional Chinese Medicine, Yantai, Shandong, China. FAU - Feina, Cong AU - Feina C AD - Zhaoyuan Hospital of Traditional Chinese Medicine, Yantai, Shandong, China. FAU - Aigong, Qiu AU - Aigong Q AD - Zhaoyuan Hospital of Traditional Chinese Medicine, Yantai, Shandong, China. FAU - Shaoling, Xu AU - Shaoling X AD - Zhaoyuan Hospital of Traditional Chinese Medicine, Yantai, Shandong, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260904 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13585927 OTO - NOTNLM OT - adolescent idiopathic scoliosis OT - artificial intelligence OT - biomechanics OT - bracing OT - epidemiology OT - exercise therapy OT - mental health OT - screening strategies COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/04 CRDT- 2026/09/19 05:22 PHST- 2026/04/27 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 05:22 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - 10.3389/fped.2026.1866246 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 4;14:1866246. doi: 10.3389/fped.2026.1866246. eCollection 2026. PMID- 42760922 OWN - NLM STAT- MEDLINE DCOM- 20260919 LR - 20260920 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Pre-Ramadan time-below-range stratifies the simulated pump basal-rate dose-response during Ramadan fasting: a five-policy paired virtual-patient study. PG - 1922149 LID - 10.3389/fendo.2026.1922149 [doi] LID - 1922149 AB - BACKGROUND: Pump basal-rate reduction during Ramadan may prevent hypoglycemia but can increase hyperglycemia. Its dose-response relation and phenotype-dependent trade-off remain uncertain. METHODS: Thirty UVA/Padova virtual patients (10 children, 10 adolescents, 10 adults) underwent paired 30-day Ramadan conditions delivering 100%, 90%, 80%, 70%, or 60% of the pump steady-state basal rate. The primary complete-case analysis included 29 virtual patients. Outcomes were time in range (TIR), time below range (TBR), time above range (TAR, including TAR > 250 and TAR > 300), and rescue corrections. Paired permutation tests and bootstrap intervals quantified effects. Robustness and revision analyses used three sensor seeds, three seeded meal/timing scenarios with a held-out evaluation, a reactive-correction sensitivity analysis, a time-of-day decomposition, terminal-event reporting, and a negative-control (sham) test of the pre-Ramadan marker. RESULTS: Mean TIR was 81.7%, 79.9%, 73.9%, 65.3%, and 56.0% at 100%, 90%, 80%, 70%, and 60%, respectively (P <0.001). Compared with 100%, 90% basal reduced TBR by 1.6 percentage points (95% CI -2.1 to -1.2) while changing TIR by -1.8 points (95% CI -3.7 to -0.3; Holm-adjusted P = 0.031). Severe hyperglycemia rose steeply with deeper reduction (TAR>250: 2.9% at 100% to 14.8% at 60%). Enabling realistic reactive corrections raised TIR at the deepest policies but preserved the same policy ordering. Pre-Ramadan TBR stratified the TIR response across reduced policies (omnibus patient-blocked permutation P = 0.023), with the strongest gradients at 70% and 60% basal; a negative-control analysis showed this signal was not specific to TBR but reflected a broader baseline-glycemia pattern. In a held-out scenario, a revised safety-first selection rule improved hypoglycemia-target attainment (39% to 79%) and reduced TBR by 2.9 points but incurred a 5.2-point TIR cost, demonstrating that prioritizing fasting safety involves a glycemic trade-off. CONCLUSION: Ramadan pump basal-rate reduction should be treated not as a uniform percentage change but as a phenotype- and context-dependent trade-off. Among the reduced policies, 90% basal produced the smallest TIR loss while lowering hypoglycemia; pre-Ramadan TBR was an exploratory candidate stratifier; and meal-size associations differed by policy. These mechanistic findings apply to simulated pump basal-rate modulation and require prospective, CGM-anchored validation before any clinical use. CI - Copyright (c) 2026 Banjar. FAU - Banjar, Ameen AU - Banjar A AD - Department of Information Systems and Technology, College of Computer Science and Engineering, University of Jeddah, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260904 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Blood Glucose) RN - 0 (Insulin) RN - 0 (Hypoglycemic Agents) SB - IM MH - Humans MH - Adolescent MH - Male MH - *Islam MH - Female MH - Blood Glucose/analysis/metabolism MH - *Fasting MH - Child MH - *Insulin Infusion Systems MH - Adult MH - *Insulin/administration & dosage MH - *Hypoglycemia/prevention & control MH - Intermittent Fasting MH - *Diabetes Mellitus, Type 1/drug therapy/blood MH - Hypoglycemic Agents/administration & dosage MH - Hyperglycemia/prevention & control MH - Young Adult PMC - PMC13585517 OTO - NOTNLM OT - basal insulin OT - continuous glucose monitoring OT - dose response OT - precision dosing OT - ramadan OT - treatment heterogeneity OT - type 1 diabetes OT - virtual patients COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/19 05:39 MHDA- 2026/09/19 05:40 PMCR- 2026/09/04 CRDT- 2026/09/19 04:28 PHST- 2026/06/28 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/09/19 05:40 [medline] PHST- 2026/09/19 05:39 [pubmed] PHST- 2026/09/19 04:28 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - 10.3389/fendo.2026.1922149 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 4;17:1922149. doi: 10.3389/fendo.2026.1922149. eCollection 2026. PMID- 42760401 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 10 DP - 2026 Sep 19 TI - Risk factors for acute kidney injury after pediatric liver transplantation: a systematic review and meta-analysis. LID - 764 [pii] LID - 10.1007/s00431-026-07419-y [doi] AB - This study sought to systematically evaluate the incidence rates and risk factors of acute kidney injury (AKI) following pediatric liver transplantation (PLT), providing robust evidence for early identification of high-risk pediatric patients and development of perioperative intervention strategies. PubMed, Cochrane Library, Web of Science, and Embase were searched from their inception to September 2025 for observational studies on risk factors for AKI following PLT. Literature screening, data extraction, and quality assessment were independently completed by two researchers. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of included studies. Meta-analysis was conducted using StataMP 17.0. In total, 17 retrospective cohort studies were included, involving 2986 pediatric liver transplant recipients. The pooled incidence rate of AKI following PLT was 30.7% [95% CI (25.0%, 36.3%)]. Several perioperative and patient-related factors may be associated with postoperative AKI. However, many of these factors were evaluated in only a small number of studies, and the corresponding pooled estimates should therefore be interpreted cautiously. Sensitivity analyses showed that the overall pooled estimates were robust, and the impact of publication bias was minimal. Conclusion: The incidence rate of AKI following PLT is relatively high. Furthermore, its occurrence is influenced by multiple factors, including preoperative hepatic impairment, coagulation abnormalities, inadequate nutrition and oxygen delivery, intraoperative blood loss, transfusion burden, and ischemia-reperfusion injury, and the requirement for continuous postoperative organ support. Clinically, comprehensive risk assessment and management across the entire perioperative period should be strengthened. Moreover, early identification of high-risk patients and implementation of targeted interventions should be prioritized to reduce the risk of AKI and improve clinical outcomes. However, the evidence for many individual factors was derived from a limited number of studies and should be interpreted cautiously. Further large-scale prospective studies are needed to validate these associations and guide risk-stratified perioperative management. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Cai, Wenjun AU - Cai W AD - School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. FAU - Wang, Danting AU - Wang D AD - School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. FAU - Zhu, Lu AU - Zhu L AD - The Second Affiliated Hospital, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. FAU - Liu, Xiujuan AU - Liu X AD - School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. liuxinfanjian@126.com. AD - Department of Nephrology, The 908th, Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, 330002, Jiangxi, China. liuxinfanjian@126.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260919 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Acute Kidney Injury/epidemiology/etiology MH - *Liver Transplantation/adverse effects MH - Risk Factors MH - Child MH - *Postoperative Complications/epidemiology/etiology MH - Incidence OTO - NOTNLM OT - Acute kidney injury OT - Children OT - Liver transplantation OT - Meta-analysis OT - Risk factors COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable. Declaration of artificial intelligence: The authors declare that no artificial intelligence was used at the time of writing the paper. EDAT- 2026/09/19 05:39 MHDA- 2026/09/19 05:40 CRDT- 2026/09/18 23:33 PHST- 2026/07/15 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/19 05:40 [medline] PHST- 2026/09/19 05:39 [pubmed] PHST- 2026/09/18 23:33 [entrez] AID - 10.1007/s00431-026-07419-y [pii] AID - 10.1007/s00431-026-07419-y [doi] PST - epublish SO - Eur J Pediatr. 2026 Sep 19;185(10):764. doi: 10.1007/s00431-026-07419-y. PMID- 42759561 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261013 IS - 1361-6579 (Electronic) IS - 0967-3334 (Linking) VI - 47 IP - 10 DP - 2026 Oct 13 TI - Improving sleep monitoring in athletes: a comparative evaluation of four automated sleep scoring algorithms on 204 polysomnography recordings. LID - 10.1088/1361-6579/aea9ea [doi] AB - Objective.Automated sleep scoring offers the potential for fast, precise, and cost-effective analysis. This study evaluated the accuracy, robustness, and clinical agreement of four algorithms against manual polysomnography (PSG) in athletes, and assessed how signal degradation and individual physiological traits affect automated scoring in ambulatory settings.Approach.Data from 75 healthy athletes (91.1% male, mean age 26.3 +/- 5.4 years, range [18-41], 204 PSG recordings) were retrospectively collected from studies conducted in our laboratory. Manual scoring was compared to four automated sleep staging algorithms: Luna, U-Sleep, Yet Another Spindle Algorithm (YASA), and Greifswald Sleep Stage Classifier (GSSC). Performance was evaluated on accuracy (per stage, macro and weightedF1), sensitivity (confusion matrices), robustness (signal quality:R(2); individual differences: beta coefficients) and clinical relevance (prediction of total sleep time (TST), sleep onset latency (SOL), wake after sleep onset (WASO) and sleep efficiency (SE)).Main results.All algorithms demonstrated strong agreement with manual scoring, with macroF1 scores of 0.76 (GSSC), 0.71 (U-Sleep), 0.70 (YASA), and 0.69 (Luna). GSSC was the most accurate and robust across sport, physiological, behavioral, and anthropometric variables. It showed minimal bias and narrow limits of agreement for TST, WASO and SE. GSSC was also the most resilient to signal degradation (marginalR(2)= 0.05), compared to YASA and Luna (0.06) and U-Sleep (0.24).Significance.Automated sleep staging algorithms demonstrated accuracy comparable to typical inter-rater agreement, supporting broader use in athletes. These algorithms could make PSG more accessible for both monitoring and research, providing deeper insights into sleep and its influence on athletic performance. CI - Creative Commons Attribution license. FAU - Crosbie, Flynn AU - Crosbie F AUID- ORCID: 0009-0006-1635-194X AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - INSEP (Institut National du Sport, de l'Expertise et de la Performance), Paris, France. FAU - Hanif, Umaer AU - Hanif U AUID- ORCID: 0000-0001-8288-5532 AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. FAU - Aloulou, Anis AU - Aloulou A AUID- ORCID: 0000-0002-4124-3864 AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - APHP, Hotel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France. FAU - Chauvineau, Maxime AU - Chauvineau M AUID- ORCID: 0000-0002-0690-8074 AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - APHP, Hotel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France. FAU - Chennaoui, Mounir AU - Chennaoui M AUID- ORCID: 0000-0002-4409-813X AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - IRBA (Institut de Recherche biomedicale des armees), Bretigny, France. FAU - Nedelec, Mathieu AU - Nedelec M AUID- ORCID: 0000-0001-8095-9163 AD - INSEP (Institut National du Sport, de l'Expertise et de la Performance), Paris, France. FAU - Leger, Damien AU - Leger D AUID- ORCID: 0000-0003-1168-480X AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - APHP, Hotel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France. LA - eng PT - Comparative Study PT - Evaluation Study PT - Journal Article DEP - 20261013 PL - England TA - Physiol Meas JT - Physiological measurement JID - 9306921 SB - IM MH - Humans MH - *Polysomnography/methods MH - *Algorithms MH - Male MH - Adult MH - Female MH - Automation MH - Adolescent MH - *Athletes MH - *Sleep/physiology MH - Young Adult MH - Sleep Stages MH - Sleep Duration MH - Signal Processing, Computer-Assisted OTO - NOTNLM OT - EEG OT - artificial intelligence OT - athletes OT - automated scoring OT - polysomnography OT - sleep staging EDAT- 2026/09/18 23:36 MHDA- 2026/10/13 17:37 CRDT- 2026/09/18 19:08 PHST- 2026/05/09 00:00 [received] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/13 17:37 [medline] PHST- 2026/09/18 23:36 [pubmed] PHST- 2026/09/18 19:08 [entrez] AID - 10.1088/1361-6579/aea9ea [doi] PST - epublish SO - Physiol Meas. 2026 Oct 13;47(10). doi: 10.1088/1361-6579/aea9ea. PMID- 42758477 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260922 IS - 1460-2210 (Electronic) IS - 0141-5387 (Print) IS - 0141-5387 (Linking) VI - 48 IP - 5 DP - 2026 Aug 6 TI - Metabolomic analysis of gingival crevicular fluid for dental age and skeletal maturity assessment in growing individuals. LID - 10.1093/ejo/cjag064 [doi] LID - cjag064 AB - OBJECTIVES: The aim of this study was to examine the metabolic profile of growing patients for potential identification of biomarkers related to dental skeletal development. MATERIALS AND METHODS: Gingival crevicular fluid samples from 54 young patients were collected and further analyzed by an untargeted gas chromatography-mass spectrometry method. For the estimation of dental development, the Demirjian method was used, and for the skeletal maturation level, the cervical vertebrae maturation method was applied. Multivariate and univariate analyses were performed to examine possible metabolomic variations according to the chronological, dental, and skeletal age. Group differences were evaluated using Kruskal-Wallis tests, with Bonferroni correction applied to account for multiple comparisons. Spearman's rho correlation coefficient was used to examine variable correlations. Metabolite expression variations were visualized using boxplots. RESULTS: In total, 63 compounds were retrieved with metabolomic analysis. The results showed that cadaverine and L-valine uniquely displayed robust dental age-related variation, demonstrating significant elevations during tooth development and decrease in the late stages of the dentition. Malonic acid and nonanoic acid decrease with advanced dental age. Regarding bone growth, cadaverine, L-serine, and L-homoserine have been identified as strong indicators of skeletal maturation. CONCLUSIONS: Several distinct metabolites showed coherent associations with skeletal and dental maturation. Additional studies employing complementary analytical methods and broader metabolome profiling are necessary to validate their association with tooth and bone growth pathways. CLINICAL SIGNIFICANCE: The adjunct use of metabolomics in dentistry and orthodontics may lead to more precise diagnosis and personalized healthcare. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Orthodontic Society. FAU - Eirini, Tsagkari AU - Eirini T AD - Department of Orthodontics, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Eleftherios, Panteris AU - Eleftherios P AD - Biomic_AUTh, CIRI-AUTH Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Moschos, Papadopoulos A AU - Moschos PA AD - Department of Orthodontics, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Athina, Chatzigianni AU - Athina C AUID- ORCID: 0000-0001-7114-689X AD - Department of Orthodontics, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. LA - eng GR - Greece/ GR - MIS 5047928/European Union (European Social Fund-ESF)/ PT - Journal Article PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Gingival Crevicular Fluid/chemistry/metabolism MH - *Age Determination by Teeth/methods MH - *Metabolomics/methods MH - Gas Chromatography-Mass Spectrometry/methods MH - Female MH - Child MH - Biomarkers/analysis/metabolism MH - Male MH - *Age Determination by Skeleton/methods MH - Cervical Vertebrae/growth & development MH - Adolescent MH - *Odontogenesis/physiology MH - *Bone Development/physiology PMC - PMC13587827 OTO - NOTNLM OT - biomarkers OT - dentistry OT - metabolomics OT - orthodontics OT - skeletal growth OT - tooth development COIS- Conflicts of interest: The authors declare that there is no conflict of interest. EDAT- 2026/09/18 17:36 MHDA- 2026/09/18 17:37 PMCR- 2026/09/18 CRDT- 2026/09/18 11:26 PHST- 2026/09/18 17:37 [medline] PHST- 2026/09/18 17:36 [pubmed] PHST- 2026/09/18 11:26 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 8817247 [pii] AID - cjag064 [pii] AID - 10.1093/ejo/cjag064 [doi] PST - ppublish SO - Eur J Orthod. 2026 Aug 6;48(5):cjag064. doi: 10.1093/ejo/cjag064. PMID- 42757670 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20261001 IS - 1536-7290 (Electronic) IS - 1746-1391 (Print) IS - 1536-7290 (Linking) VI - 26 IP - 10 DP - 2026 Oct TI - Measurement Agreement and Reliability of the 6-m Gait Speed Test in Adult Population: The ADULT-FIT Project. PG - e70207 LID - 10.1002/ejsc.70207 [doi] LID - e70207 AB - We aimed to examine: (i) measurement agreement between photoelectric cell system and manual stopwatch timing; (ii) inter-rater agreement between trained and untrained raters using manual stopwatch timing; and (iii) reliability of the 6-m gait speed test to assess motor fitness in adults, according to sex, age, and physical activity levels. 410 healthy adults (203 females) aged 18-64 years participated in this study. The time required to perform the 6-m gait speed test was recorded simultaneously by a trained (R1) and an untrained (R2) rater (inter-rater reliability), and by photoelectric cells (measurement agreement between timing methods). The test was repeated under the identical conditions (test-retest reliability) 48-72 h later. Systematic error between photoelectric cells and R1 was close to zero (0.015 s), whereas a larger difference was observed for R2 ( approximately 0.2 s). The corresponding concordance correlation coefficients (CCC) were 0.966 and 0.861, respectively. There was a systematic error between R2 and R1 of approximately 0.2 s, with a CCC of 0.872. Test-retest systematic error was -0.047 s (p < 0.01), with an effect size of 0.067. The intraclass correlation coefficient was 0.984, and all error measurements reported low values, except the coefficient of variation that was 14.386. No heteroscedasticity was observed (p > 0.05). Measurement agreements and reliability were not influenced by sex, age groups and physical activity levels. Manual timing by R1 demonstrated high agreement with photoelectric cells and high test-retest reliability for assessing 6-m gait speed test in adults. Rater training is strongly recommended to minimize measurement error. CI - (c) 2026 The Author(s). European Journal of Sport Science published by Wiley-VCH GmbH on behalf of European College of Sport Science. FAU - Castro-Pinero, Jose AU - Castro-Pinero J AUID- ORCID: 0000-0002-7353-0382 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Marin-Jimenez, Nuria AU - Marin-Jimenez N AUID- ORCID: 0000-0002-0687-7554 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. AD - Department of Education, Faculty of Educational Sciences, Health Research Centre, University of Almeria, Almeria, Spain. FAU - Cruz-Leon, Carolina AU - Cruz-Leon C AUID- ORCID: 0000-0001-9070-5693 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Cies Valleras, Francisco Javier AU - Cies Valleras FJ AUID- ORCID: 0009-0001-1857-1245 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Borges-Cosic, Milkana AU - Borges-Cosic M AUID- ORCID: 0000-0002-8276-9387 AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Physical Activity for Health Promotion Research Group (PAHELP), University of Granada, Granada, Spain. AD - Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cadiz, Spain. FAU - Camiletti-Moiron, Daniel AU - Camiletti-Moiron D AUID- ORCID: 0000-0002-8856-5967 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Cuenca-Garcia, Magdalena AU - Cuenca-Garcia M AUID- ORCID: 0000-0002-8510-9253 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. LA - eng GR - DEP2017-88043-R/This project was supported by the Ministry of Economy, Industry and Competitiveness in the 2017 call for R&D Projects of the State Program for Research, Development and Innovation Targeting the Challenges of the Company; National Plan for Scientific and Technical Research and Innovation 2013-2016; the Spanish Ministry of Education, Culture and Sport; Spanish Ministry of Universities, funded by the European Union-NextGenerationEU; "Salvador de Madariaga" Senior Mobility Grant Program from the Ministry of Universities; and the Juan de la Cierva Fellowship from the Spanish Ministry of Science and Innovation./ PT - Journal Article PL - Germany TA - Eur J Sport Sci JT - European journal of sport science JID - 101146739 SB - IM MH - Humans MH - Reproducibility of Results MH - Female MH - Adult MH - Male MH - Young Adult MH - *Walking Speed MH - Middle Aged MH - Adolescent MH - Observer Variation MH - *Exercise Test/methods MH - *Physical Fitness PMC - PMC13587142 OTO - NOTNLM OT - adults OT - field-based test OT - measurement concordance OT - motor fitness OT - physical fitness OT - reproducibility COIS- The authors declare no conflicts of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/18 CRDT- 2026/09/18 09:08 PHST- 2026/05/23 00:00 [revised] PHST- 2025/11/06 00:00 [received] PHST- 2026/06/07 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 09:08 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - EJSC70207 [pii] AID - 10.1002/ejsc.70207 [doi] PST - ppublish SO - Eur J Sport Sci. 2026 Oct;26(10):e70207. doi: 10.1002/ejsc.70207. PMID- 42757245 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260919 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Activity-function transitions and interpretable machine learning for predicting incident depressive symptoms among ACE-exposed middle-aged and older adults: a multi-cohort study. PG - 1924836 LID - 10.3389/fpubh.2026.1924836 [doi] LID - 1924836 AB - BACKGROUND: Ad--verse childhood experiences (ACEs) are associated with increased risk of depressive symptoms in later life. This study aimed to develop and externally validate an interpretable machine-learning model for predicting incident depressive symptoms among ACE-exposed middle-aged and older adults. METHODS: Data were obtained from the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS). Participants with baseline depressive symptoms were excluded. ELSA was used for model development and HRS for external validation. LASSO regression was applied for predictor selection, followed by comparison of multiple machine-learning algorithms. Pre-outcome activity-function transition profiles were further examined in relation to observed incident depressive symptoms. RESULTS: LASSO identified stable predictors mainly involving physical function, physical activity, chronic conditions, and sociodemographic characteristics. Among the evaluated models, random forest demonstrated the best performance, with an AUC of 0.701 in ELSA and 0.693 in HRS external validation. SHAP analysis identified walking time, grip strength, falls, arthritis, and physical activity as important contributors to prediction. Participants with unfavorable activity-function status at both pre-outcome assessments showed higher odds of incident depressive symptoms in both cohorts. CONCLUSION: An interpretable machine-learning framework integrating physical performance, physical activity, and health-related factors achieved moderate and externally validated prediction of incident depressive symptoms among ACE-exposed adults. Pre-outcome activity-function transition profiles provided additional information on subsequent depressive-symptom risk. Given the moderate discrimination and limited case-detection ability, the framework should be regarded as exploratory and requires further validation and refinement before any clinical application. CI - Copyright (c) 2026 Lin, Shangguan, Sim, Chen and Wang. FAU - Lin, Zhenhao AU - Lin Z AD - Department of Pediatrics, Binhai County People's Hospital, Yancheng, Jiangsu, China. AD - Department of Exercise Physiology, Kunsan National University, Gunsan, Republic of Korea. FAU - Shangguan, Yuwen AU - Shangguan Y AD - Department of Exercise Physiology, Kunsan National University, Gunsan, Republic of Korea. AD - School of Rehabilitation Medicine, Jining Medical University, Jining, Shandong, China. FAU - Sim, Young-Je AU - Sim YJ AD - Department of Exercise Physiology, Kunsan National University, Gunsan, Republic of Korea. FAU - Chen, Dahua AU - Chen D AD - Department of Exercise Physiology, Kunsan National University, Gunsan, Republic of Korea. FAU - Wang, Xiang AU - Wang X AD - Department of Pediatrics, Binhai County People's Hospital, Yancheng, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Depression/epidemiology MH - *Machine Learning MH - Male MH - Middle Aged MH - Aged MH - Longitudinal Studies MH - *Adverse Childhood Experiences/statistics & numerical data/psychology MH - Predictive Learning Models MH - *Exercise/psychology MH - Incidence MH - Risk Factors MH - Prediction Algorithms PMC - PMC13584956 OTO - NOTNLM OT - adverse childhood experiences OT - depression OT - longitudinal cohort OT - machine learning OT - middle-aged and older adults OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:26 MHDA- 2026/09/18 12:27 PMCR- 2026/09/03 CRDT- 2026/09/18 08:37 PHST- 2026/07/01 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/18 12:27 [medline] PHST- 2026/09/18 12:26 [pubmed] PHST- 2026/09/18 08:37 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1924836 [doi] PST - epublish SO - Front Public Health. 2026 Sep 3;14:1924836. doi: 10.3389/fpubh.2026.1924836. eCollection 2026. PMID- 42756624 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 1728-869X (Print) IS - 2226-5104 (Electronic) IS - 1728-869X (Linking) VI - 24 IP - 4 DP - 2026 Oct TI - Evaluation of the Government indicator methodology in the Global Matrix on physical activity for children and adolescents. PG - 200520 LID - 10.1016/j.jesf.2026.200520 [doi] LID - 200520 AB - BACKGROUND/OBJECTIVES: The Government indicator evaluates national policies and strategies for child and adolescent physical activity, supporting country reporting and international comparisons within the Global Matrix initiative. To grade this indicator, countries/jurisdictions apply either the original method or, in recent editions, an alternative approach. The alternative approach was proposed by the Welsh team, who derived six criteria from the World Health Organization's Health-Enhancing Physical Activity Policy Audit Tool v2 and developed an accompanying scoring rubric. This study aimed to evaluate the Welsh approach in comparison with the original method to guide recommendations for future applications. METHODS: The study employed a mixed-methods design, including: 1) inductive content analysis of feedback collected via survey from 17 researchers and policy professionals from various countries, and 2) descriptive and Wilcoxon signed-rank analysis of Government indicator grades from Global Matrices 3.0 and 4.0 in 6 countries that transitioned to the Welsh approach and 28 countries/jurisdictions that retained the original method. RESULTS: User feedback on the Welsh approach was predominantly positive, noting its structure, transparency, and comprehensiveness as strengths, and indicating greater utility and suitability than the original method. Concerns included limited consideration of policy implementation and feasibility aspects. No statistically significant group-level temporal grade differences were found for both methods. CONCLUSION: The Welsh approach adds structure and transparency to the Government indicator assessment. Further refinements to the Welsh approach may improve comparability and policy relevance, while both the Welsh and original methods remain acceptable for interim use within the Global Matrix, with potential applicability beyond it. CI - (c) 2026 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier B.V. FAU - Demchenko, Iryna AU - Demchenko I AD - Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Department of Health Sciences, Carleton University, Ottawa, ON, Canada. AD - Active Healthy Kids Global Alliance, Ottawa, ON, Canada. FAU - Aubert, Salome AU - Aubert S AD - Active Healthy Kids Global Alliance, Ottawa, ON, Canada. FAU - Kuzik, Nicholas AU - Kuzik N AD - Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. FAU - Edwards, Lowri C AU - Edwards LC AD - Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Wales, UK. FAU - Ward, Malcolm AU - Ward M AD - Applied Sports Technology, Exercise and Medicine Research Centre (A-STEM), Swansea University, Wales, UK. FAU - Arbour-Nicitopoulos, Kelly P AU - Arbour-Nicitopoulos KP AD - Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada. FAU - Brazo-Sayavera, Javier AU - Brazo-Sayavera J AD - Department of Sports and Computer Science, Universidad Pablo de Olavide, Seville, Spain. FAU - Cortinez-O'Ryan, Andrea AU - Cortinez-O'Ryan A AD - Department of Physical Education, Sports and Recreation, Universidad de La Frontera, Temuco, Chile. AD - School of Kinesiology, Faculty of Medical Sciences, Universidad de Santiago de Chile, Chile. FAU - De Roia, Gabriela AU - De Roia G AD - Laboratorio de Estudios en Actividad Fisica (LEAF), Universidad de Flores, CABA, Argentina. FAU - Gonzalez, Silvia A AU - Gonzalez SA AD - School of Medicine, Universidad de los Andes, Bogota, Colombia. FAU - Guisihan, Roselle M AU - Guisihan RM AD - Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila City, Philippines. FAU - Jeon, Justin Y AU - Jeon JY AD - Department of Sport Industry Studies, Center for Exercise Medicine and Salutogenesis, Yonsei University, Seoul, South Korea. FAU - Kim, Yeon Soo AU - Kim YS AD - Department of Physical Education, Institute of Sports Science, Seoul National University, Seoul, South Korea. FAU - Poh, Bee Koon AU - Poh BK AD - Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Slancova, Terezia Kovalik AU - Slancova TK AD - University of Presov, Faculty of Sports, Presov, Slovakia. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco, Chile. FAU - Ng, Kwok AU - Ng K AD - Physical Activity for Health Research Centre, Health Research Institute & Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland. AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. AD - Department of Teacher Education, Turku Institute of Advanced Studies, University of Turku, Turku, Finland. FAU - Palad, Yves AU - Palad Y AD - Department of Physical Therapy, College of Allied Medical Professions, University of the Philippines, Manila, Philippines. FAU - Silva, Diego Augusto Santos AU - Silva DAS AD - Department of Physical Education, Sports Center, Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Tomaz, Simone A AU - Tomaz SA AD - Faculty of Health Sciences and Sport, University of Stirling, Stirling, Scotland, UK. FAU - Urbanski, Piotr Kazimierz AU - Urbanski PK AD - Department of Adapted Physical Activity, Poznan University of Physical Education, Poznan, Poland. FAU - Tremblay, Mark S AU - Tremblay MS AD - Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Department of Health Sciences, Carleton University, Ottawa, ON, Canada. AD - Active Healthy Kids Global Alliance, Ottawa, ON, Canada. AD - Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada. LA - eng PT - Journal Article DEP - 20260905 PL - Singapore TA - J Exerc Sci Fit JT - Journal of exercise science and fitness JID - 101198241 PMC - PMC13583972 OTO - NOTNLM OT - International benchmarking OT - Measurement OT - Policy OT - Youth COIS- ID was an AHKGA Fellow, and SA, JBS, DASS, and MST were members of the AHKGA Board of Directors during the conduct of this study. LCE and MW were part of the expert team that developed the Welsh approach. All other authors declare no competing interests. EDAT- 2026/09/18 12:26 MHDA- 2026/09/18 12:27 PMCR- 2026/09/05 CRDT- 2026/09/18 07:40 PHST- 2026/05/03 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/18 12:27 [medline] PHST- 2026/09/18 12:26 [pubmed] PHST- 2026/09/18 07:40 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - S1728-869X(26)00081-X [pii] AID - 200520 [pii] AID - 10.1016/j.jesf.2026.200520 [doi] PST - ppublish SO - J Exerc Sci Fit. 2026 Oct;24(4):200520. doi: 10.1016/j.jesf.2026.200520. Epub 2026 Sep 5. PMID- 42756357 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 9 DP - 2026 Sep TI - Identification of Antileukemic Compound From Ginger by Integrating UHPLC-MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro and In Vivo Experimental Validation. PG - e72379 LID - 10.1002/fsn3.72379 [doi] LID - e72379 AB - Acute myeloid leukemia (AML) is a prevalent pediatric hematologic malignancy associated with a poor clinical prognosis, largely due to drug-induced toxicity, the emergence of resistance, and frequent disease relapse. Edible plants offer promising complementary therapeutic approaches through their bioactive compounds, which are characterized by favorable safety profiles. Zingiber officinale (ginger), commonly consumed both as a dietary component and as a traditional medicinal herb, has garnered increasing scientific interest; however, its potential antileukemic properties remain largely unexplored. Crude extracts from four ginger cultivars exhibited antileukemic activity in AML cells. Metabolomic profiling was used to screen for candidate constituents, and Arctigenin was selected for further investigation. Its presence in the ginger extracts was verified by targeted UHPLC-MS analysis using an authentic standard, followed by evaluation of its antileukemic activity. Arctigenin showed potent and selective cytotoxicity against AML cells, particularly HL60 cells. Network pharmacology was employed to predict potential molecular targets, followed by molecular docking and 100-ns molecular dynamics simulations to evaluate potential interactions, suggesting PARP1 and NFkappaB1 as potential molecular targets. Experimental analyses further demonstrated that Arctigenin induced apoptosis and altered NFkappaB and PARP protein expression in AML cells. In vivo experiments demonstrated that Arctigenin significantly suppressed tumor growth in an AML xenograft mouse model, achieving efficacy comparable to that of cytarabine, without inducing hepatosplenic toxicity or metabolic disturbances. These findings provide the first evidence supporting ginger as a novel phytochemical resource for AML therapy and support Arctigenin as a promising antileukemic candidate, underscoring its potential for incorporation into food-based or plant-derived therapeutic strategies. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Huang, Mengjun AU - Huang M AD - National-Local Joint Engineering Research Center for Innovative Targeted Drugs Chongqing University of Arts and Sciences Chongqing P. R. China. FAU - Liu, Jing AU - Liu J AD - Department of Pediatric Hematologic Oncology and Respiratory Children's Medical Center, The Affiliated Hospital, Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Southwest Medical University Luzhou Sichuan P. R. China. FAU - Zeng, Kaixuan AU - Zeng K AUID- ORCID: 0009-0002-0681-5588 AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. FAU - Xu, Lianling AU - Xu L AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. FAU - Liu, Yangchun AU - Liu Y AUID- ORCID: 0009-0006-4091-4829 AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. FAU - Xie, Linyun AU - Xie L AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. FAU - Shi, Mengni AU - Shi M AUID- ORCID: 0009-0007-1062-6209 AD - Department of Clinical Medicine, School of Clinical Medicine Southwest Medical University Luzhou Sichuan P. R. China. FAU - Zeng, Yan AU - Zeng Y AD - Department of Pediatric Hematologic Oncology and Respiratory Children's Medical Center, The Affiliated Hospital, Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Southwest Medical University Luzhou Sichuan P. R. China. FAU - Liu, Wenjun AU - Liu W AUID- ORCID: 0000-0002-7205-0598 AD - Department of Pediatric Hematologic Oncology and Respiratory Children's Medical Center, The Affiliated Hospital, Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Southwest Medical University Luzhou Sichuan P. R. China. FAU - Guo, Ling AU - Guo L AUID- ORCID: 0000-0003-1986-3175 AD - Department of Pediatric Hematologic Oncology and Respiratory Children's Medical Center, The Affiliated Hospital, Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Southwest Medical University Luzhou Sichuan P. R. China. AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. LA - eng PT - Journal Article DEP - 20260916 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13583061 OTO - NOTNLM OT - acute myeloid leukemia OT - arctigenin OT - ginger OT - molecular dynamics simulation OT - network pharmacology COIS- The authors declare no conflicts of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/16 CRDT- 2026/09/18 07:15 PHST- 2025/12/31 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 07:15 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - FSN372379 [pii] AID - 10.1002/fsn3.72379 [doi] PST - epublish SO - Food Sci Nutr. 2026 Sep 16;14(9):e72379. doi: 10.1002/fsn3.72379. eCollection 2026 Sep. PMID- 42756176 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - Age-specific alterations in gut microbiota-plasma metabolome networks in first-episode, drug-naive major depressive disorder: adolescent versus adult patients. PG - 1922527 LID - 10.3389/fmicb.2026.1922527 [doi] LID - 1922527 AB - BACKGROUND: Major depressive disorder (MDD) exhibits pronounced age-related pathophysiological heterogeneity, yet the distinct signatures of the microbiota-gut-brain (MGB) axis between adolescent and adult patients remain inadequately characterized. This study aimed to elucidate age-specific MGB axis dysregulation by integrating gut microbiota profiling, plasma metabolomics, and their interactive networks in first-episode, drug-naive MDD patients across these two developmental stages. METHODS: We enrolled 62 first-episode, drug-naive MDD patients (28 adolescents, 34 adults) alongside 43 age- and sex-matched healthy controls (22 adolescents, 21 adults). Fecal samples underwent 16S rRNA gene sequencing, while plasma was analyzed via untargeted metabolomics. Comprehensive bioinformatics and network analyses were applied to map microbial compositional shifts, metabolic perturbations, and microbe-metabolite crosstalks. RESULTS: Integrated multi-omics analysis revealed distinct age-specific gut microbiota and plasma metabolome signatures in TMDD and AMDD compared with their age-matched controls. 1 in circle Microbiota: Beyond shared depletion of Firmicutes and butyrate-producing genera (Anaerobutyricum, Blautia), TMDD exhibited more extensive remodeling. Characterized by increased (Chao1 index, p < 0.05) Bifidobacterium loss and enrichment of Bacteroidetes, Gemmatimonadetes, and Planctomycetes. 2 in circle Metabolome: TMDD perturbations targeted neurodevelopmental and oxidative pathways, such as arginine/proline metabolism, D-amino acid metabolism, and glutathione metabolism. Whereas AMDD focused on energy dysfunction and excitotoxicity, involving the TCA cycle, purine metabolism, and alanine/aspartate/glutamate metabolism. 3 in circle Interactome: In AMDD, positive correlations with protective (lipids) were attenuated, while pathological links with pro-inflammatory sphingolipids and polyamines strengthened. The interactome in AMDD remained stable. CONCLUSION: Our findings suggest that first-episode, drug-naive MDD patients display distinct age-specific dysregulation of the microbiota-gut-plasma metabolome axis. The non-overlapping pathological signatures, a "development-nutrition-metabolic" disturbance pattern in adolescents versus an "energy metabolism-oxidative stress" pattern in adults, underscore the pronounced pathophysiological heterogeneity of MDD across the lifespan. These preliminary observations indicate that future diagnostic biomarkers and therapeutic interventions, particularly microbiota-targeted strategies, should be precisely tailored to the biological profiles of different age groups. However, given the exploratory nature of this subtyping, larger independent cohort studies are warranted to validate these findings before clinical translation. CI - Copyright (c) 2026 Mo, Chai, Zhao, Wang, Zhang, Miaoyang, Wang, Lu and Wang. FAU - Mo, Hui AU - Mo H AD - Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Chai, Dan AU - Chai D AD - Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Zhao, LeTian AU - Zhao L AD - Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Wang, Jun AU - Wang J AD - Department of Hygienic Analysis and Detection, Center for Global Health, Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Zhang, Qiang AU - Zhang Q AD - School of Automation and Intelligent Sensing, Shanghai Jiaotong University, Shanghai, China. FAU - Miaoyang, Hu AU - Miaoyang H AD - Department of Hygienic Analysis and Detection, Center for Global Health, Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Wang, Ting AU - Wang T AD - Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Lu, WeiMin AU - Lu W AD - Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Wang, Changqing AU - Wang C AD - Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC13582463 OTO - NOTNLM OT - age heterogeneity OT - gut microbiota OT - major depressive disorder OT - metabolomics OT - microbiota-gut-brain axis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/03 CRDT- 2026/09/18 06:52 PHST- 2026/06/30 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 06:52 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1922527 [doi] PST - epublish SO - Front Microbiol. 2026 Sep 3;17:1922527. doi: 10.3389/fmicb.2026.1922527. eCollection 2026. PMID- 42756134 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Beyond oxygen targets: the DOSE framework as a conceptual model for dynamic oxygen stewardship in retinopathy of prematurity. PG - 1882831 LID - 10.3389/fped.2026.1882831 [doi] LID - 1882831 AB - Retinopathy of prematurity (ROP) remains a major cause of preventable childhood blindness, and oxygen therapy continues to represent a central but complex component of neonatal care. Current oxygen management is largely guided by static peripheral oxygen saturation (SpO(2)) target ranges, commonly around 90%-95%. However, target ranges alone may not fully capture the dynamic nature of oxygen exposure in preterm infants, including fluctuations, intermittent hypoxemia, hyperoxemic excursions, instability, and cumulative exposure over time. We propose the Dynamic Oxygen Stability and Exposure (DOSE) framework as a conceptual and hypothesis-generating model for dynamic oxygen stewardship in ROP prevention. DOSE integrates four interconnected domains: delivered oxygen input (dose), physiologic oxygenation output reflected by the SpO(2) response, oxygen stability or fluctuation control, and cumulative oxygen exposure over time. The novelty of DOSE does not lie in claiming that these individual elements are new, but in organizing them into a unified framework that may help explain why similar SpO(2) targets can produce different biologic oxygen experiences across infants and care settings. This framework does not replace existing oxygen saturation guidelines and is not yet a validated clinical score or predictive model. Rather, it provides a structured approach for future research, quality improvement, and prospective validation of dynamic oxygen-exposure metrics. DOSE also recognizes that ROP is multifactorial and that oxygen instability should be interpreted alongside prematurity severity, postnatal growth, inflammation, transfusion, nutrition, respiratory morbidity, screening access, and treatment availability. By shifting attention from static targets alone toward oxygen stability and cumulative exposure, DOSE may support future strategies for safer and more individualized oxygen stewardship in diverse neonatal settings. CI - (c) 2026 Siswanto. FAU - Siswanto, Johanes Edy AU - Siswanto JE AD - Department of Neonatology, Harapan Kita National Women and Children Health Centre, Jakarta, Indonesia. AD - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13582581 OTO - NOTNLM OT - DOSE framework OT - dynamic oxygen exposure OT - low- and middle-income countries OT - oxygen instability OT - oxygen saturation OT - oxygen stewardship OT - oxygen therapy OT - retinopathy of prematurity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/03 CRDT- 2026/09/18 06:49 PHST- 2026/05/16 00:00 [received] PHST- 2026/07/12 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 06:49 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fped.2026.1882831 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 3;14:1882831. doi: 10.3389/fped.2026.1882831. eCollection 2026. PMID- 42756052 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Physical activity and health-related quality of life among Chinese adolescents: a cross-sectional statistical path model involving sleep disturbance and depressive symptoms. PG - 1954434 LID - 10.3389/fped.2026.1954434 [doi] LID - 1954434 AB - OBJECTIVE: Physical activity (PA) is positively associated with health-related quality of life (HRQoL) in adolescents, while sleep disturbance and depressive symptoms are also closely related to both PA and HRQoL. However, relatively few studies have examined these factors simultaneously, particularly among Chinese adolescents. This study examined the association between PA and HRQoL and assessed the separate and serial indirect associations involving sleep disturbance and depressive symptoms. METHODS: A cross-sectional survey was conducted among 2,202 secondary-school students from 12 schools in China. Participants completed validated self-report measures of PA, sleep disturbance, depressive symptoms, and HRQoL. Pearson correlations were used to examine bivariate associations, and a serial multiple-mediator model (PROCESS Model 6) was applied to estimate direct and indirect associations. Statistical uncertainty was evaluated using 5,000 bootstrap resamples and bias-corrected 95% confidence intervals (CIs). RESULTS: Higher PA was associated with lower sleep disturbance and depressive symptoms and with better HRQoL. Sleep disturbance was positively associated with depressive symptoms, whereas both sleep disturbance and depressive symptoms were inversely associated with HRQoL. The standardized total association between PA and HRQoL was 0.324 [95% CI (0.288, 0.358)], of which 0.095 was statistically accounted for by the combined indirect associations. Significant specific indirect associations were observed through sleep disturbance alone [beta = 0.032, 95% CI (0.019, 0.046)], depressive symptoms alone [beta = 0.046, 95% CI (0.034, 0.058)], and the sequential pathway involving sleep disturbance followed by depressive symptoms [beta = 0.017, 95% CI (0.013, 0.022)]. The direct PA-HRQoL association remained significant after both statistical mediators were included [beta = 0.229, 95% CI (0.191, 0.265)]. CONCLUSIONS: PA, sleep disturbance, depressive symptoms, and HRQoL were closely interconnected among Chinese adolescents. Sleep- and mood-related factors statistically accounted for part of the positive association between PA and HRQoL, with depressive symptoms showing the largest specific indirect association. These findings support considering PA, sleep health, and emotional well-being within an integrated adolescent health framework. Because all variables were measured concurrently, the observed indirect associations should not be interpreted as evidence of temporal or causal mediation. CI - (c) 2026 Liu. FAU - Liu, Mengxuan AU - Liu M AD - School of Physical Education, Jiangxi Institute of Technology, Nanchang, China. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13582418 OTO - NOTNLM OT - China OT - adolescents OT - depressive symptoms OT - health-related quality of life OT - physical activity OT - sleep disturbance OT - statistical association COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/03 CRDT- 2026/09/18 06:37 PHST- 2026/07/31 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 06:37 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fped.2026.1954434 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 3;14:1954434. doi: 10.3389/fped.2026.1954434. eCollection 2026. PMID- 42755577 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Predicting extrauterine growth restriction at the parenteral-enteral nutrition transition: a model for risk identification in very preterm infants. PG - 1788647 LID - 10.3389/fnut.2026.1788647 [doi] LID - 1788647 AB - INTRODUCTION: This study aims to identify the key predictors of longitudinal extrauterine growth restriction (EUGR) in very preterm infants during the parenteral-to-enteral nutrition transition and subsequently develop an effective predictive model for early clinical identification. METHODS: A total of 260 infants born at 28-31(+6) weeks of gestation were included in this retrospective study. Perinatal and early postnatal clinical data were collected. The univariate regression analysis (p < 0.1) and LASSO algorithms were employed to comprehensively screen for variables. The screened variables were utilized to construct the optimal model. The development of an optimal predictive model involved performance comparison and validation across five algorithms, including logistic regression and four machine learning algorithms. This process was coupled with an explanation of machine learning algorithms using the Shapley Additive exPlanations (SHAP) to ensure interpretability. RESULTS: The study identified six key predictors: gestational age, sex, time to regain birth weight, gestational diabetes, hypertensive disorders of pregnancy and blood urea nitrogen. Among the models compared, the logistic regression model exhibited the best performance, and the nomogram developed from this model demonstrated strong predictive efficacy. CONCLUSION: In this study, we developed and internally validated a prediction model for longitudinal EUGR in very preterm infants specifically during the parenteral-to-enteral transition. The model demonstrated robust predictive performance, strong clinical utility, and exceptional interpretability. It offers a practical tool for risk stratification during the parenteral-to-enteral transition, enabling clinicians to identify high-risk infants who may benefit from timely, personalized nutritional support. CI - Copyright (c) 2026 Wu, Zhou, Hu, Chen, Huang, Zhang and Xiu. FAU - Wu, Zhenyuan AU - Wu Z AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Zhou, Dan AU - Zhou D AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Hu, Yanhua AU - Hu Y AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Chen, Rong AU - Chen R AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Huang, Min AU - Huang M AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Zhang, Baoquan AU - Zhang B AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Xiu, Wenlong AU - Xiu W AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13581580 OTO - NOTNLM OT - Fenton 2013 OT - logistic regression OT - machine learning OT - restricted growth OT - very preterm COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/03 CRDT- 2026/09/18 05:22 PHST- 2026/01/15 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 05:22 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fnut.2026.1788647 [doi] PST - epublish SO - Front Nutr. 2026 Sep 3;13:1788647. doi: 10.3389/fnut.2026.1788647. eCollection 2026. PMID- 42754870 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260922 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 Sep 11 TI - Effectiveness of structured lactation support and human donor milk banking in German NICUs: a stepped-wedge cluster-randomized trial. LID - 10.1186/s12916-026-05211-1 [doi] LID - 504 AB - BACKGROUND: Although exclusive human milk feeding is beneficial for very low birth weight infants, rates remain suboptimal globally. This hybrid type 1 effectiveness-implementation trial evaluated structured lactation support combined with human donor milk banking in neonatal intensive care units (NICUs), primarily assessing effectiveness, with secondary assessment of implementation and economic outcomes. METHODS: We conducted a stepped-wedge cluster-randomized trial in 15 German Level I NICUs (April 2022-March 2024). The Neo-MILK intervention comprised structured lactation counselling, multilingual materials, mobile app support for mothers/parents, and human donor milk banking. Implementation strategies included video-based staff training, guidelines, commitment nudges for medical staff, and support for human donor milk bank establishment. The primary outcome was exclusive mother's own milk feeding at NICU discharge. Secondary outcomes included feeding status categories, clinical complications, length of stay, and maternal outcomes. Implementation outcomes were acceptability, feasibility, appropriateness, fidelity, and sustainability. Prespecified subgroup analyses examined birth weight (< 1,000 g vs. >/=1,000 g) and illness severity (CRIB >/= 11 vs. <11). Economic evaluation employed time-driven activity-based costing and budget impact analysis. RESULTS: Among 1,627 very low birth weight infants (831 intervention, 796 control), the intervention increased exclusive mother's own milk feeding at discharge by 11%-points (95% CI: 3.0 to 19.0; p = 0.007) from a 43% baseline. Exclusive formula feeding decreased correspondingly. Subgroup analyses showed no significant effects in extremely low birth weight infants (< 1,000 g) or high-risk infants (CRIB >/= 11). Clinical complications and length of stay showed no differences. Acceptability, appropriateness, and feasibility were high. Fidelity was sufficient, with prepartal counselling delivered as intended in 71% of cases. Human donor milk banks were established in 40% of sites. Sustainability indicators were promising, with 61% of staff reporting routine integration. Economic evaluation suggested potential net savings nationally in the base-case scenario. CONCLUSIONS: Structured lactation support with human donor milk banking increased exclusive mother's own milk feeding across Level I NICUs, with no observed increase in complications or costs. Implementation appeared feasible, with indications of sustainability. Variable uptake and differential effects in highest-risk subgroups highlight the need for ongoing organizational support and tailored strategies to further optimize effectiveness. CLINICAL TRIAL REGISTRATION: German Clinical Trials Register DRKS00025058. CI - (c) 2026. The Author(s). FAU - Koberlein-Neu, Juliane AU - Koberlein-Neu J AUID- ORCID: 0000-0002-3451-7847 AD - Centre for Health Economics and Health Services Research, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany. koeberlein@wiwi.uni-wuppertal.de. FAU - Dymek, Nicola Gabriela AU - Dymek NG AUID- ORCID: 0009-0005-3594-2617 AD - Centre for Health Economics and Health Services Research, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany. FAU - Zimmer, Viola AU - Zimmer V AUID- ORCID: 0009-0008-0580-2463 AD - Centre for Health Economics and Health Services Research, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany. FAU - Bommhardt, Trutz AU - Bommhardt T AUID- ORCID: 0009-0007-1748-1073 AD - Centre for Health Economics and Health Services Research, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany. FAU - Stirner, Anna Katharina AU - Stirner AK AUID- ORCID: 0009-0005-0429-9112 AD - Department of Business Administration and Health Care Management, University of Cologne, Cologne, Germany. FAU - Guldenring, Isabella AU - Guldenring I AUID- ORCID: 0000-0003-0476-2814 AD - Department for Psychosomatic Medicine and Psychotherapy, Centre for Health Services Research and Communication (CHSR), University Hospital Bonn, Bonn, Germany. FAU - Ohnhauser, Tim AU - Ohnhauser T AD - Faculty of Medicine and University Hospital Cologne, Institute of Medical Sociology, Health Services Research and Rehabilitation Science, Chair of Health Services Research, University of Cologne, Cologne, Germany. FAU - Wiesen, Daniel AU - Wiesen D AUID- ORCID: 0000-0003-4627-1730 AD - Department of Business Administration and Health Care Management, University of Cologne, Cologne, Germany. AD - Erasmus School of Health Policy and Management (ESHPM), Erasmus University Rotterdam, Rotterdam, Netherlands. FAU - Dresbach, Till AU - Dresbach T AUID- ORCID: 0000-0001-7074-7933 AD - Department of Neonatology, University Hospital Bonn, Bonn, Germany. FAU - Scholten, Nadine AU - Scholten N AUID- ORCID: 0000-0002-7793-7745 AD - Department for Psychosomatic Medicine and Psychotherapy, Centre for Health Services Research and Communication (CHSR), University Hospital Bonn, Bonn, Germany. AD - Faculty of Medicine and University Hospital Cologne, Institute of Medical Sociology, Health Services Research and Rehabilitation Science, Chair of Health Services Research, University of Cologne, Cologne, Germany. CN - Neo-MILK Consortium/collaborators LA - eng SI - DRKS/6 May 2021 -DRKS-00025058 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20260911 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 SB - IM MH - Humans MH - *Milk Banks MH - *Intensive Care Units, Neonatal MH - Germany MH - Female MH - Infant, Newborn MH - *Milk, Human MH - *Lactation MH - *Breast Feeding MH - Adult MH - Infant, Very Low Birth Weight MH - Male PMC - PMC13587408 OTO - NOTNLM OT - Human donor milk OT - Hybrid effectiveness-implementation trial OT - Lactation support OT - Mother's own milk feeding OT - Neonatal care OT - Stepped-wedge cluster-randomized trial OT - Very low birth weight infants COIS- Declarations. Ethics approval and consent to participate: This study has received ethical approval from the Ethics Committee of the Medical Faculty of the University of Cologne (No. 21-1506), the Ethics Committee of the University of Wuppertal (No. 211007) and the local ethics committees of the participating NICUs (without ID). Mothers and NICU staff were given information regarding the study and the data collection, were informed about the voluntary nature, confidentiality, and the possibility of withdrawing at any point. Written consent was obtained from all participants (mothers and NICU staff) before data collection via surveys and qualitative methods. Primary outcome data were extracted from routine medical records under ethics approval, which waived individual consent for anonymized clinical data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/18 05:36 MHDA- 2026/09/18 05:37 PMCR- 2026/09/11 CRDT- 2026/09/18 00:12 PHST- 2026/03/04 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/18 05:37 [medline] PHST- 2026/09/18 05:36 [pubmed] PHST- 2026/09/18 00:12 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.1186/s12916-026-05211-1 [pii] AID - 5211 [pii] AID - 10.1186/s12916-026-05211-1 [doi] PST - epublish SO - BMC Med. 2026 Sep 11;24(1):504. doi: 10.1186/s12916-026-05211-1. PMID- 42754274 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260925 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 17 TI - Semaglutide as adjunct treatment for obesity in adolescents receiving antipsychotic medication (the GOAL trial): protocol for a single-arm, open-label feasibility study. PG - e123779 LID - 10.1136/bmjopen-2026-123779 [doi] LID - e123779 AB - INTRODUCTION: Adolescents treated with antipsychotic medication are at increased risk of obesity and metabolic complications, yet evidence-based interventions in this group remain limited. Glucagon-like peptide-1 receptor agonists have demonstrated efficacy in the treatment of obesity in both adults and adolescents. The aim of this trial is to assess the feasibility of a 36-week treatment period with a glucagon-like peptide-1 receptor agonist as an adjunct to standard care in adolescents with antipsychotic-associated obesity, defined as completion from baseline to end of treatment. The findings from this feasibility trial will inform the design and support the scale-up of a subsequent randomised controlled trial. METHODS AND ANALYSIS: The GOAL trial is a single-arm, open-label feasibility study conducted at Copenhagen University Hospital, Bispebjerg, Denmark, in collaboration with the Child and Adolescent Mental Health Center. A total of 34 adolescents aged 12-18 years with obesity, defined as body mass index SD score equal to or greater than +1.28 and body fat percentage at or above the 95th percentile, receiving stable antipsychotic treatment will be enrolled. The study population includes adolescents with a range of psychiatric diagnoses requiring antipsychotic treatment, including psychotic disorders, mood disorders and neurodevelopmental disorders. Adolescents receiving antipsychotic treatment under coercion are excluded. Participants will receive once-weekly subcutaneous semaglutide at a dose up to 2.4 milligrams for 36 weeks in addition to standard care, followed by an 18-month observational follow-up period. The primary outcome is study completion rate. Additional feasibility outcomes include recruitment rate, treatment adherence and completion of study procedures. Secondary outcomes include changes in body mass index SD score, body composition, metabolic biomarkers and psychiatric outcomes. Feasibility outcomes will be analysed descriptively. Exploratory longitudinal analyses will be conducted using linear mixed-effects models. ETHICS AND DISSEMINATION: The study complies with the Declaration of Helsinki and European Union Clinical Trials Regulation (536/2014) and is approved in the Clinical Trials Information System (2024-5 17 471-21-02). Written informed consent will be obtained from participants and their legal guardians. Results will be disseminated through peer-reviewed publications and scientific conferences. TRIAL REGISTRATION NUMBER: 2024-5 17 471-21-02. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Giraldi, Laura Victoria AU - Giraldi LV AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Andersen, Jon Traerup AU - Andersen JT AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Jespersen, Jonas AU - Jespersen J AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Baden, Christoffer Storm AU - Baden CS AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Fonvig, Cilius Esmann AU - Fonvig CE AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital, Holbaek, Denmark. FAU - Riis, Troels AU - Riis T AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Dalhoff, Kim Peder AU - Dalhoff KP AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Holm, Jens-Christian AU - Holm JC AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital, Holbaek, Denmark. FAU - Fink-Jensen, Anders AU - Fink-Jensen A AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Psychiatric Center Copenhagen, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Pagsberg, Anne Katrine AU - Pagsberg AK AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Child- and adolescent mental health center Research Unit, Gentofte, Capital Region Mental Health Services, Copenhagen, Denmark. FAU - Christensen, Mikkel Bring AU - Christensen MB AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Gade, Christina AU - Gade C AUID- ORCID: 0000-0002-0007-6158 AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark christina.gade@regionh.dk. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260917 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Antipsychotic Agents) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 53AXN4NNHX (Semaglutide) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Antipsychotic Agents/administration & dosage MH - Body Mass Index MH - Denmark MH - Feasibility Studies MH - *Glucagon-Like Peptide-1 Receptor Agonists/administration & dosage MH - Mental Disorders/drug therapy MH - *Pediatric Obesity/drug therapy/chemically induced MH - Semaglutide MH - Observational Studies as Topic PMC - PMC13599909 OTO - NOTNLM OT - Adolescent OT - Body Mass Index OT - Child & adolescent psychiatry OT - Clinical Protocols OT - Clinical Trial COIS- Competing interests: None declared. EDAT- 2026/09/17 23:34 MHDA- 2026/09/17 23:35 PMCR- 2026/09/17 CRDT- 2026/09/17 20:42 PHST- 2026/09/17 23:35 [medline] PHST- 2026/09/17 23:34 [pubmed] PHST- 2026/09/17 20:42 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - bmjopen-2026-123779 [pii] AID - 10.1136/bmjopen-2026-123779 [doi] PST - epublish SO - BMJ Open. 2026 Sep 17;16(9):e123779. doi: 10.1136/bmjopen-2026-123779. PMID- 42753886 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1872-6240 (Electronic) IS - 0006-8993 (Linking) VI - 1892 DP - 2026 Dec 1 TI - EEG neurofeedback for children with overweight and obesity: A proof-of-concept study. PG - 150554 LID - S0006-8993(26)00416-6 [pii] LID - 10.1016/j.brainres.2026.150554 [doi] AB - OBJECTIVE: Current treatment options for childhood overweight and obesity do not sufficiently address underlying neurophysiological disturbances, such as deviations in electroencephalography (EEG)-measured brain activity, which may account for weight loss failure. Therefore, the present proof-of-concept study estimated effects of food-cue based EEG neurofeedback for reducing high beta band activity in 8-14-year-old children with overweight/obesity (OO). As secondary outcomes, eating disorder psychopathology, food preferences, self-regulation, quality of life, body mass index, feasibility and acceptance were analyzed. METHODS: Children with OO (N = 20) were offered 10 sessions of EEG neurofeedback over 6 weeks. Assessments prior and after the end of treatment included interview-based, self- and parent-report measures as well as objective anthropometrics. RESULTS: EEG neurofeedback resulted in a less than small-sized reduction of food-specific high beta band activity pre- vs. post-intervention. Small effects on the reduction of children's standardized body mass index, external eating behavior, and medium to large effects for overeating were documented. Feasibility and acceptance were provided. CONCLUSION: Promising results of the present proof-of-concept study indicate the need for further in-depth research with larger samples, adequate control groups, and randomized design. SIGNIFICANCE: Potentially, EEG neurofeedback is a valuable, resource-efficient addition to standard treatment options for childhood obesity. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Hahn, Ulrike AU - Hahn U AD - University of Leipzig Medical Center, Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Philipp-Rosenthal-Strasse 55, D-04103 Leipzig, Germany. Electronic address: ulrikeh@posteo.de. FAU - Hubner, Claudia AU - Hubner C AD - University of Leipzig Medical Center, Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Philipp-Rosenthal-Strasse 55, D-04103 Leipzig, Germany. FAU - Hilbert, Anja AU - Hilbert A AD - University of Leipzig Medical Center, Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Philipp-Rosenthal-Strasse 55, D-04103 Leipzig, Germany; German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. FAU - Schmidt, Ricarda AU - Schmidt R AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany; Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital Leipzig, Leipzig, Germany. LA - eng PT - Journal Article DEP - 20260917 PL - Netherlands TA - Brain Res JT - Brain research JID - 0045503 SB - IM MH - Humans MH - *Neurofeedback/methods MH - Child MH - Male MH - Female MH - Electroencephalography/methods MH - Proof of Concept Study MH - Adolescent MH - *Overweight/therapy/physiopathology MH - Body Mass Index MH - *Pediatric Obesity/therapy/physiopathology MH - Brain/physiopathology MH - Beta Rhythm/physiology MH - Obesity MH - Feeding Behavior/physiology MH - Quality of Life MH - Treatment Outcome OTO - NOTNLM OT - Childhood obesity OT - EEG neurofeedback OT - Frequency bands OT - Intervention OT - Neuromodulation OT - Self-regulation COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/17 23:34 MHDA- 2026/10/29 05:30 CRDT- 2026/09/17 19:13 PHST- 2026/02/16 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/09/17 23:34 [pubmed] PHST- 2026/10/29 05:30 [medline] PHST- 2026/09/17 19:13 [entrez] AID - S0006-8993(26)00416-6 [pii] AID - 10.1016/j.brainres.2026.150554 [doi] PST - ppublish SO - Brain Res. 2026 Dec 1;1892:150554. doi: 10.1016/j.brainres.2026.150554. Epub 2026 Sep 17. PMID- 42753269 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1715-5320 (Electronic) IS - 1715-5312 (Linking) VI - 51 DP - 2026 Jan 1 TI - Low energy availability and female athlete Triad risk in Black collegiate track and field athletes. PG - 1-9 LID - 10.1139/apnm-2026-0036 [doi] AB - This study evaluated energy availability, menstrual function, bone mineral density (BMD), and female athlete Triad (Triad) risk among Black collegiate female track and field athletes. Study participants were female athletes (n = 18) on the track and field team at a Historically Black College/University. Energy intake and expenditure were estimated using an 8-day doubly labeled water protocol. Body composition was measured using dual-energy X-ray absorptiometry. Energy availability (EA) was calculated as (energy intake - activity energy expenditure)/fat free mass (FFM). Triad risk was assessed using female athlete Triad cumulative risk assessment. Survey responses captured eating behaviors, menstrual history, and food security status. Among these athletes, 56% exhibited EA below 45 kcal/kgFFM/day, and 17% were classified with clinical low energy availability (LEA) (<30 kcal/kgFFM/day). Forty-four percent of athletes met criteria for moderate Triad risk, though none were at high risk and none met criteria for low BMD. EA was inversely associated with body mass index (BMI) (r = -0.48, p = 0.04). Athletes reporting disordered/binge eating had significantly lower EA (p = 0.02). Food insecurity was identified among 22% of the study population but was not significantly associated with LEA or Triad risk. Over half of the Black female collegiate track and field athletes exhibited LEA, with nearly half meeting criteria for moderate Triad risk despite normal BMD and BMI. These findings highlight the need for routine screening and tailored interventions addressing LEA, menstrual dysfunction, and disordered eating in underrepresented athlete populations. ClinicalTrials.gov Identifier: NCT07631312. FAU - Taylor, Altelisha L AU - Taylor A AD - Department of Family Medicine, Morehouse School of Medicine, Atlanta, GA, USA. FAU - Moore, Carla J AU - Moore C AD - Clinical Research Center, Morehouse School of Medicine, Atlanta, GA, USA. RINGGOLD: 1374 FAU - Barrack, Michelle T AU - Barrack M AUID- ORCID: 0000-0003-0897-1832 AD - Department of Family and Consumer Sciences, California State University, Long Beach, Long Beach, CA, USA. RINGGOLD: 14668 LA - eng SI - ClinicalTrials.gov/NCT07631312 PT - Journal Article PL - Canada TA - Appl Physiol Nutr Metab JT - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JID - 101264333 SB - IM MH - Humans MH - Female MH - *Female Athlete Triad Syndrome/epidemiology/etiology MH - *Energy Intake MH - Bone Density MH - Energy Metabolism MH - *Athletes MH - Young Adult MH - *Track and Field MH - *Black or African American MH - Body Composition MH - Risk Factors MH - Adolescent MH - Body Mass Index MH - Relative Energy Deficiency in Sport MH - Absorptiometry, Photon MH - Historically Black Colleges and Universities OTO - NOTNLM OT - bone mineral density OT - energy deficiency OT - food insecurity OT - menstrual function COIS- The authors declare there are no competing interests. EDAT- 2026/09/17 23:34 MHDA- 2026/10/28 11:34 CRDT- 2026/09/17 17:42 PHST- 2026/10/28 11:34 [medline] PHST- 2026/09/17 23:34 [pubmed] PHST- 2026/09/17 17:42 [entrez] AID - 10.1139/apnm-2026-0036 [doi] PST - ppublish SO - Appl Physiol Nutr Metab. 2026 Jan 1;51:1-9. doi: 10.1139/apnm-2026-0036. PMID- 42753249 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260925 IS - 2561-1011 (Electronic) IS - 2561-1011 (Linking) VI - 10 DP - 2026 Sep 17 TI - Improving Cardiometabolic Health in Adolescent Girls With Elevated Anxiety: Web-Based Multisite, Pilot, and Feasibility Randomized Controlled Trial. PG - e82781 LID - 10.2196/82781 [doi] LID - e82781 AB - BACKGROUND: Anxiety is common in adolescents with elevated BMI (kg/m(2)), affecting 33%-43% of adolescents with overweight or obesity (age- and sex-specific BMI >/=85th percentile ). Anxiety has been associated with poorer cardiometabolic health, and disinhibited eating in response to anxiety may be a key explanatory mechanism. Therefore, reducing anxiety in adolescents may improve disinhibited eating patterns and prevent worsening cardiometabolic health. OBJECTIVE: This pilot study primarily aimed to assess the feasibility and acceptability of 2 virtual group psychological interventions, interpersonal psychotherapy (IPT) and cognitive behavioral therapy (CBT), in adolescent girls with elevated anxiety and above-average weight. Secondary aims were to describe changes in anxiety, eating behavior, and cardiometabolic health indices. METHODS: This 2-site, 2-year, pilot and feasibility randomized controlled trial enrolled 12- to 17-year-old girls with elevated anxiety symptoms (State-Trait Anxiety Inventory for Children total score >/=32) and above-average weight (BMI >/=75th percentile for age and sex), who were in good general health and not concurrently receiving therapy or medication treatment. Girls were randomly assigned to 1 of 2 web-based arms: 12-week, psychologist-led, group IPT or CBT. In both arms, groups of 5-7 adolescents met for 90 minutes on secure Zoom (Zoom Communications, Inc) once per week. Anxiety, disinhibited eating, BMI indices, blood pressure, lipids, hemoglobin A(1c) (HbA(1c)), and fasting glucose were measured at baseline, 12-week follow-up, and 1-year follow-up. Feasibility of recruitment, retention, and study protocol, and acceptability and fidelity of IPT and CBT were evaluated. RESULTS: Of 47 eligible adolescents, 40 (85%) enrolled. Enrollment of the total sample (n=40) was completed in 7 months. Retention was 85% (n=17) in IPT and 100% (n=20) in CBT at 12-week follow-up. Protocol adherence exceeded 96% for all intervals. Missing data varied, with higher rates for phlebotomy (up to 30%). Acceptability ratings were above-average for likability (mean 3.03, SD 1.14) and credibility (mean 3.26, SD 0.75; 0-4 scale with 4=Highest) across arms. Most adolescents received >/=80% intervention dosage (IPT: 90%, CBT: 95%). Expert fidelity ratings of IPT were 78% (SD 11%) and CBT were 94% (SD 9%). From baseline to 1-year, IPT demonstrated improvements in general anxiety (95% CI -8.95 to -1.40), social anxiety (95% CI -12.37 to -1.88), and HbA(1c) (95% CI -0.48 to -0.23); CBT demonstrated improvement in emotional eating (95% CI -1.18 to -0.18), and both arms demonstrated improvements in BMI percentile (effect sizes=-0.82 and -0.63, IPT and CBT, respectively). CONCLUSIONS: This pilot and feasibility trial provided initial support for the feasibility of recruitment and retention and acceptability of web-based group IPT and CBT, as well as yielded areas for optimizing protocol feasibility and intervention fidelity. These preliminary results inform the planning of larger-scale efficacy trials with powered samples to assess effects on BMI and cardiometabolic health indicators among adolescents with elevated anxiety and above-average weight. CI - (c) Caitlin Edwards, LIsa Ranzenhofer, Jason Lavender, Lauren D Gulley, Stephen Aichele, Isabel Thorstad, Natalia Sanchez, Ruby Schrag, Zoe Sinkford, Jill Emerick, Victoria Thomas, Thomas Arnold, Jami Young, Denise Wilfley, Mark Haigney, Lauren Shomaker, Marian Tanofsky-Kraff. Originally published in JMIR Cardio (https://cardio.jmir.org). FAU - Edwards, Caitlin AU - Edwards C AUID- ORCID: 0000-0001-7576-0483 AD - Department of Human Development and Family Studies, College of Health and Human Services, Colorado State University, 410 W. Pitkin St, 1570 Campus Delivery, Fort Collins, CO, 80523, United States, 1 970-491-3217. AD - Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, United States. FAU - Ranzenhofer, Lisa AU - Ranzenhofer L AUID- ORCID: 0000-0002-7199-6998 AD - Department of Psychiatry, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States. FAU - Lavender, Jason AU - Lavender J AUID- ORCID: 0000-0001-9853-2280 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. AD - The Metis Foundation, San Antonio, TX, United States. FAU - Gulley, Lauren D AU - Gulley LD AUID- ORCID: 0000-0002-3868-8096 AD - Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, United States. AD - University of Colorado Anschutz Medical Campus, 6Barbara Davis Center for Diabetes, Aurora, CO, United States. FAU - Aichele, Stephen AU - Aichele S AUID- ORCID: 0000-0002-3397-7921 AD - Department of Human Development and Family Studies, College of Health and Human Services, Colorado State University, 410 W. Pitkin St, 1570 Campus Delivery, Fort Collins, CO, 80523, United States, 1 970-491-3217. FAU - Thorstad, Isabel AU - Thorstad I AUID- ORCID: 0009-0005-7710-0186 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Sanchez, Natalia AU - Sanchez N AUID- ORCID: 0000-0001-7929-4029 AD - Department of Human Development and Family Studies, College of Health and Human Services, Colorado State University, 410 W. Pitkin St, 1570 Campus Delivery, Fort Collins, CO, 80523, United States, 1 970-491-3217. FAU - Schrag, Ruby AU - Schrag R AUID- ORCID: 0009-0001-5691-4659 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Sinkford, Zoe AU - Sinkford Z AUID- ORCID: 0009-0008-4359-4271 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Emerick, Jill AU - Emerick J AUID- ORCID: 0000-0002-1839-8980 AD - Department of Pediatrics, Uniformed Services University, Bethesda, MD, United States. FAU - Thomas, Victoria AU - Thomas V AUID- ORCID: 0009-0003-6480-9394 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Arnold, Thomas AU - Arnold T AUID- ORCID: 0009-0003-9665-4518 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Young, Jami AU - Young J AUID- ORCID: 0000-0002-7488-5097 AD - Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States. FAU - Wilfley, Denise AU - Wilfley D AUID- ORCID: 0000-0002-3599-8689 AD - Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States. FAU - Haigney, Mark AU - Haigney M AUID- ORCID: 0000-0001-6449-4386 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Shomaker, Lauren AU - Shomaker L AUID- ORCID: 0000-0002-6129-8707 AD - Department of Human Development and Family Studies, College of Health and Human Services, Colorado State University, 410 W. Pitkin St, 1570 Campus Delivery, Fort Collins, CO, 80523, United States, 1 970-491-3217. AD - Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, United States. FAU - Tanofsky-Kraff, Marian AU - Tanofsky-Kraff M AUID- ORCID: 0000-0003-3871-2233 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. AD - Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, MD, United States. LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20260917 PL - Canada TA - JMIR Cardio JT - JMIR cardio JID - 101718325 SB - IM MH - Humans MH - Female MH - Adolescent MH - Pilot Projects MH - Feasibility Studies MH - *Anxiety/therapy/psychology MH - *Cognitive Behavioral Therapy/methods MH - Child MH - Body Mass Index PMC - PMC13585365 OTO - NOTNLM OT - adolescents OT - anxiety OT - cardiometabolic health OT - cognitive behavioral therapy OT - eating behaviors OT - feasibility OT - interpersonal psychotherapy OT - pilot trial COIS- Conflicts of Interest: None declared. EDAT- 2026/09/17 18:32 MHDA- 2026/09/17 18:33 PMCR- 2026/09/17 CRDT- 2026/09/17 16:29 PHST- 2025/08/21 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/17 18:33 [medline] PHST- 2026/09/17 18:32 [pubmed] PHST- 2026/09/17 16:29 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - v10i1e82781 [pii] AID - 82781 [pii] AID - 10.2196/82781 [doi] PST - epublish SO - JMIR Cardio. 2026 Sep 17;10:e82781. doi: 10.2196/82781. PMID- 42752631 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260922 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 9 DP - 2026 TI - Machine learning and deep learning-based prediction of hypertension and analysis of its major risk factors in Bangladesh. PG - e0358471 LID - 10.1371/journal.pone.0358471 [doi] LID - e0358471 AB - BACKGROUND: Hypertension is a leading cause of cardiovascular morbidity and mortality in Bangladesh. This study examined its prevalence, risk factors, and predictive modeling using machine learning (ML) and deep learning (DL) approaches. METHOD: We analyzed cross-sectional data from the 2022 Bangladesh Demographic and Health Survey, which included 14,283 adults (>/=18 years). Prevalence was estimated, chi-square tests assessed associations, and four ML models (weighted logistic regression, random forest, extreme gradient boosting, light gradient boosting machine) and two DL models (TabNet, and multi-layer perceptron) were applied to predict hypertension risk. Model performance was evaluated using accuracy, precision, recall, specificity, F1 score, and area under the receiver operating characteristics curve and precision-recall curve. RESULTS: Overall prevalence was 18.04% (95% CI: 17.2%-18.9%), higher among women (18.87%) than men (16.97%). The chi-square test suggests that hypertension was significantly associated with age, BMI, diabetes, wealth index, education, household size, and region (p < 0.05). Among the machine learning and deep learning models, weighted logistic regression (WLR) achieved the highest accuracy (0.817), precision (0.444), specificity (0.981), AUC-ROC (0.751), and AUC-PR (0.357). However, WLR exhibited low recall (0.070). In contrast, the random forest (RF) model achieved the highest recall (0.687) and F1-score (0.460) on the test data, indicating greater sensitivity in identifying individuals with hypertension. Additionally, age, BMI, sex, family size, and educational level were identified as the most important predictors among the variables included in the study. CONCLUSION: Hypertension is common in Bangladesh, with higher prevalence in women and significant association with socio-demographic determinants. Although WLR demonstrated the highest accuracy, precision, specificity, and AUC-PR, its low recall limits its utility for identifying individuals with hypertension. RF may be more suitable for public health applications because of its higher recall and F1-score; however, further external validation and assessment of its clinical utility are required before implementation. CI - Copyright: (c) 2026 Chandra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Chandra, Shawrab AU - Chandra S AD - Department of Statistics and Data Science, University of Barishal, Barishal, Bangladesh. FAU - Molla, Md Maeen AU - Molla MM AUID- ORCID: 0009-0000-9315-7338 AD - Department of Statistics, Pirojpur Science and Technology University, Pirojpur, Bangladesh. FAU - Islam, Samiul AU - Islam S AD - Department of Statistics and Data Science, University of Rajshahi, Rajshahi, Bangladesh. FAU - Rahaman, Md Matiur AU - Rahaman MM AUID- ORCID: 0000-0001-9799-9364 AD - Department of Statistics, Faculty of Science, Gopalganj Science and Technology University, Gopalganj, Bangladesh. FAU - Ali, Mohammad AU - Ali M AUID- ORCID: 0000-0002-0279-1972 AD - Statistics Discipline, Khulna University, Khulna, Bangladesh. FAU - Ali, Md Ayub AU - Ali MA AUID- ORCID: 0000-0002-5113-0054 AD - Department of Statistics and Data Science, University of Barishal, Barishal, Bangladesh. LA - eng PT - Journal Article DEP - 20260917 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - *Hypertension/epidemiology/diagnosis MH - Humans MH - Female MH - *Deep Learning MH - Bangladesh/epidemiology MH - Risk Factors MH - Male MH - Adult MH - Predictive Learning Models MH - Middle Aged MH - Random Forest MH - Cross-Sectional Studies MH - Prevalence MH - Boosting Machine Learning Algorithms MH - *Machine Learning MH - Prediction Algorithms MH - Young Adult MH - Adolescent MH - Classification Algorithms MH - Logistic Models MH - ROC Curve PMC - PMC13585235 COIS- The authors have declared that no competing interests exist. EDAT- 2026/09/17 18:32 MHDA- 2026/09/17 18:33 PMCR- 2026/09/17 CRDT- 2026/09/17 15:52 PHST- 2025/10/16 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/09/17 18:33 [medline] PHST- 2026/09/17 18:32 [pubmed] PHST- 2026/09/17 15:52 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - PONE-D-25-55897 [pii] AID - 10.1371/journal.pone.0358471 [doi] PST - epublish SO - PLoS One. 2026 Sep 17;21(9):e0358471. doi: 10.1371/journal.pone.0358471. eCollection 2026. PMID- 42752362 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20261009 IS - 1545-1151 (Electronic) IS - 1545-1151 (Linking) VI - 23 DP - 2026 Sep 17 TI - Transportation Walking Among US Adults With and Without Transportation Insecurity, 2022 National Health Interview Survey. PG - E43 LID - 10.5888/pcd23.250436 [doi] LID - E43 AB - INTRODUCTION: How Americans get to everyday destinations has implications for health and well-being. Transportation insecurity, or the lack of safe and convenient access to reliable transportation, is a public health problem that can lead to morbidity and mortality through injuries and chronic disease. Walking can be a healthy and low-cost mode of transportation. This study describes transportation walking among US adults with and without transportation insecurity. METHODS: We used 2022 National Health Interview Survey data on 25,889 US adults to estimate the prevalence of transportation walking among adults with and without transportation insecurity across sociodemographic and geographic subgroups. We tested subgroup differences using pairwise comparisons. RESULTS: In this sample, 5.6% (95% CI, 5.1%-6.2%) of US adults reported transportation insecurity. Walking for transportation was twice as common among adults with transportation insecurity (30.9%; 95% CI, 27.9%-34.1%) than among adults without transportation insecurity (15.3%; 95% CI, 14.5%-16.1%). Among adults with transportation insecurity, the prevalence of transportation walking was higher for adults with the lowest versus the highest levels of educational attainment, adults below versus above their poverty threshold, non-Hispanic Black versus non-Hispanic White adults, younger versus older adults, adults without versus adults with disabilities, and those residing in the West versus the South. CONCLUSION: About 1 in 6 US adults walk for transportation, but those with transportation insecurity are twice as likely to do so as those without. Infrastructure and policies that support walking can help improve the health and well-being of Americans and may be especially important for those experiencing transportation insecurity. FAU - Soto, Graycie AU - Soto G AD - McKing Consulting Corporation, Atlanta, Georgia. AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Van Dyke, Miriam E AU - Van Dyke ME AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Nakayama, Jasmine Y AU - Nakayama JY AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Chen, Tiffany J AU - Chen TJ AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Devlin, Heather M AU - Devlin HM AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Irani, Katherine AU - Irani K AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Matjasko, Jennifer L AU - Matjasko JL AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Zaganjor, Hatidza AU - Zaganjor H AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Whitfield, Geoffrey P AU - Whitfield GP AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. LA - eng PT - Journal Article DEP - 20260917 PL - United States TA - Prev Chronic Dis JT - Preventing chronic disease JID - 101205018 SB - IM MH - Humans MH - *Walking/statistics & numerical data MH - *Transportation/statistics & numerical data MH - United States MH - Adult MH - Female MH - Health Surveys MH - Middle Aged MH - Male MH - Young Adult MH - Adolescent MH - Aged MH - Socioeconomic Factors PMC - PMC13587706 EDAT- 2026/09/17 18:32 MHDA- 2026/09/17 18:33 PMCR- 2026/09/17 CRDT- 2026/09/17 15:38 PHST- 2026/09/17 18:33 [medline] PHST- 2026/09/17 18:32 [pubmed] PHST- 2026/09/17 15:38 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - E43 [pii] AID - 25_0436 [pii] AID - 10.5888/pcd23.250436 [doi] PST - epublish SO - Prev Chronic Dis. 2026 Sep 17;23:E43. doi: 10.5888/pcd23.250436. PMID- 42752205 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261024 IS - 2165-0497 (Electronic) IS - 2165-0497 (Linking) VI - 14 IP - 10 DP - 2026 Oct 6 TI - Multi-omics insights into growth impairment mechanisms in children with persistent diarrhea. PG - e0390525 LID - 10.1128/spectrum.03905-25 [doi] LID - e03905-25 AB - This study aimed to elucidate the key mechanisms underlying short stature with pediatric persistent diarrhea in children (PDC) and to propose an integrated model linking the butyrate-producing gut microbial niche, short-chain fatty acids (SCFAs), Th17/Treg balance, the growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis, and growth regulation. Samples from healthy controls (HCs), PDC patients without short stature (PDC-NS), and PDC patients with short stature (PDC-S) were analyzed using multi-omics profiling and machine learning-based predictive modeling. The results showed that PDC-S patients exhibited disruption of core butyrate-producing bacterial communities and related metabolic pathways, markedly reduced fecal butyrate levels, systemic Th17/Treg imbalance characterized by a pro-inflammatory state, and dual suppression of receptor- and ligand-level components of the GH-IGF-1 axis. Multi-omics machine learning identified a five-factor risk prediction panel composed of metabolic, immune, and endocrine markers, while causal inference further established butyrate as a central regulator of growth. Mouse experiments further validated that combined intervention with butyrate, Faecalibacterium prausnitzii, and recombinant human growth hormone (rhGH) ameliorated growth retardation. Overall, this study proposes a precision therapeutic strategy based on butyrate and GH co-intervention, providing new mechanistic insights and translational tools for PDC-associated short stature. IMPORTANCE: The research conducted in this study holds significant implications for improving the understanding and treatment of stunted growth with persistent diarrhea in children (PDC). By unraveling the intricate pathways linking gut microbiota, immune responses, and growth hormone regulation, the study sheds light on the underlying mechanisms contributing to stunting in these vulnerable populations. The identification of key factors, such as butyrate-producing bacteria and the Th17/Treg balance, not only enhances our comprehension of PDC-related growth impairment but also offers a promising avenue for targeted interventions. The proposed integrated mechanistic model and intervention strategy pave the way for precision therapies tailored to address the specific biological mechanisms at play, potentially leading to more effective and personalized treatments for children suffering from PDC-associated stunting. FAU - Shen, Jian AU - Shen J AUID- ORCID: 0000-0001-9332-5389 AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Yan, Junle AU - Yan J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Yuan, Ying AU - Yuan Y AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Le, Lilin AU - Le L AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Xu, Juan AU - Xu J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Bailu AU - Chen B AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Liu, Xiaoying AU - Liu X AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Huijie AU - Chen H AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Lijun AU - Chen L AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Yi, Meixiang AU - Yi M AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Lyu, Jiajia AU - Lyu J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Diao, Jun AU - Diao J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Zhang, Xinlin AU - Zhang X AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Zhao, Yinqiu AU - Zhao Y AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Jingru AU - Chen J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 LA - eng GR - E4-H200210199/Shanghai University of Traditional Chinese Medicine General Program/ GR - ZY(2021-2023)-0206-03/Shanghai Municipal Health Commission Three-Year Action Plan for TCM Development/ PT - Journal Article DEP - 20260917 PL - United States TA - Microbiol Spectr JT - Microbiology spectrum JID - 101634614 RN - 0 (Fatty Acids, Volatile) RN - 0 (Butyrates) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 12629-01-5 (Human Growth Hormone) RN - 9002-72-6 (Growth Hormone) SB - IM MH - Humans MH - *Diarrhea/microbiology/complications/metabolism MH - Animals MH - Multiomics MH - Child MH - Fatty Acids, Volatile/metabolism MH - Butyrates/metabolism MH - *Growth Disorders/microbiology/metabolism MH - Insulin-Like Growth Factor I/metabolism MH - Male MH - Mice MH - Female MH - Feces/microbiology/chemistry MH - Gastrointestinal Microbiome MH - Child, Preschool MH - T-Lymphocytes, Regulatory/immunology MH - Human Growth Hormone/metabolism MH - Th17 Cells/immunology MH - Faecalibacterium prausnitzii/physiology MH - Machine Learning MH - Growth Hormone MH - Bacteria/classification/genetics/isolation & purification/metabolism PMC - PMC13689471 OTO - NOTNLM OT - T helper 17 cells/regulatory T-cell balance OT - butyrate OT - growth hormone-insulin-like growth factor 1 axis OT - machine learning OT - multi-omics OT - persistent diarrhea in children OT - short-chain fatty acids OT - stunting COIS- The authors declare no conflict of interest. EDAT- 2026/09/17 18:33 MHDA- 2026/10/07 05:31 PMCR- 2026/09/17 CRDT- 2026/09/17 15:30 PHST- 2026/10/07 05:31 [medline] PHST- 2026/09/17 18:33 [pubmed] PHST- 2026/09/17 15:30 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - spectrum03905-25 [pii] AID - spectrum.03905-25 [pii] AID - 10.1128/spectrum.03905-25 [doi] PST - ppublish SO - Microbiol Spectr. 2026 Oct 6;14(10):e0390525. doi: 10.1128/spectrum.03905-25. Epub 2026 Sep 17. PMID- 42751864 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260923 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 58 IP - 1 DP - 2026 Dec TI - Association of body mass index with postoperative pulmonary complications and potential explanatory pathways in paediatric scoliosis correction surgery: a multicentre cohort study. PG - 2731716 LID - 10.1080/07853890.2026.2731716 [doi] LID - 2731716 AB - BACKGROUND: Postoperative pulmonary complications (PPCs) contribute substantially to morbidity after paediatric scoliosis correction surgery, but the relationship between preoperative body mass index (BMI) and PPCs remains uncertain. We evaluated this association and explored potential explanatory pathways and the incremental predictive value of BMI. METHODS: This retrospective cohort study included 1,165 patients from three Chinese tertiary hospitals. Associations between BMI and the composite PPC outcome were evaluated using multivariable regression. An orthogonalized causal forest estimated the average partial effect of continuous BMI on PPC probability, and variation in model-derived partial-effect predictions across sex and preoperative Cobb-angle strata was examined descriptively. Exploratory pathway analyses considered the Prognostic Nutritional Index (PNI), intraoperative blood loss, and fusion levels. At the completion of surgery, the incremental predictive value of BMI was assessed using an elastic-net model developed in centres 1 and 3 and externally validated in centre 2. RESULTS: PPCs occurred in 321 patients (27.55%). In the primary preoperative-adjusted model, each 1-kg/m(2) higher BMI was associated with lower odds of PPCs (aOR, 0.87; 95% CI, 0.83-0.91; p < 0.001). A secondary exploratory perioperative-adjusted model yielded a similar estimate (aOR, 0.85; 95% CI, 0.81-0.89; p < 0.001). Compared with normal weight, thinness was associated with higher odds of PPCs (aOR, 4.26; 95% CI, 2.74-6.67; p < 0.001), whereas overweight was associated with lower odds (aOR, 0.57; 95% CI, 0.34-0.91; p = 0.022). The causal forest yielded an inverse average partial-effect estimate for BMI (-0.031; 95% CI, -0.037 to -0.025; p < 0.001). Exploratory pathway analyses suggested small indirect components through PNI, blood loss, and fusion levels. Adding BMI increased the external-validation AUC from 0.658 to 0.703 (p < 0.001), representing a modest improvement in discrimination. CONCLUSIONS: Higher preoperative BMI was associated with lower odds of PPCs, with a concordant inverse causal-forest estimate under its identification assumptions. Low BMI or thinness may serve as a preoperative risk marker, while the examined pathways accounted for only small proportions of the association. At the end-of-surgery prediction time point, adding BMI provided modest incremental predictive value, although the model's external performance was modest and further prospective validation is required. FAU - Shi, Weihai AU - Shi W AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. FAU - Zhu, Shouqiang AU - Zhu S AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. FAU - Wang, Yan AU - Wang Y AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Drum Tower Clinical Medical School, Nanjing Medical University, Nanjing, China. FAU - Sun, Yanhua AU - Sun Y AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. FAU - Zheng, Zhiying AU - Zheng Z AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. FAU - Liu, Peiyu AU - Liu P AD - Department of Operating Room, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. FAU - Zhang, Ruocui AU - Zhang R AD - Post-Anesthesia Care Unit, Department of Anesthesiology and Surgery, Nanjing Drum Tower Hospital, Nanjing, China. FAU - Xia, Tianjiao AU - Xia T AD - Medical School of Nanjing University, Nanjing, China. FAU - Ma, Lulu AU - Ma L AD - Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China. FAU - Li, Min AU - Li M AUID- ORCID: 0000-0003-4853-4258 AD - Department of Anesthesiology, Peking University Third Hospital, Beijing, China. FAU - Bo, Jinhua AU - Bo J AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. FAU - Gu, Xiaoping AU - Gu X AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260917 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 SB - IM MH - Humans MH - *Scoliosis/surgery MH - Female MH - *Body Mass Index MH - Retrospective Studies MH - *Postoperative Complications/epidemiology/etiology MH - Male MH - Child MH - *Lung Diseases/etiology/epidemiology MH - Adolescent MH - China/epidemiology MH - Spinal Fusion/adverse effects MH - Risk Factors MH - Blood Loss, Surgical/statistics & numerical data PMC - PMC13587573 OTO - NOTNLM OT - Body mass index OT - paediatric scoliosis OT - postoperative pulmonary complications OT - scoliosis surgery COIS- No potential conflict of interest was reported by the authors. EDAT- 2026/09/17 15:37 MHDA- 2026/09/17 15:38 PMCR- 2026/09/17 CRDT- 2026/09/17 07:27 PHST- 2026/09/17 15:38 [medline] PHST- 2026/09/17 15:37 [pubmed] PHST- 2026/09/17 07:27 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 2731716 [pii] AID - 10.1080/07853890.2026.2731716 [doi] PST - ppublish SO - Ann Med. 2026 Dec;58(1):2731716. doi: 10.1080/07853890.2026.2731716. Epub 2026 Sep 17. PMID- 42751560 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260917 LR - 20260918 IS - 2296-875X (Print) IS - 2296-875X (Electronic) IS - 2296-875X (Linking) VI - 13 DP - 2026 TI - Developing expertise in laparoscopic management of total colonic aganglionosis cases: Duhamel vs. Swenson procedures. PG - 1882822 LID - 10.3389/fsurg.2026.1882822 [doi] LID - 1882822 AB - AIM: To describe technical evolution of minimally invasive surgery (MIS) for total colonic aganglionosis (TCA) either Duhamel or Swenson procedures conducted by a single pediatric surgical team. METHODS: 18 children with histologically proven TCA were managed between March 2018 and March 2022. All underwent laparoscopic definitive pull-through: Group A (n = 8) received laparoscopic-assisted transanal Swenson-type ileoanal pull-through, and Group B (n = 10) underwent laparoscopic Duhamel procedure. Thirteen patients presented with a pre-existing ileostomy; five were primary cases. Pre-operative evaluation included contrast enema and full-thickness rectal biopsy in every patient. RESULTS: Median age at definitive surgery was 3 years (range 18 months-5 years; mean +/- SD = 3.0 +/- 0.9 years). Median operative time was 4 h (range 3.5-5.5 h) for Group A and 5 h (range 4.5-6 h) for Group B. Median follow-up was 5 years (range 3-6 years). Early complications included two anastomotic stenoses (Group A) successfully treated with dilatation. No anastomotic leaks occurred. Median daily stool frequency at 6 months was 7 (range 5-10) in Group A vs. 5 (range 4-7) in Group B, improving to 3 (range 2-4) and 2 (range 1-3), respectively, by last follow-up. Fecal incontinence occurred in two patients (Group A). Three patients required loperamide and six cases used dietary fiber modification. CONCLUSION: Laparoscopic management of TCA is safe and feasible. Both Swenson-type and Duhamel approaches yield acceptable continence and growth outcomes, with the choice tailored to rectal anatomy and continence risk. CI - (c) 2026 Arafa, Abouelfadl, Eldomiaty, Ahmed, Azzam, Qinawy, Anwar and Ragab. FAU - Arafa, Ahmed AU - Arafa A AD - Pediatric Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Abouelfadl, Mohamed Hamed AU - Abouelfadl MH AD - Pediatric Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Eldomiaty, Belal AU - Eldomiaty B AD - Pediatric Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Ahmed, Aboubakr AU - Ahmed A AD - Pediatric Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Azzam, Ahmed AU - Azzam A AD - Pediatric Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Qinawy, Mohamad AU - Qinawy M AD - Pediatric Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Anwar, Seham AU - Anwar S AD - Pediatric Surgery Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt. FAU - Ragab, Ahmed S AU - Ragab AS AD - Pediatric Surgery Department, Faculty of Medicine, Portsaid University, Port Said, Egypt. LA - eng PT - Journal Article DEP - 20260902 PL - Switzerland TA - Front Surg JT - Frontiers in surgery JID - 101645127 PMC - PMC13580329 OTO - NOTNLM OT - Duhamel OT - Swenson OT - minimal invasive surgery OT - surgical expertise OT - total colonic aganglionosis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/17 15:39 MHDA- 2026/09/17 15:40 PMCR- 2026/09/02 CRDT- 2026/09/17 07:09 PHST- 2026/05/16 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/09/17 15:40 [medline] PHST- 2026/09/17 15:39 [pubmed] PHST- 2026/09/17 07:09 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 10.3389/fsurg.2026.1882822 [doi] PST - epublish SO - Front Surg. 2026 Sep 2;13:1882822. doi: 10.3389/fsurg.2026.1882822. eCollection 2026. PMID- 42751489 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260917 LR - 20260918 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Explainable machine learning for age-specific talent identification in Chinese youth football. PG - 1912796 LID - 10.3389/fspor.2026.1912796 [doi] LID - 1912796 AB - BACKGROUND AND AIMS: To identify elite youth football players in China, we developed an interpretable machine learning model. METHODS: We modeled each age group separately to track changes in predictive factors across different age groups. A cross-sectional analysis included 398 players from the 2024 Yunnan Football Association Elite Training Camp (U8 to U12). All participants underwent a multidimensional assessment covering anthropometric, physical, technical, psychological, and match performance dimensions. In our prediction model, coaches' selection of provincial elite players was used as the outcome variable. Three classifiers: XGBoost, Random Forest, and Logistic Regression, were trained with hyperparameter tuning and 5-fold cross-validation. Then we used SHapley Additive exPlanations (SHAP) to interpret our models. RESULTS: The best-performing model demonstrated high discriminative ability (test set ROC-AUC: 0.900-0.957). SHAP analysis indicated that dribbling speed and standing long jump consistently mattered at all ages, while sprint performance were especially important for the U8 and U10 groups. Notably, for U12 males, left-foot shooting skill was the strongest predictor, while for U12 females, tactical awareness during matches emerged as most important. Psychological traits contributed little predictive value. When we applied retrospectively to national selection data, the U12M model showed fair agreement (K = 0.269) but identified 40%-47% of national elites and highlighted several overlooked high-potential players. CI - (c) 2026 Tong, Bi, Li, Chen, Liu and Chen. FAU - Tong, Yan AU - Tong Y AD - School of Physical Education, Yunnan University, Kunming, China. FAU - Bi, Jingyi AU - Bi J AD - School of Life Sciences, Yunnan University, Kunming, China. FAU - Li, Shixin AU - Li S AD - Kunming Institute of Zoology, University of Chinese Academy of Sciences, Beijing, China. FAU - Chen, Luohang AU - Chen L AD - School of Physical Education, Yunnan University, Kunming, China. FAU - Liu, Chun AU - Liu C AD - School of Physical Education, Yunnan University, Kunming, China. FAU - Chen, Hengxin AU - Chen H AD - School of Physical Education, Yunnan University, Kunming, China. LA - eng PT - Journal Article DEP - 20260902 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13579789 OTO - NOTNLM OT - Chinese athletes OT - explainable machine learning OT - predictive modeling OT - talent identification OT - youth football COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/17 15:39 MHDA- 2026/09/17 15:40 PMCR- 2026/09/02 CRDT- 2026/09/17 06:59 PHST- 2026/06/18 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/17 15:40 [medline] PHST- 2026/09/17 15:39 [pubmed] PHST- 2026/09/17 06:59 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 10.3389/fspor.2026.1912796 [doi] PST - epublish SO - Front Sports Act Living. 2026 Sep 2;8:1912796. doi: 10.3389/fspor.2026.1912796. eCollection 2026. PMID- 42751182 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260918 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Childhood asthma and the microbiome: from gut-lung axis mechanisms to precision prevention strategies. PG - 1902053 LID - 10.3389/fimmu.2026.1902053 [doi] LID - 1902053 AB - Childhood asthma is a highly heterogeneous chronic respiratory disease, and its onset and progression are intricately linked to genetic susceptibility, environmental exposure, immune development, and the establishment of the early-life microbiome. In recent years, studies on the gut and respiratory microbiomes have suggested that the composition, metabolic functions, and interactions of microbial communities with the host immune system may be involved in the formation of asthma susceptibility, shaping of inflammatory phenotypes, and disease progression in children. The gut-lung axis, as an important pathway connecting gut microbiome, respiratory immunity, and systemic inflammatory responses, provides a new perspective for understanding the early mechanisms of childhood asthma. This article reviews the characteristics of the respiratory and gut microbiomes associated with childhood asthma, with a focus on the roles of the gut-lung axis, microbial metabolites, mucosal immune regulation, and environmental exposure. It also evaluates the research progress of probiotics, prebiotics, nutritional interventions, and novel microecological therapies. Additionally, the potential of microbial maturity, microbial metabolites, and immunophenotypes as biomarkers for risk prediction, phenotype stratification, and treatment response is analyzed. Furthermore, the role of multi-omics integration in supporting the identification of responsive populations, matching of intervention strategies, and dynamic monitoring of efficacy is discussed. Current evidence suggests that the microbiome offers promising targets for risk assessment and precision prevention of childhood asthma. However, relevant research still faces challenges such as ambiguous causality, high cohort heterogeneity, limited reproducibility of candidate biomarkers, inconsistent intervention outcomes, and insufficient evidence of long-term safety. At present, most biomarkers and multi-omics models remain in the stage of association discovery, lacking unified thresholds, cross-cohort validation, and biomarker-guided randomized controlled trials in children. Therefore, they cannot be routinely used for patient stratification or intervention selection. Future efforts should rely on standardized longitudinal birth cohorts, multi-omics integration, external validation, and high-quality clinical trials to clarify the incremental value of microbiome biomarkers over traditional clinical indicators and their clinical utility in the individualized management of childhood asthma. CI - Copyright (c) 2026 Liang, Chen, Hu, Guo, Yang, Guo and Zhang. FAU - Liang, Xuan AU - Liang X AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Chen, De AU - Chen D AD - Emergency Medical Center, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Hu, Jiafen AU - Hu J AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Guo, Li AU - Guo L AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Yang, Hui AU - Yang H AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Guo, Qi AU - Guo Q AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Zhang, Rongfang AU - Zhang R AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. LA - eng PT - Journal Article PT - Review DEP - 20260902 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Asthma/prevention & control/microbiology/immunology/etiology MH - *Gastrointestinal Microbiome/immunology MH - Child MH - *Lung/immunology/microbiology MH - Animals MH - Precision Medicine MH - *Microbiota MH - Biomarkers MH - Probiotics/therapeutic use MH - Environmental Exposure/adverse effects MH - Disease Susceptibility PMC - PMC13580037 OTO - NOTNLM OT - childhood asthma OT - gut microbiome OT - gut-lung axis OT - microbiome OT - precision prevention OT - respiratory microbiome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/17 15:39 MHDA- 2026/09/17 15:40 PMCR- 2026/09/02 CRDT- 2026/09/17 06:13 PHST- 2026/06/06 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/17 15:40 [medline] PHST- 2026/09/17 15:39 [pubmed] PHST- 2026/09/17 06:13 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1902053 [doi] PST - epublish SO - Front Immunol. 2026 Sep 2;17:1902053. doi: 10.3389/fimmu.2026.1902053. eCollection 2026. PMID- 42751027 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260917 LR - 20260919 IS - 2220-3230 (Print) IS - 2220-3230 (Electronic) IS - 2220-3230 (Linking) VI - 16 IP - 3 DP - 2026 Sep 18 TI - Growth and development following paediatric kidney transplantation: Mechanisms, influencing factors, and clinical management. PG - 120986 LID - 10.5500/wjt.120986 [doi] LID - 120986 AB - Paediatric kidney transplantation substantially improves survival and quality of life in children with end-stage kidney disease. However, impaired linear growth and broader developmental challenges remain common after transplantation. This article provides an evidence-based narrative review of the mechanisms, clinical determinants, monitoring strategies, and management options for post-transplant growth and development in paediatric kidney recipients, with particular emphasis on the growth hormone (GH)-insulin-like growth factor 1 axis, graft function, immunosuppression, nutrition, GH therapy, and long-term follow-up. Current evidence indicates that post-transplant growth is influenced by age at transplantation, pretransplant growth status, graft function, cumulative corticosteroid exposure, nutritional and metabolic status, and the selective use of recombinant human GH. Younger age at transplantation and steroid-sparing strategies are consistently associated with better height outcomes, whereas chronic graft dysfunction, persistent inflammation, and metabolic complications may attenuate catch-up growth. Emerging biomarkers and precision-medicine tools are promising, but most remain insufficiently validated for routine growth-focused decision-making. Optimising growth after paediatric kidney transplantation requires early transplantation when feasible, preservation of graft function, careful balancing of rejection prevention against growth toxicity, multidisciplinary nutritional and endocrine support, and structured long-term follow-up. The evidence base is expanding, but high-quality multicentre longitudinal studies are still needed. CI - (c)Author(s) 2026. FAU - Wang, Yu-Yang AU - Wang YY AD - Tongliao Clinical Medical College, Inner Mongolia Medical University, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Hang, Gai AU - Hang G AD - Department of Urinary Surgery, Tongliao City Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Wen, Quan AU - Wen Q AD - Department of Urinary Surgery, Tongliao City Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Guo, Yun-Peng AU - Guo YP AD - Tongliao Clinical Medical College, Inner Mongolia Medical University, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Long, Chen AU - Long C AD - Department of Surgery, Inner Mongolia Medical University, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Chen, Bo AU - Chen B AD - Department of Urinary Surgery, Tongliao People's Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China. chenmuxin@126.com. LA - eng PT - Journal Article PT - Review PL - United States TA - World J Transplant JT - World journal of transplantation JID - 101608356 PMC - PMC13579424 OTO - NOTNLM OT - Graft function OT - Growth and development OT - Growth hormone OT - Immunosuppression OT - Narrative review OT - Paediatric kidney transplantation COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. EDAT- 2026/09/17 15:39 MHDA- 2026/09/17 15:40 PMCR- 2026/09/18 CRDT- 2026/09/17 05:40 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/17 15:40 [medline] PHST- 2026/09/17 15:39 [pubmed] PHST- 2026/09/17 05:40 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.5500/wjt.120986 [doi] PST - ppublish SO - World J Transplant. 2026 Sep 18;16(3):120986. doi: 10.5500/wjt.120986. PMID- 42750879 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260917 LR - 20260918 IS - 2666-5352 (Electronic) IS - 2666-5352 (Linking) VI - 12 DP - 2026 Dec TI - Effectiveness of the digital parental-family-centered program for problematic gaming and screen use in a clinical child and adolescent population. PG - 100848 LID - 10.1016/j.puhip.2026.100848 [doi] LID - 100848 AB - OBJECTIVES: Problematic gaming and screen use may be associated with psychosocial, academic, and mental-health difficulties in children. The digital Parental-Family-Centered Program (P-FAME) is a brief, digitally delivered, parent-focused program developed in Child and Adolescent Mental Health Services. This study examined its feasibility and preliminary associations with change in child screen time, family functioning, and parental stress over time. STUDY DESIGN: Prospective single-group pre-post feasibility study. METHODS: Twenty-nine parents of 22 children (mean child age 10.6 years) participated in three online group sessions delivered over five weeks. Standardized measures were administered at baseline and post-intervention, including Screens-Q (screen time and rules), SCORE-15 (family functioning), and the Parental Stress Scale (PSS). Linear mixed-effects models accounting for clustering within families estimated change from pre-intervention to post-intervention. RESULTS: From baseline to post-intervention, children's weekly screen time decreased (adjusted mean difference: -1400 min/week, p < .001; d = -1.81), as did parental stress (p = .036; d = -0.63). The PSS stress subscale also decreased (p = .048, d = 0.59). No statistically significant changes were observed in overall family functioning or parental satisfaction. Child ADHD diagnosis and age did not significantly moderate the observed changes. CONCLUSIONS: In this uncontrolled clinical study, participation in P-FAME was associated with lower child screen time and parental stress. The findings provide preliminary feasibility and outcome signals that require confirmation in adequately powered controlled studies with longer follow-up and broader implementation measures. CI - (c) 2026 The Authors. FAU - Claesdotter-Knutsson, Emma AU - Claesdotter-Knutsson E AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Regional Outpatient Care, Skane University Hospital, Lund, Region Skane, Sweden. FAU - Wilts, Sophie AU - Wilts S AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Regional Outpatient Care, Skane University Hospital, Lund, Region Skane, Sweden. AD - Faculty of Medicine, University of Amsterdam, Amsterdam, the Netherlands. FAU - Werner, Marie AU - Werner M AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Regional Outpatient Care, Skane University Hospital, Lund, Region Skane, Sweden. FAU - Andre, Frida AU - Andre F AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Primary Health Care, Region Dalarna, Sweden. FAU - Andersson, Mitchell J AU - Andersson MJ AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Regional Outpatient Care, Skane University Hospital, Lund, Region Skane, Sweden. LA - eng PT - Journal Article DEP - 20260824 PL - England TA - Public Health Pract (Oxf) JT - Public health in practice (Oxford, England) JID - 101774776 PMC - PMC13579036 OTO - NOTNLM OT - Digital intervention OT - Family intervention OT - Problematic gaming OT - Problematic screen use COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/17 15:36 MHDA- 2026/09/17 15:37 PMCR- 2026/08/24 CRDT- 2026/09/17 05:13 PHST- 2026/04/16 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/17 15:37 [medline] PHST- 2026/09/17 15:36 [pubmed] PHST- 2026/09/17 05:13 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - S2666-5352(26)00127-8 [pii] AID - 100848 [pii] AID - 10.1016/j.puhip.2026.100848 [doi] PST - epublish SO - Public Health Pract (Oxf). 2026 Aug 24;12:100848. doi: 10.1016/j.puhip.2026.100848. eCollection 2026 Dec. PMID- 42750677 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261002 LR - 20261002 IS - 2633-4402 (Electronic) IS - 2633-4402 (Linking) VI - 6 DP - 2026 TI - How to improve uptake and adherence to dietary trials in gestational diabetes amongst South Asian women: insights from patient and public involvement and engagement. PG - 77 LID - 10.3310/nihropenres.14303.3 [doi] LID - 77 AB - BACKGROUND: Gestational diabetes mellitus (GDM) is associated with adverse maternal and neonatal outcomes and affects approximately 10-20% of pregnancies in the UK. The prevalence of GDM among South Asian women is around twice that of White British women, and they are also twice as likely to develop type 2 diabetes following diagnosis. Although multiple dietary interventions have been explored to improve glycaemic control in GDM, no single dietary approach has proven consistently effective in improving health outcomes. METHODS: We conducted a patient and public involvement and engagement (PPIE) activity with South Asian women to inform a trial evaluating the acceptability, feasibility, and safety of an intermittent low-energy diet (ILED) in GDM. PPIE input was particularly valuable in addressing lower-than-anticipated recruitment and retention, especially among South Asian women, and provided insights into sociocultural barriers and facilitators to improve trial design and participation. CONCLUSIONS: Three priorities emerged as a potential means of enhancing engagement with South Asian women: addressing vulnerability (including trust and loss of control), improving accessibility, and reducing mental load (including competing priorities, emotional wellbeing, and family influence). These insights informed the trial design and recruitment strategies, building on existing literature which highlights the urgent need to address systemic racial biases and inequalities in healthcare and research. CI - Copyright: (c) 2026 Dapre E et al. FAU - Dapre, Elizabeth AU - Dapre E AUID- ORCID: 0000-0001-8220-4514 AD - Centre for Primary Care and Health Services Research, The University of Manchester Centre for Primary Care, Manchester, England, M13 9PL, UK. FAU - Harvie, Michelle AU - Harvie M AUID- ORCID: 0000-0001-9761-3089 AD - Department of Nutrition and Dietetics, Manchester University NHS Foundation Trust, Manchester, England, M13 9LW, UK. AD - Division of Cancer Sciences, The University of Manchester Division of Cancer Sciences, Manchester, England, M13 9NT, UK. FAU - Issa, Basil AU - Issa B AD - Diabetes, Endocrinology and Metabolic Services, Manchester University NHS Foundation Trust, Manchester, England, M13 9WL, UK. FAU - McMillan, Brian AU - McMillan B AUID- ORCID: 0000-0002-7635-8354 AD - Centre for Primary Care and Health Services Research, The University of Manchester Centre for Primary Care, Manchester, England, M13 9PL, UK. FAU - Morley, Helen AU - Morley H AUID- ORCID: 0000-0002-7635-8354 AD - Division of Psychology and Mental Health, The University of Manchester Division of Psychology and Mental Health, Manchester, England, M13 9PL, UK. LA - eng PT - Journal Article DEP - 20260929 PL - England TA - NIHR Open Res JT - NIHR open research JID - 9918333281906676 PMC - PMC13575402 OAB - South Asian women are twice as likely to develop gestational diabetes compared to White British women but remain underrepresented in clinical trials. Recruitment challenges in a recent intermittent diet trial prompted discussions with South Asian women to improve the inclusivity of the research design. Seventeen women ('contributors') from Greater Manchester, with personal or family experience of gestational diabetes, reviewed study materials and provided feedback on improving participation and trial design. Key barriers identified included lack of trust in researchers and perceived "research fatigue," where participants felt repeatedly asked to take part in research without seeing meaningful improvements in healthcare. Dietary adherence during pregnancy was also considered challenging due to cravings, household responsibilities, and caregiving roles. Contributors recommended family-based meal planning, pictorial guides for healthier alternatives, and financial support for childcare to facilitate attendance at trial appointments. Flexible face-to-face and online appointment options were positively received. Emotional wellbeing was also highlighted as a key factor influencing adherence, with suggestions for support groups to help participants manage stress and avoid using food for comfort. These discussions informed recommendations for more inclusive research design, which are shared to support future studies. OABL- eng OTO - NOTNLM OT - South Asian women OT - diet OT - gestational diabetes OT - patient and public involvement and engagement (PPIE) OT - trial design COIS- Competing interests: Michelle Harvie has coauthored three self-help books for the public to follow intermittent diets. All author proceeds are paid directly to the charity Prevent Breast Cancer (registered charity number 1109839) to fund breast cancer research. The other authors declare no conflicts of interest. EDAT- 2026/09/17 05:35 MHDA- 2026/09/17 05:36 PMCR- 2026/09/29 CRDT- 2026/09/17 04:39 PHST- 2026/09/24 00:00 [accepted] PHST- 2026/09/17 05:35 [pubmed] PHST- 2026/09/17 05:36 [medline] PHST- 2026/09/17 04:39 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3310/nihropenres.14303.3 [doi] PST - epublish SO - NIHR Open Res. 2026 Sep 29;6:77. doi: 10.3310/nihropenres.14303.3. eCollection 2026. PMID- 42750024 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260919 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Aug 26 TI - Pancreatic steatosis is associated with exocrine pancreatic dysfunction in children with MASLD: a prospective cross-sectional study. LID - 10.1186/s12887-026-07464-4 [doi] LID - 879 AB - OBJECTIVE: This study aimed to evaluate the relationship between pancreatic steatosis and fecal elastase (FE) levels in children with hepatic steatosis, compare clinical, metabolic, and imaging findings according to metabolic dysfunction-associated steatotic liver disease (MASLD) status, and determine whether this relationship persists within children with MASLD. METHODS: This prospective cross-sectional study was conducted in the Pediatric Gastroenterology and Pediatric Endocrinology Departments of Kayseri City Hospital. Participants were classified according to the presence of MASLD. Clinical characteristics, anthropometric measurements, metabolic parameters, ultrasonographic findings, and FE levels were compared between groups. FE levels were categorized as normal (> 200 microg/g), low (100-200 microg/g), and severely low (< 100 microg/g). For binary analyses, low FE was defined as /=95th percentile (OR: 3.31, 95% CI: 1.24-8.87, p = 0.017) were independently associated with low FE levels. Within the MASLD group, pancreatic steatosis grade was significantly associated with low FE levels. Pancreatic steatosis grade showed the highest discriminatory performance for low FE levels among the evaluated parameters (AUC = 0.76). CONCLUSIONS: Pancreatic steatosis was more frequent in children with MASLD, and its severity was associated with low FE levels both in the overall cohort and within the MASLD group. Imaging-based pancreatic findings showed moderate discriminatory performance for low FE levels but should not be interpreted as validated diagnostic thresholds. Pancreatic steatosis may represent a clinically relevant feature of pediatric MASLD in relation to possible subclinical alterations in exocrine pancreatic function. CI - (c) 2026. The Author(s). FAU - Daldaban Sarica, Buket AU - Daldaban Sarica B AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. buketdaldaban@gmail.com. FAU - Gumus, Ummugulsum Ozgul AU - Gumus UO AD - Department of Radiology, Division of Pediatric Radiology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. FAU - Kara, Leyla AU - Kara L AD - Department of Pediatrics, Division of Endocrinology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. FAU - Gok, Ebru AU - Gok E AD - Department of Pediatrics, Division of Endocrinology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. FAU - Koca, Serkan Bilge AU - Koca SB AD - Department of Pediatrics, Division of Endocrinology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. FAU - Kirkgoz, Tarik AU - Kirkgoz T AD - Department of Pediatrics, Division of Endocrinology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. LA - eng PT - Journal Article DEP - 20260826 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - EC 3.4.21.36 (Pancreatic Elastase) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Prospective Studies MH - Male MH - Female MH - Child MH - *Pancreatic Elastase/analysis/metabolism MH - *Pancreatic Diseases/complications/etiology MH - Feces/enzymology/chemistry MH - *Exocrine Pancreatic Insufficiency/etiology MH - *Pancreas, Exocrine/physiopathology MH - Adolescent MH - Ultrasonography PMC - PMC13584307 OTO - NOTNLM OT - Fecal elastase OT - Metabolic dysfunction-associated steatotic liver disease OT - Pancreatic exocrine function OT - Pancreatic fat infiltration COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was granted by the Clinical Research Ethics Committee of Kayseri City Hospital on January 14, 2026, with approval decision number 752. The study was conducted in accordance with the principles of the Declaration of Helsinki (1964), as revised in 2013. Written informed consent to participate was obtained from the participants' parents or legal guardians; specifically, parental or legal guardian consent was obtained for every participant younger than 16 years. Consent for publication: Not appilicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/17 05:35 MHDA- 2026/09/17 05:36 PMCR- 2026/08/26 CRDT- 2026/09/16 23:55 PHST- 2026/05/21 00:00 [received] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/09/17 05:36 [medline] PHST- 2026/09/17 05:35 [pubmed] PHST- 2026/09/16 23:55 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - 10.1186/s12887-026-07464-4 [pii] AID - 7464 [pii] AID - 10.1186/s12887-026-07464-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Aug 26;26(1):879. doi: 10.1186/s12887-026-07464-4. PMID- 42749631 OWN - NLM STAT- Publisher LR - 20260916 IS - 1348-4540 (Electronic) IS - 0918-8959 (Linking) DP - 2026 Sep 15 TI - Association between fasting plasma glucose at diagnosis and large-for-gestational-age in Japanese women with gestational diabetes mellitus: Hamamatsu GRACE Study 6. LID - 10.1507/endocrj.EJ26-0368 [doi] AB - Maternal high fasting plasma glucose (FPG) is a well-known risk factor for large-for-gestational-age (LGA) infants. However, this association remains unclear among Japanese women with gestational diabetes mellitus (GDM). Therefore, we examined this issue in Japanese women with GDM, accounting for body mass index (BMI). This retrospective study analyzed 543 Japanese women with GDM and evaluated the associations of 1-standard deviation (SD) increments in fasting, 1-hour, and 2-hour plasma glucose and HbA1c levels with LGA. LGA was defined as birth weight above the 90th percentile for gestational age. Multivariable logistic regression was used to estimate ORs and 95% CIs for LGA per 1-SD increment in fasting, 1-hour, and 2-hour plasma glucose and HbA1c. Model 1 was adjusted for maternal age, smoking, family history of diabetes, insulin use, parity, gestational age at delivery, gestational age at diagnosis, and gestational weight gain; Model 2 was additionally adjusted for pre-pregnancy BMI. The prevalence of LGA was 9.6%. In model 1, the FPG was independently and positively associated with LGA (adjusted OR 1.44, 95% CI: 1.07-1.94). The area under the receiver operating characteristic (ROC) curve for FPG in discriminating LGA was 0.692, with an optimal cutoff of 86.0 mg/dL. After additional adjustment for pre-pregnancy BMI (model 2), FPG was no longer associated with LGA. Other glycemic parameters were not associated with low birth weight, small-for-gestational-age, or LGA. FPG at GDM diagnosis may provide limited discriminatory information for LGA. However, its association with LGA was attenuated after adjustment for pre-pregnancy BMI. FAU - Tsuriya, Daisuke AU - Tsuriya D AUID- ORCID: 0009-0001-7891-5046 AD - Division of Endocrinology and Metabolism, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan. FAU - Takeshita, Kei AU - Takeshita K AUID- ORCID: 0009-0008-1123-5581 AD - Division of Endocrinology and Metabolism, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan. FAU - Toyama, Yukino AU - Toyama Y AUID- ORCID: 0009-0003-0214-0947 AD - Division of Endocrinology and Metabolism, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan. FAU - Hashimoto, Takuya AU - Hashimoto T AUID- ORCID: 0000-0002-6761-0343 AD - Division of Endocrinology and Metabolism, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan. FAU - Kanamoto, Ayumi AU - Kanamoto A AUID- ORCID: 0009-0001-9894-9120 AD - Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime 790-0294, Japan. FAU - Miyake, Teruki AU - Miyake T AUID- ORCID: 0000-0002-9905-5356 AD - Department of Lifestyle-Related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Ehime 790-0294, Japan. FAU - Furukawa, Shinya AU - Furukawa S AUID- ORCID: 0000-0002-0041-7688 AD - Health Services Center, Ehime University, Ehime 790-8577, Japan. LA - eng PT - Journal Article DEP - 20260915 PL - Japan TA - Endocr J JT - Endocrine journal JID - 9313485 SB - IM OTO - NOTNLM OT - Body mass index OT - Fetal outcomes OT - Gestational diabetes mellitus EDAT- 2026/09/16 23:34 MHDA- 2026/09/16 23:34 CRDT- 2026/09/16 22:13 PHST- 2026/09/16 23:34 [medline] PHST- 2026/09/16 23:34 [pubmed] PHST- 2026/09/16 22:13 [entrez] AID - 10.1507/endocrj.EJ26-0368 [doi] PST - aheadofprint SO - Endocr J. 2026 Sep 15. doi: 10.1507/endocrj.EJ26-0368. PMID- 42749612 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261007 IS - 1871-403X (Print) IS - 1871-403X (Linking) VI - 20 IP - 5 DP - 2026 Sep-Oct TI - Urinary metabolomic profiling reveals distinct metabolic characteristics in children with overweight and obesity. PG - 409-417 LID - S1871-403X(26)00087-6 [pii] LID - 10.1016/j.orcp.2026.09.003 [doi] AB - BACKGROUND: Childhood obesity is a critical global public health problem. Untargeted metabolomics can identify metabolic alterations associated with childhood obesity, but pediatric evidence remains limited. This study characterized urinary metabolic profiles associated with overweight and obesity in children. METHODS: A total of 120 first-grade primary school children were selected. The population comprised 40 children with normal weight, 40 children with overweight, and 40 children with obesity, with equal sex distribution in each group. Urinary metabolic profiles were analyzed using liquid chromatography-mass spectrometry-based untargeted metabolomics, followed by multivariate analysis, differential feature analysis, pathway enrichment analysis, and ROC analysis. RESULTS: Compared with children with normal weight, children with overweight showed 69 differential metabolic features (40 upregulated and 29 downregulated), whereas children with obesity showed 193 (161 upregulated and 32 downregulated). Three of 37 and 15 of 83 pathways, respectively, met the exploratory criteria of raw P < 0.05 and pathway impact > 0.01. After FDR correction, two and four pathways remained statistically significant, respectively. Phenylalanine metabolism (FDR=0.015 and 0.001, respectively) and phenylalanine, tyrosine and tryptophan biosynthesis (FDR=0.036 and 0.012, respectively) were significant in both comparisons with the normal-weight group. Thirteen metabolic features showed discriminatory potential between children with obesity and children with normal weight, with N-acetyl-D-glucosamine showing an AUC of 0.889 (95% CI: 0.821-0.958). CONCLUSION: This study characterized urinary metabolic alterations and enriched pathways associated with overweight and obesity in children compared with normal weight. Several candidate metabolic features showed exploratory discriminatory potential but require targeted confirmation and independent validation. CI - Copyright (c) 2026 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. FAU - Chen, Yingzi AU - Chen Y AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China. FAU - Wen, Xiaosa AU - Wen X AD - Minhang District Centre for Disease Control and Prevention, Shanghai, China. FAU - He, Guanhao AU - He G AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China. FAU - Yu, Dan AU - Yu D AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China. FAU - Xu, Su AU - Xu S AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China. FAU - Ruan, Zengliang AU - Ruan Z AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Electronic address: rzl@seu.edu.cn. LA - eng PT - Journal Article DEP - 20260917 PL - Netherlands TA - Obes Res Clin Pract JT - Obesity research & clinical practice JID - 101303911 RN - 0 (Biomarkers) RN - 47E5O17Y3R (Phenylalanine) RN - 8DUH1N11BX (Tryptophan) RN - 42HK56048U (Tyrosine) SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Metabolomics/methods MH - *Pediatric Obesity/urine/metabolism MH - *Overweight/urine MH - *Metabolome MH - Body Mass Index MH - Biomarkers/urine MH - Phenylalanine/urine MH - Tryptophan/urine MH - Chromatography, Liquid MH - Tyrosine/urine OTO - NOTNLM OT - Childhood obesity OT - Metabolic pathways OT - Overweight OT - Untargeted metabolomics OT - Urinary metabolomics COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper EDAT- 2026/09/16 23:34 MHDA- 2026/10/07 23:30 CRDT- 2026/09/16 22:05 PHST- 2026/01/20 00:00 [received] PHST- 2026/09/10 00:00 [revised] PHST- 2026/09/13 00:00 [accepted] PHST- 2026/10/07 23:30 [medline] PHST- 2026/09/16 23:34 [pubmed] PHST- 2026/09/16 22:05 [entrez] AID - S1871-403X(26)00087-6 [pii] AID - 10.1016/j.orcp.2026.09.003 [doi] PST - ppublish SO - Obes Res Clin Pract. 2026 Sep-Oct;20(5):409-417. doi: 10.1016/j.orcp.2026.09.003. Epub 2026 Sep 17. PMID- 42749360 OWN - NLM STAT- Publisher LR - 20260922 IS - 1468-3288 (Electronic) IS - 0017-5749 (Linking) DP - 2026 Sep 16 TI - Divergent microbial preludes to necrotising enterocolitis defined by gut phages and bacterial resistomes. LID - gutjnl-2026-338976 [pii] LID - 10.1136/gutjnl-2026-338976 [doi] AB - BACKGROUND: Translating microbiome correlations into robust predictive features for complex gut disorders remains elusive, partly due to oversimplified models of pathogenesis and neglect of the virome, a key player in microbial ecosystems. Necrotising enterocolitis (NEC), a devastating disease of preterm infants with no reliable clinical predictors, exemplifies this challenge. OBJECTIVE: To determine the predictive potential of the gut prophageome and polymicrobial aetiologies for NEC. DESIGN: We applied integrated metagenomic and metatranscriptomic analyses and machine learning to 1825 longitudinal stool samples from 43 preterm infants who later developed NEC and 86 gestational age-matched and birthweight-matched controls across three US hospitals. We characterised gut prophageome acquisitions and their association with clinical exposures, including antibiotics, diet and pharmacotherapies. To predict NEC risk, we integrated pre-onset prophageome, antibacterial resistome and bacteriome profiles with neonatal pathology, stratifying the cohort by disease onset timing (early: 40 days) for separate analysis. RESULTS: NEC cases exhibited distinct viral diversity trajectories before disease onset. Early-onset NEC was best predicted by phage-bacterial interaction signatures (75% accuracy, 81% sensitivity). Metatranscriptomics revealed increased phage DNA abundance with low gene expression, suggesting a lysogenic lifestyle that may stabilise pathobionts. These phages encode metabolic genes potentially enhancing pathobiont resilience. Late-onset NEC was best predicted by antibacterial resistome profiles (83% accuracy). CONCLUSION: The gut prophageome serves as both a source of pre-symptomatic predictive signals and an active modulator of NEC pathogenesis, with distinct microbial mechanisms driving early-onset and late-onset disease. These polymicrobial etiologies inform strategies for early detection, risk stratification and the development of microbiome-targeted preventive and therapeutic interventions. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Zhang, Kailun AU - Zhang K AUID- ORCID: 0000-0002-6994-9033 AD - The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA. AD - Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri, USA. FAU - Gorelik, Mark G AU - Gorelik MG AD - The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA. AD - Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri, USA. FAU - Sullivan, Janice E AU - Sullivan JE AD - Department of Pediatrics, University of Louisville School of Medicine, Norton Children's Hospital, Louisville, Kentucky, USA. FAU - Radmacher, Paula AU - Radmacher P AD - Department of Pediatrics, University of Louisville School of Medicine, Norton Children's Hospital, Louisville, Kentucky, USA. FAU - Escobedo, Marilyn AU - Escobedo M AD - Department of Pediatrics, University of Oklahoma, Oklahoma City, Oklahoma, USA. FAU - Warner, Barbara B AU - Warner BB AD - Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA dantas@wustl.edu warnerbb@wustl.edu tarr@wustl.edu. FAU - Tarr, Phillip I AU - Tarr PI AD - Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA dantas@wustl.edu warnerbb@wustl.edu tarr@wustl.edu. AD - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA. FAU - Dantas, Gautam AU - Dantas G AD - The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA dantas@wustl.edu warnerbb@wustl.edu tarr@wustl.edu. AD - Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, Missouri, USA. AD - Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA. AD - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA. AD - Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA. LA - eng GR - T32 DK077653/DK/NIDDK NIH HHS/United States GR - U01 AT012998/AT/NCCIH NIH HHS/United States GR - R01 AI155893/AI/NIAID NIH HHS/United States GR - UH3 AI083265/AI/NIAID NIH HHS/United States GR - R01 HD092414/HD/NICHD NIH HHS/United States GR - P30 DK052574/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260916 PL - England TA - Gut JT - Gut JID - 2985108R SB - IM OTO - NOTNLM OT - BIOMARKERS OT - GASTROINTESTINAL MICROBIOME OT - INFLAMMATORY MECHANISMS OT - NECROTIZING ENTEROCOLITIS COIS- Competing interests: G.D. is a consultant to and a member of the Scientific Advisory Board of Pluton Biosciences, which is developing methods for discovering environmental microbes for commercial applications. G.D. has consulted for SNIPR Technologies Ltd. in the last 5 years. P.I.T. is a holder of equity in, a consultant to, and a member of the Scientific Advisory Board of MediBeacon Inc., which is developing a technology to non-invasively measure intestinal permeability in humans. P.I.T. is a co-inventor on patents assigned to MediBeacon (U.S. patents 11,285,223 and 11,285,224 titled "Compositions and methods for assessing gut function" and U.S. patent application 2022-0326255, "Methods of monitoring mucosal healing"), which might earn royalties if the technology is commercialised. He is a member of the Data Safety Monitoring Board of Inmunova, which is developing an immune biologic targeting Shiga toxin-producing E. coli infections, for which he receives no compensation, except for reimbursement of expenses. P.I.T. receives royalties from UpToDate for two sections on intestinal E. coli infections. The authors declare no other competing interests. EDAT- 2026/09/16 23:34 MHDA- 2026/09/16 23:34 CRDT- 2026/09/16 20:53 PHST- 2026/03/31 00:00 [received] PHST- 2026/08/01 00:00 [accepted] PHST- 2026/09/16 23:34 [medline] PHST- 2026/09/16 23:34 [pubmed] PHST- 2026/09/16 20:53 [entrez] AID - gutjnl-2026-338976 [pii] AID - 10.1136/gutjnl-2026-338976 [doi] PST - aheadofprint SO - Gut. 2026 Sep 16:gutjnl-2026-338976. doi: 10.1136/gutjnl-2026-338976. PMID- 42748416 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 1745-5065 (Electronic) IS - 1745-5057 (Linking) VI - 22 DP - 2026 Jan-Dec TI - Genitourinary syndrome of lactation: An underrecognized postpartum condition affecting women's vulvovaginal, urinary and sexual health. PG - 17455057261490606 LID - 10.1177/17455057261490606 [doi] AB - Postpartum care is increasingly viewed as a continuum of maternal recovery rather than a single visit at six weeks. Within this broader view, however, the genitourinary and sexual health of breastfeeding women remains insufficiently addressed. Genitourinary syndrome of lactation (GSL) has recently been proposed to describe postpartum and lactation-related vulvovaginal, urinary and sexual symptoms that may be linked to the hypoestrogenic hormonal environment of breastfeeding. During lactation, suckling-related prolactin secretion suppresses hypothalamic-pituitary-ovarian activity and may maintain low estradiol levels, particularly during amenorrhea. Although the term deliberately echoes genitourinary syndrome of menopause, GSL belongs to a different clinical setting: a woman recovering from pregnancy and birth, adapting to breastfeeding, living with sleep deprivation and body changes, and gradually rebuilding sexual intimacy. This narrative perspective review summarizes the emerging evidence on GSL and offers a practical framework for recognition, differential diagnosis, screening and breastfeeding-supportive management. GSL should not be reduced to vaginal dryness, nor should every postpartum sexual or urinary symptom be attributed to lactation-related hormonal deprivation. Assessment should consider perineal scar pain, pelvic floor dysfunction, vestibulodynia, vulvovaginal infections, vulvar dermatoses, urinary tract disorders, hormonal contraception and psychosocial contributors; bowel symptoms may indicate broader pelvic floor or obstetric injury rather than GSL itself. Management is best approached in a stepped and individualized manner, beginning with education, validation, vulvar care, lubricants, vaginal moisturizers, pelvic floor physiotherapy and sexual counselling when indicated. For persistent moderate-to-severe mucosal symptoms, low-dose vaginal estrogen is a reasonable option after shared decision-making, particularly once lactation is established. Vaginal prasterone lacks lactation-specific safety and efficacy evidence and cannot currently be recommended routinely. Recognizing GSL is not an argument against breastfeeding; it is a way to make postpartum care more complete. FAU - Orozco Fernandez, Rodrigo AU - Orozco Fernandez R AUID- ORCID: 0000-0001-7521-0676 AD - Department of Obstetrics and Gynecology, Hospital Quironsalud Malaga, Malaga, Spain. RINGGOLD: 221954 AD - Department of Obstetrics and Gynecology, Clinica Palacios Malaga, Malaga, Spain. FAU - Gil-Antunano, Santiago Palacios AU - Gil-Antunano SP AD - Department of Obstetrics and Gynecology, Clinica Palacios Madrid, Madrid, Spain. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - United States TA - Womens Health (Lond) JT - Women's health (London, England) JID - 101271249 SB - IM MH - Humans MH - Female MH - *Lactation/physiology MH - *Breast Feeding/adverse effects MH - *Postpartum Period MH - *Sexual Health MH - Syndrome MH - *Female Urogenital Diseases/diagnosis MH - Pregnancy MH - Sexual Dysfunction, Physiological OAB - Many women experience vaginal dryness, burning, pain during sex, urinary discomfort or loss of sexual confidence after childbirth, especially while breastfeeding. These problems are often dismissed as a normal part of having a baby, even when they affect comfort, relationships and quality of life. This review discusses the recently proposed term "genitourinary syndrome of lactation", which describes genital, urinary and sexual symptoms that may be linked partly to the temporary hormonal changes associated with breastfeeding. However, not every symptom after childbirth has the same cause. Pain from scars, pelvic floor problems, infections, skin conditions, urinary disorders, tiredness, anxiety and relationship difficulties may also contribute and should be assessed. The article proposes a practical approach for healthcare professionals. Women should be asked directly and sensitively about dryness, pain, urinary symptoms and the effect on their wellbeing. Treatment should be tailored to the main cause and may include information and reassurance, gentle vulval care, lubricants, vaginal moisturisers, pelvic floor physiotherapy and sexual counselling. Low-dose vaginal oestrogen may be a reasonable option for persistent or more troublesome symptoms after an individual discussion of benefits, uncertainties and breastfeeding circumstances. Other hormonal treatments, such as vaginal prasterone, require more research during breastfeeding. Recognising these symptoms does not mean that breastfeeding is harmful. It means that breastfeeding support should also include the mother's physical comfort, sexual health and quality of life. OABL- eng OTO - NOTNLM OT - breastfeeding OT - dyspareunia OT - fourth trimester OT - genitourinary syndrome of lactation OT - hypoestrogenism OT - lactation OT - postpartum period OT - sexual health OT - urinary symptoms OT - vulvovaginal symptoms COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/09/16 17:36 MHDA- 2026/09/16 17:37 CRDT- 2026/09/16 16:43 PHST- 2026/09/16 17:37 [medline] PHST- 2026/09/16 17:36 [pubmed] PHST- 2026/09/16 16:43 [entrez] AID - 10.1177/17455057261490606 [doi] PST - ppublish SO - Womens Health (Lond). 2026 Jan-Dec;22:17455057261490606. doi: 10.1177/17455057261490606. Epub 2026 Sep 16. PMID- 42748414 OWN - NLM STAT- Publisher LR - 20261027 IS - 1464-5491 (Electronic) IS - 0742-3071 (Linking) DP - 2026 Sep 16 TI - Family meals for future health: A life-course approach to type 2 diabetes risk reduction after gestational diabetes. LID - e70476 [pii] LID - 10.1111/dme.70476 [doi] AB - AIMS: Gestational diabetes (GDM) more than doubles maternal and child risk of type 2 diabetes (T2D). Post-GDM, a life-course approach to T2D risk reduction includes family nutrition-focused health promotion. This study explores mothers' perceptions of the role of family meals in T2D risk reduction post-GDM, and brief messages to promote optimal nutrition-related behaviours during family meals. METHODS: Fourteen qualitative, semi-structured online interviews were conducted with mothers aged 18+ years, living in Australia, with prior GDM and at least one child aged <3 years, recruited via social media. Interviews explored perceptions of family meals and T2D risk and included cognitive debriefing and refinement of health-promoting family mealtime messages. Reflexive thematic analysis was applied to transcripts. RESULTS: Mothers indicated awareness of elevated T2D risk. Four themes included: Mothers place high value and expectations on family meals; Balancing individual and collective health and well-being needs post-GDM; an opportunity for family health beyond T2D risk reduction; and supports required to engage in family meals for future health. Mothers perceived the messages as relevant and mostly acceptable. Mothers liked how messages normalised mealtime challenges, though some suggested adaptations conflicted with best-practice guidelines. Mothers preferred online or physical message delivery (e.g. videos, posters), via credible sources (e.g. health professionals) and with practical resources (e.g. recipes). CONCLUSIONS: Post-GDM, mealtimes appear feasible and acceptable for supporting T2D risk reduction in families. Acceptability and relevance of messages highlight their potential for supporting family health, although how to support best practice remains challenging. Implementation pathways and ways to action messages may require the inclusion of practical resources. CI - (c) 2026 The Author(s). Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. FAU - Litterbach, Eloise AU - Litterbach E AUID- ORCID: 0000-0002-4618-1068 AD - School of Psychology, Deakin University, Geelong, Victoria, Australia. AD - The Australian Centre for Behavioural Research in Diabetes, Diabetes Victoria, Carlton, Victoria, Australia. AD - Deakin Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia. FAU - Spence, Alison C AU - Spence AC AUID- ORCID: 0000-0001-9029-1718 AD - Deakin Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Middleton, Georgia AU - Middleton G AUID- ORCID: 0000-0003-2456-9122 AD - Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia. FAU - Speight, Jane AU - Speight J AUID- ORCID: 0000-0002-1204-6896 AD - School of Psychology, Deakin University, Geelong, Victoria, Australia. AD - The Australian Centre for Behavioural Research in Diabetes, Diabetes Victoria, Carlton, Victoria, Australia. AD - Deakin Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia. FAU - Holmes-Truscott, Elizabeth AU - Holmes-Truscott E AUID- ORCID: 0000-0001-9139-4663 AD - School of Psychology, Deakin University, Geelong, Victoria, Australia. AD - The Australian Centre for Behavioural Research in Diabetes, Diabetes Victoria, Carlton, Victoria, Australia. AD - Deakin Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia. LA - eng GR - Deakin University's Institute for Physical Activity and Nutrition/ GR - Deakin Institute for Health Transformation/ PT - Journal Article DEP - 20260916 PL - England TA - Diabet Med JT - Diabetic medicine : a journal of the British Diabetic Association JID - 8500858 SB - IM OTO - NOTNLM OT - co-design OT - family OT - gestational diabetes OT - health promotion OT - mealtimes OT - prevention OT - women EDAT- 2026/09/16 17:36 MHDA- 2026/09/16 17:36 CRDT- 2026/09/16 16:43 PHST- 2026/08/01 00:00 [revised] PHST- 2026/01/21 00:00 [received] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/09/16 17:36 [pubmed] PHST- 2026/09/16 17:36 [medline] PHST- 2026/09/16 16:43 [entrez] AID - e70476 [pii] AID - 10.1111/dme.70476 [doi] PST - aheadofprint SO - Diabet Med. 2026 Sep 16:e70476. doi: 10.1111/dme.70476. PMID- 42747888 OWN - NLM STAT- Publisher LR - 20260916 IS - 1525-6073 (Electronic) IS - 0742-0528 (Linking) DP - 2026 Sep 16 TI - Associations between adherence to 24-hour movement guidelines and parameters of the rest-activity rhythm among preschool-aged children: An exploratory analysis. PG - 1-9 LID - 10.1080/07420528.2026.2732187 [doi] AB - This exploratory cross-sectional secondary analysis examined associations between 24-hour movement behaviors and rest-activity rhythm (RAR) among preschoolers using baseline data from 84 children aged 3.0-5.9 years in a randomized controlled trial. Accelerometer data were processed using R package GGIR to derive time-use composition and cut-point-free metrics (average acceleration and intensity gradient). RAR was characterized by relative amplitude (RA), inter-daily stability (IS), intra‑daily variability (IV), and the circadian function index (CFI). In generalized linear models adjusted for age, sex, body mass index z-score, parental education level, and the number of valid accelerometer wear days, with false discovery rate (FDR) correction, more sedentary behavior relative to other behaviors was associated with lower IS (beta = -0.185; 95% confidence interval [CI]: -0.281, -0.089), higher IV (beta = 0.249; 95% CI: 0.117, 0.380), and lower CFI (beta = -0.252; 95% CI: -0.338, -0.166). In contrast, more light-intensity physical activity was associated with lower IV (beta = -0.324; 95% CI: -0.547, -0.100), and higher CFI (beta = 0.239; 95% CI: 0.111, 0.368). Higher average acceleration was associated with higher CFI (beta = 0.005; 95% CI: 0.002, 0.008). These preliminary findings suggest that higher relative light‑intensity physical activity and lower relative sedentary behavior were associated with healthier RAR in preschoolers. These potential associations warrant further investigation in future confirmatory studies. FAU - Huang, Xiao-Qi AU - Huang XQ AUID- ORCID: 0009-0000-0793-9764 AD - Department of Sports and Health Sciences, Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Hong Kong, China. FAU - Feng, Jie AU - Feng J AD - Faculty of Sports Science, Ningbo University, Ningbo, China. FAU - Huang, Wendy Yajun AU - Huang WY AUID- ORCID: 0000-0003-3995-1121 AD - Department of Sports and Health Sciences, Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Hong Kong, China. AD - Dr Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Hong Kong, China. LA - eng PT - Journal Article DEP - 20260916 PL - England TA - Chronobiol Int JT - Chronobiology international JID - 8501362 SB - IM OTO - NOTNLM OT - Physical activity OT - preschooler OT - rest-activity rhythm OT - sedentary behavior OT - sleep EDAT- 2026/09/16 17:36 MHDA- 2026/09/16 17:36 CRDT- 2026/09/16 11:55 PHST- 2026/09/16 17:36 [medline] PHST- 2026/09/16 17:36 [pubmed] PHST- 2026/09/16 11:55 [entrez] AID - 10.1080/07420528.2026.2732187 [doi] PST - aheadofprint SO - Chronobiol Int. 2026 Sep 16:1-9. doi: 10.1080/07420528.2026.2732187. PMID- 42747779 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261010 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 36 IP - 10 DP - 2026 Oct TI - Ethical Dimensions of Bariatric Surgery: A Narrative Review of Principles, Challenges, and Practice Implications. PG - 5498-5509 LID - 10.1007/s11695-026-08933-6 [doi] AB - Metabolic and bariatric surgery (MBS) is among the most effective interventions for severe obesity, with contemporary outcomes best reported as percentage total weight loss (%TWL), yet it raises ethical challenges distinct from many other surgical disciplines. This SANRA-guided narrative review synthesizes ethical issues across the adult bariatric patient journey using Beauchamp and Childress' four principles: autonomy, beneficence, non-maleficence, and justice. Key tensions include safeguarding consent validity amid obesity stigma and desperation bias; balancing patient autonomy with assessment of co-occurring psychiatric conditions, including a reported five-year cumulative incidence of new alcohol use disorder symptoms of approximately 21% after Roux-en-Y gastric bypass; addressing long-term nutritional, psychological, and follow-up obligations; adapting communication for collectivist contexts; and engaging the implications of obesity management medications, telemedicine, and artificial intelligence. Ethical bariatric practice requires multimodal consent, individualized multidisciplinary candidacy assessment, equity-oriented access policies, and durable systems for long-term postoperative care. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Soltani, Hamid Reza AU - Soltani HR AUID- ORCID: 0000-0002-5045-978X AD - Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Islamic Republic of Iran. hrsgmed@yahoo.com. FAU - Toolabi, Karamollah AU - Toolabi K AD - Department of Minimally Invasive and Bariatric Surgery, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. FAU - Sadat-Safavi, Seyed Abbas AU - Sadat-Safavi SA AD - Department of Minimally Invasive and Bariatric Surgery, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. FAU - Najjari, Khosrow AU - Najjari K AD - Department of Minimally Invasive and Bariatric Surgery, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. FAU - Latif, Amirhossein AU - Latif A AUID- ORCID: 0000-0002-8248-7662 AD - Department of Minimally Invasive and Bariatric Surgery, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 SB - IM MH - Humans MH - *Bariatric Surgery/ethics MH - *Obesity, Morbid/surgery/psychology MH - Personal Autonomy MH - Informed Consent/ethics MH - Beneficence MH - Social Stigma MH - Ethical Dilemmas OTO - NOTNLM OT - Bariatric surgery OT - Ethics, medical OT - Health equity OT - Informed consent OT - Metabolic surgery OT - Obesity OT - Personal autonomy OT - Social stigma COIS- Declarations. Ethics Approval and Consent to Participate: This study is a narrative review of previously published literature and did not involve human participants, animal subjects, or identifiable patient data. Accordingly, ethical approval was not required, and no patient consent was obtained. Consent for Publication: Not applicable. Patient and Public Involvement Statement: Patients and members of the public were not directly involved in this narrative review. Future empirical and consensus-based work should include patient and public involvement to ensure that bariatric ethics frameworks reflect patient priorities, decisional experiences, follow-up barriers, and perceptions of equitable care. AI Tool Use Disclosure: AI-assisted writing tools were used during the preparation of this manuscript for language editing and structural refinement. All intellectual content, interpretation, and conclusions are the sole responsibility of the authors. The authors have reviewed and take full responsibility for the final text. Competing Interests: The authors declare no competing interests. Clinical Trial Registration: Not applicable. EDAT- 2026/09/16 17:36 MHDA- 2026/10/07 17:33 CRDT- 2026/09/16 11:41 PHST- 2026/06/08 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/08/20 00:00 [revised] PHST- 2026/10/07 17:33 [medline] PHST- 2026/09/16 17:36 [pubmed] PHST- 2026/09/16 11:41 [entrez] AID - 10.1007/s11695-026-08933-6 [pii] AID - 10.1007/s11695-026-08933-6 [doi] PST - ppublish SO - Obes Surg. 2026 Oct;36(10):5498-5509. doi: 10.1007/s11695-026-08933-6. Epub 2026 Sep 16. PMID- 42747402 OWN - NLM STAT- Publisher LR - 20260916 IS - 1876-3405 (Electronic) IS - 1876-3405 (Linking) DP - 2026 Sep 16 TI - An exploratory study to describe the growth and neurodevelopmental status of low birthweight infants in the context of a community-based mother-to-mother peer support implementation program in Kenya. LID - ihag076 [pii] LID - 10.1093/inthealth/ihag076 [doi] AB - BACKGROUND: This article examines changes in mothers' knowledge of low birthweight (LBW; <2500 g) infant care practices in a study assessing the feasibility and acceptability of peer mother support post-discharge, explores the acceptability of the intervention among mothers and healthcare workers and describes the post-intervention growth and neurodevelopmental status of the LBW infants. METHODS: A mixed methods exploratory study, using questionnaires, semi-structured interviews and focus group discussions with mothers, healthcare providers and peer mothers was conducted in three health facilities in Homa Bay County, western Kenya. Peer mothers delivered the interventions (including breastfeeding support) to mother-LBW infant pairs at 24 h post-discharge and six other time points until 3 months after birth. Infant anthropometric assessments were done at birth, discharge and 3 months after birth, while neurodevelopmental assessment was done only at 3 months using the Malawi Developmental Assessment Tool. Descriptive statistics were used to analyse the quantitative data. A thematic framework was used to analyse the qualitative data. RESULTS: Sixty mother-LBW infant pairs were enrolled in the study, but only 55 were included in the analysis because 5 mothers and their LBW infants were lost to follow-up. The median birthweight was 2050 g, median discharge weight was 2100 g and median weight gain 3 months after birth was 2820 g. The weight-for-age z-scores increased by 0.3 from birth to 3 months; similarly, the weight-for-length z-score increased by approximately 0.2. However, the length for age Z-score decreased by 0.3. At 3 months, 96% (n=53) of LBW infants had achieved their gross motor, 71% (n=42) fine motor, 89% (n=49) language and 100% social milestones. The intervention improved maternal knowledge and practice of recommended LBW infant care strategies, promoted resilience and enhanced family relationships. CONCLUSION: This exploratory study suggests that a mother-to-mother peer support intervention improved maternal knowledge, care practices and empowerment in the post-discharge care of LBW infants in a resource-limited setting. Further refinement and rigorous evaluation are needed to generate robust evidence on its effectiveness and impact on growth and neurodevelopmental outcomes. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. FAU - Nabwera, Helen M AU - Nabwera HM AUID- ORCID: 0000-0003-1056-729X AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. AD - Aga Khan University, Centre of Excellence for Women and Child Health, P.O. Box 30270 - 00100, Nairobi, Kenya. FAU - Parekh, Meera AU - Parekh M AUID- ORCID: 0009-0004-5132-0220 AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. AD - University of Liverpool, Ashton Street, Liverpool L69 3GE, UK. FAU - Gaetean, Brezesky K AU - Gaetean BK AD - London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. FAU - Achieng Were, Florence AU - Achieng Were F AD - KEMRI-Centre for Global Health Research, P.O. Box 1578-40100, Kisumu, Kenya. FAU - Agbla, Schadrac AU - Agbla S AD - University of Liverpool, Ashton Street, Liverpool L69 3GE, UK. AD - London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. FAU - Barsosio, Hellen C AU - Barsosio HC AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. AD - KEMRI-Centre for Global Health Research, P.O. Box 1578-40100, Kisumu, Kenya. FAU - Tindi, Linda AU - Tindi L AD - Homa Bay County Teaching and Referral Hospital, 52-40300 Homa Bay, Kenya. FAU - Boga, Mwanamvua AU - Boga M AD - KEMRI-Wellcome Trust Research Programme, P.O. Box 230-80108, Kilifi, Kenya. FAU - Kimani, Mary AU - Kimani M AD - Action Against Hunger, Old Dagoretti Estate Gate, off Ngong Road, Nairobi, Kenya. FAU - Juma, Dan AU - Juma D AD - KEMRI-Centre for Global Health Research, P.O. Box 1578-40100, Kisumu, Kenya. FAU - Kiige, Laura AU - Kiige L AD - UNICEF Kenya, P.O. Box 44145-00100, Nairobi, Kenya. FAU - Manu, Alexander AU - Manu A AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. FAU - Kariuki, Simon AU - Kariuki S AD - KEMRI-Centre for Global Health Research, P.O. Box 1578-40100, Kisumu, Kenya. FAU - Mwangome, Martha K AU - Mwangome MK AUID- ORCID: 0000-0003-4806-1307 AD - KEMRI-Wellcome Trust Research Programme, P.O. Box 230-80108, Kilifi, Kenya. FAU - Pyone, Thidar AU - Pyone T AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. FAU - Gladstone, Melissa AU - Gladstone M AD - University of Liverpool, Ashton Street, Liverpool L69 3GE, UK. FAU - Mathai, Matthews AU - Mathai M AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. LA - eng GR - Liverpool School of Tropical Medicine/ GR - UK Medical Research Council/ GR - MRC/ GR - FCDO/ GR - European Union/ PT - Journal Article DEP - 20260916 PL - England TA - Int Health JT - International health JID - 101517095 SB - IM OTO - NOTNLM OT - Kenya OT - community-based interventions OT - low birthweight infants OT - neurodevelopment OT - peer mothers EDAT- 2026/09/16 11:41 MHDA- 2026/09/16 11:41 CRDT- 2026/09/16 10:44 PHST- 2025/06/09 00:00 [received] PHST- 2026/06/14 00:00 [revised] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/09/16 11:41 [medline] PHST- 2026/09/16 11:41 [pubmed] PHST- 2026/09/16 10:44 [entrez] AID - 8802187 [pii] AID - 10.1093/inthealth/ihag076 [doi] PST - aheadofprint SO - Int Health. 2026 Sep 16:ihag076. doi: 10.1093/inthealth/ihag076. PMID- 42746112 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260917 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Antibiotic-induced gut microbiota dysbiosis in the PICU: mechanisms, clinical outcomes, and management strategies - a narrative review. PG - 1910105 LID - 10.3389/fimmu.2026.1910105 [doi] LID - 1910105 AB - BACKGROUND: Antibiotic exposure is highly prevalent in the paediatric intensive care unit (PICU) and constitutes a major modifiable driver of gut microbiota dysbiosis. However, a systematic synthesis focusing specifically on the PICU population has been lacking. This narrative review addresses how antibiotic exposure drives gut dysbiosis in the PICU, its clinical consequences with emphasis on immunological pathways, and its management. METHODS: This review was informed by a structured search of PubMed, Web of Science, Cochrane Library, and Chinese databases up to June 2026, including studies on antibiotic exposure, microbiota alterations, clinical outcomes, and management in critically ill children. RESULTS: Antibiotic use in PICU children ranges from 58% to 94%, with broad-spectrum and combination therapy being common. Anti-anaerobic antibiotics-particularly piperacillin-tazobactam, meropenem, and clindamycin-cause the most pronounced disruption, as quantified in adult ICU cohorts. In PICU children, clinical consequences include a higher incidence of Clostridioides difficile infection and an increased risk of ventilator-associated pneumonia following carbapenem exposure. Antibiotic stewardship, encompassing de-escalation and avoidance of unnecessary anaerobic coverage, is the first-line microbiota protection strategy. Probiotics reduce ventilator-associated pneumonia and shorten PICU stay, but should not be used routinely in high-risk children. High-fibre enteral nutrition has shown feasibility, whereas postbiotics and faecal microbiota transplantation lack PICU-specific trial data. CONCLUSIONS: Antibiotics are among the most significant modifiable drivers of gut dysbiosis in the PICU, with dose-dependent, class-specific effects. Antibiotic stewardship should be prioritised before any microbiota-directed intervention. Live probiotics require caution in high-risk populations, while non-live interventions are promising but need larger trials. Future research should employ longitudinal, multicentre studies with standardised reporting to elucidate host-microbe interactions in critically ill children. CI - Copyright (c) 2026 Yang, Wang and Peng. FAU - Yang, Cheng AU - Yang C AD - Department of Paediatric Intensive Care Unit Nursing, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Department of Paediatric Intensive Care Unit Nursing, WCSUH-Tianfu.Sichuan Provincial Children's Hospital, Meishan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Wang, Dandan AU - Wang D AD - The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu, China. FAU - Peng, Wentao AU - Peng W AD - Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Department of Nursing, WCSUH-Tianfu.Sichuan Provincial Children's Hospital, Meishan, China. LA - eng PT - Journal Article PT - Review DEP - 20260901 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - *Dysbiosis/chemically induced/therapy MH - *Gastrointestinal Microbiome/drug effects MH - *Intensive Care Units, Pediatric MH - *Anti-Bacterial Agents/adverse effects MH - Child MH - Critical Illness PMC - PMC13575818 OTO - NOTNLM OT - PICU OT - antibiotic stewardship OT - dysbiosis OT - gut microbiota OT - microbiome OT - sepsis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/16 11:41 MHDA- 2026/09/16 11:42 PMCR- 2026/09/01 CRDT- 2026/09/16 05:32 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/16 11:42 [medline] PHST- 2026/09/16 11:41 [pubmed] PHST- 2026/09/16 05:32 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1910105 [doi] PST - epublish SO - Front Immunol. 2026 Sep 1;17:1910105. doi: 10.3389/fimmu.2026.1910105. eCollection 2026. PMID- 42745272 OWN - NLM STAT- Publisher LR - 20261018 IS - 1469-8749 (Electronic) IS - 0012-1622 (Linking) DP - 2026 Sep 15 TI - International consensus recommendations for identifying malnutrition in children with neurological impairment. LID - 10.1111/dmcn.70507 [doi] AB - Children with neurological impairment (CNI) are at increased risk of malnutrition because of functional, medical, and socioeconomic challenges. However, difficulties in obtaining reliable anthropometric measurements and differences in body composition limit the usefulness of conventional nutritional indicators. We convened an international multidisciplinary panel named the Promoting International Collaboration for Nutrition in Neurological Impairment in Children (PICNNIC) workgroup. Our aim was to review the literature and develop criteria for identifying malnutrition in CNI. A structured literature review (2012-2025) was conducted across multiple databases, which identified 177 articles for inclusion. Evidence was synthesized by domain experts and recommendations were developed using a modified Delphi process, with predefined thresholds for agreement (median score at least 7 and at least 80% consensus). All (n = 18) authors, except the medical librarian, voted and all recommendations reached consensus in the initial round. The 28 recommendations, with the accompanying algorithm, offer pediatricians and nutrition care professionals a structured, multimodal approach to identifying malnutrition in CNI. CI - (c) 2026 The Author(s). Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press. FAU - Vermilyea, Sarah AU - Vermilyea S AUID- ORCID: 0000-0003-0569-9968 AD - Clinical Nutrition, Saint Joe's, Cincinnati, OH, USA. FAU - Wolff, Jodi AU - Wolff J AUID- ORCID: 0009-0009-4894-0329 AD - Baxter Healthcare, Deerfield, IL, USA. FAU - Rempel, Gina AU - Rempel G AUID- ORCID: 0000-0001-8632-3406 AD - Department of Pediatrics and Child Health, Rehabilitation and Complex Care, Children's Hospital Winnipeg, University of Manitoba, Winnipeg, MB, Canada. FAU - Hulst, Jessie M AU - Hulst JM AUID- ORCID: 0000-0002-4899-7343 AD - Division of Pediatric Gastroenterology, Hepatology & Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada. AD - Department of Pediatrics and Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada. FAU - Huysentruyt, Koen AU - Huysentruyt K AD - Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium. FAU - Neudecker, Mandy AU - Neudecker M AD - University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH, USA. FAU - Kennedy, Denise AU - Kennedy D AUID- ORCID: 0000-0002-2235-2854 AD - First Community Health and Care, Surrey, UK. FAU - Marchand, Valerie AU - Marchand V AD - Centre Hospitalier Universitaire Sainte-Justine, Universite de Montreal Montreal, QC, Canada. FAU - Ochoa-Ortiz, Erika AU - Ochoa-Ortiz E AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Centro de Investigacion y Educacion en Nutricion (CIENutrition), Bogota, Colombia. FAU - Stevenson, Richard D AU - Stevenson RD AUID- ORCID: 0000-0003-3925-8829 AD - University of Virginia School of Medicine and UVA Health Children's, Charlottesville, VA, USA. CN - Promoting International Collaboration for Nutrition in Neurological Impairment in Children (PICNNIC) Working Group LA - eng GR - Nestle Global/ PT - Journal Article DEP - 20260915 PL - England TA - Dev Med Child Neurol JT - Developmental medicine and child neurology JID - 0006761 SB - IM FIR - Lourens, Lucinda IR - Lourens L FIR - Conaway, Mark IR - Conaway M FIR - Desai, Tejas S IR - Desai TS FIR - Ruiz Brunner, Mercedes IR - Ruiz Brunner M FIR - Vargas, Nathalia Sanchez IR - Vargas NS FIR - Tenorio, Valeria Martinez IR - Tenorio VM FIR - Bell, Kristie L IR - Bell KL FIR - Romano, Claudio IR - Romano C FIR - Grossberg, Richard IR - Grossberg R EDAT- 2026/09/16 05:36 MHDA- 2026/09/16 05:36 CRDT- 2026/09/16 03:10 PHST- 2026/07/29 00:00 [revised] PHST- 2026/06/03 00:00 [received] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/09/16 05:36 [pubmed] PHST- 2026/09/16 05:36 [medline] PHST- 2026/09/16 03:10 [entrez] AID - 10.1111/dmcn.70507 [doi] PST - aheadofprint SO - Dev Med Child Neurol. 2026 Sep 15. doi: 10.1111/dmcn.70507. PMID- 42744534 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260915 IS - 2530-0180 (Electronic) IS - 2530-0180 (Linking) VI - 73 IP - 7 DP - 2026 Aug-Sep TI - Hypothalamic-pituitary axis MRI findings in pediatric endocrine disorders: A retrospective study. PG - 501781 LID - S2530-0180(26)00116-2 [pii] LID - 10.1016/j.endien.2026.501781 [doi] AB - BACKGROUND: Magnetic resonance imaging (MRI) of the hypothalamic-pituitary axis (HPA) is widely used in pediatric endocrinology, yet the clinical relevance of structural abnormalities remains debated. OBJECTIVE: To assess the diagnostic yield of HPA MRI in children with endocrine disorders and identify clinical/hormonal predictors of clinically relevant findings. METHODS: We retrospectively analysed a total of 202 patients (1 month to 17 years) evaluated from 2018 through 2023 for suspected HPA dysfunction. Diagnostic groups included isolated growth hormone deficiency (IGHD), multiple pituitary hormone deficiency (MPHD), short stature without growth hormone deficiency (SSWGD), central precocious puberty (CPP), central diabetes insipidus (CDI), and pituitary hypersecretion syndrome (PHS). MRI findings were classified as normal, relevant, or incidental. Logistic regression and ROC analysis were used to identify predictive factors. RESULTS: Abnormal MRI findings were identified in 29.2% of patients (59/202); 14.9% (30/202) were clinically relevant and 14.4% (29/202), incidental. Diagnostic yield (any abnormal finding) was highest in MPHD (100%) and CDI (87.5%), followed by PHS (40.0%), SSWGD (30.8%), CPP (26.4%) and IGHD (23.2%). In IGHD, lower GH peaks on the exercise-propranolol test were significantly associated with abnormal MRI findings (OR, 3.98; 95%CI, 1.53-10.30; P=.026). There were no predictors for CPP. Incidental lesions were most common in CPP and IGHD. CONCLUSIONS: MRI showed the highest diagnostic yield in MPHD and CDI. In IGHD, lower GH peak values may help guide selective imaging, while in CPP the lack of reliable predictors supports routine MRI. Multidisciplinary interpretation remains essential to contextualise incidental findings. CI - Copyright (c) 2026 SEEN and SED. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Dominguez-Garcia, Angela AU - Dominguez-Garcia A AD - Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Canary Islands, Spain. Electronic address: domgarang@gmail.com. FAU - Navarro-Dominguez, David AU - Navarro-Dominguez D AD - Faculty of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Quinteiro-Gonzalez, Sofia AU - Quinteiro-Gonzalez S AD - Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Lopez-Lopez, Sara AU - Lopez-Lopez S AD - Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Cabrera-Guedes, Maria F AU - Cabrera-Guedes MF AD - Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Novoa-Medina, Yeray AU - Novoa-Medina Y AD - Pediatric Endocrinology Unit, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Canary Islands, Spain; Asociacion Canaria para la Investigacion Pediatrica (ACIP Canarias), Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain; Instituto Universitario de Investigacion Biomedica y Sanitaria (IUIBS), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain. LA - eng PT - Journal Article PL - Spain TA - Endocrinol Diabetes Nutr (Engl Ed) JT - Endocrinologia, diabetes y nutricion JID - 101717565 SB - IM MH - Humans MH - Retrospective Studies MH - *Magnetic Resonance Imaging MH - Female MH - Adolescent MH - *Hypothalamo-Hypophyseal System/diagnostic imaging/physiopathology MH - Child MH - *Endocrine System Diseases/diagnostic imaging MH - Male MH - Child, Preschool MH - Infant OTO - NOTNLM OT - Central precocious puberty OT - Diabetes insipidus OT - Diabetes insipida central OT - Deficit de hormona de crecimiento OT - Eje hipotalamo-hipofisario OT - Growth hormone deficiency OT - Hypothalamic-pituitary axis OT - Magnetic resonance imaging OT - Pubertad precoz central OT - Resonancia magnetica EDAT- 2026/09/15 23:35 MHDA- 2026/09/15 23:36 CRDT- 2026/09/15 20:56 PHST- 2025/10/28 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/09/15 23:36 [medline] PHST- 2026/09/15 23:35 [pubmed] PHST- 2026/09/15 20:56 [entrez] AID - S2530-0180(26)00116-2 [pii] AID - 10.1016/j.endien.2026.501781 [doi] PST - ppublish SO - Endocrinol Diabetes Nutr (Engl Ed). 2026 Aug-Sep;73(7):501781. doi: 10.1016/j.endien.2026.501781. PMID- 42744207 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1532-3064 (Electronic) IS - 0954-6111 (Linking) VI - 263 DP - 2026 Nov TI - Identification of modifiable risk factors to prevent atopic wheeze in infants born to mothers with asthma: a cohort study. PG - 109154 LID - S0954-6111(26)00523-8 [pii] LID - 10.1016/j.rmed.2026.109154 [doi] AB - OBJECTIVE: Maternal asthma is the leading risk factor for children developing wheeze and allergic disease in early life. We aimed to describe atopic phenotypes in infants of mothers with asthma and assess which early-life factors were associated with these phenotypes. METHODS: Participants were part of the Breathing for Life Trial Birth Cohort, which recruited pregnant women with asthma prior to 23 weeks gestation (n = 549). Parents completed a validated questionnaire about their child's wheeze requiring healthcare utilization (hospitalization, emergency department visits, consultant referral and primary care visits for wheeze, asthma medication use), respiratory infections, eczema and rhinitis at 12 months of age. Latent class analysis was used to identify the atopic phenotypes among infants. Logistic regression assessed early-life risk factors including maternal characteristics, perinatal factors and environmental exposures. RESULTS: Three phenotypes were identified: low-atopy/low-wheeze (35.2%), atopic mild-wheeze (38.6%) and atopic high-wheeze (26.2%). Maternal obesity (aOR 3.22 95% CI 1.90, 5.44), smoking in pregnancy (aOR 2.60 95%CI 1.36, 4.97), asthma exacerbations in pregnancy (aOR 1.98 95%CI 1.30, 3.02), preterm birth (aOR 2.50 1.34, 4.66), and NICU admission (aOR 2.71 95%CI 1.14, 6.46) were associated with atopic high-wheeze compared to low-atopy/low-wheeze. Maternal obesity (aOR 2.02 95%CI 1.26, 3.24) and smoking in pregnancy (aOR 2.55 95%CI 1.37, 4.72) were associated with atopic mild-wheeze compared to low-atopy/low-wheeze. CONCLUSION: Multiple modifiable factors (maternal obesity, smoking and maternal asthma exacerbations) and adverse birth outcomes are associated with the severity of wheeze in infants of mothers with asthma, providing an opportunity for intervention to prevent later childhood asthma. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Liu, Jihong AU - Liu J AD - Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Brew, Bronwyn K AU - Brew BK AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. Electronic address: bronwyn.brew@newcastle.edu.au. FAU - Zhao, Xingpei AU - Zhao X AD - Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Collison, Adam AU - Collison A AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. FAU - Jensen, Megan E AU - Jensen ME AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. FAU - Mattes, Joerg AU - Mattes J AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia; Department of Respiratory Medicine, John Hunter Children's Hospital, Newcastle, NSW, Australia. FAU - Robinson, Paul D AU - Robinson PD AD - Children's Health and Environment Program, Child Health Research Centre, University of Queensland, QLD, Australia; Department of Respiratory Medicine, Queensland Children's Hospital, QLD, Australia. FAU - Sly, Peter D AU - Sly PD AD - Children's Health and Environment Program, Child Health Research Centre, University of Queensland, QLD, Australia. FAU - Gibson, Peter G AU - Gibson PG AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia; Department of Respiratory & Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia. FAU - Murphy, Vanessa E AU - Murphy VE AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. LA - eng PT - Journal Article DEP - 20260915 PL - England TA - Respir Med JT - Respiratory medicine JID - 8908438 SB - IM MH - Humans MH - Female MH - *Asthma/complications/epidemiology MH - *Respiratory Sounds/etiology MH - Pregnancy MH - Risk Factors MH - Infant MH - Adult MH - *Prenatal Exposure Delayed Effects/prevention & control MH - Cohort Studies MH - Smoking/adverse effects MH - Infant, Newborn MH - Phenotype MH - *Pregnancy Complications/epidemiology MH - Male MH - Developmental Origins of Health and Disease MH - Mothers OTO - NOTNLM OT - Asthma OT - Infant OT - Maternal OT - Obesity OT - Phenotypes OT - Smoking OT - Wheeze COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Bronwyn Brew reports financial support was provided by National Health and Medical Research Council. Vanessa Murphy reports financial support was provided by Australian Government Medical Research Future Fund. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/15 23:35 MHDA- 2026/10/23 23:31 CRDT- 2026/09/15 19:21 PHST- 2026/03/19 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/10/23 23:31 [medline] PHST- 2026/09/15 23:35 [pubmed] PHST- 2026/09/15 19:21 [entrez] AID - S0954-6111(26)00523-8 [pii] AID - 10.1016/j.rmed.2026.109154 [doi] PST - ppublish SO - Respir Med. 2026 Nov;263:109154. doi: 10.1016/j.rmed.2026.109154. Epub 2026 Sep 15. PMID- 42743207 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 9 DP - 2026 TI - Performance evaluation of a direct chemiluminescence assay for 25-hydroxyvitamin D and its application in assessing vitamin D status among reproductive-age women in southeastern China. PG - e0356809 LID - 10.1371/journal.pone.0356809 [doi] LID - e0356809 AB - BACKGROUND: Vitamin D deficiency is a global public health concern, and women of reproductive age represent a particularly vulnerable population. Accurate measurement of serum 25-hydroxyvitamin D [25(OH)D] is therefore essential for reliable clinical assessment. This study aimed to evaluate the analytical performance of the Innodx vitamin D assay for 25(OH)D measurement and to investigate the prevalence of vitamin D deficiency among women of reproductive age in southeastern China. METHODS: This cross-sectional study enrolled women of reproductive age (20-45 years) who sought medical services at Xiamen Maternal and Child Health Hospital in China between November 2023 and September 2025. Serum 25(OH)D levels were measured to determine vitamin D status using the Innodx vitamin D assay (Xiamen Innodx Biotech Co., Ltd., Xiamen, China). The analytical performance of the assay was validated according to Clinical and Laboratory Standards Institute (CLSI) guidelines, covering precision, accuracy, linearity, and interference. A method comparison was performed against liquid chromatography-tandem mass spectrometry (LC-MS/MS) and the Roche electrochemiluminescence assay. Based on the measured levels, vitamin D status was categorized as deficient (< 20 ng/mL), insufficient (>/=20, < 30 ng/mL), or sufficient (>/= 30 ng/mL). RESULTS: The intra-assay coefficients of variation (CV) were 3.18%, 2.09%, and 1.86% at three concentration levels (5, 25, and 100 ng/mL), while intermediate precision CVs were 4.34%, 3.64%, and 3.17%, respectively. Accuracy testing showed bias of 4.20% and 3.26% at 20 and 50 ng/mL. The assay demonstrated excellent linearity (R2 = 0.998) across the range of 4.0-150.0 ng/mL. No significant interference was observed from hemoglobin (100 mg/dL), bilirubin (40 mg/dL), triglycerides (400 mg/dL), or rheumatoid factor (600 IU/mL). In method comparison with LC-MS/MS, the Innodx vitamin D assay demonstrated strong concordance with a Pearson correlation coefficient of r = 0.970. When compared with the Roche vitamin D assay, the Innodx showed better correlation with LC-MS/MS. Among 495 women, the mean 25(OH)D concentration was 20.50 +/- 7.88 ng/mL, with 88.9% (95% CI: 86.1%, 91.7%) having vitamin D deficiency or insufficiency. Women aged 35 years: 23.72 +/- 8.56 ng/mL) (P < 0.05). CONCLUSION: The Innodx vitamin D chemiluminescence assay demonstrated satisfactory analytical performance for clinical use. Our findings reveal a high prevalence of vitamin D deficiency among reproductive-age women in southeastern China, particularly in younger age groups, highlighting the need for public health interventions. CI - Copyright: (c) 2026 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Zhu, Min AU - Zhu M AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Chen, Tianhua AU - Chen T AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Cao, Jiali AU - Cao J AUID- ORCID: 0000-0002-6286-5574 AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Luo, Linhua AU - Luo L AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Lin, Minchuan AU - Lin M AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Huang, Haiying AU - Huang H AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Xu, Weiwei AU - Xu W AD - Medical Laboratory of Xiamen Humanity Hospital Fujian Medical University, Xiamen, China. FAU - Li, Lihua AU - Li L AD - Xiamen Innodx Biotech Co., Ltd, Xiamen, China. FAU - Xie, Hongbin AU - Xie H AD - Department of Health Management, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Chen, Xiaoli AU - Chen X AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Ye, Huiming AU - Ye H AUID- ORCID: 0000-0003-2069-3644 AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. LA - eng PT - Journal Article DEP - 20260915 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - Female MH - *Vitamin D/analogs & derivatives/blood MH - Adult MH - China/epidemiology MH - *Vitamin D Deficiency/blood/epidemiology/diagnosis MH - Middle Aged MH - *Luminescent Measurements/methods MH - Cross-Sectional Studies MH - Young Adult MH - Tandem Mass Spectrometry PMC - PMC13577506 COIS- Lihua Li is employed by Xiamen Innodx Biotech Co., Ltd. Xiamen Innodx Biotech Co., Ltd. provided support in the form of salary for author Lihua Li. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The other authors declare no competing interests. EDAT- 2026/09/15 18:07 MHDA- 2026/09/15 18:08 PMCR- 2026/09/15 CRDT- 2026/09/15 13:53 PHST- 2026/04/14 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/09/15 18:08 [medline] PHST- 2026/09/15 18:07 [pubmed] PHST- 2026/09/15 13:53 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - PONE-D-26-17612 [pii] AID - 10.1371/journal.pone.0356809 [doi] PST - epublish SO - PLoS One. 2026 Sep 15;21(9):e0356809. doi: 10.1371/journal.pone.0356809. eCollection 2026. PMID- 42742750 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20261008 IS - 1437-9813 (Electronic) IS - 0179-0358 (Linking) VI - 42 IP - 1 DP - 2026 Sep 15 TI - Comparison of long-term outcomes and nutritional status between primary and non-primary fascial closure in omphalocele. LID - 406 [pii] LID - 10.1007/s00383-026-06642-w [doi] AB - PURPOSE: Operative strategies for omphalocele vary, and long-term outcomes remain limited. We aimed to compare postoperative and long-term outcomes of omphalocele repair with primary versus non-primary fascial closure. METHODS: A retrospective study of omphalocele at 2 institutions between 2006 and 2021 was conducted. After excluding patients with genetic disorders and severe associated anomalies, 41 patients (15 primary fascial and 26 non-primary fascial closures) were reviewed. RESULTS: Although there were no significant differences in defect size or liver herniation, non-primary fascial closure was significantly associated with a concomitant non-cyanotic cardiac anomaly. Time to first enteral feeding and length of hospital stay were significantly longer in non-primary fascial closure. For long-term outcomes, non-primary fascial closure was associated with significantly higher rates of failure to thrive during infancy (76% vs. 40%) and toddlerhood (62.5% vs. 23.1%). However, there were no significant differences in ventral hernia, respiratory, or neurodevelopmental problems. CONCLUSION: Non-primary fascial closure is associated with higher rates of failure to thrive, underscoring need for long-term follow-up of nutritional status; however, the higher incidence of cardiac anomalies in this group may reflect a bias toward selecting this closure technique. When feasible and not complicated, primary fascial closure might be preferred option for omphalocele. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Burapharat, Poohpathra AU - Burapharat P AD - Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Khon Kaen University, 123 Mittraphap Road, Khon Kaen, 40002, Thailand. FAU - Srisan, Nimmita AU - Srisan N AD - Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, 10330, Thailand. FAU - Thaiwatcharamas, Kanokrat AU - Thaiwatcharamas K AD - Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Khon Kaen University, 123 Mittraphap Road, Khon Kaen, 40002, Thailand. FAU - Tanming, Patchareeporn AU - Tanming P AD - Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Khon Kaen University, 123 Mittraphap Road, Khon Kaen, 40002, Thailand. FAU - Aroonsaeng, Dolrudee AU - Aroonsaeng D AD - Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Khon Kaen University, 123 Mittraphap Road, Khon Kaen, 40002, Thailand. FAU - Vejchapipat, Paisarn AU - Vejchapipat P AD - Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, 10330, Thailand. FAU - Chusilp, Sinobol AU - Chusilp S AD - Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Khon Kaen University, 123 Mittraphap Road, Khon Kaen, 40002, Thailand. sinoch@kku.ac.th. LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study DEP - 20260915 PL - Germany TA - Pediatr Surg Int JT - Pediatric surgery international JID - 8609169 SB - IM MH - Humans MH - *Omphalocele/surgery MH - Retrospective Studies MH - Female MH - Male MH - Treatment Outcome MH - *Nutritional Status MH - Infant MH - Infant, Newborn MH - *Fasciotomy/methods MH - *Abdominal Wound Closure Techniques MH - Follow-Up Studies MH - *Hernia, Umbilical/surgery OTO - NOTNLM OT - Failure to thrive OT - Long-term outcome OT - Omphalocele OT - Primary fascial closure COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2026/09/15 18:07 MHDA- 2026/09/15 18:08 CRDT- 2026/09/15 11:22 PHST- 2026/08/27 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/15 18:08 [medline] PHST- 2026/09/15 18:07 [pubmed] PHST- 2026/09/15 11:22 [entrez] AID - 10.1007/s00383-026-06642-w [pii] AID - 10.1007/s00383-026-06642-w [doi] PST - epublish SO - Pediatr Surg Int. 2026 Sep 15;42(1):406. doi: 10.1007/s00383-026-06642-w. PMID- 42740930 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260923 IS - 3086-3910 (Electronic) IS - 3086-3910 (Linking) VI - 52 IP - 3 DP - 2026 TI - Targeted metabolomic analysis of exhaled breath condensate before and after bronchial provocation by eucapnic voluntary hyperventilation in adolescents with asthma: an exploratory study. PG - e20250375 LID - 10.36416/1806-3756/e20250375 [doi] LID - e20250375 AB - OBJECTIVE: To analyze endogenous metabolites in exhaled breath condensate before and after eucapnic voluntary hyperventilation (EVH) in adolescents with asthma with and without exercise-induced bronchoconstriction (EIB). METHODS: This was an exploratory study including 44 adolescents with asthma in the 10- to 20-year age bracket. They were divided into two groups: the group of patients with EIB (n = 25) and that of those without (n = 19). EIB was defined as a >/= 10% reduction in FEV(1) after a six-minute EVH challenge using 5% carbon dioxide. Ventilation was maintained at 21 times the baseline FEV(1). Exhaled breath condensate was collected before EVH and 15-30 min after EVH by using a validated device. Samples were analyzed by proton nuclear magnetic resonance focusing on the region of d1.60-2.00 parts per million. Data were preprocessed by using sum normalization and autoscaling for orthogonal partial least squares discriminant analysis. RESULTS: All participants completed the protocol without adverse events. The mean reduction in FEV(1) was significantly greater in the group of patients with EIB than in that of those without (-25.13% vs. -4.37%; mean difference, -20.76%; 95% CI, -26.45 to -15.07). In the EIB group, responses were classified as mild (n = 15), moderate (n = 9), or severe (n = 1). Post-EVH orthogonal partial least squares discriminant analysis showed significant separation between pre- and post-EVH metabolic profiles in the group of patients with EIB (p < 0.001) but not in that of those without (p = 0.195). The discriminative response in patients with EIB was associated with a marked increase in acetate signal intensity at 1.76 parts per million. CONCLUSIONS: Adolescents with EIB show a distinct metabolic fingerprint that is significantly associated with ventilatory stress. Acetate emerged as a key metabolic differentiator, suggesting a specific biochemical pathway associated with the exercise response and supporting its potential role in precision phenotyping of EIB. CI - (c) 2026 Sociedade Brasileira de Pneumologia e Tisiologia. FAU - de Albuquerque, Claudio Goncalves AU - de Albuquerque CG AUID- ORCID: 0000-0002-1698-7853 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Rizzo, Jose Angelo AU - Rizzo JA AUID- ORCID: 0000-0002-6876-3122 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Rodrigues, Edil de Albuquerque AU - Rodrigues EA AUID- ORCID: 0000-0001-6203-3658 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Silva, Ricardo Oliveira AU - Silva RO AUID- ORCID: 0000-0001-8090-7320 AD - . Laboratorio de Metabonomica e Quimiometria. Departamento de Quimica Fundamental, Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - da Luz, Tatiane Priscila Santos Rodrigues AU - da Luz TPSR AUID- ORCID: 0000-0002-8394-5012 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Correia, Marco Aurelio de Valois AU - Correia MAV AUID- ORCID: 0000-0003-0386-5256 AD - . Programa de Pos-Graduacao em Hebiatria e Programa de Pos-Graduacao Associado em Educacao Fisica, Faculdade de Ciencias Medicas, Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Peixoto, Decio Medeiros AU - Peixoto DM AUID- ORCID: 0000-0003-1779-5762 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. LA - eng PT - Journal Article DEP - 20260813 PL - Brazil TA - Respir Res Clin Pract JT - Respiratory research & clinical practice JID - 9919269228506676 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Hyperventilation/metabolism/physiopathology/diagnosis MH - Male MH - Breath Tests/methods MH - *Metabolomics/methods MH - *Asthma/metabolism/diagnosis/physiopathology MH - *Bronchial Provocation Tests/methods MH - Child MH - *Exhalation/physiology MH - Young Adult MH - *Asthma, Exercise-Induced/metabolism/diagnosis/physiopathology PMC - PMC13568813 OTO - NOTNLM OT - Asthma OT - Breath tests OT - Exercise-induced bronchospasm OT - Metabolomics EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 12:08 PMCR- 2026/08/13 CRDT- 2026/09/15 05:01 PHST- 2025/09/18 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/09/15 12:08 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 05:01 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.36416/1806-3756/e20250375 [doi] PST - epublish SO - Respir Res Clin Pract. 2026 Aug 13;52(3):e20250375. doi: 10.36416/1806-3756/e20250375. eCollection 2026. PMID- 42740390 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 2314-6753 (Electronic) IS - 2314-6745 (Print) VI - 2026 IP - 1 DP - 2026 TI - Olfactory Performance of Children and Adolescents With Type 1 Diabetes: Relationship to Diabetes Duration and Glycemic Control. PG - e8415282 LID - 10.1155/jdr/8415282 [doi] LID - 8415282 AB - BACKGROUND/OBJECTIVES: Olfactory dysfunction is increasingly recognized as a complication of diabetes that negatively impacts eating behavior and quality of life. This study investigates olfactory function in adolescents with Type 1 diabetes and evaluates the impact of disease duration and long-term glycemic control (mean HbA1c) on olfactory performance. METHODS: Olfactory function was assessed using the validated "Sniffin' Sticks" test, which evaluates odor threshold, discrimination, and identification to generate a composite TDI score for diagnosing hyposmia (TDI < 30.75). RESULTS: Hyposmia was identified in 30% of adolescents with Type 1 diabetes, whereas none exhibited anosmia. Overall olfactory performance (TDI scores) did not differ significantly by diabetes duration, age, sex, BMI, lipid profiles, or insulin therapy method. However, a strong negative correlation was observed between long-term mean HbA1c and total TDI scores (r = -0.65, p < 0.001). Logistic regression confirmed that elevated mean HbA1c (> 7.0%) was a significant independent predictor of olfactory impairment, increasing the risk of hyposmia 3.7-fold (OR = 3.726, p = 0.018). CONCLUSIONS: Poor long-term glycemic control significantly impairs olfactory function in adolescents with Type 1 diabetes. This is demonstrated by the marked reduction in olfactory scores among adolescents with high mean HbA1c. Consequently, future research may validate olfactory testing as an effective, early biomarker for diabetic complications. CI - Copyright (c) 2026 Grzegorz Sobek et al. Journal of Diabetes Research published by John Wiley & Sons Ltd. FAU - Sobek, Grzegorz AU - Sobek G AUID- ORCID: 0000-0003-2504-0562 AD - Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, Rzeszow, Poland, ur.edu.pl. AD - University Center for Research and Development in Health Sciences, Rzeszow, Poland. FAU - Jagielski, Pawel AU - Jagielski P AUID- ORCID: 0000-0001-7583-8965 AD - Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland, cm-uj.krakow.pl. FAU - Mazur, Artur AU - Mazur A AUID- ORCID: 0000-0001-5393-3515 AD - Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland. LA - eng PT - Journal Article PL - United States TA - J Diabetes Res JT - Journal of diabetes research JID - 101605237 RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/blood/complications/physiopathology/drug therapy MH - Adolescent MH - Male MH - Female MH - *Glycemic Control MH - Glycated Hemoglobin/metabolism/analysis MH - Child MH - *Olfaction Disorders/etiology/physiopathology/diagnosis MH - *Blood Glucose/metabolism MH - *Smell/physiology MH - *Anosmia/etiology/physiopathology/diagnosis MH - Time Factors MH - Quality of Life PMC - PMC13575325 OTO - NOTNLM OT - Type 1 diabetes OT - adolescents OT - glycated hemoglobin OT - olfactory function COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/09/14 CRDT- 2026/09/15 03:31 PHST- 2026/08/24 00:00 [revised] PHST- 2026/05/29 00:00 [received] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:31 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - JDR8415282 [pii] AID - 10.1155/jdr/8415282 [doi] PST - ppublish SO - J Diabetes Res. 2026;2026(1):e8415282. doi: 10.1155/jdr/8415282. PMID- 42740054 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 17 DP - 2026 Aug 27 TI - Activation Duty Cycle and Regional Muscle Co-Activation Across GMFCS Levels in Ambulatory Children with Spastic Cerebral Palsy: An Exploratory Surface EMG Study. LID - 10.3390/s26175434 [doi] LID - 5434 AB - During self-selected overground walking, we examined participant-level surface electromyography (sEMG) descriptors associated with Gross Motor Function Classification System (GMFCS) levels I-III in 38 ambulatory children with spastic cerebral palsy. Eight-muscle sEMG was summarized using a design-locked pool of 16 peak-normalized envelope and exploratory synergy features. Higher GMFCS level was associated most consistently with longer activation duty cycle, stronger distal and proximal peak-normalized co-activation, and greater inter-muscle spatial entropy. Directions were retained across sensitivity analyses. For secondary within-cohort discrimination, the 16-feature pool yielded a quadratic weighted kappa (QWK) of 0.837+/-0.046 across 50 repeated participant-level nested cross-validation evaluations. Repeating correlation reduction and four-feature selection inside every outer-training fold yielded QWK 0.849+/-0.029. Both estimates reuse the 38 children and describe resampling performance, not independent-population generalizability. The core-four specification was post hoc. In an open supplementary workbook containing 195 unique participant IDs, directional concordance was strongest for activation duty cycle and distal co-activation, but direct transfer of the internally fitted 16-feature and core-four models was poor (QWK 0.210 and 0.077). Without healthy controls or measured walking speed and stride length, these cross-sectional results identify descriptors associated with ambulatory GMFCS level, not cerebral-palsy-specific biomarkers or evidence of clinical predictive utility. FAU - Huang, Peng AU - Huang P AUID- ORCID: 0009-0000-6053-0626 AD - School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408, China. FAU - Zhang, Zhen AU - Zhang Z AUID- ORCID: 0000-0002-2014-5747 AD - School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408, China. FAU - Tong, Yonggang AU - Tong Y AUID- ORCID: 0000-0002-7516-8313 AD - School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408, China. FAU - Sun, Yingfei AU - Sun Y AUID- ORCID: 0000-0003-0615-2569 AD - School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408, China. LA - eng GR - 61431017/National Natural Science Foundation of China/ PT - Journal Article DEP - 20260827 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - *Electromyography/methods MH - Child MH - Female MH - Male MH - *Muscle, Skeletal/physiopathology MH - Walking/physiology MH - Adolescent PMC - PMC13568141 OTO - NOTNLM OT - GMFCS OT - activation duty cycle OT - cerebral palsy OT - feature association OT - interpretable machine learning OT - muscle co-activation OT - surface electromyography COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:25 PHST- 2026/07/29 00:00 [received] PHST- 2026/08/26 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:25 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - s26175434 [pii] AID - sensors-26-05434 [pii] AID - 10.3390/s26175434 [doi] PST - epublish SO - Sensors (Basel). 2026 Aug 27;26(17):5434. doi: 10.3390/s26175434. PMID- 42739246 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260916 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 17 DP - 2026 Sep 1 TI - Comparison of Ultrasound and Scintigraphy in Gastric Emptying: A Comprehensive Review. LID - 10.3390/diagnostics16172816 [doi] LID - 2816 AB - Gastric emptying is the process by which gastric contents are transferred from the stomach to the small intestine for further digestion and nutrient absorption. It is the result of multiple gastrointestinal mechanisms and is essential for understanding the kinetics of digestion in humans. Delayed gastric emptying is clinically relevant as it is commonly observed in conditions such as gastroparesis and functional dyspepsia. A wide range of diagnostic modalities are available to assess gastric emptying, including scintigraphy, ultrasonography, magnetic resonance imaging, gastric aspiration, and stable isotope breath tests. Scintigraphy is widely regarded as the 'gold standard' technique, as it enables a direct quantitative assessment of gastric emptying following ingestion of a radiolabeled meal(s). Scintigraphy is non-invasive, reproducible, widely available, and well tolerated; however, it lacks standardized protocols, is time-consuming, costly, and necessitates exposure to ionizing radiation. Although the radiation dose is low, cumulative exposure remains a concern, particularly in pediatric and pregnant populations. In contrast, ultrasonography is safe, non-invasive, portable, inexpensive, and free from radiation exposure. Nevertheless, the application of ultrasound is limited by operator dependency and the need for technical expertise, and image quality may be affected by factors such as obesity and intraluminal gas. Furthermore, there is substantial methodological variability across studies, and its use in assessing gastric emptying of semisolid and solid meals is less well established. 3D ultrasonography, in particular, shows promise as a safe, non-invasive method for assessing gastric emptying. Further studies are required to promote the consistent application of established scintigraphic gastric emptying protocols across centers and to validate 3D ultrasound, particularly with solid meals, to potentially enhance its role as an alternative to scintigraphy. This article represents a comprehensive review based on a structured literature search with the primary aim of comparing ultrasonographic and scintigraphic measurements of gastric emptying, including the advantages and disadvantages of both methods. FAU - Lein, Emilie AU - Lein E AD - Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway. FAU - Jones, Karen L AU - Jones KL AUID- ORCID: 0000-0002-1155-5816 AD - School of Medicine, Adelaide University, Adelaide 5005, Australia. AD - School of Allied Health and Human Performance, Adelaide University, Adelaide 5005, Australia. AD - Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide 5000, Australia. FAU - Gilja, Odd Helge AU - Gilja OH AUID- ORCID: 0000-0002-0436-0383 AD - Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway. AD - National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. LA - eng PT - Journal Article PT - Review DEP - 20260901 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13565500 OTO - NOTNLM OT - gastric emptying OT - gastric function OT - scintigraphy OT - stomach OT - ultrasound COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/01 CRDT- 2026/09/15 03:24 PHST- 2026/06/11 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - diagnostics16172816 [pii] AID - diagnostics-16-02816 [pii] AID - 10.3390/diagnostics16172816 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Sep 1;16(17):2816. doi: 10.3390/diagnostics16172816. PMID- 42739090 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 6 TI - Maternal Consumption of Fruits, Vegetables and Fruit Juices in Relation to Offspring Weight at 4 Years. LID - 10.3390/nu18172918 [doi] LID - 2918 AB - Background/Objectives: Maternal diet plays a crucial role in fetal development and may influence offspring weight development. Although fruits and vegetables provide nutritional and metabolic benefits during pregnancy, evidence regarding their specific role on childhood overweight/obesity remains limited. This study aimed to examine the association between maternal intake of fruits, vegetables, and fruit juices during pregnancy and the risk of overweight/obesity in children at 4 years of age. Methods: We analyzed 252 mother-child pairs from the Mediterranean ECLIPSES cohort in a prospective observational study. Maternal dietary intake was assessed at 12, 24 and 36 weeks of gestation using a semiquantitative food frequency questionnaire previously validated in a Spanish population. Childhood overweight/obesity was defined as a BMI z-score above the 85th percentile for age and sex at age 4. Multivariable-adjusted logistic regression models estimated ORs and 95% CIs. Results: Higher maternal consumption of fruits and vegetables was inversely associated with overweight/obesity in children (OR: 0.31 [0.13-0.74]). No associations were observed for total or natural fruit juice, whereas higher consumption of commercial fruit juice was associated with increased odds of overweight/obesity (OR: 2.48 [1.06-5.78]). Conclusions: Higher maternal combined consumption of fruits and vegetables during pregnancy was associated with lower odds of overweight or obesity in offspring at 4 years of age, whereas the opposite association was observed for commercial, but not natural, fruit juice. These associations may involve both prenatal biological and postnatal behavioral and family dietary pathways; however, the commercial fruit juice finding should be considered exploratory and requires confirmation in larger prospective studies. FAU - Riggioni-Saborio, Lucia AU - Riggioni-Saborio L AUID- ORCID: 0009-0004-9880-7159 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. FAU - Jardi, Cristina AU - Jardi C AUID- ORCID: 0000-0002-7946-1488 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. FAU - Cruz-Rodriguez, Josue AU - Cruz-Rodriguez J AUID- ORCID: 0000-0001-7145-5836 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. FAU - Arija, Victoria AU - Arija V AUID- ORCID: 0000-0002-1758-0975 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. AD - Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut D'Investigacio en Atencio Primaria IDIAP Jordi Gol, 08007 Barcelona, Spain. LA - eng GR - PI12/02777/Institute of Health Carlos III/ GR - PI17/01754/Instituto de Salud Carlos III/ GR - European Union/ PT - Journal Article PT - Observational Study DEP - 20260906 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Fruit MH - *Vegetables MH - Female MH - *Fruit and Vegetable Juices MH - Pregnancy MH - Child, Preschool MH - Prospective Studies MH - *Maternal Nutritional Physiological Phenomena MH - Spain/epidemiology MH - *Pediatric Obesity/epidemiology/prevention & control/etiology MH - Male MH - Adult MH - Developmental Origins of Health and Disease MH - *Diet PMC - PMC13567673 OTO - NOTNLM OT - childhood obesity OT - fruit consumption OT - fruit juice consumption OT - maternal nutrition OT - pregnancy OT - vegetable consumption COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/09/06 CRDT- 2026/09/15 03:24 PHST- 2026/07/20 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/06 00:00 [pmc-release] AID - nu18172918 [pii] AID - nutrients-18-02918 [pii] AID - 10.3390/nu18172918 [doi] PST - epublish SO - Nutrients. 2026 Sep 6;18(17):2918. doi: 10.3390/nu18172918. PMID- 42739088 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 5 TI - Associations of Diabetes-Related Distress, Disordered-Eating Risk, and Self-Perceived Health with Glycemic Outcomes in Adolescents with Type 1 Diabetes: An Exploratory Cross-Sectional Study. LID - 10.3390/nu18172916 [doi] LID - 2916 AB - Background/Objectives: Adolescents with type 1 diabetes mellitus (T1DM) are particularly vulnerable to psychological distress, disordered-eating (DE) risk and negative self-perceived health status (SPHS), which may compromise metabolic control and self-care. Although these factors have been studied individually, the usefulness of brief and clinically feasible screening tools to detect these dimensions remains underexplored. This study aimed to: (1) examine associations between distress, DE risk and SPHS; (2) explore their relationships with glycemic control, clinical profile and self-care; and (3) assess the influence of age and diabetes duration on these outcomes. Methods: A cross-sectional study was conducted in 37 adolescents with T1DM in Spain. Sociodemographic, anthropometric and clinical variables were obtained from medical records. Distress, DE risk and self-care were assessed using validated questionnaires, while SPHS was measured using single-item question. Pearson and Spearman correlations were performed. Results: Distress was present in 48.6% of participants and DE risk in 29.7%, while 67.6% reported positive SPHS. Distress correlated with higher HbA1c and lower TIR. DE risk correlated with BMI. Lower SPHS was associated with higher HbA1c. Age and diabetes duration were associated with greater glycemic variability, and diabetes duration also correlated with higher glucose and TyG-based insulin resistance indexes. No significant associations were found for self-care behaviors. Conclusions: Distress, DE risk and SPHS, assessed through feasible screening tools, showed meaningful associations with metabolic outcomes in adolescents with T1DM. Integrating brief psychological screening tools into routine care may facilitate early identification of psychological vulnerability profiles in this population during routine practice. FAU - Garcia-Poblet, Marta AU - Garcia-Poblet M AUID- ORCID: 0000-0001-7110-6222 AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. AD - Research Group on Applied Dietetics, Nutrition and Body Composition (DANuC), University of Alicante, 03692 Alicante, Spain. FAU - Sospedra, Isabel AU - Sospedra I AUID- ORCID: 0000-0002-8513-8986 AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. AD - Research Group on Applied Dietetics, Nutrition and Body Composition (DANuC), University of Alicante, 03692 Alicante, Spain. FAU - Formilan, Brisa Florencia AU - Formilan BF AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. FAU - Soler-Climent, Esther AU - Soler-Climent E AUID- ORCID: 0000-0002-8543-4865 AD - Research and Innovation Area, Health Department of General Hospital of Elche, 03203 Elche, Alicante, Spain. AD - Traumatology and Neurosurgery Service, General Hospital of Elche, 03203 Elche, Alicante, Spain. FAU - Alberola-Chazarra, Manuel Antonio AU - Alberola-Chazarra MA AD - Pediatrics Unit, General Hospital of Elche, 03203 Elche, Alicante, Spain. FAU - Martinez-Sanz, Jose Miguel AU - Martinez-Sanz JM AUID- ORCID: 0000-0001-9054-3858 AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. AD - Research Group on Applied Dietetics, Nutrition and Body Composition (DANuC), University of Alicante, 03692 Alicante, Spain. LA - eng PT - Journal Article DEP - 20260905 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/blood/complications MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - Male MH - *Feeding and Eating Disorders/psychology/epidemiology MH - *Psychological Distress MH - *Self Concept MH - Self Care MH - Blood Glucose/metabolism MH - *Stress, Psychological MH - Risk Factors MH - Glycated Hemoglobin MH - Glycemic Control/psychology MH - Health Status MH - Spain MH - Surveys and Questionnaires PMC - PMC13567549 OTO - NOTNLM OT - adolescents OT - eating disorders OT - metabolic control OT - psychological distress OT - self-perceived health OT - type 1 diabetes mellitus COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/09/05 CRDT- 2026/09/15 03:24 PHST- 2026/07/04 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - nu18172916 [pii] AID - nutrients-18-02916 [pii] AID - 10.3390/nu18172916 [doi] PST - epublish SO - Nutrients. 2026 Sep 5;18(17):2916. doi: 10.3390/nu18172916. PMID- 42739061 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 3 TI - Food Allergies and Eating Disorders: An Exploration of Screening Prevalence and Associated Factors Among Adults. LID - 10.3390/nu18172890 [doi] LID - 2890 AB - Background/Objectives: Food allergy (FA) affects up to 10% of adults and requires ongoing dietary vigilance that may increase vulnerability to eating disorders (EDs), yet evidence in adults remains limited. This study compared ED screening and history between adults with and without food allergy (FA), and explored factors associated with positive screening among those with FA. Methods: This cross-sectional study recruited 371 adults (134 with FA, 237 without) via an online survey. Positive screening required meeting thresholds on both the Eating Attitudes Test-8 (EAT-8) and the Sick, Control, One, Fat, Food (SCOFF); ED history and treatment were assessed via self-report. Group differences were examined using chi-square tests and, for the primary comparison, age- and sex-adjusted logistic regression. Among those with FA, correlations identified candidate predictors of positive screening, which were entered into a further logistic regression. Results: FA status was not associated with positive screening for an ED (37.3% vs. 37.1%; p = 0.972), including after adjusting for age and sex. FA was significantly associated with a greater lifetime history of EDs (36.4% vs. 20.7%; p = 0.001) and ED treatment (17.9% vs. 10.1%; p = 0.032). Among those with FA, positive screening was independently predicted by ED history and shorter allergy duration in a multivariable model (Nagelkerke R(2) = 0.14); however, allergy duration and age were highly correlated, so this effect could not be shown to be independent of age. Conclusions: FA alone was not statistically associated with current positive screening but was linked to lifetime history and treatment, suggesting that this relationship may be more evident earlier in the FA experience. ED history and shorter allergy duration were associated with positive screening among those with FA, though the duration effect may partly reflect age; sex was linked to screening only at the bivariate level, given too few male positive cases to model. Findings are preliminary, given the FA-unvalidated screening tools used, warranting longitudinal validated research. FAU - Hine, Jessica AU - Hine J AD - School of Psychology, University of Surrey, Guildford GU2 7XH, UK. AD - Surrey & Borders Partnership NHS Trust, Leatherhead KT22 7AD, UK. FAU - Andresen, Kirsty AU - Andresen K AUID- ORCID: 0000-0002-5483-6482 AD - Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK. FAU - Satherley, Rose-Marie AU - Satherley RM AUID- ORCID: 0000-0002-7535-2292 AD - School of Psychology, University of Surrey, Guildford GU2 7XH, UK. FAU - Jones, Christina J AU - Jones CJ AUID- ORCID: 0000-0003-3672-6631 AD - School of Psychology, University of Surrey, Guildford GU2 7XH, UK. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - *Food Hypersensitivity/epidemiology/diagnosis MH - Male MH - Adult MH - Cross-Sectional Studies MH - *Feeding and Eating Disorders/epidemiology/diagnosis MH - Prevalence MH - Middle Aged MH - Young Adult MH - Logistic Models MH - Risk Factors MH - Adolescent MH - Mass Screening MH - Surveys and Questionnaires PMC - PMC13567571 OTO - NOTNLM OT - adults OT - disordered eating OT - eating disorders OT - food allergy OT - prevalence OT - screening COIS- R.-M.S.: Research funding from the National Institute for Health and Care Research (NIHR) and Coeliac UK. Honoraria from Dr Schar and My NutriWeb. C.J.J.: Research funding from the NIHR, Innovate UK, Food Standards Agency, Aimmune, the National Peanut Board, and Novartis. Honoraria from the NIHR, Nutricia, Mead Johnson, DBV Technologies, Allergy UK, The Milk Allergy Dietitian, and Siemens Healthineers. Member of the Allergy UK Health Advisory Board, British Society for Allergy & Clinical Immunology Psychology Special Interest Group (SIG), and the British Psychological Society Paediatric Allergy SIG. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/03 CRDT- 2026/09/15 03:24 PHST- 2026/07/28 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - nu18172890 [pii] AID - nutrients-18-02890 [pii] AID - 10.3390/nu18172890 [doi] PST - epublish SO - Nutrients. 2026 Sep 3;18(17):2890. doi: 10.3390/nu18172890. PMID- 42739059 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 3 TI - Assessment of Nutritional Risk Representations in Publicly Available Data in Saudi Arabia: A Triangulated Scoping Study. LID - 10.3390/nu18172888 [doi] LID - 2888 AB - Background: Saudi Arabia maintains official statistics on its food security, in addition to conducting surveys on health parameters and performing national health assessments. Also, several academic papers on dietary patterns are published every year. Many published documents analyze data on food availability, self-reported eating habits, and biomarker-based health risks. However, individually, they represent distinct aspects of nutrition. Hence, this study was undertaken to examine publicly accessible nutrition-related evidence in Saudi Arabia and assess whether existing public food and nutrition datasets consistently align with the biological indicators of nutritional risk. Methods: Searches were conducted using defined criteria in publicly available Saudi and international sources published or updated between 2005 and 2025. These were identified through official reports, global food databases, WHO-aligned surveys, and peer-reviewed articles, with searches conducted and updated during June-July 2026. Sources were classified by representativeness, recency, measurement validity, accessibility, and analytical role. The primary outcome was the completeness and interpretability of public evidence streams rather than a pooled prevalence estimate. Results: SHIS 2013 remains the top public national dietary intake dataset, which shows that only 5.2% and 7.5% of people met their fruit and vegetable intake recommendations, respectively. GASTAT Health Determinants Statistics 2024 indicated that only 10.2% of people aged 15 years and above ate five or more portions of fruits and vegetables daily, yet GASTAT Food Security Statistics 2024 indicated significant per capita availability of rice, milk, poultry, eggs, red meat, onions, tomatoes, and dates. High levels of biological risk were evident in WHS 2019 biomarkers; for example, 42.6% of people had hypercholesterolemia and 50% had low hemoglobin according to the WHS 2019 indicator definition. Recent studies provided additional data on beverages, sugars, dietary habits of adolescents, and diet quality but lacked national food-wide intake data. Conclusions: Public Saudi nutrition data provide complementary but non-equivalent information; indicators show low dietary adequacy and high biomarker-defined risk, supporting the need for integrated individual-level nutrition surveillance. In the future, Saudi national nutrition surveillance must focus on individual-level intake data and biomarker-based measurements. FAU - Alagal, Reham I AU - Alagal RI AUID- ORCID: 0000-0002-8515-1574 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Saudi Arabia/epidemiology MH - Humans MH - *Diet/statistics & numerical data MH - *Nutritional Status MH - Vegetables MH - Fruit MH - Feeding Behavior MH - Risk Assessment MH - Adolescent MH - Biomarkers MH - Female PMC - PMC13567205 OTO - NOTNLM OT - Saudi Arabia OT - biomarkers OT - dietary consumption OT - food availability OT - food balance sheets OT - fruit and vegetable consumption OT - hypercholesterolaemia OT - low haemoglobin OT - nutrition surveillance COIS- The author declares no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/03 CRDT- 2026/09/15 03:24 PHST- 2026/07/05 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - nu18172888 [pii] AID - nutrients-18-02888 [pii] AID - 10.3390/nu18172888 [doi] PST - epublish SO - Nutrients. 2026 Sep 3;18(17):2888. doi: 10.3390/nu18172888. PMID- 42739044 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 2 TI - Urban-Rural Disparities in School Lunch Food Composition: Evidence from 12.7 Million Dish Records in Taiwan's National School Food Registry. LID - 10.3390/nu18172871 [doi] LID - 2871 AB - Background/Objectives: For many schoolchildren-particularly those in low-resource areas-the school lunch is the most reliable balanced meal of the day, so its composition is a direct determinant of dietary equity. The aim of this study was to quantify urban-rural disparities in school lunch food composition at national scale and to test whether they persist once county socioeconomic structure is controlled. Methods: Using 12,688,008 dish records from 3894 schools across all 22 Taiwanese counties over 24 months (May 2024-April 2026), retrieved from the Ministry of Education's School Food Registry Platform, we constructed four dish-level dietary composition indicators-plant-forward, organic, processed, and whole-grain shares-and analyzed county-month panels (N = 418) using hierarchical regression with weighted least squares and heteroskedasticity-consistent standard errors. Results: The four dimensions followed distinct urban-rural patterns. Plant-forward provision exhibited a stable urban-to-rural decline. Organic and whole-grain provision displayed a suppressor structure: rural disadvantage disappeared-and reversed-once county income was controlled, revealing latent local supply capacity masked by income disparities. Processed-dish use, once income and population density were accounted for, was concentrated in lower-income, more densely populated counties rather than rural ones, indicating an urban concentration pattern rather than a rural deficit. A 2017 traceable-food pilot policy still exhibited a legacy effect on organic procurement seven years after its nationwide rollout. Conclusions: School meal programs thus deliver systematically different dietary environments to children in different places. Narrowing these gaps, rather than raising national averages, should be the core criterion for evaluating school lunch reform, with interventions differentiated across dietary dimensions. FAU - Wang, Hui-Min AU - Wang HM AUID- ORCID: 0000-0002-1774-9881 AD - Department of Bio-Industry Communication and Development, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 106, Taiwan. FAU - Wang, Jiun-Hao AU - Wang JH AUID- ORCID: 0000-0001-7861-0341 AD - Department of Bio-Industry Communication and Development, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 106, Taiwan. FAU - Wu, Kuo-Chen AU - Wu KC AUID- ORCID: 0000-0001-9292-2819 AD - Graduate Institute of Mass Communication, National Taiwan Normal University, 7F, General Building, No. 129-1, Sec. 1, Heping E. Rd., Taipei 106, Taiwan. LA - eng PT - Journal Article DEP - 20260902 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Taiwan MH - *Lunch MH - *Schools/statistics & numerical data MH - *Food Services/statistics & numerical data MH - *Urban Population/statistics & numerical data MH - *Rural Population/statistics & numerical data MH - Child MH - Registries MH - Diet/statistics & numerical data MH - Socioeconomic Disparities in Health MH - Socioeconomic Factors PMC - PMC13567730 OTO - NOTNLM OT - Taiwan OT - child nutrition OT - dietary patterns OT - public food procurement OT - school meals OT - ultra-processed food OT - urban-rural disparities OT - whole-grains COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/02 CRDT- 2026/09/15 03:24 PHST- 2026/07/19 00:00 [received] PHST- 2026/08/17 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - nu18172871 [pii] AID - nutrients-18-02871 [pii] AID - 10.3390/nu18172871 [doi] PST - epublish SO - Nutrients. 2026 Sep 2;18(17):2871. doi: 10.3390/nu18172871. PMID- 42739031 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 1 TI - A Comprehensive Study of Dietary and Lifestyle Correlates of Erythrocyte Membrane Fatty Acids and Oxidative Stress and Their Association with Maternal and Neonatal Outcomes. LID - 10.3390/nu18172859 [doi] LID - 2859 AB - Background: Erythrocyte fatty acid (FA) and oxidative stress levels are influenced by a range of factors. The aim of this study was to evaluate erythrocyte FA profiles and oxidative stress markers and their relationships with each other, nutrition, lifestyle, gestational age, and pregnancy outcomes in pregnant Latvian women. Methods: A total of 74 pregnant and postpartum women were cross-sectionally examined. Dietary intake was assessed using a validated food frequency questionnaire; erythrocyte FA composition was analyzed using gas chromatography with a flame ionization detector; and oxidative status was assessed based on Ferric Reducing Antioxidant Power (FRAP) assays, glutathione peroxidase (GPx) activity, and selenoprotein P (SEPP1) and malondialdehyde (MDA) levels. Results: Dietary fats constituted 42.0% of the total caloric intake. Saturated fatty acids (SFAs) predominated in erythrocytes (55.7%), with the highest concentration observed for 16:0. Although multiple significant correlations between dietary factors and laboratory parameters were identified, none remained significant after correction for multiple comparisons. Erythrocyte 18:3, n-3 was significantly associated with FRAP (p < 0.05). Gestational complications and age did not affect biochemical parameters (p > 0.05), though gestational age correlated with MDA (r = 0.377, p < 0.05) and pre-pregnancy body mass index (BMI) with MUFAs (r = 0.373, p < 0.01). The FA composition differed depending on smoking status and alcohol consumption. Conclusions: Given the exploratory nature of this study, findings should be interpreted with appropriate caution. Several associations retained statistical significance following correction for multiple comparisons, namely between erythrocyte 18:3, n-3 and FRAP, alcohol consumption and smoking with erythrocyte fatty acid profiles, maternal age and plasma MDA concentrations, and pre-gestational BMI and MUFA levels. The remaining associations did not withstand correction and should therefore be regarded as hypothesis-generating, warranting confirmation in larger, adequately powered, confirmatory studies. FAU - Nikolajeva, Ksenija AU - Nikolajeva K AD - Riga East Clinical University Hospital, 2 Hipokrata Street, LV-1038 Riga, Latvia. AD - Doctoral Department, Faculty of Medicine, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, Latvia. AD - Department of Rehabilitation, Riga Stradins University, 26a Anninmuizas Boulevard, LV-1067 Riga, Latvia. FAU - Lece, Anna AU - Lece A AUID- ORCID: 0000-0002-0970-2127 AD - Institute of Occupational Safety and Environmental Health, Riga Stradins University, LV-1067 Riga, Latvia. FAU - Skesters, Andrejs AU - Skesters A AUID- ORCID: 0000-0003-3726-8724 AD - Institute of Occupational Safety and Environmental Health, Riga Stradins University, LV-1067 Riga, Latvia. FAU - Cauce, Vinita AU - Cauce V AD - Statistics Unit, Riga Stradins University, 14 Balozu Street, LV-1048 Riga, Latvia. FAU - Zacs, Dzintars AU - Zacs D AD - Scientific Institute of Food Safety, Animal Health, and Environment, Lejupes Street 3, LV-1076 Riga, Latvia. FAU - Meija, Laila AU - Meija L AUID- ORCID: 0000-0002-8205-0639 AD - Riga East Clinical University Hospital, 2 Hipokrata Street, LV-1038 Riga, Latvia. AD - Department of Rehabilitation, Riga Stradins University, 26a Anninmuizas Boulevard, LV-1067 Riga, Latvia. LA - eng GR - Izp-2019/1-0335/Latvian Council of Science/ GR - 6-DN-20/4/2026/Riga Stradins University/ PT - Journal Article DEP - 20260901 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Fatty Acids) RN - 0 (Biomarkers) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Female MH - *Oxidative Stress MH - Pregnancy MH - *Fatty Acids/blood MH - Adult MH - *Life Style MH - *Erythrocyte Membrane/metabolism/chemistry MH - Cross-Sectional Studies MH - *Pregnancy Outcome MH - *Diet MH - Biomarkers/blood MH - Gestational Age MH - Infant, Newborn MH - Latvia MH - Nutritional Status MH - Dietary Fats PMC - PMC13567114 OTO - NOTNLM OT - fatty acids OT - nutrition OT - oxidative stress OT - pregnancy COIS- The authors declare no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:38 PMCR- 2026/09/01 CRDT- 2026/09/15 03:23 PHST- 2026/05/25 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 11:38 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - nu18172859 [pii] AID - nutrients-18-02859 [pii] AID - 10.3390/nu18172859 [doi] PST - epublish SO - Nutrients. 2026 Sep 1;18(17):2859. doi: 10.3390/nu18172859. PMID- 42739020 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 31 TI - Trends and Contextual Factors Related to Obesity-Related Legislation in the Republic of Korea (2006-2024). LID - 10.3390/nu18172848 [doi] LID - 2848 AB - OBJECTIVES: The objective of this paper is to analyse trends in obesity-related legislation in the Republic of Korea (2006-2024) and examine political, institutional, and ideational factors observed in relation to legislative outcomes. METHODS: A retrospective policy analysis of 53 obesity-related bills identified through systematic searches of the National Assembly Legislative Information System and independently coded by two researchers. Quantitative trends were examined by policy domain and instrument type, and qualitative analysis applied Kingdon's Multiple Streams Framework, the Ideas-Interests-Institutions (3I) model, and Policy Instrument Theory. RESULTS: Legislative attention increased unevenly across the study period. Sixteen bills (30.2%) achieved a favorable legislative outcome, comprising direct passage or incorporation into an enacted committee alternative. Regulatory instruments dominated, followed by educational and institutional tools; fiscal measures were rare. Legislative activity clustered in 2013 and 2017-2019, while later proposals increasingly addressed school, digital, and post-pandemic concerns. CONCLUSIONS: Korea's experience shows both progress and fragmentation in obesity governance. Child-focused framing and institutional feasibility were recurrent features among enacted measures, whereas fiscal and structural proposals were less frequently enacted. The findings highlight the importance of considering regulatory, educational, and fiscal approaches within a comprehensive intersectoral policy framework. FAU - Lee, Yuri AU - Lee Y AUID- ORCID: 0000-0002-2780-7678 AD - Department of Health and Medical Information, Myongji College, Seoul 03656, Republic of Korea. AD - Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London WC1H 9SH, UK. FAU - Shin, Hyun-Young AU - Shin HY AD - Department of Family Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea. LA - eng PT - Journal Article DEP - 20260831 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Republic of Korea/epidemiology MH - Humans MH - *Obesity/prevention & control/epidemiology MH - *Health Policy/legislation & jurisprudence/trends MH - Retrospective Studies MH - Policy Making PMC - PMC13567622 OTO - NOTNLM OT - Republic of Korea OT - child nutrition OT - multiple streams framework OT - obesity legislation OT - public health policy COIS- The authors declare no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/31 CRDT- 2026/09/15 03:23 PHST- 2026/07/14 00:00 [received] PHST- 2026/08/21 00:00 [revised] PHST- 2026/08/22 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - nu18172848 [pii] AID - nutrients-18-02848 [pii] AID - 10.3390/nu18172848 [doi] PST - epublish SO - Nutrients. 2026 Aug 31;18(17):2848. doi: 10.3390/nu18172848. PMID- 42738991 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 28 TI - Dairy Product Consumption Patterns and Associated Sociodemographic and Lifestyle Factors Among Adults from Selected Peruvian Cities. LID - 10.3390/nu18172819 [doi] LID - 2819 AB - Background: Dairy products provide protein, calcium, and other essential nutrients, but intake may vary across sociodemographic and lifestyle groups. Objective: To characterize dairy consumption patterns and identify factors associated with consuming >/=3 dairy servings/day among adults recruited from selected Peruvian cities. Methods: A cross-sectional study was conducted from April to June 2026. Of the 1619 eligible participants, 203 (12.5%) reported no dairy consumption and were analyzed separately for reasons for non-consumption; the final analytical sample included 1265 dairy consumers. Dairy intake was assessed using a culturally adapted questionnaire with content validity evaluated by expert judgment. Descriptive analyses, bivariate tests, and multivariable logistic regression were performed. Results: Mean age was 33.0 +/- 13.0 years, and 61.2% were women. The most commonly consumed products were cheese (90.9%), yogurt (85.4%), whole milk (71.2%), and quesillo or fresh cheese (60.8%). Overall, 16.3% consumed >/=3 dairy servings/day. Participants recruited from cities in the Highlands (aOR = 0.54; 95% CI: 0.37-0.79) and Amazon (aOR = 0.59; 95% CI: 0.40-0.87) had lower odds of reaching this threshold than those from the Coast. Middle socioeconomic status was associated with lower odds (aOR = 0.48; 95% CI: 0.34-0.67), whereas physical activity >/=3 times/week was associated with higher odds (aOR = 1.53; 95% CI: 1.09-2.14). Perceived lactose intolerance was the most frequently reported reason for non-consumption (46.8%). Conclusions: Consumption of >/=3 dairy servings/day was uncommon. Socioeconomic differences were the most consistent correlate, while geographic and physical activity associations warrant cautious interpretation. FAU - Paz-Olivas, Youmi AU - Paz-Olivas Y AD - Area de Investigacion, Instituto de Nutricion y Seguridad Alimentaria, Lima 15026, Peru. AD - Escuela de Nutricion y Dietetica, Universidad Femenina Sagrado Corazon (UNIFE), La Molina, Lima 15023, Peru. FAU - Duran-Aguero, Samuel AU - Duran-Aguero S AUID- ORCID: 0000-0002-0548-3676 AD - Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Providencia 7500000, Chile. FAU - Saintila, Jacksaint AU - Saintila J AUID- ORCID: 0000-0002-7340-7974 AD - Research Group on Nutritional Psychology and Public Health, Universidad Peruana Union, Lima 15464, Peru. LA - eng PT - Journal Article DEP - 20260828 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - Peru MH - *Dairy Products/statistics & numerical data MH - Cross-Sectional Studies MH - Male MH - *Life Style MH - Middle Aged MH - *Sociodemographic Factors MH - Young Adult MH - Socioeconomic Factors MH - Cities MH - *Diet/statistics & numerical data MH - *Feeding Behavior MH - Adolescent PMC - PMC13567231 OTO - NOTNLM OT - Peru OT - adults OT - dairy products OT - dietary intake OT - food consumption OT - lactose intolerance OT - socioeconomic status COIS- Y.P.-O. is employed as Nutrition Manager at Grupo Gloria, a company operating in the dairy sector. Grupo Gloria had no role in the funding of the study; study design; data collection, analysis, or interpretation; preparation or writing of the manuscript; or the decision to submit the manuscript for publication. S.D.-A. and J.S. declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/28 CRDT- 2026/09/15 03:23 PHST- 2026/08/03 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/28 00:00 [pmc-release] AID - nu18172819 [pii] AID - nutrients-18-02819 [pii] AID - 10.3390/nu18172819 [doi] PST - epublish SO - Nutrients. 2026 Aug 28;18(17):2819. doi: 10.3390/nu18172819. PMID- 42738983 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 27 TI - Development and Feasibility Study of Sustainable ePlate: A Web-Based Serious Game for Multidimensional Sustainable Healthy Diet Interventions in Schools. LID - 10.3390/nu18172812 [doi] LID - 2812 AB - BACKGROUND: School-based sustainable and healthy diet (SHD) interventions often inadequately capture the multidimensional nature of sustainability, with socioeconomic and cultural dimensions frequently underrepresented. While digital interventions can facilitate the integration of multiple SHD components, maintaining user engagement remains a persistent challenge that can compromise intervention effectiveness. Digital serious games represent a promising intervention strategy that can address both limitations by delivering multidimensional SHD content through interactive and engaging learning, while enabling real-time behavioral monitoring. OBJECTIVES: To assess the feasibility, as well as the acceptability and user experience of "Sustainable ePlate", a web-based serious game for multidimensional SHD educational interventions in schools, during school-based sessions. METHODS: Sustainable ePlate integrates food-level sustainability indicators into a scaffolded nine-challenge serious game. Challenges are presented through the healthy eating plate structure, while addressing eight food-level sustainability indicators transformed into 1-5 ordinal game scores. A database of 138 food items was developed from publicly available LCA and TCA databases. The game design draws on established learning theories implemented through progressive challenge sequencing, tiered feedback, and social features. Feasibility was assessed in guided school sessions in Northern Greece using the eGameFlow questionnaire and system in-app metrics. RESULTS: The assessment sample comprised n = 59 students from two secondary schools, of whom n = 57 completed the eGameFlow questionnaire. Mean overall enjoyment was 82.54 +/- 16.33%. Mean session duration was 22.39 +/- 12.68 min. Across all sessions, 6003 food selections were recorded, with 5179 correct and 824 incorrect placements, corresponding to an 86.27% placement accuracy rate. In-app metrics indicated strong technical feasibility, with all sessions completing the full game sequence. Behavioral metrics demonstrated active interaction, characterized by placement interval duration, hesitation times, and high placement accuracy. CONCLUSIONS: Sustainable ePlate demonstrated feasibility and a positive user experience as a school-based serious game for multidimensional SHD education, and as a research platform for capturing in-app behavioral metrics. Further studies are required to assess its educational effectiveness in improving knowledge, attitudes, and practices related to sustainable healthy diets through pre-post design interventions. FAU - Patra, Elena AU - Patra E AUID- ORCID: 0000-0002-8615-1541 AD - Nutrition Information Systems Laboratory (NISLAB), Department of Nutritional Sciences and Dietetics, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Hassapidou, Maria AU - Hassapidou M AD - Nutrition Information Systems Laboratory (NISLAB), Department of Nutritional Sciences and Dietetics, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Androutsos, Odysseas AU - Androutsos O AUID- ORCID: 0000-0002-2849-1994 AD - Laboratory of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, School of Physical Education, Sports Science and Dietetics, University of Thessaly, 42132 Trikala, Greece. FAU - Diou, Christos AU - Diou C AUID- ORCID: 0000-0002-2461-1928 AD - Department of Informatics and Telematics, School of Digital Technology, Harokopio University of Athens, 17778 Athens, Greece. FAU - Pagkalos, Ioannis AU - Pagkalos I AUID- ORCID: 0000-0002-1538-4663 AD - Nutrition Information Systems Laboratory (NISLAB), Department of Nutritional Sciences and Dietetics, International Hellenic University, 57400 Thessaloniki, Greece. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Feasibility Studies MH - *Diet, Healthy/methods MH - *Video Games MH - Schools MH - Female MH - *Health Promotion/methods MH - Male MH - *Internet MH - Child MH - *School Health Services MH - Adolescent MH - Greece MH - Digital Media PMC - PMC13567481 OTO - NOTNLM OT - behavioral monitoring OT - digital interventions OT - gamification OT - nutrition education OT - school intervention OT - serious game OT - sustainable healthy diet COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:23 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - nu18172812 [pii] AID - nutrients-18-02812 [pii] AID - 10.3390/nu18172812 [doi] PST - epublish SO - Nutrients. 2026 Aug 27;18(17):2812. doi: 10.3390/nu18172812. PMID- 42738982 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 27 TI - Mediterranean Diet Adherence, Nutrition Knowledge and Lifestyle Factors in Physically Active Adults and Athletes: The NUTRI_ACTIVE Study. LID - 10.3390/nu18172810 [doi] LID - 2810 AB - Background/Objectives: Unhealthy diets and poor lifestyle choices can increase athlete's risk of low energy availability (LEA) and its negative consequences. Conversely, optimal nutrition, such as the Mediterranean Diet (MedDiet), promotes health, recovery, and performance. This study evaluates MedDiet adherence among athletes and physically active individuals, exploring its relationship with nutrition knowledge (NK), dietary intake, eating behaviors, and sleep quality. Methods: This single-center observational study evaluated Italian healthy active adults/athletes (18-65 years) categorized into four performance Tiers. Validated questionnaires analyzed MedDiet adherence (MEDI-LITE), NK (GeSNK), eating behaviour (EAT-26 and TOS), sleep quality (PSQI), and physical activity (IPAQ). Dietary intake was estimated via a 7-day food diary. Body composition (skinfolds/BIVA), and resting energy expenditure (indirect calorimetry) were assessed. Results: Analysis included 169 participants (32.3 +/- 11.9 years; 52.7% females; 56.8% Tier 1), practicing 2.0 +/- 0.9 sports with 7.1 +/- 3.7 h/week of training. Mean MEDI-LITE score was 10.6 +/- 2.2 (moderate adherence) across all Tiers and was significantly, positively associated with NK (p = 0.002). Mean EA was 31.3 +/- 8.6 kcal/kg FFM/day; sex-specific cut-offs revealed a substantial proportion of high-tier participants with low/suboptimal EA. Eating disorder risk and orthorexic tendencies were low, sleep quality was generally good; none significantly correlated with MEDI-LITE score. Conclusions: Higher NK was positively associated with MedDiet adherence. However, high-tier athletes showed low or suboptimal EA. Targeted nutrition education must integrate MedDiet principles with sport-specific fueling strategies, optimizing diet quality and energy adequacy. FAU - Fiorini, Simona AU - Fiorini S AUID- ORCID: 0009-0005-2790-0601 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Guglielmetti, Monica AU - Guglielmetti M AUID- ORCID: 0000-0001-6327-9959 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Lopes Neri, Lenycia de Cassya AU - Lopes Neri LC AUID- ORCID: 0000-0002-4162-3664 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Ferraro, Ottavia Eleonora AU - Ferraro OE AUID- ORCID: 0000-0002-4398-4885 AD - Unit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Rondanelli, Mariangela AU - Rondanelli M AUID- ORCID: 0000-0001-8336-4851 AD - Human Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Tagliabue, Anna AU - Tagliabue A AUID- ORCID: 0000-0002-7647-6975 AD - Human Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Ferraris, Cinzia AU - Ferraris C AUID- ORCID: 0000-0002-4148-2136 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. LA - eng GR - Project code PE0000003/Ministry of Universities and Research/ PT - Journal Article PT - Observational Study DEP - 20260827 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Mediterranean MH - Female MH - Male MH - Adult MH - *Athletes/psychology/statistics & numerical data MH - Young Adult MH - Middle Aged MH - *Life Style MH - *Health Knowledge, Attitudes, Practice MH - Adolescent MH - Feeding Behavior MH - *Exercise MH - Aged MH - Italy MH - Surveys and Questionnaires MH - *Patient Compliance MH - Energy Metabolism MH - Energy Intake MH - Body Composition MH - Sleep Quality MH - Nutritional Status PMC - PMC13567227 OTO - NOTNLM OT - athletes OT - energy availability OT - lifestyle OT - mediterranean diet OT - nutrition knowledge OT - sport nutrition COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:23 PHST- 2026/07/21 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - nu18172810 [pii] AID - nutrients-18-02810 [pii] AID - 10.3390/nu18172810 [doi] PST - epublish SO - Nutrients. 2026 Aug 27;18(17):2810. doi: 10.3390/nu18172810. PMID- 42738976 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 27 TI - Examining Demographic Variables Associated with Fruit and Vegetable Intake and Skin Yellowness. LID - 10.3390/nu18172804 [doi] LID - 2804 AB - Background/Objectives: Skin yellowness measured using reflectance spectroscopy can be used as a proxy for 'skin carotenoid' concentration and as a valid estimate of fruit and vegetable intake. However, the association between different ethnic backgrounds, age, sex and self-reported skin colour on skin yellowness is yet to be explored. Methods: This exploratory cross-sectional study used a convenience sample to assess the relationship between skin yellowness (b*), measured using skin reflectance spectroscopy, and fruit and vegetable intakes across different age groups, sex, self-reported Caucasian and Asian ethnicities and self-reported skin colour. Recruited adults were aged >/=18 years who self-reported as Caucasian or of Asian ethnicity (N = 137). Data were collected on skin L*, a*, b* colours using skin reflectance spectroscopy, height, weight, body composition, waist circumference, demographic variables (e.g., age, sex, self-reported skin colour), and dietary intake measured using the online Australian Eating Survey((R)) (AES((R))). Multiple linear regression models were used to investigate factors associated with the dependent variable, skin yellowness (b*). Results: Participants were on average 38.6 (SD = 17.7) years of age, self-reported as female (61%), Caucasian (77%) and met the recommended fruit intake of two serves/day (mean = 2.1, SD = 1.5) but not the recommended vegetable intake of five to six serves per day (mean = 4.4, SD = 3.1). There were significant associations between skin yellowness (b*) and several independent variables, including combined fruit and vegetable intake, total carotenoid intake, body fat percentage and self-reported skin colour. Conclusions: This study adds additional support for using skin yellowness as a proxy for fruit and vegetable intake when adjusting for self-reported skin colour, age and sex. FAU - Jansson, Anna K AU - Jansson AK AUID- ORCID: 0000-0001-9039-2033 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW 2308, Australia. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia. FAU - Gomez-Martin, Maria AU - Gomez-Martin M AUID- ORCID: 0000-0001-7300-7471 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW 2308, Australia. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia. FAU - Clarke, Erin D AU - Clarke ED AUID- ORCID: 0000-0001-8250-5990 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW 2308, Australia. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia. FAU - Adam, Marc T P AU - Adam MTP AUID- ORCID: 0000-0002-6036-4282 AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia. AD - School of Computer and Information Sciences, University of Newcastle, Newcastle, NSW 2308, Australia. FAU - Collins, Clare E AU - Collins CE AUID- ORCID: 0000-0003-3298-756X AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW 2308, Australia. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia. LA - eng GR - APP2009340/National Health and Medical Research Council/ PT - Journal Article DEP - 20260827 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 36-88-4 (Carotenoids) SB - IM MH - Humans MH - *Fruit MH - Female MH - *Vegetables MH - Adult MH - Male MH - Middle Aged MH - Cross-Sectional Studies MH - *Skin Pigmentation MH - Carotenoids/analysis MH - Young Adult MH - *Diet MH - White People MH - Adolescent MH - Aged MH - Australia MH - Asian People PMC - PMC13566963 OTO - NOTNLM OT - cross-sectional OT - dietary intake OT - nutrition OT - reflectance spectroscopy OT - skin carotenoids COIS- The authors declare no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:23 PHST- 2026/07/28 00:00 [received] PHST- 2026/08/25 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - nu18172804 [pii] AID - nutrients-18-02804 [pii] AID - 10.3390/nu18172804 [doi] PST - epublish SO - Nutrients. 2026 Aug 27;18(17):2804. doi: 10.3390/nu18172804. PMID- 42738966 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 26 TI - Associations and Multidimensional Characterization of the Nutritional-Inflammatory Profile in Children with Previous SARS-CoV-2 Infection: A Retrospective Cohort Study. LID - 10.3390/nu18172793 [doi] LID - 2793 AB - Background/Objectives: Nutritional, inflammatory, and lifestyle-related characteristics may contribute to substantial biological heterogeneity among children with documented previous SARS-CoV-2 infection. This study aimed to characterize an integrated nutritional-inflammatory profile and explore its relationships with biological and clinical features in a hospitalized pediatric cohort. Methods: This retrospective cohort study included 260 children with documented previous SARS-CoV-2 infection. Clinical, anthropometric, and laboratory data were complemented by questionnaire-derived dietary and lifestyle information (n = 213). Analyses combined conventional statistics with correlation and multivariate techniques, including PCA and K-means clustering (n = 231) and exploratory Ridge regression (n = 188). Results: Suboptimal serum 25(OH)D concentrations (<30 ng/mL) were present in 55.8% of participants (95% CI [49.7%, 61.7%]), while 43.5% were overweight or obese (95% CI [37.6%, 49.5%]). BMI correlated with hemoglobin (rho = 0.23) and CRP (rho = 0.12), while 25(OH)D correlated with potassium (rho = 0.22). Increasing daily device use was associated with progressively lower 25(OH)D concentrations (H = 24, p < 0.001, epsilon(2) = 0.11), with median values decreasing from 33 ng/mL at <1 h/day to 24 ng/mL at >4 h/day. PCA identified three complementary biological dimensions explaining 55.0% of the total variance, while K-means clustering identified three reproducible exploratory nutritional-inflammatory phenotypes differentiated by age, BMI, hematological and inflammatory characteristics, and selected lifestyle factors. Conclusions: The findings show multidimensional nutritional-inflammatory heterogeneity in children with documented previous SARS-CoV-2 infection. The identified patterns and exploratory phenotypes provide an integrated framework for biological characterization and warrant validation in prospective multicenter cohorts. FAU - Petrea Cliveti, Carmen Loredana AU - Petrea Cliveti CL AUID- ORCID: 0009-0001-8838-8817 AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Ciortea, Diana-Andreea AU - Ciortea DA AUID- ORCID: 0000-0001-7420-256X AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Maria Sklodowska Curie" Emergency Clinical Hospital for Children, 041451 Bucharest, Romania. FAU - Gurau, Gabriela AU - Gurau G AUID- ORCID: 0000-0001-8327-1364 AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Matei, Madalina Nicoleta AU - Matei MN AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Barbu, Codrina AU - Barbu C AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Verga Rauta, Gabriela Isabela AU - Verga Rauta GI AUID- ORCID: 0009-0009-5438-666X AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Lungu, Irinel AU - Lungu I AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Valcan, Mariana Mirela AU - Valcan MM AUID- ORCID: 0000-0001-5347-4267 AD - Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania. FAU - Berbece, Sorin Ion AU - Berbece SI AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. LA - eng PT - Journal Article DEP - 20260826 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - *COVID-19 MH - Retrospective Studies MH - Female MH - SARS-CoV-2 MH - Child MH - Male MH - *Nutritional Status MH - Vitamin D/blood/analogs & derivatives MH - *Inflammation/blood MH - Adolescent MH - Life Style MH - Body Mass Index MH - Child, Preschool PMC - PMC13567281 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - children OT - exploratory phenotypes OT - inflammatory biomarkers OT - lifestyle OT - nutritional-inflammatory profile OT - previous SARS-CoV-2 infection OT - principal component analysis COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/08/26 CRDT- 2026/09/15 03:23 PHST- 2026/07/13 00:00 [received] PHST- 2026/08/20 00:00 [revised] PHST- 2026/08/22 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - nu18172793 [pii] AID - nutrients-18-02793 [pii] AID - 10.3390/nu18172793 [doi] PST - epublish SO - Nutrients. 2026 Aug 26;18(17):2793. doi: 10.3390/nu18172793. PMID- 42738956 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 26 TI - Beverage Consumption Patterns, Beverage-Derived Energy Intake, and Adherence to Fluid Intake Recommendations Among Polish Adolescents: A Cross-Sectional Study Using the BEVQ-PL Questionnaire. LID - 10.3390/nu18172784 [doi] LID - 2784 AB - Background/Objectives: Different organizations have established fluid intake recommendations for adolescents; however, studies assessing adherence typically rely on a single reference system, limiting comparisons across populations. This study assessed beverage consumption patterns and beverage-derived energy intake among Polish adolescents and examined how adherence estimates differed when recommendations issued by the European Food Safety Authority (EFSA), the Institute of Medicine (IOM), and the Polish National Institute of Public Health-National Institute of Hygiene (NIH) were applied. Methods: A cross-sectional study was conducted among 1644 secondary school students aged 14-18 years. Beverage consumption (mL/day) and beverage-derived energy intake (kcal/day) were assessed using the validated Polish Beverage Intake Questionnaire (BEVQ-PL). Adherence was defined as achieving at least 80% of the age- and sex-specific Adequate Intake (AI) from beverages, assuming that beverages provide approximately 80% of total daily water intake. Results: Water had the highest median daily intake (960 mL/day). Males consumed significantly more water than females (1080 vs. 720 mL/day; p = 0.037), whereas females consumed significantly more reduced-fat milk (2%), skim milk, plant-based and flavored milk beverages, 100% vegetable juice, and coffee with milk and sugar. Adherence differed according to the recommendation system, reaching 65.2% (EFSA), 50.6% (IOM), and 65.8% (NIH). Female sex was independently associated with higher adherence across all three reference systems, whereas older age was associated with lower adherence only according to the NIH criteria and overweight/obesity only according to the IOM criteria. Conclusions: Estimated adherence to fluid intake recommendations varied substantially according to the reference system applied. These findings highlight the importance of explicitly reporting the selected reference criteria when assessing and comparing the adequacy of beverage-derived fluid intake among adolescents. FAU - Zborowski, Marek AU - Zborowski M AUID- ORCID: 0000-0003-2695-2491 AD - The Faculty of Medicine and Health Sciences, University of Applied Sciences in Nowy Sacz, Kosciuszki 2G, 33-300 Nowy Sacz, Poland. FAU - Skotnicka, Magdalena AU - Skotnicka M AUID- ORCID: 0000-0002-0853-0685 AD - Department of Commodity Science, Faculty of Health Sciences, Medical University of Gdansk, 7 Debinki Street, 80-210 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260826 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - Male MH - *Beverages MH - Poland MH - *Energy Intake MH - *Drinking MH - Surveys and Questionnaires MH - Recommended Dietary Allowances MH - Animals MH - Guideline Adherence MH - *Patient Compliance PMC - PMC13567327 OTO - NOTNLM OT - BEVQ-PL OT - adequate intake OT - adolescents OT - beverage consumption OT - hydration recommendations COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/26 CRDT- 2026/09/15 03:23 PHST- 2026/08/01 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - nu18172784 [pii] AID - nutrients-18-02784 [pii] AID - 10.3390/nu18172784 [doi] PST - epublish SO - Nutrients. 2026 Aug 26;18(17):2784. doi: 10.3390/nu18172784. PMID- 42738947 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 25 TI - Association of Sleep Duration and Physical Activity with Healthy Eating Habits Among Peruvian Secondary School Students. LID - 10.3390/nu18172775 [doi] LID - 2775 AB - Background/Objectives: Sleep duration and physical activity are key behavioral components in the development of healthy lifestyles during adolescence. In Peru, a considerable proportion of school students do not meet recommended levels of physical activity and may also experience insufficient sleep, which could negatively affect their eating habits. This study aimed to analyze the association between sleep duration, physical activity level, and healthy eating habits among Peruvian secondary school students. Methods: An observational, analytical, cross-sectional study was conducted among 275 secondary school students aged 12 to 17 years. Sleep duration, physical activity, and eating habits were assessed using validated questionnaires. Associations were analyzed using Pearson's chi-square test and multivariable binary logistic regression. Results: Students who slept 7 h had higher odds of having healthy eating habits compared with those who slept 6 h or less (aOR = 2.525; 95% CI: 1.181-5.536; p = 0.018). In addition, students with low levels of physical activity showed lower odds of having healthy eating habits compared with those with high levels of physical activity (aOR = 0.097; 95% CI: 0.005-0.564; p = 0.032). Conclusions: Sleep duration and physical activity were associated with healthy eating habits among Peruvian secondary school students. These findings support the importance of promoting integrated school-based strategies that jointly address sleep, physical activity, and nutrition during adolescence. FAU - Remon-Lopez, Jennyfer A AU - Remon-Lopez JA AD - Escuela de Nutricion Humana, Facultad de Ciencias de la Salud, Universidad Peruana Union, Lima 15102, Peru. FAU - Chilon-Llico, Raquel AU - Chilon-Llico R AD - Escuela de Nutricion Humana, Facultad de Ciencias de la Salud, Universidad Peruana Union, Lima 15102, Peru. FAU - Peralta-Eugenio, Gutember AU - Peralta-Eugenio G AUID- ORCID: 0000-0002-1177-6088 AD - Facultad de Ciencias de la Salud, Escuela de Psicologia, Universidad Cesar Vallejo, Chimbote 02801, Peru. FAU - Morales-Garcia, Wilter C AU - Morales-Garcia WC AUID- ORCID: 0000-0003-1208-9121 AD - Facultad de Teologia, Universidad Peruana Union, Lima 15102, Peru. FAU - Sairitupa-Sanchez, Liset Z AU - Sairitupa-Sanchez LZ AUID- ORCID: 0000-0003-0555-091X AD - Escuela de Psicologia, Universidad Senor de Sipan, Chiclayo 14001, Peru. FAU - Morales-Garcia, Sandra B AU - Morales-Garcia SB AUID- ORCID: 0000-0002-5102-303X AD - Escuela de Medicina Humana, Universidad Senor de Sipan, Chiclayo 14001, Peru. FAU - Rivera-Lozada, Oriana AU - Rivera-Lozada O AD - Escuela de Medicina Humana, Universidad Senor de Sipan, Chiclayo 14001, Peru. FAU - Morales-Garcia, Mardel AU - Morales-Garcia M AUID- ORCID: 0000-0002-6413-1072 AD - Direccion de Investigacion, Escuela de Posgrado, Universidad Peruana Union, Lima 15102, Peru. LA - eng PT - Journal Article PT - Observational Study DEP - 20260825 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - *Sleep Duration MH - Peru MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - *Exercise MH - *Feeding Behavior MH - *Students/statistics & numerical data MH - *Diet, Healthy MH - Schools MH - Surveys and Questionnaires MH - Logistic Models MH - *Sleep MH - Adolescent Behavior PMC - PMC13567383 OTO - NOTNLM OT - Peru OT - adolescents OT - healthy eating habits OT - physical activity OT - sleep duration COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/25 CRDT- 2026/09/15 03:23 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - nu18172775 [pii] AID - nutrients-18-02775 [pii] AID - 10.3390/nu18172775 [doi] PST - epublish SO - Nutrients. 2026 Aug 25;18(17):2775. doi: 10.3390/nu18172775. PMID- 42738945 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 25 TI - The Gut-Brain Axis and Dietary Patterns in Shaping Long-Term Neurocognitive and Psychosocial Outcomes in Adolescent and Young Adult Survivors of Childhood Cancer: A Systematized Narrative Review. LID - 10.3390/nu18172773 [doi] LID - 2773 AB - Background: The dynamic advancement of pediatric hemato-oncology and intensified therapeutic protocols have significantly increased survival rates while simultaneously highlighting the challenge of long-term treatment complications. Within the cohort of adolescent and young adult (AYA) survivors, delayed neurocognitive deficits, often manifesting as the chemobrain phenotype, and psychosocial disorders constitute a particularly substantial burden. Contemporary neurogastroenterological evidence indicates a fundamental role of persistent dysbiosis and gut-brain axis dysfunction in the pathogenesis of these alterations. This review aims to critically synthesize translational evidence elucidating the impact of iatrogenic gut microbiota damage and modifiable dietary patterns on the development of long-term neurocognitive sequelae in survivors of early childhood cancer. Methods: A systematized narrative review was conducted in accordance with the SANRA guidelines by integrating data from in vivo models and observational studies. A comprehensive literature search across the PubMed, Embase, Cochrane Central, Scopus, and Web of Science databases up to June 2026 was performed utilizing the Population, Exposure, and Outcomes (PEO) framework. Results: Oncological therapies, including myeloablative conditioning and broad-spectrum antibiotic therapy, induce a microbial scar phenomenon characterized by the depletion of commensal Firmicutes in favor of resistant pathobionts. The subsequent decline in the synthesis of neuroprotective short-chain fatty acids (SCFAs) alongside the pathological activation of the kynurenine pathway disrupts central nervous system homeostasis. Translocation of lipopolysaccharides (LPSs) across the compromised intestinal barrier generates systemic inflammation recognized as inflammaging, which, in turn, stimulates neurotoxic microglial hyperreactivity. This pathophysiological cascade is accelerated by a pro-inflammatory Western diet, whereas anti-inflammatory interventions such as the MIND diet and postbiotics demonstrate measurable restorative potential. Conclusions: The pathophysiology of delayed neurotoxicity is largely a consequence of systemic neuroinflammation driven by intestinal dysbiosis. Implementing individualized dietary and microbiome-targeted strategies into survivorship care protocols constitutes a crucial direction for clinical prophylaxis. Validating their clinical efficacy in the AYA population necessitates prospective randomized controlled trials integrated with shotgun metagenomic sequencing. FAU - Pawlowski, Piotr AU - Pawlowski P AUID- ORCID: 0000-0002-1197-7218 AD - Department of Psychology, Psychosocial Aspects of Medicine, Faculty of Medicine, Medical University of Lublin, 20-093 Lublin, Poland. AD - Institute of Medical Sciences, University of Applied Sciences in Chelm, 22-100 Chelm, Poland. FAU - Kosciolek, Otylia AU - Kosciolek O AD - Student Scientific Club at the Department of Psychology, Faculty of Medicine, Medical University of Lublin, 20-093 Lublin, Poland. FAU - Jezak, Mikolaj AU - Jezak M AUID- ORCID: 0009-0009-2014-3985 AD - I Department of Anaesthesiology and Intensive Care, University Clinical Hospital No. 4 in Lublin, 20-090 Lublin, Poland. FAU - Jakubik, Karol AU - Jakubik K AUID- ORCID: 0009-0005-8880-3522 AD - Doctoral School, Medical University of Lublin, 20-093 Lublin, Poland. AD - I Department of Medical Radiology, Medical University of Lublin, 20-090 Lublin, Poland. FAU - Kosciolek, Aneta AU - Kosciolek A AUID- ORCID: 0000-0001-5712-1629 AD - Institute of Medical Sciences, University of Applied Sciences in Chelm, 22-100 Chelm, Poland. FAU - Samardakiewicz, Marzena AU - Samardakiewicz M AUID- ORCID: 0000-0002-2793-0756 AD - Department of Psychology, Psychosocial Aspects of Medicine, Faculty of Medicine, Medical University of Lublin, 20-093 Lublin, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260825 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - *Cancer Survivors/psychology MH - *Gastrointestinal Microbiome/physiology MH - Young Adult MH - *Diet MH - *Brain-Gut Axis/physiology MH - *Neoplasms/psychology MH - Dysbiosis MH - Child MH - *Brain PMC - PMC13567169 OTO - NOTNLM OT - adolescent and young adult (AYA) OT - childhood cancer survivors OT - dietary patterns OT - human gut microbiota OT - long-term follow-up (LTFU) OT - neurocognitive functioning OT - psychosocial functioning COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/25 CRDT- 2026/09/15 03:23 PHST- 2026/07/26 00:00 [received] PHST- 2026/08/20 00:00 [revised] PHST- 2026/08/23 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - nu18172773 [pii] AID - nutrients-18-02773 [pii] AID - 10.3390/nu18172773 [doi] PST - epublish SO - Nutrients. 2026 Aug 25;18(17):2773. doi: 10.3390/nu18172773. PMID- 42738936 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 24 TI - Prehabilitation Practices for Paediatric Haematopoietic Stem Cell Transplantation: A Survey and Patient and Public Involvement Study of Healthcare Professionals. LID - 10.3390/nu18172762 [doi] LID - 2762 AB - Background/Objectives: Haematopoietic stem cell transplantation (HSCT) causes substantial morbidity in children and young people (CYP). Although prehabilitation benefits adults with cancer, its role in paediatric HSCT remains underexplored. This study aimed to describe current pre-transplant assessment and supportive care practices across paediatric HSCT centres, explore healthcare professional perspectives on prehabilitation implementation, and integrate patient and public involvement (PPI) to inform future intervention design. Methods: A cross-sectional survey was administered to healthcare professionals across 16 paediatric HSCT centres in the UK and the Republic of Ireland, alongside semi-structured PPI discussions conducted with eight children, young people, and caregivers with direct experience of paediatric HSCT. Survey data were analysed descriptively, free-text responses by qualitative content analysis, and PPI by reflexive thematic analysis. Results: Forty-nine eligible responses were received from healthcare professionals. Formal prehabilitation services were reported by 27 (55.1%) respondents, with substantial within-centre variation. Nutritional advice was the most consistently delivered component, 36 (72%), whilst physical activity interventions were the least consistently provided, 13 (26%). Workforce limitations were identified as the dominant barrier by 37 (95%) respondents. PPI findings described provision as reactive and inconsistent, with families expressing preference for flexible, hybrid, and family-centred delivery models. Conclusions: Prehabilitation provision in paediatric HSCT is variable, often informal, and limited by workforce capacity. CYP and caregivers expressed a desire for prehabilitation, particularly through flexible, hybrid (face-to-face and online), and family-centred approaches. Future research should prioritise co-design and feasibility testing of safe, individually tailored programmes that can be integrated into paediatric HSCT pathways. FAU - AbuSalameh, Hala AU - AbuSalameh H AD - Public Health and Sports Sciences, Faculty of Life and Health Sciences, Medical School, University of Exeter, Exeter EX1 2LU, UK. FAU - Revuelta Iniesta, Raquel AU - Revuelta Iniesta R AUID- ORCID: 0000-0002-5534-7146 AD - Public Health and Sports Sciences, Faculty of Life and Health Sciences, Medical School, University of Exeter, Exeter EX1 2LU, UK. FAU - Rowley, Deborah AU - Rowley D AD - Public Health and Sports Sciences, Faculty of Life and Health Sciences, Medical School, University of Exeter, Exeter EX1 2LU, UK. AD - Haematology and Oncology, Sheffield Children's NHS Foundation Trust, Clarkson Street, Broomhall, Sheffield S10 2TH, UK. LA - eng GR - N/A/Children's Cancer and Leukaemia Group/ PT - Journal Article DEP - 20260824 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation MH - Cross-Sectional Studies MH - Child MH - Female MH - Adolescent MH - Male MH - Surveys and Questionnaires MH - *Patient Participation MH - United Kingdom MH - *Health Personnel MH - Ireland MH - *Preoperative Care/methods MH - Adult MH - Child, Preschool PMC - PMC13567236 OTO - NOTNLM OT - children and young people OT - haematopoietic stem cell transplantation OT - healthcare professionals OT - patient and public involvement OT - prehabilitation COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/24 CRDT- 2026/09/15 03:23 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - nu18172762 [pii] AID - nutrients-18-02762 [pii] AID - 10.3390/nu18172762 [doi] PST - epublish SO - Nutrients. 2026 Aug 24;18(17):2762. doi: 10.3390/nu18172762. PMID- 42738928 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 23 TI - Adverse Events Following Cow's Milk-Derived Human Milk Fortification: A Nationwide Human Milk Bank Study. LID - 10.3390/nu18172755 [doi] LID - 2755 AB - Background: Cow's milk-derived fortifier (CMDF) is widely used to improve the nutritional adequacy of human milk for very preterm infants. Although generally well-tolerated, feeding difficulties may occur during CMDF use. Characterizing these events and their associated clinical factors may improve the understanding of feeding tolerance in routine neonatal practice. Objective: To characterize documented adverse feeding events among infants receiving donor human milk (DHM) and CMDF and to identify clinical characteristics associated with these events. Methods: This retrospective nationwide cohort study used the Japanese Human Milk Bank Database. Infants receiving DHM and CMDF were included. Clinical characteristics were compared between infants with and without documented adverse feeding events, and multivariable logistic regression was used to evaluate associated factors. Results: Among the 2587 infants receiving DHM and CMDF, 2476 had available adverse-event information. Adverse feeding events were documented in 315 infants (12.7%), most commonly abdominal distension, increased gastric residuals, vomiting, and suspected cow's milk protein allergy. Infants with documented adverse feeding events had lower gestational age and birth weight and required longer to reach an enteral feeding volume of 100 mL/kg/day. In multivariable analysis, delayed achievement of 100 mL/kg/day remained associated with documented adverse feeding events, whereas gestational age, birth weight, and sex were not independently associated. Routine clinical variables showed limited discriminatory ability (AUC 0.611). Conclusions: Most infants receiving CMDF had no documented adverse feeding events. Slower progression to an enteral feeding volume of 100 mL/kg/day was associated with documented adverse feeding events; however, the temporal relationship among feeding progression, CMDF initiation, and adverse events could not be established. These findings should therefore be considered hypothesis-generating rather than predictive and require prospective validation. FAU - Tani, Yuki AU - Tani Y AUID- ORCID: 0009-0008-0402-1331 AD - Department of Pediatrics, Showa Medical University, Tokyo 142-8666, Japan. AD - Department of Pediatrics, Nara Medical University, Kashihara 634-8522, Japan. FAU - Mizuno, Katsumi AU - Mizuno K AUID- ORCID: 0000-0002-6983-8851 AD - Department of Pediatrics, Showa Medical University, Tokyo 142-8666, Japan. LA - eng GR - 25DA0601/Japan Child and Family Research Institute/ PT - Journal Article DEP - 20260823 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Milk, Human MH - Female MH - Retrospective Studies MH - *Milk Banks MH - Infant, Newborn MH - Animals MH - Male MH - *Food, Fortified/adverse effects MH - Japan MH - Enteral Nutrition MH - Infant, Premature MH - *Milk MH - Cattle MH - Infant MH - Milk Hypersensitivity/etiology PMC - PMC13567376 OTO - NOTNLM OT - cow's milk-derived fortifier OT - donor human milk OT - human milk fortification COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/23 CRDT- 2026/09/15 03:23 PHST- 2026/07/04 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/23 00:00 [pmc-release] AID - nu18172755 [pii] AID - nutrients-18-02755 [pii] AID - 10.3390/nu18172755 [doi] PST - epublish SO - Nutrients. 2026 Aug 23;18(17):2755. doi: 10.3390/nu18172755. PMID- 42738923 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 22 TI - Prenatal, Perinatal and Postnatal Exposures and Clinical Factors of Food Allergy Prevention: A Review for the First 1000 Days of Life from the SIAIP Primary and Secondary Prevention of Allergic Diseases Commission. LID - 10.3390/nu18172749 [doi] LID - 2749 AB - Food allergy prevention is no longer understood as the simple avoidance of allergenic foods. The first 1000 days (from conception to, approximately, 24 months of age) include prenatal, perinatal and postnatal windows in which diet, epithelial barrier integrity, microbial ecology, immune maturation and family-level implementation interact. This narrative review was developed as a Commission-proposed SIAIP-oriented clinical framework, rather than a formal guideline or consensus statement. Evidence from guidelines, systematic reviews, randomised trials, birth cohorts and mechanistic studies was organised by developmental window and interpreted according to endpoint validity, confounding, feasibility and clinical readiness. Prenatal factors include maternal allergen non-avoidance, whole-diet quality, micronutrient and fatty acid status, antibiotic exposure, environmental context and maternal microbiome. Perinatal factors include mode of delivery, intrapartum and neonatal antibiotics, gestational maturity, early colonisation, breastfeeding initiation and routine vaccination. Postnatal factors include eczema, skin barrier inflammation, the timing and regularity of allergen introduction, breastfeeding management, infant diet diversity, siblings, daycare, pets, smoke and pollution, physical activity and equitable implementation. The strongest actionable evidence remains eczema-linked risk recognition and timely, sustained oral exposure to peanut and well-cooked egg. Maternal and environmental factors are clinically important, but many are contextual rather than prescriptive; they should guide non-restrictive, non-blaming counselling rather than deterministic risk labelling. FAU - Klain, Angela AU - Klain A AUID- ORCID: 0000-0001-7823-2125 AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. FAU - Cascone, Salvatore AU - Cascone S AUID- ORCID: 0009-0009-6327-1119 AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. FAU - Grella, Carolina AU - Grella C AUID- ORCID: 0009-0006-5029-7895 AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. FAU - Cattivera, Valentina AU - Cattivera V AUID- ORCID: 0009-0008-6786-1506 AD - Department of Pediatrics, University of L'Aquila, 67100 L'Aquila, Italy. FAU - Fabiano, Cecilia AU - Fabiano C AD - Department of Pediatrics, University of L'Aquila, 67100 L'Aquila, Italy. FAU - Galletta, Francesca AU - Galletta F AUID- ORCID: 0000-0002-4166-2030 AD - Pediatric Unit, Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', University of Messina, 98124 Messina, Italy. FAU - Manti, Sara AU - Manti S AUID- ORCID: 0000-0001-5420-8411 AD - Pediatric Unit, Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', University of Messina, 98124 Messina, Italy. FAU - Senatore, Antonio Andrea AU - Senatore AA AUID- ORCID: 0000-0003-3377-9252 AD - Pediatric Clinic, Fondazione IRCCS Policlinico, 27100 Pavia, Italy. FAU - Licari, Amelia AU - Licari A AUID- ORCID: 0000-0002-1773-6482 AD - Pediatric Clinic, Fondazione IRCCS Policlinico, 27100 Pavia, Italy. AD - Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. FAU - Miraglia Del Giudice, Michele AU - Miraglia Del Giudice M AUID- ORCID: 0000-0002-8369-5957 AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. FAU - Marseglia, Gian Luigi AU - Marseglia GL AD - Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. FAU - Indolfi, Cristiana AU - Indolfi C AUID- ORCID: 0000-0002-9513-193X AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. CN - SIAIP Primary and Secondary Prevention of Allergic Diseases Commission LA - eng PT - Journal Article PT - Review DEP - 20260822 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Food Hypersensitivity/prevention & control MH - Female MH - Pregnancy MH - Infant MH - Infant, Newborn MH - Breast Feeding MH - *Prenatal Exposure Delayed Effects MH - Risk Factors MH - Diet MH - Developmental Origins of Health and Disease PMC - PMC13567279 OTO - NOTNLM OT - breastfeeding OT - children OT - eczema OT - environment OT - food allergy OT - microbiome OT - oral tolerance OT - perinatal factors OT - pregnancy OT - prevention OT - siblings OT - vaccination COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/22 CRDT- 2026/09/15 03:23 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/18 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/22 00:00 [pmc-release] AID - nu18172749 [pii] AID - nutrients-18-02749 [pii] AID - 10.3390/nu18172749 [doi] PST - epublish SO - Nutrients. 2026 Aug 22;18(17):2749. doi: 10.3390/nu18172749. PMID- 42738299 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260917 IS - 2072-6694 (Print) IS - 2072-6694 (Electronic) IS - 2072-6694 (Linking) VI - 18 IP - 17 DP - 2026 Aug 27 TI - Multi-Target HCC Blood Test Demonstrates Consistent Performance Across Subgroups of Patients with Chronic Liver Disease. LID - 10.3390/cancers18172777 [doi] LID - 2777 AB - BACKGROUND: Early detection of hepatocellular carcinoma (HCC) is critical for improving patient outcomes; however, ultrasound-based surveillance has limited sensitivity and variable performance across patient populations. We evaluated the performance of a multitarget HCC blood test (mt-HBT), incorporating methylated DNA markers, alpha-fetoprotein (AFP), and patient sex, across clinically relevant subgroups. METHODS: We performed a subgroup analysis of a multicenter, prospective case-control study that included 159 patients with early-stage HCC (Barcelona Clinic Liver Cancer Stage 0/A) and 649 control patients with cirrhosis or chronic hepatitis B without HCC. The mt-HBT combined methylated HOXA1, TSPYL5, and B3GALT6 markers with AFP and sex. Sensitivity and specificity were evaluated overall and according to age, sex, obesity, liver disease etiology, Child Pugh class, and tumor size. Performance was compared with AFP and GALAD. RESULTS: Overall sensitivity and specificity of mt-HBT for early-stage HCC detection were 76.7% (95% CI, 69.6-82.6) and 87.5% (95% CI, 84.8-89.8), respectively. Sensitivity was significantly higher than that of AFP (35.2%, p < 0.001) and comparable to that of GALAD (78.6%, p = 0.56), whereas specificity was lower than that of AFP (98.5%, p < 0.001) but higher than that of GALAD (76.9%, p < 0.001). Sensitivity was maintained across key subgroups, including patients with obesity (68.9%), Child Pugh B cirrhosis (75.0%), hepatitis C (80.0%), hepatitis B (72.2%), alcohol-associated liver disease (80.5%), and metabolic dysfunction-associated steatotic disease (69.0%) (all p > 0.05 between subgroups). Specificity exceeded 80% in all examined populations and was significantly higher in women than in men (92.5% vs. 83.9%, p < 0.001). Sensitivity increased with tumor size, ranging from 60.0% for tumors < 2 cm to 100% for tumors > 5 cm. CONCLUSIONS: The mt-HBT demonstrated robust, consistent performance for early-stage HCC detection across diverse patient populations, including subgroups in which ultrasound surveillance commonly underperforms. These findings support the prospective validation of mt-HBT as a blood-based surveillance strategy for HCC. FAU - Singal, Amit G AU - Singal AG AD - Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA. FAU - Camardo, Mark AU - Camardo M AD - Abbott, Madison, WI 53719, USA. FAU - Bruinsma, Janelle J AU - Bruinsma JJ AD - Abbott, Madison, WI 53719, USA. FAU - Kielar-Grevstad, Elle AU - Kielar-Grevstad E AD - Abbott, Madison, WI 53719, USA. FAU - Chalasani, Naga AU - Chalasani N AUID- ORCID: 0000-0003-4082-3178 AD - Department of Internal Medicine, Indiana University, Indianapolis, IN 46202, USA. FAU - John, Binu V AU - John BV AUID- ORCID: 0000-0002-2002-9682 AD - Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. AD - Division of Gastroenterology and Hepatology, Miami VA Health System, Miami, FL 33136, USA. LA - eng GR - U01 CA283935/CA/NCI NIH HHS/United States GR - U01 CA283935; U01 CA271887; P50 CA295495; CPRIT RP200554/CA/NCI NIH HHS/United States GR - I01 CX002654/CX/CSRD VA/United States GR - U01 CA271887/CA/NCI NIH HHS/United States GR - VA MERIT I01CX002654 01A1/VA clinical science research and development/ GR - P50 CA295495/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260827 PL - Switzerland TA - Cancers (Basel) JT - Cancers JID - 101526829 PMC - PMC13565293 OTO - NOTNLM OT - liver cancer OT - mt-HBT OT - screening OT - surveillance OT - ultrasound COIS- Dr. Singal has served as a consultant or on advisory boards for Genentech, AstraZeneca, Eisai, Exelixis, Bayer, Merck, Elevar, Boston Scientific, Sirtex, FujiFilm Medical Sciences, Exact Sciences, Helio Genomics, Roche, Glycotest, ImCare, Curve Bio, DELFI, Mursla, Universal Dx, and Abbott. Dr. Chalasani serves as a consultant to Madrigal, GSK, Altimmune, Insitro, Eccogene, Akero, Boston Pharmaceuticals, Zydus, He receives research support from Boerhinger-Ingelheim and Exact Sciences. He has equity in Heligenics, a drug discovery start-up company and Avant Sante, a contract research organization. Dr. John received institutional research support from Exact Sciences, Genentech, and Takeda. Dr. Bruinsma, Dr. Kielar-Grevstad, and Mr. Camardo are employees of Exact Sciences (now Abbott) and were involved in the study design, data interpretation, manuscript preparation, and review. All authors have reviewed and approved the final manuscript. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:22 PHST- 2026/07/30 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:22 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - cancers18172777 [pii] AID - cancers-18-02777 [pii] AID - 10.3390/cancers18172777 [doi] PST - epublish SO - Cancers (Basel). 2026 Aug 27;18(17):2777. doi: 10.3390/cancers18172777. PMID- 42737710 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 17 DP - 2026 Aug 31 TI - Enzyme-Specific Redox Stability and Plasticity in Trained Youth Athletes: Longitudinal Analysis of SOD and GPX. LID - 10.3390/ijms27177813 [doi] LID - 7813 AB - Resting antioxidant enzyme activity in youth athletes may reflect stable individual redox characteristics and developmentally modulated plasticity. This 12-month longitudinal analysis from the MuCAYA(plus) study examined the tracking of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in 69 trained athletes aged 10-17 years. Participants underwent repeated assessments of antioxidant enzyme activity, training exposure, body composition, and hematological parameters. Longitudinal tracking was evaluated using Pearson correlation and intraclass correlation coefficients, while change-score regression models tested whether changes in training exposure, growth-related variables, sex interactions, and hematological parameters predicted changes in SOD or GPX. In exploratory analyses, cluster-based redox phenotype stability was assessed using agreement statistics. Over 12 months, SOD decreased whereas GPX increased. GPX showed substantial tracking (r = 0.714, p < 0.001; ICC = 0.683), while SOD showed no meaningful tracking (r = 0.057, p = 0.644; ICC = 0.053). No statistically supported associations were detected between changes in training-exposure or growth-related measures and enzyme changes. Exploratory erythrocyte-related associations were observed for SOD, whereas leukocyte and platelet changes were unrelated. Cluster-based SOD/GPX phenotype analyses were not robust. These findings are compatible with a comparatively stronger trait-like component for GPX and greater state-like variability for SOD. FAU - Haferanke, Jonas AU - Haferanke J AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Dettenhofer, Maximilian AU - Dettenhofer M AUID- ORCID: 0009-0003-1733-6360 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Huber, Stefanie AU - Huber S AUID- ORCID: 0009-0002-0757-7681 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Muhlbauer, Frauke AU - Muhlbauer F AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Baumgartner, Lisa AU - Baumgartner L AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Engl, Tobias AU - Engl T AUID- ORCID: 0000-0002-6251-9532 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Schulz, Thorsten AU - Schulz T AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Oberhoffer, Renate AU - Oberhoffer R AUID- ORCID: 0000-0002-3166-0488 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Freilinger, Sebastian AU - Freilinger S AUID- ORCID: 0009-0000-3755-6481 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. LA - eng GR - 516547656/Deutsche Forschungsgemeinschaft/ PT - Journal Article DEP - 20260831 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - EC 1.15.1.1 (Superoxide Dismutase) RN - EC 1.11.1.9 (Glutathione Peroxidase) RN - 0 (Antioxidants) SB - IM MH - Humans MH - *Superoxide Dismutase/metabolism MH - *Glutathione Peroxidase/metabolism MH - *Athletes MH - Oxidation-Reduction MH - Adolescent MH - Male MH - Longitudinal Studies MH - Female MH - Child MH - Antioxidants/metabolism MH - Body Composition PMC - PMC13566580 OTO - NOTNLM OT - antioxidative capacity OT - glutathione peroxidase OT - oxidative stress OT - pediatric exercise science OT - physical activity OT - redox plasticity OT - superoxide dismutase OT - training adaptation OT - young athletes COIS- The authors declare no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/31 CRDT- 2026/09/15 03:21 PHST- 2026/07/27 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:21 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - ijms27177813 [pii] AID - ijms-27-07813 [pii] AID - 10.3390/ijms27177813 [doi] PST - epublish SO - Int J Mol Sci. 2026 Aug 31;27(17):7813. doi: 10.3390/ijms27177813. PMID- 42737413 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260929 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 17 DP - 2026 Aug 22 TI - Vitamin D and COVID-19: Inmunomodulatory Effects and the Mexican Public Health Perspectives. LID - 10.3390/ijms27177510 [doi] LID - 7510 AB - Vitamin D is a fat-soluble vitamin, considered a prohormone, that plays a fundamental role in calcium absorption and reabsorption, as well as the modulation of inflammatory response in infectious conditions such as COVID-19. A literature search was conducted in scientific databases and official sources, selecting studies published in the last 10 years in Spanish and English related to vitamin D and COVID-19; studies unrelated to the nutritional approach were excluded to reduce bias and ensure a rigorous and reproducible analysis. It was observed that the probability of contracting COVID-19 increases as the D3 hypovitaminosis prevalence increases. In Mexico, the relevance of vitamin D deficiency or supplementation in this disease has been controversial. Some studies claim that vitamin D supplementation could be a protective factor. According to the National Health Survey in Mexico (Ensanut), the Mexican population has significant deficiencies in this vitamin, contributing to an unfavorable diagnosis, particularly for children and pregnant women, as it is considered a deficiency in the blood when it is below 30 ng/mL and insufficiency when below 20 ng/mL, making these deficiencies important risk factors in the development of COVID-19 severe cases. Nevertheless, the use of vitamin D as an adjuvant agent in the treatment of COVID-19 can represent one of the main options for public health, providing therapeutic properties and health benefits. FAU - Munoz-Almaguer, Maria Luisa AU - Munoz-Almaguer ML AD - Department of Pharmacology, University Center of Applied Sciences and Engineering, University of Guadalajara, Guadalajara 44100, Mexico. FAU - Flores-Salas, Erick Yair AU - Flores-Salas EY AUID- ORCID: 0009-0004-9770-3884 AD - Department of Pharmacology, University Center of Applied Sciences and Engineering, University of Guadalajara, Guadalajara 44100, Mexico. FAU - Bancalari-Organista, Carlos AU - Bancalari-Organista C AD - Department of Pharmacology, University Center of Applied Sciences and Engineering, University of Guadalajara, Guadalajara 44100, Mexico. FAU - Escutia-Gutierrez, Raymundo AU - Escutia-Gutierrez R AUID- ORCID: 0000-0002-3072-0987 AD - Department of Pharmacology, University Center of Applied Sciences and Engineering, University of Guadalajara, Guadalajara 44100, Mexico. FAU - Virgen-Montelongo, Maria AU - Virgen-Montelongo M AD - Department of Pharmacology, University Center of Applied Sciences and Engineering, University of Guadalajara, Guadalajara 44100, Mexico. FAU - Avalos-Salgado, Felipe Alexis AU - Avalos-Salgado FA AUID- ORCID: 0000-0001-5328-4519 AD - Department of Pharmacology, University Center of Applied Sciences and Engineering, University of Guadalajara, Guadalajara 44100, Mexico. FAU - Franco-Torres, Esmeralda Marisol AU - Franco-Torres EM AD - Department of Pharmacology, University Center of Applied Sciences and Engineering, University of Guadalajara, Guadalajara 44100, Mexico. FAU - Corona-Espana, Ana Montserrat AU - Corona-Espana AM AUID- ORCID: 0009-0003-4604-3604 AD - Department of Chemistry, University Center of Applied Sciences and Engineering, University of Guadalajara, Guadalajara 44100, Mexico. LA - eng PT - Journal Article PT - Review DEP - 20260822 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 1406-16-2 (Vitamin D) SB - IM MH - Female MH - Humans MH - Pregnancy MH - *COVID-19/epidemiology MH - Dietary Supplements MH - Mexico/epidemiology MH - Pandemics MH - Public Health MH - *Vitamin D/therapeutic use MH - *Vitamin D Deficiency/epidemiology/complications/immunology PMC - PMC13565868 OTO - NOTNLM OT - COVID-19 OT - SARS-CoV-2 virus OT - Vitamin D OT - adjuvant OT - cytokines COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/22 CRDT- 2026/09/15 03:21 PHST- 2026/07/11 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:21 [entrez] PHST- 2026/08/22 00:00 [pmc-release] AID - ijms27177510 [pii] AID - ijms-27-07510 [pii] AID - 10.3390/ijms27177510 [doi] PST - epublish SO - Int J Mol Sci. 2026 Aug 22;27(17):7510. doi: 10.3390/ijms27177510. PMID- 42737394 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260916 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 17 DP - 2026 Sep 5 TI - Neonatal 2'-Fucosyllactose Supplementation Modulates Exploratory Behavior and Hippocampal Synaptic Plasticity in Rats Through Gut Microbiota and Metabolic Remodeling. LID - 10.3390/foods15173151 [doi] LID - 3151 AB - 2'-Fucosyllactose (2'-FL) represents a significant constituent within human milk oligosaccharides, and its benefits for intestinal health and neurodevelopment in infants and young children have been widely recognized. However, the mechanism by which 2'-FL influences early-life behavioral development through the gut-brain axis remains incompletely understood. In this study, we investigated the effects of neonatal 2'-FL supplementation on behavioral development in Sprague-Dawley (SD) rats and explored its potential microbiota-metabolite regulatory mechanisms. After 4 consecutive weeks of oral gavage beginning on postnatal day 2, rats receiving 2'-FL showed significantly increased average movement speed and central-area exploration time in the open field test. From a systemic perspective, 2'-FL lowered blood diamine oxidase (DAO) and D-lactic acid (D-LA) concentrations while elevating colonic mRNA levels of tight junction protein-related genes, consequently enhancing intestinal barrier stability. In addition, 16S rRNA sequencing showed that 2'-FL reshaped the gut microbiota structure and significantly enriched Lactobacillus, Bacteroides, and short-chain fatty acid (SCFA)-associated taxa represented by Lachnospiraceae_NK4A136_group. Untargeted metabolomics revealed that 2'-FL induced systemic metabolic remodeling, characterized by upregulation of the bioactive metabolites dehydroepiandrosterone sulfate (DHEA-S) and deoxycholic acid (DCA), and downregulation of the glucocorticoid-related corticosterone. Western blot validation further showed higher hippocampal protein expression of postsynaptic density protein 95 (PSD95), brain-derived neurotrophic factor (BDNF), and synaptophysin in the 2'-FL group, supporting enhanced synaptic plasticity-related signaling. In summary, neonatal 2'-FL intervention enhanced exploratory behavior and was accompanied by increased hippocampal synaptic plasticity-related protein expression in rats, potentially through coordinated regulation of gut microbiota composition and systemic metabolism. FAU - Yu, Miao AU - Yu M AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Wang, Jin AU - Wang J AUID- ORCID: 0000-0002-3312-8831 AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Kou, Ruixin AU - Kou R AUID- ORCID: 0009-0005-1613-2360 AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Xu, Bingye AU - Xu B AUID- ORCID: 0009-0003-3761-7506 AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Zhang, Weiqian AU - Zhang W AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Zhang, Ying AU - Zhang Y AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Liu, Jingmin AU - Liu J AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Wang, Shuo AU - Wang S AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. LA - eng GR - 24JCYBJC01770/Natural Science Foundation of Tianjin City/ GR - 63261094/Fundamental Research Funds for the Central Universities, Nankai University/ PT - Journal Article DEP - 20260905 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13565205 OTO - NOTNLM OT - 2'-fucosyllactose OT - behavioral development OT - gut microbiota OT - gut-brain axis OT - neonatal nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/05 CRDT- 2026/09/15 03:21 PHST- 2026/07/30 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:21 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - foods15173151 [pii] AID - foods-15-03151 [pii] AID - 10.3390/foods15173151 [doi] PST - epublish SO - Foods. 2026 Sep 5;15(17):3151. doi: 10.3390/foods15173151. PMID- 42736919 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260916 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 17 DP - 2026 Sep 1 TI - A CREATE-Based Educational Intervention to Improve Evidence-Based Practice Competencies in a Low-Income Country: A Feasibility Pilot Study. LID - 10.3390/healthcare14172763 [doi] LID - 2763 AB - BACKGROUND: Evidence-based practice (EBP) competencies remain limited in many low-income countries, where access to research training is often constrained by limited educational resources and humanitarian crises. This study evaluated the feasibility and preliminary effectiveness of a CREATE-based teaching strategy to improve EBP competencies among nurses and nursing students in Sudan. METHODS: A quasi-experimental pre-post study without a control group was conducted among 29 participants (17 registered nurses and 12 nursing students) at Comboni College, Port Sudan. The intervention consisted of a 40 h synchronous online educational program based on the CREATE framework, integrating interactive lectures, practical group exercises, teach-back activities, and the collaborative development of an evidence-based Kangaroo Mother Care protocol. EBP competencies were assessed before and after the intervention using the EBP-COQ and EBP-COQ Prof(c) questionnaires. Paired-sample t-tests were used to compare pre- and post-intervention scores. RESULTS: Nursing students demonstrated significant improvements in knowledge (p = 0.009), attitudes (p = 0.015), and overall EBP competency (p = 0.006), whereas changes in self-reported skills were not significant. Registered nurses showed significant improvements in knowledge (p < 0.001), skills (p < 0.001), and overall EBP competency (p < 0.001), while changes in attitudes and EBP utilization were not statistically significant. CONCLUSIONS: This pilot study suggests that a CREATE-based teaching strategy delivered through synchronous distance learning is feasible and may improve EBP competencies among nurses and nursing students in Sudan, despite the challenges of a resource-constrained and conflict-affected setting. Larger controlled studies are needed to confirm these findings and evaluate long-term educational and clinical outcomes. FAU - Marcomini, Ilaria AU - Marcomini I AUID- ORCID: 0000-0001-8096-0199 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. FAU - Buzzi, Federica AU - Buzzi F AUID- ORCID: 0000-0002-6470-9436 AD - IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. FAU - Poliani, Andrea AU - Poliani A AUID- ORCID: 0000-0002-6714-1057 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. FAU - Chiodi Daelli, Federico AU - Chiodi Daelli F AD - Italian Association for Solidarity Among Peoples (AISPO), 20132 Milan, Italy. FAU - Ciceri, Fabio AU - Ciceri F AUID- ORCID: 0000-0003-0873-0123 AD - IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. FAU - Naranjo Alcaide, Jorge Carlos AU - Naranjo Alcaide JC AUID- ORCID: 0000-0002-4287-5900 AD - Comboni College of Science and Technology, Port Sudan 33311, Sudan. FAU - Omer, Halima Ibrahim Malik Ali AU - Omer HIMA AUID- ORCID: 0000-0002-7097-0964 AD - Comboni College of Science and Technology, Port Sudan 33311, Sudan. FAU - Rosa, Debora AU - Rosa D AUID- ORCID: 0000-0002-1440-3092 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. FAU - Villa, Giulia AU - Villa G AUID- ORCID: 0000-0001-7429-0504 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. FAU - Zanuso, Rebecca AU - Zanuso R AD - Italian Association for Solidarity Among Peoples (AISPO), 20132 Milan, Italy. FAU - Marhoom, Mohja AU - Marhoom M AUID- ORCID: 0000-0003-3197-5225 AD - Comboni College of Science and Technology, Port Sudan 33311, Sudan. FAU - Manara, Duilio F AU - Manara DF AUID- ORCID: 0000-0001-5182-6994 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. LA - eng GR - Italian Association for Solidarity among Peoples (AISPO)/ PT - Journal Article DEP - 20260901 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13565826 OTO - NOTNLM OT - Sudan OT - evidence-based practice OT - low-income countries OT - maternal and child health OT - nursing education OT - remote education COIS- The authors declare no conflicts of interest, and the funder had no role in study design, data collection, data analysis or interpretation of results. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/01 CRDT- 2026/09/15 03:20 PHST- 2026/07/06 00:00 [received] PHST- 2026/08/23 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:20 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - healthcare14172763 [pii] AID - healthcare-14-02763 [pii] AID - 10.3390/healthcare14172763 [doi] PST - epublish SO - Healthcare (Basel). 2026 Sep 1;14(17):2763. doi: 10.3390/healthcare14172763. PMID- 42736809 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20261010 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 37 DP - 2026 Sep 11 TI - Continuous age-dependent centile curves and preliminary reference intervals for renal biomarkers and electrolytes in healthy Kenyan children under five years: A single-center cross-sectional study. PG - e50653 LID - 10.1097/MD.0000000000050653 [doi] LID - e50653 AB - Renal biomarkers change rapidly in early childhood, but pediatric reference intervals used in African laboratories are often extrapolated from non-African populations and discrete age partitions. This study derived continuous age-dependent centile curves and preliminary reference intervals for body mass index (BMI), serum creatinine, urea, and electrolytes in healthy Kenyan children aged 0 to 60 months. In this cross-sectional study, 176 children (90 males, 86 females) were systematically recruited at Kitui County Referral Hospital between June 2024 and February 2025. Children underwent clinical screening, World Health Organization-standard anthropometry, and morning fasting venous blood sampling. Creatinine and urea were measured using isotope-dilution mass spectrometry-traceable enzymatic assays, and electrolytes by direct ion-selective electrode. Centiles (2.5th, 50th, 97.5th) were estimated non-parametrically with 90% bootstrap confidence intervals, and continuous age trends modeled using generalized additive models for location, scale, and shape or quantile regression. BMI showed modest age-related variation, with median values rising from 15.8 kg/m2 (2.5th-97.5th: 11.4-20.2) at 0 to 11 months to 16.5 kg/m2 (10.1-23.0) at 48 to 60 months, with dispersion narrowing after age 2. Median creatinine rose steeply in infancy and more gradually thereafter, from 17.4 to 31.2 micromol/L. Urea increased gradually from a median of 2.59 to 3.63 mmol/L, with overlapping centile limits across adjacent strata. Electrolytes were tightly regulated and largely age-invariant: sodium ranged from 135 to 147 mmol/L (median ~141), potassium 3.6 to 5.7 mmol/L (median declining from 4.9 to 4.5), and chloride 100 to 111 mmol/L (median ~105-106). Sex-specific partitions were supported only in early life (BMI in infancy, creatinine in toddlers); correlations between anthropometric z-scores and biomarkers were weak (|rho| < 0.15; P > .10). These continuous centile curves provide the first preliminary age-dependent reference estimates for renal biomarkers in Kenyan children under 5, showing rapid early renal maturation alongside stable electrolyte homeostasis. As this cross-sectional design cannot capture within-subject variation, larger multicenter and longitudinal studies are needed to confirm these trajectories, refine intervals, and develop age-dependent z-score calculators for clinical use. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Nganda, Brian AU - Nganda B AUID- ORCID: 0009-0006-5981-1424 AD - Department of Medical Laboratory Sciences, School of Biomedical Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. FAU - Karanja, Peter AU - Karanja P AD - Department of Medical Laboratory Sciences, School of Biomedical Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. FAU - Muna, Kennedy AU - Muna K AD - Department of Medical Laboratory Sciences, School Pure, Applied, and Health Sciences, Murang'a University of Technology, Murang'a, Kenya. FAU - Moriasi, Gervason AU - Moriasi G AUID- ORCID: 0000-0001-5604-9987 AD - Department of Biochemistry, Microbiology, and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya. AD - Department of Medical Biochemistry, Medical School, Mount Kenya University, Thika, Kenya. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Biomarkers) RN - 0 (Electrolytes) RN - 8W8T17847W (Urea) RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Kenya MH - Male MH - Infant MH - *Biomarkers/blood MH - *Electrolytes/blood MH - Reference Values MH - *Urea/blood MH - *Creatinine/blood MH - Child, Preschool MH - Body Mass Index MH - Infant, Newborn MH - Age Factors MH - *Kidney PMC - PMC13574458 OTO - NOTNLM OT - diagnostic accuracy OT - generalized additive models OT - pediatric reference intervals OT - renal function biomarkers COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/11 CRDT- 2026/09/15 03:20 PHST- 2026/01/02 00:00 [received] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:20 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 00005792-202609110-00094 [pii] AID - MD-D-25-18841 [pii] AID - 10.1097/MD.0000000000050653 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Sep 11;105(37):e50653. doi: 10.1097/MD.0000000000050653. PMID- 42736733 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20261010 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 37 DP - 2026 Sep 11 TI - A machine learning model integrating radiomics and clinical factors to predict recurrence risk after rehabilitation in lumbar disc herniation. PG - e50454 LID - 10.1097/MD.0000000000050454 [doi] LID - e50454 AB - This study aimed to construct and internally validate a machine learning model integrating radiomics features and clinical factors to predict post-rehabilitation recurrence risk in patients with lumbar disc herniation (LDH). In this single-center retrospective cohort study, 260 adults aged 18 to 70 years with LDH who completed standardized rehabilitation were analyzed (78 with recurrence and 182 without recurrence). Radiomics features were extracted separately from sagittal T1-weighted, sagittal T2-weighted, and axial T2-weighted magnetic resonance imaging, standardized, concatenated across sequences, and reduced using least absolute shrinkage and selection operator regression. Three logistic regression models were developed: radiomics-only, clinical plus rehabilitation, and combined models. A stratified 70/30 split provided internal validation; receiver operating characteristic curves, calibration analysis, decision curve analysis, and risk stratification were used to evaluate performance. A separate multivariable logistic regression analysis was used to identify clinically interpretable predictors. Age, body mass index, disc height index, improvement in the Oswestry Disability Index, diabetes, Modic changes, and poor rehabilitation adherence differed significantly between the recurrence and non-recurrence groups (all P < .05). The combined model demonstrated the best predictive performance, with an area under the curve (AUC) of 0.85 (95% confidence interval: 0.78-0.91), outperforming the radiomics model (AUC = 0.78) and the clinical model (AUC = 0.76). The calibration curve showed strong agreement between predicted and observed recurrence, and decision curve analysis indicated superior net clinical benefit across a wide range of thresholds. Based on predicted probabilities, patients were stratified into low- (<20%), intermediate- (20%-40%), and high-risk (>40%) groups, with recurrence rates of 15.0%, 30.0%, and 66.0%, respectively (P < .001). Multivariable logistic regression identified disc height index (odds ratio [OR] = 1.80), Oswestry Disability Index improvement (OR = 0.65), poor rehabilitation adherence (OR = 2.50), diabetes (OR = 2.10), and Modic changes (OR = 1.90) as independent predictors of recurrence. Integrating multisequence weighted magnetic resonance imaging radiomics with clinical and rehabilitation variables improved internal prediction of post-rehabilitation recurrence in LDH. The combined model may support risk-adapted rehabilitation intensity and follow-up, but it requires prospective, multicenter external validation before routine clinical use. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Qi, Yanhong AU - Qi Y AD - Medical Department, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Feng, Yifei AU - Feng Y AD - Department of Medical Imaging, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Xing, Xiaoyue AU - Xing X AD - Department of Medical Imaging, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Wang, Zhe AU - Wang Z AD - Special Care Department, Beidaihe Rehabilitation and Recuperation Center, Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Yang, Yuwei AU - Yang Y AD - Medical Department, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Zhang, Lin AU - Zhang L AD - Medical Department, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Yu, Weiguo AU - Yu W AUID- ORCID: 0009-0000-1821-7919 AD - Department of Medical Imaging, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Radiomics MH - *Intervertebral Disc Displacement/rehabilitation/diagnostic imaging MH - *Machine Learning MH - Middle Aged MH - Adult MH - Retrospective Studies MH - Recurrence MH - *Lumbar Vertebrae/diagnostic imaging MH - Female MH - Magnetic Resonance Imaging/methods MH - Male MH - Predictive Learning Models MH - Aged MH - Logistic Models MH - ROC Curve MH - Young Adult MH - Adolescent MH - Risk Factors PMC - PMC13574428 OTO - NOTNLM OT - lumbar disc herniation OT - machine learning OT - predictive model OT - radiomics OT - recurrence OT - rehabilitation COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/11 CRDT- 2026/09/15 03:20 PHST- 2025/12/02 00:00 [received] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:20 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 00005792-202609110-00017 [pii] AID - MD-D-25-17232 [pii] AID - 10.1097/MD.0000000000050454 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Sep 11;105(37):e50454. doi: 10.1097/MD.0000000000050454. PMID- 42736577 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260916 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 18 IP - 1 DP - 2026 Aug 18 TI - Effectiveness of virtual reality-based balance training in primary school children: a randomized controlled trial. LID - 10.1186/s13102-026-02006-y [doi] LID - 415 AB - Balance and coordination are fundamental for children's motor development and injury prevention, yet sedentary lifestyles have contributed to their decline. Conventional balance training can be effective, but maintaining children's engagement remains challenging. Virtual reality (VR)-based programs provide immersive and gamified practice and may offer an alternative way to deliver balance- and coordination-related training in schools. This six-week randomized controlled trial compared immersive VR-based training with conventional training in 129 primary school students (VR: n = 64; control: n = 65). Participants trained three times per week for 30 min per session. Balance and coordination were assessed pre- and post-intervention using the Y-Balance Test (YBT composite score) as the primary dynamic-balance outcome, alongside single-leg stance with eyes closed (SLST-EC) and a 1-minute rope-skipping test. Both groups showed significant pre-post improvements across all outcomes (all p < 0.001), but within-group rope-skipping changes were not reliably interpretable as training effects because of likely test-retest familiarization, and SLST-EC changes were constrained by ceiling effects. Between-group comparisons of change scores showed no statistically significant differences for DeltaYBT, DeltaSLST-EC, or Deltarope skipping (all p > 0.05). An ANCOVA adjusting for baseline YBT also showed no group effect on post-intervention YBT (p = 0.442). Overall, immersive VR did not show a statistically significant advantage over conventional training matched for scheduled frequency and session duration in this six-week school-based trial. Trial registration: ISRCTN Registry, ISRCTN37850916, registered on 30 June 2026. Retrospectively registered. CI - (c) 2026. The Author(s). FAU - Zhang, Hongfei AU - Zhang H AUID- ORCID: 0009-0003-7134-7757 AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. FAU - Hu, Wenjun AU - Hu W AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. FAU - Kortas, Jakub AU - Kortas J AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. jakub.kortas@awf.gda.pl. LA - eng PT - Journal Article DEP - 20260818 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC13573351 OTO - NOTNLM OT - Balance training OT - Child health promotion OT - Exercise intervention OT - Motor coordination OT - Virtual reality COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Shanxi Engineering Vocational College (Ethics approval No. SEVC-2025-063). Written informed consent was obtained from the parents or legal guardians of all participating children before participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/18 CRDT- 2026/09/15 03:10 PHST- 2025/12/12 00:00 [received] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:10 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.1186/s13102-026-02006-y [pii] AID - 2006 [pii] AID - 10.1186/s13102-026-02006-y [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2026 Aug 18;18(1):415. doi: 10.1186/s13102-026-02006-y. PMID- 42736564 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260917 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 18 IP - 1 DP - 2026 Sep 12 TI - Characterization of eccentric hamstring strength and inter-limb asymmetry profiles in national-level youth male soccer players. LID - 10.1186/s13102-026-01980-7 [doi] LID - 416 AB - BACKGROUND: Eccentric hamstring strength and inter-limb asymmetry are commonly monitored in youth football; however, evidence comparing their magnitude and directional consistency across age categories remains limited. This study compared eccentric hamstring strength and inter-limb asymmetry magnitude between national-level U12 and U18 male footballers and assessed within-cohort agreement in stronger-limb classification. METHODS: In this cross-sectional study, 63 national-level male youth footballers were included: 35 U12 players aged approximately 12.0-12.9 years and 28 U18 players aged approximately 17.3-18.9 years. Participants completed repeated maximal bilateral Nordic Hamstring Exercise trials. Absolute peak force (PF), body mass-normalized peak force (RPF), inter-limb asymmetry magnitude, and stronger-limb classification were assessed. Trial-to-trial reliability was evaluated using coefficients of variation and intraclass correlation coefficients. Between-cohort differences in PF and RPF were examined using independent-samples t-tests, whereas the Mann-Whitney U test was used for inter-limb asymmetry. Hedges' g quantified between-cohort effect sizes, and Cohen's kappa assessed agreement in stronger-limb classification across trials. RESULTS: The U18 cohort demonstrated greater absolute PF (383.1 +/- 37.8 vs. 230.7 +/- 46.6 N; g = 3.51, p < 0.001) and RPF (5.1 +/- 0.5 vs. 4.5 +/- 0.6 N.kg(-)(1); g = 1.01, p < 0.001) than the U12 cohort. Inter-limb asymmetry was greater in U12 players (4.5 +/- 2.3%) than in U18 players (3.3 +/- 2.8%; g = - 0.48, p = 0.036). The U12 cohort demonstrated substantial within-cohort agreement in stronger-limb classification (kappa = 0.860, p < 0.001), whereas no evidence of agreement was observed in the U18 cohort (kappa = -0.143, p = 0.450). CONCLUSIONS: National-level U18 male footballers exhibited greater absolute and body mass-normalized eccentric hamstring strength and lower mean inter-limb asymmetry than U12 players. The U12 cohort showed substantial within-cohort agreement in stronger-limb classification, whereas no evidence of agreement was observed in the U18 cohort. Strength magnitude, asymmetry magnitude, and asymmetry direction should therefore be interpreted as complementary monitoring indicators, preferably alongside repeated assessments rather than as interchangeable measures. CI - (c) 2026. The Author(s). FAU - Wang, Jiaxin AU - Wang J AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Jiang, Dongting AU - Jiang D AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. AD - School of Coaching, Shanghai University of Sport, Shanghai, 200438, China. FAU - Bishop, Chris AU - Bishop C AD - Faculty of Science and Technology, London Sport Institute, London, NW4 1RL, UK. FAU - Zhou, Changjing AU - Zhou C AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Lyu, Mengde AU - Lyu M AD - School of Biomedical Science and Health, Royal Melbourne Institute of Technology University, Melbourne, Australia. FAU - Zheng, Hang AU - Zheng H AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Tang, Yue AU - Tang Y AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Bi, Zhiyuan AU - Bi Z AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Li, Yongming AU - Li Y AUID- ORCID: 0000-0001-9654-0199 AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. liyongming@sus.edu.cn. AD - China Institute of Sport Science, Beijing, 100061, China. liyongming@sus.edu.cn. AD - School of Coaching, Shanghai University of Sport, Shanghai, 200438, China. liyongming@sus.edu.cn. LA - eng PT - Journal Article DEP - 20260912 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC13576348 OTO - NOTNLM OT - Age-group comparison OT - Body mass normalization OT - Nordic hamstring exercise OT - Peak force OT - Stronger-limb consistency OT - Trial-to-trial reliability COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Shanghai University of Sport (Approval No. 102772025RT222). Written informed consent was obtained from adult participants and from the parents or legal guardians of all minor participants before enrollment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/12 CRDT- 2026/09/15 03:05 PHST- 2026/05/31 00:00 [received] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:05 [entrez] PHST- 2026/09/12 00:00 [pmc-release] AID - 10.1186/s13102-026-01980-7 [pii] AID - 1980 [pii] AID - 10.1186/s13102-026-01980-7 [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2026 Sep 12;18(1):416. doi: 10.1186/s13102-026-01980-7. PMID- 42736550 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Sep 10 TI - Effectiveness of a digi-physical tool and working method for paediatric obesity treatment in Abu Dhabi: a non-inferiority intervention study using an external historical comparator. LID - 10.1186/s12887-026-07623-7 [doi] LID - 868 AB - BACKGROUND: Effective paediatric obesity treatment requires high intensity, scalable interventions. A digi-physical tool for paediatric obesity treatment has shown positive results in Stockholm, Sweden. This study evaluates whether the same treatment method is effective in a different cultural setting. METHODS: This non-inferiority intervention study, using an external historical comparator, included 60 consecutively recruited children aged 6-15.9 years with obesity who initiated treatment at Sheikh Shakhbout Medical City in Abu Dhabi between June and December 2023. Patients were treated with Evira, a digi-physical tool and working method enabling high intensity individualized care, real-time monitoring, and interactive patient-clinician communication. The primary outcome was BMI z-score change at 26 weeks. Non-inferiority was assessed using a predefined margin of 0.10 BMI z-score, with outcomes compared to a prior published trial in Stockholm (n = 107). RESULTS: A total of 112 children were included in the analysis (Abu Dhabi cohort, n = 35; Stockholm cohort, n = 77). The adjusted mean change in BMI z-score was - 0.20 (95% CI: - 0.28, - 0.12) in the Abu Dhabi cohort and - 0.20 (- 0.26, - 0.14) in the Stockholm cohort (p = 0.88). Non-inferiority was confirmed, (predefined margin 0.10 was not exceeded). A clinically significant BMI z-score reduction (>/= 0.20 units) was achieved by 45.7% of participants in Abu Dhabi and 36.4% in Stockholm (p = 0.35). Non-retention rates at 26 weeks were 41.7% vs. 28.0%, respectively (p = 0.07). CONCLUSIONS: The findings provide promising evidence that treatment outcomes achieved with the digi-physical treatment tool were comparable in the Abu Dhabi and Stockholm cohorts, supporting its feasibility in a second cultural and healthcare setting. CI - (c) 2026. The Author(s). FAU - Lindberg, Louise AU - Lindberg L AD - Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. louise.lindberg@ki.se. AD - Evira AB, Triewaldsgrand 2, Stockholm, Sweden. louise.lindberg@ki.se. FAU - Hassan Beck, Reem AU - Hassan Beck R AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. FAU - Danielsson, Pernilla AU - Danielsson P AD - Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. FAU - Nielsen, Timmy AU - Nielsen T AD - Evira AB, Triewaldsgrand 2, Stockholm, Sweden. FAU - Abdalla, Asmahan AU - Abdalla A AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. FAU - Ekstedt, Peter AU - Ekstedt P AD - Swedish Health, Dubai, United Arab Emirates. FAU - Chaturvedi, Deepti AU - Chaturvedi D AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. FAU - Al Qahtani, Nabras AU - Al Qahtani N AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. FAU - Marcus, Claude AU - Marcus C AD - Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. AD - Evira AB, Triewaldsgrand 2, Stockholm, Sweden. FAU - Deeb, Asma AU - Deeb A AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. AD - Faculty of Health & Science, Khalifa University, Abu Dhabi, United Arab Emirates. LA - eng PT - Equivalence Trial PT - Journal Article DEP - 20260910 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Pediatric Obesity/therapy MH - Adolescent MH - Sweden MH - Body Mass Index MH - Treatment Outcome PMC - PMC13573347 OTO - NOTNLM OT - Digital health OT - Home-weighing OT - Non-inferiority intervention study OT - Paediatric obesity OT - Treatment outcome COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the declaration of Helsinki and approved by the Institution Review Board of SSMC, Abu Dhabi (SSMCREC-395) as well as the Stockholm Ethics Committee (approval no. 2018/1413-31, amendment 2024-06085-02). The study is retrospectively registered on Clinicaltrials.gov (ID: NCT06665893) 2024-10-29. Eligible patients were invited to participate, after receiving both oral and written information from one of the study clinicians. Informed consent was obtained from the parents or legal guardians. Consent for publication: Not applicable. Competing interests: LL and TN are employees of, and have share rights in, Evira AB. CM is a board member and shareholder of Evira AB. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/10 CRDT- 2026/09/15 02:57 PHST- 2025/04/08 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 02:57 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - 10.1186/s12887-026-07623-7 [pii] AID - 7623 [pii] AID - 10.1186/s12887-026-07623-7 [doi] PST - epublish SO - BMC Pediatr. 2026 Sep 10;26(1):868. doi: 10.1186/s12887-026-07623-7. PMID- 42736520 OWN - NLM STAT- Publisher LR - 20260915 IS - 1933-7205 (Electronic) IS - 1933-7191 (Linking) DP - 2026 Sep 14 TI - Circulating Fatty Acid-Binding Protein 4 (FABP4) in Adolescents with Polycystic Ovary Syndrome: Metabolic Correlates and Diagnostic Performance. LID - 10.1007/s43032-026-02189-2 [doi] AB - To compare circulating fatty acid-binding protein 4 (FABP4) concentrations in adolescents with polycystic ovary syndrome (PCOS) and controls, examine its metabolic correlates, and evaluate its diagnostic performance. This prospective observational study included 88 adolescents (44 PCOS, 44 controls) aged 10-19 years. PCOS was diagnosed using 2023 ESHRE/ASRM criteria. Clinical, anthropometric, and biochemical parameters were assessed. Serum FABP4 was measured via ELISA. Statistical analyses included multivariable linear regression, Firth's penalized logistic regression, and receiver operating characteristic (ROC) curves. Median FABP4 levels were significantly higher in adolescents with PCOS compared to controls (5.74 vs. 3.59 ng/mL, p < 0.001). Multivariable linear regression demonstrated that PCOS status, body mass index (BMI), and insulin resistance (HOMA-IR) associated with higher FABP4 concentrations. Multivariable logistic regression identified free androgen index (FAI) and FABP4 as variables independently associated with PCOS. ROC analysis showed FABP4 (> 4.08 ng/mL) yielded an area under the curve (AUC) of 0.849 (81.8% sensitivity, 75.0% specificity). The combination of FABP4 and FAI improved model discrimination compared with FAI alone (DeltaAUC = 0.133, p = 0.001), and this improvement remained significant after BMI adjustment. Circulating FABP4 is elevated in adolescents with PCOS and is associated with PCOS status, BMI, and insulin resistance. In this cohort, FABP4 provided complementary metabolic information when interpreted alongside FAI; however, BMI-matched, body composition-characterized, and externally validated studies are needed before FABP4 can be considered a clinically generalizable adjunctive biomarker in adolescent PCOS. CI - (c) 2026. The Author(s), under exclusive licence to Society for Reproductive Investigation. FAU - Codal, Bahadir AU - Codal B AUID- ORCID: 0000-0003-0044-9820 AD - Department of Obstetrics and Gynecology Bursa, Nev Anadolu Hospital, Nev Anadolu Hospital, 16110, Bursa, Turkiye. bahadrcodal@gmail.com. FAU - Kurt, Ahmet AU - Kurt A AUID- ORCID: 0000-0001-8402-5675 AD - Department of Obstetrics and Gynecology, Gemlik State Hospital, Bursa, Turkiye. FAU - Kaplan, Hacer AU - Kaplan H AUID- ORCID: 0009-0005-9240-4065 AD - Department of Obstetrics and Gynecology, Etlik City Hospital, Ankara, Turkiye. FAU - Cakir, Ayberk AU - Cakir A AUID- ORCID: 0000-0001-5749-4556 AD - Department of Obstetrics and Gynecology, Acibadem University Atakent Hospital, Istanbul, Turkiye. FAU - Hizli, Burak AU - Hizli B AUID- ORCID: 0009-0004-6060-1761 AD - School of Medicine, Department of Obstetrics and Gynecology, Usak University, Usak, Turkiye. FAU - Ozler, Mustafa Rasit AU - Ozler MR AUID- ORCID: 0000-0001-5911-6786 AD - Department of Perinatology, Bursa City Hospital, Bursa, Turkiye. LA - eng PT - Journal Article DEP - 20260914 PL - United States TA - Reprod Sci JT - Reproductive sciences (Thousand Oaks, Calif.) JID - 101291249 SB - IM OTO - NOTNLM OT - Adipokines OT - Adolescent OT - Biomarkers OT - Fatty acid-binding protein 4 OT - Hyperandrogenism OT - Insulin resistance OT - Polycystic ovary syndrome COIS- Declarations. Ethics Approval and Consent to Participate: The study protocol was approved by the Acibadem Mehmet Ali Aydinlar University Medical Research Evaluation Commission (ATADEK) (Approval No: ATADEK-2026-01/07). The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants and their legal guardians prior to enrollment. Consent for Publication: The authors declare that they agree to publication. Conflict of interest: The authors declare that there is no conflict of interest regarding the publication of this article. No financial or personal relationships exist that could inappropriately influence or bias the content of the work. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:36 CRDT- 2026/09/15 02:51 PHST- 2026/03/17 00:00 [received] PHST- 2026/08/15 00:00 [accepted] PHST- 2026/09/15 05:36 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 02:51 [entrez] AID - 10.1007/s43032-026-02189-2 [pii] AID - 10.1007/s43032-026-02189-2 [doi] PST - aheadofprint SO - Reprod Sci. 2026 Sep 14. doi: 10.1007/s43032-026-02189-2. PMID- 42736084 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1933-2874 (Print) IS - 1876-4789 (Linking) VI - 20 IP - 10 DP - 2026 Oct TI - Beyond conventional lipid panel: Estimated small dense and triglyceride-rich LDL cholesterol are associated with prediabetes independently of obesity in adolescents. PG - 2255-2266 LID - S1933-2874(26)00493-9 [pii] LID - 10.1016/j.jacl.2026.08.017 [doi] AB - BACKGROUND: Childhood obesity is strongly associated with insulin resistance and atherogenic dyslipidemia. Novel lipid indices such as small dense low-density lipoprotein cholesterol (sdLDL-C) and triglyceride-rich LDL (LDL-TG), along with the triglyceride-glucose (TyG) index, may improve early detection of metabolic risk, but their role in adolescents remains unclear. OBJECTIVE: To evaluate the association of calculated lipid indices (sdLDL-C, LDL-TG) and the TyG index with adiposity and prediabetes, and to assess their discriminative performance beyond conventional lipid parameters. METHODS: We conducted a retrospective cross-sectional study including 1302 adolescents aged 10 to 19 years. Participants were classified by body mass index (BMI) category. Calculated lipid indices and TyG were derived from routine laboratory data. Multinomial logistic regression assessed associations with overweight and obesity. A matched case-control analysis (n = 154 pairs) evaluated independent associations with prediabetes, including a secondary model matched for LDL-C. Discriminative ability was assessed using receiver operating characteristic curves. RESULTS: All metabolic markers increased progressively with BMI (P < 0.001). The TG/high-density lipoprotein cholesterol (HDL-C) ratio showed the strongest association with obesity (standardized OR 7.17). In matched analyses, TyG, sdLDL-C, LDL-TG, and TG/HDL-C were independently associated with prediabetes. In the LDL-C matched model, TyG remained strongly associated (P < 0.001), while sdLDL-C and LDL-TG retained independent associations. TyG showed the highest discriminative ability for prediabetes (areas under the curve [AUC] 0.678); sdLDL-C, LDL-TG, and TG/HDL-C showed comparable, more modest discriminative power (AUC 0.586-0.601). CONCLUSION: Calculated lipid indices capture early atherogenic lipoprotein remodeling in adolescents, independently of adiposity and LDL-C. While TyG is the strongest marker of glucose dysregulation, lipid-derived indices provide complementary information on cardiometabolic risk. These accessible markers may provide complementary, independent information for early risk stratification using routine laboratory data. CI - Copyright (c) 2026 National Lipid Association. Published by Elsevier Inc. All rights reserved. FAU - Cardozo Madaf, Abi AU - Cardozo Madaf A AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky). FAU - Oliveras Barri, Carola AU - Oliveras Barri C AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky). FAU - Gomez, Maria Eugenia AU - Gomez ME AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky). FAU - Perazzi, Beatriz AU - Perazzi B AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina (Perazzi and Berg). FAU - Berg, Gabriela AU - Berg G AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina (Perazzi and Berg); Programa de control de enfermedades cardiovasculares (PROCORDIS), Fundacion Bioquimica Argentina, Buenos Aires, Argentina (Berg). FAU - Lucero, Diego AU - Lucero D AD - Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA (Lucero); Department of Physiology, University of Kentucky, Lexington, KY, USA (Lucero). FAU - Fernandez Machulsky, Nahuel AU - Fernandez Machulsky N AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky). Electronic address: nh.machulsky@docente.ffyb.uba.ar. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - J Clin Lipidol JT - Journal of clinical lipidology JID - 101300157 RN - 0 (Triglycerides) RN - 0 (Cholesterol, LDL) SB - IM MH - Humans MH - *Prediabetic State/blood/complications MH - Adolescent MH - *Triglycerides/blood MH - Male MH - Female MH - *Cholesterol, LDL/blood MH - Child MH - *Obesity/blood/complications MH - Retrospective Studies MH - Cross-Sectional Studies MH - Young Adult MH - Body Mass Index OTO - NOTNLM OT - Adolescent OT - Insulin resistance OT - Obesity OT - Prediabetes OT - Small dense LDL cholesterol OT - Triglyceride-glucose index OT - Triglyceride-rich LDL COIS- Declaration of competing interest The authors declare that they have no conflict of interest EDAT- 2026/09/15 05:06 MHDA- 2026/10/28 23:26 CRDT- 2026/09/14 21:52 PHST- 2026/04/23 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/10/28 23:26 [medline] PHST- 2026/09/15 05:06 [pubmed] PHST- 2026/09/14 21:52 [entrez] AID - S1933-2874(26)00493-9 [pii] AID - 10.1016/j.jacl.2026.08.017 [doi] PST - ppublish SO - J Clin Lipidol. 2026 Oct;20(10):2255-2266. doi: 10.1016/j.jacl.2026.08.017. Epub 2026 Aug 31. PMID- 42734924 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1873-5843 (Electronic) IS - 0887-6177 (Linking) VI - 41 IP - 7 DP - 2026 Sep 9 TI - Characterizing neuropsychological performance and its nutritional, visual, and physiological correlates in children. LID - acag071 [pii] LID - 10.1093/arclin/acag071 [doi] AB - OBJECTIVE: To characterize neuropsychological performance in Ghanaian preadolescent children and examine its associations with demographic, health, nutritional, and visual factors. METHODS: A cross-sectional study was conducted among 290 preadolescent school children (median age: 11.0 years [IQR: 2.0]; range: 8-11 years; 54.8% female) from urban and rural public and private schools in the Ashanti Region of Ghana. Neuropsychological function was assessed using the Cambridge Neuropsychological Test Automated Battery, covering memory, executive function, attention, and psychomotor domains (minimum analytical sample: n = 150). Spearman's rank correlations assessed convergent validity and domain-specific independence. Associations between participant characteristics and cognitive performance were examined using multivariable linear regression, with Benjamini-Hochberg false discovery rate (FDR) correction applied across all regression tests. Statistical significance was defined as an FDR-adjusted q < 0.05, whereas both unadjusted p-values and adjusted q-values were reported for transparency. RESULTS: Cognitive performance exhibited a predominantly modular structure, characterized by strong within-task coherence and limited cross-domain integration. Males performed better than females on visual learning and psychomotor speed tasks, particularly Paired Associates Learning and movement reaction time measures (p < .05), whereas simple reaction time did not differ between sexes (p > .05). Following Benjamini-Hochberg FDR correction, no associations between cognitive performance and demographic, health, nutritional, or visual factors remained statistically significant. CONCLUSION: Neuropsychological functioning in Ghanaian preadolescent children appears to be predominantly modular, with limited evidence that demographic, health, nutritional, or visual factors are independently associated with cognitive performance after correction for multiple comparisons. CI - (c) The Author(s) 2026. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Osei Duah Junior, Isaiah AU - Osei Duah Junior I AUID- ORCID: 0000-0003-4501-8602 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. AD - Department of Psychology, John R. and Kathy R. Hairston College of Health and Human Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, United States of America. FAU - Ashon, Nana Aba Senuwah AU - Ashon NAS AUID- ORCID: 0009-0009-4618-8321 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Ofori-Asare, Wendy AU - Ofori-Asare W AUID- ORCID: 0009-0001-2401-9561 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Johnson, Elizabeth J AU - Johnson EJ AUID- ORCID: 0000-0002-8508-0032 AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, United States of America. FAU - Amoako, Mary AU - Amoako M AUID- ORCID: 0000-0001-9387-2286 AD - Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Adu-Owusu, Dorcas AU - Adu-Owusu D AUID- ORCID: 0009-0000-7594-3626 AD - Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Boateng, Josephine Ampomah AU - Boateng JA AUID- ORCID: 0009-0004-3522-5012 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Boateng, Charllote AU - Boateng C AUID- ORCID: 0009-0009-3778-1318 AD - Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, TN 38152, United States of America. FAU - Akuffo, Kwadwo Owusu AU - Akuffo KO AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. LA - eng GR - N.A.S.A./ PT - Journal Article PL - United States TA - Arch Clin Neuropsychol JT - Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists JID - 9004255 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Neuropsychological Tests MH - Cross-Sectional Studies MH - *Psychomotor Performance/physiology MH - *Executive Function/physiology MH - *Attention/physiology MH - Ghana MH - Processing Speed MH - *Cognition/physiology MH - Memory/physiology MH - *Nutritional Status/physiology MH - *Visual Perception/physiology MH - Reaction Time/physiology OTO - NOTNLM OT - attention OT - cognitive enhancements OT - executive functions OT - gender effects OT - learning and memory OT - perception/spatial processing EDAT- 2026/09/14 17:40 MHDA- 2026/09/14 17:41 CRDT- 2026/09/14 11:33 PHST- 2026/03/30 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/14 17:41 [medline] PHST- 2026/09/14 17:40 [pubmed] PHST- 2026/09/14 11:33 [entrez] AID - 8793661 [pii] AID - 10.1093/arclin/acag071 [doi] PST - ppublish SO - Arch Clin Neuropsychol. 2026 Sep 9;41(7):acag071. doi: 10.1093/arclin/acag071. PMID- 42734311 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1970-7096 (Electronic) IS - 1827-1987 (Linking) VI - 21 IP - 2 DP - 2026 Jul 23 TI - Household-level spatial modelling of child height-for-age in Northern Province, Rwanda: comparison of geographically weighted and neural network weighted regression models. LID - 10.4081/gh.2026.1491 [doi] AB - Childhood stunting remains a major public health concern in low- and middle-income countries, with persistent sub-national disparities. This study examined spatially varying associations between Height-for-Age z-scores (HAZ) and selected child, maternal, and household factors, and compared Geographically Weighted Regression (GWR), Multi-scale GWR (MGWR) and Geographically Neural Network Weighted Regression (GNNWR) in their ability to capture spatial heterogeneity and non-linearity. We analysed data from a cross-sectional survey conducted in December 2021 in the Northern Province of Rwanda. The survey covered 615 households, with analyses performed for 601 children aged 1-36 months. After imputation, multicollinearity screening, and feature selection, HAZ was modelled using Ordinary Least Squares (OLS), GWR, MGWR and GNNWR. Model performance was assessed using coefficient of determination (R2), Root Mean Square Error (RMSE), Akaike Information Criterion/AIC Corrected (AIC/AICc), and Moran's I of residuals. Overall stunting prevalence was 27.1%. Spatially varying associations were observed for child age, sex, birthweight, underweight status, selected childcare practices, maternal support, and household living conditions. GNNWR achieved the best training performance (R2 = 0.66; RMSE=0.74) followed by MGWR (R2 =0.51; RMSE=0.88) and GWR (R2 =0.43; RMSE=0.95). Validation performance declined for all models, although GNNWR retained a higher validation (R2=0.28) with negligible residual spatial autocorrelation (Moran's I = -0.005). GNNWR provided the strongest overall fit among the compared models and highlighted local spatial variation in associations with HAZ. However, the modest validation performance indicates that the findings should be interpreted cautiously. The workflow offers a portable framework for analysing DHS-like geocoded household datasets, but broader applicability should be assessed using spatial cross-validation, and sensitivity analyses. FAU - Kagoyire, Clarisse AU - Kagoyire C AD - Department of Earth and Environmental Sciences, Lund University, Lund, Sweden; Centre for GIS and Remote Sensing, College of Science and Technology, University of Rwanda, Kigali. FAU - Nduwayezu, Gilbert AU - Nduwayezu G AD - Department of Earth and Environmental Sciences, Lund University, Lund, Sweden; Department of Civil, Environmental and Geomatics Engineering, College of Science and Technology, University of Rwanda, Kigali. FAU - Oucheikh, Rachid AU - Oucheikh R AD - Department of Earth and Environmental Sciences, Lund University, Lund. FAU - Bizimana, Jean Pierre AU - Bizimana JP AD - Department of Spatial Planning, School of Architecture and Built Environment, College of Science and Technology, University of Rwanda, Kigali. FAU - Pilesjo, Petter AU - Pilesjo P AD - Lund University, Lund, Sweden. FAU - Mansourian, Ali AU - Mansourian A AD - Department of Earth and Environmental Sciences, Lund University, Lund. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260914 PL - Italy TA - Geospat Health JT - Geospatial health JID - 101302943 SB - IM MH - Humans MH - Rwanda/epidemiology MH - Cross-Sectional Studies MH - Female MH - Infant MH - Male MH - *Body Height MH - Child, Preschool MH - *Growth Disorders/epidemiology MH - *Family Characteristics MH - *Neural Networks, Computer MH - *Spatial Analysis MH - *Spatial Regression OTO - NOTNLM OT - Child height-for-age OT - Rwanda OT - childhood stunting OT - geographically weighted regression OT - spatial heterogeneity EDAT- 2026/09/14 11:40 MHDA- 2026/09/14 11:41 CRDT- 2026/09/14 08:42 PHST- 2026/01/28 00:00 [received] PHST- 2026/03/29 00:00 [accepted] PHST- 2026/09/14 11:41 [medline] PHST- 2026/09/14 11:40 [pubmed] PHST- 2026/09/14 08:42 [entrez] AID - 10.4081/gh.2026.1491 [doi] PST - ppublish SO - Geospat Health. 2026 Jul 23;21(2). doi: 10.4081/gh.2026.1491. Epub 2026 Sep 14. PMID- 42732250 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260913 LR - 20260914 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 9 DP - 2026 Sep TI - Herbal Extracts and Plant-Derived Bioactives in Atopic Dermatitis: Evidence, Mechanisms, Pediatric Safety, and Translational Priorities. PG - e72239 LID - 10.1002/fsn3.72239 [doi] LID - e72239 AB - Atopic dermatitis (AD) is a chronic, relapsing epithelial and neuroimmune disease in which barrier failure, type 2 inflammation, microbial dysbiosis, itching, metabolism, and environmental exposures reinforce one another. This review critically synthesizes clinical and preclinical evidence for herbal medicines, standardized extracts, food-derived bioactives, functional-food candidates, nutraceutical ingredients, and natural-product delivery systems in AD, with particular attention to pediatric safety. Recurrent experimental signals include attenuation of Th2 cytokines and IgE, suppression of mast-cell and IL-31-related itch pathways, restoration of filaggrin and tight-junction proteins, and modulation of MAPK/NF-kappaB, JAK/STAT, Nrf2/HO-1, and NLRP3 signaling. However, efficacy is not inferred from pathway changes alone. Human evidence remains heterogeneous, and apparently promising agents have failed to outperform active comparators, produced neutral microbiome results, or raised barrier and sensitization concerns. We therefore integrate four issues that are often treated separately: food sources and processing-dependent chemistry; oral bioaccessibility and food-matrix effects; gut-skin signaling and its uncertain causal direction; and compatibility with standard topical agents, cyclosporine, biologics, and JAK inhibitors. The evidence supports selected botanicals as investigational adjuncts rather than as replacements for guideline-based care. Translation requires authenticated materials, quantitative chemical fingerprints, exposure-response studies, age-appropriate safety surveillance, interaction assessment, and controlled trials using validated clinical and barrier endpoints. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Zeng, Muhuang AU - Zeng M AUID- ORCID: 0009-0000-1047-3598 AD - Shantou Hospital of Traditional Chinese Medicine Shantou China. FAU - Yuan, Qianlan AU - Yuan Q AD - Sichuan Jinxin Xinan Women and Children Hospital Chengdu China. FAU - Huang, Shuojia AU - Huang S AD - Guangdong Chaozhou Health Vocational College Chaozhou China. FAU - Lu, Xiaofei AU - Lu X AD - Shenzhen Bao'an Chinese Medicine Hospital The Seventh Clinical College of Guangzhou University of Chinese Medicine Shenzhen China. LA - eng PT - Journal Article PT - Review DEP - 20260911 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13569883 OTO - NOTNLM OT - atopic dermatitis OT - dietary bioactives OT - drug delivery OT - functional foods OT - gut-skin axis OT - herbal medicine OT - nutraceuticals OT - pediatric safety COIS- The authors declare no conflicts of interest. EDAT- 2026/09/13 05:41 MHDA- 2026/09/13 05:42 PMCR- 2026/09/11 CRDT- 2026/09/13 04:07 PHST- 2026/06/22 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/09/13 05:42 [medline] PHST- 2026/09/13 05:41 [pubmed] PHST- 2026/09/13 04:07 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - FSN372239 [pii] AID - 10.1002/fsn3.72239 [doi] PST - epublish SO - Food Sci Nutr. 2026 Sep 11;14(9):e72239. doi: 10.1002/fsn3.72239. eCollection 2026 Sep. PMID- 42732148 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260913 LR - 20260914 IS - 2732-5121 (Electronic) IS - 2732-5121 (Linking) VI - 6 DP - 2026 TI - MSCA HOPE - Physical education in hospital schools: A protocol paper for systematic and umbrella reviews with policy framework analysis. PG - 188 LID - 10.12688/openreseurope.23993.2 [doi] LID - 188 AB - Hospital school programs support educational continuity for children and adolescents during hospitalization, but the provision of physical education (PE) remains inconsistent and is rarely addressed by unified standards. This protocol aims to describe the methods for three complementary components designed to synthesise evidence on PE and related movement interventions in hospital settings and to map the policy frameworks governing PE provision in hospital schools. Tier 1 is an umbrella review of existing systematic reviews on physical activity interventions for hospitalised youth. Tier 2 is a systematic review of primary studies examining PE in hospital-school settings. For Tier 2, PE is operationally defined as a planned movement-based learning experience with an explicit educational purpose that is formally integrated into the hospital-school program or involves educational staff in its planning, delivery or assessment. Therapeutic exercise, rehabilitation and active play without this educational connection will be excluded from Tier 2, although they may be represented in Tier 1. A parallel policy framework analysis will identify and compare relevant laws, regulations, curricula, strategies and guidelines. Separate search strategies will be used for each component across health, education, sport and policy sources, without language or date restrictions. Narrative synthesis will be the primary approach. Meta-analysis will be considered only when at least three independent studies are sufficiently comparable in population, intervention, design, outcome construct and assessment time point. Priority synthesis will distinguish implementation/process evidence from effectiveness outcomes. Safety, implementation and educational participation will be synthesised primarily using narrative, qualitative and mixed-method approaches, whereas physical functioning and psychosocial well-being will be prioritised for quantitative effect synthesis and Grading of Recommendations Assessment, Development and Evaluation (GRADE) when sufficiently comparable evidence is available. The planned reviews are intended to clarify the available evidence and policy landscape and may inform subsequent guideline development for PE in hospital schools. PROSPERO registration: CRD420251156215. CI - Copyright: (c) 2026 Ciaccioni S et al. FAU - Ciaccioni, Simone AU - Ciaccioni S AUID- ORCID: 0000-0001-9533-9178 AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy, 00135, Italy. FAU - Pesce, Caterina AU - Pesce C AD - Department of Kinesiology, Michigan State University, East Lansing, MI, 48824, USA. FAU - Benzing, Valentin AU - Benzing V AD - Institute of Sport Science, Department of Sport Pedagogy, University of Bern, Bern, 3012, Switzerland. FAU - Schmidt, Mirko AU - Schmidt M AD - Institute of Sport Science, Department of Sport Pedagogy, University of Bern, Bern, 3012, Switzerland. FAU - Magalhaes, Paula AU - Magalhaes P AD - School of Psychology, University of Minho, Braga, 4710-057, Portugal. FAU - Rosario, Pedro AU - Rosario P AD - School of Psychology, University of Minho, Braga, 4710-057, Portugal. FAU - Pedrosa Leal, Luciana AU - Pedrosa Leal L AD - Department of Nursing, Federal University of Pernambuco, Recife, PE, 50670-420, Brazil. FAU - Pontes, Cleide Maria AU - Pontes CM AD - Department of Nursing, Federal University of Pernambuco, Recife, PE, 50670-420, Brazil. FAU - Oddi, Livia AU - Oddi L AUID- ORCID: 0009-0004-0658-5270 AD - Department of Information Engineering, Control and Management, Sapienza University of Rome, Rome, 00185, Italy. FAU - Betello, Filippo AU - Betello F AD - Department of Computer, Control and Management Engineering, Sapienza University of Rome, Rome, 00185, Italy. FAU - Bradic, Slavisa AU - Bradic S AD - International Judo Federation Academy Foundation, Malta, XBX 1421, Malta. FAU - Capranica, Laura AU - Capranica L AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy, 00135, Italy. LA - eng PT - Journal Article DEP - 20260827 PL - Belgium TA - Open Res Eur JT - Open research Europe JID - 9918230081006676 PMC - PMC13562943 OAB - Children and adolescents who spend time in hospital often continue their education through hospital school programmes. These programmes help them stay connected with learning, teachers, and classmates. However, physical education is not always included. This is important because movement, play, exercise, and physical education can support children's physical health, emotional wellbeing, social participation, and learning. In hospital settings, however, physical education can be difficult to organise. Children may have different health conditions, energy levels, treatment schedules, and safety needs. Hospitals and schools may also follow different rules, and there are no shared standards to guide practice. This study will bring together the best available knowledge on physical education and physical activity for children and adolescents in hospital settings. The researchers will review previous research studies and examine existing policies and guidelines from different countries and organisations. They will look at what has been studied, what seems helpful, what evidence is still missing, and what rules or recommendations already exist. The study will consider outcomes related to physical health, mental and social wellbeing, learning, clinical conditions, and practical delivery. It will also assess how reliable the available evidence is. The results will help build a clearer evidence base for future guidance on physical education in hospital schools. The long-term aim is to support teachers, healthcare professionals, schools, families, and policymakers in offering safe, meaningful, and inclusive physical education opportunities for children and adolescents during hospitalisation. This review protocol is registered in PROSPERO: CRD420251156215. OABL- eng OTO - NOTNLM OT - barriers and facilitators OT - evidence-informed policy. OT - health-education integration OT - hospitalised youth OT - interprofessional collaboration OT - physical activity programs OT - sport science OT - systematic literature review COIS- No competing interests were disclosed. EDAT- 2026/09/13 05:41 MHDA- 2026/09/13 05:42 PMCR- 2026/08/27 CRDT- 2026/09/13 03:53 PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/13 05:42 [medline] PHST- 2026/09/13 05:41 [pubmed] PHST- 2026/09/13 03:53 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.12688/openreseurope.23993.2 [doi] PST - epublish SO - Open Res Eur. 2026 Aug 27;6:188. doi: 10.12688/openreseurope.23993.2. eCollection 2026. PMID- 42731058 OWN - NLM STAT- Publisher LR - 20260912 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Sep 12 TI - Does the British Columbia Farmers' Market Nutrition Coupon Program improve the diet quality and food security of parents and children with lower incomes? Protocol for a dose-response, pragmatic randomized controlled trial. PG - 2601060261473062 LID - 10.1177/02601060261473062 [doi] AB - BackgroundThe British Columbia Farmers' Market Nutrition Coupon Program (FMNCP) provides lower-income households with coupons to purchase healthy foods at farmers' markets.AimThis pragmatic randomized controlled trial (RCT) will examine the effectiveness and cost-effectiveness of two higher subsidies for healthy food, compared to the usual FMNCP healthy food subsidy, on the diet quality (primary outcome), food insecurity, and other health-related outcomes of 276 parent-child dyads with lower incomes.MethodsIn this single-blind, three-arm, parallel-group pragmatic RCT, 276 parent-child dyads in lower-income households will be randomized to receive the usual FMNCP healthy food subsidy ($27/week) or a subsidy that is two ($54/week) or three times ($81/week) higher. Participants will receive 16 weeks of coupons that can be redeemed for up to 20 weeks. Outcomes will be assessed in one parent (18-64 years) and child (6-17 years) from each household pre-, mid-, and post-intervention. Dietary intake will be collected via two 24-h dietary recalls at each time point to calculate diet quality using the Healthy Eating Food Index-2019. Food insecurity and other health-related outcomes will be assessed using validated self-reported instruments. Mixed effects regression will assess the effects of the interventions, relative to the usual subsidy, on outcomes in parents and children. A full incremental analysis will quantify the cost-effectiveness ratios of the healthy food subsidies.SummaryThis dose-response RCT will show how the diet quality, food insecurity, and other health-related outcomes of parents and children vary according to subsidy amount.Trial registrationThe trial is registered at www.clinicaltrials.gov (NCT06992947). FAU - Olstad, Dana Lee AU - Olstad DL AUID- ORCID: 0000-0001-9787-9952 AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Campbell, David Jt AU - Campbell DJ AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 AD - Department of Medicine, Cumming School of Medicine, University of Calgary Foothills Medical Centre-North Tower, Calgary, AB, Canada. AD - Department of Cardiac Sciences, Cumming School of Medicine, Calgary, AB, Canada. FAU - Sajobi, Tolulope T AU - Sajobi TT AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - O'Hara, Heather AU - O'Hara H AD - British Columbia Association of Farmers' Markets, Vancouver, BC, Canada. RINGGOLD: 576770 FAU - Leblanc, Peter AU - Leblanc P AD - British Columbia Association of Farmers' Markets, Vancouver, BC, Canada. RINGGOLD: 576770 FAU - McCormack, Gavin R AU - McCormack GR AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Radin-Pereira, Leticia AU - Radin-Pereira L AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Lee, Yun Yun AU - Lee YY AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Aktary, Michelle L AU - Aktary ML AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Minaker, Leia M AU - Minaker LM AD - Future Cities Institute, School of Planning, University of Waterloo, Waterloo, ON, Canada. RINGGOLD: 8430 FAU - Spackman, Eldon AU - Spackman E AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 LA - eng SI - ClinicalTrials.gov/NCT06992947 PT - Journal Article DEP - 20260912 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Randomized controlled trial OT - adults OT - children OT - diet quality OT - dose-response OT - farmers' market OT - food insecurity OT - healthy food subsidy OT - lower-income OT - parental shielding EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:50 CRDT- 2026/09/12 13:03 PHST- 2026/09/13 00:50 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 13:03 [entrez] AID - 10.1177/02601060261473062 [doi] PST - aheadofprint SO - Nutr Health. 2026 Sep 12:2601060261473062. doi: 10.1177/02601060261473062. PMID- 42730926 OWN - NLM STAT- Publisher LR - 20260912 IS - 1432-1998 (Electronic) IS - 0301-0449 (Linking) DP - 2026 Sep 12 TI - Musculoskeletal ultrasonography of lower extremity entheses in children and adolescents - a pilot study of normal B-mode and Doppler characteristics. LID - 10.1007/s00247-026-06784-y [doi] AB - BACKGROUND: Musculoskeletal ultrasonography is an important imaging modality in children. Features of arthritis are well defined and age-related normative data exist. Data on entheses are limited with no consensus on definition of pathology. OBJECTIVES: The aim of this pilot study was to evaluate entheseal thickness, echotexture, and presence of vascularity in healthy children and adolescents as a prerequisite for distinction from pathology. MATERIALS AND METHODS: Children and adolescents without musculoskeletal conditions underwent standardized B-mode and power Doppler ultrasonography of the dominant hip, knee, and ankle entheses. Entheseal thickness, echotexture, and vascularity were assessed, alongside demographic, puberty, and physical activity data. Statistical analysis included intraclass correlation coefficients, single regression, and t-tests. RESULTS: Seventy-nine healthy participants (mean age 10.5 years; 48% female) were included. All 782 evaluated entheses showed normal B-mode echotexture. Inter- and intraobserver reliability was high to excellent, with intraclass correlation coefficient values ranging from 0.84-0.99 and 0.91-0.99, respectively. Entheseal thickness correlated significantly with age (r = 0.65-0.90), lacking sex-specific differences at most sites. Minor power Doppler activity was detected in 1-44% of entheses within 2 mm of the insertion, increasing to 2-68% within 5 mm. Doppler signals were most frequent at proximal sartorius and knee entheses. CONCLUSION: Entheseal thickness correlates with age, but sex differences are minimal. Mild signals are common at the sartorius, quadriceps, and Achilles entheses with normal B-mode findings. Pathologic Doppler may require accompanying B-mode abnormalities. These data broaden the base for ultrasonography of pediatric entheses and facilitate differentiation of pathology from normal findings. CI - (c) 2026. The Author(s). FAU - Hansmann, Sandra AU - Hansmann S AUID- ORCID: 0000-0002-7486-3090 AD - Department of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology and Social Pediatrics, University Children's Hospital Tubingen, Tubingen, Hoppe-Seyler-Str. 1, 72076 Tubingen, Germany. sandra.hansmann@klinikum.uni-tuebingen.de. FAU - Roth, Johannes AU - Roth J AD - Childrens's Hospital of Central Switzerland, University of Lucerne, Lucerne, Switzerland. LA - eng PT - Journal Article DEP - 20260912 PL - Germany TA - Pediatr Radiol JT - Pediatric radiology JID - 0365332 SB - IM OTO - NOTNLM OT - Doppler OT - Enthesis OT - Healthy children OT - Lower extremity OT - Pediatric rheumatology OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: The study was approved by the local Ethics Committee of the University of Tubingen (No. 721/2019BO1, approval June 10, 2020) and adhered to the Declaration of Helsinki. Written informed consent was obtained from all participants and their legal guardians. Conflicts of interest: None EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:50 CRDT- 2026/09/12 11:14 PHST- 2026/05/07 00:00 [received] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/09/01 00:00 [revised] PHST- 2026/09/13 00:50 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 11:14 [entrez] AID - 10.1007/s00247-026-06784-y [pii] AID - 10.1007/s00247-026-06784-y [doi] PST - aheadofprint SO - Pediatr Radiol. 2026 Sep 12. doi: 10.1007/s00247-026-06784-y. PMID- 42730602 OWN - NLM STAT- Publisher LR - 20260921 IS - 1365-2516 (Electronic) IS - 1351-8216 (Linking) DP - 2026 Sep 12 TI - Living With Factor VII Deficiency-A Mixed Methods Study. LID - 10.1111/hae.70404 [doi] AB - BACKGROUND: Factor VII deficiency (FVIID) is a rare autosomal recessive disorder, resulting in potentially unpredictable and life-threatening bleeding. The prevalence of symptomatic patients is 1 in 300,000. Treatment is mostly given following bleeding, but those with the lowest levels may be offered prophylaxis. OBJECTIVES: We aimed to explore the real-life impact of FVIID on individuals and their families, focusing on psychosocial wellbeing and quality of life (QoL). METHODS: The study used a quantitative survey, including validated QoL tools, and qualitative one-to-one interviews to enable deeper exploration of the quantitative findings. RESULTS: One hundred people with FVIID (74 adults; 26 caregivers of children) completed the survey; 24 (18 adults; 6 caregivers) were interviewed. A significant gender-based disparity was observed: males were diagnosed at a median age of 4 years, versus 17 years in females (p < 0.001). 56% of respondents reported a mean of 1.25 bleeds per week; significantly higher in women than men (mean 1.65 vs. 0.53/week, respectively; p < 0.01). QoL scores decreased with increased bleeding measured by the self-BAT (p < 0.001). Bleeding was associated with significant social impact: missed physical activity (64%), avoidance of social engagements (53%) and lost education (50%). Interviews yielded six core themes associated with unmet need. CONCLUSION: FVIID causes significant challenges, disproportionately borne by women and compounded by gaps in management, especially treatment. Current treatments are burdensome and fail to prevent breakthrough bleeds. People with FVIID have unmet needs that require therapeutic innovation, improved diagnosis and management strategies, and data collection to improve their QoL and outcomes. CI - (c) 2026 The Author(s). Haemophilia published by John Wiley & Sons Ltd. FAU - Fletcher, Simon AU - Fletcher S AD - Haemnet Ltd, London, UK. FAU - Boyton, Matthew AU - Boyton M AD - Haemnet Ltd, London, UK. FAU - Bristow, Sam AU - Bristow S AD - Haemnet Ltd, London, UK. FAU - Khair, Kate AU - Khair K AD - Haemnet Ltd, London, UK. LA - eng GR - Hemab Therapeutics/ PT - Journal Article DEP - 20260912 PL - England TA - Haemophilia JT - Haemophilia : the official journal of the World Federation of Hemophilia JID - 9442916 SB - IM OTO - NOTNLM OT - factor VII deficiency OT - mixed methods OT - natural history OT - quality of life OT - unmet need EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:50 CRDT- 2026/09/12 08:23 PHST- 2026/08/31 00:00 [revised] PHST- 2026/05/27 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/13 00:50 [medline] PHST- 2026/09/12 08:23 [entrez] AID - 10.1111/hae.70404 [doi] PST - aheadofprint SO - Haemophilia. 2026 Sep 12. doi: 10.1111/hae.70404. PMID- 42730388 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Academic- and Family-Related Correlates of Anxiety Among College-Going Adolescents in Central India: A Cross-Sectional Study. PG - e114386 LID - 10.7759/cureus.114386 [doi] LID - e114386 AB - BACKGROUND: Anxiety is the most common mental health disorder among adolescents worldwide. In India, intense academic competition and evolving family dynamics add to this burden, yet systematic data from smaller central Indian districts are scarce. OBJECTIVE: This study aims to determine the prevalence and severity of anxiety among college-going adolescents aged 17-19 years in Ratlam district, Madhya Pradesh, and to examine its association with academic- and family-related factors. METHODS: In this cross-sectional observational study, 550 first-year students were enrolled from 10 colleges (five professional, five nonprofessional) through multistage random sampling between June 2023 and November 2024. Depression, anxiety, and stress were measured with the validated Depression Anxiety Stress Scale-21 (DASS-21). Family-related factors included family type, parental marital status, sibling count, and paternal education, while academic-related factors included college type. Associations were assessed with the chi-square test and Cramer's V, and factors independently associated with clinically significant anxiety were assessed using binary logistic regression, yielding adjusted odds ratios (AORs) with 95% confidence intervals (CIs), using R (version 4.3); p < 0.05 was considered significant. RESULTS: Clinically significant anxiety was recorded in 178 participants (32.36%) (mild: 110 (20.00%); moderate: 57 (10.36%); severe: 11 (2.00%)), making anxiety the most prevalent DASS-21 domain ahead of stress (116; 21.09%) and depression (62; 11.28%). On multivariable analysis, female sex (AOR: 2.26; 95% CI: 1.45-3.52; p < 0.001), professional-college enrolment (AOR: 1.45; 95% CI: 1.05-2.01; p = 0.024), and hostel residence (AOR: 1.68; 95% CI: 1.15-2.45; p = 0.007) were independently associated with higher odds of clinically significant anxiety, whereas joint-family structure was associated with lower odds (AOR: 0.62; 95% CI: 0.42-0.91; p = 0.015). Nuclear-family students showed the highest anxiety prevalence (113 of 301; 37.54%) compared with joint-family students (59 of 230; 25.70%). Music (226; 41.09%) and social connection (95; 17.27%) were the most frequently used coping strategies, whereas physical exercise was rarely used (8; 1.45%). CONCLUSIONS: Academic- and family-related factors were associated with anxiety among college-going adolescents. These findings support the need for campus-based mental-health screening, accessible counselling services, and promotion of healthy coping strategies, including physical activity. CI - Copyright (c) 2026, Chawla et al. FAU - Chawla, Heena AU - Chawla H AD - Community Medicine, Dr. Laxminarayan Pandey Government Medical College, Ratlam, IND. FAU - Sinha, Umesh AU - Sinha U AD - Community Medicine, Dr. Laxminarayan Pandey Government Medical College, Ratlam, IND. FAU - Agriya, Rajkumar AU - Agriya R AD - Community Medicine, Dr. Laxminarayan Pandey Government Medical College, Ratlam, IND. FAU - Ranasaria, Hitesh AU - Ranasaria H AD - Orthopedics, Virendra Kumar Sakhlecha Government Medical College, Neemuch, IND. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13566112 OTO - NOTNLM OT - academic factors OT - adolescent anxiety OT - college students OT - cross-sectional study OT - dass-21 OT - family factors OT - mental health COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Government Autonomous Medical College, Ratlam issued approval GMC/RATLAM/2023/IEC/Approval/09. The institutional ethics committee meeting held on 27.05.2023 and 28.05.2023 approved the research project entitled "Assessment of Mental Well-being and its correlates in college-going adolescents (17-19 years) of Ratlam District. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/11 CRDT- 2026/09/12 08:04 PHST- 2026/08/11 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 08:04 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 10.7759/cureus.114386 [doi] PST - epublish SO - Cureus. 2026 Aug 11;18(8):e114386. doi: 10.7759/cureus.114386. eCollection 2026 Aug. PMID- 42729466 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 2451-8654 (Electronic) IS - 2451-8654 (Linking) VI - 53 DP - 2026 Oct TI - From Kitchen to Clinic: Study protocol for a family-centered, food-as-medicine approach using medically tailored meals and caregiver coaching in pediatric oncology care. PG - 101681 LID - 10.1016/j.conctc.2026.101681 [doi] LID - 101681 AB - BACKGROUND: Children undergoing cancer treatment are at high risk for malnutrition, poor diet quality, and early cardiometabolic risk due to treatment-related side effects, disrupted appetite, and household-level barriers to healthy eating. Caregivers play a central role in nutritional support during treatment but often experience substantial burden, time constraints, and nutrition insecurity. Food-as-medicine strategies, including medically tailored meals (MTMs), have shown promise in adult populations but remain underexplored in pediatric oncology, particularly during active treatment and within family-centered models. OBJECTIVE: The primary objective of this study is to evaluate the feasibility, acceptability, and adherence of From Kitchen to Clinic, a 12-week, family-centered food-as-medicine intervention that integrates MTM delivery with caregiver coaching for caregivers of children undergoing cancer treatment. Secondary objectives include collecting exploratory data on patient dietary intake, weight and lean body mass trajectories, treatment tolerance, household food and nutrition security, and caregiver burden and distress to inform a future definitive trial. METHODS: This prospective, single-arm feasibility study will enroll 60 caregiver-child dyads (N = 120) recruited from three outpatient pediatric oncology clinics at a large children's hospital. The 12-week intervention includes an intensive phase (weeks 1-8) with weekly MTM delivery and caregiver coaching, followed by a tapered phase (weeks 9-12) with reduced meal frequency and bi-weekly coaching. Feasibility outcomes include recruitment, retention, assessment completion, intervention adherence, and acceptability, evaluated against predefined progression criteria. Exploratory outcomes will be assessed at baseline and at 3, 6, and 12 months post-intervention using validated dietary, anthropometric, clinical, and caregiver-reported measures. TRIAL REGISTRATION: NCT07454902. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Milliron, Brandy-Joe AU - Milliron BJ AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Schlechter, Haley AU - Schlechter H AD - Children's Hospital of Philadelphia, King of Prussia, PA, USA. FAU - Muir, Cass AU - Muir C AD - The Center for Childhood Cancer Research, Supportive Care in Oncology Research (SCORe) Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Moss, Cynthia AU - Moss C AD - The Center for Childhood Cancer Research, Supportive Care in Oncology Research (SCORe) Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Henstenburg, Jule Anne AU - Henstenburg JA AD - MANNA Institute, Metropolitan Area Neighborhood Nutrition Alliance, Philadelphia, PA, USA. FAU - Rappaport, Kylee AU - Rappaport K AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Boakye, Faustina AU - Boakye F AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Deutsch, Jonathan M AU - Deutsch JM AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Jubelirer, Tracey AU - Jubelirer T AD - Department of Pediatrics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. AD - Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. LA - eng SI - ClinicalTrials.gov/NCT07454902 PT - Journal Article DEP - 20260829 PL - Netherlands TA - Contemp Clin Trials Commun JT - Contemporary clinical trials communications JID - 101671157 PMC - PMC13562409 OTO - NOTNLM OT - Caregiving OT - Feasibility OT - Food as medicine OT - Medically tailored meals OT - Nutrition OT - Pediatric oncology OT - Survivorship COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/29 CRDT- 2026/09/12 06:51 PHST- 2026/03/18 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 06:51 [entrez] PHST- 2026/08/29 00:00 [pmc-release] AID - S2451-8654(26)00088-8 [pii] AID - 101681 [pii] AID - 10.1016/j.conctc.2026.101681 [doi] PST - epublish SO - Contemp Clin Trials Commun. 2026 Aug 29;53:101681. doi: 10.1016/j.conctc.2026.101681. eCollection 2026 Oct. PMID- 42728946 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 2633-4402 (Electronic) IS - 2633-4402 (Linking) VI - 5 DP - 2025 TI - Adapt-Ed: co-designing adaptations to a whole school intervention to improve the uptake and impact of food provision in special schools - scoping research for a future trial. PG - 50 LID - 10.3310/nihropenres.13897.2 [doi] LID - 50 AB - BACKGROUND: Children and young people (CYP) with Special Educational Needs and/or Disabilities (SEND) are more likely to grow up in poverty and be entitled to free school meals than other children. However, they might not eat well at school because their needs aren't always accommodated. There is a need to understand school food provision for children with SEND and how the whole school food environment (WSFE) can be improved to address health inequalities. METHODS: We conducted scoping research and involved public and professional stakeholders in co-producing adaptations to a whole school food approach called Healthy Zones (HZ). The aim was to inform a future proposal to implement and evaluate the Adapt-ed HZ intervention in special schools. The four work packages (WP) (June to November 2024) were: WP1: establish stakeholder groups to co-produce a logic model and HZ adaptations; WP2: scoping reviews of food interventions for CYP with SEND; WP3: analysis of publicly available administrative data and online survey; WP4: ethnographic case studies of three special schools. RESULTS: Working with CYP with SEND, parents, carers and professionals in schools and policy roles, Adapt-Ed has provided a wealth of information to tailor and refine the HZ approach for special schools. It has included extensive public involvement and scoping research to inform future research. The work has led to a draft logic model and outline research plan which have been co-produced with public and professional stakeholders throughout. CONCLUSION: Through this project we have co-produced HZ adaptations and a draft logic model and learned there is a need and demand for Adapt-Ed HZ to enhance WSFEs in special schools and promote children's health and wellbeing. Subject to a feasibility study to refine the research protocol and test data collection methods, a trial is recommended to implement and evaluate the effect of Adapt-Ed HZ on the health and wellbeing of children with SEND. CI - Copyright: (c) 2026 O'Connell R et al. FAU - O'Connell, Rebecca AU - O'Connell R AUID- ORCID: 0000-0003-1515-2659 AD - University of Hertfordshire, Hatfield, England, UK. FAU - Ludlow, Amanda AU - Ludlow A AD - University of Hertfordshire, Hatfield, England, UK. FAU - Holford, Angus AU - Holford A AUID- ORCID: 0000-0003-2019-4845 AD - University of Essex, Colchester, England, UK. FAU - Hamilton, Laura AU - Hamilton L AUID- ORCID: 0000-0002-2388-3278 AD - University of Hertfordshire, Hatfield, England, UK. FAU - Brady, Louca-Mai AU - Brady LM AD - University of Hertfordshire, Hatfield, England, UK. FAU - Denyer, Lauren AU - Denyer L AUID- ORCID: 0009-0009-6423-9663 AD - University of Hertfordshire, Hatfield, England, UK. FAU - Feltham, Andy AU - Feltham A AD - University of Hertfordshire, Hatfield, England, UK. FAU - Wellsted, David AU - Wellsted D AD - University of Hertfordshire, Hatfield, England, UK. LA - eng PT - Journal Article DEP - 20260801 PL - England TA - NIHR Open Res JT - NIHR open research JID - 9918333281906676 PMC - PMC13560602 OAB - Why are we doing this project? Eating nutritious food at school can create more equality in the diets and lives of children from lower and higher income families. However, children with special educational needs and/or disabilities (SEND) might not be able to eat well at school because their needs aren't always accommodated. Schools can have an influence on children's eating habits, including education and activities outside school. Making learning about and eating nutritious food part of all aspects of the school day is known as a 'whole school approach'. This approach can increase the number of children who eat school dinners and improve their health and wellbeing. We wanted to explore how a 'whole school approach' called Healthy Zones might work in special schools. What have we done so far? We involved children and young people, their caregivers, and people who work in or for schools in our plans. This helped us to create an idea of what the approach needs to grow and have good outcomes. We reviewed past research to identify ways to measure nutritious eating for children with SEND. This helped us discover that there are not enough ways to measure nutritious eating for children with SEND. We explored existing information on free school meals and found out that children with SEND are more likely to be eligible for free school meals, but less likely to have one in some schools. We worked with three special schools in the East of England to find out how taking part in future research would work for them. This helped us identify the opportunities and practicalities of trying out a whole school approach in future research. What is next? We will use what we've learned to apply for a new project to test our Adapt-Ed Healthy Zones in special schools. OABL- eng OTO - NOTNLM OT - School food OT - children and young people OT - co-production OT - health inequalities OT - mixed methods OT - special educational needs and disabilities OT - whole school food environments COIS- Competing interests: From 2019-2026 RO'C was a voluntary trustee / Chair of Trustees, of the charity School Food Matters (SFM). SFM exists to teach children about food and to improve children's access to healthy, sustainable food during their time at school. SFM delivers the Healthy Zones programme and is a collaborator on the Application Development Award underpinning this work. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/01 CRDT- 2026/09/12 05:55 PHST- 2026/07/22 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 05:55 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 10.3310/nihropenres.13897.2 [doi] PST - epublish SO - NIHR Open Res. 2026 Aug 1;5:50. doi: 10.3310/nihropenres.13897.2. eCollection 2025. PMID- 42728700 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261022 IS - 1439-4286 (Electronic) IS - 0018-5043 (Linking) VI - 58 IP - 10 DP - 2026 Oct TI - Association of Progesterone and Prolactin with Hepatic Steatosis in Premenopausal Women: A Prospective Cross-Sectional Study. PG - 413-418 LID - 10.1055/a-2949-7994 [doi] AB - This study aimed to investigate the association between hepatic steatosis and serum levels of reproductive hormones in premenopausal women, with particular focus on progesterone and prolactin. A total of 87 premenopausal women aged 18-45 years were included in this prospective study. Participants were classified by ultrasonographic steatosis status and grade. Blood samples obtained on day 3 of the menstrual cycle were used to measure follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, and prolactin levels. Women with overt metabolic and endocrine disorders were excluded. Multivariable logistic regression and receiver operating characteristic analyses were performed. Hepatic steatosis was present in 53 participants (60.9%), whereas 34 participants had no steatosis. Progesterone and prolactin levels were significantly lower in participants with hepatic steatosis than in those without steatosis (0.6 vs. 1.1 ng/mL and 7.9 vs. 11.0 ng/mL, respectively; both p<0.001). In multivariable analysis, older age (odds ratio: 1.32, 95% confidence interval: 1.12-1.56; p=0.001), higher body mass index (odds ratio: 1.57, 95% confidence interval: 1.19-2.08; p=0.002), lower progesterone levels (odds ratio: 0.75, 95% confidence interval: 0.58-0.98; p=0.037), and lower prolactin levels (odds ratio: 0.51, 95% confidence interval: 0.34-0.79; p=0.002) were independently associated with hepatic steatosis. Estradiol, follicle-stimulating hormone, and luteinizing hormone were not associated with steatosis. Receiver operating characteristic analysis showed a discriminative value for progesterone (area under the curve: 0.751) and prolactin (area under the curve: 0.790). Lower serum progesterone and prolactin levels were associated with hepatic steatosis after adjustment for age and body mass index. These findings support a possible relationship between reproductive hormonal milieu and hepatic steatosis in a selected premenopausal population, while the progesterone finding should be interpreted in the context of early follicular-phase measurement. CI - Thieme. All rights reserved. FAU - Ulusoy, Muhammed Aziz AU - Ulusoy MA AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Comoglu, Mustafa AU - Comoglu M AUID- ORCID: 0000-0003-4977-9919 AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Zengin, Oguzhan AU - Zengin O AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Camli, Huseyin AU - Camli H AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Uzdogan, Esma Andac AU - Uzdogan EA AD - Ministry of Health Ankara Bilkent City Hospital, Department of Medical Biochemistry, Ankara, Turkey, Cankaya. FAU - Kalkan, Emra Asfuroglu AU - Kalkan EA AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Ates, Ihsan AU - Ates I AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. LA - eng PT - Journal Article DEP - 20260911 PL - Germany TA - Horm Metab Res JT - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JID - 0177722 RN - 9002-62-4 (Prolactin) RN - 4G7DS2Q64Y (Progesterone) RN - 9002-68-0 (Follicle Stimulating Hormone) SB - IM MH - Humans MH - Female MH - *Prolactin/blood MH - *Progesterone/blood MH - Adult MH - *Premenopause/blood MH - Prospective Studies MH - *Fatty Liver/blood MH - Cross-Sectional Studies MH - Middle Aged MH - Young Adult MH - Adolescent MH - Follicle Stimulating Hormone/blood MH - ROC Curve COIS- The authors declare that they have no conflict of interest. EDAT- 2026/09/13 00:50 MHDA- 2026/10/22 23:28 CRDT- 2026/09/12 05:33 PHST- 2026/10/22 23:28 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 05:33 [entrez] AID - 10.1055/a-2949-7994 [doi] PST - ppublish SO - Horm Metab Res. 2026 Oct;58(10):413-418. doi: 10.1055/a-2949-7994. Epub 2026 Sep 11. PMID- 42728638 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 1758-5996 (Print) IS - 1758-5996 (Electronic) IS - 1758-5996 (Linking) VI - 18 IP - 1 DP - 2026 Aug 4 TI - Unpacking adiposity: a narrative critical appraisal of diverse obesity definitions. LID - 10.1186/s13098-026-02261-6 [doi] LID - 201 AB - BACKGROUND: Obesity is a complex, multifaceted chronic disease that poses a major global health challenge. Traditionally, population-level screening and follow-up have relied heavily on body mass index (BMI). Although BMI provides a simple, standardized measure for epidemiological studies, it does not account for individual variations in muscle mass, fat distribution, or metabolic health. Consequently, relying solely on weight-to-height ratios-even when supplemented with waist circumference, waist-to-hip ratio, or waist-to-height ratio-limits precise individual diagnosis and comprehensive health risk assessment. Comprehensive risk stratification incorporating clinical factors beyond body weight is therefore needed to capture the heterogeneity of obesity and enable a more individualized, patient-centered approach to management. MAIN BODY: This critical narrative review evaluates the main definitions and classification systems used for obesity, including the traditional World Health Organization classification, the Edmonton Obesity Staging System (EOSS), the Lancet Commission framework, the European Association for the Study of Obesity framework, and classifications based on weight history. BMI remains valuable for population-level assessment and may also be useful at the individual level when combined with additional anthropometric measurements and sex-, age-, and ethnicity-specific cutoff values. The EOSS complements anthropometric assessment by incorporating metabolic, physical, psychological, and functional consequences, thereby supporting treatment intensity according to disease severity. The Lancet Commission definitions of preclinical and clinical obesity broaden diagnosis beyond BMI but have raised concerns regarding the absence of standardized screening tools, potential diagnostic inconsistency, and possible delays in treatment for people classified as having preclinical obesity. Such limitations may be particularly relevant for children and adolescents, in whom delayed intervention may increase long-term health risks. Weight-history classifications provide an additional perspective by incorporating maximum weight attained in life, supporting realistic treatment goals, reinforcing the chronic nature of obesity, reducing stigma, and encouraging long-term treatment adherence. CONCLUSION: No single classification adequately captures the biological and clinical heterogeneity of obesity. BMI should not be abandoned, but interpreted alongside anthropometric, metabolic, functional, psychological, and weight-history information. Integrating complementary classification systems may improve diagnostic accuracy, risk stratification, treatment prioritization, and patient-centered obesity care. CI - (c) 2026. The Author(s). FAU - Mancini, Marcio C AU - Mancini MC AD - Department of Endocrinology, Universidade de Sao Paulo, Sao Paulo, Brazil. mmancini@usp.br. FAU - Halpern, Bruno AU - Halpern B AD - Associacao Brasileira para o Estudo da Obesidade e Sindrome Metabolica, Sao Paulo, Brazil. FAU - de Melo, Maria Edna AU - de Melo ME AD - Department of Endocrinology, Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Associacao Brasileira para o Estudo da Obesidade e Sindrome Metabolica, Sao Paulo, Brazil. FAU - Kramer, Caroline K AU - Kramer CK AD - University of Toronto, Sinai Centre for Diabetes at Mount Sinai Hospital, Toronto, Canada. LA - eng PT - Journal Article PT - Review DEP - 20260804 PL - England TA - Diabetol Metab Syndr JT - Diabetology & metabolic syndrome JID - 101488958 PMC - PMC13563844 OTO - NOTNLM OT - Adipose tissue dysfunction OT - Body mass index OT - Clinical obesity OT - Controlled obesity OT - Diet quality OT - Immunometabolism OT - Metabolic syndrome OT - Reduced obesity OT - Type 2 diabetes OT - Waist circumference COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: MCM has been on speakers' bureaus for Eli-Lilly, Boehringer Ingelheim, Novo Nordisk, Merck, EMS; has received support for attending meetings and/or traveling from Novo Nordisk and Eurofarma; has participated on advisory boards for Novo Nordisk, Eli-Lilly and Ache, Eli-Lilly, Merck, NC Pharma, Brace Pharma, Boehringer Ingelheim. BH has been on a speakers' bureau for Novo Nordisk, Eli-Lilly, Boehringer Ingelheim, Astra Zeneca, Merck; has received support for attending meetings and/or travel from Novo Nordisk; has participated on advisory boards for Novo Nordisk, Eli-Lilly, Merck, Currax, Abbott Nutrition. MEM has been on speakers' bureaus for EMS, Novo Nordisk, Merck; has received support for attending meetings and/or traveling from Novo Nordisk and Eurofarma; has participated on advisory boards for Brace Pharma. CKK has received investigator-initiated research grant from Boehringer Ingelheim not related to this work. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/04 CRDT- 2026/09/12 05:30 PHST- 2026/06/01 00:00 [received] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 05:30 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.1186/s13098-026-02261-6 [pii] AID - 2261 [pii] AID - 10.1186/s13098-026-02261-6 [doi] PST - epublish SO - Diabetol Metab Syndr. 2026 Aug 4;18(1):201. doi: 10.1186/s13098-026-02261-6. PMID- 42728571 OWN - NLM STAT- MEDLINE DCOM- 20260912 LR - 20260915 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Sep 11 TI - New predictive regression models for estimating the size of unerupted canines and premolars in the Egyptian population. LID - 10.1186/s12903-026-09706-4 [doi] LID - 1710 AB - BACKGROUND: Mixed dentition space analysis assesses the discrepancy between the available and required space within the dental arches during the mixed dentition stage, thereby facilitating the diagnosis and treatment planning of developing malocclusions. So, this study aimed to develop Egyptian population-specific regression equations for predicting the combined mesiodistal widths of permanent canines and premolars (Sigma345) and to compare their predictive accuracy with that of the Tanaka and Johnston method. METHODS AND MATERIALS: A retrospective cross-sectional study was conducted on 450 dental casts obtained from Egyptian adolescents aged 13-17 years (230 females and 220 males). The mesiodistal crown widths of the maxillary and mandibular permanent incisors, canines, and premolars were measured using a calibrated digital caliper. Multiple linear regression analysis was performed to develop new prediction equations. The predicted widths obtained using the newly developed equations and the Tanaka and Johnston method were compared with the actual tooth measurements. RESULTS: The mesiodistal widths of the maxillary and mandibular central and lateral incisors demonstrated the strongest correlations with the combined widths of permanent canines and premolars and were therefore used to generate the prediction equations. The newly developed Egyptian equations demonstrated good predictive performance, with coefficients of determination of R(2) = 0.672 for the maxillary arch and R(2) = 0.602 for the mandibular arch. Furthermore, they showed smaller mean prediction errors (0.00 +/- 1.03 mm and 0.00 +/- 1.34 mm for the maxillary and mandibular arches, respectively) than the Tanaka and Johnston equations (- 1.02 +/- 1.22 mm and - 1.30 +/- 1.45 mm, respectively). CONCLUSION: The newly developed Egyptian-specific regression equations provided more accurate estimates of the mesiodistal widths of unerupted permanent canines and premolars than the Tanaka and Johnston method and may serve as reliable tools for mixed dentition space analysis in Egyptian adolescents. CI - (c) 2026. The Author(s). FAU - El-Desouky, Shaimaa S AU - El-Desouky SS AD - Pediatric Dentistry, Oral Health, and Preventive Dentistry Department, Faculty of Dentistry, Tanta University, Tanta, Egypt. FAU - Hadwa, Shimaa M AU - Hadwa SM AD - Pediatric Dentistry, Oral Health, and Preventive Dentistry Department, Faculty of Dentistry, Tanta University, Tanta, Egypt. FAU - Kabbash, Ibrahim A AU - Kabbash IA AD - Public Health & Community Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt. FAU - Alawy, Safa B AU - Alawy SB AUID- ORCID: 0000-0002-2761-1923 AD - Orthodontics Department, Faculty of Dentistry, Tanta University, Tanta, Egypt. safa_basyouny@dent.tanta.edu.eg. LA - eng PT - Journal Article DEP - 20260911 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - *Bicuspid/anatomy & histology MH - *Cuspid/anatomy & histology MH - Adolescent MH - Humans MH - Female MH - Egypt MH - Male MH - Retrospective Studies MH - *Tooth, Unerupted/anatomy & histology MH - Cross-Sectional Studies MH - Dentition, Mixed MH - *Odontometry/methods MH - Regression Analysis MH - Dental Arch/anatomy & histology MH - Models, Dental MH - Maxilla/anatomy & histology MH - Mandible PMC - PMC13570539 OTO - NOTNLM OT - Canine OT - Mixed dentition OT - Prediction OT - Premolar OT - Regression equation COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was secured from the Research Ethics Committee (REC) of the Faculty of Dentistry at Tanta University, under code (#R-PED-5-24-3107), in accordance with the Helsinki Declaration of 1964 and its subsequent amendments. The study was retrospective and non-interventional; consequently, patients did not receive any treatment related to the study. As all participants were adolescents aged 13-17 years, written informed consent to participate was obtained from the parents or legal guardians of all participants at the time of their initial attendance at the outpatient clinics, together with assent from the adolescent participants. Consent included permission to use anonymized dental casts and clinical records for future retrospective research purposes. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/09/11 CRDT- 2026/09/12 05:21 PHST- 2026/02/15 00:00 [received] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 05:21 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.1186/s12903-026-09706-4 [pii] AID - 9706 [pii] AID - 10.1186/s12903-026-09706-4 [doi] PST - epublish SO - BMC Oral Health. 2026 Sep 11;26(1):1710. doi: 10.1186/s12903-026-09706-4. PMID- 42728168 OWN - NLM STAT- Publisher LR - 20260911 IS - 1878-1861 (Electronic) IS - 1878-1861 (Linking) DP - 2026 Aug 21 TI - The evaluation of a family-based multiple health behaviour intervention targeting girls: The Beyond the 80 feasibility trial. LID - S1440-2440(26)00530-X [pii] LID - 10.1016/j.jsams.2026.08.209 [doi] AB - OBJECTIVES: To examine the feasibility and acceptability of Beyond the 80 (BT80), a family-based healthy lifestyle intervention for school-aged girls. DESIGN: Single-arm mixed-methods feasibility trial. METHODS: BT80 was an 8-week intervention co-delivered with a National Rugby League Women's Premiership team. Eligible families included >/=1 parent and a daughter aged 7-11 years. Families participated in weekly in-person educational and practical sessions and completed home-based challenges. Topics included physical activity (including muscle-strengthening activity), sedentary behaviour, healthy eating, communication, emotion literacy, and sleep. A priori targets were set for recruitment (20 families), attendance (70%), retention (70%), fidelity (checklist; 80%), and enjoyment (self-report; 80%). Child engagement (active/passive engagement or interfering behaviour via direct observation), compliance (photo evidence of home-based challenges completed), and acceptability (child/parent self-report and focus groups) were also assessed. RESULTS: Recruitment (N = 12 families) and attendance (68%) targets were not met, whilst retention (92%) met the target. Intervention fidelity was high (98% education, 100% practical), as was child active/passive engagement (90% education, 96% practical). Child and parent enjoyment was high for educational (child: 82%, parent: 99%) and practical sessions (child: 87%, parent: 98%). Families completed on average 1-2 home-based challenges, and some families found photo submission burdensome. Data collection averaged 102.1 +/- 25.6 min at baseline and 69.7 +/- 17.9 min at intervention end. Parents found the time and measures acceptable. CONCLUSIONS: The preliminary findings for BT80 are promising, however, recruitment strategies, attendance, and home-based challenge engagement require refinement. Our findings may help to inform the development and refinement of similar family-based interventions. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - El Masri, Aymen AU - El Masri A AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. FAU - George, Emma S AU - George ES AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. FAU - West, Nicholas K AU - West NK AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia. FAU - Kennedy, Sarah G AU - Kennedy SG AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. FAU - Hliounakis, Holly AU - Hliounakis H AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia. FAU - Fleming, Catharine A K AU - Fleming CAK AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. FAU - Mackenzie, Erin AU - Mackenzie E AD - Translational Health Research Institute, Western Sydney University, Australia; Faculty of Social Sciences, Arts, Business, Education and Law, Western Sydney University, Australia. FAU - Guagliano, Justin M AU - Guagliano JM AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. Electronic address: j.guagliano@westernsydney.edu.au. LA - eng PT - Journal Article DEP - 20260821 PL - Australia TA - J Sci Med Sport JT - Journal of science and medicine in sport JID - 9812598 SB - IM OTO - NOTNLM OT - Family functioning OT - Healthy eating OT - Muscle strengthening OT - Physical activity OT - Sedentary behaviour OT - Sleep COIS- Declaration of interest statement None. EDAT- 2026/09/11 23:36 MHDA- 2026/09/11 23:36 CRDT- 2026/09/11 21:58 PHST- 2026/02/01 00:00 [received] PHST- 2026/07/20 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/11 23:36 [medline] PHST- 2026/09/11 23:36 [pubmed] PHST- 2026/09/11 21:58 [entrez] AID - S1440-2440(26)00530-X [pii] AID - 10.1016/j.jsams.2026.08.209 [doi] PST - aheadofprint SO - J Sci Med Sport. 2026 Aug 21:S1440-2440(26)00530-X. doi: 10.1016/j.jsams.2026.08.209. PMID- 42727707 OWN - NLM STAT- Publisher LR - 20260911 IS - 2589-5559 (Electronic) IS - 2589-5559 (Linking) DP - 2026 Sep 11 TI - Prevalence and Significance of Combined Low Muscle Volume and High Muscle Fat in Patients with Child-Pugh A-B Cirrhosis. PG - 102031 LID - S2589-5559(26)00302-2 [pii] LID - 10.1016/j.jhepr.2026.102031 [doi] AB - BACKGROUND & AIMS: Physical frailty and sarcopenia are linked to adverse outcomes and higher healthcare utilisation in liver cirrhosis. A magnetic resonance imaging (MRI) assessment combining thigh muscle volume and muscle fat infiltration identifies muscle composition (MC) phenotypes, where adverse MC (high fat, low volume) independently predicts all-cause mortality. We aimed to determine MC prevalence, correlate MRI measurements with functional and physical performance tests, and characterise MC groups in patients with liver cirrhosis undergoing hepatocellular carcinoma (HCC) surveillance. METHODS: The ACCESS-ESLD study prospectively enrolled 150 patients with liver cirrhosis. An abbreviated MRI (for HCC surveillance and an assessment of muscle quantity and body fat), blood sampling (Child-Pugh, MELD 3.0), a Short Physical Performance Battery (SPPB) test, and a Liver Frailty Index (LFI) test were performed. RESULTS: Out of 150 patients (57% males, mean age 64+/-11 years, BMI 29.3+/-5.6 kg/m(2)), 44% had alcohol-related liver disease and 28% had MASLD. Ninety per cent were Child-Pugh A, and the mean MELD was 8.9. Adverse MC was found in 21% of patients, who showed higher LFI, poorer SPPB, and 1.6 L more visceral fat. No differences in Child-Pugh, MELD, decompensation history, type 2 diabetes, or BMI were observed. Muscle measurements strongly correlated with frailty and physical tests, with muscle fat most strongly linked to the LFI and the SPPB. CONCLUSIONS: Incorporating a concise MRI protocol to assess muscle health into HCC surveillance effectively identifies one in five patients with higher frailty and poorer physical performance, independent of liver disease status. Assessing both muscle fat and volume provides additional benefit beyond muscle volume alone. IMPACT AND IMPLICATIONS: This study provides scientific justification for utilising a concise magnetic resonance imaging (MRI) protocol to assess muscle health during MR-based HCC surveillance in patients with liver cirrhosis, demonstrating its feasibility as a combined MRI-based tool for integrated diagnostics. By effectively identifying patients with adverse muscle composition, linked to higher frailty and poorer physical performance, our findings highlight a patient cohort that warrants future targeted research and the development of specific clinical strategies. The findings suggest that assessing both muscle fat and volume provides a more comprehensive understanding of muscle health than assessing muscle volume alone, potentially leading to more effective management strategies. Future longitudinal data from ACCESS-ESLD will be vital to further explore long-term outcomes and inform the clinical utility of such integrated assessments, ultimately informing refined clinical practices and patient care. CLINICAL TRIAL NUMBER: NCT05502198. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Forsgren, Mikael Fredrik AU - Forsgren MF AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; AMRA Medical AB, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden. Electronic address: mikael.f.forsgren@liu.se. FAU - Sjogren, Daniel AU - Sjogren D AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Department of Medicine, Hoglandssjukhuset Eksjo, Region Jonkoping County Council, Eksjo, Sweden. FAU - Stjernman, Henrik AU - Stjernman H AD - Department of Internal Medicine, Ryhov Hospital Jonkoping, Region Jonkoping County Council, Jonkoping, Sweden. FAU - Nasr, Patrik AU - Nasr P AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Gastroenterology and Hepatology in Linkoping, Region Ostergotland, Linkoping, Sweden; Wallenberg Center for Molecular Medicine (WCMM), Linkoping University, Linkoping, Sweden. FAU - Balkhed, Wile AU - Balkhed W AD - Clinical Department of Gastroenterology and Hepatology in Linkoping, Region Ostergotland, Linkoping, Sweden. FAU - Cederborg, Anna AU - Cederborg A AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden; Department of Medicine, Sahlgrenska University Hospital, Goteborg, Sweden. FAU - Holmberg, Markus AU - Holmberg M AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden. FAU - Bartholoma, Wolf AU - Bartholoma W AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Radiology in Linkoping, Region Ostergotland, Linkoping, Sweden. FAU - Jonsson, Cecilia AU - Jonsson C AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden. FAU - Lundberg, Peter AU - Lundberg P AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Radiology in Linkoping, Region Ostergotland, Linkoping, Sweden; Clinical Department of Medical Radiation Physics, Region Ostergotland, Linkoping, Sweden. FAU - Rejler, Martin AU - Rejler M AD - Futurum, Academy for Healthcare, Region Jonkoping County, Jonkoping, Sweden; The Jonkoping Academy for Improvement of Health and Welfare, Halsohogskolan, Jonkoping University, Jonkoping, Sweden. FAU - Dahlstrom, Nils AU - Dahlstrom N AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Radiology in Linkoping, Region Ostergotland, Linkoping, Sweden. FAU - Kechagias, Stergios AU - Kechagias S AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Clinical Department of Gastroenterology and Hepatology in Linkoping, Region Ostergotland, Linkoping, Sweden. FAU - Leinhard, Olof Dahlqvist AU - Leinhard OD AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; AMRA Medical AB, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden. FAU - Ekstedt, Mattias AU - Ekstedt M AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Gastroenterology and Hepatology in Linkoping, Region Ostergotland, Linkoping, Sweden. LA - eng SI - ClinicalTrials.gov/NCT05502198 PT - Journal Article DEP - 20260911 PL - Netherlands TA - JHEP Rep JT - JHEP reports : innovation in hepatology JID - 101761237 SB - IM OTO - NOTNLM OT - Adverse muscle composition OT - Body composition OT - Frailty OT - HCC surveillance OT - Liver cirrhosis OT - Magnetic resonance imaging OT - Muscle composition OT - Muscle fat OT - Muscle volume COIS- Declaration of Competing Interest: MF is a shareholder and employee of AMRA Medical AB. PN has served on an advisory board for Boehringer Ingelheim. AC has received lecture fees from Norgine Denmark A/S. PL is shareholder of AMRA Medical AB. ODL is an employee, shareholder, and board member of AMRA Medical AB. ME has received lecture fees from Mediplast and Novo Nordisk and has served on an advisory board for Ipsen. No other author has any competing interest. EDAT- 2026/09/11 23:36 MHDA- 2026/09/11 23:36 CRDT- 2026/09/11 19:20 PHST- 2026/02/17 00:00 [received] PHST- 2026/09/02 00:00 [revised] PHST- 2026/09/05 00:00 [accepted] PHST- 2026/09/11 23:36 [medline] PHST- 2026/09/11 23:36 [pubmed] PHST- 2026/09/11 19:20 [entrez] AID - S2589-5559(26)00302-2 [pii] AID - 10.1016/j.jhepr.2026.102031 [doi] PST - aheadofprint SO - JHEP Rep. 2026 Sep 11:102031. doi: 10.1016/j.jhepr.2026.102031. PMID- 42727054 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260929 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 Sep 11 TI - Smartphone Apps for Preventing Adolescent Health Problems Among Health Care Professionals: Systematic Search and Quality Assessment. PG - e83908 LID - 10.2196/83908 [doi] LID - e83908 AB - BACKGROUND: Health care professionals must consider multiple dimensions of prevention when consulting with adolescents. Identifying risky behaviors early in adolescence is crucial for reducing both morbidity and mortality. General practitioners are increasingly eager to incorporate digital tools for prevention into their consultations with adolescents; however, the relevance and clinical validity of these digital tools are not always established or well-known. Consequently, primary care professionals require guidance and support in selecting relevant mobile health (mHealth) tools. OBJECTIVE: The aim of this study is to identify relevant and useful digital apps to help primary care professionals detect at-risk adolescents across all recommended areas of prevention: orthopedics, mental health, substance abuse, risk behaviors, sexual health, vaccinations, social relationships, and nutrition. METHODS: A systematic review of smartphone apps, with an analysis of content quality, was carried out by 4 researchers using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist. The App Store and Google Play Store platforms were surveyed. The inclusion criteria were as follows: free of charge, date of last update, availability in French or English, relevance of the preventive approach to adolescents, and scientific validation. Four health care professionals assessed the apps: 2 selected the apps relevant to health care professionals, then 3 analyzed these apps using the French version of the Mobile App Rating Scale (MARS-F). Intraclass correlation coefficient, model (2,1) (2-way random effects, absolute agreement, single measures); standard error of measurement; and mean absolute error were also calculated. RESULTS: A total of 976 apps were identified, 49 of which had disappeared from the platforms prior to analysis. Nine apps were retained. Seven (0.72%) were included after evaluation using the MARS-F: 2 on mental health and 5 on sexual health (including 3 on contraception only). The mean MARS-F interrater score ranged from 2.5/5 to 3.8/5. The global MARS-F score demonstrated a pooled SD of 0.60 and an intraclass correlation coefficient (2,1) of 0.0003, resulting in a calculated standard error of measurement of 0.60. The average discrepancy between raters was a mean absolute error of 0.53. CONCLUSIONS: No similar studies have been identified in the literature that specifically focus on mobile apps designed to support health care professionals in delivering preventive care to adolescents. Of the 8 areas of prevention identified as relevant for adolescents, only 3 are addressed by the apps validated through our methodology (5 focus on sexual health). Consequently, current apps are insufficient to support health care professionals in their overall preventive work with adolescents. Such a review should be conducted systematically prior to the development of any new tool to prevent duplication and channel creative efforts toward truly innovative digital solutions. Furthermore, a thorough analysis of relevant, recommended websites is essential, as these resources complement the use of mobile apps designed for health care professionals. CI - (c) Elodie Million, Marijn Kuijper, Carole Bautista, Lola Pirat, Bruno Falissard, Beatrice Lognos, Francois Carbonnel. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Million, Elodie AU - Million E AUID- ORCID: 0000-0001-5693-6594 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. AD - Desbrest Institute of Epidemiology and Public Health (IDESP), UMR UA11 INSERM, University of Montpellier, Montpellier, France. FAU - Kuijper, Marijn AU - Kuijper M AUID- ORCID: 0009-0000-6223-3510 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. FAU - Bautista, Carole AU - Bautista C AUID- ORCID: 0009-0006-4712-7529 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. FAU - Pirat, Lola AU - Pirat L AUID- ORCID: 0009-0006-2249-0874 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. FAU - Falissard, Bruno AU - Falissard B AUID- ORCID: 0000-0002-2418-4954 AD - CESP (Centre for Research in Epidemiology and Population Health, INSERM), University Paris Sarclay, Paris, France. FAU - Lognos, Beatrice AU - Lognos B AUID- ORCID: 0000-0002-1032-3167 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. AD - Desbrest Institute of Epidemiology and Public Health (IDESP), UMR UA11 INSERM, University of Montpellier, Montpellier, France. FAU - Carbonnel, Francois AU - Carbonnel F AUID- ORCID: 0000-0002-8470-4798 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. AD - Desbrest Institute of Epidemiology and Public Health (IDESP), UMR UA11 INSERM, University of Montpellier, Montpellier, France. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260911 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Adolescent MH - Humans MH - *Adolescent Health/standards/trends MH - Digital Health MH - *Health Personnel/psychology/statistics & numerical data MH - *Mobile Applications/standards/statistics & numerical data/trends MH - Quality Assurance, Health Care/methods MH - Smartphone/instrumentation PMC - PMC13568167 OTO - NOTNLM OT - adolescent OT - mental health OT - mobile apps OT - preventive medicine OT - primary care OT - sexual health COIS- Conflicts of Interest: None declared. EDAT- 2026/09/11 17:36 MHDA- 2026/09/11 17:37 PMCR- 2026/09/11 CRDT- 2026/09/11 16:13 PHST- 2025/09/10 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/09/11 17:37 [medline] PHST- 2026/09/11 17:36 [pubmed] PHST- 2026/09/11 16:13 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - v14i1e83908 [pii] AID - 83908 [pii] AID - 10.2196/83908 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Sep 11;14:e83908. doi: 10.2196/83908. PMID- 42726424 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260914 IS - 2196-1042 (Electronic) IS - 1723-7785 (Print) IS - 1723-7785 (Linking) VI - 27 IP - 1 DP - 2026 Sep 11 TI - Digital analysis of age-related dentoalveolar changes: a 50-year longitudinal study. LID - 10.1186/s40510-026-00643-0 [doi] LID - 41 AB - BACKGROUND: With the growing demand for orthodontic treatment among adults, a clear understanding of the age-related dentoalveolar changes has become increasingly important for accurate diagnosis, treatment planning, and long-term retention strategies. This study aims to characterize dentoalveolar changes in individuals with normal occlusion from early adolescence (13 years) to late adulthood (62 years) across four time points, using digitally derived measurements and strict inclusion and exclusion criteria. METHODOLOGY: Thirty orthodontically untreated subjects (11 males, 19 females) recruited through the Public Dental Health Care system in, were examined at mean ages of 13 (T1), 16 (T2), 31 (T3), and 62 years (T4). Stone casts of the maxillary and mandibular arches were digitized using a high-resolution 3D scanner. Eleven variables were digitally assessed: overjet, overbite, intercanine width, intermolar width, arch depth, palatal height, curve of Spee, clinical crown height, arch length, space deficiency, and irregularity index. Changes across time points were analyzed using the Wilcoxon signed-rank test. RESULTS: Sagittally, overjet remained stable, whereas arch depth decreased significantly in both arches. Vertically, overbite decreased significantly, while clinical crown height increased significantly in both arches. Palatal height increased significantly up to age 31, and the curve of Spee decreased significantly by age 16. Transversely, maxillary and mandibular intermolar widths, as well as maxillary intercanine width, showed no significant changes, whereas mandibular intercanine width decreased significantly. In terms of space, maxillary and mandibular arch lengths decreased significantly at all time points, accompanied by significant increases in space deficiency and in the irregularity of the mandibular incisors throughout the observation period. CONCLUSIONS: Age-related dentoalveolar changes continue from adolescence into late adulthood, supporting the concept that occlusion remains dynamic throughout life. These longitudinal findings provide clinically relevant reference data for orthodontic diagnosis, treatment planning, and the development of effective long-term retention strategies. CI - (c) 2026. The Author(s). FAU - Basim, Anas AU - Basim A AD - Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Naoumova, Julia AU - Naoumova J AD - Department of Orthodontics, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Public Dental Service, University Clinic of Orthodontics, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Leffler, Klara AU - Leffler K AD - Department of Mathematical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Johansson, Kristina AU - Johansson K AD - Orthodontics, Department of Odontology, Faculty of Medicine, Umea University, Umea, Sweden. FAU - Persson, Maurits AU - Persson M AD - Orthodontics, Department of Odontology, Faculty of Medicine, Umea University, Umea, Sweden. FAU - Al-Taai, Nameer AU - Al-Taai N AD - Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. nameer.altaai@dubaihealth.ae. AD - Orthodontics, Department of Odontology, Faculty of Medicine, Umea University, Umea, Sweden. nameer.altaai@dubaihealth.ae. LA - eng PT - Journal Article DEP - 20260911 PL - Germany TA - Prog Orthod JT - Progress in orthodontics JID - 100936353 SB - IM MH - Humans MH - Female MH - Longitudinal Studies MH - *Dental Arch/anatomy & histology/growth & development MH - Adolescent MH - Maxilla/anatomy & histology/growth & development MH - Mandible/anatomy & histology/growth & development MH - Middle Aged MH - Overbite/pathology MH - Male MH - Imaging, Three-Dimensional/methods MH - Age Factors MH - Incisor/anatomy & histology MH - Models, Dental MH - Young Adult MH - Cephalometry/methods MH - Tooth Crown/anatomy & histology MH - *Aging MH - Cuspid/anatomy & histology MH - *Alveolar Process/anatomy & histology/growth & development MH - Image Processing, Computer-Assisted/methods MH - Adult PMC - PMC13569759 OTO - NOTNLM OT - Age-related changes OT - Incisor crowding OT - Intercanine width OT - Intraclass correlation coefficient COIS- Declarations. Ethics approval: Ethical approval for this study was obtained from the Regional Ethical Board at Umea University, Sweden (registration no. 2012-410 - 31 M). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Co-author Julia Naoumova is an Associate Editor for Progress in Orthodontics and was not involved in the editorial evaluation or peer-review process of this manuscript. EDAT- 2026/09/11 17:36 MHDA- 2026/09/11 17:37 PMCR- 2026/09/11 CRDT- 2026/09/11 13:10 PHST- 2026/03/27 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/11 17:37 [medline] PHST- 2026/09/11 17:36 [pubmed] PHST- 2026/09/11 13:10 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.1186/s40510-026-00643-0 [pii] AID - 643 [pii] AID - 10.1186/s40510-026-00643-0 [doi] PST - epublish SO - Prog Orthod. 2026 Sep 11;27(1):41. doi: 10.1186/s40510-026-00643-0. PMID- 42726140 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 10 DP - 2026 Sep 11 TI - Clinical and immunological predictors of baked egg tolerance in children with IgE-mediated hen's egg allergy: a cross-sectional diagnostic accuracy study. LID - 742 [pii] LID - 10.1007/s00431-026-07398-0 [doi] AB - Baked egg (BE) introduction in IgE-mediated hen's egg allergy (HEA) is a practical strategy for dietary diversification and may promote future tolerance to hen's egg. This study aims to characterise clinical and immunological profile of children with HEA undergoing BE oral food challenge (BE-OFC) and to evaluate the individual and combined predictive performance of serum-specific IgE (sIgE), skin prick test (SPT), and basophil activation test (BAT) for BE tolerance. This is a cross-sectional diagnostic accuracy study of children aged 12 months to less than 6 years with confirmed IgE-mediated HEA attending a tertiary referral centre in Barcelona. All participants underwent standardised open BE-OFC. Receiver operating characteristic (ROC) analysis was used to evaluate biomarker performance. Exploratory associations with BE tolerance were examined using Firth's penalised logistic regression. Fifty-one children completed BE-OFC; 56.9% were tolerant. Tolerance was lower in those with prior anaphylaxis (35.7% vs 64.9%), without statistical significance (p = 0.111). During BE-OFC, epinephrine was required in only two of 22 non-tolerant patients. Ovomucoid (OVM)-sIgE was the best-performing single biomarker (AUC 0.71; 95% CI 0.55-0.87; cutoff 4.48 kUA/L; sensitivity 68.2%; specificity 79.3%). Tolerant patients demonstrated lower BAT net stimulation responses across egg white concentrations. Neither SPT nor BAT markers achieved meaningful discrimination. In adjusted analyses, OVM-sIgE retained a significant independent association with BE tolerance (OR 6.2; 95% CI 1.9-22.8), while the effect of age was attenuated to non-significance. Conclusion: OVM-sIgE was the strongest predictor of BE tolerance in young children with IgE-mediated HEA. Supervised OFC appears safe even in children with prior anaphylaxis. Findings are exploratory and require prospective multicentre validation. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Machinena-Spera, Adrianna AU - Machinena-Spera A AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. adrianna.machinena@sjd.es. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. adrianna.machinena@sjd.es. AD - Department of Surgery and Surgical Specializations, Facultat de Medicina I Ciencies de La Salut, Universitat de Barcelona, Barcelona, Spain. adrianna.machinena@sjd.es. FAU - Lozano-Blasco, Jaime AU - Lozano-Blasco J AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Jimenez-Feijoo, Rosa AU - Jimenez-Feijoo R AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Dominguez, Olga AU - Dominguez O AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Poyatos, Elisabet AU - Poyatos E AD - Clinical Laboratory, Immunology Division, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Riggioni, Carmen AU - Riggioni C AD - Division of Immunology and Allergy, The Hospital for Sick Children and the SickKids Food Allergy and Anaphylaxis Program, Toronto, ON, Canada. AD - Department of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Del Mar Folque-Gimenez, Maria AU - Del Mar Folque-Gimenez M AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Piquer-Gibert, Monica AU - Piquer-Gibert M AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Salamanca-Fernandez, Guillermo AU - Salamanca-Fernandez G AD - Medical Affairs Unit, LETI Pharma, Tres Cantos, Madrid, Spain. FAU - Sandoval-Ruballos, Monica AU - Sandoval-Ruballos M AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Bolos, Uma AU - Bolos U AD - Immunology Department, CDB, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Torradeflot, Maria AU - Torradeflot M AD - Immunology Department, CDB, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - de Landazuri, Inaki Ortiz AU - de Landazuri IO AD - Immunology Department, CDB, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Institut d'Investigacio Biomedica August Pi I Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. FAU - Alsina, Laia AU - Alsina L AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. AD - Department of Surgery and Surgical Specializations, Facultat de Medicina I Ciencies de La Salut, Universitat de Barcelona, Barcelona, Spain. AD - Study Group for Immune Dysfunction Diseases in Children (GEMDIP), Institute of Recerca Sant Joan de Deu, Barcelona, Spain. FAU - Pascal, Mariona AU - Pascal M AD - Immunology Department, CDB, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Institut d'Investigacio Biomedica August Pi I Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. AD - Department of Medicine, Universitat de Barcelona, Barcelona, Spain. AD - RETICS Asma, Reacciones Adversas y Alergicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI), Instituto Carlos III, Madrid, Spain. FAU - Alvaro-Lozano, Montserrat AU - Alvaro-Lozano M AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. AD - Department of Surgery and Surgical Specializations, Facultat de Medicina I Ciencies de La Salut, Universitat de Barcelona, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260911 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 37341-29-0 (Immunoglobulin E) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Egg Hypersensitivity/immunology/diagnosis MH - Female MH - Cross-Sectional Studies MH - *Immunoglobulin E/blood/immunology MH - Child, Preschool MH - Male MH - Skin Tests MH - Infant MH - *Immune Tolerance/immunology MH - ROC Curve MH - Biomarkers/blood MH - Predictive Value of Tests MH - Basophil Degranulation Test MH - Cooking MH - Anaphylaxis/immunology OTO - NOTNLM OT - Baked egg OT - Basophil activation test OT - Hen's egg allergy OT - Oral food challenge OT - Ovomucoid-specific IgE COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Review Board of Hospital Sant Joan de Deu, Barcelona (reference number PIC-104-14). Consent to participate: Written informed consent was obtained from the parents or legal guardians of all participants prior to enrolment. Consent for publication: No individual person's data in any identifiable form is included in this manuscript. Aggregate and anonymised data are reported throughout. Consent to publish was obtained as part of the informed consent process. Competing interests: The authors declare no competing interests. EDAT- 2026/09/11 17:36 MHDA- 2026/09/11 17:37 CRDT- 2026/09/11 12:51 PHST- 2026/06/04 00:00 [received] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/08/19 00:00 [revised] PHST- 2026/09/11 17:37 [medline] PHST- 2026/09/11 17:36 [pubmed] PHST- 2026/09/11 12:51 [entrez] AID - 10.1007/s00431-026-07398-0 [pii] AID - 10.1007/s00431-026-07398-0 [doi] PST - epublish SO - Eur J Pediatr. 2026 Sep 11;185(10):742. doi: 10.1007/s00431-026-07398-0. PMID- 42724880 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2392-1099 (Print) IS - 2449-8238 (Electronic) IS - 2392-1099 (Linking) VI - 12 IP - 2 DP - 2026 Jun TI - Are there any non-invasive methods to predict liver fibrosis in children infected by hepatitis C virus rather than liver biopsy? PG - 136-148 LID - 10.5114/ceh.2026.161502 [doi] AB - AIM OF THE STUDY: Since biopsy is an invasive procedure that is not suitable for routine monitoring, and hepatitis C virus (HCV) infection in children can lead to progressive liver damage, liver fibrosis, and its sequela, cirrhosis, aspartate aminotransferase (AST)-to-platelet ratio (APRI) and the fibrosis score (FIB-4) are increasingly substituting biopsy in the evaluation of liver fibrosis. APRI and FIB-4 are promising non-invasive markers for the safe and effective assessment of liver fibrosis. Thus, this study aimed to ascertain whether APRI and FIB-4 scores may be used to identify the stage of liver fibrosis among children diagnosed with HCV. MATERIAL AND METHODS: From July 2024 to August 2025, a total of 120 children diagnosed with HCV were enrolled in a retrospective study conducted at the Department of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University. The study population was divided into two groups: 22 patients were classified as the > F2 group, while 98 patients were assigned to the F2 group. More importantly, the > F2 group had considerably higher APRI, levels of serum albumin and FIB-4 than the 3 h/week) less time on the computer (51.0% vs. 33.0% reported <1 h/d) compared to non-sports club members (P<0.001) but there was no significant difference in mobile phone use and TV time. CONCLUSIONS: The present results show that low fiber intake is widespread among adolescents and that longer screen time and low PA are associated with a low fiber intake, which indicates a clustering of health behaviors. Accordingly, intervention strategies may target several behaviors to promote health in youth. CI - (c) AME Publishing Company. FAU - Greier, Carla AU - Greier C AD - Department of Sports Science, University of Innsbruck, Innsbruck, Austria. FAU - Drenowatz, Clemens AU - Drenowatz C AUID- ORCID: 0000-0002-3861-5364 AD - Division of Sport, Physical Activity and Health, University of Education Upper Austria, Linz, Austria. FAU - Dudas, Jozsef AU - Dudas J AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria. FAU - Ruedl, Gerhard AU - Ruedl G AD - Department of Sports Science, University of Innsbruck, Innsbruck, Austria. FAU - Posch, Markus AU - Posch M AD - Division of Physical Education, Private University of Education (KPH-ES), Stams, Austria. FAU - Greier, Klaus AU - Greier K AD - Department of Sports Science, University of Innsbruck, Innsbruck, Austria. LA - eng PT - Journal Article DEP - 20260827 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559115 OTO - NOTNLM OT - Diet OT - computer time OT - media use OT - sports OT - television time (TV time) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0432/coif). C.D. serves as an unpaid editorial board member of Translational Pediatrics from May 2026 to December 2027. The other authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:35 PHST- 2026/05/04 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:35 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-299 [pii] AID - 10.21037/tp-2026-0432 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):299. doi: 10.21037/tp-2026-0432. Epub 2026 Aug 27. PMID- 42724397 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - Clinical factors associated with extrapulmonary complications in children with macrolide-resistant Mycoplasma pneumoniae pneumonia: a single-center retrospective matched case-control study. PG - 309 LID - 10.21037/tp-2026-0451 [doi] LID - 309 AB - BACKGROUND: Extrapulmonary complications contribute substantially to the clinical burden of macrolide-resistant Mycoplasma pneumoniae pneumonia (R-MPP), but factors associated with these events and their combined discriminatory value remain insufficiently characterized. This study examined clinical, laboratory, radiographic, and treatment-related factors associated with extrapulmonary complications and developed a simplified classification model. METHODS: This single-center retrospective matched case-control study included children aged 3-14 years hospitalized between January 2021 and June 2024. Among 684 potentially eligible children identified from electronic medical record and microbiology databases, 448 met the criteria for genotypically confirmed R-MPP. All 52 children who developed extrapulmonary complications during the index hospitalization were included as cases. From 396 children without complications, 156 controls were individually matched at a 1:3 ratio by sex, age within 6 months, and admission date within 30 days. Candidate variables included peak inflammatory biomarkers, nadir platelet count, respiratory and computed tomography (CT) severity, and intervals from symptom onset to medical consultation and macrolide initiation. Complete-case conditional logistic regression stratified by matched set was the primary analysis; least absolute shrinkage and selection operator (LASSO) was used for variable selection, and multiple imputation was performed as a sensitivity analysis. RESULTS: Cases and controls were comparable in age, sex, admission period, nutritional status, residence, vaccination status, household tobacco exposure, and wheezing history. C-reactive protein (CRP) >100 mg/L [matched odds ratio (OR) =3.28; 95% confidence interval (CI): 1.70-6.34], lactate dehydrogenase (LDH) >400 U/L (OR =2.97; 95% CI: 1.56-5.65), macrolide initiation delay >7 days (OR =4.18; 95% CI: 2.16-8.08), and severe CT changes (OR =2.15; 95% CI: 1.08-4.29) were independently associated with complications. A three-variable model incorporating CRP, LDH, and macrolide delay achieved an optimism-corrected area under the receiver operating characteristic (ROC) curve (AUC) of 0.917, with 86.5% sensitivity and 88.5% specificity. A preliminary internal temporal assessment in 44 patients yielded an AUC of 0.892. CONCLUSIONS: Elevated CRP, elevated LDH, delayed macrolide initiation, and severe CT changes were associated with extrapulmonary complications in hospitalized children with R-MPP. The simplified model may support clinical classification, but the retrospective design, concurrent biomarker measurement, and limited temporal sample preclude causal interpretation or immediate implementation. Larger multicenter studies are required for formal validation. CI - (c) AME Publishing Company. FAU - Xu, Tianfu AU - Xu T AD - Department of Pediatrics, The Affiliated Hospital (Group) of Putian University, Putian, China. FAU - Yan, Seyan AU - Yan S AD - Department of Pediatrics, The Affiliated Hospital (Group) of Putian University, Putian, China. FAU - Huang, Saiping AU - Huang S AD - Department of Pediatrics, The Affiliated Hospital (Group) of Putian University, Putian, China. LA - eng PT - Journal Article DEP - 20260730 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559145 OTO - NOTNLM OT - Macrolide-resistant Mycoplasma pneumoniae pneumonia (R-MPP) OT - classification model OT - extrapulmonary complications OT - pediatric pneumonia OT - treatment delay COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0451/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:32 PHST- 2026/05/09 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:32 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-309 [pii] AID - 10.21037/tp-2026-0451 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):309. doi: 10.21037/tp-2026-0451. Epub 2026 Jul 30. PMID- 42724392 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - The global landscape of pediatric hyperuricemia research: a bibliometric roadmap to mechanisms, management, and future therapeutics (1997-2024). PG - 339 LID - 10.21037/tp-2026-0255 [doi] LID - 339 AB - BACKGROUND: Pediatric hyperuricemia has emerged as a significant global health concern, intricately linked to the early pathogenesis of metabolic syndrome, cardiovascular disease, and chronic kidney disease. Despite extensive research in adults, critical gaps persist in our understanding of its unique pathophysiology, age-specific diagnostic criteria, and evidence-based management strategies in children. This study aims to provide a comprehensive, quantitative assessment of the global research landscape on pediatric hyperuricemia, identify pivotal thematic foci, and map emerging frontiers to guide future scientific inquiry and clinical translation. METHODS: We conducted a systematic bibliometric and visual analysis of all relevant articles and reviews indexed in the Web of Science Core Collection (WoS CC) from inception to December 20, 2024. Data were synthesized using VOSviewer, CiteSpace, and the Bibliometrix R package to construct collaboration networks, perform co-citation analyses, and track keyword evolution. RESULTS: Our analysis identified 189 publications, revealing a trajectory of fluctuating but overall increasing scholarly attention. China (n=47) and the United States (n=43) were the most prolific contributors, with St. Jude Children's Research Hospital and Harvard University leading institutional output. Authors Simonetta Genovesi and Marco Giussani were the most productive. Keyword co-occurrence analysis delineated three dominant research clusters: (I) core clinical management ("hyperuricemia", "allopurinol", "rasburicase"); (II) cardiometabolic comorbidities ("obesity", "hypertension", "metabolic syndrome"); and (III) epidemiological and risk factor profiling ("children", "uric acid", "prevalence"). Notably, recent years have witnessed an emergent focus on long-term sequelae, including "chronic kidney disease" and "acute kidney injury". CONCLUSIONS: Research into pediatric hyperuricemia remains nascent yet is rapidly gaining momentum. Our roadmap highlights four critical frontiers: elucidating developmental-stage-specific pathological mechanisms, establishing validated diagnostic thresholds, evaluating the long-term safety and efficacy of both pharmacological and non-pharmacological interventions, and defining strategies for lifelong management to mitigate adult-onset complications. We advocate for enhanced international and interdisciplinary collaboration as the cornerstone for accelerating progress in this vital field. CI - (c) AME Publishing Company. FAU - Xiao, Liang AU - Xiao L AD - Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. FAU - Lu, Wei AU - Lu W AD - Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. FAU - Wang, Junli AU - Wang J AD - Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. FAU - Yu, Shengyou AU - Yu S AD - Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260629 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559144 OTO - NOTNLM OT - Pediatric hyperuricemia OT - bibliometric analysis OT - metabolic syndrome OT - therapeutic innovation OT - uric acid metabolism COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0255/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:32 PHST- 2026/03/13 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:32 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-339 [pii] AID - 10.21037/tp-2026-0255 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):339. doi: 10.21037/tp-2026-0255. Epub 2026 Jun 29. PMID- 42724349 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - Whole-exome sequencing-centered genetic evaluation for early-onset obesity in Chinese children: a retrospective single-center cohort. PG - 330 LID - 10.21037/tp-2026-0407 [doi] LID - 330 AB - BACKGROUND: Genetic causes of early-onset obesity remain undercharacterized in East Asian children. This study evaluated a whole-exome sequencing (WES)-centered diagnostic workflow in Chinese children with obesity onset before 5 years. METHODS: Consecutive children with body mass index above the 95th percentile and obesity onset before 5 years who completed structured inpatient assessment at a single center between February 2022 and December 2023 were retrospectively analyzed. Phenotyping included clinical, biochemical, oral glucose tolerance, cortisol rhythm, and liver assessments. Genetic testing combined WES, mitochondrial DNA analysis, multiplex ligation-dependent probe amplification (MLPA) for obesity-related imprinting loci, WES-based copy-number variant and runs-of-homozygosity analyses, and Sanger validation. Variants were interpreted according to the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) criteria. RESULTS: Among 23 children, clinically relevant genetic findings were identified in 6 (26.1%): melanocortin-4 receptor (MC4R) c.831T>A (p.C277*), maternal uniparental disomy of 15q11-13, and four phenotype-correlated variants of uncertain significance in UCP3, BBS1, NCOA1, and SH2B1. The definitive/likely diagnostic yield, restricted to pathogenic or confirmed imprinting findings, was 8.7% (2/23). Findings involved leptin-MC4R signaling, BBSome function, fatty-acid oxidation, and chromosomal imprinting. Genetically positive children showed numerically higher alanine aminotransferase (ALT) and aspartate aminotransferase (AST), but differences were not statistically significant. BBS1 p.T374S was relatively enriched in East Asian reference data. CONCLUSIONS: A WES-centered integrated workflow detected heterogeneous genetic mechanisms in Chinese children with early-onset obesity, but variant of uncertain significance (VUS)-associated findings should be distinguished from confirmed diagnoses. Orthogonal methylation/MLPA and runs of homozygosity (ROH) analyses were necessary for imprinting diagnosis. Larger multicenter studies and functional validation are needed. CI - (c) AME Publishing Company. FAU - Chen, Si AU - Chen S AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Ge, Liyuan AU - Ge L AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Li, Zhonghui AU - Li Z AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Wang, Liuxu AU - Wang L AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Cheng, Xinran AU - Cheng X AUID- ORCID: 0000-0001-9001-4016 AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. LA - eng PT - Journal Article DEP - 20260722 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559094 OTO - NOTNLM OT - Chinese children OT - Early-onset obesity OT - genetic diagnosis OT - monogenic obesity OT - whole-exome sequencing (WES) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0407/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:28 PHST- 2026/04/23 00:00 [received] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:28 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-330 [pii] AID - 10.21037/tp-2026-0407 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):330. doi: 10.21037/tp-2026-0407. Epub 2026 Jul 22. PMID- 42724246 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - Predictive value of the prognostic nutritional index and aggregate index of systemic inflammation for pulmonary complications in children with influenza. PG - 343 LID - 10.21037/tp-2026-0567 [doi] LID - 343 AB - BACKGROUND: Pulmonary complications drive morbidity in pediatric influenza, but early risk stratification remains challenging. This study evaluated the predictive utility of the prognostic nutritional index (PNI) and the aggregate index of systemic inflammation (AISI)-accessible biomarkers of immune-nutritional and inflammatory status-for pulmonary complications in pediatric influenza. METHODS: This retrospective study analyzed 248 pediatric patients with influenza admitted between January 2022 and December 2024. PNI and AISI were calculated from admission laboratory data. Multivariable logistic regression and receiver operating characteristic (ROC) curves were utilized to evaluate the independent and combined predictive performance of PNI and AISI for the development of pulmonary complications. RESULTS: Pulmonary complications developed in 86 patients (34.7%). These patients exhibited significantly lower PNI and higher AISI than those without complications (both P<0.001). Furthermore, PNI correlated inversely, and AISI positively, with disease severity markers including C-reactive protein (CRP), procalcitonin, fever duration, and hospital length of stay (all P<0.001). Multivariable analysis identified prolonged fever, decreased PNI, and elevated AISI as independent predictors of pulmonary complications. The combined PNI-AISI model showed higher apparent discriminatory performance than PNI or AISI alone [the area under the receiver operating characteristic curve (AUC): 0.913, sensitivity: 87.2%, specificity: 85.2%]; however, further validation is required to confirm its generalizability. CONCLUSIONS: Decreased PNI and elevated AISI independently predict pulmonary complications and disease severity in pediatric influenza. Integrating these indices provides a highly accurate, accessible, and physiologically grounded tool for early risk stratification, optimizing clinical decision-making. CI - (c) AME Publishing Company. FAU - Wu, Yuanyuan AU - Wu Y AD - Department of Pediatrics, The First People's Hospital of Hefei, Hefei, China. FAU - Zhang, Jianjian AU - Zhang J AD - Department of Intensive Care Unit, The First People's Hospital of Hefei, Hefei, China. FAU - Ke, Xuejia AU - Ke X AD - Department of Nursing, The First People's Hospital of Hefei, Hefei City, China. FAU - Pan, Junping AU - Pan J AD - Department of Pediatrics, The First People's Hospital of Hefei, Hefei, China. FAU - Hu, Yuping AU - Hu Y AD - Department of Pediatrics, The First People's Hospital of Hefei, Hefei, China. LA - eng PT - Journal Article DEP - 20260827 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559136 OTO - NOTNLM OT - Influenza OT - aggregate index of systemic inflammation (AISI) OT - children OT - prognostic nutritional index (PNI) OT - pulmonary complications COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0567/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:15 PHST- 2026/06/07 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:15 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-343 [pii] AID - 10.21037/tp-2026-0567 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):343. doi: 10.21037/tp-2026-0567. Epub 2026 Aug 27. PMID- 42724193 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 1356-4765 (Print) IS - 1572-8692 (Electronic) IS - 1356-4765 (Linking) VI - 32 IP - 2 DP - 2026 TI - Let Them Eat Plants! Two Arguments for Raising Children on a (Predominantly) Plant-Based Diet. PG - 175-196 LID - 10.1007/s11158-025-09728-9 [doi] AB - In this article, we present two independent arguments in favor of the view that parents have a pro tanto moral duty to feed their children a predominantly plant-based diet. The first is the 'Animal Harm Argument'. The significant suffering caused to animals by harmful animal agriculture is morally wrong, and consequently there is a moral duty to avoid consuming products coming from such circumstances. In a family context, parents have a moral duty to teach their young children the best 'rules-of-thumb' to comply with morality's demands. Therefore, parents should, as a rule, provide their children with a plant-based diet. The second is the 'Environmental Harm Argument'. Consuming animal products is associated with a large ecological footprint. There is a moral duty to reduce one's ecological footprint, and significant reductions are not feasible without substantially cutting down on animal products, so moving toward a more plant-based diet is morally required. In families, parents have a special responsibility to help reduce their children's ecological footprint, and to prepare them to heed laws requiring such reductions in the future, and therefore should feed them a predominantly plant-based diet. Lastly, we address several objections to our arguments and show why they do not hold. CI - (c) The Author(s) 2025. FAU - Hohl, Sabine AU - Hohl S AUID- ORCID: 0000-0002-0157-559X AD - Universitat Basel, Philosophisches Seminar, Steinengraben 5, 4051 Basel, Switzerland. ROR: https://ror.org/02s6k3f65. GRID: grid.6612.3. ISNI: 0000 0004 1937 0642 FAU - Martin, Angela K AU - Martin AK AD - University of Fribourg, Environmental Sciences and Humanities Institute, Ch. du Musee 4, 1700 Fribourg, Switzerland. ROR: https://ror.org/022fs9h90. GRID: grid.8534.a. ISNI: 0000 0004 0478 1713 LA - eng PT - Journal Article DEP - 20250821 PL - England TA - Res Publica JT - Res publica (Liverpool, England) JID - 100973395 PMC - PMC13558363 OTO - NOTNLM OT - Animal ethics OT - Children OT - Environmental ethics OT - Family ethics OT - Moral education OT - Plant-based diet OT - Veganism COIS- Conflict of interestNo conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2025/08/21 CRDT- 2026/09/11 09:10 PHST- 2025/06/18 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:10 [entrez] PHST- 2025/08/21 00:00 [pmc-release] AID - 9728 [pii] AID - 10.1007/s11158-025-09728-9 [doi] PST - ppublish SO - Res Publica. 2026;32(2):175-196. doi: 10.1007/s11158-025-09728-9. Epub 2025 Aug 21. PMID- 42724114 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 17 DP - 2026 TI - Therapeutic drug monitoring of zonisamide in children with epilepsy: development and validation of a precise binary prediction model. PG - 1841966 LID - 10.3389/fphar.2026.1841966 [doi] LID - 1841966 AB - OBJECTIVE: This study aimed to investigate the key factors influencing the failure to achieve steady-state trough concentrations of zonisamide in pediatric patients with epilepsy. Furthermore, we sought to construct and validate a binary machine learning prediction model for zonisamide concentration attainment to provide an objective reference for therapeutic drug monitoring in clinical practice. METHODS: A retrospective analysis was conducted on 958 pediatric patients with epilepsy who received zonisamide treatment at the Department of Neurology, Kunming Children's Hospital, from May 2022 to January 2026. Multi-dimensional feature screening was performed on the training set using spearman correlation analysis, variance inflation factor multicollinearity diagnosis, univariate analysis, lasso regression, boruta algorithm, and 500-iteration bootstrap resampling. Subsequently, 17 machine learning classification models were developed. Hyperparameter optimization was achieved through grid search combined with 10-fold cross-validation. Model performance was comprehensively evaluated in terms of discrimination, calibration, and clinical net benefit using 500-iteration bootstrap resampling. Finally, SHAPley additive exPlanations analysis and a visualized decision tree were employed to interpret the feature contribution and intrinsic decision logic of the optimal model. RESULTS: Following multi-stage screening, six core predictive variables were identified: dosage, uric acid, age, total bilirubin, vitamin D, aspartate aminotransferase, and gender. A comparative analysis of the 17 machine learning models revealed that the classification and regression tree model exhibited the best comprehensive predictive performance, demonstrating superior stability and robustness under resampling validation. The area under the curve values for the internal test set and the time-split internal validation set were 0.82 and 0.87, respectively. Calibration curves and decision curve analysis confirmed ideal calibration and a wide range of clinical net benefit. SHAPley additive exPlanations analysis and decision tree results confirmed that dosage is the primary determinant of the probability of achieving target ZNS concentrations. Sex, liver and kidney function, and nutrition-related indices collectively modulate the processes of drug absorption, metabolism, and clearance, thereby influencing the risk of failing to achieve target concentrations. CONCLUSION: The machine learning prediction model constructed using the CART algorithm can accurately and stably predict whether steady-state trough concentrations of zonisamide reach the target therapeutic range in pediatric patients with epilepsy. CI - Copyright (c) 2026 Li, Tang, Li, Zong, Li and Li. FAU - Li, Huiying AU - Li H AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. FAU - Tang, Xiaoling AU - Tang X AD - Department of Orthopedics, Kunming First People's Hospital, Kunming, China. FAU - Li, Fashuang AU - Li F AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. FAU - Zong, Jing AU - Zong J AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. FAU - Li, Yunwei AU - Li Y AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. FAU - Li, Linbo AU - Li L AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC13558151 OTO - NOTNLM OT - concentration OT - individualized dosing OT - machine learning OT - pediatric epilepsy OT - zonisamide COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 08:40 PHST- 2026/03/29 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 08:40 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 1841966 [pii] AID - 10.3389/fphar.2026.1841966 [doi] PST - epublish SO - Front Pharmacol. 2026 Aug 27;17:1841966. doi: 10.3389/fphar.2026.1841966. eCollection 2026. PMID- 42724052 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Insulin resistance evaluated by estimated glucose disposal rate and its association with cardiometabolic risk factors among adolescents in Northeast China. PG - 1853266 LID - 10.3389/fnut.2026.1853266 [doi] LID - 1853266 AB - BACKGROUND: Insulin resistance (IR) is a key factor in cardiometabolic diseases, but there are few practical ways to measure it in adolescents. The insulin sensitivity's surrogate measure, the eGDR, has not been well validated in young populations. METHODS: eGDR was determined by the use of waist circumference (WC), HbA1c levels, and hypertension status in this cross-sectional study of Chinese adolescents. Restricted cubic spline models and multivariate logistic regression were utilized to estimate associations between eGDR and cardiometabolic risk factors (CMRFs), such as dyslipidemia, hyperuricemia, and high fasting plasma glucose (FPG). The eGDR's discriminative performance was compared with traditional IR indices, such as HOMA-IR, TyG, AIP, TyG-BMI, and QUIKI. RESULTS: After confounders' adjustment, each SD raise in eGDR was linked with reduced odds of dyslipidemia (OR = 0.781, 95% CI: 0.703-0.866, p < 0.001) and hyperuricemia (OR = 0.884, 95% CI: 0.800-0.977, p = 0.016). eGDR showed negative correlations with atherogenic lipid subfractions, such as LDL-C, non-HDL-C, and triglycerides (TG), but not with total cholesterol (TC) or FPG. Subgroup analyses showed that the protective effect against dyslipidemia was stronger in participants with BMI in the >/= 85th percentile, and sex-specific differences in the associations with TG and FPG. eGDR was found to be better than traditional IR indices in discriminating clustered CMRFs. Sex-specific cut-offs for IR were determined: eGDR <8.06 mg/kg/min and <8.46 mg/kg/min for males and females, respectively. CONCLUSION: eGDR is a strong, non-invasive cardiometabolic risk indicator in adolescents, especially dyslipidemia and hyperuricemia. It can offer a feasible instrument of early risk stratification in this group. CI - Copyright (c) 2026 Wang, Yao, Li and Du. FAU - Wang, Yiwen AU - Wang Y AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Yao, Hui AU - Yao H AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Li, Ling AU - Li L AD - Department of Endocrinology, Jinghua Hospital, Shenyang, China. FAU - Du, Runyu AU - Du R AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13558436 OTO - NOTNLM OT - adolescents OT - cardiometabolic risk OT - estimated glucose disposal rate OT - insulin resistance OT - predictive performance COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 08:18 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 08:18 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.3389/fnut.2026.1853266 [doi] PST - epublish SO - Front Nutr. 2026 Aug 27;13:1853266. doi: 10.3389/fnut.2026.1853266. eCollection 2026. PMID- 42723982 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - A new potential intervention strategy to promote the "body-mind-brain" health development of Chinese children and adolescents: a scoping review. PG - 1862354 LID - 10.3389/fspor.2026.1862354 [doi] LID - 1862354 AB - OBJECTIVE: This scoping review maps the extent and nature of literature on Shaolin martial arts (SMA) and examines how direct, contextual, and indirect evidence may inform hypotheses about body-mind-brain health in children and adolescents. It does not evaluate intervention effectiveness. METHODS: Following PRISMA-ScR guidance, we searched PubMed, Web of Science, CNKI, and Wanfang Data from database inception to February 2026. Eligibility was defined by the population-concept-context framework. Records were classified as direct empirical evidence, contextual SMA literature, or indirect mechanistic evidence from related practices. Classical Chinese sources were used only to describe SMA principles and cultural context, not as evidence of health outcomes. RESULTS: Twelve of the 13 included sources were contextual publications on SMA history, philosophy, education, or dissemination, and only one examined Shaolin boxing in children aged 8-10 years. The broader literature on martial arts, tai chi, qigong, meditation, and physical activity provides only indirect support for proposed physical, psychological, and cognitive mechanisms. No direct evidence currently establishes that SMA reduces anxiety or depression, improves executive function, alters brain activation, or induces neuroplasticity in children and adolescents. CONCLUSION: The current literature supports SMA as a culturally grounded candidate for future intervention development, but not as an empirically validated health intervention for children and adolescents. Feasibility studies and well-designed controlled trials with standardized SMA protocols and prespecified physical, mental-health, cognitive, and neurobiological outcomes are required before effectiveness claims can be made. CI - (c) 2026 Jin, Qi, Zhang, Yang, Shi and Chen. FAU - Jin, Long AU - Jin L AD - School of Physical Education and Sport, Henan University, Kaifeng, China. FAU - Qi, Kai AU - Qi K AD - School of Sport and Brain Health, Nanjing Sport Institute, Nanjing, China. AD - Gdansk University of Physical Education and Sport, Gdansk, Poland. FAU - Zhang, Zehao AU - Zhang Z AD - School of Physical Education and Sport, Henan University, Kaifeng, China. FAU - Yang, Jia AU - Yang J AD - School of Sport and Brain Health, Nanjing Sport Institute, Nanjing, China. AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Shi, Yifan AU - Shi Y AD - School of Sport and Brain Health, Nanjing Sport Institute, Nanjing, China. AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Chen, Aiguo AU - Chen A AD - School of Sport and Brain Health, Nanjing Sport Institute, Nanjing, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260827 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13558168 OTO - NOTNLM OT - Shaolin martial arts OT - adolescents OT - body OT - brain OT - children OT - health OT - intervention strategy OT - mind COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 07:39 PHST- 2026/04/22 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 07:39 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.3389/fspor.2026.1862354 [doi] PST - epublish SO - Front Sports Act Living. 2026 Aug 27;8:1862354. doi: 10.3389/fspor.2026.1862354. eCollection 2026. PMID- 42723824 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260912 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Distinct metabolic phenotypes in adolescents with obesity identified by unsupervised learning: associations with insulin resistance and resting energy expenditure. PG - 1875870 LID - 10.3389/fendo.2026.1875870 [doi] LID - 1875870 AB - BACKGROUND: Pediatric obesity is characterized by substantial metabolic heterogeneity, including adiposity, insulin resistance, inflammation, and energy metabolism. Traditional categorical classifications may inadequately capture this complexity. Objective: To identify clinically meaningful metabolic phenotypes using unsupervised clustering and to compare the statistical performance and clinical interpretability of two- and three-cluster solutions. METHODS: In this cross-sectional study, 758 children and adolescents with obesity underwent anthropometric, biochemical, and indirect calorimetry assessments. Fat-free mass was estimated using validated bioimpedance-based equations, and fat-free mass index (FFMI) was standardized before clustering. K-means clustering (k = 2 and k = 3) was performed using FFMI z-score, BMI-SDS, HOMA-IR, triglycerides, and HDL-cholesterol. Cluster validity was assessed using the Silhouette, Elbow, Davies-Bouldin index, Calinski-Harabasz index, and Gap statistic methods. Validation employed variables not included in clustering, such as glucose-insulin dynamics, inflammatory and hepatic markers, blood pressure, respiratory quotient, and resting energy expenditure (REE). Group comparisons were performed using Kruskal-Wallis and Dunn's post-hoc tests with false discovery rate correction. RESULTS: Both clustering solutions demonstrated significant separation across metabolic domains. The two-cluster model identified metabolically favourable and unfavourable phenotypes differing in adiposity, insulin resistance, inflammatory burden, hepatic markers, blood pressure, and REE. The three-cluster solution revealed a more granular metabolic stratification with an intermediate phenotype characterized by partial metabolic impairment. Validation confirmed robust differences across physiological variables (all FDR-adjusted p < 0.05). Although the two-cluster solution showed slightly superior internal validity, the three-cluster model provided greater clinical granularity and phenotypic resolution. CONCLUSIONS: Unsupervised clustering identified biologically coherent metabolic phenotypes in pediatric obesity. While the two-cluster solution provided statistically robust stratification, the three-cluster configuration captured a broader spectrum of metabolic heterogeneity and risk profiles, supporting the application of higher-resolution phenotyping approaches in pediatric endocrinology and metabolic risk assessment. CI - Copyright (c) 2026 Sonza, Tamini, Bondesan, Caroli, Abbruzzese and Sartorio. FAU - Sonza, Anelise AU - Sonza A AD - Centro de Ciencias da Saude e do Esporte (CEFID), Department of Physical Therapy, Programa de Pos-Graduacao em Ciencias do Movimento Humano (PPGCMH), Universidade do Estado de Santa Catarina (UDESC), Florianopolis, Brazil. AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Tamini, Sofia AU - Tamini S AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Bondesan, Adele AU - Bondesan A AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Caroli, Diana AU - Caroli D AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Abbruzzese, Laura AU - Abbruzzese L AD - Division of Auxology, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Sartorio, Alessandro AU - Sartorio A AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. AD - Division of Auxology, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Insulin Resistance/physiology MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - Phenotype MH - *Energy Metabolism/physiology MH - Male MH - *Pediatric Obesity/metabolism MH - Child MH - *Unsupervised Machine Learning MH - Clustering Algorithms MH - Cluster Analysis MH - Body Mass Index PMC - PMC13557994 OTO - NOTNLM OT - clustering analysis OT - energy metabolism OT - insulin resistance OT - metabolic phenotyping OT - obesity OT - pediatric endocrinology COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 06:04 PHST- 2026/05/08 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 06:04 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.3389/fendo.2026.1875870 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 27;17:1875870. doi: 10.3389/fendo.2026.1875870. eCollection 2026. PMID- 42723747 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Preoperative prognostic nutritional index and in-hospital mortality in neonates undergoing cardiac surgery for congenital heart disease: a single-center retrospective study. PG - 1860048 LID - 10.3389/fnut.2026.1860048 [doi] LID - 1860048 AB - BACKGROUND: Neonates undergoing cardiac surgery for congenital heart disease (CHD) represent one of the highest-risk subpopulations in pediatric cardiac surgery. Preoperative nutritional and immune reserve may substantially influence perioperative resilience, yet practical neonatal-specific nutritional risk markers remain insufficiently defined. OBJECTIVE: To evaluate the association between preoperative prognostic nutritional index (PNI) and in-hospital mortality in neonates undergoing cardiac surgery for CHD, and to explore a neonatal-specific cutoff value for early risk stratification. METHODS: This retrospective single-center cohort study included 433 neonates ( /= 20 indicating elevated susceptibility. Dietary behaviors during the previous 6 months were self-reported and categorized into index-based, macronutrient-focused, pattern/lifestyle, and special or plant-based diets. Multivariable logistic regression models and general linear models were used to examine associations between dietary variables and eating disorder susceptibility and symptom severity. RESULTS: Among the 188 participants included in the primary analysis, 90 (47.9%) participants were susceptible to eating disorders. Participants who had followed any dietary regimen in the previous 6 months were significantly more likely to exhibit eating disorder susceptibility compared with non-dieters (p < 0.001). DISCUSSION: These findings suggest that recent engagement in dieting, rather than specific dietary characteristics, is associated with increased eating disorder susceptibility among adults in Riyadh. Public health efforts should emphasize balanced, evidence-based dietary guidance and increased awareness of the potential psychological risks of unsupervised dieting. Longitudinal research is needed to clarify temporal relationships and causal pathways. CI - (c) 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Aldahash, Rehab A AU - Aldahash RA AUID- ORCID: 0000-0003-2703-3585 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alturki, Haifa Y AU - Alturki HY AUID- ORCID: 0009-0000-6048-8528 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alonazi, Shahad G AU - Alonazi SG AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Dabbour, Joury AU - Dabbour J AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Aldossari, Shahad M AU - Aldossari SM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Aldhfayan, Sara AU - Aldhfayan S AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng GR - PNURSP2026R533/Princess Nourah bint Abdulrahman University Researchers Supporting Project/ GR - PNURSP2026R533/Princess Nourah Bint Abdulrahman University/ PT - Journal Article PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Adult MH - *Feeding and Eating Disorders/epidemiology MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Adolescent MH - *Diet MH - Middle Aged MH - *Feeding Behavior/physiology MH - Disease Susceptibility PMC - PMC13563051 OTO - NOTNLM OT - Eating Attitudes Test (EAT-26) OT - Saudi Arabia OT - dietary patterns OT - dieting behavior OT - eating disorder susceptibility COIS- The authors declare no conflicts of interest. EDAT- 2026/09/11 05:36 MHDA- 2026/09/11 05:37 PMCR- 2026/09/10 CRDT- 2026/09/11 02:43 PHST- 2026/07/27 00:00 [revised] PHST- 2026/01/21 00:00 [received] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/11 05:37 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/11 02:43 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - BRB371688 [pii] AID - 10.1002/brb3.71688 [doi] PST - ppublish SO - Brain Behav. 2026 Sep;16(9):e71688. doi: 10.1002/brb3.71688. PMID- 42722762 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 10 DP - 2026 Sep 10 TI - Association between insulin resistance and obstructive sleep apnea in non-diabetic children with obesity. LID - 739 [pii] LID - 10.1007/s00431-026-07395-3 [doi] AB - Although several studies have demonstrated an independent association between obstructive sleep apnea (OSA) and insulin resistance, the evidence remains inconsistent. We aimed to investigate the relationship between the presence and severity of OSA and insulin resistance in non-diabetic children with obesity and to explore the potential role of homeostasis model assessment-insulin resistance index (HOMA-IR) in identifying children at higher risk for OSA. Children with obesity aged 6-18 years who underwent polysomnography were retrospectively analyzed. Patients with diabetes, neuromuscular disorders, craniofacial anomalies, or those receiving treatment affecting insulin sensitivity were excluded. Age, sex, BMI, and oral glucose tolerance test (OGTT) results were extracted from medical records, and HOMA-IR was calculated. Patients were divided into two groups based on their obstructive apnea-hypopnea index (OAHI): < 2 and >/= 2 events/h. ROC analysis was performed for HOMA-IR to determine the optimal cutoff value for identifying patients with OSA. A total of 90 children with obesity were enrolled, among whom 39 (43.3%) had OSA. The groups were comparable in terms of age and sex. Median HOMA-IR values were significantly higher in the OSA group (p = 0.014). Total OAHI showed moderately positive correlation with HOMA-IR (rho = 0.325, p = 0.002), and baseline insulin levels measured during OGTT (rho = 0.323, p = 0.002). In multiple linear regression analysis, HOMA-IR remained independently associated with OSA severity after adjustment for age, sex, BMI z-score, sleep efficiency, and pubertal status (beta = 0.691, p = 0.025). ROC analysis identified a HOMA-IR cutoff of 3.39, with 72% sensitivity and 59% specificity for OSA. CONCLUSION: HOMA-IR was independently associated with OSA severity in children with obesity, suggesting that insulin resistance may serve as a useful adjunct marker for identifying patients at higher risk and prioritizing PSG evaluation. WHAT IS KNOWN: * Childhood obesity is strongly associated with both obstructive sleep apnea (OSA) and insulin resistance. Whether insulin resistance contributes to OSA risk beyond the effect of obesity remains controversial. * Access to polysomnography (PSG) is limited, creating an unmet need for practical tools to identify children at greatest risk for OSA. WHAT IS NEW: * To our knowledge, this is the first pediatric study to evaluate HOMA-IR as a tool for identifying children with obesity at increased risk of obstructive sleep apnea and to propose a clinically applicable HOMA-IR threshold for prioritizing polysomnography referral. * In non-diabetic children with obesity, insulin resistance was independently associated with OSA severity, regardless of obesity, pubertal status, and other clinically relevant confounders. Children with HOMA-IR >/= 3.39 had a substantially greater burden of obstructive sleep apnea. These findings support HOMA-IR as a simple, widely available biomarker that could help prioritize children with obesity for PSG evaluation and improve risk stratification in pediatric sleep medicine. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Sunman, Birce AU - Sunman B AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. bircesunman@gmail.com. AD - Department of Pediatric Pulmonology, School of Medicine, Hacettepe University, Ihsan Dogramaci Children's Hospital, 06230, Ankara, Turkey. bircesunman@gmail.com. FAU - Alboga, Didem AU - Alboga D AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Akgul Erdal, Meltem AU - Akgul Erdal M AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Demir, Havva Ipek AU - Demir HI AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Senkalfa, Burcu AU - Senkalfa B AD - Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Vuralli, Dogus AU - Vuralli D AD - Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Emiralioglu, Nagehan AU - Emiralioglu N AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Gonc, Nazli AU - Gonc N AD - Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Ozon, Alev AU - Ozon A AD - Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Yalcin, Ebru AU - Yalcin E AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Dogru, Deniz AU - Dogru D AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Ozcelik, Ugur AU - Ozcelik U AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260910 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis/complications/etiology MH - *Insulin Resistance MH - Child MH - Male MH - Female MH - Adolescent MH - Retrospective Studies MH - Polysomnography MH - *Pediatric Obesity/complications MH - Severity of Illness Index MH - Glucose Tolerance Test MH - Risk Factors MH - ROC Curve MH - Body Mass Index OTO - NOTNLM OT - AHI OT - Child OT - Insulin resistance OT - Sleep apnea COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethics Committee of Hacettepe University (Approval No: GO 22/138) and conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from the parents or legal guardians of all participants, and assent was obtained from children when appropriate. Consent for publication: All authors have read and approved the final manuscript and consent to its publication. Competing interests: The authors declare no competing interests. EDAT- 2026/09/11 05:36 MHDA- 2026/09/11 05:37 CRDT- 2026/09/10 23:55 PHST- 2026/06/22 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/08/17 00:00 [revised] PHST- 2026/09/11 05:37 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/10 23:55 [entrez] AID - 10.1007/s00431-026-07395-3 [pii] AID - 10.1007/s00431-026-07395-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Sep 10;185(10):739. doi: 10.1007/s00431-026-07395-3. PMID- 42722725 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260917 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Sep 8 TI - Probability of predicting dietary pattern adherence among primary schoolchildren based on socio-demographic data, anthropometric parameters, physical activity levels, and nutritional knowledge. LID - 10.1038/s41598-026-70753-6 [doi] LID - 28356 AB - Adolescence is a critical period of rapid physical and psychosocial development during which eating behaviours are influenced by a variety of internal and external factors. Understanding these relationships is crucial for preventing unhealthy dietary habits and for effective nutrition education. This cross-sectional study included 7,763 schoolchildren aged 10-12 (49.2% boys, 50.8% girls) from Polish schools. The validated questionnaire was used to assess children's nutritional knowledge, dietary habits, and physical activity. Standard anthropometric measurements (body weight, height, waist circumference) were taken, and BMI, WHtR, RFMp, and TMI were calculated. Descriptive statistics were used for sample characteristics. Principal component analysis (PCA) with varimax rotation (MSA = 0.796) was used to identify dietary patterns. Logistic regression modeled predictors of belonging to the highest tertile. Three dietary patterns were identified: Salty-Sweet, Plant-Dairy, and Protein. Children classified as overweight according to the RFMp index and children who were very physically active showed less adherence to the Salty-Sweet Pattern. Schoolchildren who were underweight according to the BMI index and those with low nutritional knowledge were more likely to follow the Salty-Sweet Pattern. Girls, children with an elevated waist-to-hip ratio (WHtR), and very physically active children were more likely to be in the third tertile of the Plant-Dairy Pattern. Schoolchildren with low nutritional knowledge showed less adherence to this pattern. Girls showed less adherence to the protein pattern, whereas underweight children and those who were very physically active showed greater adherence. The dietary patterns of schoolchildren are interrelated, and knowledge of nutrition and physical activity is the main modifiable determinant. These factors can be utilised when developing strategies for regularly assessing nutritional status and providing specialist advice to schoolchildrens, their families, and teachers. CI - (c) 2026. The Author(s). FAU - Drywien, Malgorzata Ewa AU - Drywien ME AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Czarniecka-Skubina, Ewa AU - Czarniecka-Skubina E AD - Department of Food Gastronomy and Food Hygiene, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Nowoursynowska st. 159c, Warsaw, 02-787, Poland. ewa_czarniecka-skubina@sggw.edu.pl. FAU - Hamulka, Jadwiga AU - Hamulka J AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Gebski, Jerzy AU - Gebski J AD - Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Januszko, Olga AU - Januszko O AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Sadowska, Joanna AU - Sadowska J AD - Department of Applied Microbiology and Human Nutrition Physiology, West Pomeranian University of Technology in Szczecin, Szczecin, Poland. FAU - Gutkowska, Krystyna AU - Gutkowska K AD - Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. LA - eng GR - MEiN/2022/DPI/96 of 7 March 2022/Polish Ministry of Education and Science/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260908 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Child MH - *Exercise MH - Male MH - *Feeding Behavior MH - Anthropometry MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Body Mass Index MH - Poland MH - *Diet MH - Surveys and Questionnaires PMC - PMC13562532 OTO - NOTNLM OT - Anthropometric data OT - Dietary patterns OT - Nutritional knowledge OT - Physical activity OT - Schoolchildren OT - Socio-demographic factors COIS- Declarations. Competing interests: Ewa Czarniecka-Skubina - Editor Board Member. Implications and contribution: This study has implications for educational and public health policies targeting young people. Adolescents follow distinct dietary patterns shaped by modifiable factors. These findings may inform strategies to prevent nutritional deficiencies through regular dietary assessment and targeted guidance for schoolchildrenadolescents, families, and educators. EDAT- 2026/09/11 05:36 MHDA- 2026/09/11 05:37 PMCR- 2026/09/08 CRDT- 2026/09/10 23:46 PHST- 2026/07/03 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/11 05:37 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/10 23:46 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.1038/s41598-026-70753-6 [pii] AID - 70753 [pii] AID - 10.1038/s41598-026-70753-6 [doi] PST - epublish SO - Sci Rep. 2026 Sep 8;16(1):28356. doi: 10.1038/s41598-026-70753-6. PMID- 42722700 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261005 IS - 2092-6413 (Electronic) IS - 1226-3613 (Print) IS - 1226-3613 (Linking) VI - 58 IP - 9 DP - 2026 Sep TI - Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway. PG - 3113-3126 LID - 10.1038/s12276-026-01828-7 [doi] AB - Obesity, marked by visceral fat accumulation, has a complex relationship with the gut microbiome that impacts body weight and fat accumulation. However, previous studies did not account for fat distribution, reflecting only overall fat mass, leaving specifics of this relationship partially understood. Here we analyzed the mechanistic links between visceral fat and the microbiome in a large cohort of healthy Koreans. Using permutational multivariate analysis of variance and prediction modeling, we examined associations between microbial profiles and metabolic variables including insulin, triglycerides, waist circumference and visceral fat. The strongest correlations were noted with specific enterotypes. Shotgun sequencing revealed that visceral fat is linked to the glycogen synthesis pathway influenced by Dorea longicatena and Bifidobacterium adolescentis. This suggests that these specific microbial signatures and their associated functional potential play a role in visceral fat-related obesity. To validate these findings, we conducted an in vivo study using diet-induced obesity mouse model. Oral administration of D. longicatena or B. adolescentis significantly promoted body weight gain and fat mass expansion and induced hepatic lipogenic gene upregulation. The prevalence of these strains in Korean and American populations highlights their global relevance, contributing to the development of personalized treatments and advanced health strategies. CI - (c) 2026. The Author(s). FAU - Kim, Nam-Eun AU - Kim NE AUID- ORCID: 0000-0003-4155-2584 AD - Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea. AD - Department of Medical Informatics, Jeonbuk National University Medical School, Jeonju, Republic of Korea. FAU - Cho, Beomki AU - Cho B AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Kim, Yunjae AU - Kim Y AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Kim, Gihyeon AU - Kim G AD - Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Republic of Korea. AD - Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Genome and Company, Gyeonggi-do, Republic of Korea. FAU - Yie, Ga-Eun AU - Yie GE AD - Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea. FAU - Kim, Haeon AU - Kim H AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Park, Jaesung AU - Park J AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Kim, Hyun AU - Kim H AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Jeong, Chanyoung AU - Jeong C AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Lee, Minji AU - Lee M AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Joo, Yanghyun AU - Joo Y AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Lim, Sua AU - Lim S AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Park, Sihyeon AU - Park S AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Hong, Yeji AU - Hong Y AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Min, Kyungchan AU - Min K AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Cho, Belong AU - Cho B AD - Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea. AD - Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. FAU - Yun, Jae Moon AU - Yun JM AD - Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea. AD - Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. FAU - Jung, Eun Sung AU - Jung ES AD - HEM Pharma, Gyeonggi-do, Republic of Korea. FAU - Ji, Yosep AU - Ji Y AD - HEM Pharma, Gyeonggi-do, Republic of Korea. FAU - Cho, Seongbeom AU - Cho S AD - College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea. FAU - Seong, Je Kyung AU - Seong JK AD - Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. AD - Korea Model Animal Priority Center, Seoul National University, Seoul, Republic of Korea. FAU - Park, Hansoo AU - Park H AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. hspark27@gist.ac.kr. AD - Genome and Company, Gyeonggi-do, Republic of Korea. hspark27@gist.ac.kr. FAU - Park, Jin-Ho AU - Park JH AD - Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea. pjhn@snu.ac.kr. AD - Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. pjhn@snu.ac.kr. FAU - Won, Sungho AU - Won S AUID- ORCID: 0000-0001-5751-5089 AD - Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea. won1@snu.ac.kr. AD - Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea. won1@snu.ac.kr. AD - RexSoft Corp, Seoul, Republic of Korea. won1@snu.ac.kr. AD - Department of Public Health Sciences, Seoul National University, Seoul, Republic of Korea. won1@snu.ac.kr. LA - eng GR - 2022R1A2C2008976/Ministry of Science, ICT and Future Planning (MSIP)/ GR - RS-2023-00228315/Ministry of Science, ICT and Future Planning (MSIP)/ GR - 2024-ER2108-00/Ministry of Health, Welfare and Family Affairs | Korea National Institute of Health (KNIH)/ GR - RS-2021-NR060088/National Research Foundation of Korea (NRF)/ GR - KSC-2024-CRE-0514/National Research Foundation of Korea (NRF)/ PT - Journal Article DEP - 20260910 PL - United States TA - Exp Mol Med JT - Experimental & molecular medicine JID - 9607880 RN - 9005-79-2 (Glycogen) SB - IM MH - Animals MH - *Intra-Abdominal Fat/metabolism MH - *Gastrointestinal Microbiome MH - Humans MH - Male MH - *Glycogen/biosynthesis MH - Mice MH - *Obesity/metabolism/microbiology/etiology MH - Female MH - *Bacteria/classification/genetics MH - Bifidobacterium adolescentis PMC - PMC13633279 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/09/11 05:36 MHDA- 2026/10/03 05:33 PMCR- 2026/09/10 CRDT- 2026/09/10 23:43 PHST- 2025/09/11 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/05/22 00:00 [revised] PHST- 2026/10/03 05:33 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/10 23:43 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - 10.1038/s12276-026-01828-7 [pii] AID - 1828 [pii] AID - 10.1038/s12276-026-01828-7 [doi] PST - ppublish SO - Exp Mol Med. 2026 Sep;58(9):3113-3126. doi: 10.1038/s12276-026-01828-7. Epub 2026 Sep 10. PMID- 42721609 OWN - NLM STAT- Publisher LR - 20260910 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 153 DP - 2026 Aug 18 TI - Not only bowel: opportunistic assessment of sarcopenia in pediatric ulcerative colitis patients undergoing magnetic resonance enterography. PG - 113402 LID - S0899-9007(26)00309-6 [pii] LID - 10.1016/j.nut.2026.113402 [doi] AB - PURPOSE: Malnutrition and sarcopenia are under-recognized complications in pediatric inflammatory bowel disease, with an understudied interrelationship. This exploratory study aimed to estimate the prevalence of sarcopenia in children with newly diagnosed Ulcerative Colitis (UC) and to investigate associations between opportunistically MRE-derived muscle metrics and clinical, laboratory, and endoscopic disease activity. MATERIALS AND METHODS: Retrospective enrollment of 20 children aged 6-18 years who were ultimately diagnosed with UC and had undergone MRE as part of the systematic initial diagnostic work-up for suspected pediatric IBD. Total psoas muscle area (tPMA) was measured on axial T2-weighted images at the L3 vertebral level and used as a sarcopenia biomarker: "at risk of sarcopenia" with tPMA <10th percentile, and with "severe sarcopenia" /=0.70, 0.80, and 0.90). Sensitivity analyses using the combined durations of sessions and glances produced similar conservative monitoring-day recommendations. RESULTS: Single-day ICCs were 0.69 (95% CI 0.63-0.76) for Android Chronicle and 0.71 (95% CI 0.65-0.77) for iOS Screenshot data. Point-estimate projections indicated that 2 monitoring days were sufficient to achieve an ICC>/=0.80 for both data sources. Using the more conservative criterion that the lower bound of the projected 95% CI exceeded 0.80, 3 monitoring days were required for both Android and iOS data. Screen time was significantly lower on weekends than on weekdays, suggesting that monitoring periods should include at least 1 weekend day. CONCLUSIONS: Among caregivers of preschool-aged children, relatively short objective monitoring periods may provide reliable estimates of average daily smartphone screen time within a 7-day monitoring period. Two monitoring days were sufficient under point-estimate projections, whereas 3 days were required using a conservative lower-bound criterion. These findings support the feasibility of brief smartphone monitoring protocols for estimating the 7-day average duration, while emphasizing the importance of including weekend representation and avoiding the extension of these estimates to longer-term habitual smartphone behavior or screen time metrics beyond duration without further evidence. CI - (c) Joshua Culverhouse, Taylor Adair, Meghan Restino, Heidi M Weeks, Jenny S Radesky, R Glenn Weaver, Sarah Burkart, Hannah Parker, Olivia L Finnegan, Anthony J Holmes, Keagan Kiely, Rahul Ghosal, Srihari Nelakuditi, Michael W Beets, Bridget Armstrong. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Culverhouse, Joshua AU - Culverhouse J AUID- ORCID: 0000-0001-5345-5760 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Adair, Taylor AU - Adair T AUID- ORCID: 0009-0008-8045-9984 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Restino, Meghan AU - Restino M AUID- ORCID: 0009-0004-1557-2471 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Weeks, Heidi M AU - Weeks HM AUID- ORCID: 0000-0003-3467-7987 AD - University of Michigan School of Public Health, Ann Arbor, MI, United States. FAU - Radesky, Jenny S AU - Radesky JS AUID- ORCID: 0000-0002-7721-7350 AD - University of Michigan Medical School, Ann Arbor, MI, United States. FAU - Weaver, R Glenn AU - Weaver RG AUID- ORCID: 0000-0001-5889-974X AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Burkart, Sarah AU - Burkart S AUID- ORCID: 0000-0002-0840-1680 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Parker, Hannah AU - Parker H AUID- ORCID: 0000-0003-4197-7224 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Finnegan, Olivia L AU - Finnegan OL AUID- ORCID: 0000-0003-0625-1479 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Holmes, Anthony J AU - Holmes AJ AUID- ORCID: 0000-0003-4711-629X AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Kiely, Keagan AU - Kiely K AUID- ORCID: 0009-0008-0015-3484 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Ghosal, Rahul AU - Ghosal R AUID- ORCID: 0000-0003-0939-4731 AD - Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, United States. FAU - Nelakuditi, Srihari AU - Nelakuditi S AUID- ORCID: 0000-0001-5990-394X AD - Department of Computer Science and Engineering, University of South Carolina, Columbia, SC, United States. FAU - Beets, Michael W AU - Beets MW AUID- ORCID: 0000-0001-6728-6742 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Armstrong, Bridget AU - Armstrong B AUID- ORCID: 0000-0002-1909-8170 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. LA - eng GR - P20 GM130420/GM/NIGMS NIH HHS/United States GR - R01 HD112311/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260910 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data/instrumentation/standards MH - Reproducibility of Results MH - *Caregivers/statistics & numerical data/psychology MH - Child, Preschool MH - *Screen Time MH - Female MH - Male MH - Time Factors PMC - PMC13561401 OTO - NOTNLM OT - passive sensing OT - reliability OT - sampling duration OT - screen time OT - smartphone COIS- Conflicts of Interest: The authors declare no conflicts of interest. EDAT- 2026/09/10 17:42 MHDA- 2026/09/10 17:43 PMCR- 2026/09/10 CRDT- 2026/09/10 15:53 PHST- 2025/08/22 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/10 17:43 [medline] PHST- 2026/09/10 17:42 [pubmed] PHST- 2026/09/10 15:53 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - v14i1e82846 [pii] AID - 82846 [pii] AID - 10.2196/82846 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Sep 10;14:e82846. doi: 10.2196/82846. PMID- 42721394 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260910 LR - 20260910 IS - 2757-6256 (Print) IS - 2757-6256 (Linking) VI - 61 IP - 9 DP - 2026 Jul 6 TI - Does Body Fat Mass Influence the Timing of Puberty in Boys with Constitutional Delay of Growth and Puberty? PG - 815-821 LID - 10.65717/TurkArchPediatr.2026.25450 [doi] AB - OBJECTIVE: In girls, a strong relationship exists between body fat percentage (BFP) and pubertal development, with a critical fat threshold considered essential for the initiation of puberty. In contrast, research addressing the impact of body composition on the timing of puberty in boys remains limited, and the available findings are inconsistent. To evaluate the association between body composition and delayed pubertal development in boys with constitutional delay of growth and puberty (CDGP) compared with healthy peers. METHODS: Thirty-one boys with CDGP and 31 age-matched healthy males (Tanner stage 2-4) were included. Body composition was assessed using bioelectrical impedance analysis. Body fat percentage (BFP), fat mass (FM), fat-free mass (FFM), fat mass index (FMI), and fat-free mass index (FFMI) were evaluated. A BFP value of 17% was used as a descriptive reference rather than a validated biological cut-off. RESULTS: The mean chronological age was 14.1 +/- 0.5 years in the CDGP group and 13.9 +/- 1.1 years in the control group (P = .4). Compared with controls, boys with CDGP had significantly lower body mass index (BMI) standard deviation (SD) scores (P = .01). FM and FM SD scores were also significantly lower (both P = .002), and BFP was reduced (P = .03). No significant difference in BFP SD score was observed between groups (P > .05). The FFM/FM ratio was higher in the CDGP group (P = .04). FMI, FMI SD score, FFMI, and FFMI SD score were all significantly lower in boys with CDGP (P = .02, P = .02, P = .009, and P = .009, respectively). A BFP below 17% was observed in 58.1% of CDGP patients compared with 9.7% of controls (P < .001). CONCLUSION: Lower BMI, FM, and FFMI were associated with delayed pubertal onset in boys with CDGP, suggesting a potential relationship between reduced adiposity, lean mass, and the timing of pubertal development. CI - Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Copyright (c) Author(s) - Available online at https://turkarchpediatr.org/EN. Published by the Turkish Pediatrics Association. FAU - Kagizmanli, Gozde Akin AU - Kagizmanli GA AUID- ORCID: 0000-0002-6158-9002 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. FAU - Demir, Korcan AU - Demir K AUID- ORCID: 0000-0002-8334-2422 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. FAU - Bober, Ece AU - Bober E AUID- ORCID: 0000-0001-8828-0892 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. FAU - Abaci, Ayhan AU - Abaci A AUID- ORCID: 0000-0002-1812-0321 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. LA - eng PT - Journal Article DEP - 20260706 PL - Turkey TA - Turk Arch Pediatr JT - Turkish archives of pediatrics JID - 101776822 OTO - NOTNLM OT - Adiposity OT - body composition OT - delayed puberty OT - fat mass OT - male OT - pubertal onset COIS- The authors have no conflicts of interest to declare. EDAT- 2026/09/10 17:42 MHDA- 2026/09/10 17:43 CRDT- 2026/09/10 15:53 PHST- 2026/09/10 17:43 [medline] PHST- 2026/09/10 17:42 [pubmed] PHST- 2026/09/10 15:53 [entrez] AID - 10.65717/TurkArchPediatr.2026.25450 [doi] PST - epublish SO - Turk Arch Pediatr. 2026 Jul 6;61(9):815-821. doi: 10.65717/TurkArchPediatr.2026.25450. PMID- 42721389 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260910 LR - 20260910 IS - 2757-6256 (Print) IS - 2757-6256 (Linking) VI - 61 IP - 9 DP - 2026 Sep 1 TI - Pediatric Sports Medicine: A Comprehensive Review. PG - 774-784 LID - 10.65717/TurkArchPediatr.2026.26070 [doi] AB - As participation of children in exercise and organized sports increases worldwide, the health care needs of young athletes differ substantially from those of adults due to age-specific physiological, biomechanical, and psychosocial characteristics related to growth and development. Pediatric Sports Medicine (PSM) is a pediatric-based, multidisciplinary subspecialty that encompasses preparticipation physical evaluation (PPE), exercise prescription, management of sports injuries and overuse syndromes, sport-related concussion, heat-related illnesses, assessment of sudden cardiac event risk, relative energy deficiency in sport (RED-S), planning safe sports participation for children with chronic medical conditions, and safeguarding in sport. In the United States, PSM is formally structured through pediatric-based fellowship training and board certification, whereas Europe lacks a standardized model and relies on heterogeneous approaches integrating pediatrics, sports medicine, and rehabilitation. In Turkiye, sports medicine training remains largely adult-oriented. Given that pediatric subspecialty training is strictly based on prior pediatric specialization and that pediatricians are routinely consulted for comprehensive medical evaluations, the absence of a pediatric-based PSM structure has resulted in notable gaps in pediatric-specific PPE standardization, early sport specialization and load management, RED-S screening, integration of school-club-health care systems, and the health care component of safeguarding policies. This narrative review presents a literature-based synthesis of the conceptual foundations and clinical and public health rationale of PSM, summarizes relevant international guidelines and consensus statements, and proposes a feasible framework for its implementation in Turkiye, where this subspecialty has not yet been established. CI - Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Copyright (c) Author(s) - Available online at https://turkarchpediatr.org/EN. Published by the Turkish Pediatrics Association. FAU - Akkus, Abdullah AU - Akkus A AUID- ORCID: 0000-0002-0642-8759 AD - Department of Pediatrics, Necmettin Erbakan University Faculty of Medicine, Konya, Turkiye. FAU - Aslan, Huseyin AU - Aslan H AUID- ORCID: 0000-0001-7138-0643 AD - Department of Physical Education, Selcuk University Faculty of Sport Science, Konya, Turkiye. FAU - Sarac, Ugur AU - Sarac U AUID- ORCID: 0009-0000-0652-5834 AD - Department of Pediatrics, Necmettin Erbakan University Faculty of Medicine, Konya, Turkiye. FAU - Yilmaz, Resul AU - Yilmaz R AUID- ORCID: 0000-0002-5527-2893 AD - Department of Anesthesiology, Necmettin Erbakan University Faculty of Medicine, Konya, Turkiye. FAU - Dursun, Sumeyye AU - Dursun S AUID- ORCID: 0009-0005-3764-2773 AD - Department of Pediatrics, Necmettin Erbakan University Faculty of Medicine, Konya, Turkiye. FAU - Ercan, Nefise Betul AU - Ercan NB AUID- ORCID: 0000-0001-7863-831X AD - Department of Medical Education and Informatics, Necmettin Erbakan University Faculty of Medicine, Konya, Turkiye. FAU - Yucel, Mehtap AU - Yucel M AUID- ORCID: 0000-0001-6091-3205 AD - Department of Public Health, Necmettin Erbakan University Faculty of Medicine, Konya, Turkiye. FAU - Ozkaymakoglu, Ceylani AU - Ozkaymakoglu C AUID- ORCID: 0000-0003-2537-9080 AD - Department of Physical Education, Selcuk University Faculty of Sport Science, Konya, Turkiye. FAU - Tatlici, Ali AU - Tatlici A AUID- ORCID: 0000-0001-6346-0010 AD - Department of Physical Education, Selcuk University Faculty of Sport Science, Konya, Turkiye. FAU - Kilic, Ahmet Osman AU - Kilic AO AUID- ORCID: 0000-0002-3451-6764 AD - Department of Pediatrics, Necmettin Erbakan University Faculty of Medicine, Konya, Turkiye. FAU - Yazar, Abdullah AU - Yazar A AUID- ORCID: 0000-0003-0733-3943 AD - Department of Pediatrics, Necmettin Erbakan University Faculty of Medicine, Konya, Turkiye. FAU - Akin, Fatih AU - Akin F AUID- ORCID: 0000-0001-5725-3867 AD - Department of Pediatrics, Necmettin Erbakan University Faculty of Medicine, Konya, Turkiye. FAU - Koutures, Chris G AU - Koutures CG AD - Department of Pediatric Sports Medicine, AktiveKid MD Clinic, USA. LA - eng PT - Journal Article PT - Review DEP - 20260901 PL - Turkey TA - Turk Arch Pediatr JT - Turkish archives of pediatrics JID - 101776822 OTO - NOTNLM OT - Early specialization OT - Pediatric Sports Medicine OT - pediatric athlete OT - preparticipation physical evaluation COIS- The authors have no conflicts of interest to declare. However, in the interest of full transparency and in accordance with International Committee of Medical Journal Editors (ICMJE) recommendations on non-financial interests, the lead author (A.A.) discloses a relevant intellectual conflict of interest: A.A. has submitted two formal applications to the Council of Higher Education of Turkiye (YOK) for the recognition of Pediatric Sports Medicine as an official subspecialty within the Department of Child Health and Diseases; both applications were not approved, and efforts toward formal recognition are ongoing. The present manuscript is intended, in part, to contribute to the scientific and policy foundation for such an initiative. The authors wish to emphasize that this disclosure reflects not a financial stake but a professional and academic commitment to addressing a documented structural gap in pediatric athlete care in Turkiye-a commitment that, in the authors' view, constitutes a source of relevant expertise rather than bias. The scientific content of this manuscript is fully verifiable through the cited sources and stands independently of the authors' advocacy position. EDAT- 2026/09/10 17:42 MHDA- 2026/09/10 17:43 CRDT- 2026/09/10 15:53 PHST- 2026/09/10 17:43 [medline] PHST- 2026/09/10 17:42 [pubmed] PHST- 2026/09/10 15:53 [entrez] AID - 10.65717/TurkArchPediatr.2026.26070 [doi] PST - epublish SO - Turk Arch Pediatr. 2026 Sep 1;61(9):774-784. doi: 10.65717/TurkArchPediatr.2026.26070. PMID- 42720508 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260915 IS - 1460-2245 (Electronic) IS - 0957-4824 (Print) IS - 0957-4824 (Linking) VI - 41 IP - 5 DP - 2026 Sep 1 TI - A realist inspired barriers and facilitators evaluation of the co-creation process in the Youth-centred Participatory Action Project. LID - 10.1093/heapro/daag134 [doi] LID - daag134 AB - This study examined barriers and facilitators of the first phase of the co-creation process as part of the Youth-centred Participatory Action (YoPA) project, a multi-country co-creation initiative to address health inequities by engaging adolescents in Denmark, Nigeria, South Africa, and the Netherlands. Using a qualitative design informed by implementation science and realist thinking, we analysed data from 22 transcripts of semi-structured interviews with researchers, facilitators, and external stakeholders, alongside 61 logbooks from co-creation sessions. Data were coded deductively using the PROSECO process-evaluation framework, followed by the development of exploratory Context-Mechanism-Outcome configurations. Findings highlight four predominant areas shaping the co-creation process: group dynamics, partnerships, contextual influences, and resources and support. Facilitators included psychologically safe spaces, horizontal communication, consistent facilitation, strong institutional partnerships, motivation driven by purpose and belonging, and access to organizational resources and staff support. Barriers were associated with socioeconomic adversity, unstable infrastructures, logistical constraints, competing priorities, uneven engagement, and challenges in translating complex systems-thinking concepts into youth-friendly practice. Realist interpretations suggest that when structured participation, trust, and relational support were present, they activated mechanisms of ownership, agency, and sustained engagement; conversely, low-resource contexts and activities overload hindered participation, feasibility, and engagement. This study contributes empirical evidence on co-creation processes with adolescents across diverse settings. It demonstrates the combined value of the PROSECO framework and realist-inspired analysis for evaluation and understanding of how context and mechanisms shape co-creation in health-related research. Implications include the need for resourcing relational work, and designing context-sensitive strategies when conducting co-creation with adolescents. CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Souza, Maria Fernanda S AU - Souza MFS AUID- ORCID: 0000-0002-4135-8549 AD - Research Center in Sports, Physical Education, Exercise and Health (CIDEFES), Universidade Lusofona, Campo Grande, 376, Lisboa 1749-024, Portugal. AD - CIFI2D, Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido Costa 91, Porto 4200-450, Portugal. FAU - Chinapaw, Mai AU - Chinapaw M AUID- ORCID: 0000-0001-6259-2441 AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Silva, Catarina Santos AU - Silva CS AUID- ORCID: 0000-0001-9464-7064 AD - Research Center in Sports, Physical Education, Exercise and Health (CIDEFES), Universidade Lusofona, Campo Grande, 376, Lisboa 1749-024, Portugal. AD - CIFI2D, Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido Costa 91, Porto 4200-450, Portugal. FAU - Demetriadou, Leto AU - Demetriadou L AUID- ORCID: 0000-0002-2620-9932 AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Madsen, Line AU - Madsen L AUID- ORCID: 0009-0005-4539-3842 AD - Department of Sports Science and Biomechanics, Faculty of Health Sciences, Southern Denmark University, Campusvej, 55, Odense M DK52-30, Denmark. FAU - Maluleke, Vongani AU - Maluleke V AUID- ORCID: 0009-0004-8426-4632 AD - Department of Paediatrics, School of Clinical Medicine, University of the Witwatersrand, Wits Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa. FAU - Ndwandwe, Lethukuthula AU - Ndwandwe L AUID- ORCID: 0009-0005-1373-960X AD - Department of Paediatrics, School of Clinical Medicine, University of the Witwatersrand, Wits Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa. FAU - Okafor, Anita AU - Okafor A AUID- ORCID: 0000-0003-4510-1553 AD - Department of Physiotherapy, Redeemer's University, off Gbongan - Oshogbo Road, Ede, Osun State 232101, Nigeria. FAU - Ogunleye, Adefunke AU - Ogunleye A AUID- ORCID: 0009-0008-2821-6811 AD - Gender and Education Department, Value Re-Orientation for Community Enhancement (VARCE), 25, Bola Famoyin Lane, Dada State, Osogbo, Osun State 230261, Nigeria. FAU - Vargas, Jesse AU - Vargas J AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Longworth, Giuliana AU - Longworth G AUID- ORCID: 0000-0001-9063-4821 AD - School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Cowcaddens Road, Glasgow G4 0BA, United Kingdom. FAU - Altenburg, Teatske AU - Altenburg T AUID- ORCID: 0000-0002-8764-5631 AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Klaufus, Leonie AU - Klaufus L AUID- ORCID: 0000-0001-9878-3530 AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Omotoso, Dayo AU - Omotoso D AUID- ORCID: 0000-0002-4467-2955 AD - Department of Anatomy, Redeemer's University, off Gbongan - Oshogbo Road, Ede, Osun State 232101, Nigeria. FAU - Oyeyemi, Adewale AU - Oyeyemi A AUID- ORCID: 0000-0002-3737-2911 AD - College of Health Solutions, Arizona State University, 550 N, 3rd Street, Health North Building, Suite 501, Phoenix, AZ 85004, United States. FAU - Ware, Lisa AU - Ware L AUID- ORCID: 0000-0002-9762-4017 AD - Department of Paediatrics, School of Clinical Medicine, University of the Witwatersrand, Wits Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa. FAU - Palmeira, Antonio AU - Palmeira A AUID- ORCID: 0000-0001-6508-0599 AD - Research Center in Sports, Physical Education, Exercise and Health (CIDEFES), Universidade Lusofona, Campo Grande, 376, Lisboa 1749-024, Portugal. AD - CIFI2D, Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido Costa 91, Porto 4200-450, Portugal. FAU - Silva, Marlene N AU - Silva MN AUID- ORCID: 0000-0003-4734-0283 AD - Research Center in Sports, Physical Education, Exercise and Health (CIDEFES), Universidade Lusofona, Campo Grande, 376, Lisboa 1749-024, Portugal. AD - CIFI2D, Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido Costa 91, Porto 4200-450, Portugal. LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - 301436/Z/23/Z/Wellcome Trust UK/ GR - 101095423/Horizon Europe/ PT - Journal Article PL - England TA - Health Promot Int JT - Health promotion international JID - 9008939 SB - IM MH - Humans MH - Adolescent MH - Nigeria MH - South Africa MH - Denmark MH - *Health Promotion/organization & administration/methods MH - Netherlands MH - Qualitative Research MH - Community-Based Participatory Research MH - Group Dynamics PMC - PMC13560076 OTO - NOTNLM OT - adolescents OT - co-creation OT - health inequities OT - movement behaviours OT - participatory research OT - physical activity OT - realist thinking COIS- The authors report there are no competing interests to declare. EDAT- 2026/09/10 11:53 MHDA- 2026/09/10 11:54 PMCR- 2026/09/10 CRDT- 2026/09/10 10:03 PHST- 2026/09/10 11:54 [medline] PHST- 2026/09/10 11:53 [pubmed] PHST- 2026/09/10 10:03 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - 8789919 [pii] AID - daag134 [pii] AID - 10.1093/heapro/daag134 [doi] PST - ppublish SO - Health Promot Int. 2026 Sep 1;41(5):daag134. doi: 10.1093/heapro/daag134. PMID- 42720098 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261015 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 9 IP - 9 DP - 2026 Sep 10 TI - Iodine supplementation for preventing iodine deficiency disorders in children and adolescents. PG - CD014475 LID - 10.1002/14651858.CD014475.pub2 [doi] LID - CD014475 AB - RATIONALE: Iodine is a micronutrient crucial in the early stages of human development, as it is essential for synthesising thyroid hormones involved in somatic growth and neurodevelopment. It is far better to prevent iodine deficiency than to treat it, since children are particularly vulnerable to iodine deficiency disorders, which involve a broad spectrum of consequences including endemic goitre, delayed growth and development of the central nervous system, intellectual impairment, and infant mortality. The primary dietary sources of iodine are iodised salt, seafood (animals and plants concentrate iodine from seawater), and grains from iodine-rich soils. Reliable evidence is needed on the benefits and harms of direct iodine supplementation in children and adolescents before considering its use to prevent the health consequences of iodine deficiency. OBJECTIVES: To assess the benefits and harms of iodine supplementation for preventing iodine deficiency in children and adolescents. SEARCH METHODS: We searched CENTRAL, MEDLINE, eight other databases, and two trials registries to 8 May 2025. We also searched the reference lists of retrieved studies. ELIGIBILITY CRITERIA: We included randomised controlled trials (RCTs) evaluating the benefits and harms of iodine supplementation alone (orally or by injection) or in combination with vitamins and minerals (orally or by injection) compared with placebo. OUTCOMES: Our critical outcomes were cognitive function assessed by validated scales, growth, hypothyroidism, and adverse events. Important outcomes included health-related quality of life, all-cause mortality, and goitre. RISK OF BIAS: We used the Cochrane RoB 2 tool to assess the risk of bias in the included studies. SYNTHESIS METHODS: Two review authors independently selected trials, extracted data, and assessed risk of bias. We used random-effects meta-analysis to combine data. We assessed the certainty of the evidence using GRADE. INCLUDED STUDIES: We included eight RCTs with a total of 2528 participants. The trials were conducted in seven countries between 1982 and 2009. The trials compared iodine supplementation (alone or with iron in one study) versus placebo. In one study, iodine supplementation was 150 mug daily for 28 weeks, while in the remaining studies, iodine supplementation was done in a single dose: 100 mg in a study on infants younger than 1 year, and a dose between 400 mg and 490 mg for children 6 to 17 years. Follow-up ranged from 3 to 22 months. SYNTHESIS OF RESULTS: Iodine supplementation versus placebo Iodine supplementation results in a slight increase in cognitive function compared to placebo (standardised mean difference 0.19, 95% confidence interval (CI) 0.04 to 0.34; 1 study, 166 participants; high-certainty evidence). Iodine supplementation may result in little to no difference in children's weight (kg) compared to placebo (mean difference (MD) -0.20, 95% CI -1.92 to 1.52; I(2) = 44%; 3 studies, 658 participants; low-certainty evidence). We downgraded the certainty of evidence by one level for imprecision and one level for heterogeneity. Iodine supplementation likely results in a large reduction in hypothyroidism compared to placebo (risk ratio (RR) 0.03, 95% CI 0.00 to 0.23; 1 study, 264 participants; moderate-certainty evidence). We downgraded the certainty of evidence by one level for risk of bias. No study reported adverse events related to iodine or quality of life. Iodine supplementation likely reduces all-cause mortality in infants compared to placebo (RR 0.32, 95% CI 0.14 to 0.73; 1 study, 617 participants; moderate-certainty evidence). We downgraded the certainty of evidence by one level for risk of bias. The evidence is very uncertain about the effect of iodine supplementation on the reduction of goitre (RR 0.68, 95% CI 0.15 to 3.07; I(2) = 97%; 2 studies, 432 participants; very low-certainty evidence). We downgraded the certainty of evidence by one level for imprecision, one level for heterogeneity, and one level for risk of bias. However, a sensitivity analysis removing the study with high risk of bias showed that iodine likely results in a large reduction in goitre (RR 0.31, 95% CI 0.22 to 0.45; 1 study, 230 participants; moderate-certainty evidence). Iodine plus iron supplementation versus placebo Iodine plus iron supplementation was compared to placebo in a single study. The evidence is very uncertain about the effect of iodine plus iron on weight (MD -0.40, 95% CI -1.44 to 0.64; 1 study, 146 participants; very low-certainty evidence). We downgraded the certainty of evidence by two levels for imprecision and one level for risk of bias. No other outcomes were assessed for this comparison. AUTHORS' CONCLUSIONS: Iodine supplementation, in the doses and follow-up periods evaluated in published RCTs, results in a slight increase in cognitive function and may result in little to no difference in growth. It likely reduces hypothyroidism and the risk of death in infants, but the evidence is very uncertain about its effect on the reduction of goitre. Future studies should focus on areas or populations in which iodine deficiency could be a problem, and include children of lower socioeconomic levels. They should evaluate higher doses of iodine administered during longer periods of treatment and follow-up times. FUNDING: This Cochrane review had no dedicated funding. REGISTRATION: Protocol (2023). DOI: 10.1002/14651858.CD014475. CI - Copyright (c) 2026 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. FAU - Velasco, Ines AU - Velasco I AUID- ORCID: 0000-0002-6143-6970 AD - Obstetrics and Gynecology, University Hospital Germans Trias i Pujol, Badalona, Spain. FAU - Rueda-Etxebarria, Mikel AU - Rueda-Etxebarria M AUID- ORCID: 0000-0002-4341-9245 AD - Free time independent Cochrane reviewer, Biobizkaia Health Research Institute, Cruces University Hospital, Bilbao, Spain. FAU - Trak-Fellermeier, Maria Angelica AU - Trak-Fellermeier MA AUID- ORCID: 0000-0003-2152-2935 AD - Department of Dietetics and Nutrition, Florida International University / Global Nutrition Professionals, Miami, Florida, USA. FAU - Taylor, Peter AU - Taylor P AUID- ORCID: 0000-0002-3436-422X AD - Thyroid Research Group, Division of Infection and Immunity, Cardiff University, Cardiff, UK. FAU - Rabassa Bonet, Montserrat AU - Rabassa Bonet M AUID- ORCID: 0000-0002-0276-6726 AD - Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. AD - Nutrition and Food Safety Research Institute (INSA-UB), Facultat de Farmacia i Ciencies de l'Alimentacio, Universitat de Barcelona, Barcelona, Spain. FAU - Chi, Yuan AU - Chi Y AUID- ORCID: 0009-0000-9745-2019 AD - Yealth Network, Beijing Yealth Technology Co., Ltd, Beijing, China. AD - Department of Health Research Methods, Evidence, & Impact, McMaster University, Hamilton, Canada. FAU - Janka, Heidrun AU - Janka H AUID- ORCID: 0000-0002-8677-4036 AD - Institute of General Practice, Medical Faculty of the Heinrich Heine University Dusseldorf, Dusseldorf, Germany. FAU - Rueda, Jose-Ramon AU - Rueda JR AUID- ORCID: 0000-0003-3560-7315 AD - Department of Preventive Medicine and Public Health, University of the Basque Country, Leioa, Spain. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260910 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 9679TC07X4 (Iodine) RN - 0 (Trace Elements) SB - IM UOF - doi: 10.1002/14651858.CD014475 MH - Adolescent MH - Child MH - Child, Preschool MH - Humans MH - Infant MH - Cognition/drug effects MH - Deficiency Diseases/prevention & control MH - *Dietary Supplements/adverse effects MH - Hypothyroidism/prevention & control MH - *Iodine/deficiency/administration & dosage/adverse effects MH - Quality of Life MH - Randomized Controlled Trials as Topic MH - *Trace Elements/administration & dosage PMC - PMC13559954 COIS- Ines Velasco (IV): none known. Mikel Rueda-Etxebarria (MRE): none known. Maria Angelica Trak-Fellermeier (MTF): none known. Peter Taylor (PT): none known. Montserrat Rabassa Bonet (MRB): none known. Yuan Chi (YC): none known. Heidrun Janka (HJ): none known. HJ is a member of the Cochrane Metabolic and Endocrine Disorders Group, but she was not involved in the editorial process of the review. Jose-Ramon Rueda (JRR): none known. EDAT- 2026/09/10 11:53 MHDA- 2026/09/10 11:54 PMCR- 2027/09/10 CRDT- 2026/09/10 09:02 PHST- 2026/09/10 11:54 [medline] PHST- 2026/09/10 11:53 [pubmed] PHST- 2026/09/10 09:02 [entrez] PHST- 2027/09/10 00:00 [pmc-release] AID - CD014475.pub2 [pii] AID - 10.1002/14651858.CD014475.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2026 Sep 10;9(9):CD014475. doi: 10.1002/14651858.CD014475.pub2. PMID- 42717780 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260917 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 5 DP - 2026 Sep TI - Intervention to Improve Running and Physical Activity Participation in Children With Generalised Joint Hypermobility: A Feasibility Study. PG - e70345 LID - 10.1111/cch.70345 [doi] LID - e70345 AB - BACKGROUND: Children with symptomatic paediatric generalised joint hypermobility (pgGJH) have limitations in physical activity and participation, yet there is a lack of research to guide intervention. In Australia, these children do not receive funding support. The objective of this study was to investigate the feasibility of a programme delivered in a private practice to improve running and associated goals of children with pgGJH from the perspectives of children, parents and staff. METHODS: Children with pgGJH undertook a weekly group running intervention and home exercise programme (HEP) for 10 weeks. Feasibility of delivery in a private paediatric therapy clinic was determined using physical and self-reported measures for acceptability, demand, implementation, practicality, integration and intervention efficacy. Semi-structured interviews with participants, therapists and managers explored multiple aspects of feasibility of the programme. RESULTS: Acceptability: satisfaction was rated between 6.5 and 9/10. Demand: 155 of 175 survey respondents were interested in the programme. Recruitment saw 24 participants invited, 10 excluded and 6 declined. Eight children aged 10-15 years (two female) participated and attended >/= 90% of sessions. The HEP was completed at least twice per week by 62% of participants. IMPLEMENTATION: the intervention was completed according to the protocol with one minor adverse event. Practicality: the intervention was well equipped but expensive to run with a therapist to participant ratio of 1:3. Integration: interventionists perceived the programme to fit well within the practice infrastructure and culture. EFFICACY: participants and parents reported improved running technique and increased confidence in physical activity. Leg stiffness improved and kinesiophobia was reduced. CONCLUSION: A running intervention for children with pgGJH was acceptable, in demand, practical to deliver and able to be integrated and implemented in a private clinic. Cost was the main challenge identified by families and management. CI - (c) 2026 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Chappell, Annie AU - Chappell A AUID- ORCID: 0000-0001-7092-8662 AD - School of Allied Health, Curtin University, Bentley, Western Australia, Australia. AD - Western Kids Health, Shenton Park, Western Australia, Australia. AD - School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Queensland, Australia. FAU - Jepson, Beverly AU - Jepson B AD - School of Allied Health, Curtin University, Bentley, Western Australia, Australia. AD - Western Kids Health, Shenton Park, Western Australia, Australia. FAU - Kilgour, Gaela AU - Kilgour G AUID- ORCID: 0000-0002-8867-7782 AD - Department of Physiotherapy, University of Melbourne, Parkville, Victoria, Australia. AD - Child Health Research Centre, University of Queensland, St Lucia, Queensland, Australia. LA - eng PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Child MH - Female MH - Feasibility Studies MH - Male MH - *Joint Instability/rehabilitation/physiopathology/psychology MH - *Running/physiology MH - Adolescent MH - *Exercise Therapy/methods MH - Patient Satisfaction MH - Australia PMC - PMC13559497 OTO - NOTNLM OT - feasibility OT - hypermobility OT - intervention OT - motor skill OT - physical activity OT - running COIS- Annie Chappell and Beverly Jepson were employees of Western Kids Health at the time of the study. Neither Curtin University nor Western Kids Health had any role in the planning or analysis of the study. EDAT- 2026/09/10 11:53 MHDA- 2026/09/10 11:54 PMCR- 2026/09/10 CRDT- 2026/09/10 05:16 PHST- 2026/08/20 00:00 [revised] PHST- 2026/04/24 00:00 [received] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/10 11:54 [medline] PHST- 2026/09/10 11:53 [pubmed] PHST- 2026/09/10 05:16 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - CCH70345 [pii] AID - 10.1111/cch.70345 [doi] PST - ppublish SO - Child Care Health Dev. 2026 Sep;52(5):e70345. doi: 10.1111/cch.70345. PMID- 42717667 OWN - NLM STAT- Publisher LR - 20260910 IS - 1613-6829 (Electronic) IS - 1613-6810 (Linking) DP - 2026 Sep 9 TI - Bioelectronic Wearable Sensors Produced by Computerized Embroidery Using a Dual Thread Approach. PG - e75624 LID - 10.1002/smll.75624 [doi] AB - Electronic textiles offer a promising route to wearable systems capable of continuous biophysical and biochemical monitoring. Their broader adoption remains limited by conductive threads that rarely support computerized embroidery (CEmb), reliable electronic integration, and reduced electrochemical capabilities due to coatings that degrade under bending, friction, or aqueous exposure. In this work, we use a dual-thread strategy that integrates silver-plated polyamide threads (AgPT) for high-conductivity pathways with PECOTEX, a chemically resilient PEDOT:PSS-coated cotton thread optimized for biochemical sensing. This approach preserves compatibility with CEmb, enhances electrochemical performance, and reduces cost by reserving AgPT for critical traces. We demonstrate a CEmb-compatible fabrication process for two wearable devices: a fully embroidered SmartBra for electrocardiography and a two-electrode ion sensor for potassium and sodium detection. We validate the design of our wearable dual-thread biosensors through laboratory characterization experiments and evaluate electrochemical sensing performance using a breast milk substitute, enabling realistic testing within women's health and infant-nutrition contexts. By focusing on scalable fabrication and meaningful applications, this work advances embroidered electronic textile systems toward practical, personalized healthcare monitoring. CI - (c) 2026 The Author(s). Small published by Wiley-VCH GmbH. FAU - Weinstein, Taliya AU - Weinstein T AUID- ORCID: 0000-0002-1443-2117 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Li, Xintong AU - Li X AUID- ORCID: 0009-0009-1941-1700 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Kurt, Hasan AU - Kurt H AUID- ORCID: 0000-0002-1677-644X AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Olenik, Selin AU - Olenik S AUID- ORCID: 0000-0002-8533-0169 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Collins, Alexander Silva-Pinto AU - Collins AS AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Flauzino, Jose Manuel Rodrigueiro AU - Flauzino JMR AUID- ORCID: 0000-0002-0437-4435 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Adeel, Muhammed AU - Adeel M AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Gonzalez-Macia, Laura AU - Gonzalez-Macia L AUID- ORCID: 0000-0003-1372-7965 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Yuce, Meral AU - Yuce M AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. AD - SUNUM Nanotechnology Research and Application Center, Sabanci University, Istanbul, Turkiye. FAU - Guder, Firat AU - Guder F AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. LA - eng GR - OPP1212574/Cytiva, Imperial College London, Department of Bioengineering, Gates Foundation/ GR - INV-038695/Cytiva, Imperial College London, Department of Bioengineering, Gates Foundation/ GR - W911QY-20-R-0022/US Army (U.S. Army Foreign Technology (and Science) Assessment Support program/ GR - 207687/Z/17/Z/WT_/Wellcome Trust/United Kingdom GR - 10004425/Innovate UK/ GR - 101111321/EU Horizon Europe Marie Sklodowska-Curie fellowship/ GR - 101025390/EU Horizon Europe Marie Sklodowska-Curie fellowship/ GR - EP/Y030273/1/UKRI MSCA fellowship/ GR - EP/G037515/1/EPSRC/ GR - EP/L016702/1/EPSRC/ PT - Journal Article DEP - 20260909 PL - Germany TA - Small JT - Small (Weinheim an der Bergstrasse, Germany) JID - 101235338 SB - IM OTO - NOTNLM OT - computerized embroidery OT - conductive cotton thread OT - electrochemical sensing OT - embroidered electronics OT - wearable electrocardiogram EDAT- 2026/09/10 11:53 MHDA- 2026/09/10 11:53 CRDT- 2026/09/10 05:09 PHST- 2026/08/04 00:00 [revised] PHST- 2026/03/30 00:00 [received] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/10 11:53 [medline] PHST- 2026/09/10 11:53 [pubmed] PHST- 2026/09/10 05:09 [entrez] AID - 10.1002/smll.75624 [doi] PST - aheadofprint SO - Small. 2026 Sep 9:e75624. doi: 10.1002/smll.75624. PMID- 42717507 OWN - NLM STAT- Publisher LR - 20260910 IS - 2737-5935 (Electronic) IS - 0037-5675 (Linking) DP - 2026 Sep 8 TI - Constructing personalised nutrition plans for adolescents using knowledge graphs and dietary profiles. LID - 10.4103/singaporemedj.SMJ-2026-038 [doi] AB - INTRODUCTION: Adolescence is a crucial period for youth development. However, many teenagers consume diets high in sugar and fat but low in essential nutrients, which can impair growth and increase the risk of obesity and metabolic diseases. This study developed a knowledge graph-based system that generates personalised menus for adolescents by combining structured nutrition data with individual dietary profiles, and evaluated its effects in a school setting. METHODS: An adolescent dietary knowledge graph was built to integrate 339 dishes, 246 ingredients, 30 nutrients and 26 adolescent nutrient problems. This framework was enriched with 300 individual dietary profiles capturing physiological traits, health risks and taste preferences. Furthermore, a rule-based engine generated daily menus, aiming to meet nutrient targets. This was assessed using diet-quality indicators and a three-month randomised controlled trial involving 400 adolescents (intervention: n = 200; control: n = 200). RESULTS: Recommended menus consistently showed higher scores on the Chinese Healthy Diet Index, Dietary Diversity Score and Food Variety Score than the non-intervention meals (P < 0.0001). Following the intervention, the personalised menu group demonstrated significantly lower increases in body weight, body mass index and body fat index compared to the control group (P < 0.05). Height gain did not differ significantly between groups (P = 0.088). CONCLUSION: These results suggest that knowledge graph-based personalised recommendation systems can translate established nutritional guidelines into structured, individualised dietary guidance for adolescents. This integrated approach provides a feasible digital framework for implementing guideline-concordant meal planning in school settings and may help bridge the gap between general recommendations and the diverse needs of growing teenagers. CI - Copyright (c) 2026 Singapore Medical Journal. FAU - Zhao, Fei AU - Zhao F AD - School of Public Health, Capital Medical University, Beijing, China. FAU - Ma, Weiwei AU - Ma W FAU - Xiao, Rong AU - Xiao R LA - eng PT - Journal Article DEP - 20260908 PL - India TA - Singapore Med J JT - Singapore medical journal JID - 0404516 SB - IM OTO - NOTNLM OT - Adolescents nutrition OT - dietary profiles OT - knowledge graph OT - randomised controlled trial OT - school-based intervention EDAT- 2026/09/10 05:36 MHDA- 2026/09/10 05:36 CRDT- 2026/09/10 05:00 PHST- 2026/01/15 00:00 [received] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/09/10 05:36 [medline] PHST- 2026/09/10 05:36 [pubmed] PHST- 2026/09/10 05:00 [entrez] AID - 00077293-990000000-00296 [pii] AID - 10.4103/singaporemedj.SMJ-2026-038 [doi] PST - aheadofprint SO - Singapore Med J. 2026 Sep 8. doi: 10.4103/singaporemedj.SMJ-2026-038. PMID- 42717323 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Aug 14 TI - Psychometric properties of the Turkish version of the Preschool Eating, Lifestyle, and Sleeping Attitudes (PRELSA) scale. LID - 10.1186/s12887-026-07532-9 [doi] LID - 847 AB - BACKGROUND: Childhood obesity in preschool years is strongly influenced by modifiable parental attitudes and behaviors. This study examined the validity and reliability of the Turkish version of the Preschool Eating, Lifestyle, and Sleeping Attitudes (PRELSA) Scale, which assesses parental attitudes related to childhood obesity during the preschool period. METHODS: This methodological study was conducted with 460 parents of children aged 2-6 years from seven preschools in Central Anatolia, Turkiye. Data were collected using a family and child information form and the PRELSA Scale. The adaptation process included forward-backward translation, expert review, face validity assessment, and psychometric evaluation. Data were analyzed using exploratory and confirmatory factor analyses, Cronbach's alpha, test-retest reliability, and intraclass correlation coefficients (ICC). RESULTS: The Turkish version comprised 39 items across 13 subscales. The overall Cronbach's alpha coefficient was 0.887. Exploratory factor analysis explained 58.5% of the total variance, with factor loadings ranging from 0.353 to 0.890. Confirmatory factor analysis indicated acceptable model fit (chi(2)/df = 1.434, RMSEA = 0.031, SRMR = 0.046, CFI = 0.904, IFI = 0.907, GFI = 0.911, TLI = 0.888). Test-retest reliability was high (r = 0.911), and the ICC was 0.865 (95% CI: 0.738-0.933), indicating good temporal stability. CONCLUSION: The Turkish PRELSA Scale is a valid and reliable instrument for assessing parental attitudes toward eating behaviors, physical activity, screen use, and sleep routines in early childhood. CI - (c) 2026. The Author(s). FAU - Bolacali, Edanur Tar AU - Bolacali ET AUID- ORCID: 0000-0001-8821-8554 AD - Faculty of Health Sciences, Department of Children Health and Disease Nursing, Kirsehir Ahi Evran University, Kirsehir, Turkiye. edanur.tar@ahievran.edu.tr. FAU - Bolacali, Memis AU - Bolacali M AUID- ORCID: 0000-0002-4196-2359 AD - Faculty of Medicine, Department of Biostatistics and Medical Informatics, Kirsehir Ahi Evran University, Kirsehir, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260814 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child, Preschool MH - Turkey MH - Male MH - Psychometrics MH - Female MH - Reproducibility of Results MH - Child MH - *Parents/psychology MH - *Life Style MH - *Sleep MH - Surveys and Questionnaires MH - *Pediatric Obesity/psychology/prevention & control MH - Factor Analysis, Statistical MH - *Feeding Behavior/psychology MH - *Attitude to Health PMC - PMC13560222 OTO - NOTNLM OT - Childhood obesity OT - Parents OT - Preschool child OT - Psychometrics OT - Validation study COIS- Declarations. Ethics approval and consent to participate: Written permission for the Turkish adaptation and use of the PRELSA Scale was obtained via email from corresponding author Carretero-Bravo on September 12, 2024. Before starting the study, ethical committee approval was obtained from the Scientific Research and Publication Ethics Committee of Kirsehir Ahi Evran University Faculty of Social and Human Sciences on February 26, 2025, with the number 2025/04/18. In addition, institutional permission for data collection was obtained from the Kirsehir Provincial Directorate of National Education on February 26, 2025, with the number MEB.TT.2025.019400. Prior to data collection, eligible parents were provided with detailed information about the study, and written informed consent was obtained from those who agreed to participate. They were also advised that participation was voluntary and that they could withdraw from the study at any time without consequence. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/10 05:36 MHDA- 2026/09/10 05:37 PMCR- 2026/08/14 CRDT- 2026/09/10 04:40 PHST- 2026/03/09 00:00 [received] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/10 05:37 [medline] PHST- 2026/09/10 05:36 [pubmed] PHST- 2026/09/10 04:40 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 10.1186/s12887-026-07532-9 [pii] AID - 7532 [pii] AID - 10.1186/s12887-026-07532-9 [doi] PST - epublish SO - BMC Pediatr. 2026 Aug 14;26(1):847. doi: 10.1186/s12887-026-07532-9. PMID- 42716963 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260921 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Sep 8 TI - Gender and socio-economic differences in physical activity and fitness among rural Bangladeshi adolescents: a cross-sectional study from the 15-year follow-up of MINIMat cohort. LID - 10.1038/s41598-026-70291-1 [doi] LID - 28206 AB - Given the paucity of objective physical activity (PA) and fitness assessment among adolescents in low-income settings, the underlying gender and socio-economic disparities remain poorly understood. Hence, we aimed to examine the associations of gender, household wealth and maternal education with PA and fitness among adolescents of a rural birth cohort in southeast Bangladesh. This cross-sectional study utilized data collected during the 15-year follow-up of MINIMat (Maternal and Infant Nutrition Interventions in Matlab) cohort. In total, (2)465 adolescents completed the household survey, and 2253 attended the subsequent PA and fitness assessment. Wrist-worn, triaxial accelerometers (dynamic range +/-8G) were used to estimate sedentary time (ST), and total and intensity-specific PA. Valid accelerometry data (>/= 5 days with >/= 600 min/day awake wear time) were available for 1872 adolescents. Fitness indicators assessed were: handgrip strength, standing long jump distance, and aerobic capacity (VO(2max)). We fitted multiple multivariable-adjusted linear regression models and derived predicted means. About 58% adolescents spent >/= 60 min/day in moderate-to-vigorous PA. After adjusting for socio-demographic variables, ST was higher among girls than boys (644 vs. 635 min/day; p < 0.001), in adolescents from the wealthiest than the poorest households (648 vs. 631 min/day; p < 0.001), and in adolescents with educated mothers compared to those having mothers without formal education (646 vs. 636 min/day; p = 0.005). While boys engaged in more vigorous PA (4 vs. 1 min(s)/day; p < 0.001), moderate PA was higher among girls (66 vs. 64 min/day; p = 0.007). Moderate-to-vigorous PA did not vary by gender, but was higher among socio-economically disadvantaged adolescents than their peers from wealthier households. Predicted levels of weight-normalized grip strength (0.66 vs. 0.51), standing long jump distance (160.2 vs. 126.3 cm), and VO(2max) (34.8 vs. 33.2 mL/kg/minute) were higher among boys than girls. Adolescents from the wealthiest households had lower muscular fitness than those from the poorest households. We observed gender and socio-economic differences in PA and fitness, with girls and adolescents from relatively affluent and educated households demonstrating lower activity and fitness levels. Context-specific strategies tailored to gender and socio-economic disparities are needed to promote PA and fitness among rural adolescents in Bangladesh. CI - (c) 2026. The Author(s). FAU - Islam, Mohammad Redwanul AU - Islam MR AUID- ORCID: 0000-0001-6005-0884 AD - Global Health and Migration Unit, Department of Women's and Children's Health, Uppsala University, Uppsala, 751 85, Sweden. mohammadredwanul.islam@uu.se. AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. mohammadredwanul.islam@uu.se. FAU - Delisle Nystrom, Christine AU - Delisle Nystrom C AUID- ORCID: 0000-0003-3496-8266 AD - Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. FAU - Krebs, Paula Zart AU - Krebs PZ AD - Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. FAU - Lof, Marie AU - Lof M AUID- ORCID: 0000-0002-2273-4430 AD - Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. FAU - Rahman, Syed Moshfiqur AU - Rahman SM AUID- ORCID: 0000-0002-9441-0590 AD - Global Health and Migration Unit, Department of Women's and Children's Health, Uppsala University, Uppsala, 751 85, Sweden. AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Ekstrom, Eva-Charlotte AU - Ekstrom EC AUID- ORCID: 0000-0001-5464-7756 AD - Global Health and Migration Unit, Department of Women's and Children's Health, Uppsala University, Uppsala, 751 85, Sweden. FAU - Rahman, Anisur AU - Rahman A AD - Global Health and Migration Unit, Department of Women's and Children's Health, Uppsala University, Uppsala, 751 85, Sweden. AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260908 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Adolescent MH - Bangladesh MH - Cross-Sectional Studies MH - Male MH - *Exercise/physiology MH - *Rural Population MH - *Physical Fitness/physiology MH - Follow-Up Studies MH - Socioeconomic Factors MH - Sex Factors MH - Socioeconomic Disparities in Health MH - Hand Strength MH - Accelerometry MH - Low Socioeconomic Status PMC - PMC13558767 OTO - NOTNLM OT - Accelerometry OT - Gender disparity OT - Grip strength OT - LMIC OT - Physical activity OT - Physical fitness OT - Rural adolescents OT - Sedentary time COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The present study was nested into the larger project of 15-year follow-up of the MINIMat (Maternal and Infant Nutrition Interventions in Matlab) trial, which has been approved by the Ethical Review Committee at icddr, b in Dhaka, Bangladesh (PR-17029; dated 23/05/2017). Written informed consent and assent were obtained from mothers and adolescents, respectively. Consent for publication: The study was conducted in strict accordance with the Declaration of Helsinki.All authors have read and approved the final manuscript and consented to its publication. EDAT- 2026/09/10 05:36 MHDA- 2026/09/10 05:37 PMCR- 2026/09/08 CRDT- 2026/09/10 00:13 PHST- 2026/03/07 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/09/10 05:37 [medline] PHST- 2026/09/10 05:36 [pubmed] PHST- 2026/09/10 00:13 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.1038/s41598-026-70291-1 [pii] AID - 70291 [pii] AID - 10.1038/s41598-026-70291-1 [doi] PST - epublish SO - Sci Rep. 2026 Sep 8;16(1):28206. doi: 10.1038/s41598-026-70291-1. PMID- 42716646 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1097-6752 (Electronic) IS - 0889-5406 (Linking) VI - 170 IP - 3 DP - 2026 Sep TI - Artificial intelligence-assisted analysis of tongue morphology and sagittal skeletal patterns: A multicenter study. PG - 415-424.e1 LID - S0889-5406(26)00189-7 [pii] LID - 10.1016/j.ajodo.2026.03.011 [doi] AB - INTRODUCTION: This study investigated the association between tongue morphology and sagittal skeletal patterns and assessed a deep learning model for automated tongue landmark detection and segmentation on lateral cephalometric radiographs (LCRs). METHODS: Pretreatment LCRs from 503 orthodontic patients (aged 6-40 years) were analyzed, categorized by dentition stage (mixed: 6-11; permanent: 12-40), and sagittal skeletal patterns. Tongue measurements were compared across subgroups. A multicenter dataset of 1179 LCRs trained a deep learning framework integrating U-Net for segmentation and RTMPose (real-time model for pose estimation) for landmark detection: tongue tip, dorsum of tongue, and base of the epiglottis. Model performance was assessed using mean radial error, success detection rate, mean intersection over union, and recall. External validation was performed on an independent hold-out dataset from 2 hospitals. RESULTS: In the permanent dentition group, subjects with Class Ⅲ malocclusion showed larger tongue areas than Class Ⅱ but not Class I; no significant differences in tongue area were observed in the mixed dentition group. The model achieved a mean radial error of 1.72 +/- 1.78 mm, success detection rates of 75.65% (/=1 trimester and a clinic BP reading 4 to 8 weeks postpartum were analyzed. Prepregnancy BMI was chart-abstracted; PA/sedentary behavior were measured each trimester via the activPAL3 micro. Hypertensive postpartum BP was defined as systolic BP >/=130 mm Hg or diastolic BP >/=80 mm Hg. Parallel-process latent growth modeling and K-means clustering identified PA trajectory groups; mediation analysis tested whether these groups explained the BMI-BP association. RESULTS: Among 388 participants (aged 30.9+/-4.5 years), 109 (28.4%) had hypertensive postpartum BP. Each 1-unit increase in prepregnancy BMI was associated with 6.0% greater risk of hypertensive postpartum BP (risk ratio, 1.06 [95% CI, 1.04-1.09]), adjusting for demographic and pregnancy characteristics. Three trajectory groups emerged: active-declining (n=142), active-improving (n=103), and consistently sedentary (n=143). The active-declining group had 37% lower risk than the consistently sedentary group, but this attenuated after BMI adjustment. Physical activity trajectories did not mediate the BMI-BP relationship, which was largely explained by prepregnancy BMI alone. CONCLUSIONS: Prepregnancy BMI predicted hypertensive postpartum BP independent of activity patterns, underscoring the clinical value of prepregnancy weight optimization and vigilant postpartum monitoring for those entering pregnancy with elevated BMI. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04749849. FAU - Borrowman, Jaclyn D AU - Borrowman JD AUID- ORCID: 0000-0003-3351-0173 AD - Feinberg School of Medicine Northwestern University Chicago IL USA. FAU - Crisp, Alex H AU - Crisp AH AD - Department of Health Sport, and Human Physiology, University of Iowa Iowa City IA USA. FAU - Jones, Melissa A AU - Jones MA AUID- ORCID: 0000-0002-7919-5247 AD - Department of Exercise Science Oakland University Rochester MI USA. FAU - Catov, Janet M AU - Catov JM AUID- ORCID: 0000-0002-9551-851X AD - Department of Obstetrics Gynecology, and Reproductive Science, University of Pittsburgh Pittsburgh PA USA. FAU - Gibbs, Bethany Barone AU - Gibbs BB AUID- ORCID: 0000-0002-0732-6148 AD - Department of Epidemiology and Biostatistics West Virginia University Morgantown WV USA. FAU - Whitaker, Kara M AU - Whitaker KM AUID- ORCID: 0000-0003-2343-4162 AD - Department of Health Sport, and Human Physiology, University of Iowa Iowa City IA USA. AD - Department of Epidemiology College of Public Health, University of Iowa Iowa City IA USA. LA - eng SI - ClinicalTrials.gov/NCT04749849 GR - R01 HL153095/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260909 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Body Mass Index MH - *Blood Pressure/physiology MH - Adult MH - *Postpartum Period/physiology MH - *Exercise/physiology MH - Young Adult MH - Sedentary Behavior MH - Adolescent MH - *Hypertension/physiopathology/epidemiology MH - Risk Factors OTO - NOTNLM OT - blood pressure OT - body mass index OT - physical activity OT - pregnancy EDAT- 2026/09/09 11:38 MHDA- 2026/09/16 05:36 CRDT- 2026/09/09 10:56 PHST- 2026/09/16 05:36 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 10:56 [entrez] AID - 10.1161/JAHA.126.051063 [doi] PST - ppublish SO - J Am Heart Assoc. 2026 Sep 15;15(18):e051063. doi: 10.1161/JAHA.126.051063. Epub 2026 Sep 9. PMID- 42713989 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260915 IS - 1940-087X (Electronic) IS - 1940-087X (Linking) IP - 235 DP - 2026 Sep 8 TI - Iron Deficiency Anemia in Pregnancy: Status and Contributing Factors Among Women in Northern Asir, Saudi Arabia. LID - 10.3791/72822 [doi] AB - Iron deficiency anemia (IDA) is a common nutritional disorder during pregnancy and is linked to adverse maternal and fetal outcomes. Beyond hematological markers, understanding related sociodemographic, dietary, and clinical factors is important for prevention. This study aimed to assess iron status and examine associations between sociodemographic characteristics, dietary habits, clinical factors, and IDA among pregnant women in Bisha, Saudi Arabia. A cross-sectional study was conducted from December 2022 to May 2023 at the Maternity and Children's Hospital in Bisha. The study included 135 pregnant women and 65 non-pregnant controls. Data was collected using a validated questionnaire covering demographics, diet, and clinical history. Blood samples were analyzed to measure hemoglobin, serum iron, ferritin, total and unsaturated iron-binding capacity, and transferrin saturation. Multivariate logistic regression identified independent risk factors for IDA. IDA was highly prevalent among pregnant women, particularly in the second trimester. Compared with controls, affected women had lower hemoglobin, serum iron, ferritin, and transferrin saturation, and higher iron-binding capacity. Lower intake of red meat, poultry, and citrus fruits, rural residence, and family history of anemia were independently associated with IDA. Fatigue and dizziness were more common among affected women. FAU - Belali, Tareg M AU - Belali TM AD - Faculty of Applied Medical Sciences, University of Bisha; blaly@ub.edu.sa. LA - eng PT - Journal Article PT - Video-Audio Media DEP - 20260908 PL - United States TA - J Vis Exp JT - Journal of visualized experiments : JoVE JID - 101313252 RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - Female MH - Saudi Arabia/epidemiology MH - Pregnancy MH - *Anemia, Iron-Deficiency/epidemiology/blood/etiology MH - Cross-Sectional Studies MH - *Pregnancy Complications, Hematologic/epidemiology/blood MH - Adult MH - Iron/blood MH - Young Adult EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 CRDT- 2026/09/09 08:22 PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 08:22 [entrez] AID - 10.3791/72822 [doi] PST - epublish SO - J Vis Exp. 2026 Sep 8;(235). doi: 10.3791/72822. PMID- 42713915 OWN - NLM STAT- Publisher LR - 20260909 IS - 2044-835X (Electronic) IS - 0261-510X (Linking) DP - 2026 Sep 9 TI - Framework for Rating and Assessing Media for Early childhood (FRAME): A multidimensional coding system for analysing children's media content. LID - 10.1111/bjdp.70066 [doi] AB - Young children spend an increasing amount of time engaging with screens, including television viewing. Although most research has focused on the quantity of children's viewing, growing evidence suggests that the developmental effects of screen media depend on the quality and characteristics of the content. However, there is currently no comprehensive, developmentally informed framework for systematically assessing the features of child-directed media. We developed the Framework for Rating and Assessing Media for Early childhood (FRAME), a multidimensional content analysis framework grounded in developmental literature that measures prosocial, antisocial and aggressive, educational, emotional, cultural, mental state talk and pacing content in children's television shows. The FRAME was applied to older (N = 22) and contemporary (N = 10) television shows watched by preschool-aged (2-5 years) children in Aotearoa New Zealand to characterize their content. Inter-rater reliability across dimensions and coding categories was acceptable to excellent. Convergent validity was demonstrated through correlations with Common Sense Media ratings, while also highlighting the value of a comprehensive and differentiated coding framework beyond existing measures. These findings demonstrate the reliability and validity of the FRAME and its potential to advance research examining how specific features of child-directed media relate to developmental outcomes. CI - (c) 2026 The Author(s). British Journal of Developmental Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society. FAU - Gath, Megan AU - Gath M AUID- ORCID: 0000-0002-8647-1262 AD - Child Well-being Research Institute, University of Canterbury, Christchurch, New Zealand. FAU - Swit, Cara AU - Swit C AUID- ORCID: 0000-0002-7198-5869 AD - School of Health Sciences, University of Canterbury, Christchurch, New Zealand. FAU - McLean, Mia AU - McLean M AUID- ORCID: 0000-0003-1186-3699 AD - Psychology & Neuroscience, Auckland University of Technology, Auckland, New Zealand. FAU - Wang, Ying AU - Wang Y AUID- ORCID: 0000-0003-0023-2023 AD - School of Social Sciences and Humanities, Auckland University of Technology, Auckland, New Zealand. FAU - Smith, Jen AU - Smith J AUID- ORCID: 0000-0003-4874-6808 AD - School of Leadership and Professional Practice, University of Canterbury, Christchurch, New Zealand. FAU - Turner, Damian AU - Turner D AUID- ORCID: 0009-0001-0323-9856 AD - Psychology & Neuroscience, Auckland University of Technology, Auckland, New Zealand. FAU - Gawn, Jenna AU - Gawn J AUID- ORCID: 0009-0006-4723-3794 AD - Child Well-being Research Institute, University of Canterbury, Christchurch, New Zealand. LA - eng PT - Journal Article DEP - 20260909 PL - England TA - Br J Dev Psychol JT - The British journal of developmental psychology JID - 8308022 SB - IM OTO - NOTNLM OT - coding system OT - content analysis OT - media OT - preschooler OT - screen time OT - television OT - young children EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:38 CRDT- 2026/09/09 08:19 PHST- 2025/10/09 00:00 [received] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 08:19 [entrez] AID - 10.1111/bjdp.70066 [doi] PST - aheadofprint SO - Br J Dev Psychol. 2026 Sep 9. doi: 10.1111/bjdp.70066. PMID- 42713456 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260910 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Syndrome differentiation and treatment of pediatric central precocious puberty: role of the spleen-kidney axis. PG - 1900121 LID - 10.3389/fimmu.2026.1900121 [doi] LID - 1900121 AB - Pediatric central precocious puberty (CPP) is driven by premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, along with immune-inflammatory imbalance, metabolic dysfunction, obesity, and gut microbiota-derived signals. According to traditional Chinese medicine (TCM) principles, kidney yin deficiency with hyperactive ministerial fire and spleen deficiency with phlegm-dampness form the basis for central pubertal activation and peripheral metabolic-inflammatory burden, thus supporting a combined approach for obesity-related or mixed-pattern CPP. Representative prescriptions include modified Zhibai Dihuang pills with Liujunzi decoction and modified Danzhi Xiaoyao powder with Erchen decoction, which integrate kidney yin-nourishment and ministerial fire-clearance with spleen qi-strengthening and phlegm resolution. Available clinical evidence suggests potential benefits in controlling secondary sexual characteristics, reducing gonadotropin and sex-steroid levels, and slowing bone-age advancement. Mechanistic studies indicate possible regulation of kisspeptin/GPR54/GnRH and LH/FSH-sex-steroid signaling, Th1/Th2/Treg homeostasis, NF-kappaB/NLRP3 pathways, adipokine imbalance, insulin resistance, hypothalamic inflammation, and gut microbiota-associated metabolism. However, most mechanistic links remain indirect, comparative trials are scarce, and direct correction of pathogenic MKRN3 or DLK1 variants has not been demonstrated. In this review, we have discussed the role of kidney and spleen dysfunction in CPP and explored the underlying mechanisms - particularly in the context of the neuro-endocrine-immune network that links central neuroendocrine activation with peripheral immune-metabolic signals. In addition, the application of TCM in the management of CPP, and the translational challenges of applying TCM as an adjunct to established CPP management have also been explored. Future research should prioritize CPP-specific pathway validation, identification of syndrome biomarkers, multi-omics-based stratification, multicenter trials, and long-term pediatric safety monitoring. CI - Copyright (c) 2026 Luo, Huang, Lu, He, Chen and Yang. FAU - Luo, Yujun AU - Luo Y AD - Pediatrics Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China. FAU - Huang, Chaojie AU - Huang C AD - The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. FAU - Lu, Yanting AU - Lu Y AD - The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. FAU - He, Jieying AU - He J AD - The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. FAU - Chen, Hailing AU - Chen H AD - The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. FAU - Yang, Jinghua AU - Yang J AD - Pediatrics Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China. LA - eng PT - Journal Article PT - Review DEP - 20260825 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Drugs, Chinese Herbal) SB - IM MH - Humans MH - *Puberty, Precocious/diagnosis/therapy/metabolism/etiology MH - *Spleen/metabolism/physiopathology MH - *Kidney/metabolism/physiopathology MH - Child MH - Hypothalamic-Pituitary-Gonadal Axis MH - Medicine, Chinese Traditional/methods MH - Animals MH - Drugs, Chinese Herbal/therapeutic use PMC - PMC13552407 OTO - NOTNLM OT - TCM syndrome differentiation OT - central precocious puberty OT - dual regulation of the kidney and spleen OT - hypothalamic-pituitary-gonadal axis OT - immune-inflammatory regulation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 07:49 PHST- 2026/06/04 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 07:49 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1900121 [doi] PST - epublish SO - Front Immunol. 2026 Aug 25;17:1900121. doi: 10.3389/fimmu.2026.1900121. eCollection 2026. PMID- 42713444 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260909 LR - 20261028 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - A case-control analysis: changes in gut microbiota composition in children with autism spectrum disorder. PG - 1890167 LID - 10.3389/fmicb.2026.1890167 [doi] LID - 1890167 AB - BACKGROUND: Gut microbiota dysbiosis has been increasingly implicated in autism spectrum disorder (ASD), with the gut-brain axis proposed as a potential mechanistic link. However, ASD-specific microbial signatures remain inconsistent across studies, and whether reported associations reflect primary dysbiosis or ASD-related confounders such as dietary restriction and gastrointestinal comorbidities remains debated. METHODS: A case-control study was conducted enrolling 54 children with ASD and 46 age- and sex-matched typically developing (TD) children. Full-length 16S rRNA gene sequencing was performed on the PacBio Sequel IIe third-generation platform using universal primers 27F/1492R, generating high-fidelity (HiFi) reads via on-instrument circular consensus sequencing (CCS). Gut microbiota differences were assessed using alpha- and beta-diversity analyses, phylum-level composition, Gut Microbiome Health Index (GMHI), Microbial Dysbiosis Index (MDI), differential abundance testing, and LEfSe analysis. RESULTS: No significant differences were observed in alpha-diversity between groups, whereas significant differences were identified in beta-diversity, GMHI, and MDI. Phylum-level analysis revealed a significantly reduced Bacillota/Bacteroidota ratio in the ASD group. More than 80% of ASD samples had negative GMHI values vs. more than 75% of TD samples with positive values, demonstrating superior discriminative performance compared with traditional diversity indices. Differential abundance analysis identified 15 differentially abundant species: 10 enriched in the TD group, predominantly butyrate-producing bacteria and Bifidobacterium spp., and 5 enriched in the ASD group, predominantly Bacteroides-affiliated taxa. LEfSe confirmed 16 differentially abundant taxa (LDA score >/= 3.0). CONCLUSION: Children with ASD exhibited significant differences in gut microbiota composition compared with TD children, characterized by a functional compositional imbalance-systematic depletion of butyrate-producing bacteria and Bifidobacterium spp. alongside enrichment of specific Bacteroides members-rather than alterations in overall species diversity. These findings are consistent with gut-brain axis dysregulation in ASD, though the cross-sectional design precludes causal inference and the possibility that observed differences reflect ASD-related dietary behavior cannot be excluded. GMHI demonstrated superior discriminative performance compared with traditional diversity indices in this cohort, though its application in pediatric ASD populations remains exploratory and requires independent validation in larger multicenter cohorts. CI - Copyright (c) 2026 Kang, Fan, Tian, Jin, Zhang, Sun and Liu. FAU - Kang, Le AU - Kang L AD - Department of Hand Surgery & Microsurgery and Foot & Ankle Surgery, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Fan, Linlin AU - Fan L AD - Department of Child Health Care, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Tian, Ying AU - Tian Y AD - Department of Neonatology, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Jin, Jiayi AU - Jin J AD - School of Pharmacy, Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Zhang, Na AU - Zhang N AD - Department of Gynecology, Jiaoqiao Central Health Center, Jiaoqiao, China. FAU - Sun, Caihong AU - Sun C AD - Department of Child Health Care, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Liu, Yang AU - Liu Y AD - School of Special Education and Rehabilitation, Shandong Medical and Pharmaceutical University, Yantai, China. LA - eng PT - Journal Article DEP - 20260825 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 EIN - Front Microbiol. 2026 Oct 13;17:2006584. doi: 10.3389/fmicb.2026.2006584. PMID: 42948388 PMC - PMC13552353 OTO - NOTNLM OT - 16S rRNA sequencing OT - autism spectrum disorder OT - case-control study OT - gut microbiota OT - microbial dysbiosis COIS- The author(s) declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 07:47 PHST- 2026/05/25 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 07:47 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1890167 [doi] PST - epublish SO - Front Microbiol. 2026 Aug 25;17:1890167. doi: 10.3389/fmicb.2026.1890167. eCollection 2026. PMID- 42713329 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260910 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Hypothalamic neuroimmune remodeling as an immunometabolic bridge between childhood obesity and earlier pubertal onset. PG - 1932785 LID - 10.3389/fimmu.2026.1932785 [doi] LID - 1932785 AB - While the link between childhood obesity and central precocious puberty (CPP) is well documented, the immune-mediated mechanisms that may precipitate earlier pubertal onset remain incompletely understood. This review proposes hypothalamic neuroimmune remodeling as a candidate immunometabolic bridge through which chronic low-grade peripheral inflammation may influence the timing of hypothalamic-pituitary-gonadal (HPG) axis activation. In obesity, systemic immune activation is primarily by adipose tissue macrophage infiltration, lipotoxic signaling, and gut dysbiosis. Peripheral inflammatory signals may reach the central nervous system through the arcuate nucleus-median eminence complex, disruption of the blood-brain barrier, and immune-mediated gut-brain pathways. Within the hypothalamus, these signals may elicit local neuroimmune responses. Glial cells, particularly microglia, astrocytes, and tanycytes, undergo inflammatory activation and release cytokines and lipid mediators, including IL-1beta, TNF-alpha, and prostaglandin E2. This localized neuroimmune response may alter the excitatory milieu and synaptic connectivity of the kisspeptin-GnRH network, thereby lowering the threshold for HPG axis activation. This review systematically synthesizes current evidence on this immune-endocrine crosstalk and describes how peripheral immune signals may remodel the hypothalamic microenvironment and alter pubertal timing. We further discuss the translational potential of targeting specific neuroimmune pathways for biomarker discovery and the development of novel immunomodulatory interventions for CPP. Although neuroimmune remodeling represents a plausible mechanism underlying obesity-associated pubertal advancement, its causal role requires further validation through targeted mechanistic studies and longitudinal immunophenotyping. CI - Copyright (c) 2026 Liu, Chen, Zhang, Peng, Lei and Liu. FAU - Liu, Ping AU - Liu P AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. AD - Hubei Shizhen Laboratory, Wuhan, Hubei, China. FAU - Chen, Yue AU - Chen Y AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. FAU - Zhang, Yujing AU - Zhang Y AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. AD - Hubei Shizhen Laboratory, Wuhan, Hubei, China. FAU - Peng, Yanhui AU - Peng Y AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. AD - Jianghan University Affiliated Hubei Third People's Hospital, Wuhan, Hubei, China. FAU - Lei, Enze AU - Lei E AD - Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China. FAU - Liu, Jianzhong AU - Liu J AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. AD - Hubei Shizhen Laboratory, Wuhan, Hubei, China. AD - Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China. LA - eng PT - Journal Article PT - Review DEP - 20260825 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Hypothalamus/immunology/metabolism MH - Hypothalamic-Pituitary-Gonadal Axis MH - Animals MH - *Pediatric Obesity/immunology/metabolism MH - *Neuroimmunomodulation MH - *Puberty, Precocious/immunology/metabolism MH - Child MH - Puberty/immunology PMC - PMC13551744 OTO - NOTNLM OT - HPG axis OT - central precocious puberty OT - childhood obesity OT - hypothalamic neuroimmune remodeling OT - kisspeptin-GnRH network OT - metaflammation OT - pubertal onset COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 07:34 PHST- 2026/07/09 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 07:34 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1932785 [doi] PST - epublish SO - Front Immunol. 2026 Aug 25;17:1932785. doi: 10.3389/fimmu.2026.1932785. eCollection 2026. PMID- 42713310 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1303-2968 (Electronic) IS - 1303-2968 (Linking) VI - 25 IP - 3 DP - 2026 Sep TI - Comparative Effects of Training Modalities on Countermovement Jump Performance in Soccer Players: A Systematic Review and Network Meta-Analysis. PG - 701-713 LID - 10.52082/jssm.2026.701 [doi] AB - The aim of this study was to provide a comprehensive comparison of training modalities for countermovement jump (CMJ) performance in soccer players using a network meta-analysis (NMA). PubMed, Web of Science, Embase, EBSCO, and the Cochrane Library were searched up to November 2025. Randomized controlled trials (RCTs) involving healthy soccer players, evaluating structured training interventions against comparator training or control conditions, and reporting CMJ height outcomes were included. A random-effects NMA was performed to estimate mean differences (MDs) with 95% confidence intervals (CIs), and interventions were ranked using P-scores, integrating both direct and indirect evidence. Subgroup analyses were conducted according to age, sex, and competitive level. Twenty-nine RCTs (n = 450) were included. The network showed moderate heterogeneity and no evidence of significant inconsistency. Combined training (CBT) was ranked highest in effect estimates in CMJ performance compared with traditional soccer training (TST) (MD = 4.92, 95% CI: 3.02-6.83, P-score = 0.98), followed by flywheel resistance training (FT) and plyometric training (PT), whereas other interventions did not demonstrate significant improvements. Subgroup analyses indicated that CBT ranked highest in males, youth, and Tier 2 players; PT ranked highest in females and adults; and FT ranked highest in highly trained players. Given the limited sample sizes, limited statistical power, and the fragmented nature of some subgroup comparisons, these findings should be interpreted cautiously. The network showed moderate heterogeneity (I(2) = 32.4%) and no evidence of significant inconsistency. The certainty of evidence was generally low to moderate according to the CINeMA assessment. Directness of evidence was generally high across comparisons, although several key contrasts (e.g., CBT vs FT and FT vs PT) relied partly on indirect evidence within the network. Although the highest-ranked interventions (CBT, FT, and PT) were supported primarily by direct comparisons with TST, several active-active contrasts relied partly on indirect estimates. The reliability of the intervention rankings depends on similarity in participant characteristics, intervention dose, outcome measurement, and control conditions. CI - (c) Journal of Sports Science and Medicine. FAU - Dong, Xusong AU - Dong X AD - School of Strength and Conditioning Training, Beijing Sport University, Beijing, China. FAU - Li, Tao AU - Li T AD - School of Chinese Basketball, Beijing Sport University, Beijing, China. FAU - Xing, Weihuan AU - Xing W AD - School of Strength and Conditioning Training, Beijing Sport University, Beijing, China. FAU - Chen, Zezhao AU - Chen Z AD - School of Strength and Conditioning Training, Beijing Sport University, Beijing, China. LA - eng PT - Comparative Study PT - Journal Article PT - Network Meta-Analysis PT - Systematic Review DEP - 20260901 PL - Turkey TA - J Sports Sci Med JT - Journal of sports science & medicine JID - 101174629 SB - IM MH - Humans MH - *Soccer/physiology MH - *Athletic Performance/physiology MH - *Plyometric Exercise MH - Resistance Training/methods MH - Randomized Controlled Trials as Topic MH - *Physical Conditioning, Human/methods PMC - PMC13552851 OTO - NOTNLM OT - Soccer OT - countermovement jump OT - explosive performance OT - network meta-analysis OT - training modalities EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/09/01 CRDT- 2026/09/09 07:32 PHST- 2026/04/24 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 07:32 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 10.52082/jssm.2026.701 [doi] PST - epublish SO - J Sports Sci Med. 2026 Sep 1;25(3):701-713. doi: 10.52082/jssm.2026.701. eCollection 2026 Sep. PMID- 42712825 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260909 LR - 20260910 IS - 0971-4502 (Print) IS - 0974-0449 (Electronic) IS - 0971-4502 (Linking) VI - 42 IP - 5 DP - 2026 Sep TI - Preharvest Platelet Counts Predict Response To Plerixafor in Pediatric Patients Undergoing Autologous Stem Cell Transplant. PG - 1653-1658 LID - 10.1007/s12288-025-02285-4 [doi] AB - Autologous stem cell transplantation (ASCT) following high dose chemotherapy is used for management of various pediatric malignancies, and plerixafor used in conjunction with GCSF is used to mobilize hematopoietic stem cells (HSCs) from bone marrow to peripheral blood for collection. While the efficacy and safety of plerixafor is established in adults, data for its use in children are limited. Factors influencing plerixafor response in pediatric patients have not been extensively investigated. This retrospective study aimed to identify predictors of response to plerixafor in pediatric patients undergoing ASCT. This single-center, retrospective study evaluated 22 pediatric patients who underwent mobilization with granulocyte colony-stimulating factor (GCSF) and plerixafor for ASCT between 2017 and 2024. Patient factors such as age, sex, baseline platelet count, marrow involvement, comorbidities, and malnutrition were recorded. Baseline platelet counts were measured on Day - 1 (the day prior to plerixafor administration). Treatment factors, including exposure to radiotherapy, anthracyclines, and multiple lines of chemotherapy, were also considered. CD34 + cell counts were measured before plerixafor administration and after harvest, and response was assessed by percentage, absolute, and log percent increase in CD34 counts. Regression analysis was done to look at the effect of various factors on response to plerixafor. The study found a significant increase in CD34 counts after plerixafor administration, with a median log percent increase of 3.54 (3.24-3.61). While age and malnutrition showed a significant correlation with log percent CD34 increase (p = 0.012 and p = 0.021, respectively), multivariate regression analysis revealed that only baseline platelet count achieved statistical significance as a predictor of response to plerixafor (p = 0.046). Pre-harvest baseline platelet count is an independent predictor of response to plerixafor in pediatric patients undergoing autologous stem cell transplantation. This finding suggests that baseline platelet counts can help predict the effectiveness of plerixafor-mediated stem cell mobilization in this patient population. Further larger prospective studies are warranted to validate these findings and identify additional factors influencing plerixafor response in pediatric patients. CI - (c) Indian Society of Hematology and Blood Transfusion 2025. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Batra, Satyendra AU - Batra S AD - Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110001 India. ROR: https://ror.org/02dwcqs71. GRID: grid.413618.9. ISNI: 0000 0004 1767 6103 FAU - Gupta, Aditya Kumar AU - Gupta AK AUID- ORCID: 0000-0002-3730-8944 AD - Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110001 India. ROR: https://ror.org/02dwcqs71. GRID: grid.413618.9. ISNI: 0000 0004 1767 6103 FAU - Meena, Jagdish Prasad AU - Meena JP AD - Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110001 India. ROR: https://ror.org/02dwcqs71. GRID: grid.413618.9. ISNI: 0000 0004 1767 6103 FAU - Seth, Rachna AU - Seth R AD - Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110001 India. ROR: https://ror.org/02dwcqs71. GRID: grid.413618.9. ISNI: 0000 0004 1767 6103 LA - eng PT - Journal Article DEP - 20251224 PL - India TA - Indian J Hematol Blood Transfus JT - Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion JID - 9425818 PMC - PMC13550363 OTO - NOTNLM OT - Autologous hematopoietic stem cell transplant OT - Mobilization OT - Pediatric OT - Plerixafor COIS- Conflict of interestNone to declare by any author. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2027/09/01 CRDT- 2026/09/09 06:43 PHST- 2025/08/15 00:00 [received] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 06:43 [entrez] PHST- 2027/09/01 00:00 [pmc-release] AID - 2285 [pii] AID - 10.1007/s12288-025-02285-4 [doi] PST - ppublish SO - Indian J Hematol Blood Transfus. 2026 Sep;42(5):1653-1658. doi: 10.1007/s12288-025-02285-4. Epub 2025 Dec 24. PMID- 42712511 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260909 LR - 20260910 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Developing a prediction model of neonatal pneumonia in patients with gestational diabetes mellitus in primary medical institutions. PG - 1840176 LID - 10.3389/fped.2026.1840176 [doi] LID - 1840176 AB - BACKGROUND: The incidence of gestational diabetes mellitus (GDM) continues to rise in China, and the risk of neonatal pneumonia is significantly increased, but the primary medical institutions lack simple and effective early risk assessment methods. OBJECTIVE: To construct a prediction model for neonatal pneumonia suitable for primary medical institutions, based on readily available clinical characteristics of pregnant women with GDM, we aimed to identify key risk factors and provide a basis for developing clinical intervention strategies. METHODS: Data on pregnant women and their newborns at Anyue Maternal and Child Health Hospital from 2023 to 2025 were retrospectively collected. Eight machine learning methods were used to construct the prediction model by bootstrap method and SHapley Additive exPlanations (SHAP) was used to enhance the model's interpretability. RESULTS: A total of 328 pairs of mothers and newborns were included, and the incidence of neonatal pneumonia was 8.8%. Among the eight prediction models, Random Forest model performed the best and Decision tree model was the worst; SHAP results indicated education level, BMI, hyperemesis gravidarum, primipara, hyperlipidemia during pregnancy, premature birth and job were most influencing factors. Binary logistic regression analysis showed that premature birth (OR = 4.763, 95% CI = 1.522-14.901, P = 0.007), Hyperemesis Gravidarum (OR = 3.706, 95% CI = 1.587-8.653, P = 0.002), and cesarean section (OR = 2.456, 95% CI = 1.050-5.745, P = 0.038) were risk factor of neonatal pneumonia, with a protective factor of higher education level (OR = 0.370, 95% CI = 0.158-0.865, P = 0.022). CONCLUSION: Despite the limited number of neonatal pneumonia events, our findings provide preliminary evidence that it may be feasible to develop a simplified risk-stratification tool for neonatal pneumonia in pregnancies complicated by GDM using routinely available clinical variables. Further multicentre prospective studies are required to determine the optimal predictor set and externally validate the model before clinical application. CI - (c) 2026 Wu, Cao, Wu, Liao, Li and Yang. FAU - Wu, Lian AU - Wu L AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Cao, Qun AU - Cao Q AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Wu, Jing AU - Wu J AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Liao, Ting AU - Liao T AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Li, Li AU - Li L AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Yang, Chengying AU - Yang C AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. LA - eng PT - Journal Article DEP - 20260825 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13550188 OTO - NOTNLM OT - gestational diabetes mellitus OT - hyperemesis during pregnancy OT - neonatal pneumonia OT - prediction model OT - preterm COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 06:08 PHST- 2026/03/27 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 06:08 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1840176 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 25;14:1840176. doi: 10.3389/fped.2026.1840176. eCollection 2026. PMID- 42712495 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260909 LR - 20260910 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Four laparoscopic surgical strategies for pediatric direct inguinal hernia: a retrospective single-center case series of six male children. PG - 1916132 LID - 10.3389/fped.2026.1916132 [doi] LID - 1916132 AB - OBJECTIVE: Pediatric direct inguinal hernia is a rare subtype of inguinal hernia, characterized by protrusion of abdominal viscera through the weak posterior wall of the inguinal canal without passing through the internal inguinal ring. This condition results from congenital hypoplasia of the transversalis fascia and focal structural defects in the inguinal region, with a lower incidence than pediatric indirect inguinal hernia. Multiple laparoscopic protocols for pediatric direct inguinal hernia have been reported, yet no unified surgical standard has been established, and relevant clinical data lack systematic collation. This retrospective single-center case series summarizes clinical experience of four laparoscopic repair techniques for pediatric direct inguinal hernia, with emphasis on surgical procedures, postoperative complications and long-term hernia recurrence. This study aims to report clinical outcomes of the four laparoscopic approaches and clarify the selection strategy of the four surgical modalities. METHODS: This is a retrospective, single-center, formal consecutive clinical case series. Inclusion criteria: 1) were intraoperatively confirmed as having primary direct inguinal hernia during laparoscopic surgery; 2) had complete electronic medical records, operative notes and outpatient follow-up data; 3) received laparoscopic repair techniques. Exclusion criteria: 1) combined indirect inguinal hernia, femoral hernia or other complicated inguinal region abnormalities; 2) recurrent hernia after prior inguinal surgery; 3) incomplete clinical or follow-up data. All patients underwent laparoscopic direct inguinal hernia repair at Shengli Oilfield Central Hospital between January 2019 and April 2026. Clinical data including age, gender, operation date, surgical technique and complications were retrospectively reviewed and analyzed. RESULTS: Six male pediatric patients met the inclusion criteria, and none satisfied any exclusion criterion. Among them, five presented with unilateral hernia and one with bilateral hernia. The median age was 3 years and 9 months (range: 2 years and 1 month to 7 years and 3 months). All children were preoperatively suspected to have indirect inguinal hernia by physical examination, while direct inguinal hernia was confirmed intraoperatively. All patients received laparoscopic repair adopting four distinct surgical techniques: laparoscopic eversion and lateral fixation of direct hernia sac, laparoscopic high ligation of direct hernia sac, laparoscopic reinforcement with medial umbilical ligament, and combined laparoscopic high ligation of hernia sac plus medial umbilical ligament reinforcement. All operations were completed successfully with minimal intraoperative blood loss. No intraoperative injuries to the vas deferens, spermatic vessels, testis, bowel, urinary bladder, external iliac vessels or nerves were identified. Oral liquid diet was resumed 6 to 8 h after surgery, and daily activities were restored within 24 h postoperatively. No short-term complications such as surgical site infection or hematoma occurred in any patient. The final follow-up was conducted in June 2026 before manuscript submission, with follow-up durations ranging from 5 months to 82 months. No long-term complications including hernia recurrence, testicular atrophy or chronic inguinal pain were documented in all subjects. CONCLUSION: Laparoscopic surgery is safe, reliable and minimally invasive for pediatric direct inguinal hernia. Based on our single-center experience, surgical selection depends on whether the hernia sac is amenable to ligation and whether the medial umbilical ligament can sufficiently cover the Hesselbach's triangle. Large-cohort studies are required to further validate the clinical efficacy of each repair strategy. CI - (c) 2026 Xu, Han, Ding, Zhang, Liu, Jiang and Shi. FAU - Xu, Yan AU - Xu Y AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. FAU - Han, Shuaishuai AU - Han S AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. FAU - Ding, Haixin AU - Ding H AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. FAU - Zhang, Fenghui AU - Zhang F AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. FAU - Liu, Siyu AU - Liu S AD - Department of Medical Records Management, Shengli Oilfield Central Hospital, Dongying, China. FAU - Jiang, Wenxin AU - Jiang W AD - Department of Pediatrics, Shengli Oilfield Central Hospital, Dongying, China. FAU - Shi, Jizhou AU - Shi J AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. AD - Department of Pediatric Surgery, Dongying District People's Hospital, Dongying, China. LA - eng PT - Journal Article DEP - 20260825 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13550138 OTO - NOTNLM OT - case series OT - hernia sac eversion OT - hernia sac ligation OT - hesselbach's triangle OT - laparoscopic hernia repair OT - pediatric direct inguinal hernia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 06:04 PHST- 2026/06/22 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 06:04 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1916132 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 25;14:1916132. doi: 10.3389/fped.2026.1916132. eCollection 2026. PMID- 42712217 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260914 IS - 1471-2865 (Electronic) IS - 1358-2267 (Print) IS - 1358-2267 (Linking) VI - 31 IP - 4 DP - 2026 Oct TI - Criterion Validity of the 30-Second Chair Stand Test for Lower-Limb Muscle Strength in Adults With Severe Mental Disorders: The PsychiActive Project. PG - e70344 LID - 10.1002/pri.70344 [doi] LID - e70344 AB - BACKGROUND AND PURPOSE: Individuals with Severe Mental Disorders (SMDs) face a high risk of premature mortality and disability due to accelerated neuromuscular decline. Despite the critical need to monitor physical function, the lack of validated, time-efficient tools limits their clinical utility and hinders the integration of objective assessments into routine care. This gap limits the early identification of physical function impairments and the implementation of timely evidence-based interventions. This is the first study to evaluate the criterion validity of the 30-s Chair Stand Test (30s-CST) as a pragmatic indicator of lower-limb muscle strength in adults with SMDs, providing a feasible functional indicator to support routine clinical assessment. METHODS: Using a cross-sectional validation design (STROBE), this study was conducted with 91 adults (18-65 years) diagnosed with SMDs. Participants performed the 30s-CST and reference isometric Knee Extension Strength (KES) testing. Statistical analyses included Pearson's correlation (r), Intraclass Correlation Coefficients (ICC), and Bland-Altman plots to determine agreement and heteroscedasticity, with sub-analyses by sex, age, and body mass index. RESULTS: Analysis revealed significant moderate correlation and agreement (r = 0.56 [95% CI 0.40-0.69]; ICC = 0.54 [0.38-0.67]; both p < 0.001) for the total sample, with stronger results in the female subgroup. The 30s-CST demonstrated precision, with a prediction error lower than the within-subject variability of the reference method. Bland-Altman plots showed acceptable agreement, with narrow limits of agreement (-1.79-1.80), and analysis indicated homoscedasticity. DISCUSSION: The 30s-CST appears to be a pragmatic and time-efficient screening tool for identifying individuals with reduced lower-limb muscle strength in SMDs. Although limited by the lack of biomechanical specificity between dynamic and isometric methods, the test offers a balance between clinical feasibility and its ability to provide a functional estimate related to lower-limb muscle strength. Integrating this pragmatic screening tool into routine practice may support the assessment of functional performance in resource-constrained settings where more complex strength assessments are not readily available. CI - (c) 2026 The Author(s). Physiotherapy Research International published by John Wiley & Sons Ltd. FAU - Lopez-Moral, Alvaro AU - Lopez-Moral A AUID- ORCID: 0000-0003-0862-8655 AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Seville, Spain. AD - Department of Physical Education and Sport, Universidad de Sevilla, Seville, Spain. FAU - Munguia-Izquierdo, Diego AU - Munguia-Izquierdo D AUID- ORCID: 0000-0001-7817-747X AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Seville, Spain. AD - Research Group in Development Movimiento Humano, Universidad de Zaragoza, Zaragoza, Spain. FAU - Bueno-Antequera, Javier AU - Bueno-Antequera J AUID- ORCID: 0000-0001-8063-3980 AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Seville, Spain. AD - Research Group in Development Movimiento Humano, Universidad de Zaragoza, Zaragoza, Spain. LA - eng GR - PID2020-118262RB-I00/Ministerio de Ciencia e Innovacion/ GR - POSTDOC_21_00059/Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades/ GR - PPI1803/Universidad Pablo de Olavide/ PT - Journal Article PT - Validation Study PL - United States TA - Physiother Res Int JT - Physiotherapy research international : the journal for researchers and clinicians in physical therapy JID - 9612022 SB - IM MH - Humans MH - Female MH - *Muscle Strength/physiology MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - Male MH - Reproducibility of Results MH - *Lower Extremity/physiopathology MH - *Mental Disorders/physiopathology MH - Aged MH - Young Adult MH - Adolescent PMC - PMC13555177 OTO - NOTNLM OT - chair stand test OT - functional assessment OT - muscle strength OT - physical function OT - physical performance OT - rehabilitation OT - severe mental disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/09/09 CRDT- 2026/09/09 05:32 PHST- 2026/08/05 00:00 [revised] PHST- 2026/03/04 00:00 [received] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 05:32 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - PRI70344 [pii] AID - 10.1002/pri.70344 [doi] PST - ppublish SO - Physiother Res Int. 2026 Oct;31(4):e70344. doi: 10.1002/pri.70344. PMID- 42711707 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 Aug 27 TI - Conflicting evidence for continuous glucose monitoring in gestational diabetes: current challenges and the imperative for individual participant data meta-analysis. LID - 10.1186/s12916-026-05191-2 [doi] LID - 476 AB - BACKGROUND: The incidence of gestational diabetes mellitus (GDM) is rising along with rates of obesity and type 2 diabetes. GDM is associated with an increased risk of various short- and long-term complications for both mother and child, including type 2 diabetes. Managing GDM requires a multidisciplinary approach that includes dietary guidance, promoting regular physical activity, and performing self-monitoring of blood glucose (SMBG). Continuous glucose monitoring (CGM) has transformed pregnancy care in women with type 1 diabetes and is increasingly being proposed as a strategy to improve glycaemic management in GDM. By capturing postprandial glucose excursions, glycaemic variability, and time in range, CGM provides a more detailed picture of glycaemia and has raised expectations of improved metabolic control and pregnancy outcomes. MAIN BODY: Despite these theoretical advantages, evidence for CGM in GDM remains conflicting. More recently, several large randomized controlled trials (RCT's) show conflicting data: some studies show modest improvements in glycaemic measures, whereas others report no clear benefit for key maternal or neonatal outcomes, leaving the clinical value and cost-effectiveness of CGM unclear. A major limitation is the absence of validated CGM-based glycaemic targets specific to GDM, and current guidelines offer little direction beyond conventional SMBG guidelines. Future research should prioritize adequately powered large RCT's representing a broad population, and, importantly, individual participant data meta-analyses to reconcile inconsistent findings, identify subgroups most likely to benefit, establish pregnancy-specific CGM thresholds, and evaluate the impact on both obstetric outcomes and long-term postpartum metabolic risk. CONCLUSIONS: This ongoing debate underscores the need to critically appraise the role of CGM in GDM, summarize results from completed RCT's and meta-analyses, recognize key methodological and clinical evidence gaps, and outline the steps required for CGM to become fully integrated into standard GDM care. CI - (c) 2026. The Author(s). FAU - Geerts, Ina AU - Geerts I AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. FAU - Yu, Catherine AU - Yu C AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. FAU - Embo, Nina AU - Embo N AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. FAU - Benhalima, Katrien AU - Benhalima K AUID- ORCID: 0000-0002-3325-0263 AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. katrien.benhalima@uzleuven.be. AD - Department of Endocrinology, University Hospitals Leuven, 3000, Leuven, Belgium. katrien.benhalima@uzleuven.be. LA - eng PT - Journal Article PT - Review DEP - 20260827 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 RN - 0 (Blood Glucose) SB - IM MH - Female MH - Humans MH - Pregnancy MH - *Blood Glucose/analysis MH - *Blood Glucose Self-Monitoring/methods MH - *Continuous Glucose Monitoring MH - *Diabetes, Gestational/blood/diagnosis/therapy MH - Meta-Analysis as Topic PMC - PMC13556021 OTO - NOTNLM OT - Continuous glucose monitoring OT - Gestational diabetes mellitus OT - Individual participant data meta-analysis OT - Pregnancy OT - Technology COIS- Declarations. Ethics approval and consent to participate: not applicable. Consent for publication: not applicable. AI statement: Microsoft Copilot was used solely for language editing to improve the clarity and readability of the manuscript. The authors reviewed and edited all AI-assisted text and take full responsibility for the content of the manuscript. Competing interests: I.G. is the recipient of a PhD fellowship, strategic basic research (FWO-SB) from the Flemish Research Council (FWO) 1S82826N. KB received a senior clinical fellowship from FWO Flanders (1800220 N). KB received an unrestricted grant and study devices from Medtronic for the investigator-initiated CRISTAL study. KB received study devices from Dexcom for the investigator-initiated GLORIA study. KB received study medication from Novo Nordisk A/S for the investigator-initiated SERENA study. KB received study devices from Abbott and LifeScan, and a grant from Abbott for the investigator-initiated CORDELIA study. KB received a speaker's fee from Novo Nordisk, AstraZeneca, and Medtronic. KB was a Guest Editor for the Diagnosis and Management of Gestational Diabetes collection (special issue on gestational diabetes). All other authors declared no competing interests. EDAT- 2026/09/09 07:07 MHDA- 2026/09/09 11:38 PMCR- 2026/08/27 CRDT- 2026/09/09 04:50 PHST- 2026/05/26 00:00 [received] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/09/09 07:07 [pubmed] PHST- 2026/09/09 04:50 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.1186/s12916-026-05191-2 [pii] AID - 5191 [pii] AID - 10.1186/s12916-026-05191-2 [doi] PST - epublish SO - BMC Med. 2026 Aug 27;24(1):476. doi: 10.1186/s12916-026-05191-2. PMID- 42711563 OWN - NLM STAT- Publisher LR - 20260909 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Sep 8 TI - Comparing two diagnostic frameworks for obesity in Mexican children attending a pediatric obesity clinic. LID - 10.1038/s41390-026-05479-2 [doi] AB - BACKGROUND: Body mass index (BMI) is widely used to assess pediatric obesity but does not fully capture adiposity-related organ dysfunction. The Clinical Framework of Obesity 2025 (CFO-2025), proposed by The Lancet Diabetes & Endocrinology Commission, offers a complementary clinical approach. OBJECTIVE: To evaluate pediatric obesity classification using Centers for Disease Control and Prevention BMI (CDC-BMI) criteria and the CFO-2025, and to describe organ-system involvement in clinical obesity. METHODS: This cross-sectional study analyzed 220 patients aged 4-16 years from a pediatric obesity clinic in northeastern Mexico. Obesity was classified using CDC-BMI criteria and the CFO-2025 with pediatric adaptations. Under the CFO-2025, patients were categorized as having preclinical or clinical obesity based on organ-system involvement. Concordance was assessed using Cohen's kappa. RESULTS: Obesity prevalence was 80% by CDC-BMI criteria and 95% by the CFO-2025, with fair concordance (kappa = 0.321; p < 0.001). Clinical obesity was identified in 83.2% of patients, including those classified as having normal weight or overweight by CDC-BMI; metabolic (73.2%) and cardiovascular (59%) systems were most frequently affected. CONCLUSIONS: Applied alongside BMI, the CFO-2025 identified additional multisystem involvement. Although not yet validated in children, it may support a more comprehensive clinical assessment of pediatric obesity. IMPACT: In the Pediatric Obesity Clinic at a referral hospital in northeastern Mexico, the Clinical Framework of Obesity 2025 (CFO-2025) classified a higher proportion of children as having obesity compared with the CDC-BMI criteria, with only fair concordance between systems. We provide preliminary pediatric evidence that the CFO-2025 identifies multisystem involvement, including metabolic and cardiovascular abnormalities, even among children categorized as normal weight or overweight by BMI. Although the CFO-2025 has not yet been validated in pediatric populations, integrating BMI with the CFO-2025 may support a more structured and comprehensive assessment of obesity-related organ involvement in children. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Guzman-Garcia, Judith E AU - Guzman-Garcia JE AD - Pediatric Obesity Clinic, Hospital Regional Materno Infantil, Guadalupe, Mexico. drajudithguzman@gmail.com. AD - Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico. drajudithguzman@gmail.com. FAU - Gomez-Orozco, Patricio AU - Gomez-Orozco P AD - Pediatric Obesity Clinic, Hospital Regional Materno Infantil, Guadalupe, Mexico. AD - Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Mexico. FAU - Velasco-Rodriguez, Victor Manuel AU - Velasco-Rodriguez VM AD - Universidad Autonoma de Coahuila, Faculty of Nursing, Laguna Unit, Torreon, Mexico. FAU - Martinez-Tapia, Maria Elena AU - Martinez-Tapia ME AD - Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico. FAU - Rodriguez-Gutierrez, Nora A AU - Rodriguez-Gutierrez NA AUID- ORCID: 0009-0003-0302-7145 AD - Pediatric Obesity Clinic, Hospital Regional Materno Infantil, Guadalupe, Mexico. AD - Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico. LA - eng PT - Journal Article DEP - 20260908 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: The requirement for individual informed consent was waived by the Ethics Committee of the Hospital Regional Materno Infantil and the Department of Education, Health Research, and Quality of the Ministry of Health of Nuevo Leon due to the retrospective design of the study and the use of de-identified data. EDAT- 2026/09/09 07:07 MHDA- 2026/09/09 07:07 CRDT- 2026/09/09 04:27 PHST- 2026/02/24 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/06/26 00:00 [revised] PHST- 2026/09/09 07:07 [medline] PHST- 2026/09/09 07:07 [pubmed] PHST- 2026/09/09 04:27 [entrez] AID - 10.1038/s41390-026-05479-2 [pii] AID - 10.1038/s41390-026-05479-2 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Sep 8. doi: 10.1038/s41390-026-05479-2. PMID- 42711085 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260912 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 8 TI - School- and home-based hybrid exercise intervention to prevent summer fitness loss in children: protocol for a feasibility study of the keep moving in a structured summer programme. PG - e123307 LID - 10.1136/bmjopen-2026-123307 [doi] LID - e123307 AB - INTRODUCTION: Schools are key settings to intervene for the purpose of health promotion in children. However, the effectiveness of school-based interventions remains limited, potentially related to the obesogenic behaviours observed during holidays as posited by the structured days hypothesis. This study aims to evaluate the feasibility, process evaluation and preliminary efficacy of the keep moving in a structured summer (KEMOSS) intervention among Chinese children. METHODS AND ANALYSIS: The KEMOSS intervention is an 8-week hybrid programme comprising two digitally supported home-based phases (weeks 1-2 and 7-8) and a structured school-based phase (weeks 3-6). The school-based phase will be a full-day scheduled programme that replicates the routine of regular school days, with a coach-led structured physical activity lesson and a free-play lesson embedded in the morning and afternoon, respectively. During the home-based phases, participants will be encouraged to complete prescribed exercises independently with support from mHealth reminders and instructional materials and to achieve a minimum of 10 000 steps per day. Feasibility, process evaluation and preliminary efficacy outcomes will be assessed using a mixed-methods approach. Quantitative data will be analysed using SPSS, while qualitative data from interviews and focus groups will be analysed thematically using NVivo. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Ningbo University Ethics Committee (TY2026028). Findings will inform the refinement of the intervention and the design of a future definitive trial. Results will be disseminated through peer-reviewed publications and conference presentations. TRIAL REGISTRATION NUMBER: ChiCTR2600126738. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Liu, Yong AU - Liu Y AUID- ORCID: 0009-0008-3649-5064 AD - Department of Sports and Arts, Zhejiang Wanli University, Ningbo, Zhejiang, China. FAU - Gu, Jiayi AU - Gu J AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Li, Minghui AU - Li M AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Guo, Qiang AU - Guo Q AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Geng, Renshang AU - Geng R AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Dai, Lulin AU - Dai L AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Xiao, Peizhen AU - Xiao P AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Zheng, Yuanyuan AU - Zheng Y AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Sun, Fucheng AU - Sun F AUID- ORCID: 0009-0003-5539-721X AD - Department of Physical Education, Nanjing Agricultural University, Nanjing, Jiangsu, China fucheng.sun@hotmail.com. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260908 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Feasibility Studies MH - Seasons MH - Clinical Trials as Topic MH - *Physical Fitness MH - *Program Evaluation MH - *School Health Services MH - Humans MH - Child MH - *Exercise Therapy/methods MH - Research Design MH - Play and Playthings MH - *Telemedicine MH - Exercise MH - China PMC - PMC13560971 OTO - NOTNLM OT - Child OT - Feasibility Studies OT - Physical Fitness OT - Randomized Controlled Trial OT - Schools COIS- Competing interests: None declared. EDAT- 2026/09/08 23:35 MHDA- 2026/09/08 23:36 PMCR- 2026/09/08 CRDT- 2026/09/08 21:03 PHST- 2026/09/08 23:36 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 21:03 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - bmjopen-2026-123307 [pii] AID - 10.1136/bmjopen-2026-123307 [doi] PST - epublish SO - BMJ Open. 2026 Sep 8;16(9):e123307. doi: 10.1136/bmjopen-2026-123307. PMID- 42711081 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260912 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 8 TI - AllPlay Dance autism: protocol for a randomised controlled trial of a community-based dance programme for children with autism. PG - e122285 LID - 10.1136/bmjopen-2026-122285 [doi] LID - e122285 AB - INTRODUCTION: Motor skills are integral to numerous developmental domains throughout infancy and childhood. In autism, motor impairments are prevalent and pervasive, often appearing before core symptoms. These motor difficulties have a cascading effect on a child's broader physical and psychological health, including social, cognitive, emotional and behavioural functioning. Accordingly, researchers are increasingly interested in interventions that improve motor functioning, as these may have a downstream effect on broader developmental domains. One intervention that could address motor difficulties is the AllPlay Dance programme, which provides inclusive dance classes to children in community settings, with pilot data demonstrating acceptability and feasibility among parents and their children with autism and cerebral palsy. This pragmatic randomised controlled trial (pRCT) is thus designed to evaluate whether the AllPlay Dance programme creates the conditions for motor, cognitive and social abilities to thrive in children with autism. METHOD AND ANALYSIS: This pRCT intends to enrol 70 families of children with autism, aged 7-12 years, living in Victoria, Australia. We will also enrol up to 60 participants with previous dance experience, called buddies, to support the participation of our dancers with autism. We will use our clinical, research, university and community networks to recruit participants. Interested families will complete an online screening survey, followed by questionnaires that parents complete and assessments of the motor functioning in the children. Interested buddies will also complete an online screening survey followed by a baseline questionnaire. Families will be randomly allocated to the intervention group or the treatment-as-usual waitlist control group. The intervention group will attend 9 weeks of community-based dance classes led by disability and dance experts and supported by buddies. The primary outcome is change in motor functioning, as assessed through performance-based measures, with parent reports providing complementary information about everyday motor functioning. Secondary outcomes include improvements in the executive, social, emotional and behavioural functioning of the children, as well as decreases in the stress of parents. We will also evaluate the acceptability and feasibility of this programme, as well as whether families decide to enrol and engage with other dance programmes in the community following the intervention. ETHICS AND DISSEMINATION: The study has received approval from the Monash University Human Research Ethics Committee and the Deakin University Human Research Ethics Committee. Findings will be disseminated through a PhD thesis, peer-reviewed publications, presentations at scientific conferences and reports to participants, community organisations and the wider community. TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trials Registry (ANZCTR); ACTRN12625000600448; registered on 11 June 2025; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=389672. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Chadha, Mehak AU - Chadha M AUID- ORCID: 0009-0005-3306-3491 AD - Monash University, Melbourne, Victoria, Australia mehak.chadha@monash.edu. FAU - Lindor, Ebony AU - Lindor E AD - Monash University, Melbourne, Victoria, Australia. FAU - Millard, Olivia AU - Millard O AD - Deakin University, Melbourne, Victoria, Australia. FAU - Moss, Simon AU - Moss S AD - Monash University, Melbourne, Victoria, Australia. FAU - Rinehart, Nicole AU - Rinehart N AD - Monash University, Melbourne, Victoria, Australia. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260908 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Child MH - *Autistic Disorder/therapy/rehabilitation MH - *Dance Therapy/methods MH - *Dancing MH - Randomized Controlled Trials as Topic MH - Male MH - Female MH - Victoria MH - Motor Skills PMC - PMC13561022 OTO - NOTNLM OT - Autistic Disorder OT - Dancing OT - Exercise OT - MENTAL HEALTH OT - Motor Skills OT - Pragmatic Clinical Trial COIS- Competing interests: None declared. EDAT- 2026/09/08 23:35 MHDA- 2026/09/08 23:36 PMCR- 2026/09/08 CRDT- 2026/09/08 21:03 PHST- 2026/09/08 23:36 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 21:03 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - bmjopen-2026-122285 [pii] AID - 10.1136/bmjopen-2026-122285 [doi] PST - epublish SO - BMJ Open. 2026 Sep 8;16(9):e122285. doi: 10.1136/bmjopen-2026-122285. PMID- 42710441 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261013 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 203 DP - 2026 Dec TI - The interplay between interoceptive sensibility and mindfulness in eating behaviors and psychological distress: A person-centered study in a French community sample. PG - 51-59 LID - S0022-3956(26)00427-9 [pii] LID - 10.1016/j.jpsychires.2026.09.001 [doi] AB - This study examined interoception and mindfulness as related processes in eating behaviors in a non-clinical population. The aim was to identify interoceptive sensibility and mindfulness clusters using a person-centered approach and to examine their associations with eating behaviors, eating disorder risk, body mass index, and psychological distress. An online survey was conducted in a French community sample of 381 adults. Participants completed validated self-report measures assessing interoceptive sensibility, mindfulness, eating behaviors, and psychological distress. Cluster analysis identified four distinct groups reflecting different combinations of interoceptive sensibility and mindfulness. Profiles characterized by higher mindfulness consistently showed more adaptive eating patterns, including lower emotional and external eating and greater reliance on internal cues, regardless of interoceptive levels. In contrast, clusters with lower mindfulness showed higher levels of emotional eating and psychological distress. Within these low mindfulness profiles, high interoception was associated with lower depressive symptoms, lower eating disorder risk, and normal-weight status. These findings suggest that mindfulness was consistently associated with adaptive eating and psychological outcomes across profiles, whereas interoceptive sensibility further differentiated outcomes among profiles characterized by lower mindfulness. Overall, the results highlight the importance of considering both interoceptive sensibility and mindfulness jointly to better understand variability in eating behaviors and psychological distress. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Marinelli, L AU - Marinelli L AD - Univ. Bordeaux LabPsy, UR 4139, Bordeaux, F-33000, France; University Hospital Center of Bordeaux, Haut Leveque Hospital, Eating Disorders Unit, Pessac, 33600, France. Electronic address: lea.marinelli@u-bordeaux.fr. FAU - Berthoz, S AU - Berthoz S AD - Univ. Bordeaux, INCIA CNRS 5287, Bordeaux, 33000, France; Department of Psychiatry for Adolescents & Young Adults, Institut Medico-chirurgical (IMM), Paris, 75014, France. Electronic address: sylvie.berthoz-landron@inserm.fr. FAU - Decamps, G AU - Decamps G AD - Univ. Bordeaux LabPsy, UR 4139, Bordeaux, F-33000, France. Electronic address: greg.decamps@u-bordeaux.fr. FAU - Bourdier, L AU - Bourdier L AD - University Hospital Center of Bordeaux, Haut Leveque Hospital, Eating Disorders Unit, Pessac, 33600, France. Electronic address: lena.bourdier@chu-bordeaux.fr. FAU - Fatseas, M AU - Fatseas M AD - University Hospital Center of Bordeaux, Haut Leveque Hospital, Eating Disorders Unit, Pessac, 33600, France; Univ. Bordeaux, INCIA CNRS 5287, Bordeaux, 33000, France; CH Charles Perrens, Bordeaux, 33000, France. Electronic address: melina.fatseas@u-bordeaux.fr. FAU - Dantzer, C AU - Dantzer C AD - Univ. Bordeaux LabPsy, UR 4139, Bordeaux, F-33000, France. Electronic address: cecile.dantzer@u-bordeaux.fr. LA - eng PT - Journal Article DEP - 20260903 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Humans MH - Female MH - *Mindfulness MH - Male MH - Adult MH - *Feeding Behavior/psychology/physiology MH - *Interoception/physiology MH - France MH - Young Adult MH - *Psychological Distress MH - Middle Aged MH - Feeding and Eating Disorders/psychology MH - Cluster Analysis MH - Adolescent MH - *Stress, Psychological/psychology/physiopathology MH - Body Mass Index MH - Emotional Eating OTO - NOTNLM OT - Cluster analysis OT - Eating behavior OT - Interoceptive sensibility OT - Intuitive eating OT - Mindfulness COIS- Declaration of competing interest None. EDAT- 2026/09/08 23:35 MHDA- 2026/10/13 23:35 CRDT- 2026/09/08 18:16 PHST- 2025/02/03 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/10/13 23:35 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 18:16 [entrez] AID - S0022-3956(26)00427-9 [pii] AID - 10.1016/j.jpsychires.2026.09.001 [doi] PST - ppublish SO - J Psychiatr Res. 2026 Dec;203:51-59. doi: 10.1016/j.jpsychires.2026.09.001. Epub 2026 Sep 3. PMID- 42710439 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261013 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 203 DP - 2026 Dec TI - Treating sleep problems in children with Prader-Willi syndrome. PG - 33-40 LID - S0022-3956(26)00422-X [pii] LID - 10.1016/j.jpsychires.2026.08.025 [doi] AB - The purpose of the present study was to investigate the effects of a sleep treatment package on the frequency of night awakenings, bedtime resistance, and caregiver stress with the caregivers of three child participants diagnosed with Prader-Willi syndrome (PWS) using a multiple baseline across subjects design. During baseline, child participants were not exposed to any procedure. During intervention, caregivers implemented a treatment package including graduated extinction, bedtime routines, and bedtime fading without response cost. All interventions were previously successful with children diagnosed with autism spectrum disorder but had not been attempted with this population. Correct responding was defined as zero instances of night awakenings, zero instances of bedtime resistance (different for each child participant) and decreases in caregiver-reported stress. In addition, social validity was assessed using a Likert-style questionnaire. The results show that the treatment package had varying success across all participants, with the most success being for reducing behaviors at bedtime. These results will provide further understanding of the effect behavior-analytic approaches can have on children diagnosed with Prader-Willi syndrome, increasing the number of applications of applied behavior analysis and the supports available for caregivers of children diagnosed with PWS. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Weavers, Aliana AU - Weavers A AD - Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Canada. Electronic address: aweavers@brocku.ca. FAU - Kruse, Laura AU - Kruse L AD - The Chicago School, United States of America. LA - eng PT - Journal Article DEP - 20260904 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Humans MH - *Prader-Willi Syndrome/complications MH - *Sleep Wake Disorders/etiology/therapy MH - Child MH - Male MH - Female MH - Caregivers/psychology MH - *Behavior Therapy/methods MH - Surveys and Questionnaires MH - Treatment Outcome OTO - NOTNLM OT - Applied behaviour analysis OT - Children OT - Prader-willi syndrome OT - Sleep COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/08 23:35 MHDA- 2026/10/13 23:35 CRDT- 2026/09/08 18:16 PHST- 2026/02/06 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/10/13 23:35 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 18:16 [entrez] AID - S0022-3956(26)00422-X [pii] AID - 10.1016/j.jpsychires.2026.08.025 [doi] PST - ppublish SO - J Psychiatr Res. 2026 Dec;203:33-40. doi: 10.1016/j.jpsychires.2026.08.025. Epub 2026 Sep 4. PMID- 42709633 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260913 IS - 1545-8636 (Electronic) IS - 1546-0738 (Print) IS - 1545-8636 (Linking) VI - 75 IP - 6 DP - 2026 Sep 10 TI - Causes of Death Among Stillbirths and Children Aged <5 Years in Africa and South Asia - Child Health and Mortality Prevention Surveillance, Seven Countries, 2016-2024. PG - 1-24 LID - 10.15585/mmwr.ss7506a1 [doi] AB - PROBLEM/CONDITION: Sub-Saharan Africa and South Asia have the highest rates of stillbirths and rates of death among children aged <5 years, with many countries in those regions unlikely to meet the 2030 goal of ending preventable deaths among newborns and children aged <5 years. Conventional mortality surveillance (determining cause of death through interviews with family members or caregivers [i.e., verbal autopsy] and vital registration) in areas with high mortality often lacks laboratory confirmation of causes and incompletely identifies maternal contributors and comorbid conditions, providing information that is insufficiently specific to guide prevention efforts. PERIOD COVERED: December 2016-December 2024. DESCRIPTION OF SYSTEM: The Child Health and Mortality Prevention Surveillance (CHAMPS) network generates standardized, laboratory-confirmed data on causes and preventability of deaths among neonates, infants, and children aged <5 years and stillbirths in areas with high mortality. During 2016-2024, CHAMPS operated in seven countries (Bangladesh, Ethiopia, Kenya, Mali, Mozambique, Sierra Leone, and South Africa) through population-defined catchment areas. Eligibility required residence in a CHAMPS catchment area for >/=4 months before death or, for children aged <4 months, since birth. Deaths were investigated using a standardized postmortem approach that included minimally invasive tissue sampling (MITS), laboratory investigations (conventional and molecular microbiology and histopathology), interviews with family members or caregivers (i.e., verbal autopsy), and pediatric and maternal clinical record abstraction. Multidisciplinary determination of cause-of-death (DeCoDe) panels integrated evidence to assign causes (including multiple causes per death) and assess preventability. RESULTS: During 2016-2024, a total of 18,784 eligible deaths were identified; families consented to CHAMPS enrollment for 15,612 (83.1%) of these deaths. MITS was completed for 9,415 deaths and DeCoDe was completed for 8,500 (90.3% of MITS-investigated deaths); a total of 3,199 (37.6%) were stillbirths; 3,230 (38.0%) were neonatal deaths; and 2,071 (24.4%) were deaths of infants (aged 28 days to <12 months) and children (aged >/=12 to <60 months). Stillbirths were predominantly attributed to perinatal asphyxia or hypoxia (79.1%), often with maternal hypertensive disorders, placental abnormalities, chorioamnionitis, and other medical conditions (e.g., diabetes). Neonatal deaths involved preterm complications (39.7%); asphyxia or hypoxia (37.7%), which often is linked to maternal and intrapartum care; and sepsis (36.5%), commonly resulting from infection with Klebsiella pneumoniae and Acinetobacter baumannii. Among infants and children, leading causes of death included lower respiratory infections (37.4%), sepsis (36.9%), malnutrition (27.3%), malaria (22.1%), and diarrheal disease (17.3%). Multiple conditions in the causal chain were common among neonates (44.3% with two or more conditions) and infants and children (67.9% with two or more conditions). Postmortem anthropometry indicated high levels of moderate or severe undernutrition among infants and children; among those with available measurements, nonmutually exclusive anthropometric indicators included underweight (61.3%), wasting (61.3%), and stunting (43.0%), according to the World Health Organization's Child Growth Standards. Among neonatal, infant, and child deaths (excluding stillbirths), infection contributed to 3,146 (59.3%) deaths. Among neonatal, infant, and child deaths with one or more pathogens identified in the causal chain (n = 2,749), 44.5% were polymicrobial, with gram-negative bacteria predominating. Main maternal conditions, most commonly placental complications and hypertensive disorders of pregnancy, were assigned for 71.1% of stillbirths and 58.2% of neonatal deaths. Of 7,558 deaths with a preventability assessment, 6,103 (80.7%) were considered preventable or possibly preventable through improvements in already available maternal, newborn, and child health interventions; primary opportunities included strengthened antenatal care, obstetric management, and infection control. INTERPRETATION: CHAMPS complements conventional mortality surveillance by providing standardized, laboratory-confirmed, postmortem evidence on causes and preventability of stillbirths and of deaths among neonates, infants, and children aged <5 years across areas with high mortality. Findings demonstrate that preventable infections, suboptimal antenatal care, intrapartum complications, preterm birth, and malnutrition account for most deaths and also involve maternal and health care system factors. The predominance of infections caused by gram-negative bacteria highlights the need to strengthen infection prevention and control and to develop preventive tools, including vaccines. PUBLIC HEALTH ACTION: Four of every five deaths were potentially preventable with timely implementation of established maternal, newborn, and child health interventions. CHAMPS demonstrates that high-precision postmortem MITS is feasible in resource-constrained settings and provides data critical to improve maternal and child health planning, practice, and policy. Certain components of CHAMPS (e.g., standardized MITS training, targeted diagnostics, and multidisciplinary review) could be adapted to strengthen routine surveillance and mortality review systems where feasible. FAU - Madewell, Zachary J AU - Madewell ZJ FAU - Dangor, Ziyaad AU - Dangor Z FAU - Mutevedzi, Portia C AU - Mutevedzi PC FAU - Johnstone, Siobhan L AU - Johnstone SL FAU - Lala, Sanjay G AU - Lala SG FAU - Madhi, Shabir A AU - Madhi SA FAU - Velaphi, Sithembiso AU - Velaphi S FAU - Assefa, Nega AU - Assefa N FAU - Kebede, Meron AU - Kebede M FAU - Madrid, Lola AU - Madrid L FAU - Marami, Dadi AU - Marami D FAU - Scott, J Anthony G AU - Scott JAG FAU - Aol, George AU - Aol G FAU - Igunza, Kitiezo Aggrey AU - Igunza KA FAU - Muttai, Hellen AU - Muttai H FAU - Onyango, Peter Nyamthimba AU - Onyango PN FAU - Otieno, Peter O AU - Otieno PO FAU - Bassat, Quique AU - Bassat Q FAU - Garrine, Marcelino AU - Garrine M FAU - Kincardett, Milton AU - Kincardett M FAU - Mandomando, Inacio AU - Mandomando I FAU - Nhacolo, Ariel AU - Nhacolo A FAU - Juma, Jane AU - Juma J FAU - Keita, Adama Mamby AU - Keita AM FAU - Kotloff, Karen L AU - Kotloff KL FAU - Sow, Samba O AU - Sow SO FAU - Tapia, Milagritos D AU - Tapia MD FAU - Afrin, Afsana AU - Afrin A FAU - El Arifeen, Shams AU - El Arifeen S FAU - Biswas, Rajib AU - Biswas R FAU - Gurley, Emily S AU - Gurley ES FAU - Hossain, Mohammad Zahid AU - Hossain MZ FAU - Ameh, Soter AU - Ameh S FAU - Bassey, Ima-Abasi AU - Bassey IA FAU - Kaluma, Erick AU - Kaluma E FAU - Kowuor, Dickens AU - Kowuor D FAU - Ogbuanu, Ikechukwu Udo AU - Ogbuanu IU FAU - Bhatnagar, Julu AU - Bhatnagar J FAU - Blau, Dianna M AU - Blau DM FAU - Clarke, Kevin R AU - Clarke KR FAU - Diaz, Maureen H AU - Diaz MH FAU - Dynes, Michelle AU - Dynes M FAU - Kasten, Jennifer AU - Kasten J FAU - Martines, Roosecelis B AU - Martines RB FAU - McGee, Lesley AU - McGee L FAU - Morof, Diane F AU - Morof DF FAU - Sage, Elizabeth O'Mara AU - Sage EO FAU - Raghunathan, Pratima L AU - Raghunathan PL FAU - Ritter, Jana AU - Ritter J FAU - Shieh, Wun-Ju AU - Shieh WJ FAU - Taylor, Allan W AU - Taylor AW FAU - Velusamy, Srinivasan AU - Velusamy S FAU - Verani, Jennifer R AU - Verani JR FAU - Wadhwa, Ashutosh AU - Wadhwa A FAU - Waller, Jessica L AU - Waller JL FAU - Winchell, Jonas AU - Winchell J FAU - Witherbee, Jacob S AU - Witherbee JS FAU - Worrell, Mary-Claire AU - Worrell MC FAU - Akelo, Victor AU - Akelo V FAU - Koplan, Jeffrey P AU - Koplan JP FAU - Breiman, Robert F AU - Breiman RF FAU - Whitney, Cynthia G AU - Whitney CG LA - eng PT - Journal Article DEP - 20260910 PL - United States TA - MMWR Surveill Summ JT - Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) JID - 101142015 SB - IM MH - Humans MH - Cause of Death/trends MH - Infant MH - Child, Preschool MH - *Stillbirth/epidemiology MH - Female MH - Infant, Newborn MH - *Population Surveillance MH - *Child Mortality/trends MH - Asia, Southern/epidemiology MH - Male MH - Africa/epidemiology MH - Infant Mortality/trends MH - Child Health/statistics & numerical data PMC - PMC13564208 COIS- All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Pratima L. Raghunathan reports performing unpaid service on the World Health Organization African Regional Immunization Technical Advisory Group during 2023-2026 and for grant proposal development for the Task Force for Global Health in 2026. J. Anthony G. Scott reports institutional support from the Wellcome Trust, National Institute for Health and Care Research, the Coalition for Epidemic Preparedness Innovations, the Foreign, Commonwealth and Development Office, and the Bill & Melinda Gates Foundation for projects other than Child Health and Mortality Prevention Surveillance (CHAMPS); receipt of a travel grant from the Kenes Group to attend the 2024 meeting of the International Society of Pneumonia and Pneumococcal Diseases; receipt of funding from PATH for SII PCV10 (Synflorix) trial in The Gambia; and receipt of funding from Iliad for trial of a mucosal pertussis vaccine in children. Cynthia G. Whitney reports institutional grant funding from the Bill & Melinda Gates Foundation to Emory University while she was affiliated with Emory University, for projects in addition to CHAMPS. Karen L. Kotloff reports institutional support from Emory University and the Bill & Melinda Gates Foundation and serving as an unpaid chairperson for the University of California, San Francisco, Data Safety and Monitoring Board AMOUR. Shabir A. Madhi and Ziyaad Dangor report institutional support from the Bill & Melinda Gates Foundation for projects in addition to CHAMPS. Shabir A. Madhi also reports institutional support from GSK, Pfizer, MinervaX, and Merck; receipt of lecture honoraria from GSK and Pfizer; and serving as chairperson on the Rotavirus Vaccine Data Safety and Monitoring Board for PATH and the Modified Vaccinia Ankara Data Safety and Monitoring Board for Bavarian Nordic. Shams El Arifeen reports receipt of direct travel support from the Bill & Melinda Gates Foundation to attend a meeting on improved cause-of-death approaches outside of CHAMPS. EDAT- 2026/09/08 17:36 MHDA- 2026/09/08 17:37 PMCR- 2026/09/10 CRDT- 2026/09/08 13:04 PHST- 2026/09/08 17:37 [medline] PHST- 2026/09/08 17:36 [pubmed] PHST- 2026/09/08 13:04 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - ss7506a1 [pii] AID - 10.15585/mmwr.ss7506a1 [doi] PST - epublish SO - MMWR Surveill Summ. 2026 Sep 10;75(6):1-24. doi: 10.15585/mmwr.ss7506a1. PMID- 42709217 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20261025 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 7 DP - 2026 Sep 8 TI - Association of the maternal fish and PUFA intake with the risk of hypertensive disorders of pregnancy: a nationwide birth cohort-The Japan Environment and Children's Study (JECS). LID - 10.1007/s00394-026-04103-7 [doi] LID - 249 AB - PURPOSE: Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and perinatal morbidity. Although n-3 polyunsaturated fatty acids (PUFAs) in fish may prevent HDP, evidence from Japanese populations, particularly regarding the preconception period, remains limited. To examine associations between fish and PUFA intake before and during pregnancy and the risk of HDP using data from a nationwide Japanese birth cohort. METHODS: This analysis included 86,009 women from the Japan Environment and Children's Study. Dietary fish and n-3/n-6 PUFAs intake was assessed using a validated food-frequency questionnaire administered in early pregnancy (median gestational age, 15.0 weeks [interquartile range (IQR) 12.0-19.0]) to capture intake before pregnancy, and in mid to late pregnancy (median gestational age, 27.0 weeks [IQR 25.0-30.0]). Participants were categorized into quintiles of intake. Logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for HDP, early-onset HDP (Eo-HDP < 32 weeks), and late-onset HDP (Lo-HDP >/= 32 weeks). Missing data were addressed with multiple imputation. RESULTS: In the overall population, higher fish intake before pregnancy was associated with reduced risks of Eo-HDP in the Q5 groups, whereas higher fish intake during pregnancy was associated with reduced risks of overall HDP in Q4. In analyses restricted to nulliparous women, higher pre-pregnancy fish intake was associated with a lower risk of Eo-HDP (Q4: aOR 0.57; 95% CI 0.34-0.97; p for trend = 0.02), and higher fish intake during pregnancy was associated with a lower risk of Lo-HDP (Q4: aOR 0.79; 95% CI 0.64-0.96). Total n-3 PUFA intake showed significant associations with HDP only in some analyses. Sensitivity analyses using a 34-week cutoff yielded consistent results. CONCLUSION: Fish intake before pregnancy was associated with lower risk of Eo-HDP, whereas intake during pregnancy was linked to reduced risk of Lo-HDP. Sustained fish consumption from preconception through pregnancy may help prevent HDP and inform global nutritional guidance, including preconception care. TRIAL REGISTRATION: The Japan Environment and Children's Study, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000035091 (Registration no. UMIN000030786). CI - (c) 2026. The Author(s). FAU - Inouye, Takuya AU - Inouye T AUID- ORCID: 0009-0008-9827-6887 AD - Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Gunma, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. FAU - Higeta, Daisuke AU - Higeta D AUID- ORCID: 0000-0002-6981-9722 AD - Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Gunma, Japan. FAU - Hamazaki, Kei AU - Hamazaki K AUID- ORCID: 0000-0003-0456-6805 AD - Department of Public Health Faculty of Medicine, Gunma University Graduate School of Medicine, Showa 3 Maebashi, Gunma, Japan. kei.hamazaki@gunma-u.ac.jp. AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. kei.hamazaki@gunma-u.ac.jp. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. kei.hamazaki@gunma-u.ac.jp. FAU - Iwase, Akira AU - Iwase A AUID- ORCID: 0000-0002-0031-884X AD - Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Gunma, Japan. FAU - Tsuchida, Akiko AU - Tsuchida A AUID- ORCID: 0000-0003-1209-3104 AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. FAU - Inadera, Hidekuni AU - Inadera H AUID- ORCID: 0000-0002-3548-221X AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. FAU - Yoshioka, Eiji AU - Yoshioka E AUID- ORCID: 0000-0003-3316-1057 AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. CN - Japan Environment and Children's Study Group LA - eng PT - Journal Article DEP - 20260908 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 RN - 0 (Fatty Acids, Omega-3) RN - 0 (Fatty Acids, Omega-6) SB - IM MH - Female MH - Humans MH - Pregnancy MH - Japan/epidemiology MH - Animals MH - *Hypertension, Pregnancy-Induced/epidemiology/prevention & control MH - Adult MH - *Seafood MH - *Fishes MH - *Fatty Acids, Omega-3/administration & dosage MH - *Diet/methods MH - Birth Cohort MH - *Fatty Acids, Omega-6/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - Risk Factors MH - Odds Ratio MH - Cohort Studies MH - Logistic Models MH - Surveys and Questionnaires MH - Gestational Age PMC - PMC13553602 OTO - NOTNLM OT - Birth cohort OT - Fish OT - Hypertensive disorder of pregnancy OT - Polyunsaturated fatty acids OT - Preconception care COIS- Declarations. Competing interests: KH has received lecture honoraria from Sumitomo Pharma Co., Ltd., Suntory Wellness Ltd., JCR Pharmaceuticals Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Pfizer Japan Inc., and Kensho Pharmaceutical Co., Ltd., for presentations related to n-3 PUFAs. All other authors report no conflicts of interest. Declaration of Generative AI and AI-assisted technologies in the writing process: During the preparation of this manuscript, the authors did not use any generative artificial intelligence or AI-assisted technologies for writing, editing, or content generation. The authors take full responsibility for the integrity and originality of the content.ss EDAT- 2026/09/08 17:36 MHDA- 2026/09/08 17:37 PMCR- 2026/09/08 CRDT- 2026/09/08 11:19 PHST- 2026/05/06 00:00 [received] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/08 17:37 [medline] PHST- 2026/09/08 17:36 [pubmed] PHST- 2026/09/08 11:19 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.1007/s00394-026-04103-7 [pii] AID - 4103 [pii] AID - 10.1007/s00394-026-04103-7 [doi] PST - epublish SO - Eur J Nutr. 2026 Sep 8;65(7):249. doi: 10.1007/s00394-026-04103-7. PMID- 42708126 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2523-2754 (Electronic) IS - 2310-2594 (Print) IS - 2523-2794 (Linking) VI - 14 IP - 3 DP - 2026 Jul-Sep TI - Development and validation of a Spanish-language questionnaire to assess mothers' knowledge and practices regarding their children's oral health. PG - e299 LID - 10.21142/2523-2754-1403-2026-299 [doi] LID - e299 AB - OBJECTIVE: This study aimed to design and validate a Spanish-language questionnaire to assess mothers' knowledge and practices regarding their children's oral health. MATERIAL AND METHODS: An exploratory study with a descriptive scope was conducted using both quantitative and qualitative data collection techniques and instruments, following these phases: 1) Review of relevant scientific literature; 2) Identification of core items and development of the preliminary instrument; 3) Preliminary pilot testing with an expert panel; 4) Semantic testing of the questionnaire in the target population; 5) Assessment of the instrument's reliability and reproducibility; 6) Validation of the instrument's appearance and content through two rounds with subject matter experts, including the calculation of various validity indicators: Content Validity Index (CVI), Content Validity Ratio (CVR), and Content Validity Coefficient (CVC). RESULTS: An assessment instrument was developed comprising 31 items that capture information across three dimensions: 1) psychosocial (attitudinal and relational); 2) knowledge; and 3) practices. All dimensions addressed aspects related to breastfeeding and nutrition, hygiene, and oral health within the mother-child dyad. Expert validation rounds produced CVI, CVR, and CVC values calculated for each item (I), dimension (S), and for the overall instrument (S). All scores exceeded the established thresholds (CVI >/= 0.78/0.90; CVR >/= 0.37/0.70; and CVC >/= 0.90), indicating adequate content validity. Minor wording and structural adjustments were made to some questions based on expert feedback. CONCLUSION: This study resulted in the development of a Spanish-language assessment instrument with adequate content and face validity, which is useful for designing educational strategies targeting the mother-child dyad to promote proper oral health. FAU - Arias-Mendoza, Martha J AU - Arias-Mendoza MJ AUID- ORCID: 0000-0003-2406-946X AD - Faculty of Dentistry, Universidad Santo Tomas. Santander, Colombia. ethman.torres@ustabuca.edu.co Universidad Santo Tomas Faculty of Dentistry Universidad Santo Tomas Santander Colombia ethman.torres@ustabuca.edu.co. FAU - Agudelo-Suarez, Andres A AU - Agudelo-Suarez AA AUID- ORCID: 0000-0002-8079-807X AD - Faculty of Dentistry, Universidad Cooperativa de Colombia. Medellin, Colombia. alonso.agudelo@udea.edu.co, emilia.ochoa@campusucc.edu.co Universidad Cooperativa de Colombia Faculty of Dentistry Universidad Cooperativa de Colombia Medellin Colombia alonso.agudelo@udea.edu.co emilia.ochoa@campusucc.edu.co. FAU - Ochoa-Acosta, Emilia M AU - Ochoa-Acosta EM AUID- ORCID: 0000-0001-6765-5712 AD - Faculty of Dentistry, Universidad Cooperativa de Colombia. Medellin, Colombia. alonso.agudelo@udea.edu.co, emilia.ochoa@campusucc.edu.co Universidad Cooperativa de Colombia Faculty of Dentistry Universidad Cooperativa de Colombia Medellin Colombia alonso.agudelo@udea.edu.co emilia.ochoa@campusucc.edu.co. FAU - Torres-Murillo, Ethman A AU - Torres-Murillo EA AUID- ORCID: 0000-0003-1603-8380 AD - Faculty of Dentistry, Universidad Santo Tomas. Santander, Colombia. ethman.torres@ustabuca.edu.co Universidad Santo Tomas Faculty of Dentistry Universidad Santo Tomas Santander Colombia ethman.torres@ustabuca.edu.co. FAU - Concha-Sanchez, Sonia C AU - Concha-Sanchez SC AUID- ORCID: 0000-0003-3092-520X AD - Public Health Department, Universidad de Santander. Bucaramanga, Colombia. sococosa@yahoo.com Universidad de Santander Public Health Department Universidad de Santander Bucaramanga Colombia sococosa@yahoo.com. LA - eng PT - Journal Article DEP - 20260710 PL - Peru TA - Rev Cient Odontol (Lima) JT - Revista cientifica odontologica (Universidad Cientifica del Sur) JID - 9918697384606676 PMC - PMC13549665 OTO - NOTNLM OT - Health Education OT - Health Knowledge, Attitudes, Practice OT - Health Promotion OT - Oral Health OT - Validation Study COIS- Conflict of Interest: The authors declare no conflict of interest related to this study. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/07/10 CRDT- 2026/09/08 06:52 PHST- 2025/12/11 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 06:52 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.21142/2523-2754-1403-2026-299 [doi] PST - epublish SO - Rev Cient Odontol (Lima). 2026 Jul 10;14(3):e299. doi: 10.21142/2523-2754-1403-2026-299. eCollection 2026 Jul-Sep. PMID- 42707981 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Enhancing healthy eating and active environments in early learning settings: findings from the eHealth study. PG - 1873291 LID - 10.3389/fnut.2026.1873291 [doi] LID - 1873291 AB - INTRODUCTION: Early childhood educators are important influencers of children's eating and activity behaviors, making them key targets for interventions aimed at improving nutrition and physical activity practices and fostering healthier childcare environments. OBJECTIVE: To evaluate the impact of the eHealth professional development program in improving early childhood education and care (ECEC) nutrition and physical activity environments, educators' nutrition knowledge, attitudes, and behaviors, and educators' perceptions of program acceptability. METHOD: This study was conducted in licensed ECEC centers in one Canadian province. The study used a two-armed quasi-experimental pre-test/post-test design with intervention and control groups and repeated measures to evaluate a 10-month eHealth program informed by Social Cognitive Theory and the Interconnected Model of Professional Growth Theory. The program aimed to enhance educators' capacity to implement evidence-based nutrition and physical activity practices. Delivered in annual cohorts from 2019 to 2021, it comprised two phases: (1) a 12-week series of online educational modules with accompanying virtual Communities of Practice meetings, and (2) a five-month follow-up period involving monthly implementation-coaching virtual Communities of Practice meetings. Validated questionnaires assessed center-level and educator-level outcomes at baseline, five (midpoint), and 10 months (end-of-program). Semi-structured interviews explored perceptions of program acceptability. RESULTS: Compared with controls, significant improvements in center-level nutrition and physical activity environments (mean change 0.362, p = 0.002, Cohen's d = 0.72), and educator nutrition knowledge, attitudes, and behaviors (mean change 5.467, p = 0.023, Cohen's d = 0.69) were observed at midpoint and maintained at the end-of-program. Qualitative findings indicated high acceptability, with educators describing the program as relevant, feasible, and supportive of integrating practices into daily routines. CONCLUSION: The eHealth professional development program was acceptable and associated with improvements in educators' knowledge and adherence to nutrition and physical activity practice guidelines, with sustained effect over time. Scalable, digitally delivered professional development may offer a promising strategy to support healthier ECEC environments. CI - Copyright (c) 2026 Lafave, Hayek, McConnell and Winkens. FAU - Lafave, Lynne M Z AU - Lafave LMZ AD - CHEERS Lab, Department Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - Hayek, Joyce AU - Hayek J AD - CHEERS Lab, Department Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - McConnell, Ceilidh AU - McConnell C AD - CHEERS Lab, Department Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - Winkens, Bjorn AU - Winkens B AD - Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Department of Methodology and Statistics, Maastricht University, Maastricht, Netherlands. LA - eng PT - Journal Article DEP - 20260824 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13548801 OTO - NOTNLM OT - eHealth intervention OT - early childhood education and care OT - interconnected model of professional growth OT - linear mixed models OT - nutrition OT - physical activity OT - professional development OT - social cognitive theory COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/08/24 CRDT- 2026/09/08 06:41 PHST- 2026/05/05 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 06:41 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1873291 [doi] PST - epublish SO - Front Nutr. 2026 Aug 24;13:1873291. doi: 10.3389/fnut.2026.1873291. eCollection 2026. PMID- 42707971 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Artificial intelligence in child nutrition and eating behavior: from prediction to gastronomic mediation. PG - 1952364 LID - 10.3389/fnut.2026.1952364 [doi] LID - 1952364 AB - Artificial intelligence (AI) is entering child nutrition through dietary assessment, malnutrition forecasting, clinical decision support, meal recommendation, conversational interventions, and food-environment monitoring. The consequences of these applications converge in everyday eating. This Mini Review synthesizes evidence on how AI measures nutritional states and mediates food choice, communication, sensory acceptance, family practice, and digital exposure. The evidence supports two connected functions. As nutritional intelligence, AI converts clinical, dietary, and environmental data into assessments or predictions. As gastronomic mediation, it participates in decisions about what foods are noticed, recommended, prepared, discussed, and accepted. Direct pediatric validation is strongest for bounded assessment and forecasting tasks. Child meal-planning studies and generative-AI evaluations based on standardized adolescent profiles reveal a gap between nutrient optimization, culinary coherence, and nutritional safety. A large adolescent chatbot trial combined scalable delivery with null intention-to-treat effects on diet quality and BMI trajectory. Co-design and behavioral studies further identify familiarity, texture, participation, and caregiver involvement as central design variables. We propose five iterative translational gates: technical validity, nutritional validity, behavioral acceptability, contextual legitimacy, and real-world effectiveness and implementation. Future research should combine age-specific nutritional constraints with sensory and cultural knowledge, evaluate performance across food cultures, preserve professional and caregiver oversight, and test outcomes in homes, schools, clinics, and digital food environments. AI can advance child-focused gastronomy by translating computational outputs into safe, culturally meaningful, and developmentally appropriate eating practices. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article PT - Review DEP - 20260824 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13548810 OTO - NOTNLM OT - artificial intelligence OT - child nutrition OT - child-centered design OT - digital food environment OT - eating behavior OT - food culture OT - gastronomy OT - personalized nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/08/24 CRDT- 2026/09/08 06:38 PHST- 2026/07/29 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 06:38 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1952364 [doi] PST - epublish SO - Front Nutr. 2026 Aug 24;13:1952364. doi: 10.3389/fnut.2026.1952364. eCollection 2026. PMID- 42707362 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutrition education and behavioral interventions in youth team-sport and related development settings: a systematic review of nutrition knowledge, dietary behaviors, hydration, body composition, and performance. PG - 1939289 LID - 10.3389/fnut.2026.1939289 [doi] LID - 1939289 AB - INTRODUCTION: Nutrition knowledge and the ability to translate it into appropriate food and hydration choices are important for health, development, recovery, and performance in young athletes. However, evidence on nutrition interventions in youth team-sport settings remains dispersed across sports, educational formats, and outcome domains. This systematic review aimed to synthesize evidence on nutrition education, hydration education, dietary counseling, digital tools, controlled dietary modification, and multicomponent interventions in child, adolescent, and late-adolescent development settings. METHODS: The review followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD420261441507). PubMed/MEDLINE, Scopus, Web of Science Core Collection, SPORTDiscus/EBSCO, and Cochrane CENTRAL were searched from inception to 3 July 2026. Two reviewers independently screened reports, extracted data, and assessed risk of bias using RoB 2 or ROBINS-I. Because of substantial heterogeneity in interventions and outcomes, findings were synthesized narratively. RESULTS: Database searches identified 419 records. After duplicate removal and screening, 46 full-text reports were assessed, 19 were excluded, and 27 unique studies were included. Soccer/football predominated, with additional evidence from volleyball, basketball, handball, baseball, hockey, American football, and mixed-sport settings. Nutrition and sports nutrition knowledge showed the most consistent favorable changes. Findings for dietary intake, diet quality, body composition, biochemical markers, and performance were mixed. Hydration interventions showed clearer short-term improvements when education was combined with practical cues, improved fluid access, feedback, or individualized prescriptions. DISCUSSION: Nutrition interventions in youth team-sport and related development settings may support knowledge acquisition and selected hydration behaviors, but their effects on dietary behavior and physiological outcomes remain uncertain. Confidence in the evidence is limited by small samples, short follow-up periods, heterogeneous measures, reliance on self-report, incomplete fidelity reporting, and risk-of-bias concerns. Future trials should use validated age-appropriate measures, objective outcomes, longer follow-up, prespecified analyses, and implementation strategies involving athletes, families, coaches, schools, and clubs. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261441507, CRD420261441507. CI - Copyright (c) 2026 Victoria-Montesinos, Garcia-Munoz, Mercader-Ros, Jaraba-Salinero and Figueroa-Morales. FAU - Victoria-Montesinos, Desiree AU - Victoria-Montesinos D AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Garcia-Munoz, Ana Maria AU - Garcia-Munoz AM AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Mercader-Ros, Maria Teresa AU - Mercader-Ros MT AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Jaraba-Salinero, Yasmina AU - Jaraba-Salinero Y AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Figueroa-Morales, Fernando AU - Figueroa-Morales F AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260824 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13547255 OTO - NOTNLM OT - adolescents OT - body composition OT - children OT - dietary behavior OT - nutrition education OT - nutrition knowledge OT - sport performance OT - sports nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author DV-M declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/08/24 CRDT- 2026/09/08 05:37 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 05:37 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1939289 [doi] PST - epublish SO - Front Nutr. 2026 Aug 24;13:1939289. doi: 10.3389/fnut.2026.1939289. eCollection 2026. PMID- 42706948 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260917 IS - 1654-9880 (Electronic) IS - 1654-9716 (Print) IS - 1654-9880 (Linking) VI - 19 IP - 1 DP - 2026 Dec TI - Implementing school-based nutrition interventions in low- and middle-income countries: a scoping review of implementation strategies, frameworks, and outcomes. PG - 2727312 LID - 10.1080/16549716.2026.2727312 [doi] LID - 2727312 AB - School-based nutrition interventions are widely used to improve nutrition among children and adolescents in low- and middle-income countries. This scoping review examined implementation strategies, theories, models, frameworks, and implementation outcomes reported for school-based nutrition interventions in these settings. We included English-language primary studies conducted in school settings in low- and middle-income countries if they reported implementation strategies, implementation outcomes, theories, models or frameworks, barriers, facilitators, adaptation, sustainability, scale-up, or implementation processes. PubMed and Scopus were searched, and reference lists of included studies and relevant reviews were screened. Records were screened independently by two reviewers, and data were synthesized descriptively and thematically. The search identified 1,985 records, and eight studies met the inclusion criteria. The studies were conducted in Nepal, Ghana, Pakistan, Tanzania, and India. Implementation strategies included teacher-led delivery, training, stakeholder and community engagement, external partnership support, and integration into school systems. Reported barriers included limited funding, inadequate infrastructure, staff workload, weak coordination, limited monitoring, and dependence on external or parent contributions. Separately, implementation reporting was incomplete, particularly for reach, fidelity, and sustainability. Because the search was restricted to two databases and English-language publications, some relevant evidence may have been missed. Future studies should report implementation processes and outcomes more clearly to support adaptation, scale-up, and long-term delivery. FAU - Kamyshnyi, Oleksandr AU - Kamyshnyi O AD - Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine. FAU - Halabitska, Iryna AU - Halabitska I AD - Department of Therapy and Family Medicine, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine. FAU - Petakh, Pavlo AU - Petakh P AD - Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine. FAU - Bhattarai, Sanju AU - Bhattarai S AD - Institute for Implementation Science and Health, Kathmandu, Nepal. FAU - Sen, Abhijit AU - Sen A AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. AD - Center for Oral Health Services and Research (TkMidt), Trondheim, Norway. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Scoping Review DEP - 20260908 PL - United States TA - Glob Health Action JT - Global health action JID - 101496665 SB - IM MH - Humans MH - *Developing Countries MH - *School Health Services/organization & administration MH - Child MH - Adolescent MH - Schools MH - *Health Promotion/organization & administration/methods PMC - PMC13556112 OAB - Main findings: Several included studies reported school-based nutrition interventions as feasible or acceptable, while also identifying barriers related to unstable funding, limited infrastructure, staff workload, poor coordination, limited monitoring, and dependence on external or parent contributions.Added knowledge: This review shows that implementation strategies, frameworks, reach, fidelity, and sustainability are not reported in enough detail in studies of school-based nutrition interventions in low- and middle-income countries.Global health impact for policy and action: The reviewed evidence identifies financing, infrastructure, staff training, coordination, monitoring, and community engagement as priorities for further implementation research and context-specific programme planning. OABL- eng OTO - NOTNLM OT - School-based nutrition OT - children and adolescents OT - implementation outcomes OT - implementation strategies OT - low- and middle-income countries COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/09/08 05:36 MHDA- 2026/09/08 05:37 PMCR- 2026/09/08 CRDT- 2026/09/08 04:02 PHST- 2026/09/08 05:37 [medline] PHST- 2026/09/08 05:36 [pubmed] PHST- 2026/09/08 04:02 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 2727312 [pii] AID - 10.1080/16549716.2026.2727312 [doi] PST - ppublish SO - Glob Health Action. 2026 Dec;19(1):2727312. doi: 10.1080/16549716.2026.2727312. Epub 2026 Sep 8. PMID- 42706523 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260910 IS - 1471-2466 (Electronic) IS - 1471-2466 (Linking) VI - 26 IP - 1 DP - 2026 Sep 7 TI - Moving beyond treatment: pulmonary function, autonomous motivation, and physical activity enjoyment in adults with cystic fibrosis. LID - 10.1186/s12890-026-04661-w [doi] LID - 400 AB - BACKGROUND: Physical activity (PA) and structured exercise are established cornerstones of cystic fibrosis (CF) management. While CFTR modulators have transformed treatment, the psychological factors affecting sustained PA adherence, particularly motivational regulation and PA enjoyment, require further investigation. This study aimed to determine whether percent predicted forced expiratory volume in one second (ppFEV(1)) is independently associated with autonomous motivation and PA enjoyment in adults with CF, after adjusting for CFTR modulator therapy status and sex. METHODS: A cross-sectional study was conducted at a specialised CF centre (N = 200). Participants completed validated questionnaires assessing motivational regulation (Behavioural Regulation Questionnaire-2, BREQ-2) and PA enjoyment (Physical Activity Enjoyment Scale, PACES). Clinical data, including the ppFEV(1), were obtained from medical records. Multivariate general linear models (GLM), partial correlations, and hierarchical regression analyses were utilised. RESULTS: Cross-sectional analyses showed that ppFEV(1) was independently associated with intrinsic motivation (beta = .233, p < .001), the relative autonomy index (RAI) (beta = .203, p = .004) and the PACES total score (beta = .201, p = .004). After CFTR modulator therapy status and sex were accounted for, the additional variance explained by the ppFEV(1) was statistically significant but modest (DeltaR(2) = .054, .041, and .040, respectively). Neither the CFTR modulator therapy status nor sex was significantly associated with the assessed motivational or enjoyment outcomes. CONCLUSIONS: Although ppFEV(1) showed small, independent associations with autonomous motivational regulation and PA enjoyment in adults with CF, lung function should not be used as a proxy for motivational support needs. To provide person-centred, SDT-informed support that encourages sustained participation in PA, the motivational regulation and enjoyment of PA should be assessed directly in adults with CF. CI - (c) 2026. The Author(s). FAU - Gruber, Wolfgang AU - Gruber W AUID- ORCID: 0000-0003-2186-9269 AD - Paediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Centre, Children S Hospital, University of Duisburg-Essen, 45147, Essen, Germany. wolfgang.gruber@uk-essen.de. AD - Fachklinik Satteldune der DRV Nord, Nebel/Amrum, Germany. wolfgang.gruber@uk-essen.de. FAU - Welsner, Matthias AU - Welsner M AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Stehling, Florian AU - Stehling F AD - Paediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Centre, Children S Hospital, University of Duisburg-Essen, 45147, Essen, Germany. FAU - Schermaul, Jin-Sun AU - Schermaul JS AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Ortiz, Jose G AU - Ortiz JG AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Lechtenberg, Liron AU - Lechtenberg L AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Taube, Christian AU - Taube C AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Olivier, Margarete AU - Olivier M AD - Paediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Centre, Children S Hospital, University of Duisburg-Essen, 45147, Essen, Germany. LA - eng PT - Journal Article DEP - 20260907 PL - England TA - BMC Pulm Med JT - BMC pulmonary medicine JID - 100968563 SB - IM MH - Humans MH - *Motivation MH - Male MH - Female MH - Cross-Sectional Studies MH - *Cystic Fibrosis/psychology/physiopathology/therapy MH - Adult MH - Forced Expiratory Volume MH - Surveys and Questionnaires MH - *Exercise/psychology MH - Young Adult MH - Linear Models MH - Adolescent PMC - PMC13548599 OTO - NOTNLM OT - Autonomous motivation OT - CFTR modulator therapy OT - Cystic fibrosis OT - Physical activity enjoyment OT - Pulmonary function OT - Self-determination theory OT - Sex COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of the University of Duisburg-Essen (24-11951-BO). Written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/08 05:36 MHDA- 2026/09/08 05:37 PMCR- 2026/09/07 CRDT- 2026/09/08 00:06 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/08 05:37 [medline] PHST- 2026/09/08 05:36 [pubmed] PHST- 2026/09/08 00:06 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.1186/s12890-026-04661-w [pii] AID - 4661 [pii] AID - 10.1186/s12890-026-04661-w [doi] PST - epublish SO - BMC Pulm Med. 2026 Sep 7;26(1):400. doi: 10.1186/s12890-026-04661-w. PMID- 42705712 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260929 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 243 IP - Pt 2 DP - 2026 Nov 1 TI - Sheep milk proteins: current research on nutritional characteristics, biofunctional properties, and application potentials. PG - 120247 LID - S0963-9969(26)01934-4 [pii] LID - 10.1016/j.foodres.2026.120247 [doi] AB - BACKGROUND: Sheep milk proteins (SMPs) are key nutritional and functional components of sheep milk and have attracted increasing interest because of their high digestibility, distinctive compositional profile, and reported bioactivities. Compared with bovine milk proteins, SMPs contain a high proportion of beta-casein, relatively low alphas1-casein, and multiple low-abundance bioactive proteins and peptides. However, their high value utilization remains limited by uneven global milk supply, raw-material variability, challenges in separation and purification, and insufficient in vivo and clinical evidence. SCOPE AND APPROACH: This review focuses specifically on sheep milk proteins as nutritional, structural, functional, and industrial. It summarizes sheep milk production, SMP composition and nutrition, and factors affecting SMP yield and quality, including breed, lactation stage, parity, genotype, season, and nutritional status. Enrichment, separation, purification, and identification strategies are critically evaluated, together with reported bioactivities and food related application potential. KEY FINDINGS AND CONCLUSIONS: SMPs are promising multifunctional ingredients for dairy innovation, infant nutrition, and bio-based food materials. Their value should not be inferred from protein abundance alone, but from the combined effects of protein composition, casein micelle structure, digestion-derived peptide release, bioaccessibility, and processing feasibility. However, translation remains constrained by inconsistent raw-material supply, compositional variation, limited structure and activity understanding, and the predominance of preclinical evidence. Future studies should prioritize ACE-inhibitory and DPP-IV-inhibitory sheep milk peptides by validating their structure activity relationships, bioavailability, and in vivo mechanisms in relevant cardiometabolic models. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Wen, Qinghua AU - Wen Q AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Liu, Xiaorui AU - Liu X AD - Division of Laboratory Safety and Services, Northwest A&F University, Yangling, Shaanxi 712100, China. FAU - Sun, Lei AU - Sun L AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Jiang, Yue AU - Jiang Y AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Liu, Jiaxin AU - Liu J AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Kraithong, Supaluck AU - Kraithong S AD - Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China. FAU - Ahmad, Naseer AU - Ahmad N AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Song, Yuxuan AU - Song Y AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. Electronic address: xuyuan_song2016@163.com. FAU - Zhang, Lei AU - Zhang L AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. Electronic address: zhanglei07dongke@163.com. LA - eng PT - Journal Article PT - Review DEP - 20260810 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 RN - 0 (Bioactive Peptides, Dietary) RN - 0 (Caseins) RN - 0 (Milk Proteins) SB - IM MH - Animals MH - Humans MH - Bioactive Peptides, Dietary MH - Caseins/analysis MH - Lactation MH - *Milk/chemistry MH - *Milk Proteins/chemistry/analysis MH - *Nutritive Value MH - Sheep OTO - NOTNLM OT - Bioactivity OT - Dairy innovation OT - Functional ingredients OT - Separation technologies OT - Sheep milk proteins COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/07 23:34 MHDA- 2026/09/07 23:35 CRDT- 2026/09/07 20:53 PHST- 2026/05/11 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/01 00:00 [accepted] PHST- 2026/09/07 23:35 [medline] PHST- 2026/09/07 23:34 [pubmed] PHST- 2026/09/07 20:53 [entrez] AID - S0963-9969(26)01934-4 [pii] AID - 10.1016/j.foodres.2026.120247 [doi] PST - ppublish SO - Food Res Int. 2026 Nov 1;243(Pt 2):120247. doi: 10.1016/j.foodres.2026.120247. Epub 2026 Aug 10. PMID- 42704402 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260910 IS - 2196-1042 (Electronic) IS - 1723-7785 (Print) IS - 1723-7785 (Linking) VI - 27 IP - 1 DP - 2026 Sep 7 TI - Morphological variations and differences of the mandible and midfacial skeleton across different sagittal skeletal patterns and sexes: a three-dimensional geometric morphometric analysis. LID - 10.1186/s40510-026-00645-y [doi] LID - 39 AB - BACKGROUND: Maxillofacial morphological analysis is essential for orthodontic diagnosis, treatment planning, and outcome evaluation. However, previous two-dimensional or landmark-based studies can hardly comprehensively analyze three-dimensional morphology. Therefore, this study aimed to analyze morphological variations and differences of the mandible and midfacial skeleton across different sagittal skeletal patterns and sexes using three-dimensional geometric morphometrics, while also providing novel perspectives and methodologies for morphological analysis in orthodontics. METHODS: The midfacial skeleton and mandible were analyzed separately. Three-dimensional dense templates were first constructed and template registration was validated. Through template registration, all segmented skeleton images (n = 186) obtained a homologous configuration with tens of thousands of quasi-landmarks. After generalized Procrustes analysis, principal component analysis (PCA) was conducted to examine shape variations. The average skeletal shapes were calculated and compared according to sagittal skeletal pattern and sex. Partial least squares regression (PLSR) was used to evaluate the independent effects of ANB angle and sex on skeletal shape. RESULTS: PCA revealed the principal patterns of shape variations. The first principal component (PC1) of the mandible primarily showed variation in sagittal length and inter-ramal width (explaining 31.80% of the total variance), whereas PC1 of the midfacial skeleton mainly showed variation in vertical height and inter-zygomatic width (24.07%). Morphological differences were demonstrated through comparisons of average skeletal shapes grouped by sagittal skeletal pattern or sex. PLSR indicated significant effects of ANB angle and sex on the three-dimensional morphology of both the mandible and midfacial skeleton (all P < 0.001). Specifically, with increasing ANB angle (skeletal Class II tendency), the length of the condyle (condylar head and neck) decreased, the antegonial notch became more prominent, and the maxillary alveolar bone plane rotated downward and backward (clockwise). Compared with females, males exhibited a more prominent mandibular angle, increased inter-zygomatic width, and more protrusive nasal bridge and anterior nasal spine. CONCLUSIONS: Three-dimensional dense geometric morphometrics enables a more comprehensive analysis of facial skeletal morphology. Three-dimensional morphological variations and differences of the mandible and midfacial skeleton across different sagittal skeletal patterns and sexes were characterized. CI - (c) 2026. The Author(s). FAU - Zhao, Guangpu AU - Zhao G AD - Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. FAU - Su, Xinyu AU - Su X AD - Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. FAU - He, Danqing AU - He D AD - Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. hedanqing@bjmu.edu.cn. FAU - Gu, Yan AU - Gu Y AUID- ORCID: 0000-0003-0108-4325 AD - Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. guyan96@126.com. LA - eng GR - L242130/Natural Science Foundation of Beijing Municipality/ GR - 7232217/Natural Science Foundation of Beijing Municipality/ GR - 82170996/National Natural Science Foundation of China/ GR - PKUSSNCT-25A04/Program for New Clinical Techniques and Therapies of Peking University School and Hospital of Stomatology/ PT - Journal Article DEP - 20260907 PL - Germany TA - Prog Orthod JT - Progress in orthodontics JID - 100936353 SB - IM MH - Humans MH - Female MH - *Mandible/anatomy & histology/diagnostic imaging MH - Male MH - *Imaging, Three-Dimensional/methods MH - Principal Component Analysis MH - *Facial Bones/anatomy & histology/diagnostic imaging MH - Cephalometry/methods MH - Sex Factors MH - Anatomic Landmarks MH - Sex Characteristics MH - Adolescent PMC - PMC13550393 OTO - NOTNLM OT - Geometric morphometrics OT - Mandible OT - Midfacial skeleton OT - Morphology OT - Sagittal skeletal pattern OT - Sex characteristics OT - Three-dimensional COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Biomedical Ethics Committee of Peking University School and Hospital of Stomatology (PKUSSIRB-202497034). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/07 17:36 MHDA- 2026/09/07 17:37 PMCR- 2026/09/07 CRDT- 2026/09/07 11:05 PHST- 2025/12/08 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/07 17:37 [medline] PHST- 2026/09/07 17:36 [pubmed] PHST- 2026/09/07 11:05 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.1186/s40510-026-00645-y [pii] AID - 645 [pii] AID - 10.1186/s40510-026-00645-y [doi] PST - epublish SO - Prog Orthod. 2026 Sep 7;27(1):39. doi: 10.1186/s40510-026-00645-y. PMID- 42703816 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260907 LR - 20260912 IS - 1308-8734 (Print) IS - 1308-8742 (Electronic) IS - 1308-8734 (Linking) VI - 58 IP - 4 DP - 2026 Aug 20 TI - Association of Early and Late Postnatal Serum Lactate/Albumin Ratio and Retinopathy of Prematurity in Preterm Infants: A 2 Time Point Comparative Study. PG - 1-6 LID - 10.5152/eurasianjmed.2026.261457 [doi] LID - e261457 AB - BACKGROUND: One easily accessible compound index that shows the metabolic and inflammatory status of critically ill patients is the lactate-albumin ratio (LAR). This study set out to evaluate the connection between LAR and retinopathy of prematurity (ROP) in premature infants. METHODS: The investigation was conducted retrospectively on 150 premature infants born before 34 weeks who underwent screening for ROP in the neonatal intensive care unit. Demographic and clinical data, as well as ROP examination findings, were recorded for all participants. For the first 24 h following delivery (early phase) and at 34-36 weeks' postmenstrual age (late period), serum lactate and albumin values were measured separately. For each of these measurements, the lactate/albumin ratio was calculated. Mann-Whitney U-test, logistic regression, correlation analyses, together with receiver operating characteristic (ROC) analysis were performed. RESULTS: In infants who developed ROP, both the LAR calculated in the early phase (1.16 +/- 0.56, P = .03) and the LAR calculated in the late period (0.53 +/- 0.19, P = .02) were found to be significantly higher than those without ROP. In post hoc analyses based on disease severity, LAR values were significantly higher in the treatment-requiring ROP group (P = .02). In logistic regression, late-period LAR showed a borderline but statistically non-significant association with ROP development (OR = 11.05; 95% CI = 0.97-125.9; P = .053). CONCLUSION: Lactate-albumin ratio values were associated with ROP development and disease severity in premature infants. However, LAR was not demonstrated to be an independent predictor of ROP in the present study. As a composite index reflecting nutrition, inflammation, tissue oxygenation, and metabolic stress, LAR may provide complementary information regarding systemic vulnerability in premature infants rather than serving as a standalone predictive or screening biomarker. Further prospective and multicenter studies are needed to clarify its potential role in ROP risk assessment. Cite this article as: Caliskan B, Korkut D, Kara M, Tekgunduz KS. Association of early and late postnatal serum lactate/albumin ratio and retinopathy of prematurity in preterm infants: a 2 time point comparative study. Eurasian J Med. 2026, 58(4), 1457, doi: 10.5152/eurasianjmed.2026.261457. FAU - Caliskan, Busra AU - Caliskan B AUID- ORCID: 0000-0002-2350-184X AD - Department of Ophthalmology, Ataturk University Faculty of Medicine, Erzurum, Turkiye. FAU - Korkut, Dilara AU - Korkut D AUID- ORCID: 0009-0004-2163-4122 AD - Department of Neonatology, Ataturk University Faculty of Medicine,Erzurum, Turkiye. FAU - Kara, Mustafa AU - Kara M AUID- ORCID: 0000-0001-6568-1538 AD - Department of Neonatology, Ataturk University Faculty of Medicine,Erzurum, Turkiye. FAU - Tekgunduz, Kadir Serafettin AU - Tekgunduz KS AUID- ORCID: 0000-0001-6375-5644 AD - Department of Neonatology, Ataturk University Faculty of Medicine,Erzurum, Turkiye. LA - eng PT - Journal Article DEP - 20260820 PL - Turkey TA - Eurasian J Med JT - The Eurasian journal of medicine JID - 101557701 PMC - PMC13559898 OTO - NOTNLM OT - Albumin OT - biomarker OT - lactate OT - retinopathy of prematurity OT - the lactate-albumin ratio COIS- Declaration of Interests: The authors have no conflicts of interest to declare. EDAT- 2026/09/07 11:37 MHDA- 2026/09/07 11:38 PMCR- 2026/08/20 CRDT- 2026/09/07 05:44 PHST- 2026/08/20 00:00 [received] PHST- 2026/09/07 11:38 [medline] PHST- 2026/09/07 11:37 [pubmed] PHST- 2026/09/07 05:44 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - eajm-58-4-261457 [pii] AID - 10.5152/eurasianjmed.2026.261457 [doi] PST - epublish SO - Eurasian J Med. 2026 Aug 20;58(4):1-6. doi: 10.5152/eurasianjmed.2026.261457. PMID- 42703626 OWN - NLM STAT- Publisher LR - 20260910 IS - 1941-0921 (Electronic) IS - 1941-7381 (Print) IS - 1941-0921 (Linking) DP - 2026 Sep 7 TI - Feasibility and Clinical Utility of a Modified Step Test for Evaluating Exercise Intolerance After Pediatric and Adolescent Concussion in the Ambulatory Setting. PG - 19417381261477255 LID - 10.1177/19417381261477255 [doi] LID - 19417381261477255 AB - BACKGROUND: Exercise intolerance (EI) is an important component of concussion pathophysiology, serving as a predictor for persisting symptoms, as well as a therapeutic target. It traditionally requires bulky, expensive equipment such as a treadmill to assess. PURPOSE: To evaluate the feasibility of a modified step test to assess EI in youth with concussion and determine its clinical utility for predicting prolonged recovery. STUDY DESIGN: Observational. LEVEL OF EVIDENCE: Level 2. METHODS: A modified step test - an aerobic challenge of 3 to 6 minutes of stepping, targeting zone 2 heartrate (HR, defined as 60% to 70% of maximum HR for age) - assessed patients aged 8 to 18 years with concussion presenting to our concussion specialty program within /=3 concussion symptoms from baseline, or patient/parent request to stop), or (2) minor: symptom provocation but below early stopping criteria threshold. Multivariate modeling (1) assessed the odds of EI adjusting for relevant covariates, and (2) determined the influence of EI on prolonged recovery (time in clinical care >28 days), adjusting for factors with known associations with prolonged recovery. RESULTS: We included 578 patients. Overall, 366 patients (63%) met criteria for EI, with EI prevalence varying by sex, history of anxiety or depression, and initial symptom burden. In the fully adjusted model, female sex (odds ratio [OR], 1.9; 95% CI, 1.3-2.8), and initial visit symptom burden (OR, 1.05; 95% CI, 1.04-1.06) were associated with EI. Thirty percent of patients (n = 174) demonstrated prolonged recovery. In the multivariate model, major (OR, 1.8; 95% CI, 1.1-3.1) and minor (OR, 2.4; 95% CI, 1.4-4.1) EI were both associated with prolonged recovery. CONCLUSION: This study demonstrates feasibility of identifying EI in youth with concussion via a simple in-office modified step test and the relationship of this measure to prolonged recovery. CLINICAL RELEVANCE: These results have clinical utility for individualizing concussion recovery plans in ambulatory care outside of specialty care settings. FAU - Grady, Matthew F AU - Grady MF AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, and Sports Medicine and Performance Center, Division of Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Fedonni, Daniele AU - Fedonni D AD - Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Wilkes, James AU - Wilkes J AUID- ORCID: 0000-0003-3402-7650 AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Cobb, Justin AU - Cobb J AD - Sports Medicine and Performance Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Calandra, Lindsey AU - Calandra L AD - Sports Medicine and Performance Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Easby, Kate AU - Easby K AD - Sports Medicine and Performance Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Corwin, Daniel J AU - Corwin DJ AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, and Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Master, Christina L AU - Master CL AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, and Sports Medicine and Performance Center, Division of Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Arbogast, Kristy B AU - Arbogast KB AUID- ORCID: 0000-0002-1694-4562 AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, and Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. LA - eng PT - Journal Article DEP - 20260907 PL - United States TA - Sports Health JT - Sports health JID - 101518422 SB - IM PMC - PMC13550243 OTO - NOTNLM OT - concussion OT - exercise OT - office assessment OT - pediatric EDAT- 2026/09/07 05:35 MHDA- 2026/09/07 05:35 PMCR- 2027/09/07 CRDT- 2026/09/07 04:26 PHST- 2026/09/07 05:35 [medline] PHST- 2026/09/07 05:35 [pubmed] PHST- 2026/09/07 04:26 [entrez] PHST- 2027/09/07 00:00 [pmc-release] AID - 10.1177_19417381261477255 [pii] AID - 10.1177/19417381261477255 [doi] PST - aheadofprint SO - Sports Health. 2026 Sep 7:19417381261477255. doi: 10.1177/19417381261477255. PMID- 42703382 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260908 IS - 1177-8881 (Electronic) IS - 1177-8881 (Linking) VI - 20 DP - 2026 TI - A Physiologically-Based Pharmacokinetic Model to Predict Posaconazole Suspension Exposure and Optimize Dosing Strategy in Pediatric Hematology Patients: Incorporating the Impact of Food Intake. PG - 632843 LID - 10.2147/DDDT.S632843 [doi] LID - 632843 AB - OBJECTIVE: This study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model for posaconazole oral suspension in pediatric hematology patients to predict systemic exposure and optimize dose regimens that incorporate food intake. METHODS: A PBPK model was established and validated in adults. The model was then extrapolated to pediatric patients by integrating age-specific physiological parameters. The pediatric model was validated using published data and local therapeutic drug monitoring results. The validated model was employed to simulate posaconazole exposure across different age groups, dosing regimens, and meal conditions. RESULTS: The adult PBPK model showed good predictability, with fold errors within 0.5-2.0 and a geometric mean fold error < 2.0. Sensitivity analysis identified the bile salt solubilization ratio, gastric pH, and hepatic UGT1A4 as critical determinants. The pediatric model accurately predicted plasma concentrations, with a mean absolute prediction error of 12.3%. Simulations revealed that achieving prophylactic trough concentration (C(min)) is challenging under fasted conditions, while fed administration significantly increases C(min)s. C(min)s increased with age and meal fat/calorie content, but no significant further increase was observed across all age groups beyond 6 mg/kg dose levels under fed conditions, with this plateau pattern consistent for both three- and four-times daily regimens. The oral suspension was unreliable in children aged < 2 years. In contrast, a high-fat, high-calorie meal was necessary for children aged 2-6 years, and a moderate-fat, moderate-calorie meal for those aged 7-12 years, whereas a low-fat, low-calorie meal was sufficient for those aged >/= 13 years. CONCLUSION: This study successfully developed and validated a PBPK model for posaconazole suspension in pediatric hematology patients, which could serve as a supportive in silico tool for model-informed dose optimization in this population. Further prospective clinical validation is still required to support its real-world dosing decision application. CI - (c) 2026 Wu et al. FAU - Wu, Juan AU - Wu J AUID- ORCID: 0000-0002-0792-5300 AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Qin, Xia AU - Qin X AD - Blood and Marrow Transplantation Center, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Huang, Xiaohang AU - Huang X AUID- ORCID: 0009-0000-3530-3835 AD - Blood and Marrow Transplantation Center, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Wang, Dengyu AU - Wang D AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Jin, Cheng AU - Jin C AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Huang, Shiying AU - Huang S AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Li, Zhuo AU - Li Z AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Liu, Manman AU - Liu M AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. LA - eng PT - Journal Article DEP - 20260902 PL - New Zealand TA - Drug Des Devel Ther JT - Drug design, development and therapy JID - 101475745 RN - 0 (Triazoles) RN - 6TK1G07BHZ (posaconazole) RN - 0 (Suspensions) RN - 0 (Antifungal Agents) SB - IM MH - Humans MH - *Triazoles/pharmacokinetics/administration & dosage/blood MH - Child MH - *Models, Biological MH - Suspensions MH - Child, Preschool MH - Administration, Oral MH - Dose-Response Relationship, Drug MH - *Antifungal Agents/pharmacokinetics/administration & dosage MH - Adolescent MH - *Eating MH - Infant MH - Male MH - Female PMC - PMC13546638 OTO - NOTNLM OT - dose optimization OT - food intake OT - pediatrics OT - physiologically based pharmacokinetic model OT - posaconazole oral suspension COIS- The authors have no conflicts of interest to declare regarding the content of this article. EDAT- 2026/09/07 05:35 MHDA- 2026/09/07 05:36 PMCR- 2026/09/02 CRDT- 2026/09/07 04:02 PHST- 2026/06/14 00:00 [received] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/07 05:36 [medline] PHST- 2026/09/07 05:35 [pubmed] PHST- 2026/09/07 04:02 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 632843 [pii] AID - 10.2147/DDDT.S632843 [doi] PST - epublish SO - Drug Des Devel Ther. 2026 Sep 2;20:632843. doi: 10.2147/DDDT.S632843. eCollection 2026. PMID- 42701327 OWN - NLM STAT- Publisher LR - 20260906 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Sep 6 TI - Bringing the child's and parents' voices together: French validation of the SMU and STU quality of life questionnaires in pediatric obesity. PG - 2601060261484279 LID - 10.1177/02601060261484279 [doi] AB - BackgroundChildhood obesity is associated with significant impairments in health-related quality of life (HRQoL), yet culturally adapted, weight-specific tools are lacking in French-speaking settings.AimThis study aimed to validate French versions of the Sizing Me Up (SMU) and Sizing Them Up (STU) questionnaires to assess obesity-related quality of life in children and adolescents from self- and parent-report perspectives.MethodsShortened French versions of the SMU and STU were developed, retaining three subscales common to both instruments (Emotional, Physical, and Teasing/Marginalization) based on theoretical and psychometric criteria. A clinical sample included 120 children and adolescents with obesity (aged 5-18 years) and their parents. Psychometric analyses included internal consistency, confirmatory factor analysis, convergent validity with the Pediatric Quality of Life Inventory (PedsQL), sensitivity to body mass index (BMI) z-scores, measurement invariance across age and sex, and parent-child agreement.ResultsBoth instruments demonstrated good internal consistency and a stable three-factor structure. Associations were observed between the BMI z-score and the Physical domain, with modest effect sizes comparable to those of the generic PedsQL. Convergent validity was supported by correlations with corresponding PedsQL subscales. Measurement invariance held across age groups and for the SMU across sex, but the STU across sex did not achieve configural invariance. Procrustean analysis indicated moderate structural similarities between child and parent profiles, with moderate to good individual-level agreement, higher for physical than emotional domains.SummaryThe shortened French SMU and STU are reliable and valid tools for assessing HRQoL in pediatric obesity, supporting their use in clinical and research settings. FAU - Brodard, Fabrice AU - Brodard F AUID- ORCID: 0000-0002-3000-0891 AD - Family and Development Research Center, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 AD - Institute of Psychology, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 FAU - Antonietti, Jean-Philippe AU - Antonietti JP AUID- ORCID: 0000-0003-0117-4769 AD - Family and Development Research Center, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 FAU - Amouroux, Remy AU - Amouroux R AUID- ORCID: 0000-0003-3402-0942 AD - Family and Development Research Center, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 FAU - Bouthors, Therese AU - Bouthors T AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 FAU - Hauschild, Michael AU - Hauschild M AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 FAU - Ruiz Arana, Inge Lore AU - Ruiz Arana IL AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 FAU - Antoniou, Maria-Christina AU - Antoniou MC AUID- ORCID: 0000-0002-8089-7908 AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 LA - eng PT - Journal Article DEP - 20260906 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - French translation OT - Pediatric obesity OT - SMU OT - STU OT - quality of life OT - questionnaire validation EDAT- 2026/09/06 05:40 MHDA- 2026/09/06 05:40 CRDT- 2026/09/06 03:23 PHST- 2026/09/06 05:40 [medline] PHST- 2026/09/06 05:40 [pubmed] PHST- 2026/09/06 03:23 [entrez] AID - 10.1177/02601060261484279 [doi] PST - aheadofprint SO - Nutr Health. 2026 Sep 6:2601060261484279. doi: 10.1177/02601060261484279. PMID- 42700347 OWN - NLM STAT- MEDLINE DCOM- 20260905 LR - 20260908 IS - 2162-4968 (Electronic) IS - 2162-4968 (Linking) VI - 15 IP - 1 DP - 2026 Sep 5 TI - Obesity and Iron Metabolism: Mechanisms, Status Assessment, and Clinical Implications. LID - 10.1007/s13679-026-00753-0 [doi] LID - 76 AB - PURPOSE OF REVIEW: Obesity reshapes systemic iron handling, yet the resulting iron phenotype is frequently misclassified at the bedside and in population studies. This review examines how excess adiposity disturbs iron metabolism and complicates iron-status assessment, with balanced attention to biology and measurement problems across adults and children. RECENT FINDINGS: Adipose tissue is an endocrine, inflammatory, and iron-handling organ. In obesity, interleukin-6 drives hepatic hepcidin through JAK/STAT3 signaling, while leptin, adipose hypoxia, and adipose hepcidin expression may contribute additional signals. Hepcidin degrades ferroportin, reducing duodenal iron export and limiting macrophage iron release, producing hypoferremia and iron-restricted erythropoiesis despite normal or elevated ferritin. We and others have shown that women with obesity may have higher hepcidin, ferritin, and inflammatory markers but lower serum iron. Stable-isotope and intervention studies suggest weight loss reduces inflammation and hepcidin and improves iron absorption, whereas the World Health Organization and Biomarkers of Nutrition for Development frameworks recommend interpreting ferritin relative to inflammation. Iron status in obesity spans a continuum from absolute or functional iron deficiency to sufficiency and, in some individuals, hyperferritinemia with possible dysmetabolic iron overload. Reliable assessment requires a multi-marker strategy: ferritin interpreted alongside an inflammation marker such as C-reactive protein and supported by transferrin saturation, soluble transferrin receptor, reticulocyte hemoglobin, or other context-appropriate indices. Management should address reversible inflammation through weight loss and metabolic risk reduction, use oral or intravenous iron according to the likelihood of true deficiency and hepcidin-mediated oral refractoriness, and avoid reflexive phlebotomy for dysmetabolic hyperferritinemia without confirmed overload. CI - (c) 2026. The Author(s). FAU - Aguree, Sixtus AU - Aguree S AD - Department of Applied Health Science, School of Public Health- Bloomington, Indiana University, Bloomington, IN, 47405, USA. saguree@iu.edu. FAU - Meng, Xiangqi AU - Meng X AD - Department of Applied Health Science, School of Public Health- Bloomington, Indiana University, Bloomington, IN, 47405, USA. LA - eng PT - Journal Article PT - Review DEP - 20260905 PL - United States TA - Curr Obes Rep JT - Current obesity reports JID - 101578283 RN - E1UOL152H7 (Iron) RN - 0 (Hepcidins) RN - 0 (Biomarkers) RN - 9007-73-2 (Ferritins) SB - IM MH - Humans MH - *Obesity/metabolism/complications/physiopathology MH - *Iron/metabolism MH - Hepcidins/metabolism MH - Biomarkers/blood MH - Ferritins/blood/metabolism MH - Adipose Tissue/metabolism MH - Female MH - Inflammation/metabolism PMC - PMC13546355 OTO - NOTNLM OT - Hepcidin OT - Inflammation OT - Iron deficiency OT - Iron status assessment OT - Obesity OT - Serum ferritin COIS- Declarations. This article does not contain any studies with human participants or animals performed by any of the authors. Use of Generative AI: The author(s) declare that no generative AI or AI-assisted technology was used in the writing of this manuscript. Competing interests: The authors declare no competing interests. EDAT- 2026/09/06 01:18 MHDA- 2026/09/06 01:19 PMCR- 2026/09/05 CRDT- 2026/09/05 13:07 PHST- 2026/07/02 00:00 [received] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/06 01:19 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 13:07 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - 10.1007/s13679-026-00753-0 [pii] AID - 753 [pii] AID - 10.1007/s13679-026-00753-0 [doi] PST - epublish SO - Curr Obes Rep. 2026 Sep 5;15(1):76. doi: 10.1007/s13679-026-00753-0. PMID- 42700321 OWN - NLM STAT- MEDLINE DCOM- 20260905 LR - 20260908 IS - 1539-0829 (Electronic) IS - 1534-4827 (Print) IS - 1534-4827 (Linking) VI - 26 IP - 1 DP - 2026 Sep 5 TI - The Hidden Everyday-Life Burden of Pediatric Type 1 Diabetes: A Household Implementation Framework for Modern Diabetes Technology and Family Care. LID - 10.1007/s11892-026-01643-4 [doi] LID - 26 AB - PURPOSE OF REVIEW: Frameworks that classify the financial burdens of managing pediatric type 1 diabetes (T1D) primarily focus on measurable material hardship, affordability, and cost-related distress and therefore do not sufficiently detail the household-level resources that care requires from families. This study is a conceptual narrative review that aims to integrate the missing elements into a new three-level burden model, thereby linking the costs visible in clinical care, the household implementation burden borne by families, and the lived everyday experience of the child-parent-family triad. The proposed contribution of the model is to interpret the sustainability of modern T1D care not exclusively in terms of technology access, reimbursement, or clinical effectiveness, but also as a function of families' temporal, digital, organizational, and decision-making capacity in relation to everyday self-management, educational-setting coordination, caregiver time investment, digital health literacy, and the digital divide. RECENT FINDINGS: The literature documents direct healthcare costs, out-of-pocket expenses, informal care, dietary adaptation, technology-related costs, parental distress, and time burden well when considered separately. However, these elements often do not appear as an integrated, cumulative household implementation burden. In pediatric T1D, the actual usability and sustainability of technology depend not only on device availability and reimbursement but also on the family's organizational, digital, temporal, and decision-making capacity. The T1D-ELB-P framework interprets the burdens placed on families as an organizing principle: it does not merely list domains but shows how financial, digital, temporal, decision-making, and institutional requirements can accumulate as household implementation burdens. The proposed Type 1 Diabetes Everyday-Life Burden-Pediatric framework (T1D-ELB-P) conceptualizes the everyday-life economic burden of pediatric type 1 diabetes as a complementary dimension interpretable at the household and caregiver levels. It highlights five interrelated domains: lifestyle and dietary adaptation; non-reimbursed or partially reimbursed consumables and accessories; digital infrastructure and digital health literacy; time, attention, and decision burden; and educational, extracurricular, and workplace coordination. In this model, technology is not a separate focus but a cross-cutting factor that makes the implementation work borne by families visible across several domains. The clinical and health-policy significance of the framework lies in its highlighting of how the real-world use of modern T1D care is embedded in the everyday functioning of the child-parent-family triad. Future cost-of-illness, health technology assessment, and patient-centered studies would benefit from explicitly measuring family implementation costs and capacities. CI - (c) 2026. The Author(s). FAU - Tesch, Zsanett AU - Tesch Z AD - Department of Health Economics, Albert Szent-Gyorgyi Medical School, University of Szeged, 35. Kossuth L. sgt., Szeged, H-6724, Hungary. FAU - Buzas, Norbert AU - Buzas N AUID- ORCID: 0000-0002-4496-8828 AD - Department of Health Economics, Albert Szent-Gyorgyi Medical School, University of Szeged, 35. Kossuth L. sgt., Szeged, H-6724, Hungary. buzas.norbert@med.u-szeged.hu. AD - Department of Theoretical Health Sciences and Health Management, Faculty of Health Sciences and Social Studies, University of Szeged, Szeged, Hungary. buzas.norbert@med.u-szeged.hu. LA - eng PT - Journal Article PT - Review DEP - 20260905 PL - United States TA - Curr Diab Rep JT - Current diabetes reports JID - 101093791 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/economics/therapy/psychology MH - *Cost of Illness MH - Child MH - Digital Health MH - Caregivers MH - Health Care Costs PMC - PMC13546161 OTO - NOTNLM OT - Diabetes technology OT - Digital health literacy OT - Digital infrastructure OT - Household implementation burden OT - Parental burden OT - Pediatric type 1 diabetes OT - School diabetes care COIS- Declarations. Human/Animal Studies: This article does not contain any studies with human or animal subjects performed by any of the authors. Competing Interests: The authors declare no competing interests. EDAT- 2026/09/06 01:18 MHDA- 2026/09/06 01:19 PMCR- 2026/09/05 CRDT- 2026/09/05 13:05 PHST- 2026/06/19 00:00 [received] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/09/06 01:19 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 13:05 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - 10.1007/s11892-026-01643-4 [pii] AID - 1643 [pii] AID - 10.1007/s11892-026-01643-4 [doi] PST - epublish SO - Curr Diab Rep. 2026 Sep 5;26(1):26. doi: 10.1007/s11892-026-01643-4. PMID- 42699435 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260905 LR - 20260907 IS - 2229-516X (Print) IS - 2248-9606 (Electronic) IS - 2229-516X (Linking) VI - 16 IP - 3 DP - 2026 Jul-Sep TI - Cardiometabolic Risk Clustering and Surrogate Markers of Insulin Resistance in Adolescents. PG - 171-178 LID - 10.4103/ijabmr.ijabmr_115_26 [doi] AB - BACKGROUND: Adolescent obesity is increasingly linked to early insulin resistance (IR) and clustering of cardiometabolic abnormalities, including impaired glucose regulation, dyslipidemia, inflammation, and liver dysfunction. Identifying at-risk adolescents remains challenging due to physiological variability and a lack of standardized definitions. AIM: The aim of this study was to identify simple and reliable surrogate markers of IR and associated cardiometabolic risk in overweight and obese adolescents. MATERIALS AND METHODS: In this cross-sectional study, 182 adolescents aged 10-19 years underwent detailed anthropometric, clinical, and biochemical evaluation, including fasting glucose, insulin, lipid profile, alanine aminotransferase (ALT), uric acid, and high-sensitivity C-reactive protein (hs-CRP). IR was defined as homeostatic model assessment of IR (HOMA-IR) >/=2.5, and associations with demographic, anthropometric, lifestyle, dietary, clinical, and metabolic factors were analyzed. RESULTS: IR was identified in 62.6% of participants and was more common among obese and pubertal adolescents. Central obesity was present not only in the overweight and obese groups but also in 11.2% of normal-weight adolescents, indicating metabolic risk beyond body mass index (BMI). Measures of central adiposity, particularly waist-to-height ratio (WHtR), showed stronger associations with IR than BMI. IR-positive adolescents demonstrated clustering of metabolic, inflammatory, and hepatic abnormalities, including elevated glucose, insulin, triglycerides, triglyceride: high-density lipoprotein cholesterol (TG: HDL-C) ratio, hs-CRP, uric acid, and ALT, with reduced HDL-C. Acanthosis nigricans, low physical activity, poor sleep, and increased screen time were also more frequent. Metabolic syndrome was present in 13.18% of participants. CONCLUSION: IR and cardiometabolic risk are highly prevalent in adolescents with obesity. WHtR, TG: HDL-C ratio, ALT, hs-CRP, and acanthosis nigricans may serve as practical surrogate markers for identifying adolescents with HOMA-IR-defined IR and supporting early preventive strategies. CI - Copyright: (c) 2026 International Journal of Applied and Basic Medical Research. FAU - Chhabra, Namrata AU - Chhabra N AD - Department of Biochemistry, Cell Biology, and Genetics, American University of Antigua College of Medicine, Coolidge, Antigua and Barbuda, USA. FAU - Chhabra, Sarah AU - Chhabra S AD - Department of Diabetes and Endocrinology, University of Virginia, Charlottesville, VA, USA. FAU - Patil, Ranjit AU - Patil R AD - Department of Biochemistry, S. S. R. Medical College, Phoenix, University of Mauritius, Mauritius, Punjab, India. FAU - Kukreja, Sahiba AU - Kukreja S AD - Department of Biochemistry, Sri Guru Ram Das University of Health Sciences, Amritsar, Punjab, India. LA - eng PT - Journal Article DEP - 20260819 PL - India TA - Int J Appl Basic Med Res JT - International journal of applied & basic medical research JID - 101579831 PMC - PMC13544660 OTO - NOTNLM OT - Acanthosis nigricans OT - adolescent obesity OT - cardiometabolic risk OT - central adiposity OT - insulin resistance OT - metabolic syndrome OT - triglyceride-high-density lipoprotein cholesterol ratio COIS- There are no conflicts of interest. EDAT- 2026/09/06 01:18 MHDA- 2026/09/06 01:19 PMCR- 2026/07/01 CRDT- 2026/09/05 10:08 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/06 01:19 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 10:08 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - IJABMR-16-171 [pii] AID - 10.4103/ijabmr.ijabmr_115_26 [doi] PST - ppublish SO - Int J Appl Basic Med Res. 2026 Jul-Sep;16(3):171-178. doi: 10.4103/ijabmr.ijabmr_115_26. Epub 2026 Aug 19. PMID- 42699094 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260905 LR - 20260907 IS - 2950-1334 (Electronic) IS - 2950-1334 (Linking) VI - 14 DP - 2026 Nov TI - Multimodality assessment of right ventricular-pulmonary arterial coupling and pulmonary artery compliance in youth with pulmonary arterial hypertension: A pilot study. PG - 100664 LID - 10.1016/j.jhlto.2026.100664 [doi] LID - 100664 AB - BACKGROUND: Cardiac magnetic resonance (CMR) enables comprehensive assessment of right ventricular (RV) function and ventricular-vascular interaction in pulmonary arterial hypertension (PAH). This exploratory pilot study compared echocardiographic and CMR-derived surrogate indices of RV-pulmonary arterial (RV-PA) coupling and examined indexed pulmonary artery compliance (PAc) in adolescents and young adults with PAH. METHODS: Twenty adolescents and young adults with Group 1 PAH underwent transthoracic echocardiography, CMR, and cardiac catheterization within 7 days. Echocardiographic TAPSE/systolic pulmonary artery pressure (sPAP) and CMR RV stroke volume/end-systolic volume were analyzed as noninvasive surrogates of RV-PA coupling; pressure-volume loop-derived end-systolic elastance/arterial elastance was not measured. Indexed PAc and pulmonary vascular resistance index (PVRi) were derived from catheterization and CMR data. Associations with WHO functional class, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and 6-minute walk distance (6MWD) were explored. RESULTS: Echocardiographic TAPSE/sPAP showed limited associations with clinical severity measures. CMR-derived RV indices showed stronger exploratory associations with NT-proBNP and 6MWD. In the prespecified multivariable model of the exercise endpoint, indexed PAc had the largest standardized coefficient (beta = -0.78; 95% CI, -1.48 to -0.09; p = 0.031); PVRi and the imaging surrogates were not statistically significant. Estimates were imprecise because of the small sample. CONCLUSIONS: In this small, hypothesis-generating cohort, CMR-derived RV-PA coupling and indexed PAc provided complementary physiologic information beyond the echocardiographic surrogate. These observations require validation against pressure-volume loop-derived coupling and prospective clinical outcomes. CI - (c) 2026 The Author(s). FAU - Raj, Shashi AU - Raj S AD - Clinical Lead, Pediatric & Adult CHD Heart Failure and Transplantation, Narayana Institute of Cardiac Sciences, Bangalore, India. FAU - Khan, Basha AU - Khan B AD - Program Director, Pulmonology & Lung Transplantation, Narayana Institute of Cardiac Sciences, Bangalore, India. FAU - Raj, Vimal AU - Raj V AD - Chief, Department of Cardiothoracic Radiology, Narayana Institute of Cardiac Sciences, Bangalore, India. FAU - Pulagam, Vamsidhar Reddy AU - Pulagam VR AD - Fellow, Department of Cardiothoracic Radiology, Narayana Institute of Cardiac Sciences, Bangalore, India. FAU - Das, Bibhuti B AU - Das BB AD - Pediatric Cardiology, Methodist Children's Hospital, San Antonio, Texas. LA - eng PT - Journal Article DEP - 20260815 PL - United States TA - JHLT Open JT - JHLT open JID - 9918716187806676 PMC - PMC13543909 OTO - NOTNLM OT - cardiac magnetic resonance imaging OT - pediatric pulmonary hypertension OT - pulmonary artery compliance OT - pulmonary vascular resistance OT - right ventricular-pulmonary arterial coupling COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/06 01:18 MHDA- 2026/09/06 01:19 PMCR- 2026/08/15 CRDT- 2026/09/05 09:14 PHST- 2026/09/06 01:19 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 09:14 [entrez] PHST- 2026/08/15 00:00 [pmc-release] AID - S2950-1334(26)00185-0 [pii] AID - 100664 [pii] AID - 10.1016/j.jhlto.2026.100664 [doi] PST - epublish SO - JHLT Open. 2026 Aug 15;14:100664. doi: 10.1016/j.jhlto.2026.100664. eCollection 2026 Nov. PMID- 42699078 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260905 LR - 20260907 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Baseline CALLY index is associated with all-cause mortality in HBV-ACLF patients receiving ALSS therapy. PG - 1827310 LID - 10.3389/fmed.2026.1827310 [doi] LID - 1827310 AB - OBJECTIVE: Chronic hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) has a high mortality rate even with the use of artificial liver support systems (ALSS). Reliable prognostic biomarkers are lacking. This study investigates the association between the C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index, measured at diagnosis, and all-cause mortality in HBV-ACLF patients receiving ALSS treatment. METHODS: This single-center retrospective cohort study enrolled consecutive adult patients with HBV-ACLF who received ALSS therapy at the General Hospital of Ningxia Medical University between May 2022 and November 2025. Baseline CALLY was calculated before ALSS initiation. Restricted cubic spline analysis, Kaplan-Meier survival analysis, and Cox regression were used to evaluate the association between CALLY and all-cause mortality. Logistic regression was used to assess its associations with major complications. Time-dependent ROC curves, Brier scores, calibration curves, and decision curve analysis were applied to evaluate the predictive performance and clinical utility of CALLY alone and in combination with conventional prognostic scores. RESULTS: A total of 221 patients with HBV-ACLF were included, among whom 99 experienced all-cause mortality during follow-up. Patients with low CALLY had more severe systemic inflammation, poorer nutritional and immune status, higher proportions of hepatic encephalopathy and renal insufficiency, and more advanced disease severity than those with high CALLY. Restricted cubic spline analysis showed a significant nonlinear inverse association between baseline CALLY and all-cause mortality risk. Kaplan-Meier analysis demonstrated significantly better overall survival in the high-CALLY group than in the low-CALLY group (log-rank P < 0.0001). In Cox regression analysis, higher CALLY was consistently associated with a lower risk of all-cause mortality. Time-dependent ROC analysis showed that CALLY had good discriminative ability for predicting all-cause mortality at 3, 6, and 12 months, with AUCs of 0.822, 0.837, and 0.888, respectively. The addition of CALLY to AARC grade, Child-Pugh score, MELD score, and MELD-Na score significantly improved the AUCs of the corresponding models. Brier score, calibration curve, and decision curve analyses further supported the incremental predictive value and clinical utility of CALLY? CONCLUSION: The baseline CALLY index was inversely associated with all-cause mortality in HBV-ACLF patients receiving ALSS therapy and may enhance prognostic assessment, especially when integrated with conventional prognostic scoring systems. CI - Copyright (c) 2026 Ma, Yuan, Chen, Wang, Zhang, Ou, Jiao and Ding. FAU - Ma, Wanlong AU - Ma W AD - Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. FAU - Yuan, Jinhua AU - Yuan J AD - Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. AD - Ningxia Medical University, Yinchuan, Ningxia, China. FAU - Chen, QiuYan AU - Chen Q AD - Ningxia Medical University, Yinchuan, Ningxia, China. FAU - Wang, Xia AU - Wang X AD - Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. AD - Ningxia Medical University, Yinchuan, Ningxia, China. FAU - Zhang, Le AU - Zhang L AD - Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. AD - Ningxia Medical University, Yinchuan, Ningxia, China. FAU - Ou, Yanghua AU - Ou Y AD - Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. FAU - Jiao, Yun AU - Jiao Y AD - Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. FAU - Ding, XiangChun AU - Ding X AD - Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. AD - Infectious Disease Clinical Research Center of Ningxia, Yinchuan, Ningxia, China. LA - eng PT - Journal Article DEP - 20260821 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13542649 OTO - NOTNLM OT - CALLY index OT - HBV OT - acute-on-chronic liver failure OT - artificial liver support system OT - mortality COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/06 01:18 MHDA- 2026/09/06 01:19 PMCR- 2026/08/21 CRDT- 2026/09/05 09:13 PHST- 2026/03/10 00:00 [received] PHST- 2026/07/05 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/06 01:19 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 09:13 [entrez] PHST- 2026/08/21 00:00 [pmc-release] AID - 10.3389/fmed.2026.1827310 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Aug 21;13:1827310. doi: 10.3389/fmed.2026.1827310. eCollection 2026. PMID- 42699031 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260905 LR - 20260907 IS - 2645-4904 (Electronic) IS - 2645-4904 (Linking) VI - 14 IP - 1 DP - 2026 TI - Shock-Stratified Prognostic Performance of Lactate and Procalcitonin in Pediatric Sepsis In-Hospital Mortality; A Retrospective Cohort Study. PG - e34 LID - 10.22037/aaem.v14i1.3029 [doi] LID - e34 AB - INTRODUCTION: Admission lactate and procalcitonin (PCT) are routinely measured in pediatric sepsis; however, their prognostic performance may vary by clinical phenotype. This study aimed to evaluate the shock-stratified prognostic performance of admission lactate and PCT for predicting in-hospital mortality in children with sepsis. METHODS: In this retrospective cohort study (July 2022 - July 2025), children aged 2 months to 15 years evaluated for suspected sepsis were screened; 193 met eligibility criteria and were included in analyses. Septic shock was recorded at admission, and organ dysfunction was recorded at admission or within the first 24 hours. The Phoenix Sepsis Score was calculated in 143 patients with complete lactate and other required data, whereas the Pediatric Sequential Organ Failure Assessment (pSOFA) score was calculated for all 193 patients using data recorded within the first 24 hours. Admission lactate and PCT were summarized by survival status within shock and non-shock phenotypes. Multivariable logistic regression models adjusted for age and malnutrition assessed biomarker-mortality associations and biomarker x shock interactions. Discrimination was evaluated using shock-stratified receiver operating characteristic (ROC) curves and area under the curve (AUC), with DeLong tests comparing AUCs between phenotypes. RESULTS: Among 193 children, 93 (48.2%) had septic shock, 145 (75.1%) had organ dysfunction, and 79 (40.9%) died in hospital. The median Phoenix Sepsis Score was 2.0 (range, 0--12) among 143 patients, while the median pSOFA score was 4.0 (range: 0--21) among all 193 patients. Mortality was higher in shock than non-shock sepsis (66.7% vs 17.0%; odds ratio (OR): 9.77 (95% confidence interval (CI): 4.96-19.24)) and in those with organ dysfunction (53.1% vs 4.2%; OR = 26.03 (95% CI: 6.09-111.34)). Admission lactate was higher in non-survivors than survivors in both non-shock and shock groups (p<0.05). In adjusted interaction models, each 1 mmol/L increase in lactate (OR = 1.50, 95% CI: 1.11--2.01; p = 0.0075) and each one-unit increase in natural-log--transformed PCT (ln(PCT)) (OR = 1.34, 95% CI: 1.01-1.79; p=0.0458) were associated with mortality in non-shock sepsis. The lactate x shock interaction (OR = 0.76, 95% CI: 0.55--1.05; p = 0.092) and ln(PCT) x shock interaction (OR = 0.74, 95% CI: 0.52--1.07; p = 0.114) were not statistically significant. Shock-stratified ROC curve analysis showed better discrimination in non-shock than shock for lactate (AUC: 0.76 (95% CI: 0.67-0.85) vs 0.62 (95% CI: 0.40-0.83); DeLong p=0.233) and modest discrimination for natural-log-transformed PCT [ln(PCT)] in both phenotypes (AUC: 0.65 (95% CI: 0.55-0.75) vs 0.61 (95% CI: 0.41-0.80); DeLong p=0.695). CONCLUSION: Admission lactate showed moderate discrimination for in-hospital mortality in non-shock sepsis, whereas discrimination was lower in septic shock. PCT showed modest discrimination across phenotypes. Although AUCs were numerically higher in non-shock sepsis, between-phenotype differences were not statistically significant, supporting phenotype-based interpretation and the need for external validation. FAU - Vo, Thi Van AU - Vo TV AD - Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam. FAU - Lu, Dien Tri AU - Lu DT AD - Department of General Nursing, Internal Medicine Program, Faculty of Nursing and Medical Technology, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam. FAU - Thai, Dien Minh AU - Thai DM AD - Faculty of Medicine, Nam Can Tho University, Can Tho, Vietnam. LA - eng PT - Journal Article DEP - 20260803 PL - Iran TA - Arch Acad Emerg Med JT - Archives of academic emergency medicine JID - 101740147 PMC - PMC13542529 OTO - NOTNLM OT - Biomarkers OT - Lactic acid OT - Pediatrics OT - Procalcitonin OT - Sepsis OT - Shock, septic COIS- The authors declare no conflict of interest. EDAT- 2026/09/06 01:18 MHDA- 2026/09/06 01:19 PMCR- 2026/08/03 CRDT- 2026/09/05 09:05 PHST- 2026/09/06 01:19 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 09:05 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.22037/aaem.v14i1.3029 [doi] PST - epublish SO - Arch Acad Emerg Med. 2026 Aug 3;14(1):e34. doi: 10.22037/aaem.v14i1.3029. eCollection 2026. PMID- 42697107 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 2211-0356 (Electronic) IS - 2211-0348 (Linking) VI - 115 DP - 2026 Nov TI - Longitudinal stability of dietary intake patterns in pediatric-onset multiple sclerosis: A multicenter prospective cohort study. PG - 107677 LID - S2211-0348(26)00712-1 [pii] LID - 10.1016/j.msard.2026.107677 [doi] AB - BACKGROUND: Diet may influence MS activity, but most studies use a single dietary measure. The stability of diet over time in pediatric-onset MS (POMS) is unclear. OBJECTIVES: To evaluate the reproducibility and short-term temporal stability of dietary intake in youth with POMS using repeated food frequency questionnaires (FFQ). METHODS: This longitudinal study included participants with a baseline FFQ (the Block Kids Food Screener, 2014). Intraclass correlation coefficients (ICCs) were estimated using random-intercept mixed-effects models to quantify the relative contributions of between-person and within-person variability. Temporal trends in intake were assessed by modeling time since baseline as a fixed effect, using log-transformed dietary variables to estimate percent change over time. RESULTS: Of 419 FFQs from 195 participants, 140 (71.8%) completed >/=2 FFQs over a median of 6.5 months (range 2.8-18). ICCs ranged from 0.41 to 0.78 across dietary measures, with the highest reproducibility observed for vegetables and fiber (ICCs 0.78 and 0.72). Log-transformed models showed small declines in several nutrients over time, corresponding to <10% change over a six-month period. CONCLUSIONS: Dietary intake demonstrated moderate to good reproducibility over the 6 to 18 month follow-up period. Vegetable and fiber intake had the strongest reliability. These findings suggest that reported dietary intake assessed by a single or infrequent FFQ may remain reasonably stable over a 6- to 18-month period in longitudinal POMS studies. However, the moderate-to-good reproducibility observed indicates that within-person variability persists and may attenuate diet-disease associations when only a single dietary assessment is available. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Virupakshaiah, Akash AU - Virupakshaiah A AD - UCSF School of Medicine, San Francisco, CA, USA. Electronic address: Akash.Virupakshaiah@ucsf.edu. FAU - Schoeps, Vinicius A AU - Schoeps VA AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Chang, Gina AU - Chang G AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Waltz, Michael AU - Waltz M AD - University of Utah, Salt Lake City, UT, USA. FAU - Race, Jonathan AU - Race J AD - University of Utah, Salt Lake City, UT, USA. FAU - Mar, Soe AU - Mar S AD - Washington University in St Louis School of Medicine, Department of Neurology, St. Louis, MO, USA. FAU - Francisco, Carla AU - Francisco C AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Casper, T Charles AU - Casper TC AD - University of Utah, Salt Lake City, UT, USA. FAU - Rose, John AU - Rose J AD - University of Utah, Salt Lake City, UT, USA. FAU - Rodriguez, Moses AU - Rodriguez M AD - Mayo Clinic, Rochester, MN, USA. FAU - Tillema, Jan-Mendelt AU - Tillema JM AD - Mayo Clinic, Rochester, MN, USA. FAU - Chitnis, Tanuja AU - Chitnis T AD - Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Gorman, Mark P AU - Gorman MP AD - Boston Children's Hospital, Boston, MA, USA. FAU - Benson, Leslie A AU - Benson LA AD - Boston Children's Hospital, Boston, MA, USA. FAU - Graves, Jennifer S AU - Graves JS AD - Department of Neurosciences, University of California, San Diego, CA, USA. FAU - Rensel, Mary AU - Rensel M AD - Cleveland Clinic, Cleveland, OH, USA. FAU - Abrams, Aaron AU - Abrams A AD - Cleveland Clinic, Cleveland, OH, USA. FAU - Krupp, Lauren B AU - Krupp LB AD - NYU Langone Health, NY, NY, USA. FAU - O'Neill, Kimberly A AU - O'Neill KA AD - NYU Langone Health, NY, NY, USA. FAU - Lotze, Timothy E AU - Lotze TE AD - Texas Children's Hospital, Houston, TX, USA. FAU - Aaen, Gregory AU - Aaen G AD - Loma Linda University Children's Hospital, Loma Linda, CA, USA. FAU - Wheeler, Yolanda AU - Wheeler Y AD - University of Alabama at Birmingham, Birmingham, AL, USA. FAU - Schreiner, Teri AU - Schreiner T AD - Children's Hospital Colorado, Denver, CO, USA. FAU - Waldman, Amy T AU - Waldman AT AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Chong, Janet AU - Chong J AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Titcomb, Tyler J AU - Titcomb TJ AD - Department of Dietetics and Nutrition, University of Kansas Medical Center, United States. FAU - Tremlett, Helen AU - Tremlett H AD - Division of Neurology, Department of Medicine, The University of British Columbia, Canada. FAU - Waubant, Emmanuelle AU - Waubant E AD - UCSF School of Medicine, San Francisco, CA, USA. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260823 PL - Netherlands TA - Mult Scler Relat Disord JT - Multiple sclerosis and related disorders JID - 101580247 SB - IM MH - Humans MH - Female MH - Longitudinal Studies MH - Adolescent MH - Male MH - Child MH - Reproducibility of Results MH - *Multiple Sclerosis/epidemiology MH - *Diet MH - Prospective Studies MH - Diet Surveys MH - *Feeding Behavior MH - Age of Onset OTO - NOTNLM OT - Diet OT - Dietary assessment OT - Food frequency questionnaire OT - Pediatric-onset multiple sclerosis COIS- Declaration of competing interest None reported. EDAT- 2026/09/04 23:36 MHDA- 2026/10/24 05:34 CRDT- 2026/09/04 18:10 PHST- 2026/03/14 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/10/24 05:34 [medline] PHST- 2026/09/04 23:36 [pubmed] PHST- 2026/09/04 18:10 [entrez] AID - S2211-0348(26)00712-1 [pii] AID - 10.1016/j.msard.2026.107677 [doi] PST - ppublish SO - Mult Scler Relat Disord. 2026 Nov;115:107677. doi: 10.1016/j.msard.2026.107677. Epub 2026 Aug 23. PMID- 42695814 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260911 IS - 1364-6893 (Electronic) IS - 0144-3615 (Linking) VI - 46 IP - 1 DP - 2026 Dec TI - Predicting Category II and III foetal heart rate patterns during epidural analgesia: a retrospective cohort study. PG - 2721398 LID - 10.1080/01443615.2026.2721398 [doi] AB - BACKGROUND: This study aimed to identify predictors and develop a multivariable prediction model for Category II and III foetal heart rate (FHR) patterns in parturients undergoing labour epidural analgesia (LEA). METHODS: A retrospective cohort study of 237 parturients receiving LEA was conducted. To address the multicollinearity of 18 intrapartum variables, least absolute shrinkage and selection operator (LASSO) regression and cross-validation were used for feature selection. A predictive nomogram was constructed and internally validated. Model performance was evaluated by the area under the receiver operating characteristic curve (AUC), calibration plots, and Decision Curve Analysis (DCA). RESULTS: Abnormal FHR patterns (Category II and III) occurred in 168 (70.9%) parturients. The LASSO algorithm identified 11 predictors. Multivariable logistic regression demonstrated that maternal intrapartum temperature (OR = 3.518), initial LEA bolus count (OR = 3.625), body mass index (BMI), and oxytocin dosage were independent predictors associated with abnormal FHR patterns. The constructed nomogram demonstrated good discrimination (AUC = 0.800) and good calibration. DCA demonstrated potential clinical net benefit across a wide range of threshold probabilities (0.02-0.99). CONCLUSIONS: We developed and internally validated an 11-variable nomogram (AUC = 0.800) to predict abnormal FHR patterns during LEA. By integrating routinely available clinical variables, the nomogram facilitate early risk stratification and support individualised intrapartum management. TRIAL REGISTRATION: Clinical trial registration: (https://www.chictr.org.cn ChiCTR2300073493; registered 12th July 2023). FAU - Li, Bing AU - Li B AD - Jinan University, Guangzhou, Guangdong, China. AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Wang, Qiqi AU - Wang Q AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Xie, Yuemei AU - Xie Y AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Chen, Liurong AU - Chen L AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Jia, Junxiang AU - Jia J AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Song, Xingrong AU - Song X AD - Jinan University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article DEP - 20260904 PL - England TA - J Obstet Gynaecol JT - Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology JID - 8309140 RN - 50-56-6 (Oxytocin) SB - IM MH - Adult MH - Female MH - Humans MH - Pregnancy MH - *Analgesia, Epidural/adverse effects/methods MH - *Analgesia, Obstetrical/adverse effects/methods MH - *Heart Rate, Fetal/physiology MH - Nomograms MH - Oxytocin/administration & dosage MH - Prediction Algorithms MH - Retrospective Studies MH - Cohort Studies OAB - Labour epidural analgesia is a safe and effective method of pain relief during childbirth. However, it can sometimes be accompanied by temporary changes in the baby's heart rate. At present, it is difficult for clinicians to identify in advance which mothers are more likely to develop these changes during labour.To address this question, we reviewed the medical records of 237 women who received labour epidural analgesia. Using statistical methods, we evaluated 18 clinical characteristics and identified 11 key predictors of abnormal foetal heart rate patterns. We found that a higher maternal temperature during labour, the need for additional epidural bolus doses shortly after analgesia, a higher body mass index (BMI), and greater oxytocin use were key predictive contributors associated with these heart rate changes.Based on these findings, we developed a simple risk prediction tool that may help clinicians identify women at increased risk earlier during labour. Earlier recognition of higher-risk patients may support closer monitoring and timely consideration of appropriate interventions, such as maternal repositioning, fluid administration, or adjustment of oxytocin when clinically indicated. Further studies are needed to determine whether use of this tool improves maternal and neonatal outcomes in routine clinical practice. OABL- eng OTO - NOTNLM OT - Epidural OT - analgesia OT - cardiotocography OT - foetus OT - nomogram OT - parturition EDAT- 2026/09/04 17:40 MHDA- 2026/09/04 17:41 CRDT- 2026/09/04 12:09 PHST- 2026/09/04 17:41 [medline] PHST- 2026/09/04 17:40 [pubmed] PHST- 2026/09/04 12:09 [entrez] AID - 10.1080/01443615.2026.2721398 [doi] PST - ppublish SO - J Obstet Gynaecol. 2026 Dec;46(1):2721398. doi: 10.1080/01443615.2026.2721398. Epub 2026 Sep 4. PMID- 42695078 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260904 LR - 20260906 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Correlation of Fractional Excretion of Sodium With Renal Scintigraphy and Renal Ultrasonography in Children With Unilateral Ureteropelvic Junction Obstruction Undergoing Pyeloplasty: A Prospective Observational Study. PG - e113947 LID - 10.7759/cureus.113947 [doi] LID - e113947 AB - Introduction Ureteropelvic junction obstruction (UPJO) remains a common pediatric urological condition that often requires surgical intervention, and the search for reliable markers to assess postoperative resolution is ongoing. Partial ureteral obstruction is associated with impaired sodium reabsorption; consequently, animal studies have consistently demonstrated natriuria in models of partial ureteral obstruction. Fractional excretion of sodium (FENa) reflects tubular function by measuring urinary sodium excretion and has been used to differentiate the types of acute kidney injury (AKI). To date, no published studies have evaluated preoperative and postoperative FENa in patients with UPJO to demonstrate postoperative improvement or to determine its correlation with established modalities for assessing renal function, such as renal scintigraphy. Aims This study aimed to evaluate the correlation between FENa and renal scintigraphy, specifically diethylene triamine pentaacetic acid (DTPA) renography, as well as renal ultrasonography (USG), in children with unilateral UPJO before and after pyeloplasty. Methodology A time-bound prospective observational study was conducted in the Department of Pediatric Surgery from October 2021 to April 2023. In children who met the diagnostic criteria for UPJO and required surgical intervention, a urine sample was collected intraoperatively to determine the FENa. The FENa values were then correlated with the findings of renal scintigraphy and renal USG. Results A total of 35 patients with a mean age of 7.03 +/- 5.03 years were included in the study. FENa on the affected side showed a significant inverse correlation with differential renal function (DRF) (r = -0.650, p < 0.001) and renal cortical thickness on USG (r = -0.413, p = 0.009). In contrast, FENa demonstrated a significant positive correlation with the anteroposterior pelvic diameter (APPD) measured on USG (r = 0.506, p = 0.001). Discussion Our findings indicate that improvement in DRF was associated with a reduction in the FENa, suggesting improved tubular sodium handling following pyeloplasty. Greater pelvic dilatation was associated with higher FENa values, both of which decreased after pyeloplasty. Similarly, an increase in renal cortical thickness was associated with a reduction in FENa following surgery. These findings suggest that the FENa may serve as a useful surrogate marker for assessing renal function in patients with unilateral UPJO and for evaluating postoperative improvement in renal function following pyeloplasty. CI - Copyright (c) 2026, B et al. FAU - B, Jagdish AU - B J AD - Pediatric Surgery, All India Institute of Medical Sciences, Rishikesh, IND. FAU - Yhoshu, Enono AU - Yhoshu E AD - Pediatric Surgery, All India Institute of Medical Sciences, Rishikesh, IND. FAU - Gupta, Manish K AU - Gupta MK AD - Pediatric Surgery, All India Institute of Medical Sciences, Rishikesh, IND. FAU - Saini, Sandeep AU - Saini S AD - Nephrology, All India Institute of Medical Sciences, Rishikesh, IND. FAU - Piplani, Rajat AU - Piplani R AD - Pediatric Surgery, All India Institute of Medical Sciences, Rishikesh, IND. FAU - Ahmed, Intezar AU - Ahmed I AD - Pediatric Surgery, All India Institute of Medical Sciences, Rishikesh, IND. FAU - Balija, Satya Sree AU - Balija SS AD - Pediatric Surgery, All India Institute of Medical Sciences, Rishikesh, IND. LA - eng PT - Journal Article DEP - 20260804 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13541082 OTO - NOTNLM OT - children OT - differential renal function OT - dtpa OT - fractional excretion of sodium OT - pediatric urology OT - pyeloplasty OT - radionuclide imaging OT - ureteropelvic junction obstruction COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee issued approval AIIMS IEC/21/602. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/04 17:40 MHDA- 2026/09/04 17:41 PMCR- 2026/08/04 CRDT- 2026/09/04 11:07 PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/04 17:41 [medline] PHST- 2026/09/04 17:40 [pubmed] PHST- 2026/09/04 11:07 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.7759/cureus.113947 [doi] PST - epublish SO - Cureus. 2026 Aug 4;18(8):e113947. doi: 10.7759/cureus.113947. eCollection 2026 Aug. PMID- 42694496 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260923 IS - 2330-2941 (Electronic) IS - 2165-7971 (Print) IS - 2165-7971 (Linking) VI - 16 DP - 2026 TI - Parent Perspectives on Dietary and Nutraceutical Therapies in Autism Spectrum Disorder: A Qualitative Thematic Analysis Using a Large Language Model. PG - 17-30 LID - 10.14200/jrm.2026.0001 [doi] AB - OBJECTIVE: To explore how parents of children with autism spectrum disorder (ASD) implement dietary and nutraceutical therapies at home, and to understand the challenges, facilitators, and perceived outcomes that shape their use in real-world settings. DESIGN: A qualitative study using abductive thematic analysis to explore parent-reported experiences with implementing dietary and nutraceutical strategies for their children with ASD. SETTING: Remote interviews conducted with parents residing in Canada and the United States. PARTICIPANTS: A total of 10 semi-structured interviews were completed with 12 parents of children aged <18 years with ASD. Participants represented diverse regions, educational backgrounds, household structures, and linguistic environments. OUTCOME MEASURES: Parent perspectives on feasibility, decision-making processes, child responses, and perceived barriers or supports associated with dietary and nutraceutical strategies. RESULTS: Six themes were identified from parent interviews describing challenges in implementing dietary and nutraceutical interventions for children with ASD. These included parents as architects of care, in which caregivers assumed responsibility for researching, coordinating, and evaluating interventions; food as medicine and messenger, wherein behavioral and gastrointestinal responses served as real-time indicators of effectiveness; emotional weight and resilience, reflecting the psychological and practical burden experienced by caregivers; when systems fail, describing fragmented or insufficient medical guidance; compliance and the complexity of control, shaped by sensory sensitivities, rigid food preferences, family dynamics, and child autonomy; and rejection of one-size-fits-all solutions, emphasizing individualized, iterative approaches over standardized protocols. CONCLUSIONS: Parents face numerous sensory, emotional, and systemic challenges when attempting dietary and nutraceutical therapies for children with ASD. Greater clinical support and more individualized, evidence-informed guidance are needed to help families apply these strategies sustainably and determine which children are most likely to benefit. FAU - Baucum, Jaclyn AU - Baucum J AD - National University of Natural Medicine, Portland, OR, USA. FAU - Memauri, Tessa AU - Memauri T AD - University of Western States, Portland, OR, USA. FAU - Zwickey, Heather AU - Zwickey H AD - National University of Natural Medicine, Portland, OR, USA. AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. AD - Oregon Health and Sciences University, Portland, OR, USA. LA - eng GR - R25 DK130848/DK/NIDDK NIH HHS/United States GR - R90 AT008924/AT/NCCIH NIH HHS/United States GR - U24 AT012549/AT/NCCIH NIH HHS/United States PT - Journal Article DEP - 20260815 PL - United States TA - J Restor Med JT - Journal of restorative medicine JID - 101639173 PMC - PMC13539541 MID - NIHMS2204728 OTO - NOTNLM OT - Autism spectrum disorder OT - Diet, food, and nutrition OT - Large language models OT - Parents/guardians COIS- COMPETING INTERESTS The authors declare that they have no competing interests. EDAT- 2026/09/04 11:39 MHDA- 2026/09/04 11:40 PMCR- 2026/09/04 CRDT- 2026/09/04 09:03 PHST- 2026/09/04 11:40 [medline] PHST- 2026/09/04 11:39 [pubmed] PHST- 2026/09/04 09:03 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - 10.14200/jrm.2026.0001 [doi] PST - ppublish SO - J Restor Med. 2026;16:17-30. doi: 10.14200/jrm.2026.0001. Epub 2026 Aug 15. PMID- 42693933 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1367-4811 (Electronic) IS - 1367-4803 (Print) IS - 1367-4803 (Linking) VI - 42 IP - 9 DP - 2026 Aug 31 TI - Revealing subject-specific temporal patterns from longitudinal data. LID - 10.1093/bioinformatics/btag658 [doi] LID - btag658 AB - MOTIVATION: Temporal multivariate data are ubiquitous in many domains, for instance, being collected over time at planned visits (every few months/years) in longitudinal cohorts, or every few minutes/hours in challenge tests. The analysis of such data often focuses on revealing the underlying temporal patterns common across subjects. However, there are subject-specific differences in temporal patterns, which hold the promise to enhance our understanding of underlying mechanisms and facilitate personalized approaches. Nevertheless, extracting subject-specific temporal patterns from longitudinal multivariate data reliably is an open challenge. RESULTS: We introduce coupled matrix factorizations (CMFs) as effective tools to capture subject-specific temporal patterns focusing on two novel applications: analysis of longitudinal metabolomics data and sensitization data. Our analysis shows that CMF models reliably capture subject-specific (shape) differences in temporal patterns with the promise to reveal further insights compared to the state of the art. In metabolomics, CMF models reveal differences in metabolic responses of individuals (in a postprandial meal challenge) according to anthropometric and insulin sensitivity measures. In sensitization data analysis, CMF-based methods capture differences in temporal trajectories of children according to delivery/birth mode and atopic disease diagnosis. We demonstrate the reliability of extracted patterns using reproducibility and replicability. AVAILABILITY AND IMPLEMENTATION: The code is available on github.com/cchatzis/Revealing-Subject-specific-Temporal-Patterns-from-Longitudinal-Data and doi.org/10.5281/zenodo.22084338. Clinical data are not publicly available due to privacy reasons. Data can be made available under a joint research collaboration by contacting COPSAC (administration@dbac.dk). CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Chatzis, Christos AU - Chatzis C AD - Department of Data Science and Knowledge Discovery, Simula Metropolitan Center for Digital Engineering, Oslo, 0170, Norway. AD - Faculty of Technology, Art and Design, Oslo Metropolitan University, Oslo, 0166, Norway. FAU - Horner, David AU - Horner D AUID- ORCID: 0000-0002-0200-4561 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark. FAU - Bro, Rasmus AU - Bro R AD - Department of Food Science, University of Copenhagen, Copenhagen, 1958, Denmark. FAU - Schoos, Ann-Marie Malby AU - Schoos AM AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital-Naestved, Slagelse and Ringsted, Slagelse, 4200, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, 2650, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, 2200, Denmark. FAU - Rasmussen, Morten A AU - Rasmussen MA AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark. AD - Department of Food Science, University of Copenhagen, Copenhagen, 1958, Denmark. FAU - Acar, Evrim AU - Acar E AUID- ORCID: 0000-0002-3737-292X AD - Department of Data Science and Knowledge Discovery, Simula Metropolitan Center for Digital Engineering, Oslo, 0170, Norway. LA - eng GR - NNF23SA0087869/Novo Nordisk Foundation/ PT - Journal Article PL - England TA - Bioinformatics JT - Bioinformatics (Oxford, England) JID - 9808944 SB - IM MH - Humans MH - *Metabolomics/methods MH - Longitudinal Studies MH - Algorithms MH - *Computational Biology/methods PMC - PMC13623513 COIS- Ann-Marie Malby Schoos has received payment as a speaker from Thermo Fisher Scientific. EDAT- 2026/09/04 05:35 MHDA- 2026/09/30 05:30 PMCR- 2026/09/04 CRDT- 2026/09/04 04:13 PHST- 2026/01/30 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/09/30 05:30 [medline] PHST- 2026/09/04 05:35 [pubmed] PHST- 2026/09/04 04:13 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - 8785290 [pii] AID - btag658 [pii] AID - 10.1093/bioinformatics/btag658 [doi] PST - ppublish SO - Bioinformatics. 2026 Aug 31;42(9):btag658. doi: 10.1093/bioinformatics/btag658. PMID- 42693431 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260906 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 22 TI - Depressive symptom profiles across pregnant, postpartum, and nonperipartum women: measurement invariance and differential item functioning analyses of 2005-2021 NHANES data. LID - 10.1186/s12889-026-28575-8 [doi] LID - 2523 AB - BACKGROUND: The DSM-5-TR classifies peripartum depression as symptomatically indistinguishable from major depressive disorder (MDD). However, evidence suggests that depressive symptom profiles may differ among pregnant, postpartum, and nonperipartum (NPP) women. This study used 2005-2021 National Health and Nutrition Examination Survey data to evaluate Patient Health Questionnaire-9 (PHQ-9) depressive symptoms and assessed measurement equivalence across these groups. METHODS: Measurement invariance (MI) and differential item functioning (DIF) analyses included 632 pregnant, 385 postpartum, and 6,503 NPP women (aged 15-49 years). After confirming the PHQ-9 factor structure, we evaluated MI using multigroup confirmatory factor analysis (MGCFA) and assessed DIF using ordinal logistic regression and item response theory. In MGCFA, model changes supported invariance (measurement equivalence between groups) if DeltaCFI >/= -0.010 together with DeltaRMSEA /= -0.010 together with DeltaRMSEA /= 0.035. RESULTS: A two-factor PHQ-9 model was used. The cognitive-affective factor included anhedonia, depressed mood, guilt/worthlessness, concentration difficulty, psychomotor changes, and suicidal ideation. The somatic factor included sleep disturbance, fatigue, and appetite changes. MGCFA supported metric (DeltaCFI = -0.0005, DeltaRMSEA = -0.0001, DeltaSRMR = 0.0027), scalar (DeltaCFI = 0.0004 and DeltaSRMR = -0.0024), and strict invariance (DeltaCFI and DeltaSRMR < 0.0001). Statistically significant DIF emerged between pregnant and NPP women (guilt/worthlessness, psychomotor changes, fatigue, and appetite changes), postpartum and NPP women (sleep disturbance and fatigue), and pregnant and postpartum women (sleep disturbance). However, all statistically significant DIF effects were modest and of minimal clinical relevance (total DIF pseudo-R(2) difference /=3.16). Serum 25-(OH)D, IGF-1, and lipid profiles [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)] were measured. Binary logistic regression analysis and receiver operating characteristic (ROC) analyses were performed to investigate the association between IR and these biomarkers. RESULTS: Fasting insulin and HOMA-IR levels were significantly higher in the insulin-resistant group than in the insulin-sensitive group (p < 0.001). Compared with the insulin-sensitive group, levels of 25-(OH)D, IGF-1, and HDL-C were significantly lower in the insulin-resistant group (p < 0.001, p = 0.032, and p = 0.023, respectively), while TG and LDL-C levels were significantly higher (p < 0.001). No significant difference was observed in TC levels between the two groups (p = 0.334). Multivariate analysis identified 25-(OH)D (odds ratio [OR] = 0.934, 95% confidence interval [CI]: 0.877-0.995, p = 0.035), IGF-1 >238.68 (OR = 0.303, 95% CI: 0.103-0.894, p = 0.031), TG (OR = 3.979, 95% CI: 1.461-10.835, p = 0.007), and LDL-C (OR = 2.625, 95% CI: 1.398-4.928, p = 0.003) as independent factors associated with IR in children with obesity. ROC analysis showed that the areas under the curves (AUCs) for 25-(OH)D, IGF-1, TG, LDL-C, and the combined indicator were 0.692, 0.612, 0.775, 0.747, and 0.856, respectively (p < 0.001, p = 0.025, p < 0.001, p < 0.001, and p < 0.001). CONCLUSION: In children with obesity, serum 25-(OH)D, IGF-1, TG, and LDL-C are significantly associated with IR. CI - Copyright: (c) 2026 The Author(s). Published by IMR Press. FAU - Chu, Zhufei AU - Chu Z AD - Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, 315400 Ningbo, Zhejiang, China. FAU - Liu, Yue AU - Liu Y AD - Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, 315400 Ningbo, Zhejiang, China. FAU - Ye, Kejun AU - Ye K AD - Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, 315400 Ningbo, Zhejiang, China. LA - eng PT - Journal Article PL - Singapore TA - Br J Hosp Med (Lond) JT - British journal of hospital medicine (London, England : 2005) JID - 101257109 RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) RN - 0 (Lipids) SB - IM MH - Humans MH - *Insulin Resistance/physiology MH - *Insulin-Like Growth Factor I/analysis/metabolism MH - *Vitamin D/analogs & derivatives/blood MH - Male MH - Female MH - Child MH - Retrospective Studies MH - *Lipids/blood MH - *Pediatric Obesity/blood OTO - NOTNLM OT - 25-hydroxyvitamin D OT - insulin resistance OT - insulin-like growth factor-1 OT - pediatric obesity EDAT- 2026/09/03 17:36 MHDA- 2026/09/03 17:37 CRDT- 2026/09/03 11:49 PHST- 2025/10/31 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/09/03 17:37 [medline] PHST- 2026/09/03 17:36 [pubmed] PHST- 2026/09/03 11:49 [entrez] AID - S1750-8460(26)03489-0 [pii] AID - 10.31083/BJHM56972 [doi] PST - ppublish SO - Br J Hosp Med (Lond). 2026 Aug 12;87(8):56972. doi: 10.31083/BJHM56972. PMID- 42689455 OWN - NLM STAT- Publisher LR - 20260903 IS - 1539-2570 (Electronic) IS - 0271-6798 (Linking) DP - 2026 Sep 3 TI - A Simplified Method for Talocalcaneal Coalition Excision. LID - 10.1097/BPO.0000000000003456 [doi] AB - BACKGROUND: Talocalcaneal (TC) coalitions are a common cause of hindfoot pain in adolescents. Resection is effective when the posterior facet is preserved but can be technically demanding, with risk of incomplete resection and prolonged operative time. This study describes a simplified technique for TC coalition excision and compares its outcomes with traditional methods. METHODS: A retrospective review was performed of patients undergoing isolated TC coalition excision with autogenous fat graft interposition at a single pediatric institution (2001 to 2025). Patients with prior surgery, neuromuscular or syndromic conditions, or concomitant procedures were excluded. Forty-eight patients (54 feet) met the inclusion criteria: 39 feet underwent traditional excision, and 15 feet underwent a simplified technique using converging Kirschner wires to guide resection. Outcomes included tourniquet time, anesthesia time, procedural cost, and perioperative complications. Costs were estimated using institutional per-minute operating room rates. Statistical significance was set at P<0.05. RESULTS: There were no differences between groups in age, sex, body mass index, or prevalence of flatfoot deformity. The traditional group had a higher proportion of osseous coalitions (51.3% vs. 13.3%, P=0.04). Tourniquet time (93.4+/- 20.5 vs. 47.5+/- 9.9 min, P<0.0001), total anesthesia time (118.6+/-30.9 vs. 58.9+/-14.2, P<0.0001), direct cost ($1987 vs. $986, P<0.0001), and total cost ($5819 vs. $2887, P<0.0001) were all significantly lower in the simplified method group. No perioperative complications occurred in either group. At a mean follow-up of 2.1 years (range: 0.10 to 8.2 y), there were no differences in complications or secondary procedures. CONCLUSION: The simplified technique for TC coalition excision using converging Kirschner wires is associated with reduced operative time and cost without increased complications. This method provides a reproducible and efficient alternative to traditional resection techniques. LEVEL OF EVIDENCE: Level III-therapeutic. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Lam, Aaron AU - Lam A AD - Baylor Scott and White Orthopedic Associates of Dallas. FAU - Hartman, Rusty AU - Hartman R AD - Scottish Rite for Children, Dallas, TX. FAU - Coe, Kelsie M AU - Coe KM AD - Penn State Health, Hershey, PA. FAU - O'Sullivan, Michael AU - O'Sullivan M AD - Children's Health Ireland at Temple Street Hospital, Dublin, Ireland. FAU - Zide, Jacob AU - Zide J AD - Baylor Scott and White Orthopedic Associates of Dallas. AD - Scottish Rite for Children, Dallas, TX. FAU - Riccio, Anthony I AU - Riccio AI AUID- ORCID: 0000-0002-8386-9312 AD - Scottish Rite for Children, Dallas, TX. LA - eng PT - Journal Article DEP - 20260903 PL - United States TA - J Pediatr Orthop JT - Journal of pediatric orthopedics JID - 8109053 SB - IM OTO - NOTNLM OT - coalition OT - coalition excision OT - coalition excision technique OT - kirschner wires OT - talocalcaneal coalition COIS- The authors declare no conflicts of interest. EDAT- 2026/09/03 17:36 MHDA- 2026/09/03 17:36 CRDT- 2026/09/03 11:19 PHST- 2026/09/03 17:36 [medline] PHST- 2026/09/03 17:36 [pubmed] PHST- 2026/09/03 11:19 [entrez] AID - 01241398-990000000-01295 [pii] AID - 10.1097/BPO.0000000000003456 [doi] PST - aheadofprint SO - J Pediatr Orthop. 2026 Sep 3. doi: 10.1097/BPO.0000000000003456. PMID- 42689310 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 51 IP - 4 DP - 2026 Jul-Aug TI - In-Service Training of Stakeholders Working for Particularly Vulnerable Tribal Groups (PVTGs) in an Eastern State of India: A Pre and Post- Training Assessment. PG - 686-693 LID - 10.4103/ijcm.ijcm_693_25 [doi] AB - BACKGROUND: Particularly vulnerable tribal groups (PVTGs) are among the most marginalized tribal communities in India. The uptake of government-led health and nutrition programmes by them is low owing to the geographical remoteness of their habitats, communication gaps between service providers and PVTG communities, and distinct cultural beliefs. Under the "Jiban Sampark" ("Connection with Life") project-a collaboration between the Government of Odisha, United Nations Children's Fund (UNICEF), and AIIMS Bhubaneswar-a structured training of trainers (ToT) programme was implemented to build the capacity of stakeholders serving these communities. The objective of this study was to implement and assess the effectiveness of the training programme on the knowledge of stakeholders working for PVTGs in tribal districts of Odisha, an eastern state of India. METHODS: A single-group pre-post (before-after) interventional study was conducted in 12 tribal districts from April 2019 to January 2020. Six modules were developed and vetted by subject experts for the training of different stakeholders including health officials, officials from Women and Child Development (WCD) departments, Non-Governmental Organization (NGO) personnel, and functionaries of the Odisha Livelihood Mission (OLM) and the Odisha PVTG Empowerment and Livelihood Programme (OPELIP). Three-day residential trainings covered six modules; knowledge was assessed across five domains-childhood malnutrition, adolescent health, antenatal and postnatal care, newborn care and immunization, and communication in service delivery-using a pretested, content-validated 20-item questionnaire administered immediately before and after training to 231 of the 242 participants trained. RESULTS: The mean total knowledge score improved significantly after training compared with before training (13.80 +/- 3.78 vs 11.55 +/- 5.19; paired t-test, P < 0.001). All five domains improved significantly by McNemar's test (all P < 0.0001). The pre-test overall knowledge was lowest among OPELIP staff and health functionaries (8.41 +/- 3.03 and 9.16 +/- 2.49, respectively). The post-test scores of health functionaries were highest across all domains, and their overall improvement was statistically significant (9.16 +/- 2.49 vs 15.48 +/- 4.19; P < 0.001). WCD functionaries, who had the highest baseline score, showed a significant decline in total score (14.85 +/- 6.37 vs 12.82 +/- 3.96; P = 0.023). CONCLUSION: The assessment of pre- and post-test results revealed a significant improvement in the knowledge of stakeholders across most domains and cadres. Hence, an administrative mechanism within the government system is needed to impart training to all stakeholders at regular intervals and to monitor the cascade training of frontline workers (FLWs). CI - Copyright: (c) 2026 Indian Journal of Community Medicine. FAU - Bhatia, Vikas AU - Bhatia V AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Giri, Prajna Paramita AU - Giri PP AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Taywade, Manish AU - Taywade M AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Parida, Swayam Pragyan AU - Parida SP AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Behera, Binod Kumar AU - Behera BK AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Das, Sandeep AU - Das S AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. LA - eng PT - Journal Article DEP - 20260813 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC13537773 OTO - NOTNLM OT - Knowledge assessment OT - PVTG OT - scheduled tribe OT - training OT - tribal COIS- There are no conflicts of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/07/01 CRDT- 2026/09/03 11:08 PHST- 2025/09/11 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 11:08 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - IJCM-51-686 [pii] AID - 10.4103/ijcm.ijcm_693_25 [doi] PST - ppublish SO - Indian J Community Med. 2026 Jul-Aug;51(4):686-693. doi: 10.4103/ijcm.ijcm_693_25. Epub 2026 Aug 13. PMID- 42689159 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Chrononutrition and Pediatric Metabolic Health: An Integrative Review of Circadian Biology and Early-Day Metabolic Regulation. PG - e113864 LID - 10.7759/cureus.113864 [doi] LID - e113864 AB - Childhood obesity remains one of the most important public health challenges worldwide, resulting from the complex interaction of biological, behavioral, environmental, and socioeconomic factors. Although substantial advances have been achieved in nutritional science, increasing evidence suggests that metabolic regulation is influenced not only by dietary composition but also by biological timing. This narrative conceptual review synthesizes current knowledge from chronobiology, chrononutrition, pediatric endocrinology, nutritional physiology, and behavioral nutrition to examine how early-day eating patterns may influence metabolic regulation during childhood. The available evidence indicates that metabolic responses emerge from the coordinated interaction among circadian organization, endocrine signaling, dietary quality, feeding behavior, and developmental physiology rather than from isolated nutritional variables alone. Based on this integrated interpretation, this review proposes the concept of the Early-Day Metabolic Window (EMW), defined as the physiological period immediately following overnight fasting during which circadian synchronization, endocrine responsiveness, metabolic flexibility, and nutrient sensing converge during the transition toward daytime metabolism. Building upon this concept, we present the Costa Reset Conceptual Model, an integrative physiological framework designed to organize current evidence into a unified interpretation of early-day metabolic regulation. Rather than proposing a new biological mechanism or a specific dietary intervention, the model provides a conceptual structure through which biological timing and nutritional exposures may be interpreted as interacting determinants of pediatric metabolic regulation. Although the proposed framework remains conceptual and requires prospective experimental validation, it generates biologically plausible and testable hypotheses that may guide future clinical and translational research. Integrating chrononutrition and temporal nutritional physiology into pediatric nutritional science may contribute to a more comprehensive understanding of childhood metabolic health and support future chrononutrition-based preventive and therapeutic strategies. CI - Copyright (c) 2026, Costa et al. FAU - Costa, Bruno AU - Costa B AD - Nutrition, Private Practice, Santos, BRA. LA - eng PT - Journal Article PT - Review DEP - 20260803 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13537081 OTO - NOTNLM OT - child health OT - chronobiology OT - chrononutrition OT - circadian rhythm OT - early-day metabolic window OT - feeding behavior OT - metabolism OT - pediatric metabolism OT - pediatric obesity COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/03 CRDT- 2026/09/03 10:50 PHST- 2026/08/02 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 10:50 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.7759/cureus.113864 [doi] PST - epublish SO - Cureus. 2026 Aug 3;18(8):e113864. doi: 10.7759/cureus.113864. eCollection 2026 Aug. PMID- 42689141 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Daily fiber supplementation after bariatric surgery demonstrates tolerability and influence on the fecal gut microbiome. PG - 1912097 LID - 10.3389/fnut.2026.1912097 [doi] LID - 1912097 AB - INTRODUCTION: This study assessed the feasibility and tolerance of a 30-day resistant potato starch (RPS) supplement in patients who recently underwent bariatric surgery and its effect on microbial production of fecal short-chain fatty acids (SCFA). METHODS: This clinical trial (ClinicalTrials.gov, identifier: NCT05653648), conducted at Dartmouth Hitchcock Medical Center, provided 30-days of RPS supplement (titration: 24 g for 15 days; 48 g for 15 days) starting 90-days post-op and assessed gastrointestinal symptoms, dietary intake (24 h recall), fecal SCFAs, and fecal gut microbiome (n = 30). RESULTS: The RPS supplement was well tolerated by participants (77% achieving consumption goal), with modest, but significant increases in self-reported gas (p = 0.004) and abdominal rumbling (p = 0.047). It was associated with an increase in the Bifidobacterium genus (LDA score >4, p < 0.001) and specifically, an enrichment of B. faecale/adolescentis (p = 0.006), one of two known primary degraders of RPS. No changes were observed in the abundance of cross-feeders or in SCFA concentrations. Alpha diversity measures were significantly lower post-RPS, and there was no change in species richness. DISCUSSION: This study demonstrated that a RPS supplement is tolerable in post-op bariatric patients and that the gut microbiome is responsive to fiber interventions. RPS increased the abundance of SCFA-producing bacteria but did not alter fecal SCFAs, likely due to competition among cross-feeders. CI - Copyright (c) 2026 Moser, Saxby, Lebby, Letendre, Lange, Mendez, Trus, Honigsberg, Billmeier, Gilbert-Diamond, Dao and Meijer. FAU - Moser, Brandy AU - Moser B AD - Department of Agriculture, Nutrition, and Food Systems, University of New Hampshire, Durham, NH, United States. FAU - Saxby, Solange M AU - Saxby SM AD - Department of Community and Family Medicine, Dartmouth Health, Lebanon, NH, United States. FAU - Lebby, Stephanie AU - Lebby S AD - Section of Obesity Medicine, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Letendre, Jennifer D AU - Letendre JD AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Lange, Sarah AU - Lange S AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Mendez, Marissa A AU - Mendez MA AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Trus, Thadeus L AU - Trus TL AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Honigsberg, Elizabeth AU - Honigsberg E AD - Section of Obesity Medicine, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Billmeier, Sarah E AU - Billmeier SE AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Gilbert-Diamond, Diane AU - Gilbert-Diamond D AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, United States. FAU - Dao, Maria Carlota AU - Dao MC AD - Department of Agriculture, Nutrition, and Food Systems, University of New Hampshire, Durham, NH, United States. FAU - Meijer, Jennifer L AU - Meijer JL AD - Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, United States. LA - eng SI - ClinicalTrials.gov/NCT05653648 PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13536892 OTO - NOTNLM OT - bariatric surgery OT - butyrate OT - fiber OT - gut microbiota OT - obesity OT - potato starch OT - short-chain fatty acids OT - supplementation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 10:48 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 10:48 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fnut.2026.1912097 [doi] PST - epublish SO - Front Nutr. 2026 Aug 19;13:1912097. doi: 10.3389/fnut.2026.1912097. eCollection 2026. PMID- 42688803 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - The moderated mediation effect of physical activity on non-suicidal self-injury: the mediating role of perceived stress and the moderating role of parental support. PG - 1824693 LID - 10.3389/fpsyt.2026.1824693 [doi] LID - 1824693 AB - OBJECTIVES: Non-suicidal self-injury (NSSI) has emerged as a significant public health challenge among adolescents globally. Although physical activity (PA) is widely recognized as a potential protective factor for mental health, the internal mechanisms through which it is associated with specific high-risk behaviors like NSSI remain insufficiently explored. This study aims to construct and validate a moderated mediation model to examine the association between PA and adolescent NSSI, the mediating role of perceived stress, and the boundary conditions set by parental support. METHODS: Utilizing a cross-sectional observational design and a stratified cluster sampling method, 402 adolescents (198 males and 204 females; mean age = 15.23 +/- 1.57 years) were recruited from five middle and high schools (three urban, two rural) in Sichuan Province, China. Participants completed a battery of psychometric instruments, including the Physical Activity Rating Scale-3 (PARS-3), the Perceived Stress Scale-10 (PSS-10), the Inventory of Parent and Peer Attachment (IPPA), and the Deliberate Self-Harm Inventory (DSHI). Data analysis was conducted using SPSS 26.0 and the PROCESS macro (Model 58). RESULTS: PA was significantly and negatively associated with adolescent NSSI (beta = -0.58, p < 0.001). Perceived stress partially mediated this relationship, with the indirect association accounting for 36.21% of the total effect. The substantial direct association (63.79%) suggests that PA may also relate to NSSI through other unmeasured pathways, such as speculative neurobiological adaptations or behavioral replacement. Furthermore, parental support significantly moderated the mediated process. Specifically, parental support moderated both the PA -> perceived stress pathway (beta = 0.15, p = 0.003) and the perceived stress -> NSSI pathway (beta = -0.14, p = 0.005), suggesting that the negative association between PA and stress is stronger under low parental support. CONCLUSIONS: PA serves as a potential protective factor negatively associated with NSSI through both direct and indirect statistical pathways. Parental support functions as a critical environmental buffer; for adolescents lacking parental support, PA serves as a crucial compensatory resource for stress management. These findings offer empirical evidence for the development of integrated family-school intervention strategies for adolescent mental health. CI - Copyright (c) 2026 Wang, Jia and Xu. FAU - Wang, Pengyu AU - Wang P AD - School of Public Administration, Henan University of Economics and Law, Zhengzhou, China. FAU - Jia, Hui AU - Jia H AD - Department of Marine-Sports, Pukyong National University, Busan, Republic of Korea. FAU - Xu, Jie AU - Xu J AD - Sichuan Technology and Business University, Meishan, China. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13535768 OTO - NOTNLM OT - moderated mediation OT - non-suicidal self-injury (NSSI) OT - parental support OT - perceived stress OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 09:56 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 09:56 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1824693 [doi] PST - epublish SO - Front Psychiatry. 2026 Aug 19;17:1824693. doi: 10.3389/fpsyt.2026.1824693. eCollection 2026. PMID- 42688550 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2813-2890 (Electronic) IS - 2813-2890 (Linking) VI - 5 DP - 2026 TI - Adolescent circadian sleep health: a review of multimodal assessment strategies and clinical implications. PG - 1826938 LID - 10.3389/frsle.2026.1826938 [doi] LID - 1826938 AB - The adolescent developmental period is marked by increased social and academic demands, as well as biological changes that lead to profound shifts in sleep and circadian timing. Circadian misalignment, short sleep duration, and irregular sleep patterns are prevalent among adolescents and are linked to a wide range of negative outcomes, including impaired emotional regulation, diminished academic performance, and increased cardiometabolic disease risk. While efforts to promote adolescent sleep health have grown, the multidimensional nature of circadian sleep health remains underassessed in both research and clinical contexts. This review provides conceptual definitions of key circadian sleep health concepts, synthesizing current best practices for measuring circadian sleep health in adolescents across self-report, behavioral, and physiological domains. We organize assessment strategies around three key circadian constructs-chronotype, circadian timing, and circadian alignment-and describe validated tools for each. In addition, we explore measurements of contextual factors influencing circadian function, such as light exposure, meal and exercise timing, pubertal status, and genetic predispositions. Throughout this review, we emphasize the value of a multimodal approach that combines subjective experience with objective biological and behavioral data to improve clinical utility and advance the understanding of circadian sleep health. We conclude by outlining directions for future research, including the need for validated, developmentally appropriate tools and the integration of wearable technologies to improve accessibility and clinical utility. By consolidating core concepts and methodological tools, this review aims to assist researchers and clinicians selecting appropriate assessment strategies and tailoring interventions to improve adolescent circadian sleep health. CI - Copyright (c) 2026 Jex, Larson Downs, Kamhout, Wright, Wright, Zhang and Duraccio. FAU - Jex, Jamon M AU - Jex JM AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Larson Downs, Alyssa AU - Larson Downs A AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Kamhout, Sarah AU - Kamhout S AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Wright, Isabella D AU - Wright ID AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Wright, Andrew AU - Wright A AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Zhang, Victoria AU - Zhang V AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Duraccio, Kara McRae AU - Duraccio KM AD - Department of Psychology, Brigham Young University, Provo, UT, United States. LA - eng PT - Journal Article PT - Review DEP - 20260819 PL - Switzerland TA - Front Sleep JT - Frontiers in sleep JID - 9918451286706676 PMC - PMC13535966 OTO - NOTNLM OT - adolescents OT - chronotype OT - circadian alignment OT - circadian misalignment OT - circadian sleep health OT - circadian timing OT - multimodal assessment OT - sleep health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 09:19 PHST- 2026/03/10 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 09:19 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/frsle.2026.1826938 [doi] PST - epublish SO - Front Sleep. 2026 Aug 19;5:1826938. doi: 10.3389/frsle.2026.1826938. eCollection 2026. PMID- 42688531 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Time-dependent changes in aerobic capacity of acute sub-high altitude exposure in elite youth endurance athletes. PG - 1916986 LID - 10.3389/fphys.2026.1916986 [doi] LID - 1916986 AB - PURPOSE: This study investigated the non-linear, time-dependent alterations in cardiorespiratory fitness, running economy (RE), and metabolic kinetics during the first week of acute exposure to a sub-high altitude (1,300 m) in elite youth endurance athletes. METHODS: Fourteen male national-level middle- and long-distance runners (age: 19.8 +/- 0.7 years; sea-level V O2max : 67.2 +/- 3.8 mL.kg(-)(1).min(-)(1)) completed field-based incremental exhaustion tests on a standard 400-m outdoor track at sea level (T0) and on day 1 (T1, within 18 h post-arrival), day 4 (T2), and day 6 (T3) after rapid rail-based ascent to 1,300 m. Maximal oxygen uptake ( V O2max ), peak running speed ( vV O2max ), and submaximal RE (steady-state V O2 at 12, 14, and 16 km.h(-)(1)) were assessed using an automated metabolic cart. Blood lactate concentration ([La(-)]b) and maximal heart rate (HRmax) were measured. Daily waking morning heart rate (morning HR) and resting arterial oxygen saturation (SpO(2)) were continuously monitored. Training volume was strictly standardized to 70% of the habitual sea-level load. RESULTS: One-way RM ANOVA revealed a significant main effect of time on V O2max ( F[3, 39] = 18.42, p < 0.001, etap2 = 0.59 ). Crucially, polynomial contrasts confirmed a highly significant quadratic trend ( Fquadratic[1, 13] = 34.21, ptrend < 0.001, etap2 = 0.72 ), statistically validating a non-linear V-shaped temporal kinetic profile. V O2max dropped from T1 to a distinct nadir at T2 ( - 7.0% , 95% CI:[60.1, 64.7] mL . kg-1 . min-1, p < 0.001 ), and partially rebounded at T3 . Concurrently, submaximal RE at 14 km/h significantly deteriorated at T2 , as evidenced by a 5.3% increase in distance-specific oxygen cost (from 210.5 +/- 12.4 at T1 to 221.7 +/- 14.2 mL . kg-1 . km-1 at T2 , p = 0.010 ), which also exhibited a significant quadratic pattern ( ptrend = 0.008 ). Post-exercise blood lactate peaked at T2 ( 11.2 +/- 1.4 mmol . L-1, p = 0.015 ), while HRmax remained statistically stable ( F[3, 39] = 0.21, p = 0.885, etap2 = 0.015 ). CONCLUSION: Acute relocation to 1,300 m induces a distinct physiological nadir on Day 4, which may be related to transient autonomic adjustments and respiratory muscle work, rather than hematological adaptations. Early adaptation emerges by Day 6. Coaches may consider closer monitoring and temporary adjustment of training intensity during the early days following ascent, particularly around day 4. CI - Copyright (c) 2026 Feng, Ning, Zhang, Tao, Sun and Wu. FAU - Feng, Junpeng AU - Feng J AD - China Winter Sports College, Beijing Sport University, Beijing, China. FAU - Ning, Fengming AU - Ning F AD - College of Education, Beijing Sport University, Beijing, China. FAU - Zhang, Xuchang AU - Zhang X AD - College of Education, Beijing Sport University, Beijing, China. FAU - Tao, Ye AU - Tao Y AD - College of Education, Beijing Sport University, Beijing, China. FAU - Sun, Mingyue AU - Sun M AD - Department of Physical Education, Beijing City University, Beijing, China. FAU - Wu, Wenqiang AU - Wu W AD - College of Education, Beijing Sport University, Beijing, China. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13534102 OTO - NOTNLM OT - endurance OT - hypoxic acclimatization OT - running economy OT - sub-high altitude OT - youth athletes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 09:16 PHST- 2026/06/23 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 09:16 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fphys.2026.1916986 [doi] PST - epublish SO - Front Physiol. 2026 Aug 19;17:1916986. doi: 10.3389/fphys.2026.1916986. eCollection 2026. PMID- 42688498 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - The role of exercise in post-traumatic stress disorder: clinical evidence, sleep, cognition, and psychotherapy augmentation. PG - 1889239 LID - 10.3389/fpsyt.2026.1889239 [doi] LID - 1889239 AB - Post-traumatic stress disorder (PTSD) constitutes a profoundly incapacitating psychiatric disorder distinguished by the presence of intrusive recollections, heightened arousal, disruptions in sleep patterns, cognitive impairments, and diminished quality of life (QoL). Notwithstanding the advancements achieved in pharmacological treatments and trauma-oriented psychotherapeutic interventions, a considerable number of patients encounter persistent residual symptoms, underscoring the necessity for supplementary therapeutic modalities. This review scrutinizes the nascent role of physical exercise as an adjunctive treatment for PTSD, concentrating on clinical evidence pertinent to the alleviation of symptoms, regulation of sleep, enhancement of cognitive function, and augmentation of the efficacy of trauma-focused psychotherapeutic interventions, particularly exposure-based therapies. Empirical data derived from randomized controlled trials and preliminary studies suggest that modalities such as aerobic exercise, high-intensity interval training, resistance training, and comprehensive exercise regimens may contribute to reductions in the severity of PTSD symptoms, as well as associated anxiety, depression, hyperarousal, and insomnia. Furthermore, exercise interventions have been associated with improvements in cardiorespiratory fitness, mindfulness, interoceptive awareness, and overall psychological QoL across a variety of populations, including veterans, refugees, law enforcement personnel, military service members, and adolescents. Mechanistically, physical exercise appears to augment neuroplasticity through transient elevations in brain-derived neurotrophic factor, modulation of autonomic regulatory functions, and facilitation of fear extinction learning processes. Significantly, aerobic exercise in conjunction with exposure-based psychotherapy has shown promising potential for enhancing long-term clinical outcomes. Collectively, the existing body of evidence suggests that exercise may represent a feasible, safe, and biologically plausible adjunctive intervention for PTSD; however, larger multicenter trials are necessary to establish optimal exercise prescriptions and elucidate the underlying neurobiological mechanisms. CI - Copyright (c) 2026 Li and Li. FAU - Li, Yuyin AU - Li Y AD - Department of Physical Education, Dankook University, Yongin-si, Republic of Korea. FAU - Li, Shuyi AU - Li S AD - School of Physical Education, Shenyang Sport University, Shenyang, China. LA - eng PT - Journal Article PT - Review DEP - 20260819 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13535820 OTO - NOTNLM OT - adjunctive therapy OT - cognition OT - exercise OT - post-traumatic stress disorder OT - psychotherapy augmentation OT - sleep COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 09:08 PHST- 2026/05/23 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 09:08 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1889239 [doi] PST - epublish SO - Front Psychiatry. 2026 Aug 19;17:1889239. doi: 10.3389/fpsyt.2026.1889239. eCollection 2026. PMID- 42688474 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Cultural adaptation, validation, and first application of the Canadian assessment of physical literacy (CAPL-2) in Lithuanian primary school children. PG - 1922697 LID - 10.3389/fspor.2026.1922697 [doi] LID - 1922697 AB - INTRODUCTION: Physical literacy is increasingly recognized as a multidimensional construct that supports lifelong engagement in physical activity. Although the Canadian Assessment of Physical Literacy, second edition (CAPL-2), is one of the most widely used instruments for assessing physical literacy in children, no culturally adapted and validated Lithuanian version has previously been available. This study aimed to translate and culturally adapt CAPL-2 for Lithuanian primary school children, evaluate its psychometric properties, and report the findings from its first application in a national sample. METHODS: CAPL-2 was translated and culturally adapted following established international guidelines, including forward-backward translation, expert review, and pilot testing. The adapted instrument was administered to 846 children aged 8-11 years from 10 Lithuanian schools. Descriptive statistics, Pearson correlations, confirmatory factor analysis, age- and sex-group comparisons, and internal consistency analyses were performed. RESULTS: The Lithuanian CAPL-2 demonstrated good psychometric properties and retained the original four-domain structure (CFI = .963, TLI = .946, RMSEA = .047, SRMR = .040). The Motivation and Confidence domain showed good internal consistency (Cronbach's alpha = .867; McDonald's omega = .87). The mean total CAPL-2 score was 70.25/100. Motivation and Confidence showed the highest domain scores, whereas Knowledge and Understanding demonstrated the weakest associations with the remaining domains and no significant correlation with Daily Behavior. Significant age-related differences were observed for Physical Competence and Knowledge and Understanding. CONCLUSION: The Lithuanian version of CAPL-2 is a valid and culturally appropriate instrument for assessing physical literacy in primary school children. The findings support its use in research, education, and public health and provide a foundation for future national and international studies. CI - (c) 2026 Vizbariene, Mieziene, Rutkauskaite and Emeljanovas. FAU - Vizbariene, Audrone AU - Vizbariene A AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. FAU - Mieziene, Brigita AU - Mieziene B AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. FAU - Rutkauskaite, Renata AU - Rutkauskaite R AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. FAU - Emeljanovas, Arunas AU - Emeljanovas A AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13534132 OTO - NOTNLM OT - CAPL-2 OT - cross-cultural adaptation and validation OT - physical education OT - physical literacy OT - primary school children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor BO declared a past co-authorship/collaboration ("Compatibility of physical education curricula with physical literacy across 40 European countries") with the authors BM and AE. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 08:59 PHST- 2026/06/29 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 08:59 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fspor.2026.1922697 [doi] PST - epublish SO - Front Sports Act Living. 2026 Aug 19;8:1922697. doi: 10.3389/fspor.2026.1922697. eCollection 2026. PMID- 42688404 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2055-2076 (Print) IS - 2055-2076 (Electronic) IS - 2055-2076 (Linking) VI - 12 DP - 2026 Jan-Dec TI - Development of an mHealth tool to prevent chronic childhood malnutrition in Ecuador: A user-centered design approach in developing contexts. PG - 20552076261460352 LID - 10.1177/20552076261460352 [doi] LID - 20552076261460352 AB - BACKGROUND: Chronic malnutrition in children (CMC) remains a pressing public health issue in Ecuador, especially in the rural Sierra communities. Support from community health workers (CHWs) to families during the first 1000 days of life is crucial for prevention. However, CHWs face operational challenges that reduce intervention effectiveness, emphasising the need to develop mobile health (mHealth) tools that are contextually appropriate, culturally relevant, and technically reliable. OBJECTIVE: To design an mHealth tool (called Mikuy) that enables CHWs to implement a family support strategy to prevent CMC in rural Ecuador. METHODS: A user-centered design tailored to the local context was employed, using a mixed participatory methodology involving 99 participants (84 pregnant women or mothers and 15 CHWs). The process unfolded in three iterative stages: (1) analysis of context and needs, (2) design of content and interface, and (3) usability and acceptability assessment. Qualitative techniques included focus groups, a co-design workshop, one-to-one think-aloud sessions, and observations during simulated use. Quantitative methods involved administering usability (SUS) and acceptability (TAM) questionnaires. RESULTS: Participants identified critical needs relating to connectivity and cultural appropriateness. Key features for effectiveness included offline accessibility, language switching (Spanish/Kichwa), household georeferencing, and a system for monitoring home visits. Qualitative observations led to improvements in interface, navigation, and language. The final tool scored highly in usability tests (SUS = 83.75) and acceptability (TAM-PU >/= 4.60). CONCLUSIONS: Mikuy is a culturally adapted and operationally viable mHealth solution that supports CHWs and other community agents in educational and monitoring efforts to prevent CMC in rural areas of the Ecuadorian Sierra. CI - (c) The Author(s) 2026. FAU - Villena-Esponera, Maria Pilar AU - Villena-Esponera MP AD - Facultad de Artes y Ciencias Sociales, Universidad Internacional de La Rioja, Logrono, Spain. RINGGOLD: 247680 FAU - Aguilar Gamarra, Harry AU - Aguilar Gamarra H AUID- ORCID: 0000-0002-7623-7691 AD - Escuela Superior de Ingenieria y Tecnologia (ESIT), Universidad Internacional de La Rioja, Logrono, Spain. RINGGOLD: 247680 FAU - Jerves-Cordova, Carlos AU - Jerves-Cordova C AD - Facultad de Jurisprudencia, Ciencias Sociales y Politicas, Universidad Estatal de Bolivar, Guaranda, Ecuador. RINGGOLD: 27894 FAU - Molina-Recio, Guillermo AU - Molina-Recio G AD - Departamento de Enfermeria, Farmacologia y Fisioterapia, Facultad de Medicina y Enfermeria, Universidad de Cordoba, Cordoba, Spain. AD - Grupo Asociado Estilos de Vida, Innovacion y Salud, Instituto Maimonides de Investigacion Biomedica (IMIBIC), Cordoba, Spain. FAU - Caballero, Marta AU - Caballero M AD - Facultad de Artes y Ciencias Sociales, Universidad Internacional de La Rioja, Logrono, Spain. RINGGOLD: 247680 LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - Digit Health JT - Digital health JID - 101690863 PMC - PMC13535078 OTO - NOTNLM OT - child nutrition disorders OT - community health workers OT - mHealth OT - malnutrition OT - mobile applications OT - user-centered design COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/09/01 CRDT- 2026/09/03 08:31 PHST- 2025/12/01 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 08:31 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 10.1177_20552076261460352 [pii] AID - 10.1177/20552076261460352 [doi] PST - epublish SO - Digit Health. 2026 Sep 1;12:20552076261460352. doi: 10.1177/20552076261460352. eCollection 2026 Jan-Dec. PMID- 42688190 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Clinical correlates of depressed adolescents comorbid with food addiction: a cross-sectional study. PG - 1909728 LID - 10.3389/fpsyt.2026.1909728 [doi] LID - 1909728 AB - BACKGROUND: Food addiction (FA) involves the excessive intake of ultra-processed foods and is prevalent among individuals with major depressive disorder (MDD). Despite this association, evidence regarding FA in adolescents with MDD is limited. This investigation sought to examine the relationship between FA and clinical features in this demographic, aiming to clarify the prevalence of FA and offer theoretical insights for clinical management. METHODS: A total of 194 depressed adolescents were recruited at the Fourth Affiliated Hospital of Anhui Medical University between September 2022 and June 2025. Validated multidimensional scales were used to assess FA, depression, anxiety, perceived stress, and internet addiction (IA). Subsequently, stepwise regression analysis was performed to identify independent factors of FA, and receiver operating characteristic (ROC) curve analysis was conducted for these predictors, with the area under the curve (AUC) calculated. RESULTS: The prevalence of FA in depressed adolescents was 17.5%. Multivariate logistic regression identified BMI (OR = 1.149, 95% CI = 1.051 - 1.257, P = 0.002), anxiety (OR = 1.116, 95% CI = 1.039 - 1.198, P = 0.002), perceived stress (OR = 1.137, 95% CI = 1.030 - 1.254, P = 0.011), and IA (OR = 1.051, 95% CI = 1.020 - 1.083, P = 0.001) as independent risk factors of FA. Furthermore, ROC curve analysis demonstrated that a combined model comprising these four factors exhibited superior discriminatory ability for identifying FA (AUC = 0.861, 95% CI = 0.801 - 0.921, P < 0.001). CONCLUSION: FA affects some adolescents with MDD and is closely associated with BMI, anxiety, perceived stress, and IA. Clinicians should integrate screening for this abnormal eating behavior and related psychosocial factors into routine care. CI - Copyright (c) 2026 Sun, Liu, Tang, Fan, Hao, Zhang and Liu. FAU - Sun, Liling AU - Sun L AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Liu, Lewei AU - Liu L AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Tang, Pei AU - Tang P AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Fan, Haojie AU - Fan H AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Hao, Mingru AU - Hao M AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Zhang, Kai AU - Zhang K AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Liu, Huanzhong AU - Liu H AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13534092 OTO - NOTNLM OT - adolescent OT - clinical characteristics OT - food addiction OT - major depressive disorder OT - receiver operating characteristic COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors HL, KZ declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 07:09 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 07:09 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1909728 [doi] PST - epublish SO - Front Psychiatry. 2026 Aug 19;17:1909728. doi: 10.3389/fpsyt.2026.1909728. eCollection 2026. PMID- 42688108 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Digital health literacy and disordered eating among adolescents: the chain mediating roles of physical activity and problematic social media use. PG - 1937781 LID - 10.3389/fpsyt.2026.1937781 [doi] LID - 1937781 AB - BACKGROUND: Digital environments may increase adolescents' vulnerability to disordered eating through misleading health information and problematic social media use. This study examined the association between digital health literacy and disordered eating, including the independent and serial indirect associations of physical activity and problematic social media use. METHODS: This cross-sectional study included 2,206 adolescents recruited from five secondary schools using purposive and convenience sampling. Participants had a mean age of 14.50 years (SD = 1.76). Digital health literacy, disordered eating, physical activity, and problematic social media use were assessed using validated scales. Correlation and bootstrap-based regression analyses were conducted to estimate the specific and serial indirect associations. RESULTS: Digital health literacy was negatively associated with disordered eating and problematic social media use and positively associated with physical activity. The total association between digital health literacy and disordered eating was -0.324 (95% CI [-0.365, -0.283]), including a direct association of -0.135 (95% CI [-0.177, -0.092]). Indirect associations were observed through physical activity (-0.098, 95% CI [-0.121, -0.077]), problematic social media use (-0.072, 95% CI [-0.089, -0.057]), and physical activity followed by problematic social media use (-0.019, 95% CI [-0.024, -0.015]). CONCLUSION: Digital health literacy was associated with disordered eating through independent and serial indirect associations involving physical activity and problematic social media use. These findings suggest the value of coordinated school- and family-based strategies integrating digital health literacy education, physical activity promotion, responsible social media use, and early identification of disordered eating. CI - Copyright (c) 2026 Ding, Zhao, Qu, Tang, Shang, Lyu and Li. FAU - Ding, Xuyao AU - Ding X AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Zhao, Chuyuan AU - Zhao C AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Qu, Jiaqi AU - Qu J AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Tang, Chen AU - Tang C AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Shang, Chuxi AU - Shang C AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Lyu, Jianing AU - Lyu J AD - Body-Brain-Mind Laboratory, School of Psychology, Wuhan Sports University, Wuhan, China. FAU - Li, Zhen AU - Li Z AD - School of Physical Education, Henan Kaifeng College of Science Technology and Communication, Kaifeng, Henan, China. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13533913 OTO - NOTNLM OT - adolescents OT - digital health literacy OT - disordered eating OT - physical activity OT - problematic social media use COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 06:24 PHST- 2026/07/14 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 06:24 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1937781 [doi] PST - epublish SO - Front Psychiatry. 2026 Aug 19;17:1937781. doi: 10.3389/fpsyt.2026.1937781. eCollection 2026. PMID- 42687936 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2813-2890 (Electronic) IS - 2813-2890 (Linking) VI - 5 DP - 2026 TI - Exploring nightly variability in sleep apnea and changes in severity classification with multi night sleep testing in a population based cohort of young children. PG - 1903809 LID - 10.3389/frsle.2026.1903809 [doi] LID - 1903809 AB - BACKGROUND: Obstructive sleep apnea (OSA) is typically evaluated with single-night sleep studies. In adults, night-to-night variability (NtNV) is well documented, but less so in children. The current study evaluated NtNV in apnea events for misclassification in disease severity in young children to investigate if multi-night sleep-recordings may be clinically relevant to improve diagnostic accuracy and affect treatment decisions. METHODS: Parents/guardians of healthy 4-9-year-old children participating in a study to evaluate prevalence of OSA were asked to record the child's sleep for up to 5-nights. This analysis is from children who completed three consecutive night sleep recordings. RESULTS: Average age of participants was 6.1 years (n = 200, 58.0%-girls/42.0%-boys), prevalence of overweight/obesity was 25% and moderate-severe-OSA (AHI(3%) >/= 5) based on single-night testing protocol was 29.0%. Using the highest AHI(3%) value from the three recordings, the first-night correctly identified 57.0% of participants and adding a second night identified 86.0% of participants, with 14% of participants not identified until the third night of sleep testing.Bland-Altman plots (BA(plots)) demonstrated non-statistically significant mean-differences and 95% upper and lower-limits (LOA(95%)) close in absolute terms night-one/night-two; -0.024 events/hour-of-sleep LOA(95%) [-5.062, 5.013], 8.0% of observations outside the LOA(95%) (p = 0.894) and night-two/night-three; -0.009 events/hour of sleep, LOA(95%) [-5.227, 5.209] and 6.0% of observations outside LOA(95%), (p = 0.9620).The intra-class correlation coefficient (ICC) for AHI(3%) for all 3 nights was 0.45 [0.37, 0.54], p < 0.001, for night-one/night-two (0.44; p < 0.001), and night-two/night-three (0.44; p < 0.001). Cohens Kappa (0.304-0.462) and Brennan-Prediger Kappa (0.403-0.490), respectively indicated low-to-moderate interrater agreement, with quadratic-weighted Cohen's Kappa for the four ordinal severity categories of 0.37 and 0.48 for the two night-pairs, demonstrating NtNV, which is consistent with the variability demonstrated by the BA(plots). CONCLUSION: Observed NtNV in apnea events affected severity categorization, suggesting that multi-night sleep testing may have clinical value and improve accuracy of sleep apnea evaluation in young children. CLINICAL TRIAL REGISTRATION: URL: clinicaltrials.gov/study/NCT05479201, identifier NCT0547920 . CI - Copyright (c) 2026 Magnusdottir, Ingolfsdottir, Hilmisson, Hrolfsdottir, Birkisson, Hallgrimsdottir, Johannesdottir and Petersen. FAU - Magnusdottir, Solveig AU - Magnusdottir S AD - MyCardio LLC, Denver, CO, United States. FAU - Ingolfsdottir, Ingibjorg AU - Ingolfsdottir I AD - Akureyri Hospital, Pediatrics, Akureyri, Iceland. AD - University of Iceland, Reykjavik, Iceland. FAU - Hilmisson, Hugi AU - Hilmisson H AD - MyCardio LLC, Denver, CO, United States. FAU - Hrolfsdottir, Laufey AU - Hrolfsdottir L AD - Institution of Health Science Research, University of Akureyri and Akureyri Hospital, Akureyri, Iceland. FAU - Birkisson, Magnus AU - Birkisson M AD - Akureyri Hospital, Ear Nose Throat, Akureyri, Iceland. FAU - Hallgrimsdottir, Erla AU - Hallgrimsdottir E AD - Aarhus University, Aarhus, Denmark. FAU - Johannesdottir, Groa AU - Johannesdottir G AD - Akureyri Hospital, Pediatrics, Akureyri, Iceland. FAU - Petersen, Hannes AU - Petersen H AD - University of Iceland, Reykjavik, Iceland. AD - Akureyri Hospital, Ear Nose Throat, Akureyri, Iceland. LA - eng SI - ClinicalTrials.gov/NCT05479201 PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Sleep JT - Frontiers in sleep JID - 9918451286706676 PMC - PMC13533644 OTO - NOTNLM OT - apnea hypopnea index OT - children OT - diagnostic accuracy OT - night-to-night variability OT - sleep apnea COIS- SM was employed by MyCardio LLC. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author HP declared being an editorial board member of Vestibular Disorders, Frontiers in Audiology and Otology, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 05:18 PHST- 2026/06/08 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 05:18 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/frsle.2026.1903809 [doi] PST - epublish SO - Front Sleep. 2026 Aug 19;5:1903809. doi: 10.3389/frsle.2026.1903809. eCollection 2026. PMID- 42687173 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Aug 13 TI - Population-adapted Nolla method for dental age estimation in Northwestern Romanian children. LID - 10.1186/s12903-026-09588-6 [doi] LID - 1654 AB - OBJECTIVES: Accurate dental age (DA) estimation is essential in pediatric dentistry, orthodontic treatment planning, and forensic practice; however, the applicability of international reference standards varies across populations. This study aimed to evaluate the accuracy of a population-adapted Nolla method for dental age estimation in children from northwestern Romania and to compare its performance with the original approach. MATERIALS AND METHODS: A retrospective analysis was performed on 860 digital panoramic radiographs of children aged 3-15 years. Dental development was assessed using the Nolla staging system, and a third-degree polynomial regression model was developed to estimate chronological age (CA) based on the total Nolla score. Model performance was evaluated using coefficient of determination (R(2)), five-fold cross-validation, and non-parametric statistical tests. RESULTS: The original Nolla method underestimated CA by approximately 1.5 years. The population-specific model showed strong predictive performance (R(2) = 0.846; cross-validated R(2) = 0.84) and close agreement between estimated DA and CA (mean difference 0.000 +/- 0.976 years; p = 0.983). Accuracy was stable across most age groups, although larger deviations were observed after 12 years. Girls showed slightly more advanced dental maturation than boys, but differences were clinically small. CONCLUSIONS: The proposed population-calibrated equation eliminates systematic bias and provides a reliable tool for dental age estimation in children from northwestern Romania, although external validation is recommended. CI - (c) 2026. The Author(s). FAU - Moga, Ligia Ioana AU - Moga LI AD - Doctoral School of Biomedical Sciences, University of Oradea, Oradea, Romania. FAU - Iurcov, Raluca AU - Iurcov R AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. FAU - Moca, Abel Emanuel AU - Moca AE AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. abelmoca@uoradea.ro. FAU - Csep, Andrei AU - Csep A AD - Department of Psycho-Neurosciences and Recovery, University of Oradea, Oradea, Romania. csep.andrei@gmail.com. FAU - Slavescu, Dan AU - Slavescu D AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. FAU - Dima, Raluca AU - Dima R AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. FAU - Vaida, Ligia Luminita AU - Vaida LL AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260813 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Romania MH - Child MH - Child, Preschool MH - Retrospective Studies MH - Radiography, Panoramic MH - Female MH - Male MH - Adolescent MH - Reproducibility of Results PMC - PMC13536641 OTO - NOTNLM OT - Dental age estimation OT - Dental maturation OT - Nolla method OT - Romanian children COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the ethical principles of the Declaration of Helsinki (1964) and its subsequent amendments. Ethical approval was obtained from the Research Ethics Committee of the Faculty of Medicine and Pharmacy, University of Oradea (Approval No. CEFMF/1, issued on 30 July 2024). Written informed consent was obtained from the parents or legal guardians for the use of anonymized radiographic data for research purposes. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/03 05:37 MHDA- 2026/09/03 05:38 PMCR- 2026/08/13 CRDT- 2026/09/03 02:01 PHST- 2026/03/10 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/09/03 05:38 [medline] PHST- 2026/09/03 05:37 [pubmed] PHST- 2026/09/03 02:01 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.1186/s12903-026-09588-6 [pii] AID - 9588 [pii] AID - 10.1186/s12903-026-09588-6 [doi] PST - epublish SO - BMC Oral Health. 2026 Aug 13;26(1):1654. doi: 10.1186/s12903-026-09588-6. PMID- 42686933 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260912 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Sep 3 TI - Complete blood count-derived inflammatory biomarkers and neonatal cholestasis in preterm infants: a matched case-control study. LID - 713 [pii] LID - 10.1007/s00431-026-07387-3 [doi] AB - Inflammation has been implicated in neonatal cholestasis, but associations between complete blood count (CBC)-derived inflammatory biomarkers and cholestasis remain unclear. This study evaluated these associations in preterm infants. This retrospective 1:1 matched case-control study included 284 cholestatic cases and 284 matched controls. Eight biomarkers were evaluated: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), neutrophil-plus-monocyte-to-lymphocyte ratio (NMLR), systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), neutrophil-to-lymphocyte-to-platelet ratio (NLPR), and prognostic nutritional index (PNI). Conditional logistic regression, restricted cubic spline, subgroup, interaction, and sensitivity analyses were performed. In fully adjusted models, higher levels of NLPR, NLR, NMLR, PNI, and SIRI remained associated with an increased risk of cholestasis, whereas PLR was inversely associated with cholestasis risk. Specifically, each unit increase in NLR, NMLR, and SIRI was associated with a 28% (OR = 1.28, 95% CI: 1.07-1.53), 23% (OR = 1.23, 95% CI: 1.05-1.44), and 8% (OR = 1.08, 95% CI: 1.01-1.16) increase in cholestasis risk, respectively, whereas higher PLR was associated with a lower risk of cholestasis (OR = 0.99, 95% CI: 0.99-1.00). Tertile analyses showed higher odds of cholestasis in the highest NLPR tertile and lower odds in the higher PLR tertiles. Compared with the lowest tertile, infants in the highest tertile had a 2.19-fold higher risk of cholestasis for NLPR (OR = 2.19, 95% CI: 1.34-3.58). Conversely, higher tertiles of platelet-to-lymphocyte ratio (PLR) were associated with a reduced risk of cholestasis, with infants in the highest tertile showing significantly lower odds than those in the lowest tertile (T3 vs. T1: OR = 0.44, 95% CI: 0.27-0.72). Restricted cubic spline analyses revealed that PLR exhibited a L-shaped relationship with cholestasis risk. Subgroup and interaction analyses suggested that the observed associations were generally robust across clinical subgroups. CONCLUSION: Several routinely available CBC-derived inflammatory biomarkers were associated with neonatal cholestasis in preterm infants. These findings are associational and require prospective validation before the biomarkers can be used for prediction or clinical decision-making. WHAT IS KNOWN: * Systemic inflammation has been hypothesized to be involved in neonatal cholestasis, but its contribution to the development of cholestasis in preterm infants remains insufficiently established. * Evidence regarding the associations between complete blood count-derived inflammatory biomarkers and neonatal cholestasis is limited. WHAT IS NEW: * Higher NLPR, NLR, NMLR, PNI, and SIRI levels were associated with higher odds of neonatal cholestasis, whereas PLR showed an inverse association. * These findings provide epidemiological support for the hypothesis that systemic inflammation may be involved in neonatal cholestasis, although causality cannot be established. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Li, Xueying AU - Li X AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. FAU - Liu, Yang AU - Liu Y AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. FAU - Yang, Xia AU - Yang X AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. FAU - Kong, Yanan AU - Kong Y AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. FAU - Zhou, Qi AU - Zhou Q AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. zhou_qi@jlu.edu.cn. LA - eng PT - Journal Article DEP - 20260903 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Cholestasis/blood/diagnosis/etiology MH - Infant, Newborn MH - Biomarkers/blood MH - Case-Control Studies MH - Male MH - Female MH - Retrospective Studies MH - Infant, Premature MH - Blood Cell Count MH - *Inflammation/blood MH - Neutrophils MH - *Infant, Premature, Diseases/blood/diagnosis MH - Logistic Models OTO - NOTNLM OT - Case-control study OT - Inflammatory biomarkers OT - Neonatal cholestasis OT - Preterm infants COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the First Hospital of Jilin University (No. AF-IRB-032-07). The requirement for informed consent was waived by the Ethics Committee of the First Hospital of Jilin University because of the retrospective study design and the use of anonymized clinical data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/03 05:36 MHDA- 2026/09/03 05:37 CRDT- 2026/09/03 01:08 PHST- 2026/07/07 00:00 [received] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/08/17 00:00 [revised] PHST- 2026/09/03 05:37 [medline] PHST- 2026/09/03 05:36 [pubmed] PHST- 2026/09/03 01:08 [entrez] AID - 10.1007/s00431-026-07387-3 [pii] AID - 10.1007/s00431-026-07387-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Sep 3;185(9):713. doi: 10.1007/s00431-026-07387-3. PMID- 42685093 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260905 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 9 DP - 2026 TI - Effect of school health nurse-supported child-to-family strategy for Diabetic Retinopathy prevention in Bhimeshwor Municipality of Bagmati Province, Nepal: A quasi-experimental study. PG - e0357023 LID - 10.1371/journal.pone.0357023 [doi] LID - e0357023 AB - INTRODUCTION: Diabetic retinopathy (DR) is a leading cause of vision loss among individuals with diabetes, with prevention depending heavily on awareness and timely action. This study assesses the effectiveness of a school health nurse-supported child-to-family strategy for diabetic retinopathy prevention in Bhimeshwor Municipality, Nepal, focusing on students' knowledge, family members' knowledge and practices, and students' retention in promoting health. METHODS: A quasi-experimental pre-test-post-test control group design was conducted in purposively selected government schools with grades 7 and 8 that had school health nurse. One school was assigned as an intervention site and two schools as controls. A total of 140 students (70 intervention, 70 control) were selected using proportionate random sampling, each paired with a co-residing family member aged >/=30 years. The intervention included a six-week school nurse-led education program followed by student-led sessions at home. Quantitative data were collected using self-administered semi-structured questionnaires for students and face-to-face interviews for family members and analyzed using descriptive and non-parametric tests. Qualitative data was gathered through focus group discussions (one with students and one with family members) and a key informant interview with the school health nurse. RESULTS: Post-intervention, students in the intervention group showed a significant increase in DR knowledge (median score: 0-16, p < 0.001), with large effect sizes (0.853) for knowledge and skills. Among family members, the intervention group demonstrated significant improvements in knowledge (median: 0-10, p < 0.001), attitude, perceived behavioral control, subjective norms, perceived severity, and self-efficacy (all p < 0.001), However, no significant change was observed in DR preventive practices, including regular eye check-ups, health tests (blood sugar and blood pressure), balanced diet and physical activity (p = 0.875). Qualitative findings supported the quantitative results, highlighting improved awareness, behavioral intentions, and family-level engagement. CONCLUSION: The intervention showed medium-to-high improvements in the experiential processes of diabetic-retinopathy prevention (knowledge, attitudes, subjective norms, perceived severity, perceived behavioral control and self-efficacy). However, behavioral change in actual preventive practices was not evident, likely due to the short intervention period. Approximately half of the students maintained high retention in sharing health information with their families. Strengthening experiential processes appears feasible, but further research with longer follow-up is needed to promote sustained behavioral change in diabetic-retinopathy preventive practices. TRIAL REGISTRATION: The study trial was registered in the Australian New Zealand Clinical Trials Registry (ANZCTR). The trial registration number is ACTRN12625000560493 on 02/06/2025. CI - Copyright: (c) 2026 Shrestha et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Shrestha, Ramesh AU - Shrestha R AUID- ORCID: 0000-0002-9038-6378 AD - School of Health and Allied Sciences, Pokhara University, Pokhara, Nepal. FAU - Adhikari, Chiranjivi AU - Adhikari C AUID- ORCID: 0000-0002-4706-2183 AD - School of Health and Allied Sciences, Pokhara University, Pokhara, Nepal. FAU - Shrestha, Mohan Krishna AU - Shrestha MK AD - Tilganga Institute of Ophthalmology, Kathmandu, Nepal. FAU - Paneru, Damaru Prasad AU - Paneru DP AD - School of Health and Allied Sciences, Pokhara University, Pokhara, Nepal. FAU - Dawadi, Amar AU - Dawadi A AD - School of Health and Allied Sciences, Pokhara University, Pokhara, Nepal. FAU - D C, Uma AU - D C U AD - School of Health and Allied Sciences, Pokhara University, Pokhara, Nepal. LA - eng PT - Journal Article DEP - 20260902 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Diabetic Retinopathy/prevention & control MH - Nepal MH - Female MH - Male MH - Health Knowledge, Attitudes, Practice MH - *School Nursing/methods MH - Child MH - Adult MH - *School Health Services MH - Family MH - Surveys and Questionnaires PMC - PMC13537593 COIS- Authors declare no conflict of interest exist. EDAT- 2026/09/03 01:13 MHDA- 2026/09/03 01:14 PMCR- 2026/09/02 CRDT- 2026/09/02 13:44 PHST- 2025/07/01 00:00 [received] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/09/03 01:14 [medline] PHST- 2026/09/03 01:13 [pubmed] PHST- 2026/09/02 13:44 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - PONE-D-25-30744 [pii] AID - 10.1371/journal.pone.0357023 [doi] PST - epublish SO - PLoS One. 2026 Sep 2;21(9):e0357023. doi: 10.1371/journal.pone.0357023. eCollection 2026. PMID- 42685060 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260902 LR - 20260905 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 9 DP - 2026 TI - Adolescent-led Our Voice method to promote healthy and active lifestyles and environments in South Africa. PG - e0007141 LID - 10.1371/journal.pgph.0007141 [doi] LID - e0007141 AB - Adolescents' immediate environments, including their homes, schools, and neighbourhoods, have a significant impact on their behaviour, health and development. Fostering adolescents' agency and empowerment can drive environmental and behavioural changes that can lead to improved health outcomes and reduced disparities in current and future generations. The objective of the study was to pilot and evaluate the implementation of a "by the people" citizen science method (the Our Voice method), engaging adolescent high school learners in Cape Town, Western Cape, South Africa in promoting healthy and active lifestyles and environments. Sixty-six high school adolescents of both genders between the ages of 13-18 years old were purposively recruited from 6 high schools in Cape Town, located in places of low or middle/high socioeconomic areas (SEA), as citizen scientists. The citizen scientists and some caregivers were interviewed via telephone. Citizen scientists also used a mobile application to collect data in their immediate environments to identify barriers to healthy eating, physical activity, hygiene, and safety. Data were audio-recorded, downloaded, and transcribed. In facilitated workshops, citizen scientists analysed the data and proffered solutions to the barriers, advocated change, and thereafter implemented relevant health promoting changes. Demographic characteristics and anthropometric measurements of the adolescents were also collected. Overall, similar barriers were experienced by adolescents regardless of SEA. However, lower socioeconomic status areas were a significant contributor of barriers to physical inactivity and unhealthy eating, safety, and hygiene. The buy-in and participation of adolescents and the school authority in the intervention to promote healthy lifestyles and environments is imperative. The Our Voice method was found to be a promising multi-layered tool for empowering adolescents as advocates in promoting feasible healthy and active lifestyle and environmental changes. CI - Copyright: (c) 2026 Wayas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Wayas, Feyisayo A AU - Wayas FA AUID- ORCID: 0000-0002-0966-3834 AD - Research Centre for Health through Physical Activity, Lifestyle & Sport, Division of Physiological Sciences, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. AD - IMS Epidemiology, Institute of Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom. FAU - Matwa, Namhla AU - Matwa N AD - Department of Sport Management, Centre for Sport Business and Technology Research (CSBTR), Cape Peninsula University of Technology, Cape Town, South Africa. FAU - West, Sacha AU - West S AUID- ORCID: 0000-0001-8770-995X AD - Department of Sport Management, Centre for Sport Business and Technology Research (CSBTR), Cape Peninsula University of Technology, Cape Town, South Africa. FAU - King, Abby C AU - King AC AUID- ORCID: 0000-0002-7949-8811 AD - Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, California, United States of America. AD - Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California, United States of America. FAU - Oni, Tolu AU - Oni T AD - IMS Epidemiology, Institute of Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom. FAU - Lambert, Estelle V AU - Lambert EV AUID- ORCID: 0000-0003-4315-9153 AD - Research Centre for Health through Physical Activity, Lifestyle & Sport, Division of Physiological Sciences, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. AD - School of Health, Psychological and Medical Sciences, and Institute for Health Research, University of Southern Queensland, Ipswich, Queensland, Australia. AD - Department of Human Kinetics and Ergonomics, Rhodes University, Makhanda, South Africa. LA - eng GR - D43 TW010540/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20260902 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC13537583 COIS- The authors have declared that no competing interests exist. EDAT- 2026/09/03 01:13 MHDA- 2026/09/03 01:14 PMCR- 2026/09/02 CRDT- 2026/09/02 13:43 PHST- 2025/12/18 00:00 [received] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/03 01:14 [medline] PHST- 2026/09/03 01:13 [pubmed] PHST- 2026/09/02 13:43 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - PGPH-D-25-03964 [pii] AID - 10.1371/journal.pgph.0007141 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Sep 2;6(9):e0007141. doi: 10.1371/journal.pgph.0007141. eCollection 2026. PMID- 42684799 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260919 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Sep 2 TI - A Digital Registry and Education Network for Child Maltreatment Protection: Protocol for a Pilot Observational Exploratory Intervention Study. PG - e89128 LID - 10.2196/89128 [doi] LID - e89128 AB - BACKGROUND: Child maltreatment, a major public health concern, has long-term neurobiological, psychological, and social consequences. Recognizing, documenting, and reporting suspected cases should be systematic across hospital and community services, but these processes are hindered by inconsistent surveillance systems, uneven professional training, and the lack of standardized data collection tools. Timely follow-up, updated clinical criteria, and structured multidisciplinary training can improve case assessment, traceability, and professionals' ability to report suspected maltreatment. The Sentinel project was developed to address these clinical, organizational, and public health gaps through a combined REDCap-based digital registry and structured training program for pediatric health care professionals. OBJECTIVE: This study aims to evaluate the usability, feasibility, and preliminary impact of an integrated surveillance and training system designed to improve the early detection, documentation, and reporting of suspected child maltreatment by pediatricians and health care professionals. METHODS: This is an observational, exploratory, monocentric pilot implementation study with a pretest-posttest evaluation design. The study will be conducted over 24 months in a hospital-community pediatric network. Voluntary participants will be hospital and community pediatricians and other pediatric health care professionals who provide written informed consent. The project includes two interconnected components: (1) implementation of a secure, anonymized REDCap registry for standardized documentation of suspected maltreatment, follow-up, reporting pathways, and case management outcomes and (2) a theoretical-practical training program delivered through lectures, e-learning modules, webinars, supervised exercises, and hands-on registry sessions. Primary and secondary outcomes will be assessed at prespecified time points, including baseline, immediately after training, during registry use, and at the end of follow-up. Registry usability will be measured using the System Usability Scale; training effectiveness will be measured through pretest-posttest knowledge, competency tests, and satisfaction questionnaires; and reporting outcomes will be measured through comparison of pre- and postimplementation reporting rates. RESULTS: The study will report the usability, feasibility, and preliminary implementation outcomes of the integrated registry training system. Main results will include System Usability Scale scores, registry completion indicators, reporting timeliness, the number and rate of suspected maltreatment reports before and after implementation, changes in knowledge and competency scores, participant satisfaction, and qualitative feedback on barriers to and facilitators of implementation. Participant recruitment and data collection began in April 2026 and are currently ongoing. Completion of data collection and publication of the results are expected between December 2027 and January 2028. CONCLUSIONS: The Sentinel project will test an innovative and scalable pilot model that integrates digital surveillance with structured professional training to enhance the early detection, documentation, and management of suspected child maltreatment. By standardizing data collection, strengthening professional competencies, and fostering collaboration across hospital and community settings, the study will inform the development of a regional or national observatory and support an evidence-based, system-wide approach to child protection. TRIAL REGISTRATION: ClinicalTrials.gov NCT07250074; https://clinicaltrials.gov/study/NCT07250074. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/89128. CI - (c)Gianvincenzo Zuccotti, Dario Dilillo, Antonella Agosto, Valeria Brazzoduro, Eloisa Brunilde Lina Marinelli, Valeria Calcaterra. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 02.09.2026. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AUID- ORCID: 0000-0002-2795-9874 AD - Department of Biomedical and Clinical Sciences, University of Milan, Milano, Lombardy, Italy. AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. FAU - Dilillo, Dario AU - Dilillo D AUID- ORCID: 0000-0002-5978-6146 AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. FAU - Agosto, Antonella AU - Agosto A AUID- ORCID: 0009-0000-0917-2261 AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. FAU - Brazzoduro, Valeria AU - Brazzoduro V AUID- ORCID: 0009-0003-4270-0611 AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. FAU - Marinelli, Eloisa Brunilde Lina AU - Marinelli EBL AUID- ORCID: 0009-0001-9259-0962 AD - Azienda Socio-Sanitaria Territoriale Fatebenefratelli Sacco, Milano, Lombardy, Italy. FAU - Calcaterra, Valeria AU - Calcaterra V AUID- ORCID: 0000-0002-2137-5974 AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. AD - Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Lombardy, Italy. LA - eng SI - ClinicalTrials.gov/NCT07250074 PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20260902 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Child Abuse/prevention & control/diagnosis MH - *Registries/statistics & numerical data MH - Pilot Projects MH - Child MH - Research Design PMC - PMC13583510 OTO - NOTNLM OT - child maltreatment OT - children OT - digital registry OT - education network OT - protection COIS- Conflicts of Interest: None declared. EDAT- 2026/09/03 01:13 MHDA- 2026/09/03 01:14 PMCR- 2026/09/02 CRDT- 2026/09/02 12:04 PHST- 2025/12/07 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/13 00:00 [revised] PHST- 2026/09/03 01:14 [medline] PHST- 2026/09/03 01:13 [pubmed] PHST- 2026/09/02 12:04 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - v15i1e89128 [pii] AID - 10.2196/89128 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Sep 2;15:e89128. doi: 10.2196/89128. PMID- 42684739 OWN - NLM STAT- Publisher LR - 20260902 IS - 1939-3229 (Electronic) IS - 1939-3210 (Linking) DP - 2026 Sep 2 TI - Organochlorine pesticide residues in cow's milk, honey, and poultry eggs in Algiers, Algeria, and associated health risk. PG - 1-13 LID - 10.1080/19393210.2026.2714426 [doi] AB - Organochlorine pesticide residues were determined in 180 animal-derived food samples (cow's milk, honey, and poultry eggs) from three zones in Algiers (Rouiba, Zeralda, and Beraki) to evaluate their chronic non-carcinogenic health risks. Method validation using GC-MS demonstrated high precision and linearity (R(2) > 0.995), satisfactory recovery rates (76.9-91.4%) and LOQs of 0.001-0.009 microg/kg. Analysis revealed a pronounced geographic profile, positioning Beraki as a major environmental hotspot, with mean levels up to 15.18 microg/kg for endrin in milk, 11.44 microg/kg for gamma-BHC in honey, and 39.46 microg/kg for gamma-BHC in eggs. While dietary intake from Rouiba and Zeralda proved to be toxicologically safe, the cumulative hazard indices (HIs) for infants consuming Beraki-sourced milk (HI = 1.19) and honey (HI = 1.55) exceeded the threshold of 1. Conversely, poultry egg consumption was considered to be safe across all regions (HI < 1). These findings highlight a localised public health concern for the local population in Beraki. FAU - Chebli, Akli Islem AU - Chebli AI AUID- ORCID: 0000-0001-9242-9733 AD - Department of Pharmacy, Faculty of Pharmacy, University of Medical Sciences, Algiers, Algeria. AD - Research and Development Department, National Center of Toxicology, Algiers, Algeria. FAU - Iko Afe, O Herbert AU - Iko Afe OH AD - Department of Nutrition, Food Sciences and Technology, Faculty of Agronomic Sciences, University of Abomey-Calavi, Cotonou, Benin. FAU - Uc-Peraza, Russell Giovanni AU - Uc-Peraza RG AUID- ORCID: 0000-0003-4014-3172 AD - Division de Ciencias, Ingenieria Y Tecnologia, Universidad Autonoma Del Estado de Quintana Roo (UAEQROO), Chetumal, Mexico. FAU - Kindossi, Janvier Melegnonfan AU - Kindossi JM AD - Laboratory of Applied Modelling in Nutrition and Food Sciences, Department of Nutrition and Food Sciences, Faculty of Agronomy, University of Parakou, Algiers, Benin. FAU - Fassinou, Grace L Setondji AU - Fassinou GLS AD - Laboratory of Human Nutrition and Valorization of Food Bio-Ingredients, Faculty of Agricultural Sciences, University of Abomey-Calavi, Jericho Cotonou, Benin. FAU - Mehouel, Fetta AU - Mehouel F AUID- ORCID: 0000-0001-9771-2183 AD - Laboratory of Research Food Hygiene and Quality Insurance System (HASAQ), Institute of Veterinary Sciences, University of Constantine 1, Constantine, Algeria. AD - Department of Veterinary Sciences, Higher National Veterinary School of Algiers (ENSV- Alger), Algiers, Algeria. FAU - Zergui, Anissa AU - Zergui A AUID- ORCID: 0000-0001-8074-4082 AD - Department of Pharmacy, Faculty of Medicine, University of Oran, Oran, Algeria. FAU - Amziane, Ahmed AU - Amziane A AD - Department of Pharmacy, Faculty of Pharmacy, University of Medical Sciences, Algiers, Algeria. AD - Research and Development Department, National Center of Toxicology, Algiers, Algeria. FAU - Abdennour, Sara AU - Abdennour S AD - Department of Pharmacy, Faculty of Medicine, University of Setif 1, Setif, Algeria. FAU - Zebbiche, Younes AU - Zebbiche Y AUID- ORCID: 0000-0002-1427-8025 AD - Department of Pharmacy, Faculty of Pharmacy, University of Medical Sciences, Algiers, Algeria. LA - eng PT - Journal Article DEP - 20260902 PL - England TA - Food Addit Contam Part B Surveill JT - Food additives & contaminants. Part B, Surveillance JID - 101317183 SB - IM OTO - NOTNLM OT - Algeria OT - Organochlorine pesticides OT - animal-derived food OT - cow's milk OT - health risk assessment OT - honey OT - poultry eggs EDAT- 2026/09/03 01:13 MHDA- 2026/09/03 01:13 CRDT- 2026/09/02 12:01 PHST- 2026/09/03 01:13 [medline] PHST- 2026/09/03 01:13 [pubmed] PHST- 2026/09/02 12:01 [entrez] AID - 10.1080/19393210.2026.2714426 [doi] PST - aheadofprint SO - Food Addit Contam Part B Surveill. 2026 Sep 2:1-13. doi: 10.1080/19393210.2026.2714426. PMID- 42684076 OWN - NLM STAT- Publisher LR - 20260902 IS - 1541-3144 (Electronic) IS - 0194-2638 (Linking) DP - 2026 Sep 2 TI - Engagement of Children with Moderate and High Support Needs Autism in Motor Program Sessions. PG - 1-19 LID - 10.1080/01942638.2026.2722992 [doi] AB - AIMS: This study examined engagement during one-on-one motor program sessions for children with moderate and high support needs (MHS) autism by: (1) systematically coding child behaviors as on-task or off-task, and (2) exploring therapist-reported strategies to facilitate engagement. METHODS: Nine children (4-10 years) with MHS autism participated in a 13 week, twice-weekly motor program. All sessions were video recorded. A bespoke observational coding system was developed to measure gross motor skill practice, achieving interrater reliability (ICC = 0.927). A stratified sample of 27 sessions was coded. Eleven exercise physiologists completed semi-structured interviews at two timepoints, analyzed using reflexive thematic analysis. RESULTS: Children spent an average of 29.6% of session time in motor skill practice. Off-task periods involved sensory-seeking, co-regulation, avoidance, and exploratory or social behaviors. Interview analysis identified one overarching theme-attuning to the child-with subthemes describing the importance of the therapeutic relationship and prioritizing the child's needs. Sessions were adapted according to each child's cues, communication style, and regulatory needs. CONCLUSIONS: Findings highlight the central role of relational and regulatory processes in supporting engagement for children with MHS autism and emphasize the need for further research on mechanisms of change and therapists' moment-to-moment decision-making. FAU - Svensson, Lee AU - Svensson L AUID- ORCID: 0000-0001-5971-783X AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. AD - Health and Wellbeing Centre for Research Innovation, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Stylianou, Michalis AU - Stylianou M AUID- ORCID: 0000-0002-5905-8229 AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Hill, Jessica AU - Hill J AUID- ORCID: 0000-0003-2650-455X AD - School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Australia. FAU - Wilson, Lucille AU - Wilson L AUID- ORCID: 0000-0003-0993-7302 AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. AD - Health and Wellbeing Centre for Research Innovation, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Trost, Stewart G AU - Trost SG AUID- ORCID: 0000-0001-9587-3944 AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Cairney, John AU - Cairney J AUID- ORCID: 0000-0003-2856-3967 AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. AD - Health and Wellbeing Centre for Research Innovation, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. AD - Queensland Centre for Olympic and Paralympic Studies, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. LA - eng PT - Journal Article DEP - 20260902 PL - England TA - Phys Occup Ther Pediatr JT - Physical & occupational therapy in pediatrics JID - 8109120 SB - IM OTO - NOTNLM OT - Autism OT - children OT - engagement OT - motor skills OT - therapists EDAT- 2026/09/02 11:38 MHDA- 2026/09/02 11:38 CRDT- 2026/09/02 10:48 PHST- 2026/09/02 11:38 [medline] PHST- 2026/09/02 11:38 [pubmed] PHST- 2026/09/02 10:48 [entrez] AID - 10.1080/01942638.2026.2722992 [doi] PST - aheadofprint SO - Phys Occup Ther Pediatr. 2026 Sep 2:1-19. doi: 10.1080/01942638.2026.2722992. PMID- 42683142 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260902 LR - 20260903 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Quality Assessment of Complementary Feeding (CF) Practices Using CF Index and Determining Its Association With Sociodemographic Factors Among Children Aged 6-23 Months in District Etawah, Uttar Pradesh, India: A Community-Based Cross-Sectional Study. PG - e113808 LID - 10.7759/cureus.113808 [doi] LID - e113808 AB - BACKGROUND: Achieving nutritionally sufficient and well-timed supplementary feeding is central to sustaining physical growth, brain maturation, and immunological competence in infants and toddlers from 6 through 23 months. The Complementary Feeding Index (CFI) functions as an integrated multi-component instrument designed to quantify the overall adequacy of young child nutrition at the household level. OBJECTIVE: This investigation sought to appraise complementary feeding adequacy via the CFI and explore its associations with sociodemographic characteristics among children between 6 and 23 months of age in Etawah district, Uttar Pradesh, India. METHODS: This community-based cross-sectional analytical study recruited 416 children aged 6-23 months across rural and urban localities of Etawah district between January 2024 and February 2026. Household data were obtained through a validated, pre-piloted structured interview tool. CFI sub-indicators were evaluated: breastfeeding continuation, bottle use, age-appropriateness of complementary food introduction, dietary variety, food group coverage, and meal frequency. Anthropometric indices were measured with calibrated instruments, and all data were processed in Statistical Product and Service Solutions (SPSS, version 26.0; IBM SPSS Statistics for Windows, Armonk, NY). RESULTS: Breastfeeding was ongoing in 70.9% of children; 35.6% were bottle-fed. Supplementary foods at the recommended six-month milestone were given in 52.2% of cases. Minimum dietary diversity (MDD) was met by 22.1%, minimum meal frequency (MMF) by 59.4%, and minimum acceptable diet (MAD) by only 13.9%. Overall, CFI classification placed 43% of children in the appropriate and 57% in the inappropriate feeding category. CONCLUSION: Supplementary feeding quality in Etawah district is far below recommended thresholds, with 57% the children unable to achieve adequate dietary diversity or a MAD. Sustained investment in nutrition counselling, frontline workforce skill-building, and locally tailored community programmes is essential to reverse these deficits and improve child nutrition. CI - Copyright (c) 2026, Prajapati et al. FAU - Prajapati, Balram AU - Prajapati B AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Maurya, Adarsh AU - Maurya A AD - Community Medicine, Uma Nath Singh Autonomous State Medical College, Jaunpur, IND. FAU - Prajapati, Neelam AU - Prajapati N AD - Physical Medicine and Rehabilitation, King George's Medical University (KGMU), Lucknow, IND. FAU - Rani, Vidya AU - Rani V AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Singh, Naresh P AU - Singh NP AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Jain, Pankaj AU - Jain P AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Kaur, Gagan AU - Kaur G AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Shukla, Sushil AU - Shukla S AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. LA - eng PT - Journal Article DEP - 20260802 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13532554 OTO - NOTNLM OT - complementary feeding OT - complementary feeding index OT - dietary diversity OT - infant and young child feeding OT - malnutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, Uttar Pradesh University of Medical Sciences, Saifai, Etawah (U.P.) issued approval 45/Cert./ICE/UPUMS/2024-2025. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:40 PMCR- 2026/08/02 CRDT- 2026/09/02 09:01 PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/02 11:40 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 09:01 [entrez] PHST- 2026/08/02 00:00 [pmc-release] AID - 10.7759/cureus.113808 [doi] PST - epublish SO - Cureus. 2026 Aug 2;18(8):e113808. doi: 10.7759/cureus.113808. eCollection 2026 Aug. PMID- 42682778 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260902 LR - 20260903 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Exploring the impact of DEP on pediatric Crohn's disease using machine learning and molecular docking methods. PG - 1810586 LID - 10.3389/fped.2026.1810586 [doi] LID - 1810586 AB - BACKGROUND: Diethyl phthalate (DEP) is a prevalent plasticizer with multiple toxic effects and high bioavailability in humans, especially children. Pediatric Crohn's disease (PCD) is a severe chronic intestinal inflammatory disorder with a rising incidence worldwide. To date, the potential associative relationship between DEP exposure and PCD pathogenesis remains inadequately clarified, lacking systematic transcriptomic and experimental exploration. METHODS: In this study, bioinformatics analysis was performed based on 682 PCD samples and 127 normal samples retrieved from multiple GEO datasets. A series of analytical strategies including differential expression analysis, weighted gene co-expression network analysis (WGCNA), compound target prediction, functional enrichment analysis, machine learning modeling, and molecular docking simulation were comprehensively utilized, followed by preliminary animal validation. All analyses in this study focused on exploring statistical correlation rather than causal relationships, given the absence of individual DEP exposure data and inherent methodological limitations. RESULTS: Through differential analysis and WGCNA, 24 differentially expressed genes and 194 chemical targets from ChEMBL were obtained, among which 14 overlapping genes were identified. GO and KEGG analyses indicated that DEP may contribute to PCD toxicity by regulating nucleotide synthesis and amino acid metabolism. Five core genes were screened via machine learning and SHAP analysis. Animal experiments verified that PLAU protein expression in DEP, TNBS, and DEP + TNBS groups was notably higher than in the control colon tissue. CONCLUSION: This study systematically explores the potential associative links between DEP-related molecular dysregulation and PCD pathological alterations at the transcriptomic and tissue levels. The findings provide preliminary scientific references for understanding DEP-associated pediatric intestinal health risks and developing targeted preventive strategies for children's environmental health protection. CI - (c) 2026 Zhang, Ji, Ma and Chen. FAU - Zhang, Lei AU - Zhang L AD - Department of Gastroenterology, Donghai County People's Hospital, Lianyungang, China. FAU - Ji, Xingyu AU - Ji X AD - Department of Gastroenterology, Donghai County People's Hospital, Lianyungang, China. FAU - Ma, Su AU - Ma S AD - Department of Gastroenterology, The Third Affiliated Hospital of Dali University, Dali, China. FAU - Chen, Huimin AU - Chen H AD - Department of Gastroenterology, Donghai County People's Hospital, Lianyungang, China. LA - eng PT - Journal Article DEP - 20260818 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13529756 OTO - NOTNLM OT - Crohn's disease OT - diethyl phthalate OT - machine learning OT - molecular docking OT - pediatric COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:40 PMCR- 2026/08/18 CRDT- 2026/09/02 07:40 PHST- 2026/02/13 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/09/02 11:40 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 07:40 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.3389/fped.2026.1810586 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 18;14:1810586. doi: 10.3389/fped.2026.1810586. eCollection 2026. PMID- 42682592 OWN - NLM STAT- Publisher LR - 20260903 IS - 2574-2272 (Electronic) IS - 2096-3726 (Print) IS - 2574-2272 (Linking) DP - 2026 Aug 31 TI - The role of tryptophan hydroxylase-1 in metabolic dysfunction-associated steatotic liver disease. LID - 10.1002/ped4.70078 [doi] AB - IMPORTANCE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is caused by dysregulated lipid metabolism, inflammation, and mitochondrial dysfunction. Given the rising burden of MASLD in children and adolescents, identifying experimentally tractable mechanisms relevant to pediatric diseases is of considerable interest. Tryptophan hydroxylase-1 (TPH1), the rate-limiting enzyme for peripheral serotonin synthesis, has been implicated in metabolic disorders, but its hepatic role in MASLD remains unclear. OBJECTIVE: To investigate whether Tph1 suppression alleviates lipid accumulation, mitochondrial dysfunction, and hepatocyte injury through changes associated with Parkin-mediated mitophagy. METHODS: MASLD was induced in young adult male C57BL/6J mice by a 12-week high-fat diet (HFD). At HFD onset, mice received a single tail-vein injection of liver-tropic AAV8-shTph1 or the control AAV8. The HFD feeding was continued for 12 weeks until the end of the experiment. Hepatic histology, serum biochemistry, oxidative stress, inflammatory responses, apoptosis, and mitochondrial function were also evaluated. Mechanistic studies were conducted in palmitic acid/oleic acid-treated AML12 hepatocytes using siRNA targeting Tph1 and Parkin. RESULTS: Hepatic TPH1 expression was elevated in MASLD mice. Tph1 knockdown alleviated diet-induced steatosis, reduced serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, and transaminase levels, suppressed oxidative stress, and attenuated inflammatory and fibrotic markers. Tph1 silencing decreased hepatocyte apoptosis and restored mitochondrial function. Transmission electron microscopy and fractionated Western blotting analyses revealed increased Parkin-associated mitophagy. In AML12 cells, siTph1 reduced lipid accumulation and apoptosis, whereas co-silencing Parkin partially reversed these effects. INTERPRETATION: Hepatic TPH1 is associated with MASLD progression and impaired Parkin-mediated mitophagy. Tph1 suppression may represent a potential therapeutic strategy for experimental MASLD, with possible translational relevance to pediatric MASLD, though direct clinical validation is still needed. CI - (c) 2026 The Author(s). Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development. FAU - Jia, Shuangzhen AU - Jia S AUID- ORCID: 0000-0002-3163-7595 AD - Department of Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University National Center for Children's Health Beijing China. FAU - Ye, Xiaolin AU - Ye X AD - Department of Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University National Center for Children's Health Beijing China. FAU - Wang, Zhaoxia AU - Wang Z AD - Department of Gastroenterology Shenzhen Children's Hospital Shenzhen China. FAU - Wu, Jie AU - Wu J AD - Department of Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University National Center for Children's Health Beijing China. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - Pediatr Investig JT - Pediatric investigation JID - 101731527 PMC - PMC13529607 OTO - NOTNLM OT - Children OT - Metabolic dysfunction-associated steatotic liver disease (MASLD) OT - Parkin-dependent mitophagy OT - Tryptophan hydroxylase-1 (TPH1) COIS- The authors declare no conflict of interest. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:39 PMCR- 2026/08/31 CRDT- 2026/09/02 06:32 PHST- 2026/03/22 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/09/02 11:39 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 06:32 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - PED470078 [pii] AID - 10.1002/ped4.70078 [doi] PST - aheadofprint SO - Pediatr Investig. 2026 Aug 31:10.1002/ped4.70078. doi: 10.1002/ped4.70078. PMID- 42682444 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260902 LR - 20260903 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical activity relates to adolescent social anxiety: evidence from a structural equation model involving resilience and self-efficacy. PG - 1862222 LID - 10.3389/fpsyg.2026.1862222 [doi] LID - 1862222 AB - BACKGROUND: Physical activity is consistently associated with reduced anxiety in adolescents, yet the psychological mechanisms underlying this association remain unclear. This study examined whether resilience and self-efficacy independently and sequentially mediated the association between physical activity and social anxiety. METHODS: A cross-sectional design was used with 986 Chinese adolescents. Physical activity, resilience, self-efficacy, and social anxiety were assessed using validated scales (PARS-3, CD-RISC, GSES, and SASC). Structural equation modeling was conducted in R, and indirect effects were tested using bias-corrected bootstrap procedures with 5,000 resamples. RESULTS: Physical activity was significantly associated with lower social anxiety both directly (beta = -0.420, p < 0.001) and indirectly. The indirect association through resilience was significant [beta = -0.049, 95% CI [-0.064, -0.035]], whereas the indirect effect through self-efficacy and the serial mediation pathway were not significant. Absolute fit indices were acceptable (RMSEA = 0.064, SRMR = 0.073), but the incremental fit indices fell below conventional thresholds (CFI = 0.805, TLI = 0.796); the structural estimates should therefore be interpreted with corresponding caution. CONCLUSIONS: These findings are consistent with a model in which resilience functions as a proximal correlate linking physical activity to lower social anxiety, whereas general self-efficacy did not emerge as a significant mediator in this cross-sectional sample. Given the study design and the modest incremental fit of the model, these pathways should be read as theoretically plausible associations rather than causal effects. The results nonetheless underscore the potential value of fostering resilience within physical activity interventions, and they identify longitudinal designs and domain-specific efficacy measures as priorities for future research. CI - Copyright (c) 2026 Wang, Chen, Li, Yang, Chen, Shi, Lv and Lipowski. FAU - Wang, Ning AU - Wang N AD - Department of Physical Education, Lanzhou Institute of Technology, Lanzhou, Gansu, China. FAU - Chen, Ye AU - Chen Y AD - School of Business, China West Normal University, Nanchong, China. FAU - Li, Mengmeng AU - Li M AD - Chongqing Metropolitan College of Science and Technology, Chongqing, China. FAU - Yang, Jifan AU - Yang J AD - Jinding First Primary School, Zhuhai High tech Zone, Zhuhai, China. FAU - Chen, Fangting AU - Chen F AD - Jingyang Primary School, Zhuhai High tech Zone, Zhuhai, China. FAU - Shi, Yijie AU - Shi Y AD - Gdansk University of Physical Education and Sport, Gdansk, Poland. FAU - Lv, Rujun AU - Lv R AD - Zhongshan University Affiliated Houhuan Primary School in the High-tech Zone of Zhuhai City, Zhuhai, China. FAU - Lipowski, Mariusz AU - Lipowski M AD - WSB Merito University in Gdansk, Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260818 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13529522 OTO - NOTNLM OT - adolescents OT - physical activity OT - resilience OT - self-efficacy OT - social anxiety COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:40 PMCR- 2026/08/18 CRDT- 2026/09/02 05:23 PHST- 2026/04/22 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/09/02 11:40 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 05:23 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1862222 [doi] PST - epublish SO - Front Psychol. 2026 Aug 18;17:1862222. doi: 10.3389/fpsyg.2026.1862222. eCollection 2026. PMID- 42681656 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260923 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 24 IP - 1 DP - 2026 Aug 31 TI - Human milk microbiome as a modulator of the early-life gut-brain axis: mechanisms and translational opportunities for neurodevelopment. LID - 10.1186/s12967-026-08844-1 [doi] LID - 1125 AB - The first 1000 days of life represent a critical developmental window during which early microbial colonization contributes to immune, metabolic, and neurodevelopmental programming. Human milk is increasingly recognized as a biologically active fluid that shapes infant gut microbiome assembly through microorganisms, human milk oligosaccharides (HMOs), immune factors, and microbial metabolites. Within this framework, the human milk microbiome has emerged as a potential contributor to the milk-gut-brain axis (MGBA), a bidirectional communication network linking the gut microbiota with neural, immune, endocrine, and metabolic pathways involved in brain development. This review summarizes current evidence regarding the origins, determinants, and functional relevance of the human milk microbiome and its potential role in early-life neurodevelopment. Proposed microbial sources include maternal skin, the infant oral cavity, environmental exposure, and the entero-mammary pathway, while key determinants include lactational stage, delivery mode, antibiotic exposure, maternal diet, obesity, and prematurity. Mechanistic pathways linking milk-associated microbes with neurodevelopment are discussed, including microbial colonization, immune and barrier maturation, vagal and neuroendocrine signalling, and production of short-chain fatty acids (SCFAs) and tryptophan-derived metabolites. We further evaluate evidence relating breastfeeding and milk-associated microbial exposures to cognitive, behavioural, and neurodevelopmental outcomes, particularly in preterm and medically vulnerable infants. Although experimental and observational evidence supports biologically plausible links between the human milk microbiome and the developing microbiota-gut-brain axis, major uncertainties remain regarding microbial viability, sustained colonization, causality, and long-term functional significance. Methodological limitations, including low microbial biomass, contamination susceptibility, and heterogeneity in analytical approaches, continue to complicate interpretation across studies. Future progress will require longitudinal, mechanistically informed studies integrating microbiome profiling with metabolomics, immune phenotyping, neuroimaging, and validated neurodevelopmental outcomes. CI - (c) 2026. The Author(s). FAU - Alnuaimi, Fatima AU - Alnuaimi F AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Yassin, Lidya K AU - Yassin LK AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Alketbi, Salma AU - Alketbi S AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Skrabulyte-Barbulescu, Jurga AU - Skrabulyte-Barbulescu J AD - The Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King s College London, London, UK. FAU - Almazrouei, Saif AU - Almazrouei S AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Alremeithi, Dana AU - Alremeithi D AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Alahbabi, Noud AU - Alahbabi N AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Almarzooqi, Sultan AU - Almarzooqi S AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Alkuwaiti, Shamma H AU - Alkuwaiti SH AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Hamad, Mohammad I K AU - Hamad MIK AUID- ORCID: 0000-0002-7413-0305 AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. m.hamad@uaeu.ac.ae. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20260831 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 SB - IM EIN - J Transl Med. 2026 Sep 15;24(1):1184. doi: 10.1186/s12967-026-08990-6. PMID: 42745312 MH - Humans MH - *Milk, Human/microbiology MH - *Neurodevelopment MH - *Brain/growth & development MH - *Gastrointestinal Microbiome MH - *Translational Research, Biomedical MH - *Microbiota MH - Infant, Newborn MH - *Translational Science, Biomedical PMC - PMC13536827 OTO - NOTNLM OT - Breastfeeding OT - Human milk microbiome OT - Human milk oligosaccharides OT - Infant gut microbiota OT - Microbial metabolites OT - Milk-gut-brain axis OT - Neurodevelopment OT - Preterm infants COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interest. EDAT- 2026/09/02 05:36 MHDA- 2026/09/02 05:37 PMCR- 2026/08/31 CRDT- 2026/09/02 01:17 PHST- 2026/05/22 00:00 [received] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/02 05:37 [medline] PHST- 2026/09/02 05:36 [pubmed] PHST- 2026/09/02 01:17 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - 10.1186/s12967-026-08844-1 [pii] AID - 8844 [pii] AID - 10.1186/s12967-026-08844-1 [doi] PST - epublish SO - J Transl Med. 2026 Aug 31;24(1):1125. doi: 10.1186/s12967-026-08844-1. PMID- 42681548 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1541-4337 (Electronic) IS - 1541-4337 (Linking) VI - 25 IP - 5 DP - 2026 Sep TI - A Comprehensive Review of Fucosylated Human Milk Oligosaccharides: Biological Functions, Production Technologies, and Safety Regulation With Commercial Translation in Infant Nutrition. PG - e70636 LID - 10.1111/1541-4337.70636 [doi] LID - e70636 AB - Human milk oligosaccharides (HMOs) are important functional bioactive components of human milk. Fucosylated HMOs (FHMOs) represent a major subclass, accounting for approximately 35%-50% of total HMOs, and have attracted increasing attention in infant nutrition and health. Current evidence indicates that FHMOs play important roles in shaping the infant gut microbiota, modulating host-microbe interactions, supporting intestinal barrier function, and maintaining immune and metabolic homeostasis. However, their commercialization still faces several challenges, including high production costs, difficulties in the scalable manufacture of structurally complex members, uneven functional evidence across individual compounds, incomplete safety and regulatory evaluation frameworks, and the need to further validate processing stability and application performance in final products. From an industrial perspective, microbial fermentation has become the main production route for 2'-fucosyllactose and 3-fucosyllactose, whereas the large-scale production of more structurally complex or low-abundance FHMOs remains technically and economically challenging. Regulatory approvals in major markets indicate acceptable safety at authorized use levels, but uncertainties remain regarding long-term intake, vulnerable infant populations, matrix-dependent stability, and the combined use of multiple HMOs. This review summarizes recent advances in the structural characteristics, biological functions, production technologies, safety assessment, regulatory status, and commercial applications of FHMOs, with emphasis on 2'-fucosyllactose, 3-fucosyllactose, and selected structurally related members. It also discusses commercialization challenges and future research priorities to support their responsible application in infant nutrition. CI - (c) 2026 Institute of Food Technologists(R). FAU - Xu, Jinghong AU - Xu J AUID- ORCID: 0009-0000-8544-5794 AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Li, Bowen AU - Li B AUID- ORCID: 0000-0002-4199-7164 AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Xu, Huajian AU - Xu H AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Zhang, Qing AU - Zhang Q AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Li, Zheng AU - Li Z AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Zhong, Xiaocui AU - Zhong X AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Qiao, Dongling AU - Qiao D AUID- ORCID: 0000-0003-1831-422X AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Han, Ting-Li AU - Han TL AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhang, Binjia AU - Zhang B AUID- ORCID: 0009-0007-0104-571X AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. LA - eng GR - SWU-KQ25008/Fundamental Research Funds for the Central Universities/ GR - CSTB2024TIAD-KPX0014/Chongqing Technology Innovation and Application Development Special Key Project/ PT - Journal Article PT - Review PL - United States TA - Compr Rev Food Sci Food Saf JT - Comprehensive reviews in food science and food safety JID - 101305205 RN - 0 (Oligosaccharides) RN - 28RYY2IV3F (Fucose) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - *Oligosaccharides/chemistry MH - *Infant Nutritional Physiological Phenomena MH - Infant MH - Fermentation MH - Food Safety MH - Fucose/chemistry PMC - PMC13534321 OTO - NOTNLM OT - fucosylated glycans OT - human milk oligosaccharides OT - infant formula OT - microbial fermentation OT - regulatory science OT - safety assessment COIS- The authors declare no conflicts of interest. EDAT- 2026/09/02 05:36 MHDA- 2026/09/02 05:37 PMCR- 2026/09/02 CRDT- 2026/09/02 00:49 PHST- 2026/08/01 00:00 [revised] PHST- 2026/06/15 00:00 [received] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/02 05:37 [medline] PHST- 2026/09/02 05:36 [pubmed] PHST- 2026/09/02 00:49 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - CRF370636 [pii] AID - 10.1111/1541-4337.70636 [doi] PST - ppublish SO - Compr Rev Food Sci Food Saf. 2026 Sep;25(5):e70636. doi: 10.1111/1541-4337.70636. PMID- 42680256 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Low-burden metrics for monitoring healthy diets among nonpregnant females aged 15 to 49 years: a multicountry validation analysis using quantitative 24-hour dietary intake data. PG - 101387 LID - S0002-9165(26)00196-6 [pii] LID - 10.1016/j.ajcnut.2026.101387 [doi] AB - BACKGROUND: Limited nationally representative quantitative dietary intake data and a lack of consensus on lower-burden tools and metrics hinder high-frequency monitoring of healthy diets globally. OBJECTIVES: This study aimed to evaluate the comparative construct validity and potential complementarity of low-burden metrics of a healthy diet among nonpregnant females aged 15 to 49 y. METHODS: Quantitative 24-h dietary intake data collected from 77,118 adolescent and adult females across 27 countries were used to construct low-burden metrics and reference metrics of dietary intake. Associations between mean-standardized low-burden measures or indicators and reference metrics were assessed using linear and logistic mixed-effect models, with Spearman's rho used for survey-level rank correlations. Test characteristics identified low-burden indicators best differentiated adherence to reference indicators. RESULTS: An indicator reflecting nonconsumption of sweet foods and/or sweet beverages was most robustly associated with greater adherence to <10% energy from free sugars in upper-middle-income countries odds ratio [OR] [95% confidence interval (CI)]: 5.35 [5.05, 5.66]. Food group diversity score (FGDS) was most strongly associated with and differentiated higher mean adequacy ratio of micronutrients [beta of 1-standard deviation (SD) change: approximately 11 percentage points (9, 12); rho: 0.79], whereas noncommunicable disease-Protect score best reflected consumption of >/=400 g/d of fruits and vegetables [range OR of 1-SD changes (95% CI): 2.56-3.01 (2.40, 3.13) in lower-middle and high-income countries, respectively; rho: 0.56]. FGDS and Global Diet Quality Score Positive were most consistently associated with achieving >/=25 g/d of fiber and >/=3510 mg/d of potassium across contexts. CONCLUSIONS: Low-burden data collection tools yield valid metrics, enabling high-frequency monitoring of healthy diets across contexts. Specifically, avoiding sweet foods and/or sweet beverages is an indicator for adherence to WHO free sugar guidelines among nonpregnant females in upper-middle-income countries, whereas metrics reflecting nutritious food group diversity strongly reflect better micronutrient adequacy and adherence to WHO guidelines for fruits and vegetables, fiber, and potassium intakes within and across contexts. CI - Copyright (c) 2026 Food and Agriculture Organization of the United Nations,. Published by Elsevier Inc. All rights reserved. FAU - Hanley-Cook, Giles T AU - Hanley-Cook GT AD - Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. Electronic address: giles.hanleycook@fao.org. FAU - Frongillo, Edward A AU - Frongillo EA AD - Department of Health Promotion, Education, and Behaviour, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States. FAU - Sattamini, Isabela Fleury AU - Sattamini IF AD - Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FAU - Ingenbleek, Luc AU - Ingenbleek L AD - Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FAU - Coates, Jennifer C AU - Coates JC AD - The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Holmes, Bridget A AU - Holmes BA AD - Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. CN - Healthy Diets Monitoring Initiative (HDMI) LA - eng PT - Journal Article PT - Validation Study DEP - 20260813 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - *Diet, Healthy MH - Adolescent MH - Adult MH - Young Adult MH - Middle Aged MH - Energy Intake MH - Diet Surveys OTO - NOTNLM OT - GDQS OT - MDD-W OT - UPF OT - construct validity OT - dietary diversity OT - healthy diets OT - macronutrient balance OT - moderation OT - monitoring OT - nutrient adequacy COIS- Conflict of interest EF is a member of the Statistical Review Board of the American Society for Nutrition. The authors report no conflicts of interest. FIR - Aguayo, Victor IR - Aguayo V IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Branca, Francesco IR - Branca F IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Borghi, Elaine IR - Borghi E IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Coates, Jennifer C IR - Coates JC IRAD- The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FIR - Frongillo, Edward A IR - Frongillo EA IRAD- Department of Health Promotion, Education, and Behaviour, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States. FIR - Hanley-Cook, Giles T IR - Hanley-Cook GT IRAD- Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FIR - Hassfurter, Karoline IR - Hassfurter K IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Hayashi, Chika IR - Hayashi C IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Holmes, Bridget A IR - Holmes BA IRAD- Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FIR - Ingenbleek, Luc IR - Ingenbleek L IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Mehra, Vrinda IR - Mehra V IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Neufeld, Lynnette M IR - Neufeld LM IRAD- Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FIR - Saha, Kuntal IR - Saha K IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Sattamini, Isabella Fleury IR - Sattamini IF IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. EDAT- 2026/09/01 23:34 MHDA- 2026/09/01 23:35 CRDT- 2026/09/01 20:54 PHST- 2025/09/08 00:00 [received] PHST- 2026/04/14 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/09/01 23:35 [medline] PHST- 2026/09/01 23:34 [pubmed] PHST- 2026/09/01 20:54 [entrez] AID - S0002-9165(26)00196-6 [pii] AID - 10.1016/j.ajcnut.2026.101387 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101387. doi: 10.1016/j.ajcnut.2026.101387. Epub 2026 Aug 13. PMID- 42680155 OWN - NLM STAT- Publisher LR - 20260901 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) DP - 2026 Sep 1 TI - Validity of Nutrition Screening Tools for Risk of Malnutrition Among Pediatric Oncology Populations: A Systematic Review and Meta-Analysis. LID - nuag120 [pii] LID - 10.1093/nutrit/nuag120 [doi] AB - CONTEXT: The lack of standardized procedures for malnutrition risk screening in the pediatric oncology population. OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the validity of nutritional screening tools for identifying the risk of malnutrition in pediatric oncology patients. DATA SOURCES: A systematic review of studies identified in 4 databases (Web of Science, Scopus, OVID and CINAHL) were searched from inception to April 2025. DATA EXTRACTION: Two reviewers independently screened studies, extracted data, and assessed methodological quality using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. DATA ANALYSIS: Diagnostic accuracy outcomes were analyzed using a Bayesian bivariate random-effects model via MetaBayesDTA. Summary estimates were pooled where applicable, and summary receiver operating characteristic curves were generated to illustrate diagnostic performance. RESULTS: Of 1377 articles retrieved, 7 met inclusion criteria for the systematic review, and 6 were included in the pooled meta-analysis. These studies evaluated 4 different nutrition screening tools, including the Screening Tool for Childhood Cancer (SCAN), Screening Tool for Risk on Nutritional Status and Growth (STRONGkids), Pediatric Yorkhill Malnutrition Score (PYMS), and Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP). The meta-analysis evaluated the diagnostic performance of 3 nutritional risk screening tools-SCAN, STRONGkids, and PYMS-against anthropometric measurements and/or pediatric Subjective Global Nutritional Assessment (SGNA) as reference standards. SCAN demonstrated good to excellent sensitivity against body mass index (BMI; 89.0%; 95% CrI, 68.8-95.9) and SGNA (95.0%; 95% CrI, 72.9-98.9), though with poor to insufficient specificity. PYMS showed excellent sensitivity (91.0%; 95% CrI, 59.1-97.8), but poor specificity (43.3%; 95% CrI, 26.1-66.6) compared to BMI. CONCLUSION: SCAN and PYMS demonstrated high sensitivity but low specificity in identifying pediatric cancer patients at risk of malnutrition. Future research should focus on validation studies, aimed at standardizing the nutritional risk screening process in the pediatric oncology population. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration No. [CRD420251022898]. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the International Life Sciences Institute. FAU - Kangalgil, Melda AU - Kangalgil M AUID- ORCID: 0000-0003-2868-8903 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, 58140, Turkiye. FAU - Meral, Buket AU - Meral B AUID- ORCID: 0000-0003-1664-9333 AD - Department of Child Health and Diseases Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, 61080, Turkiye. FAU - Kucuk Erdol, Ebru AU - Kucuk Erdol E AUID- ORCID: 0000-0003-1182-7807 AD - Department of Obstetrics and Gynecology Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, 61080, Turkiye. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM OTO - NOTNLM OT - cancer OT - child OT - malnutrition OT - malnutrition screening tools OT - meta-analysis OT - nutritional screening EDAT- 2026/09/01 23:34 MHDA- 2026/09/01 23:34 CRDT- 2026/09/01 19:53 PHST- 2026/09/01 23:34 [medline] PHST- 2026/09/01 23:34 [pubmed] PHST- 2026/09/01 19:53 [entrez] AID - 8778819 [pii] AID - 10.1093/nutrit/nuag120 [doi] PST - aheadofprint SO - Nutr Rev. 2026 Sep 1:nuag120. doi: 10.1093/nutrit/nuag120. PMID- 42679805 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 2666-3791 (Electronic) IS - 2666-3791 (Linking) VI - 7 IP - 9 DP - 2026 Sep 15 TI - Maternal secretor status and human milk oligosaccharides influence the infant gut resistome. PG - 103007 LID - S2666-3791(26)00424-6 [pii] LID - 10.1016/j.xcrm.2026.103007 [doi] LID - 103007 AB - The infant gut resistome is established early in life and is shaped by perinatal exposures, yet the mechanisms underlying its modulation remain unclear. We combined shotgun metagenomics of fecal samples from 57 one-month-old infants and paired milk samples from 50 mothers in the MAMI cohort to investigate the influence of maternal secretor status on early-life resistome development. Longitudinal follow-up at 6 and 12 months, and also further validation in the independent Lifelines NEXT (LLNEXT) cohort, support our findings. Cesarean section (C-section) was associated with increased antibiotic resistance gene (ARG) diversity, whereas exclusive breastfeeding reduced ARG abundance and diversity. Maternal secretor status further modified resistome composition among exclusively breastfed infants. Human milk oligosaccharide profiling identified specific glycans underlying these associations, with 2'-fucosyllactose and 6'-sialyllactose showing negative correlations with distinct ARG classes. These findings identify human milk composition as a key determinant of early-life resistome assembly and a potential target for modulating antimicrobial resistance. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Samarra, Anna AU - Samarra A AD - Department of Biotechnology, Institute of Agrochemistry and Food Technology- National Research Council (IATA-CSIC), Paterna, Valencia, Spain; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: asamarramas@health.ucsd.edu. FAU - Alcaniz, Alejandro J AU - Alcaniz AJ AD - Department of Biotechnology, Institute of Agrochemistry and Food Technology- National Research Council (IATA-CSIC), Paterna, Valencia, Spain; Institute for Agribiotechnology Research (CIALE), Department of Microbiology and Genetics, University of Salamanca, Salamanca, Spain. FAU - Quijada, Narciso M AU - Quijada NM AD - Institute of Functional Biology and Genomics (IBFG), CSIC - USAL, Salamanca, Spain. FAU - Renwick, Simone AU - Renwick S AD - Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, CA 92093, USA. FAU - George, Sergio AU - George S AD - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pediatrics and Pediatric Surgery (Eastern Campus), Hospital Luis Calvo Mackenna, Faculty of Medicine, Universidad de Chile, Santiago, Chile. FAU - Sinha, Trishla AU - Sinha T AD - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. FAU - Martinez-Costa, Cecilia AU - Martinez-Costa C AD - Department of Pediatrics, School of Medicine, University of Valencia, Valencia, Spain; Pediatric Gastroenterology and Nutrition Section, Hospital Clinico Universitario Valencia, Valencia, Spain. FAU - Segata, Nicola AU - Segata N AD - Department CIBIO, University of Trento, Trento, Italy. FAU - Zhernakova, Alexandra AU - Zhernakova A AD - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. FAU - Bode, Lars AU - Bode L AD - Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, CA 92093, USA; Human Milk Institute, University of California, San Diego, La Jolla, CA 92093, USA. FAU - Collado, Maria Carmen AU - Collado MC AD - Department of Biotechnology, Institute of Agrochemistry and Food Technology- National Research Council (IATA-CSIC), Paterna, Valencia, Spain. Electronic address: mcolam@iata.csic.es. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - Cell Rep Med JT - Cell reports. Medicine JID - 101766894 RN - 0 (Oligosaccharides) RN - 0 (Trisaccharides) RN - XO2533XO8R (2'-fucosyllactose) RN - 0 (6'-sialyllactose) RN - J2B2A4N98G (Lactose) SB - IM MH - Humans MH - *Milk, Human/metabolism/chemistry MH - *Oligosaccharides/metabolism MH - Female MH - Infant MH - Breast Feeding MH - Feces/microbiology MH - Trisaccharides/metabolism MH - *Gastrointestinal Microbiome/genetics MH - Adult MH - Lactose/analogs & derivatives/metabolism MH - Cesarean Section MH - Drug Resistance, Microbial/genetics PMC - PMC13589485 OTO - NOTNLM OT - antibiotic resistance genes OT - breastfeeding OT - human milk oligosaccharides OT - infant resistome OT - maternal secretor status OT - microbiome OT - mode of delivery COIS- Declaration of interests The authors report there are no competing interests to declare. EDAT- 2026/09/01 23:34 MHDA- 2026/09/15 23:35 PMCR- 2026/09/01 CRDT- 2026/09/01 18:41 PHST- 2026/05/28 00:00 [received] PHST- 2026/06/25 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/15 23:35 [medline] PHST- 2026/09/01 23:34 [pubmed] PHST- 2026/09/01 18:41 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - S2666-3791(26)00424-6 [pii] AID - 103007 [pii] AID - 10.1016/j.xcrm.2026.103007 [doi] PST - ppublish SO - Cell Rep Med. 2026 Sep 15;7(9):103007. doi: 10.1016/j.xcrm.2026.103007. Epub 2026 Sep 1. PMID- 42678932 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260903 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 9 DP - 2026 TI - Physical activity in post-COVID-19 condition: A cross-sectional study. PG - e0357465 LID - 10.1371/journal.pone.0357465 [doi] LID - e0357465 AB - BACKGROUND: Post-COVID-19 condition (PCC) is a systemic disease which can negatively influence physical activity (PA). This study aimed to examine objectively measured PA and identify its factors in adults with PCC. METHODS: Cross-sectional analysis of baseline data from a randomised-controlled trial. PA was measured with accelerometry (ActiGraph wGT3X-BT) over eight consecutive days. The primary outcome, mean 24-hour Euclidean Norm Minus One (ENMO), and the secondary outcome, the intensity gradient, were analysed using multivariable linear regression models adjusted for pre-defined covariates. RESULTS: Among 153 participants, 141 (76.6% female, age range 18-80 years) had valid PA data and were included in the analysis. Median [IQR] time spent in moderate and vigorous PA was 45.9 [32.1-61.2] and 0.16 [0.04-0.6] minutes per day, respectively. The median ENMO was 9.03 [7.2-11.2], indicating low overall PA. In regression models, chronic symptomatic disease other than PCC (beta = -1.77, 95% CI = -2.93 to -0.61) and fatigue (beta = 0.09, 95% CI = 0.02 to 0.16) were associated with lower mean ENMO, while higher functional capacity was associated with higher mean ENMO (beta = 0.14, 95% CI = 0.05 to 0.24). For the intensity gradient, higher education and functional capacity were associated with a more favourable gradient. CONCLUSION: Presence of chronic symptomatic disease in addition to PCC, fatigue, functional capacity, and educational attainment were identified as factors of PA. These factors may be relevant for the development of therapeutic strategies to support physical activity; however, causal relationships cannot be inferred from the present study. CI - Copyright: (c) 2026 Kopp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kopp, Julia AU - Kopp J AUID- ORCID: 0009-0000-7871-8707 AD - Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben, Zurich, Switzerland. FAU - Spies Rodriguez, Dara Corina AU - Spies Rodriguez DC AD - Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben, Zurich, Switzerland. FAU - Kunzi, Lisa AU - Kunzi L AD - Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben, Zurich, Switzerland. FAU - Puhan, Milo A AU - Puhan MA AD - Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben, Zurich, Switzerland. FAU - Fehr, Jan Sven AU - Fehr JS AD - Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben, Zurich, Switzerland. FAU - Radtke, Thomas AU - Radtke T AUID- ORCID: 0000-0002-1723-1070 AD - Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben, Zurich, Switzerland. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Middle Aged MH - *Exercise/physiology MH - *COVID-19/physiopathology MH - Aged MH - Male MH - Adult MH - Post-Acute COVID-19 Syndrome MH - Aged, 80 and over MH - Accelerometry MH - Adolescent MH - Young Adult MH - SARS-CoV-2 MH - Fatigue PMC - PMC13533376 COIS- The authors have declared that no competing interests exist. EDAT- 2026/09/01 17:39 MHDA- 2026/09/01 17:40 PMCR- 2026/09/01 CRDT- 2026/09/01 13:33 PHST- 2026/01/15 00:00 [received] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/01 17:40 [medline] PHST- 2026/09/01 17:39 [pubmed] PHST- 2026/09/01 13:33 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - PONE-D-25-64893 [pii] AID - 10.1371/journal.pone.0357465 [doi] PST - epublish SO - PLoS One. 2026 Sep 1;21(9):e0357465. doi: 10.1371/journal.pone.0357465. eCollection 2026. PMID- 42677684 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260918 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Women's Experiences of Breastfeeding Beyond One Year: A Qualitative Systematic Review. PG - e70242 LID - 10.1111/mcn.70242 [doi] LID - e70242 AB - Breastfeeding beyond 1 year is recommended by the World Health Organisation and is linked to multiple maternal, infant, and environmental benefits. However, rates frequently remain low in high-income countries, which may relate to social stigma, work commitments and insufficient support. This review aimed to explore the experiences of women who breastfeed beyond 1 year. Accordingly, a qualitative systematic review following the Joanna Briggs Institute meta-aggregation approach and reported to the ENTREQ statement was undertaken. Searches were conducted in Ovid MEDLINE, Ovid EMBASE, CINAHL, and Web of Science from database inception to June 2026. Two reviewers were involved in the search, extraction, quality assessment and synthesis process. A total of 6831 articles were screened, and 36 studies were included, most of which were conducted in high-income countries. One hundred and thirty extracted findings were used to form 10 categories, which were developed into four synthesised findings: (1) society and culture impact acceptability and visibility of breastfeeding beyond 1 year; (2) structural and institutional constraints undermine breastfeeding beyond 1 year; (3) social networks and peer support influence breastfeeding beyond 1 year; and (4) breastfeeding beyond 1 year involves an interplay of bonding, empowerment, challenges, and adaptation. This review highlights the complex and often challenging contexts women face when breastfeeding beyond 1 year. Multi-level efforts to normalise and validate this practice are essential to better align with global health guidance. Future research should explore experiences of breastfeeding beyond 1 year in countries where it is more commonly practised. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Cronin, Thomas AU - Cronin T AUID- ORCID: 0000-0001-9522-3992 AD - School of Public Health, University College Cork, Cork, Ireland, Discipline of Public Health and Primary Care, School of Medicine, Trinity College Dublin, Dublin, Ireland. FAU - Ahmad, Noor Ainah Gulzar AU - Ahmad NAG AUID- ORCID: 0009-0000-2050-0721 AD - School of Medicine, Trinity College Dublin, Dublin, Ireland. FAU - McCarthy, Noel AU - McCarthy N AUID- ORCID: 0000-0003-1113-1017 AD - Discipline of Public Health and Primary Care, School of Medicine, Trinity College Dublin, Dublin, Ireland. LA - eng GR - HRBI_/Health Research Board/Ireland PT - Journal Article PT - Systematic Review PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - Social Support MH - Qualitative Research MH - *Mothers/psychology MH - Time Factors PMC - PMC13531375 OTO - NOTNLM OT - breastfeeding OT - experiences OT - qualitative OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/09/01 CRDT- 2026/09/01 06:35 PHST- 2026/07/09 00:00 [revised] PHST- 2025/12/04 00:00 [received] PHST- 2026/07/25 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 06:35 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - MCN70242 [pii] AID - 10.1111/mcn.70242 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70242. doi: 10.1111/mcn.70242. PMID- 42677197 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260901 LR - 20260902 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 9 DP - 2026 Sep TI - Alterations in Human Milk Adiponectin, Leptin, Resistin, and microRNAs in Mothers With Gestational Diabetes Mellitus Compared With Healthy Controls: A Systematic Review and Network-Based Analysis. PG - e72256 LID - 10.1002/fsn3.72256 [doi] LID - e72256 AB - Gestational diabetes mellitus (GDM) is linked to poor infant metabolic outcomes, potentially via altered human milk (HM) hormones and microRNAs. Since their specific roles remain unclear, this study synthesizes current evidence on HM adipose tissue-derived hormones (particularly adiponectin, leptin, and resistin) and microRNA modifications during gestational diabetes. Firstly, a systematic review following PRISMA 2020 guidelines was conducted (PROSPERO: CRD42024612813). Searches in major databases identified studies comparing HM adiponectin, leptin, or resistin concentrations and/or miRNA profiles between GDM and normoglycemic mothers. Secondly, bioinformatics analysis using miRWalk 3.0, functional enrichment, and network topology mapping examined miRNA interactions with ADIPOQ, LEP, and RETN genes. Twelve studies were included. Adiponectin showed the most consistent GDM-associated reductions, though findings were context-dependent. Leptin was primarily associated with maternal adiposity rather than GDM status. Resistin evidence was insufficient. Three miRNA studies revealed stage-dependent dysregulation in GDM, with miR-148a, miR-30b, let-7a, and let-7d linked to infant growth outcomes during the first 6 months. Bioinformatics identified miR-148a-5p and miR-30b-3p as targeting all three adipokine genes, with enrichment in glucose homeostasis and insulin resistance pathways. Network analysis highlighted TCF7L2, INSR, GCK, and HNF1A as central nodes. GDM is associated with selective alterations in HM adipokines and miRNAs, with adiponectin and specific miRNAs showing the strongest signals. These findings support a conceptual model where GDM shapes HM's molecular composition through interacting endocrine and posttranscriptional mechanisms, potentially influencing infant metabolic programming. Larger longitudinal studies are needed to validate these observations and determine clinical relevance. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Zhang, Zhijun AU - Zhang Z AD - Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy Xianning Medical College, Hubei University of Science and Technology Xianning Hubei Province P. R. China. FAU - Davoudi, Maryam AU - Davoudi M AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. FAU - Ghafourian, Amirreza AU - Ghafourian A AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. AD - Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran. FAU - Dehghan, Parmida AU - Dehghan P AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. AD - Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran. FAU - Ahmadi, Mojde AU - Ahmadi M AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. AD - Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran. FAU - Ayyoubzadeh, Seyed Mohammad AU - Ayyoubzadeh SM AUID- ORCID: 0000-0001-8450-7818 AD - Department of Medical Education, School of Medicine Tehran University of Medical Sciences Tehran Iran. FAU - Miao, Xiaolei AU - Miao X AD - Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy Xianning Medical College, Hubei University of Science and Technology Xianning Hubei Province P. R. China. FAU - Choobineh, Hamid AU - Choobineh H AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. FAU - Afrisham, Reza AU - Afrisham R AUID- ORCID: 0000-0001-8064-118X AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. LA - eng PT - Journal Article PT - Review DEP - 20260831 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13528237 OTO - NOTNLM OT - body weight OT - gestational diabetes OT - hormones OT - human milk OT - infant obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/08/31 CRDT- 2026/09/01 06:23 PHST- 2026/02/18 00:00 [received] PHST- 2026/07/11 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 06:23 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - FSN372256 [pii] AID - 10.1002/fsn3.72256 [doi] PST - epublish SO - Food Sci Nutr. 2026 Aug 31;14(9):e72256. doi: 10.1002/fsn3.72256. eCollection 2026 Sep. PMID- 42676987 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260901 LR - 20260902 IS - 2352-3409 (Electronic) IS - 2352-3409 (Linking) VI - 68 DP - 2026 Aug TI - Design and manufacturing data for an infant upper body physical model for bench testing of assistive devices. PG - 113099 LID - 10.1016/j.dib.2026.113099 [doi] LID - 113099 AB - Pediatric assistive devices require rigorous preliminary testing for safety and effectiveness before conducting trials with pediatric populations. Existing upper-body physical models for infants are often prohibitively expensive; meanwhile, more affordable alternatives frequently lack anthropometric accuracy or adequate joint mobility. This paper presents design and manufacturing data for a high-fidelity model that closely mirrors the physical properties of a six-month-old infant's upper body. A comprehensive guide to the design process, manufacturing, and assembly is also included. The model consists of the torso, upper arms, forearms, and hands, connected with articulated joints. Validation of the model's segments confirms close alignment with target metrics for size, mass distribution, and joint mobility. By adjusting the design parameters, the infant model can be scaled to represent older pediatric populations. This work offers a scalable framework for researchers to develop physical models for pediatric device testing. CI - (c) 2026 The Authors. FAU - Kuo, Emily AU - Kuo E AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Rauch, Chris AU - Rauch C AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Macaluso, Christian AU - Macaluso C AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Gowda, Aryan AU - Gowda A AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Ortega, Jonathan AU - Ortega J AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Castillo, Miriam Contreras AU - Castillo MC AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Barahona, Melanie AU - Barahona M AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - McCarty, Tristan AU - McCarty T AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Sahin, Ipsita AU - Sahin I AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Kokkoni, Elena AU - Kokkoni E AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. LA - eng PT - Journal Article DEP - 20260818 PL - Netherlands TA - Data Brief JT - Data in brief JID - 101654995 PMC - PMC13527506 OTO - NOTNLM OT - Additive manufacturing OT - Computer-aided design OT - Manikin EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/08/18 CRDT- 2026/09/01 06:07 PHST- 2026/03/12 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 06:07 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - S2352-3409(26)00647-5 [pii] AID - 113099 [pii] AID - 10.1016/j.dib.2026.113099 [doi] PST - epublish SO - Data Brief. 2026 Aug 18;68:113099. doi: 10.1016/j.dib.2026.113099. eCollection 2026 Aug. PMID- 42676574 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260901 LR - 20260902 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Bibliometric analysis of research on pediatric hypothyroidism treatment: a global perspective on trends and emerging fronts (2018-2026). PG - 1908940 LID - 10.3389/fped.2026.1908940 [doi] LID - 1908940 AB - BACKGROUND: Pediatric hypothyroidism is among the most prevalent endocrine disorders in childhood, yet no bibliometric analysis has systematically mapped the research landscape of its treatment. OBJECTIVE: This study aimed to characterize the publication trends, geographic distribution, research hotspots, and emerging fronts in pediatric hypothyroidism treatment research from 2018 to 2026. METHODS: A comprehensive search was conducted in the Web of Science Core Collection (WoSCC) as the primary database, with external data validation performed via PubMed. Bibliometric indicators were analyzed using CiteSpace, Python and R. Keyword co-occurrence networks were constructed with Louvain community detection, and burst detection was performed to identify emerging research fronts. RESULTS: A total of 1,302 publications were included. Annual output grew from 138 (2018) to a peak of 183 (2022). The United States (n = 263, 20.2%), China (n = 203, 15.6%), and Italy (n = 137, 10.5%) were the leading contributors. Five thematic clusters were identified: (1) congenital hypothyroidism and neonatal screening; (2) subclinical hypothyroidism; (3) pregnancy-related thyroid disorders; (4) autoimmune thyroid disease; and (5) comorbidities and genetic syndromes. Burst detection revealed "obesity" (burst strength = 7.2), "COVID-19" (4.0), and "thyroid dyshormonogenesis" (3.2) as emerging fronts. CONCLUSIONS: The field is shifting focus from congenital hypothyroidism screening optimization toward subclinical hypothyroidism management and the recognition of obesity-related TSH elevation as a distinct physiological entity. Future research should prioritize prospective trials on watchful-waiting strategies and obesity-specific TSH reference ranges. CI - (c) 2026 Wu, Sun, Liu, Huang, Liu, Qiu and Wang. FAU - Wu, Wei AU - Wu W AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Sun, Zhengyun AU - Sun Z AD - Department of Radiology, Lincang First People's Hospital, Lincang, Yunnan, China. FAU - Liu, Mengxun AU - Liu M AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Huang, Yu AU - Huang Y AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Liu, Tingting AU - Liu T AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Qiu, Xiaobing AU - Qiu X AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Wang, Yuanbiao AU - Wang Y AD - Department of Colorectal Surgery, The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital, Kunming, Yunnan, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260817 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13526919 OTO - NOTNLM OT - congenital hypothyroidism OT - levothyroxine OT - neonatal screening OT - pediatric hypothyroidism OT - subclinical hypothyroidism COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/08/17 CRDT- 2026/09/01 05:30 PHST- 2026/06/14 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 05:30 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - 10.3389/fped.2026.1908940 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 17;14:1908940. doi: 10.3389/fped.2026.1908940. eCollection 2026. PMID- 42676515 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260902 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Early and sex-specific dynamic changes of the modified Glasgow Prognostic Score correlate with survival and immunotoxicities in patients undergoing allogeneic hematopoietic stem cell transplantation. PG - 1894926 LID - 10.3389/fimmu.2026.1894926 [doi] LID - 1894926 AB - Risk assessment before allogeneic hematopoietic stem cell transplantation (alloHSCT) is essential to estimate treatment-related morbidity and mortality; the hematopoietic cell transplantation-comorbidity index (HCT-CI) is widely used. The modified Glasgow Prognostic Score (mGPS), reflecting systemic inflammation and nutritional status, is a validated prognostic marker in solid tumors, but ill-defined in alloHSCT. We evaluated the prognostic impact of mGPS before and early after alloHSCT on overall survival (OS), non-relapse mortality (NRM), and acute graft-versus-host disease (aGvHD). We analyzed 442 consecutive alloHSCT patients (2012-2017, University Hospital Cologne). Outcomes were assessed by mGPS pre-transplant (preTx), at day+30, and by dynamic changes (Delta(30)mGPS). Subgroup analyses included transplant characteristics and sex. Patients with mGPS 2 preTx had inferior OS (HR 2.32, p<0.0001) and NRM (HR 2.31, p=0.002). Moreover, Delta(30)mGPS changes indicated poorer OS and NRM rates more strongly (Delta(30)mGPS(1-->2vs0-->1): OS: HR 2.85, p=0.02; NRM: HR 3.99, p=0.05). Findings regarding aGvHD were conflicting. Multivariable analysis confirmed mGPS as an independent prognostic factor for survival. Sex-specific analyses revealed distinct risk patterns. These findings highlight the prognostic relevance of the immunonutritional status before and early after alloHSCT, warranting prospective studies to further validate the mGPS for refined risk stratification. CI - Copyright (c) 2026 Thurisch, Althoff, Leuchte, Shahbaz, Funk, Kirmaier, Hadzic, Oganesian, Carboniero, Vona, Geier, Muschik, Cordas dos Santos, von Bergwelt-Baildon, Holtick, Scheid and Theurich. FAU - Thurisch, Hannah AU - Thurisch H AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. FAU - Althoff, Kathrin C AU - Althoff KC AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. AD - Department of Otorhinolaryngology, University of Lubeck, Lubeck, Germany. FAU - Leuchte, Katharina AU - Leuchte K AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. AD - National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark. FAU - Shahbaz, Wajma AU - Shahbaz W AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Funk, Maximilian A AU - Funk MA AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. FAU - Kirmaier, Martin E AU - Kirmaier ME AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Hadzic, Amar AU - Hadzic A AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Oganesian, Sabine AU - Oganesian S AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Carboniero, Adriano AU - Carboniero A AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. FAU - Vona, Ludovica AU - Vona L AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Geier, Caroline AU - Geier C AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Muschik, Lena AU - Muschik L AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Cordas Dos Santos, David M AU - Cordas Dos Santos DM AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - von Bergwelt-Baildon, Michael AU - von Bergwelt-Baildon M AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. FAU - Holtick, Udo AU - Holtick U AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. FAU - Scheid, Christof AU - Scheid C AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. FAU - Theurich, Sebastian AU - Theurich S AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. LA - eng PT - Journal Article DEP - 20260817 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation/adverse effects/mortality MH - Male MH - Female MH - *Graft vs Host Disease/etiology/mortality MH - Middle Aged MH - Adult MH - Prognosis MH - Transplantation, Homologous MH - Sex Factors MH - Young Adult MH - Adolescent MH - Risk Assessment MH - Aged MH - Retrospective Studies PMC - PMC13526978 OTO - NOTNLM OT - allogeneic hematopoietic stem cell transplantation OT - graft-versus-host disease OT - immunonutritional status OT - inflammation OT - metabolism OT - risk assessment COIS- The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author ST declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/08/17 CRDT- 2026/09/01 05:22 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 05:22 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1894926 [doi] PST - epublish SO - Front Immunol. 2026 Aug 17;17:1894926. doi: 10.3389/fimmu.2026.1894926. eCollection 2026. PMID- 42676383 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260901 LR - 20260902 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Association between prognostic nutritional index and complications in children with immunoglobulin A vasculitis. PG - 1853071 LID - 10.3389/fnut.2026.1853071 [doi] LID - 1853071 AB - OBJECTIVE: This study aimed to evaluate the correlation between prognostic nutritional index (PNI) and complications in immunoglobulin A vasculitis (IgAV) children, including vomiting, abdominal pain, bloody stools, and proteinuria. METHODS: A retrospective study was conducted on 732 children diagnosed with IgAV at the Xiangtan Central Hospital of the Hunan University between 2014 and 2025. Logistic regression analyses, subgroup analysis, sensitivity analysis, and receiver operating characteristic (ROC) curves were employed to evaluate the association between PNI and vomiting, abdominal pain, bloody stool, and proteinuria. RESULTS: Multivariate logistic regression analysis indicated that, each unit increase and one standard deviation (SD) increase in the PNI was associated with a 9.4% reduction (OR = 0.906) and a 50.5% reduction (OR = 0.495) in the risk of vomiting, respectively. Compared to the low PNI group, the high PNI group exhibited a 55.4% reduction in the risk of vomiting (OR = 0.446). Additionally, each unit increase and one SD increase in PNI were linked to a 6.7% (OR = 0.933) and a 38.9% (OR = 0.611) reduction in the risk of abdominal pain, respectively. Furthermore, the high PNI group demonstrated a 60.4% reduction in the risk of abdominal pain (OR = 0.396). For each unit increase and one SD increase in PNI, the risk of bloody stools decreased by 4.9% (OR = 0.951) and 30.3% (OR = 0.697), respectively. Moreover, the high PNI group exhibited a 52.2% reduction in the risk of bloody stools (OR = 0.478). Additionally, for each unit increase and one SD increase in PNI, the risk of proteinuria decreased by 6.6% (OR = 0.934) and 38.5% (OR = 0.615), respectively. Compared to the low PNI group, the high PNI group exhibited a 47.0% reduction in the risk of proteinuria (OR = 0.530). And Most subgroup and sensitivity analyses confirmed the stability of the results (p < 0.05). ROC analysis indicated that PNI was significantly correlated with vomiting, abdominal pain, bloody stools, and proteinuria (p < 0.05). CONCLUSION: Higher levels of PNI were significantly associated with a lower risk of vomiting, abdominal pain, bloody stools, and proteinuria in IgAV children. CI - Copyright (c) 2026 Xiong, Liu, Li, Zhou and Yu. FAU - Xiong, Xiao AU - Xiong X AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. FAU - Liu, Zezheng AU - Liu Z AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. FAU - Li, Huan AU - Li H AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. FAU - Zhou, Yinfei AU - Zhou Y AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. FAU - Yu, Li AU - Yu L AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. LA - eng PT - Journal Article DEP - 20260817 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13526555 OTO - NOTNLM OT - abdominal pain OT - bloody stool OT - immunoglobulin A vasculitis OT - prognostic nutritional index OT - proteinuria OT - vomiting COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/01 13:23 MHDA- 2026/09/01 13:24 PMCR- 2026/08/17 CRDT- 2026/09/01 05:02 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/01 13:24 [medline] PHST- 2026/09/01 13:23 [pubmed] PHST- 2026/09/01 05:02 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - 10.3389/fnut.2026.1853071 [doi] PST - epublish SO - Front Nutr. 2026 Aug 17;13:1853071. doi: 10.3389/fnut.2026.1853071. eCollection 2026. PMID- 42675825 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260907 IS - 1643-3750 (Electronic) IS - 1234-1010 (Print) IS - 1234-1010 (Linking) VI - 32 DP - 2026 Sep 1 TI - Development and Clinical Feasibility of a Computer-Assisted Shape Design and Bending System for Spinal Fixation Rods. PG - e952722 LID - 10.12659/MSM.952722 [doi] LID - e952722 AB - BACKGROUND Spinal pedicle screw-rod fixation is widely used, but manual rod bending is time-consuming and prone to contour inconsistencies. Although computer-assisted technologies have been explored, existing systems remain limited by cost, complexity, and insufficient precision. This study evaluated a novel computer-assisted rod design and bending system, with the goal of testing whether computer-assisted rod bending reduces bending plus installation time vs manual bending in unilateral paired cases and to evaluate safety, feasibility, and rod-screw fitting accuracy. MATERIAL AND METHODS A prospective trial enrolled 26 patients (18-75 years) undergoing spinal pedicle screw-rod fixation (>/=4 segments) for fractures or degenerative diseases. Twenty patients received unilateral computer-assisted bending (contralateral manual for comparison) and 6 received bilateral assisted bending. The primary outcome was bending plus installation time; secondary outcomes included complications and fitting accuracy. Wilcoxon signed-rank test was used (P<0.05). RESULTS No instrument-related complications were observed (n=26; median age 60.5 years). For 20 unilateral cases, computer-assisted bending (183.3+/-70.8 seconds) was significantly shorter than manual bending (236.1+/-119.1 s; mean reduction 52.75 seconds, P=0.017). Subgroup analyses indicated signals of greater time savings in more than 4 segments (93.9 seconds, P=0.039) and BMI of 25 kg/m2 or higher (95.3 seconds, P=0.005), although these were exploratory and not adjusted for multiplicity. CONCLUSIONS The computer-assisted system reduced bending plus installation time vs manual bending, with no instrument-related complications. Subgroup findings were exploratory and require further validation. FAU - Li, Xingye AU - Li X AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Weijun AU - Zhang W AUID- ORCID: 0009-0000-0688-4036 AD - School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, China. AD - TINAVI Medical Technologies Co., Ltd., Beijing, China. FAU - Xu, Zhongning AU - Xu Z AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - Zhao, Yongqiang AU - Zhao Y AD - TINAVI Medical Technologies Co., Ltd., Beijing, China. FAU - An, Yan AU - An Y AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - Li, Qingyun AU - Li Q AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - He, Da AU - He D AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental and clinical research JID - 9609063 SB - IM MH - Humans MH - Middle Aged MH - Female MH - Adult MH - Prospective Studies MH - Aged MH - Male MH - Adolescent MH - Pedicle Screws MH - Feasibility Studies MH - *Computer-Aided Design MH - *Fracture Fixation, Internal/methods/instrumentation MH - Young Adult MH - *Spinal Fusion/methods/instrumentation MH - *Surgery, Computer-Assisted/methods PMC - PMC13545973 COIS- Conflict of interest: None declared EDAT- 2026/09/01 05:41 MHDA- 2026/09/01 05:42 PMCR- 2026/09/01 CRDT- 2026/09/01 01:23 PHST- 2026/09/01 05:42 [medline] PHST- 2026/09/01 05:41 [pubmed] PHST- 2026/09/01 01:23 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 952722 [pii] AID - 10.12659/MSM.952722 [doi] PST - epublish SO - Med Sci Monit. 2026 Sep 1;32:e952722. doi: 10.12659/MSM.952722. PMID- 42675564 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260903 IS - 1932-846X (Electronic) IS - 1932-8451 (Print) IS - 1932-8451 (Linking) VI - 86 IP - 4 DP - 2026 Oct TI - Does the Gut Microbiota Play a Role in Attention-Deficit/Hyperactivity Disorder in Childhood? A Pilot Study From Turkey. PG - e70057 LID - 10.1002/dneu.70057 [doi] LID - e70057 AB - The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) is not fully understood, but increasing evidence suggests that gut microbiota may play a role. This study compared the gut microbiota of children with ADHD with that of a control group of healthy children, and examined their dietary and sleep habits. Ten medication-naive children aged 612 years who had recently been diagnosed with ADHD and ten healthy controls were included. ADHD diagnoses were confirmed using the Schedule for Affective Disorders and Schizophrenia for School-Age ChildrenPresent and Lifetime Version (K-SADS-PL). Sleep and eating habits were assessed using the 2nd Level Sleep Disorder Short Form, the Children's Eating Behaviour Inventory, and a form to collect sociodemographic and clinical information. The gut microbiota were analysed using 16S NGS metagenome analysis. A significant decrease in the Shannon and Simpson diversity index values was observed in the ADHD group compared to the control group. Despite the presence of a percentage difference, no statistically significant differences were observed between the groups with respect to species, genus, family, order, class or phylum. Following evaluation of the sleep and eating habit scale scores, no statistically significant difference between the groups was determined.These findings suggests that children with ADHD may alter gut microbiota diversity.However, the absence of significant taxonomic differences and the small sample size mean that these results should be interpreted with caution. Further, larger, adequately powered studies are needed to validate these findings and clarify the potential role of gut microbiota in the pathophysiology of ADHD. CI - (c) 2026 Wiley Periodicals LLC. FAU - Akyol, Cansin Kardelen AU - Akyol CK AUID- ORCID: 0000-0002-8772-3476 AD - Department of Child and Adolescent Psychiatry, Akhisar State Hospital, Manisa, Turkey. FAU - Bilac, Oznur AU - Bilac O AUID- ORCID: 0000-0001-8369-6215 AD - Department of Child and Adolescent Psychiatry, Manisa Celal Bayar University, Manisa, Turkey. FAU - Cam, Fethi Sirri AU - Cam FS AUID- ORCID: 0000-0002-0972-8896 AD - Department of Medical Genetics, Manisa Celal Bayar University, Manisa, Turkey. LA - eng GR - 2022-146/Manisa Celal Bayar University Scientific Research Projects Coordination Unit/ PT - Journal Article PL - United States TA - Dev Neurobiol JT - Developmental neurobiology JID - 101300215 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/microbiology/physiopathology MH - Male MH - Pilot Projects MH - *Gastrointestinal Microbiome/physiology MH - Turkey MH - Female MH - Child MH - Feeding Behavior/physiology MH - Sleep/physiology PMC - PMC13530312 OTO - NOTNLM OT - Attention-deficit/hyperactivity disorder (ADHD) OT - gut microbiota OT - hyperactivity OT - impulsivity OT - inattention OT - neurodevelopmental disorder COIS- The authors declare no conflicts of interest. EDAT- 2026/09/01 05:41 MHDA- 2026/09/01 05:42 PMCR- 2026/09/01 CRDT- 2026/09/01 00:13 PHST- 2026/07/10 00:00 [revised] PHST- 2026/02/20 00:00 [received] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/09/01 05:42 [medline] PHST- 2026/09/01 05:41 [pubmed] PHST- 2026/09/01 00:13 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - DNEU70057 [pii] AID - 10.1002/dneu.70057 [doi] PST - ppublish SO - Dev Neurobiol. 2026 Oct;86(4):e70057. doi: 10.1002/dneu.70057. PMID- 42675534 OWN - NLM STAT- Publisher LR - 20260901 IS - 2542-5641 (Electronic) IS - 0366-6999 (Linking) DP - 2026 Sep 1 TI - Single-cell RNA sequencing uncovers m6A regulator-defined T-cell subpopulations and YTHDF1-HSP90AB1-MYC therapeutic axis in T-cell acute lymphoblastic leukemia. LID - 10.1097/CM9.0000000000004239 [doi] AB - BACKGROUND: N6-methyladenosine (m6A) drives T-cell acute lymphoblastic leukemia (T-ALL); however, its roles in leukemic heterogeneity and tumor microenvironment remodeling unclear. This study characterized N6-methyladenosine regulator-defined subpopulations and YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) in leukemogenesis. METHODS: Integrated single-cell and bulk RNA sequencing from 17 pediatric T-cell acute lymphoblastic leukemia patients and 3 healthy donors were analyzed. Non-negative matrix factorization based on m6A regulator expression identified distinct T-cell subpopulations. CellChat, Monocle, and single-cell regulatory network inference and clustering analyses revealed intercellular communication patterns, developmental trajectories, and transcriptional regulatory programs. Functional validations included lentiviral-mediated YTHDF1 knockdown in Jurkat and Molt4 cells for proliferation, apoptosis, and migration assays, and a non-obese diabetic severe combined immunodeficiency mouse xenograft model. Methylated RNA immunoprecipitation quantitative polymerase chain reaction, RNA immunoprecipitation quantitative polymerase chain reaction, RNA stability assays, and Western blotting characterized YTHDF1 interactions with heat shock protein 90 alpha family class B member 1 (HSP90AB1). RESULTS: Single-cell transcriptomics identified m6A-defined T-cell subpopulations in T-ALL. YTHDF1-enriched cells exhibited hypoxia and cell-cycle programs, occupied early developmental states, and communicated with macrophages. Knockdown suppressed proliferation and migration, increased apoptosis, and reduced leukemic burden in vivo. The protein bound and stabilized m6A-modified HSP90AB1 to sustain MYC proto-oncogene signaling. CONCLUSION: This study identified a YTHDF1-high m6A-associated T-cell subpopulation in T-ALL. YTHDF1 promoted leukemic progression through regulation of the HSP90AB1-MYC axis and was associated with altered macrophage-related intercellular signaling. CI - Copyright (c) 2026 The Chinese Medical Association, produced by Wolters Kluwer Health, LLC. under the CC-BY-NC-ND license. FAU - Liu, Chao AU - Liu C AD - Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China. FAU - Wang, Weimin AU - Wang W FAU - Wang, Fang AU - Wang F FAU - Xing, Haizhou AU - Xing H FAU - Cao, Weijie AU - Cao W FAU - Jiang, Zhongxing AU - Jiang Z LA - eng PT - Journal Article DEP - 20260901 PL - China TA - Chin Med J (Engl) JT - Chinese medical journal JID - 7513795 SB - IM OTO - NOTNLM OT - Heat shock protein 90 alpha family class B member 1 OT - N6-methyladenosine OT - Single-cell RNA sequencing OT - T-cell acute lymphoblastic leukemia EDAT- 2026/09/01 05:41 MHDA- 2026/09/01 05:41 CRDT- 2026/09/01 00:12 PHST- 2025/04/21 00:00 [received] PHST- 2026/09/01 05:41 [medline] PHST- 2026/09/01 05:41 [pubmed] PHST- 2026/09/01 00:12 [entrez] AID - 00029330-990000000-02208 [pii] AID - 10.1097/CM9.0000000000004239 [doi] PST - aheadofprint SO - Chin Med J (Engl). 2026 Sep 1. doi: 10.1097/CM9.0000000000004239. PMID- 42674753 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260930 IS - 1532-656X (Electronic) IS - 0891-5245 (Linking) VI - 40 IP - 5 DP - 2026 Sep-Oct TI - Beyond "Picky Eating": Identification, Screening, and Referral for Pediatric Feeding Disorders in Primary Care. PG - 770-781 LID - S0891-5245(26)00129-X [pii] LID - 10.1016/j.pedhc.2026.05.011 [doi] AB - Pediatric feeding disorders (PFDs) affect 1 in 37 children under age 5 in the United States, representing a common yet frequently underrecognized condition in primary care. In 2019, a multidisciplinary expert panel established the first consensus definition of PFD, creating a standardized four-domain framework (medical, nutritional, feeding skill, and psychosocial) that has transformed clinical assessment and management. A recent 2025 consensus further clarified the relationship between PFD and avoidant/restrictive food intake disorder (ARFID), providing guidance on diagnostic overlap and differentiation. This continuing education article provides pediatric healthcare providers with current, evidence-based knowledge to screen, identify, and make appropriate referrals for children with PFDs. The article reviews the consensus definitions, epidemiology, validated screening tools, differential diagnosis, risk factors, assessment strategies, and referral guidelines. A case-based example illustrates the application of the four-domain framework in clinical practice. With appropriate early identification and intervention, most children with feeding difficulties can achieve improved nutritional status, oral-motor development, and positive mealtime experiences. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Taha, Asma A AU - Taha AA AD - School of Nursing, California State University, Fullerton, CA; Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. Electronic address: ataha@fullerton.edu. FAU - Sahl, Sarah F AU - Sahl SF AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Farrell, Julia R AU - Farrell JR AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Wright, Amber AU - Wright A AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Frazier, Kelsey AU - Frazier K AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Doan, Sylvia AU - Doan S AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR; Division of Gastroenterology, Department of Pediatrics, School of Medicine, Oregon Health & Science University, Portland, OR. LA - eng PT - Journal Article PT - Review PL - United States TA - J Pediatr Health Care JT - Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners JID - 8709735 SB - IM MH - Child, Preschool MH - Humans MH - Infant MH - Avoidant Restrictive Food Intake Disorder MH - Diagnosis, Differential MH - *Feeding and Eating Disorders/diagnosis MH - *Feeding and Eating Disorders of Childhood/diagnosis/therapy/epidemiology MH - *Mass Screening/methods MH - Practice Guidelines as Topic MH - *Primary Health Care MH - *Referral and Consultation MH - Risk Factors MH - United States/epidemiology OTO - NOTNLM OT - Avoidant/restrictive food intake disorder (ARFID) OT - Multidisciplinary assessment OT - Pediatric feeding disorder (PFD) OT - Pediatric primary care OT - Screening and early identification COIS- CONFLICTS OF INTEREST None to report. EDAT- 2026/08/31 23:43 MHDA- 2026/08/31 23:44 CRDT- 2026/08/31 20:54 PHST- 2026/02/13 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/08/31 23:44 [medline] PHST- 2026/08/31 23:43 [pubmed] PHST- 2026/08/31 20:54 [entrez] AID - S0891-5245(26)00129-X [pii] AID - 10.1016/j.pedhc.2026.05.011 [doi] PST - ppublish SO - J Pediatr Health Care. 2026 Sep-Oct;40(5):770-781. doi: 10.1016/j.pedhc.2026.05.011. PMID- 42674301 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261028 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 415 DP - 2026 Dec 15 TI - Emotion regulation and state body image during daily body-exposure situations: A pilot ecological momentary assessment study. PG - 122447 LID - S0165-0327(26)01300-5 [pii] LID - 10.1016/j.jad.2026.122447 [doi] AB - BACKGROUND: Emotion regulation has been consistently associated with eating disorder psychopathology, yet most evidence comes from retrospective and cross-sectional studies. Ecological momentary assessment (EMA) allows these processes to be examined as they unfold during daily body-exposure situations. This pilot study investigated associations among emotion regulation strategies, affect, and state body image during naturally occurring body-exposure situations and explored whether average regulatory patterns across a two-week EMA period were associated with short-term change in drive for thinness. METHOD: Thirty-four young adults completed a 14-day EMA protocol combining event-based and end-of-day assessments. Event-level measures included state body image, positive and negative affect, cognitive reappraisal, expressive suppression, and rumination. Drive for thinness was assessed at baseline and post-monitoring. Pearson correlations examined associations among participant-level averages, a linear mixed-effects model tested event-level associations, and multiple regression examined whether average emotion regulation variables were associated with post-monitoring drive for thinness after controlling for baseline scores. RESULTS: Participants completed 305 EMA entries, corresponding to 64.08% adherence. More positive average body image was associated with higher positive affect and lower negative affect, expressive suppression, and rumination. At the event level, greater expressive suppression and rumination were associated with poorer state body image, whereas cognitive reappraisal was not. Baseline drive for thinness was significantly associated with post-monitoring scores. None of the EMA-derived emotion regulation variables was significantly associated with post-monitoring drive for thinness after controlling for baseline levels. DISCUSSION: These preliminary findings suggest that expressive suppression and rumination may co-occur with poorer state body image during everyday body-salient situations. Larger EMA studies using parallel and validated measures of emotion regulation are needed to clarify these associations and their temporal relevance. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Rojas-Rincon, Juliana AU - Rojas-Rincon J AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Gamiz-Sanfeliu, Maria AU - Gamiz-Sanfeliu M AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Ampatzoglou, Aikaterini AU - Ampatzoglou A AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Carballo-Marquez, Anna AU - Carballo-Marquez A AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Garolera, Maite AU - Garolera M AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain; Brain, Cognition, and Behavior Research Group, Consorci Sanitari de Terrassa-Hospital Universitari, 08227, Terrassa, Spain. FAU - Fernandez-Capo, Maria AU - Fernandez-Capo M AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Porras-Garcia, Bruno AU - Porras-Garcia B AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain; Brain, Cognition, and Behavior Research Group, Consorci Sanitari de Terrassa-Hospital Universitari, 08227, Terrassa, Spain. Electronic address: bporras@uic.es. LA - eng PT - Journal Article DEP - 20260901 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM EIN - J Affect Disord. 2026 Oct 28:122659. doi: 10.1016/j.jad.2026.122659. PMID: 42951731 MH - Humans MH - *Emotional Regulation MH - *Ecological Momentary Assessment MH - Pilot Projects MH - *Body Image/psychology MH - Female MH - Male MH - Young Adult MH - Rumination, Cognitive MH - Affect MH - Adult MH - Thinness/psychology MH - Adolescent OTO - NOTNLM OT - Affect OT - Body image OT - Eating disorders OT - Ecological momentary assessment OT - Emotion regulation OT - Prevention OT - Rumination OT - Suppression COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/31 23:43 MHDA- 2026/09/25 23:47 CRDT- 2026/08/31 19:14 PHST- 2026/05/13 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/09/25 23:47 [medline] PHST- 2026/08/31 23:43 [pubmed] PHST- 2026/08/31 19:14 [entrez] AID - S0165-0327(26)01300-5 [pii] AID - 10.1016/j.jad.2026.122447 [doi] PST - ppublish SO - J Affect Disord. 2026 Dec 15;415:122447. doi: 10.1016/j.jad.2026.122447. Epub 2026 Sep 1. PMID- 42674154 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261009 IS - 1873-6963 (Electronic) IS - 0965-2299 (Linking) VI - 102 DP - 2026 Nov TI - Perceptual-motor vision training approaches for the prevention of computer vision syndrome in college students: A narrative review. PG - 103427 LID - S0965-2299(26)00110-X [pii] LID - 10.1016/j.ctim.2026.103427 [doi] AB - Computer Vision Syndrome (CVS), also referred to as Digital Eye Strain (DES), is a common condition among college students and other digital-device users and is associated with prolonged near work, reduced blinking, and sustained visual attention. Conventional preventive strategies, including ergonomic optimization and scheduled visual breaks, primarily address environmental risk factors but do not directly target the perceptual-motor mechanisms underlying visual fatigue and oculomotor inefficiency. Perceptual-Motor Vision Training (PMVT) is an emerging complementary, non-pharmacological approach designed to enhance accommodation, vergence, oculomotor control, visuomotor integration, and visual information processing through structured visuomotor exercises. This narrative review synthesizes evidence from vision science, motor learning, and applied performance research to evaluate the potential role of PMVT in preventing or mitigating CVS-related visual fatigue in college students. Available evidence suggests that PMVT may improve selected visual and visuomotor functions. However, because most supporting studies involve athletic, pediatric, clinical, or non-CVS populations, its effectiveness for preventing CVS in healthy college students remains unproven. PMVT should therefore be considered an investigational complementary approach alongside ergonomic and behavioral strategies. Despite promising theoretical and preliminary empirical support, current evidence is limited by heterogeneous outcome measures, a scarcity of randomized controlled trials in non-athletic populations, and insufficient specification of training dosage and protocols. Future interdisciplinary research is required to establish standardized perceptual-motor metrics, determine dose-response relationships, and evaluate the clinical effectiveness and feasibility of PMVT as a low-cost complementary intervention for reducing digital task-related visual fatigue and improving visual performance in student populations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Zhong, Huihui AU - Zhong H AD - Suzhou Polytechnic University, Suzhou 215002, China. FAU - Gao, Dongxu AU - Gao D AD - Division of Sports Science and Physical Education, Tsinghua University, Beijing 100084, China. Electronic address: gdx@tsinghua.edu.cn. FAU - Xiao, Youlin AU - Xiao Y AD - Sports College, Dalian University, Dalian 116622, China. FAU - Wang, Yusen AU - Wang Y AD - Southwest University of Political Science and Law, Yubei 401120, China. FAU - Dong, Xiushen AU - Dong X AD - Normal University, Changsha City, Hunan Province 410081, China. FAU - Zhao, Zihao AU - Zhao Z AD - School of Medicine, Shaanxi University of Chinese Medicine, Xianyang 712000, China. LA - eng PT - Journal Article PT - Review DEP - 20260831 PL - Scotland TA - Complement Ther Med JT - Complementary therapies in medicine JID - 9308777 SB - IM MH - Humans MH - Students MH - *Asthenopia/prevention & control MH - Universities MH - Digital Media OTO - NOTNLM OT - Computer vision syndrome OT - Perceptual-Motor Vision Training OT - Perceptual-motor skills OT - Visual performance OT - Visuomotor learning COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/31 23:43 MHDA- 2026/10/09 23:31 CRDT- 2026/08/31 19:11 PHST- 2026/01/23 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/10/09 23:31 [medline] PHST- 2026/08/31 23:43 [pubmed] PHST- 2026/08/31 19:11 [entrez] AID - S0965-2299(26)00110-X [pii] AID - 10.1016/j.ctim.2026.103427 [doi] PST - ppublish SO - Complement Ther Med. 2026 Nov;102:103427. doi: 10.1016/j.ctim.2026.103427. Epub 2026 Aug 31. PMID- 42673582 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260917 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Aug 31 TI - Remote Assessment of Physical Function and Physical Activity in Adults With Autism Spectrum Disorder: Protocol for Feasibility, Validity, and Reliability Study. PG - e86020 LID - 10.2196/86020 [doi] LID - e86020 AB - BACKGROUND: Adults with autism spectrum disorder (ASD) are at increased risk for chronic health conditions and reduced quality of life (QoL), often linked to lower physical activity (PA), motor impairments, and barriers to health care access. Although communication and social differences in ASD are well documented, motor impairments such as deficits in coordination, balance, and gait remain understudied in adulthood despite their relevance to fall risk and PA participation. Telehealth and wearable technologies may improve access to physical therapy assessment and remote monitoring of physical function in this underserved population. OBJECTIVE: This pilot study aims to evaluate the feasibility, construct validity, and rating reliability of remotely administered physical function and balance assessments in adults with ASD and to examine racial and ethnic disparities and associations among physical function, PA, fall risk, and QoL. METHODS: This pilot study uses a 2-phase, cross-sectional, noninterventional design with remote data collection in legally independent adults aged 18-59 years with ASD who were recruited through the Simons Powering Autism Research and Knowledge (SPARK) registry. Participants complete self-report questionnaires; 2 weeks of wearable step monitoring using a Fitbit Inspire 3 (Google LLC) device; and, for a randomized subset of 25 participants, 1 remote, telehealth-based physical function assessment session. Remote performance-based measures include the Five Times Sit-to-Stand, 30-second Sit-to-Stand, standing balance under eyes open and eyes closed conditions, and single-leg stance under eyes open and eyes closed conditions. Construct validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures will be examined using hypothesis testing with related indicators of health and functioning, including steps per day, lower-extremity functional outcome surveys, fall risk screening surveys, and comorbidity burden. Interrater and intrarater reliability of remote performance scoring will be evaluated from video-recorded sessions scored by 6 raters using intraclass correlation coefficients. Secondary analyses will examine racial and ethnic disparities in physical function, PA, and QoL, as well as associations among these variables and moderation by race and ethnicity. RESULTS: Study funding was available from August 2024 to May 2025. Recruitment occurred from December 2024 to March 2025, and final data collection was completed in May 2025. By May 2025, 155 adults with ASD had been recruited, of whom 65.2% were female and 77% identified as Black or Hispanic. Data analysis is projected to be completed in July 2026, and submission of the primary results manuscript is anticipated in August 2026. CONCLUSIONS: This protocol describes a pilot study designed to evaluate the feasibility, construct validity, and equity relevance of remotely administered physical function assessments in adults with ASD. If supported, the findings may provide preliminary evidence for more accessible telehealth-based assessment approaches and inform larger studies on physical functioning, PA, and QoL in this population. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/86020. CI - (c)Annabel Nunez-Gaunaurd, Melissa M Tovin, Melissa Hale, Tan Li, Anjana Bhat. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 31.08.2026. FAU - Nunez-Gaunaurd, Annabel AU - Nunez-Gaunaurd A AUID- ORCID: 0000-0002-2977-7994 AD - Department of Physical Therapy, Nicole Wertheim College of Nursing & Health Sciences, Florida International University, Miami, FL, United States. FAU - Tovin, Melissa M AU - Tovin MM AUID- ORCID: 0000-0003-1355-3117 AD - Department of Physical Therapy, Miller School of Medicine, University of Miami, Miami, FL, United States. FAU - Hale, Melissa AU - Hale M AUID- ORCID: 0000-0001-5963-4794 AD - Division Director, Child and Family Services, College of Arts and Sciences, University of Miami, Miami, FL, United States. FAU - Li, Tan AU - Li T AUID- ORCID: 0000-0001-6871-7719 AD - Department of Biostatistics, Stempel College of Public Health, Florida International University, Miami, FL, United States. FAU - Bhat, Anjana AU - Bhat A AUID- ORCID: 0000-0002-0771-0967 AD - Department of Physical Therapy, College of Health Sciences, University of Delaware, Newark, DE, United States. LA - eng GR - U54 MD012393/MD/NIMHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260831 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Adult MH - Pilot Projects MH - Female MH - Feasibility Studies MH - Male MH - Reproducibility of Results MH - Middle Aged MH - *Exercise/physiology MH - Cross-Sectional Studies MH - Adolescent MH - *Autism Spectrum Disorder/physiopathology/psychology MH - Young Adult MH - Quality of Life MH - Surveys and Questionnaires MH - Telemedicine PMC - PMC13575549 OTO - NOTNLM OT - adult autism OT - autism in adulthood OT - autism spectrum disorder OT - co-participation OT - cross-sectional design OT - digital health OT - family support OT - health disparities OT - minority health OT - motor impairments OT - patient-reported outcomes OT - physical activity OT - physical function OT - protocol study OT - rehabilitation OT - remote assessment OT - telehealth OT - wearable devices COIS- Conflicts of Interest: None declared. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 23:43 PMCR- 2026/08/31 CRDT- 2026/08/31 16:53 PHST- 2025/10/16 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/31 23:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 16:53 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - v15i1e86020 [pii] AID - 10.2196/86020 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Aug 31;15:e86020. doi: 10.2196/86020. PMID- 42671537 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260914 IS - 1573-6628 (Electronic) IS - 1092-7875 (Print) IS - 1092-7875 (Linking) VI - 30 IP - 9 DP - 2026 Sep TI - Growing CAPITOL 4 Life: A Case Study of Co-designed Material for the First 1000 Days Using a Modified Double Diamond Approach. PG - 1111-1121 LID - 10.1007/s10995-026-04320-w [doi] AB - INTRODUCTION: Growing CAPITOL 4 Life is a place-based public health initiative focused on the first 1000 days (F1D), from conception to a child's second birthday. It sought to strengthen community capacity for early-childhood health by leveraging local knowledge, assets and partnerships, while moving beyond one-way information provision towards sustained learning, empowerment and collective action. This study retrospectively examined the co-design process through the lens of the Double Diamond. METHODS: Parents, educators, service providers and community stakeholders across Burnie, Circular Head and Devonport, Tasmania, participated in co-design workshops. Engagement spanned government, local government, Aboriginal organizations, libraries and community services. The process was facilitated by a place-based systems-change organization and supported by the University of Tasmania. Community members contributed lived experience alongside professional and academic knowledge, with decision-making remaining largely community-led and guided by the principle of "for the community, by the community." RESULTS: Across the four phases, communities moved from sharing experiences and identifying strengths and challenges (Discover), to refining priorities (Define), developing locally relevant resources and learning approaches (Develop), and shaping feasible delivery models (Deliver). The process centered on the F1D domains of Connection, Nutrition, Caring and Moving and resulted in community-informed Evidence Briefs, workshops and playgroup-based learning. Importantly, the Double Diamond was reflected not as a prescribed sequence, but as a recurring pattern of opening outward to explore and narrowing inward to make sense, prioritize and act. Discussions moved organically between what was working, what was missing, what an ideal future might look like and how communities could move towards it. DISCUSSION: The findings suggest that the value of the Double Diamond in public health lies less in adherence to predefined stages than in providing sufficient structure for purposeful exploration while preserving community agency. This flexible approach may support locally relevant, acceptable and trusted solutions, particularly in complex regional settings where effective public health responses must emerge from, rather than be imposed upon, communities. CI - (c) 2026. The Author(s). FAU - Hills, Andrew P AU - Hills AP AD - School of Health Sciences, UTAS Health, University of Tasmania, Launceston, 7250, Australia. Andrew.hills@utas.edu.au. FAU - Jayasinghe, Sisitha AU - Jayasinghe S AUID- ORCID: 0000-0001-8805-385X AD - Independent Researcher, Newcastle upon Tyne, NE1 8SG, United Kingdom. FAU - Mulcahy, Kylie AU - Mulcahy K AD - Burnie Works, Burnie, TAS, 7320, Australia. FAU - Burgess, Kylie AU - Burgess K AD - Burnie Works, Burnie, TAS, 7320, Australia. FAU - Dalton, Lisa AU - Dalton L AD - School of Health Sciences, UTAS Health, University of Tasmania, Launceston, 7250, Australia. FAU - Ahuja, Kiran D K AU - Ahuja KDK AD - School of Health Sciences, UTAS Health, University of Tasmania, Launceston, 7250, Australia. FAU - Hughes, Roger AU - Hughes R AD - Department of Nursing and Allied Health, Swinburne University of Technology, Hawthorn, Vic, 3122, Australia. FAU - Byrne, Nuala M AU - Byrne NM AD - School of Health Sciences, UTAS Health, University of Tasmania, Launceston, 7250, Australia. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - Matern Child Health J JT - Maternal and child health journal JID - 9715672 SB - IM MH - Humans MH - Tasmania MH - Retrospective Studies MH - *Health Promotion/methods MH - Infant MH - Infant, Newborn MH - *Public Health/methods PMC - PMC13569572 OTO - NOTNLM OT - Co-design OT - Double diamond OT - First 1000 days OT - Health promotion OT - Participatory design COIS- Declarations. Conflict of interest: The authors declare no conflict of interest. Consent to Participate: Both written and verbal consent were obtained from all participants. EDAT- 2026/08/31 19:42 MHDA- 2026/09/11 17:36 PMCR- 2026/08/31 CRDT- 2026/08/31 11:08 PHST- 2025/09/04 00:00 [received] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/11 17:36 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 11:08 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - 10.1007/s10995-026-04320-w [pii] AID - 4320 [pii] AID - 10.1007/s10995-026-04320-w [doi] PST - ppublish SO - Matern Child Health J. 2026 Sep;30(9):1111-1121. doi: 10.1007/s10995-026-04320-w. Epub 2026 Aug 31. PMID- 42671439 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260831 IS - 1119-3077 (Print) VI - 29 IP - 8 DP - 2026 Aug 1 TI - Effect of Immediate versus Early Skin-to-Skin Contact after Cesarean Section on Maternal and Neonatal Outcomes within the First 24 Hours: A Quasi-Experimental Study. PG - 852-863 LID - 10.4103/njcp.njcp_711_25 [doi] AB - BACKGROUND: In Turkiye and moderate-income developing countries, skin-to-skin contact (SSC) is not a routine practice and is often neglected, especially after a cesarean. AIM: The aim of this research was to evaluate the effect of immediate and early SSC after cesarean on maternal and neonatal parameters in the first 24 hours. METHODS: This quasi-experimental clinical study involved 92 mother-neonate pairs. Uninterrupted 40-minute SSC was implemented within the first 5 minutes in the immediate SSC (ISSC) group and within the first hour after cesarean in the early SSC (ESSC) group. Routine care was given to the control group. Data collected with the Infant Breastfeeding Assessment Tool, State Anxiety Inventory and maternal-neonatal monitoring timeline. RESULTS: The maternal anxiety scores and hemorrhage amounts were similar between the groups ( P > 0.05). Breastfeeding initiation in the ISSC group was significantly earlier than in other groups ( P = 0.006). The 24 th -hour breastfeeding scores and body temperature of neonates in the ISSC group were found to be significantly higher than those of the control group ( P = 0.032; P = 0.038, respectively). There were no differences between the neonates in terms of pulse, respiratory rate and peripheral oxygen saturation values, crying, postnatal 2 nd hour blood glucose, weight loss, urine and stool outputs ( P > 0.05). However, those in the ESSC group were determined to sleep significantly longer compared to the control group ( P = 0.014). CONCLUSION: Immediate and uninterrupted 40-minute SSC significantly promoted earlier breastfeeding initiation, improved 24-hour breastfeeding success and neonatal thermoregulation. ESSC has been associated with prolonged sleep duration in newborns. Consequently, SSC is a feasible, low-cost intervention that can be incorporated into routine postnatal care. CI - Copyright (c) 2026 Nigerian Journal of Clinical Practice. FAU - Gurcuoglu, E A AU - Gurcuoglu EA AD - Nursing Department, Faculty of Health Sciences, Cankiri Karatekin University, Cankiri, Turkiye. FAU - Erenel, A S AU - Erenel AS AD - Nursing Department, Faculty of Nursing, Gazi University, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260826 PL - India TA - Niger J Clin Pract JT - Nigerian journal of clinical practice JID - 101150032 SB - IM MH - Humans MH - Female MH - Infant, Newborn MH - Adult MH - *Breast Feeding MH - *Cesarean Section/psychology MH - Pregnancy MH - *Kangaroo-Mother Care Method/methods MH - *Mother-Child Relations/psychology MH - Time Factors MH - *Touch MH - Anxiety MH - Turkey MH - Young Adult OTO - NOTNLM OT - Anxiety OT - breastfeeding OT - early skin-to-skin contact OT - immediate skin-to-skin contact OT - maternal hemorrhage OT - neonate EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 19:43 CRDT- 2026/08/31 11:03 PHST- 2025/10/17 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/08/31 19:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 11:03 [entrez] AID - 01253091-202608000-00004 [pii] AID - 10.4103/njcp.njcp_711_25 [doi] PST - ppublish SO - Niger J Clin Pract. 2026 Aug 1;29(8):852-863. doi: 10.4103/njcp.njcp_711_25. Epub 2026 Aug 26. PMID- 42670969 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260920 IS - 2149-2042 (Print) IS - 2149-4606 (Electronic) IS - 2149-4606 (Linking) VI - 41 IP - 3 DP - 2026 Sep 18 TI - Evaluation of Early Diagnostic Methods for Subclinical Cardiovascular Changes in Childhood Obesity. PG - 296-308 LID - 10.4274/MMJ.galenos.2026.59783 [doi] AB - Childhood obesity is associated with early cardiometabolic abnormalities and subclinical vascular and cardiac changes. This narrative review summarizes the mechanisms underlying these changes and evaluates non-invasive methods used for early detection. PubMed/MEDLINE and Scopus were searched for pediatric studies, systematic reviews, and guidelines, and the principal evidence sources were appraised using design-appropriate tools. Blood pressure measurement, anthropometry, and age-and risk-based laboratory testing remain the basis of routine assessment. Carotid intima-media thickness, pulse wave velocity, endothelial function tests, heart rate variability, advanced echocardiographic measures, and epicardial adipose tissue assessment are promising; however, methodological heterogeneity and limited pediatric reference values restrict most of them to selected clinical or research settings. Standardized longitudinal studies are required to validate thresholds and determine whether test-guided strategies improve outcomes. CI - Copyright(c) 2026 The Author(s). Published by Galenos Publishing House on behalf of Istanbul Medeniyet University Faculty of Medicine. FAU - Badem, Meryem AU - Badem M AUID- ORCID: 0000-0002-6930-2424 AD - Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye. FAU - Hepokur, Merve Nur AU - Hepokur MN AUID- ORCID: 0000-0002-5470-1254 AD - Marmara University Pendik Training and Research Hospital, Department of Pediatric Cardiology, Istanbul, Turkiye. FAU - Karagozlu, Selen AU - Karagozlu S AUID- ORCID: 0000-0002-9542-1937 AD - Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye. FAU - Emeksiz, Hamdi Cihan AU - Emeksiz HC AUID- ORCID: 0000-0002-4815-1591 AD - Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260831 PL - Turkey TA - Medeni Med J JT - Medeniyet medical journal JID - 101676811 PMC - PMC13586907 OTO - NOTNLM OT - Pediatric obesity OT - atherosclerosis OT - cardiovascular diagnostic techniques OT - cardiovascular diseases COIS- The authors declare that they have no conflict of interest related to this study. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 19:43 PMCR- 2026/09/18 CRDT- 2026/08/31 07:12 PHST- 2026/08/31 19:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 07:12 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.4274/MMJ.galenos.2026.59783 [doi] PST - ppublish SO - Medeni Med J. 2026 Sep 18;41(3):296-308. doi: 10.4274/MMJ.galenos.2026.59783. Epub 2026 Aug 31. PMID- 42670657 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260903 IS - 1745-5065 (Electronic) IS - 1745-5057 (Print) IS - 1745-5057 (Linking) VI - 22 DP - 2026 Jan-Dec TI - To what extent does the adapted Women's empowerment in nutrition index demonstrate psychometric validity and determine the nutritional empowerment among pregnant women in southern Ethiopia? PG - 17455057261484831 LID - 10.1177/17455057261484831 [doi] LID - 17455057261484831 AB - BackgroundWomen's empowerment plays a crucial role in the wellbeing of families by affecting nutrition and health. Women's Empowerment in Nutrition Index (WENI) was recently developed in rural South Asia, but requires validation in new contexts.ObjectiveThe study aimed to evaluate the psychometric validation of the WENI, the level of nutritional empowerment and factors associated with nutritional empowerment among pregnant women in Southern Ethiopia.DesignA facility-based cross-sectional study design was employed.MethodsThe study was conducted among 392 pregnant women from March 10 to May 30, 2025. The structural validity of the WENI was assessed using Exploratory and Confirmatory Factor Analysis (EFA/CFA) to identify latent constructs of empowerment. Kaiser-Meyer-Olkin (>/= 0.60) and significant results in Bartlett's Test (p < 0.05) were used for confirming sampling adequacy. Independent factors were identified using a hierarchical negative binomial multiple regression with adjusted incidence rate ratios (aIRRs) calculated, considering statistical significance at p < 0.05.ResultsFactor analysis revealed a six-factor structure with an internal consistency (Cronbach's alpha = 0.86), and convergent and discriminant validities (AVE=0.50, CR=0.70). The model demonstrated strong fit indices (CFI= 0.94; RMSEA<0.06). A significant relationship was found between WENI scores and maternal and child nutrition outcomes (p<0.001), with 51.5% of women being nutritionally empowered. Empowerment was higher in women free from intimate partner violence (aIRR = 1.12), those receiving nutritional counseling (aIRR = 1.33). Conversely, empowerment rates were lower in women with no formal education (aIRR = 0.76) and those in the lowest wealth quintile (aIRR = 0.82).ConclusionThis study confirmed that nutritional empowerment, measured via a 21-item tool, improves maternal health and food security. However, social norms and a "knowledge-agency gap" persist. Interventions must shift from basic education to actively promoting women's control over resources, gender equality, and stronger community-based support systems to be truly effective. FAU - Fikrie, Anteneh AU - Fikrie A AUID- ORCID: 0000-0002-9809-3326 AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Wodessa, Gelgelo AU - Wodessa G AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Gelchu, Miesa AU - Gelchu M AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Jofa, Bekam Yambo AU - Jofa BY AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Hailu, Dejene AU - Hailu D AD - School of Public Health, Hawassa University College of Medicine and Health Sciences, Awassa, Ethiopia. RINGGOLD: 293657 FAU - Abera, Mubarek AU - Abera M AD - Department of Psychiatry, Faculty of Medical Science, Jimma University, Jimma, Oromia, Ethiopia. RINGGOLD: 107839 FAU - Spigt, Mark AU - Spigt M AD - Department of Family Medicine, Universiteit Maastricht Care and Public Health Research Institute, Maastricht, Netherlands. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - Womens Health (Lond) JT - Women's health (London, England) JID - 101271249 SB - IM MH - Humans MH - Female MH - Ethiopia MH - *Psychometrics MH - Cross-Sectional Studies MH - *Empowerment MH - Adult MH - Pregnancy MH - *Pregnant People/psychology MH - Reproducibility of Results MH - *Nutritional Status MH - Surveys and Questionnaires/standards MH - Young Adult MH - *Power, Psychological MH - Rural Population PMC - PMC13530473 OAB - This study assessed how to measure nutritional empowerment, woman ability to make decisions that impact the health and nutrition of herself and her family's among 392 pregnant women in Southern Ethiopia. By using a 21-item tool called the Women's Empowerment in Nutrition Index (WENI), researchers confirmed that the survey is an accurate and reliable way to measure these capabilities in the region. The findings showed that about 51.5% of the women surveyed were nutritionally empowered, a status that was directly linked to better overall health outcomes for both mothers and children. The study identified clear factors that influence whether a woman can exercise this control. Women were significantly more likely to be empowered if they received nutritional counselling or lived in households free from intimate partner violence. Conversely, empowerment was lower among women who had no formal education or lived in the lowest income households. Ultimately, the researchers concluded that while nutritional knowledge is important, it is not enough on its own. To bridge the gap between knowing about health and having the agency to act on it, future interventions must shift focus toward promoting gender equality, securing women control over household resources, and strengthening community-based support systems. OABL- eng OTO - NOTNLM OT - factor analysis OT - pregnant women OT - psychometric validation OT - women's empowerment COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 19:43 PMCR- 2026/08/31 CRDT- 2026/08/31 04:33 PHST- 2026/08/31 19:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 04:33 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - 10.1177_17455057261484831 [pii] AID - 10.1177/17455057261484831 [doi] PST - ppublish SO - Womens Health (Lond). 2026 Jan-Dec;22:17455057261484831. doi: 10.1177/17455057261484831. Epub 2026 Aug 31. PMID- 42670279 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 83 IP - 4 DP - 2026 Oct TI - Mid-upper arm circumference, steatosis indices, and elastography for screening liver steatosis in children with overweight/obesity: A prospective cross-sectional study. PG - 616-623 LID - 10.1002/jpn3.70554 [doi] AB - OBJECTIVES: Metabolic dysfunction-associated steatotic liver disease (MASLD) is common in children, and practical screening approaches are needed in populations with overweight/obesity. We aimed to evaluate mid-upper arm circumference (MUAC) as a simple marker for ultrasonography (US)-detected liver steatosis (LS) in children with overweight/obesity, to examine the performance of other non-invasive measures, and to assess MUAC-based composite cut-offs. METHODS: In this study, 194 children with overweight/obesity aged 5-17 years were evaluated at a pediatric gastroenterology clinic. US-detected LS was defined as US grade >/=1. Liver stiffness was measured by two-dimensional shear-wave elastography (2D-SWE). Fasting biochemistry was obtained, and alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio, Hepatic Steatosis Index, and Framingham Steatosis Index were calculated. Associations between US-detected LS and anthropometric, biochemical, and liver stiffness measures were assessed using Spearman correlation, logistic regression, and receiver operating characteristic analyses; composite models used an odds ratio-rule approach. RESULTS: US-detected LS was present in 55.2%. MUAC >/= 30.0 cm yielded an area under the curve (AUC) of 0.738 for identifying US-detected LS. A composite rule of body mass index (BMI) z score >/=1.70 or MUAC >/= 30.0 cm achieved 97.2% sensitivity and 54.0% specificity for identifying US-detected LS, with an AUC of 0.813, negative predictive value 94.0%, and positive predictive value 72.2%. Adding liver stiffness >/=5.68 kPa increased discrimination for identifying US-detected LS, with an AUC of 0.881. CONCLUSION: MUAC is a low-cost adjunct for screening US-detected LS in children with overweight/obesity. Simple composite cut-offs integrating MUAC with BMI showed high sensitivity in this cohort and may support initial risk stratification before ultrasonographic evaluation; adding liver stiffness yielded the highest discriminative performance. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Teke, Selcuk AU - Teke S AUID- ORCID: 0000-0002-1885-6611 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Cavis, Tugba AU - Cavis T AUID- ORCID: 0000-0001-8878-9568 AD - Department of Radiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Ergen, Yasin Maruf AU - Ergen YM AUID- ORCID: 0000-0002-3689-6852 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Akcay, Birce Izgi AU - Akcay BI AUID- ORCID: 0000-0002-1325-0899 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Basaran, Edibe Gozde AU - Basaran EG AUID- ORCID: 0000-0003-3165-3234 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Balamtekin, Necati AU - Balamtekin N AUID- ORCID: 0000-0001-8665-5611 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. LA - eng GR - None/ PT - Journal Article DEP - 20260831 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - Child MH - *Elasticity Imaging Techniques/methods MH - Male MH - Female MH - Adolescent MH - Prospective Studies MH - Cross-Sectional Studies MH - Child, Preschool MH - *Fatty Liver/diagnosis/etiology/diagnostic imaging MH - *Arm/anatomy & histology MH - *Pediatric Obesity/complications MH - *Overweight/complications MH - Liver/diagnostic imaging/pathology MH - Body Mass Index MH - ROC Curve MH - Mass Screening/methods MH - Sensitivity and Specificity MH - Anthropometry PMC - PMC13646030 OTO - NOTNLM OT - Framingham Steatosis Index OT - Hepatic Steatosis Index OT - body mass index OT - elasticity imaging techniques OT - fatty liver COIS- The authors declare no conflict of interest. EDAT- 2026/08/31 19:42 MHDA- 2026/10/08 05:31 PMCR- 2026/10/08 CRDT- 2026/08/31 03:23 PHST- 2026/07/22 00:00 [revised] PHST- 2026/03/17 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 03:23 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - JPN370554 [pii] AID - 10.1002/jpn3.70554 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Oct;83(4):616-623. doi: 10.1002/jpn3.70554. Epub 2026 Aug 31. PMID- 42670172 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260902 IS - 2057-4347 (Electronic) IS - 2057-4347 (Linking) VI - 12 IP - 5 DP - 2026 Oct TI - Machine Learning Prediction of Anterior Open-Bite Development After Stabilization Splint Treatment in Temporomandibular Disorder. PG - e70447 LID - 10.1002/cre2.70447 [doi] LID - e70447 AB - OBJECTIVES: To develop interpretable machine learning (ML) models for risk stratification of clinically meaningful anterior overbite decrease after stabilization splint therapy in temporomandibular disorder (TMD) patients, and to compare ML performance with conventional logistic regression. MATERIALS AND METHODS: This retrospective cohort included 87 TMD patients treated with stabilization splints, physical therapy, and pharmacologic therapy. Thirty-five pre-treatment cephalometric and demographic features were used. The primary outcome was overbite difference (OD = post-treatment minus pre-treatment overbite). For classification, patients were labeled as Decrease (OD < -0.5 mm; n = 37) versus Non-Decrease (OD >/= -0.5 mm; n = 50), combining No Change and Increase due to severe imbalance in the Increase subgroup. Six classifiers (logistic regression, random forest, extreme gradient boosting (XGBoost), Light Gradient Boosting Machine, support vector machine, k-nearest neighbors) were evaluated using stratified fivefold cross-validation and leave-one-out cross-validation. Class imbalance was handled using class-weighting and the Synthetic Minority Over-sampling Technique (SMOTE) applied within the cross-validation loop. For regression, nine algorithms were tested to predict continuous OD. Model explainability was assessed using SHapley Additive exPlanations (SHAP). RESULTS: In fivefold cross-validation, XGBoost achieved the best discrimination (AUC = 0.734), outperforming logistic regression (AUC = 0.611). With SMOTE, the random forest achieved a comparable AUC (0.735) with improved sensitivity. Across regression models, cross-validated R(2) values were near-zero or negative, indicating limited ability to predict the exact magnitude of overbite change from baseline variables alone. SHAP ranked pre-treatment overbite, ramus height, upper occlusal plane to SN angle, sella-to-condylion distance, and condylar positional indices among the most influential predictors for classification. CONCLUSION: Interpretable ML enables improved risk stratification for clinically meaningful anterior overbite decrease after stabilization splint therapy in TMD patients, whereas predicting the exact magnitude of overbite change remains limited using pre-treatment cephalometrics alone. These models may support individualized counseling and closer monitoring for patients at higher risk of open-bite development during splint therapy. CI - (c) 2026 The Author(s). Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. FAU - Hwang, Jae Joon AU - Hwang JJ AUID- ORCID: 0000-0003-0379-8460 AD - Department of Oral and Maxillofacial Radiology, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. FAU - Jeon, Hye-Mi AU - Jeon HM AUID- ORCID: 0000-0003-0007-5662 AD - Department of Oral Medicine, Pusan National University Hospital, Busan, Republic of Korea. AD - Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. FAU - Ju, Hye-Min AU - Ju HM AUID- ORCID: 0000-0002-9252-6717 AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. AD - Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. FAU - Jeong, Sung-Hee AU - Jeong SH AUID- ORCID: 0000-0002-6296-4775 AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. AD - Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. FAU - Ahn, Yong-Woo AU - Ahn YW AUID- ORCID: 0000-0002-2197-0394 AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. AD - Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. FAU - Ok, Soo-Min AU - Ok SM AUID- ORCID: 0000-0003-1776-371X AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. AD - Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. LA - eng GR - RS-2025-20082969/National Research Foundation of Korea/ GR - RS-2023-00217689/National Research Foundation of Korea/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Exp Dent Res JT - Clinical and experimental dental research JID - 101692332 SB - IM MH - Humans MH - Retrospective Studies MH - *Temporomandibular Joint Disorders/therapy/complications MH - *Machine Learning MH - Female MH - Predictive Learning Models MH - Boosting Machine Learning Algorithms MH - Random Forest MH - *Open Bite/etiology/diagnosis MH - *Occlusal Splints MH - Classification Algorithms MH - Prediction Algorithms MH - Logistic Models MH - Cephalometry MH - Adult MH - Young Adult MH - Adolescent MH - Risk Assessment/methods PMC - PMC13527398 OTO - NOTNLM OT - machine learning OT - occlusal splint OT - open-bite OT - temporomandibular disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 19:43 PMCR- 2026/08/30 CRDT- 2026/08/31 02:02 PHST- 2026/08/11 00:00 [revised] PHST- 2026/02/28 00:00 [received] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/31 19:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 02:02 [entrez] PHST- 2026/08/30 00:00 [pmc-release] AID - CRE270447 [pii] AID - 10.1002/cre2.70447 [doi] PST - ppublish SO - Clin Exp Dent Res. 2026 Oct;12(5):e70447. doi: 10.1002/cre2.70447. PMID- 42669612 OWN - NLM STAT- Publisher LR - 20260830 IS - 1939-3806 (Electronic) IS - 1939-3806 (Linking) DP - 2026 Aug 30 TI - Interval-Based Aerobic Exercise and Behavioral Intervention for Sleep Disturbances in Children With Autism Spectrum Disorder: A Randomized Controlled Trial. PG - e70361 LID - 10.1002/aur.70361 [doi] AB - Sleep disturbances affect 40%-80% of children with autism spectrum disorder (ASD) and are associated with impaired attention and daytime functioning. We conducted a preliminary randomized controlled trial to evaluate the effects of a short-term interval-based aerobic exercise combined with parent behavioral education (IAE-PBE) program on sleep and related outcomes in children with ASD and sleep disturbances. Twenty-eight children were randomly assigned to either the IAE-PBE group or the parent behavioral education (PBE)-only group for a 2-week intervention. Sleep was assessed using actigraphy, and attention was evaluated using age-appropriate Conners' Continuous Performance Tests. The primary outcome was sleep efficiency. Secondary outcomes included caregiver-reported sleep disturbances, attention, autism-related symptoms, and adaptive behavior. Compared with the PBE-only group, the IAE-PBE group showed greater improvement in sleep efficiency (group x time interaction, p = 0.035; within-group p = 0.026, Hedges' g = 0.89). Significant group x time interactions were also found for caregiver-reported sleep disturbances (p = 0.003) and perseverative responses on the attention test (p < 0.001), with greater improvements in the IAE-PBE group. Favorable changes were also observed in autism-related symptoms, whereas adaptive behavior did not differ between groups. These preliminary findings suggest that a short-term interval-based aerobic exercise program combined with parent behavioral education is feasible and may improve objectively measured sleep efficiency while also providing benefits for attention in children with ASD. Further studies with larger samples and longer follow-up are needed to confirm these findings. Trial Registration: ClinicalTrials.gov identifier: NCT07381504. CI - (c) 2026 International Society for Autism Research and Wiley Periodicals LLC. FAU - Lu, Pin-Tzu AU - Lu PT AUID- ORCID: 0009-0008-7885-4176 AD - School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan. FAU - Yang, Chieh-Yu AU - Yang CY AUID- ORCID: 0009-0000-3157-8225 AD - School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan. FAU - Huang, Fang-Yi AU - Huang FY AUID- ORCID: 0009-0002-2266-883X AD - Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan. FAU - Chen, Ying-Chun AU - Chen YC AUID- ORCID: 0000-0001-5764-9706 AD - Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan. AD - Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan. FAU - Chang, Jung-Chi AU - Chang JC AD - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. AD - Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan. FAU - Cheong, Pou-Leng AU - Cheong PL AUID- ORCID: 0009-0003-4896-1468 AD - Department of Pediatrics, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan. FAU - Wu, Yen-Tzu AU - Wu YT AUID- ORCID: 0000-0001-5035-4577 AD - School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan. AD - Physical Therapy Center, National Taiwan University Hospital, Taipei, Taiwan. LA - eng SI - ClinicalTrials.gov/NCT07381504 GR - NTUH 114-S0131/National Taiwan University Hospital/ GR - The International Organisation of Physiotherapists in Paediatrics Research/ PT - Journal Article DEP - 20260830 PL - United States TA - Autism Res JT - Autism research : official journal of the International Society for Autism Research JID - 101461858 SB - IM OTO - NOTNLM OT - aerobic exercise OT - attention OT - autism spectrum disorder OT - behavioral intervention OT - sleep disturbances EDAT- 2026/08/30 23:36 MHDA- 2026/08/30 23:36 CRDT- 2026/08/30 22:33 PHST- 2026/08/15 00:00 [revised] PHST- 2026/05/25 00:00 [received] PHST- 2026/08/22 00:00 [accepted] PHST- 2026/08/30 23:36 [medline] PHST- 2026/08/30 23:36 [pubmed] PHST- 2026/08/30 22:33 [entrez] AID - 10.1002/aur.70361 [doi] PST - aheadofprint SO - Autism Res. 2026 Aug 30:e70361. doi: 10.1002/aur.70361. PMID- 42669329 OWN - NLM STAT- Publisher LR - 20261001 IS - 2589-5559 (Electronic) IS - 2589-5559 (Linking) DP - 2026 Aug 30 TI - Clinical and Metabolomic Panel for Noninvasive Screening of Biopsy-Confirmed MASH in Children and Adolescents. PG - 102016 LID - S2589-5559(26)00287-9 [pii] LID - 10.1016/j.jhepr.2026.102016 [doi] AB - BACKGROUND & AIMS: Noninvasive tests to identify pediatric metabolic dysfunction-associated steatohepatitis (MASH) remain a critical need. We aimed to develop and validate a screening panel that identifies biopsy-confirmed MASH in children and adolescents using clinical and metabolomics data. METHODS: Fasting serum from youth in NASH CRN studies and healthy participants underwent untargeted metabolomics by liquid chromatography-mass spectrometry (LC-MS). Clinical data included anthropometrics, lipids, liver enzymes, and markers of insulin resistance. MASH was determined by biopsy in NASH CRN participants and hepatic steatosis by MRI-PDFF in healthy participants. Clinical features were selected by Kolmogorov-Smirnov testing (p < 0.05), and metabolomics data were reduced to 52 features with non-zero LASSO coefficients. Feature importance was ranked using CatBoost. The final model included eight clinical features and the top 10 annotated metabolites. Data were split into training and test sets, with longitudinal validation in a sub-cohort with 96-week follow-up biopsies. RESULTS: The cohort included 586 children (ages 5-18, 70% male, mean BMI z-score of 2.35 +/- 0.84, 72% Hispanic). Of these, 390 had MASH (21% Zone 3, 41% Zone 1, 38% definite MASH), and 196 were non-MASH. The model incorporated ALT, AST, GGT, platelets, HOMA-IR, BMI z-score, TG:HDL ratio, and alkaline phosphatase. Key metabolic features included amino acid derivatives (e.g., glutamic acid, argininosuccinic acid), indole, diacetylspermine, and lipid metabolites. The model achieved an AUROC of 0.88 (92% sensitivity, 71% specificity) in the test set and 0.81 (69% sensitivity, 86% specificity) in the longitudinal cohort. CONCLUSIONS: This 18-variable panel of eight clinical measures and 10 metabolites showed strong performance for noninvasive screening of biopsy-confirmed MASH in children and potential utility for longitudinal monitoring. IMPACT AND IMPLICATIONS: Currently, there are no clinically approved non-invasive biomarkers for diagnosing or monitoring pediatric MASH, despite its growing prevalence and long-term health risks. This study developed and validated a machine-learning-based panel that combines clinical and high-resolution metabolomics data, demonstrating strong performance for classifying MASH and monitoring disease status in a longitudinal cohort. These findings are particularly relevant for improving the care of children with MASH and could inform both clinical practice and research. With further validation, this approach could reduce reliance on liver biopsy, enable earlier detection, and support clinical decision-making for physicians and researchers. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Huneault, Helaina E AU - Huneault HE AD - Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA. Electronic address: hhuneau@emory.edu. FAU - Sudhakar, Shrramana Ganesh AU - Sudhakar SG AD - School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA. FAU - Gent, Alasdair E AU - Gent AE AD - Department of Surgery, Duke University School of Medicine, Durham, NC, USA; Department of Anesthesiology, Duke University, Durham, NC, USA. FAU - Jarrell, Zachery R AU - Jarrell ZR AD - Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA, USA. FAU - Smith, Matthew Ryan AU - Smith MR AD - Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA, USA; VA Healthcare System of Atlanta, Decatur, GA, USA. FAU - Sanchez-Torres, Cristian AU - Sanchez-Torres C AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA. FAU - Jain, Ajay K AU - Jain AK AD - Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, USA. FAU - Yates, Katherine P AU - Yates KP AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Neuschwander-Tetri, Brent A AU - Neuschwander-Tetri BA AD - Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, USA. FAU - Schwimmer, Jeffrey B AU - Schwimmer JB AD - Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA, USA; Department of Pediatrics, School of Medicine, University of California, San Diego, CA, USA. FAU - Xanthakos, Stavra A AU - Xanthakos SA AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Molleston, Jean P AU - Molleston JP AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Riley Children's Health, Indianapolis, IN, USA. FAU - Behling, Cynthia A AU - Behling CA AD - Sharp Memorial Hospital, San Diego, California, USA. FAU - Fishbein, Mark H AU - Fishbein MH AD - Department of Pediatrics, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA. FAU - Kamaleswaran, Rishikesan AU - Kamaleswaran R AD - Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Surgery, Duke University School of Medicine, Durham, NC, USA; Department of Anesthesiology, Duke University, Durham, NC, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA. FAU - Vos, Miriam B AU - Vos MB AD - Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA; Helen DeVos Children's Hospital, Corewell Health, Grand Rapids, MI, USA. LA - eng PT - Journal Article DEP - 20260830 PL - Netherlands TA - JHEP Rep JT - JHEP reports : innovation in hepatology JID - 101761237 SB - IM OTO - NOTNLM OT - MASLD OT - biomarker discovery OT - gradient boosting OT - histology COIS- Conflicts of interest MBV serves as a consultant to Boehringer Ingelheim, Novo Nordisk, Eli Lilly, Intercept, Takeda, and Alberio. She has stock or stock options in Thiogenesis and Tern Pharmaceuticals. Her institution has received research grants (or in-kind research services) from Target Real World Evidence, Quest, Labcorp, and Sonic Incytes Medical Corp. JPM has research grant funding from Gilead, Abbvie, Albireo, and Mirum. BANT: Advisor or consultant: Abbvie, Akero, Aldeyra, Aligos, Arrowhead, Corcept, Galectin, GSK, Hepion, HistoIndex, Madrigal, Merck, Mirum, Pfizer, Sagimet, Senseion; Stock options: HepGene, HeptaBio; Institutional research grants: Madrigal. SAX: Institutional research grants: Target Real World Evidence. EDAT- 2026/08/30 23:36 MHDA- 2026/08/30 23:36 CRDT- 2026/08/30 19:10 PHST- 2026/03/04 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/08/30 23:36 [pubmed] PHST- 2026/08/30 23:36 [medline] PHST- 2026/08/30 19:10 [entrez] AID - S2589-5559(26)00287-9 [pii] AID - 10.1016/j.jhepr.2026.102016 [doi] PST - aheadofprint SO - JHEP Rep. 2026 Aug 30:102016. doi: 10.1016/j.jhepr.2026.102016. PMID- 42668482 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260830 LR - 20260831 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 10 IP - 9 DP - 2026 Sep TI - The Weight of Responsibilities: Time in Responsibilities and in Food Preparation. PG - 109504 LID - 10.1016/j.cdnut.2026.109504 [doi] LID - 109504 AB - BACKGROUND: The 2025-2030 Dietary Guidelines for Americans emphasize whole, minimally processed foods. However, the time required to prepare these foods may present a barrier. There is limited research on how other responsibilities shape food preparation activities. OBJECTIVES: The objective of this study was to identify the daily life activities that adults in the United States consider responsibilities and evaluate the association between the amount of time spent on responsibilities and food preparation activities. METHODS: Using data from a national survey among United States adults, we identified which activities adults consider responsibilities. We used the American Time Use Survey and the Eating and Health Module data from 2014-2016 and 2022-2023 to examine the relationship between time spent on responsibilities and food preparation in the pooled sample and stratified by household composition. RESULTS: Households with children spent the most time in responsibilities and food preparation, with single-parent households spending less time in food preparation than dual-parent households. The estimated association between time in responsibilities and food preparation was small but significant and negative in the pooled sample and across household composition subgroups. CONCLUSIONS: The marginal association between responsibilities and food preparation time is small, suggesting that households largely protect food preparation time as responsibilities increase. However, cumulative effects across realistic variation in responsibilities are nontrivial (representing 5 mL/kg), intra-abdominal pressure gradations, and feeding intolerance definitions. Higher AGI severity is consistently associated with increased mortality, prolonged mechanical ventilation, and greater multiple organ dysfunction syndrome. Synthesis of AGI severity concepts with pediatric nutrition guidelines suggests that early enteral nutrition appears feasible in mild dysfunction, whereas severe grades may warrant cautious parenteral supplementation with dynamic reassessment. This review identifies critical gaps: the absence of multicenter validation, the subjective nature of grading variables, and the lack of age-stratified nutritional trials. In conclusion, AGI severity assessment holds conceptual promise for risk stratification and nutritional guidance in pediatric intensive care, but requires formal consensus methodology, systematic evidence synthesis, and prospective validation before clinical adoption. CI - Copyright (c) 2026 Zeng, Li, Wu, Rong, Liu, Chen, Cai, Zhang, Li and Liu. FAU - Zeng, Cizheng AU - Zeng C AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Li, Tufeng AU - Li T AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Wu, Jiayuan AU - Wu J AD - Department of Scientific Research, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Rong, Shiwen AU - Rong S AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Liu, Xiaohua AU - Liu X AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Chen, Yinhui AU - Chen Y AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Cai, Nali AU - Cai N AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Zhang, Limei AU - Zhang L AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Li, Wen AU - Li W AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Liu, Ling AU - Liu L AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. LA - eng PT - Journal Article PT - Review DEP - 20260814 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 EIN - Front Nutr. 2026 Sep 23;13:1989398. doi: 10.3389/fnut.2026.1989398. PMID: 42846160 PMC - PMC13521867 OTO - NOTNLM OT - critical illness OT - enteral feeding OT - feeding intolerance OT - gastric residual volume OT - intra-abdominal hypertension OT - multiple organ dysfunction OT - nutritional support OT - pediatric intensive care COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/29 05:35 MHDA- 2026/08/29 05:36 PMCR- 2026/08/14 CRDT- 2026/08/29 04:39 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/24 00:00 [accepted] PHST- 2026/08/29 05:36 [medline] PHST- 2026/08/29 05:35 [pubmed] PHST- 2026/08/29 04:39 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 10.3389/fnut.2026.1911973 [doi] PST - epublish SO - Front Nutr. 2026 Aug 14;13:1911973. doi: 10.3389/fnut.2026.1911973. eCollection 2026. PMID- 42666156 OWN - NLM STAT- MEDLINE DCOM- 20260829 LR - 20260908 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Scale-up of the Diactive-1 mHealth program integrating tailored resistance training as an educational strategy for self-management in children and adolescents with type 1 diabetes: protocol for an 11-hospital multicenter randomized controlled trial. PG - 1913568 LID - 10.3389/fendo.2026.1913568 [doi] LID - 1913568 AB - INTRODUCTION: Physical activity is strongly recommended for youth with type 1 diabetes, yet many children and adolescents do not meet current exercise guidelines, partly because of fear of hypoglycemia. Resistance training may offer metabolic and musculoskeletal benefits, but its implementation in routine pediatric diabetes care remains limited. Diactive-1 is an mHealth program designed to deliver tailored resistance-training sessions combined with glucose-management educational support. This multicenter trial aims to evaluate the effectiveness of Diactive-1 (v2.0) in improving hangrip strength in children and adolescents with type 1 diabetes. METHODS: This study is a 12-week, parallel-group, multicenter randomized controlled trial conducted across 11 Spanish pediatric endocrinology units. The target sample size is 158 children and adolescents aged 10-18 years with type 1 diabetes, with 79 participants allocated to each group. Participants will be randomized to either the Diactive-1 intervention or usual clinical care. The intervention group will use the Diactive-1 (v2.0) app, which provides individualized resistance-training programs, glucose-related educational prompts, safety thresholds for exercise, and engagement strategies such as gamification. The primary outcome will be the change in age- and sex-standardized handgrip strength z-score from baseline to 12 weeks. Secondary outcomes will include glycemic stability, insulin requirements, cardiometabolic markers, physical literacy, quality of life, psychological well-being, app usability, and intervention engagement. Analyses will follow the intention-to-treat principle using mixed-effects models. EXPECTED OUTCOMES AND DISCUSSION: This trial will assess whether a scalable mHealth-supported resistance-training program can improve muscular strength and support diabetes self-management in routine pediatric care. By testing Diactive-1 across multiple hospitals and real-world settings, the study will provide evidence on the external validity, feasibility, and potential clinical integration of digitally supported exercise education for youth with type 1 diabetes. ETHICS AND DISSEMINATION: Ethical approval was granted by the Research Ethics Committee for Medicinal Products of the Government of Navarra. Written informed consent will be obtained from parents or legal guardians, with age-appropriate assent from minors. Findings will be disseminated through scientific conferences, peer-reviewed publications, and summaries shared with participating families. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT07290868, identifier NCT07290868. CI - Copyright (c) 2026 Sanchez-Arlegui, Munoz-Pardeza, Hormazabal-Aguayo, Abio-Abero, Bertholt-Zuber, Alonso-Rubio, Burillo-Sanchez, Chueca-Guindulain, Cifuentes-Zamalloa, Congost-Marin, Diez-Lopez, Ferrer-Lozano, Garcia-Navas, Gonzalez-Garcia, Huidobro-Fernandez, Lalaguna-Mallada, Llorente-Cereza, Maeso-Mendez, Riano-Galan, Ruiz-del Campo, Salcedo Fresneda, Vara-Callau, Vela-Desojo, Ezzatvar and Garcia-Hermoso. FAU - Sanchez-Arlegui, Amaia AU - Sanchez-Arlegui A AD - Public Healthcare Service of Navarra-Osasunbidea (SNS-O), Universidad Publica de Navarra (UPNA), Pamplona, Spain. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Hormazabal-Aguayo, Ignacio AU - Hormazabal-Aguayo I AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. AD - Office of the Vice-Rector for Research and Graduate Studies, Universidad de La Serena, La Serena, Chile. FAU - Abio-Abero, Sonia AU - Abio-Abero S AD - Pediatrics Service, Hospital San Jorge, Huesca, Spain. FAU - Bertholt-Zuber, Maria Laura AU - Bertholt-Zuber ML AD - Pediatric Endocrinology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain. FAU - Alonso-Rubio, Pablo AU - Alonso-Rubio P AD - Pediatric Endocrinology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain. FAU - Burillo-Sanchez, Elisabet AU - Burillo-Sanchez E AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Chueca-Guindulain, Maria J AU - Chueca-Guindulain MJ AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Cifuentes-Zamalloa, Claudia AU - Cifuentes-Zamalloa C AD - Pediatric Endocrinology Unit, Hospital Universitario Cruces, Barakaldo, Spain. FAU - Congost-Marin, Sofia AU - Congost-Marin S AD - Pediatric Endocrinology Unit, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain. FAU - Diez-Lopez, Ignacio AU - Diez-Lopez I AD - Pediatrics Service, Hospital de Araba, Vitoria, Spain. FAU - Ferrer-Lozano, Marta AU - Ferrer-Lozano M AD - Pediatric Endocrinology Unit, Hospital Infantil Miguel Servet, Zaragoza, Spain. FAU - Garcia-Navas, Patricia AU - Garcia-Navas P AD - Pediatrics Service, Hospital San Pedro, Logrono, Spain. FAU - Gonzalez-Garcia, Lara Gloria AU - Gonzalez-Garcia LG AD - Pediatrics Service, Hospital de Cabuenes, Gijon, Spain. FAU - Huidobro-Fernandez, Belen AU - Huidobro-Fernandez B AD - Pediatrics Service, Hospital de Cabuenes, Gijon, Spain. FAU - Lalaguna-Mallada, Paula AU - Lalaguna-Mallada P AD - Pediatrics Service, Hospital de Barbastro, Huesca, Spain. FAU - Llorente-Cereza, Maria Teresa AU - Llorente-Cereza MT AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Maeso-Mendez, Sandra AU - Maeso-Mendez S AD - Pediatrics Service, Hospital de Araba, Vitoria, Spain. FAU - Riano-Galan, Isolina AU - Riano-Galan I AD - Pediatric Endocrinology Unit, Hospital Universitario Central de Asturias, Oviedo, Spain. FAU - Ruiz-Del Campo, Maria AU - Ruiz-Del Campo M AD - Pediatrics Service, Hospital San Pedro, Logrono, Spain. FAU - Salcedo Fresneda, Oihane AU - Salcedo Fresneda O AD - Pediatric Endocrinology Unit, Hospital Universitario Central de Asturias, Oviedo, Spain. FAU - Vara-Callau, Marta AU - Vara-Callau M AD - Pediatric Endocrinology Unit, Hospital Infantil Miguel Servet, Zaragoza, Spain. FAU - Vela-Desojo, Amaia AU - Vela-Desojo A AD - Pediatric Endocrinology Unit, Hospital Universitario Cruces, Barakaldo, Spain. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AD - Lifestyle factors with impact on Ageing and overall Health (LAH) Research Group, Departamento de Enfermeria, Universidad de Valencia, Valencia, Spain. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Garcia-Hermoso, Antonio AU - Garcia-Hermoso A AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. LA - eng SI - ClinicalTrials.gov/NCT07290868 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260814 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/therapy MH - Child MH - Adolescent MH - *Resistance Training/methods MH - Multicenter Studies as Topic MH - Female MH - *Self-Management/education/methods MH - Male MH - Randomized Controlled Trials as Topic MH - *Patient Education as Topic/methods MH - Telemedicine MH - Quality of Life PMC - PMC13521802 OTO - NOTNLM OT - digital health OT - education OT - mHealth OT - strength training OT - type 1 diabetes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/29 05:35 MHDA- 2026/08/29 05:36 PMCR- 2026/08/14 CRDT- 2026/08/29 04:31 PHST- 2026/06/19 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/29 05:36 [medline] PHST- 2026/08/29 05:35 [pubmed] PHST- 2026/08/29 04:31 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 10.3389/fendo.2026.1913568 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 14;17:1913568. doi: 10.3389/fendo.2026.1913568. eCollection 2026. PMID- 42665290 OWN - NLM STAT- Publisher LR - 20260828 IS - 1552-6127 (Electronic) IS - 1090-1981 (Linking) DP - 2026 Aug 28 TI - A Therapeutic Exercise Programme for Trans and Gender Diverse Youth: An Effectiveness-Implementation Trial. PG - 10901981261479283 LID - 10.1177/10901981261479283 [doi] AB - Trans young people face systemic barriers to physical activity participation and experience disproportionately higher rates of physical and mental health challenges compared with their cisgender peers, yet evidence-based exercise interventions tailored to this population remain limited. This study evaluated a 12-week structured, group-based, gender-affirming exercise programme for trans youth aged 12 to 24 years in Western Australia, recruited through a specialist paediatric gender diversity service and community-based health and well-being services. Using a nonrandomised effectiveness-implementation hybrid design, the study assessed both the real-world implementation outcomes and health-related effectiveness of the programme, which was collaboratively designed with trans young people, families, and health professionals and grounded in international physical activity guidelines. Twenty participants enrolled, with 18 completing postprogramme assessments. Quantitative analysis revealed modest improvements in muscular strength, endurance, power, aerobic recovery, and well-being from baseline to 12 weeks, alongside high acceptability, appropriateness, feasibility, fidelity, and retention rates. Qualitative analysis identified themes relating to pathways to participation, connection through shared experience, supportive facilitation, and perceived physical and psychological benefits. This study adds to the limited evidence base by demonstrating that gender-affirming exercise programmes are both feasible and acceptable across clinical and community settings. Findings support the broader integration of exercise into gender-affirming health care, with implications for the design of inclusive health services and physical activity policies that address the specific needs of trans youth. FAU - Austin, Felicity AU - Austin F AUID- ORCID: 0009-0004-1287-8280 AD - The University of Western Australia, Perth, Australia. AD - The Kids Research Institute Australia, Perth, Western Australia, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. FAU - Wright, Kemi AU - Wright K AUID- ORCID: 0000-0002-7146-0835 AD - The University of Western Australia, Perth, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. AD - University of New South Wales, Sydney, Australia. FAU - Lin, Ashleigh AU - Lin A AD - The University of Western Australia, Perth, Australia. AD - La Trobe University, Bundoora, Victoria, Australia. FAU - Jackson, Ben AU - Jackson B AD - The University of Western Australia, Perth, Australia. AD - The Kids Research Institute Australia, Perth, Western Australia, Australia. FAU - Moore, Julia K AU - Moore JK AD - The University of Western Australia, Perth, Australia. AD - Perth Children's Hospital, Western Australia, Australia. FAU - Saunders, Liz AU - Saunders L AD - The University of Western Australia, Perth, Australia. AD - Perth Children's Hospital, Western Australia, Australia. FAU - Laming, Bridget AU - Laming B AD - The University of Western Australia, Perth, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. FAU - Munsie, Claire AU - Munsie C AD - Curtin University, Perth, Western Australia, Australia. FAU - Kramer, Ben AU - Kramer B AD - The University of Western Australia, Perth, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. AD - South Metropolitan Health Service, Fremantle, Western Australia, Australia. FAU - Quick, Ben AU - Quick B AD - The University of Western Australia, Perth, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. FAU - Almarjawi, Ashley AU - Almarjawi A AD - Thriving in Motion, Perth, Western Australia, Australia. FAU - Simpson, Aaron AU - Simpson A AUID- ORCID: 0000-0002-0660-488X AD - The University of Western Australia, Perth, Australia. AD - The Kids Research Institute Australia, Perth, Western Australia, Australia. FAU - Furzer, Bonnie AU - Furzer B AUID- ORCID: 0000-0002-0321-6988 AD - The University of Western Australia, Perth, Australia. AD - The Kids Research Institute Australia, Perth, Western Australia, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. AD - South Metropolitan Health Service, Fremantle, Western Australia, Australia. LA - eng PT - Journal Article DEP - 20260828 PL - United States TA - Health Educ Behav JT - Health education & behavior : the official publication of the Society for Public Health Education JID - 9704962 SB - IM OTO - NOTNLM OT - adolescents OT - exercise therapy OT - gender identity OT - health OT - physical fitness OT - transgender person EDAT- 2026/08/28 23:34 MHDA- 2026/08/28 23:34 CRDT- 2026/08/28 20:32 PHST- 2026/08/28 23:34 [medline] PHST- 2026/08/28 23:34 [pubmed] PHST- 2026/08/28 20:32 [entrez] AID - 10.1177/10901981261479283 [doi] PST - aheadofprint SO - Health Educ Behav. 2026 Aug 28:10901981261479283. doi: 10.1177/10901981261479283. PMID- 42665221 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260909 IS - 1873-507X (Electronic) IS - 0031-9384 (Linking) VI - 316 DP - 2026 Nov 1 TI - Hypersensitivity to dietary fatty acids in women with restrictive anorexia nervosa: A pilot psychophysical study across chain length and saturation. PG - 115488 LID - S0031-9384(26)00271-4 [pii] LID - 10.1016/j.physbeh.2026.115488 [doi] AB - Individuals with anorexia nervosa (AN) consistently show lower fat intake and preference than healthy controls. Whether this avoidance is accompanied by altered orogustatory detection of dietary fatty acids (FAs) across chemical classes is unknown. In this pilot study, we measured psychophysical detection thresholds for lauric (C12:0, saturated), oleic (C18:1, monounsaturated), and linoleic (C18:2, polyunsaturated) acids in 50 healthy controls (76% female) and seven women with restrictive AN (rAN) using a forced choice ascending procedure (0.001-100 mM). rAN participants were reassessed at days 66 and 99 of treatment. We replicated the bimodal distribution of linoleic acid thresholds in controls (Hartigan's D= 0.102, p < .001), with a 53% taster proportion consistent with prior work. Women with rAN detected all three FAs at substantially lower concentrations than female controls (all p(FDR) 5 kg at 6-18 mo postpartum and offspring overweight/obesity at ages 7-11 y. RESULTS: Overall, 10,678 (22.1%) mothers had PPWR >5 kg, and 8287 (19.0%) offspring developed overweight/obesity. Comparing highest with lowest quintile of intake (% energy), higher total plant [RR: 0.86; 95% confidence interval (CI): 0.81, 0.91], grain (RR: 0.87; 95% CI: 0.82, 0.91), legume and nut (RR: 0.93; 95% CI: 0.88, 0.98), poultry (RR: 0.90; 95% CI: 0.85, 0.95), and fish protein (RR: 0.90; 95% CI: 0.86, 0.95) were associated with lower maternal PPWR risk, whereas higher red meat protein intake with higher risk (RR: 1.11; 95% CI: 1.05, 1.17). For offspring overweight/obesity, higher total animal (RR: 1.12; 95% CI: 1.05, 1.19), red meat (RR: 1.06; 95% CI: 1.00, 1.13), and dairy protein (RR: 1.11; 95% CI: 1.04, 1.17) were associated with higher risk, whereas poultry (RR: 0.95; 95% CI: 0.89, 0.99) and fish protein (RR: 0.93; 95% CI: 0.88, 0.99) with modestly lower risk. Replacing 1% of energy from total animal protein with plant protein, or from red meat or dairy protein with poultry, fish, or grain protein, was associated with 4%-6% lower maternal PPWR risk; corresponding substitutions with poultry or fish protein were associated with 3%-4% lower offspring risk. CONCLUSIONS: During pregnancy, substituting poultry or fish protein for red meat or dairy protein was associated with lower risks of both maternal PPWR and offspring overweight/obesity, supporting consideration of protein source in food-based dietary guidance. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Zhang, Hanyue AU - Zhang H AD - Research Unit for Diet and Health, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark; Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: hanyue.zhang@nus.edu.sg. FAU - Zheng, Miaobing AU - Zheng M AD - School of Health Sciences, Faculty of Health & Medicine, University of New South Wales, Sydney, Australia. FAU - Halldorsson, Thornorhallur I AU - Halldorsson ThornI AD - Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark; Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. FAU - Olsen, Sjurdur F AU - Olsen SF AD - Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, United States. FAU - Simpson, Stephen J AU - Simpson SJ AD - Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia. FAU - Raubenheimer, David AU - Raubenheimer D AD - Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia. FAU - Heitmann, Berit L AU - Heitmann BL AD - Research Unit for Diet and Health, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; Section for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Faculty of Health, Deakin University, Melbourne, Victoria, Australia. Electronic address: Berit.Lilienthal.Heitmann@regionh.dk. LA - eng PT - Journal Article DEP - 20260911 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Dietary Proteins) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Dietary Proteins/administration & dosage MH - *Obesity/etiology/epidemiology MH - Prospective Studies MH - Denmark/epidemiology MH - Adult MH - Child MH - *Maternal Nutritional Physiological Phenomena MH - Diet MH - Risk Factors MH - Overweight/etiology/epidemiology MH - Postpartum Period MH - Cohort Studies OTO - NOTNLM OT - Danish National Birth Cohort OT - childhood obesity OT - dietary protein OT - postpartum weight retention OT - pregnancy OT - protein source OT - substitution analysis COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/08/28 23:34 MHDA- 2026/10/05 23:29 CRDT- 2026/08/28 19:11 PHST- 2026/05/09 00:00 [received] PHST- 2026/08/21 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/10/05 23:29 [medline] PHST- 2026/08/28 23:34 [pubmed] PHST- 2026/08/28 19:11 [entrez] AID - S0002-9165(26)00317-5 [pii] AID - 10.1016/j.ajcnut.2026.101508 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Oct;124(4):101508. doi: 10.1016/j.ajcnut.2026.101508. Epub 2026 Sep 11. PMID- 42664710 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260918 IS - 1878-3252 (Electronic) IS - 0946-672X (Linking) VI - 97 DP - 2026 Oct TI - Hair iron-manganese balance in a large pediatric autism spectrum disorder cohort: Coordinated variation and an exploratory low-Fe/high-Mn subgroup. PG - 127943 LID - S0946-672X(26)00129-X [pii] LID - 10.1016/j.jtemb.2026.127943 [doi] AB - BACKGROUND: Iron (Fe) and manganese (Mn) are essential metals that share several transport and regulatory pathways. Reduced Fe status may increase Mn uptake and retention, potentially increasing susceptibility to Mn-associated neurotoxicity. Children with autism spectrum disorder (ASD) frequently have selective diets and micronutrient inadequacies, but the relationship between hair Fe and Mn has received limited attention. OBJECTIVES: This study aimed to describe age- and sex-specific distributions of hair Fe and Mn in a large pediatric ASD cohort, evaluate the association between the two elements, and explore the occurrence of a subgroup with relatively low hair Fe and relatively high hair Mn. METHODS: This retrospective cross-sectional study analyzed pre-existing hair trace-element records from a commercial laboratory for 2151 children and adolescents with an ASD diagnosis recorded in the laboratory datasets, including 1808 boys and 343 girls aged 0-18 years. Individual diagnostic records were unavailable, and the recorded diagnoses could not be independently verified. The laboratory-referred cohort was not population-representative, and no neurotypical control group was available. Hair Fe and Mn were measured by inductively coupled plasma mass spectrometry and reported in mg/100 g hair. Distributions were summarized by sex and two-year age bands. Associations between natural-log-transformed Fe and Mn were examined using correlation and linear regression adjusted for age and sex. An exploratory low-Fe/high-Mn subgroup was defined using cohort-relative thresholds of hair Fe /= 0.042 mg/100 g. RESULTS: Median hair Fe was 0.8 mg/100 g, and median hair Mn was 0.024 mg/100 g. Concentrations showed little consistent variation across age groups or between boys and girls. Log-transformed Fe and Mn were strongly positively correlated (r = 0.66). In linear regression, log Fe was positively associated with log Mn (beta = 1.22; 95% CI, 1.16-1.28; p < 0.001), and the association was unchanged after adjustment for age and sex. The model explained 44% of the variability in log Mn. The exploratory low-Fe/high-Mn subgroup comprised 62 participants (2.9%) and had a markedly lower median Fe:Mn ratio than the remaining cohort. More stringent sensitivity definitions identified progressively smaller subgroups. CONCLUSIONS: Hair Fe and Mn concentrations were strongly and positively associated in this pediatric ASD cohort, rather than showing the inverse relationship that might be expected from Fe deficiency-related Mn accumulation. A small, threshold-dependent subgroup had relatively low hair Fe, relatively high hair Mn, and a reduced Fe:Mn ratio. These hair-based patterns should not be interpreted as evidence of systemic Fe deficiency, excessive Mn exposure, or a distinct clinical phenotype. Future studies should combine standardized hair analysis with established Fe-status biomarkers, direct measures of Mn exposure, dietary and supplementation data, appropriate control groups, and validated neurodevelopmental assessments. CI - Copyright (c) 2026 Elsevier GmbH. All rights reserved. FAU - Bjorklund, Geir AU - Bjorklund G AD - Council for Nutritional and Environmental Medicine, Mo i Rana, Norway. Electronic address: bjorklund@conem.org. FAU - Watts, David AU - Watts D AD - Trace Elements, Inc, Addison, TX, USA. LA - eng PT - Journal Article DEP - 20260818 PL - Germany TA - J Trace Elem Med Biol JT - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JID - 9508274 RN - 42Z2K6ZL8P (Manganese) RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - *Hair/chemistry/metabolism MH - *Manganese/analysis/metabolism MH - *Iron/analysis/metabolism MH - Male MH - Female MH - Child MH - Child, Preschool MH - Adolescent MH - *Autism Spectrum Disorder/metabolism MH - Infant MH - Retrospective Studies MH - Cross-Sectional Studies MH - Cohort Studies MH - Infant, Newborn OTO - NOTNLM OT - Autism spectrum disorder OT - Hair OT - ICP-MS OT - Iron OT - Manganese OT - Neurodevelopment OT - Pediatric OT - Trace elements COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Geir Bjorklund has no competing financial interests or personal relationships that could have influenced the work reported in this paper. David Watts is the director of research at Trace Elements, Inc, Addison, TX, USA. EDAT- 2026/08/28 23:34 MHDA- 2026/09/18 23:36 CRDT- 2026/08/28 18:06 PHST- 2026/02/15 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/09/18 23:36 [medline] PHST- 2026/08/28 23:34 [pubmed] PHST- 2026/08/28 18:06 [entrez] AID - S0946-672X(26)00129-X [pii] AID - 10.1016/j.jtemb.2026.127943 [doi] PST - ppublish SO - J Trace Elem Med Biol. 2026 Oct;97:127943. doi: 10.1016/j.jtemb.2026.127943. Epub 2026 Aug 18. PMID- 42663907 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20261008 IS - 1867-0687 (Electronic) VI - 22 IP - 7 DP - 2026 Jul TI - Waist-to-height ratio as a practical indicator for screening pediatric metabolic dysfunction-associated steatotic liver disease in diverse populations and genetic backgrounds. PG - 805-818 LID - 10.1007/s12519-026-01084-9 [doi] AB - BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading chronic liver disease in children and adolescents; this parallels the global obesity epidemic. The contribution of genetic susceptibility to pediatric MASLD, and its interaction with anthropometric and biochemical indices used for non-invasive screening remains poorly understood. We aimed to evaluate waist-to-height ratio (WHtR) as a simple, equitable, and scalable tool for early identification of pediatric MASLD and relate this to genetic risk. METHODS: We combined school-based data from 1010 Chinese children with analyses of the Global Burden of Disease, the 1000 Genomes Project, and the US National Health and Nutrition Examination Survey (NHANES). Thirteen MASLD-related single-nucleotide polymorphisms (SNPs) were genotyped to construct a genetic risk score (GRS). We examined global epidemiological patterns, quantified inter-population allele divergence, and assessed how GRS modifies cutoffs and performance of nine anthropometric and biochemical indices. RESULTS: Genetic analysis revealed minimal frequency divergence across most ancestries (mean Fixation index < 0.05), except for the African ancestry where there was moderate divergence. Higher GRS were associated with lower cutoffs across indices. When GRS Z-score increased from -3 to 3, visceral adiposity index showed the sharpest changes (Z-score decreased from 1.5 to -1.8), while BFP (1.2 to 0.1) and WHtR (1.5 to 0.1) showed gradual change. Furthermore, incorporating GRS into the base anthropometric models yielded only marginal improvements in overall screening performance [area under the receiver operating characteristic curve (AUC) and Youden Index]. Validation in NHANES showed WHtR >/= 0.48 retained high discrimination (AUC > 0.87) across most genetic variants. CONCLUSIONS: This study suggests that WHtR is a consistent and practical tool for screening pediatric patients with MASLD across diverse populations. While genetic variation may influence optimal thresholds, WHtR >/= 0.48 appears broadly applicable, supporting its potential use as a frontline screening metric in diverse settings. CI - (c) 2026. Children's Hospital, Zhejiang University School of Medicine. FAU - Liu, Yun-Fei AU - Liu YF AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wang, You-Xin AU - Wang YX AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Li, Li AU - Li L AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China. FAU - Shi, Di AU - Shi D AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wolters, Maike AU - Wolters M AD - Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Zhang, Ping-Ping AU - Zhang PP AD - Ningbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo University, Ningbo, China. FAU - Dang, Jia-Jia AU - Dang JJ AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Cai, Shan AU - Cai S AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Huang, Tian-Yu AU - Huang TY AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wang, Ya-Qi AU - Wang YQ AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Liu, Jie-Yu AU - Liu JY AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wang, Ming-Yue AU - Wang MY AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wu, Yu-Ying AU - Wu YY AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Nur, Enkar AU - Nur E AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Lian, Wen-Jia AU - Lian WJ AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Guo, Li-Po AU - Guo LP AD - Changping Health Education Center for Primary and Secondary Schools, Beijing, China. FAU - Li, Yuan-Yuan AU - Li YY AD - Changping Health Education Center for Primary and Secondary Schools, Beijing, China. FAU - Song, Jie-Yun AU - Song JY AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Li, Jing AU - Li J AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Dong, Yan-Hui AU - Dong YH AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Cui, Yan-Chun AU - Cui YC AD - Beijing Children's Hospital, Capital Medical University, Beijing, China. FAU - Hebestreit, Antje AU - Hebestreit A AD - Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Yeo, Yee Hui AU - Yeo YH AD - Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, USA. FAU - Sawyer, Susan M AU - Sawyer SM AD - Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia. AD - Murdoch Children's Research Institute, Parkville, VIC, Australia. AD - Centre for Adolescent Health, Royal Children's Hospital, Parkville, VIC, Australia. FAU - Wang, Hui AU - Wang H AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. huiwang@bjmu.edu.cn. FAU - Song, Yi AU - Song Y AUID- ORCID: 0000-0001-6990-6781 AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. songyi@bjmu.edu.cn. LA - eng GR - 2022-1G-4251/Capital's Funds for Health Improvement and Research/ GR - 82273654/National Natural Science Foundation of China/ GR - LTGY24H260007/Zhejiang Provincial Natural Science Foundation of China/ GR - 2025KY1315/Medical Health Science and Technology Project of Zhejiang Province/ GR - 2022-B126/Cyrus Tang Foundation for Young Scholar 2022/ GR - 202406010179/China Scholarship Council/ GR - 202406010169/China Scholarship Council/ PT - Journal Article DEP - 20260828 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 SB - IM MH - Humans MH - Child MH - Female MH - *Waist-Height Ratio MH - Male MH - Genetic Predisposition to Disease MH - Adolescent MH - *Fatty Liver/diagnosis/genetics/epidemiology MH - Polymorphism, Single Nucleotide MH - China MH - Mass Screening/methods MH - Genetic Risk Score MH - Nutrition Surveys OTO - NOTNLM OT - Genetic variants OT - Metabolic dysfunction-associated steatotic liver disease OT - Pediatric OT - Screening OT - Waist-to-height ratio COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: The Beijing study and Ningbo study received approval from the Ethics Committee of Review Board of Peking University Health Science Center (Approval No. 00001052-22018) and the Ethics Committee of Ningbo First Hospital (Approval No. 2021-R168), respectively. Written informed consent was obtained from the children and their parents prior to enrollment. Analyses based on the GBD, 1000G Project, and NHANES datasets used publicly available de-identified data and therefore did not require additional ethical approval. The authors confirm that they are accountable for all aspects of the work including full data access, data integrity, and accuracy of data analysis. EDAT- 2026/08/28 18:06 MHDA- 2026/09/15 18:07 CRDT- 2026/08/28 11:27 PHST- 2025/12/23 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/03/11 00:00 [revised] PHST- 2026/09/15 18:07 [medline] PHST- 2026/08/28 18:06 [pubmed] PHST- 2026/08/28 11:27 [entrez] AID - 10.1007/s12519-026-01084-9 [pii] AID - 10.1007/s12519-026-01084-9 [doi] PST - ppublish SO - World J Pediatr. 2026 Jul;22(7):805-818. doi: 10.1007/s12519-026-01084-9. Epub 2026 Aug 28. PMID- 42663583 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260828 IS - 2219-6749 (Electronic) IS - 0258-414X (Print) IS - 0258-414X (Linking) VI - 44 IP - 2 DP - 2026 Aug 27 TI - Is the cervical bone a biological marker for bone age assessment? PG - 57-66 LID - 10.5281/zenodo.21849300 [doi] AB - Age assessment is essential in forensic practice when the chronological age of living individuals is unknown, particularly in legal, civil, migration, and asylum contexts requiring the judicial determination of age-related rights and responsibilities. This study aimed to evaluate the performance of two cervical vertebral methods in a Portuguese reference subadult population (6-23 years), ethnically homogeneous, using the analysis of the fourth cervical vertebra (C4) on lateral cephalometric radiographs. Two approaches were applied: Baccetti's qualitative morphological staging of C2-C4 and Cameriere's morphometric ratio of C4. A total of 528 lateral cephalometric radiographs, balanced by age and sex, were analysed independently by trained observers. Intra- and inter-observer reliability were evaluated using Intraclass Correlation Coefficient (ICC) and weighted Cohen's kappa (kappa). Statistical procedures included correlation analyses, multiple linear regression, Classification Trees (CT), and Receiver Operating Characteristic (ROC) curves to assess performance at legally relevant thresholds (12, 14, 16, 18 years). Baccetti's method explained 75.3% (coefficient of determination R(2)=0.753) of chronological age variability, with a mean error of approximately two years and high accuracy for thresholds of 12-16 years. Cameriere's ratio showed lower explanatory capacity (R(2)=0.568) and a mean error of 2.7 years, although its ROC curves demonstrated good discriminatory performance across all age cut-offs. The combination of both methods showed a slight increase in predictive performance (R(2)=0.784), although this combined approach was not formally evaluated as an independent model. Females reached skeletal maturity earlier, although error rates were similar between sexes. Reliability was excellent across methods. Both approaches proved applicable for forensic age assessment, offering complementary advantages: Baccetti's method provides broader morphological interpretation, whereas Cameriere's morphometric ratio offers objectivity and reproducibility. These population-specific reference data support the forensic use of cervical vertebral analysis as part of a multimodal age estimation framework. CI - Copyright(c) 2026 IOFOS This work is published and licensed by International Organization for Forensic Odonto-Stomatology. FAU - Pereira, Cristiana Palmela AU - Pereira CP AUID- ORCID: 0000-0002-9164-7189 AD - School of Dental Medicine University of Lisbon. FAU - Bonvini, Rebeca AU - Bonvini R AD - Department of Earth, Environmental and Life Sciences, University of Genoa, Italy. FAU - Santos, Rui AU - Santos R AUID- ORCID: 0000-0002-7371-363X AD - School of Technology and Management, Polytechnic University of Leiria. FAU - Vanin, Stefano AU - Vanin S AUID- ORCID: 0000-0003-1676-5916 AD - Department of Earth, Environmental and Life Sciences, University of Genoa, Italy. FAU - Cameriere, Roberto AU - Cameriere R AUID- ORCID: 0000-0002-3775-2244 AD - Department of Medicine and Health Science "Vincenzo Tiberio", University of Molise, Age Estimation Project, Campobasso, Italy. LA - eng PT - Journal Article DEP - 20260827 PL - Australia TA - J Forensic Odontostomatol JT - The Journal of forensic odonto-stomatology JID - 8501421 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - *Cervical Vertebrae/diagnostic imaging/growth & development/anatomy & histology MH - Female MH - Child MH - Adolescent MH - Cephalometry MH - Male MH - Young Adult MH - Reproducibility of Results MH - Portugal PMC - PMC13713070 OTO - NOTNLM OT - Baccetti's morphological staging system OT - Bone Age Assessment OT - Cameriere's morphometric method OT - Cephalometric OT - Cervical Vertebrae COIS- The authors report no conflicts of interest in this work. EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/12/15 CRDT- 2026/08/28 10:23 PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 10:23 [entrez] PHST- 2026/12/15 00:00 [pmc-release] AID - JFOS-44-2-57 [pii] AID - 10.5281/zenodo.21849300 [doi] PST - epublish SO - J Forensic Odontostomatol. 2026 Aug 27;44(2):57-66. doi: 10.5281/zenodo.21849300. PMID- 42663578 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261009 IS - 2219-6749 (Electronic) IS - 0258-414X (Print) IS - 0258-414X (Linking) VI - 44 IP - 2 DP - 2026 Aug 27 TI - Sexual dimorphism based on metric and non-metric parameters of human teeth in a Brazilian population. PG - 2-15 LID - 10.5281/zenodo.21848953 [doi] AB - In forensic contexts, incomplete or fragmented bones are frequently encountered due to post-mortem damage and taphonomic changes, and teeth can be considered a valid and reliable source for sex estimation, as they are among the most resistant structures of the human body. Methods based on metric and non-metric dental traits are commonly used for sex estimation. The aim of this study was to evaluate the presence of sexual dimorphism in a Brazilian population through metric and non-metric analysis of teeth. A total of 73 individuals aged between 18 and 25 years were evaluated. All analyses were conducted on the upper jaw. The metric analysis consisted of obtaining buccolingual and mesiodistal measurements of the clinical crown of the teeth. In addition to measurements for each tooth, the maxillary dental arch perimeter and intercanine distance were also considered. The non-metric analysis consisted of observing and describing traits present or absent in the teeth, using the ASUDAS. Intraobserver error was assessed using the paired t-test and the Dahlberg method. Parametric or non-parametric tests were applied according to the data distribution. The mesiodistal and buccolingual dimensions proved effective for identifying sex differences, except for teeth 12/22 (mesiodistal) and 13/23 (buccolingual). The maxillary dental arch perimeter and intercanine distance were significantly larger in males. Regarding non-metric traits, the results were less significant; only a few teeth presented traits associated with sexual dimorphism: the lingual tubercle (tooth 22), the mesial marginal ridge tubercle (tooth 26), and the hypocone cusp (teeth 17 and 27). It is concluded that the findings, although relevant, should be interpreted with caution, as their consistency still needs to be confirmed. Therefore, additional studies with larger samples from different regions of Brazil are necessary to validate these parameters and consider them reliable in anthropological and forensic contexts. CI - Copyright(c) 2026 IOFOS This work is published and licensed by International Organization for Forensic Odonto-Stomatology. FAU - Costa Rossi Junior, Wagner AU - Costa Rossi Junior W AUID- ORCID: 0000-0002-9889-414X AD - Department of Anatomy, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - Esteves, Alessandra AU - Esteves A AD - Department of Anatomy, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - Alves Nogueira, Denismar AU - Alves Nogueira D AD - Department of Statistics, Institute of Exact Sciences, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - Silva Pereira, Bruna AU - Silva Pereira B AD - School of Dentistry, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - Chiomark Malaquias, Lara Kramer AU - Chiomark Malaquias LK AD - School of Dentistry, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - de Araujo Oliveira, Clarice AU - de Araujo Oliveira C AUID- ORCID: 0009-0009-9562-1427 AD - Department of Pathology and Legal Medicine, School of Medicine of Ribeirao Preto (FMRP), University of Sao Paulo (USP), Ribeirao Preto, SP, Brazil. FAU - Alves da Silva, Ricardo Henrique AU - Alves da Silva RH AUID- ORCID: 0000-0002-1532-1670 AD - Department of Stomatology, Public Health and Forensic Odontology, Ribeirao Preto School of Dentistry (FORP), University of Sao Paulo (USP), Ribeirao Preto, SP, Brazil. LA - eng PT - Journal Article DEP - 20260827 PL - Australia TA - J Forensic Odontostomatol JT - The Journal of forensic odonto-stomatology JID - 8501421 SB - IM MH - Humans MH - Female MH - Brazil MH - Adolescent MH - Male MH - Young Adult MH - Adult MH - *Sex Characteristics MH - Forensic Dentistry MH - *Tooth/anatomy & histology MH - *Odontometry MH - Tooth Crown/anatomy & histology PMC - PMC13645323 OTO - NOTNLM OT - Dentition OT - Forensic Anthropology OT - Forensic Dentistry OT - Permanent OT - Sex Characteristics OT - Sex Determination Analysis OT - Tooth COIS- The authors report no conflicts of interest in this work. EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/12/15 CRDT- 2026/08/28 10:23 PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 10:23 [entrez] PHST- 2026/12/15 00:00 [pmc-release] AID - JFOS-44-2-02 [pii] AID - 10.5281/zenodo.21848953 [doi] PST - epublish SO - J Forensic Odontostomatol. 2026 Aug 27;44(2):2-15. doi: 10.5281/zenodo.21848953. PMID- 42663493 OWN - NLM STAT- Publisher LR - 20260828 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) DP - 2026 Aug 28 TI - Seeing is believing: The evolving role of muscle ultrasound in comprehensive nutritional care of pediatric oncology patients-A case series. LID - 10.1002/ncp.70177 [doi] AB - Traditional nutritional assessments in pediatric oncology, such as weight and body mass index, often fail to accurately capture changes in body composition, frequently masking significant muscle depletion, or secondary sarcopenia. This retrospective case series evaluates the novel clinical application of muscle ultrasound (mUS) by a pediatric oncology dietitian to help objectively guide and monitor nutrition interventions. We report our observations regarding three pediatric patients with cancer (one school-aged child and two adolescents/young adults). Serial mUS measurements of the quadriceps femoris and rectus femoris were obtained alongside standard anthropometric data. Nutritional interventions, including appetite stimulants and enteral nutrition, were tailored based on these combined assessments. In all three cases, mUS findings were discordant with total body weight trends. One patient exhibited weight gain on appetite stimulants, but mUS revealed concurrent muscle loss, prompting a transition to enteral nutrition. Conversely, another patient experienced persistent weight loss, but mUS confirmed muscle preservation and growth and led to reduced healthcare utilization. These observations suggest mUS is a feasible, non-invasive tool with potential to complement conventional anthropometric measures by detecting subclinical muscle changes that may otherwise be missed. Given the small, heterogeneous sample and retrospective design, these findings should be considered as hypothesis-generating rather than conclusive and warrant further validation in larger, prospective studies before mUS can be recommended as a standard component of nutritional assessment in pediatric oncology. CI - (c) 2026 American Society for Parenteral and Enteral Nutrition. FAU - Hawes, Corey AU - Hawes C AUID- ORCID: 0000-0002-3444-0923 AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. FAU - Radulescu, Vlad Calin AU - Radulescu VC AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. FAU - Munnikhuysen, Senna AU - Munnikhuysen S AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. LA - eng PT - Journal Article DEP - 20260828 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM OTO - NOTNLM OT - body composition OT - muscle ultrasound OT - pediatric oncology OT - secondary sarcopenia EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:49 CRDT- 2026/08/28 09:23 PHST- 2026/08/03 00:00 [revised] PHST- 2026/02/12 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/08/28 11:49 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 09:23 [entrez] AID - 10.1002/ncp.70177 [doi] PST - aheadofprint SO - Nutr Clin Pract. 2026 Aug 28. doi: 10.1002/ncp.70177. PMID- 42663129 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260903 IS - 1613-9860 (Electronic) IS - 1869-6716 (Print) IS - 1613-9860 (Linking) VI - 16 IP - 1 DP - 2026 Jan 7 TI - Documenting two decades of longitudinal changes to a community-engaged obesity prevention intervention for Native American families to facilitate scale-up. LID - 10.1093/tbm/ibag056 [doi] LID - ibag056 AB - BACKGROUND: Community-based participatory research (CBPR) interventions frequently undergo adaptation as they move from efficacy studies to dissemination; yet long-term adaptations are rarely documented in ways that support replication or scale-up. PURPOSE: To demonstrate a structured approach for retrospectively documenting longitudinal adaptations to Healthy Children, Strong Families (HCSF)-a culturally grounded, evidence-based obesity prevention intervention for Native American families-as it evolved into Turtle Island Tales. METHODS: We conducted a retrospective review of permanent records generated between 2006 and 2026 spanning three major program iterations: HCSF1, HCSF2, and Turtle Island Tales. Guided by the Framework for Reporting Adaptations and Modifications to Evidence-based Interventions (FRAME), the implementation-strategy extension FRAME-IS, and the Adaptome, adaptations were categorized as changes to intervention governance, content, structure, or strategy. Data sources included intervention materials, study protocols, quantitative and qualitative trial data, meeting minutes, and emails. RESULTS: Adaptations were layered and interdependent and were documented as preserving core functions while supporting intended implementation outcomes (e.g. acceptability, feasibility, reach, adoption, sustainability). Governance adaptations reflected shifts from more centralized, CBPR-grounded adaptation and implementation processes to greater local decision-making by community implementers. Content adaptations included greater integration of traditional knowledge and new lessons addressing sleep, emotional regulation, and family traditions. Structural adaptations involved delivery changes aligned with community systems and development of culturally resonant branding and characters. Strategy adaptations included opt-out classroom-based recruitment, embedding implementation within existing community roles, and revised training materials. CONCLUSIONS: Organizing adaptations into governance, content, structure, and strategy provides a pragmatic approach for documenting flexibility across long-term CBPR partnerships and may offer considerations for documentation of intervention adaptations in similar settings. CLINICAL TRIAL INFORMATION: The Clinical Trials Registrations #NCT01776255, NCT06298149. CI - (c) Society of Behavioral Medicine 2026. FAU - Tomayko, Emily J AU - Tomayko EJ AUID- ORCID: 0000-0002-9074-0875 AD - Department of Food Systems, Nutrition, and Kinesiology, Montana State University, Bozeman, MT, United States. AD - Center for American Indian and Rural Health Excellence, Montana State University, Bozeman, MT, United States. FAU - Estabrooks, Paul A AU - Estabrooks PA AUID- ORCID: 0000-0003-2261-9886 AD - Department of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT, United States. FAU - Warne, Teresa M AU - Warne TM AD - Center for American Indian and Rural Health Excellence, Montana State University, Bozeman, MT, United States. FAU - Merle, James L AU - Merle JL AUID- ORCID: 0000-0001-9646-2733 AD - Department of Population Health Sciences, School of Medicine, University of Utah, Salt Lake City, UT, United States. FAU - Adams, Alexandra K AU - Adams AK AD - Center for American Indian and Rural Health Excellence, Montana State University, Bozeman, MT, United States. LA - eng SI - ClinicalTrials.gov/NCT01776255 SI - ClinicalTrials.gov/NCT06298149 GR - U54 CA280812/CA/NCI NIH HHS/United States GR - 5U54CA280812/National Cancer Institute of the National Institute of Health/ PT - Journal Article PL - England TA - Transl Behav Med JT - Translational behavioral medicine JID - 101554668 SB - IM MH - Humans MH - Community-Based Participatory Research MH - Retrospective Studies MH - Child MH - Female MH - *Indians, North American MH - *Health Promotion/methods MH - *Pediatric Obesity/prevention & control MH - Longitudinal Studies MH - *Obesity/prevention & control MH - *American Indian or Alaska Native MH - Male MH - Family PMC - PMC13522849 OAB - Health promotion interventions that demonstrate effectiveness in research settings often require refinement as they are used across different communities and delivery contexts, particularly when the intervention does not fully align with local needs, cultures, or systems. This article examines how a family-based wellness program developed in partnership with multiple Native American communities changed over two decades as it moved from research trials into broader community use. Originally developed as Healthy Children, Strong Families and later renamed Turtle Island Tales, the program underwent adaptations to strengthen cultural relevance, improve feasibility, and support sustained use. Over time, local community partners adjusted how the program was delivered, how families were invited to participate, and how materials reflected culture and community values. These changes included integrating cultural teachings and storytelling, shifting from mailed home delivery to school- and community-based delivery, and aligning implementation with existing community roles and systems. Throughout this process, the program's focus on family health promotion was intentionally maintained. By documenting a way to categorize adaptations across longer-term stages of program development, this article provides guidance for educators, community organizations, and researchers on how programs can be adapted across settings while maintaining the elements necessary to achieve intended outcomes. OABL- eng OTO - NOTNLM OT - American Indian/Alaska Native OT - health behavior OT - health promotion OT - implementation science OT - pediatric obesity OT - program evaluation COIS- All authors declare that they have no conflicts of interest. EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/08/28 CRDT- 2026/08/28 06:43 PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 06:43 [entrez] PHST- 2026/08/28 00:00 [pmc-release] AID - 8772273 [pii] AID - ibag056 [pii] AID - 10.1093/tbm/ibag056 [doi] PST - ppublish SO - Transl Behav Med. 2026 Jan 7;16(1):ibag056. doi: 10.1093/tbm/ibag056. PMID- 42662625 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260829 IS - 1937-8688 (Electronic) VI - 53 DP - 2026 TI - Association of oxidative stress, inflammation, and ADIPOQ gene expression in young adults at risk of non-alcoholic fatty liver disease and cardiovascular disease. PG - 175 LID - 10.11604/pamj.2026.53.175.47681 [doi] LID - 175 AB - INTRODUCTION: non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) are increasingly seen in young adults due to obesity, sedentary lifestyle, and poor diet. Oxidative stress and chronic inflammation are key contributors to their development, promoting liver damage, endothelial dysfunction, and atherosclerosis. Adiponectin, encoded by the ADIPOQ gene, has protective metabolic effects, and its reduction, often influenced by genetic factors, is linked to increased disease risk. This study evaluates the relationship between oxidative stress (MDA), inflammation (IL-6), and ADIPOQ gene expression in young adults to identify early biomarkers. METHODS: this case-control study (2022 December-2024 December) included 300 participants aged 18-45 years with clinically established non-alcoholic fatty liver and/or cardiovascular risk disease, who were categorized as the case group. The remaining 150 healthy individuals served as the control group. MDA and IL-6 levels were measured using ELISA, while ADIPOQ expression was analyzed via reverse transcription polymerase chain reaction (RT-PCR). Data were analyzed using t-tests, receiver operating characteristic (ROC) analysis, and quantile regression in Stata 17.0, with significance set at p<0.05. RESULTS: cases showed elevated MDA and IL-6 levels and reduced ADIPOQ expression compared to controls. ROC analysis identified MDA as the strongest biomarker (AUC = 0.9605). IL-6 showed diagnostic potential but lost significance after adjustment for sociodemographic variables. MDA and IL-6 levels negatively correlated with ADIPOQ expression. CONCLUSION: oxidative stress and inflammation are associated with reduced ADIPOQ expression in young adults at risk of NAFLD and CVD. While ADIPOQ alone may have limited predictive power, early identification of oxidative and inflammatory markers could aid in timely intervention. CI - Copyright: Rachana Raveendran et al. FAU - Raveendran, Rachana AU - Raveendran R AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Josephine, Anthony AU - Josephine A AD - Department of Research, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Sureka, Varalakshmi AU - Sureka V AD - Department of Research, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Kalaiselvi, Periandavan AU - Kalaiselvi P AD - Department of Medical Biochemistry, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Tamil Nadu, India. FAU - Varma, Poornima Raja Raja AU - Varma PRR AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Kandy, Lasitha Neroth AU - Kandy LN AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Nair, Renjith Kariyil Radhakrishnan AU - Nair RKR AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Kottola, Manjusha AU - Kottola M AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Mohanan, Midhun Thazhissery AU - Mohanan MT AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Thoduvayil, Swathi AU - Thoduvayil S AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Abdulla, Thahira AU - Abdulla T AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Kottiyath, Pinchulatha AU - Kottiyath P AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Divakaran, Dinesh Roy AU - Divakaran DR AD - Genetika, Centre for Advanced Genetic Studies, Thiruvananthapuram, Kerala, India. LA - eng PT - Journal Article DEP - 20260427 PL - Uganda TA - Pan Afr Med J JT - The Pan African medical journal JID - 101517926 RN - 0 (Adiponectin) RN - 0 (ADIPOQ protein, human) RN - 0 (Biomarkers) RN - 0 (Interleukin-6) RN - 4Y8F71G49Q (Malondialdehyde) RN - 0 (IL6 protein, human) SB - IM MH - Humans MH - *Adiponectin/genetics MH - *Oxidative Stress/physiology MH - *Non-alcoholic Fatty Liver Disease/genetics/epidemiology MH - Female MH - Male MH - Adult MH - Case-Control Studies MH - Young Adult MH - *Inflammation/epidemiology MH - *Cardiovascular Diseases/epidemiology/genetics MH - Adolescent MH - Biomarkers/metabolism MH - Interleukin-6/metabolism/blood MH - Middle Aged MH - Gene Expression MH - Enzyme-Linked Immunosorbent Assay MH - Malondialdehyde/metabolism MH - ROC Curve PMC - PMC13521425 OTO - NOTNLM OT - ADIPOQ gene expression OT - cardiovascular disease OT - inflammatory markers OT - non-alcoholic fatty liver disease OT - oxidative stress COIS- The authors declare no competing interests. EDAT- 2026/08/28 11:50 MHDA- 2026/08/28 11:51 PMCR- 2026/04/27 CRDT- 2026/08/28 06:13 PHST- 2025/04/21 00:00 [received] PHST- 2025/06/03 00:00 [accepted] PHST- 2026/08/28 11:51 [medline] PHST- 2026/08/28 11:50 [pubmed] PHST- 2026/08/28 06:13 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - PAMJ-53-175 [pii] AID - 10.11604/pamj.2026.53.175.47681 [doi] PST - epublish SO - Pan Afr Med J. 2026 Apr 27;53:175. doi: 10.11604/pamj.2026.53.175.47681. eCollection 2026. PMID- 42662191 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260828 LR - 20260829 IS - 2633-0040 (Electronic) IS - 2633-0040 (Linking) VI - 7 DP - 2026 Jan-Dec TI - Interim analysis of an international multi-site prospective natural history study evaluating the clinical presentation and progression of Leigh syndrome spectrum disorders. PG - 26330040261476231 LID - 10.1177/26330040261476231 [doi] LID - 26330040261476231 AB - BACKGROUND: Leigh Syndrome Spectrum (LSS) is the most common pediatric mitochondrial disease syndromic presentation. However, its natural history has not been well-characterized, particularly across diverse populations. OBJECTIVES: Information obtained through robust, prospective natural history studies (NHSs) in LSS will be foundational to accurately counsel newly diagnosed families, develop effective therapeutics, and identify outcome measures for future clinical trials. DESIGN: We describe an ongoing multi-site, international, patient advocacy group funded, observational NHS in LSS. We employed a multi-site international federated design with local regulatory review coupled with central regulatory and coordinator support. To date, NHS outcome measures have been collected on LSS participants across 5 sites every 3 to 6 months for up to 3.8 years. METHODS: Objective and subjective outcome measures were carefully selected by the international LSS outcome measure working group. Study data across sites were anonymized and combined for cleaning and analysis at the Data Coordinating Center (Children's Hospital of Philadelphia). Descriptive statistics of the study cohort and inter-measure correlations were analyzed across NHS assessments. RESULTS: Preliminary analysis of the first 74 participants was completed to characterize demographics, symptomatology, and clinical history. The average age at enrollment was 10.7 years, ranging from 0 to 50 years. The most common gene disorders were MT-ATP6 (22%, n=16), MT-ND5 (8%, n=6) and SURF1 (8%, n=6). No statistically significant between-group differences were detected by sex or genetic etiology. High inter-measure correlation between all the outcome measures and "gold standard" outcomes provides justification for future use of these assessments in both NHSs and clinical trials. CONCLUSION: We have demonstrated the feasibility of prospectively collecting robust international-site LSS NHS data through multi-site collaboration. These LSS community data will be critical for informing therapeutic development, outcome measure selection and clinical trial design, and providing baseline comparator evidence for development of future therapeutic interventions. CI - (c) The Author(s) 2026. FAU - MacMullen, Laura E AU - MacMullen LE AUID- ORCID: 0000-0003-2458-6889 AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Stanley, Katelynn D AU - Stanley KD AUID- ORCID: 0009-0008-0042-5435 AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Christodoulou, John AU - Christodoulou J AD - Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia. RINGGOLD: 34361 AD - Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia. FAU - Cohen, Bruce H AU - Cohen BH AUID- ORCID: 0000-0003-2253-8955 AD - Rebecca D. Considine Research Institute, Akron Children's Hospital, Akron, OH, USA. RINGGOLD: 1079 AD - Department of Pediatrics, Akron Children's Hospital, Akron, OH, USA. RINGGOLD: 1079 FAU - Demczko, Matthew AU - Demczko M AUID- ORCID: 0000-0003-0232-9611 AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Goldstein, Amy C AU - Goldstein AC AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Haas, Richard AU - Haas R AD - Department of Pediatrics, University of California, San Diego, CA, USA. AD - The Department of Neurosciences, University of California San Diego. RINGGOLD: 8784 AD - Rady Children's Hospital, UC San Diego School of Medicine, La Jolla, CA, USA. FAU - Koenig, Mary Kay AU - Koenig MK AD - Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at UTHealth Houston, Houston, TX, USA. FAU - Poblete, Maria AU - Poblete M AD - Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at UTHealth Houston, Houston, TX, USA. FAU - Rice, Alyssa AU - Rice A AD - Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at UTHealth Houston, Houston, TX, USA. FAU - Rossman, Ian AU - Rossman I AD - Rebecca D. Considine Research Institute, Akron Children's Hospital, Akron, OH, USA. RINGGOLD: 1079 FAU - Ruiz, Carolina AU - Ruiz C AD - The Department of Neurosciences, University of California San Diego. RINGGOLD: 8784 AD - Rady Children's Hospital, UC San Diego School of Medicine, La Jolla, CA, USA. FAU - Russo, S Nicholas AU - Russo SN AUID- ORCID: 0000-0001-5045-9301 AD - Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at UTHealth Houston, Houston, TX, USA. FAU - Thorburn, David R AU - Thorburn DR AD - Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia. RINGGOLD: 34361 AD - Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia. FAU - Uebergang, Eloise AU - Uebergang E AUID- ORCID: 0000-0003-0305-7822 AD - Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia. RINGGOLD: 34361 FAU - Yang, Jennifer H AU - Yang JH AUID- ORCID: 0000-0001-5438-7210 AD - The Department of Neurosciences, University of California San Diego. RINGGOLD: 8784 AD - Rady Children's Hospital, UC San Diego School of Medicine, La Jolla, CA, USA. FAU - Zolkipli-Cunningham, Zarazuela AU - Zolkipli-Cunningham Z AUID- ORCID: 0000-0002-0743-8879 AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Falk, Marni J AU - Falk MJ AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. CN - Leigh Syndrome Roadmap Project Natural History Study Consortium LA - eng PT - Journal Article DEP - 20260826 PL - England TA - Ther Adv Rare Dis JT - Therapeutic advances in rare disease JID - 9918557474706676 PMC - PMC13519198 OAB - WHY WAS THE STUDY DONE? Leigh Syndrome Spectrum (LSS) Disorders are the most common type of pediatric mitochondrial disease. Potentially affecting both children and adults, LSS manifest with stroke-like brain lesions, muscle dysfunction, exercise intolerance, impaired cognitive development or function, and sometimes early death. Through controlled studies in diverse populations over long periods of time, researchers can gather information necessary to better counsel patients and families about disease symptoms and outcomes and design improved clinical trials. WHAT DID THE RESEARCHERS DO? Patient advocacy groups and academic medicine centers from around the world collaborated to design a natural history study that follows patients with LSS at multiple sites for up to five years. We gathered experts to determine a comprehensive set of administered tests and patient/family surveys that would most accurately capture the symptoms and downstream effects of living with LSS. We compiled preliminary data from the first five data collection sites to describe the characteristics of the participants. WHAT DID THE RESEARCHERS FIND? Data from the first 74 participants was summarized to understand the characteristics of the group and the most common symptoms. No symptomatic differences were found by patient sex or genetic subtype. High inter-measure correlation between all of the studied outcome measures with "gold standard" outcome measures validated that the studied assessments test what they were intended to evaluate and that they may ultimately be useful assessments in future observational and treatment studies in LSS patients. WHAT DO THE FINDINGS MEAN? This work demonstrates the feasibility of collecting high quality, useful data across many different medical sites across the world and using that data to better understand LSS. These findings may help clinicians most accurately counsel and care, design better clinical trials, and serve as supporting data during the drug development and review process of future candidate therapies. OABL- eng OTO - NOTNLM OT - Leigh syndrome spectrum OT - mitochondrial disease OT - natural history OT - neurodegenerative disease COIS- The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: JC and DRT serve on the board of directors and are members of its Scientific and Medical Advisory Panel for the Mito Foundation, which funds the Australian node of the NHS, and is on the SMAP of the Childhood Dementia Initiative. Unrelated to this work, JY receives research funding from the National Institute of Health and Pediatric Epilepsy Research Foundation. She has received speaker fees from UCB. ACG serves on the advisory board of UCB. ZZ serves on the Scientific and Medical Advisory Board of the United Mitochondrial Disease Foundation. MJF serves on the UMDF Scientific and Medical Advisory Board, and is an invited editorial member of this journal (although has not reviewed any articles for this journal to date). EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/08/26 CRDT- 2026/08/28 05:46 PHST- 2025/11/19 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 05:46 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - 10.1177_26330040261476231 [pii] AID - 10.1177/26330040261476231 [doi] PST - epublish SO - Ther Adv Rare Dis. 2026 Aug 26;7:26330040261476231. doi: 10.1177/26330040261476231. eCollection 2026 Jan-Dec. PMID- 42661870 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260903 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Measurement tools for sedentary behavior in the Arabic-speaking countries in MENA region: a systematic review of validated instruments from the BRIDGE project. PG - 1815050 LID - 10.3389/fpubh.2026.1815050 [doi] LID - 1815050 AB - BACKGROUND: Sedentary behavior is an independent risk factor for adverse health outcomes. Screen time represents a specific domain of sedentary behavior and is often used as a proxy. Accurate measurement of these behaviors is essential for surveillance, research, and intervention. However, the availability, characteristics, and psychometric quality of validated instruments used to assess these behaviors in Arabic-speaking countries in the Middle East and North Africa (MENA) region have not been well documented. This systematic review aimed to identify, describe, and critically appraise the instruments used to assess sedentary behavior and/or screen time in this region. METHODS: This systematic review was conducted according to the PRISMA guidelines. Major electronic databases were searched to identify studies that reported the development, cross-cultural adaptation, or validation of instruments measuring sedentary behavior or screen time in Arabic-speaking MENA countries. Studies assessing at least one measurement property were eligible. Data on study characteristics, instruments, and psychometric properties were extracted. The methodological quality and measurement properties were evaluated using the COSMIN framework. RESULTS: Ten studies conducted in five MENA countries (Jordan, United Arab Emirates, Saudi Arabia, Morocco, and Syria) were included. Most studies relied on self-reported questionnaires originally designed to assess physical activity, with sedentary behavior measured as a secondary dimension. The most frequently evaluated instruments were the International Physical Activity Questionnaire (IPAQ), Global Physical Activity Questionnaire (GPAQ), and Global School-based Student Health Survey (GSHS). Only one instrument, the Sedentary Behavior Questionnaire (SBQ), was specifically designed to measure sedentary behavior and was validated in two countries among adults and university students. Overall, the psychometric properties were often insufficient or inconsistent, particularly for criterion validity. Evidence among children and adolescents is limited and mainly focuses on screen time, showing weak agreement with objective measures. CONCLUSION: The measurement of sedentary behavior in Arabic-speaking MENA countries relies largely on non-specific instruments with limited psychometric evidence. There is a clear need for the development and rigorous validation of culturally adapted, sedentary behavior-specific tools across age groups to support research, surveillance, and public health policies in the region. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261283730, Identifier: CRD420261283730. CI - Copyright (c) 2026 Bartal, Bahra, Hussien, Aly, Abdelkarim and El Rhazi. FAU - Bartal, Fatima Zahrae AU - Bartal FZ AD - Laboratory of Epidemiology, Clinical Research, and Community Health, Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohamed Ben Abdallah University, Fez, Morocco. FAU - Bahra, Nassiba AU - Bahra N AD - Laboratory of Epidemiology, Clinical Research, and Community Health, Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohamed Ben Abdallah University, Fez, Morocco. FAU - Hussien, Fatma AU - Hussien F AD - Faculty of Sport Sciences, Capital University, Giza, Egypt. FAU - Aly, Mohamed AU - Aly M AD - Faculty of Sport Sciences, Assiut University, Assiut, Egypt. AD - Department of Sports Management, School of Business, ESLSCA University, Cairo, Egypt. FAU - Abdelkarim, Osama AU - Abdelkarim O AD - Faculty of Sport Sciences, Assiut University, Assiut, Egypt. AD - Department of Sports Management, School of Business, ESLSCA University, Cairo, Egypt. AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - El Rhazi, Karima AU - El Rhazi K AD - Laboratory of Epidemiology, Clinical Research, and Community Health, Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohamed Ben Abdallah University, Fez, Morocco. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260813 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Africa, Northern MH - Middle East MH - Middle Eastern People MH - Psychometrics MH - Reproducibility of Results MH - *Screen Time MH - *Sedentary Behavior MH - Surveys and Questionnaires/standards MH - North African People PMC - PMC13518537 OTO - NOTNLM OT - Arabic-speaking countries OT - COSMIN OT - MENA region OT - measurement instruments OT - psychometric properties OT - sedentary behavior COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/08/13 CRDT- 2026/08/28 05:23 PHST- 2026/02/21 00:00 [received] PHST- 2026/06/25 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 05:23 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1815050 [doi] PST - epublish SO - Front Public Health. 2026 Aug 13;14:1815050. doi: 10.3389/fpubh.2026.1815050. eCollection 2026. PMID- 42661784 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260828 LR - 20260829 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Feasibility, uptake, and exploratory outcomes of an individualized exercise program in pediatric oncology: a prospective single-center pilot study. PG - 1914065 LID - 10.3389/fped.2026.1914065 [doi] LID - 1914065 AB - INTRODUCTION: Exercise interventions may help mitigate treatment-related physical impairment in pediatric oncology, but implementation in routine care remains challenging, particularly during active treatment and in heterogeneous patient cohorts. PATIENTS: This prospective single-center pilot study evaluated an individualized exercise program for children and adolescents aged 4-17 years undergoing cancer treatment during the COVID-19 pandemic. METHOD: The program combined supervised in-hospital exercise, personalized home-based training, and an optional video-based SMART-Sport component introduced from month 3. The primary focus was feasibility, uptake, safety, and acceptability. Motor performance, six-minute walk distance, health-related quality of life (HRQoL), and neuropsychological functioning were assessed at baseline and six months as secondary exploratory outcomes. RESULTS: Twenty participants were enrolled; 15 completed at least one six-month follow-up assessment. Overall, 348 of 583 scheduled in-hospital exercise opportunities were attended, corresponding to a scheduled-session attendance of 59.7% using a conservative denominator. No serious program-related adverse event occurred. Movement diaries were available for 15 participants and documented 361 home-training sessions, of which 262 (72.6%) occurred during the first three months. Four participants documented use of SMART-Sport, completing 14 sessions. Exploratory complete-case analyses showed nominal within-participant improvements in hand-eye coordination, reaction time, six-minute walk distance, and selected HRQoL domains. Neuropsychological findings were inconclusive. DISCUSSION: The findings support the feasibility and safety of supervised individualized in-hospital exercise under the conditions of a specialized pediatric oncology center with a dedicated sports therapist. Feasibility was component-specific: home-training documentation decreased over time, and uptake of the optional video-based component was limited. CONCLUSION: This pilot study provides preliminary implementation data supporting further development of individualized exercise programs in pediatric oncology. Exploratory outcome findings should be interpreted as hypothesis-generating and require confirmation in larger controlled studies. CI - (c) 2026 Schuster, Loos, Traunwieser, Fruhwald and Kuhlen. FAU - Schuster, Christina AU - Schuster C AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Loos, Elena AU - Loos E AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Traunwieser, Thomas AU - Traunwieser T AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Fruhwald, Michael C AU - Fruhwald MC AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Kuhlen, Michaela AU - Kuhlen M AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. LA - eng PT - Journal Article DEP - 20260813 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13518581 OTO - NOTNLM OT - exercise therapy OT - feasibility OT - pediatric oncology OT - physical activity OT - quality of life OT - supportive care COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/28 11:50 MHDA- 2026/08/28 11:51 PMCR- 2026/08/13 CRDT- 2026/08/28 05:16 PHST- 2026/06/19 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/08/28 11:51 [medline] PHST- 2026/08/28 11:50 [pubmed] PHST- 2026/08/28 05:16 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.3389/fped.2026.1914065 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 13;14:1914065. doi: 10.3389/fped.2026.1914065. eCollection 2026. PMID- 42661386 OWN - NLM STAT- Publisher LR - 20260828 IS - 1467-789X (Electronic) IS - 1467-7881 (Linking) DP - 2026 Aug 27 TI - Harnessing Systems Science to Strengthen Community-Based Childhood Obesity Prevention: An Overview of the Literature. PG - e70218 LID - 10.1111/obr.70218 [doi] AB - INTRODUCTION: Addressing the obesity epidemic requires understanding the complex and multilevel dynamics that shape it. Systems science can help researchers and practitioners move beyond linear causal logic. This overview identifies empirical studies using explicit systems science methods or broader systems-informed approaches to design, implement, or evaluate community-based childhood obesity prevention efforts. We report how systems methods have been applied, their contributions to tackling obesity, challenges, and opportunities. METHODS: We searched Web of Science for English-language publications reporting empirical applications of systems thinking, systems science methods, or systems-informed ecological and participatory approaches in community-level childhood obesity prevention. Three reviewers screened 273 records, assessed full texts, and extracted data. RESULTS: Ninety-eight articles met inclusion criteria. Systems approaches were used most often during intervention design (n = 50; 51.0%), followed by implementation (n = 23; 23.5%) and evaluation (n = 14; 14.3%), with some spanning multiple stages (n = 11; 11.2%). Participatory methods such as group model building deepened understanding of structural and relational drivers, and supported context-specific adaptation and cross-sector coordination. The use of systems approaches for evaluation was limited, though emerging methods (e.g., ripple-effect mapping, longitudinal network analysis, and agent-based modeling) signal growing opportunity. Barriers included limited infrastructure for cross-sector collaboration, funding misalignment, and a lack of shared or validated metrics. CONCLUSION: Systems science has strengthened the field's ability to visualize complexity and align stakeholders in interventions' design and implementation. Its application in evaluation and scale-up remains limited. Sustained investment in participatory capacity, longitudinal infrastructure, and systems-informed implementation is needed to strengthen community-based childhood obesity prevention. CI - (c) 2026 The Author(s). Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Moore, Travis R AU - Moore TR AUID- ORCID: 0000-0002-7874-0813 AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. AD - Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Chang Chusan, Yuilyn A AU - Chang Chusan YA AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. FAU - Calancie, Larissa AU - Calancie L AUID- ORCID: 0000-0002-8943-5590 AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. FAU - Tamvakologos, Panos I AU - Tamvakologos PI AUID- ORCID: 0009-0000-3450-7713 AD - School of Medicine, St. Georges University, University Centre, St. George's, Grenada. AD - Department of Pediatrics, Maimonides Children's Hospital, Brooklyn, New York, USA. FAU - Economos, Christina D AU - Economos CD AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Review DEP - 20260827 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 SB - IM OTO - NOTNLM OT - childhood OT - community OT - obesity OT - primary care OT - systems science EDAT- 2026/08/28 11:46 MHDA- 2026/08/28 11:46 CRDT- 2026/08/28 01:43 PHST- 2026/07/20 00:00 [revised] PHST- 2026/02/10 00:00 [received] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/08/28 11:46 [pubmed] PHST- 2026/08/28 01:43 [entrez] AID - 10.1111/obr.70218 [doi] PST - aheadofprint SO - Obes Rev. 2026 Aug 27:e70218. doi: 10.1111/obr.70218. PMID- 42661054 OWN - NLM STAT- Publisher LR - 20260827 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Aug 27 TI - Sex-specific associations between pubertal development and MASLD in children: evidence from the PROC study. LID - 10.1038/s41390-026-05398-2 [doi] AB - BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in children. This study aimed to determine the sex-specific association between pubertal development and risk of MASLD in children. METHODS: This longitudinal study included 1544 children aged 10-13 years from two follow-ups of a Chinese pediatric cohort (the PROC study) in Beijing. Pubertal development was assessed using Tanner staging. We employed Bayesian logistic regression to examine the cross-sectional association between pubertal development and MASLD, and employed Bayesian mixed-effects models to verify its longitudinal association. External validation was performed using National Health and Nutrition Examination Survey (NHANES) data, where puberty was defined by total testosterone in boys and estradiol in girls. RESULTS: The overall prevalence of MASLD declined with advancing pubertal stages. In boys, compared with early puberty, mid-puberty (aOR = 0.34, 95% highest density interval (HDI): 0.11-0.68) and late puberty (aOR = 0.22, 95% HDI: 0.03-0.59) showed significantly lower MASLD risk. No significant association was observed among girls. NHANES validation confirmed this protective association in boys at late puberty (aOR = 0.25, 95% HDI: 0.01-0.95), but not in girls. CONCLUSIONS: Mid-to-late puberty may significantly decrease the risk of MASLD in boys, whereas no clear association was observed in girls. IMPACT: This study reveals a sex-specific protective effect of puberty on MASLD risk in children, with advancing puberty associated with significantly lower odds of MASLD in boys, but not in girls. It adds longitudinal evidence on the puberty-MASLD association by assessing puberty via Tanner staging and conducting sex-specific analyses. The impact is to support tailoring prevention resources and health messages for MASLD by sex during puberty. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - He, Huiming AU - He H AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Guan, Mengying AU - Guan M AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Abudumijiti, Tuerxunayi AU - Abudumijiti T AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Li, Miao AU - Li M AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Zou, Yuchen AU - Zou Y AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Vermund, Sten H AU - Vermund SH AD - College of Public Health, University of South Florida, Tampa, FL, USA. FAU - Huang, Dayong AU - Huang D AD - Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. hdayong@yahoo.com. FAU - Hu, Yifei AU - Hu Y AUID- ORCID: 0000-0002-4611-2206 AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. huyifei@yahoo.com. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. huyifei@yahoo.com. LA - eng PT - Journal Article DEP - 20260827 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Ethics statement: Studies involving human participants were reviewed and approved by the Institutional Review Board of Capital Medical University (No.2018SY82). Written informed consent was obtained from participants' legal guardians prior to participation. For external validation, data from the NHANES were used. The NHANES is a publicly available, de-identified dataset, and all procedures were approved by the National Center for Health Statistics Ethics Review Board. Written informed consent was obtained from all participants in the NHANES. Therefore, no additional ethical approval was required for the use of the secondary data. Consent statement: Written informed consent to participate in this study was obtained from the participants' legal guardians. EDAT- 2026/08/28 11:46 MHDA- 2026/08/28 11:46 CRDT- 2026/08/27 23:55 PHST- 2026/04/06 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/06/18 00:00 [revised] PHST- 2026/08/28 11:46 [medline] PHST- 2026/08/28 11:46 [pubmed] PHST- 2026/08/27 23:55 [entrez] AID - 10.1038/s41390-026-05398-2 [pii] AID - 10.1038/s41390-026-05398-2 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Aug 27. doi: 10.1038/s41390-026-05398-2. PMID- 42660934 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260830 IS - 2396-8370 (Electronic) IS - 2396-8370 (Linking) VI - 10 IP - 1 DP - 2026 Aug 7 TI - A machine learning-derived dietary pattern for aging. LID - 10.1038/s41538-026-01048-3 [doi] LID - 264 AB - Diet is a modifiable determinant of aging. We develop and validate the Machine-learning YouTHful (MYTH) Diet, a dietary pattern associated with reduced aging-related mortality. Using data from 191,689 participants in the UK Biobank, we conducted a food-wide association analysis and identified 18 food groups significantly associated with aging-related mortality. A Light Gradient Boosting Machine (LightGBM) model was used to rank food importance, leading to the construction of a 10-component MYTH Diet score (range: 0-10). Higher MYTH scores were consistently associated with reduced aging-related mortality in both internal (Quartile 4 vs. 1: hazard ratio [HR] = 0.79; 95% CI: 0.75-0.84) and external (Q4 vs. Q1: HR = 0.68; 95% CI: 0.58-0.80) validation cohorts. Multi-omics analyses revealed that the diet's protective effects were partly mediated through proteomic, metabolic, and inflammatory pathways, with mediators including TNFRSF4, the proportion of polyunsaturated fatty acids (PUFA%), and lipid-related metabolites such as medium very-low-density lipoprotein phospholipids (M-VLDL-PL). Higher MYTH scores were also linked to slower biological aging in the lungs, liver, pancreas, as well as lower risks for 15 aging-related diseases. These findings suggest that the MYTH Diet may offer a biologically informed, scalable framework for developing personalized nutrition strategies aimed at supporting healthy aging and longevity. CI - (c) 2026. The Author(s). FAU - Miao, Yating AU - Miao Y AD - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, Ministry of Education, China Medical University; Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, China. FAU - Li, Zhirong AU - Li Z AD - Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, China. FAU - Zhang, Xinyao AU - Zhang X AD - Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, China. food@jlu.edu.cn. FAU - Liu, Zuyun AU - Liu Z AD - Department of Big Data in Health Science School of Public Health, Center for Clinical Big Data and Analytics Second Affiliated Hospital, Zhejiang Key Laboratory of Intelligent Preventive Medicine, Zhejiang University School of Medicine, Hangzhou, China. Zuyun.liu@outlook.com. FAU - Ma, Yanan AU - Ma Y AD - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, Ministry of Education, China Medical University; Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, China. ynma@cmu.edu.cn. AD - Health Sciences Institute, China Medical University; Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, China. ynma@cmu.edu.cn. LA - eng GR - 72074221/National Natural Science Foundational of China/ GR - 2026-MS-190/Natural Science Foundation of Liaoning Province/ PT - Journal Article DEP - 20260807 PL - England TA - NPJ Sci Food JT - NPJ science of food JID - 101739627 PMC - PMC13522610 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/08/28 11:46 MHDA- 2026/08/28 11:47 PMCR- 2026/08/07 CRDT- 2026/08/27 23:21 PHST- 2026/04/13 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/28 11:47 [medline] PHST- 2026/08/28 11:46 [pubmed] PHST- 2026/08/27 23:21 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 10.1038/s41538-026-01048-3 [pii] AID - 1048 [pii] AID - 10.1038/s41538-026-01048-3 [doi] PST - epublish SO - NPJ Sci Food. 2026 Aug 7;10(1):264. doi: 10.1038/s41538-026-01048-3. PMID- 42660645 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260911 IS - 1573-2665 (Electronic) IS - 0141-8955 (Print) IS - 0141-8955 (Linking) VI - 49 IP - 5 DP - 2026 Sep TI - Treating a Disorder Caused by an Overactive Enzyme: BCKD-Kinase Deficiency. PG - e70242 LID - 10.1002/jimd.70242 [doi] LID - e70242 AB - Branched-chain ketoacid dehydrogenase kinase (BCKDK) deficiency is a rare autosomal recessive disorder. Loss of this kinase leaves the branched-chain alpha-ketoacid dehydrogenase complex constitutively active, leading to depletion of branched-chain amino acids (BCAAs) rather than their accumulation. To date, 31 patients from 20 families have been reported. In the largest systematic series, global developmental delay and intellectual disability are universal, autism spectrum disorder occurs in 71%, epilepsy in 43%, and progressive postnatal microcephaly. Mean age at diagnosis is close to 6 years, partly because the clinical picture resembles many forms of idiopathic neurodevelopmental disability. Treatment with a high-protein diet (>/= 2 g/kg/day) and BCAA supplementation (100-250 mg/kg/day) can normalize plasma BCAA levels and appears to stabilize motor function and head circumference. In the limited data available, three patients who started treatment before age 2 did not develop autism, and the earliest-treated patient (8 months) was developing normally at 3 years of follow-up. However, current therapy has clear limitations. Tracer studies in Bckdk knockout mice show reduced incorporation of BCAA-derived nitrogen into brain glutamate even with dietary intervention, pointing to a gap between peripheral biochemical correction and what the brain actually receives. Emerging strategies include partial pharmacological suppression of BCKDH activity, stabilization of residual mutant BCKDK protein, and gene therapy. Newborn screening, feasible with existing technology, deserves consideration given the contrast in outcomes between early and late treatment. This review examines what current treatment achieves, where it falls short, and what additional strategies may be needed. CI - (c) 2026 SSIEM. FAU - Ribeiro-Constante, Juliana AU - Ribeiro-Constante J AUID- ORCID: 0009-0001-5912-0555 AD - Neurometabolic Unit and Synaptic Metabolism Lab, Department of Neurology, Hospital Sant Joan de Deu-IRSJD and CIBERER, Barcelona, Spain. AD - Medicina i Recerca Translacional, Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. AD - European Reference Network for Hereditary Metabolic Diseases (MetabERN). FAU - Tangeraas, Trine AU - Tangeraas T AD - European Reference Network for Hereditary Metabolic Diseases (MetabERN). AD - Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Garcia-Cazorla, Angeles AU - Garcia-Cazorla A AUID- ORCID: 0000-0001-9853-688X AD - Neurometabolic Unit and Synaptic Metabolism Lab, Department of Neurology, Hospital Sant Joan de Deu-IRSJD and CIBERER, Barcelona, Spain. AD - Medicina i Recerca Translacional, Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. AD - European Reference Network for Hereditary Metabolic Diseases (MetabERN). LA - eng GR - Fondo Europeo de Desarrollo Regional (FEDER)/ GR - PI24/00469/Instituto de Salud Carlos III (ISCIII)/ PT - Journal Article PT - Review PL - United States TA - J Inherit Metab Dis JT - Journal of inherited metabolic disease JID - 7910918 RN - EC 2.7.11.4 ((3-methyl-2-oxobutanoate dehydrogenase (lipoamide)) kinase) RN - 0 (Amino Acids, Branched-Chain) RN - EC 2.7.- (Protein Kinases) SB - IM MH - Humans MH - *Amino Acids, Branched-Chain/therapeutic use/metabolism MH - Animals MH - Diet, High-Protein MH - Mice MH - Developmental Disabilities MH - Autism Spectrum Disorder MH - Child MH - Protein Kinases PMC - PMC13521751 OTO - NOTNLM OT - BCKDK deficiency OT - autism spectrum disorder OT - branched-chain amino acids OT - metabolic encephalopathy OT - newborn screening OT - treatable neurodevelopmental disorder COIS- A.G.C. has received honoraria for research support and lectures from PTC Therapeutics, honoraria for lectures from Biomarin, Immedica, and Recordati Rare Diseases Foundation, and is a co-founder of the Hospital Sant Joan de Deu start-up "Neuroprotect Life Sciences". EDAT- 2026/08/28 11:39 MHDA- 2026/08/28 11:40 PMCR- 2026/08/28 CRDT- 2026/08/27 21:35 PHST- 2026/08/10 00:00 [revised] PHST- 2026/06/02 00:00 [received] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/08/28 11:40 [medline] PHST- 2026/08/28 11:39 [pubmed] PHST- 2026/08/27 21:35 [entrez] PHST- 2026/08/28 00:00 [pmc-release] AID - JIMD70242 [pii] AID - 10.1002/jimd.70242 [doi] PST - ppublish SO - J Inherit Metab Dis. 2026 Sep;49(5):e70242. doi: 10.1002/jimd.70242. PMID- 42660602 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260904 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Aug 27 TI - Multicentre validation of paediatric weight estimation methods in Indonesian children: a comparison of length-based, habitus-adjusted and age-based approaches. LID - 10.1136/bmjpo-2026-004495 [doi] LID - e004495 AB - BACKGROUND: Accurate weight estimation in paediatric emergencies is essential for determining appropriate drug dosage and equipment sizes. In Indonesia, where emergency tapes are not widely available, the 2011 Advanced Paediatric Life Support (APLS) formula is commonly used although its accuracy in the local population remains uncertain. This study aimed to evaluate and compare the accuracy of four weight estimation methods-the 2019 Broselow Tape, the 2022 Dose-by-Growth (DbG) Tape, the 2009 Paediatric Advanced Weight Prediction in the Emergency Room (PAWPER) Tape and the 2011 APLS formula. METHODS: This multicentre cross-sectional study included 1448 Indonesian children aged 0-12 years from two major hospitals. Estimated weights using the four methods were compared with actual body weight. Agreement was assessed using Bland-Altman plots, while accuracy was evaluated using the percentage of weight estimates within 10% and 20% of actual weight (PW10 and PW20). RESULTS: The PAWPER Tape demonstrated the highest accuracy (PW20=89.4%) with low bias (mean percentage error (MPE) 4.6+/-12.8%). The Broselow Tape (MPE 5.1+/-15.9%; PW20=82.7%) and DbG Tape (MPE 7.3+/-16.0%; PW20=79.6%) showed comparable performance. In contrast, the APLS formula had substantially greater bias and lower accuracy (MPE 14.0+/-28.5%; PW20=58.8%) and demonstrated consistent overestimation across most weight categories. CONCLUSION: PAWPER Tape showed the best accuracy and agreement with measured weight in Indonesian children followed by the Broselow and DbG Tapes. In contrast, the 2011 APLS formula performed poorly, with greater error and systematic overestimation. These findings support the use of length-based and habitus-adjusted methods in paediatric emergency settings. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Puspaningtyas, Niken Wahyu AU - Puspaningtyas NW AUID- ORCID: 0000-0002-5977-1577 AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia nikenwp2020@gmail.com. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Hidayat, Sharfina Fulki Adilla AU - Hidayat SFA AUID- ORCID: 0009-0009-2505-7445 AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Tartila, Tartila AU - Tartila T AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Prawira, Yogi AU - Prawira Y AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Yuniar, Irene AU - Yuniar I AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Nathania, Ilona AU - Nathania I AUID- ORCID: 0009-0005-5667-0710 AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. AD - Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. FAU - Negoro, Fae Ilana AU - Negoro FI AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. AD - Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. FAU - Sunukanto, Jennifer S AU - Sunukanto JS AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. AD - Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. FAU - Dewi, Rismala AU - Dewi R AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260827 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Indonesia MH - Cross-Sectional Studies MH - Child, Preschool MH - Female MH - Infant MH - Male MH - *Body Weight MH - Child MH - Infant, Newborn MH - *Anthropometry/methods MH - Reproducibility of Results PMC - PMC13536096 OTO - NOTNLM OT - Child Health OT - Children OT - Cross-Sectional Studies OT - Developing Countries OT - Resuscitation COIS- Competing interests: None declared. EDAT- 2026/08/28 11:40 MHDA- 2026/08/28 11:41 PMCR- 2026/08/27 CRDT- 2026/08/27 21:12 PHST- 2026/04/09 00:00 [received] PHST- 2026/08/15 00:00 [accepted] PHST- 2026/08/28 11:41 [medline] PHST- 2026/08/28 11:40 [pubmed] PHST- 2026/08/27 21:12 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.1136/bmjpo-2026-004495 [pii] AID - bmjpo-2026-004495 [pii] AID - 10.1136/bmjpo-2026-004495 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Aug 27;10(1):e004495. doi: 10.1136/bmjpo-2026-004495. PMID- 42660285 OWN - NLM STAT- Publisher LR - 20260901 IS - 1559-2030 (Electronic) IS - 1551-7144 (Linking) VI - 170 DP - 2026 Aug 27 TI - 'eatNplay'- a family-based, telehealth intervention for childhood obesity: A randomized newsletter-controlled pilot study. PG - 108450 LID - S1551-7144(26)00236-3 [pii] LID - 10.1016/j.cct.2026.108450 [doi] AB - INTRODUCTION: Childhood obesity is a major public health concern in the United States. Telehealth interventions are a strategy to instill healthy lifestyle choices among children and their guardians by introducing and reinforcing healthy behaviors. OBJECTIVE: Our aim was to assess the feasibility of a telehealth intervention using motivational interviewing focusing on healthy behaviors in children. METHODS: Using a family-based, randomized, controlled, crossover trial design, 42 families with children aged 5-11 years were randomly assigned to an intervention group or newsletter control group. Participants were randomly divided into two groups. One group was assigned the intervention condition for four weeks (Phase-1, from the beginning of the study through 4 weeks), followed by a two-week washout period, then assigned to the newsletter control condition (Phase-2, from week 7 until the end of week 10.) The intervention consisted of weekly 'eatNplay' group telehealth sessions, conducted by a registered nurse and a motivational interviewing expert, to discuss diet, physical activity, screentime, and sleep. RESULTS: Participants' mean age was 8.8 +/- 1.8; 54% were female. Engagement scores and attendance were consistently high throughout the study. Dietary, activity, and sleep outcomes were compared to American Pediatrics Association recommendations for the age group. DISCUSSION: A telehealth intervention using motivational interviewing to address healthy behaviors in children was well received by participating families. This pilot study helped guide a planned future study that may be longer. Data from dietary intake, activity, and sleep are valuable to guide future studies. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Arce, Britney AU - Arce B AD - School of Nursing, Indiana University, United States of America. Electronic address: barce@iu.edu. FAU - Davis-Ajami, Mary Lynn AU - Davis-Ajami ML AD - College of Health, Cleveland State University, United States of America. Electronic address: m.davisajami@csuohio.edu. FAU - Ortyl, Bailey AU - Ortyl B AD - School of Public Health, Indiana University, United States of America. Electronic address: brtyl@iu.edu. FAU - Hartlieb, Kathryn AU - Hartlieb K AD - College Of Human Performance, Parker University, United States of America. Electronic address: kathrynhartlieb@parker.edu. FAU - Dickinson, Stephanie AU - Dickinson S AD - School of Public Health, Indiana University, United States of America. Electronic address: sd3@iu.edu. FAU - Golzarri-Arroyo, Lilian AU - Golzarri-Arroyo L AD - School of Public Health, Indiana University, United States of America. Electronic address: lgolzarr@iu.edu. FAU - Faith, Myles AU - Faith M AD - University at Buffalo, United States of America. Electronic address: mfaith@buffalo.edu. FAU - Jayawardene, Wasantha AU - Jayawardene W AD - School of Human Sciences, Southern Illinois University Carbondale, United States of America. Electronic address: wasantha@siu.edu. LA - eng PT - Journal Article DEP - 20260827 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 SB - IM OTO - NOTNLM OT - Exercise OT - Family-based OT - Kids OT - Pediatric OT - Telehealth OT - Wellness COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/28 11:40 MHDA- 2026/08/28 11:40 CRDT- 2026/08/27 19:11 PHST- 2026/02/12 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/08/28 11:40 [pubmed] PHST- 2026/08/28 11:40 [medline] PHST- 2026/08/27 19:11 [entrez] AID - S1551-7144(26)00236-3 [pii] AID - 10.1016/j.cct.2026.108450 [doi] PST - aheadofprint SO - Contemp Clin Trials. 2026 Aug 27;170:108450. doi: 10.1016/j.cct.2026.108450. PMID- 42659919 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260911 IS - 1873-2518 (Electronic) IS - 0264-410X (Linking) VI - 91 DP - 2026 Oct 3 TI - Muscle size matters: making paediatric vaccination safe for all - a pilot study. PG - 129076 LID - S0264-410X(26)00885-6 [pii] LID - 10.1016/j.vaccine.2026.129076 [doi] AB - BACKGROUND/OBJECTIVES: Shoulder Injury Related to Vaccine Administration (SIRVA) is an uncommon but clinically significant iatrogenic complication of vaccination, associated with improper injection depth or site selection. This pilot study aimed to evaluate the suitability of existing Australian intramuscular deltoid injection guidelines in a paediatric population and to assess the accuracy of commonly used anatomical landmarking techniques. METHODS: A cohort of 20 participants (14 male, 6 female) aged 12 months to 18 years was recruited. Real-time ultrasound was used to measure the skin-to-deltoid muscle distance and the thickness of the deltoid muscle. These measurements were compared with common external landmarking techniques. RESULTS: Only 20% of participants had sufficient tissue depth to safely accommodate a 25 mm needle. No demographic or anthropometric variables reliably predicted tissue depth. Anatomical landmarking techniques demonstrated variability in accuracy, though all were suitably close to the optimal injection site. CONCLUSIONS: These findings suggest while vaccination landmarking techniques are appropriate, current needle length guidelines in Australia appear to not be appropriate for a paediatric population, and highlight the need for more individualised, evidence-based approaches to vaccine administration. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Mackenzie, Laura Jane AU - Mackenzie LJ AD - Faculty of Health (Physiotherapy), University of Canberra, Canberra 2617, Australia. Electronic address: laura.mackenzie@canberra.edu.au. FAU - Bousie, Jaquelin Anne AU - Bousie JA AD - Faculty of Health (Physiotherapy), University of Canberra, Canberra 2617, Australia; UC Research Institute for Sport and Exercise, Canberra 2617, Australia. FAU - Newman, Phillip AU - Newman P AD - Faculty of Health (Physiotherapy), University of Canberra, Canberra 2617, Australia; UC Research Institute for Sport and Exercise, Canberra 2617, Australia. FAU - Preston, Peter AU - Preston P AD - Faculty of Health (Medical Imaging), University of Canberra, Canberra 2617, Australia. FAU - Cunningham, John Edward AU - Cunningham JE AD - Epworth Richmond, Melbourne, Australia. FAU - Fleming, Catriona AU - Fleming C AD - Austin Hospital, Heidelberg, Melbourne, Australia. FAU - Leary, Kate AU - Leary K AD - Faculty of Health (Medical Imaging), University of Canberra, Canberra 2617, Australia. FAU - Bushell, Mary-Jessimine Ann AU - Bushell MA AD - Faculty of Health (Pharmacy), University of Canberra, Canberra 2617, Australia. LA - eng PT - Journal Article DEP - 20260826 PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - 0 (Vaccines) SB - IM MH - Humans MH - Female MH - Pilot Projects MH - Male MH - Child, Preschool MH - Adolescent MH - *Vaccination/adverse effects/methods MH - Injections, Intramuscular/methods/adverse effects MH - Infant MH - Child MH - Ultrasonography MH - Australia MH - *Deltoid Muscle/anatomy & histology/diagnostic imaging MH - Vaccines/administration & dosage OTO - NOTNLM OT - Immunisation OT - Intramuscular injection OT - Paediatrics OT - SIRVA OT - Vaccination COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/28 11:40 MHDA- 2026/09/11 23:36 CRDT- 2026/08/27 18:08 PHST- 2026/06/11 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/11 23:36 [medline] PHST- 2026/08/28 11:40 [pubmed] PHST- 2026/08/27 18:08 [entrez] AID - S0264-410X(26)00885-6 [pii] AID - 10.1016/j.vaccine.2026.129076 [doi] PST - ppublish SO - Vaccine. 2026 Oct 3;91:129076. doi: 10.1016/j.vaccine.2026.129076. Epub 2026 Aug 26. PMID- 42658485 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261016 IS - 1878-6448 (Electronic) IS - 1053-8135 (Linking) VI - 59 IP - 3 DP - 2026 Nov TI - Autonomic Dysfunction After Pediatric Concussion: A Scoping Review. PG - 343-363 LID - 10.1177/10538135261479313 [doi] AB - PurposeA concussion is a common injury in children and adolescents. Despite how common these brain injuries are, relatively little is known about the underlying pathophysiology of pediatric concussion. This scoping review aims to collect and synthesize the literature on autonomic dysfunction (AD) in pediatric concussion, with a secondary aim to identify the procedures and measures testing autonomic function (AF).MethodsWe completed a systematic search using six databases of articles pertaining to AD after concussion. The resulting articles were exported, screened, and reviewed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) guidelines.ResultsTwenty-two studies met the study criteria and were included in the review. Findings revealed that children and adolescents experience varying degrees of AD after concussion. Fifteen of the 22 studies identified some anomaly related to AD in the concussed pediatric population, though the direction of findings varied across studies and injury phases. The most common autonomic assessment used in studies focused on cardiovascular autonomic reflex testing resulting from orthostatic stressors (n = 10), with other measures including respiratory effects during aerobic exercise and ocular dynamics.ConclusionOverall, there is a gap in our understanding of AD after pediatric concussion. The findings of this study provide mixed results on AD after pediatric concussion. Future research should prioritize prospective studies examining autonomic recovery trajectories across developmental subgroups. Autonomic measures, such as cardioregulatory measures and pupillometry, represent promising emerging markers that require further validation to inform rehabilitation protocols in pediatric concussion. FAU - Ramsay, Scott AU - Ramsay S AUID- ORCID: 0000-0001-5427-219X AD - School of Nursing, University of British Columbia, Vancouver, Canada. RINGGOLD: 8166 AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada. AD - BC Children's Hospital Research Institute, Vancouver, Canada. RINGGOLD: 512469 FAU - Lloyd, Hunter AU - Lloyd H AD - School of Nursing, University of British Columbia, Vancouver, Canada. RINGGOLD: 8166 AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada. FAU - Kobzeva, Violetta AU - Kobzeva V AD - School of Nursing, University of British Columbia, Vancouver, Canada. RINGGOLD: 8166 FAU - Lee, James AU - Lee J AD - BC Children's Hospital Research Institute, Vancouver, Canada. RINGGOLD: 512469 AD - Department of Pediatrics, University of British Columbia, Vancouver, Canada. RINGGOLD: 8166 LA - eng PT - Journal Article PT - Review PT - Scoping Review DEP - 20260827 PL - United States TA - NeuroRehabilitation JT - NeuroRehabilitation JID - 9113791 SB - IM MH - Humans MH - *Autonomic Nervous System Diseases/etiology/physiopathology MH - *Brain Concussion/complications/physiopathology MH - Child MH - Adolescent MH - Autonomic Nervous System/physiopathology OTO - NOTNLM OT - adolescent OT - autonomic nervous system OT - brain concussion OT - child OT - parasympathetic nervous system OT - sympathetic nervous system COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/27 17:37 MHDA- 2026/10/08 17:35 CRDT- 2026/08/27 11:26 PHST- 2026/10/08 17:35 [medline] PHST- 2026/08/27 17:37 [pubmed] PHST- 2026/08/27 11:26 [entrez] AID - 10.1177/10538135261479313 [doi] PST - ppublish SO - NeuroRehabilitation. 2026 Nov;59(3):343-363. doi: 10.1177/10538135261479313. Epub 2026 Aug 27. PMID- 42658375 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20261008 IS - 1573-3327 (Electronic) IS - 0009-398X (Linking) VI - 57 IP - 5 DP - 2026 Oct TI - Evaluation of Oral Health in Children with Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Study. PG - 1275-1283 LID - 10.1007/s10578-026-02091-7 [doi] AB - This study aimed to compare the oral health profiles of children with Attention-Deficit/Hyperactivity Disorder (ADHD) and healthy controls, focusing on caries experience, periodontal status, and occlusal characteristics. In this cross-sectional study, children aged 10-18 years diagnosed with ADHD (n = 50) and age-matched healthy controls (n = 50) underwent standardized dental examinations. ADHD diagnoses were established by a child and adolescent psychiatry specialist based on DSM-5 criteria and supported by neuropsychological assessments. All dental evaluations were performed by a single blinded examiner under standardized clinical conditions. Assessments included DMFT scoring, clinical gingival evaluation, malocclusion analysis, dental crowding status, and panoramic radiographic evaluation. Children with ADHD had a significantly higher DMFT index than controls (2.82 +/- 1.38 vs. 1.10 +/- 1.02; p < 0.001). The odds of having a fractured tooth were higher in the ADHD group than in the control group (36% vs. 10%; unadjusted OR = 5.06, 95% CI: 1.70-15.05; p = 0.004). Any gingival abnormality was more frequent in the ADHD group than in the control group (60% vs. 12%; unadjusted OR = 11.00, 95% CI: 3.95-30.61; p < 0.001). Malocclusion (64% vs. 24%; p < 0.001) and dental crowding (70% vs. 44%; p = 0.015) were also more frequent among children with ADHD. Within this selected sample meeting predefined oral-hygiene, dietary, and dental-attendance criteria, ADHD was associated with poorer oral health indicators. These findings provide clinically relevant insights and may support tailored preventive monitoring and clinically indicated dental-mental health collaboration. Further studies involving larger and more diverse cohorts are warranted to validate these associations across the broader ADHD population. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Jaicks, Caglar Charles Daniel AU - Jaicks CCD AUID- ORCID: 0000-0003-4428-6912 AD - Child and Adolescent Psychiatry Department, Istanbul Aydin University, Istanbul, Turkey. caglarjaicks@yahoo.com. FAU - Kinter, Reyhan Calisan AU - Kinter RC AD - Child and Adolescent Psychiatry Department, Istanbul Aydin University, Istanbul, Turkey. FAU - Yeniugurel, Turgay AU - Yeniugurel T AD - Private Dental Clinic, Adana, Turkey. FAU - Yildirim, Cemile AU - Yildirim C AD - Private Psychological Counseling Clinic, Adana, Turkey. LA - eng PT - Journal Article DEP - 20260827 PL - United States TA - Child Psychiatry Hum Dev JT - Child psychiatry and human development JID - 1275332 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/epidemiology/complications MH - Child MH - Cross-Sectional Studies MH - Male MH - Female MH - *Oral Health/statistics & numerical data MH - Adolescent MH - DMF Index MH - *Malocclusion/epidemiology MH - *Dental Caries/epidemiology OTO - NOTNLM OT - ADHD OT - Dental caries OT - Malocclusion OT - Oral health OT - Pediatric dentistry COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/08/27 17:35 MHDA- 2026/09/26 05:34 CRDT- 2026/08/27 11:22 PHST- 2026/01/08 00:00 [received] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/08/27 17:35 [pubmed] PHST- 2026/08/27 11:22 [entrez] AID - 10.1007/s10578-026-02091-7 [pii] AID - 10.1007/s10578-026-02091-7 [doi] PST - ppublish SO - Child Psychiatry Hum Dev. 2026 Oct;57(5):1275-1283. doi: 10.1007/s10578-026-02091-7. Epub 2026 Aug 27. PMID- 42658263 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260928 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 6 DP - 2026 Aug 27 TI - Oral iron-induced stunting is associated with increased Christensenella abundance in a piglet model for human infants. LID - 10.1007/s00394-026-04082-9 [doi] LID - 243 AB - PURPOSE: Iron deficiency anaemia (IDA) affects around 40% of < 5-year-olds globally. Unfortunately, IDA treatment by oral iron intervention often causes diarrhoea, thought to be linked to iron-induced changes in the gut microbiota. Piglets are valuable preclinical models for human infants since they share many physiological characteristics, have similar gut microbial populations and, if left untreated with iron, reliably develop IDA. We hypothesised that IDA and different forms of iron supplementation (oral and injection) would have differential effects on the gut microbiota that would consequently differentially impact immune and metabolic development during infancy. METHODS: 24 one-day-old piglets were litter-matched into 4 treatment groups (n = 6): control (no iron); intramuscular iron (IM, 200mg Fe); oral iron (200mg FeSO(4)/kg feed); IM+oral iron combined. RESULTS: As expected, the iron-free treatment piglets developed IDA. This was combined with stunted growth and corresponding changes in plasma metabolites and immune parameters. However, although all 3 iron treatments prevented the development of IDA, piglets receiving oral iron were also stunted (compared to those which received IM iron; 14-19% weight-gain reduction over 27 days, p<0.05). This stunting was linked to significant changes in the expression of immune-associated proteins in the gut and specific bacterial genera, but not plasma metabolites. Importantly, the correlation between oral-iron treatment, reduced weight gain and increased Christensenella abundance provides novel evidence linking iron-induced stunting with Christensenella. CONCLUSION: The findings relayed here thus raise health concerns for infants receiving iron-fortified formula milk and/or those in LMICs enrolled in blanket oral iron supplementation programs. CI - (c) 2026. The Author(s). FAU - Abbas, Munawar AU - Abbas M AD - Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UK. AD - Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland. FAU - Batool, Maria AU - Batool M AD - Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UK. FAU - Hayirli, Zeynep AU - Hayirli Z AD - Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UK. FAU - Poveda, Carlos AU - Poveda C AD - Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UK. FAU - Karatzas, Kimon-Andreas AU - Karatzas KA AD - Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UK. FAU - Walton, Gemma E AU - Walton GE AD - Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UK. FAU - Ijaz, Umer Zeeshan AU - Ijaz UZ AD - Mazumdar-Shaw Advanced Research Centre, University of Glasgow, Glassgow, UK. AD - Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK. AD - College of Science and Engineering, University of Galway, Galway, Ireland. FAU - Andrews, Simon C AU - Andrews SC AD - School of Biological Sciences, University of Reading, Whiteknights, Reading, UK. FAU - Lewis, Marie C AU - Lewis MC AD - Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UK. marie.lewis@reading.ac.uk. LA - eng PT - Journal Article DEP - 20260827 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 RN - E1UOL152H7 (Iron) RN - 0 (Iron, Dietary) SB - IM MH - Animals MH - *Anemia, Iron-Deficiency/microbiology MH - Swine MH - Administration, Oral MH - Dietary Supplements MH - Disease Models, Animal MH - Animals, Newborn MH - *Gastrointestinal Microbiome/drug effects MH - *Growth Disorders/chemically induced/microbiology/etiology MH - *Eubacteriales/growth & development/isolation & purification MH - *Iron/administration & dosage/adverse effects MH - Humans MH - *Iron, Dietary/administration & dosage/adverse effects MH - Female MH - Weight Gain MH - Injections, Intramuscular PMC - PMC13521992 OTO - NOTNLM OT - Gut microbiota OT - Immune development OT - Iron deficiency OT - Iron deficiency anaemia OT - Iron supplementation OT - Piglet models COIS- Declarations. Conflict of interest: The authors declare no conflict of interests. EDAT- 2026/08/27 17:35 MHDA- 2026/08/27 17:36 PMCR- 2026/08/27 CRDT- 2026/08/27 11:14 PHST- 2026/04/27 00:00 [received] PHST- 2026/08/01 00:00 [accepted] PHST- 2026/08/27 17:36 [medline] PHST- 2026/08/27 17:35 [pubmed] PHST- 2026/08/27 11:14 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.1007/s00394-026-04082-9 [pii] AID - 4082 [pii] AID - 10.1007/s00394-026-04082-9 [doi] PST - epublish SO - Eur J Nutr. 2026 Aug 27;65(6):243. doi: 10.1007/s00394-026-04082-9. PMID- 42656734 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260828 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - Internet Gaming Addiction in Children and Adolescents: A Narrative Review in the Context of Screen Time. PG - e113441 LID - 10.7759/cureus.113441 [doi] LID - e113441 AB - Internet gaming addiction in children and adolescents is an emerging clinical and public health concern within the broader context of increasing recreational screen exposure. Despite growing recognition of gaming disorder, uncertainty remains regarding its distinction from high recreational gaming, its relationship with screen time, and the most appropriate prevention and management strategies for pediatric populations. This narrative review aimed to synthesise evidence published between 2013 and 2026 on diagnostic concepts, epidemiological patterns, screen-time context, mental and physical health associations, and intervention approaches for problematic gaming in children and adolescents. Relevant literature was reviewed and organised into diagnostic, clinical, public health, and therapeutic domains. The conclusions were derived from qualitative narrative synthesis rather than pooled quantitative analysis. Current evidence indicates that gaming disorder should not be defined by screen-time duration alone, but by impaired control, persistence despite harm, prioritisation of gaming over essential activities, and functional impairment across academic, social, developmental, and family domains. Prevalence estimates vary because of differences in diagnostic criteria, assessment tools, cultural gaming practices, and study populations. Excessive gaming commonly overlaps with emotional symptoms, sleep disturbance, sedentary behaviour, reduced physical activity, academic difficulties, social withdrawal, and family conflict. Available evidence suggests potential benefit from multidimensional management involving validated assessment, cognitive behavioural strategies, relapse prevention, parental involvement, school-based digital literacy, structured offline activities, and coordinated pediatric mental health care. Screen-time reduction is important, but restriction alone is insufficient. Given the absence of formal evidence grading and risk-of-bias assessment, conclusions regarding intervention effectiveness should be interpreted cautiously. Pediatric gaming disorder requires impairment-based assessment and developmentally appropriate, family-supported intervention rather than simple screen-time control. CI - Copyright (c) 2026, Sharma et al. FAU - Sharma, Neena AU - Sharma N AD - Department of Physiology, All India Institute of Medical Sciences (AIIMS), Jammu, Jammu, IND. LA - eng PT - Journal Article PT - Review DEP - 20260727 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13508007 OTO - NOTNLM OT - adolescents OT - gaming disorder OT - internet gaming addiction OT - pediatric mental health OT - screen time COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/27 12:36 MHDA- 2026/08/27 12:37 PMCR- 2026/07/27 CRDT- 2026/08/27 06:08 PHST- 2026/07/24 00:00 [accepted] PHST- 2026/08/27 12:37 [medline] PHST- 2026/08/27 12:36 [pubmed] PHST- 2026/08/27 06:08 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.7759/cureus.113441 [doi] PST - epublish SO - Cureus. 2026 Jul 27;18(7):e113441. doi: 10.7759/cureus.113441. eCollection 2026 Jul. PMID- 42656511 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260828 IS - 2347-5625 (Print) IS - 2349-6673 (Electronic) IS - 2347-5625 (Linking) VI - 13 DP - 2026 Dec TI - Development and preliminary validation of the Exercise Fit Tool for adolescents undergoing cancer treatment in Hong Kong. PG - 101005 LID - 10.1016/j.apjon.2026.101005 [doi] LID - 101005 AB - OBJECTIVE: This study aimed to develop and preliminarily validate the Exercise Fit Tool (EFT), a patient-reported self-assessment tool for adolescents undergoing cancer treatment in Hong Kong. METHODS: A convenience sample of 158 adolescents aged 13-18 years who were undergoing cancer treatment and could communicate in Cantonese and read Chinese was recruited in Hong Kong. Instrument development followed the procedures recommended in AMEE Guide No. 87. Candidate items were generated from a literature review and focus groups with adolescents and healthcare professionals, refined by an expert panel, assessed for content validity, and revised through cognitive interviews. Pilot testing was conducted in 158 adolescents. Convergent validity was examined using pain scores and forced expiratory volume in 1 second (FEV1, % predicted), and criterion-related validity was evaluated by comparing EFT scores with physiotherapists' ratings. Test-retest reliability was assessed in 50 participants, and principal component analysis with Varimax rotation was performed. RESULTS: The final 10-item EFT demonstrated satisfactory content validity, with I-CVIs ranging from 0.86 to 1.00, and good internal consistency (Cronbach's alpha = 0.92). The 2-week test-retest ICC was 0.82 (P < 0.001). EFT scores were negatively correlated with pain scores and positively correlated with FEV1 (% predicted), supporting convergent validity. The Kaiser-Meyer-Olkin measure was 0.87, and Bartlett's test of sphericity was significant (P < 0.001). Principal component analysis identified a two-component solution: cancer- and treatment-related influences on physical activity (7 items; Cronbach's alpha = 0.96; 55.7% of the rotated variance) and perceived physical activity exertion (3 items; Cronbach's alpha = 0.74; 20.6% of the rotated variance). Primary component loadings ranged from 0.74 to 0.93, and communalities ranged from 0.55 to 0.91. The two components explained 76.3% of the total variance. CONCLUSIONS: The EFT demonstrated preliminary evidence of validity and reliability for adolescents undergoing cancer treatment in Hong Kong. Further evaluation of its latent structure and implementation in independent samples is required before wider clinical use. CI - (c) 2026 The Author(s). FAU - Lam, Katherine Ka Wai AU - Lam KKW AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Wu, Stanley AU - Wu S AD - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China. FAU - Liu, Qi AU - Liu Q AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Mao, Ting AU - Mao T AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Pan, Jingda AU - Pan J AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Jiang, Lulu AU - Jiang L AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Li, Yanjia AU - Li Y AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Gao, Yuwen AU - Gao Y AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Cheng, Frankie Wai Tsoi AU - Cheng FWT AD - Hong Kong Children's Hospital, Hong Kong SAR, China. FAU - Chan, Godfrey Chi Fung AU - Chan GCF AD - Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong, Hong Kong SAR, China. FAU - Ho, Ka Yan AU - Ho KY AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. LA - eng PT - Journal Article DEP - 20260711 PL - United States TA - Asia Pac J Oncol Nurs JT - Asia-Pacific journal of oncology nursing JID - 101673157 PMC - PMC13506534 OTO - NOTNLM OT - Adolescents OT - Cancer OT - Patient-reported outcome OT - Physical activity OT - Reliability OT - Validation COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 12:36 MHDA- 2026/08/27 12:37 PMCR- 2026/07/11 CRDT- 2026/08/27 05:40 PHST- 2025/11/11 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/27 12:37 [medline] PHST- 2026/08/27 12:36 [pubmed] PHST- 2026/08/27 05:40 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - S2347-5625(26)00155-1 [pii] AID - 101005 [pii] AID - 10.1016/j.apjon.2026.101005 [doi] PST - epublish SO - Asia Pac J Oncol Nurs. 2026 Jul 11;13:101005. doi: 10.1016/j.apjon.2026.101005. eCollection 2026 Dec. PMID- 42654495 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 8 DP - 2026 Aug 20 TI - Maternal Vulnerability Indicators Derived from Free-Text Clinical Documentation in Adolescent Pregnancy. LID - 10.3390/medicina62081598 [doi] LID - 1598 AB - Background and Objectives: Adolescent pregnancy is associated with biological, behavioral, and healthcare-related vulnerabilities that are incompletely captured by structured datasets. This study aimed to characterize selected maternal vulnerability indicators derived from narrative clinical documentation and to examine their exploratory associations with documented prenatal care deficiency and neonatal outcomes. Materials and Methods: We conducted a retrospective cohort study including 759 singleton adolescent pregnancies managed at a Romanian secondary obstetric center between 2020 and 2024. Narrative clinical observations were reviewed to extract maternal vulnerability indicators, including smoking, anemia, infection, hypertensive disorders, obesity, Rh incompatibility, and documented prenatal care deficiency. Associations between extracted variables, documented prenatal care deficiency, and neonatal outcomes were evaluated using contingency analyses, Kendall's tau-b correlations, and multivariable logistic regression models. Results: Among pregnancies with available narrative observations, documented prenatal care deficiency was identified in 612/692 (88.4%), maternal anemia in 207/692 (29.9%), and smoking during pregnancy in 186/692 (26.9%). Validation performance differed across categories, with a sensitivity of 57.1% (95% CI 18.4-90.1%) for hypertensive disorders and wide confidence intervals for rare categories. Correlations between extracted variables were weak, indicating limited clustering of maternal risk factors. Hypertensive disorders (aOR 0.31, 95% CI 0.10-0.95, p = 0.038) and maternal obesity (aOR 0.39, 95% CI 0.16-0.98, p = 0.044) were associated with lower odds of documented prenatal care deficiency. Significant neonatal associations were observed primarily for low birth weight. Hypertensive disorders were independently associated with increased odds of low birth weight (aOR 3.56, 95% CI 1.33-9.54, p = 0.011), whereas documented maternal anemia was associated with lower observed odds of LBW (aOR 0.45, 95% CI 0.24-0.82, p = 0.009). No significant associations were identified for preterm birth or Apgar score < 7 at 5 min. Conclusions: Narrative clinical documentation allowed the identification of heterogeneous maternal vulnerability indicators that showed weak interrelationships and selective associations with prenatal surveillance patterns and low birth weight. These exploratory findings should be interpreted in the context of healthcare engagement and documentation practices. FAU - Sandor, Florin Mihai AU - Sandor FM AUID- ORCID: 0009-0008-4137-7388 AD - Multidisciplinary Doctoral School, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. AD - Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Precup, Cris Virgiliu AU - Precup CV AUID- ORCID: 0009-0009-4299-5652 AD - Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Furau, Cristian George AU - Furau CG AUID- ORCID: 0000-0001-7158-2579 AD - Multidisciplinary Doctoral School, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. AD - Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Edu, Antoine AU - Edu A AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Nicolae Malaxa Clinical Hospital, 022441 Bucharest, Romania. FAU - Edu, Mihnea-Dan AU - Edu MD AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Nicolae Malaxa Clinical Hospital, 022441 Bucharest, Romania. FAU - Coroleuca, Ciprian AU - Coroleuca C AUID- ORCID: 0000-0002-2043-9307 AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Panait Sarbu Clinical Hospital of Obstetrics and Gynecology, 060251 Bucharest, Romania. FAU - Furau, Roxana AU - Furau R AD - Department of General Medicine, Faculty of Medicine, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Rosca, Ioana AU - Rosca I AUID- ORCID: 0009-0002-4629-5820 AD - Panait Sarbu Clinical Hospital of Obstetrics and Gynecology, 060251 Bucharest, Romania. AD - Faculty of Midwifery and Nursery, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. FAU - Mateescu, Radu Nicolae AU - Mateescu RN AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Nicolae Malaxa Clinical Hospital, 022441 Bucharest, Romania. LA - eng PT - Journal Article DEP - 20260820 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adolescent MH - Retrospective Studies MH - *Pregnancy in Adolescence/statistics & numerical data MH - Romania/epidemiology MH - *Prenatal Care/statistics & numerical data/standards MH - Cohort Studies MH - *Documentation/methods/statistics & numerical data/standards MH - Pregnancy Complications/epidemiology MH - Risk Factors MH - Logistic Models MH - Pregnancy Outcome/epidemiology MH - Infant, Newborn PMC - PMC13515706 OTO - NOTNLM OT - adolescent pregnancy OT - low birth weight OT - maternal vulnerability OT - narrative clinical documentation OT - perinatal epidemiology OT - prenatal care deficiency OT - routinely collected health data COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:10 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - medicina62081598 [pii] AID - medicina-62-01598 [pii] AID - 10.3390/medicina62081598 [doi] PST - epublish SO - Medicina (Kaunas). 2026 Aug 20;62(8):1598. doi: 10.3390/medicina62081598. PMID- 42654307 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 20 TI - Social Media and out of Home Food Selection and Health Promoting Choices: A Generational Perspective in Poland. LID - 10.3390/nu18162727 [doi] LID - 2727 AB - OBJECTIVE: This study investigates the relationship between social media use and consumer purchase intentions or out-of-home food choices in the Polish gastronomic market, focusing specifically on variations across generations. METHODOLOGY: Data were collected between May and July 2024 through a diagnostic survey using the Computer-Assisted Web Interviewing (CAWI) technique (N = 1099). Respondents were recruited via a non-probability quota sampling approach based on strict demographic inclusion criteria. To test the research hypotheses regarding generational variations in market behaviour, a multivariate discriminant function analysis was performed using Statistica 13.1 PL. A preliminary pilot study (N = 30) confirmed the initial questionnaire readability and overall consistency (Cronbach's alpha = 0.87), while subscales were treated independently during the main analysis. RESULTS: Multivariate models were found to be highly significant, revealing clear differences between age groups. The youngest cohort (aged 18-35) relies heavily on Instagram and TikTok, showing distinct patterns regarding visual triggers such as "instagrammable" aesthetics, digital validation, and menu uniqueness alongside weight loss claims. Conversely, seniors (aged 61 and older) lean unexpectedly towards X. This older segment displays pragmatic, utility-driven motives, searching for detailed textual data about ingredients and the health-promoting properties of food. General product quality and calorie control were identified as universal factors that do not vary by generation. Conclusions and Managerial Implications: The digital transformation of the Polish restaurant industry does not follow a single path. Social media is closely linked to modern customer journeys, with physical dining spots frequently serving as spaces for socialisation. Consequently, restaurant operators should move away from mass communication and adopt a selective omnichannel strategy, where message formats shift from visual appeal to factual, nutrition-oriented text that is tailored to the digital literacy and dietary needs of each generation. FAU - Soroka, Andrzej AU - Soroka A AD - Faculty of Medical and Health Sciences, University of Siedlce, Boleslawa. Prusa 14, 08-110 Siedlce, Poland. FAU - Godlewska, Agnieszka AU - Godlewska A AD - Faculty of Medical and Health Sciences, University of Siedlce, Boleslawa. Prusa 14, 08-110 Siedlce, Poland. FAU - Mazurek-Kusiak, Anna Katarzyna AU - Mazurek-Kusiak AK AUID- ORCID: 0000-0002-3786-8861 AD - Department of Tourism and Recreation, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland. LA - eng GR - 233/26/B/Ministry of Science and Higher Education/ PT - Journal Article DEP - 20260820 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Poland MH - *Food Preferences/psychology MH - *Social Media/statistics & numerical data MH - Female MH - Middle Aged MH - Adult MH - *Consumer Behavior/statistics & numerical data MH - *Choice Behavior MH - Male MH - Adolescent MH - *Health Promotion MH - Young Adult MH - Surveys and Questionnaires MH - Aged MH - Digital Media PMC - PMC13516072 OTO - NOTNLM OT - consumer behaviour OT - discriminant function analysis OT - food choices OT - gastronomic market OT - intergenerational differences OT - social media COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:10 PHST- 2026/07/15 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - nu18162727 [pii] AID - nutrients-18-02727 [pii] AID - 10.3390/nu18162727 [doi] PST - epublish SO - Nutrients. 2026 Aug 20;18(16):2727. doi: 10.3390/nu18162727. PMID- 42654292 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 19 TI - Reproducibility of a 69-Item School Children's Food Frequency Questionnaire (69-Item SCh-FFQ) and Diet Quality Scores Among Polish Children Aged 7-9 Years. LID - 10.3390/nu18162712 [doi] LID - 2712 AB - Background/Objectives: Reliable dietary assessment tools are essential for evaluating dietary habits and diet quality in children. The aim of this study was to assess the reproducibility of a 69-item School Children's Food Frequency Questionnaire (69-item SCh-FFQ) and the diet quality scores among Polish children aged 7-9 years. Methods: The reproducibility study was conducted among 77 children. The 69-item SCh-FFQ was administered twice (test and retest). Data on food consumption frequency were used to evaluate two diet quality scores: the pro-Healthy Diet Index (pHDI) and the non-Healthy Diet Index (nHDI). The reproducibility of the 69-item SCh-FFQ and the diet quality scores was evaluated using comparisons of mean values, cross-classification analysis, Cohen's kappa statistic, Spearman's rank correlation coefficient, intraclass correlation coefficient (ICC), and Bland-Altman analysis. Results: No significant differences were observed between test and retest of the FFQ for mean values of the pHDI (2.9 +/- 1.8 vs. 2.8 +/- 1.9 points; p = 0.124) or the nHDI (4.3 +/- 1.5 vs. 4.2 +/- 1.5 points; p = 0.611). Total agreement for the classification of children into categories of the diet quality scores reached 81.8% for pHDI and 75.3% for nHDI, with low gross misclassification rates (1.3% and 0.0%, respectively). Cohen's kappa statistic indicated moderate to good agreement (kappa = 0.68 for pHDI and kappa = 0.51 for nHDI). For all food items, total agreement ranged from 66.2% to 94.8%, while the kappa statistic ranged from 0.56 to 0.81. Strong correlations and good agreement were observed between repeated measurements for both pHDI (r = 0.748, ICC = 0.778; p < 0.001) and nHDI (r = 0.783, ICC = 0.752; p < 0.001). Bland-Altman analysis demonstrated good agreement and no evidence of proportional bias. Conclusions: The 69-item SCh-FFQ demonstrated satisfactory reproducibility for assessing food consumption frequency and diet quality scores in children aged 7-9 years. Therefore, this questionnaire is a promising tool for future epidemiological studies among early school-aged children, although its utility should be confirmed in further validation studies using an appropriate reference method. FAU - Sobas, Kamila AU - Sobas K AUID- ORCID: 0000-0003-4246-6944 AD - Institute of Health Sciences, Medical College, Jan Kochanowski University, 5 Zeromskiego Street, 25-369 Kielce, Poland. FAU - Kowalkowska, Joanna AU - Kowalkowska J AUID- ORCID: 0000-0003-1981-7320 AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, 10-718 Olsztyn, Poland. FAU - Suliga, Edyta AU - Suliga E AUID- ORCID: 0000-0003-3063-0380 AD - Institute of Health Sciences, Medical College, Jan Kochanowski University, 5 Zeromskiego Street, 25-369 Kielce, Poland. AD - Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36A Postepu Street, 05-552 Magdalenka, Poland. FAU - Wadolowska, Lidia AU - Wadolowska L AUID- ORCID: 0000-0001-8571-9935 AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, 10-718 Olsztyn, Poland. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Reproducibility of Results MH - Poland MH - Female MH - Male MH - *Feeding Behavior MH - *Diet Surveys MH - *Nutrition Assessment MH - Surveys and Questionnaires MH - *Diet MH - *Diet, Healthy PMC - PMC13516586 OTO - NOTNLM OT - diet quality OT - dietary assessment OT - food consumption frequency OT - reliability OT - school-aged children COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/19 CRDT- 2026/08/27 01:10 PHST- 2026/07/02 00:00 [received] PHST- 2026/08/17 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - nu18162712 [pii] AID - nutrients-18-02712 [pii] AID - 10.3390/nu18162712 [doi] PST - epublish SO - Nutrients. 2026 Aug 19;18(16):2712. doi: 10.3390/nu18162712. PMID- 42654285 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 19 TI - Human Milk Sodium Monitoring Across the Continuum of Lactation: From Secretory Activation to Established Lactation. LID - 10.3390/nu18162705 [doi] LID - 2705 AB - Background: Human milk sodium (Na) concentration is a biomarker of lactation physiology and secretory activation, but conventional measurement methods are impractical for routine breastfeeding support. Portable Na analyzers may enable real-time home monitoring. Objective: The purpose of this study was to characterize longitudinal changes in human milk Na concentrations during the first 3 postpartum months and to evaluate the feasibility of longitudinal home Na monitoring throughout established lactation. Methods: Nine healthy lactating mothers intending to breastfeed were recruited at a breastfeeding management clinic in Tokyo, Japan, between August 2025 and December 2025. Participants performed home-based Na measurements from both breasts from birth through approximately 100 days postpartum, with the planned monitoring schedule defined as 90 postpartum days for adherence assessment. Each measurement required 2-3 drops of milk and was completed within 1 min. Longitudinal Na trajectories and Na elevation episodes were evaluated. Results: Na concentrations were highest immediately after birth and declined rapidly during the first postpartum week. Six of nine participants (66.7%) reached concentrations below 413.8 ppm within the first 7 postpartum days, and five of nine (55.6%) reached concentrations below 220 ppm by postpartum day 8. During established lactation, 62 breast-level Na elevation episodes were identified, with substantial interindividual variation in frequency and duration. Some episodes occurred without overt breast symptoms. Frequent home monitoring detected transient physiological fluctuations that would likely have been missed by conventional intermittent sampling. Conclusions: Longitudinal home milk Na monitoring was feasible in this small pilot cohort and enabled characterization of Na fluctuations from secretory activation through established lactation. These findings are preliminary and hypothesis-generating, and larger prospective studies are required to determine the clinical utility of longitudinal Na monitoring for breastfeeding assessment. FAU - Mizuno, Katsumi AU - Mizuno K AUID- ORCID: 0000-0002-6983-8851 AD - Department of Pediatrics, Showa Medical University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. FAU - Himi, Tomoko AU - Himi T AD - The Oketani Breastfeeding Management Research Institute, 20-8, Kikuicho, Shinjuku-ku, Tokyo 162-0044, Japan. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 9NEZ333N27 (Sodium) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Milk, Human/chemistry MH - *Lactation/physiology/metabolism MH - *Sodium/analysis/metabolism MH - Adult MH - Breast Feeding MH - Longitudinal Studies MH - Postpartum Period MH - Biomarkers/analysis MH - Infant, Newborn PMC - PMC13516742 OTO - NOTNLM OT - home monitoring OT - human milk OT - lactation support OT - secretory activation OT - sodium COIS- HORIBA Ltd. provided the portable sodium analyzer used in this study on loan. The company had no role in the study design, data collection, data analysis, interpretation of the data, manuscript preparation, or the decision to submit the manuscript for publication. The authors declare no other conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 12:35 PMCR- 2026/08/19 CRDT- 2026/08/27 01:10 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/15 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 12:35 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - nu18162705 [pii] AID - nutrients-18-02705 [pii] AID - 10.3390/nu18162705 [doi] PST - epublish SO - Nutrients. 2026 Aug 19;18(16):2705. doi: 10.3390/nu18162705. PMID- 42654276 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 18 TI - Assessment of Dietary Soy Isoflavones Intake Among Women Aged 14 Years and Older in China: A Population-Based Cross-Sectional Study. LID - 10.3390/nu18162696 [doi] LID - 2696 AB - Objective: This study assessed dietary soy isoflavone (SIF) intake among Chinese women >/=14 years, identified determinants, and evaluated adequacy against the Specific Proposed Level (SPL) in Chinese Dietary Reference Intakes, to inform targeted guidance. Methods: Intake was estimated using a distribution model combining 2017-2020 China National Food Consumption Survey data with SIF concentrations from food composition tables. Demographic differences and adequacy versus age-specific SPL were examined; supplemental doses were calculated for individuals below SPL. Results: Mean SIF intake was 14.77 mg/standard person-day, generally low. Significant differences (p < 0.05) were observed across most demographic subgroups except education. Higher mean intakes (mg/day) were seen in women aged >/=65 years (16.20), rural residents (16.38), light activity level (15.17), annual income > 100,000 CNY (15.51), manual laborers (16.11), and central China residents (highest, 21.01). Dried legumes and products, particularly tofu and its derivatives, contributed about 80% of total intake, with tofu-derived items accounting for 57.62-71.49%. Across all age groups, intake was significantly below the SPL, with >96% of participants failing to meet the recommendation. To reach the SPL, premenopausal women require ~40 mg/day supplemental SIF (equivalent to ~45 g soybeans/products), while perimenopausal and postmenopausal women require ~60 mg/day (~60 g soybeans/products). Conclusions: Dietary SIF intake among Chinese women >/=14 years is substantially below the SPL, a deficit that may attenuate associated health benefits. As dried beans and bean products are the dominant contributors, promoting these foods represents a feasible strategy to improve population-level SIF adequacy. FAU - Shi, Qiuyan AU - Shi Q AUID- ORCID: 0009-0008-8205-557X AD - School of Public Health, Hebei Medical University, Shijiazhuang 050017, China. AD - NHC Key Lab of Food Safety Risk Assessment, Research Unit of Food Safety, Chinese Academy of Medical Sciences (No. 2019RU014), China National Center for Food Safety Risk Assessment (CFSA), Beijing 100022, China. FAU - Zhao, Fanglei AU - Zhao F AUID- ORCID: 0000-0001-5750-2245 AD - NHC Key Lab of Food Safety Risk Assessment, Research Unit of Food Safety, Chinese Academy of Medical Sciences (No. 2019RU014), China National Center for Food Safety Risk Assessment (CFSA), Beijing 100022, China. FAU - Pan, Feng AU - Pan F AD - NHC Key Lab of Food Safety Risk Assessment, Research Unit of Food Safety, Chinese Academy of Medical Sciences (No. 2019RU014), China National Center for Food Safety Risk Assessment (CFSA), Beijing 100022, China. FAU - Luan, Dechun AU - Luan D AD - Institute of Nutrition and Food Hygiene, Liaoning Provincial Center for Disease Control and Prevention, Shenyang, 110172, China. FAU - Li, Jianwen AU - Li J AD - School of Public Health, Hebei Medical University, Shijiazhuang 050017, China. AD - NHC Key Lab of Food Safety Risk Assessment, Research Unit of Food Safety, Chinese Academy of Medical Sciences (No. 2019RU014), China National Center for Food Safety Risk Assessment (CFSA), Beijing 100022, China. FAU - Ma, Yuxia AU - Ma Y AUID- ORCID: 0000-0002-3926-2644 AD - School of Public Health, Hebei Medical University, Shijiazhuang 050017, China. LA - eng PT - Journal Article DEP - 20260818 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Isoflavones) SB - IM MH - Humans MH - Female MH - *Isoflavones/administration & dosage/analysis MH - China MH - Cross-Sectional Studies MH - Aged MH - Middle Aged MH - Adult MH - Adolescent MH - Young Adult MH - *Diet MH - Recommended Dietary Allowances MH - *Soy Foods MH - *Glycine max/chemistry MH - Diet Surveys PMC - PMC13517065 OTO - NOTNLM OT - Chinese women OT - dietary intake OT - food contribution rate OT - soy isoflavones OT - specific proposed level COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/18 CRDT- 2026/08/27 01:10 PHST- 2026/06/08 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - nu18162696 [pii] AID - nutrients-18-02696 [pii] AID - 10.3390/nu18162696 [doi] PST - epublish SO - Nutrients. 2026 Aug 18;18(16):2696. doi: 10.3390/nu18162696. PMID- 42654273 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 18 TI - Maternal Dietary B-Complex Vitamin Pattern and Risk of Complex Congenital Heart Defects in a Mexican Population. LID - 10.3390/nu18162693 [doi] LID - 2693 AB - BACKGROUND/OBJECTIVES: Congenital heart defects (CHDs) are among the most common congenital anomalies worldwide, and maternal nutrition during early pregnancy may influence their development. Although previous studies have mainly evaluated individual B-complex vitamins, the contribution of their combined dietary intake to CHD risk remains poorly understood. This study investigated the association between maternal dietary B-complex vitamin intake and the risk of complex CHDs in a Mexican case-control study. METHODS: Maternal dietary intake during pregnancy was assessed using a validated food frequency questionnaire, and nutrient intakes were energy-adjusted. Principal component analysis was used to construct a B-Complex Index based on the combined intake of vitamins B1, B2, B3, B6, and B12. Associations were evaluated using multivariable logistic regression adjusted for maternal age, total energy intake, multivitamin supplementation during pregnancy, and periconceptional folic acid supplementation. RESULTS: Mothers of children with complex CHDs had significantly lower dietary intakes of B-complex vitamins than control mothers. The B-Complex Index was independently associated with lower odds of complex CHDs (adjusted OR = 0.707, 95% CI: 0.586-0.843; p = 0.0001). CONCLUSIONS: These findings suggest that evaluating the overall maternal dietary pattern of selected B-complex vitamins may provide complementary information regarding the nutritional environment relevant to early cardiac development. Prospective studies integrating dietary assessment, biomarkers, and genetic susceptibility are warranted to confirm these findings and further elucidate the underlying biological mechanisms. FAU - Vilchis-Gil, Jenny AU - Vilchis-Gil J AUID- ORCID: 0000-0002-5473-6772 AD - Unidad de Investigacion Epidemiologica en Endocrinologia y Nutricion, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. AD - Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico. FAU - Gomez-Jimenez, Aaron M AU - Gomez-Jimenez AM AUID- ORCID: 0009-0003-1099-0431 AD - Departamento de Matematicas, Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico. FAU - Santillan-Orgas, Maria E AU - Santillan-Orgas ME AD - Departamento de Neonatologia, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Segura-Stanford, Begona AU - Segura-Stanford B AD - Departamento de Cardiologia, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Navarro-Castellanos, Inaki AU - Navarro-Castellanos I AUID- ORCID: 0000-0002-7680-0835 AD - Departamento de Cardiologia, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Gomez-Lopez, Jacqueline AU - Gomez-Lopez J AD - Hospital Militar de Especialidades de la Mujer y Neonatologia, Secretaria de la Defensa Nacional, Mexico City 11200, Mexico. FAU - Moran-Espinosa, Mari C AU - Moran-Espinosa MC AD - Laboratorio de Investigacion en Patogenesis Molecular, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Granados-Riveron, Javier T AU - Granados-Riveron JT AD - Laboratorio de Investigacion en Patogenesis Molecular, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Sanchez-Urbina, Rocio AU - Sanchez-Urbina R AUID- ORCID: 0000-0001-8018-7749 AD - Laboratorio de Investigacion en Cardiogenetica, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. AD - Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico City 11340, Mexico. LA - eng GR - HIM/2019/049/Hospital Infantil de Mexico Federico Gomez/ PT - Journal Article DEP - 20260818 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 12001-76-2 (Vitamin B Complex) SB - IM MH - Humans MH - Female MH - *Heart Defects, Congenital/epidemiology/etiology/prevention & control MH - Mexico/epidemiology MH - Pregnancy MH - *Maternal Nutritional Physiological Phenomena MH - Case-Control Studies MH - Adult MH - *Vitamin B Complex/administration & dosage MH - Risk Factors MH - *Diet MH - Dietary Supplements MH - Young Adult PMC - PMC13516518 OTO - NOTNLM OT - B-complex vitamins OT - congenital heart defects OT - maternal nutrition OT - one-carbon metabolism OT - pregnancy OT - principal component analysis COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/18 CRDT- 2026/08/27 01:10 PHST- 2026/06/29 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - nu18162693 [pii] AID - nutrients-18-02693 [pii] AID - 10.3390/nu18162693 [doi] PST - epublish SO - Nutrients. 2026 Aug 18;18(16):2693. doi: 10.3390/nu18162693. PMID- 42654217 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 12 TI - Development and Validation of the Food Consumption Rate Questionnaire (FCRQ): A Behaviorally Informed Measure of Eating-Rate Regulation. LID - 10.3390/nu18162637 [doi] LID - 2637 AB - Background: Eating-rate regulation is a multidimensional behavioral process shaped by oral-processing dynamics, interoceptive cues, sensory engagement, and contextual influences. Despite its relevance, no validated self-report instrument currently assesses these mechanisms. Methods: The Food Consumption Rate Questionnaire (FCRQ) was developed as a behaviorally informed tool for measuring eating-rate regulation. Item generation followed a theory-driven process supported by expert review, forward-backward translation, and pilot testing. Structural validity was examined through Exploratory Factor Analysis (Principal Axis Factoring, Promax rotation) and a theory-driven Confirmatory Factor Analysis evaluating the proposed four-domain model. Reliability was assessed using Cronbach's alpha and corrected item-total correlations. Behavioral heterogeneity was explored using hierarchical and k-means cluster analysis. Results: A clear four-factor structure emerged-Slowness, Awareness of Eating Rate, External Factors, and Awareness & Enjoyment-explaining 42.77% of the variance. CFA indicated acceptable model fit (CFI = 0.93, TLI = 0.91, RMSEA = 0.052), supporting the adequacy of the theoretical structure. Reliability indices were consistent with the multidimensional nature of the construct. All four domains were positively correlated. Cluster analysis identified distinct behavioral profiles, illustrating the instrument's discriminative capacity. Conclusions: The FCRQ provides the first behaviorally informed, psychometrically evaluated framework for assessing eating-rate regulation. The instrument demonstrates a coherent theoretical structure, satisfactory early-stage validity, and the ability to differentiate meaningful behavioral patterns. Continued refinement and validation across diverse populations will further establish the FCRQ as a robust measure for behavioral-nutrition research and practice. FAU - Koliou, Maria P AU - Koliou MP AUID- ORCID: 0009-0009-1751-5629 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. FAU - Karaiskou, Chrysoula AU - Karaiskou C AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Eleftheriadis, Charalampos AU - Eleftheriadis C AUID- ORCID: 0000-0002-0726-4127 AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Skalkos, Dimitris AU - Skalkos D AUID- ORCID: 0000-0002-7771-2845 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. LA - eng PT - Journal Article PT - Validation Study DEP - 20260812 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires/standards MH - Psychometrics MH - Female MH - Factor Analysis, Statistical MH - Male MH - Adult MH - *Eating/psychology MH - Young Adult MH - Adolescent PMC - PMC13516422 OTO - NOTNLM OT - Food Consumption Rate Questionnaire (FCRQ) OT - behavioral nutrition OT - confirmatory factor analysis OT - eating-rate regulation OT - factor analysis OT - interoceptive awareness OT - psychometric evaluation OT - questionnaire development OT - questionnaire validation OT - sensory engagement COIS- C.K. and C.E. were employed by Sidroco Holdings Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/12 CRDT- 2026/08/27 01:09 PHST- 2026/07/25 00:00 [received] PHST- 2026/08/09 00:00 [revised] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:09 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - nu18162637 [pii] AID - nutrients-18-02637 [pii] AID - 10.3390/nu18162637 [doi] PST - epublish SO - Nutrients. 2026 Aug 12;18(16):2637. doi: 10.3390/nu18162637. PMID- 42653984 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 1420-3049 (Electronic) IS - 1420-3049 (Linking) VI - 31 IP - 16 DP - 2026 Aug 20 TI - Exploring the Suitability of High-Performance Thin-Layer Chromatography for the Analysis of Drug Admixtures in Total Parenteral Nutrition Using Caffeine, Ibuprofen and Midazolam as Model Drugs. LID - 10.3390/molecules31162904 [doi] LID - 2904 AB - Total parenteral nutrition (TPN) is a nutritional therapy in children when oral or enteral feeding is not possible, fails to meet nutritional requirements or is contraindicated due to underlying clinical conditions. There are many cases where children who are given one or more than one intravenous medication also need TPN. In order to minimise vein access, these medications are commonly administered via a Y-site IV connection where they admix with TPN, implying a need for compatibility studies before admixing the medication into the nutritional fluid. In this study, previously developed and validated HPTLC methods were verified for their suitability to evaluate the concentrations of three commonly used medications in neonatal intensive care units (NICUs), namely caffeine citrate, ibuprofen arginine, and midazolam hydrochloride. Silica gel 60 F254 HPTLC plates were used as the stationary phase, and acetone: toluene: chloroform (4:3:3, v/v/v), toluene: methanol: ethyl acetate: glacial acetic acid (5.5:3.2:1:0.3, v/v/v/v), and cyclohexane: toluene: diethylamine (7:1.5:1.5, v/v/v) with one drop of 25% ammonia solution were used as mobile phases. The compatibility of the three drugs in their respective TPN admixtures was then assessed at various time points over a 24 h period using these HPTLC methods. Each drug admixed in TPN was directly applied onto the HPTLC plates without further sample pre-treatment. Paired Two-One-Sided Test (TOST) equivalent testing revealed that the concentrations of the selected drugs in TPN were unchanged over the monitoring period (p > 0.05), confirming chemical compatibility. These findings were in line with previous studies that concluded compatibility and reported similar R(F) and LOD/LOQ values (1.95/5.90 ng/band for caffeine, 252.22/764.30 ng/band for ibuprofen and 10.82/32.78 ng/band for midazolam; R(2) >/= 0.99). As no additional sample pre-treatment was required, HPTLC-based compatibility studies of drug-TPN admixtures may simplify the analytical workflow, making them a cost-effective and time-efficient approach to compatibility testing. FAU - Sikdar, K M Yasif Kayes AU - Sikdar KMYK AUID- ORCID: 0000-0003-4958-2745 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. FAU - Islam, Md Khairul AU - Islam MK AUID- ORCID: 0000-0002-9333-6536 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. FAU - Sostaric, Tomislav AU - Sostaric T AUID- ORCID: 0000-0002-0154-4179 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. FAU - Lim, Lee Yong AU - Lim LY AUID- ORCID: 0000-0002-7307-0742 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. AD - Institute for Paediatric Perioperative Excellence, University of Western Australia, Perth, WA 6009, Australia. FAU - Femia, Marcus AU - Femia M AD - Pharmacy Department, Women and Newborn Health Service, King Edward Memorial Hospital, Subiaco, WA 6008, Australia. FAU - Locher, Cornelia AU - Locher C AUID- ORCID: 0000-0001-8773-3036 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. AD - Institute for Paediatric Perioperative Excellence, University of Western Australia, Perth, WA 6009, Australia. LA - eng PT - Journal Article DEP - 20260820 PL - Switzerland TA - Molecules JT - Molecules (Basel, Switzerland) JID - 100964009 RN - 3G6A5W338E (Caffeine) RN - R60L0SM5BC (Midazolam) RN - WK2XYI10QM (Ibuprofen) RN - U26EO4675Q (caffeine citrate) RN - 0 (Citrates) SB - IM MH - *Caffeine/analysis/chemistry MH - Chromatography, Thin Layer/methods MH - *Midazolam/analysis/chemistry MH - *Ibuprofen/analysis/chemistry MH - *Parenteral Nutrition, Total/methods MH - Humans MH - Citrates PMC - PMC13515485 OTO - NOTNLM OT - HPTLC OT - chemical compatibility OT - drug admixing OT - total parenteral nutrition (TPN) COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:09 PHST- 2026/07/28 00:00 [received] PHST- 2026/08/15 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:09 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - molecules31162904 [pii] AID - molecules-31-02904 [pii] AID - 10.3390/molecules31162904 [doi] PST - epublish SO - Molecules. 2026 Aug 20;31(16):2904. doi: 10.3390/molecules31162904. PMID- 42653816 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 1424-8247 (Print) IS - 1424-8247 (Electronic) IS - 1424-8247 (Linking) VI - 19 IP - 8 DP - 2026 Aug 21 TI - Effects of Incretin-Based Therapies on Testosterone Levels and Incretin Response in Men with Hypogonadism: A Systematic Literature Review Following PRISMA 2020 Guidelines. LID - 10.3390/ph19081321 [doi] LID - 1321 AB - Background/Objectives: Male hypogonadism affects 35-50% of men with type 2 diabetes mellitus (T2DM) and obesity. The relationship between testosterone deficiency and response to incretin-based therapies (GLP-1 and GIP receptor agonists) remains incompletely understood. This systematic literature review, conducted following PRISMA 2020 guidelines, examines whether male hypogonadism represents a risk factor for poor response to incretin therapy or, conversely, whether these agents offer therapeutic benefits for this population. Methods: A comprehensive systematic literature search was conducted on 31 December 2024, across PubMed/MEDLINE, Scopus, and Web of Science using three search domains: (1) hypogonadism and incretin therapy response; (2) testosterone deficiency and GLP-1/GIP receptor agonists; (3) incretin response and testosterone. Eligibility criteria included human studies (randomized controlled trials [RCTs], observational studies, cohort studies, cross-sectional studies, systematic reviews, and meta-analyses) in adult men reporting testosterone levels and/or incretin response. Animal studies, pediatric populations, case reports with n < 5, editorials, and letters without data were excluded. Study selection followed PRISMA 2020 guidelines with independent dual screening. Risk of bias was assessed using the Cochrane Risk-of-Bias 2.0 tool (ROB2) for RCTs, the Newcastle-Ottawa Scale (NOS) for observational studies, and AMSTAR-2 for systematic reviews and meta-analyses. Due to substantial heterogeneity in study designs, populations, interventions, and outcome measures, a meta-analysis was not feasible; therefore, a narrative synthesis was performed. Results: From 326 records identified, 29 studies were included after deduplication and screening (primary studies: 14; systematic reviews/meta-analyses: five; narrative reviews/expert opinion: 10). Risk-of-bias assessment revealed moderate-to-high overall risk: RCTs had small sample sizes (n = 12-42) and short follow-up (12-24 weeks), raising concerns about statistical power; observational studies were of fair-to-good quality (NOS 4-7 stars) but subject to confounding; and systematic reviews were of low-to-moderate confidence (AMSTAR-2). Primary evidence from RCTs and observational studies demonstrates that GLP-1 receptor agonists (GLP-1RAs)-particularly semaglutide and liraglutide-and the dual GIP/GLP-1 receptor agonist tirzepatide significantly increase total testosterone levels in men with obesity-related functional hypogonadism (mean increase 2.5-5.2 nmol/L). This effect is largely mediated by weight loss and improvement of insulin resistance rather than direct androgenic action. Evidence regarding whether baseline hypogonadism impairs glycemic or weight-loss response to incretin therapy is limited and indirect; no adequately powered comparative trials stratified by baseline testosterone status were identified. Conclusions: Incretin-based therapies, particularly GLP-1 receptor agonists and the dual GIP/GLP-1 receptor agonist tirzepatide, appear to improve testosterone levels in men with obesity-related functional hypogonadism, an effect that is largely mediated by weight loss and improvement of insulin resistance rather than a direct androgenic action. However, direct comparative evidence between hypogonadal and eugonadal men regarding glycemic or weight-loss response to incretin therapy remains insufficient to draw firm conclusions. The hypothesis that male hypogonadism does not impair incretin therapy response is biologically plausible but is currently supported only by indirect evidence. Prospective, adequately powered trials stratified by baseline testosterone status are needed to resolve this question. FAU - La Vignera, Sandro AU - La Vignera S AUID- ORCID: 0000-0002-7113-2372 AD - Section of Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy. FAU - Condorelli, Rosita AU - Condorelli R AUID- ORCID: 0000-0002-5217-9343 AD - Section of Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123 Catania, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260821 PL - Switzerland TA - Pharmaceuticals (Basel) JT - Pharmaceuticals (Basel, Switzerland) JID - 101238453 PMC - PMC13516258 OTO - NOTNLM OT - GIP receptor agonists OT - GLP-1 receptor agonists OT - PRISMA 2020 OT - functional hypogonadism OT - incretin response OT - liraglutide OT - male hypogonadism OT - obesity OT - semaglutide OT - systematic review OT - testosterone OT - tirzepatide OT - type 2 diabetes mellitus COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/21 CRDT- 2026/08/27 01:09 PHST- 2026/06/18 00:00 [received] PHST- 2026/08/18 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:09 [entrez] PHST- 2026/08/21 00:00 [pmc-release] AID - ph19081321 [pii] AID - pharmaceuticals-19-01321 [pii] AID - 10.3390/ph19081321 [doi] PST - epublish SO - Pharmaceuticals (Basel). 2026 Aug 21;19(8):1321. doi: 10.3390/ph19081321. PMID- 42652740 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 16 DP - 2026 Aug 16 TI - Return to Sport After Surgery for Adolescent Idiopathic Scoliosis: From Time-Based Clearance to Sport-Specific Readiness. LID - 10.3390/jcm15166336 [doi] LID - 6336 AB - Return to sport (RTS) is an important outcome after surgery for adolescent idiopathic scoliosis (AIS), yet postoperative clearance remains largely time-based and reported outcomes vary according to procedure, population, endpoint, and treating-center policy. This critical review integrates direct postoperative RTS cohorts with biomechanical, rehabilitation, psychological, safety, and clinical-guidance evidence. Most available data concern adolescents treated with posterior spinal fusion and rely on self-reported participation. Resumption of physical activity or sport is common within the first postoperative year, but return to the same discipline, previous competitive level, and objectively verified performance is less consistently demonstrated. Evidence for anterior fusion is sparse, whereas vertebral body tethering is supported by smaller, selected cohorts and should be interpreted separately. Associations between RTS and distal fusion level or construct characteristics remain inconsistent, and biomechanical studies suggest redistribution rather than normalization of movement. Reported sport-related complications are uncommon, but existing cohorts are too small and lack exposure denominators to quantify rare events. No universal safe date or validated AIS-specific readiness battery currently exists. The proposed Multidimensional Scoliosis Return-to-Sport Framework therefore uses elapsed time as safety context while integrating clinical recovery, physical and psychological readiness, graded sport-specific exposure, and distinct return outcomes. The framework is evidence-informed and requires prospective validation. FAU - May, Maria Cesarina AU - May MC AD - IRCCS Azienda Ospedaliera Metropolitana, 16132 Genoa, Italy. FAU - Biz, Carlo AU - Biz C AUID- ORCID: 0000-0001-8517-0057 AD - Department of Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padova, 35128 Padova, Italy. FAU - Puce, Luca AU - Puce L AUID- ORCID: 0000-0003-0825-2707 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy. FAU - Zanirato, Andrea AU - Zanirato A AUID- ORCID: 0000-0003-2578-1133 AD - IRCCS Azienda Ospedaliera Metropolitana, 16132 Genoa, Italy. AD - Department of Integrated Surgical Diagnostic Sciences (DISC), Orthopedic Clinic, University of Genoa, 16132 Genoa, Italy. FAU - Ruggieri, Pietro AU - Ruggieri P AUID- ORCID: 0000-0001-9617-9882 AD - Department of Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padova, 35128 Padova, Italy. FAU - Formica, Matteo AU - Formica M AD - IRCCS Azienda Ospedaliera Metropolitana, 16132 Genoa, Italy. AD - Department of Integrated Surgical Diagnostic Sciences (DISC), Orthopedic Clinic, University of Genoa, 16132 Genoa, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260816 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13512920 OTO - NOTNLM OT - adolescent idiopathic scoliosis OT - athletic performance OT - posterior spinal fusion OT - psychological readiness OT - rehabilitation OT - return to sport OT - sports participation OT - vertebral body tethering COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/16 CRDT- 2026/08/27 01:06 PHST- 2026/07/22 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:06 [entrez] PHST- 2026/08/16 00:00 [pmc-release] AID - jcm15166336 [pii] AID - jcm-15-06336 [pii] AID - 10.3390/jcm15166336 [doi] PST - epublish SO - J Clin Med. 2026 Aug 16;15(16):6336. doi: 10.3390/jcm15166336. PMID- 42652559 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 16 DP - 2026 Aug 7 TI - Long-Term Coronary Outcomes and Follow-Up After Kawasaki Disease: Insights from a 25-Year Follow-Up Cohort. LID - 10.3390/jcm15166155 [doi] LID - 6155 AB - Introduction: Kawasaki disease (KD) is an acute systemic vasculitis and the leading cause of acquired pediatric heart disease in high-income countries. Coronary artery aneurysms (CAA) represent the most severe complication and drive long-term cardiovascular risk. Despite improved outcomes with early intravenous immunoglobulin therapy, follow-up strategies remain heterogeneous, particularly for patients showing CAA regression. Dynamic risk stratification based on coronary Z-scores has been proposed, but long-term real-world data are still needed to optimize surveillance. Methods: We conducted a single-center, retrospective study including pediatric patients (age 1 month-18 years) with KD complicated by CAA, followed at Bambino Gesu Children's Hospital (Rome) between 1999 and 2024. Coronary involvement was assessed using Boston Z-scores of the right coronary artery, left main coronary artery, and left anterior descending artery. CAA severity over time was analyzed using a composite MAX SCORE (highest Z-score among coronary branches) along with the 1-YEAR MAX SCORE (highest MAX SCORE reached within the 1 year of disease). The distribution and timing of cardiac computed tomography angiography (CCTA) and exercise stress testing (EST) during follow-up were analyzed in relation to coronary severity. Results: Among 502 KD patients, 122 (24.3%) developed CAA; 113 were included in the analysis. Mean age at diagnosis was 24.6 months (M/F 3.5:1). Multivessel involvement was observed in 72%, most frequently affecting the left anterior descending artery. Long-term follow-up >/=10 years was available for 31.9% of patients. Most changes in coronary severity occurred within the first year after disease onset, with complete CAA regression in 76.1% of patients. Conversely, 53% of patients affected by giant aneurysms at 12 months showed persistent severe disease at last follow-up. EST (164 tests in 40 patients) was almost universally negative for inducible ischemia (163/164), whereas CCTA (47 exams in 35 patients) was preferentially performed early and in higher-risk patients. Test prescription correlated more closely with 1-YEAR MAX SCORE than with contemporaneous severity. Echocardiography showed systematic differences compared with CCTA for right coronary and left anterior descending artery Z-scores. Discussion: In our experience, early coronary status was closely associated with the intensity of long-term surveillance strategies in KD. The 1-YEAR MAX SCORE was associated with subsequent patterns of coronary evolution, and the continuous 1-year Maximum Z-score showed good discriminatory ability for persistent CAA on ROC analysis, pending external validation. While the low rate of positive findings on EST raises questions about its diagnostic yield in real-world practice, CCTA provided detailed anatomical characterization. Overall, these findings suggest that early coronary severity may help inform individualized, severity-driven follow-up strategies, warranting confirmation in prospective multicenter studies. FAU - Musolino, Antonio AU - Musolino A AUID- ORCID: 0000-0002-3316-957X AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Marchesi, Alessandra AU - Marchesi A AUID- ORCID: 0000-0002-6802-934X AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Antonelli, Giovanni AU - Antonelli G AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Gargiullo, Livia AU - Gargiullo L AUID- ORCID: 0000-0003-0316-6359 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Storelli, Flavio AU - Storelli F AD - Meyer Children's Hospital IRCCS, 50139 Florence, Italy. FAU - Orso, Giovanni AU - Orso G AD - Pediatric Emergency Department, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Benelli, Benedetta AU - Benelli B AD - School of Pediatrics, Tor Vergata University of Rome, 00133 Roma, Italy. FAU - Ventura, Marta AU - Ventura M AD - School of Pediatrics, Tor Vergata University of Rome, 00133 Roma, Italy. FAU - Ariaudo, Ludovica AU - Ariaudo L AD - Department of Sciences of Public Health and Pediatrics, University of Turin, 10124 Torino, Italy. FAU - Cafiero, Giulia AU - Cafiero G AUID- ORCID: 0000-0001-6180-9338 AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Calcagni, Giulio AU - Calcagni G AUID- ORCID: 0000-0003-3187-0829 AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Leonardi, Benedetta AU - Leonardi B AUID- ORCID: 0000-0001-6715-3472 AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Lioncino, Michele AU - Lioncino M AUID- ORCID: 0000-0003-0205-5235 AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Secinaro, Aurelio AU - Secinaro A AUID- ORCID: 0000-0002-2611-8061 AD - Advanced Cardiothoracic Imaging Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Babini, Riccardo AU - Babini R AUID- ORCID: 0000-0001-7896-8191 AD - Independent Data Analyst and Software Engineer, Via Armando Diaz 10, 20881 Bernareggio, Italy. FAU - Villani, Alberto AU - Villani A AUID- ORCID: 0000-0002-9120-0424 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. LA - eng PT - Journal Article DEP - 20260807 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13513250 OTO - NOTNLM OT - Kawasaki disease OT - cardiac imaging OT - cardiac tomography OT - coronary Z-score OT - coronary artery aneurysms OT - exercise stress testing OT - long-term follow-up OT - pediatric cardiology COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/07 CRDT- 2026/08/27 01:06 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:06 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - jcm15166155 [pii] AID - jcm-15-06155 [pii] AID - 10.3390/jcm15166155 [doi] PST - epublish SO - J Clin Med. 2026 Aug 7;15(16):6155. doi: 10.3390/jcm15166155. PMID- 42652543 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 16 DP - 2026 Aug 7 TI - Psychiatric and Psychosocial Outcomes of Bariatric Surgery in Adolescents and Adult Women: A Prospective Cohort Study. LID - 10.3390/jcm15166139 [doi] LID - 6139 AB - Background/Objectives: The rising prevalence of severe adolescent obesity has increased the number of young patients referred for bariatric surgery. The psychiatric and psychosocial profiles of adolescents and of adult women undergoing this treatment remain insufficiently characterized. This study compared preoperative and postoperative psychiatric, psychosocial, and metabolic profiles of adolescents and adult women undergoing bariatric surgery. Methods: This prospective cohort study recruited 77 consecutive female patients (32 adolescents aged <18 years; 45 adult women aged 18-25 years) at a single bariatric center in Poland between December 2022 and December 2023. All participants underwent comprehensive preoperative and one-year postoperative assessments including laboratory testing, standardized psychiatric interviews, and psychometric screening with the Beck Depression Inventory (BDI) and the Patient Health Questionnaire-9 (PHQ-9). Results: Preoperatively, adolescents were more severely affected for their age (median BMI-for-age z-score 3.53) and waited longer between the first obesity clinic visit and surgery. Adolescents more frequently reported self-harm behaviors and moderate-to-severe depression on the BDI, whereas adult women more often reported psychoactive substance use. Both groups achieved comparable improvements in laboratory and comorbidity outcomes at one year, although relative weight loss was greater in adult women (median total weight loss 37.6% vs. 28.4%, p < 0.0001). Postoperatively, a greater proportion of adolescents than adult women improved with respect to social anxiety (50.0% vs. 13.3%, p = 0.0007) and BDI depression severity (53.1% vs. 24.4%, p = 0.02), whereas a greater proportion of adult women improved with respect to psychoactive substance use (46.7% vs. 12.5%, p = 0.003). Generalized anxiety and suicidal ideation declined within both groups, but the extent of improvement did not differ significantly between them. These differences persisted, and for several outcomes became larger, after adjustment for the reduction in BMI, which was smaller in adolescents. Conclusions: In this observational cohort, bariatric surgery was associated with distinct psychiatric and psychosocial outcome profiles in adolescents compared with adult women. Because the study was uncontrolled and included no non-surgical comparison group, these findings are hypothesis-generating and cannot establish a causal effect of surgery or of its timing; confirmation in larger, multicenter studies with appropriate comparison groups is required. Comprehensive multidisciplinary perioperative care and tailored postoperative psychological support appear important for both age groups. FAU - Herstowska, Marta AU - Herstowska M AUID- ORCID: 0000-0002-0905-6233 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Przygocka-Pieniazek, Ada AU - Przygocka-Pieniazek A AUID- ORCID: 0000-0001-7831-0242 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Lejk, Agnieszka AU - Lejk A AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Burzynski, Jacek AU - Burzynski J AD - Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland. FAU - Mysliwiec, Malgorzata AU - Mysliwiec M AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Kaska, Lukasz AU - Kaska L AD - Hospital of the Ministry of the Interior and Administration, 80-104 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260807 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13513403 OTO - NOTNLM OT - adolescent obesity OT - bariatric surgery OT - depression OT - mental health OT - psychosocial outcomes COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/07 CRDT- 2026/08/27 01:06 PHST- 2026/06/25 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:06 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - jcm15166139 [pii] AID - jcm-15-06139 [pii] AID - 10.3390/jcm15166139 [doi] PST - epublish SO - J Clin Med. 2026 Aug 7;15(16):6139. doi: 10.3390/jcm15166139. PMID- 42652044 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 14 IP - 8 DP - 2026 Jul 24 TI - Early-Life Biomarkers in Food Allergy Development: A Systematic Review of Immunological and Intestinal Pathways. LID - 10.3390/biomedicines14081661 [doi] LID - 1661 AB - Background: The increasing incidence of pediatric food allergy (FA) drives an imperative for mechanistically driven risk stratification beyond descriptive diagnostics. The current systematic review aims to assess the predictive and diagnostic value of early-life non-invasive biomarkers: cord blood IgE (CS-IgE), fecal calprotectin (FC), fecal zonulin (FZ) and secretory IgA (SIgA). Methods: In accordance with the PRISMA guidelines, we performed a systematic literature search on PubMed/MEDLINE and Scopus for English observational studies published in 2009-2025. The titles and abstracts were screened by two independent reviewers and methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). Results: A total of 17 studies met the inclusion criteria. This synthesis demonstrates that CS-IgE reflects a systemic atopic predisposition rather than serving as a highly sensitive predictor for isolated FA. Fecal calprotectin was the most consistent marker of inflammatory activity in non-IgE-mediated food allergies, with median values in food allergy ranging from approximately 200 to 410 microg/g and proven useful in dietary monitoring. Fecal zonulin reflects epithelial barrier dysfunction; however, its clinical utility is limited by suboptimal assay specificity. SIgA primarily reflects mucosal immune maturation and tolerance development rather than serving as a direct diagnostic marker. Conclusions: Although CS-IgE, FC, FZ and SIgA exhibit potential in the risk stratification of early FA, their clinical implementation is complicated by methodological heterogeneity and concerns regarding analytical specificity, especially with respect to zonulin assays. We propose an integrated multi-biomarker risk stratification model as a conceptual hypothesis requiring prospective validation in future large-scale studies. FAU - Ivasko, Alina-Maria AU - Ivasko AM AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. AD - Department of Internal Medicine, Emergency Clinical County Hospital of Targu Mures, Gheorghe Marinescu Street 50, 540136 Targu Mures, Mures, Romania. FAU - Ureche, Corina AU - Ureche C AUID- ORCID: 0000-0002-1235-9331 AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. FAU - Marginean, Oana Cristina AU - Marginean OC AUID- ORCID: 0000-0003-2119-1726 AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. FAU - Grama, Monica AU - Grama M AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. FAU - Nicola-Varo, Teodora AU - Nicola-Varo T AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260724 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC13509919 OTO - NOTNLM OT - cord blood IgE OT - fecal calprotectin OT - fecal zonulin OT - food allergy OT - predictive biomarkers OT - secretory IgA COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/07/24 CRDT- 2026/08/27 01:05 PHST- 2026/05/24 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:05 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - biomedicines14081661 [pii] AID - biomedicines-14-01661 [pii] AID - 10.3390/biomedicines14081661 [doi] PST - epublish SO - Biomedicines. 2026 Jul 24;14(8):1661. doi: 10.3390/biomedicines14081661. PMID- 42651535 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 7 TI - The Association Between Physical Activity and Physical Literacy Among Adolescents: A Cross-Sectional Study. LID - 10.3390/bs16081358 [doi] LID - 1358 AB - This study examined the association between physical activity (PA) patterns and physical literacy (PL) among adolescents in Shanghai, China. The researchers conducted a cross-sectional survey between December 2021 and February 2022. They recruited 1624 adolescents aged 11 to 18 from schools in various districts of Shanghai using stratified sampling. Out of these, 1500 provided complete and valid questionnaires for analysis. The researchers assessed PL using a validated adolescent Physical Literacy Questionnaire and measured PA with an updated PA questionnaire that included school-based, household, transportation, and leisure activities. The demographic factors considered included gender, school stage, academic performance, and family socioeconomic status (SES). Two-way multivariate analysis of variance (MANOVA) and multiple linear regression analyses were used to explore group differences and the connections between PA and PL. The MANOVA results showed significant differences in PA based on gender (F(1,1498) = 7.94, p < 0.001) and school stage (F(1,1498) = 9.79, p < 0.001). However, no significant differences were found concerning academic performance (F(1,1498) = 2.12, p = 0.081) or SES (F(1,1498) = 1.90, p = 0.072). On the other hand, PL varied significantly by school stage (F(1,1498) = 9.55, p < 0.001), academic performance (F(1,1498) = 8.84, p < 0.05), and SES (F(1,1498) = 7.94, p < 0.05), but not by gender (F(1,1498) = 1.90, p = 0.121). Furthermore, multiple regression analyses revealed that involvement in school-based, transportation, and leisure-time PA was positively associated with adolescents' PL, whereas household PA was not. These findings suggest that adolescents' participation in PA and their PL vary among different demographic groups. Additionally, different PA contexts are associated with varying degrees of PL development. Because of the cross-sectional nature of the study, these findings should be seen as associative rather than indicating a causal relationship. Programs that encourage participation in school-based, transportation, and leisure activities may help improve adolescents' physical literacy. FAU - Qian, Song AU - Qian S AD - School of Marxism, Shanghai University of Sport, No. 399, Changhai Road, Yangpu District, Shanghai 200438, China. FAU - Wang, Xuebin AU - Wang X AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China. AD - Post-Doctoral Station of Sport Science, Fujian Normal University, Cangshan Campus, No. 8 Shangsan Road, Cangshan District, Fuzhou 350007, China. FAU - Dan, He AU - Dan H AD - School of Journalism and Communication, Shanghai University of Sport, No. 399, Changhai Road, Yangpu District, Shanghai 200438, China. FAU - Qin, Yuke AU - Qin Y AD - School of Education, City University of Macau, Avenida Padre Tomas Pereira, Taipa, Macau 999078, China. LA - eng GR - 22CTY011/National Social Science Fund Youth Projects/ GR - 2020ETY004/Shanghai Social Science Planning Youth Project/ GR - C2-2020012/Shanghai Education Science Research Projects/ PT - Journal Article DEP - 20260807 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13509980 OTO - NOTNLM OT - adolescents OT - household PA OT - moderate-to-vigorous PA OT - physical activity OT - physical literacy OT - school-based PA COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/07 CRDT- 2026/08/27 01:04 PHST- 2026/04/20 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/25 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - bs16081358 [pii] AID - behavsci-16-01358 [pii] AID - 10.3390/bs16081358 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 7;16(8):1358. doi: 10.3390/bs16081358. PMID- 42651521 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 5 TI - An Active Approach to Behavior: Exergaming Bike Breaks for Students with Disabilities. LID - 10.3390/bs16081344 [doi] LID - 1344 AB - Many children, particularly those with disabilities, do not meet the recommended amount of physical activity per day, which can increase the likelihood of poor health outcomes. Beyond the potential health benefits, physical activity breaks are associated with increased academic engagement and decreased stereotypy and off-task behavior. It is important to increase periods of physical activity in naturalistic settings like schools. The purpose of this article is to describe two pilot studies that examined the feasibility of integrating exergaming bike breaks into daily school routines for students with disabilities. Across the studies, data were collected on physical fitness, mood, classroom behavior, and acceptability. In Study 1, 13 students ages 9-13 with autism participated in exergaming biking for 15 min, 3 days per week for 6 weeks. No significant differences were observed between ride and non-ride days for teacher-reported behaviors; however, researcher-observed disruptive behaviors were significantly lower on ride days. In Study 2, six students with disabilities ages 9-17 who had a behavior intervention plan participated in biking for 5 days per week for 10 weeks. There was a significant increase in the percentage of time students were on-task and a decrease in time students were reported to be disruptive based on teacher behavior reports. Physical fitness remained low following intervention. Overall, exergaming biking was an acceptable and engaging form of physical activity that can be integrated into students' daily routines. Use of the bikes was associated with some improvement in classroom behavior. We discuss implications for practice and recommendations for future research. FAU - Kupzyk, Sara AU - Kupzyk S AUID- ORCID: 0000-0002-6721-8659 AD - Department of Psychology, University of Nebraska at Omaha, Omaha, NE 68182, USA. FAU - Reelfs, Heidi K AU - Reelfs HK AD - Department of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68106, USA. FAU - Kupzyk, Kevin AU - Kupzyk K AD - College of Nursing, University of Nebraska Medical Center, Omaha, NE 68198, USA. LA - eng GR - 2017/Munroe-Meyer Institute Guild Grant/ PT - Journal Article DEP - 20260805 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13509195 OTO - NOTNLM OT - exergaming OT - physical activity breaks OT - positive behavior intervention COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/05 CRDT- 2026/08/27 01:04 PHST- 2026/05/21 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - bs16081344 [pii] AID - behavsci-16-01344 [pii] AID - 10.3390/bs16081344 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 5;16(8):1344. doi: 10.3390/bs16081344. PMID- 42651518 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 4 TI - Beyond Screen Time: Parent-Adolescent Relationship as a Mediating Pathway Between Problematic Internet Use and Psychological Well-Being Among Malaysian Adolescents. LID - 10.3390/bs16081341 [doi] LID - 1341 AB - The construct of adolescent psychological well-being has long been a focus of both public discourse and scholarly inquiry. With the widespread adoption of the Internet, there have been growing concerns about adolescents' exposure to escalating online risks. Parental mediation has been hypothesised to facilitate the guidance and regulation of adolescents' Internet use. However, the specific mediating role of the parent-adolescent relationship in the association between problematic Internet use and psychological well-being has remained underexamined, a gap explored in the current study. Based on the theoretical underpinnings provided by Phase Three of Bronfenbrenner's Bioecological Model of Human Development, a cross-sectional survey using validated psychometric instruments was conducted, involving 1598 students (mean age 16.0 years; 51% female) from secondary schools in Selangor, Malaysia. For data analysis, inferential statistics and partial least squares-structural equation modelling (PLS-SEM) were used to examine the complex structural relationships among the variables. Mean scores for problematic Internet use and psychological well-being indicated moderate severity levels. SEM results indicated the negative influence of problematic Internet use on psychological well-being (beta = -0.104 *, p = 0.040) and parent-adolescent relationship (beta = -0.241 **, p < 0.001) and a significant positive influence of parent-adolescent relationship on psychological well-being (beta = 0.328 **, p < 0.001). Subsequent mediation analysis confirmed the partial mediating effect of parent-adolescent relationship (indirect association: beta = -0.079) on the relationship between problematic Internet use and psychological well-being among Malaysian adolescents. This was consistent with Bronfenbrenner's Bioecological Model of Human Development. Strengthening the parent-adolescent relationship could mitigate the adverse psychological effects of excessive Internet use. From a policy perspective, these findings supported the use of family-focused intervention as a strategy to address the adverse psychological effects of problematic Internet use among adolescents. FAU - Okafor-Emeagha, Ijeoma Miriam AU - Okafor-Emeagha IM AUID- ORCID: 0000-0003-2561-6680 AD - Faculty of Nursing Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia. FAU - Ramoo, Vimala AU - Ramoo V AUID- ORCID: 0000-0001-8506-7826 AD - School of Nursing, Faculty of Health Sciences, Nursing and Education, Mahsa University, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia. FAU - Marret, Mary Joseph AU - Marret MJ AUID- ORCID: 0000-0002-1739-8751 AD - Department of Pediatrics, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia. FAU - Ling, Lee Wan AU - Ling LW AUID- ORCID: 0000-0002-5584-2905 AD - Faculty of Nursing Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13510131 OTO - NOTNLM OT - adolescence OT - parental mediation OT - problematic internet use OT - psychological well-being COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/04 CRDT- 2026/08/27 01:04 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - bs16081341 [pii] AID - behavsci-16-01341 [pii] AID - 10.3390/bs16081341 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 4;16(8):1341. doi: 10.3390/bs16081341. PMID- 42651483 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 1 TI - Developing and Evaluating a Universal Primary School Body Image Program: An Uncontrolled Pilot Study of Butterfly Body Bright. LID - 10.3390/bs16081306 [doi] LID - 1306 AB - Body image develops during childhood, yet few universal programs address body dissatisfaction and disordered eating risk across the primary school years. This paper describes the development of Butterfly Body Bright, which is, to our knowledge, a world-first whole-of-school program promoting positive body image and healthy relationships with eating and physical activity across all primary school years. We also describe an uncontrolled pilot study that evaluated the feasibility, acceptability, and impact of components of the program, namely, online staff training and teacher-led lessons from three program themes. Lessons targeted appearance-based teasing, media literacy, body gratitude, and self-compassion. Participants were 12 teachers and 114 Grade 4 to 6 children in Australia, who received one of seven Body Bright lessons. Significant pre- to immediate post-program improvements emerged in state body satisfaction, body appreciation, confidence managing appearance-based teasing, and help-seeking intentions. Specific lessons improved media literacy and appearance comparison and, at a 3-to-7-week follow-up, trait body appreciation. Boys showed improvement in state body satisfaction, confidence managing appearance-based teasing, and appreciation of body functionality. Girls showed improvement in state body satisfaction and media literacy. Butterfly Body Bright showed some promising preliminary results, with small to large effects, and was deemed feasible and acceptable by teachers, supporting the need for a randomized controlled trial. FAU - Damiano, Stephanie R AU - Damiano SR AUID- ORCID: 0000-0001-7659-4413 AD - School of Psychology and Public Health, La Trobe University, Melbourne 3086, Australia. AD - Butterfly Foundation, Sydney 2065, Australia. FAU - Jarman, Hannah K AU - Jarman HK AUID- ORCID: 0000-0001-8225-4511 AD - School of Psychology, Deakin University, Geelong 3220, Australia. FAU - Paxton, Susan J AU - Paxton SJ AUID- ORCID: 0000-0002-8486-1996 AD - School of Psychology and Public Health, La Trobe University, Melbourne 3086, Australia. LA - eng GR - NA/FDC Construction & Fitout/ PT - Journal Article DEP - 20260801 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13509812 OTO - NOTNLM OT - body dissatisfaction OT - body image OT - children OT - prevention OT - school OT - teachers OT - universal COIS- The first author (SRD) serves as the Manager of Butterfly Body Bright at Butterfly Foundation, the organisation responsible for delivering the program evaluated in this study. The authors recognize this represents a competing interest and declare it accordingly. However, all authors affirm that this relationship has not influenced the collection, analysis, or interpretation of data, nor the presentation of results. To mitigate potential bias, data entry and statistical analyses were conducted independently by a university-based co-author (HKJ). All authors agree with the contents of this manuscript. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/01 CRDT- 2026/08/27 01:04 PHST- 2026/05/22 00:00 [received] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - bs16081306 [pii] AID - behavsci-16-01306 [pii] AID - 10.3390/bs16081306 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 1;16(8):1306. doi: 10.3390/bs16081306. PMID- 42650945 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 16 DP - 2026 Aug 12 TI - Association of Inflammatory and Nutritional Biomarkers in Children with Febrile Seizures: A Case-Control Study of NLR, PNI, and CAR. LID - 10.3390/diagnostics16162541 [doi] LID - 2541 AB - Background/Objectives: Febrile seizures (FS) are the most frequent seizure disorder in childhood. Growing evidence suggests that systemic inflammatory responses may contribute to FS pathogenesis. Easily accessible inflammatory markers derived from routine blood tests, including the neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and C-reactive protein-to-albumin ratio (CAR), have been investigated as potential indicators of inflammatory status. This study aimed to explore the association between these biomarkers and FS in children. Methods: The medical records of 401 children were retrospectively evaluated, including 200 patients diagnosed with FS and 201 age-matched controls without a history of seizures. Demographic data and laboratory parameters were obtained, and NLR, PNI, and CAR were calculated. Group comparisons were performed using appropriate statistical tests. Multivariable logistic regression was applied to determine independent factors associated with FS, and receiver operating characteristic (ROC) analysis was conducted to evaluate biomarker performance. Results: Compared with controls, children with FS had higher neutrophil counts, NLR, and CAR values, whereas lymphocyte counts and PNI values were lower (all p < 0.05). Male sex was more frequent in the FS group (62.5% vs. 47.8%, p = 0.004). In multivariable analysis, younger age, male sex, and increased NLR were independently associated with FS. However, CAR and PNI did not remain significant after adjustment. NLR showed the highest discriminative ability among the evaluated markers, although its diagnostic performance was limited (AUC = 0.647). Conclusions: NLR may reflect the inflammatory response associated with febrile seizures and could provide supportive clinical information. However, its moderate diagnostic accuracy prevents its use as a standalone diagnostic marker. Further studies are required to clarify its clinical utility. FAU - Perk, Peren AU - Perk P AD - Department of Pediatric Neurology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Gumus Sarac, Suheyla AU - Gumus Sarac S AD - Department of Pediatric Emergency, Bursa Dortcelik Children Hospital, Bursa 16120, Turkey. FAU - Sandikkaya, Ayse AU - Sandikkaya A AD - Department of Pediatric Neurology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Ekici Ibrahimoglu, Fulya Sibel AU - Ekici Ibrahimoglu FS AD - Department of Pediatric Neurology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Karadogan, Muhammed Talha AU - Karadogan MT AD - Department of Pediatric Rheumatology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Koc, Rahime AU - Koc R AUID- ORCID: 0000-0002-9927-1526 AD - Department of Pediatric Rheumatology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Havali, Cengiz AU - Havali C AUID- ORCID: 0000-0001-6275-0884 AD - Department of Pediatric Neurology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. LA - eng PT - Journal Article DEP - 20260812 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13511628 OTO - NOTNLM OT - C-reactive protein-to-albumin ratio OT - febrile seizure OT - neutrophil-to-lymphocyte ratio OT - prognostic nutritional index COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/12 CRDT- 2026/08/27 01:03 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:03 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - diagnostics16162541 [pii] AID - diagnostics-16-02541 [pii] AID - 10.3390/diagnostics16162541 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Aug 12;16(16):2541. doi: 10.3390/diagnostics16162541. PMID- 42650934 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 16 DP - 2026 Aug 11 TI - Applying Artificial Intelligence to Childhood Obesity: T2DM and MASLD Risk Predictive Models. LID - 10.3390/diagnostics16162533 [doi] LID - 2533 AB - Pediatric obesity is a complex, multifactorial pandemic with serious early-onset comorbidities, including prediabetes, type 2 diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular disorders. While lifestyle modifications and the Mediterranean diet remain primary interventions, artificial intelligence (AI) is emerging as a critical tool for early diagnosis and personalized management. This review evaluates the current role of AI in predicting and treating childhood obesity and its complications. A literature search was conducted on PubMed and Google Scholar for English-language articles published from 2015 onward. Search terms included combinations of keywords related to "obesity", "pediatric", "comorbidities" (e.g., MASLD, diabetes), and "artificial intelligence" (e.g., machine learning, deep learning, multi-omics). Eligible study types ranged from original articles to systematic reviews and clinical guidelines. By integrating multi-omic data (genome, epigenome, transcriptome, metabolome, microbiota) with socio-psychological metrics, AI can predict obesity risk and early complications. Machine learning (ML) and deep learning have successfully identified specific metabolites, gut flora alterations, neurological pathways, and metabolic SNPs linked to obesity susceptibility. Furthermore, ML-driven prognostic models enable risk assessment for MASLD or diabetes progression, while specialized software supports remote lifestyle monitoring and tailored dietary interventions. AI has the potential to revolutionize pediatric obesity management through precision medicine. However, challenges regarding data privacy, digital literacy, and equitable access persist. Because current evidence relies heavily on limited and heterogeneous pediatric datasets, large-scale, well-characterized, and externally validated cohorts are essential to establish the clinical applicability of AI models before routine implementation. FAU - Amitrano, Marianna AU - Amitrano M AD - Unit of Pediatrics and Neonatology, Hospital "San Giovanni di Dio", 80027 Frattamaggiore, Italy. FAU - Mondillo, Gianluca AU - Mondillo G AUID- ORCID: 0009-0000-7756-8145 AD - Department of Woman, Child and of General and Specialized Surgery, Universita Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy. FAU - Emiliano, Mario AU - Emiliano M AD - Unit of Pediatrics and Neonatology, Hospital "San Giovanni di Dio", 80027 Frattamaggiore, Italy. FAU - Santoro, Umberto Paolo AU - Santoro UP AD - Department of Public Health, University of Naples "Federico II", 80131 Naples, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260811 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13511550 OTO - NOTNLM OT - MASLD OT - artificial intelligence OT - childhood obesity OT - type 2 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/11 CRDT- 2026/08/27 01:03 PHST- 2026/05/19 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:03 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - diagnostics16162533 [pii] AID - diagnostics-16-02533 [pii] AID - 10.3390/diagnostics16162533 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Aug 11;16(16):2533. doi: 10.3390/diagnostics16162533. PMID- 42650550 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 16 DP - 2026 Aug 16 TI - Occurrence of Pesticide Residues and Acute, Chronic, and Cumulative Dietary Risk Assessment in Mango (Mangifera indica L.) from Lower Northern Thailand. LID - 10.3390/foods15162856 [doi] LID - 2856 AB - Mango (Mangifera indica L.), particularly the 'Nam Dok Mai' cultivar, is an economically important fruit crop in Thailand and is widely produced in the Lower Northern Region for domestic consumption and export. However, pesticide residues in mango remain a major food safety concern because of their potential effects on consumer health and compliance with national and international maximum residue limits (MRLs). This study investigated pesticide residue contamination and assessed the dietary health risks associated with mango consumption among different age groups. A total of 255 composite mango samples were collected from production areas in Phichit, Phitsanulok, and Phetchabun provinces, Thailand. Pesticide residues were analyzed using a validated modified QuEChERS extraction method combined with gas chromatography-tandem mass spectrometry (GC-MS/MS). Multiple pesticide residues were frequently detected in the samples analyzed. Of the detected residues, 22 pesticides exceeded Thai MRL standards and 14 exceeded Codex Alimentarius MRLs. Dietary exposure was evaluated using acute and chronic hazard quotients (HQa and HQc) and cumulative hazard indices (HIa and HIc). The results showed that acute exposure to several insecticides, particularly carbofuran, lambda-cyhalothrin, and fenpropathrin, exceeded acceptable risk thresholds in all age groups. At the pesticide-class level, cumulative acute exposure to organophosphates, carbamates, and pyrethroids showed HIa values greater than 1 in several age groups, suggesting potential short-term health concerns, especially among children. In contrast, chronic exposure to individual pesticides and cumulative pesticide groups remained below the level of concern for all age groups, with HQc and HIc values below 1. These findings indicate that although long-term dietary risk from mango consumption is within acceptable levels, acute exposure to certain pesticide residues may pose non-negligible health risks. Continuous residue monitoring, stricter enforcement of good agricultural practices, and evidence-based risk management are essential to ensure mango safety and protect consumers. FAU - Boonthawee, Kanlayanee AU - Boonthawee K AUID- ORCID: 0009-0008-0144-8196 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Tongchai, Phannika AU - Tongchai P AUID- ORCID: 0000-0002-4045-6534 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Yana, Pichamon AU - Yana P AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Jaitham, Udomsap AU - Jaitham U AUID- ORCID: 0009-0006-2554-7127 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Jeeno, Peerapong AU - Jeeno P AUID- ORCID: 0000-0002-3757-8557 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Lungmala, Nid AU - Lungmala N AUID- ORCID: 0009-0008-8947-1162 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Yadoung, Sumed AU - Yadoung S AUID- ORCID: 0009-0000-5798-0132 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Danmek, Khanchai AU - Danmek K AUID- ORCID: 0000-0002-2348-463X AD - School of Agriculture and Natural Resources, University of Phayao, Phayao 56000, Thailand. FAU - Treewannakul, Panamas AU - Treewannakul P AUID- ORCID: 0000-0002-1815-9349 AD - Faculty of Agriculture, Kasetsart University, Bangkok 20900, Thailand. FAU - Amekawa, Yuichiro AU - Amekawa Y AUID- ORCID: 0000-0003-0596-5242 AD - College of International Relations, Ritsumeikan University, Kyoto 603-8577, Japan. FAU - Hongsibsong, Surat AU - Hongsibsong S AUID- ORCID: 0000-0002-5510-5905 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. LA - eng GR - 036/2568/Research Institute for Health Sciences/ GR - 2275/2568/Thailand Science Research and Innovation Fund/ GR - 23K27014/Japan Society for the Promotion of Science (JSPS) KAKENHI/ PT - Journal Article DEP - 20260816 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13512399 OTO - NOTNLM OT - GC-MS/MS OT - QuEChERS OT - dietary risk assessment OT - hazard index OT - mango OT - pesticide residues COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/16 CRDT- 2026/08/27 01:02 PHST- 2026/07/13 00:00 [received] PHST- 2026/08/09 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/16 00:00 [pmc-release] AID - foods15162856 [pii] AID - foods-15-02856 [pii] AID - 10.3390/foods15162856 [doi] PST - epublish SO - Foods. 2026 Aug 16;15(16):2856. doi: 10.3390/foods15162856. PMID- 42650538 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 16 DP - 2026 Aug 14 TI - Traceability and Health Risk Assessment in the Feed-Animal-Milk Chain: A Comparative Evaluation of Traditional and Industrial Dairy Systems in Romania. LID - 10.3390/foods15162844 [doi] LID - 2844 AB - Cow milk and dairy products may reflect environmental elemental inputs transferred through the feed-animal-milk chain. This study investigated the elemental traceability, regional differentiation, dairy processing effects, and dietary exposure associated with milk and dairy products from two contrasting Romanian dairy production systems: the traditional Vaideeni region and the industrial Ibanesti region. A total of 88 samples (water, feed, raw milk, and dairy products) were seasonally collected during 2024-2025 and analysed for trace elements, geochemical fingerprint elements, and macroelements using ICP-OES and atomic absorption spectrometry. The strongest regional elemental contrasts were observed in groundwater for V (Deltalog(10) = +1.30), U (+0.82), Sr (+0.61), and Mn (+0.60), but these differences were substantially attenuated during biological transfer. Nevertheless, Li, U, Sr, Mn, and Cu retained measurable regional differences in milk. Regional elemental contrasts within the feed indicated an important inverse relationship (Pearson r = -0.60, p = 0.018), whereas no significant correlation was found between water and milk (Pearson r = -0.19, p = 0.493), suggesting that the milk elemental patterns may be influenced by biological regulatory processes in addition to the environmental signatures. Dairy processing further modified the elemental distribution, with the trace elements showing increased redistribution compared to the macroelements, while the geochemical fingerprint elements preserved regional information. The dietary exposure estimates for Cd and Ni remained below the corresponding toxicological reference values, whereas the highest estimated Pb exposure from hard cheese reached 0.977 mug/kg body weight/day for children and 0.558 mug/kg body weight/day for adults, exceeding the EFSA BMDL(01) reference point. The results indicate that multielement fingerprinting may provide promising information for investigating elemental traceability and supporting dairy product authenticity assessment within the investigated production systems, although extensive geographical validation will be required before application as a general authentication tool. FAU - Zgavarogea, Ionela Ramona AU - Zgavarogea IR AUID- ORCID: 0000-0001-7997-0090 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. FAU - Paun, Nadia AU - Paun N AUID- ORCID: 0000-0002-9702-1494 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. FAU - Sandru, Claudia AU - Sandru C AUID- ORCID: 0000-0002-5168-7290 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. FAU - Niculescu, Violeta-Carolina AU - Niculescu VC AUID- ORCID: 0000-0002-0439-3265 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. FAU - Nasture, Ana Maria AU - Nasture AM AUID- ORCID: 0000-0003-0298-5774 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. AD - DAIC SYSTEM S.R.L., 58 Fantanii Street, 240301 Ramnicu Valcea, Romania. FAU - Miricioiu, Marius-Gheorghe AU - Miricioiu MG AUID- ORCID: 0000-0002-0080-6595 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. LA - eng GR - NUCLEU Program-Financing Contract no. 20N/05.01.2023, Project PN 23 15 03 01/Romanian Ministry of Education and Research/ GR - NUCLEU Program-Financing Contract no. 20N/05.01.2023, Project PN 23 15 03 02/Romanian Ministry of Education and Research/ PT - Journal Article DEP - 20260814 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13512816 OTO - NOTNLM OT - ICP-OES OT - dairy processing OT - environmental exposure OT - food authenticity OT - geochemical fingerprinting OT - regional traceability COIS- Author Ana Maria Nasture was employed by the company DAIC SYSTEM S.R.L. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/14 CRDT- 2026/08/27 01:02 PHST- 2026/06/23 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - foods15162844 [pii] AID - foods-15-02844 [pii] AID - 10.3390/foods15162844 [doi] PST - epublish SO - Foods. 2026 Aug 14;15(16):2844. doi: 10.3390/foods15162844. PMID- 42650452 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Aug 20 TI - AI-Enabled Physical Activity Intervention Strategies for Children and Adolescents: A Scoping Review. LID - 10.3390/children13081114 [doi] LID - 1114 AB - BACKGROUND/OBJECTIVES: Most children and adolescents do not meet recommended physical activity (PA) levels. Artificial intelligence (AI) may enable personalized and adaptive interventions, but evidence across delivery formats remains unclear. This scoping review mapped AI-enabled PA interventions for children and adolescents aged 6-18 years. METHODS: Following PRISMA-ScR and Joanna Briggs Institute guidance, six databases were searched on 24 May 2026 for English-language studies published since 2018. Eligible studies used AI in intervention delivery and empirically evaluated at least one participant-level PA-related outcome following exposure to the intervention. The review protocol was registered during data analysis. RESULTS: Seven studies published between 2022 and 2026 were included. Primary AI techniques were computer vision (n = 3), generative AI or large language models (n = 2), reinforcement learning (n = 1), and evolutionary computation (n = 1). Interventions included immersive systems (n = 2), conversational agents (n = 2), exergames or serious games (n = 2), and a robot (n = 1). Three studies used controlled designs and four were single-arm pilot or feasibility studies. CONCLUSIONS: AI supported movement recognition, content generation, personalization, and adaptive feedback. However, the small, heterogeneous, and predominantly early-stage evidence base precludes conclusions about effectiveness. Rigorous controlled studies and transparent AI-specific reporting are needed. FAU - Zhao, Junling AU - Zhao J AUID- ORCID: 0009-0007-8734-0444 AD - School of Public Health, Peking University, Beijing 100191, China. AD - China Center for Health Development Studies, Peking University, Beijing 100191, China. FAU - Huang, Jiandong AU - Huang J AD - School of Control and Computer Engineering, North China Electric Power University, Beijing 102206, China. FAU - Shang, Zhaoyang AU - Shang Z AD - Department of Applied Mathematics and Informatics, Shenzhen MSU-BIT University, Shenzhen 518172, China. FAU - He, Zhongkai AU - He Z AD - Department of Physical Education, Peking University, Beijing 100871, China. LA - eng PT - Journal Article PT - Review DEP - 20260820 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13510757 OTO - NOTNLM OT - adolescents OT - artificial intelligence OT - children OT - machine learning OT - physical activity OT - scoping review OT - sedentary behaviour COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:02 PHST- 2026/06/20 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - children13081114 [pii] AID - children-13-01114 [pii] AID - 10.3390/children13081114 [doi] PST - epublish SO - Children (Basel). 2026 Aug 20;13(8):1114. doi: 10.3390/children13081114. PMID- 42650439 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Aug 18 TI - Exploratory Biological Correlates of Cognitive and Language Performance in Healthy Pubertal Children: A Retrospective Cross-Sectional Study. LID - 10.3390/children13081101 [doi] LID - 1101 AB - Background/Objectives: Adolescence is a dynamic neurodevelopmental period during which structured language performance may reflect ongoing biological reorganization processes. This study examined whether inflammatory, nutritional, and hormonal biomarkers were modestly associated with structured language task performance and cognitive performance in healthy pubertal children. Methods: A total of 156 healthy pubertal children (78 female, 78 male; mean age of 11.84 +/- 2.98 years) meeting Tanner Stage >/= 2 were included in this retrospective cross-sectional study. Language was assessed with the Test of Language Development-Primary: Fourth Edition (TOLD-P:4; Turkish adaptation) and cognition with the Wechsler Intelligence Scale for Children-Revised (WISC-R). Pan-Immune-Inflammation Value (PIV), Prognostic Nutritional Index (PNI), Neutrophil-to-Lymphocyte Ratio (NLR), vitamin B12, 25-OH vitamin D, ferritin, and TSH were included as biomarkers. Two-block hierarchical OLS regression and Spearman correlations with Benjamini-Hochberg FDR correction were used. Results: The biomarker block provided a statistically significant incremental contribution to the spoken language model (DeltaR(2) = 0.066, p = 0.041; full model R(2) = 0.287). The primary test statistic was DeltaR(2). In exploratory coefficient-level analyses that were not corrected for multiple comparisons, the PIV (beta = +0.17, p = 0.033) and TSH (beta = -0.17, p = 0.031) coefficients reached nominal significance. After FDR correction, PIV was positively associated with WISC-R Verbal score (rho = +0.24, p_FDR = 0.019) and TSH negatively with TOLD-P:4 Speaking (rho = -0.22, p_FDR = 0.029). Biomarker contribution to WISC-R Full-Scale IQ was non-significant (DeltaR(2) = 0.049, p = 0.223). Conclusions: At the block level, the biomarker set contributed significantly to the structured spoken-language model but not to the Full-Scale IQ model; however, one of the two FDR-significant bivariate associations involved a verbal cognitive measure (PIV with WISC-R Verbal). Any language-versus-cognition contrast should therefore be interpreted cautiously. The modest effect sizes suggest these relationships are best interpreted within a developmental and neuroimmune framework. Longitudinal and multimodal studies are needed to replicate these findings. Because the TOLD-P:4/TODIL was applied beyond its validated age range (4; 0-8; 11) and its cross-age scoring could not be verified from the retrospective records, all language-based findings are exploratory and require confirmation with an age-validated instrument; the study's confirmatory finding is the FDR-significant association of PIV with age-appropriate WISC-R Verbal performance. Because the TOLD-P:4/TODIL composite scores could not be verified as comparable across the sample's age range, all TOLD-P:4-based results reported here are exploratory and hypothesis-generating; the confirmatory analyses rely on the age-appropriate WISC-R outcomes. FAU - Savas, Merve AU - Savas M AUID- ORCID: 0000-0002-7138-2603 AD - Department of Speech and Language Therapy, Faculty of Health Sciences, Istanbul Atlas University, 34403 Istanbul, Turkiye. FAU - Kahraman Begen, Senanur AU - Kahraman Begen S AUID- ORCID: 0000-0001-6938-301X AD - Department of Speech and Language Therapy, Faculty of Health Sciences, Istanbul Atlas University, 34403 Istanbul, Turkiye. FAU - Okuyan, Omer AU - Okuyan O AUID- ORCID: 0009-0006-6364-8615 AD - Department of Pediatrics, Faculty of Medicine, Istanbul Atlas University, 34403 Istanbul, Turkiye. FAU - Uzun, Hafize AU - Uzun H AUID- ORCID: 0000-0002-1347-8498 AD - Department of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, 34403 Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260818 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13511123 OTO - NOTNLM OT - children OT - cognitive performance OT - language development OT - neurodevelopment OT - puberty COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/18 CRDT- 2026/08/27 01:02 PHST- 2026/05/20 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - children13081101 [pii] AID - children-13-01101 [pii] AID - 10.3390/children13081101 [doi] PST - epublish SO - Children (Basel). 2026 Aug 18;13(8):1101. doi: 10.3390/children13081101. PMID- 42650436 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Aug 18 TI - Ratio That Reveals Risk: Defining TG:HDL-C Ratio Cutoff for Insulin Resistance in Adolescents with Obesity. LID - 10.3390/children13081098 [doi] LID - 1098 AB - Background/Objectives: Insulin resistance (IR) plays a central role in metabolic dysfunction and elevates the risk of chronic diseases such as type 2 diabetes mellitus in later life. Early identification of IR in adolescents is therefore important. This study aimed to determine the triglyceride-to-high-density lipoprotein cholesterol (TG:HDL-C) ratio cutoff for IR and assess its association with IR predictors among adolescents with obesity. Methods: A total of 215 blood samples from adolescents aged 13-16 years with obesity were analyzed for fasting blood glucose, lipids, insulin, leptin, and adiponectin. Obesity was defined using BMI z-scores, while IR was classified using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR >/= 4.0). Receiver operating characteristic (ROC) analysis was performed to compare the discriminatory performance between the TG:HDL-C ratio and Leptin:Adiponectin ratio (LAR). Multiple logistic regression was performed to assess associations between the TG:HDL-C ratio and IR-related markers. Results: The area under the ROC curve for the TG:HDL-C ratio was comparable to LAR (0.73 vs. 0.68, p = 0.3). The optimal TG:HDL-C ratio cutoff identified using the maximum Youden index was 0.89, with 62% sensitivity and 75% specificity. A TG:HDL-C ratio >/= 0.89 was associated with higher odds of elevated insulin (AOR 1.1, 95% CI 1.0-1.13), elevated HbA1c (AOR 2.7, 95% CI 1.1-6.6), abdominal obesity (AOR 3.6, 95% CI 1.9-6.7), and raised LAR (AOR 1.2, 95% CI 1.0-1.5). Conclusions: These findings suggest that a TG:HDL-C ratio cutoff of 0.89 may be a useful marker for identifying IR in adolescents with obesity. FAU - Iwani, Ahmad Kamil Nur Zati AU - Iwani AKNZ AUID- ORCID: 0009-0005-7376-4735 AD - Endocrine and Metabolic Unit, Nutrition, Metabolic, and Cardiovascular Research Center, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia. FAU - Jalaludin, Muhammad Yazid AU - Jalaludin MY AUID- ORCID: 0000-0003-4513-8444 AD - Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia. FAU - Yahya, Abqariyah AU - Yahya A AD - Department of Social and Preventive Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia. FAU - Abdullah, Shazana Rifham AU - Abdullah SR AD - Endocrine and Metabolic Unit, Nutrition, Metabolic, and Cardiovascular Research Center, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia. FAU - Ahmad Zamri, Liyana AU - Ahmad Zamri L AUID- ORCID: 0000-0003-0306-4897 AD - Endocrine and Metabolic Unit, Nutrition, Metabolic, and Cardiovascular Research Center, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia. FAU - Mansor, Fazliana AU - Mansor F AD - Endocrine and Metabolic Unit, Nutrition, Metabolic, and Cardiovascular Research Center, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia. FAU - Hong, Janet Yeow Hua AU - Hong JYH AD - Department of Paediatrics, Hospital Putrajaya, Ministry of Health Malaysia, Putrajaya 62250, Malaysia. FAU - Mokhtar, Abdul Halim AU - Mokhtar AH AUID- ORCID: 0000-0001-8057-313X AD - Department of Sports Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia. LA - eng GR - NMRR-18-2749-41841/MINISTRY OF HEALTH MALAYSIA/ PT - Journal Article DEP - 20260818 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13511121 OTO - NOTNLM OT - TG:HDL-C ratio OT - adolescents OT - cutoff OT - insulin resistance OT - obesity COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/18 CRDT- 2026/08/27 01:02 PHST- 2026/05/25 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - children13081098 [pii] AID - children-13-01098 [pii] AID - 10.3390/children13081098 [doi] PST - epublish SO - Children (Basel). 2026 Aug 18;13(8):1098. doi: 10.3390/children13081098. PMID- 42650380 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Aug 5 TI - Machine Learning-Based Prediction of Six-Minute Walk Distance in Children with Obesity. LID - 10.3390/children13081043 [doi] LID - 1043 AB - Background: The six-minute walk test (6MWT) assesses functional exercise capacity, but existing reference equations for children with obesity rely on traditional linear regression, potentially overlooking complex, non-linear relationships between anthropometric characteristics and functional exercise capacity. Objective: This study aimed to develop and internally validate machine-learning (ML) prediction models and preliminary prediction equations derived from explainable ML models for six-minute walk distance (6MWD) in Tunisian school-aged children with obesity and to compare their predictive performance with a conventional regression-based approach. Methods: We analyzed data from 236 school-aged children with obesity (104 females, 132 males; 6-12 years). Anthropometric measurements included body mass (BM), height, body mass index (BMI), waist circumference (WC), and hip circumference (HC). Five models were evaluated: linear regression, Ridge, Lasso, Elastic Net, and XGBoost. Performance was assessed using five-fold cross-validation and evaluated by the mean absolute error (MAE) and root mean square error (RMSE). Predictor importance was assessed using SHapley Additive exPlanation (SHAP) and Gini importance. Results: XGBoost achieved the best predictive performance, with the lowest MAE (17.4 +/- 2.5 m in females and 19.5 +/- 1.9 m in males) and RMSE (25.3 +/- 3.1 m in females and 26.4 +/- 2.2 m in males). Age was the strongest predictor across all models (SHAP: 54.2-62.0%; Gini importance: 0.52-0.69), followed by height and BMI. Sex-specific analyses indicated that, in females, age and BMI contributed ~80% to the cumulative SHAP analysis; whereas, in males, age, height, and WC were the primary factors. Conclusions: ML, particularly XGBoost, significantly improves 6MWD prediction in school-aged children with obesity compared with traditional linear regression. Explainable ML increases model interpretability by evaluating the relative importance of anthropometric predictors. These obesity-specific prediction models may better capture complex non-linear associations between anthropometrics and functional exercise capacity. These initial population-specific models should be validated in larger independent samples before routine use clinical or field settings. FAU - Makni, Emna AU - Makni E AUID- ORCID: 0009-0001-2941-1095 AD - Research Laboratory of Exercise Physiology and Pathophysiology (LR19ES09), Faculty of Medicine Ibn Al-Jazzar, University of Sousse, Sousse 4002, Tunisia. FAU - Elloumi, Mohamed AU - Elloumi M AUID- ORCID: 0000-0003-3751-2125 AD - Sport Sciences and Diagnostics Research Group, College of Sciences and Humanities, Prince Sultan University, Riyadh 11586, Saudi Arabia. FAU - Ammar, Achraf AU - Ammar A AUID- ORCID: 0000-0003-0347-8053 AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. AD - Research Laboratory, Molecular Bases of Human Pathology (LR19ES13), Faculty of Medicine of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman 11942, Jordan. FAU - Brahim, Mehdi Ben AU - Brahim MB AUID- ORCID: 0000-0001-8439-0429 AD - Sport Sciences and Diagnostics Research Group, College of Sciences and Humanities, Prince Sultan University, Riyadh 11586, Saudi Arabia. FAU - Hachana, Younes AU - Hachana Y AD - Research Laboratory (LR23JS01) "Sport Performance, Health & Society", Higher Institute of Sport and Physical Education of Ksar Said, University of "La Manouba", Manouba 2037, Tunisia. LA - eng PT - Journal Article DEP - 20260805 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13511065 OTO - NOTNLM OT - anthropometry OT - explainable artificial intelligence OT - functional exercise capacity OT - pediatric obesity OT - predictive modelling COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/05 CRDT- 2026/08/27 01:02 PHST- 2026/07/03 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - children13081043 [pii] AID - children-13-01043 [pii] AID - 10.3390/children13081043 [doi] PST - epublish SO - Children (Basel). 2026 Aug 5;13(8):1043. doi: 10.3390/children13081043. PMID- 42650315 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Jul 23 TI - Biochemical and Inflammatory Profiles in Paediatric Obesity, Undernutrition and Normal Weight: A Single-Centre Retrospective Cohort Study. LID - 10.3390/children13080975 [doi] LID - 975 AB - Background: We compared biochemical, micronutrient-related and complete blood count (CBC)-derived inflammatory profiles among children with obesity, undernutrition and normal weight, and explored the discriminatory performance of selected routine laboratory markers for the obesity phenotype. Methods: In this single-centre retrospective comparative study, medical records of children aged 2-17 years evaluated between January 2023 and December 2025 were reviewed. Participants were classified as obese, undernourished or normal weight using World Health Organization (WHO) body mass index-for-age (BMI-for-age) references. Liver enzymes, lipid parameters, iron-related indices, micronutrient levels, zinc, insulin and CBC-derived inflammatory indices were compared across groups using non-parametric omnibus tests. Exploratory receiver operating characteristic (ROC) analyses were performed for selected markers. Results: A total of 690 children were included: 100 with obesity, 90 with undernutrition and 500 with normal weight. The obesity group was significantly older than the normal-weight group (median 11.0 vs. 7.5 years; p < 0.001). Obesity was characterised by higher alanine aminotransferase (ALT), insulin, triglycerides, neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), together with lower high-density lipoprotein (HDL) cholesterol, 25-hydroxyvitamin D [25(OH)D] and aspartate aminotransferase-to-alanine aminotransferase (AST/ALT) ratio (all p < 0.05). In exploratory, age-unadjusted ROC analyses, the AST/ALT ratio yielded the highest AUC among the evaluated biomarkers (AUC 0.859; 95% CI 0.823-0.895; optimal cut-off /=15 y) from 45 surveys in 26 countries accessed from the FAO/WHO Global Individual Food Consumption Data Tool were analyzed. Multilevel linear and modified Poisson regression models quantified associations between PHDI, FGDS, GDQS+, and GDQS- with reference measures [e.g., mean adequacy ratio (MAR), % energy from ultraprocessed food (UPF)] or indicators of a healthy diet [e.g., >/=400 g/d of fruits and vegetables (F&V)], respectively. RESULTS: Adherence to PHDI was highest in low income (LIC) and lower-middle income countries (LMIC), and lowest in upper-middle income (UMIC) and high income countries (HIC). One-SD increments in PHDI were associated with higher MAR beta: 5.49 percentage points [pp]; [95% confidence interval (CI): 3.65 pp, 7.33 pp] in LIC to beta: 1.41 pp [95% CI: 1.23 pp, 1.58 pp] in UMIC, appropriate F&V intakes [relative risk (RR): 2.41 (95% CI: 1.85, 2.49) in UMIC to RR: 1.19 (95% CI: 1.05, 1.34) in LMIC], lower unprocessed red meat [beta: -10.0 g/d (95% CI: -11.4 g/d, -8.73 g/d) in LIC to beta: -6.86 g/d (95% CI: -7.54 g/d, -6.17 g/d) in UMIC], and lower proportions of energy from UPF [beta: -2.47 pp (95% CI: -3.77 pp, -1.18 pp) in LMIC to beta: -1.21 pp (95% CI: -2.32 pp, 0.105 pp) in LIC]; however, 1-SD increases in FGDS and GDQS+ outperformed PHDI in predicting measures of nutrient adequacy, particularly MAR [beta for FGDS: 11.2 pp (95% CI: 9.13 pp, 13.3 pp) in LIC to beta for FGDS: 8.57 pp (95% CI: 8.42 pp, 8.72 pp) in UMIC; beta for GDQS+: 9.82 pp (95% CI: 7.26 pp, 12.4 pp) in LMIC to beta for GDQS+: 7.18 pp (95% CI: 6.00 pp, 8.36 pp) in HIC] and appropriate F&V intakes [RR for FGDS: 2.78 (95% CI: 2.26, 3.41) in LMIC to RR for FGDS: 1.63 (95% CI: 1.22, 2.19) in HIC; RR for GDQS+: 2.39 (95% CI: 1.89, 2.89) in LMIC to RR for GDQS+: 1.55 (95% CI: 1.16, 1.96) in LIC]. CONCLUSIONS: PHDI may serve as a robust, dual-purpose measure for monitoring adherence to diets that are both sustainable and healthy in contexts with regular quantitative dietary intake assessments and low burdens of diet-related undernutrition. However, simpler food group-based measures, such as the FGDS, often show stronger associations with healthy diet subconstructs, such as nutrient adequacy, and are more feasible for large-scale, routine monitoring of diets. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Hanley-Cook, Giles T AU - Hanley-Cook GT AD - Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium. Electronic address: giles.hanleycook@ugent.be. FAU - van der Meulen, Emma AU - van der Meulen E AD - Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium. FAU - Beal, Ty AU - Beal T AD - Global Alliance for Improved Nutrition, Washington, DC, United States. FAU - Cacau, Leandro Teixeira AU - Cacau LT AD - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil; Center for Epidemiological Research in Nutrition and Health, University of Sao Paulo, Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260826 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - *Diet, Healthy MH - Male MH - Cross-Sectional Studies MH - World Health Organization MH - Adult MH - Adolescent MH - Diet Records MH - Young Adult MH - Global Health MH - *Diet Surveys MH - Middle Aged MH - Diet MH - Energy Intake MH - Feeding Behavior OTO - NOTNLM OT - GDQS OT - MDD-W OT - Planetary Health Diet OT - dietary diversity OT - fruit and vegetable intake OT - moderation OT - nutrient adequacy OT - ultraprocessed foods OT - unprocessed red meat COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/08/26 23:35 MHDA- 2026/10/05 23:29 CRDT- 2026/08/26 19:15 PHST- 2025/11/08 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/10/05 23:29 [medline] PHST- 2026/08/26 23:35 [pubmed] PHST- 2026/08/26 19:15 [entrez] AID - S0002-9165(26)00304-7 [pii] AID - 10.1016/j.ajcnut.2026.101495 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Oct;124(4):101495. doi: 10.1016/j.ajcnut.2026.101495. Epub 2026 Aug 26. PMID- 42648534 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 409 DP - 2026 Nov 15 TI - Quantitative decoupling of source-pathway-receptor driving mechanisms for integrated soil risk via interpretable machine learning. PG - 129052 LID - S0269-7491(26)01422-3 [pii] LID - 10.1016/j.envpol.2026.129052 [doi] AB - Most existing concentration-based risk assessments of potentially toxic elements (PTEs) in farmland soils tend to overlook source-specific transport pathways and receptor-related risks. In this study, an integrated risk index-machine learning framework based on the source-pathway-receptor concept is developed to comprehensively evaluate PTE risks in a typical mining city. The framework integrates the improved Nemerow index (INI), potential ecological risk index, Monte Carlo simulation-based health risk assessment, and machine learning models to identify and differentiate industrial and agricultural risk mechanisms. Results showed that industrial sources exhibited higher INI values than agricultural sources, indicating stronger pollution accumulation. Industrial risks were predominantly associated with atmospheric deposition and surface runoff pathways. Receptor-based health risk assessments further revealed that children were highly vulnerable to exposure to industrial PTEs, with chromium identified as the dominant contributor to carcinogenic risk. By contrast, agricultural risks were mainly attributed to internal receptors (26.80%) and inputs from irrigation, fertilizers and animal manure (23.20%). Among the agricultural risk zones, dietary exposure through crop consumption represented a crucial pathway, with oilseed rape demonstrating the highest potential health risks. Carcinogenic and non-carcinogenic risks associated with oilseed rape exceed acceptable thresholds. Furthermore, the XGBoost regression model achieved satisfactory predictive performance under an internal 8:2 training-testing validation, with R(2) values of 0.823 and 0.716, respectively. SHAP analysis further revealed different dominant factors governing industrial and agricultural risks. Overall, the proposed framework provides a basis for targeted zoned control and may help avoid excessive remediation in low-risk areas while ensuring sufficient control in high-risk areas. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Su, Chuanghong AU - Su C AD - College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, China; Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtze River), Ministry of Agriculture, China. FAU - Yang, Yong AU - Yang Y AD - College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, China; Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtze River), Ministry of Agriculture, China. Electronic address: yangyong@mail.hzau.edu.cn. FAU - Fu, Peihong AU - Fu P AD - College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, China; Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtze River), Ministry of Agriculture, China. LA - eng PT - Journal Article DEP - 20260827 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Soil Pollutants) RN - 0 (Soil) SB - IM MH - *Machine Learning MH - *Soil Pollutants/analysis MH - Risk Assessment MH - *Environmental Monitoring/methods MH - Agriculture MH - *Soil/chemistry MH - Mining MH - Environmental Pollution/statistics & numerical data MH - Boosting Machine Learning Algorithms OTO - NOTNLM OT - Machine learning OT - Monte Carlo simulation OT - Potentially toxic elements OT - Risk assessment OT - Source-pathway-receptor COIS- Declaration of competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/26 23:35 MHDA- 2026/10/15 07:17 CRDT- 2026/08/26 19:13 PHST- 2026/06/24 00:00 [received] PHST- 2026/08/23 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/10/15 07:17 [medline] PHST- 2026/08/26 23:35 [pubmed] PHST- 2026/08/26 19:13 [entrez] AID - S0269-7491(26)01422-3 [pii] AID - 10.1016/j.envpol.2026.129052 [doi] PST - ppublish SO - Environ Pollut. 2026 Nov 15;409:129052. doi: 10.1016/j.envpol.2026.129052. Epub 2026 Aug 27. PMID- 42648412 OWN - NLM STAT- Publisher LR - 20260902 IS - 1872-7573 (Electronic) IS - 0378-8741 (Linking) VI - 374 IP - Pt 1 DP - 2026 Aug 26 TI - Pharmacodynamic-oriented serum pharmacochemistry-based discovery of the pharmacodynamic material basis and mechanism of Ohwia caudata leaves against acute ulcerative colitis. PG - 122326 LID - S0378-8741(26)01181-5 [pii] LID - 10.1016/j.jep.2026.122326 [doi] AB - ETHNOPHARMACOLOGICAL RELEVANCE: Ohwia caudata leaves have long been used in traditional Chinese medicine to treat dysentery, gastroenteritis, and infantile malnutrition. However, their effect on ulcerative colitis (UC) remains unclear. AIM OF THE STUDY: This study aimed to investigate the pharmacodynamic material basis and underlying mechanism of O. caudata leaves against acute UC. MATERIALS AND METHODS: An acute UC mouse model was induced by 2.5% dextran sulfate sodium (DSS) to evaluate the pharmacodynamics of the 70% ethanol extract and different extraction/elution fractions of O. caudata leaves. The chemical constituents of the most active fraction were isolated and identified using various chromatographic and spectroscopic techniques. Serum pharmacochemistry coupled with LC-MS was employed to identify prototype components absorbed into the blood. The anti-inflammatory activity of the absorbed components was screened by measuring nitric oxide (NO) production in LPS-stimulated RAW264.7 cells. Network pharmacology was used to predict the potential targets and pathways of the active components, and key signaling pathways were validated by Western blot. RESULTS: The 95% ethanol elution fraction (OCLH) was identified as the main anti-UC active fraction. From this fraction, 81 compounds were isolated and identified, including aliphatic glycosides, ionone glycosides, flavonoid glycosides, etc. 27 prototype components were found to enter the bloodstream, among which 16 exhibited significant inhibitory activity against NO production. Representative flavonoid C-glycosides (compounds 25, 30, 31, 38) significantly suppressed the phosphorylation levels of p38, Erk1/2, and AKT, and down-regulated the protein expression of PI3K, IL-6, and TNF-alpha in LPS-stimulated RAW264.7 cells. CONCLUSION: The 95% ethanol elution fraction of O. caudata leaves is the main pharmacodynamic fraction responsible for ameliorating acute UC. Flavonoid C-glycosides are the key active components, and their mechanism is associated with the intervention of TNF-mediated MAPK and PI3K-AKT signaling pathways. This study provides a scientific basis for the rational clinical application of O. caudata leaves and the discovery of anti-UC lead compounds. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Ruan, Jingya AU - Ruan J AD - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Zhang, Qianqian AU - Zhang Q AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Geng, Qianqian AU - Geng Q AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Wu, Yijin AU - Wu Y AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Liu, Qian AU - Liu Q AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Zhang, Ping AU - Zhang P AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Zhang, Yi AU - Zhang Y AD - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. Electronic address: zhwwxzh@tjutcm.edu.cn. FAU - Wang, Tao AU - Wang T AD - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. Electronic address: wangtao@tjutcm.edu.cn. LA - eng PT - Journal Article DEP - 20260826 PL - Ireland TA - J Ethnopharmacol JT - Journal of ethnopharmacology JID - 7903310 SB - IM OTO - NOTNLM OT - Mechanism of action OT - Pharmacological substances OT - TNF/MAPK/PI3K-AKT signaling pathway OT - The leaves of O. caudata OT - Ulcerative colitis COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors have used DeepSeek for language polishing of this manuscript. EDAT- 2026/08/26 23:35 MHDA- 2026/08/26 23:35 CRDT- 2026/08/26 19:11 PHST- 2026/06/23 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/22 00:00 [accepted] PHST- 2026/08/26 23:35 [pubmed] PHST- 2026/08/26 23:35 [medline] PHST- 2026/08/26 19:11 [entrez] AID - S0378-8741(26)01181-5 [pii] AID - 10.1016/j.jep.2026.122326 [doi] PST - aheadofprint SO - J Ethnopharmacol. 2026 Aug 26;374(Pt 1):122326. doi: 10.1016/j.jep.2026.122326. PMID- 42647367 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 3 DP - 2026 Aug 22 TI - Comparison of Anthropometric Equations to Estimate Body Composition in Chilean Male Adolescent Soccer Players. LID - 10.3390/jfmk11030326 [doi] LID - 326 AB - Background: Anthropometric body-composition assessment in youth soccer commonly relies on equations developed in different source populations and based on distinct body-composition models, potentially altering nutritional and sport-related interpretation. This study compared body-fat estimates from equations intended to report the same outcome, body fat percentage, but based on different operational models, and quantified muscle-mass outputs from anthropometric approaches targeting total-body skeletal, whole-body, and tissue-level muscle compartments in a cohort of Chilean male U-15 and U-16 players. Methods: This secondary cross-sectional method-comparison study analyzed anonymized anthropometric records collected in 2018 from 50 male players. Slaughter, Faulkner, Carter, Deurenberg, and Sloan-Siri estimates of body fat were compared, together with Poortmans, Lee, Doupe, and Kerr muscle-mass approaches. Absolute agreement among adiposity equations was evaluated using a two-way random-effects, absolute-agreement, single-measure ICC [ICC(A,1)] and Bland-Altman analyses. Muscle-mass approaches were compared with repeated-measures analysis; pairwise difference-versus-mean summaries across different muscle constructs were interpreted descriptively rather than as formal agreement tests. Sensitivity analyses excluded Deurenberg and examined a maturation-related Slaughter scenario. Results: Deurenberg yielded the highest body-fat estimate (18.97 +/- 3.07%), followed by Slaughter (13.32 +/- 3.35%), Faulkner (10.84 +/- 1.40%), Sloan-Siri (8.01 +/- 2.80%), and Carter (7.91 +/- 1.49%). Global differences were large (chi(2)(4) = 182.96; p < 0.001; Kendall's W = 0.915), and individual absolute agreement was low [ICC(A,1) = 0.157; bootstrap 95% CI 0.102-0.212]. Excluding Deurenberg did not remove the between-method differences (chi(2)(3) = 124.44; p < 0.001; W = 0.830). For muscle mass, mean estimates ranged from 25.11 +/- 3.07 kg with Poortmans to 31.26 +/- 4.94 kg with Doupe, with a significant method effect after Greenhouse-Geisser correction (p < 0.001). Conclusions: The adiposity equations yielded substantially different numerical estimates of the same reported outcome, body fat percentage, and showed low individual-level absolute agreement. Muscle-mass approaches also produced large numerical differences, partly expected because they target different compartments. Outputs from different equations or constructs should not be treated as numerically interchangeable. Because no criterion reference method was included, this study quantifies method dependence rather than validity and cannot identify the most accurate equation. FAU - Farfan-Diaz, Alvaro AU - Farfan-Diaz A AUID- ORCID: 0009-0000-2435-0185 AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad de Tarapaca, Arica 1000000, Chile. FAU - Alarcon-Rivera, Miguel AU - Alarcon-Rivera M AUID- ORCID: 0000-0001-8341-5567 AD - Escuela de Ciencias del Deporte y Actividad Fisica, Facultad de Salud, Universidad Santo Tomas, Talca 3460000, Chile. FAU - Andrade Oyarzun, Marcelo AU - Andrade Oyarzun M AUID- ORCID: 0009-0008-9430-2646 AD - Departamento de Nutricion y Dietetica, Universidad de Magallanes, Punta Arenas 6210427, Chile. AD - Centro Asistencial de Docencia e Investigacion, Universidad de Magallanes (CADI-UMAG), Punta Arenas 6210427, Chile. FAU - Tapia-Villanueva, Daniel AU - Tapia-Villanueva D AUID- ORCID: 0009-0005-8414-7791 AD - Independent Researcher, Santiago 8320000, Chile. FAU - Garcia-Carrillo, Exal AU - Garcia-Carrillo E AUID- ORCID: 0000-0001-6190-938X AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3480112, Chile. AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. FAU - Molina-Marquez, Ivan AU - Molina-Marquez I AUID- ORCID: 0000-0001-6003-5107 AD - Pedagogia en Educacion Fisica, Facultad de Educacion, Universidad Adventista de Chile, Chillan 3780000, Chile. AD - Programa Doctorado en Ciencias de la Actividad Fisica, Universidad Catolica del Maule, Talca 3460000, Chile. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Escuela de Ciencias del Deporte, Facultad de Educacion y Humanidades, Universidad Andres Bello, Vina del Mar 2200055, Chile. AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. FAU - Barrera-Gonzalez, Dario AU - Barrera-Gonzalez D AUID- ORCID: 0000-0003-4799-341X AD - Carrera de Kinesiologia, Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Talca 3460000, Chile. FAU - Montalva-Valenzuela, Felipe AU - Montalva-Valenzuela F AUID- ORCID: 0000-0003-0004-3089 AD - Escuela de Entrenador en Actividad Fisica y Deporte, Facultad de Ciencias Humanas, Universidad Bernardo O'Higgins, Santiago 8370993, Chile. LA - eng PT - Journal Article DEP - 20260822 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13511747 OTO - NOTNLM OT - adiposity OT - body composition OT - kinanthropometry OT - method comparison OT - skeletal muscle OT - youth soccer COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/08/22 CRDT- 2026/08/26 12:54 PHST- 2026/07/17 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 12:54 [entrez] PHST- 2026/08/22 00:00 [pmc-release] AID - jfmk11030326 [pii] AID - jfmk-11-00326 [pii] AID - 10.3390/jfmk11030326 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Aug 22;11(3):326. doi: 10.3390/jfmk11030326. PMID- 42647249 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2409-515X (Electronic) IS - 2409-515X (Linking) VI - 12 IP - 3 DP - 2026 Jul 30 TI - Experience with Implementation of Pulse Oximetry Screening for Critical Congenital Heart Disease in a Low-Middle-Income Country. LID - 10.3390/ijns12030062 [doi] LID - 62 AB - The adoption of pulse oximetry screening (POS) in low- and middle-income countries remains limited. We describe the development, implementation, and evaluation of a POS program at two of the leading tertiary centers in Accra, Ghana, based on a modified American Academy of Pediatrics protocol. Screening was conducted by trained research assistants. Operational experiences of research assistants were evaluated using a mixed-methods approach, including post-implementation surveys (n = 14) and focus group discussions (n = 10). Although participants felt comfortable with the level of instruction, they recommended incorporating simulation exercises to strengthen management of failed screens. Key challenges included difficulty locating newborns due to fragmented wards and paper-based records, equipment durability issues, and complex coordination for echocardiography following failed screens. Early discharge practices and high neonatal intensive care unit admissions reduced screening coverage among high-risk infants. Despite limited referral systems and surgical capacity, the POS pilot increased provider awareness, improved diagnostic clarity and demonstrated feasibility. Sustainable expansion will require more efficient referral networks as well as investment in pediatric cardiology training and cardiac surgical infrastructure. FAU - Adaboh, Abena AU - Adaboh A AD - David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. FAU - Celestin, Daem AU - Celestin D AD - David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. FAU - Agyekum, Alex AU - Agyekum A AD - Korle Bu Teaching Hospital, Accra GA-221-1570, Ghana. FAU - Osei, Nana Serwaa AU - Osei NS AD - Korle Bu Teaching Hospital, Accra GA-221-1570, Ghana. FAU - Mensah, Araba AU - Mensah A AD - Korle Bu Teaching Hospital, Accra GA-221-1570, Ghana. FAU - Sayeed, Sadath AU - Sayeed S AUID- ORCID: 0009-0003-5841-218X AD - David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. FAU - Yao, Nana-Akyaa AU - Yao NA AD - Korle Bu Teaching Hospital, Accra GA-221-1570, Ghana. LA - eng PT - Journal Article DEP - 20260730 PL - Switzerland TA - Int J Neonatal Screen JT - International journal of neonatal screening JID - 101665400 PMC - PMC13511312 OTO - NOTNLM OT - challenges OT - critical congenital heart disease OT - implementation OT - low resource OT - pulse oximetry screening OT - sub-Saharan Africa COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/07/30 CRDT- 2026/08/26 12:53 PHST- 2026/02/28 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/24 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 12:53 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - ijns12030062 [pii] AID - IJNS-12-00062 [pii] AID - 10.3390/ijns12030062 [doi] PST - epublish SO - Int J Neonatal Screen. 2026 Jul 30;12(3):62. doi: 10.3390/ijns12030062. PMID- 42647245 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2409-515X (Electronic) IS - 2409-515X (Linking) VI - 12 IP - 3 DP - 2026 Jul 28 TI - Newborn Screening for Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency and Analysis of SLC25A13 Gene Mutations in Hefei, China. LID - 10.3390/ijns12030058 [doi] LID - 58 AB - Citrin deficiency (CD) is an autosomal recessive disorder and represents one of the urea cycle disorders. This study aims to analyze the detection rate, clinical features, and genetic mutation characteristics of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in the Hefei region of China. We conducted NICCD screening using tandem mass spectrometry (MS/MS) for infants born in Hefei City between January 2016 and December 2025. Screen-positive cases were subjected to genetic testing via next-generation sequencing (NGS), with subsequent validation by Sanger sequencing. Clinical manifestations, biochemical parameters, and genetic mutation profiles of confirmed cases were systematically analyzed. A total of 924,676 newborns underwent screening, identifying 17 cases of NICCD, yielding a detection rate of 1/54,393, with two false-negative cases identified. The most prevalent mutation site is c.852_855del (p.M285Pfs*2). Following diagnosis, health education, dietary guidance, and symptomatic treatment were administered, resulting in favorable outcomes in the majority of cases. However, one infant exhibited significant growth retardation despite early therapeutic intervention that normalized biochemical parameters. Furthermore, an infant was found to have gallstones at birth and subsequently diagnosed with a liver hemangioma at one year of age. Some patients may experience missed screenings due to delayed elevations in citrulline levels. Therefore, even for newborns with negative screening results, timely assessments of liver function, MS/MS, and genetic testing are recommended for infants experiencing prolonged jaundice. This approach enables early identification and intervention. The combination of MS/MS with genetic screening may serve as a reliable strategy to reduce false-negative results in NICCD screening. FAU - Ma, Qingqing AU - Ma Q AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230022, China. AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Chen, Junxing AU - Chen J AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230022, China. FAU - Huang, Yong AU - Huang Y AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Wang, Yan AU - Wang Y AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Song, Wangsheng AU - Song W AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Xu, Hongyu AU - Xu H AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Wan, Yuhui AU - Wan Y AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230022, China. FAU - Hu, Haili AU - Hu H AUID- ORCID: 0009-0008-8390-406X AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230022, China. AD - Anhui Women and Children's Medical Center, Hefei 230001, China. LA - eng GR - hhw-2016yb016/Hefei Municipal Health Commission/ GR - AHWJ2024Aa20311/Health Commission of Anhui Province/ PT - Journal Article DEP - 20260728 PL - Switzerland TA - Int J Neonatal Screen JT - International journal of neonatal screening JID - 101665400 PMC - PMC13510412 OTO - NOTNLM OT - SLC25A13 gene OT - neonatal intrahepatic cholestasis caused by citrin deficiency OT - newborn screening OT - tandem mass spectrometry COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/07/28 CRDT- 2026/08/26 12:53 PHST- 2026/05/08 00:00 [received] PHST- 2026/07/18 00:00 [revised] PHST- 2026/07/26 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 12:53 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - ijns12030058 [pii] AID - IJNS-12-00058 [pii] AID - 10.3390/ijns12030058 [doi] PST - epublish SO - Int J Neonatal Screen. 2026 Jul 28;12(3):58. doi: 10.3390/ijns12030058. PMID- 42646607 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260918 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 4 DP - 2026 Aug 12 TI - Exercise-Based Interventions for the Management of Low Back Pain in Adolescents in School Settings: A Systematic Review. LID - 10.3390/medsci14040473 [doi] LID - 473 AB - BACKGROUND/OBJECTIVES: To synthesize the effects of school-based exercise interventions in adolescents with nonspecific low back pain. METHODS: PubMed/MEDLINE, Scopus, Web of Science, CENTRAL, PEDro, ScienceDirect, and supplementary sources were searched through 21 May 2026. Randomized and quasi-randomized controlled trials involving adolescents aged 10-19 years and delivering exercise wholly or substantially within schools were eligible. Risk of bias was assessed using Cochrane RoB 1, and findings were synthesized narratively. RESULTS: Of 1935 records, two randomized trials and one quasi-experimental controlled trial (194 allocated participants) were included. Fanucchi et al. reported between-group reductions in past-month pain of 2.2 cm on a 10-cm visual analogue scale (95% CI 1.0-3.5) at 3 months and 2.0 cm (95% CI 0.5-3.5) at 6 months; absolute reductions in 3-month low back pain prevalence were 24% (95% CI 4-41) and 40% (95% CI 18-57), respectively. Jones et al. reported a large effect size for pain severity after 8 weeks (ES = 1.47). Javadipour et al. reported favorable pain and motor-function outcomes, but incomplete and internally inconsistent reporting limited interpretation. No study assessed low-back-pain-related disability using a validated instrument. All studies had high risk of bias in at least one domain, most commonly blinding. Heterogeneity precluded meta-analysis. CONCLUSIONS: Limited evidence suggests that school-based exercise may reduce pain intensity and pain prevalence over six months and improve selected physical outcomes in adolescents aged 12-15 years. The small, heterogeneous evidence base and risk of bias preclude conclusions or recommendations regarding modality or dosage. FAU - Tarao, Gismael M AU - Tarao GM AUID- ORCID: 0009-0002-8648-0887 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Afonso, Joao Pedro R AU - Afonso JPR AUID- ORCID: 0000-0002-1392-4910 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Ribeiro, Alex S AU - Ribeiro AS AUID- ORCID: 0000-0002-0312-8857 AD - Faculty of Sports Sciences and Physical Education (FCDEF), University of Coimbra, CIPER, 3004-531 Coimbra, Portugal. FAU - Stocco, Marieli R AU - Stocco MR AD - Physhiotherapy Department, The State University of Northern Parana (UENP), Jacarezinho 86400-000, Brazil. FAU - Bovi, Adriana AU - Bovi A AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Barbosa, Ludymilla V AU - Barbosa LV AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Pinto, Andre L AU - Pinto AL AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Oliveira, Claudia S AU - Oliveira CS AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Carvalho, Karla C N de AU - Carvalho KCN AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Oliveira, Miria C AU - Oliveira MC AUID- ORCID: 0000-0002-5302-1388 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Quirino, Fernanda S P AU - Quirino FSP AUID- ORCID: 0009-0008-9420-6371 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Oliveira, Glauber A AU - Oliveira GA AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Sampaio, Andreia C R I AU - Sampaio ACRI AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Masri, Dunya O AU - Masri DO AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Oliveira, Luis V F AU - Oliveira LVF AUID- ORCID: 0000-0002-3852-9415 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Fernandes, Tiago V AU - Fernandes TV AD - Department Rehabilitation, Barretos Cancer Hospital, Barretos 14784-400, Brazil. AD - Health Sciences Graduate Program (PPGCS), Faculty of Medical Sciences (FCMSCSP), Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo 01221-010, Brazil. FAU - Filho, Hustenio A A AU - Filho HAA AD - Health Sciences Graduate Program (PPGCS), Faculty of Medical Sciences (FCMSCSP), Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo 01221-010, Brazil. FAU - Capodaglio, Paolo AU - Capodaglio P AUID- ORCID: 0000-0003-3719-8789 AD - Orthopaedic Rehabilitation Unit, Research Laboratory for Biomechanics, Rehabilitation and Ergonomics, Ospedale San Giuseppe, 20123 Milan, Italy. AD - Physical and Rehabilitation Medicine Sector, Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy. FAU - Maia, Luciana P AU - Maia LP AUID- ORCID: 0000-0001-5697-2587 AD - Dentistry Graduate Program, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Andraus, Rodrigo A C AU - Andraus RAC AUID- ORCID: 0000-0002-3849-0872 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260812 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Low Back Pain/therapy MH - Adolescent MH - *Exercise Therapy/methods MH - Schools MH - Child PMC - PMC13515185 OTO - NOTNLM OT - adolescents OT - exercise therapy OT - low back pain OT - rehabilitation OT - school-based intervention COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/08/12 CRDT- 2026/08/26 11:31 PHST- 2026/07/03 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 11:31 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - medsci14040473 [pii] AID - medsci-14-00473 [pii] AID - 10.3390/medsci14040473 [doi] PST - epublish SO - Med Sci (Basel). 2026 Aug 12;14(4):473. doi: 10.3390/medsci14040473. PMID- 42646535 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2039-4403 (Electronic) IS - 2039-439X (Print) IS - 2039-439X (Linking) VI - 16 IP - 8 DP - 2026 Aug 4 TI - Development of Thai-Specific Gestational Weight Gain Targets Using Asian BMI Cut-Points: Implications for Nursing and Midwifery Practice in Preventing Gestational Diabetes Mellitus. LID - 10.3390/nursrep16080274 [doi] LID - 274 AB - Background: Thai obstetric nurses follow WHO gestational weight gain (GWG) guidelines to prevent gestational diabetes mellitus (GDM). However, these Western-derived guidelines misclassify approximately 16% of Thai pregnant women, who carry excess metabolic risk at lower BMI values than Western populations. Objectives: To derive and validate Thai-specific GWG targets using Thai BMI cut-points across five BMI subgroups and assess implications for nursing practice in GDM prevention. Methods: Retrospective cohort study of 1396 Thai singleton pregnancies at a maternal and child hospital (2023-2025). GWG targets were derived as interquartile ranges (P25-P75) from a healthy-outcomes subgroup (n = 706), with validity confirmed by multivariable logistic regression and a 70:30 derivation/validation split. Results: GDM prevalence was 15.8%, with a rising crude trend that was attenuated after accounting for a mid-study change in screening protocol. Provisional Thai-specific GWG targets were underweight/normal weight 11.5-18.0 kg, overweight 9.7-18.0 kg, obesity class I 9.1-16.0 kg, and obesity class II+ 5.8-12.1 kg. Inadequate GWG in obesity class I was associated with a 3.92-fold GDM risk increase (aOR 3.92, 95% CI 2.12-7.24, p < 0.001). Adherence improved from 34.7% (IOM 2009) to 50.2% with Thai-specific targets. Conclusions: These Thai-specific GWG targets are provisional, single-centre pilot estimates. They appear clinically safe and are substantially more achievable than IOM 2009 criteria and are offered to inform BMI-appropriate antenatal counselling and to justify a multi-centre validation study, rather than as ranges that are ready for immediate national adoption. FAU - Xuto, Piyanut AU - Xuto P AUID- ORCID: 0000-0003-1338-0789 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Bressington, Daniel AU - Bressington D AUID- ORCID: 0000-0003-0951-2208 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Khiaokham, Lawitra AU - Khiaokham L AUID- ORCID: 0000-0002-4008-5446 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Khaw-On, Patompong AU - Khaw-On P AUID- ORCID: 0000-0002-9965-5319 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Matayaboon, Nantarat AU - Matayaboon N AUID- ORCID: 0009-0002-9365-0733 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Sangsawang, Suraphan AU - Sangsawang S AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Janta, Nantawan AU - Janta N AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Sungplipan, Pradab AU - Sungplipan P AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Wiangsuwan, Suratsawadee AU - Wiangsuwan S AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Chaiwatthanakorn, Sujitra AU - Chaiwatthanakorn S AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Phiwon, Ampaporn AU - Phiwon A AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Khetwang, Kamonchanok AU - Khetwang K AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Charuloedphong, Ratchaneewan AU - Charuloedphong R AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. LA - eng GR - The Chiang Mai University International Visiting Professor Fellowship scheme./Chiang Mai University/ PT - Journal Article DEP - 20260804 PL - Switzerland TA - Nurs Rep JT - Nursing reports (Pavia, Italy) JID - 101592662 PMC - PMC13516527 OTO - NOTNLM OT - Asian populations OT - antenatal care OT - body mass index OT - gestational diabetes mellitus OT - gestational weight gain OT - midwifery OT - nursing COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/08/04 CRDT- 2026/08/26 11:31 PHST- 2026/06/22 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 11:31 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - nursrep16080274 [pii] AID - nursrep-16-00274 [pii] AID - 10.3390/nursrep16080274 [doi] PST - epublish SO - Nurs Rep. 2026 Aug 4;16(8):274. doi: 10.3390/nursrep16080274. PMID- 42644700 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1938-2359 (Electronic) IS - 0090-4481 (Linking) VI - 55 IP - 8 DP - 2026 Aug TI - Structured Approach to Pediatric Acute Gastroenteritis: Discussion of Diagnostics and Treatment of Acute Gastroenteritis in Children. PG - e323-e327 LID - 10.3928/19382359-20260609-05 [doi] AB - Pediatric acute gastroenteritis remains a leading global cause of mortality and malnutrition, accounting for 1.7 billion annual cases. Despite its prevalence, management remains variable. This article advocates for a transition from unstructured clinical "gestalt" to evidence-based frameworks in order to improve outcomes. Diagnostic evaluation should prioritize validated tools, like the Clinical Dehydration Scale and the Gorelick Scale, as physician intuition often lacks precision. Laboratory diagnostics and polymerase chain reaction testing should be reserved for severe cases or patients with high risk to avoid over testing. Management emphasizes oral rehydration therapy as the gold standard for mild-to-moderate dehydration, supported by single-dose ondansetron to reduce intravenous (IV) fluid reliance and hospitalization. Antimicrobials are indicated only for specific pathogens (eg, Shigella, Vibrio cholerae) or immunocompromised hosts. Finally, there is discussion on systemic health disparities-noting that children who are Black and not Hispanic and children who are Hispanic are statistically less likely to receive IV fluids or admission-underscoring the role of standardized guidelines in ensuring equitable, high-value care. FAU - Traisman, Benjamin AU - Traisman B AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. FAU - Kilaru, Raga AU - Kilaru R AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. FAU - Parikh, Sonia AU - Parikh S AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. FAU - Listernick, Zoe AU - Listernick Z AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. AD - Northwestern University Feinberg School of Medicine, Chicago, Illinois. LA - eng PT - Journal Article PT - Review DEP - 20260801 PL - United States TA - Pediatr Ann JT - Pediatric annals JID - 0356657 SB - IM MH - Humans MH - *Gastroenteritis/diagnosis/therapy/complications MH - Acute Disease MH - Fluid Therapy/methods MH - Dehydration/therapy/etiology/diagnosis MH - Child COIS- Disclosure: The authors have disclosed no potential conflicts of interest, financial or otherwise. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 CRDT- 2026/08/26 09:46 PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 09:46 [entrez] AID - 10.3928/19382359-20260609-05 [doi] PST - ppublish SO - Pediatr Ann. 2026 Aug;55(8):e323-e327. doi: 10.3928/19382359-20260609-05. Epub 2026 Aug 1. PMID- 42644658 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 96 IP - 9 DP - 2026 Sep TI - Wearable-Supported Physical Education for Physical Activity and Psychosocial Beliefs in Underserved Adolescents. PG - e70219 LID - 10.1111/josh.70219 [doi] LID - e70219 AB - BACKGROUND: Despite well-established health benefits of moderate-to-vigorous physical activity (MVPA), many youth, especially from low-income households, remain insufficiently active. This study examined the feasibility and preliminary efficacy of a fitness wearable-supported intervention to increase MVPA in physical education (PE) classes among underserved adolescents. METHODS: Four PE classes (N = 55 enrolled; ages 11-14) at a low-income public school were assigned to either a two-week wearable-supported PE or usual PE, and analyses included the 52 students with pre- and post-assessment data. Feasibility benchmarks (recruitment, retention, data completeness, adherence, dose, technology) were compared against benchmarks set a priori. Between-group differences in change in MVPA (actigraphy) and psychosocial beliefs (questionnaires) were analyzed using ANCOVA or non-parametric equivalent tests. RESULTS: Recruitment, retention, data collection, and technology adherence benchmarks were met. A significant interaction for MVPA of in-class PE was observed (F(1, 47) = 14.60, p < 0.01, etap2 = 0.24), favoring the intervention group. No significant improvements in psychosocial beliefs were observed in either group. IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: Schools and health professionals may consider integrating digital health tools, aligned with evidence-based pedagogical strategies and behavior change techniques to facilitate health-enhancing physical activity. CONCLUSIONS: Self-monitoring and real-time feedback via fitness wearables may increase in-class engagement in MVPA among underserved adolescents, however, further studies are warranted to strengthen the evidence in this population. CI - (c) 2026 American School Health Association. FAU - Ryu, Suryeon AU - Ryu S AUID- ORCID: 0000-0002-8080-8821 AD - School of Kinesiology, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA. AD - Center for Children's Healthy Lifestyles and Nutrition, Children's Mercy, Kansas City, Missouri, USA. FAU - Kringle, Emily AU - Kringle E AD - School of Kinesiology, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA. FAU - Gao, Zan AU - Gao Z AD - Department of Kinesiology, Recreation, and Sport Studies, University of Tennessee, Knoxville, Tennessee, USA. LA - eng PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - Female MH - Child MH - *Physical Education and Training/methods MH - Male MH - Adolescent MH - *Exercise/psychology MH - *Wearable Electronic Devices MH - *Vulnerable Populations/psychology MH - Feasibility Studies MH - Digital Health MH - Poverty MH - School Health Services PMC - PMC13509092 OTO - NOTNLM OT - digital health literacy OT - health equity OT - health technology OT - physical activity disparities OT - self-regulation COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/26 CRDT- 2026/08/26 09:22 PHST- 2026/07/08 00:00 [revised] PHST- 2025/12/02 00:00 [received] PHST- 2026/08/08 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 09:22 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - JOSH70219 [pii] AID - 10.1111/josh.70219 [doi] PST - ppublish SO - J Sch Health. 2026 Sep;96(9):e70219. doi: 10.1111/josh.70219. PMID- 42644423 OWN - NLM STAT- Publisher LR - 20260826 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) DP - 2026 Aug 26 TI - Optimizing upper extremity rehabilitation in children with unilateral spastic cerebral palsy: adjunctive strategies and an integrative framework. PG - 1-16 LID - 10.1080/09638288.2026.2719950 [doi] AB - PURPOSE: Intensive, motor learning-based interventions such as constraint-induced movement therapy and bimanual training improve upper extremity outcomes in children with unilateral spastic cerebral palsy, yet required effective dosages are difficult to deliver in clinical settings. This paper conceptualizes how adjunctive strategies may optimize upper extremity rehabilitation by addressing translational constraints. MATERIALS AND METHODS: This perspective integrates selected empirical findings and theory-driven interpretation informed by our experience in pediatric neurorehabilitation and motor learning. Rather than offering a comprehensive review, we use representative evidence to motivate a novel framework and provide pragmatic judgements for clinicians and researchers. RESULTS: Although high-dose, motor learning-based therapies remain the gold standard to improve upper extremity function, implementation is limited by time, cost, and service-delivery constraints. Adjunctive strategies may enhance feasibility through complementary mechanisms: dose modification (e.g., neuromodulation paired with training to enhance responsiveness to practice); and dose distribution (e.g., home-based training, telerehabilitation, and recreational physical activity, which redistribute structured motor practice across varied contexts). Together, these approaches may support sustained practice, motivation, and participation beyond the clinic. CONCLUSION: We propose an integrative framework that positions adjunctive strategies as complements to, rather than replacements for, intensive motor learning-based interventions, supporting upper extremity improvements with fewer clinical hours. FAU - Metelski, Nicole AU - Metelski N AD - Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA. FAU - Gordon, Andrew M AU - Gordon AM AD - Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA. LA - eng PT - Journal Article DEP - 20260826 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM OAB - High-dose, motor learning-based upper extremity therapies remain the gold standard for children with unilateral spastic cerebral palsy, but feasibility is limited by time, cost, and service-delivery constraints.Adjunctive strategies can support upper extremity improvements by enhancing responsiveness to practice or by redistributing practice across settings and schedules.Individual factors, including neurophysiology, age, family capacity, and practice context, should inform selection and integration of adjunctive strategies alongside clinic-based therapy.Distributing motor practice across clinical, home, school, and community contexts may help preserve task-specific, goal-directed practice while reducing reliance on high-dose clinic-based therapy. OABL- eng OTO - NOTNLM OT - Unilateral spastic cerebral palsy OT - home-based training OT - intensive training OT - noninvasive brain stimulation OT - recreational physical activity OT - telerehabilitation OT - therapy dosage OT - upper extremity rehabilitation EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:50 CRDT- 2026/08/26 07:33 PHST- 2026/08/26 11:50 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 07:33 [entrez] AID - 10.1080/09638288.2026.2719950 [doi] PST - aheadofprint SO - Disabil Rehabil. 2026 Aug 26:1-16. doi: 10.1080/09638288.2026.2719950. PMID- 42643926 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260827 IS - 1831-4732 (Electronic) IS - 1831-4732 (Linking) VI - 24 IP - 8 DP - 2026 Aug TI - Modification of the existing maximum residue levels for potassium phosphonates in various crops. PG - e10290 LID - 10.2903/j.efsa.2026.10290 [doi] LID - e10290 AB - In accordance with Article 6 of Regulation (EC) No 396/2005, the applicants DE SANGOSSE S.A.S and Tilco-Alginure submitted a request to the competent national authorities in France and Germany to modify the existing maximum residue levels (MRL) for the active substance potassium phosphonates in banana, pineapples, radish roots and leaves (classified under the subgroup of kales at the time of the MRL application), beans without pods, peas with and without pods and sugar beets. The data submitted in support of the requested uses were found to be sufficient to derive MRL proposals for all crops under assessment except peas with pods. Adequate analytical methods for enforcement are available to control the residues of phosphonic acid in plant matrices, the commodities under consideration at the validated LOQ of 0.1 mg/kg. Based on the risk assessment results, EFSA concluded that the long-term intake of residues resulting from the use of potassium phosphonate according to the reported agricultural practices according to the current ADI of 1 mg/kg bw day is unlikely to present a risk to consumer health. A second assessment using the lower ADI of 0.69 mg/kg bw per day proposed in the peer review of choline hydrogen phosphonate confirmed the exceedances previously identified during the peer review for the Dutch toddler and German children diets. Should the proposed lower ADI be endorsed by risk managers, EFSA recommends a revision of the assessment of the existing MRLs for phosphonic acid and its salts, expressed as phosphonic acid. CI - (c) 2026 European Food Safety Authority. EFSA Journal published by Wiley-VCH GmbH on behalf of European Food Safety Authority. CN - European Food Safety Authority (EFSA) FAU - Bellisai, Giulia AU - Bellisai G FAU - Bernasconi, Giovanni AU - Bernasconi G FAU - Castellan, Irene AU - Castellan I FAU - Del Aguila, Monica AU - Del Aguila M FAU - Ferreira, Lucien AU - Ferreira L FAU - Leuschner, Renata AU - Leuschner R FAU - Mioc, Andrea AU - Mioc A FAU - Szot, Marta AU - Szot M FAU - Tiramani, Manuela AU - Tiramani M FAU - Verani, Alessia AU - Verani A LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - EFSA J JT - EFSA journal. European Food Safety Authority JID - 101642076 PMC - PMC13504444 OTO - NOTNLM OT - MRL OT - consumer risk assessment OT - pesticide OT - phosphonic acid OT - potassium phosphonates OT - various crops EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/25 CRDT- 2026/08/26 06:29 PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 06:29 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - EFS210290 [pii] AID - 10.2903/j.efsa.2026.10290 [doi] PST - epublish SO - EFSA J. 2026 Aug 25;24(8):e10290. doi: 10.2903/j.efsa.2026.10290. eCollection 2026 Aug. PMID- 42643824 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260827 IS - 2383-1219 (Electronic) IS - 2345-5152 (Print) IS - 2345-5152 (Linking) VI - 13 IP - 3 DP - 2026 Jul TI - The Correlations between Spatial Equality and School Environment with Children's Physical Activity Levels: The Mediating Role of Motivation toward Physical Education. PG - 196-204 LID - 10.30476/intjsh.2026.109473.1592 [doi] AB - BACKGROUND: Children's engagement in physical activity (PA) is influenced by a combination of environmental and psychological factors. The present study aimed to investigate the correlation of spatial equality and the school environment with children's PA levels, given the mediating role of motivation toward physical education (PE). METHODS: A cross-sectional survey was conducted in 2024 in Gorgan, Iran, involving 384 middle-school students (mean age=13.1+/-0.9 years; 194 (50.5%) female and 190 (49.5%) male students). The study participants completed validated questionnaires assessing spatial equality (NEWS-Y), the school environment (SPAEQ), motivation for PE (PEMS), and PA levels (PAQ-C). Structural equation modeling (SEM) was used to investigate both direct and indirect correlations between the variables of the study. RESULTS: Boys exhibited significantly higher levels of PA (M=3.38+/-0.70) compared with girls (M=3.18+/-0.73; P=0.012). Both spatial equality and the school environment were positively correlated with motivation for PE (r=0.62, P<0.001; r=0.59, P<0.001, respectively) and with PA (r=0.48, P<0.001; r=0.51, P<0.001, respectively). SEM results revealed significant correlations of spatial equality (beta=0.14, P=0.005) and the school environment (beta=0.18, P<0.001) with PA, with motivation toward PE acting as a partial mediator (indirect beta=0.15-0.22, P<0.001). CONCLUSIONS: The study results underscored the importance of comprehensive school interventions that integrate equitable infrastructure aimed at enhancing student motivation, thereby encouraging the development of lifelong habits of PA. CI - Copyright: (c) International Journal of School Health. FAU - Monadi, Aref AU - Monadi A AD - Department of Urban Engineering, Faculty of Architecture and Urban Design, Sooreh International University, Tehran, Iran. FAU - Dana, Amir AU - Dana A AD - Department of Physical Education, Ta.C, Islamic Azad University, Tabriz, Iran. FAU - Ghorbani, Saeed AU - Ghorbani S AD - Department of Physical Education, Isl.C., Islamic Azad University, Islamshahr, Iran. LA - eng PT - Journal Article DEP - 20260701 PL - Iran TA - Int J Sch Health JT - International journal of school health JID - 101702483 PMC - PMC13504179 OTO - NOTNLM OT - Environment OT - Exercise OT - Motivation OT - Schools OT - Spatial Equality COIS- None declared. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/07/01 CRDT- 2026/08/26 06:18 PHST- 2025/11/02 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2026/01/04 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 06:18 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - intjsh-13-3 [pii] AID - 10.30476/intjsh.2026.109473.1592 [doi] PST - epublish SO - Int J Sch Health. 2026 Jul 1;13(3):196-204. doi: 10.30476/intjsh.2026.109473.1592. eCollection 2026 Jul. PMID- 42643582 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260827 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Pulmonary function and risk factors in pediatric chest tightness variant asthma: a case-control study. PG - 1842381 LID - 10.3389/fped.2026.1842381 [doi] LID - 1842381 AB - OBJECTIVE: To investigate the pulmonary function characteristics and risk factors for pediatric chest tightness variant asthma (CTVA). METHODS: A retrospective case-control study was conducted. Clinical data of 39 children diagnosed with CTVA in our outpatient department from February 2022 to February 2024 were analyzed. Fifty healthy children undergoing physical examinations during the same period were enrolled as controls. All participants underwent fractional exhaled nitric oxide (FeNO) measurement and pulmonary ventilation function tests at initial diagnosis or physical examination. FeNO levels and pulmonary function parameters were compared between groups. Baseline demographic and clinical data were recorded. Univariate logistic regression analyses were performed to explore factors associated with pediatric CTVA. Due to the limited sample size (39 cases) and an event-per-variable ratio below the recommended minimum of 10:1 for reliable multivariable modeling, multivariate analysis was not performed. RESULTS: FeNO levels were significantly higher in the CTVA group than in the healthy control group (p = 0.016). FEV1/FVC, PEF, FEF25, FEF50, and FEF75 were significantly lower in the CTVA group (all p < 0.05), whereas FEV1, FVC, and MMEF showed no significant differences (p > 0.05). Significant intergroup differences were observed for obesity, inhalant allergen sensitization, allergic rhinitis, atopic dermatitis, history of recurrent respiratory infections, and family history of allergic diseases (all p < 0.05). Univariate logistic regression analysis confirmed these six factors as significantly associated with pediatric CTVA (all p < 0.05).ntified these six factors as potential independent risk factors for pediatric CTVA (all p < 0.05). CONCLUSION: Children with CTVA have higher FeNO levels and lower FEV1/FVC, PEF, FEF25, FEF50, and FEF75 compared to healthy peers. Obesity, inhalant allergens, allergic rhinitis, atopic dermatitis, recurrent respiratory infections, and family history of allergic diseases showed significant univariate associations with pediatric CTVA in this exploratory cohort. Combined assessment of FeNO and small airway parameters may aid in the diagnostic evaluation of CTVA, although further diagnostic accuracy studies are needed. CI - (c) 2026 Cao, He, Yu and Tong. FAU - Cao, Ruo-Yu AU - Cao RY AD - Department of Pediatrics, Cangzhou Central Hospital, Cangzhou, Hebei, China. FAU - He, Wei-Chao AU - He WC AD - Department of Pediatrics, Cangzhou Central Hospital, Cangzhou, Hebei, China. FAU - Yu, Ya-Bin AU - Yu YB AD - Department of Pediatrics, Hejian City Hospital of TCM, Cangzhou Central Hospital Medical Group, Hejian City, Hebei, China. FAU - Tong, Shan-Shan AU - Tong SS AD - Department of Pediatrics, Cangzhou Central Hospital, Cangzhou, Hebei, China. LA - eng PT - Journal Article DEP - 20260811 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13503571 OTO - NOTNLM OT - chest tightness variant asthma OT - children OT - fractional exhaled nitric oxide (FENO) OT - pulmonary function OT - risk factors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/11 CRDT- 2026/08/26 05:49 PHST- 2026/03/30 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 05:49 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 10.3389/fped.2026.1842381 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 11;14:1842381. doi: 10.3389/fped.2026.1842381. eCollection 2026. PMID- 42643513 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260827 IS - 2755-0834 (Electronic) IS - 2755-0834 (Linking) VI - 10 DP - 2026 Jan-Dec TI - Prevalence of anemia and years lived with disability in eastern Sub-Saharan Africa, 1990 to 2023. PG - 27550834261483633 LID - 10.1177/27550834261483633 [doi] LID - 27550834261483633 AB - BACKGROUND: Anemia remains a significant public health challenge in the Eastern Sub-Saharan Africa region, contributing to substantial morbidity and adverse outcomes across the lifespan. Understanding trends in the prevalence anemia due to all causes and the years lived with disability is critical for informing targeted interventions and strengthening health systems in the region. METHODS: This study followed the methodological framework of the Global Burden of Disease 2023 study to estimate the prevalence of anemia and the years lived with disability in the Eastern Sub-Saharan African region from 1990 to 2023. Data were synthesized from a broad range of sources, including population-based surveys, antenatal clinic records, hospital registries, and demographic surveillance systems. Bayesian meta-regression tool for disease modeling (DisMod-MR 2.1) was used to estimate prevalence and years lived with disability. Estimates were stratified by age, sex, and locations, ensuring internal consistency over time and across subpopulations. All estimates were reported with 95% uncertainty intervals. RESULTS: The age-standardized prevalence of anemia due to all causes was estimated to be 38,264 cases per 100,000 population (95% UI: 32,886-46,273), and the age-standardized years lived with disability was 1,247 years lived with disability per 100,000 population (95% UI: 787-2,015). Mild anemia (19.9% (95% UI: 15.6-27.3)) and moderate anemia (16.7% (95% UI: 13.5-20.2)) contributed higher share of the prevalence, whereas moderate anemia contributed the most for the years lived with disability (7% (95% UI: 5.4-9.3)). CONCLUSION: This study has underscores that the prevalence of anemia due to all causes and the years lived with disability were high in the Eastern Sub-Saharan African region, with under-five children disproportionately affected and stagnant trend over the past three decades. Strengthening nutrition programs, improving access to healthcare services, and implementing context-specific strategies are critical to accelerating progress toward anemia reduction in the region. CI - (c) The Author(s) 2026. FAU - Tadesse, Sebsibe AU - Tadesse S AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 AD - National Data Management and Analytics Center for Health, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Aliyo, Alqeer AU - Aliyo A AUID- ORCID: 0000-0001-7301-5332 AD - Department of Medical Laboratory Science, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Gebremeskel Ftwi, Fre AU - Gebremeskel Ftwi F AD - Department of Nutrition and Health System, School of Public Health, College of Medicine and Health Sciences, Adgirat University, Adigrat, Ethiopia. FAU - Gezae, Kebede Embaye AU - Gezae KE AD - Faculty of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. RINGGOLD: 128165 FAU - Ashenafi, Girma AU - Ashenafi G AD - Department of Medical Laboratory Science, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Beyene, Belda Negesa AU - Beyene BN AUID- ORCID: 0000-0002-0586-0080 AD - Department of Midwifery, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Fikrie, Anteneh AU - Fikrie A AUID- ORCID: 0000-0002-9809-3326 AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 LA - eng PT - Journal Article DEP - 20260824 PL - United States TA - J Med Access JT - The journal of medicine access JID - 9918367185906676 PMC - PMC13504108 OAB - Anemia, characterized by severe fatigue and weakness resulting from a deficiency of healthy red blood cells, remains a critical public health crisis in East Africa, disproportionately affecting young children. We evaluated regional health data spanning 1990 to 2023 to assess anemia prevalence, its functional impact on daily life, and the demographic groups most severely affected. Regional progress has entirely stagnated. Anemia prevalence in 2023 mirrored 1990 levels, impacting approximately 38% of the population. Although mild cases predominate, moderate anemia accounts for the greatest burden of physical exhaustion, with children under five remaining the most vulnerable demographic. Three decades of public health interventions have failed to reduce anemia in the region. Breaking this persistent cycle requires governments to urgently scale up targeted nutritional programs and strengthen basic healthcare access for vulnerable households. OABL- eng OTO - NOTNLM OT - anemia OT - burden OT - global burden of diseases OT - prevalence OT - types of anemia OT - under-five children OT - years lived with disability COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/24 CRDT- 2026/08/26 05:40 PHST- 2026/06/16 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 05:40 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.1177_27550834261483633 [pii] AID - 10.1177/27550834261483633 [doi] PST - epublish SO - J Med Access. 2026 Aug 24;10:27550834261483633. doi: 10.1177/27550834261483633. eCollection 2026 Jan-Dec. PMID- 42643340 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260827 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Identifying critical windows for macrosomia prevention: a study on the association between phase-specific dynamic BMI changes and macrosomia risk. PG - 1875915 LID - 10.3389/fendo.2026.1875915 [doi] LID - 1875915 AB - OBJECTIVE: To examine the correlation among pre-pregnancy body mass index (BMI), BMI increments during different gestational periods, and the occurrence of macrosomia in singleton full-term pregnant women without complications. Additionally, we aimed to assess the predictive performance of these BMI-related indicators for macrosomia, thereby identifying key time windows for targeted gestational weight management. METHODS: An analytical approach was adopted, entailing a retrospective evaluation of clinical data from 4,218 pregnant women without complications who underwent regular prenatal examinations and singleton full-term delivery during the period between January 2019 and December 2025 at the Jinshan Branch of Shanghai Sixth People's Hospital. Based on neonatal birth weight, a case-control design was employed, selecting 200 cases of macrosomia (macrosomia group) and 250 cases of normal birth weight infants (control group). Data including pre-pregnancy BMI, baseline BMI at the first prenatal visit (10-13 weeks), and BMI at various stages of mid- and late-pregnancy (20, 24, 28, 32, 36 weeks, and before delivery) were collected to calculate BMI increments for each stage. The predictive efficacy of individual BMI indicators and a combined model for macrosomia was evaluated using independent sample t-tests, Pearson correlation analysis (PCA), and receiver operating characteristic (ROC) curves. RESULTS: (1) Increased pre-pregnancy BMI was significantly and positively correlated with an increased macrosomia risk. Pre-pregnancy overweight (OR = 2.63) and obesity (OR = 9.06) emerged as independent risk contributors for macrosomia (P < 0.01). (2) Baseline BMI at 10-13 weeks, along with BMI increments during the 32-36 weeks period and the period from 36 weeks to delivery, exhibited a significant increase in the macrosomia group in comparison to the control group (P < 0.05). (3) The analysis of correlation demonstrated a moderate positive correlation between baseline BMI at 10-13 weeks and neonatal birth weight (r = 0.386, P < 0.001). However, no significant correlation was identified between mid-pregnancy BMI increments and birth weight (P > 0.05). (4) Utilising ROC curve analysis, it was ascertained that baseline BMI at 10-13 weeks exhibited the most optimal predictive efficacy among the individual indicators (AUC = 0.73), with the late-pregnancy increment indicators following in succession. The combined predictive model, integrating early-pregnancy BMI and late-pregnancy BMI increments, achieved a superior AUC of 0.84. CONCLUSION: Pre-pregnancy BMI, early-pregnancy (10-13 weeks) BMI, and late-pregnancy (32 weeks to delivery) BMI increments are critical predictors of macrosomia in pregnant women without complications. Specifically, baseline BMI at 10-13 weeks serves as a core indicator for early risk identification. Clinical interventions should focus on these two critical stages-early and late pregnancy-to implement individualized weight management, thereby effectively reducing the incidence of macrosomia and improving maternal and neonatal outcomes. CI - Copyright (c) 2026 Qu and Zhou. FAU - Qu, Huiling AU - Qu H AD - Department of Obstetrics and Gynecology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, China. FAU - Zhou, Yanna AU - Zhou Y AD - Department of Obstetrics and Gynecology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, China. LA - eng PT - Journal Article DEP - 20260811 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Female MH - *Fetal Macrosomia/prevention & control/epidemiology/etiology MH - Pregnancy MH - *Body Mass Index MH - Retrospective Studies MH - Adult MH - Case-Control Studies MH - Birth Weight MH - Risk Factors MH - Infant, Newborn MH - China/epidemiology MH - *Gestational Weight Gain MH - Gestational Age PMC - PMC13503171 OTO - NOTNLM OT - BMI increment OT - gestational BMI OT - macrosomia OT - pre-pregnancy body mass index (BMI) OT - pregnancy outcomes OT - weight management COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/11 CRDT- 2026/08/26 05:09 PHST- 2026/05/08 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 05:09 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 10.3389/fendo.2026.1875915 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 11;17:1875915. doi: 10.3389/fendo.2026.1875915. eCollection 2026. PMID- 42643055 OWN - NLM STAT- Publisher LR - 20260826 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) DP - 2026 Aug 26 TI - Parents'/Caregivers' perspectives on weight management in children with cystic fibrosis receiving modulator therapy: A cross-sectional survey. LID - 10.1002/ncp.70173 [doi] AB - BACKGROUND: Modulator therapy in children with cystic fibrosis (cwCF) has improved lung function and digestive health, prompting changes in nutrition management strategies for many cwCF. The purpose of this study is to describe parents'/caregivers' perspectives on weight management in cwCF with the introduction of cystic fibrosis transmembrane conductance regulator modulator therapies (CFTRm). METHODS: Researchers developed a cross-sectional survey regarding parents'/caregivers' perceptions of weight management in cwCF. Content validity was established through four expert reviews and two cognitive interviews. A link to the survey was posted on two private Facebook pages with members who attended a CF clinic in the western United States and distributed to families attending a CF clinic in the southeastern United States. Survey responses were analyzed with descriptive statistics. RESULTS: Forty-nine parents/caregivers represented data for 60 cwCF. Sixty cwCF were prescribed CFTRm, and 46 (76.6%) had taken CFTRm for more than a year. Forty-nine (86%) parents/caregivers agreed with clinicians on the weight classification of their cwCF. Many (52%) cwCF who received CFTRm for more than a year made changes to their diet. Parents/caregivers reported a mean score of 8.31 +/- 2.47, with 10 being very comfortable talking with the clinic about their child's weight. CONCLUSION: Parents'/caregivers' perceptions of weight management in their cwCF varied. Nutrition strategy changes ranged from adding additional calories to decreasing calories and discontinuing supplemental nutrition after starting CFTRm. Individualized nutrition therapy is required in the era of CFTRm. Parents'/caregivers' concerns and perspectives about weight and diet are vital to assessing weight management. CI - (c) 2026 American Society for Parenteral and Enteral Nutrition. FAU - Bellini, Sarah Gunnell AU - Bellini SG AUID- ORCID: 0000-0002-6755-6201 AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, Provo, Utah, USA. FAU - Keiser, Kayla AU - Keiser K AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, Provo, Utah, USA. FAU - Christenson, Makenzie AU - Christenson M AD - Clinical Nutrition Department and Cystic Fibrosis Center, Arkansas Children's Northwest, Springdale, Arkansas, USA. FAU - Coe, TrudyAnne AU - Coe T AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, Provo, Utah, USA. FAU - McDonald, Catherine M AU - McDonald CM AUID- ORCID: 0000-0003-3467-4663 AD - Primary Children's Hospital, Salt Lake City, Utah, USA. FAU - McRoberts, Madison AU - McRoberts M AD - Primary Children's Hospital, Salt Lake City, Utah, USA. FAU - Stoker, Jenna AU - Stoker J AD - Primary Children's Hospital, Salt Lake City, Utah, USA. LA - eng GR - This study was funded by Brigham Young University College of Life Sciences Grant./ PT - Journal Article DEP - 20260826 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM OTO - NOTNLM OT - CFTR modulators OT - children OT - cystic fibrosis OT - disordered eating OT - nutrition management OT - weight management EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:36 CRDT- 2026/08/26 03:22 PHST- 2026/07/28 00:00 [revised] PHST- 2026/02/13 00:00 [received] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/08/26 05:36 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/26 03:22 [entrez] AID - 10.1002/ncp.70173 [doi] PST - aheadofprint SO - Nutr Clin Pract. 2026 Aug 26. doi: 10.1002/ncp.70173. PMID- 42642965 OWN - NLM STAT- Publisher LR - 20260826 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Aug 25 TI - Growth and survival of spore forming Bacillus cereus in human milk exposed to different processing, and storage conditions. LID - 10.1002/jpn3.70548 [doi] AB - OBJECTIVES: Human milk (HM) is the preferred nutrition for all infants, including preterm and low-birth-weight infants, but it may still pose infectious risks even after pasteurization. Data on the behavior of Bacillus cereus in HM are limited. We therefore investigated the growth and survival of B. cereus in defrosted HM under processing and storage conditions typical of neonatal intensive care unit practice, in vitro. METHODS: Frozen HM from five mothers was thawed, pooled, and screened for baseline contamination, then inoculated with a clinical B. cereus isolate (~1.5 x 10(5) CFU/mL). Samples were allocated to three groups: (A) native HM warmed to 37 degrees C for 3 h; (B) pasteurized HM subsequently warmed to 37 degrees C; and (C) pasteurized HM stored frozen (-21 degrees C for 1 week), thawed, and then warmed to 37 degrees C. B. cereus growth and survival were assessed at 0.5, 1, 2, and 3 h. RESULTS: Standard pasteurization did not eradicate B. cereus, achieving only a 1-log reduction in CFU/mL. Subsequent warming to 37 degrees C permitted rapid regrowth, with counts returning to the initial inoculum (~1 x 10(5) CFU/mL) after 3 h. Pasteurization followed by freezing did not further reduce bacterial counts but effectively inhibited proliferation, maintaining lower levels (~1 x 10(4) CFU/mL) during subsequent warming. CONCLUSIONS: HM should be fed as soon as it reaches feeding temperature and preferably within 1 h. When immediate feeding is not feasible, freezing HM after pasteurization is advisable to inhibit B. cereus growth. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Gsollpointner, Melanie AU - Gsollpointner M AUID- ORCID: 0000-0002-5832-7810 AD - Department of Neonatology, Kepler University Hospital, Johannes Kepler University, Linz, Austria. FAU - Haiden, Nadja AU - Haiden N AUID- ORCID: 0000-0003-4806-0312 AD - Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. FAU - Eberl, Sabine AU - Eberl S AD - Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. FAU - Zeitlinger, Markus AU - Zeitlinger M AD - Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. FAU - Nussbaumer-Proll, Alina AU - Nussbaumer-Proll A AD - Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. LA - eng GR - None/ PT - Journal Article DEP - 20260825 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - freezing OT - human milk bank OT - pasteurization OT - preterm infants EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:36 CRDT- 2026/08/26 01:53 PHST- 2026/06/29 00:00 [revised] PHST- 2026/02/15 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/26 05:36 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/26 01:53 [entrez] AID - 10.1002/jpn3.70548 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Aug 25. doi: 10.1002/jpn3.70548. PMID- 42642883 OWN - NLM STAT- Publisher LR - 20260907 IS - 2151-4658 (Electronic) IS - 2151-464X (Linking) DP - 2026 Aug 25 TI - Validation of Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Measures for Children With Chronic Nonbacterial Osteomyelitis. LID - 10.1002/acr.80146 [doi] AB - OBJECTIVE: To assess the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in patients with chronic nonbacterial osteomyelitis (CNO). METHODS: Within the longitudinal patient registry of CNO, English-speaking patients aged 8 years and older self-reported PROMIS Pediatric measures of fatigue, pain interference (PI), pain behavior (PB), mobility, upper extremity (UE), physical activity (PA), and strength impact (SI), and external validation measures. Log-transformed linear mixed-effects models with random patient intercepts were used to assess PROMIS T-score changes. Wilcoxon signed-rank test was performed to determine the PROMIS T-score changes among the improved, worsened, and unchanged groups. Spearman rank correlation test determined the relationship of PROMIS T-scores with disease status reported by patients/families. RESULTS: More than 1,000 clinical visits from 184 patients included PROMIS Pediatric measures entries. All PROMIS T-scores correlated significantly (P < 0.01) with patient-reported variables and physician global assessment (PHGA). The correlation between function and mobility, PB, and PI was good (r = 0.4-0.6). The correlation of patient-reported disease status was strong with PHGA (r = 0.75); moderate with mobility, PB, and PI; and weak with fatigue, SI, UE, and PA. The changes of PROMIS T-scores over time for mobility, PB, PA, and PI compared with the self-reported status change were significant (P < 0.05). After effective treatment, when clinical disease activity score improved by at least three points (n = 18), the change of PROMIS T-scores for mobility, PB, PI, and UE were significant (P < 0.05). CONCLUSION: This study provided evidence supporting the use of PROMIS Pediatric mobility, PB, and PI measures for CNO clinical disease monitoring. CI - (c) 2026 The Author(s). Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology. FAU - Eckert, Mary M AU - Eckert MM AUID- ORCID: 0009-0000-2105-5025 AD - Western University of Health Sciences, Lebanon, Oregon. AD - Seattle Children's Hospital, Seattle, Washington. FAU - Wu, Eveline Y AU - Wu EY AUID- ORCID: 0000-0002-6394-6843 AD - The University of North Carolina at Chapel Hill. FAU - Oliver, Melissa AU - Oliver M AUID- ORCID: 0000-0002-7689-2573 AD - Indiana University School of Medicine, Indianapolis. FAU - Scheck, Joshua AU - Scheck J AD - Seattle Children's Hospital, Seattle, Washington. FAU - Lapidus, Sivia AU - Lapidus S AUID- ORCID: 0000-0001-8452-9937 AD - Joseph M. Sanzari Children's Hospital, Hackensack, New Jersey. AD - Hackensack University Medical Center, Hackensack, New Jersey. AD - Hackensack Meridian School of Medicine, Hackensack, New Jersey. FAU - Akca, Ummusen Kaya AU - Akca UK AUID- ORCID: 0000-0002-0426-9432 AD - Hacettepe University, Pediatric Rheumatology, Ankara, Turkey. FAU - Yasin, Shima AU - Yasin S AD - University of Iowa Carver College of Medicine, Iowa City. FAU - Lenert, Aleksander AU - Lenert A AUID- ORCID: 0000-0003-2129-3263 AD - University of Iowa Carver College of Medicine, Iowa City. FAU - Stern, Sara AU - Stern S AD - University of Utah, Salt Lake City. FAU - Insalaco, Antonella AU - Insalaco A AD - IRCCS Ospedale Pediatrico Bambino Gesu, Rheumatology, Rome, Italy. AD - ERN RITA Center, Rheumatology, Rome, Italy. FAU - Pardeo, Manuela AU - Pardeo M AUID- ORCID: 0000-0003-0850-7351 AD - IRCCS Ospedale Pediatrico Bambino Gesu, Rheumatology, Rome, Italy. AD - ERN RITA Center, Rheumatology, Rome, Italy. FAU - Simonini, Gabriele AU - Simonini G AD - AOU Meyer Children's Hospital, Rheumatology, Florence, Italy. AD - ERN ReCONNET Center, Rheumatology, Florence, Italy. FAU - Marrani, Edoardo AU - Marrani E AD - AOU Meyer Children's Hospital, Rheumatology, Florence, Italy. FAU - Wang, Xing AU - Wang X AD - Seattle Children's Research Institute, Seattle, Washington. FAU - Huang, Bin AU - Huang B AUID- ORCID: 0000-0001-9724-675X AD - Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio. FAU - Kovalick, Leonard K AU - Kovalick LK AD - The University of North Carolina at Chapel Hill. FAU - Rosenwasser, Natalie AU - Rosenwasser N AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Balay-Destrude, Erin AU - Balay-Destrude E AUID- ORCID: 0000-0001-6235-1947 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Casselman, Gabriel AU - Casselman G AUID- ORCID: 0000-0001-6950-7502 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Liau, Adriel AU - Liau A AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Klein, Ava AU - Klein A AD - Seattle Children's Hospital, Seattle, Washington. FAU - Shao, Yurong AU - Shao Y AD - Seattle Children's Hospital, Seattle, Washington. FAU - Yang, Claire AU - Yang C AUID- ORCID: 0000-0001-6822-0518 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Briggs, Molly AU - Briggs M AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Mueller, Ethan AU - Mueller E AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Deng, Emily AU - Deng E AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Trunnell, Paige Rhiannon AU - Trunnell PR AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Hamilton, Iris AU - Hamilton I AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Machrone, Elise AU - Machrone E AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Mosa, Doaa Mosad AU - Mosa DM AD - Mansoura University Hospitals, Rheumatology, Rehabilitation, Mansoura, Egypt. AD - Mansoura University, Rheumatology, Rehabilitation, Mansoura, Egypt. FAU - Tucker, Lori AU - Tucker L AUID- ORCID: 0000-0002-4314-6750 AD - BC Children's Hospital, Rheumatology, Vancouver, British Columbia, Canada. AD - University of British Columbia, Rheumatology, Vancouver, British Columbia, Canada. FAU - Girschick, Hermann AU - Girschick H AUID- ORCID: 0000-0002-2755-3129 AD - Vivantes Clinic Friedrichshain, Pediatrics, Berlin, Germany. FAU - Laxer, Ronald M AU - Laxer RM AD - The Hospital for Sick Children, Toronto, Ontario, Canada. AD - University of Toronto, Toronto, Ontario, Canada. AD - St Michael's Hospital, Toronto, Ontario, Canada. FAU - Tiller, Georgina AU - Tiller G AD - Royal Children's Hospital, Pediatrics, Melbourne, Victoria, Australia. FAU - Akikusa, Jonathan AU - Akikusa J AD - Royal Children's Hospital, Pediatrics, Melbourne, Victoria, Australia. FAU - Hedrich, Christian M AU - Hedrich CM AUID- ORCID: 0000-0002-1295-6179 AD - Alder Hey Children's NHS Foundation Trust, Department of Pediatric Rheumatology, Liverpool, United Kingdom. AD - Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom. FAU - Onel, Karen AU - Onel K AUID- ORCID: 0000-0002-1238-5361 AD - Hospital for Special Surgery, New York, New York. FAU - Dedeoglu, Fatma AU - Dedeoglu F AUID- ORCID: 0000-0002-7516-0848 AD - Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Twilt, Marinka AU - Twilt M AUID- ORCID: 0000-0003-1954-2822 AD - Department of Pediatrics, Section of Rheumatology, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Ozen, Seza AU - Ozen S AUID- ORCID: 0000-0003-2883-7868 AD - Hacettepe University, Pediatric Rheumatology, Ankara, Turkey. FAU - Ferguson, Polly J AU - Ferguson PJ AD - University of Iowa Carver College of Medicine, Iowa City. FAU - Schanberg, Laura AU - Schanberg L AUID- ORCID: 0000-0002-1913-6472 AD - Duke Clinical Research Institute, Durham, North Carolina. AD - Duke University School of Medicine, Durham, North Carolina. FAU - Reeve, Bryce B AU - Reeve BB AUID- ORCID: 0000-0002-6709-8714 AD - Duke Clinical Research Institute, Durham, North Carolina. AD - Duke University School of Medicine, Durham, North Carolina. FAU - Zhao, Yongdong AU - Zhao Y AUID- ORCID: 0000-0003-3618-1379 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. LA - eng GR - Kaila Komfort/ PT - Journal Article DEP - 20260825 PL - United States TA - Arthritis Care Res (Hoboken) JT - Arthritis care & research JID - 101518086 SB - IM EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:36 CRDT- 2026/08/26 01:02 PHST- 2026/07/27 00:00 [revised] PHST- 2025/11/20 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/26 05:36 [medline] PHST- 2026/08/26 01:02 [entrez] AID - 10.1002/acr.80146 [doi] PST - aheadofprint SO - Arthritis Care Res (Hoboken). 2026 Aug 25. doi: 10.1002/acr.80146. PMID- 42642695 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260924 IS - 1996-9805 (Electronic) IS - 1818-6300 (Print) IS - 1818-6300 (Linking) VI - 27 IP - 5 DP - 2026 Oct TI - Dental erosion and erosive tooth wear in childhood and adolescence: from diagnosis to prevention. PG - 1317-1333 LID - 10.1007/s40368-026-01233-8 [doi] AB - BACKGROUND: Dental erosion and erosive tooth wear (ETW) are increasingly significant non-carious defects in industrialized countries. Reasons for an increased prevalence are mainly modern dietary habits, but an improved diagnostic awareness also contributes to an apparent increase in cases. Unlike caries, erosion involves acid-induced demineralization without bacterial involvement. When this is combined with mechanical wear, it results in ETW. Diagnosis commonly employs the Basic Erosive Wear Examination (BEWE), a standardized clinical index assessing lesion severity across sextants. ETIOLOGY AND SUSCEPTIBILITY FACTORS: Primary teeth might be more susceptible to ETW due to thinner and less mineralized enamel with lower microhardness, and dentine with a higher carbonate content and higher tubule density. Longer acid exposures increase their demineralization rates compared to permanent teeth. The salivary pellicle offers variable protection, with children's saliva showing distinct composition and efficacy. Key risk factors include frequent consumption of acidic beverages, certain medications, gastroesophageal reflux, and certain behavioral habits. Genetic, salivary, and lifestyle factors further modulate individual susceptibility. PREVENTION: Preventive strategies emphasize risk assessment, dietary modification, and chemical protection using different fluoride-based agents, which form acid-resistant surface layers reducing enamel and dentine solubility. Combinations with chitosan or other polymers may enhance protection. Novel approaches include bio-inspired and film-forming agents, pellicle modification with proteins (e.g., CaneCPI-5), and natural polyphenols that reinforce acid resistance and collagen stability. While laboratory and in situ studies support these strategies, long-term clinical validation remains limited. CONCLUSIONS: Comprehensive management of ETW should integrate early diagnosis, patient education, and multi-modal prevention, particularly targeting children and adolescents, where susceptibility and long-term consequences are greatest. CI - (c) 2026. The Author(s). FAU - Carvalho, T S AU - Carvalho TS AD - School of Dental Medicine, Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland. FAU - Baumann, T AU - Baumann T AD - School of Dental Medicine, Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland. tommy.baumann@unibe.ch. FAU - Niemeyer, S H AU - Niemeyer SH AD - School of Dental Medicine, Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland. FAU - Buzalaf, M A R AU - Buzalaf MAR AD - Bauru School of Dentistry, University of Sao Paulo, Bauru, Brazil. FAU - Lingstrom, P AU - Lingstrom P AD - Institute of Odontology, Department of Cariology, University of Gothenburg, Gothenburg, Sweden. FAU - Lussi, A AU - Lussi A AD - School of Dental Medicine, Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland. AD - University Hospital for Conservative Dentistry and Periodontology, Medical University of Innsbruck, Innsbruck, Austria. AD - University Medical Centre, Department of Operative Dentistry and Periodontology, University of Freiburg, Freiburg, Germany. LA - eng PT - Journal Article PT - Review DEP - 20260825 PL - England TA - Eur Arch Paediatr Dent JT - European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry JID - 101277157 SB - IM MH - Humans MH - *Tooth Erosion/diagnosis/prevention & control/etiology MH - Child MH - Adolescent MH - Risk Factors MH - *Tooth Wear/prevention & control/diagnosis/etiology MH - Fluoride Treatment PMC - PMC13593698 OTO - NOTNLM OT - Adolescence OT - Childhood OT - Erosion OT - Erosive tooth wear OT - Prevention COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2026/08/26 05:36 MHDA- 2026/09/21 17:47 PMCR- 2026/08/25 CRDT- 2026/08/26 00:14 PHST- 2025/12/16 00:00 [received] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/26 00:14 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.1007/s40368-026-01233-8 [pii] AID - 1233 [pii] AID - 10.1007/s40368-026-01233-8 [doi] PST - ppublish SO - Eur Arch Paediatr Dent. 2026 Oct;27(5):1317-1333. doi: 10.1007/s40368-026-01233-8. Epub 2026 Aug 25. PMID- 42642511 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Aug 25 TI - The relationship between problematic media use and their fear, anxiety and behavior during dental treatment in children. LID - 10.1038/s41598-026-63546-4 [doi] LID - 26663 AB - This study aimed to investigate individual, familial, and media-related factors associated with dental fear and anxiety (DFA) and dental behavior management problems (DBMP) in school-age children, with particular emphasis on problematic media use (PMU). In this cross-sectional study, 145 children aged 6-12 years undergoing restorative dental treatment were evaluated. Sociodemographic characteristics, maternal dental anxiety, children's media use characteristics, and PMU were assessed using parental questionnaires and the Problematic Media Use Measure-Short Form (PMUM-SF). Children's dental fear and anxiety were assessed using validated child questionnaires, namely the Children's Fear Survey Schedule-Dental Subscale (CFSS-DS) and the Modified Child Dental Anxiety Scale (MCDASf), while behavior during dental treatment was assessed using the standardized Frankl Rating Scale (FRS). Group comparisons, correlation analyses, and multivariable logistic regression analyses were performed. Dental anxiety and uncooperative behavior during dental treatment were more common among early school-age children than pre-teens (p = 0.011 and p = 0.002, respectively). Maternal dental anxiety was independently associated with uncooperative behavior during dental treatment (AOR = 2.93, 95% CI:1.36-6.30) and dental fear (AOR = 2.86, 95% CI:1.38-5.94). PMUM-SF scores did not differ significantly between children with and without dental anxiety in unadjusted analyses. However, after adjustment for potential confounders, higher PMUM-SF scores were independently associated with dental fear (AOR = 1.07, 95% CI:1.01-1.13). The observed correlations between PMUM-SF scores and dental anxiety-related measures were statistically significant but weak. Younger age and maternal dental anxiety were among the factors most consistently associated with children's dental fear and behavior. Although PMU showed only weak associations with dental anxiety-related outcomes, higher PMUM-SF scores were independently associated with dental fear after adjustment for potential confounders. These findings should be interpreted cautiously and considered exploratory given the cross-sectional design and modest effect sizes. CI - (c) 2026. The Author(s). FAU - Mustuloglu, Seyma AU - Mustuloglu S AUID- ORCID: 0000-0001-9796-4348 AD - Department of Paediatric Dentistry, Faculty of Dentistry, Mersin University, Mersin, Turkey. dtseymaozturk@gmail.com. FAU - Tezol, Ozlem AU - Tezol O AUID- ORCID: 0000-0001-9994-7832 AD - Department of Pediatrics, Faculty of Medicine, Mersin University, Mersin, Turkey. FAU - Yalcin, Siddika Songul AU - Yalcin SS AUID- ORCID: 0000-0001-9061-4281 AD - Department of Social Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260825 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Female MH - *Dental Anxiety/psychology/epidemiology MH - Male MH - Cross-Sectional Studies MH - *Child Behavior/psychology MH - Surveys and Questionnaires MH - Media Exposure PMC - PMC13507237 OTO - NOTNLM OT - Behavior Management Problems OT - Children OT - Dental Fear and Anxiety OT - Problematic Media Use OT - Screen Time COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Mersin University Non-Interventional Clinical Research Ethics Committee's (2022/740) approval was obtained. EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:37 PMCR- 2026/08/25 CRDT- 2026/08/25 23:56 PHST- 2026/04/02 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/26 05:37 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/25 23:56 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.1038/s41598-026-63546-4 [pii] AID - 63546 [pii] AID - 10.1038/s41598-026-63546-4 [doi] PST - epublish SO - Sci Rep. 2026 Aug 25;16(1):26663. doi: 10.1038/s41598-026-63546-4. PMID- 42642465 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Aug 25 TI - Prevalence of attention-deficit/hyperactivity disorder symptoms and associated factors among university students in Egypt: a cross-sectional study. LID - 10.1038/s41598-026-63835-y [doi] LID - 26653 AB - Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder that persists in adulthood, affecting academic performance and daily functioning. Despite its significance, limited research has explored the prevalence of ADHD-like symptoms among university students in Egypt. This study aims to estimate the prevalence of ADHD Symptoms among Egyptian university students and identify associated factors. A cross-sectional study was conducted using an online self-administered questionnaire among students aged >/= 18 years or older from various Egyptian universities. The Adult ADHD Self-Report Scale (ASRS) was used to assess ADHD symptoms. A non-probability convenience sampling technique was applied, and multivariable logistic regression was performed to determine associated risks of ADHD positivity. A total of 3,136 responses were collected, with 2,383 valid responses included in the final analysis. The estimated prevalence of ADHD SYMPTOMS was 37.9% (95% CI: 36.0%-39.9%), obesity (OR = 2.09, 95% CI: 1.14-3.95, p = 0.019), smoking (OR = 1.93, 95% CI: 1.25-3.01, p = 0.003), sleep disorders (OR = 2.12, 95% CI: 1.77-2.55, p < 0.001), childhood trauma (OR = 1.42, 95% CI: 1.18-1.71, p < 0.001), and history of mental health conditions (OR = 1.71, 95% CI: 1.34-2.18, p < 0.001). Regular exercise was associated with lower odds of ADHD (OR = 0.55, 95% CI: 0.44-0.70, p < 0.001). Prevalence of ADHD-like symptoms among Egyptian university students is notably high, with multiple lifestyle and psychosocial factors showing significant associations with its occurrence. These findings highlight the need for increased awareness, early screening, and targeted interventions to support affected students. Future research should further investigate the cultural and educational influences on ADHD in Egypt. CI - (c) 2026. The Author(s). FAU - El-Farargy, Sara Hosny AU - El-Farargy SH AUID- ORCID: 0000-0002-3691-7772 AD - Faculty of Medicine, Benha University, Banha, Egypt. FAU - Fawzy, Ahmed Mahmoud AU - Fawzy AM AD - Faculty of Medicine, Port Said University, Port Said, Egypt. Dr.ahmed.mahmoud.hamed@gmail.com. FAU - Elgammal, Ahmed Samy AU - Elgammal AS AUID- ORCID: 0009-0000-0087-7222 AD - Faculty of Medicine, Tanta University, Tanta, Egypt. FAU - Mostafa, Hamed Abdelma'aboud AU - Mostafa HA AD - Faculty of Medicine, Al-Azhar University, Cairo, Egypt. FAU - Husain, Muhammad Ashraf AU - Husain MA AD - Faculty of Medicine, Al-Azhar University, Cairo, Egypt. FAU - Ali, Hossam Tharwat AU - Ali HT AD - Qena Faculty of Medicine, South Valley University, Qena, Egypt. FAU - Abdelmonim, Gasm Alseed AU - Abdelmonim GA AUID- ORCID: 0009-0003-8649-2447 AD - Shendi University Faculty of Medicine, Shendi, Sudan. CN - Egyptian Collaborators Group LA - eng PT - Journal Article DEP - 20260825 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/epidemiology MH - Egypt/epidemiology MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - Universities MH - Male MH - Prevalence MH - Young Adult MH - Female MH - Adult MH - Risk Factors MH - Adolescent MH - Surveys and Questionnaires PMC - PMC13507199 OTO - NOTNLM OT - ADHD OT - ASRS OT - Associated factors OT - Egypt OT - Mental health OT - Prevalence OT - University students COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was conducted in accordance with the ethical standards of the Benha Ethics Committee and the Declaration of Helsinki. Participants were informed about the study's purpose, and informed consent was obtained electronically before participation. Participation was voluntary, with confidentiality assured. Consent for publication: All authors provide consent for the publication of this manuscript. Participants' data were anonymized and aggregated, ensuring privacy and confidentiality. FIR - Atef, Dalia IR - Atef D FIR - Abdel, Islam Ali IR - Abdel IA FIR - Awad, Enas Mitwally IR - Awad EM FIR - Emam, Sally Ashraf IR - Emam SA FIR - Fawzy, Ibrahim Ahmed Ibrahim IR - Fawzy IAI FIR - Mohammed, Alaa Maged IR - Mohammed AM FIR - Abdelmonsef, Elsaeed Saleh IR - Abdelmonsef ES FIR - Alkarram, Mohamed Mahmoud IR - Alkarram MM FIR - Khadrah, Israa Mohamed IR - Khadrah IM FIR - Ellakwa, Doha El-Sayed IR - Ellakwa DE FIR - Abdelkader, Marwa IR - Abdelkader M FIR - Gadalla, Ranim Mohamed Farouk Mohamed Hussein IR - Gadalla RMFMH FIR - Ahmed, Nada Sayed Abdelhamed IR - Ahmed NSA FIR - Alnabwy, Doaa Mohammed IR - Alnabwy DM EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:37 PMCR- 2026/08/25 CRDT- 2026/08/25 23:53 PHST- 2026/01/04 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/26 05:37 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/25 23:53 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.1038/s41598-026-63835-y [pii] AID - 63835 [pii] AID - 10.1038/s41598-026-63835-y [doi] PST - epublish SO - Sci Rep. 2026 Aug 25;16(1):26653. doi: 10.1038/s41598-026-63835-y. PMID- 42642452 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Aug 25 TI - E-healthy diet literacy is associated with psychological well-being and diet-related risk behaviors among university students in Turkiye: a cross-sectional study. LID - 10.1038/s41598-026-68297-w [doi] LID - 26673 AB - E-healthy diet literacy is the ability to find, understand, appraise, and apply online healthy-eating information. We examined its associations with psychological well-being and diet-related risk behaviors in a cross-sectional convenience sample of 331 undergraduates aged 18-26 years in Ankara, Turkiye; 84.9% were female. Participants completed the e-Healthy Diet Literacy Questionnaire (e-HDLQ), World Health Organization-Five Well-Being Index (WHO-5), and Eating Habits Index (EHI). Associations were modeled using multivariable linear regression and an exploratory covariate-adjusted path analysis with 5,000 bootstrap resamples. After multivariable adjustment, higher e-HDLQ scores were associated with higher WHO-5 scores (unstandardized B = 0.443; standardized beta = 0.179; 95% confidence interval [CI] for B, 0.174 to 0.713; p = 0.001) and, in a model additionally including WHO-5, with lower EHI scores (B = - 0.123; beta = -0.281; 95% CI for B, - 0.171 to - 0.075; p < 0.001). A one-standard-deviation higher e-HDLQ score was associated with a WHO-5 score 3.38 percentage points higher and an EHI score 0.94 points lower. The bias-corrected 95% CI for the indirect component through WHO-5 included zero. Associations were modest; the EHI estimate warrants cautious interpretation because internal consistency was low (Cronbach's alpha = 0.56). Concurrent measurement does not establish temporal ordering or causality. CI - (c) 2026. The Author(s). FAU - Tuncer, Esra AU - Tuncer E AUID- ORCID: 0000-0001-7151-842X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Bolu Abant Izzet Baysal University, Bolu, Turkey. FAU - Duman, Emre AU - Duman E AUID- ORCID: 0000-0002-8956-2696 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Siirt University, Siirt, Turkey. emre.duman@siirt.edu.tr. FAU - Sahin Bodur, Gulsum AU - Sahin Bodur G AUID- ORCID: 0000-0001-7450-0428 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Cankiri Karatekin University, Cankiri, Turkey. FAU - Keser, Alev AU - Keser A AUID- ORCID: 0000-0003-2620-6747 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Ankara University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260825 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Students/psychology MH - Universities MH - Young Adult MH - Adolescent MH - Psychological Well-Being MH - Male MH - Adult MH - *Diet, Healthy/psychology MH - *Health Literacy MH - Surveys and Questionnaires MH - Feeding Behavior/psychology MH - Turkey MH - *Risk-Taking PMC - PMC13507282 OTO - NOTNLM OT - Diet-related risk behaviors OT - Path analysis OT - Psychological well-being OT - University students OT - e-healthy diet literacy COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: All procedures were conducted in accordance with the Declaration of Helsinki and were approved by the Ankara University Ethics Committee (Date: 25/04/2024; No: 07/62). Written informed consent was obtained from all participants before data collection. Declaration of generative AI and AI-assisted technologies in the manuscript preparation process: During manuscript preparation, DeepL and ChatGPT were used for English-language editing and translation from Turkish. All outputs were reviewed and revised by the authors, who take responsibility for the final text. EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:37 PMCR- 2026/08/25 CRDT- 2026/08/25 23:46 PHST- 2026/07/11 00:00 [received] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/08/26 05:37 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/25 23:46 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.1038/s41598-026-68297-w [pii] AID - 68297 [pii] AID - 10.1038/s41598-026-68297-w [doi] PST - epublish SO - Sci Rep. 2026 Aug 25;16(1):26673. doi: 10.1038/s41598-026-68297-w. PMID- 32644459 STAT- Publisher CTDT- 20260826 PB - StatPearls Publishing DP - 2026 Jan TI - The Role of Dietary Fiber in Health Promotion and Disease Prevention: A Practical Guide for Clinicians. BTI - StatPearls AB - Despite decades of research showing that dietary fiber is linked to lower rates of cardiovascular disease, type 2 diabetes, and colorectal cancer, most adults consume less than half of the recommended daily amount. For many patients, the advice to "eat more fiber" is familiar but not well understood in practice. Because fiber significantly influences gut health, glycemic control, lipid metabolism, and satiety, it has important implications for preventing and managing chronic diseases. Historical Definitions of Dietary Fiber Dietary fiber is a complex carbohydrate from the structural parts of plant foods, generally classified as soluble or insoluble. Soluble fiber dissolves in water and is partially fermented in the colon, while insoluble fiber does not dissolve and mainly adds bulk to the stool.[ASPEN Adult Nutrition Support Core Curriculum, Fourth Edition. 2025] No single universally accepted definition of dietary fiber has been established. In 1953, E.H. Hipsley of Australia first described fiber as the "nondigestible constituent that makes up the plant cell wall." Since then, many organizations and countries have proposed different definitions. Creating a universally accepted definition remains difficult as researchers discover new compounds that share either the chemical structure or the physiological functions of fiber, but not always both. From a health perspective, fiber is best defined by its physiological effects, eg, supporting regular bowel movements, improving glycemic control, and lowering cholesterol. However, for food labeling and analytical purposes, scientists and regulatory agencies rely on the Association of Official Analytical Chemists' definition, based on chemical and analytical properties. Most definitions agree that fiber is composed of carbohydrates and lignin that resist digestion in the small intestine and are partially or fully fermented in the large intestine, producing beneficial metabolites such as short-chain fatty acids. Understanding these definitions is essential for clinicians, as it supports effective patient counseling, accurate interpretation of nutrition labels, and selection of foods that reliably provide the intended health benefits. Nutritional Impact of Dietary Fiber All dietary fiber comes from plant-based foods, including fruits, vegetables, whole grains, legumes, nuts, and seeds. Fiber plays a vital role in digestion, nutrient absorption, and gastrointestinal health. Soluble fibers, eg, pectin, gums, mucilage, fructans, and some resistant starches, absorb water to form a gel that slows gastric emptying, delays glucose absorption, and blunts postmeal blood sugar spikes. Soluble fiber also binds bile acids, modestly lowering LDL cholesterol levels, and acts as a prebiotic substrate for gut microbiota that produce short-chain fatty acids, which decrease inflammation and support metabolic and immune functions. In contrast, insoluble fiber does not dissolve in water. Insoluble fibers include lignin, cellulose, and hemicellulose, which reduce intestinal transit time and increase fecal bulk to promote digestive regularity. Both soluble and insoluble fibers enhance satiety, aid in weight management, and support cardiovascular and metabolic health. Added, or functional, fiber refers to indigestible carbohydrates that are extracted or isolated from plant sources and have been shown to offer health benefits, including better blood glucose regulation, lower cholesterol, and improved bowel regularity. This category includes certain concentrated or synthetically produced nondigestible carbohydrates, eg, psyllium, resistant starch, inulin, polydextrose, and cellulose. The effects of added fibers vary based on their chemical structure and physical properties, and laboratory-synthesized fibers must demonstrate proven health benefits before being labeled as dietary fiber. Adding fibers to foods can help individuals meet daily fiber goals when the naturally occurring fiber from whole foods is insufficient. Consumers can identify added fibers by looking for terms like "soluble fiber," "psyllium," "inulin," "resistant starch," or "functional fiber," which are listed under total dietary fiber on the Nutrition Facts label. Dietary Fiber Recommendations The recommended adequate daily intake for fiber is 25 g for women and 38 g for men, or 14 g per 1,000 kcal consumed. This recommendation is based on evidence showing protection against coronary heart disease and other chronic diseases. It is supported by the Institute of Medicine, the Academy of Nutrition and Dietetics, and major U.S. guidelines. For children and adolescents, the target intake varies by age and sex, from 19 g daily for young children to 31 to 38 g/day for older boys and 25 to 26 g/day for older girls. Between 2017 and 2020, the mean consumption of dietary fiber by American adults was only 17 g per day, about half of the recommended adequate intake level. Approximately 94% of American children and adults fail to meet the adequate intake levels for dietary fiber. Dietary sources include: Soluble fiber: Fruits high in soluble fiber: apples, pears, citrus, berries, plums, peaches, and apricots. Vegetables high in soluble fiber: carrots, broccoli, Brussels sprouts, sweet potatoes, turnips, onions, and asparagus. Legumes, grains, and seeds high in soluble fiber: beans, lentils, chickpeas, oats, barley, rye, and chia seeds. Insoluble fiber: Fruits high in insoluble fiber: apples and pears with skin, berries (especially raspberries and blackberries), grapes, bananas, and oranges. Vegetables high in insoluble fiber: green beans, cauliflower, zucchini, broccoli stems, leafy greens (spinach, kale, and collards), potatoes, celery, and bell peppers. Other sources of insoluble fiber: whole grains (whole wheat, brown rice, rye, corn bran, and bulgur), nuts and seeds (almonds, walnuts, flaxseeds, chia seeds), legumes (beans, lentils, chickpeas, and peas). CI - Copyright (c) 2026, StatPearls Publishing LLC. FAU - Daley, Sharon F AU - Daley SF AD - Cape Cod Hospital, Hyannis, MA FAU - Vadakekut, Elsa S AU - Vadakekut ES AD - American College of Osteopathic Obstetricians and Gynecologists LA - eng PT - Study Guide PT - Book Chapter PL - Treasure Island (FL) COIS- Disclosure: Sharon F Daley declares no relevant financial relationships with ineligible companies. Disclosure: Elsa S Vadakekut declares no relevant financial relationships with ineligible companies. EDAT- 2026/08/26 00:00 CRDT- 2026/08/26 00:00 AID - NBK559033 [bookaccession] PMID- 42641818 OWN - NLM STAT- MEDLINE DCOM- 20260906 LR - 20260906 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 463 DP - 2026 Nov 15 TI - Tracking arterial stiffness from childhood to adolescence: the role of adiposity and cardiometabolic factors. PG - 134754 LID - S0167-5273(26)00604-2 [pii] LID - 10.1016/j.ijcard.2026.134754 [doi] AB - BACKGROUND: Carotid-femoral pulse wave velocity (PWV) is the gold standard measure of central arterial stiffness and a predictor of cardiovascular events in adults, with growing relevance in pediatric populations. Although PWV increases naturally with age, cardiometabolic risk factors may accelerate this process. This study compared carotid-femoral PWV between non-overweight and overweight/obese adolescents, evaluated its progression from prepubertal age to early adolescence, and identified independent determinants of arterial stiffness. METHODS: This longitudinal study included 118 participants from the Generation XXI cohort (Porto, Portugal) assessed at ages 8-9 and 13-14 years. Carotid-femoral PWV was measured at both time points using a validated portable device. Anthropometric data, office blood pressure, and fasting blood samples for lipid profile, glucose, and insulin were collected. Body mass index (BMI) classification followed World Health Organization references. RESULTS: PWV increased significantly from childhood to adolescence (5.01 +/- 0.47 to 6.30 +/- 1.05 m/s; p < 0.001). At 13-14 years, overweight/obese adolescents had significantly higher PWV than non-overweight peers. PWV at 13-14 years correlated positively with BMI, BMI z-score, systolic and diastolic blood pressure, and fasting glucose. In adjusted models, PWV at 8-9 years (beta = 0.39; p = 0.039) and BMI z-score at 13-14 years (beta = 0.33; p < 0.001) remained independent predictors of PWV at 13-14 years. CONCLUSIONS: Arterial stiffness in early adolescence reflects both vascular tracking from childhood and concurrent adiposity. These findings support early vascular screening and weight management interventions during key developmental periods to optimize long-term cardiovascular health. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Ventura, Daniela AU - Ventura D AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal. FAU - Mosca, Sara AU - Mosca S AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal; EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. FAU - Teixeira, Ana AU - Teixeira A AD - EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. FAU - Mota, Claudia AU - Mota C AD - Pediatric Cardiology Department, ULS Sao Joao, Portugal. FAU - Costa, Ana Luisa AU - Costa AL AD - Pediatric Cardiology Department, ULS Sao Joao, Portugal. FAU - Caldas Afonso, Alberto AU - Caldas Afonso A AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal; EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. FAU - Correia-Costa, Liane AU - Correia-Costa L AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal; EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. Electronic address: lianecosta@icbas.up.pt. LA - eng PT - Journal Article DEP - 20260825 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM MH - Humans MH - *Vascular Stiffness/physiology MH - Child MH - Adolescent MH - Female MH - Male MH - Longitudinal Studies MH - *Adiposity/physiology MH - *Cardiometabolic Risk Factors MH - Pulse Wave Analysis/methods MH - Cohort Studies MH - *Cardiovascular Diseases/physiopathology/epidemiology MH - Carotid-Femoral Pulse Wave Velocity/methods MH - Portugal/epidemiology MH - Body Mass Index OTO - NOTNLM OT - Adolescence OT - Arterial stiffness OT - Cardiovascular risk OT - Childhood obesity OT - Pulse wave velocity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/25 23:33 MHDA- 2026/09/06 23:34 CRDT- 2026/08/25 19:12 PHST- 2026/06/20 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/06 23:34 [medline] PHST- 2026/08/25 23:33 [pubmed] PHST- 2026/08/25 19:12 [entrez] AID - S0167-5273(26)00604-2 [pii] AID - 10.1016/j.ijcard.2026.134754 [doi] PST - ppublish SO - Int J Cardiol. 2026 Nov 15;463:134754. doi: 10.1016/j.ijcard.2026.134754. Epub 2026 Aug 25. PMID- 42641368 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260918 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 162 DP - 2026 Nov TI - Exploring the dose-response relationship between prenatal exercise and postpartum depression: A systematic review and meta-analysis of randomized controlled trials. PG - 104960 LID - S0266-6138(26)00264-0 [pii] LID - 10.1016/j.midw.2026.104960 [doi] AB - IMPORTANCE: Postpartum depression (PPD) is a hidden and widespread global public health crisis affecting millions of mothers and infants annually. Prenatal exercise is a potentially accessible nonpharmacological strategy for PPD prevention, but its optimal dose remains uncertain. OBJECTIVE: To explore the dose-response relationship between prenatal exercise and the incidence of PPD through meta-analysis of randomized controlled trials (RCTs). DATA SOURCES: Systematic searches were conducted in PubMed, Embase, Web of Science, and Cochrane Library using MeSH terms and keywords related to "pregnant women," "prenatal exercise," and "postpartum depression," up to June 23, 2025. STUDY SELECTION: RCTs included examined prenatal exercise interventions in pregnant women without a history of depression, with PPD incidence reported using validated depression scales (such as EPDS, CES-D). Non-RCT studies, duplicate publications, and studies with insufficient data were excluded. DATA EXTRACTION AND SYNTHESIS: Two researchers independently extracted data according to the PRISMA guidelines. A random-effects model was used to pool odds ratios (OR) and their 95% confidence intervals (CI). Linear and nonlinear dose-response models were employed to analyze and evaluate the relationship between exercise dose (measured in METs-min/week) and the incidence of PPD. MAIN OUTCOME(S) AND MEASURE(S): The primary outcome is the incidence of PPD, analyzing its relationship with prenatal exercise dose. RESULTS: Eight RCTs involving 2231 pregnant women were included. The pooled analysis showed that prenatal exercise was associated with a potential reduction in PPD incidence, although the overall effect did not reach statistical significance (OR=0.58, 95% CI [0.33, 1.02]). In dose-stratified analysis, exercise doses >/=500 METs-min/week were associated with significantly lower PPD incidence (OR=0.44, 95% CI [0.24, 0.78]). Subgroup analyses suggested trends toward greater benefits among women aged >/=30 years and those initiating exercise between 14 and 28 weeks of gestation; however, subgroup differences did not reach statistical significance. The linear dose-response trend did not reach statistical significance (p = 0.0533), and neither the overall spline association (p = 0.1704) nor the test for nonlinearity (p = 0.6361) was statistically significant. CONCLUSIONS AND RELEVANCE: Prenatal exercise may be associated with a lower risk of PPD, but the overall pooled effect did not reach statistical significance. Findings concerning >/=500 METs-min/week and the apparent flattening of the dose-response curve should be considered exploratory and require confirmation in larger trials. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Lei, Zhuoling AU - Lei Z AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China. FAU - Ma, Pengwei AU - Ma P AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China. FAU - Xue, Zhuolin AU - Xue Z AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China. FAU - Teo, Eng Wah AU - Teo EW AD - Faculty of Sports and Exercise Science, University of Malaya, Kuala Lumpur 59100, Malaysia. FAU - Li, Junfeng AU - Li J AD - Ministry of Sports, Shandong Technology and Business University, Yantai, 264005, China. Electronic address: 201513386@sdtbu.edu.cn. FAU - Chang, Jindong AU - Chang J AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China; Faculty of Sports and Exercise Science, University of Malaya, Kuala Lumpur 59100, Malaysia. Electronic address: changlai@163.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260820 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Randomized Controlled Trials as Topic MH - *Depression, Postpartum/prevention & control/psychology MH - *Exercise/psychology MH - *Prenatal Care/methods/standards OTO - NOTNLM OT - Depression OT - METs OT - Meta-analysis OT - Postpartum depression OT - Prenatal exercise COIS- Declaration of competing interest All authors declare no conflict of interest. EDAT- 2026/08/25 23:33 MHDA- 2026/08/31 23:43 CRDT- 2026/08/25 18:06 PHST- 2025/09/04 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/31 23:43 [medline] PHST- 2026/08/25 23:33 [pubmed] PHST- 2026/08/25 18:06 [entrez] AID - S0266-6138(26)00264-0 [pii] AID - 10.1016/j.midw.2026.104960 [doi] PST - ppublish SO - Midwifery. 2026 Nov;162:104960. doi: 10.1016/j.midw.2026.104960. Epub 2026 Aug 20. PMID- 42641101 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1998-3905 (Electronic) IS - 0970-4388 (Linking) VI - 44 IP - 4 DP - 2026 Jul 1 TI - Efficacy of high-speed extraoral bitewing versus intraoral bitewing and panoramic for proximal caries in primary molars: A histological validation study. PG - 471-481 LID - 10.4103/jisppd.jisppd_162_26 [doi] AB - INTRODUCTION: Detecting proximal caries in primary teeth is challenging. While intraoral bitewing radiography (IOBW) is the standard for proximal caries assessment, it faces limitations in pediatric patients. Extraoral bitewing radiography (EOBW) addresses these limitations by capturing bilateral posterior dentition within a single exposure. AIMS: The aim of the study was to evaluate the diagnostic efficacy of EOBW (high-speed [HS] and standard [SD] modes) in detecting proximal caries in primary molars compared to IOBW and panoramic radiography (PR), using histological examination as the reference standard. MATERIALS AND METHODS: Fifty-six extracted primary molars, with and without proximal dental caries, were randomly arranged in the 3D-printed skull and mandible. Four radiographic modalities were evaluated: IOBW using size #0 photostimulable phosphor plates, and EOBW-HS, EOBW-SD, and PR using a digital panoramic X-ray unit. Two observers independently graded caries twice at one-week intervals. Scores were compared with the histological reference standard. RESULTS: All modalities showed excellent intraobserver agreement (K > 0.8). For inter-observer agreement, all bitewing techniques demonstrated excellent agreement, whereas PR yielded the lowest. The Wilcoxon signed-rank test showed significant differences in caries grading scores between PR and all the other techniques. Area under the receiver operating characteristic curve indicated good diagnostic value for cavitated dentin caries across all modalities. EOBW demonstrated the highest sensitivity for detecting proximal caries in dentin. CONCLUSIONS: EOBW and IOBW provide comparable radiographic grading across all caries depths. EOBW-HS is an accurate alternative for detecting proximal dentin caries, particularly for pediatric patient's intolerant to intraoral radiography. However, caution should be exercised when enamel caries is suspected. CI - Copyright (c) 2026 Journal of Indian Society of Pedodontics and Preventive Dentistry. FAU - Tunthasen, Piyanuch AU - Tunthasen P AD - Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Tohnak, Sirilawan AU - Tohnak S AD - Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Naivikul, Supanya AU - Naivikul S AD - Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Chantaramanee, Ariya AU - Chantaramanee A AD - Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Sakulratchata, Ruedee AU - Sakulratchata R AD - Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Tunthasen, Rudjit AU - Tunthasen R AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Deepho, Chutamas AU - Deepho C AD - Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. LA - eng PT - Comparative Study PT - Journal Article PT - Validation Study DEP - 20260825 PL - India TA - J Indian Soc Pedod Prev Dent JT - Journal of the Indian Society of Pedodontics and Preventive Dentistry JID - 8710631 SB - IM MH - Humans MH - *Dental Caries/diagnostic imaging/pathology MH - *Molar/diagnostic imaging/pathology MH - *Tooth, Deciduous/diagnostic imaging/pathology MH - *Radiography, Bitewing/methods MH - *Radiography, Panoramic/methods OTO - NOTNLM OT - Bitewing radiography OT - dental digital radiography OT - pediatric dentistry OT - proximal caries detection EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 CRDT- 2026/08/25 15:36 PHST- 2026/04/04 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 15:36 [entrez] AID - 00005097-202607000-00016 [pii] AID - 10.4103/jisppd.jisppd_162_26 [doi] PST - ppublish SO - J Indian Soc Pedod Prev Dent. 2026 Jul 1;44(4):471-481. doi: 10.4103/jisppd.jisppd_162_26. Epub 2026 Aug 25. PMID- 42640944 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260904 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Can different exercise modalities improve esports performance? Study protocol for a 12-week three-arm randomized controlled trial. PG - e0357119 LID - 10.1371/journal.pone.0357119 [doi] LID - e0357119 AB - BACKGROUND: Growing evidence indicates a positive association between physical exercise and both cognitive functions and gaming performance in esports players. However, most existing studies focus on acute or short-term effects and are limited by small sample sizes and a lack of follow-up assessments. Furthermore, comparisons between different exercise modalities remain largely unexplored. Therefore, longitudinal studies comparing optimal exercise protocols and their sustained effects on esports performance are critically needed. OBJECTIVE: This study aims to: (1) investigate and compare the long-term effects of 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on various dimensions of esports performance in first-person shooter (FPS) gamers; (2) examine the sustainability of these effects through a 4-week follow-up assessment; and (3) explore the potential associations between physical competence, psychological skills, and gaming performance. METHODS: In this three-arm randomized controlled trial, 195 FPS gamers (aged 18-29) will be randomly assigned to HIIT, MICT, or control groups. Interventions consist of three weekly sessions for 12 weeks (HIIT: 10 x 1-minute high-intensity bouts interspersed with 1-minute active recovery; MICT: 20-minute continuous moderate-intensity exercise). The primary outcome is flicking capacity (a core metric of esports performance). Secondary outcomes include other gaming operational metrics, esports-related psychological skills, body composition, and physical competence. All outcomes will be assessed at baseline, post-intervention (12 weeks), and follow-up (16 weeks). DISCUSSION: This protocol outlines a standardized longitudinal framework to address the critical lack of evidence-based esports training guidelines. Anticipated findings will further validate the benefits of physical exercise on esports performance, providing essential long-term empirical evidence for integrating optimal exercise modalities into esports training regimens. Furthermore, exploring the associations between physical competence, psychological skills, and operational performance will offer insights into the behavioral pathways of performance enhancement. TRIAL REGISTRATION: ClinicalTrials.gov (NCT07150312). Registered on Aug 29, 2025. CI - Copyright: (c) 2026 Tang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Tang, Di AU - Tang D AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. AD - The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. FAU - Ye, Zheng AU - Ye Z AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. FAU - Ma, Ruisi AU - Ma R AD - School of Physical Education, Jinan University, Guangzhou, China. FAU - Liu, Jinde AU - Liu J AD - Faculty of Physical Education, Fudan University, Shanghai, China. FAU - Ho, Wai Keung AU - Ho WK AUID- ORCID: 0000-0003-0387-9869 AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. FAU - Sum, Raymond Kim Wai AU - Sum RKW AUID- ORCID: 0000-0002-4051-9945 AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. LA - eng SI - ClinicalTrials.gov/NCT07150312 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260825 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *High-Intensity Interval Training/methods MH - Young Adult MH - Adolescent MH - Male MH - Female MH - *Exercise/physiology MH - Research Design PMC - PMC13505923 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 PMCR- 2026/08/25 CRDT- 2026/08/25 13:35 PHST- 2026/03/16 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 13:35 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - PONE-D-26-12376 [pii] AID - 10.1371/journal.pone.0357119 [doi] PST - epublish SO - PLoS One. 2026 Aug 25;21(8):e0357119. doi: 10.1371/journal.pone.0357119. eCollection 2026. PMID- 42640915 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260827 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Circulating CTRP-1 levels are elevated in women with polycystic ovary syndrome: A case-control study. PG - e0356461 LID - 10.1371/journal.pone.0356461 [doi] LID - e0356461 AB - OBJECTIVE: To investigate circulating C1q/TNF-related protein-1 (CTRP-1) levels in women with polycystic ovary syndrome (PCOS) and evaluate its potential association with metabolic and reproductive features of the syndrome. METHODS: A prospective cross-sectional case-control study was conducted between October 2021 and March 2022 including 96 women (48 with PCOS and 48 controls) aged 15-40 years. PCOS was diagnosed according to the 2003 Rotterdam criteria. Anthropometric measurements and fasting venous blood samples were obtained during the early follicular phase. Serum CTRP-1 levels were measured using enzyme-linked immunosorbent assay (ELISA). Metabolic and hormonal parameters, including HOMA-IR, AMH, and androgen levels, were analyzed. Receiver operating characteristic (ROC) analysis and analysis of covariance (ANCOVA) adjusted for age and body mass index (BMI) were performed. RESULTS: Serum CTRP-1 levels were significantly higher in women with PCOS compared with controls (54.9 +/- 5.2 vs. 26.6 +/- 4.8 ng/mL, p < 0.001). CTRP-1 concentrations were associated with several metabolic and hormonal parameters, including BMI, fasting insulin, triglyceride levels, HDL cholesterol, and AMH. ROC curve analysis demonstrated excellent discriminatory ability within this cohort, although these findings should be interpreted cautiously given the relatively small sample size and case-control design. In multivariable analysis adjusting for age and BMI, CTRP-1 remained independently associated with PCOS (beta = 28.97, p < 0.001). CONCLUSION: Circulating CTRP-1 levels are elevated in women with PCOS and appear to be associated with both metabolic and reproductive characteristics of the syndrome. CTRP-1 may represent a potential biomarker related to metabolic dysregulation in PCOS; however, larger prospective and multicenter studies are required to validate its clinical and diagnostic utility. CI - Copyright: (c) 2026 Ali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ali, Cavide AU - Ali C AUID- ORCID: 0000-0001-6188-1516 AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. AD - Obstetrics and Gynecology Clinic, Kadikoy Acibadem Hospital, Istanbul, Turkey. FAU - Sayir, Alper AU - Sayir A AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Ocba, Feride AU - Ocba F AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Ozturk Atan, Deniz AU - Ozturk Atan D AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Harmanci, Melike Sevde AU - Harmanci MS AUID- ORCID: 0000-0002-5629-2036 AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Surecek, Mustafa Cem AU - Surecek MC AD - Department of Obstetrics and Gynecology, Canakkale Onsekiz Mart University, Canakkale, Turkiye. FAU - Gulerman, Hacer Cavidan AU - Gulerman HC AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (C1QTNF1 protein, human) RN - 0 (Biomarkers) RN - 0 (Proteins) SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/blood MH - Case-Control Studies MH - Adult MH - Young Adult MH - Adolescent MH - Cross-Sectional Studies MH - Prospective Studies MH - Body Mass Index MH - ROC Curve MH - Biomarkers/blood MH - Proteins PMC - PMC13505912 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 PMCR- 2026/08/25 CRDT- 2026/08/25 13:34 PHST- 2026/04/07 00:00 [received] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 13:34 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - PONE-D-26-16139 [pii] AID - 10.1371/journal.pone.0356461 [doi] PST - epublish SO - PLoS One. 2026 Aug 25;21(8):e0356461. doi: 10.1371/journal.pone.0356461. eCollection 2026. PMID- 42640905 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260827 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Identification and risk-factor analysis for individuals at high risk for keratoconus via machine learning and logistic regression. PG - e0354924 LID - 10.1371/journal.pone.0354924 [doi] LID - e0354924 AB - PURPOSE: To evaluate keratoconus (KC) risk factors and to develop a machine-learning (ML) model for KC and myopia classification. METHODS: In this retrospective single-center cross-sectional study, demographic and lifestyle data from patients with KC and individuals from a preoperative refractive surgery clinic were collected from January 20, 2024, to December 1, 2024. Univariable and multivariable regression analyses were used to identify key risk factors. Additionally, random forest (RF)-recursive feature elimination (RFE), extreme gradient boosting (XGBoost)-RFE, and univariable logistic regression were applied to select factors for ML models. Seven ML models were developed for a lifestyle-based classification system, with the performance being validated through discrimination and calibration, and interpretability being improved using SHapley Additive exPlanations (SHAP). RESULTS: Analysis of 711 patients (mean [standard deviation] age, 26.6 [7.1] years; 439 males [61.7%]) revealed 275 with KC. Multivariable regression analysis identified seven risk factors for KC, including male sex, higher body-mass index (BMI), lower education level, more distant childhood residence, allergic conjunctivitis, and increased eye-rubbing intensity and frequency. After feature selection of 24 variables, the neural-network model demonstrated the highest performance (area under the receiver operating characteristic curve [AUROC] = 0.79), followed by RF (AUROC = 0.77) and XGBoost (AUROC = 0.76). SHAP analysis consistently highlighted eye-rubbing intensity, sex, BMI, and childhood residence among the top 10 factors across the top three models, which were also confirmed by univariable logistic regression. CONCLUSION: ML models can distinguish high-risk KC groups based on clinical risk factors, facilitating risk stratification and early lifestyle interventions. CI - Copyright: (c) 2026 Du et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Du, Kaiyue AU - Du K AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Peng, Rongmei AU - Peng R AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Chen, Yueguo AU - Chen Y AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Yuan, Bowei AU - Yuan B AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Chen, Wei AU - Chen W AD - Institute of Automation, Chinese Academy of Sciences, Beijing, China. FAU - Han, Liang AU - Han L AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Xiao, Gege AU - Xiao G AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Qu, Yi AU - Qu Y AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Hong, Jing AU - Hong J AUID- ORCID: 0000-0002-8079-2073 AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Keratoconus/epidemiology/etiology/diagnosis MH - Female MH - Risk Factors MH - Male MH - *Machine Learning MH - Logistic Models MH - Retrospective Studies MH - Adult MH - Cross-Sectional Studies MH - Random Forest MH - Boosting Machine Learning Algorithms MH - Predictive Learning Models MH - Classification Algorithms MH - Young Adult PMC - PMC13505905 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 PMCR- 2026/08/25 CRDT- 2026/08/25 13:34 PHST- 2025/06/03 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 13:34 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - PONE-D-25-28249 [pii] AID - 10.1371/journal.pone.0354924 [doi] PST - epublish SO - PLoS One. 2026 Aug 25;21(8):e0354924. doi: 10.1371/journal.pone.0354924. eCollection 2026. PMID- 42640180 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260903 IS - 1469-0705 (Electronic) IS - 0960-7692 (Print) IS - 0960-7692 (Linking) VI - 68 IP - 3 DP - 2026 Sep TI - Modified umbilical artery Doppler scoring system based on multisite assessment: association with perinatal outcome in early and late fetal growth restriction. PG - 341-350 LID - 10.1002/uog.70319 [doi] AB - OBJECTIVES: To evaluate a novel bilateral, segment-based umbilical artery (UA) Doppler scoring system in pregnancies complicated by early- or late-onset fetal growth restriction (FGR) and to investigate its association with adverse perinatal outcome. METHODS: This single-center prospective cohort study, conducted between May 2025 and December 2025, included singleton pregnancies diagnosed with FGR according to Delphi consensus criteria. Bilateral UA Doppler measurements were obtained from six predefined anatomical sites: the perivesical segment, the free-loop segment and the placental insertion site in each UA. End-diastolic flow at each site was categorized as present, absent or reversed and incorporated into a cumulative UA Doppler score (0-18 points). Composite adverse perinatal outcome (CAPO) was defined as the occurrence of at least one of the following: neonatal hypoglycemia, need for phototherapy, neonatal sepsis, respiratory distress syndrome, need for continuous positive airway pressure, need for mechanical ventilation, 5-min Apgar score < 7 or admission to the neonatal intensive care unit (NICU). Participants were stratified by UA Doppler score (< 3 vs >/= 3 points). Multivariable logistic regression analysis was used to assess the association between UA Doppler score as a continuous or dichotomized variable and CAPO, adjusting for maternal age, body mass index, parity, mode of conception, estimated fetal weight percentile and gestational age at delivery. In addition, the prevalence of individual markers of fetoplacental hemodynamic deterioration, including abnormal ductus venosus Doppler, cerebroplacental ratio < 5(th) percentile, intrauterine fetal demise, fetal distress leading to delivery and 5-min Apgar score < 7, was analyzed across UA Doppler score categories (0-2, 3-5, 6-8, 9-12 and > 12 points). RESULTS: A total of 251 pregnancies with FGR were included, of which 117 were early onset (< 32 weeks' gestation) and 134 were late onset (>/= 32 weeks' gestation). Higher UA Doppler scores (>/= 3 points) were associated significantly with preterm delivery and higher rates of NICU admission and CAPO in both early- and late-onset FGR. In early-onset FGR, higher scores were associated additionally with lower birth weight. The UA Doppler score remained associated independently with CAPO on multivariable logistic regression analysis. A significant linear trend was observed across increasing UA Doppler score categories for the rate of CAPO and individual markers of fetoplacental hemodynamic deterioration. CONCLUSIONS: In pregnancies complicated by early-onset or late-onset FGR, a higher UA Doppler score based on a multisite bilateral scoring system is associated independently with adverse perinatal outcome. These findings support the feasibility of a segment-based approach to UA Doppler assessment. Further studies are required to determine the clinical benefit and feasibility of adoption within current surveillance strategies. (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. FAU - Bulan, D D AU - Bulan DD AUID- ORCID: 0000-0001-9983-2306 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Bayraktar, B AU - Bayraktar B AUID- ORCID: 0000-0001-6233-4207 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. AD - Department of Obstetrics and Gynecology, Division of Perinatology, Turgut Ozal University Malatya Training and Research Hospital, Malatya, Turkey. FAU - Dayanan, R AU - Dayanan R AUID- ORCID: 0000-0002-8192-8841 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Ozkan, M A AU - Ozkan MA AUID- ORCID: 0000-0002-2437-9719 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Tonyali, N V AU - Tonyali NV AUID- ORCID: 0000-0002-7284-6887 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Seyhanli, Z AU - Seyhanli Z AUID- ORCID: 0000-0003-3924-3723 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Yilmaz, Z V AU - Yilmaz ZV AUID- ORCID: 0000-0002-8719-1879 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260825 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - *Fetal Growth Retardation/diagnostic imaging MH - *Umbilical Arteries/diagnostic imaging MH - Pregnancy MH - Female MH - Prospective Studies MH - *Ultrasonography, Doppler/methods MH - *Ultrasonography, Prenatal/methods MH - Adult MH - Infant, Newborn MH - Pregnancy Outcome MH - Gestational Age PMC - PMC13532136 OTO - NOTNLM OT - Doppler scoring system OT - adverse perinatal outcome OT - fetal growth restriction OT - perinatal outcome OT - umbilical artery Doppler EDAT- 2026/08/25 11:38 MHDA- 2026/09/01 11:39 PMCR- 2026/09/01 CRDT- 2026/08/25 09:53 PHST- 2026/03/28 00:00 [revised] PHST- 2025/12/15 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/01 11:39 [medline] PHST- 2026/08/25 11:38 [pubmed] PHST- 2026/08/25 09:53 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - UOG70319 [pii] AID - 10.1002/uog.70319 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2026 Sep;68(3):341-350. doi: 10.1002/uog.70319. Epub 2026 Aug 25. PMID- 42639017 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260825 LR - 20260826 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - Composite fiber remodels gut microbiota and shows a trend of alleviating dyspepsia in adolescents with functional dyspepsia: a 16S rRNA pilot study. PG - 1844725 LID - 10.3389/fmicb.2026.1844725 [doi] LID - 1844725 AB - BACKGROUND: Adolescent functional dyspepsia (FD) is highly prevalent and closely linked to intestinal microbiota imbalance. Dietary fiber exerts prebiotic effects by regulating gut microbiota, but targeted studies investigating whether composite fiber can modulate gut microbiota and alleviate dyspeptic symptoms in adolescent FD patients remain scarce. This pilot trial aimed to explore the gut microbial regulatory characteristics and symptomatic improvement trend of standardized composite fiber supplementation. METHODS: Thirty-two adolescents with FD were enrolled in a 28-day double-blind, placebo-controlled pilot trial (treatment group: n = 15, 15 g/d composite fiber; control group: n = 17, isoenergetic maltodextrin). Fecal samples were collected post-intervention for 16S rRNA V3-V4 region sequencing. Microbial functional potential was predicted via PICRUSt1, and Fisher's exact conditional MLE was adopted to compare the binary symptom improvement rates. RESULTS: Composite fiber elevated all alpha-diversity indices (FDR < 0.05) and separated gut communities (weighted UniFrac PERMANOVA: F = 68.3, R(2) = 0.237, p = 0.018), independent of demographics. The intervention was associated with an increased abundance of Akkermansia, Romboutsia, and [Eubacterium]_coprostanoligenes_group, while being associated with a reduction in [Ruminococcus]_gnavus_group and Veillonella. Notably, cross-sectional FD case-control studies reported contradictory shifts of these genera, and microbial responses to intervention show prominent context-dependent heterogeneity across published research. PICRUSt1-based functional prediction suggested significant upregulation of steroid and flavonoid biosynthesis pathways in the treatment group. The symptom improvement rate was numerically higher in the treatment group (66.7% vs. 47.1%), although this difference was not statistically significant (p = 0.3075, OR = 2.19, 95% CI: 0.44-12.15). CONCLUSION: Composite fiber intervention reshapes gut microbial diversity, community structure and predicted metabolic functional profiles in adolescents with FD, alongside a non-significant numerical trend toward the alleviation of dyspeptic discomfort. Owing to substantial inter-study heterogeneity and context-dependent microbial responses, the observed genus-level alterations cannot be unequivocally characterized as uniformly beneficial outcomes, nor can direct causal relationships between single microbial taxa and clinical symptom improvement be inferred, as formal mediation analyses were not performed. This pilot study provides preliminary microbiological evidence for a fiber-based non-pharmacological intervention. Large multi-center trials combining multi-omics datasets and formal mediation analysis are required to validate clinical efficacy and untangle complex microbiota-symptom associations. CI - Copyright (c) 2026 Yu, Lv, Yang, Zhang, Yang, Wei, Zhang and Li. FAU - Yu, Chengrui AU - Yu C AD - Shihezi University School of Public Health, Shihezi, China. FAU - Lv, Jingsen AU - Lv J AD - Forevergen Biosciences Co, Ltd., Guangzhou, China. FAU - Yang, Jianli AU - Yang J AD - Department of Radiology, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Zhang, Yanping AU - Zhang Y AD - Department of Clinical Laboratory, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Yang, Ting AU - Yang T AD - Department of Pathology, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Wei, Yuan AU - Wei Y AD - Department of Oncology, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Zhang, Yuan AU - Zhang Y AD - Department of Colorectal Surgery, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Li, Jiaying AU - Li J AD - Department of Teaching Research, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. AD - School of Food Science and Technology, Shihezi University, Shihezi, Xinjiang, China. LA - eng PT - Journal Article DEP - 20260810 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC13500627 OTO - NOTNLM OT - 16S rRNA sequencing OT - adolescents OT - composite dietary fiber OT - functional dyspepsia OT - gut microbiota COIS- JLv was employed by the Forevergen Biosciences Co, Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/25 11:38 MHDA- 2026/08/25 11:39 PMCR- 2026/08/10 CRDT- 2026/08/25 05:58 PHST- 2026/04/01 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/25 11:39 [medline] PHST- 2026/08/25 11:38 [pubmed] PHST- 2026/08/25 05:58 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1844725 [doi] PST - epublish SO - Front Microbiol. 2026 Aug 10;17:1844725. doi: 10.3389/fmicb.2026.1844725. eCollection 2026. PMID- 42639006 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260826 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Pediatric hyperuricemia: genetic basis, metabolic mechanisms, and clinical implications. PG - 1841803 LID - 10.3389/fendo.2026.1841803 [doi] LID - 1841803 AB - Hyperuricemia (HUA) is a heterogeneous group of metabolic disorders caused by long-term disturbances in purine metabolism. In recent years, although adult HUA and gout have been extensively studied, the understanding of HUA and gout in children and adolescents remains insufficient. Diagnostic criteria for adult HUA are well-established, but no consensus has yet been reached regarding its definition in children and adolescents. This review summarizes the current understanding of pediatric HUA, emphasizing its genetic basis, metabolic mechanisms, and clinical associations. ATP-binding cassette subfamily G member 2 (ABCG2) dysfunction, gene-defined forms of autosomal dominant tubulointerstitial kidney disease (ADTKD), particularly ADTKD-UMOD and ADTKD-REN, and selected purine metabolism disorders contribute to early-onset HUA, gout, nephrolithiasis, and renal involvement. Obesity-related insulin resistance (IR) may promote urate accumulation through pathways linked to oxidative stress, endothelial dysfunction, and inflammasome activation. Persistent elevation of uric acid (UA) has been associated with chronic kidney disease (CKD) progression, elevated blood pressure (BP), and subclinical cardiovascular remodeling. However, many of these mechanistic associations are supported primarily by adult and experimental studies and require further validation in children. We also review non-pharmacological management and indication-based pharmacological treatment strategies for pediatric HUA. These indications include asymptomatic hyperuricemia (AH), pediatric gout, UA nephrolithiasis, inherited purine metabolism disorders, CKD-associated HUA, and tumor lysis syndrome (TLS)-associated acute HUA, with emphasis on pediatric evidence, regulatory approval, off-label use, dosing, monitoring, and safety. In children, asymptomatic serum urate elevation is often the first recognized presentation, whereas nephrolithiasis, gout, renal dysfunction, or acute HUA should prompt evaluation for genetic, metabolic, renal, or treatment-related causes. These findings underscore the need for early identification and personalized intervention in children with HUA to prevent long-term renal and metabolic complications. CI - Copyright (c) 2026 Zhou, Lv, Hong, Liu, Jin, Zhang and Liu. FAU - Zhou, Jing AU - Zhou J AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Lv, Jianing AU - Lv J AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Hong, Chunhuan AU - Hong C AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Liu, Qinhao AU - Liu Q AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Jin, Shuqing AU - Jin S AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Zhang, Yi AU - Zhang Y AD - Department of Pharmacology, Shanxi Medical University, Taiyuan, China. AD - Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan, China. FAU - Liu, Yunfeng AU - Liu Y AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. LA - eng PT - Journal Article PT - Review DEP - 20260810 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 268B43MJ25 (Uric Acid) SB - IM MH - Humans MH - *Hyperuricemia/genetics/metabolism MH - Child MH - Uric Acid/metabolism MH - Adolescent PMC - PMC13501462 OTO - NOTNLM OT - children and adolescents OT - chronic kidney disease OT - obesity OT - pediatric hyperuricemia OT - urate-lowering therapy OT - uric acid COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/25 11:38 MHDA- 2026/08/25 11:39 PMCR- 2026/08/10 CRDT- 2026/08/25 05:56 PHST- 2026/03/29 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/08/25 11:39 [medline] PHST- 2026/08/25 11:38 [pubmed] PHST- 2026/08/25 05:56 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.3389/fendo.2026.1841803 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 10;17:1841803. doi: 10.3389/fendo.2026.1841803. eCollection 2026. PMID- 42638524 OWN - NLM STAT- Publisher LR - 20261006 IS - 1537-6591 (Electronic) IS - 1058-4838 (Linking) DP - 2026 Aug 25 TI - When Choosing Antiretroviral Therapy Meets Immigration Policy: An Ethical Analysis. LID - ciag442 [pii] LID - 10.1093/cid/ciag442 [doi] AB - Migration policies increasingly shape the conditions of care for migrants living with HIV. In France, access to residence permits on medical grounds intersects with clinical practice, raising important ethical challenges. We describe a 29-year-old woman from Guinea living in France with HIV and severe obesity, with an irregular migration status. Although virologically stable on oral antiretroviral therapy, she requests a switch to a long-acting injectable regimen, motivated by both anticipated administrative implications and the desire for greater discretion. Through this case, we examine how therapeutic reasoning in HIV care may be shaped by legal and social determinants. Using the principlism framework of Beauchamp and Childress, complemented by Tronto's ethics of care, we highlight tensions related to justice, beneficence, non-maleficence, and autonomy. Uncertainty surrounding administrative decision-making may lead patients and clinicians to perceive treatment choices as influencing legal outcomes. Differences between oral and injectable regimens raise issues of equity, feasibility, and social impact. Risks related to treatment interruption, particularly in contexts of legal instability, further complicate clinical reasoning. This case underscores the need to integrate legal and social determinants into therapeutic reasoning and supports the development of guidance from professional societies to assist clinicians facing these complex decisions. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Diarra, Ava AU - Diarra A AUID- ORCID: 0000-0001-5468-0695 AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Vignier, Nicolas AU - Vignier N AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. AD - Universite Sorbonne Paris Nord and Universite Paris Cite, Inserm, UFR SMBH, IAME, UMR 1137, Paris, France. FAU - Tantet, Claire AU - Tantet C AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Petit, Bettina AU - Petit B AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Delagreverie, Heloise AU - Delagreverie H AD - Department of Virology, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Milleliri, Ornella AU - Milleliri O AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Bouchaud, Olivier AU - Bouchaud O AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. AD - Universite Sorbonne Paris Nord and Universite Paris Cite, IRD, Inserm, CEPED, UMR 196, Bobigny, France. FAU - Goupil de Bouille, Jeanne AU - Goupil de Bouille J AUID- ORCID: 0000-0002-3013-9850 AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. AD - Laboratoire Educations et Promotion de la Sante,Universite Sorbonne Paris Nord, LEPS, Bobigny, France. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - Clin Infect Dis JT - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JID - 9203213 SB - IM OTO - NOTNLM OT - HIV OT - anti retroviral therapy OT - migrant COIS- Potential conflicts of interest. A. D. received a grant from IDSA and payment honoraria from Shionogi. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. EDAT- 2026/08/25 05:34 MHDA- 2026/08/25 05:34 CRDT- 2026/08/25 04:03 PHST- 2026/02/05 00:00 [received] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/08/25 05:34 [pubmed] PHST- 2026/08/25 04:03 [entrez] AID - 8769915 [pii] AID - 10.1093/cid/ciag442 [doi] PST - aheadofprint SO - Clin Infect Dis. 2026 Aug 25:ciag442. doi: 10.1093/cid/ciag442. PMID- 42637574 OWN - NLM STAT- Publisher LR - 20260824 IS - 1476-6256 (Electronic) IS - 0002-9262 (Linking) DP - 2026 Aug 25 TI - Methodological approaches to reducing misclassification bias in exclusive breastfeeding measurement. LID - kwag197 [pii] LID - 10.1093/aje/kwag197 [doi] AB - Exclusive breastfeeding is a key pillar of healthy nutrition in infancy. While the importance of breastfeeding is undisputed, measuring early breastfeeding behavior remains challenging. This study evaluated the impact of addressing missingness in feeding variables, incorporating prelacteal feeding, reducing sampling bias through age weighting, and adjusting measurement periods on estimated exclusive breastfeeding prevalence. We show that imputing missing values reduces estimated prevalence from 42.9% (95% CI, 40.3-45.6) to 41.2% (95% CI, 38.5-44.0). Including prelacteal feeding in the definition further decreases estimates to 32.2% (95% CI, 29.5-34.8), while applying age weights slightly increased the prevalence to 33.6% (95% CI, 31.0-36.3). Measuring exclusive breastfeeding compliance at 6 months, rather than looking at average feeding behavior in the first six months of an infant's life, yields an estimated exclusive breastfeeding prevalence of 5.9% (95% CI, 4.6-7.6). Given the major differences in exclusive breastfeeding prevalence estimates from different methodological adjustments, a standardized exclusive breastfeeding measurement is urgently needed to accurately assess early-life nutrition and guide policy based on reliable and comparable estimates. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. FAU - Khoury, Stephanie M AU - Khoury SM AUID- ORCID: 0000-0002-8888-276X AD - University of Basel, Basel, Switzerland. AD - Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland. FAU - Fink, Gunther AU - Fink G AD - University of Basel, Basel, Switzerland. AD - Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland. FAU - Grunig, Marc AU - Grunig M AD - University of Basel, Basel, Switzerland. AD - Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland. FAU - Joseph, Anny-Claude AU - Joseph AC AD - Department of Mathematics and Statistics, Wellesley College, Massachusetts, United States of America. FAU - Wallenborn, Jordyn T AU - Wallenborn JT AD - University of Basel, Basel, Switzerland. AD - Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - Am J Epidemiol JT - American journal of epidemiology JID - 7910653 SB - IM OTO - NOTNLM OT - demographic and health surveys OT - exclusive breastfeeding OT - measurement OT - misclassification bias OT - multiple imputation OT - prevalence EDAT- 2026/08/24 23:34 MHDA- 2026/08/24 23:34 CRDT- 2026/08/24 21:43 PHST- 2026/04/01 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/08/24 23:34 [medline] PHST- 2026/08/24 23:34 [pubmed] PHST- 2026/08/24 21:43 [entrez] AID - 8769871 [pii] AID - 10.1093/aje/kwag197 [doi] PST - aheadofprint SO - Am J Epidemiol. 2026 Aug 25:kwag197. doi: 10.1093/aje/kwag197. PMID- 42636779 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261016 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 527 DP - 2026 Oct 30 TI - Residual allergenicity in commercial partially and extensively hydrolyzed infant formulas: A combined immunological and mass spectrometric study. PG - 150876 LID - S0308-8146(26)03036-0 [pii] LID - 10.1016/j.foodchem.2026.150876 [doi] AB - Hypoallergenic infant formulas are widely used for dietary management of cow's milk allergy in infants, yet reliable assessment of residual allergenicity remains important. This study combined immunological assays with high-resolution peptidomics to evaluate the residual allergenicity of partially hydrolyzed (PHF) and extensively hydrolyzed (EHF) products registered as Foods for Special Medical Purposes in China. A laboratory-scale whey protein hydrolysate (WPH) was also prepared for comparison of hydrolysis efficiency and epitope resistance. The PHFs showed marked heterogeneity, with degree of hydrolysis (DH) values below 28% and several products retaining intact allergenic proteins and IgE-binding reactivity. The EHFs showed higher DH values ranging from 36.6% to 83.7%, but beta-lactoglobulin-derived epitopes, including regions 108-116, 118-140 and 165-178, persisted across commercial EHFs and laboratory WPH. These findings indicate that epitope-level analysis can complement conventional hydrolysis parameters in assessing residual allergenicity of hydrolyzed infant formulas. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Zhang, Qiaozhi AU - Zhang Q AD - School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China. FAU - Huang, Feiyang AU - Huang F AD - School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China. FAU - Ye, Aiqian AU - Ye A AD - Riddet Institute, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand. FAU - He, Jian AU - He J AD - Nutrition and Health Research Center, National Center of Technology Innovation for Dairy, Inner Mongolia 622651, China. FAU - Duan, Sufang AU - Duan S AD - Nutrition and Health Research Center, National Center of Technology Innovation for Dairy, Inner Mongolia 622651, China. FAU - Yan, Yalu AU - Yan Y AD - Nutrition and Health Research Center, National Center of Technology Innovation for Dairy, Inner Mongolia 622651, China. FAU - Sheng, Huadong AU - Sheng H AD - National Pre-packaged Food Quality Supervision and Inspection Center, Zhejiang Fangyuan Test Group Co., LTD., Hangzhou 310018, China. FAU - Gao, Zhongshan AU - Gao Z AD - Allergy Research Center, Zhejiang University, Hangzhou 310058, PR China. FAU - Huang, Hua AU - Huang H AD - Quzhou Institute for Food and Drug Control, Quzhou 324000, China. Electronic address: 43719437@qq.com. FAU - Fu, Linglin AU - Fu L AD - School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China. Electronic address: fulinglin@zjgsu.edu.cn. LA - eng PT - Journal Article DEP - 20260822 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 0 (Allergens) RN - 37341-29-0 (Immunoglobulin E) RN - 0 (Protein Hydrolysates) RN - 0 (Lactoglobulins) RN - 0 (Whey Proteins) SB - IM MH - *Infant Formula/chemistry/economics MH - Humans MH - Hydrolysis MH - *Allergens/immunology/chemistry/analysis MH - *Milk Hypersensitivity/immunology MH - Immunoglobulin E/immunology MH - Mass Spectrometry MH - Infant MH - Animals MH - Protein Hydrolysates/chemistry MH - Lactoglobulins/immunology/chemistry MH - Whey Proteins/chemistry/immunology OTO - NOTNLM OT - Allergenic epitopes OT - Cow's milk allergy OT - Hydrolyzed infant formulas OT - Residual allergenicity OT - Beta-Lactoglobulin COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/24 23:34 MHDA- 2026/10/16 05:32 CRDT- 2026/08/24 18:10 PHST- 2026/01/04 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/10/16 05:32 [medline] PHST- 2026/08/24 23:34 [pubmed] PHST- 2026/08/24 18:10 [entrez] AID - S0308-8146(26)03036-0 [pii] AID - 10.1016/j.foodchem.2026.150876 [doi] PST - ppublish SO - Food Chem. 2026 Oct 30;527:150876. doi: 10.1016/j.foodchem.2026.150876. Epub 2026 Aug 22. PMID- 42636716 OWN - NLM STAT- Publisher LR - 20260824 IS - 1557-8615 (Electronic) IS - 0883-9441 (Linking) VI - 97 DP - 2026 Aug 24 TI - Tandem ECMO/CRRT medical nutrition therapy clinical practice points: A literature review and Delphi consensus on clinical practice. PG - 155711 LID - S0883-9441(26)00289-3 [pii] LID - 10.1016/j.jcrc.2026.155711 [doi] AB - BACKGROUND: Patients who undergo tandem extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) have a high risk of metabolic disturbances, malnutrition, and fluid imbalances. ECMO/CRRT tandem therapy is becoming more prevalent in use; however, there are limited evidence-based guidelines for optimizing nutritional management. In this review, we examine the current literature on nutritional strategies for tandem ECMO and CRRT patients and provisional, consensus-informed clinical practice points to support individualized nutritional interventions. METHODS: We present a literature review with provisional, consensus-informed clinical practice points using a modified Delphi process. A literature search was conducted in PubMed and included studies discussing ECMO, CRRT, or tandem nutritional support in all age groups. Data extraction was standardized, and risk bias was assessed using the Newcastle-Ottawa Scale. Statements were considered clinically relevant practice points if more than 70% of respondents assigned them a rating of 3 or higher on a 5-point Likert scale. Statements identified as needing additional evidence were categorized as recommendations for future research. RESULTS: The review identified key areas critical for nutritional management in ECMO/CRRT patients: (1) early malnutrition assessment within 48 h of ICU admission, (2) individualized energy and protein requirement estimations accounting for device-specific challenges, (3) aggressive fluid and electrolyte monitoring, (4) preference for early enteral nutrition with parenteral nutrition as a safe alternative when needed, (5) early timing of nutrition initiation, (6) heightened protein targets (2-2.5 g/kg/day for adults; 3-3.5 g/kg/day for pediatrics), (7) careful carbohydrate and lipid administration to avoid metabolic complications, and (8) proactive replacement of vitamins and trace elements lost through CRRT. These recommendations are summarized in clinical practice points for bedside implementation. CONCLUSIONS: This review presents a structured set of provisional, expert consensus-informed clinical practice points for the nutritional management of patients undergoing tandem ECMO/CRRT therapy. While numerous studies address nutrition in the context of either ECMO or CRRT, none were found to specifically examine nutritional strategies in patients receiving both therapies simultaneously. This gap significantly limits the direct applicability of existing evidence to patients on ECMO and CRRT. Nevertheless, the review highlights the critical role of optimized nutritional interventions in improving outcomes, including survival and complication rates, in these critically ill patients. The findings underscore the urgent need for targeted research to validate these preliminary recommendations and to establish evidence-based nutritional goals for this complex and vulnerable population. REGISTRATION: PROSPERO ID: CRD420250651962. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Sathik, Nafees AU - Sathik N AD - College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA. Electronic address: nsathik@neomed.edu. FAU - Ghose, Shaarav AU - Ghose S AD - College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA. FAU - Lussier, Natalie AU - Lussier N AD - Akron Children's Hospital, Akron, OH, USA. FAU - Vitale, Victoria AU - Vitale V AD - Akron Children's Hospital, Akron, OH, USA. FAU - Keller, Gerri AU - Keller G AD - Akron Children's Hospital, Akron, OH, USA. FAU - Lussier, Jack AU - Lussier J AD - Akron Children's Hospital, Akron, OH, USA. FAU - Ghazoul, Adam AU - Ghazoul A AD - College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA. FAU - Bunchman, Timothy AU - Bunchman T AD - Pediatric Nephrology, Transplantation, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, USA. FAU - Kakajiwala, Aadil AU - Kakajiwala A AD - Department of Pediatrics, Division of Nephrology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. FAU - Raimer, Patricia AU - Raimer P AD - Akron Children's Hospital, Division of Critical Care, Akron, OH, USA. FAU - Raina, Rupesh AU - Raina R AD - College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA; Department of Nephrology, Akron Nephrology Associates at Cleveland Clinic Akron General Medical Center, Akron, OH, USA. LA - eng PT - Journal Article PT - Review DEP - 20260824 PL - United States TA - J Crit Care JT - Journal of critical care JID - 8610642 SB - IM OTO - NOTNLM OT - CRRT OT - Critical care nutrition OT - ECMO OT - Nutritional management OT - Tandem therapy COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/24 23:34 MHDA- 2026/08/24 23:34 CRDT- 2026/08/24 18:08 PHST- 2025/11/24 00:00 [received] PHST- 2026/07/04 00:00 [revised] PHST- 2026/08/08 00:00 [accepted] PHST- 2026/08/24 23:34 [medline] PHST- 2026/08/24 23:34 [pubmed] PHST- 2026/08/24 18:08 [entrez] AID - S0883-9441(26)00289-3 [pii] AID - 10.1016/j.jcrc.2026.155711 [doi] PST - aheadofprint SO - J Crit Care. 2026 Aug 24;97:155711. doi: 10.1016/j.jcrc.2026.155711. PMID- 42635812 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Aug 24 TI - Effects of active breaks on attention and executive function in children and adolescents: A meta-analysis. LID - 690 [pii] LID - 10.1007/s00431-026-07341-3 [doi] AB - Executive function and attention are essential cognitive abilities that support learning, behavioral regulation, and long-term developmental outcomes in children and adolescents. In modern school environments, prolonged sedentary classroom time may negatively affect cognitive performance. Active breaks, defined as short bouts of physical activity embedded within classroom instruction, have been proposed as a practical strategy to increase physical activity and improve cognitive functioning. However, previous studies and reviews have reported inconsistent findings regarding their effectiveness, particularly across different subcomponents of executive function. This meta-analysis aimed to quantify the effects of classroom-based active breaks on attention, inhibitory control, working memory, and cognitive flexibility in children and adolescents. Four databases, namely PubMed, Cochrane Library, Embase, and Web of Science, were searched for randomized controlled trials assessing the effects of active breaks on attention and executive function in children and adolescents. The search covered the period from the inception of the databases until March 2026. Two researchers independently conducted literature screening, data extraction, and quality assessment. Meta-analysis was performed using Stata 15.1. Twenty-five randomized controlled trials were included. Pooled estimates favored active breaks for attention (SMD = - 0.53) and inhibitory control (SMD = - 0.49), and also favored active breaks for working memory and cognitive flexibility. Exploratory subgroup analyses suggested that 5-15-min, acute, and single-session formats may be associated with larger pooled cognitive effects, although these patterns should be interpreted cautiously. CONCLUSION: The available RCT evidence suggests that classroom-based active breaks may be associated with improvements in attention and executive function in children and adolescents. Short activity breaks integrated into lessons may represent a practical strategy for supporting cognitive functioning; however, substantial heterogeneity and uncertainty in the subgroup findings warrant cautious interpretation. WHAT IS KNOWN: * Prolonged sedentary classroom time may negatively affect attention and executive function in children and adolescents. * Active breaks are feasible school-based physical activity strategies, but previous evidence on cognitive benefits remains inconsistent. WHAT IS NEW: * This meta-analysis of 25 randomized controlled trials found pooled effects favoring active breaks across attention and executive function domains, although confidence in the exact magnitude of benefit is limited by considerable heterogeneity. * Exploratory subgroup patterns suggest that 5-15-min sessions and acute or single-session formats may be promising in several domains; these patterns do not establish an optimal active-break prescription. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Li, Chenmu AU - Li C AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. AD - School of Education, City University of Macau, Macau, China. FAU - Shangguan, Yuwen AU - Shangguan Y AD - Department of Sport and Exercise Sciences, Kunsan National University, Jeollabuk-Do, 54150, South Korea. FAU - Zhong, Zihao AU - Zhong Z AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Zhou, Rujia AU - Zhou R AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Wang, Hongyu AU - Wang H AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. AD - College of Physical Education and Health, Guangxi Normal University, Guilin, China. FAU - Li, Dong AU - Li D AUID- ORCID: 0009-0003-9861-0172 AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. Lidong58999@163.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review DEP - 20260824 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Executive Function/physiology MH - *Attention/physiology MH - Child MH - Adolescent MH - Cognitive Flexibility MH - *Exercise/psychology/physiology MH - Randomized Controlled Trials as Topic MH - Memory, Short-Term MH - Cognition MH - Schools OTO - NOTNLM OT - Active breaks OT - Adolescents OT - Attention OT - Children OT - Executive function OT - Meta-analysis COIS- Declarations. Ethics approval and consent to participate: Not applicable. This study is a systematic review and meta-analysis of published literature and does not involve any new studies with human participants performed by any of the authors. Therefore, ethical approval was not required. The review followed the PRISMA guidelines. Consent to participate: Not applicable. Consent for publication: Not applicable. Conflict of interest: The authors declare no competing interests. EDAT- 2026/08/24 18:42 MHDA- 2026/08/24 18:43 CRDT- 2026/08/24 11:17 PHST- 2026/05/20 00:00 [received] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/24 18:43 [medline] PHST- 2026/08/24 18:42 [pubmed] PHST- 2026/08/24 11:17 [entrez] AID - 10.1007/s00431-026-07341-3 [pii] AID - 10.1007/s00431-026-07341-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Aug 24;185(9):690. doi: 10.1007/s00431-026-07341-3. PMID- 42635550 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260827 IS - 2047-3095 (Electronic) IS - 2047-3087 (Print) IS - 2047-3087 (Linking) VI - 37 IP - 2 DP - 2026 Apr TI - Clinical validation of the nursing diagnosis of inadequate nutritional intake in children with cancer. PG - 274-282 LID - 10.1177/20473087261450939 [doi] AB - PurposeTo clinically validate the nursing diagnosis "Inadequate Nutritional Intake" based on elements identified within a specific situation theory framework in the context of children with cancer.MethodThis is a diagnostic accuracy study following the Standards for Reporting Diagnostic Accuracy Studies (STARD) protocol. Specifically, it refers to the clinical validation phase of the nursing diagnosis Inadequate nutritional intake, using a cross-sectional design. The study was conducted in a tertiary pediatric hospital with a sample of 69 children diagnosed with cancer.FindingsA total of 11 clinical indicators demonstrated diagnostic accuracy above 50%, including: ascites, low weight-for-age 77% sensitivity, 97% specificity, and 88% precision, outperforming the static method. This explainable data-driven framework improves data quality, transparency, and reproducibility, supporting scalable epidemiologic analyses using AI-ready dietary data. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. FAU - Massara, Paraskevi AU - Massara P AUID- ORCID: 0000-0003-0906-0985 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Saab, Stephanie AU - Saab S AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Asrar, Arooj AU - Asrar A AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Omand, Jessica AU - Omand J AUID- ORCID: 0000-0003-2095-3629 AD - School of Nutrition, Toronto Metropolitan University, Toronto, ON, Canada. FAU - Anderson, Laura N AU - Anderson LN AUID- ORCID: 0000-0002-6106-5073 AD - Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. FAU - Keown-Stoneman, Charles AU - Keown-Stoneman C AUID- ORCID: 0000-0001-8790-1589 AD - Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Maguire, Jonathon L AU - Maguire JL AUID- ORCID: 0000-0002-4083-8612 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, St. Michael's Hospital, Toronto, ON, Canada. AD - Joannah and Brian Lawson Center for Child Nutrition, University of Toronto, Toronto, ON, Canada. FAU - Bandsma, Robert H J AU - Bandsma RHJ AUID- ORCID: 0000-0001-6358-4750 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Translational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada. FAU - Birken, Catherine S AU - Birken CS AUID- ORCID: 0000-0003-0308-8645 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, St. Michael's Hospital, Toronto, ON, Canada. AD - Joannah and Brian Lawson Center for Child Nutrition, University of Toronto, Toronto, ON, Canada. FAU - Comelli, Elena M AU - Comelli EM AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Joannah and Brian Lawson Center for Child Nutrition, University of Toronto, Toronto, ON, Canada. LA - eng PT - Journal Article DEP - 20260824 PL - United States TA - Am J Epidemiol JT - American journal of epidemiology JID - 7910653 SB - IM OTO - NOTNLM OT - 24-hour dietary recall OT - AI-ready diet data OT - child and adult nutrition OT - data-driven outlier detection OT - longitudinal diet data EDAT- 2026/08/24 11:37 MHDA- 2026/08/24 11:37 CRDT- 2026/08/24 06:33 PHST- 2026/04/29 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/24 11:37 [medline] PHST- 2026/08/24 11:37 [pubmed] PHST- 2026/08/24 06:33 [entrez] AID - 8769274 [pii] AID - 10.1093/aje/kwag204 [doi] PST - aheadofprint SO - Am J Epidemiol. 2026 Aug 24:kwag204. doi: 10.1093/aje/kwag204. PMID- 42634659 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260824 LR - 20260825 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - Conicity Index and Other Anthropometric Indices in Relation to Visceral Fat Percentage in Adolescents with Overweight or Obesity: A Cross-Sectional Study. PG - e113293 LID - 10.7759/cureus.113293 [doi] LID - e113293 AB - Background Adolescent obesity is an increasing public health concern, particularly in South Asian populations where central adiposity and excess adiposity at relatively lower body mass index (BMI) are frequently observed. Visceral adiposity is a key determinant of cardiometabolic risk, but direct assessment using computed tomography or magnetic resonance imaging is impractical for routine clinical use. Anthropometric indices are therefore widely used as surrogate markers. The conicity index (CI), a composite measure incorporating waist circumference (WC), body weight, and height, has been proposed as an indicator of central fat distribution; however, its utility in overweight and obese adolescents remains uncertain. This study assessed the correlation between the CI and bioelectrical impedance analysis (BIA)-derived visceral fat percentage (VF%) in adolescents who are overweight and obese and compared its predictive performance with that of conventional anthropometric indices. Methods This hospital-based cross-sectional analytical study included 120 adolescents with overweight and obesity aged 10-19 years recruited by consecutive sampling from a tertiary care center in Maharashtra, India. Anthropometric indices, including BMI, WC, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), abdominal volume index (AVI), body adiposity index (BAI), and CI, were calculated using standard formulae. Body composition measurements, including VF%, were estimated using bioelectrical impedance analysis (Omron Karada Scan device, Omron Healthcare Co., Ltd., Kyoto, Japan). Because several variables were non-normally distributed, correlations were assessed using Spearman's rank correlation, and hierarchical multiple linear regression was used to identify independent predictors of VF%. Results The median age of participants was 13.0 years (IQR 10.8-15.0), with a balanced sex distribution. WC and AVI showed the strongest correlations with VF% (rho = 0.707 each, p < 0.001), followed by BMI (rho = 0.696, p < 0.001). WHtR and WHR showed moderate correlations, whereas the CI demonstrated only a weak correlation with VF% (rho = 0.267, p = 0.003). The CI was not significantly correlated with total body fat (BF%), subcutaneous fat (SCF), or fat mass index (FMI). In regression analysis, the base model including age, sex, and BMI explained 53.4% of the variance in VF%. Addition of WC significantly improved model performance (DeltaR(2) = 0.091, p < 0.001; final R(2) = 0.624), whereas addition of the CI provided a smaller improvement (DeltaR(2) = 0.049, p < 0.001). In the final model, BMI and WC were the only significant independent predictors. Conclusion The CI showed a statistically significant but weak correlation with VF% in this hospital-based cohort of adolescents who were overweight and obese, and its predictive performance was inferior to simpler measures, particularly BMI and WC. WC remains a practical and reliable anthropometric marker of central adiposity in this population. The CI may have a supplementary or research role but appears to provide limited additional value over conventional measures in this population. CI - Copyright (c) 2026, Kudlikar et al. FAU - Kudlikar, Kiran N AU - Kudlikar KN AD - Pediatrics, Mahatma Gandhi Mission (MGM) Medical College, MGM Institute of Health Sciences, Aurangabad, IND. FAU - Reddy, Vadde Y AU - Reddy VY AD - Pediatrics, Mahatma Gandhi Mission (MGM) Medical College, MGM Institute of Health Sciences, Aurangabad, IND. FAU - Siddiqui, Mohd Saeed AU - Siddiqui MS AD - Pediatrics, Mahatma Gandhi Mission (MGM) Medical College, MGM Institute of Health Sciences, Aurangabad, IND. FAU - Phatale, Priti AU - Phatale P AD - Pediatrics, Samrat Endocrine Institute for Diabetes, Obesity and Thyroid, Aurangabad, IND. FAU - Sangle, Avinash L AU - Sangle AL AD - Pediatrics, Mahatma Gandhi Mission (MGM) Medical College, MGM Institute of Health Sciences, Aurangabad, IND. FAU - Nelanuthala, Madhurasree AU - Nelanuthala M AD - Pediatrics, Mahatma Gandhi Mission (MGM) Medical College, MGM Institute of Health Sciences, Aurangabad, IND. FAU - Singh, Surya Pratap AU - Singh SP AD - Pediatrics, Mahatma Gandhi Mission (MGM) Medical College, MGM Institute of Health Sciences, Aurangabad, IND. FAU - Ahmed, Imtiyaz AU - Ahmed I AD - Pediatrics, Mahatma Gandhi Mission (MGM) Medical College, MGM Institute of Health Sciences, Aurangabad, IND. FAU - Chandranaik, Doreswamy AU - Chandranaik D AD - Pediatrics, Mahatma Gandhi Mission (MGM) Medical College, MGM Institute of Health Sciences, Aurangabad, IND. FAU - Bilala, Vandan R AU - Bilala VR AD - Pediatrics, Mahatma Gandhi Mission (MGM) Medical College, MGM Institute of Health Sciences, Aurangabad, IND. LA - eng PT - Journal Article DEP - 20260724 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13499985 OTO - NOTNLM OT - adolescent obesity OT - body mass index (bmi) OT - central obesity OT - conicity index OT - visceral adiposity OT - waist circumference (wc) COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Mahatma Gandhi Mission (MGM) Ethics Committee for Research on Human Subjects issued approval (MGM-ECRHS/2024/136; Dated: 30th March 2024). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/24 06:59 MHDA- 2026/08/24 05:35 PMCR- 2026/07/24 CRDT- 2026/08/24 03:36 PHST- 2026/07/24 00:00 [accepted] PHST- 2026/08/24 06:59 [pubmed] PHST- 2026/08/24 05:35 [medline] PHST- 2026/08/24 03:36 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.7759/cureus.113293 [doi] PST - epublish SO - Cureus. 2026 Jul 24;18(7):e113293. doi: 10.7759/cureus.113293. eCollection 2026 Jul. PMID- 42634399 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) VI - 62 IP - 10 DP - 2026 Oct TI - Early Mortality Risk Assessment in Preterm Neonates Using the Prognostic Nutritional Index. PG - 1995-2002 LID - 10.1111/jpc.70554 [doi] AB - BACKGROUND: Preterm neonates are at high risk of morbidity and mortality due to physiological immaturity and susceptibility to complications. The prognostic nutritional index (PNI), calculated from serum albumin and lymphocyte counts, is an inflammation-based biomarker widely used to predict prognosis in adult diseases. However, its role in neonatology remains unclear. OBJECTIVE: To evaluate the association between PNI and early mortality in preterm infants. METHODS: Preterm infants born at < 32 weeks of gestation and admitted to the neonatal intensive care unit were retrospectively analysed. Demographic, clinical and laboratory data were obtained from medical records. Infants who died within the first 7 days of life were defined as the mortality group and compared with survivors. PNI was calculated using lymphocyte and albumin levels measured within the first 24 h of life. Receiver operating characteristic (ROC) analysis was used to evaluate the predictive performance of PNI for early mortality, and multi-variable logistic regression analysis was performed to identify independent predictors. RESULTS: A total of 142 infants were included, of whom 17 (12%) died within the first 7 days. Gestational age, birth weight and Apgar scores were significantly lower in the mortality group, whereas maternal smoking was more frequent. PNI values were significantly lower in infants who died (p < 0.05). ROC analysis demonstrated an AUC of 0.703 for PNI in predicting early mortality with a cut-off value of 40 (sensitivity 77%, specificity 64%). Multi-variable logistic regression analysis identified low PNI (< 40) and gestational age as independent predictors of early mortality. CONCLUSION: PNI may serve as an adjunctive biomarker to complement established clinical predictors of early neonatal mortality in preterm infants. CI - (c) 2026 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Butun Turk, Seyma AU - Butun Turk S AUID- ORCID: 0000-0002-6304-4073 AD - Department of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Akin, Mustafa Senol AU - Akin MS AUID- ORCID: 0000-0003-0055-8277 AD - Department of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Sari, Fatma Nur AU - Sari FN AUID- ORCID: 0000-0003-4643-7622 AD - Department of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Alyamac Dizdar, Evrim AU - Alyamac Dizdar E AUID- ORCID: 0000-0001-8956-0917 AD - Department of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260823 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 RN - 0 (Biomarkers) RN - 0 (Serum Albumin) SB - IM MH - Humans MH - Infant, Newborn MH - Female MH - Retrospective Studies MH - *Infant, Premature MH - *Nutrition Assessment MH - Male MH - Risk Assessment/methods MH - Prognosis MH - *Infant Mortality MH - ROC Curve MH - Intensive Care Units, Neonatal MH - Biomarkers/blood MH - Gestational Age MH - Serum Albumin/analysis MH - Predictive Value of Tests OTO - NOTNLM OT - early mortality OT - inflammation OT - neonatal OT - preterm infants OT - prognostic nutritional index EDAT- 2026/08/24 06:59 MHDA- 2026/08/24 05:34 CRDT- 2026/08/24 02:23 PHST- 2026/08/03 00:00 [revised] PHST- 2026/05/01 00:00 [received] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/24 06:59 [pubmed] PHST- 2026/08/24 05:34 [medline] PHST- 2026/08/24 02:23 [entrez] AID - 10.1111/jpc.70554 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Oct;62(10):1995-2002. doi: 10.1111/jpc.70554. Epub 2026 Aug 23. PMID- 42633470 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260823 LR - 20260824 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - The Impact of Antenatal Lactation Counseling on Breastfeeding Practices and Newborn Feeding Behavior Among Primipara Mothers Attending a Tertiary Care Hospital in Puducherry, India: A Randomized Controlled Trial. PG - e113233 LID - 10.7759/cureus.113233 [doi] LID - e113233 AB - Introduction Although human milk provides unparalleled immunobiological and nutritional advantages essential for optimal neonatal development, the establishment of successful lactogenesis and sustained breastfeeding remains a complex psychophysiological challenge, particularly for primiparous mothers. First-time parturients frequently encounter biomechanical difficulties, such as suboptimal infant positioning and latch, which are compounded by postnatal anxiety. These factors can disrupt oxytocin-mediated milk let-down and precipitate disorganized neurobehavioral feeding reflexes in the newborn. Traditional postnatal lactation support is often reactive, administered during a period of high maternal fatigue and physiological stress. Therefore, structured antenatal lactation counseling emerges as a critical, proactive intervention designed to enhance maternal self-efficacy, provide anticipatory guidance, and mitigate the early introduction of prelacteal feeds. This randomized controlled trial (RCT) aimed to empirically validate this paradigm shift within a localized, high-volume clinical setting. It sought to investigate the effectiveness of targeted antenatal lactation counseling on both maternal breastfeeding practices and newborn feeding behaviors among primiparous mothers attending a tertiary care hospital in Puducherry, ultimately seeking to optimize perinatal care protocols through rigorous, evidence-based intervention. Methods An RCT was conducted with 130 primiparous women aged 18 to 35 years who had completed 32 weeks of gestation and delivered at term. A group counseling technique was used for the intervention group, wherein groups of five mothers received 30-minute antenatal lactation counseling sessions during antenatal visits. The lactation counseling on breastfeeding was repeated three times at 32, 34, and 36 weeks of gestation, while the control group received only routine care. Breastfeeding practices and newborn feeding behavior were assessed using a structured breastfeeding practices checklist and the Infant Breastfeeding Assessment Tool (IBFAT) on the second postnatal day. Results Baseline variables did not differ significantly between the groups. The intervention group showed significantly better breastfeeding practices (t = 5.384, p = 0.000) and newborn feeding behavior (t = 3.22, p = 0.02). Breast engorgement was lower in the intervention group, though the difference was not statistically significant. Conclusions Based on our findings, proper lactation counseling provided to primiparous mothers at each contact point during antenatal visits improves breastfeeding practices and promotes optimal newborn feeding behavior. CI - Copyright (c) 2026, Behera et al. FAU - Behera, Barsharani AU - Behera B AD - Obstetrics and Gynaecological Nursing, College of Nursing, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND. AD - Obstetrics and Gynaecology, Kalinga Institute of Nursing Sciences, Kalinga Institute of Industrial Technology (Deemed to be University), Bhubaneswar, IND. FAU - K, Kanimozhi AU - K K AD - Obstetrics and Gynaecological Nursing, College of Nursing, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND. FAU - Bethou, Adhisivam AU - Bethou A AD - Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND. LA - eng PT - Journal Article DEP - 20260723 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13499584 OTO - NOTNLM OT - breastfeeding practices OT - feeding behaviour. OT - lactation counselling OT - newborn OT - s: antenatal COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee (IEC) for Nursing Courses (Human Studies), JIPMER issued approval JIP/CON/IEC/M.Sc./2022/OBG/1. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/23 05:41 MHDA- 2026/08/23 05:42 PMCR- 2026/07/23 CRDT- 2026/08/23 04:19 PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/23 05:42 [medline] PHST- 2026/08/23 05:41 [pubmed] PHST- 2026/08/23 04:19 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.7759/cureus.113233 [doi] PST - epublish SO - Cureus. 2026 Jul 23;18(7):e113233. doi: 10.7759/cureus.113233. eCollection 2026 Jul. PMID- 42632822 OWN - NLM STAT- Publisher LR - 20260822 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Aug 22 TI - Association between triglyceride-glucose index and elevated blood pressure among U.S. adolescents aged 12-17. LID - 10.1038/s41390-026-05407-4 [doi] AB - BACKGROUND: The triglyceride-glucose (TyG) index is a known cardiovascular risk factor in adults, but its association with elevated blood pressure (EBP) in adolescents remains unclear. We hypothesized that the TyG index is associated with EBP among U.S. adolescents aged 12-17 years. METHODS: This cross-sectional analysis included 4409 adolescents from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. We used weighted multivariate logistic regression, weighted subgroup analysis, threshold effect and smoothing curve fitting to examine the association between the TyG index and EBP. RESULTS: Among the participants, 661 (14.9%) had EBP. After full adjustment, each unit rise in TyG index significantly boosted EBP odds (OR = 4.45, 95% CI 1.34-14.78, P = 0.02). A nonlinear relationship was observed, with an exploratory inflection point of the TyG index at 7.98. In BMI-stratified analyses, the association remained significant only among adolescents with BMI < 25 kg/m(2) (OR 3.09; 95%CI: 1.55-6.18; P < 0.01). Subgroup analyses revealed no significant interactions (all P for interaction >0.05). CONCLUSIONS: TyG index was cross-sectionally associated with EBP in U.S. 12-17-year-olds, with an exploratory inflection point. This suggests a potential low-cost indicator for risk stratification of adolescents with higher odds of EBP, pending verification in longitudinal studies. IMPACT: The triglyceride-glucose (TyG) index is cross-sectionally associated with elevated blood pressure (EBP) in U.S. 12-17-year-old adolescents, with an exploratory inflection point of 7.98. This study explores a TyG index exploratory inflection point for adolescent EBP risk in a nationally representative sample. TyG index, a routine and low-cost biomarker, presents potential utility for early risk stratification of adolescent EBP, although further prospective validation is required. The non-linear TyG index-EBP association highlights the potential need for age-specific metabolic risk stratification in adolescents. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Tang, Jiazhong AU - Tang J AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Shi, Yuexin AU - Shi Y AD - Department of Jinglang International Medical Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Jiao, Xianting AU - Jiao X AD - Department of Pediatric Infectious, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yang, Ling AU - Yang L AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Huang, Jihong AU - Huang J AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Huiying AU - Wang H AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 18221403205@163.com. LA - eng PT - Journal Article DEP - 20260822 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: NHANES was conducted with approval by the National Center for Health Statistics Ethics Review Board and obtained informed written consent from all the individuals involved in the study. EDAT- 2026/08/23 05:41 MHDA- 2026/08/23 05:41 CRDT- 2026/08/22 23:18 PHST- 2026/02/19 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/07/07 00:00 [revised] PHST- 2026/08/23 05:41 [medline] PHST- 2026/08/23 05:41 [pubmed] PHST- 2026/08/22 23:18 [entrez] AID - 10.1038/s41390-026-05407-4 [pii] AID - 10.1038/s41390-026-05407-4 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Aug 22. doi: 10.1038/s41390-026-05407-4. PMID- 42632660 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260822 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 242 IP - Pt 2 DP - 2026 Oct 31 TI - Urinary multi-mycotoxin exposure in the Portuguese population and associated sociodemographic determinants. PG - 119820 LID - S0963-9969(26)01504-8 [pii] LID - 10.1016/j.foodres.2026.119820 [doi] AB - European human biomonitoring (HBM) studies have increasingly adopted multi-mycotoxin approaches to capture complex exposure scenarios encountered in real-life diets. This nation-wide study provides the characterization, for the first time, of the mycotoxin profile of 295 urine samples collected from the Portuguese population in the continent and islands (archipelagos of Madeira and Azores), using an optimized and validated LC-MS/MS method for the characterization of 39 mycotoxins/metabolites. Nearly all study participants (99.3%) were exposed to at least one mycotoxin, with around half (54.2%) being co-exposed to only 2 detectable mycotoxins. Free-deoxynivalenol (free-DON, 84.7%) and tenuazonic acid (TeA, 95.6%) were the most prevalent mycotoxins. Citrinin (CIT, 11.5%), alpha-zearalenone (alpha-ZEL, 10.5%) and ochratoxin A (OTA, 9.5%) showed detection rates near 10%. Median concentrations (P50) for the two predominant mycotoxins were 0.79 mug/L (0.72 mug/g creatinine) for free-DON and 2.45 mug/L (2.08 mug/g creatinine) for TeA, with maximum values of 11.77 mug/L (10.06 mug/g creatinine) and 90.91 mug/L (114.15 mug/g creatinine), respectively. Sociodemographic patterns showed lower exposure in the Centre region and higher free-DON exposure in southern Portugal and the archipelagos. TeA exposure differed significantly by region and was lowest in the Lisbon Metropolitan Area and Algarve compared to the Center reference region. Low educational levels and spring sampling correlated with higher exposure for both toxins, but only education levels showed statistical significance in the linear regression analyses. For both TeA and free-DON, no differences in exposure were observed by sex, occupational status, or degree of urbanization. Overall, these findings underscore the importance of continuous surveillance, particularly under the current climate change scenario, and highlight the relevance of integrating human biomonitoring into national food safety and public health strategies. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Maris, Elias AU - Maris E AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium; Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium; Laboratory of Bioinformatics and (Eco-)Systems Biology, VIB Center for Microbiology, VIB, Leuven, Belgium. Electronic address: Elias.Maris@UGent.be. FAU - Namorado, Sonia AU - Namorado S AD - Department of Epidemiology, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal; NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisbon, Lisbon, Portugal. Electronic address: sonia.namorado@insa.min-saude.pt. FAU - Chen, An AU - Chen A AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. Electronic address: An.Chen@UGent.be. FAU - Pero-Gascon, Roger AU - Pero-Gascon R AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium; Department of Chemical Engineering and Analytical Chemistry, Institute for Research on Nutrition and Food Safety (INSA-UB), University of Barcelona, Spain. Electronic address: Roger.PeroGascon@UGent.be. FAU - De Boevre, Marthe AU - De Boevre M AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. Electronic address: Marthe.DeBoevre@UGent.be. FAU - De Saeger, Sarah AU - De Saeger S AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium; Department of Biotechnology and Food Technology, Faculty of Sciences, University of Johannesburg, South Africa. Electronic address: Sarah.DeSaeger@UGent.be. FAU - Silva, Maria Joao AU - Silva MJ AD - NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisbon, Lisbon, Portugal; Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal. Electronic address: m.joao.silva@insa.min-saude.pt. FAU - Alvito, Paula AU - Alvito P AD - Department of Food and Nutrition, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal; Centre for Environmental and Marine Studies (CESAM), University of Aveiro, Aveiro, Portugal. Electronic address: paula.alvito@insa.min-saude.pt. LA - eng PT - Journal Article DEP - 20260623 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 RN - 0 (Mycotoxins) SB - IM MH - Humans MH - Portugal MH - Female MH - Male MH - *Mycotoxins/urine MH - Adult MH - Biological Monitoring/methods MH - Middle Aged MH - Sociodemographic Factors MH - Young Adult MH - Tandem Mass Spectrometry MH - Aged MH - Adolescent MH - Environmental Exposure OTO - NOTNLM OT - Chemical exposure OT - Co-exposure OT - Exposome OT - Free-deoxynivalenol OT - Human biomonitoring OT - Mycotoxins OT - Portugal OT - Sociodemographic characteristics OT - Tenuazonic acid OT - Urine COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/22 23:43 MHDA- 2026/08/22 23:44 CRDT- 2026/08/22 20:53 PHST- 2026/03/12 00:00 [received] PHST- 2026/06/04 00:00 [revised] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/08/22 23:44 [medline] PHST- 2026/08/22 23:43 [pubmed] PHST- 2026/08/22 20:53 [entrez] AID - S0963-9969(26)01504-8 [pii] AID - 10.1016/j.foodres.2026.119820 [doi] PST - ppublish SO - Food Res Int. 2026 Oct 31;242(Pt 2):119820. doi: 10.1016/j.foodres.2026.119820. Epub 2026 Jun 23. PMID- 42631747 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Aug 22 TI - Assessing the psychological effects of eosinophilic esophagitis: a study on anxiety, self-concept, and depression in pediatric patients. LID - 689 [pii] LID - 10.1007/s00431-026-07350-2 [doi] AB - Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus that may impose a substantial psychological burden on affected children. Its impact on self-concept, anxiety, and depression has not been well characterized. This study aimed to investigate levels of self-concept, anxiety, and depression in children with EoE and to evaluate the psychological burden associated with the disease. Sixty-two children aged 6-18 years, including 31 patients with EoE and 31 controls without EoE, participated in the study. In the EoE group, psychological assessment was performed after at least 1 year of clinical follow-up and treatment; none of the patients were evaluated at the time of initial diagnosis. Psychological functioning was assessed using the Piers-Harris Children's Self-Concept Scale, the Screen for Child Anxiety Related Emotional Disorders (SCARED), and the Children's Depression Inventory (CDI), all validated in Turkish. Clinical characteristics, including symptom profile, disease duration, and medication use, were also recorded. The Mann-Whitney U-test was used for between-group comparisons. Children with EoE had significantly lower self-concept (Piers-Harris) scores and higher anxiety (SCARED) and depression (CDI) scores than controls (p < 0.001, p = 0.004, and p = 0.003, respectively). No significant associations were observed between psychological scores and general disease characteristics, including disease duration, medication use, or the presence of atopic comorbidities. CONCLUSION: Children with EoE demonstrated higher anxiety and depression scores and lower self-concept scores than controls despite having been followed and treated for at least 1 year before psychological assessment. These findings suggest that children with EoE may experience an increased psychological burden and support consideration of psychological assessment as part of multidisciplinary care. WHAT IS KNOWN: * Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease that can negatively affect quality of life through persistent symptoms, dietary restrictions, and repeated medical procedures. * Previous studies suggest that children with EoE may be at increased risk for anxiety and depression, but data remain limited, particularly in non-Western populations. WHAT IS NEW: * Turkish children with EoE showed significantly higher anxiety and depression scores and lower self-concept scores than healthy controls. * Feeding-related symptoms, particularly dysphagia and food impaction sensations, were associated with greater psychological distress, highlighting the need for routine psychological assessment in pediatric EoE care. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Ozkaya, Mehmet AU - Ozkaya M AUID- ORCID: 0000-0002-8101-9058 AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. dr.mehmetozk@gmail.com. FAU - Ozdamar, Emre AU - Ozdamar E AUID- ORCID: 0009-0002-0674-517X AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. FAU - Bayazit, Zehra AU - Bayazit Z AUID- ORCID: 0000-0002-5875-4599 AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. FAU - Erdogan, Burcu Ozge AU - Erdogan BO AUID- ORCID: 0000-0001-6859-0201 AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. FAU - Gul, Melike Kevser AU - Gul MK AUID- ORCID: 0000-0002-0907-4503 AD - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Erciyes University, Kayseri, Turkey. FAU - Tahan, Fulya AU - Tahan F AUID- ORCID: 0000-0002-8849-3422 AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. LA - eng PT - Journal Article DEP - 20260822 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - Female MH - *Self Concept MH - Adolescent MH - Male MH - *Eosinophilic Esophagitis/psychology/complications MH - *Anxiety/etiology/diagnosis MH - *Depression/etiology/diagnosis MH - Case-Control Studies MH - Turkey MH - Psychiatric Status Rating Scales OTO - NOTNLM OT - Anxiety OT - Child OT - Depression OT - Eosinophilic esophagitis OT - Psychological well-being OT - Self-concept COIS- Declarations. Ethical approval and informed consent: The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Erciyes University Ethics Committee (Approval No. 2023/691). Consent to participate: All participants provided informed consent prior to their inclusion in the study. Parents or guardians provided written consent for their child's participation in this study. Consent for publication: Not applicable. Competing interests: The authors have no relevant financial or non-financial interests to disclose. EDAT- 2026/08/22 22:41 MHDA- 2026/08/22 22:42 CRDT- 2026/08/22 11:04 PHST- 2026/06/03 00:00 [received] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/22 22:42 [medline] PHST- 2026/08/22 22:41 [pubmed] PHST- 2026/08/22 11:04 [entrez] AID - 10.1007/s00431-026-07350-2 [pii] AID - 10.1007/s00431-026-07350-2 [doi] PST - epublish SO - Eur J Pediatr. 2026 Aug 22;185(9):689. doi: 10.1007/s00431-026-07350-2. PMID- 42630878 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260822 LR - 20260824 IS - 2694-250X (Electronic) IS - 2694-250X (Linking) VI - 6 IP - 4 DP - 2026 Aug 19 TI - A Single-Enzyme Electrochemical Biosensor for Lactose Detection in Human Breastmilk and Dairy Products. PG - 949-956 LID - 10.1021/acsmeasuresciau.5c00207 [doi] AB - Lactose, a disaccharide found predominantly in human breast milk and dairy products, plays a vital role in human health and nutrition. While lactose is an essential energy source particularly for infant growth, it is also a biomarker of low milk production in breastfeeding women. Furthermore, lactose intolerance affects a substantial portion of the global population, impacting the quality of life. Therefore, the ability to detect and quantify lactose is important as a biomarker for both milk production and nutritional content. Here, we report on the development of a single-enzyme electrochemical biosensor for lactose employing lactose oxidase (LOx), which converts lactose to lactobionic acid and hydrogen peroxide. The sensor showed high specificity, achieving a limit of detection of 1.4 muM. The analytical performance of the sensor was verified in human breast milk as well as bovine milk. This approach allows for a rapid, reliable, and potentially portable platform for lactose detection, making it ideal for both clinical applications and routine controls in the food industry. CI - (c) 2026 The Authors. Published by American Chemical Society. FAU - Sanchez-Salcedo, Raquel AU - Sanchez-Salcedo R AUID- ORCID: 0000-0002-5335-1088 AD - Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. RINGGOLD: 2541 AD - Melbourne Centre for Nanofabrication, Victorian Node of the Australian National Fabrication Facility, Clayton, Victoria 3168, Australia. AD - Australian Research Council Training Centre for Next-Gen Biomedical Analysis, Perth, Western Australia 6009, Australia. FAU - Geddes, Donna T AU - Geddes DT AD - Australian Research Council Training Centre for Next-Gen Biomedical Analysis, Perth, Western Australia 6009, Australia. AD - School of Molecular Science, The University of Western Australia, Perth, Western Australia 6009, Australia. AD - UWA Centre for Human Lactation Research and Translation, The University of Western Australia, Crawley, Perth, Western Australia 6009, Australia. FAU - Voelcker, Nicolas H AU - Voelcker NH AUID- ORCID: 0000-0002-1536-7804 AD - Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. RINGGOLD: 2541 AD - Melbourne Centre for Nanofabrication, Victorian Node of the Australian National Fabrication Facility, Clayton, Victoria 3168, Australia. AD - Australian Research Council Training Centre for Next-Gen Biomedical Analysis, Perth, Western Australia 6009, Australia. AD - Materials Science and Engineering, Monash University, Clayton, Victoria 3168, Australia. LA - eng PT - Journal Article DEP - 20260318 PL - United States TA - ACS Meas Sci Au JT - ACS measurement science au JID - 9918232604306676 PMC - PMC13495733 OTO - NOTNLM OT - dairy products OT - electrochemical sensor OT - human breast milk OT - lactose detection OT - point-of-care diagnostics OT - single-enzyme sensing platform EDAT- 2026/08/22 22:41 MHDA- 2026/08/22 22:42 PMCR- 2026/03/18 CRDT- 2026/08/22 05:56 PHST- 2025/12/18 00:00 [received] PHST- 2026/03/07 00:00 [revised] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/08/22 22:42 [medline] PHST- 2026/08/22 22:41 [pubmed] PHST- 2026/08/22 05:56 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - 10.1021/acsmeasuresciau.5c00207 [doi] PST - epublish SO - ACS Meas Sci Au. 2026 Mar 18;6(4):949-956. doi: 10.1021/acsmeasuresciau.5c00207. eCollection 2026 Aug 19. PMID- 42630056 OWN - NLM STAT- Publisher LR - 20260822 IS - 1708-8283 (Electronic) IS - 0883-0738 (Linking) DP - 2026 Aug 21 TI - The Effects of Aerobic Exercise on Pediatric Headache-Related Disability and Quality of Life: A Pilot Randomized Controlled Trial. PG - 8830738261476485 LID - 10.1177/08830738261476485 [doi] AB - This pilot randomized-controlled trial aimed to evaluate the impact of aerobic exercise on (1) headache-related disability, via the Pediatric Migraine Disability Assessment Scale, and (2) quality of life, via the Pediatric Quality of Life Inventory and KIDSCREEN-27. Participants (8-17 years of age) were randomized at an initial 1:1 ratio revised to 2:1 to a 4-week at-home program of daily aerobic exercise or stretching. Nineteen participants (89% female, mean age = 14.3 +/- 2.2 years) completed the study. There were clinically meaningful differences in headache-related disability in both groups from baseline to post-study (standardized mean change, Hedges' g, in aerobic exercise group: 0.53 [95% CI: -0.29, 1.35]; stretching group: 0.71 [95% CI: -0.27, 1.66]), but no differences in quality of life (P values ranging from 0.06 to 1.00 across all domains). When considered alongside the broader health benefits of exercise documented elsewhere, our findings represent a preliminary signal warranting further investigation of exercise training as a potential care pathway for pediatric headache. Given our limited sample size, these findings should be interpreted with caution, and alone are insufficient to inform clinical recommendations. This study was limited by poor enrollment over 5 years and higher rates of drop-out in the aerobic exercise group. Future studies should seek to define and overcome feasibility barriers associated with exercise-based interventions. FAU - Artna, Erin AU - Artna E AUID- ORCID: 0000-0001-6829-1797 AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 AD - Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. AD - Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada. FAU - Reddy, Deepti AU - Reddy D AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 FAU - Chen, Kitty AU - Chen K AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 FAU - Longmuir, Patricia E AU - Longmuir PE AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 AD - Faculty of Medicine, University of Ottawa, Ottawa, Canada. AD - Faculty of Health Sciences, University of Ottawa, Ottawa, Canada. FAU - Pohl, Daniela AU - Pohl D AUID- ORCID: 0000-0002-2996-7210 AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 AD - Faculty of Medicine, University of Ottawa, Ottawa, Canada. AD - Division of Neurology, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada. LA - eng PT - Journal Article DEP - 20260821 PL - United States TA - J Child Neurol JT - Journal of child neurology JID - 8606714 SB - IM OTO - NOTNLM OT - disability OT - exercise OT - migraine OT - pediatric OT - quality of life EDAT- 2026/08/22 05:37 MHDA- 2026/08/22 05:37 CRDT- 2026/08/22 02:53 PHST- 2026/08/22 05:37 [medline] PHST- 2026/08/22 05:37 [pubmed] PHST- 2026/08/22 02:53 [entrez] AID - 10.1177/08830738261476485 [doi] PST - aheadofprint SO - J Child Neurol. 2026 Aug 21:8830738261476485. doi: 10.1177/08830738261476485. PMID- 42628484 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261009 IS - 1528-3984 (Electronic) IS - 0197-4572 (Linking) VI - 73 DP - 2026 Oct TI - Co-creating an intergenerational intervention to enhance physical activity in the older adult population: A qualitative study of the engAGE project. PG - 104280 LID - S0197-4572(26)00485-4 [pii] LID - 10.1016/j.gerinurse.2026.104280 [doi] AB - BACKGROUND: Older adults are the most sedentary population segment, and effective, sustainable interventions are needed to modify these behaviours. Intergenerational and participatory approaches may enhance adherence and support long-term engagement. This study reports on the co-creation of an intergenerational intervention to promote physical activity (PA) and social interaction among older adults. It also explores the potential of virtual reality (VR) to support uptake and adherence. METHODS: A mixed-methods design was applied, guided by the Health CASCADE framework and the Behaviour Change Wheel (BCW). The intervention was co-created with older adults, children, teachers, professionals, and policymakers. The qualitative components included expert interviews, workshops with older adults and children, and an advisory board workshop. An online survey with older adults explored willingness to participate, perceived acceptability and relevance, adaptation to their needs, and suggestions for improvement. RESULTS: Four themes informed the intervention: (1) building on prior experiences with technology; (2) designing with empathy to ensure safety, enjoyment, and adaptability; (3) valuing intergenerational engagement; and (4) aligning with older adults' priorities. Workshops with 26 older adults (84.1 +/- 7.6 years) and nineteen children (11.5 +/- 2.9 years) highlighted shared preference for outdoor activities. Findings were translated into an intervention proposal during the advisory board workshop. Survey results from 53 older adults showed that 67.9% were willing to participate. CONCLUSIONS: Co-creation is a feasible approach to developing inclusive intergenerational PA interventions. Outdoor activities were widely preferred, while VR may potentially support motivation when implemented with attention to accessibility, user acceptance, and gradual integration. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Paredes-Vargas, X AU - Paredes-Vargas X AD - Universitat Ramon Llull, School of Psychology, Education and Sport Sciences Blanquerna, Barcelona, Spain. Electronic address: jodieximenapv@blanquerna.url.edu. FAU - Trull, R AU - Trull R AD - Universitat Ramon Llull, School of Psychology, Education and Sport Sciences Blanquerna, Barcelona, Spain. FAU - Sola, J AU - Sola J AD - Universitat Ramon Llull, School of Psychology, Education and Sport Sciences Blanquerna, Barcelona, Spain. FAU - Fort-Vanmeerhaeghe, A AU - Fort-Vanmeerhaeghe A AD - Universitat Ramon Llull, School of Psychology, Education and Sport Sciences Blanquerna, Barcelona, Spain. FAU - Martin, L AU - Martin L AD - Universitat Ramon Llull, School of Psychology, Education and Sport Sciences Blanquerna, Barcelona, Spain. FAU - Jerez-Roig, Javier AU - Jerez-Roig J AD - University of Vic-Central University of Catalonia (UVic-UCC), Faculty of Health Sciences and Welfare, Research group on Methodology, Methods, Models and Outcomes of Health and Social Sciences (M3O), Vic, Catalunya, Spain; Institute for Research and Innovation in Life Sciences and Health in Central Catalonia (IRIS-CC), Vic, Spain; Lithuanian Sports University, Department of Health Promotion and Rehabilitation, Institute of Sport Science and Innovations, Kaunas, Lithuania. FAU - Capella, I AU - Capella I AD - Broomx Technologies - Immersive VR Company / Manifiesto Studio SL, Barcelona, Spain. FAU - Cardon, G AU - Cardon G AD - Ghent University, Department of Movement and Sports Sciences, Ghent, Belgium. FAU - Gine-Garriga, M AU - Gine-Garriga M AD - Universitat Ramon Llull, School of Psychology, Education and Sport Sciences Blanquerna, Barcelona, Spain; Universitat Ramon Llull, School of Health Sciences Blanquerna, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260821 PL - United States TA - Geriatr Nurs JT - Geriatric nursing (New York, N.Y.) JID - 8309633 SB - IM MH - Humans MH - Aged MH - *Exercise/psychology MH - Female MH - *Intergenerational Relations MH - Qualitative Research MH - *Health Promotion/methods MH - Male MH - Aged, 80 and over MH - Social Interaction MH - Surveys and Questionnaires MH - Virtual Reality OTO - NOTNLM OT - Ageing OT - Immersive technology OT - Intergenerational OT - Movement OT - Social interactions COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Maria reports financial support was provided by Spain Ministry of Science and Innovation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/21 23:37 MHDA- 2026/10/09 05:30 CRDT- 2026/08/21 18:10 PHST- 2025/10/06 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/10/09 05:30 [medline] PHST- 2026/08/21 23:37 [pubmed] PHST- 2026/08/21 18:10 [entrez] AID - S0197-4572(26)00485-4 [pii] AID - 10.1016/j.gerinurse.2026.104280 [doi] PST - ppublish SO - Geriatr Nurs. 2026 Oct;73:104280. doi: 10.1016/j.gerinurse.2026.104280. Epub 2026 Aug 21. PMID- 42628000 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260914 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Aug 21 TI - Mental Health, Gender Dysphoria, and Quality of Life in Trans Individuals Following Top Surgery: Protocol for a Prospective Cohort Study. PG - e83928 LID - 10.2196/83928 [doi] LID - e83928 AB - BACKGROUND: Top surgery refers to various gender-affirming surgical procedures involving breast or chest tissue. Existing research suggests top surgery improves physical, psychological, and social well-being in transgender and gender-diverse individuals (herein "trans") who desire it. However, most studies have been retrospective, have not used validated outcome measures, and have excluded nonbinary individuals, limiting the robustness of the existing research. OBJECTIVE: This study aims to examine changes in mental health, gender dysphoria, risky behaviors, and quality of life of trans people (including nonbinary individuals) following top surgery. METHODS: Trans individuals aged 16 years and older undergoing top surgery will be recruited from a single surgeon's office in Perth, Western Australia, as part of a longitudinal, prospective cohort study. Questionnaires will be administered to participants at 3 time points: within 8 weeks prior to surgery, 6-8 weeks post surgery, and 1 year post surgery. These questionnaires will collect data on patient demographics, planning and expectations for surgery, support received during surgery access, satisfaction with care received from their surgeon, use of gender-affirming hormones, mental health (ie, anxiety, depression, self-harm and suicide, and mental health diagnoses), gender euphoria and dysphoria, exercise and diet, disordered eating, quality of life, substance use, social acceptance and discrimination, and reflections on the experience and outcomes of their surgery. Patient-reported outcomes will be measured using validated instruments and bespoke items developed through community consultation. Validated instruments include the GENDER-Q (health professional subscale); the Generalized Anxiety Disorder 7-item; the Patient Health Questionnaire-9; the Gender Euphoria Scale; an adapted version of the Olson-Kennedy Chest Dysphoria Scale; the International Physical Activity Questionnaire - Short Form; the Eating Disorder Examination Questionnaire - Short; the Assessment of Quality of Life 8 Dimensions; and the Alcohol, Smoking, and Substance Involvement Screening Test - Short Form. Surgical satisfaction will be assessed using both patient- and surgeon-reported measures, enabling between-group comparisons. Quantitative data will be analyzed using linear regression models and repeated-measures ANOVA to compare outcomes across the 3 time points; qualitative data will undergo a general inductive approach to analysis to produce categories that contextualize and supplement the quantitative findings, as well as identify any novel or unexpected experiences. RESULTS: This study received funding in February 2024. Data collection commenced in May 2025 and is expected to be completed by December 2027. As of February 2026, 26 people have consented to participate. CONCLUSIONS: This study will extend research on the mental health, gender dysphoria, and quality-of-life outcomes of top surgery for trans individuals in Australia. By addressing limitations of existing research, this study aims to improve our understanding of trans people's experience accessing and receiving top surgery. The findings may guide improvements in perioperative and postoperative care and support for patients and inform policy related to gender-affirming surgeries in Australia. CI - (c) Julia Bak, Kah Aik Tan, Jack Ball, Sam Bonney, Julia K Moore, Kirsty Hird, Blake S Cavve, Larissa Marion, Tim Hewitt, Sav Zwickl, Simone Mahfouda, Ashleigh Lin, Penelope Strauss. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Bak, Julia AU - Bak J AUID- ORCID: 0009-0005-6822-534X AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Tan, Kah Aik AU - Tan KA AUID- ORCID: 0000-0002-3053-7154 AD - South Metropolitan Health Service - Mental Health, Fiona Stanley Hospitals Group, Perth, Australia. AD - East Metropolitan Health Service - Mental Health, Royal Perth Bentley Hospitals Group, Perth, Australia. FAU - Ball, Jack AU - Ball J AUID- ORCID: 0009-0006-4726-3723 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Bonney, Sam AU - Bonney S AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Moore, Julia K AU - Moore JK AUID- ORCID: 0000-0002-2313-7048 AD - The Gender Diversity Service, Child and Adolescent Health Service - Mental Health, Perth Children's Hospital, Perth, Australia. FAU - Hird, Kirsty AU - Hird K AUID- ORCID: 0000-0001-7677-2128 AD - The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia. FAU - Cavve, Blake S AU - Cavve BS AUID- ORCID: 0000-0002-3548-6181 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Marion, Larissa AU - Marion L AUID- ORCID: 0000-0002-8244-6588 AD - School of Psychological Science, The University of Western Australia, Perth, Australia. FAU - Hewitt, Tim AU - Hewitt T AUID- ORCID: 0009-0003-0989-9470 AD - Fellow of the Royal Australasian College of Surgeons, Perth, Australia. AD - Child and Adolescent Health Service, Perth Children's Hospital, Perth, Australia. FAU - Zwickl, Sav AU - Zwickl S AUID- ORCID: 0000-0003-2959-5928 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. AD - Department of Medicine (Austin Health), Trans Health Research Group, The University of Melbourne, Perth, Australia. FAU - Mahfouda, Simone AU - Mahfouda S AUID- ORCID: 0000-0002-1501-3926 AD - Department of Clinical Psychology, Acute Adult Inpatient Services, Graylands Hospital, Perth, Australia. FAU - Lin, Ashleigh AU - Lin A AUID- ORCID: 0000-0002-4054-0242 AD - School of Population and Global Health, The University of Western Australia, Perth, Australia. AD - Australian Research Centre in Sex, Health and Society, La Trobe University, Melbourne, Australia. FAU - Strauss, Penelope AU - Strauss P AUID- ORCID: 0000-0002-4828-0983 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. AD - School of Population and Global Health, The University of Western Australia, Perth, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260821 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Male MH - *Quality of Life/psychology MH - Female MH - *Gender Dysphoria/psychology MH - Prospective Studies MH - *Transgender Persons/psychology MH - *Mental Health MH - Surveys and Questionnaires MH - Adult MH - *Gender-Affirming Surgery/psychology MH - Adolescent MH - Western Australia MH - Longitudinal Studies MH - Gender-Nonconforming Persons PMC - PMC13496940 OTO - NOTNLM OT - chest reconstruction OT - gender affirmation OT - gender dysphoria OT - top surgery OT - transgender COIS- Conflicts of Interest: TH is a surgeon who performs top surgery in Western Australia and is a recruitment site for this study. TH contributed to the study design primarily through co-developing the surgical pro formas and informing on the ideal timing of questionnaire delivery for participants. TH will be aware of the identity of participants as he will complete the surgical pro formas for participants. However, TH will not have access to the raw data collected through the participant questionnaires, to preserve participant privacy and ensure that participants feel free to answer the questionnaires freely. EDAT- 2026/08/21 17:37 MHDA- 2026/08/21 17:38 PMCR- 2026/08/21 CRDT- 2026/08/21 15:53 PHST- 2025/09/10 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/08/21 17:38 [medline] PHST- 2026/08/21 17:37 [pubmed] PHST- 2026/08/21 15:53 [entrez] PHST- 2026/08/21 00:00 [pmc-release] AID - v15i1e83928 [pii] AID - 83928 [pii] AID - 10.2196/83928 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Aug 21;15:e83928. doi: 10.2196/83928. PMID- 42627606 OWN - NLM STAT- Publisher LR - 20260821 IS - 1720-8386 (Electronic) IS - 0391-4097 (Linking) DP - 2026 Aug 21 TI - Interpreting the GnRH stimulation test in girls with central precocious puberty: the role of age and body mass index. LID - 10.1007/s40618-026-03027-7 [doi] AB - PURPOSE: The gonadotropin-releasing hormone (GnRH) stimulation test is the reference standard for diagnosing central precocious puberty (CPP), yet its reliability may vary with age and body mass index (BMI). This study evaluated the diagnostic performance of GnRH test parameters in girls with suspected CPP and examined the influence of age and BMI on their clinical interpretation. METHODS: This retrospective study included 98 girls who underwent GnRH stimulation testing between January 2023 and December 2025 at a tertiary pediatric endocrinology center. Auxological data, basal luteinizing hormone (LH), stimulated LH at 40 min (LH(4)(0)), stimulated LH/FSH ratio (sLH/FSH), bone age advancement (BAA), and pelvic ultrasonographic measurements were recorded. Final CPP diagnosis based on longitudinal follow-up served as the reference outcome. ROC analyses, age- and BMI-stratified evaluations, and multivariable logistic regression were performed. RESULTS: Thirty-six girls (36.7%) were diagnosed with CPP, and all initiated GnRHanalogue treatment. LH(4)(0) showed the highest diagnostic performance (AUC = 0.738); a cut-off of 4.65 IU/L yielded 91.2% sensitivity and 61.7% specificity. Basal LH had limited accuracy (AUC = 0.668), and ultrasonographic parameters showed poor discrimination. LH(4)(0) and BAA were independently associated with CPP. Diagnostic performance varied by age, with excellent discrimination in girls < 6 years (AUC = 1.000) and moderate accuracy at 6-8 years (AUC = 0.738). Increasing BMI was associated with reduced discriminatory capacity of LH(4)(0), while uterine length showed relatively higher performance in girls with obesity. CONCLUSION: The diagnostic performance of the GnRH stimulation test varied with age and BMI and was lower in older girls and those with obesity. LH(4)(0) was the most informative hormonal parameter, but should not be interpreted in isolation. Test results should be integrated with clinical progression, auxological findings, skeletal maturation, biochemical data, and imaging when clinically indicated. CI - (c) 2026. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE). FAU - Hurmuzlu Kozler, Selen AU - Hurmuzlu Kozler S AUID- ORCID: 0000-0001-6533-2944 AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. selenhurmuzlu@gmail.com. FAU - Kilci, Fatih AU - Kilci F AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. FAU - Sarikaya, Emre AU - Sarikaya E AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. FAU - Ozcan Murat, Nurhan AU - Ozcan Murat N AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. LA - eng PT - Journal Article DEP - 20260821 PL - Italy TA - J Endocrinol Invest JT - Journal of endocrinological investigation JID - 7806594 SB - IM OTO - NOTNLM OT - Body mass index OT - Central precocious puberty OT - Diagnostic performance OT - GnRH stimulation test OT - Luteinizing hormone OT - Pelvic ultrasonography COIS- Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Kocaeli City Hospital (No:2026/27). Informed consent: was waived due to the use of anonymized retrospective data. EDAT- 2026/08/21 17:37 MHDA- 2026/08/21 17:37 CRDT- 2026/08/21 11:18 PHST- 2026/06/13 00:00 [received] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/08/21 17:37 [medline] PHST- 2026/08/21 17:37 [pubmed] PHST- 2026/08/21 11:18 [entrez] AID - 10.1007/s40618-026-03027-7 [pii] AID - 10.1007/s40618-026-03027-7 [doi] PST - aheadofprint SO - J Endocrinol Invest. 2026 Aug 21. doi: 10.1007/s40618-026-03027-7. PMID- 42627241 OWN - NLM STAT- Publisher LR - 20260831 IS - 1531-698X (Electronic) IS - 1040-8703 (Linking) DP - 2026 Aug 31 TI - From Jones to avulsion: rethinking the fifth metatarsal base. LID - 10.1097/MOP.0000000000001615 [doi] AB - PURPOSE OF REVIEW: Fifth metatarsal fractures are the most common metatarsal injury in the pediatric population; however, their management is frequently extrapolated from adult protocols. This review explores the emergence of pediatric-specific classification systems and evolving evidence on surgical versus conservative treatment in skeletally immature patients. RECENT FINDINGS: Anatomical and developmental differences critically distinguish pediatric fractures from adult fractures. Recent pediatric classifications, including those by Herrera-Soto and Lee, improve upon the widely used Dameron/Lawrence-Botte system by recognizing the apophysis as a distinct entity and offering better prognostic correlation. Zone 1 avulsion fractures achieve near-universal healing with conservative management. Emerging evidence supports surgical fixation with intramedullary screws for Zone 2 (Jones) fractures in adolescent athletes, whereas prepubertal patients respond well to conservative treatment. Nutritional factors, particularly vitamin D deficiency and inadequate calcium intake, are increasingly being recognized as modifiable risk factors for stress fractures and delayed union. SUMMARY: The management of fifth metatarsal fractures should be individualized according to the fracture zone, skeletal maturity, and activity level. Pediatric-specific classifications offer improved diagnostic accuracy. Nutritional optimization should be integrated into comprehensive management protocols, and further pediatric-focused clinical trials are needed. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Sepulveda, Matias AU - Sepulveda M AD - Universidad Austral de Chile. AD - Hospital Base de Valdivia. AD - Clinica Alemana Valdivia, Valdivia, Chile. FAU - Gutierrez, Gabriel AU - Gutierrez G AD - Hospital Base de Valdivia. AD - Clinica Alemana Valdivia, Valdivia, Chile. FAU - Birrer, Estefania AU - Birrer E AD - Universidad Austral de Chile. AD - Hospital Base de Valdivia. AD - Clinica Alemana Valdivia, Valdivia, Chile. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - Curr Opin Pediatr JT - Current opinion in pediatrics JID - 9000850 SB - IM OTO - NOTNLM OT - Jones fracture OT - apophysis OT - avulsion fracture OT - fifth metatarsal fracture OT - pediatric fracture EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:39 CRDT- 2026/08/21 10:03 PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 11:39 [medline] PHST- 2026/08/21 10:03 [entrez] AID - 00008480-990000000-00389 [pii] AID - 10.1097/MOP.0000000000001615 [doi] PST - aheadofprint SO - Curr Opin Pediatr. 2026 Aug 31. doi: 10.1097/MOP.0000000000001615. PMID- 42626294 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260926 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Hunger, satiety, and eating behavior after craniopharyngioma - narrative review on current management and future therapeutic perspectives. PG - 1895026 LID - 10.3389/fendo.2026.1895026 [doi] LID - 1895026 AB - Craniopharyngiomas are low-grade, intracranial tumors frequently associated with dysfunction of the hypothalamic-pituitary axes and the development of obesity. This narrative review aimed to evaluate the potential contribution of eating behaviors, while also identifying perspectives for future therapeutic intervention. Searches were performed across five bibliographic databases. All peer-reviewed published studies involving childhood-onset or adult-onset craniopharyngioma populations were considered eligible when they examined eating behavior in relation to pharmacological or surgical interventions, neuroimaging, endocrine responses, energy expenditure, sleep, and/or neuropsychological outcomes. The available evidence regarding eating behavior in individuals with craniopharyngioma was limited, with only 10 of the 82 included studies employing validated measures of eating behavior. Eating behavior was assessed as a primary outcome in seven studies, as a secondary outcome in twelve studies, and discussed without formal measurement in thirty-one studies. Only one randomized controlled trial with the melanocortin-4 receptor (MC4R) agonist setmelanotide was identified that successfully targeted eating behavior (hyperphagia) modification and achieved significant weight loss as an intervention for craniopharyngioma-related obesity. Greater insight into eating behavior in this population, supported by long-term studies using validated assessment tools, is required to clarify the mechanisms underlying craniopharyngioma-associated obesity and confirm effectiveness and tolerability of medical treatment with MC4R-agonists. CI - Copyright (c) 2026 Muller. FAU - Muller, Hermann L AU - Muller HL AD - Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Carl von Ossietzky Universitat, Klinikum Oldenburg AoR, Oldenburg, Germany. LA - eng PT - Journal Article PT - Review DEP - 20260806 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Craniopharyngioma/therapy/complications/physiopathology MH - *Pituitary Neoplasms/therapy/complications/physiopathology MH - *Feeding Behavior/physiology MH - *Hunger/physiology MH - *Satiation/physiology MH - Obesity/etiology PMC - PMC13491036 OTO - NOTNLM OT - craniopharyngioma OT - eating behavior OT - hunger OT - hypothalamus OT - obesity OT - quality of life OT - satiety OT - setmelanotide COIS- HM has received reimbursement of participation fees for scientific meetings and continuing medical education events, and reimbursement of travel expenses and lecture honoraria from Rhythm Pharmaceuticals. HM is specialty chief editor for the journal Frontiers in Endocrinology - Pituitary Endocrinology, guest associate editor for Frontiers Obesity and Frontiers Pediatric Endocrinology, and editorial board member of biomedicines mdpi. The author HM declared that he was an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 06:02 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 06:02 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fendo.2026.1895026 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 6;17:1895026. doi: 10.3389/fendo.2026.1895026. eCollection 2026. PMID- 42626224 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260910 IS - 2219-2808 (Print) IS - 2219-2808 (Electronic) IS - 2219-2808 (Linking) VI - 15 IP - 3 DP - 2026 Sep 9 TI - Association of Helicobacter pylori infection with insulin resistance, tumor necrosis factor-alpha, and dyslipidemia in obese children with metabolic syndrome. PG - 121926 LID - 10.5409/wjcp.v15.i3.121926 [doi] LID - 121926 AB - BACKGROUND: Previous studies have suggested a link between Helicobacter pylori (H. pylori) and metabolic complications outside the gastrointestinal tract, but the relationship with pediatric obesity remains unclear. We aim to study the correlation between H. pylori infection and components of insulin resistance (IR), inflammation [tumor necrosis factor-alpha (TNF-alpha)], and cardiometabolic parameters in obese children/adolescents with a metabolic syndrome (MetS) phenotype. AIM: To elucidate the association between H. pylori infection and metabolic disturbances in children with obesity and MetS, focusing on homeostasis model assessment of IR (HOMA-IR), inflammatory markers (TNF-alpha), and the lipid profile. METHODS: The study recruited 70 obese children/adolescents with MetS phenotype from the pediatric units of Minia University Hospital from September 2023 to October 2024. H. pylori stool antigen quantitative enzyme-linked immunosorbent assay was used to classify participants into H. pylori-negative (n = 35) and H. pylori-positive (n = 35). Assessment of fasting glucose, glycated hemoglobin (HbA1c), fasting insulin, lipid profile, liver enzymes, TNF-alpha, adiponectin, and leptin, as well as other parameters, was done. IR was calculated in detail using the HOMA-IR formula (fasting insulin x fasting glucose/405). Various statistical analyses, including intergroup comparisons, correlation analyses, and receiver operating characteristic curve analyses, were also performed. RESULTS: Groups were similar in age, sex, and standardized body mass index (BMI) value. Elevated blood pressure (65.7% vs 31.4%, P = 0.004) and hepatomegaly (62.9% vs 28.6%, P = 0.004) were more common in H. pylori-positive participants. The infected group had higher alanine aminotransferase and aspartate aminotransferase (AST) levels (both P < 0.001). It had higher triglycerides and low-density lipoprotein cholesterol and lower high-density lipoprotein cholesterol (HDL) levels, indicating a more unfavorable lipid profile (all P < 0.001) and more impaired glycemic/IR indices: Fasting glucose (158.5 +/- 40.1 mg/dL vs 109.5 +/- 22.7 mg/dL, P < 0.001), HbA1c (8.5 +/- 2.2 vs 7.4 +/- 1.7, P = 0.019), fasting insulin (9.4 +/- 3.6 muIU/mL vs 3.9 +/- 1.0 muIU/mL, P < 0.001), and HOMA-IR (3.61 +/- 1.45 vs 1.06 +/- 0.36, P < 0.001). TNF-alpha was elevated in the infected group (median 7.13 vs 6.23, P = 0.011). In H. pylori-positive participants, HOMA-IR had a strong positive correlation with standardized BMI value (r = 0.889, P < 0.001) and TNF-alpha (r = 0.896, P < 0.001). HOMA-IR > 1.67 had excellent sensitivity and specificity for detecting H. pylori positivity [area under the curve (AUC): 0.954; sensitivity 88.6%, specificity 97.1%], and TNF-alpha had moderate sensitivity (AUC: 0.677). CONCLUSION: H. pylori positivity was linked to elevated IR, TNF-alpha, atherogenic dyslipidemia, and a greater hepatic/clinical metabolic burden in the MetS phenotype of obesity in children and adolescents. More longitudinal studies that will help control socioeconomic and lifestyle confounding are warranted. CI - (c)Author(s) 2026. FAU - Ibrahim Elbakry, Noura M AU - Ibrahim Elbakry NM AD - Department of Pediatric, Faculty of Medicine, Minia University, Minia 2422998, Egypt. FAU - Hemeda, Mohamed S AU - Hemeda MS AD - Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Port Said University, Port Said 44654, Egypt. mohamudsadawy@med.psu.edu.eg. FAU - Mostafa Mohamed Ahmed, Ayat AU - Mostafa Mohamed Ahmed A AD - Department of Clinical Pathology and Chemistry, Faculty of Medicine, Minia University, Minia 2422998, Egypt. FAU - Adel Zaky, Hager AU - Adel Zaky H AD - Department of Public Health, Faculty of Medicine, Faculty of Medicine, Minia University, Minia 2422998, Egypt. FAU - Gamil, Aya Nabil AU - Gamil AN AD - Department of Microbiology and Immunology, Minia University, Minia 45638, Egypt. FAU - Arafat Abd Elmoaty, Abd Elmoaty AU - Arafat Abd Elmoaty AE AD - Department of Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Assiut 44654, Egypt. FAU - M Khafagi, Mahmoud AU - M Khafagi M AD - Department of Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Assiut 44654, Egypt. FAU - Mohamed Alkabeer, Ashraf AU - Mohamed Alkabeer A AD - Department of Internal Medicine, Al-Azhar University, Assiut 2422998, Egypt. FAU - Abd Elaziz Alsaid, Aldosoky AU - Abd Elaziz Alsaid A AD - Department of Internal Medicine, Al-Azhar University, Assiut 2422998, Egypt. FAU - A Elhagary, Ahmed AU - A Elhagary A AD - Department of Internal Medicine, Al-Azhar University, Assiut 2422998, Egypt. FAU - Mohammed Aboassy, Walid AU - Mohammed Aboassy W AD - Pediatric Faculty of Medicine Port Said University, Port Said 42526, Egypt. FAU - Nabil Gamil Mohammed, Ahmed AU - Nabil Gamil Mohammed A AD - Department of Pediatric, Faculty of Medicine, Minia University, Minia 2422998, Egypt. LA - eng PT - Journal Article DEP - 20260909 PL - United States TA - World J Clin Pediatr JT - World journal of clinical pediatrics JID - 101627548 PMC - PMC13491160 OTO - NOTNLM OT - Childhood obesity OT - Dyslipidemia OT - Helicobacter pylori OT - Homeostasis model assessment of insulin resistance OT - Insulin resistance OT - Metabolic syndrome phenotype OT - Tumor necrosis factor-alpha COIS- Conflict-of-interest statement: All the authors declare that they have no conflict of interest related to this study. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/09/09 CRDT- 2026/08/21 05:58 PHST- 2026/04/07 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:58 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.5409/wjcp.v15.i3.121926 [doi] PST - epublish SO - World J Clin Pediatr. 2026 Sep 9;15(3):121926. doi: 10.5409/wjcp.v15.i3.121926. eCollection 2026 Sep 9. PMID- 42626192 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260822 IS - 2624-8212 (Electronic) IS - 2624-8212 (Linking) VI - 9 DP - 2026 TI - Digital twin-supported behavioral intention in mothers of young children to prevent childhood obesity: a large language model-based intervention study. PG - 1927993 LID - 10.3389/frai.2026.1927993 [doi] LID - 1927993 AB - INTRODUCTION: Childhood obesity is a major determinant of lifelong non-communicable disease risk, yet early intervention may modify this trajectory. Digital twins and large language models may provide a scalable means of translating individualized risk prediction into understandable and motivating lifestyle guidance. METHODS: We developed a precision-preventive intervention integrating a childhood-overweight digital twin with an empathic, supervised-fine-tuned open-source nutrition-guidance large language model. The model was based on Llama 3-70B and fine-tuned using the Standard Tables of Food Composition in Japan 2020 and its 2023 amendment. Response appropriateness was evaluated using 30 nutrition-related questions independently assessed by three registered dietitians. The digital twin adopted a published Tohoku Medical Megabank Birth and Three-Generation cohort model predicting overweight risk at 36-47 months, 6 years, 11 years, and 14 years. A total of 121 women with a child under 14 years of age participated in the digital-twin visualization and a single chat-based test. RESULTS: The off-the-shelf Llama 3-70B produced a mean of 18 appropriate responses out of 30, whereas the fine-tuned model produced 27 out of 30. The digital-twin visualization and chat consultation were rated highly for clarity, perceived value, behavioral intention, and willingness to continue, with core-item means above 4.9 on a five-point scale. Thematic analysis showed that 112 of 121 participants perceived the recommended lifestyle changes as feasible and achievable gradually. DISCUSSION: The integrated intervention demonstrated preliminary operational feasibility and acceptability. Individualized future-risk visualization combined with supportive conversational guidance was associated with high self-reported behavioral intention. Controlled and longitudinal studies are required to determine whether these preliminary motivational responses translate into sustained behavior change and improved health outcomes. CI - Copyright (c) 2026 Nakamura, Shinoda, Noda, Ishikuro, Obara, Matsubara, Ishii, Onishi and Ohyama. FAU - Nakamura, Kenji AU - Nakamura K AD - Center for Mathematics and Data Science, Gunma University, Maebashi, Gunma, Japan. AD - Innovative Medical Research Center, Gunma University Hospital, Maebashi, Gunma, Japan. FAU - Shinoda, Genki AU - Shinoda G AD - Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Noda, Aoi AU - Noda A AD - Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Ishikuro, Mami AU - Ishikuro M AD - Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Obara, Taku AU - Obara T AD - Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Matsubara, Taeka AU - Matsubara T AD - Interfaculty Initiative in Information Studies, The University of Tokyo, Tokyo, Japan. FAU - Ishii, Hideki AU - Ishii H AD - Department of Cardiovascular Medicine, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan. FAU - Onishi, Masahiro AU - Onishi M AD - System Integration Center, Gunma University Hospital, Maebashi, Gunma, Japan. FAU - Ohyama, Yoshiaki AU - Ohyama Y AD - Innovative Medical Research Center, Gunma University Hospital, Maebashi, Gunma, Japan. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - Front Artif Intell JT - Frontiers in artificial intelligence JID - 101770551 PMC - PMC13491048 OTO - NOTNLM OT - behavioral intention OT - childhood obesity OT - digital twin OT - large language model OT - maternal and child health OT - nutrition counseling OT - precision prevention COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 05:55 PHST- 2026/07/04 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:55 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/frai.2026.1927993 [doi] PST - epublish SO - Front Artif Intell. 2026 Aug 6;9:1927993. doi: 10.3389/frai.2026.1927993. eCollection 2026. PMID- 42625989 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260822 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Patterns of habitual physical activity in children and adolescents with cerebral palsy (GMFCS I-II). PG - 1896196 LID - 10.3389/fspor.2026.1896196 [doi] LID - 1896196 AB - BACKGROUND: To provide tailored recommendations and interventions for physical activity in children with cerebral palsy, it is important to gain insight not only into the amount and intensity, but also into the temporal pattern of activity. This descriptive study describes postures, bouts, transitions, timepoints, frequency, and type of activity in ambulatory children with Cerebral Palsy (CP) and compare these patterns with typically developing (TD) peers. METHODS: Twenty-three children with CP [GMFCS I-II, 11 males, mean age [range] 9 years [7-16]] and 23 TD peers [9 male, mean age[range] 10 years [7-15]] wore two accelerometers for seven consecutive days. A validated human activity recognition model classified following activities; lying, sitting, standing, walking, running, cycling and jumping based on raw acceleration data. RESULTS: Both groups accumulated about five hours of daily physical activity through active postures and locomotion, predominantly through standing ( approximately 200 min) and walking ( approximately 100 min), and short periods of running ( approximately 10 min), cycling (<1 min) and jumping (1-2 min). The accumulated activity was approximately 8% for CP and 10,5% higher for TD on weekdays than weekends. Children with CP were on average approximately 10 to 17 min less active and had approximately 15% less active-sedentary-transitions compared to TD, but without statistical significance. During weekdays, all children engaged in standing bouts of up to 10 min, walking bouts of up to two minutes and running bouts of up to 24 s. During weekends, the proportion of children performing different bout lengths decreased as bout length increased. CONCLUSION: Ambulatory children with CP, predominantly classified as GMFCS I, demonstrated habitual physical activity patterns, with no statistically significant difference from TD peers. Additionally, there was no statistically significant difference between weekdays and weekends for either group. Substantial within-group variation highlights the heterogeneity of habitual physical activity patterns in children. Furthermore, given small sample size and low statistical power, these findings should be regarded as descriptive and hypothesis-generating. CI - (c) 2026 Torring, Roeleveld, Lydersen, Bardal and Braendvik. FAU - Torring, Marte Fossflaten AU - Torring MF AD - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. AD - Physiotherapy Unit, Trondheim Municipal, Trondheim, Norway. FAU - Roeleveld, Karin AU - Roeleveld K AD - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. FAU - Lydersen, Stian AU - Lydersen S AD - Regional Centre for Child and Youth - Mental Health and Child Welfare, Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. FAU - Bardal, Ellen Marie AU - Bardal EM AD - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. AD - Clinic of Rehabilitation, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. FAU - Braendvik, Siri Merete AU - Braendvik SM AD - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. AD - Clinic of Rehabilitation, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. LA - eng PT - Journal Article DEP - 20260731 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13491053 OTO - NOTNLM OT - activity patterns OT - activity types OT - cerebral palsy OT - habitual physical activity OT - human activity recognition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/07/31 CRDT- 2026/08/21 05:42 PHST- 2026/05/31 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:42 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.3389/fspor.2026.1896196 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jul 31;8:1896196. doi: 10.3389/fspor.2026.1896196. eCollection 2026. PMID- 42625860 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260822 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - A simulation-based framework for tracking decision-making development in youth basketball: operationalising Vygotsky's zone of proximal development through Bayesian multilevel modelling and verbal protocol analysis. PG - 1872966 LID - 10.3389/fspor.2026.1872966 [doi] LID - 1872966 AB - INTRODUCTION: Sports coaching research remains polarised between direct instruction approaches emphasising feedback and repetition vs. constraints-led approaches favouring athlete discovery through task design. This debate persists partly because existing methods cannot distinguish whether athletes are genuinely internalising tactical understanding or merely following external instructions. We present a methodological simulation study proposing a framework that operationalises Cultural-Historical Activity Theory-particularly Vygotsky's Zone of Proximal Development (ZPD)-through Bayesian multilevel modelling and verbal protocol analysis to track the transition from coach-dependent to self-directed tactical thinking in youth athletes. No human participants were involved, as this study uses exclusively simulated data. METHODS: We outline a research protocol integrating: (1) a four-phase longitudinal design (baseline --> scaffolded coaching --> independent test --> transfer challenge), (2) verbal protocol instruments assessing spatial awareness, decision-making reasoning, and metacognitive reflection, (3) linguistic coding distinguishing other-regulation from self-regulation, and (4) Bayesian multilevel models capturing individual developmental heterogeneity. Using simulated data ( n = 80 athletes, 25 sessions), we demonstrate-not empirically test-that the framework's statistical model recovers theoretically-predicted developmental patterns embedded in the data-generating process. We additionally simulate a "compliance" data-generating process, in which scaffolding gains do not persist after withdrawal, to test whether the framework can discriminate internalisation from mere compliance. RESULTS: The simulation confirms that, under specified assumptions, the framework successfully recovers embedded theoretical patterns: accelerated growth during scaffolding, maintained gains after withdrawal, successful transfer, differential ZPD width effects, and progression from external to internal regulation. We report this recovery result from a single simulated draw, and separately report whether the same modelling pipeline can discriminate this internalisation pattern from a simulated "compliance" alternative in which scaffolding gains do not persist. A full simulation-based calibration exercise across many replications would strengthen the recovery claim further but is disproportionate to a methodological proof-of-concept and is left for future methodological work. DISCUSSION: We provide researchers with a complete methodological package-study design templates, scoring rubrics, coding schemes, statistical specifications, and reproducible code-enabling rigorous empirical tests of Activity Theory in sport. This proof-of-concept bridges Vygotskian theory with computational methods and establishes that the proposed framework has adequate sensitivity to detect theoretically-predicted patterns when they are present in real data. CI - (c) 2026 Carvalho, Miguel and Goncalves. FAU - Carvalho, Humberto M AU - Carvalho HM AD - Department of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - School of Sports, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. AD - Post-graduate Programme in Psychology, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. FAU - Miguel, Caio G AU - Miguel CG AD - School of Sports, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. FAU - Goncalves, Carlos E AU - Goncalves CE AD - Faculty of Sport Sciences and Physical Education, University of Coimbra, Coimbra, Portugal. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13490169 OTO - NOTNLM OT - Vygotsky OT - activity theory OT - basketball OT - coaching pedagogy OT - tactical learning OT - verbal protocols OT - youth development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors HC, CG declared that they were an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 05:31 PHST- 2026/05/05 00:00 [received] PHST- 2026/07/20 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:31 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fspor.2026.1872966 [doi] PST - epublish SO - Front Sports Act Living. 2026 Aug 6;8:1872966. doi: 10.3389/fspor.2026.1872966. eCollection 2026. PMID- 42625773 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260822 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - A descriptive cross-sectional study on the dry eye disease in children in Xiamen, China. PG - 1897928 LID - 10.3389/fmed.2026.1897928 [doi] LID - 1897928 AB - OBJECTIVE: To evaluate the clinical characteristics, risk factors, and applicability of three commonly used dry eye disease (DED) questionnaires (OSDI, CDEQ, and COCI) in children and adolescents in Xiamen, China, aiming to provide preliminary descriptive data in DED pediatric population. METHODS: This single-center cross-sectional study included 105 pediatric patients with DED. Demographic data, clinical findings, risk factors, and questionnaire scores were collected. Univariate analysis was used to identify associated factors. Internal consistency was assessed using Cronbach's alpha, inter-questionnaire correlations using Spearman analysis, and discriminative validity using Kruskal-Wallis and Mann-Whitney U tests. RESULTS: Among 105 participants (mean age 7.86 +/- 3.13 years; 64.76% male), the majority were elementary school-aged (54.29%). All patients exhibited meibomian gland dysfunction, and 92.38% had mixed-type DED. Age (p = 0.012), BMI (p = 0.067), outdoor activity (p = 0.029), and sleep duration (p = 0.055) were associated with DED subtype or severity. The response rates of the CDEQ and COCI were 100%. All questionnaires showed acceptable internal consistency (Cronbach's alpha = 0.642-0.919) and moderate correlations. However, none demonstrated significant discriminative ability for DED severity (p > 0.05). CONCLUSION: Given the cross-sectional design, no causal inference can be drawn from these findings. Within this descriptive framework, mixed-type DED with predominant MGD emerged as the main subtype in children in Xiamen. Obesity, limited outdoor activity, and short sleep duration were identified as potential correlates. The CDEQ and COCI showed acceptable feasibility and reliability, while the OSDI demonstrated limited applicability. None of the three questionnaires effectively distinguished severity, underscoring the need for pediatric-specific tools. CI - Copyright (c) 2026 Fang, Sun, Xiong, Yin, Yang and Bu. FAU - Fang, Weifang AU - Fang W AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Sun, Le AU - Sun L AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China. FAU - Xiong, Weiwei AU - Xiong W AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Yin, Xue AU - Yin X AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Yang, Hui AU - Yang H AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Bu, Jinghua AU - Bu J AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13490148 OTO - NOTNLM OT - CDEQ OT - COCI OT - OSDI OT - dry eye disease OT - pediatric dry eye disease OT - questionnaire COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 05:21 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:21 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fmed.2026.1897928 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Aug 6;13:1897928. doi: 10.3389/fmed.2026.1897928. eCollection 2026. PMID- 42625738 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260822 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Age-specific association between dietary nutrient adequacy and self-rated health in Korean adolescents: a cross-sectional study based on the Korea National Health and Nutrition Examination Survey 2022-2024. PG - 1880706 LID - 10.3389/fnut.2026.1880706 [doi] LID - 1880706 AB - BACKGROUND: Self-rated health (SRH) reliably predicts mortality and chronic disease risk, yet the association between the mean adequacy ratio (MAR), a nutrient adequacy index, and SRH in Korean adolescents remains underexplored. METHODS: This cross-sectional study analyzed 1,053 adolescents aged 12-18 years from Korea National Health and Nutrition Examination Survey (KNHANES) 2022-2024, excluding those with extreme energy intakes for their sex and age group. MAR was calculated as the mean of nine nutrient adequacy ratios, each capped at 1.0 using the 2020 Korean Dietary Reference Intakes (KDRI). The dietary diversity score (DDS) was calculated from five food groups. SRH was dichotomized as good (1-2) or fair-to-poor (3-5), and associations were estimated using complex-sample logistic regression with a quasibinomial family. RESULTS: In the fully adjusted model, higher MAR was associated with lower odds of fair-to-poor SRH (OR: 0.88, 95% CI: 0.78-0.99; p = 0.040). In exploratory analyses, this association was observed in adolescents aged 15-18 years (OR: 0.79, 95% CI: 0.68-0.93; p = 0.005) but not 12-14 years (OR: 1.02, 95% CI: 0.85-1.22; p = 0.851; age group interaction p = 0.017). DDS showed no association with fair-to-poor SRH (OR: 1.00, 95% CI: 0.83-1.21; p = 0.960). MAR was not associated with overweight (OR: 1.06, 95% CI: 0.91-1.23; p = 0.477) or abdominal obesity (OR: 1.03, 95% CI: 0.88-1.20; p = 0.737). A sensitivity analysis using the 2025 KDRI yielded consistent results: the primary association remained significant (OR: 0.87, 95% CI: 0.78-0.98; p = 0.027), and the age group interaction remained statistically significant (p = 0.013). CONCLUSION: Higher MAR was associated with lower odds of fair-to-poor SRH in Korean adolescents, particularly among those aged 15-18 years. Longitudinal studies are needed to confirm these findings and support nutrition programs targeting older Korean adolescents. CI - Copyright (c) 2026 Woo. FAU - Woo, Dongyoun AU - Woo D AD - Independent Researcher, Daejeon, Republic of Korea. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13489852 OTO - NOTNLM OT - KNHANES OT - Korean adolescents OT - age-specific association OT - cross-sectional study OT - dietary diversity score OT - mean adequacy ratio OT - nutrient adequacy OT - self-rated health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 05:14 PHST- 2026/05/13 00:00 [received] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:14 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fnut.2026.1880706 [doi] PST - epublish SO - Front Nutr. 2026 Aug 6;13:1880706. doi: 10.3389/fnut.2026.1880706. eCollection 2026. PMID- 42625712 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260822 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - External genital features and normative values for anogenital distances and penile length at birth in a healthy Italian population: data from the LIFE-MILCH project. PG - 1838976 LID - 10.3389/fendo.2026.1838976 [doi] LID - 1838976 AB - INTRODUCTION: Anogenital distance (AGD) and penile length (PL) are considered as surrogate biomarkers of fetal androgen action and are used to study the impact of prenatal exposure to endocrine disrupting chemicals. Data for newborn sex-specific references of both AGD and PL are currently scarce for the Italian population. This study aimed to provide normative data in a large group of Italian newborns and to assess any associations with anthropometric parameters. METHODS: Data were collected at birth in mother-infant dyads from April 2021 to September 2022. Four hundred and sixty-two/675 neonates at term of uncomplicated pregnancies were enrolled from three different Italian Hospitals. Newborns were divided in 5 subgroups according to weeks of gestational age(GA):1(37-37 + 6d w),2(38-38 + 6d w),3(39-39 + 6d w),4(40- 40 + 6d w),5(> 41w) and in 4 sub-groups according to birth weight (BW): A(2501-3000 g), B(3001-3500 g), C(3501-4000 g), D (>4001 g). Trained staff measured AGD and PL in newborns with an analogical caliper using the TIDES method. Anogenital distances (AGDs) considered were: ano-scrotal (AGD(AS)) and ano-penile (AGD(AP)) in males, ano-fourchette (AGD(AF)) and ano-clitoral (AGD(AC))in females. Correlations among AGDs and anthropometric measures were evaluated by Pearson correlation analysis. P<0.05 was significant. Data were expressed as mean+/- standard deviation. RESULTS: Overall, in males AGDs were longer than in females. Considering the 5 subgroups for GA, AGD(AP) was significantly longer than AGD(AC) in neonates born at and after 40 weeks(p<0.05) whereas AGD(AS) was significantly longer than AGD(AF) in neonates born at and after 39 weeks(p<0.05). AGD(AS) increased with increasing GA. Considering AGDs according to BW, AGD(AP) was significantly longer than AGD(AC) in newborns with a BW between 3001 and 4000 g(p<0.05), whereas AGD(AS) was significantly longer than AGD(AF) in newborns with a BW between 2501 g and 4000 g(p<0.05). Mean PL of male newborns (N = 208) was 24.4 +/- 6.83 mm and increased with GA. In the correlation analysis a positive significant correlation was found between AGD(AS) and PL (r=0.576, p<0.001). CONCLUSION: This study provided measurements and reference values for AGD and PL, based also on GA and BW, in a large group of newborns, supplying a valid well-reproducible instrument for clinical practice and the basis for further studies. CI - Copyright (c) 2026 Righi, Pelosi, Alberghi, Fontana, Davolio, Rotteglia, Sartori, Brambilla, Petrolini, Perrone, Shulhai, Dessi, Petza, Pintus, De Fanti, Gargano, Papini, Fanos, Palanza and Street. FAU - Righi, Beatrice AU - Righi B AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Pelosi, Annalisa AU - Pelosi A AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Alberghi, Francesca AU - Alberghi F AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Fontana, Marta AU - Fontana M AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Davolio, Emanuela AU - Davolio E AD - Unit of Obstetrics and Gynecology, Azienda Unita Sanitaria Locale (USL)-IRCCS of Reggio Emilia, Reggio Emilia, Italy. FAU - Rotteglia, Cecilia AU - Rotteglia C AD - Unit of Obstetrics and Gynecology, Azienda Unita Sanitaria Locale (USL)-IRCCS of Reggio Emilia, Reggio Emilia, Italy. FAU - Sartori, Chiara AU - Sartori C AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Brambilla, M Maddalena AU - Brambilla MM AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. AD - Neonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children's Hospital, Parma, Italy. FAU - Petrolini, Chiara AU - Petrolini C AD - Neonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children's Hospital, Parma, Italy. FAU - Perrone, Serafina AU - Perrone S AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. AD - Neonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children's Hospital, Parma, Italy. FAU - Shulhai, Anna-Mariia AU - Shulhai AM AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Dessi, Angelica AU - Dessi A AD - Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Azienda Ospedaliero Universitaria (AOU) Cagliari, Cagliari, Italy. FAU - Petza, Silvia AU - Petza S AD - Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Azienda Ospedaliero Universitaria (AOU) Cagliari, Cagliari, Italy. FAU - Pintus, Roberta AU - Pintus R AD - Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Azienda Ospedaliero Universitaria (AOU) Cagliari, Cagliari, Italy. FAU - De Fanti, Alessandro AU - De Fanti A AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Gargano, Giancarlo AU - Gargano G AD - Department of Mother and Child, Neonatal Intensive Care Unit, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Papini, Anna Maria AU - Papini AM AD - Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Italy. FAU - Fanos, Vassilios AU - Fanos V AD - Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Azienda Ospedaliero Universitaria (AOU) Cagliari, Cagliari, Italy. AD - Department of Medicine and Surgery, University of Cagliari, Cagliari, Italy. FAU - Palanza, Paola AU - Palanza P AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Street, Maria Elisabeth AU - Street ME AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. AD - Unit of Paediatrics, University Hospital of Parma, Parma, Italy. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Male MH - Infant, Newborn MH - Female MH - *Penis/anatomy & histology MH - Italy/epidemiology MH - *Anal Canal/anatomy & histology MH - Reference Values MH - Birth Weight MH - Gestational Age MH - Pregnancy MH - Adult PMC - PMC13489917 OTO - NOTNLM OT - anogenital distance OT - newborn OT - normative values OT - penile length OT - references COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors PP, AMP, MES declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 05:12 PHST- 2026/03/25 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:12 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fendo.2026.1838976 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 6;17:1838976. doi: 10.3389/fendo.2026.1838976. eCollection 2026. PMID- 42625158 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260909 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Aug 20 TI - Addressing insufficient physical activity in children with obesity in a 4-month physical activity on prescription intervention: a single-group pre-post study. LID - 10.1186/s12889-026-29071-9 [doi] LID - 2407 AB - BACKGROUND: Childhood obesity is a complex disease and a growing global public health challenge. Physical activity on prescription (PAP) is an evidence-based method to increase physical activity (PA) in adults but has been sparsely studied in children with obesity. The aim of the study was to explore changes in PA patterns in 6-12-year-old children with obesity after a 4-month PAP intervention and to explore age- and sex-related differences. METHODS: The cohort consisted of 42 children (20 boys), 6-12 years old, treated at paediatric or rehabilitation clinics in Gothenburg and surrounding municipalities, Sweden. An individualised PAP intervention was provided, comprising individual counselling, a written prescription with an individually tailored PA recommendation, and structured follow-up. Main activities performed by the children were ball sports, swimming and walking, the latter including daily walks to and from school. Physical activity was measured using accelerometers attached to the participants' hips for 7 days before and after the intervention. Changes pre- to post-intervention in PA patterns were analysed using Wilcoxon's signed rank test. RESULTS: Of the 42 included children, 35 completed the intervention (dropout rate 16.7%), of whom 32 provided valid accelerometer data. The sample was balanced by sex (16 girls/16 boys) and age (n = 16 in each subgroup). No significant changes were observed in PA patterns in the overall group or in subgroup analyses by sex and age. Overall satisfaction with the PAP treatment was high among both children and parents. CONCLUSIONS: Although no significant changes in PA patterns were observed post-intervention, children and parents expressed satisfaction with the PAP intervention. The lack of significant findings may partly be explained by the small sample size and limited statistical power, the extent and duration of the intervention, and the limited ability of accelerometers to capture certain types of activities. Further research is needed to explore the feasibility, adherence, and long-term effects of PAP interventions in children with obesity, with implications for broader public health efforts. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04847271, registered 14 April 2021. CI - (c) 2026. The Author(s). FAU - Tornqvist, Jessica AU - Tornqvist J AUID- ORCID: 0009-0007-3775-7364 AD - Centre for Physical Activity, Region Vastra Gotaland, Gothenburg, Sweden. AD - Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Lauruschkus, Katarina AU - Lauruschkus K AUID- ORCID: 0000-0002-1801-8503 AD - Faculty of Medicine, Department of Health Sciences, Lund University, Lund, Sweden. AD - Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden. FAU - Bernhardsson, Susanne AU - Bernhardsson S AUID- ORCID: 0000-0001-8212-7678 AD - Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Research, Education, Development and Innovation, Primary Health Care, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Melin, Karin AU - Melin K AUID- ORCID: 0000-0002-3297-7735 AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Paediatric Neurology and Psychiatry, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Karlsson, Li AU - Karlsson L AUID- ORCID: 0009-0000-7660-0828 AD - Centre for Physical Activity, Region Vastra Gotaland, Gothenburg, Sweden. AD - Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Arvidsson, Daniel AU - Arvidsson D AUID- ORCID: 0000-0002-3112-5434 AD - Centre for Health and Performance, Department of Food and Nutrition, and Sport Science, University of Gothenburg, Gothenburg, Sweden. FAU - Fridolfsson, Jonatan AU - Fridolfsson J AUID- ORCID: 0000-0002-7003-4025 AD - Center for Lifestyle Intervention, Department of Molecular and Acute Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of MGAO, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Greven, Christian AU - Greven C AUID- ORCID: 0009-0009-4745-1582 AD - Centre for Health and Performance, Department of Food and Nutrition, and Sport Science, University of Gothenburg, Gothenburg, Sweden. AD - Department of MGAO, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Lundqvist, Stefan AU - Lundqvist S AUID- ORCID: 0000-0002-3467-8499 AD - Centre for Physical Activity, Region Vastra Gotaland, Gothenburg, Sweden. stefan.lundqvist@gu.se. AD - Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. stefan.lundqvist@gu.se. AD - Research, Education, Development and Innovation, Primary Health Care, Region Vastra Gotaland, Gothenburg, Sweden. stefan.lundqvist@gu.se. LA - eng SI - ClinicalTrials.gov/NCT04847271 PT - Clinical Trial PT - Journal Article DEP - 20260820 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - Accelerometry MH - *Exercise MH - *Health Promotion/methods MH - *Pediatric Obesity/therapy MH - Sweden PMC - PMC13495397 OTO - NOTNLM OT - Accelerometry OT - Paediatric obesity OT - Physical Activity on Prescription OT - Physical activity OT - Sedentary behaviour COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the ethical principles described in the Declaration of Helsinki and was approved by the Swedish Ethical Review Authority (reference no 2021-03632, 2021-06810-02). Written and verbal informed consent were collected from participating parents and verbal assent from the children. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/21 05:35 MHDA- 2026/08/21 05:36 PMCR- 2026/08/20 CRDT- 2026/08/21 00:20 PHST- 2026/01/22 00:00 [received] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/08/21 05:36 [medline] PHST- 2026/08/21 05:35 [pubmed] PHST- 2026/08/21 00:20 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - 10.1186/s12889-026-29071-9 [pii] AID - 29071 [pii] AID - 10.1186/s12889-026-29071-9 [doi] PST - epublish SO - BMC Public Health. 2026 Aug 20;26(1):2407. doi: 10.1186/s12889-026-29071-9. PMID- 42625002 OWN - NLM STAT- Publisher LR - 20260821 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) DP - 2026 Aug 20 TI - Can weight status in the first year of life predict well-being in the first years of school? LID - 10.1038/s41366-026-02180-6 [doi] AB - BACKGROUND: Early life represents a critical period for shaping long-term health outcomes, with early interventions playing a significant role in promoting well-being. This study aimed to investigate whether infant weight status could predict concerns of development and well-being in the first years of school using health nurse data. METHODS: Data from the Danish Child Health Database collaboration included 54 917 children and families who received home visits at 8-10 months and school examinations by health nurses during the children's first years of school. Weight status was measured using BMI z-scores and tested categorical, linear and using restricted cubic splines to explore predictive performance. Well-being was assessed by health nurses using seven indicators, including language skills, motor development, emotional well-being, and peer relationship problems. Model performance was evaluated through visualization of restricted cubic splines and by Area Under the Curve (AUC). RESULTS: Infant weight status at 8-10 months showed poor predictive performance (AUC < = 0.533) across all indicators of well-being in the first years of school. While certain weight categories-especially severe thinness, overweight, and obesity-were linked to specific concerns such as language skills and motor development, these associations had wide confidence intervals. CONCLUSION: Although infant weight status may indicate later health concerns, it was not a reliable predictor of health nurses' well-being concerns in the early school years. The findings demonstrated that predictive performance remained poor across several models, suggesting that infant weight alone may not capture the complexity of factors influencing later well-being as recorded by health nurses. CI - (c) 2026. The Author(s). FAU - Liljendahl, Mie Sylow AU - Liljendahl MS AUID- ORCID: 0000-0001-7419-7086 AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. lilj@sdu.dk. FAU - Rasmussen, Mette AU - Rasmussen M AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Pant, Sofie Weber AU - Pant SW AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Pommerencke, Lis Marie AU - Pommerencke LM AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Thygesen, Lau Caspar AU - Thygesen LC AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Pedersen, Trine Pagh AU - Pedersen TP AUID- ORCID: 0000-0003-4622-6534 AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. LA - eng PT - Journal Article DEP - 20260820 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM COIS- Competing interests: The authors declare no competing interests. Ethical approval: Data collection was conducted in accordance with national regulations on data protection and informed consent. Approval for the transfer of data from the participating municipalities to the National Institute of Public Health was granted by the Team for Medical Records Research in the Capital Region of Denmark (R-22030405), and data transfer agreements have been established with all participating municipalities. The data collection is registered with the Research & Innovation Organization at the University of Southern Denmark (project number: 11667). EDAT- 2026/08/21 05:35 MHDA- 2026/08/21 05:35 CRDT- 2026/08/21 00:11 PHST- 2025/07/23 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/06/26 00:00 [revised] PHST- 2026/08/21 05:35 [medline] PHST- 2026/08/21 05:35 [pubmed] PHST- 2026/08/21 00:11 [entrez] AID - 10.1038/s41366-026-02180-6 [pii] AID - 10.1038/s41366-026-02180-6 [doi] PST - aheadofprint SO - Int J Obes (Lond). 2026 Aug 20. doi: 10.1038/s41366-026-02180-6. PMID- 42624607 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260827 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 8 DP - 2026 Aug 19 TI - Reassessing mid-upper arm circumference thresholds for predicting nutritional status and pregnancy outcomes among pregnant adolescents in Bundibugyo District, Uganda: protocol for a health facility-based prospective cohort study. PG - e121400 LID - 10.1136/bmjopen-2026-121400 [doi] LID - e121400 AB - INTRODUCTION: In 2023, Sub-Saharan Africa recorded the world's highest teenage pregnancy rate of 4.4 per 1000 women compared with the global average of 1.5 per 1000, highlighting the need for accurate nutritional assessment during pregnancy. Current mid-upper arm circumference (MUAC) thresholds differ between non-pregnant adolescents (18.5 cm) and pregnant adolescents (23 cm) as per the Uganda Integrated Management of Acute Malnutrition guidelines. This classification can lead to inadequate treatment and mislabelling of adolescents as non-responders, despite nutritional improvements. This study will reassess MUAC thresholds for predicting nutritional status and pregnancy outcomes among pregnant adolescents in Bundibugyo District, Uganda. METHODS AND ANALYSIS: This health facility-based prospective cohort study will target 241 pregnant women comprising 121 pregnant adolescents (10-19 years) and 120 adults (20-49 years) in their first trimester (/= 5.6 mmol/L were randomly selected from 210 participants, alongside 60 matched healthy controls (FPG < 5.6 mmol/L). Semiquantitative lipidomics was performed, and lipid ratios were calculated from identified characteristic lipids. Univariate and multiple regression analyses were conducted. RESULTS: After adjusting for age, sex, body mass index (BMI), early-life risk factors, and metabolic disorder factors, six lipid species remained independently associated with FPG variations (Bonferroni-adjusted p < 0.05). Lipid ratios derived from these six lipids differed significantly between groups; the decreased levels of phosphatidylethanolamine/diacyl-phosphatidylcholine was significantly correlated with elevated FPG, whereas elevated levels of ether-phosphoatidylcholine/diacyl-phosphoatidylcholine ratios was significantly associated with elevated FPG. Three phosphatidylcholine species showed good diagnostic performance (AUC = 0.811, 95% CI: 0.733-0.881). Their composite signature outperformed both the baseline model (age, sex; AUC: 0.882 vs. 0.584, DeLong's p < 0.001), and the extended risk factor model (age, sex, BMI, and early-life riskr factors, AUC: 0.882 vs. 0.635, DeLong's p < 0.001). The robustness of the three PCs was further supported by sensitivity analyses, which demonstrated consistent performance using Firth penalized regression (AUC = 0.883) and an alternative FPG cutoff at the 75th percentile (AUC = 0.834). CONCLUSIONS: In this cross-sectional targeted lipidomics study, a three PC lipid panel was independently associated with subclinical hyperglycemia in preschool-aged children and showed robust diagnostic performance. Two lipid ratios were also associated with FPG. These findings identify a potential lipid panel for early risk detection in this understudied population, pending validation in larger cohorts. CI - Copyright (c) 2026 Zhang, Wang, Lv, Huang, Guo, Jiang, Zhang, Liu and Chen. FAU - Zhang, Haifeng AU - Zhang H AD - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Wang, Jing AU - Wang J AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Lv, Yueguang AU - Lv Y AD - Key Laboratory of Consumer Product Quality Safety Inspection and Risk Assessment, State Administration for Market Regulation, Beijing, China. FAU - Huang, Yiying AU - Huang Y AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Guo, Yuanyuan AU - Guo Y AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Jiang, Chang AU - Jiang C AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Zhang, Ting AU - Zhang T AD - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Liu, Gongshu AU - Liu G AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Chen, Fangfang AU - Chen F AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article DEP - 20260805 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Phosphatidylcholines) RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Hyperglycemia/diagnosis/blood MH - Male MH - Pilot Projects MH - Cross-Sectional Studies MH - Child, Preschool MH - *Phosphatidylcholines/blood MH - Blood Glucose/analysis/metabolism MH - *Biomarkers/blood MH - Lipidomics PMC - PMC13485523 OTO - NOTNLM OT - diagnostic signature OT - glycerophopholipids OT - lipid ratio OT - lipidomics OT - pediatric hyperglycemia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/20 11:41 MHDA- 2026/08/20 11:42 PMCR- 2026/08/05 CRDT- 2026/08/20 07:32 PHST- 2026/05/11 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/20 11:42 [medline] PHST- 2026/08/20 11:41 [pubmed] PHST- 2026/08/20 07:32 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - 10.3389/fendo.2026.1878086 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 5;17:1878086. doi: 10.3389/fendo.2026.1878086. eCollection 2026. PMID- 42620310 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260820 LR - 20260821 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Effect of a theory-based coach education program on the objectively assessed motivational climate in grassroots football across four European countries: results from the Promoting Adolescent Physical Activity (PAPA) project. PG - 1563931 LID - 10.3389/fpsyg.2026.1563931 [doi] LID - 1563931 AB - INTRODUCTION: This study examined the longitudinal effects of the Empowering Coaching program, designed to promote more adaptive motivational climates as created by coaches in grassroots youth football across different countries. METHODS: Sixty-eight coaches from four countries (England, France, Spain, and Greece) were randomly assigned to either the intervention or control group. Coaches' behaviors were assessed at three time points during the season using a validated observational system based on motivational theories. RESULTS: A series of linear and quadratic multilevel models revealed that, compared to the control group, intervention coaches demonstrated a significant reduction in disempowering behaviors (i.e., ego-involving climate) across the season and a temporary increase (assessed 1 month post-intervention) in features of an empowering climate (i.e., autonomy support and relatedness support). CONCLUSION: Findings highlight the training program's short- and long-term impacts and point to the need for continued support to sustain positive coaching practices and reduce the occurrence of negative coaching behaviors. CI - Copyright (c) 2026 Tzioumakis, Tessier, Smith, Fabra Lopez, Krommidas, Comoutos, Keramidas, Appleton, Sarrazin, Balaguer, Digelidis, Quested, Papaioannou and Duda. FAU - Tzioumakis, Yannis S AU - Tzioumakis YS AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Tessier, Damien AU - Tessier D AD - SENS, Universite Grenoble Alpes, Grenoble, France. FAU - Smith, Nathan AU - Smith N AD - University of Coventry, Coventry, United Kingdom. FAU - Fabra Lopez, Priscila AU - Fabra Lopez P AD - Department of Psychology, Universidad Europea de Valencia, Valencia, Spain. FAU - Krommidas, Charalambos AU - Krommidas C AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Comoutos, Nikos AU - Comoutos N AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Keramidas, Panagiotis AU - Keramidas P AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Appleton, Paul R AU - Appleton PR AD - School of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, United Kingdom. AD - Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom. FAU - Sarrazin, Philippe AU - Sarrazin P AD - SENS, Universite Grenoble Alpes, Grenoble, France. FAU - Balaguer, Isabel AU - Balaguer I AD - Department of Social Psychology, Faculty of Psychology and Speech Therapy, University of Valencia, Valencia, Spain. FAU - Digelidis, Nikos AU - Digelidis N AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Quested, Eleanor AU - Quested E AD - Curtin University, Perth, WA, Australia. FAU - Papaioannou, Athanasios G AU - Papaioannou AG AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Duda, Joan L AU - Duda JL AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom. LA - eng PT - Journal Article DEP - 20260805 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13485734 OTO - NOTNLM OT - Achievement Goal Theory OT - coach training OT - empowering coaching OT - motivational climate OT - observation OT - self-determination theory OT - youth football COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/20 11:41 MHDA- 2026/08/20 11:42 PMCR- 2026/08/05 CRDT- 2026/08/20 06:34 PHST- 2025/01/20 00:00 [received] PHST- 2026/01/14 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/08/20 11:42 [medline] PHST- 2026/08/20 11:41 [pubmed] PHST- 2026/08/20 06:34 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1563931 [doi] PST - epublish SO - Front Psychol. 2026 Aug 5;17:1563931. doi: 10.3389/fpsyg.2026.1563931. eCollection 2026. PMID- 42619597 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260822 IS - 1460-2210 (Electronic) IS - 0141-5387 (Print) IS - 0141-5387 (Linking) VI - 48 IP - 5 DP - 2026 Aug 6 TI - Frontal sinus morphology and maturation determination. LID - 10.1093/ejo/cjag059 [doi] LID - cjag059 AB - AIM: To determine the relationship between frontal sinus morphometric measurements and established maturation indicators obtained from hand-wrist and lateral cephalometric radiographs, and to evaluate the diagnostic performance of frontal sinus morphometric measurements in discriminating growth and developmental stages. MATERIALS AND METHODS: This retrospective study analysed radiographs of 240 patients aged 9-19 years who underwent simultaneous hand-wrist and cephalometric imaging. Patients were categorized into six cervical vertebral maturation stages (CVS), with 20 females and 20 males in each stage. Hand-wrist (HWS), cervical vertebra (CVS), and dental maturation (DS) stages were assessed. Frontal sinus measurements included maximum height (FSHeight), maximum width (FSWidth), frontal sinus index (FSIndex), area (FSArea), and perimeter (FSPerimeter). Spearman's Rho assessed correlations, and ROC analysis evaluated diagnostic performance with cut-off-based accuracy rates. Reliability was examined using the Kappa coefficient, Kendall's tau-b, and intraclass correlation coefficient (ICC). RESULTS: After Benjamini-Hochberg false discovery rate (FDR) correction, no significant correlations were found between HWS or DS stages and FSHeight in male patients, or between CVS or DS stages and FSIndex. In females, FSArea showed the highest discriminatory performance for classifying the transition from pre-pubertal to pubertal stage (AUC = 0.794; P < 0.001). In males, FSWidth showed the strongest discriminatory performance (AUC = 0.817; P < 0.001). For the transition from the pubertal to post-pubertal stage, FSWidth showed the highest discriminatory performance (AUC = 0.846; P < 0.001), and all frontal sinus measurements were statistically significant in both sexes. CONCLUSION: Frontal sinus morphometry showed high reliability and meaningful associations with age and maturation indicators. However, as AUC values ranged from moderate to good (0.655-0.846) and diagnostic performance varied by sex, maturation system, and transition stage, frontal sinus morphometry should be regarded as a supplementary rather than a standalone or definitive indicator of skeletal maturation, pending longitudinal validation. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Orthodontic Society. FAU - Kok, Hatice AU - Kok H AUID- ORCID: 0000-0002-5874-9474 AD - Faculty of Dentistry, Department of Orthodontics, Selcuk University, Alaeddin Keykubat Campus, Akademi Square, Yeni Istanbul Street No. 309, 42150 Selcuklu, Konya, Turkiye. LA - eng PT - Journal Article PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 SB - IM MH - Humans MH - Child MH - Cephalometry/methods MH - Female MH - Retrospective Studies MH - Male MH - Adolescent MH - *Age Determination by Skeleton/methods MH - Cervical Vertebrae/growth & development/diagnostic imaging MH - *Frontal Sinus/diagnostic imaging/growth & development/anatomy & histology MH - Young Adult MH - ROC Curve MH - Reproducibility of Results MH - Wrist/diagnostic imaging MH - Sex Factors PMC - PMC13490868 OTO - NOTNLM OT - ROC curve OT - frontal sinus OT - growth and development OT - maturity OT - orthodontics COIS- Conflicts of interest: The author declares that there is no conflict of interest. EDAT- 2026/08/20 11:41 MHDA- 2026/08/20 11:42 PMCR- 2026/08/20 CRDT- 2026/08/20 05:03 PHST- 2026/08/20 11:42 [medline] PHST- 2026/08/20 11:41 [pubmed] PHST- 2026/08/20 05:03 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - 8766858 [pii] AID - cjag059 [pii] AID - 10.1093/ejo/cjag059 [doi] PST - ppublish SO - Eur J Orthod. 2026 Aug 6;48(5):cjag059. doi: 10.1093/ejo/cjag059. PMID- 42618949 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260820 LR - 20260822 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Aug 6 TI - A descriptive study of patients' and families' experience of multifamily therapy for eating disorders in young adults. LID - 10.1186/s40337-026-01730-7 [doi] LID - 193 AB - BACKGROUND: Eating disorders (EDs) have profound consequences not only for affected individuals but also for their families. While multifamily therapy (MFT) is well established for children and adolescents with an ED, less is known about its relevance and impact for young adults and their families. This study aimed to explore and describe experiences and outcomes of a MFT programme for young adults with a severe ED, and their family members. METHODS: A descriptive multi-method design was used, combining qualitative and quantitative data collected at a regional specialist centre in Norway. Qualitative data consisted of group and individual interviews with young women with an ED, and family members who had participated in MFT between 2012 and 2022. Reflexive thematic analysis was applied. Quantitative data were collected from 47 young adult women and 99 family members before and after the MFT programme, using validated measures of ED psychopathology, mental health, quality of life, and family functioning. Descriptive and pre-post analyses were conducted. RESULTS: Qualitative findings generated two overarching themes: "Knowledge and tools for understanding" and "Understand and be understood". Participants described MFT as providing experiential learning, shared language, and concrete metaphors that enhanced insight into the illness and improved family communication. Quantitatively, patients reported reduced body shape concern, hostility, and trait anxiety, as well as increased satisfaction with their environment. Family members reported significantly reduced perceived burden, guilt, and need for accommodation, alongside lower levels of state anxiety following MFT. CONCLUSIONS: Findings suggest that MFT may offer meaningful benefits for both young adults with an ED and their families by strengthening understanding, communication, and emotional coping. The study extends existing evidence by highlighting the relevance of MFT beyond adolescence and underscores the importance of family-oriented interventions for young adults with a severe ED. CI - (c) 2026. The Author(s). FAU - Brinchmann, Berit Store AU - Brinchmann BS AUID- ORCID: 0000-0001-6541-4931 AD - Regional Centre for Eating Disorders, Nordland Hospital Trust, Bodo, Norway. berit.s.brinchmann@nord.no. AD - Faculty of Nursing and Health Sciences, Nord University, Postbox 1490, 8049, Bodo, Norway. berit.s.brinchmann@nord.no. FAU - Sorstrom, Anne Kristine AU - Sorstrom AK AUID- ORCID: 0000-0001-6027-3201 AD - Nordland Hospital Trust, Bodo, Norway. FAU - Jacobsen, Lisa Marie AU - Jacobsen LM AUID- ORCID: 0009-0000-5190-2475 AD - Faculty of Nursing and Health Sciences, Nord University, Levanger, Norway. FAU - Ytterstad, Gro Anita AU - Ytterstad GA AD - Regional Centre for Eating Disorders, Nordland Hospital Trust, Bodo, Norway. FAU - Trichet, Laurent Olivier AU - Trichet LO AUID- ORCID: 0009-0007-3272-8468 AD - Nordland Hospital Trust, Bodo, Norway. LA - eng PT - Journal Article DEP - 20260806 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13487969 OAB - EDs affect not only the person who is ill but also their whole family. Many parents and siblings feel confused, worried, and unsure how to help. Multifamily therapy (MFT) brings several families together to learn, share experiences, and support each other. In this study, we explored how young adult women with an ED and their families experienced participating in a MFT programme in Norway. We combined interviews with patients and family members, and questionnaires completed before and after the programme. Participants described MFT as helpful because it gave them new ways to understand the illness and talk about difficult topics. Creative exercises and shared discussions helped families see the ED as something separate from the person and facilitated communication and mutual understanding. The questionnaires showed that patients felt less anxious and less unhappy with their body shape, while family members felt less guilt, stress, and need to adapt their lives around the illness. Overall, the findings suggest that MFT can be a valuable form of support for young adults with an ED and their families, helping them feel less alone and better equipped to cope together. OABL- eng OTO - NOTNLM OT - Adults OT - Descriptive OT - Eating disorder OT - Multifamily therapy COIS- Declarations. Ethics approval and consent to participate: The study was approved by a Regional Committee for Medical and Health Research Ethics (No. 2014/1621/No. 655808). Each participant received oral and written information about the study and signed a consent form. They were also informed that they could withdraw from the study at any time. The data were treated confidentially and anonymised. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/20 05:43 MHDA- 2026/08/20 05:44 PMCR- 2026/08/06 CRDT- 2026/08/20 00:31 PHST- 2026/01/30 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/20 05:44 [medline] PHST- 2026/08/20 05:43 [pubmed] PHST- 2026/08/20 00:31 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.1186/s40337-026-01730-7 [pii] AID - 1730 [pii] AID - 10.1186/s40337-026-01730-7 [doi] PST - epublish SO - J Eat Disord. 2026 Aug 6;14(1):193. doi: 10.1186/s40337-026-01730-7. PMID- 42618859 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Aug 19 TI - Bioelectrical impedance analysis versus dual-energy X-ray absorptiometry for body composition assessment in children with chronic kidney disease. LID - 679 [pii] LID - 10.1007/s00431-026-07355-x [doi] AB - INTRODUCTION: Children with chronic kidney disease (CKD) exhibit progressive body composition alterations. While dual-energy X-ray absorptiometry (DXA) is the reference standard, its routine use is limited by cost, radiation, and availability. Bioelectrical impedance analysis (BIA) offers a portable, radiation-free alternative, but its accuracy relative to DXA in paediatric CKD remains insufficiently evaluated. METHODS: This cross-sectional study enrolled 102 children aged 5-14 years with CKD stages 3-5. Same-day BIA and DXA measurements were performed. Agreement between methods was assessed using Pearson's correlation coefficient, Lin's concordance correlation coefficient (CCC), and Bland-Altman analysis. Associations with CKD stage and sex were examined. RESULTS: BIA showed strong to very strong correlations with DXA for fat mass (FM; r = 0.93), fat-free mass (FFM; r = 0.91), and total bone mineral content (BMC; r = 0.84). Lin's CCC indicated poor concordance for all parameters (all < 0.90): FFM 0.87, total BMC 0.81, total bone mineral density (BMD) 0.74, FM 0.66 and body fat percentage (BF%) 0.29. BIA systematically underestimated FM and overestimated FFM relative to DXA. DXA detected significant stage-wise reductions in FM, FMI, FFM and FFMI across CKD stages, whereas BIA detected only the decline in FFMI (p = 0.012). CONCLUSIONS: Despite strong correlations, BIA showed poor concordance with DXA for every parameter assessed, with clinically unacceptable limits of agreement; correlation does not imply interchangeability. BIA may retain a role in population-level nutritional screening in resource-limited settings, although its ability to track change was not tested here; DXA remains necessary for individual-level assessment in paediatric CKD. What is known * Children with CKD experience progressive lean tissue loss, fat redistribution, and impaired bone mineralisation contributing to growth failure. * DXA is the reference standard for body composition assessment, but it is limited by cost, radiation, and availability. What is new * BIA shows a strong to very strong correlation with DXA but poor concordance (Lin's CCC < 0.90) for every body composition and bone parameter in paediatric CKD stages 3-5. * BIA cannot detect stage-wise differences in body composition that DXA identifies, limiting its diagnostic precision in this population. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Karri, Madhu Sudhan AU - Karri MS AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Dawman, Lesa AU - Dawman L AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. lesadawman@gmail.com. FAU - Sadasivam, Deepthika AU - Sadasivam D AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Vallabhaneni, Pujitha AU - Vallabhaneni P AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Mahajan, Shailza AU - Mahajan S AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Singh, Tulika AU - Singh T AD - Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Kaur, Harvinder AU - Kaur H AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Yadav, Jaivinder AU - Yadav J AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Tiewsoh, Karalanglin AU - Tiewsoh K AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260819 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - *Absorptiometry, Photon/methods MH - Female MH - Male MH - Cross-Sectional Studies MH - *Electric Impedance MH - Adolescent MH - *Body Composition MH - *Renal Insufficiency, Chronic/physiopathology MH - Child, Preschool MH - Bone Density MH - Reproducibility of Results OTO - NOTNLM OT - Bioelectrical impedance analysis OT - Body composition OT - Bone mineral density OT - Children OT - Chronic kidney disease OT - Dual-energy X-ray absorptiometry COIS- Declarations. Ethical approval: All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee at which the study was conducted (Institutional Ethics Committee, Post Graduate Institute of Medical Education and Research, Chandigarh, India, IEC approval number: No.IEC-INT/2024/MD-1684, dated: 16.03.2024) and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent: Written informed consent was obtained from all parents or legal guardians prior to enrolment. Conflicts of interest: None of the authors has any disclosures or conflicts of interest concerning this article's research, authorship, or publication. EDAT- 2026/08/20 05:43 MHDA- 2026/08/20 05:44 CRDT- 2026/08/20 00:15 PHST- 2026/06/09 00:00 [received] PHST- 2026/08/16 00:00 [accepted] PHST- 2026/07/24 00:00 [revised] PHST- 2026/08/20 05:44 [medline] PHST- 2026/08/20 05:43 [pubmed] PHST- 2026/08/20 00:15 [entrez] AID - 10.1007/s00431-026-07355-x [pii] AID - 10.1007/s00431-026-07355-x [doi] PST - epublish SO - Eur J Pediatr. 2026 Aug 19;185(9):679. doi: 10.1007/s00431-026-07355-x. PMID- 42617758 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260910 IS - 1532-3064 (Electronic) IS - 0954-6111 (Linking) VI - 262 DP - 2026 Oct TI - Lung ultrasound in children with cystic fibrosis: A descriptive clinical study. PG - 109113 LID - S0954-6111(26)00482-8 [pii] LID - 10.1016/j.rmed.2026.109113 [doi] AB - BACKGROUND: Longer life expectancy in cystic fibrosis (CF) has intensified concerns about cumulative radiation exposure from repeated imaging. High-resolution computed tomography (HRCT) remains essential for detecting deeper structural abnormalities, but there is growing interest in radiation-free tools capable of providing reliable and repeatable lung assessments. Lung ultrasound (LUS) has emerged as a promising adjunct technique, yet its role in routine paediatric CF follow-up and during pulmonary exacerbations remains incompletely defined. METHODS: We conducted a single-centre retrospective study including paediatric patients with CF who underwent LUS between 2021 and 2025. A standardised 12-zone protocol and a LUS score (0-36) were applied. LUS findings were correlated with clinical variables and lung function (Forced Expiratory Volume in 1 s, FEV1). Comparisons with chest radiography and HRCT were performed when available. In a subgroup, paired LUS examinations during pulmonary exacerbations were analysed. RESULTS: Thirty-five children were included (median age 10.0 years). LUS abnormalities were identified in 68% of patients, most frequently isolated B-lines and small subpleural consolidations. No significant differences in lesion distribution were observed across anatomical regions. The LUS score showed a strong negative correlation with FEV1% predicted (rho = -0.655, p < 0.001) and was associated with BMI z-score (rho = -0.694, p < 0.001) and exacerbation burden (rho = 0.431, p = 0.010). Children receiving CFTR modulator therapy had significantly lower LUS scores (p = 0.021). Compared with chest radiography, LUS detected additional abnormalities in 27% of examinations with apparently normal radiographs. LUS reliably identified all clinically relevant consolidations detected in CT, but CT remained superior for proximal lesions, which are not accessible by LUS. In the exacerbation subgroup, LUS could track real-time disease evolution. CONCLUSION: LUS is a practical, repeatable, and radiation-free point-of-care imaging tool that offers clinically relevant information in children with CF. It correlates with functional impairment, detects abnormalities not visible on radiography, and may support monitoring during exacerbations. While CT remains essential for complete structural assessment, LUS may help reduce unnecessary radiographic exposure and extend CT surveillance intervals, positioning it as a valuable complementary tool in modern CF care. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Giraudi, Stefano AU - Giraudi S AD - Department of Paediatrics and Public Health, Regina Margherita Children's Hospital, University of Turin, Citta della Salute e della Scienza, Turin, 10126, Italy. FAU - Epaud, Ralph AU - Epaud R AD - Paediatric Department, Centre Hospitalier Intercommunal de Creteil and Reference Centre for Rare Lung Diseases (RespiRare), Creteil, France; INSERM U955 (IMRB), Universite Paris Est Creteil (UPEC), Creteil, France. FAU - Delestrain, Celine AU - Delestrain C AD - Paediatric Department, Centre Hospitalier Intercommunal de Creteil and Reference Centre for Rare Lung Diseases (RespiRare), Creteil, France; INSERM U955 (IMRB), Universite Paris Est Creteil (UPEC), Creteil, France. FAU - Remus, Natascha AU - Remus N AD - Paediatric Department, Centre Hospitalier Intercommunal de Creteil and Reference Centre for Rare Lung Diseases (RespiRare), Creteil, France; INSERM U955 (IMRB), Universite Paris Est Creteil (UPEC), Creteil, France. FAU - Shum, Mickael AU - Shum M AD - Paediatric Department, Centre Hospitalier Intercommunal de Creteil and Reference Centre for Rare Lung Diseases (RespiRare), Creteil, France; INSERM U955 (IMRB), Universite Paris Est Creteil (UPEC), Creteil, France. Electronic address: mickael.shum@chicreteil.fr. LA - eng PT - Journal Article DEP - 20260819 PL - England TA - Respir Med JT - Respiratory medicine JID - 8908438 SB - IM MH - Humans MH - *Cystic Fibrosis/diagnostic imaging/physiopathology MH - Child MH - Ultrasonography/methods MH - Retrospective Studies MH - Male MH - Female MH - *Lung/diagnostic imaging/physiopathology MH - Tomography, X-Ray Computed/methods MH - Adolescent MH - Forced Expiratory Volume MH - Child, Preschool OTO - NOTNLM OT - Cystic fibrosis OT - Exacerbations OT - Lung imaging OT - Lung ultrasound COIS- Declaration of competing interests None. EDAT- 2026/08/19 23:42 MHDA- 2026/09/10 23:36 CRDT- 2026/08/19 19:11 PHST- 2026/05/26 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/10 23:36 [medline] PHST- 2026/08/19 23:42 [pubmed] PHST- 2026/08/19 19:11 [entrez] AID - S0954-6111(26)00482-8 [pii] AID - 10.1016/j.rmed.2026.109113 [doi] PST - ppublish SO - Respir Med. 2026 Oct;262:109113. doi: 10.1016/j.rmed.2026.109113. Epub 2026 Aug 19. PMID- 42617192 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260822 IS - 1598-6357 (Electronic) IS - 1011-8934 (Print) IS - 1011-8934 (Linking) VI - 41 IP - 32 DP - 2026 Aug 17 TI - Twin Birth Weight Chart Comparisons in Korea. PG - e215 LID - 10.3346/jkms.2026.41.e215 [doi] LID - e215 AB - BACKGROUND: Birth weight deviations from gestational age-specific standards affect neonatal outcomes. While singleton references are established, their applicability to twins is debated. With the increasing incidence of twin and preterm births, twin-specific growth standards remain limited in Korea. This study systematically analyzed twin growth trajectories, considering sex, mode of conception, and chorionicity, to establish accurate references. METHODS: This study analyzed data from the Korean Neonatal Network (2013-2020; /=5 years) follow-up outcomes were assessed using subjective visual analog scale and objective anthropometric analysis. The anthropometric indices include 8 ratios and 3 angle measurements. RESULTS: Forty-eight patients were included in this retrospective study. The median follow-up period was 6.01 years (range, 5.06 to 12.01 years). Subjective assessments showed positive aesthetic outcomes, with minimal scarring and improved symmetry. Long-term postoperative anthropometric measurements demonstrated significant improvements in the symmetry of alar, nostril, columella, nasal sill, philtrum, and vermilion. CONCLUSIONS: According to the 19 years of experience of the authors, the nasolabial muscle tension line group reconstruction technique is effective for repairing microform cleft lip deformities, offering significant improvements in nasal and labial symmetry. This technique ensures reliable formation of the philtrum and nasal sill through precise reconstruction of muscle tension line groups. Long-term follow-up assessments using this technique revealed sustained nasolabial symmetry over time. CI - Copyright (c) 2025 by the American Society of Plastic Surgeons. FAU - Liu, Xuanchen AU - Liu X AD - From the Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. FAU - Zheng, Yilue AU - Zheng Y AD - From the Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. FAU - Jiang, Chanyuan AU - Jiang C AD - From the Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. FAU - Ma, Hengyuan AU - Ma H AD - From the Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. FAU - Wu, Di AU - Wu D AD - From the Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. FAU - Song, Tao AU - Song T AD - From the Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. FAU - Wang, Yongqian AU - Wang Y AD - From the Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. FAU - Yin, Ningbei AU - Yin N AD - From the Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. LA - eng PT - Journal Article DEP - 20251203 PL - United States TA - Plast Reconstr Surg JT - Plastic and reconstructive surgery JID - 1306050 SB - IM MH - Humans MH - *Cleft Lip/surgery MH - Retrospective Studies MH - Female MH - Male MH - Treatment Outcome MH - Follow-Up Studies MH - *Plastic Surgery Procedures/methods MH - Esthetics MH - Child MH - Adolescent MH - Facial Muscles/surgery MH - Lip/surgery MH - Time Factors MH - Adult MH - Young Adult MH - Child, Preschool EDAT- 2026/08/19 14:49 MHDA- 2026/09/29 19:03 CRDT- 2026/08/19 08:53 PHST- 2026/09/29 19:03 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 08:53 [entrez] AID - 00006534-990000000-02944 [pii] AID - 10.1097/PRS.0000000000012674 [doi] PST - ppublish SO - Plast Reconstr Surg. 2026 Oct 1;158(4):663e-672e. doi: 10.1097/PRS.0000000000012674. Epub 2025 Dec 3. PMID- 42615265 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260909 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 17 IP - 4 DP - 2026 Aug TI - Normative Reference Values and Cut-Off Points for Nutritional Ultrasound: The VALORES Study. PG - e70344 LID - 10.1002/jcsm.70344 [doi] LID - e70344 AB - BACKGROUND: Nutritional ultrasound (NU) enables direct assessment of skeletal muscle and adipose tissue, yet population-based reference values and cut-offs remain scarce. We aimed to establish age- and sex-specific normative values for rectus femoris (RF) and abdominal adipose tissue NU measurements in apparently healthy adults. METHODS: Multicentre cross-sectional study of 1789 healthy blood donors (842 women, 947 men), aged 18-80 years (mean 41.5 +/- 14.9). Standardised NU assessed RF cross-sectional area (CSA), circumference, transverse (X) and anteroposterior (Y) axes, and abdominal and thigh adipose tissue. Anthropometry, bioelectrical impedance analysis (BIA) and handgrip strength (HGS) were obtained. Age- and sex-specific percentiles were generated across predefined age groups (18-30, 31-45, 46-60 and > 60 years). T-scores for RF parameters were derived from a young reference subgroup aged 18-45 years (n = 1001). Associations with sex, age, body mass index and physical activity were analysed. RESULTS: All NU parameters differed significantly by sex (all p < 0.001). Median RF-CSA was 4.60 cm(2) (IQR 3.83-5.58) in women and 6.77 cm(2) (5.55-7.91) in men; median RF-Y axis at rest was 1.56 cm (1.33-1.80) and 1.91 cm (1.65-2.17), and during contraction 1.97 cm (1.71-2.24) and 2.47 cm (2.15-2.78), respectively. Median total abdominal subcutaneous adipose tissue (T-SAT) was 1.77 cm (1.16-2.39) in women and 1.65 cm (1.13-2.22) in men. RF measurements correlated moderately-strongly with BIA-derived muscle mass (r = 0.45-0.65) and HGS (r = 0.49-0.58). T-SAT correlated with BIA fat mass and waist circumference (r = 0.45-0.65), whereas visceral adipose tissue showed weaker associations (r approximately 0.33). RF-CSA and RF-Y axis increased across physical-activity categories (p < 0.05). Absolute RF values did not differ by BMI; however, when indexed to body weight, participants with BMI > 25 kg/m(2) had lower RF-CSA and RF-Y values (all p < 0.001). RF parameters followed a normal distribution, whereas adipose tissue measures did not. In the young reference group (18-45 years), mean +/- SD RF-Y axis was 1.68 +/- 0.33 cm in women and 2.05 +/- 0.37 cm in men. When applying T-score criteria, the -2 standard deviation cut-off identified 1.4%-11.7% of adults aged >/=45 years as having low muscle mass. CONCLUSIONS: This study provides the first age- and sex-specific population-based reference values for nutritional ultrasound measurements in an apparently healthy adult Spanish population. These findings support the validity, clinical applicability, and standardisation of nutritional ultrasound for the assessment of muscle mass, with potential utility in the diagnosis of sarcopenia and malnutrition. CI - (c) 2026 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Moreno-Torres-Taboada, Carolina AU - Moreno-Torres-Taboada C AUID- ORCID: 0009-0002-2768-8151 AD - Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. FAU - Romero-Marquez, Jose M AU - Romero-Marquez JM AD - Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. AD - Foundation for Biosanitary Research of Eastern Andalusia - Alejandro Otero (FIBAO), Granada, Spain. AD - Faculty of Health Sciences. Department of Nutrition and Sports Sciences, International University of La Rioja, Logrono, Spain. FAU - Garcia-Olivares, Maria AU - Garcia-Olivares M AD - Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, QuironSalud Malaga Hospital, Malaga, Spain. FAU - Novo-Rodriguez, Maria AU - Novo-Rodriguez M AD - Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. AD - Foundation for Biosanitary Research of Eastern Andalusia - Alejandro Otero (FIBAO), Granada, Spain. FAU - Fernandez-Jimenez, Rocio AU - Fernandez-Jimenez R AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, QuironSalud Malaga Hospital, Malaga, Spain. AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain. FAU - Vegas-Aguilar, Isabel AU - Vegas-Aguilar I AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain. FAU - Garcia-Luna, Pedro Pablo AU - Garcia-Luna PP AD - Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FAU - Garcia-Rey, Silvia AU - Garcia-Rey S AD - Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FAU - Garcia-Almeida, Jose Manuel AU - Garcia-Almeida JM AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, QuironSalud Malaga Hospital, Malaga, Spain. AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain. AD - Network Biomedical Research Center Physiopathology of Obesity and Nutrition (CiberOBN), Carlos III Health Institute, Madrid, Spain. FAU - Olveira, Gabriel AU - Olveira G AD - Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Instituto de Salud Carlos III, Malaga, Spain. CN - VALORES Group LA - eng GR - C24051/Fresenius Kabi/ PT - Journal Article PT - Multicenter Study PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - Reference Values MH - Aged MH - Ultrasonography/methods MH - Adolescent MH - Aged, 80 and over MH - Young Adult MH - Cross-Sectional Studies MH - Body Composition MH - *Muscle, Skeletal/diagnostic imaging/physiology MH - Adipose Tissue/diagnostic imaging PMC - PMC13487697 OTO - NOTNLM OT - body composition OT - malnutrition OT - muscle ultrasound OT - nutritional ultrasound OT - reference values OT - sarcopenia COIS- The authors declare no conflicts of interest. FIR - The Valores Group, For IR - The Valores Group F FIR - Lopez-de-la-Torre-Casares, Martin IR - Lopez-de-la-Torre-Casares M IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Munoz-Garach, Araceli IR - Munoz-Garach A IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Novo-Rodriguez, Cristina IR - Novo-Rodriguez C IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Guardia-Baena, Juan Manuel IR - Guardia-Baena JM IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Padial-Barranco, Marina IR - Padial-Barranco M IRAD- Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. FIR - Porras-Perez, Nuria IR - Porras-Perez N IRAD- Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. FIR - Rojo-Martinez, Gemma IR - Rojo-Martinez G IRAD- Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. FIR - Del Carmen Roque-Cuellar, Maria IR - Del Carmen Roque-Cuellar M IRAD- Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FIR - Jimenez-Sanchez, Andres IR - Jimenez-Sanchez A IRAD- Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FIR - Martinez-Ortega, Antonio Jesus IR - Martinez-Ortega AJ IRAD- Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/19 CRDT- 2026/08/19 06:13 PHST- 2026/06/18 00:00 [revised] PHST- 2026/02/18 00:00 [received] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 06:13 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - JCSM70344 [pii] AID - 10.1002/jcsm.70344 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2026 Aug;17(4):e70344. doi: 10.1002/jcsm.70344. PMID- 42614979 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260819 LR - 20260820 IS - 2253-5969 (Print) IS - 2253-5969 (Electronic) IS - 2253-5969 (Linking) VI - 13 DP - 2026 TI - Prognostic Factors Analysis in Patients with Hepatocellular Carcinoma Receiving PD-1/PD-L1 Inhibitors. PG - 623481 LID - 10.2147/JHC.S623481 [doi] LID - 623481 AB - BACKGROUND: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced hepatocellular carcinoma (HCC); however, only a minority of patients derive benefits, and reliable biomarkers remain lacking. This study aimed to investigate the associations between peripheral blood markers, clinical characteristics, and outcomes in patients receiving programmed cell death protein-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors. METHODS: Clinical and laboratory data from 101 patients treated with PD‑1/PD‑L1 inhibitors were retrospectively analyzed. Optimal cutoff values for continuous variables were determined using the X‑tile. Intergroup comparisons were performed using Pearson's chi-squared or Fisher's exact tests. Univariate Cox regression (SPSS 26.0) was used to identify potential prognostic factors (P<0.1), which were further evaluated by Log rank test and Kaplan-Meier curves. Independent prognostic factors were determined using a multivariate Cox regression analysis. RESULTS: The factors associated with efficacy included body mass index, Child‑Pugh class, line of treatment, distant metastasis, bone metastasis, alkaline phosphatase, and total bilirubin. Prognosis‑related indicators included lung metastasis, hemoglobin, absolute neutrophil count, alkaline phosphatase, gamma‑glutamyl transferase, C‑reactive protein, and the best response. CONCLUSION: Based on routine clinical and hematological data, this prognostic study provides an accessible tool for personalized immunotherapy management of HCC. CI - (c) 2026 Pan et al. FAU - Pan, Yubin AU - Pan Y AD - Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, People's Republic of China. FAU - Li, Qijun AU - Li Q AD - Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310020, People's Republic of China. FAU - Tang, Honglin AU - Tang H AD - Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310020, People's Republic of China. FAU - Chen, Guangpeng AU - Chen G AD - Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310020, People's Republic of China. FAU - Li, Da AU - Li D AUID- ORCID: 0000-0003-2968-3813 AD - Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310020, People's Republic of China. LA - eng PT - Journal Article DEP - 20260814 PL - New Zealand TA - J Hepatocell Carcinoma JT - Journal of hepatocellular carcinoma JID - 101674775 PMC - PMC13484642 OTO - NOTNLM OT - hepatocellular carcinoma OT - immunotherapy OT - prognostic factors OT - survival analysis OT - treatment outcome COIS- The authors declare that there is no conflicts of interest in this work. EDAT- 2026/08/19 14:48 MHDA- 2026/08/19 14:49 PMCR- 2026/08/14 CRDT- 2026/08/19 06:00 PHST- 2026/05/11 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/19 14:49 [medline] PHST- 2026/08/19 14:48 [pubmed] PHST- 2026/08/19 06:00 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 623481 [pii] AID - 10.2147/JHC.S623481 [doi] PST - epublish SO - J Hepatocell Carcinoma. 2026 Aug 14;13:623481. doi: 10.2147/JHC.S623481. eCollection 2026. PMID- 42614440 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260820 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - A community-based educational initiative to support awareness of relative energy deficiency in sport among adolescent athletes. PG - 1868398 LID - 10.3389/fpubh.2026.1868398 [doi] LID - 1868398 AB - Relative Energy Deficiency in Sport (REDs) is a syndrome caused by chronic low energy availability (LEA) and can disrupt hormonal, metabolic and psychological functioning. Adolescents are particularly vulnerable because they are still growing, have high energy requirements and are susceptible to sociocultural pressures. Despite increasing scientific attention, awareness and prevention of REDs remain insufficient in everyday sport settings. This community case study describes the Energy for Long-Term Health initiative, implemented in 2025-2026 in the Czech Republic across six sports-focused secondary schools ( approximately 300 students, aged 15-19 years). Each school received an interactive workshop (60-120 min) structured into four blocks: (1) explanation of energy availability and its practical implications; (2) consequences of LEA for health and performance; (3) recognition of warning signs and risk situations; and (4) preventive strategies and the role of the support team. Secondary target groups included coaches, teachers and parents, who were engaged through reusable visual materials and online dissemination via the online platform. Key lessons were that adolescent REDs education requires age-appropriate language, opportunities for anonymous questions and careful facilitation of sensitive topics. Combining face-to-face workshops with online resources extended reach and reinforced key messages. Although no formal evaluation of effectiveness was conducted, high attendance and positive informal feedback suggest that university-supported community initiatives can enhance awareness of REDs among young athletes and their support networks. Future applications should incorporate formal needs assessments, systematic evaluation, and validated measures of knowledge and behaviour change. CI - Copyright (c) 2026 Cizlerova and Hlinsky. FAU - Cizlerova, Nikola AU - Cizlerova N AD - Faculty of Sports Studies, Masaryk University, Brno, Czechia. FAU - Hlinsky, Tomas AU - Hlinsky T AD - Faculty of Sports Studies, Masaryk University, Brno, Czechia. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Athletes/education MH - *Relative Energy Deficiency in Sport/prevention & control MH - Czech Republic MH - Female MH - *Health Education/methods MH - Sports PMC - PMC13481860 OTO - NOTNLM OT - adolescent athletes OT - community education OT - low energy availability OT - prevention OT - sports nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/04 CRDT- 2026/08/19 05:16 PHST- 2026/04/29 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 05:16 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1868398 [doi] PST - epublish SO - Front Public Health. 2026 Aug 4;14:1868398. doi: 10.3389/fpubh.2026.1868398. eCollection 2026. PMID- 42614353 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260819 LR - 20260820 IS - 2673-3153 (Electronic) IS - 2673-3153 (Print) IS - 2673-3153 (Linking) VI - 8 DP - 2026 TI - The value of anti-Mullerian hormone for diagnosing polycystic ovary syndrome in adolescents: a case-control study based on an epidemiological survey. PG - 1907699 LID - 10.3389/frph.2026.1907699 [doi] LID - 1907699 AB - BACKGROUND: Updated 2023 international evidence-based guidelines do not recommend anti-Mullerian hormone (AMH) for diagnosing adolescent polycystic ovary syndrome (PCOS, also newly termed polyendocrine metabolic ovarian syndrome [PMOS]) due to limited specificity. Physiological multifollicular ovaries are prevalent in teenagers, and existing studies show massive heterogeneity in participant age, BMI, AMH detection platforms and cut-off thresholds without unified adolescent-specific standards. This study aimed to analyze serum AMH correlations with core adolescent PCOS phenotypes and evaluate the auxiliary diagnostic performance of AMH for adolescent PCOS. METHODS: Based on a cross-sectional school-based epidemiological survey among adolescent girls aged 14-18 years, we enrolled 211 healthy girls, 158 girls with oligo-/amenorrhea, 38 girls with isolated clinical hirsutism, 51 girls with isolated biochemical hyperandrogenemia, and 39 adolescent PCOS patients for case-control analysis. Pearson's correlation coefficients were calculated to determine the correlations between AMH and various parameters. Receiver Operating Characteristic (ROC) curve analysis was performed to examine the diagnostic performance of AMH. RESULTS: Serum AMH concentrations were significantly higher in girls with oligo-/amenorrhea and isolated biochemical hyperandrogenemia relative to healthy controls (P < 0.05), while isolated hirsutism presented comparable AMH levels with controls (P > 0.05). Adolescent PCOS patients had the highest AMH levels among all subgroups (P < 0.05). AMH was positively correlated with all circulating androgen markers (T, FAI, A2, fT, DHEAS) but showed no correlation with age, menarcheal age, gynecological age, BMI, WHR or SHBG. Within the PCOS cohort, only serum testosterone maintained an independent positive correlation with AMH (r = 0.450, P = 0.004). ROC analysis showed an AUC of AMH for adolescent PCOS of 0.717 (95%CI: 0.625-0.809, P < 0.001). Bootstrap-validated optimal AMH cut-off value was 4.0 ng/mL, with sensitivity 51.3% (95CI: 35.4%-67.2%) and specificity 86.1% (95CI: 81.2%-90.0%). post-hoc power analysis demonstrated moderate statistical power of 0.74 for this ROC model due to limited PCOS sample size (n = 39). CONCLUSIONS: Serum AMH is closely correlated with two core diagnostic manifestations of adolescent PCOS: ovulatory dysfunction and biochemical hyperandrogenemia. Nevertheless, the low sensitivity of the 4.0 ng/mL threshold leads to nearly half missed PCOS cases if used alone for screening. Combined with inherent incorporation bias, absence of ovarian ultrasound data and consistent 2023 guideline recommendations, AMH can only serve as an adjunctive auxiliary biomarker rather than an independent diagnostic or screening tool for adolescent PCOS. Multicenter studies with standardized ovarian ultrasonography and external validation cohorts are required to establish generalizable age-specific AMH cut-offs for adolescents. CI - (c) 2026 Hong, Li, Yang, Zhou and Dong. FAU - Hong, Yu AU - Hong Y AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. AD - Department of Obstetrics and Gynecology, Kiangwu Hospital, Macao SAR, China. FAU - Li, Enping AU - Li E AD - Department of Obstetrics and Gynecology, Kiangwu Hospital, Macao SAR, China. FAU - Yang, Dongzi AU - Yang D AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. FAU - Zhou, Zehong AU - Zhou Z AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. FAU - Dong, Zhe AU - Dong Z AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Front Reprod Health JT - Frontiers in reproductive health JID - 9918230899006676 PMC - PMC13481504 OTO - NOTNLM OT - adolescence OT - anti-Mullerian hormone OT - auxiliary diagnostic biomarker OT - polycystic ovary syndrome OT - polyendocrine metabolic ovarian syndrome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/04 CRDT- 2026/08/19 05:07 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 05:07 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.3389/frph.2026.1907699 [doi] PST - epublish SO - Front Reprod Health. 2026 Aug 4;8:1907699. doi: 10.3389/frph.2026.1907699. eCollection 2026. PMID- 42614308 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260819 LR - 20260820 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Gut microbiota of sprint athletes: signature microbes and dietary links. PG - 1855417 LID - 10.3389/fnut.2026.1855417 [doi] LID - 1855417 AB - BACKGROUND: The gut microbiota has emerged as an important biological factor associated with host physiological status in athletes. However, relevant research remains limited for sprint athletes, whose physiological demands differ substantially from those of endurance athletes. OBJECTIVE: This study aimed to characterize the gut microbiota profile of college sprint athletes, compare it with non-athletic peers, identify potential sprint-associated bacterial taxa, and explore diet-microbiota associations to propose potential nutritional hypotheses for these signature taxa. METHODS: Fecal samples were collected from 20 college sprint athletes and 23 non-athletic college students for metagenomic sequencing. Dietary intake was assessed using a validated food frequency questionnaire. Alpha and beta diversity analyses were performed to evaluate microbial community diversity and structure. LEfSe was used to identify differentially abundant taxa. Functional annotation and enrichment were conducted using KEGG, GO, and other databases. Spearman's correlation was applied to examine diet-microbiota relationships. RESULTS: Alpha diversity indices (Shannon, Chao1, etc.) did not differ significantly between groups. In contrast, beta diversity analysis revealed significant structural separation. LEfSe identified Segatella copri (LDA = 4.986, p = 0.017) and Bifidobacterium adolescentis (LDA = 3.154, p = 0.003) as signature taxa in athletes, both with significantly higher abundance than in non-athletes. Functional analysis showed predicted enrichment of pathways related to energy metabolism (carbohydrate metabolism, ATP binding) and amino acid metabolism in athletes. Correlation analysis indicated that S. copri abundance was nominally positively associated with dairy intake (r = 0.31, p = 0.045), while B. adolescentis was nominally associated with whole grains, soy milk/soy powder, and dairy products. CONCLUSION: College sprint athletes possess a distinct gut microbiota structure compared with non-athletes. S. copri and B. adolescentis represent distinct microbial signatures associated with sprint athletes, accompanied by corresponding predicted functional pathway enrichment. Specific dietary patterns, including the intake of whole grains, soy milk/soy powder, and dairy products, exhibit exploratory nominal associations with the signature gut microbiota composition of sprinters. CI - Copyright (c) 2026 Su, Lan, Chen and Wang. FAU - Su, Chuanjian AU - Su C AD - Clinical Medical College of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China. FAU - Lan, Jinfeng AU - Lan J AD - Army Arms University of PLA, Hefei, Anhui, China. FAU - Chen, Huimin AU - Chen H AD - The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China. FAU - Wang, Daoming AU - Wang D AD - School of Physical Education and Health, Anhui Medical University, Hefei, Anhui, China. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13481514 OTO - NOTNLM OT - college students OT - diet-microbiota interaction OT - gut microbiota OT - metagenomic sequencing OT - sprint athletes OT - sprint-associated bacteria COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/04 CRDT- 2026/08/19 05:00 PHST- 2026/04/14 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 05:00 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.3389/fnut.2026.1855417 [doi] PST - epublish SO - Front Nutr. 2026 Aug 4;13:1855417. doi: 10.3389/fnut.2026.1855417. eCollection 2026. PMID- 42613030 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260926 IS - 1464-3685 (Electronic) IS - 0300-5771 (Print) IS - 0300-5771 (Linking) VI - 55 IP - 5 DP - 2026 Aug 18 TI - Elucidating the proteomic pathways linking childhood body mass index with type 2 diabetes: a Mendelian randomization and recall-by-genotype study. LID - 10.1093/ije/dyag165 [doi] LID - dyag165 AB - BACKGROUND: Increased childhood adiposity contributes to higher type 2 diabetes (T2D) risk, but the underlying mechanisms remain unclear. Furthermore, whether these mechanistic pathways are shared across ethnic groups has not been explored. METHODS: We conducted a two-step Mendelian randomization (MR) using European-based summary statistics from genome-wide association studies of childhood body mass index (BMI) (n = 61 111), adulthood proteomics (n = 35 559), and later life T2D (cases: 242 283; controls: 1 569 734). We also conducted a recall-by-genotype (RbG) study in a Chinese birth cohort (n = 250) to assess whether childhood BMI was associated with the identified proteomic signals in an East Asian population. Analyses included multi-instrument MR methods (inverse variance weighted and MR-Egger) and, for single-instrument proteins, cis-MR using the Wald ratio, with colocalization validation. Multiple testing was adjusted using false discovery rate (FDR). RESULTS: Higher genetically predicted childhood BMI was associated with 1299 proteins (FDR-adjusted P < .05), of which 36 proteins were associated with higher T2D risk. Six proteins were supported by colocalization (PPH4 > 80%). Genetically predicted higher childhood BMI was positively associated with GCKR, RBP1, ENTPD6, and GST A1-1, and inversely associated with PRSS27 and SHBG. The proportion of the BMI-T2D effect mediated by these proteins ranged from 1.87% to 12.92%. However, only SHBG was replicated in Asians in the RbG study. CONCLUSIONS: Our study identified putative actionable proteins that could reduce the elevated T2D risk attributable to childhood adiposity in Europeans, but their relevance in Asian populations requires further investigation. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the International Epidemiological Association. FAU - Chen, Siyu AU - Chen S AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Liang, Yiwen AU - Liang Y AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Luo, Shan AU - Luo S AUID- ORCID: 0000-0003-3368-9935 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Zheng, Jie AU - Zheng J AUID- ORCID: 0000-0002-4265-6695 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yoshiji, Satoshi AU - Yoshiji S AD - Department of Human Genetics, McGill University, Montreal, QC, Canada. FAU - Power, Grace M AU - Power GM AUID- ORCID: 0000-0002-5702-7728 AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom. AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. AD - Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. FAU - Xu, Zikun AU - Xu Z AD - Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom. FAU - Burgess, Stephen AU - Burgess S AUID- ORCID: 0000-0001-5365-8760 AD - MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, United Kingdom. FAU - Cowling, Benjamin John AU - Cowling BJ AUID- ORCID: 0000-0002-6297-7154 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Lam, Hugh Simon AU - Lam HS AD - Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Li, Albert Martin AU - Li AM AD - Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Leung, Gabriel Matthew AU - Leung GM AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Schooling, Catherine Mary AU - Schooling CM AUID- ORCID: 0000-0001-9933-5887 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. AD - Graduate School of Public Health and Health Policy, City University of New York, New York, NY, United States. FAU - Au Yeung, Shiu Lun AU - Au Yeung SL AUID- ORCID: 0000-0001-6136-1836 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. LA - eng GR - 216106/Health Care and Promotion Fund, Health and Welfare Bureau, Government of the Hong Kong SAR/ GR - 03040771/Health and Health Services Research Fund/ GR - 05060671/Health and Health Services Research Fund/ GR - 07080751/Health and Health Services Research Fund/ GR - 07080841/Health and Health Services Research Fund/ PT - Journal Article PL - England TA - Int J Epidemiol JT - International journal of epidemiology JID - 7802871 RN - Chinese people SB - IM MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - *Body Mass Index MH - *Diabetes Mellitus, Type 2/genetics/metabolism MH - Genome-Wide Association Study MH - Genotype MH - Mendelian Randomization Analysis MH - *Pediatric Obesity/genetics/metabolism MH - Polymorphism, Single Nucleotide MH - Proteomics MH - White People/genetics MH - East Asian People/genetics MH - Genetic Predisposition to Disease PMC - PMC13485351 OTO - NOTNLM OT - childhood obesity OT - proteomics OT - type 2 diabetes COIS- S.L.A.Y. received honoraria from Standard BioTools for scientific presentations on proteomic studies that was related to this study. However, Standard BioTools was not involved in the study design and data analysis of this study. S.B. and C.M.S. serve as editors of the International Journal of Epidemiology, but were not involved in the review, editorial assessment, or decision to publish this manuscript. Other authors declared no conflict of interest. EDAT- 2026/08/18 23:36 MHDA- 2026/08/18 23:37 PMCR- 2026/08/18 CRDT- 2026/08/18 20:03 PHST- 2025/11/02 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/18 23:37 [medline] PHST- 2026/08/18 23:36 [pubmed] PHST- 2026/08/18 20:03 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 8764056 [pii] AID - dyag165 [pii] AID - 10.1093/ije/dyag165 [doi] PST - ppublish SO - Int J Epidemiol. 2026 Aug 18;55(5):dyag165. doi: 10.1093/ije/dyag165. PMID- 42612614 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260909 IS - 2352-3964 (Electronic) IS - 2352-3964 (Linking) VI - 131 DP - 2026 Sep TI - Trans-omics integration underscores distinct roles of polyunsaturated phospholipids in bidirectional offspring birth weight deviations. PG - 106435 LID - S2352-3964(26)00319-1 [pii] LID - 10.1016/j.ebiom.2026.106435 [doi] LID - 106435 AB - BACKGROUND: Abnormal birth weights are associated with adverse pregnancy outcomes and future metabolic consequences. We aimed to examine cord blood lipidomes from low, normal and high birth weight (LBW, NBW, HBW) infants to identify core lipid signatures associated with non-optimum birth weight, and to derive biological insights through trans-omics data integration with placental proteome, maternal plasma lipidome and clinical phenome. METHODS: We conducted quantitative lipidomics of cord blood samples from two independent cohorts: a retrospective discovery cohort (n = 147) and a prospective validation cohort (n = 73). Integration with placental proteomics, maternal plasma lipidomics and clinical phenomics was conducted to elucidate potential biological implications. FINDINGS: We identified substantial reductions in cord blood polyunsaturated phospholipids (PUFA-PLs) (FDR <0.05) associated with placental vesicle trafficking and formation in LBW, and altered neutrophil degranulation in HBW. Combinatorial analyses of paired maternal plasma and cord blood samples indicated that cord blood PUFA-PL reductions were not attributable to deficient maternal supply, but rather to impeded assimilation (LBW) and increased utilisation (HBW). INTERPRETATION: Our findings provide biological insights that may inform targetable, lipid-oriented nutritional and/or pharmacological strategies to modulate foetal growth and development, with the goal of optimising clinical outcomes for both mother and child. FUNDING: This work was supported by the National Natural Science Foundation of China (82170854, 81870579, 81870545, 82571043, 2357308); National High Level Hospital Clinical Research Funding (2022-PUMCH-C-019); Noncommunicable Chronic Diseases-National Science and Technology Major Project (2024ZD0530200 and 2024ZD0530204); Beijing Municipal Science & Technology Commission (Z201100005520011); Peking University Clinical Scientist Training Program (No. BMU2023PYJH022); Beijing Municipal Natural Science Foundation (7202163, 7184252). CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Zheng, Jia AU - Zheng J AD - Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Lam, Sin Man AU - Lam SM AD - Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies, Changzhou, 213022, China; Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, 510095, China. FAU - Florence Lim, Wei Ling AU - Florence Lim WL AD - Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies, Changzhou, 213022, China. FAU - Zhang, Shixuan AU - Zhang S AD - Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China. FAU - Mao, Lili AU - Mao L AD - Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Zhang, Qian AU - Zhang Q AD - Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Cui, Jingkang AU - Cui J AD - Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies, Changzhou, 213022, China. FAU - Zhang, Junqing AU - Zhang J AD - Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China. FAU - Gao, Ying AU - Gao Y AD - Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China. FAU - Zhao, Yurong AU - Zhao Y AD - Department of Obstetrics and Gynecology, Fuxing Hospital, Capital Medical University, Beijing, 100038, China. Electronic address: zhaoyurong72@163.com. FAU - Shui, Guanghou AU - Shui G AD - State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China; Guangzhou National Laboratory, Guangzhou, Guangdong, 510005, China. Electronic address: shui_guanghou@gzlab.ac.cn. FAU - Xiao, Xinhua AU - Xiao X AD - Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. Electronic address: xiaoxh2014@vip.163.com. LA - eng PT - Journal Article DEP - 20260818 PL - Netherlands TA - EBioMedicine JT - EBioMedicine JID - 101647039 RN - 0 (Phospholipids) RN - 0 (Fatty Acids, Unsaturated) RN - 0 (Proteome) SB - IM MH - Humans MH - Female MH - *Birth Weight MH - Pregnancy MH - *Phospholipids/blood/metabolism MH - Fetal Blood/metabolism MH - Infant, Newborn MH - *Lipidomics/methods MH - Multiomics MH - *Fatty Acids, Unsaturated/blood/metabolism MH - Placenta/metabolism MH - Proteomics/methods MH - Adult MH - Proteome PMC - PMC13505370 OTO - NOTNLM OT - Abnormal birth weight OT - Cord blood lipidomics OT - PUFAs OT - Placental proteomics COIS- Declaration of interests S.M.L., W.L.F.L and J.K.C are employees of LipidALL Technologies. The other authors declare no conflicting interests. EDAT- 2026/08/18 23:36 MHDA- 2026/09/09 23:36 PMCR- 2026/08/18 CRDT- 2026/08/18 18:11 PHST- 2025/10/22 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/09/09 23:36 [medline] PHST- 2026/08/18 23:36 [pubmed] PHST- 2026/08/18 18:11 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - S2352-3964(26)00319-1 [pii] AID - 106435 [pii] AID - 10.1016/j.ebiom.2026.106435 [doi] PST - ppublish SO - EBioMedicine. 2026 Sep;131:106435. doi: 10.1016/j.ebiom.2026.106435. Epub 2026 Aug 18. PMID- 42612460 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260926 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 204 DP - 2026 Nov TI - Functional liver imaging score and relative enhancement index predict transplant-free survival in cirrhosis. PG - 113162 LID - S0720-048X(26)00510-3 [pii] LID - 10.1016/j.ejrad.2026.113162 [doi] AB - OBJECTIVE: To evaluate the prognostic performance of the Relative Enhancement Index (REI) and the Functional Liver Imaging Score (FLIS), derived from gadoxetic acid-enhanced MRI, for predicting transplant-free survival in patients with cirrhosis; to determine whether these imaging biomarkers provide prognostic information after adjustment for clinical severity markers; to assess their interobserver agreement; and, because transplantation and death are competing events, to disentangle the association of FLIS and REI with each outcome using a competing-risks framework. METHODS: In this retrospective study, cirrhotic patients who underwent gadoxetic acid-enhanced MRI between September 2014 and August 2018 were included and followed for up to eight years for transplant-free survival. The cohort was assembled using stratified convenience sampling, with 20 patients selected from each Child-Pugh class (A, B, and C), to ensure representation across the full spectrum of liver dysfunction. Two independent readers assessed the Relative Enhancement Index (REI) and the Functional Liver Imaging Score (FLIS). Interobserver agreement was evaluated using kappa statistics for the individual FLIS components and ICC for the total FLIS score and REI. Transplant-free survival was analyzed using Kaplan-Meier curves, the log-rank test, and Cox proportional hazards regression. Multivariable Cox regression models were constructed separately for FLIS and REI, adjusted for age, MELD score, and Child-Pugh score. A sensitivity analysis was additionally performed by treating liver transplantation as a censoring event and all-cause death as the only event of interest. In addition, a competing-risks analysis was performed using cumulative incidence functions, Gray's test, and Fine-Gray subdistribution hazard models, with death and liver transplantation analysed alternately as the event of interest. Discrimination was compared with MELD and Child-Pugh score using DeLong's test, and incremental value was assessed by the change in Harrell's C-index with likelihood-ratio testing. The proportional hazards assumption was tested with Schoenfeld residuals, and a 30-day landmark analysis was performed. RESULTS: Sixty patients were included (32 men; median age, 58 years; interquartile range [IQR], 51-64 years), with 20 patients in each Child-Pugh class by design. During follow-up, 20 patients underwent liver transplantation (33.3 %), 16 died (26.7 %), and 24 remained alive without transplantation (40 %). Interobserver agreement was excellent for both FLIS (ICC = 0.97) and REI (ICC = 0.97). Because the cohort was deliberately stratified by Child-Pugh class, absolute transplant-free survival estimates were considered cohort-specific and not interpreted as population-level survival rates. AUROC values showed moderate discrimination for the composite endpoint of death or liver transplantation (FLIS, 0.745; REI, 0.703). In univariable Cox analysis, FLIS 0-3 and REI < 100 were significant predictors of adverse outcomes (death or liver transplantation), with hazard ratios of 3.767 (95 % CI: 1.872-7.579; p < 0.001) and 3.883 (95 % CI: 1.679-8.979; p = 0.002), respectively. After adjustment for age, MELD score, and Child-Pugh score, FLIS 0-3 remained independently associated with transplant-free survival (adjusted HR, 2.64; 95 % CI: 1.10-6.34; p = 0.030), whereas the association for REI < 100 was of similar magnitude but did not reach statistical significance (adjusted HR, 2.67; 95 % CI: 0.94-7.58; p = 0.065). In the death-only sensitivity analysis, FLIS remained significantly associated with survival (log-rank p = 0.042), whereas the association for REI was attenuated and did not reach statistical significance (log-rank p = 0.096). Discrimination did not differ significantly from that of MELD (AUROC, 0.731) or Child-Pugh score (AUROC, 0.753; all DeLong p >/= 0.43), and both indices improved model fit when added to MELD (likelihood-ratio p = 0.004 for both). In competing-risks analysis, FLIS 0-3 and REI < 100 were associated with the cumulative incidence of liver transplantation (subdistribution HR, 3.42 and 6.18, respectively) but not with that of death (1.41 and 1.45). CONCLUSION: FLIS and REI demonstrate excellent interobserver agreement and are associated with transplant-free survival in patients with cirrhosis, with moderate discriminative performance by AUROC analysis. FLIS remained independently associated with outcome after adjustment for age, MELD score, and Child-Pugh score, whereas REI showed an association of similar magnitude that did not reach significance after multivariable adjustment. Competing-risks analysis indicates that the association of both indices with the composite endpoint is driven predominantly by the transplantation component, and discrimination did not differ from that of MELD or Child-Pugh score. FLIS and REI should therefore be regarded as reproducible imaging markers of progression to end-stage liver disease rather than as validated predictors of mortality. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Melo Lima, Elissandra AU - Melo Lima E AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil. Electronic address: elissandra.lima@grupofleury.com.br. FAU - Eiras-Araujo, Antonio Luis AU - Eiras-Araujo AL AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil. Electronic address: antonio.eiras@rededor.com.br. FAU - Souza Rodrigues, Rosana AU - Souza Rodrigues R AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil. Electronic address: rosana.rodrigues@idor.org. FAU - Cerqueira Silva, Alexandre AU - Cerqueira Silva A AD - Surgery Department, Federal University of Rio de Janeiro, RJ, Brazil. Electronic address: acerqueira@ufrj.br. FAU - Ferreira da Motta Rezende, Guilherme AU - Ferreira da Motta Rezende G AD - Department of Hepatology, Federal University of Rio de Janeiro, RJ, Brazil. Electronic address: g.rezende@ufrj.br. FAU - Raggio Luiz, Ronir AU - Raggio Luiz R AD - Institute of Public Health, Federal University of Rio de Janeiro, RJ, Brazil. Electronic address: ronir@acd.ufrj.br. FAU - Mello Perez, Renata AU - Mello Perez R AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil. Electronic address: rmperez@hucff.ufrj.br. FAU - Braz Parente, Daniella AU - Braz Parente D AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil. Electronic address: dparente@hucff.ufrj.br. LA - eng PT - Journal Article DEP - 20260813 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 RN - K2I13DR72L (Gadolinium DTPA) RN - 0 (Contrast Media) RN - 0 (gadolinium ethoxybenzyl DTPA) SB - IM MH - Humans MH - *Liver Cirrhosis/diagnostic imaging/mortality/surgery MH - Female MH - Male MH - Gadolinium DTPA MH - Retrospective Studies MH - Contrast Media MH - *Magnetic Resonance Imaging/methods MH - *Liver Transplantation MH - Middle Aged MH - Prognosis MH - Liver/diagnostic imaging MH - Predictive Value of Tests OTO - NOTNLM OT - Biomarkers OT - Functional liver imaging score OT - Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid OT - Liver cirrhosis OT - Magnetic resonance imaging OT - Prognosis OT - Relative enhancement index OT - Survival analysis COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/18 23:36 MHDA- 2026/09/26 05:34 CRDT- 2026/08/18 18:06 PHST- 2026/04/02 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/08/18 23:36 [pubmed] PHST- 2026/08/18 18:06 [entrez] AID - S0720-048X(26)00510-3 [pii] AID - 10.1016/j.ejrad.2026.113162 [doi] PST - ppublish SO - Eur J Radiol. 2026 Nov;204:113162. doi: 10.1016/j.ejrad.2026.113162. Epub 2026 Aug 13. PMID- 42611885 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260820 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Development and validation of an intelligent weight verification management system for neonatal ready-to-use parenteral nutrition infusions. PG - e0351932 LID - 10.1371/journal.pone.0351932 [doi] LID - e0351932 AB - OBJECTIVE: To develop an intelligent weight verification management system for the quality of ready-to-use neonatal parenteral nutrition (PN) infusions and validate its reliability and application efficacy, aiming to enhance the quality and safety of these infusions. METHODS: An intelligent weight verification approach was established through drug density determination, maintenance of information parameters, automatic calculation of theoretical weight by the hospital information system (HIS), and actual measurement using a high-precision electronic scale. A total of 350 bags of neonatal PN orders prepared in the Pharmacy Intravenous Admixture Services (PIVAS) of our hospital from January to June 2024 were randomly selected. Seven compounding technicians prepared 50 bags each, and two designated pharmacists conducted verification using the residual liquid method and the weighing method, respectively. The error rate between the theoretical and actual weighing values was computed, statistical analysis of the pertinent data was conducted, and the viability of the weighing method was assessed from four perspectives: precision, trend controllability, operator stability, and verification efficiency. RESULTS: The relative standard deviation (RSD) of error rates was < 1%, indicating excellent precision. The average error rate was 1.92%, with 97.43% of error rates within the predefined threshold (-1% to 5%) and 90.9% within the 3sigma range. The error rate trends for different volumes aligned with variations in filling quantities, demonstrating controllable overall error trends. The interquartile range (IQR) variation in error rates among operators at different time points was < 30%, reflecting good operational stability. The weighing method achieved significantly higher verification efficiency (15.4 minutes per bag) than the residual liquid method (28.6 minutes per bag, P < 0.05) and identified an additional 6 unqualified infusions. CONCLUSION: The weight verification system demonstrates validated reliability in improving quality assurance and operational efficiency for ready-to-use neonatal PN infusions in PIVAS settings, warranting clinical implementation. CI - Copyright: (c) 2026 Tang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Tang, Xiaolin AU - Tang X AUID- ORCID: 0000-0003-0052-5168 AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Zhu, Chunhui AU - Zhu C AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Cheng, Dan AU - Cheng D AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Zhu, Jin AU - Zhu J AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Qiu, Lijuan AU - Qiu L AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Han, Xiaoxia AU - Han X AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Feng, Chuanhua AU - Feng C AD - Department of Pharmacy, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P.R.China. FAU - Chen, Mengying AU - Chen M AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260818 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Parenteral Nutrition Solutions) SB - IM MH - *Parenteral Nutrition/methods MH - Humans MH - Infant, Newborn MH - Reproducibility of Results MH - *Parenteral Nutrition Solutions PMC - PMC13484958 COIS- The authors declare that they have no conflict of interest. EDAT- 2026/08/18 17:37 MHDA- 2026/08/18 17:38 PMCR- 2026/08/18 CRDT- 2026/08/18 13:34 PHST- 2026/01/21 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/08/18 17:38 [medline] PHST- 2026/08/18 17:37 [pubmed] PHST- 2026/08/18 13:34 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - PONE-D-26-03553 [pii] AID - 10.1371/journal.pone.0351932 [doi] PST - epublish SO - PLoS One. 2026 Aug 18;21(8):e0351932. doi: 10.1371/journal.pone.0351932. eCollection 2026. PMID- 42609271 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260818 LR - 20260819 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutritional and behavioral determinants of overweight and obesity among school-aged children in Shandong Province, China: evidence from a large-scale cross-sectional study. PG - 1853192 LID - 10.3389/fnut.2026.1853192 [doi] LID - 1853192 AB - BACKGROUND: Childhood overweight and obesity are pressing global health challenges with rising prevalence in China. Shandong Province, as a populous and economically developed region, provides a critical context for understanding regional patterns and determinants. METHODS: A cross-sectional survey was conducted among 83,436 children aged 9-12 years from 155 schools in 16 cities (September-November 2025). Anthropometric measurements and validated questionnaires were used to assess weight status, demographics, family environment, and lifestyle factors. Overweight/obesity was classified using International Obesity Task Force (IOTF) cut-offs. Logistic regression identified associated risk and protective factors. RESULTS: The prevalence of overweight/obesity was 19.0%. Rates were higher in boys than girls (19.9% vs. 18.2%, p < 0.001) and increased with age (11-year-olds 20.4% vs. 9-year-olds 18.0%, p < 0.001). Urban children had slightly higher prevalence than rural peers (19.6% vs. 18.7%, p = 0.002). Factors independently associated with overweight/obesity included parental overweight/obesity (OR = 1.18, 95% CI: 1.10-1.26), maternal gestational diabetes (OR = 1.53, 95% CI: 1.36-1.71), and high birth weight (OR = 1.16, 95% CI: 1.09-1.24). Lifestyle behaviors were strongly associated: <1 h/day physical activity increased risk, while >1.5 h/day was protective (OR = 0.83, 95% CI: 0.79-0.87); >8 h sleep reduced risk (OR = 0.66, 95% CI: 0.60-0.72); >3 h/day screen time (OR = 1.10, 95% CI: 1.02-1.20) and >3 h/day homework (OR = 1.49, 95% CI: 1.38-1.62) elevated risk; frequent fruit/vegetable intake was protective, whereas fast-food consumption >3 times/week increased risk (OR = 1.12, 95% CI: 1.05-1.20). CONCLUSION: Childhood overweight/obesity in Shandong Province is influenced by demographic, familial, and lifestyle factors. Findings highlight the importance of multilevel interventions-targeting family health behaviors, maternal metabolic management, school-based physical activity promotion, and community nutrition policies-to curb the rising burden of obesity. CI - Copyright (c) 2026 Wang, Yan, Xu, Pang, Li, Chen and Ge. FAU - Wang, Wance AU - Wang W AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Yan, Lei AU - Yan L AD - School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China. FAU - Xu, Bowen AU - Xu B AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Pang, Xiangwei AU - Pang X AD - Jafron Biomedical Co., Ltd., Jinan, China. FAU - Li, Qianqian AU - Li Q AD - Shandong University of Art and Design, Jinan, China. FAU - Chen, Ke AU - Chen K AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Ge, Renkai AU - Ge R AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13477887 OTO - NOTNLM OT - Shandong Province OT - childhood obesity OT - lifestyle behaviors OT - overweight OT - risk factors COIS- XP was employed by Jafron Biomedical Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/03 CRDT- 2026/08/18 04:24 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 04:24 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.3389/fnut.2026.1853192 [doi] PST - epublish SO - Front Nutr. 2026 Aug 3;13:1853192. doi: 10.3389/fnut.2026.1853192. eCollection 2026. PMID- 42609262 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260819 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Predictors of childhood vaccination and recent influenza vaccination in older Brazilian adults: an analysis using conventional regression and machine learning approaches. PG - 1900872 LID - 10.3389/fpubh.2026.1900872 [doi] LID - 1900872 AB - BACKGROUND: Vaccination is an important public health intervention across the life course but its determinants may differ by life stage. We aimed to identify and compare predictors of childhood vaccination and recent influenza vaccination among older adults using conventional and machine learning approaches. METHODS: We used data from the second wave (2019-2021) of the Brazilian Longitudinal Study of Aging (ELSI-Brazil), a nationally representative cohort of individuals aged 50+. Analyses included 9,211 participants for childhood vaccination and 9,863 for influenza vaccination. Predictors were selected from sociodemographic, environmental, lifestyle, and health domains. Multivariable logistic regression and machine learning algorithms were used, with performance evaluated via area under the receiver operating characteristic curve (AUC). RESULTS: The best-performing machine learning model demonstrated acceptable performance for childhood vaccination (AUC = 0.72, 95% CI: 0.69-0.74) and recent influenza vaccination (AUC = 0.67, 95% CI: 0.64-0.70). For childhood vaccination, both analytical approaches identified age, sex, rural residence, parental education, school attendance at age 10, childhood access to books, and allergy as important predictors. Machine learning additionally identified age at school initiation, childhood economic status, self-rated childhood health, severe diarrhea, and history of childhood infectious diseases. Key predictors for recent influenza vaccination included age, marriage, educational level, employment, and hypertension/diabetes. Machine learning additionally highlighted the importance of vaccination history during childhood, life satisfaction, BMI, and mental health. CONCLUSION: Early-life socioeconomic and health conditions are important predictors of childhood immunization history, whereas current sociodemographic and health status are key predictors of recent vaccination. Machine learning identified supplementary predictors beyond traditional methods. CI - Copyright (c) 2026 Xu, Wang, Memon, Sun, Cheng and Long. FAU - Xu, Xianglong AU - Xu X AD - Department of Sexually Transmitted Disease, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Carlton, VIC, Australia. FAU - Wang, Biying AU - Wang B AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Memon, Kubra Maqsood AU - Memon KM AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Sun, Chen AU - Sun C AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Cheng, Yang AU - Cheng Y AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Long, Fuquan AU - Long F AD - Department of Sexually Transmitted Disease, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Influenza Vaccines) SB - IM MH - Humans MH - Brazil MH - Male MH - *Influenza Vaccines/administration & dosage MH - *Machine Learning MH - Female MH - *Vaccination/statistics & numerical data MH - *Influenza, Human/prevention & control MH - Aged MH - Longitudinal Studies MH - Middle Aged MH - Predictive Learning Models MH - Prediction Algorithms MH - Socioeconomic Factors PMC - PMC13477924 OTO - NOTNLM OT - childhood OT - influenza OT - machine learning OT - older adults OT - predictors OT - recent vaccination OT - vaccination COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/03 CRDT- 2026/08/18 04:23 PHST- 2026/06/05 00:00 [received] PHST- 2026/07/05 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 04:23 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1900872 [doi] PST - epublish SO - Front Public Health. 2026 Aug 3;14:1900872. doi: 10.3389/fpubh.2026.1900872. eCollection 2026. PMID- 42609256 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260828 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Molecular sensitization profiles and beta-parvalbumin sensitization burden associated with clinical fish allergy in children. PG - 1918831 LID - 10.3389/fimmu.2026.1918831 [doi] LID - 1918831 AB - BACKGROUND: Fish allergy is a potentially severe condition that is frequently managed with broad elimination diets. Molecular allergology may improve risk stratification by distinguishing clinically relevant fish allergy from asymptomatic sensitization. We aimed to characterize molecular sensitization patterns in fish-sensitized children and identify molecular profiles associated with clinical fish allergy. METHODS: Sixty-one fish-sensitized children (0-18 years) were evaluated using a multiplex molecular allergy assay (ALEX2). Twenty-eight children were classified as fish-allergic based on a positive oral food challenge (OFC) or consistent clinical reactions, whereas 33 sensitized children were clinically tolerant. Molecular sensitization patterns were analyzed using Bayesian logistic model averaging (BMA), Firth penalized logistic regression, receiver operating characteristic (ROC) analysis, and hierarchical clustering. RESULTS: Sensitization to beta-parvalbumins was significantly more frequent in allergic than tolerant children. Allergic children also exhibited a substantially higher cumulative beta-parvalbumin sensitization burden (median 7 [IQR 5-7] vs 3 [IQR 1-5]; p<0.001). BMA prioritized Clu h 1, Gad m 2_3, and Cyp c 1 as the molecular allergens most strongly associated with clinical fish allergy. Sensitization to Gad m 2_3 was observed exclusively among allergic children. An exploratory parsimonious model incorporating cumulative beta-parvalbumin sensitization burden together with Gad m 2_3 achieved an optimism-corrected AUC of 0.867. CONCLUSIONS: Molecular sensitization profiles, particularly the cumulative burden of beta-parvalbumin sensitization, were associated with clinical fish allergy in children. Clu h 1 and Cyp c 1 emerged as the molecular markers most consistently associated with clinical reactivity, whereas Gad m 2_3 was observed only among allergic children in this cohort and may represent a low-prevalence exploratory finding. These findings suggest a potential role for molecular allergen profiling in risk stratification among fish-sensitized children but require validation in larger independent cohorts before clinical application. CI - Copyright (c) 2026 Dal, Heydarova and Sekerel. FAU - Dal, Sevda Tuten AU - Dal ST AD - Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkiye. FAU - Heydarova, Lala AU - Heydarova L AD - Department of Pediatrics, Azerbaijan State Advanced Training Institute for Doctors named after Aziz Aliyev, Baku, Azerbaijan. FAU - Sekerel, Bulent Enis AU - Sekerel BE AD - Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Allergens) RN - 0 (Parvalbumins) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - *Food Hypersensitivity/immunology/diagnosis MH - Child MH - Child, Preschool MH - Male MH - Female MH - Infant MH - *Allergens/immunology MH - Animals MH - Adolescent MH - *Fishes/immunology MH - *Parvalbumins/immunology MH - Immunoglobulin E/immunology/blood MH - Infant, Newborn MH - Immunization PMC - PMC13477939 OTO - NOTNLM OT - fish allergy OT - molecular allergology OT - pediatric allergy OT - sensitization burden OT - beta-parvalbumin COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/03 CRDT- 2026/08/18 04:22 PHST- 2026/06/24 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 04:22 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1918831 [doi] PST - epublish SO - Front Immunol. 2026 Aug 3;17:1918831. doi: 10.3389/fimmu.2026.1918831. eCollection 2026. PMID- 42609231 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260818 LR - 20260819 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Intervention methods and influencing factors of vitamin D deficiency in Northeast China: a self-controlled trial and randomized controlled trial study. PG - 1778526 LID - 10.3389/fnut.2026.1778526 [doi] LID - 1778526 AB - BACKGROUND: Vitamin D deficiency is common among children in high-latitude regions. However, region-specific intervention strategies remain unclear. Few studies have simultaneously examined outdoor activity intervention, vitamin D supplementation, and genetic polymorphisms. Thus, this study aimed to explore feasible intervention strategies for children in Northeast China. METHOD: Sixty-one children were asked to increase outdoor activities for 8 weeks (June-August). Outdoor activity duration and ultraviolet (UV) intensity were recorded. Changes in serum 25(OH)D(3) levels and the association with UV exposure were analyzed. Separately, 289 children were randomized to receive 0, 400, or 800 IU/d vitamin D for 8 weeks. The dose-response relationship between vitamin D intake and serum 25(OH)D(3) was analyzed. Effects of CYP2R1 single nucleotide polymorphisms (SNPs) (rs1562902, rs10741657) on supplementation response were also evaluated. RESULTS: Outdoor activity duration increased by 11 min/d, and estimated vitamin D production from UV increased by 60.73 IU/d, but serum 25(OH)D(3) did not change significantly (18.52 +/- 4.07 vs. 18.25 +/- 3.11 ng/ml); this change was not associated with outdoor time, UV intensity, or calculated vitamin D production from UV. In the supplementation trial, serum 25(OH)D(3) increased by 8.82 +/- 7.53 ng/ml in the 400 IU/d group and 15.06 +/- 9.40 ng/ml in the 800 IU/d group. Total vitamin D intake (diet + supplement) was estimated to require at least 733.21 IU/d to achieve serum 25(OH)D(3) >/=30 ng/ml. Children with CT/TT genotypes (rs1562902) and AG/GG genotypes (rs10741657) showed a trend of lower sensitivity to supplementation. CONCLUSION: Increasing outdoor activity did not improve vitamin D status in children in Northeast China, but daily supplementation was effective. Dietary vitamin D intake and SNPs should be considered when formulating individualized supplementation doses. CI - Copyright (c) 2026 Liu, Qu, Jin, Jia and Na. FAU - Liu, Junyi AU - Liu J AD - Department of Clinical Nutrition, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China. AD - Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China. FAU - Qu, Chenyin AU - Qu C AD - College of Public Health, Shanghai University of Medicine and Health Sciences, Shanghai, China. FAU - Jin, Shanshan AU - Jin S AD - Department of Nutrition, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. AD - Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China. FAU - Jia, Yubing AU - Jia Y AD - Department of Clinical Nutrition, Chongqing Hospital of Jiangsu Province Hospital, Chongqing, China. AD - Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China. FAU - Na, Lixin AU - Na L AD - College of Public Health, Shanghai University of Medicine and Health Sciences, Shanghai, China. AD - Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13477899 OTO - NOTNLM OT - children OT - single nucleotide polymorphisms OT - ultraviolet irradiation OT - vitamin D deficiency OT - vitamin D supplementation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/03 CRDT- 2026/08/18 04:20 PHST- 2025/12/31 00:00 [received] PHST- 2026/06/17 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 04:20 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.3389/fnut.2026.1778526 [doi] PST - epublish SO - Front Nutr. 2026 Aug 3;13:1778526. doi: 10.3389/fnut.2026.1778526. eCollection 2026. PMID- 42608744 OWN - NLM STAT- Publisher LR - 20260818 IS - 1537-7385 (Electronic) IS - 0894-9115 (Linking) DP - 2026 Aug 18 TI - Association Between Vitamin D and Muscle Mass and Function in Children and Adolescents: A Study Based on National Health and Nutrition Examination Survey (NHANES). LID - 10.1097/PHM.0000000000003130 [doi] AB - OBJECTIVE: This study aimed to investigate the association between vitamin D and muscle health in children and adolescents. DESIGN: A cross-sectional analysis was performed using data from 2,775 participants aged 8-17 years in NHANES 2011-2014. Muscle mass was evaluated through whole-body and regional muscle-to-fat ratios (MFRs), while muscle function was assessed using relative handgrip strength (RHGS). Vitamin D status was characterized by serum 25-hydroxyvitamin D (25(OH)D), 25(OH)D3, 25(OH)D2 levels, and 25(OH)D categorized as deficient, insufficient, or sufficient. The analysis employed covariate-adjusted linear regression and restricted cubic splines (RCS), with predictive ability of RHGS assessed via receiver operating characteristic (ROC) analysis. RESULTS: Significant positive associations between total 25(OH)D levels and muscle-related parameters were observed across adjusted models. Associations varied across sex and age groups, and RHGS demonstrated limited predictive value for vitamin D status across all subgroups (maximum AUC = 0.635). CONCLUSIONS: Total 25(OH)D appeared to be the most informative indicator of vitamin D status in relation to pediatric muscle health, although associations varied to sex, age, and assessment measures. RHGS demonstrated limited utility as a screening indicator for vitamin D insufficiency or deficiency status. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Tian, Feng AU - Tian F AD - Department of Pediatric Surgery, Suzhou Wujiang District Children's Hospital, Suzhou, China. FAU - Xu, Lina AU - Xu L AD - Department of Respiratory Medicine, Children's Hospital of Soochow University, China. FAU - Huang, Wei AU - Huang W AD - Department of Pediatrics, Friendship Hospital of Ily Kazak Autonomous Prefecture, China. FAU - Jiang, Dapeng AU - Jiang D AD - Department of Oncology (Ward 2), Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200100, People's Republic of China. FAU - Dai, Yinfang AU - Dai Y AD - Department of Respiratory Medicine, Children's Hospital of Soochow University, China. LA - eng PT - Journal Article DEP - 20260818 PL - United States TA - Am J Phys Med Rehabil JT - American journal of physical medicine & rehabilitation JID - 8803677 SB - IM OTO - NOTNLM OT - Children and Adolescents OT - Muscle-to-fat Ratios OT - NHANES OT - Relative Handgrip Strength OT - Vitamin D COIS- Conflict of Interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:46 CRDT- 2026/08/18 00:32 PHST- 2025/06/27 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/18 07:46 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 00:32 [entrez] AID - 00002060-990000000-01055 [pii] AID - 10.1097/PHM.0000000000003130 [doi] PST - aheadofprint SO - Am J Phys Med Rehabil. 2026 Aug 18. doi: 10.1097/PHM.0000000000003130. PMID- 42608724 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260818 LR - 20260820 IS - 2524-4434 (Electronic) IS - 2096-9384 (Print) IS - 2524-4434 (Linking) VI - 8 IP - 1 DP - 2026 Aug 18 TI - Clinical and neurophysiology study of 17 children with epileptic negative myoclonus. LID - 10.1186/s42494-026-00273-3 [doi] LID - 31 AB - BACKGROUND: Epileptic negative myoclonus (ENM) is a clinically underrecognized seizure type, and systematic data on its clinical manifestations and optimal management strategies in pediatric populations remain scarce. This case series aimed to describe the clinical manifestations, neurophysiological patterns, and therapeutic outcomes in pediatric ENM. METHODS: A retrospective descriptive analysis was conducted on 17 ENM patients diagnosed at Wuxi Children's Hospital between October 2017 and June 2024. Clinical data, electroencephalogram (EEG) findings, and treatment responses were systematically evaluated. RESULTS: The cohort showed a marked female predominance (female-to-male ratio of 12:5). All cases exhibited upper-limb ENM, with contralateral central-parietal epileptiform discharges observed in ictal EEG. Two patients presented additional lower-limb ENM accompanied by midline discharges. Clinically, ENM manifested as the initial symptom in five cases (29.4%), including two with isolated ENM. Therapeutic outcomes varied: among four non-electrical status epilepticus during sleep (ESES) patients, antiseizure medications (ASMs) achieved symptom control, including one case of oxcarbazepine (OXC)-associated ENM that resolved after transition to valproate (VPA). Of 13 ESES-positive patients, three responded to ASMs alone, while nine received methylprednisolone pulse therapy (MPT), and one surgical candidate with focal cortical dysplasia (FCD) type IIa achieved post-resection remission. Among the nine children treated with MPT: four showed a good response; four relapsed upon steroid withdrawal; and one responded well to ketogenic diet (KD) therapy. CONCLUSIONS: ENM can manifest as the initial or sole epilepsy symptom in children. The marked female predominance in this cohort suggests that sex-related factors may play an important role in the expression or underlying mechanisms of ENM. Additionally, a correlation was found between the EEG discharge patterns and the specific limb regions involved. Regarding treatment, OXC may exacerbate ENM, necessitating cautious use. Steroid therapy should be considered for ESES cases unresponsive to ASMs. Refractory ENM with ESES warrants evaluation for structural abnormalities, particularly cortical dysplasia. Early EEG and neuroimaging improve diagnostic accuracy, while combined therapies-ASMs, immunomodulation, KD, or surgery-optimize outcomes. These findings highlight ENM's diagnostic intricacy and the need for individualized management. CLINICAL TRIAL REGISTRATION: Not applicable. CI - (c) 2026. The Author(s). FAU - Zhang, Lin AU - Zhang L AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Xu, Tao AU - Xu T AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Jing, Miao AU - Jing M AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Ma, Jingbo AU - Ma J AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Sun, Mingxia AU - Sun M AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Hua, Ying AU - Hua Y AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. tomato331316@163.com. FAU - Tang, Hongwei AU - Tang H AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. Tangliu229@126.com. FAU - Wang, Yanping AU - Wang Y AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. ypwang591@aliyun.com. LA - eng PT - Journal Article DEP - 20260818 PL - England TA - Acta Epileptol JT - Acta epileptologica JID - 9918591884406676 PMC - PMC13483403 OTO - NOTNLM OT - Clinical characteristics OT - ENM OT - ESES OT - FCD OT - MPT COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Wuxi Children's Hospital affiliated to Jiangnan University, and parental consent was obtained (Approval number: WXCH2024-05-086). Declaration of AI use: The authors acknowledge the use of DeepSeek-V3 (accessed March 2026) to support English language polishing and the reorganization of Discussion section for clarity and flow. The specific prompts used included: "Please help me polish this paragraph" and "Please help me restructure the logic of this discussion section." Competing interests: The authors declare no competing interests. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/18 CRDT- 2026/08/18 00:31 PHST- 2025/10/11 00:00 [received] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 00:31 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.1186/s42494-026-00273-3 [pii] AID - 273 [pii] AID - 10.1186/s42494-026-00273-3 [doi] PST - epublish SO - Acta Epileptol. 2026 Aug 18;8(1):31. doi: 10.1186/s42494-026-00273-3. PMID- 42608346 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260824 IS - 1600-0838 (Electronic) IS - 0905-7188 (Print) IS - 0905-7188 (Linking) VI - 36 IP - 8 DP - 2026 Aug TI - Growth and Maturation Assessment in Youth Sport: Balancing Benefits and Risks. PG - e70361 LID - 10.1111/sms.70361 [doi] LID - e70361 AB - The assessment and monitoring of growth and maturation (G&M) in youth sport has become increasingly debated, with some medical advisory boards expressing concerns that weighing young athletes may contribute to body image disturbances and eating disorders. In some instances, these concerns have prompted recommendations against anthropometric assessment in youth sport. This narrative review examines the evidence for and against G&M assessment in youth sport, evaluating the benefits of appropriately implemented assessment against the potential risks. G&M assessment supports injury prevention by identifying athletes undergoing rapid growth who are at increased risk of growth-related and overuse injuries. It enables individualized training by aligning programing with biological rather than chronological age, and promotes inclusive talent identification by counteracting maturity-related selection biases that systematically exclude late-maturing athletes. While concerns about body image and eating disorders are valid, the reviewed evidence suggests that the risks are not associated with the collection of anthropometric measurements itself, but rather with how information is communicated and the broader sociocultural and coaching environments in which athletes train. Five G&M implementation principles are proposed to maximize benefits and minimize risks: stakeholder education, privacy protection, voluntary participation, assessment by trained professionals, and integration within a holistic and child-centered athlete monitoring system. Based on the evidence reviewed, G&M assessment conducted within appropriate ethical and professional frameworks can support athlete welfare, development, and equitable participation. CI - (c) 2026 The Author(s). Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd. FAU - Lundberg, Tommy R AU - Lundberg TR AUID- ORCID: 0000-0002-6818-6230 AD - Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. AD - Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden. FAU - Parry, Gemma N AU - Parry GN AUID- ORCID: 0000-0002-1915-9324 AD - Department for Health, University of Bath, Bath, UK. FAU - Cumming, Sean P AU - Cumming SP AUID- ORCID: 0000-0003-1705-9642 AD - Department for Health, University of Bath, Bath, UK. LA - eng PT - Journal Article PT - Review PL - Denmark TA - Scand J Med Sci Sports JT - Scandinavian journal of medicine & science in sports JID - 9111504 SB - IM MH - Humans MH - *Youth Sports MH - Athletic Injuries/prevention & control MH - Adolescent MH - Cumulative Trauma Disorders/prevention & control MH - Anthropometry MH - Child MH - Body Image MH - Risk Assessment MH - *Adolescent Development PMC - PMC13481284 OTO - NOTNLM OT - athlete development OT - body weight OT - injury risk OT - maturity OT - talent identification OT - team sports COIS- The authors declare no conflicts of interest. EDAT- 2026/08/17 23:39 MHDA- 2026/08/17 23:40 PMCR- 2026/08/18 CRDT- 2026/08/17 22:23 PHST- 2026/07/08 00:00 [revised] PHST- 2026/05/18 00:00 [received] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/08/17 23:40 [medline] PHST- 2026/08/17 23:39 [pubmed] PHST- 2026/08/17 22:23 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - SMS70361 [pii] AID - 10.1111/sms.70361 [doi] PST - ppublish SO - Scand J Med Sci Sports. 2026 Aug;36(8):e70361. doi: 10.1111/sms.70361. PMID- 42608021 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260825 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 96 IP - 9 DP - 2026 Sep TI - A Therapeutic Greenhouse Model for School-Based Health. PG - e70218 LID - 10.1111/josh.70218 [doi] LID - e70218 AB - BACKGROUND: The Therapeutic Greenhouse Program, located at an elementary school in an underserved community, offers a sustainable and reproducible model for school-based garden programming. Developed by a school-based health center, the program integrates medical and behavioral health services within an alternative therapeutic environment. It has been maintained since 2020 through strong partnerships with school staff, families, and community organizations. CONTRIBUTIONS TO PRACTICE: The program bridges hands-on food literacy education with clinical care delivery. Elementary school children engage in structured sessions that combine nutrition education, experiential learning, and behavioral health support within the garden setting. Close collaboration with teachers and community partners embeds the program into the daily school routine, fostering a multidisciplinary approach to student wellness. IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: This model supports policies that expand school-based health services into nontraditional care environments. It demonstrates the feasibility of interdisciplinary collaboration in delivering integrated, experiential health education. Furthermore, the program advances health equity by providing inclusive, nonstigmatizing access to health promotion and fresh food. CONCLUSIONS: By leveraging billable services, strategic partnerships, volunteer engagement, and small-scale revenue generation, the program provides a financially sustainable and replicable framework for integrating healthcare and education in school settings. CI - (c) 2026 American School Health Association. FAU - Casbarro, Nicole AU - Casbarro N AUID- ORCID: 0009-0004-6168-0246 AD - Community Health Center, Inc, Middletown, Connecticut, USA. AD - Quinnipiac University, Hamden, Connecticut, USA. FAU - Violano, Pina M AU - Violano PM AUID- ORCID: 0009-0004-4608-5529 AD - Quinnipiac University, Hamden, Connecticut, USA. LA - eng PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - *School Health Services/organization & administration MH - Child MH - *Health Promotion/organization & administration/methods MH - *Health Education/organization & administration MH - *Gardening MH - Schools PMC - PMC13481118 OTO - NOTNLM OT - food literacy OT - school garden program OT - school health OT - school-based health center OT - therapeutic greenhouse COIS- The authors declare no conflicts of interest. EDAT- 2026/08/17 23:39 MHDA- 2026/08/17 23:40 PMCR- 2026/08/17 CRDT- 2026/08/17 19:43 PHST- 2026/07/06 00:00 [revised] PHST- 2025/09/07 00:00 [received] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/17 23:40 [medline] PHST- 2026/08/17 23:39 [pubmed] PHST- 2026/08/17 19:43 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - JOSH70218 [pii] AID - 10.1111/josh.70218 [doi] PST - ppublish SO - J Sch Health. 2026 Sep;96(9):e70218. doi: 10.1111/josh.70218. PMID- 42607051 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260902 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - The COCCOS study: A protocol for a multicentric quasi-experimental study of a healthcare transition program for young people with chronic conditions. PG - e0353932 LID - 10.1371/journal.pone.0353932 [doi] LID - e0353932 AB - INTRODUCTION: The growing number of adolescents and young adults (AYAs) living with chronic conditions highlights the need for effective healthcare transition programmes (TPs) to support the transfer from paediatric to adult care. Despite existing recommendations, many AYAs experience inadequate preparation, resulting in disrupted care and adverse health outcomes. The COCCOS project developed a co-designed TP to address these challenges. This study presents the protocol for an evaluation of this programme. METHODS AND ANALYSIS: A multicentric quasi-experimental pretest-posttest study will be conducted in two Belgian university hospitals. AYAs aged 17-18 years with type 1 diabetes, asthma, or obesity will be recruited into an intervention group receiving the COCCOS TP or a control group receiving usual care. The intervention consists of four structured consultations over 13-16 months, focusing on transition preparation, autonomy, and continuity of care. Primary outcome is transition readiness, measured using the Transition Readiness Assessment Questionnaire. Secondary outcomes include patient empowerment, medication adherence, health-related quality of life, and mental health. Data will be collected at baseline, transfer, and four months post-transfer. Cost-effectiveness will be assessed from a healthcare payer perspective using quality-adjusted life years. A mixed-methods process evaluation will examine implementation fidelity, acceptability, and contextual factors through observations, surveys, and interviews. The study is registered on ClinicalTrials.gov under identifier NCT07145671. DISCUSSION AND CONCLUSION: This study will provide comprehensive evidence on the feasibility, preliminary effectiveness, cost-effectiveness, and implementation of a co-designed TP in real-world clinical practice. By integrating clinical, economic, and process outcomes, it addresses key gaps in transitional care research. Findings will inform refinement of the programme and the design of a future large-scale trial, contributing to the development of sustainable, patient-centred transition care for AYAs with chronic conditions. CI - Copyright: (c) 2026 Van Wilder et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Van Wilder, Lisa AU - Van Wilder L AUID- ORCID: 0000-0003-4394-2623 AD - Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. FAU - Janssens, Natwarin AU - Janssens N AUID- ORCID: 0000-0002-4821-5444 AD - Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. AD - Department of Nursing and Midwifery, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. FAU - Van Hoorenbeeck, Kim AU - Van Hoorenbeeck K AUID- ORCID: 0000-0002-8812-4440 AD - Department of Pediatrics, Antwerp University Hospital, Antwerp, Belgium. AD - Laboratory of Experimental Medicine and Pediatrics (LEMP), University of Antwerp, Antwerp, Belgium. FAU - Vanden Wyngaert, Karsten AU - Vanden Wyngaert K AD - Ghent University Hospital, Ghent, Belgium. FAU - Goossens, Eva AU - Goossens E AD - Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. AD - Department of Patient Care, Antwerp University Hospital, Antwerp, Belgium. FAU - De Smedt, Delphine AU - De Smedt D AD - Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. LA - eng SI - ClinicalTrials.gov/NCT07145671 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260817 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Young Adult MH - Asthma/therapy MH - Belgium MH - Chronic Disease/therapy MH - Cost-Benefit Analysis MH - Diabetes Mellitus, Type 1/therapy MH - Obesity/therapy MH - Quality of Life MH - *Transition to Adult Care MH - Non-Randomized Controlled Trials as Topic MH - Multicenter Studies as Topic PMC - PMC13480643 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/17 17:45 MHDA- 2026/08/17 17:46 PMCR- 2026/08/17 CRDT- 2026/08/17 13:33 PHST- 2026/06/16 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/17 17:46 [medline] PHST- 2026/08/17 17:45 [pubmed] PHST- 2026/08/17 13:33 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - PONE-D-26-23316 [pii] AID - 10.1371/journal.pone.0353932 [doi] PST - epublish SO - PLoS One. 2026 Aug 17;21(8):e0353932. doi: 10.1371/journal.pone.0353932. eCollection 2026. PMID- 42606853 OWN - NLM STAT- Publisher LR - 20260820 IS - 1939-0602 (Electronic) IS - 1091-7527 (Linking) DP - 2026 Aug 17 TI - Exploring family, health system, and health professional dynamics related to implementation of a five-component framework for weight and lifestyle conversations with children and families. LID - 10.1037/fsh0001062 [doi] AB - INTRODUCTION: Brief intervention frameworks can support health professionals to motivate patients to adopt lifestyle changes. In New South Wales, Australia, health services use the 5As (ask, assess, advise, assist, and arrange) framework to address unhealthy lifestyles and overweight and obesity in children. This study assessed health professionals' adherence to the 5As framework and factors influencing families' perceptions and propensity to adopt lifestyle changes. METHODS: This observational, cross-sectional study analyzed data from electronic medical records and caregiver surveys from a regional health service in New South Wales, Australia, over 12 months from June 2022 to May 2023. RESULTS: Of n = 461 caregivers who completed valid surveys, 64.9% reported their child received a growth assessment, but only 6.3% received the full 5As framework. Children under 4 years, those attending a community health service, and those with a healthy weight were most likely to receive the complete 5As framework. In contrast, children over 13 years, those attending an emergency department and those with obesity were least likely. Reported adherence with the 5As framework influenced caregivers' perceptions and reported intervention impact. DISCUSSION: Children routinely received growth assessments, but many families did not receive subsequent steps of the 5As framework. Improving health professional adherence to the framework is necessary for promoting behavior change. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Schwartzkoff, Emma AU - Schwartzkoff E AUID- ORCID: 0000-0002-0486-9251 AD - School of Health Sciences (Nutrition and Dietetics), University of Newcastle. FAU - Duncanson, Kerith AU - Duncanson K AD - School of Medicine and Public Health, University of Newcastle. FAU - Bailey, Andrew AU - Bailey A AD - Port Macquarie Community Health, Mid North Coast Local Health District. FAU - Williams, Georgina AU - Williams G AD - School of Medicine and Public Health, University of Newcastle. FAU - Burrows, Tracy AU - Burrows T AD - School of Health Sciences (Nutrition and Dietetics), University of Newcastle. LA - eng GR - National Health and Medical Research Council/ PT - Journal Article DEP - 20260817 PL - United States TA - Fam Syst Health JT - Families, systems & health : the journal of collaborative family healthcare JID - 9610836 SB - IM EDAT- 2026/08/17 17:45 MHDA- 2026/08/17 17:45 CRDT- 2026/08/17 11:35 PHST- 2026/08/17 17:45 [pubmed] PHST- 2026/08/17 17:45 [medline] PHST- 2026/08/17 11:35 [entrez] AID - 2028-14294-001 [pii] AID - 10.1037/fsh0001062 [doi] PST - aheadofprint SO - Fam Syst Health. 2026 Aug 17. doi: 10.1037/fsh0001062. PMID- 42606737 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20261008 IS - 1437-9813 (Electronic) IS - 0179-0358 (Linking) VI - 42 IP - 1 DP - 2026 Aug 17 TI - Challenging the size: ovarian-sparing surgery in borderline huge pediatric ovarian tumors. LID - 344 [pii] LID - 10.1007/s00383-026-06582-5 [doi] AB - OBJECTIVE: Huge ovarian tumors in paediatric patients pose a surgical challenge, particularly in distinguishing tumor margins from ovarian parenchyma. While ovarian preservation is recommended for benign masses, concerns about tumor size may limit its application. This study evaluates the feasibility and outcomes of ovarian-sparing surgery (OSS) in children with giant ovarian tumors. MATERIALS AND METHODS: A retrospective study was realize on girls (< 18 years) who underwent surgery for ovarian masses with cystic lesions >/= 8 cm in our department (2009-2019). We included all patients classified O-RADS 3 and 4, and excluded O-RADS 5 in those OSS is contraindicated. Data on clinical presentation, imaging, tumor characteristics, surgical approach, histopathology, and follow-up were collected. Patients were categorized into two groups: OSS and oophorectomy (OV). RESULTS: Thirty patients (mean age: 13 years, range 3-17) were treated, including one with bilateral tumors. Palpable abdominal mass was the most common symptom (33.3%). The median tumor diameter was 148 mm (range 80-350 mm); 16 were purely cystic, 15 had mixed components, and 4 had calcifications. Tumor markers were negative except in 2 cases. Histology confirmed all tumors were benign (17 teratomas, 12 cystadenomas, 2 functional cysts). CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Mariani, Aurora AU - Mariani A AUID- ORCID: 0000-0001-6346-1259 AD - Department of Pediatric Surgery, Angers University Hospital, Angers, France. auroramariani@hotmail.it. AD - Department of Pediatric Surgery, Centre Hospitalo Universitaire, 4 rue Larrey, 49000, Angers, France. auroramariani@hotmail.it. FAU - Fiorenza, Venusia AU - Fiorenza V AD - Department of Pediatric Surgery, Gaslini Children Hospital, Genova, Italy. FAU - Hameury, Frederic AU - Hameury F AD - Department of Pediatric Surgery, Hopital Femme Mere Enfant, Bron, France. FAU - Goulin, Jeanne AU - Goulin J AD - Department of Pediatric Surgery, Hopital Femme Mere Enfant, Bron, France. FAU - Dijoud, Frederique AU - Dijoud F AD - Department of Pathology, Hopital Femme Mere Enfant, Bron, France. FAU - Gorduza, Daniela AU - Gorduza D AD - Department of Pediatric Surgery, St Etienne University Hospital, St Etienne, France. LA - eng PT - Journal Article DEP - 20260817 PL - Germany TA - Pediatr Surg Int JT - Pediatric surgery international JID - 8609169 SB - IM MH - Humans MH - Female MH - *Ovarian Neoplasms/surgery/pathology MH - Retrospective Studies MH - Child MH - Adolescent MH - *Organ Sparing Treatments/methods MH - Child, Preschool MH - *Ovariectomy/methods MH - Feasibility Studies MH - Tumor Burden MH - Ovary/surgery OTO - NOTNLM OT - Adolescent gynaecology OT - Fertility issues. OT - Ovarian sparing surgery OT - Ovarian tumor COIS- Declarations. Conflict of interest: The authors have no conflicts of interest relevant to this article. EDAT- 2026/08/17 17:45 MHDA- 2026/08/17 17:46 CRDT- 2026/08/17 11:15 PHST- 2026/05/19 00:00 [received] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/17 17:46 [medline] PHST- 2026/08/17 17:45 [pubmed] PHST- 2026/08/17 11:15 [entrez] AID - 10.1007/s00383-026-06582-5 [pii] AID - 10.1007/s00383-026-06582-5 [doi] PST - epublish SO - Pediatr Surg Int. 2026 Aug 17;42(1):344. doi: 10.1007/s00383-026-06582-5. PMID- 42606340 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260921 IS - 1939-327X (Electronic) IS - 0012-1797 (Linking) VI - 75 IP - 10 DP - 2026 Oct 1 TI - Body Composition-Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation. PG - 1810-1822 LID - 10.2337/db26-0136 [doi] AB - Traditional measures such as BMI do not fully capture obesity-related metabolic risks. Here, we examined DXA-derived body composition patterns in children (n = 11,238) using the discriminative dimensionality reduction tree algorithm, which was validated in an independent cohort (n = 2,001). The tree structure revealed a continuous landscape of body composition phenotypes, with distinct spatial gradients for fat and lean mass. Within the phenotypic tree, fat-dominant phenotypes clustered in the region of low dimension 1 and low dimension 2 (corresponding to the lower left branches), where they demonstrated significant spatial overlap with high-risk clusters for hypertension, elevated LDL cholesterol (LDL-C), total cholesterol, and triglycerides (TG) (Moran I >0.3, all P < 0.001). Meanwhile, phenotypes characterized by elevated lean mass coupled with increased adiposity were localized in the region of low dimension 1 and high dimension 2 (upper left branches), demonstrating an increased risk of low HDL-C and high TG (Moran I >0.6, all P < 0.001). In contrast, lean-dominant phenotypes clustered in the region of high dimension 1 and high dimension 2 (upper right branches), which were associated with a relatively low risk of hyperglycemia, insulin resistance, and high LDL-C (Moran I >0.1, all P < 0.001). For practical utility, we developed a publicly available web application to map individual data on the reference tree architecture, allowing for assessment of cardiometabolic risk. Our findings highlight the value of more precise body composition measures for early identification and prevention of obesity-related health problems. ARTICLE HIGHLIGHTS: Childhood obesity shows large differences in body composition and health risk that are not well captured by BMI or simple metabolic classifications, prompting the need for more precise characterization. This study aimed to determine whether a data-driven framework integrating detailed body composition measures could better describe obesity-related phenotypic heterogeneity and its relationship with cardiometabolic risk in children. We delineated a continuous body composition manifold encompassing fat-dominant, lean-dominant, and concomitant high-mass phenotypes, which captured diverging cardiometabolic risk trajectories and yielded modest incremental improvements in risk prediction. These findings support more precise risk stratification and provide a practical tool to improve early identification and prevention of obesity-related health complications in children. CI - (c) 2026 by the American Diabetes Association. FAU - Xiao, Pei AU - Xiao P AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Cheng, Hong AU - Cheng H AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Xiong, Jingfan AU - Xiong J AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Yan, Yinkun AU - Yan Y AUID- ORCID: 0000-0002-7758-744X AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Liu, Junting AU - Liu J AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University and Capital Institute of Pediatrics, Beijing, China. FAU - Liu, Li AU - Liu L AD - School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China. FAU - Dong, Hongbo AU - Dong H AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Li, Yan AU - Li Y AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Ye, Peiyu AU - Ye P AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Fu, Liwan AU - Fu L AUID- ORCID: 0000-0002-7851-6379 AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Gao, Liwang AU - Gao L AD - School of Public Health, Capital Medical University, Beijing, China. FAU - Chen, Fangfang AU - Chen F AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Shan, Xinying AU - Shan X AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Lan, Lina AU - Lan L AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Li, Yanyan AU - Li Y AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Mi, Jie AU - Mi J AUID- ORCID: 0000-0003-0630-8447 AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. LA - eng GR - L259068/Beijing Natural Science Foundation/ GR - 82204061/National Natural Science Foundation of China/ GR - 82373589/National Natural Science Foundation of China/ GR - SZSM 202311020/Sanming Project of Medicine in Shenzhen/ GR - CFH 2026-4G-2097/Capital's Funds for Health Improvement and Research/ PT - Journal Article PL - United States TA - Diabetes JT - Diabetes JID - 0372763 RN - 0 (Triglycerides) SB - IM MH - Humans MH - *Body Composition/physiology MH - Phenotype MH - Child MH - Male MH - Female MH - *Obesity MH - Body Mass Index MH - Absorptiometry, Photon MH - Algorithms MH - Triglycerides/blood MH - Adolescent MH - Adiposity/physiology EDAT- 2026/08/17 11:40 MHDA- 2026/09/21 17:47 CRDT- 2026/08/17 09:53 PHST- 2026/02/04 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/08/17 11:40 [pubmed] PHST- 2026/08/17 09:53 [entrez] AID - 172389 [pii] AID - 10.2337/db26-0136 [doi] PST - ppublish SO - Diabetes. 2026 Oct 1;75(10):1810-1822. doi: 10.2337/db26-0136. PMID- 42605004 OWN - NLM STAT- MEDLINE DCOM- 20261011 LR - 20261011 IS - 1365-2184 (Electronic) IS - 0960-7722 (Print) IS - 0960-7722 (Linking) VI - 59 IP - 10 DP - 2026 Oct TI - Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell-State Plasticity in the CFTR Modulator Era. PG - e70272 LID - 10.1111/cpr.70272 [doi] LID - e70272 AB - Cystic fibrosis (CF) has shifted from a fatal paediatric lung disease to a multi-organ, lifespan-spanning disorder in which gastrointestinal (GI) complications and malignancies are increasingly prominent. With improved survival into mid- and late adulthood, aided by newborn screening, optimised nutrition and the advent of highly effective CF transmembrane conductance regulator (CFTR) modulators, implementation of colonoscopic surveillance has highlighted a several-fold increase in early-onset colorectal cancer (CRC) and a broader spectrum of intestinal pathology. In parallel, work in mouse models, human tissue and patient-derived intestinal organoids now places the CFTR at the centre of a complex epithelial compartment that integrates ion and pH homeostasis, mucus biology, microbiota, redox balance and immune/stromal function. In this review, we advance the hypothesis that CF may be conceptualised as a niche-centric hereditary CRC predisposition syndrome, in which germline CFTR dysfunction chronically destabilises epithelial identity in addition to increasing mutational burden. We synthesise evidence that CFTR loss remodels stem cell regulation, promotes hypoxia and oxidative stress, perturbs microbial ecosystems, drives chronic immune activation and stromal remodelling, and induces epithelial-mesenchymal plasticity (EMP) and DNA-damage vulnerability, collectively creating a pre-neoplastic intestinal ecosystem. We situate this model within contemporary CRC frameworks that emphasise cell-state transitions, hybrid epithelial-mesenchymal (E/M) states and specialised stromal niches, and we distinguish it from oncofoetal reprogramming, an APC-driven programme that CF does not clearly recapitulate. We propose that CF may provide a naturally occurring human context in which chronic epithelial stress sustains EMP-like pressure, a concept that requires direct validation in human CF intestinal tissue. Finally, we consider how CFTR modulators, microbiome-directed therapies and redox-targeted interventions might re-programme the CF intestinal niche and outline experimental and clinical strategies needed to determine whether early, ecosystem-level correction can prevent GI cancers in this high-risk population. CI - (c) 2026 The Author(s). Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd. FAU - Umashankar, Bala AU - Umashankar B AUID- ORCID: 0000-0002-0796-5273 AD - School of Biomedical Sciences, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia. AD - Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, UNSW Sydney, Sydney, New South Wales, Australia. FAU - Pankonien, Ines AU - Pankonien I AD - BioISI-Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, Lisbon, Portugal. FAU - Amaral, Margarida AU - Amaral M AUID- ORCID: 0000-0002-0828-8630 AD - BioISI-Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, Lisbon, Portugal. FAU - Ooi, Chee Y AU - Ooi CY AUID- ORCID: 0000-0001-7111-0926 AD - Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, UNSW Sydney, Sydney, New South Wales, Australia. AD - Department of Gastroenterology, Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. AD - Sydney Children's Hospital Respiratory Department, Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. FAU - Jarde, Thierry AU - Jarde T AUID- ORCID: 0000-0001-7483-8672 AD - Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia. AD - Monash Biomedicine Discovery Institute, Clayton, Victoria, Australia. FAU - Waters, Shafagh A AU - Waters SA AUID- ORCID: 0000-0003-1144-5411 AD - School of Biomedical Sciences, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia. AD - Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, UNSW Sydney, Sydney, New South Wales, Australia. AD - Sydney Children's Hospital Respiratory Department, Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. LA - eng GR - NHMRC_APP1188987/National Health and Medical Research Council/ GR - Sydney Children Hospital Network Foundation/ GR - Luminesce Alliance Research/ PT - Journal Article PT - Review DEP - 20260816 PL - England TA - Cell Prolif JT - Cell proliferation JID - 9105195 RN - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator) SB - IM MH - Humans MH - *Cystic Fibrosis Transmembrane Conductance Regulator/metabolism/genetics MH - Animals MH - *Colorectal Neoplasms/pathology/metabolism MH - *Cystic Fibrosis/complications/pathology/metabolism MH - *Intestinal Mucosa/pathology/metabolism MH - Cell Plasticity PMC - PMC13478439 OTO - NOTNLM OT - CFTR OT - CFTR modulator therapy OT - colorectal cancer OT - cystic fibrosis OT - epithelial-mesenchymal plasticity OT - intestinal stem cells COIS- The authors declare no conflicts of interest. EDAT- 2026/08/17 05:38 MHDA- 2026/10/11 23:30 PMCR- 2026/08/16 CRDT- 2026/08/17 00:23 PHST- 2026/07/16 00:00 [revised] PHST- 2026/03/31 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/10/11 23:30 [medline] PHST- 2026/08/17 05:38 [pubmed] PHST- 2026/08/17 00:23 [entrez] PHST- 2026/08/16 00:00 [pmc-release] AID - CPR70272 [pii] AID - 10.1111/cpr.70272 [doi] PST - ppublish SO - Cell Prolif. 2026 Oct;59(10):e70272. doi: 10.1111/cpr.70272. Epub 2026 Aug 16. PMID- 42604984 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260817 IS - 1117-1936 (Print) VI - 33 IP - 5 DP - 2026 Sep 1 TI - Luteinising Hormone-to-follicle-stimulating Hormone Ratio for Predicting Unexplained Infertility in Patients with Hypovitaminosis D. PG - 574-578 LID - 10.4103/npmj.npmj_638_25 [doi] AB - BACKGROUND: Hypovitaminosis D critically influences reproductive hormones in women of reproductive age. The luteinising hormone (LH)/follicle-stimulating hormone (FSH) ratio predicts poor ovulatory response. OBJECTIVE: To evaluate the correlation between the LH/FSH ratio and hypovitaminosis D as a predictor of unexplained infertility in women. MATERIALS AND METHODS: The study was a cross-sectional study with retrospective data collection spanning 2 years, from January 2023 to December 2024, conducted in the Fertility and Gynecology of El Assrar Center of Oran (Algeria). Patients were segregated into the following groups (deficient group vs. insufficient group vs. sufficient group). RESULTS: During the study period, 200 patients were admitted. Hypovitaminosis D status was observed in 44.5%. The mean age was 32.24 +/- 6.39 years (range: 18-47). In the deficient group, serum LH concentrations were markedly lower compared to the insufficient and sufficient groups (LH = 5.80 +/- 3.31 UI/L vs. 8.83 +/- 6.90 UI/L vs. 6.48 +/- 4.00 UI/L, P = 0.018; respectively). In contrast, the LH/FSH ratio was statistically higher in the deficient group compared to the insufficient and sufficient groups (LH/FSH ratio = 1.67 +/- 1.88 vs. 0.94 +/- 0.59 vs. 1.02 +/- 0.64, P = 0.018; respectively). In addition, the results revealed that the 4th quartile (odds ratios = 11.37 [4.13-22.00], P = 0.021) of LH/FSH ratio was statistically higher in patients with Vitamin D insufficiency and deficiency. The LH/FSH ratio was a significant predictor for unexplained infertility with a diagnostic accuracy of 0.724. CONCLUSIONS: Elevated LH/FSH ratio in women with hypovitaminosis D is significantly linked to unexplained infertility. Therefore, the LH/FSH ratio can serve as a reliable clinical marker for predicting successful pregnancy when evaluated alongside Vitamin D levels. CI - Copyright (c) 2026 Nigerian Postgraduate Medical Journal. FAU - Hamri, Walid Hassene AU - Hamri WH AD - Department of Biology, Faculty of Natural and Life Sciences, Mustapha Stambouli University, Mascara, Algeria. AD - Laboratory of Nutrition, Pathology, Agro-Biotechnology, and Health, Sidi-Bel-Abbes, Algeria. FAU - Chenni, Fatima Zohra AU - Chenni FZ AD - Department of Biology, Biotoxicology Laboratory, Faculty of Natural and Life Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. FAU - Mirali, Chahnez Hadj Slimane AU - Mirali CHS AD - Fertility and Gynecology of Makhzan El Assrar Center, Oran, Algeria. LA - eng PT - Journal Article DEP - 20260817 PL - Nigeria TA - Niger Postgrad Med J JT - The Nigerian postgraduate medical journal JID - 9613595 RN - 9002-67-9 (Luteinizing Hormone) RN - 9002-68-0 (Follicle Stimulating Hormone) RN - 1406-16-2 (Vitamin D) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Vitamin D Deficiency/complications/blood MH - *Luteinizing Hormone/blood MH - Cross-Sectional Studies MH - Adult MH - Retrospective Studies MH - *Infertility, Female/blood/etiology/diagnosis MH - *Follicle Stimulating Hormone/blood MH - Middle Aged MH - Adolescent MH - Young Adult MH - Vitamin D/blood MH - Biomarkers/blood MH - Predictive Value of Tests OTO - NOTNLM OT - Hypovitaminosis D OT - luteinising hormone/follicle-stimulating hormone ratio OT - reproductive hormones OT - unexplained infertility EDAT- 2026/08/17 05:38 MHDA- 2026/08/17 05:39 CRDT- 2026/08/17 00:04 PHST- 2025/11/28 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/08/17 05:39 [medline] PHST- 2026/08/17 05:38 [pubmed] PHST- 2026/08/17 00:04 [entrez] AID - 00130415-202609000-00004 [pii] AID - 10.4103/npmj.npmj_638_25 [doi] PST - ppublish SO - Niger Postgrad Med J. 2026 Sep 1;33(5):574-578. doi: 10.4103/npmj.npmj_638_25. Epub 2026 Aug 17. PMID- 42604857 OWN - NLM STAT- Publisher LR - 20260816 IS - 1557-9034 (Electronic) IS - 1092-6429 (Linking) DP - 2026 Aug 16 TI - Robotic Pancreaticoduodenectomy in Pediatric Patients: First Two Reported Cases in the United States. PG - 10926429261478780 LID - 10.1177/10926429261478780 [doi] AB - BACKGROUND: Pancreaticoduodenectomy (Whipple procedure) is rarely required in children, but remains the standard of care for resectable pancreatic head tumors. Robotic pancreaticoduodenectomy (RPD) has been increasingly performed in adults, demonstrating safety, feasibility, and in some series, superior perioperative outcomes compared with open surgery. In children, however, there are only three published case reports worldwide. METHODS: We describe two adolescent females with pancreatic head solid pseudopapillary neoplasms (SPNs) who underwent RPD at high-volume U.S. CENTERS: Both cases were managed by multidisciplinary teams including pediatric surgeons and adult surgical oncologists experienced in robotic pancreatic surgery. RESULTS: Case 1: A 13-year-old underwent robotic pylorus-preserving pancreaticoduodenectomy utilizing intraoperative Indocyanine Green Firefly and ultrasound to assess critical anatomy. Reconstruction was performed with Blumgart pancreaticojejunostomy and hepaticojejunostomy. She advanced to diet by postoperative day (POD) 3 and was discharged on POD 3. Case 2: A 17-year-old underwent RPD with pylorus preservation in a similar fashion at an adult hospital. Her recovery was uncomplicated, drains were removed on POD 4, and she was discharged on POD 5. Final pathology in both patients confirmed SPN with negative margins. CONCLUSIONS: These represent the first pediatric RPDs reported in the United States and the first using the da Vinci Xi platform. Our experience demonstrates that pediatric RPD is feasible and safe when performed in collaboration with high-volume adult robotic pancreatic programs. Given the rarity of pediatric pancreatic tumors, collaborative registries and continued reporting are essential to define outcomes and guide best practice. FAU - Zamora, Irving J AU - Zamora IJ AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Sims, Jessica K AU - Sims JK AD - Vanderbilt University School of Medicine, Nashville, Tennessee, USA. FAU - Gupta, Vikas S AU - Gupta VS AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - D'Cruz, Roshan J AU - D'Cruz RJ AD - Department of Pediatric Surgery, Medical College of Georgia, Augusta, Georgia, USA. FAU - Jacobson, Jillian AU - Jacobson J AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Chara, Alejandro O AU - Chara AO AUID- ORCID: 0009-0009-0408-0830 AD - Department of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Johnson, Kevin N AU - Johnson KN AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Gamboa, Anthony M AU - Gamboa AM AD - Department of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Benedetti, Daniel J AU - Benedetti DJ AUID- ORCID: 0000-0003-1524-3518 AD - Department of Pediatric Hematology/Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Polanco, Patricio M AU - Polanco PM AD - Department of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. FAU - Zeh, Herbert J 3rd AU - Zeh HJ 3rd AD - Department of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. FAU - Padmanaban, Sekhar AU - Padmanaban S AD - Department of Surgical Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Lovvorn, Harold N 3rd AU - Lovvorn HN 3rd AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Pandya, Samir AU - Pandya S AD - Department of Pediatric Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. LA - eng PT - Journal Article DEP - 20260816 PL - United States TA - J Laparoendosc Adv Surg Tech A JT - Journal of laparoendoscopic & advanced surgical techniques. Part A JID - 9706293 SB - IM OTO - NOTNLM OT - pancreaticoduodenectomy OT - pediatric surgery OT - robotic surgery OT - surgical education EDAT- 2026/08/16 23:36 MHDA- 2026/08/16 23:36 CRDT- 2026/08/16 22:33 PHST- 2026/08/16 23:36 [medline] PHST- 2026/08/16 23:36 [pubmed] PHST- 2026/08/16 22:33 [entrez] AID - 10.1177/10926429261478780 [doi] PST - aheadofprint SO - J Laparoendosc Adv Surg Tech A. 2026 Aug 16:10926429261478780. doi: 10.1177/10926429261478780. PMID- 42604540 OWN - NLM STAT- Publisher LR - 20260825 IS - 1754-9515 (Electronic) IS - 1754-9507 (Linking) DP - 2026 Aug 16 TI - Assessment and diagnosis of Paediatric Feeding Disorder: A scoping review of assessment tools and psychometric properties. PG - 1-13 LID - 10.1080/17549507.2026.2713492 [doi] AB - PURPOSE: Paediatric Feeding Disorder occurs when oral intake is not age-appropriate and associated with impaired medical, nutritional, feeding skill, and/or psychosocial dysfunction. Psychometric properties of feeding assessments are variable, with unclear mapping to the Paediatric Feeding Disorder criteria. We aimed to explore paediatric feeding and swallowing assessment tools mapped to Paediatric Feeding Disorder domains and narratively analyse the psychometric properties. METHOD: This systematic scoping review utilised three databases (Medline, Embase, Web of Science). Studies written in English regarding children 0;6 months to 3;11 years with psychometrics on assessment of Paediatric Feeding Disorder were included. RESULT: 32,322 papers met inclusion criteria, and 137 papers were included in final extraction. Ninety-five feeding assessments were identified; 66.3% parent-reported questionnaires, 31.6% clinician assessments, and 2.1% clinician or caregiver rating scales. Of these, 87% of assessments included a combination of Paediatric Feeding Disorder domains. Psychometric properties were reported on 520 occasions, the highest being internal consistency (13.5%). CONCLUSION: Diagnosis of Paediatric Feeding Disorder requires use of feeding assessments with the strongest psychometric evidence to comprehensively assess all four Paediatric Feeding Disorder domains. Assessments should incorporate parent-reported and clinician assessment to synergise caregiver perspectives with clinical expertise. Further research is needed to enhance reliability and validity testing of paediatric feeding assessments to form a comprehensive Paediatric Feeding Disorder diagnosis. FAU - Wanless, Rachel AU - Wanless R AUID- ORCID: 0000-0003-2528-0945 AD - Curtin University, Perth, Australia. FAU - Claessen, Mary AU - Claessen M AUID- ORCID: 0000-0002-1087-5041 AD - Speech Pathology Australia, Melbourne, Australia. FAU - Gucciardi, Daniel F AU - Gucciardi DF AUID- ORCID: 0000-0001-5448-3990 AD - Curtin University, Perth, Australia. FAU - Smart, Sharon AU - Smart S AUID- ORCID: 0000-0002-5882-4673 AD - Curtin University, Perth, Australia. LA - eng PT - Journal Article PT - Review DEP - 20260816 PL - England TA - Int J Speech Lang Pathol JT - International journal of speech-language pathology JID - 101320232 SB - IM OTO - NOTNLM OT - Paediatric Feeding Disorder OT - assessment OT - diagnosis OT - feeding OT - psychometrics OT - swallowing EDAT- 2026/08/16 17:36 MHDA- 2026/08/16 17:36 CRDT- 2026/08/16 11:42 PHST- 2026/08/16 17:36 [pubmed] PHST- 2026/08/16 17:36 [medline] PHST- 2026/08/16 11:42 [entrez] AID - 10.1080/17549507.2026.2713492 [doi] PST - aheadofprint SO - Int J Speech Lang Pathol. 2026 Aug 16:1-13. doi: 10.1080/17549507.2026.2713492. PMID- 42603809 OWN - NLM STAT- Publisher LR - 20260815 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Aug 15 TI - Associations of mental health with subsequent weight development during a 4-year follow-up in adolescence. LID - 10.1038/s41390-026-05361-1 [doi] AB - BACKGROUND: Although obesity and mental health problems represent two of the most pressing public health challenges, their developmental interplay remains insufficiently understood. Thus, we examined how depressive and anxiety symptoms, self-esteem, and psychological resilience are associated with weight development during adolescence. METHODS: We included 1280 11-year-old children from the Finnish Health in Teens cohort, following 814 of them for 4.3 years. Mental health was assessed with validated self-administered scales at age 11. Psychological resilience was determined by complete mental health after exposure to stressful life events. Body mass index z-score (BMIz) and waist-to-height ratio (WtHr) were calculated at ages 11 and 16. RESULTS: In models adjusted for sex, age, physical activity, dietary pattern, puberty status, caregivers' BMI and education level, depressive symptoms were associated with higher baseline BMIz but smaller increases in mean BMIz thereafter (p = 0.030). High self-esteem was associated with lower baseline BMIz, yet with steeper increases over follow-up (adjusted model, p = 0.021). Anxiety symptoms and resilience were not associated with BMIz after adjustments. Similar patterns were observed for WtHr. CONCLUSION: Findings highlight that mental health is associated with physical growth in adolescence, emphasizing the need to consider mental health in understanding and addressing patterns of weight development and their underlying dynamics. IMPACT: This study provides up-to-date, longitudinal evidence on how mental health shapes subsequent weight development during the critical and rapid growth period of adolescence. Both positive and negative dimensions of mental health play a role in shaping adolescent weight development, with evidence that some youths experiencing mental health difficulties exhibited smaller increases in BMI z-score, even when starting from a higher baseline BMI. It should be acknowledged that in contemporary society, adolescents with mental health difficulties may not necessarily present immediate excessive weight gain but instead follow stable or even declining weight trajectories. CI - (c) 2026. The Author(s). FAU - Ankkuri, Emilia AU - Ankkuri E AD - Folkhalsan Research Centre, Helsinki, Finland. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Lommi, Sohvi AU - Lommi S AD - Folkhalsan Research Centre, Helsinki, Finland. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Granroth-Wilding, Hanna AU - Granroth-Wilding H AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Lahti, Jari AU - Lahti J AD - Folkhalsan Research Centre, Helsinki, Finland. AD - Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Viljakainen, Heli AU - Viljakainen H AD - Folkhalsan Research Centre, Helsinki, Finland. heli.viljakainen@helsinki.fi. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. heli.viljakainen@helsinki.fi. LA - eng PT - Journal Article DEP - 20260815 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Informed consent: Written informed consent was obtained from Finnish Health in Teens participating adolescents and their caregivers. EDAT- 2026/08/16 05:35 MHDA- 2026/08/16 05:35 CRDT- 2026/08/15 23:28 PHST- 2025/09/19 00:00 [received] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/06/15 00:00 [revised] PHST- 2026/08/16 05:35 [medline] PHST- 2026/08/16 05:35 [pubmed] PHST- 2026/08/15 23:28 [entrez] AID - 10.1038/s41390-026-05361-1 [pii] AID - 10.1038/s41390-026-05361-1 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Aug 15. doi: 10.1038/s41390-026-05361-1. PMID- 30422475 STAT- Publisher CTDT- 20260816 PB - StatPearls Publishing DP - 2026 Jan TI - Saphenous Vein Cutdown. BTI - StatPearls AB - Rapid establishment of venous access is essential for treating and resuscitating critically ill and injured individuals. Recent Advanced Trauma Life Support (ATLS) guidelines prioritize hemorrhage control over airway management, emphasizing intravascular access and volume resuscitation in certain scenarios. Adequate venous access facilitates blood draws for diagnostics and enables delivery of intravenous (IV) fluids, blood products, and medications. Peripheral IV placement may be difficult in patients with intravascular volume depletion, peripheral vascular diseases, aberrant vascular anatomy, high body mass index, young age (particularly neonatal and young pediatric patients), history of IV drug use, history of repeated IV or central line placement, and extremity trauma, among other factors. Venous cutdown procedures were more often performed when traditional IV placement failed before the introduction of alternative IV access techniques in the 2000s. Ultrasound-guided peripheral IV placement, intraosseous access devices, and Seldinger techniques have largely replaced venous cutdowns for emergent IV access. Notably, central line placement is not often practical in a chaotic resuscitation, nor does it confer benefits over large-bore peripheral access for treatment of acutely hypotensive or hemorrhaging patients. When other techniques have failed or are not feasible, venous cutdown procedures may be needed to secure peripheral IV access. Historically, cutdown of the proximal greater saphenous vein (GSV) near the saphenofemoral junction in the upper thigh was also used for quick IV access. Proximal GSV cutdown has fallen out of favor in adult patients due to its deeper location and proximity to other major neurovascular structures. This method is still described in recent pediatric surgical literature as a potential venous cutdown site in small children. Cutdown techniques for veins in the cervical region and upper extremity have also been described. Cutdown to the vessels in the neck and groin may still be performed in other scenarios, such as for cannulation for extracorporeal membrane oxygenation (ECMO) and in vascular surgery. This review focuses primarily on cutdown of the distal GSV at the ankle, as this location is the optimal site for lower extremity venous cutdown because of its predictable superficial position and distance from the torso. CI - Copyright (c) 2026, StatPearls Publishing LLC. FAU - McMahon, Kathleen AU - McMahon K AD - Cedars Sinai Marina Del Rey Hospital, Kaiser Permanente FAU - Anand, Sachit AU - Anand S AD - All India Institute of Medical Sciences FAU - Loyd, Joshua W AU - Loyd JW AD - Novant Health LA - eng PT - Study Guide PT - Book Chapter PL - Treasure Island (FL) COIS- Disclosure: Kathleen McMahon declares no relevant financial relationships with ineligible companies. Disclosure: Sachit Anand declares no relevant financial relationships with ineligible companies. Disclosure: Joshua W Loyd declares no relevant financial relationships with ineligible companies. EDAT- 2026/08/16 00:00 CRDT- 2026/08/16 00:00 AID - NBK532880 [bookaccession] PMID- 42602839 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260815 LR - 20260816 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 12 IP - 3 DP - 2026 TI - Exploring the impact of revised physical activity guidelines on children and adolescents: an analysis of large Australian and New Zealand studies. PG - e003119 LID - 10.1136/bmjsem-2025-003119 [doi] LID - e003119 AB - OBJECTIVES: Around 80% of children/adolescents globally do not meet recommended levels of physical activity (PA). The 2020 WHO consensus updated PA guidelines, changing from '60 minutes of PA/day' to at least 'an average of 60 min/day'. This means that attaining 420 min/week expresses the minimum threshold for PA.This analysis examined the effects of the changed guidelines on children/adolescents meeting PA guidelines. A coprimary research question examines single-item PA questions to determine the number of days of 60 min of activity that best reflect meeting the new PA guideline. METHODS: Data were from five population-level Australian and New Zealand surveys (two representative population surveillance datasets and three large community interventions). PA questions included the single item question (days/week of 60 min) and detailed PA measures including International Physical Activity Questionnaire-adolescent questions. The single-item analysis used receiver operating characteristic (ROC) curves to identify the best fit between the single-item and more extensive PA measures (maximising sensitivity and specificity). RESULTS: The proportion meeting the old PA guidelines ranged from 28-55%, compared with 35-84% meeting the new guideline (average absolute increase of 26.2%). ROC analysis described areas under the ROC curve between 0.728 and 0.907. The best fit (Youden's Index >0.5) was 4-5 days/week where the single item best classified children and adolescents meeting the new guideline. CONCLUSIONS: The new guideline classified 26% more children and adolescents meeting updated PA guidelines. National research reports should use updated PA guideline criteria, and for surveillance, 4-5 reported days/week on the single PA question best estimates meeting the PA guideline threshold. CI - Copyright (c) World Health Organization 2026. Licensee BMJ. FAU - Bauman, Adrian AU - Bauman A AUID- ORCID: 0000-0002-0369-4621 AD - Sydney School of Public Health, Prevention Research Collaboration, The University of Sydney, Sydney, New South Wales, Australia. FAU - Owen, Katherine AU - Owen K AUID- ORCID: 0000-0001-5248-3030 AD - The University of Sydney, Sydney, New South Wales, Australia. FAU - Smith, Janette L AU - Smith JL AD - NSW Ministry of Health Population and Public Health Division, St Leonards, New South Wales, Australia. FAU - Wolfenden, Luke AU - Wolfenden L AD - School of Medicine and Public Health, The University of Newcastle Australia, Newcastle, New South Wales, Australia. FAU - Nathan, Nicole AU - Nathan N AUID- ORCID: 0000-0002-7726-1714 AD - School of Medicine and Public Health, The University of Newcastle Australia, Newcastle, New South Wales, Australia. FAU - Richards, Justin AU - Richards J AD - Te Hau Kori - Centre for Physical Activity and Wellbeing, Victoria University of Wellington, Wellington, New Zealand. LA - eng PT - Journal Article DEP - 20260812 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC13475078 OTO - NOTNLM OT - Exercise OT - Physical activity OT - Surveillance COIS- None declared. EDAT- 2026/08/15 13:47 MHDA- 2026/08/15 13:48 PMCR- 2026/08/12 CRDT- 2026/08/15 06:11 PHST- 2025/11/24 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/08/15 13:48 [medline] PHST- 2026/08/15 13:47 [pubmed] PHST- 2026/08/15 06:11 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - bmjsem-2025-003119 [pii] AID - 10.1136/bmjsem-2025-003119 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2026 Aug 12;12(3):e003119. doi: 10.1136/bmjsem-2025-003119. eCollection 2026. PMID- 42602124 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260815 LR - 20260816 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - Evaluation of a Caregiver-Completed Questionnaire for Assessing Early Childhood Caries Risk: A Cross-Sectional Study. PG - e112685 LID - 10.7759/cureus.112685 [doi] LID - e112685 AB - Introduction Early childhood caries (ECC) is one of the most prevalent chronic diseases affecting preschool children worldwide and can adversely affect oral health, nutrition, growth, and quality of life. Early identification of children at risk is essential for implementing timely preventive interventions. Caregiver-completed screening tools may offer a simple and cost-effective approach to identifying children who require further dental evaluation. Therefore, the present study aimed to evaluate the diagnostic performance of a self-developed, caregiver-completed questionnaire for identifying ECC among preschool children, using clinical examination as the reference standard. Materials and methods A cross-sectional study was conducted among 150 caregiver-child dyads, including children aged 3-6 years. Caregivers completed a self-developed, 15-item questionnaire covering feeding practices, dietary habits, oral hygiene practices, dental history, and caregiver-related factors. Content validation was performed by an expert panel, followed by pilot testing and reliability assessment. All children subsequently underwent a clinical examination for the diagnosis of ECC. Internal consistency was evaluated using Cronbach's alpha. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal questionnaire cutoff score. Sensitivity, specificity, predictive values, likelihood ratios, area under the curve (AUC), and Cohen's kappa were calculated. Results Clinical examination identified ECC in 90 (60.0%) children, while 60 (40.0%) children did not have ECC. Questionnaire scores were significantly higher among children with ECC (19.4 +/- 4.6) than among those without ECC (10.2 +/- 3.8; p < 0.001). The questionnaire demonstrated good internal consistency, with an overall Cronbach's alpha of 0.86. ROC curve analysis revealed an AUC of 0.884 (95% CI: 0.830-0.938). The optimal cutoff score was >/=15, yielding a sensitivity of 82.2%, specificity of 86.7%, positive predictive value of 90.2%, and negative predictive value of 76.5%. The positive and negative likelihood ratios were 6.17 and 0.205, respectively. Agreement analysis demonstrated an observed agreement of 84.0% and a Cohen's kappa coefficient of 0.672, indicating substantial agreement with the clinical diagnosis. Conclusion The caregiver-completed ECC questionnaire demonstrated good reliability, substantial agreement with clinical examination findings, and good diagnostic performance as a screening tool. The questionnaire may serve as a simple, non-invasive, and cost-effective tool for the early identification of children with or at risk of ECC and may facilitate timely preventive interventions in community and clinical settings. CI - Copyright (c) 2026, Gunnam et al. FAU - Gunnam, Divya Sree AU - Gunnam DS AD - Department of Public Health, Master of Public Health, University of New Haven, West Haven, USA. FAU - Ravikumar, Akshitha AU - Ravikumar A AD - Department of Public Health Dentistry, Panineeya Institute of Dental Sciences and Research Centre, Hyderabad, IND. FAU - Chokshi, Akshat A AU - Chokshi AA AD - Department of Dentistry, Taunton Village Dental, Oshawa, CAN. FAU - Chauhan, Sameer AU - Chauhan S AD - Department of Prosthodontics, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth (Deemed to be University), Vadodara, IND. FAU - Sreedhar, Gayathri AU - Sreedhar G AD - Department of Public Health Dentistry, Azeezia College of Dental Sciences and Research, Adichanalloor, IND. FAU - Kumar B, Prashanth AU - Kumar B P AD - Department of Pedodontics and Preventive Dentistry, Tirumala Institute of Dental Sciences and Research Centre, Nizamabad, IND. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13473709 OTO - NOTNLM OT - caregivers OT - dental caries risk assessment OT - early childhood caries OT - oral health screening OT - questionnaires COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, Azeezia College of Dental Sciences and Research, Kollam, Kerala, India issued approval AEC/2022/29. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/15 13:47 MHDA- 2026/08/15 13:48 PMCR- 2026/07/14 CRDT- 2026/08/15 05:11 PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/15 13:48 [medline] PHST- 2026/08/15 13:47 [pubmed] PHST- 2026/08/15 05:11 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.7759/cureus.112685 [doi] PST - epublish SO - Cureus. 2026 Jul 14;18(7):e112685. doi: 10.7759/cureus.112685. eCollection 2026 Jul. PMID- 42602011 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260815 LR - 20260816 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Analysis of influencing factors and nomogram of attention-deficit hyperactivity disorder in school-age children. PG - 1830784 LID - 10.3389/fpsyt.2026.1830784 [doi] LID - 1830784 AB - INTRODUCTION: Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in school-aged children (6-13 years) that can lead to significant functional impairment if not identified early. This study aims to identify factors associated with ADHD among school-age children and evaluate the predictive value of a risk nomogram. METHODS: We conducted a retrospective study including 155 school-age children diagnosed with ADHD at the Minhang District Mental Health Centre (Shanghai) between June 2022 and May 2025, and 155 age-matched healthy controls who underwent physical examination during the same period. Clinical and demographic data were collected via standardized questionnaires. Logistic regression analyses were performed to identify risk factors, and a nomogram prediction model was constructed. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration plots, and the Hosmer-Lemeshow test. RESULTS: Multivariate logistic analysis identified maternal alcohol consumption during pregnancy (OR = 6.975), maternal smoking during pregnancy (OR = 3.785), maternal anxiety and depression during pregnancy (OR = 3.826), family history of ADHD (OR = 9.449), parental violence (OR = 3.369), difficulty falling asleep (OR = 7.317), and daily screen time >/= 2 hours (OR = 1.755) as independent risk factors for ADHD. Family harmony was identified as a protective factor (OR = 0.455). The nomogram prediction model demonstrated good discriminative ability with an AUC of 0.817 (95% CI: 0.769-0.864) at a cut-off value of logit(P) > 0.471. The model showed satisfactory calibration (Hosmer-Lemeshow test, P = 0.355) with a sensitivity of 75.48% and specificity of 76.77%. DISCUSSION: ADHD in school-age children is influenced by multiple factors, including prenatal exposures, family environment, sleep patterns, and daily screen time. The nomogram prediction model developed in this study demonstrates good predictive performance and may serve as a preliminary tool for early identification of at-risk children, though external validation is needed before clinical implementation. These findings highlight the importance of targeted preventive interventions addressing modifiable risk factors, particularly focusing on prenatal care, family harmony, sleep hygiene, and screen time management, to reduce the probability of ADHD in school-age children. CI - Copyright (c) 2026 Li, Zhang, Jiang, Tao, Wang and Jin. FAU - Li, Bo AU - Li B AD - Shanghai Minhang District Mental Health Center, Shanghai, China. FAU - Zhang, Wei Bo AU - Zhang WB AD - Shanghai Mental Health Center, Shanghai, China. FAU - Jiang, Chao AU - Jiang C AD - Shanghai Minhang District Mental Health Center, Shanghai, China. FAU - Tao, Jing AU - Tao J AD - Shanghai Mental Health Center, Shanghai, China. FAU - Wang, Li Na AU - Wang LN AD - Shanghai Minhang District Mental Health Center, Shanghai, China. FAU - Jin, Jin AU - Jin J AD - Shanghai Mental Health Center, Shanghai, China. LA - eng PT - Journal Article DEP - 20260731 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13473084 OTO - NOTNLM OT - ADHD OT - nomogram OT - prediction model OT - risk factors OT - school-aged children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/15 05:36 MHDA- 2026/08/15 05:37 PMCR- 2026/07/31 CRDT- 2026/08/15 04:59 PHST- 2026/03/14 00:00 [received] PHST- 2026/05/30 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/08/15 05:37 [medline] PHST- 2026/08/15 05:36 [pubmed] PHST- 2026/08/15 04:59 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1830784 [doi] PST - epublish SO - Front Psychiatry. 2026 Jul 31;17:1830784. doi: 10.3389/fpsyt.2026.1830784. eCollection 2026. PMID- 42601769 OWN - NLM STAT- MEDLINE DCOM- 20260815 LR - 20260819 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 33 DP - 2026 Aug 14 TI - Central adiposity reflected by the weight-adjusted waist index and spirometric parameters in US children and adolescents: A cross-sectional analysis of NHANES 2007 to 2012. PG - e50200 LID - 10.1097/MD.0000000000050200 [doi] LID - e50200 AB - Obesity impairs pulmonary function. This study aimed to investigate the potential relationship between the weight-adjusted waist index (WWI), a novel metric for measuring adiposity, and pulmonary function in children and adolescents. This cross-sectional study used extensive data on WWI and pulmonary function metrics from the 2007 to 2012 National Health and Nutrition Examination Survey. The WWI calculation entails dividing waist circumference (cm) by the square root of weight (kg). Z-scores for each lung function measure were derived from Global Lung Function Initiative references. We employed a weighted multivariate logistic regression model to ascertain the association between lung function and WWI. The application of smooth curve fitting validated the linearity of the relationships. Subgroup analysis and evaluation of interactions were conducted as well. Across all statistical models, no significant association was observed between WWI and forced expiratory volume in 1 second (FEV1) z-score. However, WWI demonstrated a significant positive correlation with forced vital capacity (FVC) z-score. Importantly, a significant negative correlation was consistently found between WWI and FEV1/FVC z-score. In the model with all adjustments, each unit rise in WWI was associated with a decrease of 0.395 in FEV1/FVC z-score (beta = -0.395, 95% confidence interval: -0.496, -0.295) and an increase of 0.292 in FVC z-score (beta = 0.292, 95% confidence interval: 0.186, 0.398). This study finds a significant negative association between WWI and FEV1/FVC z-score. This highlights the necessity for sustained WWI surveillance to guide public health initiatives. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Wu, Meijuan AU - Wu M AD - Department of Pulmonary and Critical Care Medicine, The Second Hospital of Sanming, Sanming, Fujian Province, PR China. FAU - Xie, Qihua AU - Xie Q FAU - Zhang, Aimei AU - Zhang A FAU - Lin, Yongping AU - Lin Y LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Nutrition Surveys MH - Female MH - Child MH - United States/epidemiology MH - Male MH - *Waist Circumference/physiology MH - Spirometry MH - Forced Expiratory Volume/physiology MH - Vital Capacity/physiology MH - *Obesity, Abdominal/physiopathology/epidemiology MH - *Adiposity/physiology PMC - PMC13480898 OTO - NOTNLM OT - NHANES OT - children and adolescents OT - obesity OT - pulmonary function OT - weight-adjusted waist index COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/08/15 05:36 MHDA- 2026/08/15 05:37 PMCR- 2026/08/14 CRDT- 2026/08/15 01:00 PHST- 2026/01/27 00:00 [received] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/15 05:37 [medline] PHST- 2026/08/15 05:36 [pubmed] PHST- 2026/08/15 01:00 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 00005792-202608140-00097 [pii] AID - MD-D-26-01188 [pii] AID - 10.1097/MD.0000000000050200 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 14;105(33):e50200. doi: 10.1097/MD.0000000000050200. PMID- 42601187 OWN - NLM STAT- Publisher LR - 20260928 IS - 1468-6244 (Electronic) IS - 0022-2593 (Print) IS - 0022-2593 (Linking) DP - 2026 Aug 14 TI - Childhood-onset neurodegeneration and brain atrophy: defining UBTF-related developmental regression and progressive ataxia. LID - jmg-2025-111356 [pii] LID - 10.1136/jmg-2025-111356 [doi] AB - BACKGROUND: The heterozygous variant c.628G>A (p.Glu210Lys) in UBTF (upstream binding transcription factor) causes childhood-onset neurodegeneration with brain atrophy (CONDBA) (OMIM # 600673), characterised by early normal or mildly delayed development followed by regression, with individuals frequently experiencing movement disorders. This study defines the natural history of this rare disorder and explores potential biomarkers in humans and mice. METHODS: Caregivers of individuals with CONDBA completed cross-sectional surveys detailing genetic, developmental and clinical features. Patients evaluated in a neurogenetics clinic underwent Brief Ataxia Rating Scale (BARS) assessments compared with remotely collected wrist and ankle accelerometry data. Neurofilament light chain (NFL) levels were assessed in the clinic cohort and in a Ubtf E210K knock-in mouse model. RESULTS: All 11 caregiver surveys reported onset of neurodevelopmental regression (median 3.5 years, range 0.5-5 years), at times following anaesthesia or illness and 82% developed ataxia. Motor activity data from five participants (median 11.8 years, range 8.1-12.5 years) had high test-retest reliability, correlated with ataxia severity as measured by the BARS, and showed declines across multiple measures over the study period. NFL was abnormally elevated in both humans and the mouse model. CONCLUSION: UBTF-related CONDBA presents with early normal or mildly delayed development followed by regression and progressive ataxia. Wearable accelerometers provide a reliable measure of disease severity, and elevated NFL may serve as a biomarker of neuronal injury in both humans and animal models. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Nagy, Amanda AU - Nagy A AUID- ORCID: 0000-0001-8116-4805 AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA anagy2@mgb.org. FAU - Luddy, Anna AU - Luddy A AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Molay, Francine AU - Molay F AD - Division of Clinical Research, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - McLaughlin, Haley AU - McLaughlin H AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - De La Rosa Abreu, Lizbeth AU - De La Rosa Abreu L AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Becker, Catherine AU - Becker C AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Terrey, Markus AU - Terrey M AD - Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, Maine, USA. FAU - Lutz, Cathleen M AU - Lutz CM AD - Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, Maine, USA. AD - JAX Center for Precision Genetics, The Jackson Laboratory, Bar Harbor, Maine, USA. FAU - Gupta, Anoopum AU - Gupta A AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Eichler, Florian S AU - Eichler FS AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. LA - eng GR - R01 NS134597/NS/NINDS NIH HHS/United States GR - U42 OD010921/OD/NIH HHS/United States GR - U54 NS115052/NS/NINDS NIH HHS/United States GR - U54 OD030187/OD/NIH HHS/United States PT - Journal Article DEP - 20260814 PL - England TA - J Med Genet JT - Journal of medical genetics JID - 2985087R SB - IM PMC - PMC13614006 MID - NIHMS2209294 OTO - NOTNLM OT - Central Nervous System Diseases OT - Cerebellar Diseases OT - Movement Disorders OT - Neurodegenerative Diseases OT - Pediatrics COIS- Competing interests: For the methods for extracting and characterising submovements from wearable sensor data, a PCT (US2022/081374) was filed on 12 December 2022, titled 'System and method for clinical disorder assessment'. An earlier US Provisional Application (Serial No. 63/288,619) was filed on 12 December 2021. The patent applicant is the institution (Massachusetts General Hospital) and inventor is AG. EDAT- 2026/08/14 23:37 MHDA- 2026/08/14 23:37 PMCR- 2026/09/25 CRDT- 2026/08/14 21:23 PHST- 2025/11/11 00:00 [received] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/14 23:37 [medline] PHST- 2026/08/14 23:37 [pubmed] PHST- 2026/08/14 21:23 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - jmg-2025-111356 [pii] AID - 10.1136/jmg-2025-111356 [doi] PST - aheadofprint SO - J Med Genet. 2026 Aug 14:jmg-2025-111356. doi: 10.1136/jmg-2025-111356. PMID- 42600340 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260831 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 162 DP - 2026 Nov TI - The effect of psychological flexibility level and pregnancy stress on traumatic birth perception and breastfeeding success in primiparous pregnant women in the latent phase. PG - 104937 LID - S0266-6138(26)00241-X [pii] LID - 10.1016/j.midw.2026.104937 [doi] AB - BACKGROUND: Pregnancy and childbirth are significant life events that can affect women's mental health and maternal functioning. Psychological flexibility, defined as the ability to adapt to changing situations and maintain balance under stress, plays a crucial role in this process. This study aimed to examine the effects of psychological flexibility and pregnancy stress on the perception of traumatic birth and breastfeeding success among primiparous pregnant women in the latent phase. METHODS: This cross-sectional study was carried out between January 2021 and June 2022 at a training and research hospital in eastern Turkiye. The study sample consisted of 310 primiparous pregnant women, selected through simple random sampling among eligible participants admitted in the latent phase of labor. Data were collected using the Personal Information Form, Psychological Flexibility Scale, Pregnancy Stress Rating Scale, Traumatic Birth Perception Scale, and LATCH Breastfeeding Assessment Tool. Data were analyzed using descriptive statistics, Pearson correlation analysis, and path analysis based on structural equation modeling (SEM). RESULTS: The study found a significant negative correlation between psychological flexibility and traumatic birth perception (r = -.183, p < .001) and was positively correlated with breastfeeding success (r = .208, p < .001). Pregnancy stress was positively correlated with the perception of traumatic birth (r = .472, p < .001) and negatively correlated with breastfeeding success (r = -.263, p < .001). Path analysis demonstrated that psychological flexibility had a significant negative effect on traumatic birth perception (beta = -.159, p = .001) and a significant positive effect on breastfeeding success (beta = .214, p < .001). Pregnancy stress had a significant positive effect on traumatic birth perception (beta = .468, p < .001) and a significant negative effect on breastfeeding success (beta = -.257, p < .001). CONCLUSION: Increased psychological flexibility was associated with a lower perception of traumatic birth and higher breastfeeding success. Conversely, higher pregnancy stress was linked to higher traumatic birth perception and lower breastfeeding success. These findings highlight the importance of integrating psychological flexibility-based interventions into prenatal education and midwifery care to promote maternal mental health and breastfeeding outcomes. In addition, future studies could explore intervention programs designed to enhance psychological flexibility among pregnant women to prevent traumatic birth experiences and improve postpartum adaptation. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Gezer Tekdal, Aysegul AU - Gezer Tekdal A AD - Adiyaman University, Faculty of Health Sciences, Department of Midwifery, Altinsehir, Ataturk Blv. No: 1, Adiyaman, 02040 , Turkiye. Electronic address: atekdal@adiyaman.edu.tr. FAU - Unver Koca, Hacer AU - Unver Koca H AD - Department of Midwifery, Faculty of Health Sciences, Inonu University, Malatya, Turkiye. Electronic address: hacer.unver@inonu.edu.tr. LA - eng PT - Journal Article DEP - 20260806 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - Cross-Sectional Studies MH - *Breast Feeding/psychology/statistics & numerical data MH - *Stress, Psychological/psychology/complications MH - *Pregnant People/psychology MH - Psychometrics/instrumentation/methods MH - Surveys and Questionnaires MH - Turkey MH - *Perception MH - Parity MH - *Parturition/psychology MH - Adaptation, Psychological MH - Cognitive Flexibility OTO - NOTNLM OT - Breastfeeding OT - Prenatal stress OT - Primiparity OT - Psychological flexibility OT - Traumatic childbirth COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/14 23:37 MHDA- 2026/08/31 23:43 CRDT- 2026/08/14 18:05 PHST- 2026/02/15 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/31 23:43 [medline] PHST- 2026/08/14 23:37 [pubmed] PHST- 2026/08/14 18:05 [entrez] AID - S0266-6138(26)00241-X [pii] AID - 10.1016/j.midw.2026.104937 [doi] PST - ppublish SO - Midwifery. 2026 Nov;162:104937. doi: 10.1016/j.midw.2026.104937. Epub 2026 Aug 6. PMID- 42600329 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1873-1600 (Electronic) IS - 1466-853X (Linking) VI - 81 DP - 2026 Sep TI - Diagnostic accuracy of patient history and clinical examination to identify pathology in the lumbar spine of elite gymnasts with MRI as the reference standard. PG - 101970 LID - S1466-853X(26)00091-X [pii] LID - 10.1016/j.ptsp.2026.101970 [doi] AB - OBJECTIVE: To evaluate the diagnostic accuracy of patient history and physical examination for diagnosing common causes of low back pain in elite gymnasts, using MRI as the reference standard. DESIGN: Prospective cross-sectional study reported according to STARD guidelines. Index tests were acquired by an experienced musculoskeletal physiotherapist blinded to imaging. MRI scans were independently analysed by two specialist musculoskeletal radiologists. SETTING: MRI centre, Birmingham, UK. PARTICIPANTS: Non-probability consecutive total-population sample of elite gymnasts, regardless of low back pain status. MAIN OUTCOME MEASURES: Sensitivity and specificity of individual index tests and exploratory test clusters. RESULTS: Forty participants consented; 75% had abnormal MRI findings. Most specific findings were 'eased by flexion' and 'erector spinae hypertrophy' for degenerative disc disease, 'erector spinae hypertrophy', 'pain on flexion in standing', and 'pain on extension/left side flexion' for disc herniation, 'pain on flexion in standing' plus 'pain on extension/left side flexion' for pars oedema/spondylolysis; and 'eased by flexion' with the same cluster for spondylolisthesis. CONCLUSIONS: Highly specific index tests and exploratory clusters showed diagnostic accuracy for identifying gymnasts without degenerative disc disease, disc herniation, and pars oedema/spondylolysis. All gymnasts were recruited regardless of low back pain; these findings need to be considered cautiously when applied clinically. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Fawcett, Louise AU - Fawcett L AD - Head of Olympic Performance Support, UK Sports Institute, Lilleshall National Sports Centre, Nr Newport, Shropshire, TF10 9AT, UK; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK. Electronic address: LXF615@student.bham.ac.uk. FAU - Martin, James AU - Martin J AD - Biostatistics, Department of Applied Health Sciences, University of Birmingham, West Midlands, UK. FAU - James, Steven AU - James S AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK; Consultant Musculoskeletal Radiologist, Department of Radiology, Royal Orthopaedic Hospital, Birmingham, UK. FAU - Soundy, Andrew AU - Soundy A AD - Physiotherapy, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK. FAU - Heneghan, Nicola R AU - Heneghan NR AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK. FAU - Rushton, Alison AU - Rushton A AD - School of Physical Therapy, Western University, London, Canada; Centre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK. LA - eng PT - Journal Article DEP - 20260806 PL - England TA - Phys Ther Sport JT - Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine JID - 100940513 SB - IM MH - Humans MH - *Magnetic Resonance Imaging MH - Cross-Sectional Studies MH - Female MH - *Gymnastics/injuries MH - *Lumbar Vertebrae/pathology/diagnostic imaging MH - *Low Back Pain/diagnosis/etiology/diagnostic imaging MH - Prospective Studies MH - Male MH - *Physical Examination MH - Adolescent MH - Young Adult MH - Adult MH - Sensitivity and Specificity MH - *Medical History Taking MH - Reference Standards MH - Intervertebral Disc Degeneration/diagnosis OTO - NOTNLM OT - Diagnostic accuracy OT - Gymnastics OT - Low back pain OT - MRI COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Louise Fawcett reports financial support was provided by British Society of Skeletal Radiologists. Louise Fawcett reports financial support was provided by Musculoskeletal Association of Chartered Physiotherapists. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/14 23:37 MHDA- 2026/09/07 23:34 CRDT- 2026/08/14 18:04 PHST- 2026/05/07 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/08/14 23:37 [pubmed] PHST- 2026/08/14 18:04 [entrez] AID - S1466-853X(26)00091-X [pii] AID - 10.1016/j.ptsp.2026.101970 [doi] PST - ppublish SO - Phys Ther Sport. 2026 Sep;81:101970. doi: 10.1016/j.ptsp.2026.101970. Epub 2026 Aug 6. PMID- 42600070 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260816 IS - 2291-9279 (Print) IS - 2291-9279 (Electronic) VI - 14 DP - 2026 Aug 14 TI - Structured Virtual Reality Exergame Intervention in Adolescents With Mild Intellectual Disabilities: Pre-Post Pilot Study on Motor Proficiency and Reaction Time. PG - e95572 LID - 10.2196/95572 [doi] LID - e95572 AB - BACKGROUND: Adolescents with mild intellectual disabilities often exhibit deficits in motor proficiency and neurocognitive processing, which can limit their functional independence. Although virtual reality (VR) exergames provide a motivating platform for physical activity, objective data quantifying their impact on standardized motor scales remain scarce, particularly when implemented through structured pedagogical frameworks. Earlier research established the WISH (warm-up, imitation, settings, half-hour) and WON (warm-up, objective evaluation, no problem!) protocols to facilitate gameplay independence in this population. However, the extent to which this systematic approach translates into measurable clinical motor and reaction time gains requires further investigation. OBJECTIVE: This study evaluated the effectiveness of a 16-session structured VR exergame intervention, using the WISH and WON protocols, in enhancing motor proficiency and shortening simple reaction time among adolescents with mild intellectual disability. METHODS: A multisession, single-group pretest and posttest pilot design was used. A convenience sample of 8 adolescents (3 males, 5 females; mean age 17.63, SD 1.77, range 15-20 years) was recruited from a special school complex in Poland. The intervention was conducted over an 8-month period (October 2023 to May 2024), consisting of 16 sessions conducted once every 2 weeks. The rhythmic fitness game "OhShape!" (Odders Lab) was played on the Meta Quest 2 system. Motor proficiency was assessed with the Bruininks-Oseretsky Test of Motor Proficiency short form, and simple reaction time to visual and auditory stimuli was measured using a standardized Alfa-Electronics meter. Statistical analysis was performed using the Wilcoxon signed-rank test (alpha=.05). RESULTS: Total Bruininks-Oseretsky Test of Motor Proficiency scores significantly improved from a baseline mean of 69.25 (SD 6.80; 95% CI 63.56-74.94) to 80.50 (SD 5.50; 95% CI 75.90-85.10) at the posttest (P=.01; r=0.74). Based on the standardized 5-point proficiency scale, the group mean rose from 1.88 (SD .64; 95% CI 1.34-2.42) at baseline to 2.88 (SD .35; 95% CI 2.59-3.17) postintervention (P=.008; r=0.89). Furthermore, the mean simple reaction time decreased from 426.50 (SD 52.3; 95% CI 382.78-470.22) ms to 392.10 (SD 38.4; 95% CI 359.98-424.22) ms at the final assessment (P=.02; r=0.72). CONCLUSIONS: This pilot study suggests structured VR exergaming may address motor deficits in adolescents with mild intellectual disability. Promoting autonomy via protocols was associated with measurable motor gains within this cohort. Although the absence of a control group limits causal claims, immersive VR may offer a supportive tool for neuro-motor adaptations in special education, warranting validation in larger controlled trials. CI - (c) Julia Ciazynska, Agnieszka Kazimiera Rudowicz, Aneta Worska, Janusz Maciaszek. Originally published in JMIR Serious Games (https://games.jmir.org). FAU - Ciazynska, Julia AU - Ciazynska J AUID- ORCID: 0000-0001-9065-9164 AD - Department of Physical Activity and Health Promotion Science, Poznan University of Physical Education, Krolowej Jadwigi 27/39, Poznan, Poland, 48 (61) 835 50 07. FAU - Rudowicz, Agnieszka Kazimiera AU - Rudowicz AK AUID- ORCID: 0009-0002-3009-0046 AD - Special School Complex No. 102, Poznan, Poland. FAU - Worska, Aneta AU - Worska A AUID- ORCID: 0000-0003-1624-5267 AD - Department of Physical Activity and Health Promotion Science, Poznan University of Physical Education, Krolowej Jadwigi 27/39, Poznan, Poland, 48 (61) 835 50 07. FAU - Maciaszek, Janusz AU - Maciaszek J AUID- ORCID: 0000-0001-8425-5921 AD - Department of Physical Activity and Health Promotion Science, Poznan University of Physical Education, Krolowej Jadwigi 27/39, Poznan, Poland, 48 (61) 835 50 07. LA - eng PT - Journal Article DEP - 20260814 PL - Canada TA - JMIR Serious Games JT - JMIR serious games JID - 101645255 PMC - PMC13475785 OTO - NOTNLM OT - active video game OT - bilateral coordination OT - exergame OT - gross motor movements OT - health promotion OT - intellectual disabilities OT - physical activity OT - physical education OT - postural stability OT - virtual reality COIS- Conflicts of Interest: None declared. EDAT- 2026/08/14 17:39 MHDA- 2026/08/14 17:40 PMCR- 2026/08/14 CRDT- 2026/08/14 15:03 PHST- 2026/03/17 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/14 17:40 [medline] PHST- 2026/08/14 17:39 [pubmed] PHST- 2026/08/14 15:03 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - v14i1e95572 [pii] AID - 95572 [pii] AID - 10.2196/95572 [doi] PST - epublish SO - JMIR Serious Games. 2026 Aug 14;14:e95572. doi: 10.2196/95572. PMID- 42599780 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260831 IS - 1680-0745 (Electronic) IS - 1015-9657 (Linking) VI - 37 IP - 3 DP - 2026 Jul 31 TI - Body mass index predicts ventricular repolarisation in obese children: differential effects across obesity levels. PG - 282-292 LID - 10.5830/CVJA-2026-029 [doi] AB - BACKGROUND: Childhood obesity is associated with cardiac electrical remodelling, yet the relationship between body mass index (BMI) and ventricular repolarisation (VR) heterogeneity remains incompletely characterised in paediatric obesity. METHODS: This prospective observational comparative study enrolled 184 children (112 obese, 72 normal-weight; age 8-17 years). Electrocardiographic analysis included traditional (QT, QTc, JT) and novel VR parameters (Tp-e interval, Tp-e/QT, Tp-e/QTc ratios). Multiple linear regression and receiver operating characteristic (ROC) analyses identified independent predictors and clinically applicable thresholds. RESULTS: Obese children demonstrated significantly prolonged Tp-e intervals (87.83 +/- 12.35 vs. 80.10 +/- 16.80 ms, p = 0.002) and elevated Tp-e/QTcB ratios (0.211 +/- 0.028 vs. 0.192 +/- 0.034, p < 0.001). BMI emerged as the independent predictor of VR heterogeneity (beta = 0.308, p < 0.001), after adjustment for insulin resistance, metabolic parameters, and echocardiographic findings. Regression analyses revealed differences in the BMI-repolarisation relationship: strong associations in normal-weight children (beta = 0.353, p = 0.003), disappearing in established obesity (beta = -0.041, p = 0.699), and a significant BMI x group interaction was observed (beta = -2.079, p = 0.001). ROC analysis identified BMI >/= 23.1 kg/m(2) as the optimal threshold for abnormal repolarisation (AUC = 0.682, sensitivity 76.1%, specificity 50.0%, p < 0.001). CONCLUSION: Childhood obesity is associated with VR abnormalities independently of metabolic dysfunction and structural cardiac changes. This study suggests that repolarisation abnormalities occur in the early stages of obesity and through different pathophysiological mechanisms. The defined BMI threshold provides a clinically applicable tool for early risk stratification, highlighting the critical importance of intervention before obesity becomes established. FAU - Karayakali, Metin AU - Karayakali M AD - Department of Cardiology, Tokat Gaziosmanpasa University, Tokat, Turkey. Email: drmk5170@gmail.com. FAU - Karaman, Kayihan AU - Karaman K AD - Department of Cardiology, Tokat Gaziosmanpasa University, Tokat, Turkey. FAU - Kasap, Tuba AU - Kasap T AD - Department of Pediatric Clinics, Tokat Gaziosmanpasa University, Tokat, Turkey. FAU - Yilmaz, Volkan AU - Yilmaz V AD - Department of Cardiology, Tokat Gaziosmanpasa University, Tokat, Turkey. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260731 PL - South Africa TA - Cardiovasc J Afr JT - Cardiovascular journal of Africa JID - 101313864 SB - IM MH - Humans MH - Child MH - *Body Mass Index MH - Male MH - Female MH - Prospective Studies MH - Adolescent MH - *Pediatric Obesity/diagnosis/physiopathology/complications MH - Electrocardiography MH - *Action Potentials MH - Predictive Value of Tests MH - *Arrhythmias, Cardiac/physiopathology/etiology/diagnosis MH - *Heart Rate MH - Age Factors MH - Risk Factors MH - *Heart Conduction System/physiopathology MH - Adiposity MH - *Ventricular Remodeling MH - Risk Assessment OTO - NOTNLM OT - arrhythmia OT - body mass index OT - electrocardiogram OT - repolarisation EDAT- 2026/08/14 17:39 MHDA- 2026/08/14 17:40 CRDT- 2026/08/14 12:22 PHST- 2025/12/14 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/08/14 17:40 [medline] PHST- 2026/08/14 17:39 [pubmed] PHST- 2026/08/14 12:22 [entrez] AID - 10.5830/CVJA-2026-029 [doi] PST - ppublish SO - Cardiovasc J Afr. 2026 Jul 31;37(3):282-292. doi: 10.5830/CVJA-2026-029. Epub 2026 Jul 31. PMID- 42598624 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260926 IS - 0976-5662 (Print) IS - 2213-3445 (Electronic) IS - 0976-5662 (Linking) VI - 82 DP - 2026 Nov TI - Direct anterior approach for open correction of Slipped Capital Femoral Epiphysiolysis: surgical technique and clinical outcome. PG - 103572 LID - 10.1016/j.jcot.2026.103572 [doi] LID - 103572 AB - BACKGROUND: Slipped Capital Femoral Epiphysis (SCFE) is an idiopathic hip disorder in adolescents. With or without surgery, avascular necrosis (AVN) is the most dangerous complication. For open reduction and internal fixation, the modified Dunn procedure is considered the gold standard. This study presents an open epiphyseal realignment through the Hueter-interval and reports on (1) surgical technique of direct anterior approach (DAA) based surgical realignment, (2) radiographic correction of biomechanics, and (3) AVN-incidence after surgery. METHODS: A single-center retrospective case series was conducted including all patients who underwent open realignment for SCFE via the direct anterior approach between January 2014 and January 2025. Pre- and postoperative Southwick and alpha angles were measured by two independent observers. Complications, including avascular necrosis, chondrolysis, and degenerative changes, were assessed at final follow-up. Descriptive statistics were used. Interobserver agreement of radiographic measurements was assessed using the intraclass correlation coefficient (ICC). RESULTS: Twelve patients (13 hips; 9 boys and 3 girls) were included. Median age and BMI were respectively 12.9 years old (IQR 12.2-13.7) and 23.1 kg/m(2) (IQR 19.9-29.5) kg/m(2). One patient showed bilateral involvement. Median preoperative AP - and lateral Southwick angle were respectively 117.5 (IQR 95.8-137.3) and 59.6 (IQR 35.1-71.8) degrees. After open realignment, median postoperative AP - and lateral Southwick angles were respectively 139.5 (IQR 135.0-143.3) and 14.7 (IQR 11.3-20.9). Thus, a correction of the lateral Southwick angle of 31.2 (IQR 17.4-54.2) was achieved. Follow-up was 6.0 years (IQR 2.4-8.3) and none of the patients developed AVN. Median Alpha-angle on Dunn view at final follow-up was 44.5 (IQR 42.8-68.1). CONCLUSION: The DAA described in this series, can be considered a reproducible technique for an open realignment of displaced SCFE. None of the cases had an AVN and the approach does not appear to limit correction potential. LEVEL OF EVIDENCE: Level 4 Therapeutic study. CI - (c) 2026 The Authors. FAU - Vandeputte, Frans-Jozef AU - Vandeputte FJ AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. AD - European Hip Center, Boskant 18, 2260, Westerlo, Belgium. AD - Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium. FAU - Clarebout, Siebe AU - Clarebout S AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. FAU - Sergooris, Abner AU - Sergooris A AD - European Hip Center, Boskant 18, 2260, Westerlo, Belgium. AD - REVAL, Rehabilitation Research, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium. FAU - Gevers, Mathieu AU - Gevers M AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. FAU - Van Praet, Frank AU - Van Praet F AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. FAU - Corten, Kristoff AU - Corten K AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. AD - European Hip Center, Boskant 18, 2260, Westerlo, Belgium. AD - REVAL, Rehabilitation Research, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium. LA - eng PT - Journal Article DEP - 20260720 PL - India TA - J Clin Orthop Trauma JT - Journal of clinical orthopaedics and trauma JID - 101559469 PMC - PMC13472028 OTO - NOTNLM OT - Direct anterior approach OT - SCFE OT - Slipped capital femoral Epiphyses COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/07/20 CRDT- 2026/08/14 08:03 PHST- 2026/04/15 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 08:03 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - S0976-5662(26)00240-7 [pii] AID - 103572 [pii] AID - 10.1016/j.jcot.2026.103572 [doi] PST - epublish SO - J Clin Orthop Trauma. 2026 Jul 20;82:103572. doi: 10.1016/j.jcot.2026.103572. eCollection 2026 Nov. PMID- 42598598 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260817 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Effects of physical activity distribution patterns on basketball skill acquisition and physical exercise self-efficacy among Chinese male university students: a randomised controlled trial. PG - e21459 LID - 10.7717/peerj.21459 [doi] LID - e21459 AB - BACKGROUND: As an open-skills sport, basketball not only enhances university students' physical fitness and specialised techniques but also influences their technical learning efficiency and exercise self-efficacy through patterns of physical activity distribution. However, empirical research on the mechanisms underlying the effects of physical activity distribution patterns on basketball technical performance and self-efficacy remains limited. OBJECTIVE: This study aims to investigate the impact of two distinct physical activity patterns (massed vs. regularly distributed) on specialised basketball skill acquisition and exercise self-efficacy among Chinese male university students. METHOD: A randomised controlled trial design was employed, enrolling 105 male university students aged 18-25 years. The participants were randomly assigned to either a massed training group or a regularly distributed training group. Both interventions lasted 8 weeks, followed by a 2-month follow-up period. Training volume and intensity were maintained at equivalent levels, differing solely in the distribution of practice sessions. Basketball skill acquisition was assessed through shooting accuracy, dribbling agility, and passing precision, whereas psychological efficacy was measured via the Revised Self-Efficacy Scale for Physical Exercise. Generalised estimating equation (GEE) and simple effects analyses were employed to examine between-group and within-group differences, controlling for potential confounding factors. RESULTS: The findings indicate that the regularly distributed training group demonstrated significantly greater improvements than did the massed training group in shooting (odds ratio (OR) = 2.316, P < 0.001), passing (OR = 1.608, P < 0.001), and self-efficacy (OR = 2.691, P = 0.001), with partial effects persisting two months post-intervention. Both groups demonstrated improvements in dribbling performance, although the differences between groups were not statistically significant. CONCLUSION: A regularly distributed physical activity pattern has greater advantages in promoting basketball-specific skills (particularly shooting and passing) and physical exercise self-efficacy. This suggests that basketball training programmes should prioritise optimising practice distribution to increase skill acquisition quality and sustain long-term exercise motivation. Future research may extend to different gender and age groups while incorporating game performance metrics to further validate the efficacy of distributed practice. CI - (c)2026 Liu et al. FAU - Liu, Zhuoxiao AU - Liu Z AD - Strength and Conditioning Training College, Beijing Sports University, Haidian, Beijing, China. AD - School of Physical Education, Shanghai University of Sport, Yangpu, Shanghai, China. FAU - Zhou, Chengyu AU - Zhou C AD - Strength and Conditioning Training College, Beijing Sports University, Haidian, Beijing, China. AD - School of Physical Education, Shanghai University of Sport, Yangpu, Shanghai, China. FAU - Zeng, Zhuo AU - Zeng Z AD - Strength and Conditioning Training College, Beijing Sports University, Haidian, Beijing, China. FAU - Yang, Huaibo AU - Yang H AD - Department of Physical Education, Hongshan College of Nanjing University of Finance and Economics, Nanjing, Jiangsu, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260810 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 RN - Chinese people SB - IM MH - Humans MH - Male MH - *Basketball/psychology MH - *Self Efficacy MH - Young Adult MH - Adult MH - Adolescent MH - *Exercise/psychology MH - Universities MH - *Students/psychology MH - China MH - *Athletic Performance MH - East Asian People PMC - PMC13471745 OTO - NOTNLM OT - Basketball OT - Distributed practice OT - Physical activity patterns OT - Physical exercise self-efficacy OT - Technical performance COIS- The authors declare there are no competing interests. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/08/10 CRDT- 2026/08/14 08:02 PHST- 2025/11/24 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 08:02 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 21459 [pii] AID - 10.7717/peerj.21459 [doi] PST - epublish SO - PeerJ. 2026 Aug 10;14:e21459. doi: 10.7717/peerj.21459. eCollection 2026. PMID- 42597527 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260815 IS - 2296-875X (Print) IS - 2296-875X (Electronic) IS - 2296-875X (Linking) VI - 13 DP - 2026 TI - Development of an automated machine learning-based risk prediction and decision support system for postoperative cubitus varus complicating pediatric lateral humeral condyle fracture. PG - 1836372 LID - 10.3389/fsurg.2026.1836372 [doi] LID - 1836372 AB - PURPOSE: Postoperative cubitus varus is a disabling complication of pediatric lateral humeral condyle fractures that impairs long-term elbow function. This study aimed to develop and validate the first Improved LangEvin Equation-based Evolutionary (ILEE) automated machine learning (AutoML) model and visual decision support system for preoperative prediction of this complication, to enable personalized risk stratification and targeted intervention. METHODS: We conducted a retrospective cohort study of 330 children with lateral humeral condyle fractures treated between January 2005 and June 2022. An ILEE-optimized AutoML model was constructed and compared with the original LEE algorithm and 6 conventional machine learning models. Model performance was evaluated using area under the receiver operating characteristic curve (ROC-AUC), accuracy, sensitivity, and specificity. Key predictors were identified and interpreted via SHapley Additive exPlanations (SHAP) analysis, and a clinical decision support system was developed using MATLAB App Designer. RESULTS: The ILEE algorithm outperformed all comparators in optimization stability and convergence speed. The AutoML model identified five key features for predicting cubitus varus and exhibited better prediction calibration performance compared to other models (ROC-AUC = 0.9557). SHAP analysis ranked the importance of these features as follows: obesity degree, preoperative timing, internal fixation time, fracture type, and external fixation time. The decision support system can generate real-time risk levels, predicted probabilities, and personalized clinical recommendations within 1 s. CONCLUSION: This study establishes the first ILEE-based AutoML model for predicting postoperative cubitus varus in pediatric lateral humeral condyle fractures, demonstrating competitive predictive performance. The user-friendly visual system enables rapid preoperative risk assessment, assisting clinicians in identify high-risk patients, optimize treatment plans, and potentially improving pediatric orthopedic outcomes. CI - (c) 2026 Wan, Deng, Yuan, Zhang, Li, Cai and Wang. FAU - Wan, Yu AU - Wan Y AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Deng, Kun AU - Deng K AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yuan, Yang AU - Yuan Y AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Li AU - Zhang L AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Li, Cong AU - Li C AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Cai, Haoqi AU - Cai H AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Yufeng AU - Wang Y AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. LA - eng PT - Journal Article DEP - 20260730 PL - Switzerland TA - Front Surg JT - Frontiers in surgery JID - 101645127 PMC - PMC13469642 OTO - NOTNLM OT - automated machine learning OT - clinical decision support system OT - cubitus varus OT - improved langEvin equation-based evolutionary OT - lateral humeral condyle fracture COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/07/30 CRDT- 2026/08/14 06:27 PHST- 2026/03/22 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 06:27 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - 10.3389/fsurg.2026.1836372 [doi] PST - epublish SO - Front Surg. 2026 Jul 30;13:1836372. doi: 10.3389/fsurg.2026.1836372. eCollection 2026. PMID- 42597386 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260815 IS - 2296-875X (Print) IS - 2296-875X (Electronic) IS - 2296-875X (Linking) VI - 13 DP - 2026 TI - Do multidisciplinary ERAS protocols improve flap reconstruction outcomes? A structured review of efficacy, implementation challenges, and specialty-driven adaptations. PG - 1897143 LID - 10.3389/fsurg.2026.1897143 [doi] LID - 1897143 AB - BACKGROUND: Enhanced Recovery After Surgery (ERAS) pathways are increasingly used in reconstructive plastic surgery, but flap reconstruction presents specific challenges, including dependence on stable microvascular perfusion, procedure-specific immobilization, donor-site morbidity, and heterogeneous anatomic indications. Because available studies differ substantially in surgical setting, flap type, ERAS bundle composition, comparator care, and outcome reporting, this article is presented as a structured narrative synthesis rather than a de novo meta-analysis. METHODS: PubMed, Embase, Web of Science, and Google Scholar were searched for studies and reviews published from 1997 to 14 June 2026 that addressed ERAS, fast-track, or accelerated recovery pathways in flap reconstruction or closely related reconstructive plastic surgery settings. The review question was defined using PICOS: adult or pediatric patients undergoing flap-based reconstruction; perioperative ERAS or accelerated recovery bundles; conventional perioperative care or pre-implementation practice; clinical, recovery, safety, and patient-centered outcomes; and randomized, prospective, retrospective, implementation, and systematic-review designs. Because ERAS bundles, flap types, and outcome definitions were clinically heterogeneous, no formal quantitative pooling was performed. RESULTS: Across breast reconstruction, head and neck free-flap reconstruction, perineal or pelvic reconstruction, lower-limb reconstruction, and selected flap-based wound procedures, ERAS pathways were most consistently associated with shorter hospital stay, earlier mobilization or feeding, and reduced opioid exposure. Safety outcomes, including flap compromise, readmission, and return to theatre, were generally not worse in the cited studies, but certainty is limited by observational designs, single-center implementation studies, variable adherence, and inconsistent reporting. The components most relevant to flap surgery are preoperative optimization, multimodal analgesia, goal-directed fluid therapy, protocolized flap monitoring, early but protected mobilization, nutrition, and explicit nursing-clinician coordination. CONCLUSIONS: ERAS appears feasible and potentially beneficial in flap reconstruction when adapted to flap type, anatomic site, comorbidity burden, and reconstructive goals. The current evidence supports cautious implementation and local auditing rather than universal adoption of a single protocol. Future research should use plastic surgery-specific ERAS definitions, report study-level outcomes transparently, separate reconstructive from aesthetic indications where clinically appropriate, and prioritize long-term function, patient-reported outcomes, cost, and flap-specific safety endpoints. CI - (c) 2026 Xiao, Su and Zhang. FAU - Xiao, Meihui AU - Xiao M AD - Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. FAU - Su, Ximei AU - Su X AD - Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. FAU - Zhang, Ting AU - Zhang T AD - Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260730 PL - Switzerland TA - Front Surg JT - Frontiers in surgery JID - 101645127 PMC - PMC13469098 OTO - NOTNLM OT - ERAS OT - enhanced recovery after surgery OT - flap reconstruction OT - multidisciplinary care OT - reconstructive plastic surgery COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/07/30 CRDT- 2026/08/14 06:07 PHST- 2026/06/01 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 06:07 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - 10.3389/fsurg.2026.1897143 [doi] PST - epublish SO - Front Surg. 2026 Jul 30;13:1897143. doi: 10.3389/fsurg.2026.1897143. eCollection 2026. PMID- 42597189 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260815 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Microbiota-gut-brain axis in cerebral palsy: from mechanisms to interventions. PG - 1911417 LID - 10.3389/fmed.2026.1911417 [doi] LID - 1911417 AB - Cerebral palsy (CP) is the most common cause of chronic motor disability in childhood and arises from non-progressive injury to the developing brain. Despite the static nature of the primary lesion, children with CP frequently experience evolving gastrointestinal, nutritional, inflammatory, sleep, cognitive, and seizure-related comorbidities that substantially influence functional recovery and caregiver burden. The microbiota-gut-brain axis (MGBA) provides a biologically plausible framework linking these multisystem manifestations. Emerging evidence suggests that children with CP may exhibit reduced gut microbial diversity, depletion of short-chain fatty acid (SCFA)-producing taxa, enrichment of opportunistic bacteria, and microbiome remodeling related to diet, constipation, antiepileptic drug exposure, oral inflammation, and care patterns. Dysbiosis may interact with CP through epithelial barrier disruption, lipopolysaccharide translocation, systemic immune activation, altered tryptophan-kynurenine metabolism, abnormal bile acid and SCFA signaling, vagal and enteric nervous system pathways, hypothalamic-pituitary-adrenal axis dysregulation, and microglial priming. These mechanisms may create a self-reinforcing cycle in which early brain injury promotes gut dysfunction, gut dysfunction reshapes the microbiome, and dysbiotic immune-metabolic signals further amplify symptom burden. Current interventions, including nutritional optimization, constipation protocols, dietary fiber, probiotics, prebiotics, synbiotics, oral health management, and family-centered care, show promise for improving bowel symptoms and selected microbial or inflammatory indices. However, most clinical studies remain small, short-term, and focused on constipation rather than long-term neurodevelopmental outcomes. All CP-specific human evidence currently demonstrates association rather than causation; no study has established that dysbiosis initiates CP or causally drives its neurological phenotype. Accordingly, mechanistic pathways are presented as testable hypotheses, not validated causal mechanisms in CP. This review synthesizes current evidence on the MGBA in CP, outlines mechanistic pathways, evaluates therapeutic opportunities, and proposes future directions for biomarker-driven and stratified intervention trials. CI - Copyright (c) 2026 Xie, Bai, Xu and Luan. FAU - Xie, Fei AU - Xie F AD - Department of Neurosurgery, The Seventh Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. FAU - Bai, Chao AU - Bai C AD - Cerebral Palsy Center in Neurosurgery, Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. FAU - Xu, Jian AU - Xu J AD - Department of Neurosurgery, The Seventh Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. FAU - Luan, Xinping AU - Luan X AD - Cerebral Palsy Center in Neurosurgery, Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. LA - eng PT - Journal Article PT - Review DEP - 20260730 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13467827 OTO - NOTNLM OT - cerebral palsy OT - constipation OT - gut microbiota OT - microbiota-gut-brain axis OT - neuroinflammation OT - nutritional intervention OT - probiotics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/07/30 CRDT- 2026/08/14 05:32 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 05:32 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - 10.3389/fmed.2026.1911417 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Jul 30;13:1911417. doi: 10.3389/fmed.2026.1911417. eCollection 2026. PMID- 42597104 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260816 IS - 2997-9684 (Electronic) IS - 2997-9684 (Linking) VI - 1 IP - 5 DP - 2025 Sep TI - Maternal postpartum blood pressure screening at newborn visits and its impact on postpartum care utilization. PG - e70111 LID - 10.1002/pmf2.70111 [doi] LID - e70111 AB - BACKGROUND: To assess the impact of a maternal cardiovascular (CV) and blood pressure (BP) screening and standardized referral protocol at newborn visits on care utilization in the first 12 weeks postpartum. METHODS: This prospective quality improvement initiative obtained maternal vital signs and CV symptoms at a pediatric academic practice. Elevated BP (>/=140/90 mmHg) triggered enrollment into a remote BP management program, on-call Maternal-Fetal Medicine or Cardiology physician consultation, and/or emergency department (ED) referral. Unmatched control group were postpartum individuals of newborns seen on non-screening days in the same clinic. Outcomes included postpartum visit attendance, ED visits, readmissions, new postpartum hypertension (HTN) diagnosis, remote BP monitoring program enrollment, and postpartum antihypertensive initiation. Multivariable logistic regression was used to calculate odds ratios for postpartum care utilization outcomes and adjusted for demographic differences between groups (parity, BMI, gestational age, smoking) and other covariates related to postpartum care utilization (age, insurance, preexisting HTN). Interaction analyses tested effect modification by preexisting HTN status, with predictive margins calculated when significant using chi-square tests. RESULTS: We included 132 screened individuals and 248 controls (77.9% non-White, 76.3% publicly insured). Among those screened, 34.1% (n = 45) had elevated BP, with 38.7% (n = 17) having no prior HTN diagnosis. Among screened participants with known HTN (n = 45), 62.2% (n = 28) had elevated BP at screening. The intervention group had significantly higher rates of newly diagnosed postpartum HTN (20.7% vs. 8.2%, p < 0.01). After adjustment, the intervention had no effect on postpartum visit attendance (OR 1.05, 95% CI 0.62-1.78), but reduced the odds of ED visits (OR 0.52, 95% CI 0.29-0.95) and readmissions (OR 0.31, 95% CI 0.11-0.95). For those with preexisting HTN, acute care utilization was similar between groups (ED visits-chi(2) = 0.56, p = 0.45; readmissions-chi(2) = 0.18, p = 0.66). CONCLUSION: This intervention detected more postpartum HTN while being associated with decreased odds of ED visits and readmissions. Acute care usage was similar for those with existing HTN, despite high rates of uncontrolled HTN at screening. This suggests maternal BP screening at newborn visits paired with remote BP monitoring may improve our postpartum patient outreach and be more feasible than traditional care while reducing acute care needs. CI - (c) 2025 The Author(s). Pregnancy published by Wiley Periodicals LLC on behalf of Society for Maternal-Fetal Medicine. FAU - Anderson, Paige M AU - Anderson PM AD - University of Pittsburgh Medical Center Magee-Womens Hospital Pittsburgh Pennsylvania USA. AD - Present address: Department of Obstetrics and Gynecology University of North Carolina Chapel Hill School of Medicine Chapel Hill North Carolina USA. FAU - Krauss, Amanda AU - Krauss A AD - University of Pittsburgh Medical Center Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA. AD - Present address: University of Michigan Congenital Heart Center Ann Arbor Michigan USA. FAU - Blake, Brianna AU - Blake B AD - University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA. FAU - Kar, Ronit AU - Kar R AD - University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA. FAU - Pantalone, Julia AU - Pantalone J AD - University of Pittsburgh Medical Center Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA. FAU - Phillips, Adriana AU - Phillips A AD - University of Pittsburgh Medical Center Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA. FAU - Muniz, Gysella B AU - Muniz GB AD - University of Pittsburgh Medical Center Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA. FAU - Saladino, Jacqueline AU - Saladino J AD - University of Pittsburgh Medical Center Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA. FAU - Countouris, Malamo E AU - Countouris ME AD - Magee-Womens Research Institute University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA. AD - University of Pittsburgh Medical Center Heart and Vascular Institute Pittsburgh Pennsylvania USA. FAU - Hauspurg, Alisse AU - Hauspurg A AD - University of Pittsburgh Medical Center Magee-Womens Hospital Pittsburgh Pennsylvania USA. AD - Magee-Womens Research Institute University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA. AD - Present address: Women & Infants Hospital of Rhode Island Alpert Medical School of Brown University Providence Rhode Island USA. LA - eng GR - K12 HD043441/HD/NICHD NIH HHS/United States GR - K23 HL168356/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20250916 PL - United States TA - Pregnancy (Hoboken) JT - Pregnancy (Hoboken, N.J.) JID - 9918994890806676 PMC - PMC13344582 OTO - NOTNLM OT - blood pressure OT - hypertension OT - maternal-infant care OT - postpartum OT - pregnancy OT - quality improvement OT - well-child care COIS- The authors declare no conflicts of interest. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2025/09/16 CRDT- 2026/08/14 05:24 PHST- 2025/05/08 00:00 [received] PHST- 2025/08/14 00:00 [revised] PHST- 2025/09/02 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 05:24 [entrez] PHST- 2025/09/16 00:00 [pmc-release] AID - PMF270111 [pii] AID - 10.1002/pmf2.70111 [doi] PST - epublish SO - Pregnancy (Hoboken). 2025 Sep 16;1(5):e70111. doi: 10.1002/pmf2.70111. eCollection 2025 Sep. PMID- 42597048 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260815 IS - 2997-9684 (Electronic) IS - 2997-9684 (Linking) VI - 2 IP - 1 DP - 2026 Jan TI - Diagnostic accuracy of the Hunger Vital Sign screener for food insecurity in an obstetric population. PG - e70238 LID - 10.1002/pmf2.70238 [doi] LID - e70238 AB - INTRODUCTION: The Hunger Vital Sign (HVS) is a two-item, validated food insecurity screener recommended by the American Academy of Pediatrics. Given its brevity, HVS could be useful in assessing food insecurity in pregnant populations, for whom high-quality nutrition and food access is essential. However, the HVS has not been evaluated in obstetric settings. Thus, we aimed to evaluate the performance of the HVS compared to the gold standard, the 18-item US Household Food Security Survey Module (HFSSM) among low-income, urban pregnant people. METHODS: We conducted a prospective study at a multi-hospital tertiary health system (September 2023 to April 2024) in the United States. English- or Spanish-speaking individuals from zip codes in which >/=10% of households were under the federal poverty line or who had publicly funded antenatal care completed a 20-min self-administered survey, which included the HFSSM and HVS. Food insecurity was defined as marginal, low, or very low food insecurity on the HFSSM; the prevalence of food insecurity was assessed and evaluated by participant characteristics. A positive screen on the HVS was defined as a "often true" or "sometimes true" to either item. Descriptive statistics were performed to characterize the performance of the HVS compared to the HFSSM. RESULTS: Of 713 potentially eligible participants based on medical record review, 192 (27%) completed an eligibility screener and were found to be eligible. Of these, 171 (89%) completed the survey. Nearly half (41%) of participants (n = 70; of whom 74% received publicly funded care) screened positive for food insecurity on the HFSSM. HVS sensitivity was 83%, while specificity was 96%. The positive predictive value of the HVS was 94% and negative predictive value was 89%. CONCLUSION: The two-item HVS had relatively high accuracy for detecting food insecurity in this low-income, urban obstetric population. Incorporating this brief screener into prenatal care may enable efficient, clinically useful food insecurity detection and intervention to address this need. CI - (c) 2026 The Author(s). Pregnancy published by Wiley Periodicals LLC on behalf of Society for Maternal-Fetal Medicine. FAU - Merchant, Tazim AU - Merchant T AUID- ORCID: 0000-0002-9161-9751 AD - Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago Illinois USA. AD - Department of Obstetrics and Gynecology Mayo Clinic Rochester Minnesota USA. FAU - McLean, Samantha AU - McLean S AD - Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago Illinois USA. FAU - Ludke, Meghan AU - Ludke M AD - Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago Illinois USA. FAU - Cheung, Ying AU - Cheung Y AD - Division of Biostatistics Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA. FAU - Mathur, Priyanka AU - Mathur P AD - Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago Illinois USA. AD - Department of Obstetrics and Gynecology Brigham and Women's Hospital and Massachusetts General Hospital Boston Massachusetts USA. FAU - Raucher, Sydney AU - Raucher S AD - Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago Illinois USA. FAU - Niznik, Charlotte AU - Niznik C AD - Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago Illinois USA. FAU - Feinglass, Joe AU - Feinglass J AUID- ORCID: 0000-0002-3665-8897 AD - Division of General Internal Medicine, Department of Medicine Northwestern Feinberg School of Medicine Chicago Illinois USA. FAU - Yee, Lynn M AU - Yee LM AUID- ORCID: 0000-0002-6274-0544 AD - Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago Illinois USA. LA - eng PT - Journal Article DEP - 20260124 PL - United States TA - Pregnancy (Hoboken) JT - Pregnancy (Hoboken, N.J.) JID - 9918994890806676 PMC - PMC13344497 OTO - NOTNLM OT - food access OT - food insecurity OT - hunger vital sign (HVS) OT - social determinant of health COIS- The authors declare no conflicts of interest. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/01/24 CRDT- 2026/08/14 05:21 PHST- 2025/08/11 00:00 [received] PHST- 2025/12/26 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 05:21 [entrez] PHST- 2026/01/24 00:00 [pmc-release] AID - PMF270238 [pii] AID - 10.1002/pmf2.70238 [doi] PST - epublish SO - Pregnancy (Hoboken). 2026 Jan 24;2(1):e70238. doi: 10.1002/pmf2.70238. eCollection 2026 Jan. PMID- 42596884 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260816 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 16 DP - 2026 Aug 14 TI - DNA methylation informs adult cardiovascular risk and prevention for low birthweight individuals. PG - 04242 LID - 10.7189/jogh.16.04242 [doi] LID - 04242 AB - BACKGROUND: Barker's hypothesis posits that adverse in utero exposures, often reflected by low birthweight, increase adult cardiovascular disease (CVD) risk. However, underlying mechanisms remain unclear; identifying potentially causal mediators is crucial for developing effective interventions. Emerging research suggests epigenetic modifications may influence CVD traits from early life. We aimed to identify DNA methylation (DNAm) signatures that mediate birthweight and CVD traits and to establish their biological relevance across three developmental time points using multi-omics integration. METHODS: We identified DNAm mediators using epigenetic Mendelian randomisation (MR). The exposures were 261 birthweight-associated CpG sites (BW-CpGs) from epigenome-wide association studies, instrumented by cis-methylation quantitative trait loci (cis-mQTLs) in European-ancestry participants from the Accessible Resource for Integrative Epigenomic Studies measured at three developmental time points: birth (mean gestational age = 40 weeks), childhood (mean age = 7.49 years), and adolescence (mean age = 17.14 years). The outcomes included adult cardiovascular events and lipid traits from genome-wide association studies (n = 98,048-547,261). Sensitivity analyses included colocalisation, Steiger's test, Cochran's Q, and pleiotropy-robust methods. We interrogated DNAm persisting across development using omics datasets. RESULTS: Using cis-mQTLs measured at birth, we found 230 associations between 216 BW-CpGs and CVD traits, including coronary artery disease, hypertension, stroke, cholesterol, and triglycerides (false discovery rate-corrected P < 0.05), with effect size directions consistent with Barker's hypothesis. A total of 42 associations were robust following sensitivity analyses. Persistent DNAm changes across development were observed at ASGR1 and KDM2B. Multi-omics interrogation prioritised a promising therapeutic candidate (ASGR1). CONCLUSIONS: Although Barker's hypothesis is well-established, this is the first study to explore its causal pathway using a rigorous, multi-time-point epigenetic MR framework with multi-omic integration. This represents a major advancement over previous observational and DNAm studies. The Barker-consistent hypothesis-free discovery approach identified novel and known candidate genes that, with future validation, may serve as therapeutic targets, identify high-risk individuals, and support clinical trial recruitment. CI - (c) 2026 The Authors. FAU - Tang, John Yen AU - Tang JY FAU - Ng, Nicole Ying Ting AU - Ng NYT FAU - Kwok, Alice Wing Sze AU - Kwok AWS FAU - Mak, Christopher Chun Yu AU - Mak CCY FAU - Cheung, Yiu-Fai AU - Cheung YF FAU - Chung, Brian Hon Yin AU - Chung BHY LA - eng PT - Journal Article DEP - 20260814 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - *DNA Methylation MH - Female MH - *Cardiovascular Diseases/genetics/prevention & control/epidemiology MH - Genome-Wide Association Study MH - *Infant, Low Birth Weight MH - Adolescent MH - Child MH - *Birth Weight/genetics MH - Male MH - Mendelian Randomization Analysis MH - Heart Disease Risk Factors MH - Infant, Newborn MH - Developmental Origins of Health and Disease MH - Epigenesis, Genetic MH - Adult PMC - PMC13474067 OTO - NOTNLM OT - Barker's hypothesis OT - DNA methylation OT - Mendelian randomisation OT - cardiovascular disease risk OT - epigenetics COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/08/14 CRDT- 2026/08/14 05:12 PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 05:12 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - jogh-16-04242 [pii] AID - 10.7189/jogh.16.04242 [doi] PST - epublish SO - J Glob Health. 2026 Aug 14;16:04242. doi: 10.7189/jogh.16.04242. PMID- 42595859 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260912 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Aug 13 TI - Is watchful waiting an alternative to adenotonsillectomy in children with mild to moderate obstructive sleep apnoea? LID - 10.1007/s00431-026-07330-6 [doi] LID - 663 AB - Adenotonsillectomy (ATE) has traditionally been the first-line treatment for obstructive sleep apnoea (OSA) in children. Increasing evidence suggests that many children with mild to moderate OSA may improve without surgery. This mini-review examines whether watchful waiting is a safe and effective alternative to ATE in otherwise healthy children with mild to moderate OSA. We searched PubMed from inception to January 2026 for randomised controlled trials (RCTs) comparing ATE with watchful waiting in children aged 1-16 years with OSA or sleep-disordered breathing confirmed by polysomnography or a validated symptom score. Two reviewers independently screened and extracted data. Results were analysed qualitatively. Five RCTs (seven published reports; n = 1287 children; mean age 6.1 years) met inclusion criteria. Spontaneous OSA resolution occurred in 44-55% of children managed with watchful waiting, compared with 57-79% following ATE. ATE produced statistically greater reductions in the apnoea-hypopnoea index in four of five trials, but between-group differences were modest. The largest and most consistent effects of ATE were seen for OSA symptom scores. CONCLUSION: Watchful waiting is a reasonable option for young, nonobese children with mild OSA, given the relatively high rates of spontaneous resolution. ATE remains appropriate for children with moderate to severe OSA. Shared decision-making, individualised care and close follow-up are essential when watchful waiting is chosen. WHAT IS KNOWN: * Otherwise healthy children with obstructive sleep apnoea due to adenotonsillar hyperplasia are usually managed with adenotonsillectomy. * Young, non-obese, Caucasian children with more mild obstructive sleep apnoea, however, showed a surprisingly high probability of spontaneous resolution of the disease in one study. WHAT IS NEW: * High rates of spontaneous resolution of obstructive sleep apnoea were observed in four independent studies, ranging from 44% to 55%. * Watchful waiting for several months may, thus, be a reasonable management option in a particular low-risk group of children with obstructive sleep apnoea. CI - (c) 2026. The Author(s). FAU - Kuhle, Stefan AU - Kuhle S AD - Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria. FAU - Poets, Christian F AU - Poets CF AD - Department of Neonatology and Division of Paediatric Sleep Medicine, University Children's Hospital, Tubingen, Germany. FAU - Urschitz, Michael S AU - Urschitz MS AD - Division of Paediatric Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany. urschitz@uni-mainz.de. LA - eng PT - Journal Article PT - Review DEP - 20260813 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Watchful Waiting MH - *Sleep Apnea, Obstructive/therapy/surgery MH - *Adenoidectomy MH - *Tonsillectomy MH - Child MH - Child, Preschool MH - Polysomnography MH - Randomized Controlled Trials as Topic MH - Severity of Illness Index MH - Treatment Outcome MH - Adolescent PMC - PMC13473323 OTO - NOTNLM OT - Adenotonsillectomy OT - Apnoea OT - Children OT - Polysomnography OT - Sleep OT - Watchful waiting COIS- Declarations. Ethics approval, accordance, consent to participate and consent to publish: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/14 05:38 MHDA- 2026/08/14 05:39 PMCR- 2026/08/13 CRDT- 2026/08/13 23:55 PHST- 2026/03/23 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/14 05:39 [medline] PHST- 2026/08/14 05:38 [pubmed] PHST- 2026/08/13 23:55 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.1007/s00431-026-07330-6 [pii] AID - 7330 [pii] AID - 10.1007/s00431-026-07330-6 [doi] PST - epublish SO - Eur J Pediatr. 2026 Aug 13;185(9):663. doi: 10.1007/s00431-026-07330-6. PMID- 42595351 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 1447-0756 (Electronic) IS - 1341-8076 (Print) IS - 1341-8076 (Linking) VI - 52 IP - 8 DP - 2026 Aug TI - Evaluation of Maternal Serum ELABELA Levels in Pregnancies Diagnosed With Abortus Imminens Between 8 and 14 Weeks of Gestation. PG - e70450 LID - 10.1111/jog.70450 [doi] LID - e70450 AB - AIM: Abortus imminens is a common condition in early pregnancy characterized by vaginal bleeding with a closed cervix and viable intrauterine pregnancy. Current biochemical markers have limited accuracy in predicting pregnancy outcomes. ELABELA (also known as Apela or Toddler), a peptide involved in angiogenesis and placental development, may serve as a potential biomarker in early pregnancy complications. This study aimed to evaluate maternal serum ELABELA levels in pregnancies diagnosed with abortus imminens. METHODS: This prospective cross-sectional study included 45 pregnant women diagnosed with abortus imminens between 8 and 14 weeks of gestation and 45 healthy controls. Maternal serum ELABELA levels were measured using enzyme-linked immunosorbent assay (ELISA). All serum samples were analyzed simultaneously in a single analytical batch to minimize interassay variability. Statistical analyses included group comparisons, receiver operating characteristic (ROC) curve analysis, and binary logistic regression. RESULTS: There were no significant differences between groups in terms of age, body mass index (BMI), gestational age at sampling, gravidity, or parity (p > 0.05). ELABELA levels were significantly lower in the abortus imminens group compared with controls (median: 649.82 vs. 859.60 pg/mL; p = 0.021). ROC analysis demonstrated modest discriminative ability (area under the curve [AUC] = 0.641; 95% confidence interval [CI]: 0.520-0.751), with an optimal cut-off value of 712.0 pg/mL (sensitivity 60.0%, specificity 68.9%). Logistic regression analysis showed no independent predictive value for ELABELA. CONCLUSION: Maternal serum ELABELA levels are significantly reduced in pregnancies with abortus imminens, suggesting a potential role in early placental dysfunction. Although ELABELA alone may not be a strong independent predictor, it may serve as a complementary biomarker in the evaluation of abortus imminens. Further large-scale prospective studies are needed to confirm these findings. CI - (c) 2026 Japan Society of Obstetrics and Gynecology. FAU - Ozgedik, Simge AU - Ozgedik S AUID- ORCID: 0009-0002-3241-9984 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Herguner, Metehan AU - Herguner M AUID- ORCID: 0000-0003-3182-6430 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Durace, Alihan AU - Durace A AUID- ORCID: 0009-0007-5848-1467 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Al, Cagdas Necati AU - Al CN AUID- ORCID: 0009-0006-0198-8956 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Yucel, Ecem AU - Yucel E AUID- ORCID: 0000-0002-5941-1926 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Ozgokce, Cagdas AU - Ozgokce C AUID- ORCID: 0000-0003-4960-4625 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Kale, Ibrahim AU - Kale I AUID- ORCID: 0000-0001-7802-7199 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. LA - eng PT - Journal Article PL - Australia TA - J Obstet Gynaecol Res JT - The journal of obstetrics and gynaecology research JID - 9612761 RN - 0 (Peptide Hormones) RN - 0 (APELA protein, human) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Peptide Hormones/blood MH - Biomarkers/blood MH - Adult MH - Prospective Studies MH - Cross-Sectional Studies MH - *Pregnancy Trimester, First/blood PMC - PMC13472750 OTO - NOTNLM OT - ELABELA OT - abortus imminens OT - biomarker OT - early pregnancy OT - placental dysfunction COIS- The authors have nothing to report. The authors declare no conflicts of interest. EDAT- 2026/08/14 04:30 MHDA- 2026/08/14 04:31 PMCR- 2026/08/13 CRDT- 2026/08/13 20:33 PHST- 2026/07/08 00:00 [revised] PHST- 2026/05/04 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/14 04:31 [medline] PHST- 2026/08/14 04:30 [pubmed] PHST- 2026/08/13 20:33 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - JOG70450 [pii] AID - 10.1111/jog.70450 [doi] PST - ppublish SO - J Obstet Gynaecol Res. 2026 Aug;52(8):e70450. doi: 10.1111/jog.70450. PMID- 42595669 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261005 IS - 2529-993X (Electronic) IS - 2529-993X (Linking) VI - 44 IP - 8 DP - 2026 Oct TI - Evaluation of risk factors and development of a predictive clinical score for TB contact tracing in Angola. PG - 503251 LID - S2529-993X(26)00152-8 [pii] LID - 10.1016/j.eimce.2026.503251 [doi] AB - INTRODUCTION: Contact tracing for tuberculosis (TB) is an essential component of public health efforts to detect secondary cases and interrupt transmission chains. This study aimed to assess the risk factors associated with TB diagnosis and to develop a predictive clinical score for TB diagnosis among contacts of people with TB attending the outpatient clinic at Hospital Nossa Senhora da Paz (HNSP) in Cubal, Angola. METHODS: Prospective observational study including TB contacts of all ages. Data were analyzed using descriptive and inferential statistics, including multivariable logistic regression with multiple imputation for missing data. The performance of the proposed clinical score was assessed through ROC analysis, calibration, bootstrap internal validation, and comparison with the WHO symptom-based screening approach. RESULTS: Two-hundred and eighty-five TB contacts were included. Fifty (17.5%) contacts were diagnosed with TB, 40 (80%) of whom were children /=6 points, the score showed a sensitivity of 94% and a specificity of 75%, with an area under the ROC curve of 0.89 (95% CI: 0.85-0.94). CONCLUSIONS: These findings highlight the high burden of TB among close contacts and the challenges in properly assessing them. An easy-to-use clinical score may support frontline health workers in improving TB contact tracing in settings with high burden of disease and limited resources, such as Angola. CI - Copyright (c) 2026 Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Martinez-Camprecios, Joan AU - Martinez-Camprecios J AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Aznar, Maria Luisa AU - Aznar ML AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola; Centro de Investigacion Biomedica en Red de Enfermedades (CIBER), Infecciosas, Instituto de Salud Carlos III, Madrid, Spain; Grupo de Estudio de Micobacterias, Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain. Electronic address: maria.aznar@vhir.org. FAU - Espinosa-Pereiro, Juan AU - Espinosa-Pereiro J AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Grupo de Estudio de Micobacterias, Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain; Damien Foundation, Brussels, Belgium. FAU - Aixut, Sandra AU - Aixut S AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Pediatric Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Nindia, Arlete AU - Nindia A AD - Laboratory Department, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Zakarias, Adriano AU - Zakarias A AD - Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Gonzalez-Farias, Inigo AU - Gonzalez-Farias I AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Comella, Patricia AU - Comella P AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain. FAU - Sicaleta, Nicolau AU - Sicaleta N AD - Pediatric Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Sanchez-Montalva, Adrian AU - Sanchez-Montalva A AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades (CIBER), Infecciosas, Instituto de Salud Carlos III, Madrid, Spain; Grupo de Estudio de Micobacterias, Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain. FAU - Molina, Israel AU - Molina I AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades (CIBER), Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article PT - Observational Study DEP - 20260813 PL - Spain TA - Enferm Infecc Microbiol Clin (Engl Ed) JT - Enfermedades infecciosas y microbiologia clinica (English ed.) JID - 101777541 SB - IM MH - Humans MH - Angola/epidemiology MH - Risk Factors MH - *Contact Tracing/methods MH - Prospective Studies MH - *Tuberculosis/diagnosis/epidemiology/transmission MH - Female MH - Male MH - Adolescent MH - Child MH - Adult MH - Child, Preschool MH - Young Adult MH - Middle Aged MH - Infant OTO - NOTNLM OT - Contact-tracing OT - Estudio de contactos OT - Factores de riesgo OT - Risk factors OT - Tuberculosis EDAT- 2026/08/13 23:36 MHDA- 2026/10/01 23:30 CRDT- 2026/08/13 21:58 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/10/01 23:30 [medline] PHST- 2026/08/13 23:36 [pubmed] PHST- 2026/08/13 21:58 [entrez] AID - S2529-993X(26)00152-8 [pii] AID - 10.1016/j.eimce.2026.503251 [doi] PST - ppublish SO - Enferm Infecc Microbiol Clin (Engl Ed). 2026 Oct;44(8):503251. doi: 10.1016/j.eimce.2026.503251. Epub 2026 Aug 13. PMID- 42595242 OWN - NLM STAT- Publisher LR - 20260917 IS - 1532-821X (Electronic) IS - 0003-9993 (Linking) DP - 2026 Aug 13 TI - Explorer: Safety and Usability of a Gait Exoskeleton for Children With Motor Disabilities in Natural Environments. LID - S0003-9993(26)00879-8 [pii] LID - 10.1016/j.apmr.2026.08.005 [doi] AB - OBJECTIVE: To evaluate the safety and usability of an exoskeleton designed for personal use in real-world settings in children with motor disabilities. DESIGN: Prospective, multicenter, open-label safety and usability study. SETTING: Participants' homes and their usual community environments. PARTICIPANTS: Fifty children aged 2-17 years (25 boys, 25 girls) diagnosed with neurological or neuromuscular disease. INTERVENTION: Participants completed 8 sessions using the Explorer personal exoskeleton in home and community settings guided by their caregivers and the researchers. MAIN OUTCOME MEASURES: Safety was assessed by monitoring adverse events, while usability outcomes included donning time, level of assistance required, user satisfaction (Quebec User Evaluation of Satisfaction with Assistive Technology 2.0 questionnaire), and device usage data (usage time, number of steps, number of environments where the device was used). RESULTS: The device was used in 94% of planned sessions, and no serious adverse events were recorded. Donning times averaged 4.7+/-1.8 minutes, and satisfaction scores were high with median Quebec User Evaluation of Satisfaction with Assistive Technology 2.0 scores of 4 out of 5. The device was used equally in indoor (52.7%) and outdoor (47.3%) environments, including schools and playgrounds, and the average time of use per session was 21.2+/-15.1 minutes, whereas the average number of steps taken per session was 392.0+/-244.0 steps. CONCLUSION: The study provides preliminary evidence that the pediatric exoskeleton is safe and usable in real‑world settings. Its use in the daily lives of children with motor disabilities may contribute to improved mobility and support participation in everyday activities, aligning with World Health Organization recommendations for physical activity and the F-Words framework for child development. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Gor-Garcia-Fogeda, Maria Dolores AU - Gor-Garcia-Fogeda MD AD - Department of Physiotherapy, Physical Medicine and Rehabilitation, King Juan Carlos University, Madrid, Spain. FAU - Martinez-Caballero, Ignacio AU - Martinez-Caballero I AD - Department of Pediatric Orthopedic Surgery and Traumatology, University Children's Hospital Nino Jesus, Madrid, Spain. FAU - Arroyo-Riano, Olga AU - Arroyo-Riano O AD - Department of Physical Medicine and Rehabilitation, General University Hospital Gregorio Maranon, Madrid, Spain. FAU - Vara-Arias, Maria Teresa AU - Vara-Arias MT AD - Department of Physical Medicine and Rehabilitation, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Espinosa-Garcia, Sandra AU - Espinosa-Garcia S AD - Department of Physical Medicine and Rehabilitation, La Paz University Hospital, Madrid, Spain. FAU - Garcia-de-Las-Penas, Sofia AU - Garcia-de-Las-Penas S AD - Department of Physical Medicine and Rehabilitation, 12 de Octubre University Hospital, Madrid, Spain. FAU - Cumplido-Trasmonte, Carlos AU - Cumplido-Trasmonte C AD - Marsi Bionics SL, Madrid, Spain. FAU - Fernandez, Roemi AU - Fernandez R AD - Centre for Automation and Robotics, Spanish National Research Council, Madrid, Spain. Electronic address: roemi.fernandez@car.upm-csic.es. FAU - Garcia-Armada, Elena AU - Garcia-Armada E AD - Marsi Bionics SL, Madrid, Spain. CN - Explorer Study Group LA - eng PT - Journal Article DEP - 20260813 PL - United States TA - Arch Phys Med Rehabil JT - Archives of physical medicine and rehabilitation JID - 2985158R SB - IM OTO - NOTNLM OT - Cerebral palsy OT - Exoskeleton OT - F-Words OT - Mobility OT - Pediatric OT - Physical activity OT - Rehabilitation EDAT- 2026/08/13 23:36 MHDA- 2026/08/13 23:36 CRDT- 2026/08/13 19:22 PHST- 2026/03/23 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/13 23:36 [pubmed] PHST- 2026/08/13 23:36 [medline] PHST- 2026/08/13 19:22 [entrez] AID - S0003-9993(26)00879-8 [pii] AID - 10.1016/j.apmr.2026.08.005 [doi] PST - aheadofprint SO - Arch Phys Med Rehabil. 2026 Aug 13:S0003-9993(26)00879-8. doi: 10.1016/j.apmr.2026.08.005. PMID- 42594584 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260923 IS - 1873-5711 (Electronic) IS - 1050-6411 (Linking) VI - 90 DP - 2026 Oct TI - Nonimpaired literature-derived scaling does not accurately represent the shoulder and elbow strength of children and adults with paraplegia. PG - 103197 LID - S1050-6411(26)00094-5 [pii] LID - 10.1016/j.jelekin.2026.103197 [doi] AB - This study evaluated whether participant characteristics, literature-derived regression equations, and a generic musculoskeletal model developed for nonimpaired populations could accurately predict maximal shoulder and elbow strength in children and adults with paraplegia. Thirty individuals with paraplegia (22 adults, 8 children) completed maximal voluntary isometric contractions (MVICs) in seven upper extremity postures. Predicted MVICs were generated using a scaled OpenSim upper extremity model with three muscle activation inputs (Full, Separated, and EMG-informed). Linear mixed-effects models evaluated relationships between predicted and experimentally measured MVICs across postures. Model performance was assessed using marginal and conditional R(2), root mean square error (RMSE), mean absolute error (MAE), Lin's concordance correlation coefficient (CCC), and repeated-measures Bland-Altman analyses. Agreement between measured and height-predicted upper extremity segment lengths was also evaluated. Joint posture significantly influenced measured MVIC, and significant posture-by-predicted MVIC interactions demonstrated that prediction accuracy was posture dependent (all p < 0.001). The Full activation input explained the greatest proportion of variance in measured MVIC (marginal R(2) = 0.770; conditional R(2) = 0.931), whereas the EMG-informed activation input produced the lowest prediction error (RMSE = 22.38% MVIC; MAE = 17.14% MVIC). However, agreement between predicted and measured MVIC remained modest across all activation inputs (CCC = 0.259-0.312), with systematic bias evident in Bland-Altman analyses. Height-based anthropometric scaling overestimated forearm and humerus lengths by 1.25 and 4.96 cm, respectively, with greater error for the humerus (RMSE = 5.82 cm). Regression-based scaling and generic musculoskeletal models derived from nonimpaired populations provided only modest estimates of maximal upper extremity strength in individuals with paraplegia. Improving strength prediction will require innovative scaling approaches that incorporate participant-specific anthropometry, population-specific muscle properties, and individualized neuromuscular activation while balancing model accuracy with practical clinical feasibility. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Zhao, Hanhsen AU - Zhao H AD - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA. FAU - Cho, Yeajin AU - Cho Y AD - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA. FAU - Schnorenberg, Alyssa J AU - Schnorenberg AJ AD - Department of Biomedical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI, USA; Department of Occupational Science and Technology, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. FAU - Slavens, Brooke A AU - Slavens BA AD - Department of Biomedical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI, USA; Department of Occupational Science and Technology, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. FAU - Peterson, Carrie L AU - Peterson CL AD - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: clpeterson@vcu.edu. LA - eng PT - Journal Article DEP - 20260810 PL - England TA - J Electromyogr Kinesiol JT - Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology JID - 9109125 SB - IM MH - Humans MH - *Paraplegia/physiopathology MH - Child MH - Male MH - Female MH - Adult MH - *Muscle Strength/physiology MH - Isometric Contraction/physiology MH - *Muscle, Skeletal/physiopathology MH - *Elbow Joint/physiopathology MH - *Models, Biological MH - *Shoulder Joint/physiopathology MH - Reproducibility of Results MH - Sensitivity and Specificity OTO - NOTNLM OT - Musculoskeletal modeling OT - Peak isometric moment OT - Spinal cord injury OT - Upper extremity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/13 23:36 MHDA- 2026/09/23 23:55 CRDT- 2026/08/13 18:05 PHST- 2025/06/30 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/09/23 23:55 [medline] PHST- 2026/08/13 23:36 [pubmed] PHST- 2026/08/13 18:05 [entrez] AID - S1050-6411(26)00094-5 [pii] AID - 10.1016/j.jelekin.2026.103197 [doi] PST - ppublish SO - J Electromyogr Kinesiol. 2026 Oct;90:103197. doi: 10.1016/j.jelekin.2026.103197. Epub 2026 Aug 10. PMID- 42594228 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20260928 IS - 1536-3678 (Electronic) IS - 1077-4114 (Linking) VI - 48 IP - 7 DP - 2026 Oct 1 TI - Beyond Tumor Size: Hilar-to-Central Vessel Distance as a Complementary Safety Metric for Laparoscopic Nephrectomy in Wilms Tumor. PG - 323-330 LID - 10.1097/MPH.0000000000003264 [doi] AB - BACKGROUND: Laparoscopic nephrectomy for Wilms tumor remains controversial despite growing evidence supporting its feasibility. This study analyzed surgical and oncological outcomes according to the SIOP criteria and evaluated the hilar-to-central vessel distance as a potential selection parameter. METHODS: Retrospective analysis of 50 children with unilateral Wilms tumor treated between 2014 and 2020. Patients underwent open (ON=38) or laparoscopic (LN=12) nephrectomy following SIOP protocols. Laparoscopic selection required: tumor confined to the kidney, not crossing vertebral border, no venous thrombus, volume 1 year. The definition of advanced BA as BA-CA >1 year is widely adopted in clinical pediatric practice in China. RESULTS: The prevalence of advanced BA was 7.9%, with significantly higher rates in girls (11.9% vs. 3.4% in boys, P<0.001), children aged 9-12 years (19.4%), and those with overweight (17.1%) or obesity (16.9%) compared to normal weight children (5.8%, P<0.001). Body mass index (BMI) was positively correlated with advanced BA (Spearman rho=0.361, P<0.001) and exhibited moderate predictive value for advanced BA [area under the curve (AUC) =0.735; 95% confidence interval (CI): 0.684-0.786]. Overweight and obesity were associated with increased odds of advanced BA after adjustment for age and sex [overweight: odds ratio (OR) =2.49, 95% CI: 1.435-4.314, P<0.05; obesity: OR =2.33, 95% CI: 1.463-3.71, P<0.001], whereas serum 25(OH)D levels showed no significant association. CONCLUSIONS: Overweight and obesity were significantly associated with advanced BA in this cross-sectional cohort of children from northwest China, whereas no significant association was detected between serum 25(OH)D and advanced BA. These findings highlight the importance of nutritional monitoring for healthy skeletal development in economically transitioning regions. CI - (c) AME Publishing Company. FAU - Li, Tingting AU - Li T AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Nan, Nan AU - Nan N AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Wei, Wenjie AU - Wei W AD - Academy of Fine Art & Design, Northwest Normal University, Lanzhou, China. FAU - Zhu, Yin AU - Zhu Y AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Huang, Lei AU - Huang L AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Ma, Xuerong AU - Ma X AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Du, Yongxia AU - Du Y AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Zhang, Naqi AU - Zhang N AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - An, Dandan AU - An D AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Bai, Wenjie AU - Bai W AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Fan, Hongyan AU - Fan H AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Wang, Chen AU - Wang C AD - Department of Scientific and Technological Development, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Da, Zhenqiang AU - Da Z AD - Department of Medical Administration, Gansu Provincial Cancer Hospital, Lanzhou, China. FAU - Xie, Xingwen AU - Xie X AUID- ORCID: 0009-0006-2454-635X AD - Department of Orthopedics, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China. LA - eng PT - Journal Article DEP - 20260629 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13462753 OTO - NOTNLM OT - Body mass index (BMI) OT - bone age (BA) OT - children OT - northwest China OT - serum 25-hydroxyvitamin D [serum 25(OH)D] COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0378/coif). The authors have no conflicts of interest to declare. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/31 CRDT- 2026/08/13 06:56 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 06:56 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - tp-15-07-266 [pii] AID - 10.21037/tp-2026-0378 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jul 31;15(7):266. doi: 10.21037/tp-2026-0378. Epub 2026 Jun 29. PMID- 42592010 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 7 DP - 2026 Jul 31 TI - Development of a parsimonious predictive model for height gain outcome in children with central precocious puberty following gonadotropin-releasing hormone agonist therapy. PG - 284 LID - 10.21037/tp-2026-0254 [doi] LID - 284 AB - BACKGROUND: Central precocious puberty (CPP) is associated with compromised adult height if untreated, and gonadotropin-releasing hormone agonist (GnRHa) therapy remains the standard treatment. However, height gain during treatment varies considerably among patients, and clinically practical tools for early identification of children at risk for suboptimal growth response are lacking. This study aimed to identify prognostic determinants of suboptimal height gain during GnRHa therapy and to develop a parsimonious predictive model to facilitate evidence-based clinical decision-making and optimal intervention timing. METHODS: A retrospective cohort study was conducted enrolling children with CPP treated with triptorelin. Baseline clinical and biochemical parameters were collected, including chronological age, height standard deviation score (SDS), body mass index (BMI) SDS, insulin-like growth factor-1 (IGF-1) SDS, bone age advancement [bone age minus chronological age (BA-CA)], Tanner stage, GnRH-stimulated luteinizing hormone (LH) peak, and serum estradiol concentrations. Patients were stratified into favorable and unfavorable outcome cohorts based on height gain during treatment. Univariate and multivariable logistic regression analyses were performed to identify independent predictors. Three predictive models were constructed: M0 (comprehensive model with five predictors: IGF-1 SDS, BMI SDS, BA-CA, Tanner stage, and age), M1 (univariate model with IGF-1 SDS), and M2 (parsimonious model with IGF-1 SDS and BA-CA). Model performance was assessed using receiver operating characteristic (ROC) curves, calibration plots, decision curve analysis (DCA; 1-50% risk thresholds), and bootstrap internal validation. RESULTS: A total of 163 children with CPP were enrolled (favorable outcome: n=113; unfavorable outcome: n=50). Multivariable logistic regression identified BMI SDS [odds ratio (OR) =2.33, 95% confidence interval (CI): 1.14-4.76, P=0.02], IGF-1 SDS (OR =1.94, 95% CI: 1.24-3.02, P=0.004), and bone age advancement (OR =21.49, 95% CI: 5.41-85.30, P<0.001) as independent predictors for unfavorable outcome. The area under the curve (AUC) was 0.838 (95% CI: 0.774-0.903) for M0, 0.664 (95% CI: 0.573-0.754) for M1, and 0.815 (95% CI: 0.748-0.883) for M2. DeLong test revealed no significant difference between M2 and M0 (DeltaAUC =-0.023, P=0.24). Bootstrap internal validation (1,000 iterations) demonstrated optimism-corrected AUC values of 0.810, 0.661, and 0.807 for M0, M1, and M2, respectively. M2 exhibited optimal calibration slope (0.957, 95% CI: 0.642-1.389) closest to unity. Brier scores were 0.160 for M0 and 0.167 for M2. DCA demonstrated comparable clinical net benefit for M0 and M2 across 1-50% risk thresholds. CONCLUSIONS: The parsimonious model (M2) incorporating IGF-1 SDS and bone age advancement demonstrates robust predictive capability for height gain outcome in children with CPP receiving GnRHa therapy, comparable to the comprehensive model. This model may support early risk stratification and closer growth monitoring in selected patients; however, external validation and confirmation against final adult height outcomes are required before it can inform decisions about adjunctive interventions. CI - (c) AME Publishing Company. FAU - Lin, Xiaohong AU - Lin X AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Lin, Kai AU - Lin K AD - Department of Radiology, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Ye, Pengcheng AU - Ye P AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Wang, Ben AU - Wang B AD - Department of Laboratory, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Huang, Chongbin AU - Huang C AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Hong, Jianyu AU - Hong J AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Xue, Yunyun AU - Xue Y AD - Department of Medical Affairs, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Qian, Xiaoquan AU - Qian X AUID- ORCID: 0009-0002-9549-5677 AD - Department of Pathology, Yueqing Maternal and Child Health Hospital, Yueqing, China. LA - eng PT - Journal Article DEP - 20260727 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13462843 OTO - NOTNLM OT - Central precocious puberty (CPP) OT - bone age OT - gonadotropin-releasing hormone agonist (GnRHa) OT - height outcome OT - insulin-like growth factor-1 (IGF-1) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0254/coif). The authors have no conflicts of interest to declare. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/31 CRDT- 2026/08/13 06:52 PHST- 2026/03/12 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 06:52 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - tp-15-07-284 [pii] AID - 10.21037/tp-2026-0254 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jul 31;15(7):284. doi: 10.21037/tp-2026-0254. Epub 2026 Jul 27. PMID- 42591968 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 7 DP - 2026 Jul 31 TI - An interpretable machine learning model based on routine clinical indicators for early identification of obesity-related non-alcoholic fatty liver disease in children: a single-center retrospective study. PG - 275 LID - 10.21037/tp-2026-0371 [doi] LID - 275 AB - BACKGROUND: There is still a lack of a noninvasive, individualized tool to pre-screen children with obesity for the risk of non-alcoholic fatty liver disease (NAFLD) and to prioritize referral for confirmatory abdominal ultrasonography. In this study, we aimed to develop and interpret a machine learning (ML)-based model for predicting ultrasound-defined NAFLD risk among children with obesity using routine clinical and biochemical indicators. METHODS: This single-center retrospective study included 439 obese children treated at Siyang Hospital between February 2021 and December 2025. Demographic, anthropometric, and routine laboratory indicators were collected, and ultrasound-defined NAFLD was used as the study outcome. Least absolute shrinkage and selection operator (LASSO) regression and the Boruta algorithm were applied to identify robust predictive features, and six ML models-logistic regression, decision tree, random forest, extreme gradient boosting (XGBoost), light gradient boosting machine (LightGBM), and support vector machine (SVM)-were developed and compared to determine the optimal model. Model performance was evaluated in the test set, and Shapley Additive exPlanations (SHAP) was used to interpret the final model. RESULTS: A total of 439 obese children were included in the analysis, of whom 206 (46.9%) had ultrasound-defined NAFLD. Seven variables were selected to develop six ML models. Among these, the LightGBM model showed the best overall performance across multiple metrics, with comparable discrimination among the top models in the test set, with an area under the curve (AUC) of 0.870, accuracy of 0.823, precision of 0.828, sensitivity of 0.787, specificity of 0.855, and F1 score of 0.807. SHAP analysis further demonstrated that waist-to-height ratio contributed most to the model output, followed by body mass index (BMI), triglyceride-glucose index x waist circumference (TyG-WC), serum uric acid, and triglyceride-glucose index x body mass index (TyG-BMI). CONCLUSIONS: This study developed an interpretable ML-based model for predicting ultrasound-defined NAFLD risk in obese children using routine clinical and biochemical indicators. LightGBM showed the best overall predictive performance, with good calibration and potential clinical utility. It may serve as a noninvasive auxiliary tool to pre-screen children with obesity and prioritize referral for confirmatory abdominal ultrasonography, supporting early identification and risk assessment of ultrasound-defined NAFLD, although further multicenter prospective studies and external validation are still needed before broader clinical application. CI - (c) AME Publishing Company. FAU - Zhuang, Lili AU - Zhuang L AD - Department of Pediatrics, Siyang Hospital, Suqian, China. FAU - Dai, Jinxing AU - Dai J AD - Department of Pediatrics, Siyang Hospital, Suqian, China. FAU - Wang, Jiajia AU - Wang J AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Shi, Qianjin AU - Shi Q AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Shen, Kang AU - Shen K AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Qiu, Hao AU - Qiu H AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Qiu, Weibing AU - Qiu W AD - Department of Pediatrics, Siyang Hospital, Suqian, China. LA - eng PT - Journal Article DEP - 20260627 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13462896 OTO - NOTNLM OT - Childhood obesity OT - Shapley Additive exPlanations (SHAP) OT - light gradient boosting machine (LightGBM) OT - machine learning (ML) OT - non-alcoholic fatty liver disease (NAFLD) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0371/coif). The authors have no conflicts of interest to declare. EDAT- 2026/08/13 12:43 MHDA- 2026/08/13 12:44 PMCR- 2026/07/31 CRDT- 2026/08/13 06:48 PHST- 2026/04/17 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/08/13 12:44 [medline] PHST- 2026/08/13 12:43 [pubmed] PHST- 2026/08/13 06:48 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - tp-15-07-275 [pii] AID - 10.21037/tp-2026-0371 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jul 31;15(7):275. doi: 10.21037/tp-2026-0371. Epub 2026 Jun 27. PMID- 42591473 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Diagnosis and treatment of vitamin B12 deficiency in children. PG - 1883501 LID - 10.3389/fnut.2026.1883501 [doi] LID - 1883501 AB - Vitamin B12 deficiency is a common yet frequently underrecognized nutritional disorder with important public health implications, particularly in low- and middle-income countries where maternal deficiency, vegetarian dietary practices, and food insecurity are prevalent. In children, deficiency may lead to irreversible neurodevelopmental impairment, growth failure, and hematological abnormalities, making early recognition essential. The clinical spectrum ranges from asymptomatic biochemical deficiency and isolated macrocytic anemia to developmental regression, seizures, movement disorders, peripheral neuropathy, and pancytopenia, with neurological manifestations often preceding hematological changes. Diagnosis requires integration of clinical features with laboratory evaluation, including complete blood count, peripheral smear, serum vitamin B12 estimation, and functional biomarkers such as methylmalonic acid and homocysteine, which improve diagnostic accuracy in borderline or atypical cases. Molecular testing has expanded the identification of inherited disorders affecting vitamin B12 absorption and metabolism, enabling timely lifelong management. Prompt replacement therapy is the cornerstone of treatment and should not be delayed when clinical suspicion is high. Oral supplementation is effective for most dietary deficiencies, whereas parenteral therapy is indicated for severe anemia, neurological involvement, malabsorption, or inherited cobalamin disorders. Early treatment results in rapid hematological recovery, but delayed intervention may leave permanent neurological sequelae despite biochemical correction. Beyond individual patient care, strengthening maternal nutrition, targeted screening of high-risk populations, food fortification, and public awareness are critical strategies to reduce the burden of vitamin B12 deficiency and prevent avoidable disability. This review summarizes current evidence on the diagnosis and treatment of pediatric vitamin B12 deficiency and highlights practical approaches for improving clinical outcomes. CI - Copyright (c) 2026 Kanvinde, Khurana and Mudaliar. FAU - Kanvinde, Purva AU - Kanvinde P AD - Department of Paediatric Hematology-Oncology, Bai Jerbai Wadia Hospital for Children, Mumbai, India. FAU - Khurana, Ritika AU - Khurana R AD - Department of Paediatric Hematology-Oncology, Bai Jerbai Wadia Hospital for Children, Mumbai, India. FAU - Mudaliar, Sangeeta AU - Mudaliar S AD - Department of Paediatric Hematology-Oncology, Bai Jerbai Wadia Hospital for Children, Mumbai, India. LA - eng PT - Journal Article PT - Review DEP - 20260729 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13462225 OTO - NOTNLM OT - holotranscobalamin OT - inherited vitamin B12 disorders OT - methylmalonic acid levels OT - treatment of vitamin B12 deficiency OT - vitamin B12 deficiency COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/29 CRDT- 2026/08/13 05:52 PHST- 2026/05/17 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 05:52 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.3389/fnut.2026.1883501 [doi] PST - epublish SO - Front Nutr. 2026 Jul 29;13:1883501. doi: 10.3389/fnut.2026.1883501. eCollection 2026. PMID- 42591247 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - The impact of physical activity on executive function in college students: the chain mediating role of anxiety and sleep quality. PG - 1853278 LID - 10.3389/fpsyg.2026.1853278 [doi] LID - 1853278 AB - BACKGROUND AND OBJECTIVES: Executive function (EF) serves as a critical regulatory hub for goal-directed behavior, yet its operational integrity is increasingly threatened by the sedentary lifestyles and psychological stressors prevalent in higher education. While the cognitive benefits of exercise are documented, the specific pathways through which it navigates psychological and physiological barriers remain underexplored. This study constructs a chain mediation model to elucidate how physical activity (PA) optimizes EF by sequentially modulating anxiety and sleep quality (SQ) among university students. METHODS: Data collection was conducted in December 2025, involving a multi-stage cluster convenience sample of 2,033 students across six Chinese provinces. Participants (mean age 19.0 +/- 1.1) completed a battery of validated instruments, including the Single-Item Measure for PA, the GAD-2 for anxiety, the Single-Item Sleep Quality Scale, and the Adolescent Executive Function Scale. Structural relationships were analyzed using the SPSS PROCESS macro (Model 6) while controlling for demographic covariates such as gender, age, and socioeconomic background. RESULTS: Path analysis confirmed that PA positively predicts EF proficiency, with the direct effect accounting for 49.53% of the total variance. Beyond this direct link, the relationship is substantiated by three distinct mediating trajectories: (1) a psychological pathway via anxiety reduction (31.78%), (2) a physiological pathway via enhanced sleep quality (14.02%), (3) a sequential chain pathway wherein PA alleviates anxiety, which subsequently optimizes sleep, leading to superior executive performance (4.67%). All mediating effects reached statistical significance as evidenced by bootstrap confidence intervals. CONCLUSION: These findings transition the understanding of physical intervention from a unilinear correlation to a multi-systemic synergistic response. Exercise functions not only as a cognitive catalyst but also as a vital buffer that prevents the maladaptive depletion of neural resources by stabilizing emotional oscillations and facilitating physiological restoration. The results underscore the necessity for higher education institutions to integrate physical activity, psychological counseling, and sleep hygiene management into a cohesive framework for cognitive health. CI - Copyright (c) 2026 Li, Wan, Ru, Wang, Wang, Liu, Liang, Zhang and Bao. FAU - Li, Yuhao AU - Li Y AD - Beijing Sport University, Beijing, China. FAU - Wan, Xiaotong AU - Wan X AD - School of Nursing, Anhui Medical University, Hefei, China. FAU - Ru, Aojie AU - Ru A AD - School of Nursing, Anhui Medical University, Hefei, China. FAU - Wang, Yanfei AU - Wang Y AD - Department of Science and Education, Xilingol League Central Hospital, Xilinhot, China. FAU - Wang, Jing AU - Wang J AD - Department of Anesthesiology for Surgery, Xilingol League Central Hospital, Xilinhot, China. FAU - Liu, Yang AU - Liu Y AD - Jishou University, Jishou, China. FAU - Liang, Zhiru AU - Liang Z AD - Department of Hepatobiliary Surgery, Xilingol League Central Hospital, Xilinhot, China. FAU - Zhang, Hui AU - Zhang H AD - School of Nursing, Anhui Medical University, Hefei, China. AD - Department of Nursing, The First Affiliated Hospital of Anhui Medical University (Anhui Public Health Clinical Center), Hefei, China. FAU - Bao, Yin AU - Bao Y AD - Department of Hepatobiliary Surgery, Xilingol League Central Hospital, Xilinhot, China. LA - eng PT - Journal Article DEP - 20260729 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13461551 OTO - NOTNLM OT - anxiety OT - chain mediation OT - college students OT - executive function OT - physical activity OT - sleep quality COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/29 CRDT- 2026/08/13 05:22 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 05:22 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1853278 [doi] PST - epublish SO - Front Psychol. 2026 Jul 29;17:1853278. doi: 10.3389/fpsyg.2026.1853278. eCollection 2026. PMID- 42591177 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 16 DP - 2026 TI - Early clinical determinants of adverse outcomes in paediatric febrile neutropenia: a prospective cohort study. PG - 1876009 LID - 10.3389/fonc.2026.1876009 [doi] LID - 1876009 AB - BACKGROUND: Febrile neutropenia (FN) remains a major cause of morbidity and mortality in paediatric haemato-oncology, but routinely available determinants of adverse in-hospital outcome remain incompletely characterised. We aimed to identify baseline clinical, haematological, biochemical, and microbiological factors associated with in-hospital mortality and prolonged fever. METHODS: We conducted a prospective single-centre cohort study of 90 consecutive FN admissions in paediatric haemato-oncology patients. Thirty-nine prespecified baseline predictors were evaluated using Firth penalised-likelihood logistic regression. Multivariable models were prespecified on clinical grounds, and discrimination was internally validated using 500 bootstrap replicates with optimism correction. Prolonged fever was defined as time to defervescence >5 days, with death before defervescence counted as an event. RESULTS: Of 86 mortality-evaluable episodes, 16 children died in hospital (18.6%). In the multivariable mortality model, any respiratory support (adjusted odds ratio [aOR], 11.9; 95% CI, 2.5-56.9) and lower admission albumin (aOR, 0.29 per 1 g/dL increase; 95% CI, 0.11-0.77) showed the strongest associations with death. Active disease (aOR 3.5, 95% CI 0.87-14.2) and gram-negative bacteraemia (aOR 4.2, 95% CI 0.93-18.9) showed directionally adverse but imprecise associations. The bootstrap-corrected AUC was 0.88. Of 60 classifiable episodes for the secondary outcome, 31 (51.7%) had prolonged fever. Prolonged fever was associated with older age (aOR 1.24 per year, 95% CI 1.05-1.48), lower albumin (aOR 0.31 per 1 g/dL increase, 95% CI 0.12-0.82), any respiratory support (aOR 10.0, 95% CI 0.98-102.0), and gram-negative bacteraemia (aOR 5.5, 95% CI 1.01-30.3). The bootstrap-corrected AUC was 0.85. Neutropenia depth and platelet count were not independently associated with either outcome. CONCLUSION: In paediatric haemato-oncology patients with FN, adverse in-hospital outcomes were associated mainly with early or evolving respiratory compromise, lower admission albumin, active disease, and gram-negative bacteraemia. Three of these factors, together with age, were associated with prolonged fever or death before defervescence among classifiable episodes. Albumin should be interpreted as a dynamic marker of acute inflammatory burden, capillary leak, and host reserve rather than as a standalone nutritional measure. These routinely available variables may support exploratory bedside risk appraisal, but external validation is required before clinical implementation. CI - Copyright (c) 2026 Maji, Radhakrishnan, Verma, Diptivilasa and Mandal. FAU - Maji, Manideepa AU - Maji M AD - Postgraduate Institute of Child Health, Noida, India. AD - Hull York Medical School, University of Hull, Hull, United Kingdom. AD - Department of Haematology, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom. FAU - Radhakrishnan, Nita AU - Radhakrishnan N AD - Postgraduate Institute of Child Health, Noida, India. FAU - Verma, Shruti AU - Verma S AD - Postgraduate Institute of Child Health, Noida, India. FAU - Diptivilasa, Aishvarya AU - Diptivilasa A AD - Postgraduate Institute of Child Health, Noida, India. FAU - Mandal, Saikat AU - Mandal S AD - Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom. AD - NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. LA - eng PT - Journal Article DEP - 20260729 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC13461490 OTO - NOTNLM OT - blood cancer OT - childhood cancer OT - febrile neutropenia (FN) OT - neutropenic fever OT - paediatric cancer OT - paediatric cancer care COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/13 12:43 MHDA- 2026/08/13 12:44 PMCR- 2026/07/29 CRDT- 2026/08/13 05:12 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/13 12:44 [medline] PHST- 2026/08/13 12:43 [pubmed] PHST- 2026/08/13 05:12 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.3389/fonc.2026.1876009 [doi] PST - epublish SO - Front Oncol. 2026 Jul 29;16:1876009. doi: 10.3389/fonc.2026.1876009. eCollection 2026. PMID- 42591094 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutrition knowledge among adolescents who participate in sports: a cross-sectional study from Vancouver, Canada. PG - 1898385 LID - 10.3389/fnut.2026.1898385 [doi] LID - 1898385 AB - BACKGROUND: Adequate nutrition, defined as meeting energy and nutrient requirements to support sport-related needs, metabolic function, and growth, is critical for adolescent (14-18 years) athletic performance and health. Many adolescents do not meet current nutrition recommendations and report poor awareness of their nutrient needs (i.e., nutrition knowledge), though trends may differ between male and female adolescents. Most evidence is derived from the United States, with limited data from Canadian populations. The aim of this study was to assess sport nutrition knowledge among male and female adolescents participating in organized sport in the Greater Vancouver area (Canada). METHODS: Adolescents participating in organized sport completed an online questionnaire that collected information on their sport participation, nutrition support and nutrition knowledge using the validated Abridged Nutrition for Sport Knowledge Questionnaire (A-NSKQ; 35 items). Descriptive statistics were generated, and independent samples t-tests assessed sex differences. Multivariable linear regression models were used to compare nutrition knowledge scores between sexes while adjusting for age and sports participation characteristics. RESULTS: Fifty-one adolescents participated (n = 31 females). Few adolescents reported access to a team dietitian (6.1%) or structured nutrition education (26.5%). The mean total A-NSKQ score was 16.49 +/- 4.38 (47.1% correct), indicating poor nutrition knowledge. Mean general and sport nutrition scores were 6.14 +/- 1.92 (of 11) and 10.35 +/- 3.08 (of 24), respectively. No significant sex differences were observed in total, general, or sport nutrition knowledge (all p > 0.05). CONCLUSION: Adolescent athletes in this Greater Vancouver sample demonstrated poor nutrition knowledge, with no differences between sexes. Limited access to dietitians and structured education suggests a need for improved sport nutrition education to support health and athletic development. CI - Copyright (c) 2026 Zhang, Deslippe, McKendry and Cohen. FAU - Zhang, Enhui Evelyn AU - Zhang EE AD - Food, Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada. FAU - Deslippe, Alysha L AU - Deslippe AL AD - Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, QC, Canada. FAU - McKendry, James AU - McKendry J AD - Food, Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada. FAU - Cohen, Tamara R AU - Cohen TR AD - Food, Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Healthy Starts, BC Children's Hospital, Vancouver, BC, Canada. LA - eng PT - Journal Article DEP - 20260729 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13461317 OTO - NOTNLM OT - Canada OT - adolescent athletes OT - dietary behaviour OT - nutrition education OT - sports nutrition knowledge COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/13 12:43 MHDA- 2026/08/13 12:44 PMCR- 2026/07/29 CRDT- 2026/08/13 05:01 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/13 12:44 [medline] PHST- 2026/08/13 12:43 [pubmed] PHST- 2026/08/13 05:01 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.3389/fnut.2026.1898385 [doi] PST - epublish SO - Front Nutr. 2026 Jul 29;13:1898385. doi: 10.3389/fnut.2026.1898385. eCollection 2026. PMID- 42590622 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 15 DP - 2026 Aug 1 TI - Assessing Sprint Mechanical Outputs Derived from LPS, Radar and Laser Technologies in Basketball. LID - 10.3390/s26154845 [doi] LID - 4845 AB - Sprint mechanical profiling is widely used in team sports, yet the agreement between field-based measurement systems in indoor environments remains unclear. This study compared sprint mechanical outputs derived from a Kinexon local positioning system (LPS), radar, and laser during maximal indoor basketball sprints and examined their inter-system agreement and inter-trial reliability. Twenty-two elite youth basketball players performed maximal 28 m linear sprints recorded simultaneously using the three technologies. Sprint kinematics were modeled using a mono-exponential approach applied to the native signals provided by each system to derive theoretical maximal velocity (S(0)), theoretical maximal acceleration (A(0)), and acceleration time constant (Tau). Inter-system agreement was assessed using mean bias and 95% limits of agreement, while inter-trial reliability was evaluated using coefficients of variation (CV), change in the mean, and standard error of measurement. Radar and laser showed close agreement for S(0) (bias = -0.07 +/- 0.17 m.s(-1); relative error = 0.89%), whereas LPS systematically overestimated S(0), with relative systematic errors of 5.26-6.49%. Acceleration-related parameters exhibited larger inter-system discrepancies, with relative errors up to 3.92% for A(0) and 10.55% for Tau. Inter-trial reliability was high across all systems (CV < 1.5% for S(0) and 3.7-4.7% for A(0) and Tau). These findings indicate that sprint mechanical outputs should not be used interchangeably across technologies, particularly for acceleration-related variables, although all systems remain suitable for within-system longitudinal monitoring in applied basketball settings. FAU - Irid, Yannis AU - Irid Y AUID- ORCID: 0009-0006-9648-4127 AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. AD - Institut National du Sport, de l'Expertise et de la Performance (INSEP), 75012 Paris, France. AD - Federation Francaise de Basketball (FFBB), 75013 Paris, France. FAU - Fenaux, Eric AU - Fenaux E AD - Ef-E-Sciences, Independent Scientific Consultancy, 75009 Paris, France. FAU - Legoupil, Romeo AU - Legoupil R AUID- ORCID: 0009-0001-7362-5402 AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. FAU - Tachdjian, Mathis AU - Tachdjian M AD - Institut National du Sport, de l'Expertise et de la Performance (INSEP), 75012 Paris, France. FAU - Leduc, Cedric AU - Leduc C AUID- ORCID: 0000-0002-8054-546X AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. AD - Center for Human Performance, Carnegie School of Sport, Leeds Beckett University, Leeds LS1 3HE, UK. AD - Federation Francaise de Tennis (FFT), 75016 Paris, France. FAU - Toussaint, Jean-Francois AU - Toussaint JF AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. AD - Institut National du Sport, de l'Expertise et de la Performance (INSEP), 75012 Paris, France. AD - Centre d'Investigation en Medecine du Sport, Assistance Publique-Hopitaux de Paris, Hotel-Dieu, 75004 Paris, France. FAU - Sedeaud, Adrien AU - Sedeaud A AUID- ORCID: 0000-0002-8492-3579 AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. AD - Institut National du Sport, de l'Expertise et de la Performance (INSEP), 75012 Paris, France. LA - eng PT - Journal Article DEP - 20260801 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Basketball/physiology MH - *Lasers MH - *Radar MH - Biomechanical Phenomena MH - Acceleration MH - *Running/physiology MH - Reproducibility of Results PMC - PMC13468825 OTO - NOTNLM OT - acceleration mechanics OT - athlete monitoring OT - indoor tracking OT - sprint profiling OT - team sports COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/01 CRDT- 2026/08/13 01:08 PHST- 2026/04/17 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:08 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - s26154845 [pii] AID - sensors-26-04845 [pii] AID - 10.3390/s26154845 [doi] PST - epublish SO - Sensors (Basel). 2026 Aug 1;26(15):4845. doi: 10.3390/s26154845. PMID- 42590224 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260815 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 15 DP - 2026 Aug 6 TI - Early Childhood Caries and Immunonutritional Status in Preschool Children: A Retrospective Comparative Study of the HALP Score and Hematological Biomarkers. LID - 10.3390/jcm15156122 [doi] LID - 6122 AB - Background: Early childhood caries (ECC) is a common chronic disease in children and has been associated with systemic inflammatory and nutritional alterations. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score reflects immunonutritional status. This study investigated the associations of the HALP score and hematological parameters with ECC, caries burden, and periapical disease severity. Methods: This retrospective comparative study included 126 preschool children: 97 with ECC and 29 caries-free controls. Participants were further classified into low (Periapical Index (PAI) 1-3) and high (PAI 4-5) periapical disease severity groups according to the highest Periapical Index score. The HALP score was calculated using the standard formula. Statistical significance was set at p < 0.05. Results: No statistically significant association was detected between the HALP score and ECC, dmft, or periapical disease severity (p > 0.05). Albumin levels were higher in the ECC group than in controls (p < 0.001). Neither the HALP score nor its individual hematological components were associated with caries burden in negative binomial regression analyses (p > 0.05). Greater caries burden was independently associated with severe periapical disease (Odds Ratio (OR) = 1.19, 95% Confidence Interval (CI): 1.09-1.30, p < 0.001), whereas hemoglobin was not (p = 0.052). Conclusions: No statistically significant association was detected between the HALP score and ECC status, caries burden, or periapical disease severity. Although albumin levels differed between children with ECC and caries-free controls, neither the HALP score nor its individual hematological components were independently associated with caries burden. Larger prospective multicenter studies are needed to validate these findings. FAU - Celikel, Peris AU - Celikel P AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Yaptirmis, Yesim AU - Yaptirmis Y AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Bilici, Elif AU - Bilici E AD - Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Ugurlu, Hacer Umay AU - Ugurlu HU AUID- ORCID: 0009-0009-7588-0851 AD - Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Ceylan, Erol Emir AU - Ceylan EE AUID- ORCID: 0000-0001-7927-3455 AD - Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Cetinkaya, Fuat AU - Cetinkaya F AD - Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Sengul, Fatih AU - Sengul F AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13467548 OTO - NOTNLM OT - albumins OT - biomarkers OT - child OT - dental caries OT - hemoglobin OT - pediatric dentistry COIS- The authors declare no competing interests. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/06 CRDT- 2026/08/13 01:06 PHST- 2026/07/12 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:06 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - jcm15156122 [pii] AID - jcm-15-06122 [pii] AID - 10.3390/jcm15156122 [doi] PST - epublish SO - J Clin Med. 2026 Aug 6;15(15):6122. doi: 10.3390/jcm15156122. PMID- 42590211 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260815 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 15 DP - 2026 Aug 6 TI - The Role of Wearable Devices in the Management of Congenital Heart Disease. LID - 10.3390/jcm15156111 [doi] LID - 6111 AB - Patients with congenital heart disease (CHD) represent a special healthcare challenge due to their high complexity, which accompanies them throughout all life stages. Consequently, this population faces increased morbidity and mortality rates, often linked to hemodynamic shifts in pulmonary flow or cardiac output. These risks are further compounded by potential arrhythmias and heart failure decompensation, which may lead to the progressive progression toward advanced stages of the disease. Unfortunately, standard outpatient follow-up is often not capable of responding to the continuous monitoring needs presented by these patients and their families. This selective review frames information on the wearable devices that have emerged as a key solution for continuous and remote monitoring. Beyond clinical tracking, research is increasingly focusing on their role in assessing physical activity-a critical determinant of health outcomes in the CHD population. This review examines the existing literature on wearable technology in both pediatric and adult patients while also addressing the current limitations that hinder their integration into routine clinical practice. FAU - Martinez-Saludes, Ines AU - Martinez-Saludes I AD - Cardiology Department, Hospital Clinic de Barcelona, 08036 Barcelona, Spain. FAU - Ruiz-Herguido, Cristina AU - Ruiz-Herguido C AUID- ORCID: 0000-0002-5133-3564 AD - Interdisciplinary Cardiovascular Research Group, Institut de Recerca Sant Joan de Deu, Santa Rosa 39-57, Esplugues de Llobregat, 08950 Barcelona, Spain. FAU - Toledo, Joan Sanchez de AU - Toledo JS AUID- ORCID: 0000-0002-9108-4750 AD - Interdisciplinary Cardiovascular Research Group, Institut de Recerca Sant Joan de Deu, Santa Rosa 39-57, Esplugues de Llobregat, 08950 Barcelona, Spain. AD - Cardiology Department, Sant Joan de Deu Barcelona Children's Hospital, Sant Joan de Deu 2, Esplugues de Llobregat, 08950 Barcelona, Spain. AD - Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA. FAU - Ferri-Rufete, David AU - Ferri-Rufete D AUID- ORCID: 0000-0001-6768-4759 AD - Interdisciplinary Cardiovascular Research Group, Institut de Recerca Sant Joan de Deu, Santa Rosa 39-57, Esplugues de Llobregat, 08950 Barcelona, Spain. AD - Cardiology Department, Sant Joan de Deu Barcelona Children's Hospital, Sant Joan de Deu 2, Esplugues de Llobregat, 08950 Barcelona, Spain. FAU - Montserrat, Silvia AU - Montserrat S AD - Cardiology Department, Hospital Clinic de Barcelona, 08036 Barcelona, Spain. FAU - Fernandez, David Vinas AU - Fernandez DV AD - Cardiology Department, Hospital Clinic de Barcelona, 08036 Barcelona, Spain. AD - Cardiology Department, Hospital General de Granollers, 08402 Granollers, Spain. AD - School of Medicine, Universitat Internacional de Catalunya, 08017 Barcelona, Spain. FAU - Flores-Umanzor, Eduardo AU - Flores-Umanzor E AD - Cardiology Department, Hospital Clinic de Barcelona, 08036 Barcelona, Spain. FAU - Luna-Lopez, Raquel AU - Luna-Lopez R AUID- ORCID: 0000-0002-1842-929X AD - Cardiology Department, Hospital Clinic de Barcelona, 08036 Barcelona, Spain. AD - Interdisciplinary Cardiovascular Research Group, Institut de Recerca Sant Joan de Deu, Santa Rosa 39-57, Esplugues de Llobregat, 08950 Barcelona, Spain. AD - Cardiology Department, Sant Joan de Deu Barcelona Children's Hospital, Sant Joan de Deu 2, Esplugues de Llobregat, 08950 Barcelona, Spain. LA - eng GR - PI24/00634/Instituto de Salud Carlos III (ISCIII)/ PT - Journal Article PT - Review DEP - 20260806 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13467547 OTO - NOTNLM OT - congenital heart disease OT - minutes of moderate-to-vigorous physical activity OT - monitoring sudden cardiac death OT - personalized medicine OT - telemedicine OT - usability OT - wearable COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/06 CRDT- 2026/08/13 01:06 PHST- 2026/06/11 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:06 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - jcm15156111 [pii] AID - jcm-15-06111 [pii] AID - 10.3390/jcm15156111 [doi] PST - epublish SO - J Clin Med. 2026 Aug 6;15(15):6111. doi: 10.3390/jcm15156111. PMID- 42589895 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260815 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 15 DP - 2026 Jul 24 TI - Strong Family-Level Clustering of Adolescent Weight Status Despite Limited Associations with Individual Parental Anthropometric and Metabolic Characteristics. LID - 10.3390/jcm15155790 [doi] LID - 5790 AB - Objectives: Familial aggregation of obesity has been consistently reported; however, previous studies have predominantly relied on body mass index (BMI)-based associations and have dedicated insufficient time to examining the contribution of measurable parental biological traits to family-level clustering. We investigated associations between parental anthropometric and metabolic characteristics and adolescent weight status in families in which at least one parent had obesity, while exploring family-level clustering patterns. Methods: This cross-sectional family-based study included 34 families comprising 110 individuals (65 parents and 45 adolescents) consecutively recruited from primary care registries. Participants underwent anthropometric and biochemical evaluation, including indices of central body fat distribution. Linear mixed models were used to investigate associations between parental characteristics and adolescent BMI percentile while accounting for non-independence of observations within families. Results: Mean parental BMI was 31.37 +/- 5.67 kg/m(2), while 61.5% of parents had obesity. Among adolescents, 28.9% had BMI percentile between the 85th and 95th percentiles and 13.3% had a BMI percentile > 95th percentile. Strong family-level clustering of adolescent weight status was consistently observed across analyses, with intraclass correlation coefficients ranging from 0.716 to 0.728. In contrast, parental characteristics demonstrated limited explanatory contribution (marginal R(2) 0.028-0.044), while no isolated parental variable showed a significant association with adolescent BMI percentile. Conclusions: Strong family-level clustering of adolescent weight status was observed despite the absence of significant associations with individual parental anthropometric and metabolic characteristics, suggesting that familial obesity susceptibility may reflect shared influences extending beyond routinely measurable traits alone. FAU - Mournos, Vasilios AU - Mournos V AD - Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Dimakopoulos, Georgios AU - Dimakopoulos G AUID- ORCID: 0000-0002-2351-7411 AD - BIOSTATS, Epirus Science and Technology Park Campus, University of Ioannina, 45110 Ioannina, Greece. FAU - Makridou, Theano AU - Makridou T AD - General Hospital of Veria, 59132 Veria, Greece. FAU - Kontotasios, Konstantinos AU - Kontotasios K AD - General Hospital of Veria, 59132 Veria, Greece. FAU - Pournaras, Dimitri J AU - Pournaras DJ AD - North Bristol NHS Trust, Bristol BS10 5NB, UK. AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1UD, UK. FAU - le Roux, Carel W AU - le Roux CW AUID- ORCID: 0000-0001-5521-5445 AD - School of Medicine, University College Dublin, DO4 V1W8 Dublin, Ireland. FAU - Kokkinos, Alexander AU - Kokkinos A AD - First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece. FAU - Kotsa, Kalliopi AU - Kotsa K AUID- ORCID: 0000-0003-2376-740X AD - Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece. FAU - Koufakis, Theocharis AU - Koufakis T AUID- ORCID: 0000-0002-5853-1352 AD - Second Propaedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration General Hospital, 49 Konstantinoupoleos Str., 54642 Thessaloniki, Greece. LA - eng PT - Journal Article DEP - 20260724 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13466985 OTO - NOTNLM OT - adolescent obesity OT - anthropometric characteristics OT - body mass index OT - family clustering COIS- DJP declares consulting fees from Johnson & Johnson, Novo Nordisk, Eli Lilly, Pfizer, GSK and Medtronic as well as honoraria from Johnson & Johnson, Medtronic, Sandoz and Novo Nordisk. ClR reports grants from the EU Innovative Medicine Initiative, Irish Research Council, Science Foundation Ireland, Anabio, and the Health Research Board. He serves on advisory boards and speakers panels of Abbvie, Altimmune, Amgen, Arrowhead Pharma, Astrazeneca, Boehringer Ingelheim, Eli Lily, Gila Pharmaceuticals, Herbalife, Irish Life Health, Johnson and Johnson, Keyron, Medscape, Metsera, Morphic Medical, Novo Nordisk, Nymble, Olympus, Pfizer, Rhythm Pharma, Roche, Wave, and Zealand Pharma. ClR is the Chair of the Irish Society for Nutrition and Metabolism. ClR received stock options as payment for scientific advisory board functions from Nymble. ClR provides obesity clinical care at the My Best Weight clinic and Beyond BMI clinic and is a co-owner of these clinics. AK reports research grants through his institution by Novo Nordisk Greece, Pharmaserve Lilly Greece, and ELPEN Pharma Greece. AK is on the speakers' bureau for Novo Nordisk Greece, Pharmaserve Lilly Greece, Astra Zeneca Greece, MSD Greece, Sanofi Greece, Bausch Health Greece, Ethicon Greece, Galenica Pharma Greece, Epsilon Health Greece, Winmedica Greece, and Viatris, and has consulting agreements with Novo Nordisk Greece, Pharmaserve Lilly Greece, Sanofi Greece, and Boehringer Ingelheim. TK has received honoraria for lectures from AstraZeneca, Sanofi, Boehringer Ingelheim, Pharmaserve Lilly, ELPEN, Menarini, and Novo Nordisk, for serving on advisory boards from Novo Nordisk, Roche Diagnostics, Sanofi, and Boehringer Ingelheim and has participated in sponsored studies by Eli-Lilly, AstraZeneca, and Novo Nordisk. The other authors declare that no conflicts of interest or financial relationships relevant to this article exist. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/07/24 CRDT- 2026/08/13 01:05 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:05 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - jcm15155790 [pii] AID - jcm-15-05790 [pii] AID - 10.3390/jcm15155790 [doi] PST - epublish SO - J Clin Med. 2026 Jul 24;15(15):5790. doi: 10.3390/jcm15155790. PMID- 42589146 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260815 IS - 2079-7737 (Print) IS - 2079-7737 (Electronic) IS - 2079-7737 (Linking) VI - 15 IP - 15 DP - 2026 Aug 4 TI - Potential Anticancer Activity of Donkey Milk in Human Gastric Adenocarcinoma (AGS) Cell Line. LID - 10.3390/biology15151279 [doi] LID - 1279 AB - Gastric cancer (GC) remains a major global health challenge, ranking among the most lethal malignancies due to late diagnosis, high tumor heterogeneity, and limited treatment efficacy. The search for safer, nutritionally based adjuncts to conventional therapies is therefore a research priority. Donkey milk (DM), traditionally used as a hypoallergenic substitute for infants, is emerging as a functional food with remarkable bioactivity. Its composition closely resembles human milk, with high levels of bioactive proteins, a favorable polyunsaturated lipid profile, antioxidant vitamins, and immune-supportive minerals. Despite its growing nutraceutical appeal, the anticancer potential of DM in GC has not yet been explored. This study represents the first investigation of DM in human gastric adenocarcinoma (AGS) cells. Using increasing concentrations of whole DM (25-100%), a dose-dependent inhibition of cell viability and migration was observed. Mechanistic insights reveal that DM induces mitochondrial oxidative stress, disrupts cell cycle progression (S/G2 accumulation at 75%, G2 arrest at 100%), and unexpectedly triggers a pro-inflammatory gene signature suggesting stress-driven immunostimulation rather than canonical apoptosis. These findings highlight a non-classical, context-dependent cytotoxic mechanism that distinguishes DM from conventional pro-apoptotic agents. DM may represent a promising nutraceutical candidate for GC management, bridging traditional food resources with modern oncology. By inhibiting hallmark cancer traits while engaging unique immunological pathways, DM offers a sustainable, low-toxicity approach with translational potential. Future studies will focus on the characterization of active components, validation in organoid and animal models, and exploring clinical applications of DM-derived bioactive components in cancer prevention and therapy. FAU - Mazzone, Mariangela AU - Mazzone M AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Di Marcantonio, Maria Carmela AU - Di Marcantonio MC AUID- ORCID: 0000-0001-9308-9857 AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Sindaco, Maria AU - Sindaco M AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Fatica, Antonella AU - Fatica A AUID- ORCID: 0000-0003-0207-089X AD - Department of Agricultural, Environmental and Food Sciences, University of Molise, 86100 Campobasso, Italy. FAU - Mencarelli, Noemi AU - Mencarelli N AUID- ORCID: 0009-0009-0423-5804 AD - Department of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Gallorini, Marialucia AU - Gallorini M AUID- ORCID: 0000-0002-2283-4159 AD - Department of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Cataldi, Amelia AU - Cataldi A AD - Department of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Muraro, Raffaella AU - Muraro R AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Salimei, Elisabetta AU - Salimei E AUID- ORCID: 0000-0001-9945-1458 AD - Department of Agricultural, Environmental and Food Sciences, University of Molise, 86100 Campobasso, Italy. FAU - Mincione, Gabriella AU - Mincione G AUID- ORCID: 0000-0001-7127-0938 AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. LA - eng GR - University "G. d'Annunzio" Chieti-Pescara/ PT - Journal Article DEP - 20260804 PL - Switzerland TA - Biology (Basel) JT - Biology JID - 101587988 PMC - PMC13465012 OTO - NOTNLM OT - adjunctive therapy OT - donkey milk OT - gastric cancer OT - nutraceutical agent COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/04 CRDT- 2026/08/13 01:04 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:04 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - biology15151279 [pii] AID - biology-15-01279 [pii] AID - 10.3390/biology15151279 [doi] PST - epublish SO - Biology (Basel). 2026 Aug 4;15(15):1279. doi: 10.3390/biology15151279. PMID- 42588200 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260827 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 6 TI - Is Phenylalanine Restricted Dietary Treatment in Phenylketonuria Associated with Disordered Eating: A Systematic Review. LID - 10.3390/nu18152576 [doi] LID - 2576 AB - Background: In phenylketonuria (PKU), the lifelong phenylalanine (Phe)-restricted diet may contribute to altered feeding behaviours and disordered eating. The true prevalence of disordered eating and eating disorders remains uncertain, partly because validated PKU-specific assessment tools are lacking. This systematic review aimed to identify, appraise, and synthesise the evidence on disordered eating and eating disorders in PKU. Methods: Four electronic databases (PubMed, Scopus, Web of Science, and Cochrane) were searched from inception to 24 February 2026. English-language studies reporting disordered eating or eating disorders in early-diagnosed individuals with PKU managed with a Phe-restricted diet, with or without drug therapy, were included. Studies of late- or never-treated patients, pregnancy, lactation, reviews, and preclinical studies were excluded. Two independent reviewers conducted study selection and data extraction. Outcomes included the prevalence of eating disorders, disordered eating behaviours and attitudes, associated factors, and the influence of drug treatment. Findings were synthesised qualitatively, and risk of bias was assessed using the NIH Study Quality Assessment Tools. Results: Twenty-four studies (2928 individuals with PKU) met the inclusion criteria. Most were observational or survey-based. Eating disorders were reported more frequently in PKU (3-13%) than in the general population (n = 4 studies). Common disordered eating features included food neophobia (n = 5 studies), limited food variety (n = 9), food aversion or refusal (n = 5), poor appetite (n = 5), prolonged mealtimes (n = 3), negative parent-child mealtime interactions (n = 6), and specific taste preferences (n = 5). Delayed feeding skill development (n = 6 studies), reduced social eating (n = 6), gastrointestinal symptoms (n = 8), and psychological or neurodevelopmental difficulties (n = 7) were also associated with disordered eating. Early feeding difficulties frequently persisted into adulthood, and longstanding eating behaviours did not consistently improve with pharmaceutical treatment (n = 6 studies). Most studies were rated as fair quality (19/24), with common limitations including small sample sizes, lack of sample-size justification, non-validated assessment tools, and absence of randomised controlled trials. Conclusions: Current evidence suggests that people with PKU experience a greater burden of eating-related difficulties than the general population, although robust estimates of eating disorder prevalence remain lacking. Existing screening tools may misclassify treatment-related dietary behaviours as pathological or fail to identify PKU-specific eating concerns. Development of PKU-specific screening tools could support routine clinical discussions about eating behaviours and the psychosocial impact of dietary treatment, facilitating earlier identification of individuals requiring specialist eating disorder assessment. (Prospero registration: CRD42024539600). FAU - Evans, Sharon AU - Evans S AUID- ORCID: 0000-0002-7654-3621 AD - Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. FAU - Ilgaz, Fatma AU - Ilgaz F AUID- ORCID: 0000-0002-6518-0255 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkey. FAU - MacDonald, Anita AU - MacDonald A AD - Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. LA - eng GR - Nutricia (United Kingdom)/ PT - Journal Article PT - Systematic Review DEP - 20260806 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 47E5O17Y3R (Phenylalanine) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - *Feeding and Eating Disorders/epidemiology/etiology/diet therapy MH - Feeding Behavior MH - *Phenylalanine/blood MH - *Phenylketonurias/diet therapy/complications/psychology MH - Prevalence MH - Diet, Protein-Restricted PMC - PMC13467740 OTO - NOTNLM OT - PKU OT - disordered eating OT - eating disorders OT - phenylketonuria COIS- The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. S.E. receives research funding from Vitaflo. F.I. declares no conflicts of interest in relation to this project. A.M. has received research or advisory board funding from Ajinomoto Cambrooke, Applied Pharma Research, Arla Food Ingredients, BioMarin Pharmaceutical, Galen Pharma, Ipsen Pharma, Jnana Therapeutics, MetaHealth, metaX, Nutricia, PIAM, PTC Therapeutics, and Vitaflo International. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/06 CRDT- 2026/08/13 01:02 PHST- 2026/06/22 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - nu18152576 [pii] AID - nutrients-18-02576 [pii] AID - 10.3390/nu18152576 [doi] PST - epublish SO - Nutrients. 2026 Aug 6;18(15):2576. doi: 10.3390/nu18152576. PMID- 42588180 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 5 TI - Body Composition Assessment in Pediatric Cystic Fibrosis in the Highly Effective Modulator Therapy Era-A Pilot Study. LID - 10.3390/nu18152557 [doi] LID - 2557 AB - Background/Objectives: The prevalence of obesity in cystic fibrosis (CF) has increased following the introduction of highly effective modulator therapy (HEMT). However, the impact of increased adiposity on the lung function of pediatric patients with CF (ppwCF) in the era of HEMT remains incompletely understood. Furthermore, while the body mass index (BMI) is the most commonly used nutritional marker in CF care, it has important limitations and may not accurately reflect body composition. Methods: In this cross-sectional pilot study, ppwCF aged 5-18 years completed Bioelectrical Impedance Analysis (BIA) while a subset completed a dual-energy X-ray absorptiometry (DXA) scan and spirometry. Normality was assessed using Shapiro-Wilk tests. Correlations, categorical association, agreement tests, Firth penalized logistic regression, and exploratory linear regression of continuous FEV1% predicted were used to examine relationships among anthropometric measurements, body compositions, and pulmonary function. Results: Thirty-four individuals completed study procedures (19 female (56%); mean age 9.85 (SD 3.58)). BIA and DXA-derived body fat percentages were strongly correlated, and categorical agreement was moderate (Cohen's Kappa 0.574; p-value 0.005). In age and sex-adjusted linear regression, BIA fat percentage (beta = -0.23; 95% CI, -1.09 to 0.64; p = 0.595) and DXA fat percentage (beta = -0.47; 95% CI, -2.14 to 1.21; p = 0.552) were not significantly associated with FEV1% predicted. Similarly, Firth logistic models showed no statistically significant association between the adiposity category and reduced lung function. Conclusions: BIA-derived body fat measurements correlate with DXA-derived measurements in ppwCF and demonstrate feasibility for use in routine CF clinic visits. This pilot cohort did not show a statistically significant relationship between higher adiposity and poorer pulmonary function. However, the wide confidence intervals indicate substantial uncertainty. Larger prospective studies are needed to evaluate longitudinal relationships between body composition and lung function in the HEMT era. FAU - Yavelow, Michelle AU - Yavelow M AUID- ORCID: 0000-0002-5660-8862 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of South Florida, Tampa, FL 33612, USA. AD - Division of Pediatric Pulmonology, Department of Pediatrics, University of South Florida, Tampa, FL 33620, USA. FAU - Tsalatsanis, Athanasios AU - Tsalatsanis A AUID- ORCID: 0000-0003-3818-8283 AD - Office of Research, Research Methodology and Biostatistics Core, University of South Florida, Tampa, FL 33612, USA. FAU - Couluris, Marisa AU - Couluris M AD - Division of Pulmonology, Department of Pediatrics, University of South Florida, Tampa, FL 33612, USA. FAU - Reynolds, Danielle AU - Reynolds D AD - USF Diabetes and Endocrinology Center, Health Informatics Institute, University of South Florida, Tampa, FL 33612, USA. FAU - Khalaf, Racha T AU - Khalaf RT AUID- ORCID: 0000-0001-5010-8149 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of South Florida, Tampa, FL 33612, USA. LA - eng GR - HSC-611900-22000-000000-0000000-8880153000/North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition/ PT - Journal Article DEP - 20260805 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Pilot Projects MH - Female MH - *Cystic Fibrosis/physiopathology/drug therapy/complications MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - *Body Composition MH - Absorptiometry, Photon MH - Electric Impedance MH - Child, Preschool MH - Body Mass Index MH - Adiposity MH - Spirometry PMC - PMC13468600 OTO - NOTNLM OT - bioelectrical impedance analysis OT - body composition OT - body mass index OT - cystic fibrosis OT - dual-energy X-ray absorptiometry OT - fat mass OT - lung function OT - modulator therapy OT - pediatrics COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/05 CRDT- 2026/08/13 01:02 PHST- 2026/06/26 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - nu18152557 [pii] AID - nutrients-18-02557 [pii] AID - 10.3390/nu18152557 [doi] PST - epublish SO - Nutrients. 2026 Aug 5;18(15):2557. doi: 10.3390/nu18152557. PMID- 42588178 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260827 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 5 TI - State-Level Promotion of Plant-Based School Meals in the United States: A National Policy Review. LID - 10.3390/nu18152556 [doi] LID - 2556 AB - Background: Pediatric cardiometabolic health in the United States is declining, driven by rising rates of obesity, prediabetes, and type 2 diabetes. School lunch programs provide a unique opportunity to influence children's dietary behaviors, reaching millions of students across diverse socioeconomic backgrounds each day. Increasing the availability of plant-based meals in school lunch programs may help reduce modifiable cardiometabolic risk factors and serve as a cost-effective, population-level strategy to promote long-term cardiovascular health. Methods: We conducted a cross-sectional narrative policy review of school lunch programs across all 50 U.S. states and the District of Columbia. Publicly available state statutes, regulations, school nutrition guidance, government reports, and educational resources were systematically reviewed to identify official statewide policies or guidance explicitly supporting plant-based or vegetarian meals. Jurisdictions were classified as providing either Explicit Support or Not Specified according to predefined coding criteria. We also assessed whether jurisdictions specified the frequency of plant-based meal offerings. Results: Only 3 of 51 jurisdictions (5.9%)-California, the District of Columbia, and Illinois-provided explicit statewide support for plant-based meal options. The remaining 48 jurisdictions (94.1%) did not explicitly promote or support plant-based meals in official statewide school nutrition policies or guidance. No jurisdiction mandated the frequency of plant-based meal offerings, although the District of Columbia provided non-binding guidance encouraging regular inclusion. Conclusions: Explicit statewide support for plant-based or vegetarian school meals remains rare in the United States. Strengthening state-level policies and developing standardized guidance on the inclusion and frequency of plant-based meals in school lunch programs may represent a feasible population-level strategy to improve dietary quality and reduce future pediatric cardiometabolic risk. FAU - Modak, Vishakha AU - Modak V AUID- ORCID: 0009-0002-1945-5817 AD - Jacobi Medical Center, Albert Einstein College of Medicine, New York City Health + Hospitals, 1400 Pelham Parkway, Bronx, NY 10461, USA. FAU - Karthikeyan, Aditya AU - Karthikeyan A AUID- ORCID: 0009-0006-5005-1211 AD - Jacobi Medical Center, Albert Einstein College of Medicine, New York City Health + Hospitals, 1400 Pelham Parkway, Bronx, NY 10461, USA. FAU - Sorajja, Natali AU - Sorajja N AUID- ORCID: 0000-0001-8399-4706 AD - Jacobi Medical Center, Albert Einstein College of Medicine, New York City Health + Hospitals, 1400 Pelham Parkway, Bronx, NY 10461, USA. FAU - Mangalesh, Sridhar AU - Mangalesh S AUID- ORCID: 0000-0002-2645-3994 AD - Jacobi Medical Center, Albert Einstein College of Medicine, New York City Health + Hospitals, 1400 Pelham Parkway, Bronx, NY 10461, USA. FAU - Shah, Priyansh AU - Shah P AD - Jacobi Medical Center, Albert Einstein College of Medicine, New York City Health + Hospitals, 1400 Pelham Parkway, Bronx, NY 10461, USA. FAU - Kaushik, Sharanya AU - Kaushik S AUID- ORCID: 0000-0002-3310-4792 AD - Jacobi Medical Center, Albert Einstein College of Medicine, New York City Health + Hospitals, 1400 Pelham Parkway, Bronx, NY 10461, USA. FAU - Gashi, Eleonora AU - Gashi E AD - Jacobi Medical Center, Albert Einstein College of Medicine, New York City Health + Hospitals, 1400 Pelham Parkway, Bronx, NY 10461, USA. FAU - Faillace, Robert AU - Faillace R AD - Jacobi Medical Center, Albert Einstein College of Medicine, New York City Health + Hospitals, 1400 Pelham Parkway, Bronx, NY 10461, USA. LA - eng PT - Journal Article PT - Review DEP - 20260805 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - United States MH - *Nutrition Policy MH - *Food Services/legislation & jurisprudence MH - *Schools MH - Child MH - Lunch MH - Cross-Sectional Studies MH - *Diet, Vegetarian MH - Diet, Plant-Based MH - *Health Promotion PMC - PMC13468650 OTO - NOTNLM OT - National School Lunch Program OT - USDA OT - cardiometabolic health OT - pediatric nutrition OT - plant-based diet OT - public health policy OT - school lunch OT - vegetarian COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/05 CRDT- 2026/08/13 01:02 PHST- 2026/06/14 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - nu18152556 [pii] AID - nutrients-18-02556 [pii] AID - 10.3390/nu18152556 [doi] PST - epublish SO - Nutrients. 2026 Aug 5;18(15):2556. doi: 10.3390/nu18152556. PMID- 42588169 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 4 TI - Plant-Derived Amino Acid-Based vs. Bovine-Derived Protein Human Milk Fortifiers in Preterm Infants at <34 Weeks' Gestation: An Open-Label Pilot Randomized Controlled Trial. LID - 10.3390/nu18152547 [doi] LID - 2547 AB - Background: Bovine milk protein-based human milk fortifiers (HMFs) are routinely used in preterm infants in low- and middle-income countries (LMICs) but are associated with potential adverse effects. Plant-derived amino acid-based HMFs are a promising alternative, but comparative data from randomized controlled trials (RCTs) are lacking. This pilot RCT aimed to evaluate the feasibility, safety, and growth outcomes of a novel plant-derived amino acid-based HMF compared to a bovine-derived whole-protein-based HMF in preterm infants at <34 weeks' gestation. Methods: In this open-label, parallel pilot RCT, preterm infants at <34 weeks' gestation were randomized to a plant-derived amino acid-based HMF (n = 66) or a bovine-derived whole-protein-based HMF (n = 70). Primary outcomes were time to reach 180 mL/kg/d enteral feeds and growth velocities to discharge and 40 weeks' postmenstrual age (PMA). Feasibility and safety were also assessed. The analysis followed an intention-to-treat approach. The trial was registered (CTRI/2025/06/089133). Results: Baseline characteristics were comparable between groups. Times to reach enteral feeds of 180 mL/kg/d did not differ (adjusted Hazard Ratio 0.93, 95% CI 0.65, 1.33; p = 0.70). In-hospital weight gain was significantly higher in the plant-derived HMF group (adjusted mean difference (aMD) 3.20 g/kg/d, 95% CI 0.46, 5.95; p = 0.02). This benefit was most evident in subgroup analyses of infants with birth weight >/=1500 g (aMD 4.47 g/kg/d, 95% CI 0.09, 8.84; p = 0.04). Length, head circumference growth, and all safety outcomes were similar between groups. Conclusions: The plant-derived amino acid-based HMF demonstrated clinical feasibility and was well-tolerated. While it was associated with better in-hospital weight gain, differences in overall macronutrient density between the formulations may account for this finding. These results are hypothesis-generating and warrant future adequately powered trials. FAU - Mudmal, Nikhil Kumar AU - Mudmal NK AD - Department of Neonatology, Ankura Hospital for Women and Children, Kukatpally, Hyderabad 500072, Telangana, India. FAU - Ramaswamy, Viraraghavan Vadakkencherry AU - Ramaswamy VV AUID- ORCID: 0000-0001-7092-3597 AD - Department of Neonatology, Ankura Hospital for Women and Children, Kukatpally, Hyderabad 500072, Telangana, India. AD - Department of Neonatology, Fernandez Foundation, Hyderguda, Hyderabad 500029, Telangana, India. FAU - Shaik, Nasreen Banu AU - Shaik NB AD - Department of Neonatology, Ankura Hospital for Women and Children, Kukatpally, Hyderabad 500072, Telangana, India. FAU - Basany, Laxman AU - Basany L AUID- ORCID: 0000-0002-4637-9007 AD - Department of Pediatrics, Ankura Hospital for Women and Children, L. B. Nagar, Hyderabad 500074, Telangana, India. AD - Department of Neonatology, Paramitha Women and Children's Hospital, L. B. Nagar, Hyderabad 500074, Telangana, India. FAU - Ali, Abid Ali Hasan AU - Ali AAH AUID- ORCID: 0009-0005-4769-7620 AD - Department of Pediatrics, Ankura Hospital for Women and Children, L. B. Nagar, Hyderabad 500074, Telangana, India. AD - Department of Pediatrics, Owaisi Hospital, Deccan College of Medical Sciences, Kanchan Bagh, Hyderabad 500058, Telangana, India. FAU - Ramya, V Sree AU - Ramya VS AD - Department of Neonatology, Ankura Hospital for Women and Children, Kukatpally, Hyderabad 500072, Telangana, India. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20260804 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Amino Acids) RN - 0 (Milk Proteins) SB - IM MH - Humans MH - Pilot Projects MH - Infant, Newborn MH - Animals MH - *Infant, Premature/growth & development MH - *Amino Acids/administration & dosage MH - Female MH - *Milk, Human/chemistry MH - *Food, Fortified MH - Gestational Age MH - Male MH - Cattle MH - *Milk Proteins/administration & dosage MH - Infant Nutritional Physiological Phenomena MH - Weight Gain MH - Enteral Nutrition MH - Feasibility Studies MH - *Infant Formula/chemistry PMC - PMC13467811 OTO - NOTNLM OT - amino acids OT - bovine HMF OT - enteral feed OT - human milk fortifier OT - neonatal nutrition OT - plant-based OT - preterm infant OT - randomized controlled trial COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/04 CRDT- 2026/08/13 01:02 PHST- 2026/04/02 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - nu18152547 [pii] AID - nutrients-18-02547 [pii] AID - 10.3390/nu18152547 [doi] PST - epublish SO - Nutrients. 2026 Aug 4;18(15):2547. doi: 10.3390/nu18152547. PMID- 42588145 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 4 TI - Sex-Specific Associations Between MTHFR, PPARG and ADRB3 Polymorphisms, Habitual Nutrient Intake and Metabolic Risk in Obesity: A Cross-Sectional Single-Centre Study. LID - 10.3390/nu18152522 [doi] LID - 2522 AB - Background/Objectives: Genetic polymorphisms modulate the risk of metabolic complications of obesity; yet, it remains unclear how genotype reshapes actual dietary intake and why these mechanisms differ between men and women. The aim of this study was to identify sex-specific associations of three common polymorphisms (MTHFR C677T, PPARG Pro12Ala, ADRB3 Trp64Arg) with habitual nutrient intake in patients with obesity, and to explore candidate sex-differentiated dietary hypotheses for future prospective testing. Methods: A single-centre cross-sectional study was performed in 348 patients with obesity (83 men, 265 women; BMI >/= 30 kg/m(2); age 18-60 years). Genotyping was performed by allele-specific real-time PCR from buccal swabs. Habitual intake of more than 18 nutrients was assessed using a standardised Russian software-based questionnaire. Statistical analysis included Kruskal-Wallis and Mann-Whitney tests with Bonferroni correction (threshold p < 0.017), as well as odds ratios (OR) with 95% confidence intervals. Genotype distributions were tested for Hardy-Weinberg equilibrium, and genotype-nutrient associations were additionally examined in models adjusted for age, BMI and total energy intake. Results: Three genotype-phenotype associations remained significant after Bonferroni correction. In men, the dominant-heterozygous MTHFR C/T genotype was associated with a hypercaloric dietary pattern-excess protein, fat, sodium and phosphorus-and with a high risk of arterial hypertension (OR 5.96, 95% CI 1.48-24.08; p = 0.010). The sodium load in C/T carriers was a consequence of overall overeating rather than a selective preference for salty foods. In men, ADRB3 Trp64Arg carriage was associated with massive dietary cholesterol overconsumption (+466% vs. +153% in Trp/Trp; p = 0.012), whereas in women the opposite direction was observed. The PPARG G/G genotype in women was associated with elevated alanine aminotransferase (p = 0.027), most pronounced under 40 years (p = 0.011), and is considered a marker of hepatic risk without a confirmed dietary target. In women, the MTHFR T/T homozygous genotype showed suggestive associations with excessive mono-/disaccharide intake and a tendency toward hypertension (OR 2.62, 95% CI 1.07-6.43; p = 0.035); however, these did not survive FDR correction and require independent validation. Conclusions: Genetic polymorphisms were associated with sex-specific patterns of actual dietary intake, a finding that extends current knowledge beyond biochemical risk associations. Based on these associations, we propose testable hypotheses rather than clinical recommendations: that caloric restriction (with consequent sodium reduction) in men with MTHFR C/T, cholesterol restriction in men with ADRB3 Arg64, and mono-/disaccharide restriction in women with MTHFR T/T might reduce metabolic risk; women with PPARG G/G may warrant ALT monitoring. These findings suggest that genotype-informed dietary strategies may need to be sex-specific, and that the window for intervention may be earlier in life than currently practised. However, these hypotheses require prospective interventional validation before any clinical application. FAU - Lapik, Irina A AU - Lapik IA AUID- ORCID: 0000-0002-0963-0792 AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Proyezd, Moscow 109240, Russia. FAU - Tarmaeva, Inna Yu AU - Tarmaeva IY AUID- ORCID: 0000-0001-7791-1222 AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Proyezd, Moscow 109240, Russia. FAU - Nikityuk, Dmitry B AU - Nikityuk DB AUID- ORCID: 0000-0002-4968-4517 AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Proyezd, Moscow 109240, Russia. AD - I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow 119991, Russia. LA - eng GR - FGMF-2026-0014/Federal Research Centre of Nutrition and Biotechnology/ PT - Journal Article DEP - 20260804 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (PPAR gamma) RN - 0 (Receptors, Adrenergic, beta-3) RN - 0 (ADRB3 protein, human) RN - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)) RN - EC 1.5.1.20 (MTHFR protein, human) SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - *PPAR gamma/genetics MH - *Obesity/genetics MH - *Receptors, Adrenergic, beta-3/genetics MH - Adolescent MH - *Methylenetetrahydrofolate Reductase (NADPH2)/genetics MH - Young Adult MH - Sex Factors MH - *Feeding Behavior MH - Genotype MH - *Polymorphism, Genetic MH - Genetic Predisposition to Disease MH - Risk Factors MH - Diet MH - Genetic Association Studies PMC - PMC13468027 OTO - NOTNLM OT - ADRB3 Trp64Arg OT - MTHFR C677T OT - PPARG Pro12Ala OT - arterial hypertension OT - habitual dietary intake OT - metabolic dysfunction-associated steatotic liver disease OT - nutrigenetics OT - obesity OT - personalised prevention OT - sex differences COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/04 CRDT- 2026/08/13 01:02 PHST- 2026/07/10 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - nu18152522 [pii] AID - nutrients-18-02522 [pii] AID - 10.3390/nu18152522 [doi] PST - epublish SO - Nutrients. 2026 Aug 4;18(15):2522. doi: 10.3390/nu18152522. PMID- 42588129 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 3 TI - Disordered Eating Attitudes in Hungarian Adults: Body Image, Sociocultural Media Pressures, and the Cross-Gender Athletic Ideal. LID - 10.3390/nu18152506 [doi] LID - 2506 AB - Background/Objectives: Appearance ideals are increasingly transmitted through digital media, reshaping the sociocultural context in which disordered eating develops. Central and Eastern European populations remain underrepresented in this literature. This study examined the prevalence of disordered eating attitudes in a Hungarian adult community sample and tested an integrated model of body image disturbance and media-transmitted sociocultural pressures as statistical predictors, including formal tests of mediation. Methods: Hungarian adults (N = 675; 70.8% female; aged 16-81 years, M = 44.09) completed the Eating Attitudes Test-26 (EAT-26), the Body Attitude Test (BAT), and the Sociocultural Attitudes Towards Appearance Questionnaire-3 (SATAQ-3) in an online survey; body mass index (BMI) was calculated from self-reported height and weight. All instruments demonstrated good to excellent internal consistency in the present sample (Cronbach's alpha = 0.84-0.93). Results: One in five participants (20.7%) scored at or above the EAT-26 clinical cut-off, with elevated rates at both extremes of the BMI spectrum (underweight: 30.0%; obese: 28.4%). Women scored higher than men on the EAT-26 (d = -0.59), BAT (d = -0.80), and three SATAQ-3 subscales; no gender difference emerged for athletic-ideal internalisation (d = -0.02), consistent with a cross-gender athletic ideal. The predictor set accounted for 40.5% of the variance in EAT-26 scores; BAT was the dominant predictor (beta = 0.61), while SATAQ-3 Athletic retained a direct path (beta = 0.08), and the remaining media-influence subscales lost significance once body image was controlled. A binary logistic regression using these predictors correctly classified 83.6% of participants (Nagelkerke R(2) = 0.35), with BAT and athletic-ideal internalisation again the only significant predictors of clinical-range classification. Bootstrapped mediation analyses confirmed that the associations between sociocultural influences and disordered eating attitudes were largely mediated by body image disturbance; only athletic-ideal internalisation retained a significant direct association (partial mediation). Conclusions: Body image disturbance constitutes the proximal core of disordered eating attitudes, whereas internalisation of the athletic ideal shows a small independent association, with implications for screening and prevention across the adult lifespan. FAU - Efthyvoulou, Lina AU - Efthyvoulou L AUID- ORCID: 0000-0003-0297-8777 AD - Department of Psychology, Neapolis University Pafos, 8042 Paphos, Cyprus. FAU - Dergez, Teodora AU - Dergez T AD - Faculty of Health Sciences, University of Pecs, 7622 Pecs, Hungary. FAU - Koushiou, Maria AU - Koushiou M AUID- ORCID: 0000-0002-5844-9906 AD - Department of Social Sciences, University of Nicosia, 2417 Nicosia, Cyprus. FAU - Argyrides, Marios AU - Argyrides M AUID- ORCID: 0000-0002-9936-7229 AD - Department of Psychology, Neapolis University Pafos, 8042 Paphos, Cyprus. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Hungarian people SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Body Image/psychology MH - Body Mass Index MH - Digital Media MH - Eastern European People MH - *Feeding and Eating Disorders/psychology/epidemiology MH - Hungary/epidemiology MH - Media Exposure MH - Prevalence MH - Sex Factors MH - Surveys and Questionnaires PMC - PMC13468281 OTO - NOTNLM OT - athletic ideal OT - body image OT - disordered eating OT - eating disorders OT - fitspiration OT - internalisation OT - mental health OT - nutrition OT - public health OT - social media COIS- M.A. serves as Guest Editor and M.K. as Guest Editor Assistant of the Special Issue "Eating Disorders, Body Image and Mental Health in a Digital World" of Nutrients; the manuscript underwent the journal's standard editorial process, handled independently of the Guest Editors. The authors declare no other conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/03 CRDT- 2026/08/13 01:02 PHST- 2026/07/02 00:00 [received] PHST- 2026/07/18 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - nu18152506 [pii] AID - nutrients-18-02506 [pii] AID - 10.3390/nu18152506 [doi] PST - epublish SO - Nutrients. 2026 Aug 3;18(15):2506. doi: 10.3390/nu18152506. PMID- 42588098 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Jul 30 TI - Effects of Three Consecutive Days of Diurnal Intermittent Fasting on Cognitive Function, Psychomotor Vigilance, and Sleep Quality in Adolescent Male Soccer Players: A Quasi-Experimental Parallel-Group Study. LID - 10.3390/nu18152475 [doi] LID - 2475 AB - Aim: While voluntary Islamic intermittent fasting (IF) of three consecutive days (mimicking practices such as Ayyam al-Bid) may be observed by Muslim athletes, its short-term effects on cognitive function and sleep quality in adolescent team-sport athletes remain unexamined. This study investigated the impact of three successive days of dawn-to-sunset IF on memory, attention, psychomotor vigilance, and subjective sleep quality in young male soccer players. Methods: A quasi-experimental, parallel-group design was employed. Thirty-five male soccer players (age: 15.6 +/- 0.8 years; body mass: 55.07 +/- 6.53 kg) were allocated to an IF group (n = 17) or a non-fasting control group (n = 18). The fasting protocol comprised approximately 14 consecutive hours of complete food and fluid abstinence per day (from 04:40 to 18:36, with daily variations of -3 min for the dawn and +2 min for the sunset, local time). Cognitive function was assessed using the CogniFit Cognitive Assessment Battery (CAB) and the Psychomotor Vigilance Test (PVT), and subjective well-being was quantified via the Hooper Index. Both assessment sessions were conducted between 14:00 and 17:00 to control for diurnal variation. Results: The Group x Time interaction for single-item subjective sleep quality reached nominal significance at the unadjusted threshold (Z = 2.18, p = 0.029, r = 0.37) but did not survive Bonferroni correction for the four Hooper Index comparisons (alpha = 0.0125); this result is therefore interpreted as hypothesis-generating only, reflecting a within-group deterioration in the control group (p < 0.05) alongside a non-significant marginal improvement in the fasting group. No statistically significant Group x Time interaction was detected for any memory subdomain (all p >/= 0.419, r 0.176, r 0.192, eta(2)p/r .073). Results support equivalence and feasibility of the remote APS for school-aged children with and without developmental differences. Recommendations for administration are discussed. FAU - Gordon, Rachel A AU - Gordon RA AUID- ORCID: 0000-0001-7566-6868 AD - Case Western Reserve University, Cleveland, OH. FAU - Doernberg, Ellen A AU - Doernberg EA AD - Boston Children's Hospital, Boston, MA. FAU - Dimitropoulos, Anastasia AU - Dimitropoulos A AD - Case Western Reserve University, Cleveland, OH. FAU - Russ, Sandra W AU - Russ SW AD - Case Western Reserve University, Cleveland, OH. LA - eng PT - Journal Article DEP - 20260225 PL - United States TA - Am J Intellect Dev Disabil JT - American journal on intellectual and developmental disabilities JID - 101492916 SB - IM MH - Humans MH - Child MH - Female MH - *Play and Playthings MH - *Autism Spectrum Disorder/diagnosis/physiopathology MH - Male MH - *Prader-Willi Syndrome/diagnosis/physiopathology MH - Telemedicine MH - *Affect/physiology MH - *Psychometrics/instrumentation OTO - NOTNLM OT - Affect in Play Scale OT - Prader-Willi Syndrome OT - Pretend play OT - assessment OT - autism spectrum disorder OT - telehealth EDAT- 2026/08/12 17:35 MHDA- 2026/08/12 17:36 CRDT- 2026/08/12 11:25 PHST- 2026/08/12 17:36 [medline] PHST- 2026/08/12 17:35 [pubmed] PHST- 2026/08/12 11:25 [entrez] AID - 10.1080/19447558.2026.2615614 [doi] PST - ppublish SO - Am J Intellect Dev Disabil. 2026;131(3):204-211. doi: 10.1080/19447558.2026.2615614. Epub 2026 Feb 25. PMID- 42583817 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260909 IS - 2054-1058 (Electronic) IS - 2054-1058 (Linking) VI - 13 IP - 8 DP - 2026 Aug TI - Prevalence of Kinesiophobia and Associated Factors Among Patients After Percutaneous Coronary Intervention: A Multicenter Cross-Sectional Study. PG - e70748 LID - 10.1002/nop2.70748 [doi] LID - e70748 AB - AIM: To investigate the prevalence and associated factors of kinesiophobia after percutaneous coronary intervention (PCI). DESIGN: A multicenter cross-sectional study. METHODS: We collected data of post-PCI patients who were recruited via convenience sampling from cardiology departments of eight tertiary hospitals between 1 November 2022 and 31 December 2023. Kinesiophobia was assessed by the Tampa Scale for Kinesiophobia Heart (TSK-SV Heart). Exercise self-efficacy, depression, anxiety, stress, and social support were evaluated by validated instruments. Participants' demographic and objective socioeconomic factors were also collected. Binary logistic regression analysis was conducted to identify the associated factors of kinesiophobia. RESULTS: Of 1145 recruited patients, 970 (84.72%) provided complete data and were included in the final analysis, of which 780 (80.41%) exhibited kinesiophobia. Factors significantly associated with kinesiophobia in the binary logistic regression analysis included: single status (vs. married: OR = 0.42, 95% CI: 0.22-0.79, p = 0.008), retired (vs. freelancers: OR = 1.89, 95% CI: 1.22-2.93, p = 0.004), had beyond 3 children (vs. 1 child: OR = 0.68, 95% CI: 0.46-0.99, p = 0.045), generally familiar with illness (vs. not familiar: OR = 2.00, 95% CI: 1.37-2.93, p < 0.001), comorbid hypertension (vs. no hypertension: OR = 1.49, 95% CI: 1.05-2.13, p = 0.028), participated in cardiac rehabilitation (vs. did not participate: OR = 1.52, 95% CI: 1.06-2.19, p = 0.023), moderate physical activity (vs. low: OR = 0.64, 95% CI: 0.42-0.97, p = 0.034), and high physical activity (vs. low: OR = 0.40, 95% CI: 0.25-0.65, p < 0.001) were significantly associated with kinesiophobia occurrence (p < 0.05). For each one-point increase in stress, anxiety, and objective support, the odds of kinesiophobia increased by 9% (OR = 1.09, 95% CI: 1.02-1.15, p = 0.008), 21% (OR = 1.21, 95% CI: 1.12-1.29, p < 0.001), and 9% (OR = 1.09, 95% CI: 1.01-1.19, p = 0.027), respectively. For each one-point increase in depression and SEE-C score, the odds of kinesiophobia decreased by 11% (OR = 0.89, 95% CI: 0.84-0.96, p = 0.001) and 1% (OR = 0.99, 95% CI: 0.98-0.99, p < 0.001), respectively. CONCLUSION: Kinesiophobia is highly prevalent among post-PCI patients. Identified associated factors include marital status, occupational status, number of children, illness familiarity, hypertension comorbidity, cardiac rehabilitation participation, physical activity level, levels of psychological distress, objective support, and exercise self-efficacy. These findings highlight potential targets for intervention. IMPLICATIONS FOR THE PROFESSION AND PATIENT CARE: Nurses should integrate routine kinesiophobia screening using the TSK-SV Heart scale into post-PCI assessment protocols. Risk-stratified screening should prioritize married or retired patients, those with fewer than three children, individuals with hypertension, and those with low baseline physical activity. For patients with low exercise self-efficacy, nurses can use motivational interviewing; for those with elevated anxiety or stress, collaborative cognitive-behavioural therapy is recommended. These nursing actions can reduce kinesiophobia and improve cardiac rehabilitation adherence. IMPACT: What problem did the study address? Kinesiophobia is a common but under-recognized barrier to cardiac rehabilitation in post-PCI patients, yet its prevalence and modifiable factors in Chinese populations remain poorly understood. What were the main findings? The prevalence of kinesiophobia was 80.41%. Independent associated factors included marital status, retirement, number of children, illness familiarity, hypertension, cardiac rehabilitation participation, physical activity level, anxiety, stress, depression, objective support, and exercise self-efficacy. Where and on whom will the research have an impact? The findings directly inform cardiac nursing practice in China and similar settings, enabling nurses to identify high-risk patients and implement targeted psychosocial interventions. REPORTING METHOD: This study adhered to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guideline for cross-sectional observational studies. PATIENT OR PUBLIC CONTRIBUTION: No patient or public contributed to the design, conduct, analysis, or interpretation of this study. TRIAL REGISTRATION: This observational study was registered in the Chinese Clinical Trial Registry (No. ChiCTR2300070396; https://www.chictr.org.cn/). CI - (c) 2026 The Author(s). Nursing Open published by John Wiley & Sons Ltd. FAU - Wang, Chunyuan AU - Wang C AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Hou, Xiaoqin AU - Hou X AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Zhang, Pian AU - Zhang P AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Liu, Caiyang AU - Liu C AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Yang, Yi AU - Yang Y AUID- ORCID: 0009-0000-2994-8346 AD - Department of Cardiology, Guangdong Provincial People's Hospital, Guangzhou, China. FAU - Zhao, Zhenhua AU - Zhao Z AD - Department of Cardiology, Guangdong Second Provincial People's Hospital, Guangzhou, China. FAU - Jiang, Weijun AU - Jiang W AD - Interventional Operating Room, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Su, Guanfu AU - Su G AD - Department of Cardiology, Huizhou Central People's Hospital, Huizhou, China. FAU - Jiang, Xiaofang AU - Jiang X AUID- ORCID: 0009-0003-6556-3226 AD - Department of Cardiology, Northern Guangdong People's Hospital, Shaoguan, China. FAU - Lin, Lijuan AU - Lin L AD - Department of Cardiology, Meizhou People's Hospital, Meizhou, China. FAU - Ning, Libing AU - Ning L AD - Department of Cardiology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. FAU - Lin, Lixia AU - Lin L AD - Department of Cardiology, Guangdong Provincial People's Hospital, Guangzhou, China. FAU - Zhan, Lechang AU - Zhan L AD - Department of Rehabilitation, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Zhan, Jie AU - Zhan J AUID- ORCID: 0000-0003-0220-3699 AD - Department of Rehabilitation, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. LA - eng GR - 2023HL11/the Hongmian project of GuangZhou First People's Hospital/ PT - Journal Article PT - Multicenter Study PT - Observational Study PL - United States TA - Nurs Open JT - Nursing open JID - 101675107 SB - IM MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Anxiety/psychology MH - Cross-Sectional Studies MH - *Kinesiophobia/epidemiology MH - *Percutaneous Coronary Intervention/psychology/adverse effects MH - Prevalence MH - Risk Factors MH - Surveys and Questionnaires PMC - PMC13463317 OTO - NOTNLM OT - exercise adherence OT - kinesiophobia OT - nursing assessment OT - percutaneous coronary intervention OT - psychological assessment OT - rehabilitation nursing COIS- Statistical Declaration Statement: The authors confirm that all statistical analyses in this study were performed appropriately. Data analysis was conducted using SPSSAU (version 26.0, https://www.spssau.com). The choice of statistical methods was guided by the nature of the data and the study objectives. Normality of continuous variables was assessed using the Shapiro-Wilk test, leading to the use of Mann-Whitney U test and Spearman correlation where appropriate. Categorical variables were analysed using the chi-square test. Binary logistic regression with stepwise selection was used to identify independent predictors of kinesiophobia, with results reported as odds ratios (ORs) and 95% confidence intervals (CIs). Multicollinearity was assessed using the variance inflation factor (VIF) and tolerance. Tolerance values > 0.1 (or VIF < 10) indicated no significant multicollinearity. Model fit was evaluated using the Hosmer-Lemeshow goodness-of-fit test. A non-significant p value (> 0.05) indicated adequate model fit. The overall model significance was tested using the likelihood ratio test comparing the final model to the null model. A two-sided p < 0.05 was considered statistically significant. AI Tools Acknowledgement: No generative artificial intelligence tools were used in the preparation of this manuscript. All writing, analysis, and interpretation were performed by the authors. The authors declare no conflicts of interest. EDAT- 2026/08/12 11:37 MHDA- 2026/08/12 11:38 PMCR- 2026/08/12 CRDT- 2026/08/12 07:32 PHST- 2026/07/30 00:00 [revised] PHST- 2024/12/24 00:00 [received] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/08/12 11:38 [medline] PHST- 2026/08/12 11:37 [pubmed] PHST- 2026/08/12 07:32 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - NOP270748 [pii] AID - 10.1002/nop2.70748 [doi] PST - ppublish SO - Nurs Open. 2026 Aug;13(8):e70748. doi: 10.1002/nop2.70748. PMID- 42582380 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260812 LR - 20260813 IS - 2673-3153 (Electronic) IS - 2673-3153 (Print) IS - 2673-3153 (Linking) VI - 8 DP - 2026 TI - Development and temporal validation of a prediction model for live birth in infertile women with polyendocrine metabolic ovarian syndrome: a retrospective cohort study. PG - 1891181 LID - 10.3389/frph.2026.1891181 [doi] LID - 1891181 AB - OBJECTIVE: To develop and temporally validate a prediction model for delivery of a live-born infant within 365 days after the initial infertility consultation in infertile women with a documented diagnosis of polycystic ovary syndrome (PCOS), which was renamed in 2026 as polyendocrine metabolic ovarian syndrome (PMOS), using routine clinical and basal endocrine variables. METHODS: This single-center retrospective cohort study included infertile women with a documented diagnosis of PCOS and an index date between December 1, 2021, and December 31, 2024. The index date was the first infertility consultation at which baseline clinical assessment and basal endocrine testing were completed. Patients were assigned to the development cohort (December 1, 2021-December 31, 2023) or the same-center temporal validation cohort (January 1-December 31, 2024). Outcome ascertainment ended on December 31, 2025. Multivariable logistic regression was used to predict delivery of a live-born infant within 365 days under routine individualized care. RESULTS: Among 610 women, 389 were in the development cohort and 221 in the temporal validation cohort. Live-birth proportions within 365 days were 44.7% and 44.3%, respectively. Complete-case model development and validation included 349 and 203 women, respectively. The final model included age, body mass index, infertility duration, gravidity, luteinizing hormone/follicle-stimulating hormone ratio, tubal/pelvic factors, and uterine factors. Older age (OR = 0.91, 95% CI: 0.85-0.98), higher body mass index (OR = 0.92, 95% CI: 0.86-0.98), longer infertility duration (OR = 0.85, 95% CI: 0.77-0.94), higher luteinizing hormone/follicle-stimulating hormone ratio (OR = 0.71, 95% CI: 0.55-0.91), and uterine factors (OR = 0.37, 95% CI: 0.15-0.80) were associated with lower live-birth probability. The AUCs were 0.735 and 0.738, and the Brier scores were 0.208 and 0.205, respectively. CONCLUSION: This model showed moderate discrimination and acceptable calibration for predicting delivery of a live-born infant within 365 days after initial infertility consultation. Multicenter external validation and impact studies are needed before broader clinical application. CI - (c) 2026 Liu, Wang, Lu, Jia, Geng, Cao, Han and Zhou. FAU - Liu, Peng AU - Liu P AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Wang, Shuhong AU - Wang S AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Lu, Yubo AU - Lu Y AD - School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China. FAU - Jia, Hanbing AU - Jia H AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Geng, Yue AU - Geng Y AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Cao, Cuijuan AU - Cao C AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Han, Le AU - Han L AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Zhou, Yingjie AU - Zhou Y AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. LA - eng PT - Journal Article DEP - 20260728 PL - Switzerland TA - Front Reprod Health JT - Frontiers in reproductive health JID - 9918230899006676 PMC - PMC13457464 OTO - NOTNLM OT - infertility OT - live birth OT - nomogram OT - polycystic ovary syndrome OT - polyendocrine metabolic ovarian syndrome OT - prediction model OT - temporal validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/12 11:38 MHDA- 2026/08/12 11:39 PMCR- 2026/07/28 CRDT- 2026/08/12 06:04 PHST- 2026/05/26 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/12 11:39 [medline] PHST- 2026/08/12 11:38 [pubmed] PHST- 2026/08/12 06:04 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 10.3389/frph.2026.1891181 [doi] PST - epublish SO - Front Reprod Health. 2026 Jul 28;8:1891181. doi: 10.3389/frph.2026.1891181. eCollection 2026. PMID- 42582369 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260812 LR - 20260813 IS - 0972-5229 (Print) IS - 1998-359X (Electronic) IS - 0972-5229 (Linking) VI - 30 IP - 7 DP - 2026 Jul TI - Change in Nutritional Status of Children in the Pediatric Intensive Care Unit over First 14 Days: A Prospective Cohort Study. PG - 595-600 LID - 10.5005/jp-journals-10071-25227 [doi] AB - BACKGROUND AND AIMS: We studied changes in nutritional status from baseline, as measured by serial skinfold thickness measurements and their association with patient factors, disease factors, and biochemical factors, as well as time to the start of enteral feeds. PATIENTS AND METHODS: We enrolled 50 consecutive children aged 2-5 years from the pediatric intensive care unit (PICU) of a public sector hospital in India between 14 February, 2024 and 31 August, 2024. Baseline demographic and clinical data were recorded. Serial anthropometric parameters were measured for all children at the time of admission (+4 hours), day 3, day 7, and day 14 or at hospital discharge, if earlier. We used the World Health Organization (WHO) growth charts to interpret the anthropometric data. RESULTS: Of the 50 children enrolled (mean age 3.17 +/- 1.22 years; 46% females), 58% were underweight, 52% had wasting, and 52% had short stature at admission. Only 10% children (n = 5) had triceps skinfold thickness for age <-2 standard deviation (SD) at baseline. 32 (64%) of the children demonstrated a reduction in triceps skinfold thickness, 72% (n = 36) experienced weight loss, and 58% (n = 29) showed a decrease in mid-upper arm circumference (MUAC). However, we did not find a statistically significant association of change in triceps skinfold thickness with age, severity of illness, outcome, duration of stay, and early start of enteral feeds. CONCLUSION: This study shows the feasibility of skinfold calipers as a serial monitoring tool in the PICU. Nutritional status worsens during the initial 2 weeks of PICU stay, despite early enteral feeding policies. CI - Copyright (c) 2026; The Author(s). FAU - Loyi, Morik AU - Loyi M AUID- ORCID: 0009-0002-4956-3392 AD - Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital (Delhi University), New Delhi, India. FAU - Mishra, Devendra AU - Mishra D AUID- ORCID: 0000-0002-6810-3095 AD - Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital (Delhi University), New Delhi, India. FAU - Jhamb, Urmila AU - Jhamb U AUID- ORCID: 0000-0003-1734-3504 AD - Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital (Delhi University), New Delhi, India. FAU - Saxena, Romit AU - Saxena R AUID- ORCID: 0000-0002-8518-5504 AD - Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital (Delhi University), New Delhi, India. LA - eng PT - Journal Article DEP - 20260721 PL - India TA - Indian J Crit Care Med JT - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine JID - 101208863 PMC - PMC13457648 OTO - NOTNLM OT - Critical illness OT - Enteral feeding OT - Malnutrition OT - Outcome OT - Triceps skinfold thickness OT - Wasting COIS- None.Source of support: Nil Conflict of interest: NoneConflict of interest: None EDAT- 2026/08/12 11:38 MHDA- 2026/08/12 11:39 PMCR- 2026/07/01 CRDT- 2026/08/12 06:03 PHST- 2025/06/04 00:00 [received] PHST- 2026/06/07 00:00 [accepted] PHST- 2026/08/12 11:39 [medline] PHST- 2026/08/12 11:38 [pubmed] PHST- 2026/08/12 06:03 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.5005/jp-journals-10071-25227 [doi] PST - ppublish SO - Indian J Crit Care Med. 2026 Jul;30(7):595-600. doi: 10.5005/jp-journals-10071-25227. Epub 2026 Jul 21. PMID- 42582338 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260812 LR - 20260813 IS - 2673-6101 (Electronic) IS - 2673-6101 (Print) IS - 2673-6101 (Linking) VI - 7 DP - 2026 TI - Food ladder use among ASCIA-affiliated clinicians in Australia and New Zealand: an exploratory descriptive survey. PG - 1889636 LID - 10.3389/falgy.2026.1889636 [doi] LID - 1889636 AB - BACKGROUND: Food ladders are clinician-guided graded dietary advancement tools used in selected patients with food allergy, but real-world implementation in Australia and New Zealand is not well described. OBJECTIVE: To characterise respondent-reported food ladder use and implementation patterns among ASCIA-affiliated clinicians in Australia and New Zealand. METHOD: We conducted a cross-sectional online survey of ASCIA-affiliated healthcare professionals from 1 to 30 June 2024. Invitations were distributed via the ASCIA email distribution list. Analyses were descriptive, with percentages calculated using valid-response denominators. RESULTS: Seventy clinicians participated: Australia 45/70 (64.3%) and New Zealand 25/70 (35.7%). Disciplines included allergy/immunology specialists (29/70, 41.4%), general paediatricians (13/70, 18.6%), nurses/nurse practitioners (10/70, 14.3%), dietitians (10/70, 14.3%), trainee doctors (7/70, 10.0%), and one general practitioner (1/70, 1.4%). Most primarily saw paediatric patients (53/70, 75.7%). Food ladder use was commonly reported among respondents (66/70, 94.3%). Among ladder users, most reported use in both IgE- and non-IgE-mediated contexts (47/66, 71.2%); milk (65/66, 98.5%) and egg (64/66, 97.0%) ladders predominated. Standardised ladders, recipes, and home introduction protocols were reported by 43/66 (65.2%), 43/66 (65.2%), and 45/66 (68.2%) respondents, respectively. Prior anaphylaxis to the proposed ladder food (51/66, 77.3%) and poorly controlled asthma (38/66, 57.6%) were the most frequently cited contraindications. In scenario responses, clinicians were least likely to recommend a ladder when there was prior anaphylaxis to the relevant food: milk 9/70 (12.9%) and egg 13/70 (18.6%). CONCLUSION: Among respondents, food ladder use was commonly reported, particularly for milk and egg allergy, with variability in implementation supports and in responses to higher-risk scenarios. These exploratory, self-reported findings are descriptive and hypothesis-generating. Together, they encourage further prospective evaluation and consensus-based standardisation. CI - (c) 2026 Nguyen, Tu, Hsiao, Peake and Pinzon-Charry. FAU - Nguyen, Alan AU - Nguyen A AD - Epworth Allergy Specialists, Epworth HealthCare, Richmond, VIC, Australia. AD - Population Allergy, Murdoch Children's Research Institute, Parkville, VIC, Australia. AD - Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia. FAU - Tu, Yiran AU - Tu Y AD - Queensland Paediatric Immunology and Allergy Service, Queensland Children's Hospital, South Brisbane, QLD, Australia. FAU - Hsiao, Kuang-Chih AU - Hsiao KC AD - Department of Immunology, Starship Child Health, Te Whatu Ora - Health New Zealand, Auckland, New Zealand. AD - Department of Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand. FAU - Peake, Jane AU - Peake J AD - Queensland Paediatric Immunology and Allergy Service, Queensland Children's Hospital, South Brisbane, QLD, Australia. AD - University of Queensland, St Lucia, QLD, Australia. FAU - Pinzon-Charry, Alberto AU - Pinzon-Charry A AD - Queensland Paediatric Immunology and Allergy Service, Queensland Children's Hospital, South Brisbane, QLD, Australia. AD - University of Queensland, St Lucia, QLD, Australia. AD - Griffith University, Nathan, QLD, Australia. LA - eng PT - Journal Article DEP - 20260728 PL - Switzerland TA - Front Allergy JT - Frontiers in allergy JID - 9918227355906676 PMC - PMC13457200 OTO - NOTNLM OT - ASCIA OT - IgE-mediated food allergy OT - egg ladder OT - food ladders OT - milk ladder OT - non-IgE-mediated food allergy OT - paediatrics OT - survey COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/12 11:38 MHDA- 2026/08/12 11:39 PMCR- 2026/07/28 CRDT- 2026/08/12 06:00 PHST- 2026/05/24 00:00 [received] PHST- 2026/06/28 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/12 11:39 [medline] PHST- 2026/08/12 11:38 [pubmed] PHST- 2026/08/12 06:00 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 10.3389/falgy.2026.1889636 [doi] PST - epublish SO - Front Allergy. 2026 Jul 28;7:1889636. doi: 10.3389/falgy.2026.1889636. eCollection 2026. PMID- 42580066 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260909 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 525 IP - Pt 4 DP - 2026 Oct 1 TI - Evaluation of glycoalkaloids and their aglycones in vegetable-based baby foods using a validated mesostructured silica-based MSPD protocol assisted by bead homogenization and UHPLC-MS/MS. PG - 150709 LID - S0308-8146(26)02869-4 [pii] LID - 10.1016/j.foodchem.2026.150709 [doi] AB - Glycoalkaloids (GAs) are a food safety concern in Solanaceae-derived products, but their occurrence in baby foods remains poorly documented. This study presents a sensitive, sustainable methodology for simultaneous determination of GAs and their aglycones in vegetable-based baby foods containing potato, eggplant, or tomato. Comparative evaluation of miniaturized ultrasound assisted (UA-MSPD), vortex assisted (VA-MSPD), and homogenizer assisted (HA-MSPD) matrix solid phase dispersion identified HA-MSPD as the most efficient strategy. Performance was improved using mesostructured silica MSU-2. Box-Behnken design optimized a rapid 30 s protocol with 5 mg sorbent, 125 mg sample, and 1 mL acidified methanol for simultaneous extraction and clean-up. The method exhibited excellent greenness (AGREEprep: 0.68) and reliable quantification of six GAs and two aglycones. Application to 23 commercial samples revealed total GAs up to 18 mg/kg, highlighting variability linked to raw material quality and underscoring the need for systematic monitoring of Solanaceae ingredients in infant foods. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Martinez-Garcia, Isabel AU - Martinez-Garcia I AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain; Instituto de Investigacion de Tecnologias para la Sostenibilidad, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain. FAU - Soto-Rangel, Lacey AU - Soto-Rangel L AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain; Departamento de Quimica Analitica, FACINET Universidad de Panama, Panama 3366, Panama. FAU - Perez-Quintanilla, Damian AU - Perez-Quintanilla D AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain. FAU - Morante-Zarcero, Sonia AU - Morante-Zarcero S AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain. Electronic address: sonia.morante@urjc.es. FAU - Sierra, Isabel AU - Sierra I AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain; Instituto de Investigacion de Tecnologias para la Sostenibilidad, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain. Electronic address: isabel.sierra@urjc.es. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260806 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 0 (Alkaloids) RN - 7631-86-9 (Silicon Dioxide) SB - IM MH - *Infant Food/analysis MH - *Vegetables/chemistry MH - *Food Contamination/analysis MH - Chromatography, High Pressure Liquid/methods MH - *Tandem Mass Spectrometry/methods MH - *Alkaloids/isolation & purification/chemistry/analysis MH - Silicon Dioxide/chemistry MH - *Solid Phase Extraction/methods/instrumentation MH - Humans MH - Solanum tuberosum/chemistry OTO - NOTNLM OT - Dietary exposure OT - Food contaminants OT - Green analytical chemistry OT - Infant nutrition OT - Risk assessment OT - Sustainable sample preparation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 23:35 MHDA- 2026/09/09 11:38 CRDT- 2026/08/11 18:07 PHST- 2026/04/01 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/08/11 23:35 [pubmed] PHST- 2026/08/11 18:07 [entrez] AID - S0308-8146(26)02869-4 [pii] AID - 10.1016/j.foodchem.2026.150709 [doi] PST - ppublish SO - Food Chem. 2026 Oct 1;525(Pt 4):150709. doi: 10.1016/j.foodchem.2026.150709. Epub 2026 Aug 6. PMID- 42579997 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260821 IS - 1753-6405 (Electronic) IS - 1326-0200 (Linking) VI - 50 IP - 4 DP - 2026 Aug TI - Staff and student acceptability and feasibility of an evidence-based integrated physical activity and mental wellbeing program in Australian secondary schools: A pilot study. PG - 100580 LID - S1326-0200(26)00269-4 [pii] LID - 10.1016/j.anzjph.2026.100580 [doi] AB - OBJECTIVE: To determine the acceptability, feasibility, perceived effectiveness and factors influencing the implementation of an evidence-based integrated physical activity and mental wellbeing program in Australian secondary schools. METHODS: A pilot study of a teacher-delivered 5-week physical activity and mental wellbeing program for Year 7 students was conducted in two New South Wales (NSW) schools. Surveys and focus groups collected teacher- and/or student-data regarding fidelity of implementation, acceptability, feasibility, usefulness, confidence to deliver, enjoyment, perceived effectiveness and factors influencing implementation. RESULTS: Seven teachers and 87 students participated. Both schools implemented all program components. Teachers reported that the program components were acceptable (40%-100%), feasible (71%), that the resources were useful (86%-100%) and confidence in delivering all components (71%-100%). Students reported that the program information was acceptable (74%-78%) and enjoyable (48%-62%). Teachers and students perceived positive student health and wellbeing impacts (40%-83%). Key teacher-reported factors influencing implementation were sufficient financial resources (86%) and recognition for program implementation (71%). Students suggested increasing active lessons relative to theoretical lessons, peer and teacher participation and lesson activity autonomy to improve participation. CONCLUSIONS: The integrated physical activity and mental wellbeing program was acceptable and feasible, and important factors to improve implementation and student participation were identified. IMPLICATIONS FOR PUBLIC HEALTH: Findings support a controlled study to assess effects on student health and wellbeing outcomes. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Hodder, Rebecca K AU - Hodder RK AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Hunter New England Population Health, Wallsend, NSW, Australia. Electronic address: Rebecca.Hodder@health.nsw.gov.au. FAU - Wrigley, Jessica AU - Wrigley J AD - Hunter New England Population Health, Wallsend, NSW, Australia. FAU - Ainsworth, Emma AU - Ainsworth E AD - Hunter New England Population Health, Wallsend, NSW, Australia; Northern Territory Health, Allied Health Service, Katherine, NT, Australia. FAU - McDiarmid, Katrina AU - McDiarmid K AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Hunter New England Population Health, Wallsend, NSW, Australia. FAU - O'Brien, Kate M AU - O'Brien KM AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Hunter New England Population Health, Wallsend, NSW, Australia. FAU - Nathan, Nicole AU - Nathan N AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Hunter New England Population Health, Wallsend, NSW, Australia. FAU - Bartlem, Kate AU - Bartlem K AD - Hunter New England Population Health, Wallsend, NSW, Australia; School of Psychological Sciences, the University of Newcastle, Callaghan, NSW, Australia. FAU - Groombridge, Daniel AU - Groombridge D AD - Hunter New England Population Health, Wallsend, NSW, Australia. CN - Healthy Children's Initiative Secondary School Advisory Group AD - Hunter New England Population Health, Wallsend, NSW, Australia. FAU - Clinton-McHarg, Tara AU - Clinton-McHarg T AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Melbourne School of Population and Global Health, the University of Melbourne, Parkville, VIC, Australia. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - Aust N Z J Public Health JT - Australian and New Zealand journal of public health JID - 9611095 SB - IM MH - Humans MH - Pilot Projects MH - Female MH - *Mental Health MH - *Exercise/psychology MH - *Students/psychology MH - *Health Promotion/methods MH - Feasibility Studies MH - Schools MH - Male MH - Adolescent MH - Psychological Well-Being MH - New South Wales MH - *School Health Services/organization & administration MH - Program Evaluation MH - Focus Groups MH - Child MH - *School Teachers/psychology MH - Surveys and Questionnaires MH - Australia OTO - NOTNLM OT - adolescent OT - health promotion OT - mental wellbeing OT - physical activity OT - schools COIS- Conflicts of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 23:35 MHDA- 2026/08/21 23:37 CRDT- 2026/08/11 18:05 PHST- 2024/12/03 00:00 [received] PHST- 2026/06/21 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/21 23:37 [medline] PHST- 2026/08/11 23:35 [pubmed] PHST- 2026/08/11 18:05 [entrez] AID - S1326-0200(26)00269-4 [pii] AID - 10.1016/j.anzjph.2026.100580 [doi] PST - ppublish SO - Aust N Z J Public Health. 2026 Aug;50(4):100580. doi: 10.1016/j.anzjph.2026.100580. Epub 2026 Aug 11. PMID- 42579937 OWN - NLM STAT- Publisher LR - 20260811 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 91 DP - 2026 Aug 11 TI - The mediating role of impulsivity in the relationship between multiple screen addiction and nighttime eating behaviors among adolescents. PG - 100-108 LID - S0882-5963(26)00372-6 [pii] LID - 10.1016/j.pedn.2026.08.003 [doi] AB - OBJECTIVE: This study examined whether impulsivity mediates the association between multiple screen addiction and nighttime eating behaviors among adolescents. METHODS: A cross-sectional design was used with 1247 adolescents recruited through purposive venue-based sampling with socioeconomic stratification in eastern Turkey province. Multiple screen addiction, impulsivity, and nighttime eating behaviors were assessed using validated self-report scales. A latent-variable structural equation model was tested, with age, gender, sleep duration, BMI z-score, and perceived socioeconomic status as covariates. Mediation was tested using bootstrap resampling (5000 resamples). RESULTS: Multiple screen addiction was positively associated with both impulsivity (beta = 0.272) and nighttime eating behaviors. Impulsivity partially mediated the association, accounting for approximately 28% of the total association, while the direct association between multiple screen addiction and nighttime eating behaviors remained the dominant pathway (approximately 72%). The structural model demonstrated acceptable fit (CFI = 0.924, RMSEA = 0.063, SRMR = 0.058). CONCLUSION: Impulsivity represents one partial mechanism linking multiple screen addiction to nighttime eating behaviors in adolescents. Pediatric and school health nurses may benefit from incorporating assessment of multiple screen addiction and self-regulation into routine adolescent care. Findings should be interpreted within the regional context of a single eastern Turkey province. IMPLICATIONS FOR NURSING PRACTICE: Interventions targeting adolescent health should adopt a multidimensional approach that includes screen time management, promotion of healthy eating habits, and strengthening self-regulation skills. Early identification of at-risk adolescents and development of school- and community-based nursing interventions may help prevent maladaptive behavioral patterns. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Evcimen, Hasan AU - Evcimen H AD - Mus Alparslan University, Department of Therapy and Rehabilitation Mus, Turkey. Electronic address: hsn_evcimen@hotmail.com. FAU - Bilgin, Sonay AU - Bilgin S AD - Ataturk University, Faculty of Nursing, Department of Public Health Nursing, Erzurum, Turkey. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM OTO - NOTNLM OT - Adolescent OT - Impulsivity OT - Multiple screen addiction OT - Nighttime eating OT - Structural equation modeling COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 23:35 MHDA- 2026/08/11 23:35 CRDT- 2026/08/11 18:01 PHST- 2026/04/14 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/08/11 23:35 [medline] PHST- 2026/08/11 23:35 [pubmed] PHST- 2026/08/11 18:01 [entrez] AID - S0882-5963(26)00372-6 [pii] AID - 10.1016/j.pedn.2026.08.003 [doi] PST - aheadofprint SO - J Pediatr Nurs. 2026 Aug 11;91:100-108. doi: 10.1016/j.pedn.2026.08.003. PMID- 42579393 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261007 IS - 1539-2570 (Electronic) IS - 0271-6798 (Linking) VI - 46 IP - 10 DP - 2026 Nov-Dec 01 TI - Is D-Dimer Associated With Disease Severity and Contralateral Slip Risk in Slipped Capital Femoral Epiphysis? PG - e1018-e1024 LID - 10.1097/BPO.0000000000003441 [doi] AB - BACKGROUND: To evaluate D-dimer levels in patients with slipped capital femoral epiphysis (SCFE), to investigate their association with disease severity and the development of contralateral slip, and to assess their contribution to existing predictive models. METHODS: In this single-center retrospective cohort study, 25 patients with unilateral SCFE diagnosed between January 2020 and April 2024 were included. The control group consisted of age- and sex-matched obese individuals and healthy subjects with normal body mass index (BMI). Clinical variables (age, sex, BMI, stability according to the Loder classification, and chronicity); laboratory parameters [complete blood count, neutrophil-to-lymphocyte ratio (NLR), inflammatory markers including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer]; and radiographic measurements [Southwick angle, interhip angle difference, posterior sloping angle (PSA), and modified Oxford bone score (MOBS)] were analyzed. Subgroup analyses based on stability and chronicity were performed, and correlations between D-dimer levels and clinical, laboratory, and radiographic parameters were assessed. Multivariable logistic regression models were constructed to predict contralateral slip, and model performance was evaluated using receiver operating characteristic (ROC) curve analysis. RESULTS: D-dimer levels were significantly higher in the SCFE group compared with both obese and healthy control groups ( P <0.001). D-dimer showed positive correlations with CRP and NLR and negative correlations with the MOBS and the interhip Southwick angle difference. Higher D-dimer levels were observed in unstable and acute-on-chronic cases ( P <0.001). During a mean follow-up of 24 months, patients who developed contralateral slip had significantly higher D-dimer levels ( P =0.002). The addition of Southwick angle difference to a baseline model including age and MOBS increased the AUC from 0.73 to 0.80, while further inclusion of D-dimer improved the AUC to 0.87. However, the increase in AUC after addition of D-dimer was not statistically significant according to the paired DeLong test ( P =0.18). CONCLUSION: D-dimer levels are associated with disease severity and the risk of contralateral slip in SCFE. Incorporation of D-dimer into established clinical and radiographic parameters improved predictive model performance. These findings support the role of inflammatory and microvascular processes in the pathogenesis of SCFE and suggest that D-dimer may serve as a useful adjunct biomarker for risk stratification. LEVELS OF EVIDENCE: Level III-retrospective cohort study. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Kurk, Muhammed B AU - Kurk MB AD - Department of Orthopaedics and Traumatology, Medical Park Maltepe Hospital. FAU - Albayrak, Kutalmis AU - Albayrak K AUID- ORCID: 0000-0002-8427-8856 AD - Department of Orthopaedics and Traumatology, University of Health Sciences Baltalimani Bone Diseases Training and Research Hospital. FAU - Aydin, Abdurrahman AU - Aydin A AUID- ORCID: 0000-0002-5570-9493 AD - Department of Orthopedics and Traumatology, Duzce Cagsu Hospital, Duzce, Turkey. FAU - Kayis, Gorkem AU - Kayis G AUID- ORCID: 0000-0002-8562-217 AD - Department of Orthopaedics and Traumatology, University of Health Sciences Baltalimani Bone Diseases Training and Research Hospital. FAU - Akpinar, Evren AU - Akpinar E AUID- ORCID: 0000-0002-0702-289 AD - Department of Orthopedics and Traumatology, Memorial Goztepe Hospital, Istanbul. AD - Department of Orthopaedics and Traumatology, ISTUN Istanbul Health and Technology University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - J Pediatr Orthop JT - Journal of pediatric orthopedics JID - 8109053 RN - 0 (Fibrin Fibrinogen Degradation Products) RN - 0 (fibrin fragment D) RN - 0 (Biomarkers) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - *Fibrin Fibrinogen Degradation Products/analysis/metabolism MH - *Slipped Capital Femoral Epiphyses/blood MH - Retrospective Studies MH - Female MH - Male MH - Severity of Illness Index MH - Biomarkers/blood MH - Child MH - Adolescent MH - Risk Factors MH - C-Reactive Protein OTO - NOTNLM OT - D-dimer OT - coagulation OT - contralateral slip OT - inflammation OT - risk prediction OT - slipped capital femoral epiphysis COIS- The authors declare no conflicts of interest. EDAT- 2026/08/11 17:36 MHDA- 2026/10/07 17:33 CRDT- 2026/08/11 12:13 PHST- 2026/04/24 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/10/07 17:33 [medline] PHST- 2026/08/11 17:36 [pubmed] PHST- 2026/08/11 12:13 [entrez] AID - 01241398-990000000-01274 [pii] AID - 10.1097/BPO.0000000000003441 [doi] PST - ppublish SO - J Pediatr Orthop. 2026 Nov-Dec 01;46(10):e1018-e1024. doi: 10.1097/BPO.0000000000003441. Epub 2026 Aug 11. PMID- 42579372 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260817 IS - 1540-8175 (Electronic) IS - 0742-2822 (Print) IS - 0742-2822 (Linking) VI - 43 IP - 8 DP - 2026 Aug TI - Pretreatment Coronary Ultrasound Radiomics Combined With the Prognostic Nutritional Index for Predicting IVIG Resistance in Children With Kawasaki Disease. PG - e70559 LID - 10.1111/echo.70559 [doi] LID - e70559 AB - BACKGROUND: Intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD) is associated with an increased risk of coronary artery injury and subsequent adverse cardiovascular outcomes. Early identification of patients at risk remains difficult in clinical practice. Conventional coronary ultrasound is largely based on geometric parameters, such as luminal diameter and Z scores, and may not fully capture local heterogeneity within coronary images. In this study, we investigated whether pretreatment coronary artery ultrasound radiomics could improve early identification of IVIG resistance in children with KD. We further developed a multimodal prediction model incorporating radiomics, the prognostic nutritional index (PNI), and clinical characteristics. METHODS: A total of 352 children diagnosed with KD and treated at The First Affiliated Hospital of Guangxi Medical University between January 2020 and January 2026 were retrospectively included. All patients received standardized treatment after diagnosis. Demographic characteristics, pretreatment laboratory results, conventional coronary ultrasound parameters, and two-dimensional static ultrasound images of the left coronary artery (LCA), left anterior descending artery (LAD), and right coronary artery (RCA) were collected. The pretreatment two-dimensional static coronary ultrasound images were imported into 3D Slicer for region-of-interest segmentation. A clinical prediction model was constructed using multivariable logistic regression. PNI was defined a priori as the primary nutritional-immunologic indicator. In addition, the potential incremental predictive value of other nutritional-inflammatory indices, including the C-reactive protein-to-albumin ratio (CAR), neutrophil-to-albumin ratio (NAR), neutrophil percentage-to-albumin ratio (NPAR), and C-reactive protein-albumin-lymphocyte (CALLY) index, was further evaluated. Radiomics features were selected through repeated segmentation, intraclass correlation coefficient (ICC)-based stability filtering, correlation filtering, and least absolute shrinkage and selection operator (LASSO) regression. The Clinic, Clinic + PNI, Radiomics, and Clinic + PNI + Radiomics models were assessed using receiver operating characteristic curves, DeLong tests, calibration curves, decision curve analysis, and Shapley Additive Explanations (SHAP) interpretation. The Kobayashi, Egami, and Sano scores were evaluated in the same training and validation cohorts. RESULTS: Among the 352 children, 57 (16.2%) were classified as IVIG resistant. Multivariable analysis showed that higher pretreatment maximum coronary artery Z score (Z(max)), longer fever duration, and higher neutrophil count were associated with an increased risk of IVIG resistance. In the validation cohort, the Clinic + PNI model showed favorable discriminatory ability, with an AUC of 0.855 (95% CI, 0.767-0.911), a sensitivity of 0.882, and a negative predictive value of 0.969. Seven radiomics features were selected and used to construct the radiomics score (Rad-score). In the training cohort, the Clinic + PNI + Radiomics model achieved higher AUC values than the Clinic, Clinic + PNI, and Radiomics models. This pattern was also observed in the validation cohort, where the integrated model achieved the highest AUC of 0.880 (95% CI, 0.817-0.944), although the between-model differences did not reach statistical significance. Decision curve analysis showed that the integrated model offered a favorable net benefit within clinically meaningful threshold ranges. SHAP analysis suggested that its predictions reflected the joint influence of systemic inflammatory burden, nutritional and immune status, and local imaging heterogeneity captured from coronary ultrasound images. The Kobayashi, Egami, and Sano scores yielded validation AUCs of 0.616, 0.567, and 0.449, respectively. CONCLUSIONS: Pretreatment coronary ultrasound radiomics may provide complementary information to conventional clinical, laboratory, and ultrasonographic parameters for assessing the risk of IVIG resistance in children with KD. By integrating inflammatory burden, nutritional-immunologic status, and local coronary imaging heterogeneity, the Clinic + PNI + Radiomics model showed favorable discrimination and potential clinical net benefit in internal validation. However, its incremental value and clinical applicability require further confirmation in external cohorts. CI - (c) 2026 Wiley Periodicals LLC. FAU - Xiao, Caiyi AU - Xiao C AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Chen, Chaorong AU - Chen C AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Huang, Yuanyuan AU - Huang Y AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Wei, Xianbin AU - Wei X AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Li, Bin AU - Li B AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Wu, Jing AU - Wu J AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Huang, Huiying AU - Huang H AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Su, Dunhui AU - Su D AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Zhang, Bulin AU - Zhang B AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Wu, Ji AU - Wu J AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. LA - eng PT - Journal Article PL - United States TA - Echocardiography JT - Echocardiography (Mount Kisco, N.Y.) JID - 8511187 RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Humans MH - *Mucocutaneous Lymph Node Syndrome/drug therapy MH - Male MH - Female MH - Radiomics MH - Retrospective Studies MH - Prognosis MH - Child, Preschool MH - *Drug Resistance MH - *Immunoglobulins, Intravenous/therapeutic use MH - *Coronary Vessels/diagnostic imaging MH - *Nutrition Assessment MH - *Echocardiography/methods MH - Ultrasonography/methods MH - Infant PMC - PMC13460361 OTO - NOTNLM OT - IVIG resistance OT - Kawasaki disease OT - coronary artery ultrasound OT - prediction model OT - prognostic nutritional index OT - radiomics COIS- The authors declare no conflicts of interest. EDAT- 2026/08/11 17:36 MHDA- 2026/08/11 17:37 PMCR- 2026/08/11 CRDT- 2026/08/11 12:04 PHST- 2026/07/01 00:00 [revised] PHST- 2026/05/05 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/08/11 17:37 [medline] PHST- 2026/08/11 17:36 [pubmed] PHST- 2026/08/11 12:04 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - ECHO70559 [pii] AID - 10.1111/echo.70559 [doi] PST - ppublish SO - Echocardiography. 2026 Aug;43(8):e70559. doi: 10.1111/echo.70559. PMID- 42579007 OWN - NLM STAT- Publisher LR - 20260811 IS - 2366-0058 (Electronic) DP - 2026 Aug 11 TI - A simplified MRI‑based risk score and nomogram to predict initial objective response in unresectable hepatocellular carcinoma treated with HAIC, targeted therapy, and immunotherapy: a multicenter study. LID - 10.1007/s00261-026-05732-6 [doi] AB - PURPOSE: This study aimed to develop and validate a simplified risk score based on pretreatment Gd‑EOB‑DTPA MRI features for the noninvasive prediction of initial objective response rate (ORR) in patients with unresectable hepatocellular carcinoma (uHCC) undergoing triple therapy (hepatic arterial infusion chemotherapy [HAIC], tyrosine kinase inhibitors, and immune checkpoint inhibitors). METHODS: This retrospective study enrolled 223 uHCC patients from two medical centers who underwent Gd‑EOB‑DTPA‑enhanced MRI prior to initiating triple therapy (training set: n = 127; external test set: n = 96). Imaging features were evaluated and extracted. Independent predictors of initial ORR were identified by multivariate logistic regression to build a simplified imaging risk score (I-score), and a nomogram was constructed to visualize the final predictive model. Model performance was assessed by AUC, calibration (Hosmer‑Lemeshow test), confusion matrix, and decision curve analysis (DCA), with internal bootstrap and external validation. SHAP analysis provided interpretability. Patients were stratified into low‑ and high‑risk groups, and Kaplan‑Meier curves for progression‑free survival (PFS) and overall survival (OS) were compared. RESULTS: Three MRI features (irregular morphology, rim enhancement, peritumoral low signal) were independent negative predictors of initial ORR. The simplified I-score was formulated as: 1x(irregular morphology) + 1 x (rim enhancement) + 2 x (peritumoral low signal), with an optimal cut-off of 1.5. Following LASSO regression, BMI > 22.55, PA < 182.5 mg/L, NLR > 2.37, and I-score >/= 2 were included in the nomogram. The nomogram achieved AUCs of 0.890 in training and 0.841 in validation for ORR prediction, demonstrating good calibration (P > 0.05) and clinical benefit. SHAP analysis identified I-score as the most important contributor. The model significantly outperformed BCLC, ALBI, Child‑Pugh, and Six‑and‑Twelve staging systems (all P < 0.05). High‑risk patients had significantly worse PFS and OS than low‑risk patients. CONCLUSION: The MRI‑based simplified risk score and the derived nomogram offer a noninvasive and precise method for predicting initial ORR and classifying prognosis in uHCC patients undergoing triple therapy. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Wang, Yi-Kang AU - Wang YK AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Feng, Hua-Guo AU - Feng HG AD - Chongqing Red Cross Hospital, Chongqing, China. FAU - Liu, Yan-Han AU - Liu YH AD - Chongqing University Jiangjin Hospital, Chongqing, China. FAU - Zhang, Chun-Yu AU - Zhang CY AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhou, Xue AU - Zhou X AD - Chongqing University Jiangjin Hospital, Chongqing, China. FAU - Liu, Hai-Ling AU - Liu HL AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. 980956941@qq.com. FAU - Liu, Zuo-Jin AU - Liu ZJ AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. 300376@hospital.cqmu.edu.cn. FAU - Tan, Hao-Yang AU - Tan HY AUID- ORCID: 0000-0001-5739-378X AD - Chongqing University Jiangjin Hospital, Chongqing, China. 13609454209@163.com. LA - eng GR - 82504160/National Natural Science Foundation of China/ GR - 82370672/National Natural Science Foundation of China/ GR - BX20250259/China Postdoctoral Science Foundation/ GR - 2025YCXM010/Chongqing University Jiangjin Hospital Internal Cultivation Project/ PT - Journal Article DEP - 20260811 PL - United States TA - Abdom Radiol (NY) JT - Abdominal radiology (New York) JID - 101674571 SB - IM OTO - NOTNLM OT - Hepatic arterial infusion chemotherapy OT - Hepatocellular carcinoma OT - Imaging scores OT - Initial objective response OT - Magnetic resonance imaging COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:37 CRDT- 2026/08/11 11:05 PHST- 2026/01/07 00:00 [received] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/08/11 12:37 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 11:05 [entrez] AID - 10.1007/s00261-026-05732-6 [pii] AID - 10.1007/s00261-026-05732-6 [doi] PST - aheadofprint SO - Abdom Radiol (NY). 2026 Aug 11. doi: 10.1007/s00261-026-05732-6. PMID- 42578774 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260811 IS - 2724-7031 (Electronic) IS - 0041-4131 (Linking) VI - 104 IP - 4 DP - 2026 May 1 TI - Chronic pain among patients treated for breast cancer: Prevalence and associates factors. PG - 678-682 LID - 10.62438/tunismed.v104i05.6520 [doi] AB - OBJECTIVES: Chronic pain has emerged as a significant health issue among women treated for breast cancer, representing a substantial burden that negatively affects quality of life. This study aimed to determine the prevalence and characteristics of chronic pain among Tunisian breast cancer survivors. METHODS: We conducted a cross-sectional descriptive and analytical study including 100 Tunisian women treated for breast cancer at the Medical Oncology Department of Fattouma Bourguiba University Hospital (Monastir, Tunisia). Data collected included sociodemographic and clinical characteristics, lifestyle habits, and medical history. Validated instruments were used, including the Brief Pain Inventory (BPI), Pain Catastrophizing Scale (PCS), DN4 questionnaire, Hospital Anxiety and Depression Scale (HADS), and Family APGAR score. RESULTS: The prevalence of chronic pain in our population was 100%. All participants reported persistent pain following breast cancer surgery, without any other identified medical cause. The most common pain locations were the breast and ipsilateral upper limb. Pain interference was generally mild in both affective and activity domains. Most participants (88%) belonged to highly functional families. Higher pain intensity was significantly associated with a greater number of children and a history of dysthyroidism. Multivariate analysis identified body mass index, number of children, and number of lymph nodes removed as independent predictors of pain intensity. Higher pain intensity was also associated with increased anxiety levels. CONCLUSIONS: Chronic pain is highly prevalent among breast cancer survivors and is influenced by multiple factors, highlighting the need for comprehensive assessment and management strategies. FAU - Khechine, Wiem AU - Khechine W AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Chouat, Marwa AU - Chouat M AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Hmad, Alaeddine AU - Hmad A AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Amamou, Badii AU - Amamou B AD - Department of Psychiatry, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Felfoul, Asma AU - Felfoul A AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Korbi, Asma AU - Korbi A AD - Department of Gynecology and Obstetrics, Maternity and neonatology center, Monastir, Tunisia. FAU - Jebali, Fethi AU - Jebali F AD - Department of Anesthesiology, Maternity and neonatology center, Monastir, Tunisia. FAU - Zaied, Sonia AU - Zaied S AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Daldoul, Amira AU - Daldoul A AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. LA - eng PT - Journal Article DEP - 20260501 PL - Tunisia TA - Tunis Med JT - La Tunisie medicale JID - 0413766 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Breast Neoplasms/complications/epidemiology/therapy/surgery MH - Prevalence MH - *Chronic Pain/epidemiology/etiology MH - Tunisia/epidemiology MH - Middle Aged MH - Adult MH - Quality of Life MH - Aged MH - Pain Measurement MH - Mastectomy/adverse effects MH - Cancer Survivors/statistics & numerical data MH - Surveys and Questionnaires MH - Risk Factors OTO - NOTNLM OT - Breast cancer survivors OT - Breast conserving surgery OT - Chronic pain OT - Mastectomy OT - Quality of life EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 CRDT- 2026/08/11 09:52 PHST- 2025/10/12 00:00 [received] PHST- 2026/04/12 00:00 [accepted] PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 09:52 [entrez] AID - /article/view/6520 [pii] AID - 10.62438/tunismed.v104i05.6520 [doi] PST - epublish SO - Tunis Med. 2026 May 1;104(4):678-682. doi: 10.62438/tunismed.v104i05.6520. PMID- 42578713 OWN - NLM STAT- Publisher LR - 20260811 IS - 1668-3501 (Electronic) IS - 0325-0075 (Linking) DP - 2026 Aug 13 TI - Differences in psychomotor development among preschool children according to the type of early childhood education institution in Temuco, Chile. PG - e202510950 LID - 10.5546/aap.2025-10950.eng [doi] AB - Introduction. Psychomotor development is an essential indicator of child growth that integrates cognitive, motor, linguistic, and socio-emotional dimensions. Objective. To evaluate the association between the type of educational institution and psychomotor development in preschoolers. Population and methods. A cross-sectional analytical study was conducted in 2019 among children aged 2 to 4 years attending public and private preschools. Psychomotor development was assessed using the Test of Child Learning and Development (TADI, by its Spanish acronym), validated in Chile. Multinomial logistic regression was performed, adjusting for socioeconomic status, maternal education, and the child's age, sex, and nutritional status. Results. A total of 151 children were included; 52.7% of the participants were girls, and the mean age was 40 +/- 8.1 months. An association was observed between attending public facilities and a classification of risk or delay in global psychomotor development (OR = 7.34; 95%CI: 1.65-32.58; p <0.05) and cognitive development (OR = 10.83; 95%CI: 1.64-71.59; p <0.05), compared with private facilities. Male gender was associated with increased risk of, or delay in, global psychomotor development (OR = 6.53; 95%CI: 1.94-22.08), cognitive development (OR = 4.45; 95%CI: 1.41-13.99), and motor development (OR = 3.07; 95%CI: 1.17-8.08). Conclusion. The type of educational setting and gender were associated with differences in psychomotor development among preschoolers. The findings should be interpreted with consideration of possible sociodemographic and contextual factors that were not fully captured. CI - Sociedad Argentina de Pediatria. FAU - Lavados-Romo, Pamela AU - Lavados-Romo P AUID- ORCID: 0000-0002-6799-798X AD - Department of Preclinical Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. AD - Center for Research in Cardiometabolic and Nutritional Epidemiology (EPICYN, by its Spanish acronym), School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Andrade-Mayorga, Omar AU - Andrade-Mayorga O AD - Department of Preclinical Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. AD - Center for Research in Cardiometabolic and Nutritional Epidemiology (EPICYN, by its Spanish acronym), School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Luza, Nelly AU - Luza N AD - Department of Preclinical Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Toloza-Torres, Leonardo AU - Toloza-Torres L AD - Department of Rehabilitation Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Bahamondes, Ornella AU - Bahamondes O AD - Department of Rehabilitation Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Mella, Camila AU - Mella C AD - Department of Physical Education, Sports, and Recreation, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Espejo Mandujano, Valentina AU - Espejo Mandujano V AD - Pediatrics, Universidad de La Frontera, Dr. Hernan Henriquez Aravena Hospital, Temuco, Chile. FAU - Vasquez, Paulina AU - Vasquez P AD - Department of Diagnostic Processes and Evaluation, School of Health Sciences, Universidad Catolica de Temuco, Chile. FAU - Lubini Fuica, Giancarlo AU - Lubini Fuica G AD - Medical Program, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Pinto-Morales, Francisca AU - Pinto-Morales F AD - Trovolhue Family Health Center, Municipal Health Department, Carahue, Chile. FAU - Balboa-Castillo, Teresa AU - Balboa-Castillo T AD - Center for Research in Cardiometabolic and Nutritional Epidemiology (EPICYN, by its Spanish acronym), School of Medicine, Universidad de La Frontera, Temuco, Chile. AD - Department of Public Health, School of Medicine, Universidad de La Frontera, Temuco, Chile. LA - eng LA - spa PT - Journal Article TT - Diferencias en el desarrollo psicomotor infantil en preescolares segun el tipo de establecimiento de educacion inicial en Temuco, Chile. DEP - 20260813 PL - Argentina TA - Arch Argent Pediatr JT - Archivos argentinos de pediatria JID - 0372460 SB - IM OTO - NOTNLM OT - growth and development OT - neurodevelopment OT - preschool education OT - private sector OT - public sector EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:37 CRDT- 2026/08/11 09:20 PHST- 2026/08/11 12:37 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 09:20 [entrez] AID - 10.5546/aap.2025-10950.eng [doi] PST - aheadofprint SO - Arch Argent Pediatr. 2026 Aug 13:e202510950. doi: 10.5546/aap.2025-10950.eng. PMID- 42578573 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 1460-2210 (Electronic) IS - 0141-5387 (Print) IS - 0141-5387 (Linking) VI - 48 IP - 5 DP - 2026 Aug 6 TI - Automated prediction of hand-wrist maturation stage from lateral cephalometric and panoramic radiographs using a deep learning approach. LID - 10.1093/ejo/cjag054 [doi] LID - cjag054 AB - OBJECTIVES: This study aimed to predict hand-wrist developmental stages, the most reliable indicator of skeletal maturation, from panoramic radiographs (PRs) and lateral cephalometric radiographs (LCRs) using deep learning and to compare the two methods. The goal was to provide a rapid and objective method for growth assessment in orthodontic planning without additional radiation exposure. METHODS: A total of 3703 patients who underwent hand-wrist radiographs (HWRs), PRs, and LCRs prior to orthodontic treatment were retrospectively analyzed. HWRs were classified according to Bjork's 9-stage system and reduced to 5- and 3-group schemes. YOLOv5 was used for automated reference point detection, and the extracted regions were classified using a multimodal deep learning framework. EfficientNet-B0 was used for 9-stage classification, and EfficientNet-B4 was used for 5- and 3-group classifications. Clinical variables (age, gender) were included, and hybrid loss strategies addressed class imbalance while preserving sequential stage relationships. Performance metrics included accuracy, recall, mAP@0.5, balanced accuracy, Cohen's Kappa coefficient, and detailed error analysis; 5-fold cross-validation and ensemble learning were used to improve robustness. RESULTS: YOLOv5 detected tooth roots in PRs (accuracy 92.5%, recall 93.3%, mAP@0.5 = 0.942) and cervical vertebrae in LCRs (accuracy 98.9%, recall 99.9%, mAP@0.5 = 0.995). In PRs, the standard accuracy in 9-, 5-, and 3-stage classifications was 0.3648, 0.5307, and 0.7520, respectively, while in LCRs, the standard accuracy in 9-, 5-, and 3-stage classifications was 0.4350, 0.6336, and 0.8975, respectively. CONCLUSION: Deep learning can reliably automate skeletal maturation assessment across imaging methods and resolutions. Appropriately optimized models provide valuable decision support in orthodontic treatment, increasing efficiency and consistency. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Orthodontic Society. FAU - Edik, Merve AU - Edik M AUID- ORCID: 0009-0002-9801-5392 AD - Department of Oral and Maxillofacial Radiology, Erciyes University Faculty of Dentistry, Kosk Mah. Ahmet El Biruni Cad. No: 52, Melikgazi, Kayseri 38030, Turkey. FAU - Celebi, Fatma AU - Celebi F AUID- ORCID: 0000-0001-7472-8297 AD - Department of Software Engineering, Faculty of Engineering, Erciyes University, Kosk Mah. Ahmet El Biruni Cad. No: 52, Melikgazi, Kayseri 38030, Turkey. FAU - Etoz, Meryem AU - Etoz M AUID- ORCID: 0000-0001-7222-0430 AD - Department of Oral and Maxillofacial Radiology, Erciyes University Faculty of Dentistry, Kosk Mah. Ahmet El Biruni Cad. No: 52, Melikgazi, Kayseri 38030, Turkey. LA - eng GR - Scientific and Technological Research Council of Turkey/ PT - Comparative Study PT - Journal Article PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 SB - IM MH - Humans MH - *Deep Learning MH - *Radiography, Panoramic/methods MH - *Cephalometry/methods MH - Female MH - Retrospective Studies MH - Male MH - *Age Determination by Skeleton/methods MH - Adolescent MH - Child MH - Convolutional Neural Networks MH - Anatomic Landmarks/diagnostic imaging MH - Detection Algorithms MH - *Hand Bones/growth & development/diagnostic imaging PMC - PMC13458939 OTO - NOTNLM OT - EfficientNet OT - deep learning OT - hand-wrist maturation OT - lateral cephalometric radiography OT - panoramic radiography COIS- Conflicts of interest: The authors declare that they have no conflicts of interest. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 PMCR- 2026/08/11 CRDT- 2026/08/11 08:23 PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 08:23 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 8758821 [pii] AID - cjag054 [pii] AID - 10.1093/ejo/cjag054 [doi] PST - ppublish SO - Eur J Orthod. 2026 Aug 6;48(5):cjag054. doi: 10.1093/ejo/cjag054. PMID- 42577908 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260811 LR - 20260813 IS - 1178-6973 (Print) IS - 1178-6973 (Electronic) IS - 1178-6973 (Linking) VI - 19 DP - 2026 TI - Miliary Tuberculosis: A Comprehensive Review of Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Complications. PG - 616761 LID - 10.2147/IDR.S616761 [doi] LID - 616761 AB - Miliary tuberculosis (TB) represents a potentially fatal form of disseminated TB resulting from the lymphohematogenous dissemination of Mycobacterium tuberculosis. Although accounting for approximately 1-2% of all TB cases in immunocompetent adults, its mortality rate exceeds 30%. This review screened peer-reviewed, original research studies via four databases (PubMed, EMBASE, MEDLINE, and CENTRAL) to synthesize up-to-date evidence. Key risk factors include human immunodeficiency virus (HIV) co-infection, anti-tumor necrosis factor-alpha (TNF-alpha) agents and chronic malnutrition. The clinical presentation of miliary TB is notoriously nonspecific, with fever, night sweats, weight loss, and constitutional symptoms predominating. Over 60% of patients have extrapulmonary complications, with central nervous system (CNS) involvement in 10-30%, abdominal involvement in 15-30%, and skeletal involvement in up to 17%. Laboratory abnormalities are common, including elevated erythrocyte sedimentation rate (ESR), anemia, lymphopenia, and nearly universal C-reactive protein (CRP) elevation. Diagnoses remain difficult due to paucibacillary lesions; novel molecular assays and a validated CNS prediction scoring system greatly improve diagnostic efficiency, while multiple microbiological and invasive tissue sampling modalities are briefly summarized for comprehensive clinical reference. Standard 6-month isoniazid, rifampicin, pyrazinamide ethambutol and isoniazid, rifampicin (HRZE-HR) regimens apply to isolated pulmonary miliary TB, whereas 9-12-month extended therapy plus adjunctive dexamethasone is required for CNS complications. Drug resistant cases demand 18-24-month individualized regimens with high blood-brain barrier penetration. Severe complications including tuberculous meningitis and high mortality acute respiratory distress syndrome (ARDS) are fully discussed, and TNF-alpha antagonists act as salvage therapy for steroid-refractory tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). Bacillus Calmette-Guerin (BCG) vaccination provides substantial protection against miliary TB in children, with efficacy of approximately 77% and favorable cost-effectiveness. Existing reviews lack integrated post-pandemic epidemiological data, cutting-edge molecular diagnostics and modern extrapulmonary treatment algorithms; this paper fills such gaps to offer balanced clinical guidance for frontline clinicians. CI - (c) 2026 Qiu et al. FAU - Qiu, Yukun AU - Qiu Y AUID- ORCID: 0009-0008-3685-2746 AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Tang, Yubin AU - Tang Y AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Yu, Shuqing AU - Yu S AD - Lanzhou Pulmonary Hospital, Lanzhou, Gansu, People's Republic of China. FAU - He, Jiaoyu AU - He J AD - Lanzhou Pulmonary Hospital, Lanzhou, Gansu, People's Republic of China. FAU - Wang, Xiaohui AU - Wang X AUID- ORCID: 0000-0002-1934-1011 AD - Clinical Laboratory, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, China. FAU - Liang, Juan AU - Liang J AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Li, Yamei AU - Li Y AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Sun, Mei AU - Sun M AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Xiao, Yongjiu AU - Xiao Y AUID- ORCID: 0000-0001-9140-3945 AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. LA - eng PT - Journal Article PT - Review DEP - 20260806 PL - New Zealand TA - Infect Drug Resist JT - Infection and drug resistance JID - 101550216 PMC - PMC13455802 OTO - NOTNLM OT - complications OT - diagnosis OT - miliary tuberculosis OT - prognosis OT - treatment COIS- The authors declare that they have no competing interests. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 PMCR- 2026/08/06 CRDT- 2026/08/11 06:38 PHST- 2026/04/14 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 06:38 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 616761 [pii] AID - 10.2147/IDR.S616761 [doi] PST - epublish SO - Infect Drug Resist. 2026 Aug 6;19:616761. doi: 10.2147/IDR.S616761. eCollection 2026. PMID- 42577566 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260811 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - Effect of an Integrated Exercise Training Program on Muscle Mass and Functional Capacity in Sarcopenic Patients With Decompensated Liver Cirrhosis. PG - e112441 LID - 10.7759/cureus.112441 [doi] LID - e112441 AB - BACKGROUND: Liver cirrhosis is an end-stage disease with extensive fibrosis that disrupts normal architecture and impairs hepatic function. Progression to decompensation triggers severe complications like ascites, jaundice, and hepatic encephalopathy. A major extrahepatic consequence is sarcopenia (muscle wasting), which affects over 65% of these patients. Driven by ammonia accumulation and chronic inflammation, this muscle loss drastically increases frailty and mortality risk. Combined aerobic and resistance exercise (CARE) represents a highly promising, underutilized rehabilitation strategy to restore their functional capacity. OBJECTIVE: The aim of this study was to assess how a structured, home-based, integrated exercise program influences muscle mass and physical functional capacity in sarcopenic patients with decompensated cirrhosis. It was hypothesized that CARE would yield measurable gains in skeletal muscle volume, exercise endurance, and liver-related biochemical parameters relative to standard care alone. METHODS: A randomized clinical trial at Krishna College of Physiotherapy, Karad, India, evaluated 40 participants aged 30-50 years with decompensated cirrhosis and a Child-Pugh score of 7-15. Simple random sampling allocated patients equally into a control group receiving standard care (n=20) or an experimental group receiving standard care plus a 12-week CARE program (n=20). The cohort comprised 24 males and 16 females, with etiologies including alcohol-associated liver disease (52.5%), hepatitis B (7.5%), and hepatitis C (5.0%). Functional capacity and muscle mass were assessed pre- and post intervention using the Six-Minute Walk Test (6MWT) and Bioelectrical Impedance Analysis (BIA), respectively. Statistical analyses utilized paired t-tests and Wilcoxon signed-rank tests, with significance set at p < 0.05. Following the 12-week intervention, the experimental group demonstrated significant pre-to-post improvements across all metrics: 6MWT distance increased from 480.1+/-3.50 to 487.55+/-5.97 meters (p < 0.0001); serum glutamic-oxaloacetic transaminase (SGOT) dropped from 66.55+/-8.54 U/L to 47.3+/-12.9 U/L (p < 0.0001); serum glutamic-pyruvic transaminase (SGPT) decreased from 68.6+/-7.67 U/L to 54.15+/-10.03 U/L (p < 0.0001); and skeletal muscle mass increased from 24.16+/-2.25 to 24.77+/-2.96 kg (p = 0.0452). Between-group comparisons at post-intervention revealed that the experimental group achieved significantly greater improvements than the control group in 6MWT distance (p = 0.0055), SGOT (p = 0.0001), and SGPT (p = 0.0001). However, the post-intervention difference in muscle mass between the experimental and control groups did not reach statistical significance (p = 0.4134). CONCLUSION: A structured, home-based CARE program produced significant improvements in functional capacity, biochemical markers, and muscle mass among sarcopenic individuals with decompensated cirrhosis. Exercise training is safe, feasible, and clinically beneficial in this population, offering a nonpharmacological strategy to mitigate sarcopenia and enhance quality of life. Incorporating rehabilitation into standard management of advanced liver disease may reduce morbidity, improve transplant outcomes, and extend survival. Future research should explore long-term adherence, optimal exercise intensity, and integration with nutritional interventions to maximize therapeutic benefit. CI - Copyright (c) 2026, Patil et al. FAU - Patil, Rushikesh S AU - Patil RS AD - Cardiopumonary Sciences, Krishna College of Physiotherapy, Krishna Vishwa Vidyapeeth, Deemed to Be University, Karad, IND. FAU - Devi, Poovishnu T AU - Devi PT AD - Cardiopulmonary Sciences, Krishna College of Physiotherapy, Krishna Vishwa Vidyapeeth, Deemed to Be University, Karad, IND. FAU - Dhaygude, Kiran S AU - Dhaygude KS AD - Cardiopulmonary Sciences, Krishna College of Physiotherapy, Krishna Vishwa Vidyapeeth, Deemed to Be University, Karad, IND. FAU - Brahmadande, Janhavee S AU - Brahmadande JS AD - Cardiopulmonary Sciences, Krishna College of Physiotherapy, Krishna Vishwa Vidyapeeth, Deemed to Be University, Karad, IND. LA - eng PT - Journal Article DEP - 20260711 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13454815 OTO - NOTNLM OT - bioelectrical impedance analysis OT - functional capacity OT - liver cirrhosis OT - muscle mass OT - sarcopenia OT - six-minute walk test COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Krishna Vishwa Vidyapeeth issued approval (289/2025-2026). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 PMCR- 2026/07/11 CRDT- 2026/08/11 06:12 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 06:12 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.7759/cureus.112441 [doi] PST - epublish SO - Cureus. 2026 Jul 11;18(7):e112441. doi: 10.7759/cureus.112441. eCollection 2026 Jul. PMID- 42577488 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260811 LR - 20260923 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - Integrated multiomics reveals stable microbe-metabolite relationships in pediatric celiac disease. PG - 1866060 LID - 10.3389/fmicb.2026.1866060 [doi] LID - 1866060 AB - Celiac disease is a lifelong immune-mediated disease triggered by dietary gluten and managed exclusively through a strict gluten-free diet. Differences in the gut microbiome are consistently observed in celiac disease, yet the associated metabolic consequences remain insufficiently defined. This study evaluated the stool microbiome-metabolome relationship in children from Canterbury, New Zealand, a region with a notably high prevalence of celiac disease ( approximately 1 in 82). Eleven children with untreated celiac disease and 10 controls were assessed, with nine children resampled after 6 months of gluten-free diet adherence. Stool samples were subjected to 16S rRNA sequencing, targeted and untargeted metabolomic profiling, and multi-omics integration using cross-block and machine-learning approaches. Celiac disease was characterized by consistent reproducible changes in a small set of resampled-stable taxa and metabolites, rather than a uniform shift. The most prominent finding was rearrangement within Bacteroides rather than a uniform shift: B. ovatus increased reproducibly in both untreated and treated disease, while integration analyses associated B. fragilis with celiac disease and B. vulgatus with controls. Metabolite changes were observed in two linked axes: a butyrate-led fermentation signature and a redox and organic acid signature, both elevated in untreated disease and shifting toward control levels after 6 months of gluten-free diet. Recovery was partial, and the diet imposed its own signature, notably an increase in the fat-responsive pathobiont Bilophila wadsworthia. Machine learning discrimination was modest (ROC-AUC = 0.66-0.68, PR-AUC = 0.73-0.79), but the microbiome and metabolome aligned along one reproducible cross-omic axis. The results support prioritizing a concise list of reproducible candidate features for mechanistic validation and longitudinal treatment monitoring in more extensive cohorts, rather than for immediate diagnostic application. CI - Copyright (c) 2026 Prendergast, Aitchison, Ho, Morris, Gobl, Dobson, Day and Ogilvie. FAU - Prendergast, Peter J AU - Prendergast PJ AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. AD - Riddet Institute, University of Canterbury, Christchurch, New Zealand. FAU - Aitchison, Alan AU - Aitchison A AD - Department of Paediatrics and Child Health, The University of Otago Christchurch, New Zealand. FAU - Ho, Shaun S C AU - Ho SSC AD - Department of Gastroenterology and Clinical Nutrition, The Royal Children's Hospital, Melbourne, Parkville, VIC, Australia. AD - Murdoch Children's Research Institute, Parkville, VIC, Australia. AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. FAU - Morris, Vanessa K AU - Morris VK AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. FAU - Gobl, Christoph AU - Gobl C AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. AD - Matai Haora - Centre for Redox Biology and Medicine, The University of Otago Christchurch, New Zealand. FAU - Dobson, Renwick C J AU - Dobson RCJ AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. AD - Riddet Institute, University of Canterbury, Christchurch, New Zealand. AD - Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia. FAU - Day, Andrew S AU - Day AS AD - Department of Paediatrics and Child Health, The University of Otago Christchurch, New Zealand. FAU - Ogilvie, Olivia J AU - Ogilvie OJ AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. AD - Riddet Institute, University of Canterbury, Christchurch, New Zealand. LA - eng PT - Journal Article DEP - 20260727 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC13454391 OTO - NOTNLM OT - Bacteroides OT - Bilophila OT - celiac disease OT - gluten-free diet OT - gut microbiome OT - metabolomics OT - multiomics OT - short-chain fatty acids COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author AD declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 PMCR- 2026/07/27 CRDT- 2026/08/11 06:06 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/20 00:00 [revised] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 06:06 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1866060 [doi] PST - epublish SO - Front Microbiol. 2026 Jul 27;17:1866060. doi: 10.3389/fmicb.2026.1866060. eCollection 2026. PMID- 42577270 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Effects of maternal exposure to an adsorbed acellular diphtheria-tetanus-pertussis (reduced-dose) combined vaccine on prenatal and postnatal development in Sprague-Dawley rats: a preclinical study. PG - 1884369 LID - 10.3389/fimmu.2026.1884369 [doi] LID - 1884369 AB - INTRODUCTION: The resurgence of pertussis poses a severe threat to infants under 3 months of age due to an inherent early-life "immunity gap." While maternal immunization with the tetanus, diphtheria, and acellular pertussis (Tdap/Tdacp) vaccine effectively mitigates this risk globally, no such vaccine is currently licensed for maternal use in China. This preclinical study aimed to systematically evaluate the reproductive and developmental toxicity, as well as the immunogenicity, of an independently developed Tdacp candidate vaccine in Sprague-Dawley (SD) rats. METHODS: Eighty-eight female SD rats were randomly assigned to four groups: negative control, adjuvant control, low-dose (0.25 ml/rat), and high-dose (0.5 ml/rat). The vaccine was administered via intramuscular injection at three time points to maximize exposure: one week prior to mating, on gestation day 6 (GD 6), and on lactation day 7 (LD 7). Systemic assessments included maternal general toxicity, reproductive performance, and embryo-fetal development. Additionally, postnatal survival, physical growth, and neuro-reflex developmental landmarks of F1 offspring were monitored. Antigen-specific antibody titers in both F0 dams and F1 offspring were quantified to evaluate immunogenicity and maternal antibodies transfer. RESULTS: Repeated maternal exposure to the Tdacp vaccine elicited no treatment-related maternal systemic toxicity; body weight, food consumption, and gestation length remained comparable to controls. No adverse effects were observed on mating, fertility, or uterine implantation. Furthermore, the vaccine did not negatively impact F1 offspring survival, sex ratio, physical morphology, or the acquisition of neuro-reflex milestones. Immunologically, the vaccine induced robust and stable antibody responses against all specific antigens, including pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN), diphtheria toxoid (DT), and tetanus toxoid (TT), in F0 dams. Crucially, high titers of these antigen-specific antibodies were detected in the F1 offspring, demonstrating successful passive transfer of maternal antibodies to the offspring. CONCLUSION: The investigational Tdacp vaccine demonstrated a highly favorable safety profile with no evidence of maternal, reproductive, or developmental toxicity. Coupled with its robust immunogenicity and efficient maternal antibody transfer, these findings provide pivotal preclinical validation to support advancing the vaccine into human clinical trials for maternal immunization. CI - Copyright (c) 2026 Kong, Chu, Gu, Ma, Cai, Li, Wang, Ji, Wen, Gao, Ji, Hu, Zhao, Ping, Fu, Li, Gong, Jin, Yang, Fu, Qin, Zheng, Yang and Liang. FAU - Kong, Wenlu AU - Kong W AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. FAU - Chu, Han AU - Chu H AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. FAU - Gu, Qin AU - Gu Q AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Ma, Yan AU - Ma Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Cai, Lukui AU - Cai L AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Li, Jingyan AU - Li J AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Wang, Xiaoyu AU - Wang X AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Ji, Qiuyan AU - Ji Q AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Wen, Jiana AU - Wen J AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Gao, Na AU - Gao N AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Ji, Guang AU - Ji G AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Hu, Wenzhu AU - Hu W AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Zhao, Ting AU - Zhao T AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Ping, Ling AU - Ping L AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Fu, Yuting AU - Fu Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Li, Ying AU - Li Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. FAU - Gong, Tiannan AU - Gong T AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. FAU - Jin, Yingfu AU - Jin Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. FAU - Yang, Yufan AU - Yang Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. FAU - Fu, Yixian AU - Fu Y AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. FAU - Qin, Xinhua AU - Qin X AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. FAU - Zheng, Huimei AU - Zheng H AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. FAU - Yang, Jingsi AU - Yang J AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. FAU - Liang, Jiangli AU - Liang J AD - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. AD - State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. AD - Kunming Scientific and Technological Innovation Center for R&D and Industrialization of Vaccines Against Novel and Emerging Highly Pathogenic Pathogens, Kunming, China. LA - eng PT - Journal Article DEP - 20260727 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Diphtheria-Tetanus-acellular Pertussis Vaccines) RN - 0 (Antibodies, Bacterial) RN - 0 (Vaccines, Combined) SB - IM MH - Animals MH - Female MH - Rats, Sprague-Dawley MH - Rats MH - Pregnancy MH - *Maternal Exposure/adverse effects MH - *Diphtheria-Tetanus-acellular Pertussis Vaccines/immunology/administration & dosage/adverse effects MH - Antibodies, Bacterial/blood/immunology MH - *Prenatal Exposure Delayed Effects MH - Vaccines, Combined/immunology/administration & dosage MH - *Whooping Cough/prevention & control/immunology PMC - PMC13453739 OTO - NOTNLM OT - Tdacp vaccine OT - maternal antibody transfer OT - maternal immunization OT - reproductive and developmental toxicity OT - safety evaluation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/11 06:35 MHDA- 2026/08/11 12:37 PMCR- 2026/07/27 CRDT- 2026/08/11 05:42 PHST- 2026/05/18 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/08/11 12:37 [medline] PHST- 2026/08/11 06:35 [pubmed] PHST- 2026/08/11 05:42 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1884369 [doi] PST - epublish SO - Front Immunol. 2026 Jul 27;17:1884369. doi: 10.3389/fimmu.2026.1884369. eCollection 2026. PMID- 42577167 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Latent profiles of problematic internet use and their associations with physical activity levels among college students: a cross-sectional study. PG - 1818418 LID - 10.3389/fpubh.2026.1818418 [doi] LID - 1818418 AB - OBJECTIVE: To identify latent profiles of problematic internet use (PIU) among college students and examine their associations with physical activity (PA) levels. METHODS: A stratified cluster sampling survey was conducted among 2,660 college students from central China. Problematic short video, social media, and internet game use were assessed using validated scales, and PA level was measured using the Physical Activity Rating Scale-3. Latent profile analysis was performed to identify PIU profiles. Multinomial logistic regression was used to examine the associations between PA levels and profile membership after adjusting for sociodemographic characteristics. RESULTS: Four heterogeneous latent profiles of problematic internet use were identified among college students: the Low-risk problematic use profile (n = 1,630, 61.28%), the Social media-dominant problematic use profile (n = 304, 11.43%), the Gaming-dominant problematic use profile (n = 478, 17.97%), and the High-risk problematic use profile (n = 248, 9.32%). Multinomial logistic regression analyses showed that, compared with the Low-risk profile, male students had higher odds of membership in the Gaming-dominant profile (OR = 2.122, 95%CI:1.697-2.654) and the High-risk profile (OR = 1.714, 95%CI:1.292-2.273), but lower odds of membership in the Social media-dominant profile (OR = 0.767, 95%CI:0.598-0.983). Sophomore and junior students had significantly higher odds of membership in all three non-low-risk profiles, whereas senior students had significantly lower odds. Off-campus residence was associated with lower odds of membership in the Gaming-dominant profile (OR = 0.508, 95%CI:0.298-0.864). High-level physical activity was associated with lower odds of membership in the Social media-dominant (OR = 0.585, 95%CI:0.395-0.866), Gaming-dominant (OR = 0.371, 95%CI:0.255-0.539), and High-risk profiles (OR = 0.552, 95%CI:0.353-0.862). Moderate-level physical activity was associated with lower odds of membership only in the Gaming-dominant profile (OR = 0.795, 95%CI:0.632-0.999). CONCLUSION: PIU among college students exhibits substantial heterogeneity. The observed associations between PA levels and profile membership may inform targeted PIU prevention strategies. CI - Copyright (c) 2026 Peng, Zhou and Chen. FAU - Peng, Wenzhi AU - Peng W AD - Department of Physical Education Teaching and Research, Central South University, Changsha, Hunan, China. FAU - Zhou, Zeng AU - Zhou Z AD - Department of Physical Education Teaching and Research, Central South University, Changsha, Hunan, China. AD - College of Sports Science, Jishou University, Jishou, Hunan, China. FAU - Chen, Ziyi AU - Chen Z AD - College of Physical Education and Health, Guangxi Normal University, Guilin, Guangxi, China. LA - eng PT - Journal Article DEP - 20260727 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - *Students/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - *Exercise MH - Female MH - Young Adult MH - China/epidemiology MH - Universities MH - *Internet Addiction Disorder/epidemiology MH - *Internet Use/statistics & numerical data MH - Surveys and Questionnaires MH - Adolescent MH - *Behavior, Addictive/epidemiology MH - Digital Media MH - Video Games/statistics & numerical data PMC - PMC13453751 OTO - NOTNLM OT - behavioral addiction OT - college students OT - latent profiles OT - physical activity levels OT - problematic internet use COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/11 06:35 MHDA- 2026/08/11 12:37 PMCR- 2026/07/27 CRDT- 2026/08/11 05:32 PHST- 2026/02/26 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/11 12:37 [medline] PHST- 2026/08/11 06:35 [pubmed] PHST- 2026/08/11 05:32 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1818418 [doi] PST - epublish SO - Front Public Health. 2026 Jul 27;14:1818418. doi: 10.3389/fpubh.2026.1818418. eCollection 2026. PMID- 42576304 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260831 IS - 1541-4337 (Electronic) IS - 1541-4337 (Linking) VI - 25 IP - 5 DP - 2026 Sep TI - Front-of-Package Nutrition Labeling for Foods and Beverages Marketed to Children: Behavioral, Nutritional, and Cognitive-Affective Outcomes and Methodological Quality-A Systematic Review. PG - e70604 LID - 10.1111/1541-4337.70604 [doi] LID - e70604 AB - Front-of-package labeling (FOPL) is increasingly used to support healthier food choices, but its role in early childhood, where decisions are largely caregiver-mediated, remains uncertain. This systematic review assessed the methodological quality and certainty of evidence on FOPL for foods and beverages marketed to children and synthesized behavioral, nutritional, and cognitive-affective outcomes among children and caregivers. Following PRISMA 2020, five bibliographic databases and BASE were searched through July 2025. Risk of bias was assessed using JBI tools, and certainty was evaluated using GRADE and GRADE-CERQual. Thirty-nine studies were included: 18 RCTs, five quasi-experimental studies, six cross-sectional studies, and 10 qualitative studies. Evidence most consistently supported effects on perceived healthfulness, purchase intention, and, in some comparisons, product selection and purchase. Warning labels showed the clearest directional pattern, particularly for discouraging selection or intended purchase of less healthy products, but evidence varied by outcome and comparator. Nutritional outcomes were more heterogeneous and generally of low or very low certainty. Educational components tended to favor FOPL conditions in direction-of-effect summaries, but the evidence was of very low certainty and insufficient to establish a reliable incremental benefit. Qualitative findings indicated that FOPL can function as a simple heuristic for caregivers, although use is shaped by comprehension, trust, context, and everyday constraints. Overall, FOPL may support early stages of caregiver-mediated decision-making, but sustained nutritional impact remains uncertain. The absence of a universally superior format argues against one-size-fits-all labeling; policies should prioritize interpretive clarity and contextual fit and support longitudinal, real-world evaluations. CI - (c) 2026 Institute of Food Technologists(R). FAU - Soares, Filipa AU - Soares F AD - LAQV-REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, Laboratory of Bromatology and Hydrology, University of Porto, Porto, Portugal. FAU - Cruz, Rebeca AU - Cruz R AUID- ORCID: 0000-0001-9685-231X AD - LAQV-REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, Laboratory of Bromatology and Hydrology, University of Porto, Porto, Portugal. LA - eng GR - IJUP Empresas and SONAE MC/ GR - Inovacao Nutricional e Sustentavel para Alimentacao Infantil/ GR - FODMAPS-Food Optimization for Dietary Management and Advanced Product Solutions/ PT - Journal Article PT - Systematic Review PL - United States TA - Compr Rev Food Sci Food Saf JT - Comprehensive reviews in food science and food safety JID - 101305205 SB - IM MH - *Food Labeling/methods MH - Humans MH - *Beverages MH - Child MH - Cognition MH - Nutritive Value MH - Choice Behavior MH - Food Preferences PMC - PMC13457996 OTO - NOTNLM OT - child nutrition OT - choice behavior OT - food policy OT - food preferences OT - front-of-package labeling OT - nutritional labeling COIS- The authors declare no conflicts of interest. EDAT- 2026/08/11 06:35 MHDA- 2026/08/11 06:36 PMCR- 2026/08/11 CRDT- 2026/08/11 00:53 PHST- 2026/07/09 00:00 [revised] PHST- 2026/02/05 00:00 [received] PHST- 2026/07/24 00:00 [accepted] PHST- 2026/08/11 06:36 [medline] PHST- 2026/08/11 06:35 [pubmed] PHST- 2026/08/11 00:53 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - CRF370604 [pii] AID - 10.1111/1541-4337.70604 [doi] PST - ppublish SO - Compr Rev Food Sci Food Saf. 2026 Sep;25(5):e70604. doi: 10.1111/1541-4337.70604. PMID- 42576292 OWN - NLM STAT- Publisher LR - 20260811 IS - 1601-5037 (Electronic) IS - 1601-5029 (Linking) DP - 2026 Aug 10 TI - Impact of an Educational Video Intervention on Word Recognition and Vocabulary Knowledge of Paediatric Dental Terms Among Low-Income Caregivers of Young Children. LID - 10.1111/idh.70147 [doi] AB - OBJECTIVE: To evaluate the impact of an educational intervention on paediatric dental term recognition and vocabulary knowledge among low-income caregivers of young children. METHODS: A randomized two-group pretest-posttest trial was used to analyze the impact of an educational intervention on caregivers' word recognition and vocabulary knowledge of paediatric dental terms. The study included 60 pregnant women and caregivers with children enrolled in a Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in the Southeastern United States. Both groups received an educational pamphlet on children's oral health. The experimental group also received an educational video with common paediatric dental terms (e.g., fluoride, decay). The validated Oral Health Literacy Inventory for Parents (OH-LIP) measured word recognition and vocabulary knowledge for 36 paediatric dental terms. Scoring of the inventory was completed by two researchers. RESULTS: Baseline OH-LIP scores for Part I (word recognition) were high in both groups, with a median (IQR) of 95.83 (11.11). In contrast, baseline OH-LIP scores for Part II (vocabulary knowledge) were low to moderate, with a mean (SD) of 39.24 (14.06). In regression analysis, there was no evidence that the intervention significantly improved knowledge scores before (p = 0.62) or after (p = 0.33) adjusting for baseline characteristics. Baseline vocabulary knowledge scores were the strongest predictor of post-intervention scores (p < 0.001). CONCLUSIONS: OH-LIP Part I and II scores changed modestly, but there was no statistically significant difference between groups post-intervention among low-income pregnant women and caregivers. These findings highlight the need for developing and testing different modalities, such as one-to-one education or in-person group education, to improve OHL. CI - (c) 2026 The Author(s). International Journal of Dental Hygiene published by John Wiley & Sons Ltd. FAU - Sullivan, Melissa L AU - Sullivan ML AUID- ORCID: 0009-0006-0176-4856 AD - Gene W. Hirschfeld School of Dental Hygiene, Ellmer College of Health Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA. FAU - McKinney, Denise C AU - McKinney DC AD - Gene W. Hirschfeld School of Dental Hygiene, Ellmer College of Health Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA. FAU - Al-Taiar, Abdullah AU - Al-Taiar A AUID- ORCID: 0000-0001-7421-3381 AD - Joint School of Public Health, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA. FAU - Shuman, Deanne AU - Shuman D AD - Gene W. Hirschfeld School of Dental Hygiene, Ellmer College of Health Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA. LA - eng PT - Journal Article DEP - 20260810 PL - England TA - Int J Dent Hyg JT - International journal of dental hygiene JID - 101168070 SB - IM OTO - NOTNLM OT - Women, Infants, and Children (WIC) OT - caregivers OT - early childhood caries (ECC) OT - health services research OT - intervention OT - oral health literacy (OHL) OT - public health EDAT- 2026/08/11 06:35 MHDA- 2026/08/11 06:35 CRDT- 2026/08/11 00:43 PHST- 2026/06/04 00:00 [revised] PHST- 2025/10/10 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/11 06:35 [medline] PHST- 2026/08/11 06:35 [pubmed] PHST- 2026/08/11 00:43 [entrez] AID - 10.1111/idh.70147 [doi] PST - aheadofprint SO - Int J Dent Hyg. 2026 Aug 10. doi: 10.1111/idh.70147. PMID- 42575069 OWN - NLM STAT- MEDLINE DCOM- 20260829 LR - 20260829 IS - 1873-3379 (Electronic) IS - 0891-4222 (Linking) VI - 176 DP - 2026 Sep TI - The longitudinal relationship between physical activity and social skills in children with autism: Basic psychological need satisfaction in exercise as a potential pathway. PG - 105362 LID - S0891-4222(26)00157-5 [pii] LID - 10.1016/j.ridd.2026.105362 [doi] AB - OBJECTIVE: To examine the longitudinal association between physical activity and social skills in children with autism and evaluate basic psychological need satisfaction in exercise as a potential longitudinal indirect pathway. METHODS: A three-wave longitudinal study was conducted in seven special education schools in Sichuan, Hunan, and Yunnan, China. Data were collected in November 2025, February 2026, and May 2026 at three-month intervals. Primary caregivers completed all questionnaires. After excluding attrition cases and invalid responses, 584 valid cases were retained. Physical activity, basic psychological need satisfaction in exercise, and social skills were assessed using validated Chinese scales. Measurement invariance testing and fixed-effect cross-lagged panel modeling were supplemented by a longitudinal latent-variable model, demographic- and physical-activity-scaling sensitivity analyses, and random-effects cross-lagged panel modeling. RESULTS: The preliminary bivariate CLPM showed inadequate global fit; therefore, its path coefficients were not used for substantive inference. In the primary three-variable longitudinal model, physical activity showed consistent positive prospective associations with social skills across both adjacent intervals (beta = 0.274 and 0.169, respectively; both p < 0.001). T1 physical activity was positively associated with T2 basic psychological need satisfaction in exercise (beta = 0.105, p = 0.002), which was subsequently associated with higher T3 social skills (beta = 0.188, p < 0.001). This pathway yielded a small positive standardized indirect effect (effect = 0.020, 95% CI [0.007, 0.039], p = 0.015). The directly estimated association between T1 physical activity and T3 social skills also remained positive (effect = 0.137, 95% CI [0.068, 0.213], p < 0.001), indicating that basic psychological need satisfaction in exercise accounted for part, but not all, of the longitudinal association. The focal indirect effect was replicated in the longitudinal latent-variable, covariate-adjusted, and alternative physical-activity-scoring analyses, with estimates ranging from 0.022 to 0.029. The targeted random-effects model yielded a comparable point estimate (0.022), although with greater uncertainty (95% CI [-0.012, 0.056]). CONCLUSION: These findings position physical activity as a recurring developmental context associated with later social-skill development in children with autism and indicate that basic psychological need satisfaction in exercise may modestly help explain this longitudinal relationship. They further suggest that the social-developmental relevance of physical activity may depend partly on whether participation supports autonomy, competence, and relatedness, underscoring the importance of considering the psychological quality of participation alongside activity volume. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Chen, Longjiang AU - Chen L AD - School of Physical Education, Yunnan Normal University, Kunming, China. Electronic address: longjiang-chen@outlook.com. FAU - Mei, Zhengyang AU - Mei Z AD - School of Physical Education, Central China Normal University, Wuhan, China. Electronic address: meizhengyang0823@126.com. FAU - Cai, Chenyi AU - Cai C AD - School of Physical Education, Southwest University, Chongqing, China. Electronic address: caichenyi2002@126.com. FAU - Yin, Tian AU - Yin T AD - School of Physical Education, Yunnan Minzu University, Kunming, China. Electronic address: shanliangdenanzihan@ymu.edu.cn. FAU - Xiang, Yian AU - Xiang Y AD - Department of Rehabilitation Medicine, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China. Electronic address: xyian@126.com. LA - eng PT - Journal Article DEP - 20260810 PL - United States TA - Res Dev Disabil JT - Research in developmental disabilities JID - 8709782 SB - IM MH - Humans MH - Male MH - Longitudinal Studies MH - Female MH - Child MH - *Exercise/psychology MH - *Social Skills MH - *Personal Satisfaction MH - *Autistic Disorder/psychology MH - China MH - Education, Special MH - *Autism Spectrum Disorder/psychology MH - Surveys and Questionnaires OTO - NOTNLM OT - Basic psychological need satisfaction in exercise OT - Children with autism OT - Longitudinal study OT - Physical activity OT - Social skills COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 00:35 MHDA- 2026/08/29 23:35 CRDT- 2026/08/10 18:10 PHST- 2026/06/20 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/29 23:35 [medline] PHST- 2026/08/11 00:35 [pubmed] PHST- 2026/08/10 18:10 [entrez] AID - S0891-4222(26)00157-5 [pii] AID - 10.1016/j.ridd.2026.105362 [doi] PST - ppublish SO - Res Dev Disabil. 2026 Sep;176:105362. doi: 10.1016/j.ridd.2026.105362. Epub 2026 Aug 10. PMID- 42574849 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 269 DP - 2026 Sep TI - Drivers of sustainable sport behavior in university students: Model development and validation. PG - 107572 LID - S0001-6918(26)01373-9 [pii] LID - 10.1016/j.actpsy.2026.107572 [doi] AB - This study developed and evaluated an integrative model of sustainable sport behavior among university students, defined as a theoretically linked but noninterchangeable pair of outcomes: maintenance of sport and physical activity participation and eco-aligned sport choices. Drawing on the Theory of Planned Behavior (TPB), self-regulation, motivation, social influence, and ecological perspectives, the study examined the confirmatory contribution of core TPB constructs and the incremental contribution of selected psychological, social, environmental, and sustainability-related factors. A two-phase design was used. In Phase 1, newly developed items measuring eco-aligned sport choices, visible sustainability practices, and perceived gendered/cultural barriers were reviewed by experts, refined through cognitive interviews, and examined using exploratory factor analysis with 284 students. In Phase 2, confirmatory factor analysis, measurement invariance testing, and structural equation modeling were conducted with 948 undergraduate students; 412 students provided behavior data at an eight-week follow-up. The measurement analyses supported two related first-order dimensions; a second-order score was retained for concise reporting, although the correlated two-factor solution showed a small fit advantage. Perceived behavioral control showed the largest association with intention, and T1 intention was prospectively associated with T2 behavior after baseline behavior was considered. Self-efficacy, perceived competence, intrinsic motivation, peer support, scheduling compatibility, access, physical environment quality, and visible sustainability practices showed additional, generally small associations. Statistical indirect associations through stress and anxiety were interpreted cautiously. Measurement invariance was evaluated for women and men and across academic stage. The findings indicate that sustainable sport behavior is associated with both individual regulation and inclusive, accessible, schedule-sensitive, and visibly sustainable campus conditions; however, the 43.5% follow-up retention, self-report measurement, and the observational nature of most paths limit causal inference. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Chen, Xiao AU - Chen X AD - Faculty of Sports Science and Technology, Bangkok Thonburi University, Bangkok, Thailand. Electronic address: chenxiao2152@outlook.com. FAU - Esmaeili, Ali AU - Esmaeili A AD - Allameh Tabataba'i University, Tehran, Iran. Electronic address: ali.esmaeili@atu.ac.ir. LA - eng PT - Journal Article PT - Validation Study DEP - 20260810 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - *Students/psychology MH - Female MH - Universities MH - Theory of Planned Behavior MH - *Sports/psychology MH - *Motivation MH - Male MH - Young Adult MH - Self Efficacy MH - Adult MH - Intention MH - Self-Control MH - *Models, Psychological MH - Adolescent MH - *Exercise/psychology OTO - NOTNLM OT - Campus sustainability OT - Motivation OT - Perceived behavioral control OT - Physical activity OT - Structural equation modeling OT - Sustainable sport behavior OT - University students COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/08/11 00:35 MHDA- 2026/08/25 05:34 CRDT- 2026/08/10 18:02 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/08/11 00:35 [pubmed] PHST- 2026/08/10 18:02 [entrez] AID - S0001-6918(26)01373-9 [pii] AID - 10.1016/j.actpsy.2026.107572 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Sep;269:107572. doi: 10.1016/j.actpsy.2026.107572. Epub 2026 Aug 10. PMID- 42574428 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Moving Kindergartens: Protocol for a 10-week feasibility study. PG - e0354826 LID - 10.1371/journal.pone.0354826 [doi] LID - e0354826 AB - OBJECTIVE: The primary aim of this study is to evaluate the feasibility of a proposed intervention designed to support the daily movement practices and fostering joy of movement in Danish kindergartens, as well as the implementation strategies intended to facilitate adoption. Additionally, the feasibility of the planned measurement and procedures for a future effectiveness study will be examined. METHODS: The study uses a mixed-methods design to examine the feasibility of the intervention and the evaluation design. The planned duration of the intervention period is 10 weeks. The intervention consists of multiple integrated components co-designed with pedagogical staff, leaders, experts in kindergarten movement culture, and a team of researchers, to collectively support the daily movement practice in kindergartens. Alongside the intervention components, tailored strategies are developed to facilitate adoption and implementation. The intervention elements are categorized into four main types: 1) Formal establishment of the project; 2) Components of physical activity integrated in existing structures in the kindergarten; 3) Organizational and staff training; 4) Inspirational materials, tools and exemplary plans. DISCUSSION: The use of a co-design approach in close collaboration between kindergartens, experts, and a team of researchers will ensure contextual relevance and shared ownership. This approach is expected to enhance acceptability, feasibility, and sustainability of the intervention. The mixed-methods evaluation design, use of theoretical implementation frameworks, and tailored strategies further strengthen the study. The findings from this feasibility study will inform the refinement of the final intervention and guide the planning of a forthcoming effectiveness study. CI - Copyright: (c) 2026 Bandak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Bandak, Elisabeth AU - Bandak E AD - Department of Midwifery, Physiotherapy, Occupational Therapy and Psychomotor Therapy, University College Copenhagen, Copenhagen, Denmark. AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. FAU - Jeppesen, Lise Sohl AU - Jeppesen LS AD - Department of Midwifery, Physiotherapy, Occupational Therapy and Psychomotor Therapy, University College Copenhagen, Copenhagen, Denmark. AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. FAU - Sederberg, Mathilde AU - Sederberg M AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. FAU - Pawlowski, Charlotte Skau AU - Pawlowski CS AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. AD - Active Living Research Unit, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Bugge, Anna AU - Bugge A AUID- ORCID: 0000-0002-8345-1434 AD - Department of Midwifery, Physiotherapy, Occupational Therapy and Psychomotor Therapy, University College Copenhagen, Copenhagen, Denmark. AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. LA - eng PT - Journal Article DEP - 20260810 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Feasibility Studies MH - *Schools MH - Child, Preschool MH - Denmark MH - *Exercise MH - Research Design PMC - PMC13456249 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/10 18:36 MHDA- 2026/08/10 18:37 PMCR- 2026/08/10 CRDT- 2026/08/10 13:34 PHST- 2025/12/12 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/10 18:37 [medline] PHST- 2026/08/10 18:36 [pubmed] PHST- 2026/08/10 13:34 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - PONE-D-25-65081 [pii] AID - 10.1371/journal.pone.0354826 [doi] PST - epublish SO - PLoS One. 2026 Aug 10;21(8):e0354826. doi: 10.1371/journal.pone.0354826. eCollection 2026. PMID- 42573939 OWN - NLM STAT- Publisher LR - 20260810 IS - 0974-7559 (Electronic) IS - 0019-6061 (Linking) DP - 2026 Aug 10 TI - A Multicenter Study for Validation of the New Pediatric Advanced Life Support Tape for Indian Children. LID - 10.1007/s13312-026-00419-z [doi] AB - OBJECTIVE: Accurate weight estimation is essential for drug dosing and equipment selection in pediatric emergencies. A new Pediatric Advanced Life Support (ALS) tape was developed using Indian growth references. The present study was performed to validate its performance in critically ill children across multiple centers in India. METHODS: A prospective, cross-sectional, multicenter observational study was conducted in 13 pediatric intensive care units (PICUs) across five zones of India in children aged < 12 years. Recumbent length was measured using the new ALS tape, and color-band-based estimated weight recorded. Weight was measured using a digital scale. The primary outcomes were bias, precision, and accuracy of the tape in predicting weight. Secondary outcomes included correlation between estimated and measured weight, agreement using Bland-Altman analysis, center-wise subgroup analyses, and interrater reliability for color-band assignment. RESULTS: Out of 2740 children measured, 2253 were included in the final analysis. Correct color-band concordance was observed in 79.9% of children. Overall, 78.6% of estimates were within +/- 10% and 84.6% within +/- 15% of measured weight. The mean difference between estimated and measured weight was - 0.6 kg (0.08%). Lower color bands showed modest underestimation (13.1%), while higher bands showed mild overestimation (- 10.3%). Regional concordance ranged from 65.9% to 91.4%. Interrater reliability demonstrated strong agreement (kappa = 0.84; 95% CI 0.61, 1.00). CONCLUSIONS: The Indianized Pediatric ALS tape demonstrated acceptable accuracy, minimal overall bias, and strong interrater reliability in critically ill Indian children. Although some variability was observed across regions and lower weight bands, the new ALS tape represents a practical and reasonably accurate indigenous alternative for emergency weight estimation in diverse PICU settings across India. CI - (c) 2026. The Author(s). FAU - Khadilkar, Vaman AU - Khadilkar V AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India. FAU - Mondkar, Shruti AU - Mondkar S AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India. FAU - Baalaaji, A R Mullai AU - Baalaaji ARM AD - KMCH Institute of Health Sciences and Research, Coimbatore, India. FAU - Bhutada, Anand AU - Bhutada A AD - New Era Mother and Child Hospital, Nagpur, India. FAU - Dhongade, Ashish AU - Dhongade A AD - Shaishav Children's Hospital and Research Center, Pune, India. FAU - Lad, Sagar S AU - Lad SS AD - Jehangir Hospital, Pune, India. FAU - Lad, Preeti AU - Lad P AD - Sahyadri Manipal Superspeciality Hospital, Pune, India. FAU - Jain, Mukesh Kumar AU - Jain MK AD - Kalinga Institute of Medical Science, KIIT University, Bhubaneshwar, India. FAU - Patnaik, Sibabratta AU - Patnaik S AD - Kalinga Institute of Medical Science, KIIT University, Bhubaneshwar, India. FAU - Sarkar, Mihir AU - Sarkar M AD - Medical College Kolkata, Kolkata, India. FAU - Shaikh, Farhan AU - Shaikh F AD - Rainbow Children's Hospital, Hyderabad, India. FAU - Sharma, Manish AU - Sharma M AD - SMS Medical College, Jaipur, India. FAU - Shetty, Rakshay AU - Shetty R AD - Rainbow Children's Hospital, Bengaluru, India. FAU - Upadhyay, Nitesh AU - Upadhyay N AD - Gandhi Medical College, Bhopal, India. FAU - Vohra, Rohit AU - Vohra R AD - Indraprastha Apollo Hospital, New Delhi, India. FAU - Wagle-Patki, Sonali AU - Wagle-Patki S AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India. FAU - Khadilkar, Anuradha AU - Khadilkar A AUID- ORCID: 0000-0002-3399-3235 AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India. anuradhavkhadilkar@gmail.com. FAU - Patki, Vinayak AU - Patki V AD - KIMS-Ushahkal Abhinav Institute of Medical Sciences, Sangli, India. FAU - James, Ebor Jacob G AU - James EJG AD - Christian Medical College, Vellore, India. FAU - Shah, Sachin AU - Shah S AD - Surya Mother and Child Superspeciality Hospital, Pune, Maharashtra, India. FAU - Bansal, Arun AU - Bansal A AD - Pediatric Critical Care Division, Department of Pediatrics, PGIMER, Chandigarh, India. LA - eng PT - Journal Article DEP - 20260810 PL - India TA - Indian Pediatr JT - Indian pediatrics JID - 2985062R SB - IM OTO - NOTNLM OT - ALS tape OT - PICU OT - Pediatric emergency OT - Validation study OT - Weight estimation COIS- Ethics Approval: Approval was obtained from the Institutional Ethics Committees of all collaborating centers. Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India was the coordinating center for this study. Conflict of Interest: None. Use of Artificial Intelligence (AI) Tools for Scientific Writing: None. EDAT- 2026/08/10 12:36 MHDA- 2026/08/10 12:36 CRDT- 2026/08/10 11:22 PHST- 2026/04/20 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/10 12:36 [medline] PHST- 2026/08/10 12:36 [pubmed] PHST- 2026/08/10 11:22 [entrez] AID - 10.1007/s13312-026-00419-z [pii] AID - 10.1007/s13312-026-00419-z [doi] PST - aheadofprint SO - Indian Pediatr. 2026 Aug 10. doi: 10.1007/s13312-026-00419-z. PMID- 42573896 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260810 LR - 20260813 IS - 2948-2801 (Electronic) IS - 2948-2801 (Linking) VI - 4 IP - 3 DP - 2026 Aug 10 TI - A safety-aware intake modeling framework for translating edible algal biomass into nutritional bioproducts. LID - 10.1007/s44307-026-00129-4 [doi] LID - 32 AB - Edible algal biomass has emerged as a promising platform for nutritional bioproduct development, but its practical translation depends on compositional variability, intake feasibility, and safety constraints. Here, we integrated biochemical profiling, trace element screening, age-specific intake modeling, and community consumption context to evaluate commercially available and supplier-provided microalgal and seaweed products within realistic application boundaries. Selected products differed substantially in macronutrient composition, fatty acid profiles, pigments, polyphenols, and mineral composition, indicating product- and species-specific roles as nutritional biomass rather than interchangeable ingredients. Across species and age groups, approximately 0.7 to 3.1 g dry biomass provided 20% of age-specific alpha-linolenic acid intake, with approximately 1 g sufficient for several products. Multi-species allocations improved omega-3 representation while remaining within practical intake limits and trace element-based screening thresholds. Community consumption data from Pacific Island children showed low and episodic seaweed intake, highlighting a gap between biomass potential and routine dietary use. These findings support safety-aware modeling as a preliminary screening and decision-support strategy for evaluating edible algal biomass before further product-specific validation. CI - (c) 2026. The Author(s). FAU - Wang, Yu AU - Wang Y AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Roell, Garrett AU - Roell G AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Cruz, Rica Dela AU - Cruz RD AD - Department of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Durdakova, Michaela AU - Durdakova M AD - Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300, Brno, Czech Republic. AD - Research Center for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty Kopec 7, 65653, Brno, Czech Republic. FAU - Maruwan, Jessica AU - Maruwan J AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Rong, Kexin AU - Rong K AD - Water Resources Research Center, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Novotny, Rachel AU - Novotny R AD - Department of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Esquivel, Monica AU - Esquivel M AD - Department of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Wilkens, Lynne AU - Wilkens L AD - University of Hawai'i Cancer Center, Honolulu, Hawai'i, 96822, USA. FAU - Su, Wei Wen AU - Su WW AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Yan, Tao AU - Yan T AD - Water Resources Research Center, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Ho, Kacie AU - Ho K AD - Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300, Brno, Czech Republic. FAU - Du, Zhi-Yan AU - Du ZY AUID- ORCID: 0000-0001-7646-2429 AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. duz@hawaii.edu. LA - eng GR - 23-FY23-HA-5047H-DU/University of Hawai'i at Manoa/ GR - 2022-38500-38099/National Institute of Food and Agriculture/ GR - 2021-333/Institute of Clinical and Translational Sciences/ PT - Journal Article DEP - 20260810 PL - Singapore TA - Adv Biotechnol (Singap) JT - Advanced biotechnology JID - 9918821788106676 PMC - PMC13457825 OTO - NOTNLM OT - Algal biotechnology OT - Edible algal biomass OT - Microalgae OT - Nutritional bioproducts OT - Omega-3 fatty acids OT - Safety-aware modeling COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: The work described has not been published before and is not under consideration for publication elsewhere. All co-authors have approved the final version. Competing interests: Author Z.-Y.D. is member of the Editorial Board for Advanced Biotechnology, and the author is not involved in the journal's review and decisions related to this manuscript. EDAT- 2026/08/10 12:36 MHDA- 2026/08/10 12:37 PMCR- 2026/08/10 CRDT- 2026/08/10 11:21 PHST- 2026/05/20 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/07/26 00:00 [revised] PHST- 2026/08/10 12:37 [medline] PHST- 2026/08/10 12:36 [pubmed] PHST- 2026/08/10 11:21 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.1007/s44307-026-00129-4 [pii] AID - 129 [pii] AID - 10.1007/s44307-026-00129-4 [doi] PST - epublish SO - Adv Biotechnol (Singap). 2026 Aug 10;4(3):32. doi: 10.1007/s44307-026-00129-4. PMID- 42572679 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260810 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - Comparison of YouTube Videos and Artificial Intelligence Chatbot Responses Regarding Pediatric Pelvic Floor Dysfunction: A Cross-Sectional Infodemiology Study. PG - e112387 LID - 10.7759/cureus.112387 [doi] LID - e112387 AB - BACKGROUND: Pediatric pelvic floor dysfunction is a common cause of lower urinary tract symptoms and bowel dysfunction in children, requiring accurate and reliable educational resources for patients and caregivers. With the increasing use of online health information, both YouTube (Google LLC, Mountain View, CA, USA) and artificial intelligence (AI) chatbots have become frequently used sources of medical guidance. This study aimed to evaluate and compare the educational quality, reliability, and safety of YouTube videos and AI-generated responses related to pediatric pelvic floor dysfunction. MATERIALS AND METHODS: In this cross-sectional infodemiology study, YouTube was searched using five predefined pediatric pelvic floor-related search terms, and the first 50 videos for each term were screened. After duplicate removal and eligibility assessment, 25 videos were included for analysis. Three publicly available AI chatbots (ChatGPT (OpenAI, San Francisco, CA, USA), Gemini (Google LLC, Mountain View, CA, USA), and Copilot (Microsoft Corporation, Redmond, WA, USA)) were evaluated using a standardized set of 20 pediatric pelvic floor-related questions. Educational quality was independently assessed using the DISCERN instrument, the Global Quality Scale (GQS), and the Pediatric Pelvic Floor Education and Reliability Score (PPFERS), a pediatric-specific assessment tool developed for this study. RESULTS: The 25 included YouTube videos accumulated 447,398 total views. Physiotherapists or pediatric physical therapists were the most common content creators (44.0%), followed by healthcare institutions (28.0%). The mean DISCERN, GQS, and PPFERS scores for YouTube videos were 66.24 +/- 8.64, 4.28 +/- 0.74, and 16.88 +/- 1.96, respectively. Among AI chatbots, Gemini achieved the highest educational quality scores (76.00 +/- 1.92, 4.95 +/- 0.22, and 19.35 +/- 0.59), followed by ChatGPT (74.20 +/- 2.40, 4.85 +/- 0.37, and 18.60 +/- 0.82) and Copilot (67.85 +/- 2.03, 4.35 +/- 0.49, and 17.10 +/- 0.72). Overall, AI-generated responses demonstrated higher mean educational quality scores than the YouTube video cohort. CONCLUSIONS: Both YouTube videos and AI-generated responses provided generally useful educational information regarding pediatric pelvic floor dysfunction. However, AI chatbots, particularly Gemini and ChatGPT, demonstrated greater educational consistency and closer alignment with contemporary pediatric urotherapy principles. AI-assisted educational tools may serve as valuable adjuncts to patient and caregiver education but should complement, rather than replace, professional medical evaluation and individualized clinical guidance. CI - Copyright (c) 2026, Altinok et al. FAU - Altinok, Volkan AU - Altinok V AD - Department of Pediatric Surgery, Ordu Universitesi, Ordu, TUR. FAU - Altinok, Ecem I AU - Altinok EI AD - Department of Pediatrics, Ordu Universitesi, Ordu, TUR. LA - eng PT - Journal Article DEP - 20260710 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13453056 OTO - NOTNLM OT - ai-based chatbots OT - artificial intelligence in medicine OT - dysfunctional voiding OT - pediatrics and child health OT - pelvic floor dysfunction OT - pelvic floor exercise OT - youtube videos COIS- Human subjects: All authors have confirmed that this study did not involve human participants or tissue. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/10 06:37 MHDA- 2026/08/10 06:38 PMCR- 2026/07/10 CRDT- 2026/08/10 03:51 PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/10 06:38 [medline] PHST- 2026/08/10 06:37 [pubmed] PHST- 2026/08/10 03:51 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.7759/cureus.112387 [doi] PST - epublish SO - Cureus. 2026 Jul 10;18(7):e112387. doi: 10.7759/cureus.112387. eCollection 2026 Jul. PMID- 42572658 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260826 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Effects of exercise interventions on adolescents with mild to moderate scoliosis: a meta-analysis. PG - e21355 LID - 10.7717/peerj.21355 [doi] LID - e21355 AB - BACKGROUND: Adolescent idiopathic scoliosis (AIS) is a prevalent spinal deformity that impairs physical function and quality of life. While supervised exercise is recommended for moderate cases, its effectiveness remains debated. This meta-analysis evaluates the impact of exercise therapy on Cobb angle, trunk rotation (ATR), and quality of life (QoL) in AIS patients. METHODS: We systematically searched PubMed, Web of Science, EBSCO and China National Knowledge Infrastructure (CNKI) databases from inception to October 2025 for randomized controlled trials (RCTs) investigating exercise in AIS. Study quality was assessed using the PEDro scale. Data synthesis involved pooling effect sizes, conducting subgroup analyses, and assessing publication bias using Stata 18. RESULTS: A total of 26 studies (21 RCT and five controlled trials) were included in the meta-analysis. The exercise intervention demonstrated statistically significant improvements across multiple functional domains: reduced the Cobb angle (Hedge's = 1.22, 95% CI [0.90-1.53]), improved the ATR (Hedge's systematically searched 1.25, 95% CI [0.74-1.76]), and enhanced QoL (Hedge's systematically searched 0.73, 95% CI [0.38-1.09]). Subgroup analyses further indicated that Schroth-based training (Hedge's = 1.304) and combined approaches (e.g., exercise with orthotic management) yielded the most favorable outcomes. Importantly, both short-term (/=25 weeks, >/=5 sessions/week) intervention durations demonstrated significant clinical efficacy. CONCLUSION: Exercise therapy demonstrates significant potential as a fundamental conservative intervention for improving spinal morphology, function, and quality of life in adolescents with idiopathic scoliosis. The current evidence supports its integration into primary clinical management protocols. Future research should focus on conducting multi-center randomized controlled trials to validate long-term efficacy and to establish optimal, individualized intervention protocols. CI - (c)2026 Liu et al. FAU - Liu, Qing AU - Liu Q AD - School of Physical Education, Central China Normal University, Wuhan, China. FAU - Xu, Chengli AU - Xu C AD - School of Physical Education, Central China Normal University, Wuhan, China. FAU - Li, Jia AU - Li J AD - School of Physical Education, Central China Normal University, Wuhan, China. FAU - Tian, Jing AU - Tian J AD - School of Physical Education, Central China Normal University, Wuhan, China. FAU - Xue, Chenxu AU - Xue C AD - Hebei Academy of Fine Arts, Shijiazhuang, China. FAU - Yu, Tenghao AU - Yu T AD - College of Life Science, Henan Normal University, Xinxiang, China. FAU - Dong, Kuan AU - Dong K AD - School of Physical Education, Central China Normal University, Wuhan, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260806 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Scoliosis/therapy MH - Adolescent MH - *Exercise Therapy/methods MH - *Quality of Life MH - Randomized Controlled Trials as Topic MH - Treatment Outcome PMC - PMC13453138 OTO - NOTNLM OT - Adolescent scoliosis OT - Axial trunk rotation OT - Cobb angle OT - Exercise interventions OT - Meta-analysis OT - Quality of life COIS- The authors declare there are no competing interests. EDAT- 2026/08/10 06:37 MHDA- 2026/08/10 06:38 PMCR- 2026/08/06 CRDT- 2026/08/10 03:50 PHST- 2025/07/14 00:00 [received] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/08/10 06:38 [medline] PHST- 2026/08/10 06:37 [pubmed] PHST- 2026/08/10 03:50 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 21355 [pii] AID - 10.7717/peerj.21355 [doi] PST - epublish SO - PeerJ. 2026 Aug 6;14:e21355. doi: 10.7717/peerj.21355. eCollection 2026. PMID- 42571161 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260809 LR - 20260826 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 14 IP - 8 DP - 2026 Aug TI - Association of Mental Health, Quality of Life, and Sport Specialization Using the Wisconsin Sport Specialization Questionnaire Among Adolescent Athletes. PG - 23259671261467554 LID - 10.1177/23259671261467554 [doi] LID - 23259671261467554 AB - BACKGROUND: Higher sport specialization levels have been associated with increased mental health issues. A recently validated questionnaire, the Wisconsin Sport Specialization Questionnaire (WISSQ), may provide clarity about the degree of sport specialization to investigate associations with mental health/quality of life (QoL) among adolescent athletes. PURPOSE: To examine the association of sports specialization, as measured by the WISSQ, and mental health/QoL outcomes among uninjured adolescent athletes, as well as the effect of age on the interaction between mental health/QoL outcomes and sport specialization. STUDY DESIGN: Cross-sectional study; Level of evidence, 2. METHODS: During the preseason assessment, performed in July and August from 2023 to 2025, participants completed the WISSQ and the Patient-Reported Outcomes Measurement Information System (PROMIS) Global 25 (Version 1.1). A multiple linear regression model was constructed that evaluated the association between 6 PROMIS domains and WISSQ ratings, adjusting for age, sex, and self-reported physical activity volume. To address the secondary purpose, linear regression models with an interaction term were used to examine the association between each PROMIS domain and age with sport specialization. RESULTS: A total of 251 uninjured adolescent athletes completed the study (mean +/- SD age, 15.9 +/- 1.4 years). The mean WISSQ rating was 54.1 (SD, 15.4). Results from the multivariable linear regression model indicated that higher depressive symptoms (beta = 0.46; 95% CI, 0.16-0.76; P = .003) and pain interference ratings (beta = 0.30; 95% CI, 0.02-0.57; P = .03) were significantly associated with higher WISSQ ratings, after adjusting for baseline physical activity, age, sex, and history of anxiety or depression diagnosis. For the secondary purpose, there was a significant interaction between fatigue and age group on sport specialization (beta coefficient = 0.49; 95% CI, 0.02-0.95; P = .04). The relationship between fatigue and sport specialization differed by age: a stronger association occurred among older adolescents than younger adolescents. There were no other age x QoL interactions. CONCLUSION: This study demonstrated that higher depressive symptoms and pain interference ratings were significantly associated with higher WISSQ ratings. In addition, there was a significant interaction between fatigue and age group, with a stronger association identified among older adolescents. Higher specialized and older adolescent athletes may be more at risk for developing mental health/QoL concerns and may benefit from more targeted screening. CI - (c) The Author(s) 2026. FAU - Meyers, Rachel AU - Meyers R AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. FAU - Petersen, Sarah AU - Petersen S AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Hogg-Cornejo, Veronica AU - Hogg-Cornejo V AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Sweeney, Emily AU - Sweeney E AUID- ORCID: 0000-0002-5546-4668 AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Armento, Aubrey AU - Armento A AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Howell, David AU - Howell D AUID- ORCID: 0000-0002-2955-0191 AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Walker, Gregory AU - Walker G AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. LA - eng GR - R13 AR080451/AR/NIAMS NIH HHS/United States GR - UL1 TR002535/TR/NCATS NIH HHS/United States GR - R01 NS100952/NS/NINDS NIH HHS/United States GR - K12 TR004412/TR/NCATS NIH HHS/United States GR - R03 HD094560/HD/NICHD NIH HHS/United States GR - UM1 TR004399/TR/NCATS NIH HHS/United States GR - R43 NS108823/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20260806 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC13451724 OTO - NOTNLM OT - WISSQ OT - adolescence OT - mental health OT - sport specialization COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: Research reported in this publication was supported by the Denver Broncos Foundation. The funding source played no role in the research design, data collection, data analysis, or interpretation of results. Unrelated to this study, D.H. has received research support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03HD094560,), the National Institute of Neurological Disorders and Stroke (R01NS100952, R43NS108823), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (1R13AR080451), the 59th Medical Wing Department of the Air Force, MINDSOURCE Brain Injury Network, the Tai Foundation, and the Colorado Clinical and Translational Sciences Institute (UL1 TR002535-05). A.A. has received funding from the National Center for Advancing Translational Sciences/Clinical and Translational Science Awards Program/Colorado Clinical and Translational Sciences Institute (K12 TR004412, UM1 TR004399). EDAT- 2026/08/09 06:41 MHDA- 2026/08/09 06:42 PMCR- 2026/08/06 CRDT- 2026/08/09 03:58 PHST- 2026/06/15 00:00 [received] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/08/09 06:42 [medline] PHST- 2026/08/09 06:41 [pubmed] PHST- 2026/08/09 03:58 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.1177_23259671261467554 [pii] AID - 10.1177/23259671261467554 [doi] PST - epublish SO - Orthop J Sports Med. 2026 Aug 6;14(8):23259671261467554. doi: 10.1177/23259671261467554. eCollection 2026 Aug. PMID- 42570575 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260926 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 204 DP - 2026 Nov TI - Ultrasound-based area ossification ratios for pediatric radiographic bone age: Development and internal validation of a radiation-free nomogram. PG - 113135 LID - S0720-048X(26)00483-3 [pii] LID - 10.1016/j.ejrad.2026.113135 [doi] AB - PURPOSE: Radiographic bone age (BA) assessment involves ionizing radiation, limiting its utility in frequent longitudinal follow-up. This study developed and internally validated a radiation-free nomogram based on multi-site two-dimensional ultrasound area ossification ratios (ORs) to assess Zhonghua-05 (RUS-CHN) radiographic bone age and predicted adult height (PAH), evaluating its incremental value over chronological age. METHODS: In this single-center prospective study (August 2024 approximately December 2025), 1,053 children aged 3-15 years were randomized into training and validation sets (7:3). Ultrasound area ORs of the left distal radius, ulna, and femur were calculated. Using radiographic RUS-CHN BA as the reference standard, predictor variables were selected via LASSO regression to construct the nomogram. Model performance was evaluated across the cohort and within developmental discordance subgroups (advanced/delayed maturation). RESULTS: Ultrasound OR measurements showed excellent reproducibility (ICC > 0.88). In the validation set, the nomogram predicted RUS-CHN BA with a mean absolute error (MAE) of 2.94 months (RMSE = 3.67 months, R(2) = 0.989). Crucially, in children with advanced or delayed maturation, the nomogram reduced BA prediction MAE by over 60 % compared to a baseline clinical feature model. The secondary model for PAH achieved an MAE of 0.63 cm. CONCLUSIONS: Multi-site ultrasound area ORs provide a highly reproducible, radiation-free index of skeletal maturity. As an internally validated, standard-specific research tool, the nomogram estimated RUS-CHN radiographic BA and corrected age-anchoring bias in children with discordant maturation. Because its numeric calibration is specific to the RUS-CHN standard, external multicenter and longitudinal validation is required before clinical use. ABBREVIATIONS: BA, Bone age; BMI, Body mass index; CI, Confidence interval; GP, Greulich Pyle; ICC, Intraclass correlation coefficient; LASSO, Least absolute shrinkage and selection operator; LoA, Limits of agreement; MAE, Mean absolute error; MPH, Mid‑parental height; OR, Area ossification ratio; PAH, Predicted adult height; QC, Quality control; RMSE, Root mean square error; RUS‑CHN, Radius, ulna, and short bones RUS skeletal‑maturity score, Chinese standard; SOP, Standard operating procedure; TRIPOD, Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Deng, Yongzhi AU - Deng Y AD - School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China. FAU - Qiang, Lu AU - Qiang L AD - Department of Radiology, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - Wang, Tailong AU - Wang T AD - Department of Ultrasound, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - Zheng, Haijun AU - Zheng H AD - Department of Radiology, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - He, Yucheng AU - He Y AD - Department of Radiology, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - Li, Yifang AU - Li Y AD - Academy for Engineering and Technology, Fudan University, Shanghai 200433, China. FAU - Zhu, Weihong AU - Zhu W AD - Department of Ultrasound, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. Electronic address: zhu_wei_hong@126.com. FAU - Li, Yudan AU - Li Y AD - Department of Ultrasound, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong 518000, China. Electronic address: liyudan2026@163.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20260805 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - *Nomograms MH - Child MH - Ultrasonography/methods MH - Reproducibility of Results MH - Child, Preschool MH - Female MH - Male MH - *Osteogenesis/physiology MH - Adolescent MH - Prospective Studies OTO - NOTNLM OT - Area ossification ratio OT - Bone age OT - LASSO OT - Nomogram OT - Predicted adult height OT - RUS-CHN OT - Ultrasound COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/09 00:43 MHDA- 2026/09/26 05:34 CRDT- 2026/08/08 18:07 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/08/09 00:43 [pubmed] PHST- 2026/08/08 18:07 [entrez] AID - S0720-048X(26)00483-3 [pii] AID - 10.1016/j.ejrad.2026.113135 [doi] PST - ppublish SO - Eur J Radiol. 2026 Nov;204:113135. doi: 10.1016/j.ejrad.2026.113135. Epub 2026 Aug 5. PMID- 42570559 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261009 IS - 1528-3984 (Electronic) IS - 0197-4572 (Linking) VI - 73 DP - 2026 Oct TI - Post-pandemic aging in Taiwan: Social networks, intergenerational relationships, and quality of life. PG - 104218 LID - S0197-4572(26)00423-4 [pii] LID - 10.1016/j.gerinurse.2026.104218 [doi] AB - PURPOSE: In Taiwan's post-COVID-19 context, universal National Health Insurance (NHI) and broad provider choice may contribute to information asymmetries that influence how older adults seek and navigate care. This cross-sectional study examined the associations among social network support (SNS), intergenerational relationships (IRs), healthcare-seeking behavior attitudes (HSBA), and quality of life (QoL) in community-dwelling older adults in northern Taiwan. METHODS: A total of 150 participants (mean age = 73.5 +/- 5.9 years) completed a newly developed and validated HSBA scale, a validated SNS instrument culturally adapted for older adults, a culturally adapted and validated IR measure, and a Taiwan-specific QoL measure. Analyses included descriptive statistics, Pearson correlations, prespecified subgroup comparisons, and multivariable linear regression analyses (two-tailed alpha = .05). RESULTS: All variables were positively correlated. QoL showed the strongest association with SNS (r = 0.64, p < .001), followed by IRs (r = 0.51) and HSBA (r = 0.29). In the multivariable models, regular exercise independently predicted higher HSBA, SNS, and QoL, whereas stronger IRs were associated with having more grandchildren and receiving daily telephone contact from non-cohabiting children. CONCLUSIONS: Among community-dwelling older adults in northern Taiwan, SNS was the strongest correlate of QoL. The findings support the inclusion of social connectedness, exercise participation, and intergenerational contact in routine gerontological nursing assessment. Because this study used a cross-sectional design, no causal or intervention-related interpretations can be made. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Wu, Hsiao-Ying AU - Wu HY AD - Department of Nursing, Chang Gung University of Science and Technology, No. 261 Wenhua 1st Rd. Guishan District, Taoyuan City, 333, R.O.C., Taiwan. Electronic address: hywu@mail.cgust.edu.tw. LA - eng PT - Journal Article DEP - 20260808 PL - United States TA - Geriatr Nurs JT - Geriatric nursing (New York, N.Y.) JID - 8309633 SB - IM MH - Humans MH - Taiwan/epidemiology MH - *Quality of Life/psychology MH - Aged MH - Cross-Sectional Studies MH - Female MH - *Intergenerational Relations MH - Male MH - *Social Support MH - Pandemics MH - Aged, 80 and over MH - *Patient Acceptance of Health Care/statistics & numerical data MH - *Aging/psychology MH - Independent Living MH - Surveys and Questionnaires OTO - NOTNLM OT - Healthcare-seeking behavior OT - Intergenerational relationships OT - Older adults OT - Quality of life OT - Social networks COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/09 00:43 MHDA- 2026/10/09 05:30 CRDT- 2026/08/08 18:07 PHST- 2025/12/29 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/10/09 05:30 [medline] PHST- 2026/08/09 00:43 [pubmed] PHST- 2026/08/08 18:07 [entrez] AID - S0197-4572(26)00423-4 [pii] AID - 10.1016/j.gerinurse.2026.104218 [doi] PST - ppublish SO - Geriatr Nurs. 2026 Oct;73:104218. doi: 10.1016/j.gerinurse.2026.104218. Epub 2026 Aug 8. PMID- 42551383 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 269 DP - 2026 Sep TI - Fatigue in adolescent girls is linked to heavy menstrual bleeding, meal skipping and nicotine use - not iron deficiency. PG - 107568 LID - S0001-6918(26)01369-7 [pii] LID - 10.1016/j.actpsy.2026.107568 [doi] AB - Fatigue is common among adolescent girls, and iron deficiency is often considered a potential contributing factor. However, the association between iron status and self-reported fatigue in this population remains insufficiently understood. In a cross-sectional study of 485 post-menarchal girls aged 15-19 years, we examined associations between iron status, menstrual health, lifestyle factors, fatigue, and quality of life. Participants completed validated measures of fatigue (Pediatric Quality of Life Multidimensional Fatigue Scale) and quality of life (KIDSCREEN-10), and provided blood samples for ferritin and hemoglobin assessment. Iron deficiency was present in 37.7% of participants and anemia in 7.7%. Neither iron deficiency nor anemia was associated with fatigue or quality of life in crude analyses. In contrast, heavy menstrual bleeding, daily nicotine use, and skipping breakfast or school lunch were associated with higher fatigue and lower quality of life. After adjustment for potential confounders, higher ferritin and hemoglobin levels were associated with greater fatigue, while heavy menstrual bleeding remained consistently associated with fatigue. These findings suggest that fatigue in adolescent girls is more closely related to menstrual health and everyday behavioral factors than to iron status. The results support a multidimensional perspective on adolescent fatigue and highlight the importance of considering behavioral and psychosocial influences when assessing fatigue and well-being. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Stubbendorff, Anna AU - Stubbendorff A AD - Nutritional Epidemiology, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. Electronic address: anna.stubbendorff@med.lu.se. FAU - Borgfors, Alice AU - Borgfors A AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Bolmsjo, Beata Borgstrom AU - Bolmsjo BB AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Vinge, Fredrik AU - Vinge F AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Midlov, Patrik AU - Midlov P AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Wolff, Moa AU - Wolff M AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. LA - eng PT - Journal Article DEP - 20260804 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 RN - 9007-73-2 (Ferritins) SB - IM MH - Humans MH - Female MH - Adolescent MH - *Fatigue/epidemiology/etiology/blood MH - Cross-Sectional Studies MH - Quality of Life MH - *Iron Deficiencies MH - *Menorrhagia/epidemiology/complications MH - Ferritins/blood MH - Young Adult MH - *Anemia, Iron-Deficiency/epidemiology MH - *Tobacco Use/epidemiology MH - *Feeding Behavior/physiology OTO - NOTNLM OT - Adolescent OT - Fatigue OT - Heavy menstrual bleeding, nicotine, diet OT - Iron deficiency OT - Teenage COIS- Declaration of competing interest All authors declare no competing interests. EDAT- 2026/08/09 15:21 MHDA- 2026/08/25 05:34 CRDT- 2026/08/04 18:10 PHST- 2026/06/09 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/08/09 15:21 [pubmed] PHST- 2026/08/04 18:10 [entrez] AID - S0001-6918(26)01369-7 [pii] AID - 10.1016/j.actpsy.2026.107568 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Sep;269:107568. doi: 10.1016/j.actpsy.2026.107568. Epub 2026 Aug 4. PMID- 42551214 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261001 IS - 1532-2130 (Electronic) IS - 1090-3798 (Linking) VI - 64 DP - 2026 Sep TI - Total bilirubin-to-albumin ratio and systemic immune inflammation index as prognostic indicators in children with febrile infection-related epilepsy syndrome. PG - 20-32 LID - S1090-3798(26)00082-6 [pii] LID - 10.1016/j.ejpn.2026.07.009 [doi] AB - OBJECTIVE: Febrile infection-related epilepsy syndrome (FIRES) is associated with high mortality and poor neurological outcomes, yet reliable prognostic indicators are lacking. This study aimed to evaluate the prognostic value of inflammatory indexes in FIRES and to explore their potential role in guiding clinical management. METHODS: Children with FIRES hospitalized at the Children's Hospital affiliated to Chongqing Medical University between November 2015 and April 2024 and followed for more than 6 months were retrospectively included. Inflammatory indexes were analyzed at admission and after immunotherapy. Patients were categorized into death, KD, and non-KD survival groups according to clinical course and treatment pathway. Multivariate logistic and sequential logistic regression analyses were performed to identify prognostic factors. Receiver operating characteristic (ROC) curves and Gordon's coefficient were used to determine cut-off values. Sankey diagrams and nomograms were applied to validate prognostic stratification. RESULTS: Thirty-six children with FIRES were included (22 males; mean age 6.67 +/- 3 years). Nine patients died, none of whom received KD. The KD group had significantly higher 6-month Glasgow Outcome Scale (GOS) scores than the non-KD survival and death groups (4 +/- 1 vs. 3 +/- 1 vs. 1 +/- 0, p < 0.001). Multivariate analyses showed that total bilirubin-to-albumin ratio (TAR) at admission (18.48, 95% CI 6.86 approximately 30.09, p = 0.002) and systemic immune inflammation index (SII) after immunotherapy (-0.001, 95% CI -0.001-0, p = 0.003) were independently associated with prognosis. Cut-off values of 0.145 and 0.195 for TAR and 1292 and 1892 for SII stratified patients into distinct severity groups. Higher TAR values and lower SII values were associated with milder disease and better outcomes. Sankey diagrams and nomograms further illustrated the prognostic stratification based on TAR and SII. CONCLUSION: TAR at admission and SII after immunotherapy are practical inflammatory indexes associated with disease severity and prognosis in FIRES. These findings support further investigation of early KD initiation, particularly in patients with low TAR at admission or persistently elevated SII after immunotherapy. CI - Copyright (c) 2026 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. FAU - Wang, Juan AU - Wang J AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. FAU - Cheng, Min AU - Cheng M AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. FAU - Liu, Yongfang AU - Liu Y AD - Department of Nutrition, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. FAU - Liu, Yuhang AU - Liu Y AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. FAU - Xie, Lingling AU - Xie L AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. Electronic address: lingling_xie@hospital.cqmu.edu.cn. FAU - Jiang, Li AU - Jiang L AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. Electronic address: dr_jiangcqmu@163.com. LA - eng PT - Journal Article DEP - 20260728 PL - England TA - Eur J Paediatr Neurol JT - European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society JID - 9715169 RN - RFM9X3LJ49 (Bilirubin) RN - 0 (Serum Albumin) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Prognosis MH - *Bilirubin/blood MH - Retrospective Studies MH - Child, Preschool MH - *Inflammation/blood MH - Child MH - *Epileptic Syndromes/blood/diagnosis MH - Infant MH - *Serum Albumin/metabolism MH - *Seizures, Febrile/blood/diagnosis MH - Biomarkers/blood OTO - NOTNLM OT - Febrile infection-related epilepsy syndrome OT - Inflammation OT - Ketogenic diet OT - Prognostic biomarkers OT - Systemic immune inflammation index COIS- Conflict of interest statement The authors declare that there are no conflicts of interest regarding the publication of this paper. EDAT- 2026/08/09 15:21 MHDA- 2026/10/01 23:30 CRDT- 2026/08/04 18:05 PHST- 2026/01/07 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/10/01 23:30 [medline] PHST- 2026/08/09 15:21 [pubmed] PHST- 2026/08/04 18:05 [entrez] AID - S1090-3798(26)00082-6 [pii] AID - 10.1016/j.ejpn.2026.07.009 [doi] PST - ppublish SO - Eur J Paediatr Neurol. 2026 Sep;64:20-32. doi: 10.1016/j.ejpn.2026.07.009. Epub 2026 Jul 28. PMID- 42550836 OWN - NLM STAT- Publisher LR - 20260804 IS - 2150-136X (Electronic) IS - 2150-1351 (Linking) DP - 2026 Aug 4 TI - Closed-Chest Robotic Repair of Partial Anomalous Pulmonary Venous Connection and Sinus Venosus Atrial Septal Defect Using the Warden Technique. PG - 21501351261463481 LID - 10.1177/21501351261463481 [doi] AB - An 11-year-old patient with partial anomalous venous connection, atrial septal defect (ASD), and persistent left superior vena cava underwent a closed-chest, totally thoracoscopic robotic repair using the Warden technique. The patient was extubated in the operating room and stayed in the intensive care unit for 24 h. He was discharged home on day 5 without complications. At 1-year follow-up, the right ventricular size had improved, and tricuspid regurgitation was reduced. He remains asymptomatic and tolerates physical activity adequately. Minimally invasive robotic surgery for pediatric and congenital heart pathologies appears to be safe and feasible, potentially offering a swifter return to daily and even sports activities. FAU - Morales-Rey, Ignacio AU - Morales-Rey I AUID- ORCID: 0009-0003-6602-8225 AD - Cardiovascular Surgery Department, Hospital Clinic de Barcelona, Barcelona, Spain. RINGGOLD: 16493 AD - Cardiovascular Surgery Department, University of Barcelona, Barcelona, Spain. FAU - Sandoval, Elena AU - Sandoval E AUID- ORCID: 0000-0002-4242-5133 AD - Cardiovascular Surgery Department, Hospital Clinic de Barcelona, Barcelona, Spain. RINGGOLD: 16493 AD - Cardiovascular Surgery Department, University of Barcelona, Barcelona, Spain. FAU - Fernandez-Cisneros, Alejandro AU - Fernandez-Cisneros A AUID- ORCID: 0000-0001-9901-7408 AD - Cardiovascular Surgery Department, Hospital Clinic de Barcelona, Barcelona, Spain. RINGGOLD: 16493 AD - Cardiovascular Surgery Department, University of Barcelona, Barcelona, Spain. AD - Center for Congenital Heart Disease, Hospital Sant Joan de Deu, Barcelona, Spain. RINGGOLD: 16512 FAU - Moscoso, Bosco A AU - Moscoso BA AD - Center for Congenital Heart Disease, Hospital Sant Joan de Deu, Barcelona, Spain. RINGGOLD: 16512 FAU - Pereda, Daniel AU - Pereda D AUID- ORCID: 0000-0002-0526-8722 AD - Cardiovascular Surgery Department, Hospital Clinic de Barcelona, Barcelona, Spain. RINGGOLD: 16493 AD - Cardiovascular Surgery Department, University of Barcelona, Barcelona, Spain. AD - Center for Congenital Heart Disease, Hospital Sant Joan de Deu, Barcelona, Spain. RINGGOLD: 16512 AD - Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. LA - eng PT - Journal Article DEP - 20260804 PL - United States TA - World J Pediatr Congenit Heart Surg JT - World journal for pediatric & congenital heart surgery JID - 101518415 SB - IM EDAT- 2026/08/09 15:21 MHDA- 2026/08/09 15:21 CRDT- 2026/08/04 13:33 PHST- 2026/08/09 15:21 [medline] PHST- 2026/08/09 15:21 [pubmed] PHST- 2026/08/04 13:33 [entrez] AID - 10.1177/21501351261463481 [doi] PST - aheadofprint SO - World J Pediatr Congenit Heart Surg. 2026 Aug 4:21501351261463481. doi: 10.1177/21501351261463481. PMID- 42570408 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260822 IS - 1873-4162 (Electronic) IS - 1344-6223 (Linking) VI - 85 DP - 2026 Sep TI - The relationship between postmortem heart weight and morphometric measurements and body mass index: an investigation of forensic autopsy cases. PG - 102916 LID - S1344-6223(26)00144-6 [pii] LID - 10.1016/j.legalmed.2026.102916 [doi] AB - The postmortem evaluation of heart weight and morphometric measurements presents challenges, highlighting the need for reliable reference values. This study aimed to establish population-specific data for the Turkish population. A retrospective analysis was performed on autopsy cases aged >/=18 years between January 1, 2018, and December 31, 2019, at the relevant forensic morgue department. Statistical analyses were conducted using the Number Cruncher Statistical System. Of the included cases, 20.2% were female and 79.8% male. The mean age and body mass index were 52.32 +/- 20.29 years and 28.34 +/- 7.29 kg/m(2) in females, and 46.86 +/- 17.06 years and 26.54 +/- 5.43 kg/m(2) in males. Heart weight increased with age up to 80 years in both sexes and was independently associated with body mass index in multivariable regression analysis. The mean heart weight was 507.08 +/- 129.12 g in cardiovascular-related deaths and 410.35 +/- 128.94 g in other natural deaths. In hearts without detected cardiac pathology, the mean weight was 277.74 g in females and 350.11 g in males. Average ventricular wall thickness was 0.31 cm (right) and 1.27 cm (left). Valve circumferences were larger in males. Multivariate regression analysis revealed moderate explanatory power (R(2) = 32.5% in cases with pathology and 48.0% in those without pathology) for heart weight. This study provides population-specific reference data for postmortem heart weight and morphometric parameters within the methodological framework of a retrospective autopsy cohort in the Turkish population. These findings may support forensic autopsy practice, though further studies are needed for validation. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Tat, Emrah AU - Tat E AD - The Group Presidency of Forensic Medicine, Council of Forensic Medicine, Ministry of Justice, Antalya, Turkiye. Electronic address: ab205132@adalet.gov.tr. FAU - Sogukpinar, Veysel Osman AU - Sogukpinar VO AD - The Group Presidency of Forensic Medicine, Council of Forensic Medicine, Ministry of Justice, Van, Turkiye. Electronic address: v.o.s23@hotmail.com. FAU - Arpak, Baha Berk AU - Arpak BB AD - The Council of Forensic Medicine, Ministry of Justice, Istanbul, Turkiye. Electronic address: bahaberk@gmail.com. FAU - Uzun, Ibrahim AU - Uzun I AD - The Council of Forensic Medicine, Ministry of Justice, Istanbul, Turkiye. Electronic address: ibrahim.uzun@iuc.edu.tr. LA - eng PT - Journal Article DEP - 20260708 PL - Ireland TA - Leg Med (Tokyo) JT - Legal medicine (Tokyo, Japan) JID - 100889186 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Aged MH - *Body Mass Index MH - Adult MH - Retrospective Studies MH - Organ Size MH - Aged, 80 and over MH - Autopsy MH - *Heart/anatomy & histology MH - Adolescent MH - Turkey MH - Young Adult MH - Forensic Pathology MH - Reference Values MH - *Myocardium/pathology OTO - NOTNLM OT - Body mass index OT - Forensic autopsy OT - Heart morphometric measurements OT - Heart weight OT - Reference values OT - Turkish population COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/08 23:10 MHDA- 2026/08/22 23:43 CRDT- 2026/08/08 18:01 PHST- 2026/02/03 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/08/08 23:10 [pubmed] PHST- 2026/08/08 18:01 [entrez] AID - S1344-6223(26)00144-6 [pii] AID - 10.1016/j.legalmed.2026.102916 [doi] PST - ppublish SO - Leg Med (Tokyo). 2026 Sep;85:102916. doi: 10.1016/j.legalmed.2026.102916. Epub 2026 Jul 8. PMID- 42569675 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260808 LR - 20260813 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 19 DP - 2026 Sep TI - Creation and validation of the 8-Item Brief Emotional Eating Scale (BEES-8, version 1.0) in youth and adults. PG - 100307 LID - 10.1016/j.obpill.2026.100307 [doi] LID - 100307 AB - INTRODUCTION: Although several instruments have been developed to assess emotional eating, no measure has yet been identified that evaluates this construct based on the eight basic emotions. Assessing emotional eating is particularly important because it represents a relevant factor associated with overweight and obesity. In this context, the aim of the present study was to develop and validate the Brief Emotional Eating Scale based on the Eight Basic Emotions (BEES-8, version 1.0) in a sample of Peruvian youth and adults. METHODS: A cross-sectional psychometric study was conducted. The non-probabilistic sample consisted of 481 participants of both sexes, with a mean age of 31.72 years (SD = 12.08), recruited from Metropolitan Lima, Peru. The Brief Emotional Eating Scale (BEES-8, v1.0) and the Generalized Anxiety Disorder Scale (GAD-2) were administered. RESULTS: A second-order confirmatory factor analysis demonstrated an adequate model fit (CFI = 0.976, TLI = 0.962, SRMR = 0.029, RMSEA = 0.076). Furthermore, BEES-8 (v1.0) scores showed a positive and statistically significant correlation with generalized anxiety (r = 0.449, p < 0.001), providing evidence of validity based on relationships with other variables. Finally, the scale demonstrated adequate overall reliability (omega = 0.919). CONCLUSION: The BEES-8 (v1.0) demonstrated adequate evidence of validity and reliability for assessing emotional eating based on the eight basic emotions. It constitutes a potentially useful tool for research and for the study of eating behaviors associated with emotional states, as well as variables related to overweight, obesity, and emotional regulation. CI - (c) 2026 Published by Elsevier Inc. on behalf of Obesity Medicine Association. FAU - Javier-Aliaga, David AU - Javier-Aliaga D AD - Graduate School,Universidad Peruana Union, Lima, Peru. AD - Advanced Research Center in Neuroscience, Lifestyles, Gastrointestinal health, Obesity and Diabetes (ARCeNeLGOD), Lima, Peru. FAU - Quinteros-Zuniga, Damaris AU - Quinteros-Zuniga D AD - Graduate School,Universidad Peruana Union, Lima, Peru. LA - eng PT - Journal Article DEP - 20260724 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13450208 OTO - NOTNLM OT - Adult OT - Emotional eating OT - Factor analysis OT - Obesity OT - Validation OT - Young adult COIS- The authors declare no financial, institutional, employment, or personal conflicts of interest related to the preparation of this manuscript. EDAT- 2026/08/08 23:10 MHDA- 2026/08/08 23:11 PMCR- 2026/07/24 CRDT- 2026/08/08 06:32 PHST- 2026/06/19 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/08 23:11 [medline] PHST- 2026/08/08 23:10 [pubmed] PHST- 2026/08/08 06:32 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - S2667-3681(26)00063-X [pii] AID - 100307 [pii] AID - 10.1016/j.obpill.2026.100307 [doi] PST - epublish SO - Obes Pillars. 2026 Jul 24;19:100307. doi: 10.1016/j.obpill.2026.100307. eCollection 2026 Sep. PMID- 42569514 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260903 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Personalized breathing recommendations for anxiety relief: a data-driven exploratory approach focusing on feasibility. PG - e21483 LID - 10.7717/peerj.21483 [doi] LID - e21483 AB - Breathing exercises are widely used to alleviate anxiety, but most interventions use fixed templates of inhalation, exhalation, and repetition. This study preliminarily explores the feasibility of data-driven personalization of breathing recommendations for general individuals. We hypothesized that based on the characteristics of individual users, a data-driven method could give a feasible breathing intervention suggestion without the need of specialized hardware. A multilayer perceptron was trained on questionnaire responses to predict the inhalation, exhalation, and repetition times. The model stability was assessed using several independently trained models and exhibited high consistency with coefficients of variation below 10% across all outputs. A single-blind randomized study (N = 820), which compared the personalized recommendations to a fixed template that is known to effectively reduce anxiety, measured the outcomes in terms of anxiety reduction and user-reported satisfaction. The main analysis and subgroup analysis both detected no statistically significant differences in effectiveness between model recommendation and fixed template after applying multiple comparison corrections. However, adults aged 18-30 years with the medium anxiety level showed a moderate exploratory preference for the fixed template. These findings indicate that individual characteristics may influence the preference of breathing interventions. Overall, the results highlight the feasibility of datadriven personalization in non-medical anxiety interventions. The outcomes can still be enhanced by various methods such as collecting more training data, fine-tuning on the model, or choosing advanced machine learning or offline reinforcement learning approaches. CI - (c)2026 Zhuo. FAU - Zhuo, Dongyin AU - Zhuo D AD - Munich, Bavaria, Germany. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260804 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Anxiety/therapy MH - Adult MH - Feasibility Studies MH - Female MH - Male MH - *Breathing Exercises/methods MH - Adolescent MH - Young Adult MH - Single-Blind Method MH - Surveys and Questionnaires MH - *Precision Medicine/methods PMC - PMC13450033 OTO - NOTNLM OT - Anxiety reduction OT - Deep learning OT - Personalization COIS- The authors declare there are no competing interests. EDAT- 2026/08/08 23:10 MHDA- 2026/08/08 23:11 PMCR- 2026/08/04 CRDT- 2026/08/08 06:25 PHST- 2026/01/23 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/08/08 23:11 [medline] PHST- 2026/08/08 23:10 [pubmed] PHST- 2026/08/08 06:25 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 21483 [pii] AID - 10.7717/peerj.21483 [doi] PST - epublish SO - PeerJ. 2026 Aug 4;14:e21483. doi: 10.7717/peerj.21483. eCollection 2026. PMID- 42568752 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260808 LR - 20260926 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 8 DP - 2026 Aug TI - Vitamin E-Related Molecular Signatures in Adolescent Idiopathic Scoliosis: A Hypothesis-Generating Multi-Omics Analysis. PG - e72190 LID - 10.1002/fsn3.72190 [doi] LID - e72190 AB - Adolescent idiopathic scoliosis (AIS) involves systemic bone-metabolic dysregulation and paraspinal microenvironment remodeling, but whether nutrition-related micronutrient-associated molecular programs overlap with these alterations remains unclear. Vitamin E (VE), comprising lipid-soluble tocopherols and tocotrienols, is linked to membrane protection, lipid peroxidation control, inflammatory mediator regulation, and endothelial responses. This study examined whether VE-related molecular signatures converge on AIS-associated redox, lipid-inflammatory, vascular, and multicellular remodeling programs. Peripheral blood miRNA data (GSE235203) and bone marrow transcriptomic data (GSE110359) were integrated using HERB-based compound mapping, VE-AIS shared-target enrichment, feature prioritization, intradisease GSEA, single-cell localization, CellChat analysis, and NHANES contextualization. HERB mapping generated a VE/tocopherol-related prioritization signal, not direct evidence of VE involvement in AIS. Forty-two shared VE-AIS targets were enriched mainly in oxidative stress, glutathione/peroxidase activity, and glutathione metabolism, with additional lipid-inflammatory and vascular signals. Five prioritized genes (SOD1, GCLC, PTGS1, PTGS2, and KDR) defined redox-buffering, lipid-inflammatory, and vascular-response axes. Single-cell and CellChat analyses localized these signatures mainly to endothelial, dendritic/APC-like, MSC-like, and stromal/osteogenic populations, suggesting a predicted concave-side enrichment of inflammatory-endothelial-stromal communication. Structural analyses supported the computational plausibility of alpha-tocopherol compatibility with selected proteins, particularly PTGS2. No AIS cohort with measured VE exposure or status was analyzed. NHANES provided external clinical nutrition context rather than AIS-specific validation. Overall, VE-related signatures overlapped with redox, lipid-inflammatory, vascular-response, and multicellular remodeling programs in AIS. These findings generate testable molecular hypotheses but do not show that VE intake, tocopherol status, or supplementation modifies AIS risk, severity, or progression. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Ma, Ying AU - Ma Y AUID- ORCID: 0009-0008-9152-5609 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Han, Yuankun AU - Han Y AUID- ORCID: 0009-0004-4130-1886 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Geng, Zhizhong AU - Geng Z AUID- ORCID: 0000-0001-8000-4236 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Fang, Sitong AU - Fang S AUID- ORCID: 0009-0002-9463-8701 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Ren, Jun AU - Ren J AUID- ORCID: 0000-0002-4818-7746 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Wang, Shoujian AU - Wang S AUID- ORCID: 0009-0003-6319-6645 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - He, Tianxiang AU - He T AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Kong, Lingjun AU - Kong L AUID- ORCID: 0000-0002-6854-4202 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Fang, Min AU - Fang M AUID- ORCID: 0000-0001-5241-6460 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. AD - Institute of Tuina Shanghai Institute of Traditional Chinese Medicine Shanghai China. LA - eng PT - Journal Article DEP - 20260806 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13447955 OTO - NOTNLM OT - adolescent idiopathic scoliosis OT - oxidative stress OT - prostaglandin signaling OT - tocopherol OT - vascular response OT - vitamin E COIS- The authors declare no conflicts of interest. EDAT- 2026/08/08 12:52 MHDA- 2026/08/08 12:53 PMCR- 2026/08/06 CRDT- 2026/08/08 05:36 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/08 12:53 [medline] PHST- 2026/08/08 12:52 [pubmed] PHST- 2026/08/08 05:36 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - FSN372190 [pii] AID - 10.1002/fsn3.72190 [doi] PST - epublish SO - Food Sci Nutr. 2026 Aug 6;14(8):e72190. doi: 10.1002/fsn3.72190. eCollection 2026 Aug. PMID- 42568636 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260808 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Sensory feeding problems, pica-related behaviors, and sleep habits among children with autism spectrum disorder in palestine: a parent-reported cross-sectional study. PG - 1899150 LID - 10.3389/fped.2026.1899150 [doi] LID - 1899150 AB - BACKGROUND: Autism Spectrum Disorder (ASD) is commonly associated with feeding difficulties and sleep disturbances, yet their co-occurrence remains understudied in Arab and Palestinian contexts. Pica and broader pica-related sensory feeding behaviors are among the most clinically significant feeding problems in children with ASD, carrying serious health risks. This study examined the level of parent-reported sensory feeding problems, pica-related behaviors, and sleep habit disturbances in children with ASD attending care centers in the West Bank, Palestine, and explored their association. METHODS: A cross-sectional descriptive-correlational survey was conducted. A convenience sample of 105 parents of children with ASD was recruited from care centers in the West Bank during August 2025. Two instruments were used: a 20-item literature-informed Sensory Feeding/Pica-Related Behaviors Scale developed for this study, and a 21-item Sleep Habits Scale adapted from the Arabic scale developed and validated by Al-Merdasi. The feeding scale underwent expert content review and pilot testing, while internal consistency was assessed for both instruments in the present sample. The feeding scale was designed to describe caregiver-reported sensory feeding difficulties and pica-related behaviors rather than to establish a DSM-5-TR or ICD-11 diagnosis of pica. All sleep items were coded so that higher scores indicated greater sleep disturbance; sleep adequacy items were reverse-scored. Data were analyzed using descriptive statistics, independent-samples t-tests, one-way ANOVA with LSD post-hoc tests, and Pearson correlation in SPSS. Effect sizes were reported as Cohen's d for t-tests and partial eta(2) for ANOVA. RESULTS: Sensory feeding problems and Pica-related behaviors scores were at a moderate level overall (M = 1.946, SD = 0.307; relative weight 64.9%). Sleep habit disturbances were also moderate (M = 3.123, SD = 0.551; 62.5%), with sleep anxiety ranking highest (M = 3.507). No significant differences in Sensory feeding and pica-related behavior scores were found by any demographic variable. For sleep habits, significant differences were found by child age (F = 10.038, p = 0.001, eta(2) = 0.164), with younger children appearing to score higher, though the oldest age group was small (n = 7) and the finding should be interpreted cautiously. Significant differences were also found by child sex (t = 2.195, p = 0.030, d = 0.43), with higher sleep disturbance scores among females. A significant positive moderate correlation was found between pica-related problem scores and sleep disturbance scores (r = 0.463, p < 0.001). CONCLUSIONS: This parent-reported cross-sectional study found moderate levels of sensory feeding problems, pica-related behaviors, and sleep disturbances among children with ASD in the West Bank, Palestine, and a significant positive association between them. Because the study used convenience sampling and researcher-developed instruments with preliminary validation only, findings should be interpreted as preliminary and should not be taken as estimates of clinically diagnosed pica or sleep disturbances. They highlight the importance of integrating screening for pica-like behaviors and sleep problems within ASD services, and support the need for future longitudinal studies incorporating clinical diagnosis, gastrointestinal assessment, nutritional biomarkers, and validated measures. CI - (c) 2026 Sabbah, Namoura, Yacoub, Yacoub and Yacoub. FAU - Sabbah, Suheir AU - Sabbah S AD - Psychology Department, Al-Quds University, Jerusalem, Palestine. FAU - Namoura, Sana M AU - Namoura SM AD - Psychology Department, Al-Quds University, Jerusalem, Palestine. FAU - Yacoub, Hamzeh AU - Yacoub H AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. AD - Faculty of Medicine, Arab American University, Ramallah, Palestine. FAU - Yacoub, Zaid AU - Yacoub Z AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. AD - SurgiCore-Jerusalem, Surgical Interest Group of Jerusalem, Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. FAU - Yacoub, Rita AU - Yacoub R AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. LA - eng PT - Journal Article DEP - 20260724 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13447483 OTO - NOTNLM OT - autism spectrum disorder OT - cross-sectional study OT - feeding disorders OT - palestine OT - pica-related behaviors OT - sensory feeding problems OT - sensory processing OT - sleep habits COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/08 12:52 MHDA- 2026/08/08 12:53 PMCR- 2026/07/24 CRDT- 2026/08/08 05:28 PHST- 2026/06/03 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/08/08 12:53 [medline] PHST- 2026/08/08 12:52 [pubmed] PHST- 2026/08/08 05:28 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.3389/fped.2026.1899150 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 24;14:1899150. doi: 10.3389/fped.2026.1899150. eCollection 2026. PMID- 42568356 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260808 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Comparative profiling of amino acids in plasma and serum across children and adults using LC-MS/MS and its implications for precision nutrition. PG - 1850080 LID - 10.3389/fnut.2026.1850080 [doi] LID - 1850080 AB - OBJECTIVE: Circulating amino acids (AAs) are important biomarkers of nutritional status, metabolic homeostasis, and disease related physiological changes. However, the influence of specimen type and age on AA measurements remains incompletely understood. This study aimed to establish a robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying 29 amino acids (AAs), compare serum and plasma matrices, and investigate age related variations in healthy populations. METHODS: In a cross-sectional study, a total of 231 healthy adults (>/=18 years) and 140 children (<18 years) were recruited from the Shanghai area with a subgroup of 26 adults providing paired serum and plasma samples. Twenty-nine AA quantification was performed using LC-MS/MS with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatization. Method validation followed Clinical and Laboratory Standards Institute (CLSI) guidelines for linearity, lower limit of quantitation (LLOQ), precision, accuracy, carryover, and stability. RESULTS: The assay demonstrated excellent linearity (R (2) > 0.99), precision (CV < 15%), and accuracy (bias < 10%) with minimal carryover and acceptable LLOQs for all 29 AAs. Matrix differences and correlations were evaluated using the paired samples, while age related AA profiles were assessed in largely independent serum and plasma cohorts of pediatric and adult. Serum and plasma concentrations correlated well for most AA. However, significant matrix dependent differences were observed for several amino acids, including GABA, Ser, Tau, Sar, and Asp (R (2) < 0.5). Age related analysis revealed that most essential AAs (Leu, Ile, Trp, Phe, His, Tyr) exhibited higher median concentrations in children compared to adults in serum. Conversely, lysine and threonine were significantly higher in adult serum. In plasma, age related differences were less pronounced for essential AAs but consistent for specific non-essential AAs. Bubble plot showed Cit, Arg, and Gln were positively associated with age, while GABA was negatively associated with age. CONCLUSION: The validated LC-MS/MS platform provides a reliable platform for nutritional biomarker research. Matrix selection and age are critical factors in AA interpretation, offering valuable insights for clinical diagnostics and translational metabolomics research. CI - Copyright (c) 2026 Ma, Liu, Huangfu, Zhou and Zheng. FAU - Ma, Yanhui AU - Ma Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Liu, Yi AU - Liu Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Huangfu, Yuchan AU - Huangfu Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhou, Yunlan AU - Zhou Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zheng, Yingxia AU - Zheng Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Faculty of Medical Laboratory Science, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Institute of Artificial Intelligence Medicine, Shanghai Academy of Experimental Medicine, Shanghai, China. LA - eng PT - Journal Article DEP - 20260724 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13447054 OTO - NOTNLM OT - LC-MS/MS OT - age OT - amino acids OT - fasting serum OT - plasma COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/08 12:52 MHDA- 2026/08/08 12:53 PMCR- 2026/07/24 CRDT- 2026/08/08 04:46 PHST- 2026/04/08 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/08 12:53 [medline] PHST- 2026/08/08 12:52 [pubmed] PHST- 2026/08/08 04:46 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1850080 [doi] PST - epublish SO - Front Nutr. 2026 Jul 24;13:1850080. doi: 10.3389/fnut.2026.1850080. eCollection 2026. PMID- 42568081 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Aug 8 TI - Digital odontometric analysis for sex estimation in Egyptian adolescents. LID - 10.1186/s12903-026-09486-x [doi] LID - 1384 AB - OBJECTIVES: Reliable sex estimation using dental metrics has important implications for clinical assessment and forensic identification, particularly in adolescents where skeletal indicators may be limited. This study aimed to validate the accuracy and clinical applicability of a digital odontometric model for sex estimation in an Egyptian adolescent population. METHODS: A total of 150 dental casts from individuals aged 12-19 years were digitized using a high-resolution three-dimensional scanner. Mesiodistal and buccolingual dimensions of the permanent first molars, mesiodistal widths of the maxillary canines, and intercanine, interpremolar, and intermolar arch widths were obtained using Facad Ortho tracing software. Statistical comparisons between sexes were performed, and discriminant function analysis was applied to construct and validate a predictive model for sex estimation. RESULTS: All measured parameters demonstrated significantly higher mean values in males compared with females (p < 0.05). The buccolingual and mesiodistal dimensions of the maxillary first molar exhibited the greatest sexual dimorphism (26.95% and 25.98%, respectively). The developed discriminant function model achieved a prediction accuracy of 97.8% for males and 100% for females. CONCLUSIONS: Digital odontometric analysis provides a promising approach for assessing sexual dimorphism in adolescents, pending external validation. This promising model may serve as a reliable adjunct for clinical evaluation and forensic identification within population-specific contexts pending further multicenter validation. CLINICAL RELEVANCE: Digital measurement of tooth and arch dimensions enables objective, standardized assessment of sex-related differences, supporting its integration into orthodontic diagnostics, treatment planning, and forensic casework where conventional skeletal indicators may be unavailable or inconclusive. CI - (c) 2026. The Author(s). FAU - Hadwa, Shimaa M AU - Hadwa SM AD - Pediatric Dentistry, Oral Health, and Preventive Dentistry Department, Faculty of Dentistry, Tanta University, Tanta, 31527, Egypt. shimaa.hadwa@dent.tanta.edu.eg. FAU - Alawy, Safa B AU - Alawy SB AD - Orthodontics Department, Faculty of Dentistry, Tanta University, Tanta, Egypt. FAU - Kabbash, Ibrahim A AU - Kabbash IA AD - Public Health & Community Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt. FAU - El-Desouky, Shaimaa S AU - El-Desouky SS AD - Pediatric Dentistry, Oral Health, and Preventive Dentistry Department, Faculty of Dentistry, Tanta University, Tanta, 31527, Egypt. LA - eng PT - Journal Article PT - Validation Study DEP - 20260808 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Adolescent MH - *Odontometry/methods MH - Egypt MH - Male MH - Child MH - Female MH - Young Adult MH - Imaging, Three-Dimensional MH - Discriminant Analysis MH - Models, Dental MH - Sex Characteristics MH - *Sex Determination Analysis/methods MH - Image Processing, Computer-Assisted MH - Dental Arch/anatomy & histology PMC - PMC13452096 OTO - NOTNLM OT - Arch width OT - Forensic odontology OT - Odontometric analysis OT - Sex OT - Sexual dimorphism COIS- Declarations. Ethical approval and consent to participate: Ethical approval for this study was obtained from the Research Ethics Committee, Faculty of Dentistry, Tanta University (Approval code: R-PED-5-24-3108), in accordance with the principles of the Declaration of Helsinki and its subsequent amendments. The study was retrospective and non-interventional in nature. Written informed consent to participate was obtained from all participants and/or their legal guardians at the time of record and dental cast collection, permitting the use of anonymized clinical data and models for research purposes. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/08 00:37 MHDA- 2026/08/08 12:52 PMCR- 2026/08/08 CRDT- 2026/08/07 23:57 PHST- 2026/01/17 00:00 [received] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/08/08 12:52 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 23:57 [entrez] PHST- 2026/08/08 00:00 [pmc-release] AID - 10.1186/s12903-026-09486-x [pii] AID - 9486 [pii] AID - 10.1186/s12903-026-09486-x [doi] PST - epublish SO - BMC Oral Health. 2026 Aug 8;26(1):1384. doi: 10.1186/s12903-026-09486-x. PMID- 42568061 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20261027 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 15 IP - 16 DP - 2026 Aug 18 TI - Dietary Approaches to Stop Hypertension Score Trajectories From Early to Middle Adulthood and Coronary Artery Calcium Progression in Middle Age. PG - e044564 LID - 10.1161/JAHA.125.044564 [doi] LID - e044564 AB - BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet reduces blood pressure and cardiovascular disease risk, but its impact on later coronary artery calcium (CAC) progression is unclear. This study aimed to identify DASH score trajectories from early to middle adulthood and assess their association with CAC progression in middle age, exploring the potential mediating factors. METHODS: We conducted a prospective analysis of 2238 Black and White adults who were aged 18 to 30 years at CARDIA (Coronary Artery Risk Development in Young Adults) baseline and were followed from study year 20 to year 25. DASH score trajectories from early to middle adulthood were determined using latent class analysis. The primary end point was CAC progression, a validated measure of plaque progression, defined as a >2.5 square root increase in CAC score between years 20 and 25. RESULTS: Two distinct DASH score trajectories were identified: the low-increasing and high-decreasing trajectories. In the fully adjusted model, participants in the high-decreasing trajectory had a 21% lower risk of CAC progression compared with those in the low-increasing trajectory (hazard ratio, 0.79 [95% CI, 0.65-0.98]; P=0.028). The association was partially mediated by diastolic blood pressure, insulin, uric acid, and lipid profiles. CONCLUSIONS: DASH score trajectories vary from early to middle adulthood. Maintaining high adherence to the DASH diet from early to middle adulthood is associated with reduced CAC progression in middle age, partially mediated by cardiometabolic risk factors. These findings support the importance of long-term adherence to a healthy dietary pattern for cardiovascular disease primary prevention. REGISTRATION: URL: https://www.clinicaltrials.gov; unique identifier: NCT00005130. FAU - Li, Xiong-Zhi AU - Li XZ AUID- ORCID: 0000-0001-8000-0227 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Xiong, Zhuo-Chao AU - Xiong ZC AUID- ORCID: 0000-0001-7520-409X AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Wang, Xin-Yi AU - Wang XY AUID- ORCID: 0009-0000-2285-6772 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Yu, Jin-Bo AU - Yu JB AUID- ORCID: 0000-0003-4341-3131 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhou, Jian AU - Zhou J AUID- ORCID: 0000-0002-5188-7129 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhong, Dong-Xiang AU - Zhong DX AUID- ORCID: 0000-0002-3997-7578 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Wu, Yi-Zhang AU - Wu YZ AUID- ORCID: 0000-0002-9693-8516 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhang, Bao-Wei AU - Zhang BW AUID- ORCID: 0000-0001-7043-0370 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhang, You-Ming AU - Zhang YM AUID- ORCID: 0000-0002-5014-8228 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Xia, Guang AU - Xia G AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Fan, Feng-Hua AU - Fan FH AUID- ORCID: 0009-0009-0049-6089 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Xie, Xin AU - Xie X AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Chen, Jie AU - Chen J AUID- ORCID: 0009-0003-2462-9559 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Song, Jie AU - Song J AUID- ORCID: 0009-0009-3238-4962 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhao, Jie AU - Zhao J AUID- ORCID: 0009-0004-3898-3505 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Li, Xiao-Rong AU - Li XR AUID- ORCID: 0000-0002-7295-655X AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Yang, Bing AU - Yang B AUID- ORCID: 0000-0001-5042-9305 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. LA - eng SI - ClinicalTrials.gov/NCT00005130 PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20260807 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 SB - IM MH - Humans MH - *Dietary Approaches To Stop Hypertension MH - Male MH - Disease Progression MH - Female MH - *Coronary Artery Disease/prevention & control/diagnostic imaging/epidemiology MH - Adult MH - Prospective Studies MH - *Vascular Calcification/prevention & control/diagnostic imaging/epidemiology MH - Young Adult MH - Adolescent MH - Middle Aged MH - Blood Pressure MH - Risk Factors MH - *Hypertension/diet therapy MH - Age Factors MH - *Coronary Vessels/diagnostic imaging MH - Risk Assessment MH - Time Factors MH - United States/epidemiology PMC - PMC13695727 OTO - NOTNLM OT - cardiometabolic risk OT - cardiovascular disease OT - coronary artery calcium OT - diet OT - dietary approaches to stop hypertension OT - primary prevention COIS- None. EDAT- 2026/08/08 00:37 MHDA- 2026/08/19 17:43 PMCR- 2026/08/07 CRDT- 2026/08/07 23:54 PHST- 2026/08/19 17:43 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 23:54 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - JAH370941 [pii] AID - 10.1161/JAHA.125.044564 [doi] PST - ppublish SO - J Am Heart Assoc. 2026 Aug 18;15(16):e044564. doi: 10.1161/JAHA.125.044564. Epub 2026 Aug 7. PMID- 42567969 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - First-stage assessment of AI-based anatomical measurement accuracy for the Cameriere European dental age estimation method. PG - 3951-3959 LID - 10.1007/s00414-026-03950-7 [doi] AB - AIM: This study represents the first methodological stage of a broader AI-assisted Cameriere European dental age estimation workflow. The aim of this first stage was to evaluate the performance of YOLOv8-based deep learning models in automatically detecting the anatomical landmarks and apical structures required for the Cameriere European method. Rather than directly estimating dental age, the proposed system was designed to automate the measurement-related inputs needed for subsequent Cameriere European-based age calculation. METHODS: This retrospective first-stage validation study included 4,050 panoramic radiographs of boys and girls aged 5-13 years. Two YOLOv8-based models were developed to automate the anatomical measurement components of the Cameriere European method: a YOLOv8x-pose model for open-apex landmark detection and tooth-length reference point localization, and a YOLOv8x-seg model for closed-apex segmentation. Owing to model-specific anatomical eligibility criteria, 3,796 images were used for the pose model and 2,971 images for the segmentation model. Image annotations were performed using CranioCatch software according to a standardized annotation protocol. Model outputs were compared with manual reference annotations to evaluate landmark detection, measurement-related localization, and apical segmentation performance. RESULTS: In the YOLOv8x-pose model, mAP_0.5 = 0.963 and mAP_0.5:0.95 = 0.842 were achieved; recall was 0.928 and precision was 0.918. Error metrics were MAE = 0.0032, RMSE = 0.0045, SMAPE = 2.09%, and the coefficient of determination R(2) = 0.9992. CONCLUSION: YOLOv8-based pose and segmentation models demonstrated technical feasibility for automating anatomical measurement extraction required for the Cameriere European dental age estimation method. Because dental age was not calculated in this first-stage analysis, the findings should be interpreted as measurement-level validation rather than complete dental age-estimation accuracy. Further validation is required to integrate AI-derived measurements into the Cameriere European formula and to compare AI-assisted dental age estimates with manual Cameriere-based assessment and chronological age. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Karauguz, Zehra Selin AU - Karauguz ZS AUID- ORCID: 0009-0007-6993-2585 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Necmettin Erbakan University Yaka Mah, Beysehir Avenue, Baglarbasi Street No: 4, 42090, Meram, Konya, Turkiye. zehraselinkarauguz@gmail.com. FAU - Altan, Halenur AU - Altan H AUID- ORCID: 0000-0003-3648-5989 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Necmettin Erbakan University Yaka Mah, Beysehir Avenue, Baglarbasi Street No: 4, 42090, Meram, Konya, Turkiye. LA - eng GR - 25DU24001/Necmettin Erbakan Universitesi/ PT - Journal Article PT - Validation Study DEP - 20260808 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Child MH - Adolescent MH - Female MH - Child, Preschool MH - Radiography, Panoramic MH - Retrospective Studies MH - Male MH - *Anatomic Landmarks/diagnostic imaging MH - *Deep Learning MH - Image Processing, Computer-Assisted MH - Detection Algorithms MH - Tooth Apex/diagnostic imaging/growth & development OTO - NOTNLM OT - Artificial intelligence OT - Cameriere European method OT - Deep learning OT - Dental age estimation OT - YOLOv8 COIS- Declarations. Ethical approval: The study protocol was approved by the Non-Drug and Non-Medical Device Research Ethics Committee of the Faculty of Dentistry, Necmettin Erbakan University (Decision No: 2025/584; Meeting No: 51; Date: 24/04/2025). Informed consent: The requirement for informed consent was waived due to the retrospective nature of the study and the use of anonymized data. Research involving human participants and/or animals: This retrospective study involved previously collected radiographic data. Conflicts of interest: The authors declare that they have no conflict of interest. Data availability: The datasets generated and/or analysed during the current study are not publicly available due to institutional and ethical restrictions on patient radiographic data but are available from the corresponding author on reasonable request. EDAT- 2026/08/08 00:37 MHDA- 2026/10/12 17:30 CRDT- 2026/08/07 23:42 PHST- 2026/02/26 00:00 [received] PHST- 2026/08/01 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 23:42 [entrez] AID - 10.1007/s00414-026-03950-7 [pii] AID - 10.1007/s00414-026-03950-7 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):3951-3959. doi: 10.1007/s00414-026-03950-7. Epub 2026 Aug 8. PMID- 42567553 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260816 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Aug 7 TI - Context-specific predictors of mortality and the performance of paediatric sepsis scores in Tanzanian children: a secondary analysis of a prospective cohort study. LID - 10.1136/bmjpo-2026-004856 [doi] LID - e004856 AB - INTRODUCTION: Sepsis is a significant cause of global child mortality, disproportionately affecting resource-limited settings (RLS). Although clinical scores have been proposed in RLS, few have been externally validated. This study aimed to identify risk factors for mortality among Tanzanian children with sepsis and test three paediatric clinical scores in an RLS. METHODS: We conducted a secondary analysis of a prospective cohort study of 755 children (28 days to 14 years) with sepsis in the Emergency Department at Muhimbili National Hospital, Tanzania (July 2022-November 2024). Demographic, clinical and outcome data were collected. We performed multivariable logistic regression to identify independent predictors of in-hospital mortality. We then tested three clinical scores, Lambarene Organ Dysfunction Score (LODS), Blantyre quick Sequential Organ Failure Assessment (BqSOFA) and Phoenix Sepsis Score (PSS), using sensitivity, specificity and area under the receiver operating characteristic curve (AUC). RESULTS: In-hospital mortality was 20% (n=148); independent predictors included age, malnutrition, HIV status, referral status and delayed presentation (p<0.001). All three scores demonstrated strong discrimination for mortality (LODS AUC 0.79, 95% CI 0.75 to 0.83; BqSOFA AUC 0.75, 95% CI 0.71 to 0.79; PSS AUC 0.75, 95% CI 0.70 to 0.79) and differences between scores were not statistically significant (p=0.066). LODS showed high sensitivity (93%) and negative predictive value (96%). BqSOFA and PSS demonstrated high specificity (93% and 91%) and positive predictive values (51% and 56%), but low sensitivity (28% and 44%). CONCLUSIONS: Multiple clinical and sociodemographic factors were independently associated with mortality in children with sepsis. LODS demonstrated high sensitivity, while BqSOFA and PSS demonstrated high specificity; the scores' discriminative ability for mortality was not statistically significant. The identification of simple risk factors and moderately performing clinical scores provides a valuable opportunity to develop context-specific risk stratification tools for paediatric sepsis in RLS. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Sorensen, Abigail AU - Sorensen A AUID- ORCID: 0000-0001-8444-4968 AD - Pediatrics, UCSF, San Francisco, California, USA abigail.sorensen@ucsf.edu. FAU - Mussa, Raya AU - Mussa R AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Sunzula, Erasto AU - Sunzula E AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Mlele, Victoria AU - Mlele V AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Oltman, Scott AU - Oltman S AD - Epidemiology and Biostatistics, UCSF, San Francisco, California, USA. FAU - Msemwa, Cecilia AU - Msemwa C AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Mathias, Lushana AU - Mathias L AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Baez-Maidana, Jazmin AU - Baez-Maidana J AD - Pediatrics, UCSF, San Francisco, California, USA. FAU - Sun, Kathleen AU - Sun K AD - Pediatrics, UCSF, San Francisco, California, USA. FAU - Mfinanga, Juma AU - Mfinanga J AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Chu, Victoria AU - Chu V AD - Pediatrics, UCSF, San Francisco, California, USA. FAU - Hooft, Anneka AU - Hooft A AD - Emergency Medicine, UCSF, San Francisco, California, USA. FAU - Mkopi, Namala AU - Mkopi N AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Kissoon, Niranjan AU - Kissoon N AD - Pediatrics, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada. FAU - Manyahi, Joel AU - Manyahi J AD - Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Sawe, Hendry AU - Sawe H AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Kortz, Teresa AU - Kortz T AD - Pediatrics, UCSF, San Francisco, California, USA. LA - eng GR - D43 TW009343/TW/FIC NIH HHS/United States GR - K23 AI144029/AI/NIAID NIH HHS/United States GR - T32 HD049303/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260807 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Tanzania/epidemiology MH - *Sepsis/mortality/diagnosis MH - Female MH - Male MH - Prospective Studies MH - Child, Preschool MH - Infant MH - *Hospital Mortality MH - Child MH - Adolescent MH - Risk Factors MH - Organ Dysfunction Scores MH - Resource-Limited Settings MH - ROC Curve MH - Infant, Newborn MH - Severity of Illness Index MH - Predictive Value of Tests MH - Sensitivity and Specificity PMC - PMC13475138 OTO - NOTNLM OT - Child OT - Child Health OT - Developing Countries OT - Low and Middle Income Countries OT - Mortality COIS- Competing interests: None declared. EDAT- 2026/08/08 00:37 MHDA- 2026/08/08 00:38 PMCR- 2026/08/07 CRDT- 2026/08/07 20:43 PHST- 2026/04/13 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/08/08 00:38 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 20:43 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 10.1136/bmjpo-2026-004856 [pii] AID - bmjpo-2026-004856 [pii] AID - 10.1136/bmjpo-2026-004856 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Aug 7;10(1):e004856. doi: 10.1136/bmjpo-2026-004856. PMID- 42567538 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1745-5065 (Electronic) IS - 1745-5057 (Print) IS - 1745-5057 (Linking) VI - 22 DP - 2026 Jan-Dec TI - A mixed methods analysis of a culturally responsive body image pilot intervention for black adolescent girls: Black girl joy. PG - 17455057261476900 LID - 10.1177/17455057261476900 [doi] LID - 17455057261476900 AB - BackgroundBlack adolescent girls develop body image within intersecting sociocultural contexts shaped by race, gender, and physical activity, yet few interventions are culturally and gender-responsive to their lived experiences.ObjectiveThis study examined the preliminary impact of Black Girl Joy, a culturally responsive body image and wellness pilot intervention, on psychosocial outcomes among Black adolescent girls.Study designExploratory mixed-methods pilot study using a single-group pre-post design.MethodsThe 7-week intervention was delivered to Black middle school girls participating in a district-based enrichment program in Southern California. Participants who completed both pre- and post-assessments (N = 14) were included in the analyses. Outcomes included body image, self-esteem, physical activity enjoyment, self-compassion, and anxiety/depressive symptoms. Prior to analysis, normality of difference scores was evaluated using the Shapiro-Wilk test. Given observed violations of normality and the small sample size, Wilcoxon signed-rank tests were conducted for all pre-post comparisons. Baseline bivariate correlations were also examined. Qualitative data were collected through three semi-structured focus groups and analyzed using inductive thematic analysis.ResultsBaseline correlations revealed a positive association between body image and self-esteem, and a negative association between self-compassion and anxiety/depressive symptoms. Wilcoxon signed-rank tests indicated no statistically significant pre-to-post changes across outcome variables; however, several outcomes showed small-to-medium effect sizes in the expected direction, including body esteem weight (r = .320), PHQ anxiety (r = .348), and self-compassion self-kindness (r = .359). Qualitative findings identified four themes: body image discussions, perceptions of physical activity, connection, and program recommendations. Participants described increased self-love, confidence, and self-kindness; enjoyment of both strength-based and expressive movement; meaningful peer and coach relationships; and a desire for greater autonomy in programming.ConclusionFindings demonstrate the feasibility and acceptability of a culturally responsive pilot intervention for Black adolescent girls. Larger, controlled studies are needed to evaluate efficacy and inform scalable implementation. FAU - Walters, Kellie AU - Walters K AUID- ORCID: 0000-0002-0892-8028 AD - Department of Kinesiology, California State University Long Beach, Long Beach, CA, USA. RINGGOLD: 14668 FAU - Johnson, Amber AU - Johnson A AD - Department of Health Science, Director for the Center for Health Equity Research, California State University Long Beach, Long Beach, CA, USA. RINGGOLD: 14668 FAU - Pope, Alexis AU - Pope A AD - Public Health, University of California, Berkeley, CA, USA. RINGGOLD: 1438 LA - eng PT - Journal Article DEP - 20260807 PL - United States TA - Womens Health (Lond) JT - Women's health (London, England) JID - 101271249 SB - IM MH - Humans MH - Female MH - *Body Image/psychology MH - Pilot Projects MH - Adolescent MH - *Self Concept MH - *Black or African American/psychology MH - California MH - Exercise/psychology MH - Body Satisfaction MH - Anxiety/psychology MH - Focus Groups MH - Depression/psychology PMC - PMC13451688 OTO - NOTNLM OT - culturally grounded programming OT - health equity OT - physical activity behavior OT - psychosocial wellbeing OT - self-compassion OT - self-esteem OT - self-perception OT - youth health disparities COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/08 00:37 MHDA- 2026/08/08 00:38 PMCR- 2026/08/07 CRDT- 2026/08/07 20:03 PHST- 2026/08/08 00:38 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 20:03 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 10.1177_17455057261476900 [pii] AID - 10.1177/17455057261476900 [doi] PST - ppublish SO - Womens Health (Lond). 2026 Jan-Dec;22:17455057261476900. doi: 10.1177/17455057261476900. Epub 2026 Aug 7. PMID- 42566620 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 32 DP - 2026 Aug 7 TI - Development and validation of a nomogram prediction model for mild pulmonary arterial hypertension risk in children with left-to-right shunt congenital heart disease. PG - e50136 LID - 10.1097/MD.0000000000050136 [doi] LID - e50136 AB - Mild pulmonary arterial hypertension (PAH) represents an early and potentially reversible complication stage in children with congenital structural heart disease (CHD). Early identification of high-risk children is crucial for improving prognosis. This study aimed to develop and validate a nomogram model for predicting the risk of mild PAH in children with left-to-right shunt CHD. This single-center retrospective study enrolled 340 children diagnosed with CHD who underwent cardiac catheterization at the Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, between January 2005 and April 2022. Patients were divided into a training set (n = 237) and an internal validation set (n = 103) at a 7:3 ratio using stratified random sampling. In the training set, predictors were selected from 35 candidate variables using least absolute shrinkage and selection operator regression combined with 10-fold cross-validation, and the final prediction model was constructed using multivariate logistic regression. Model performance was comprehensively evaluated through Bootstrap internal validation (1000 resampling iterations) and on the independent validation set, including discrimination (area under the curve [AUC]), calibration (calibration curve), and clinical utility (decision curve analysis). The model ultimately identified 5 independent predictive factors: loud P2, decreased exercise tolerance, defect size, left ventricular systolic diameter Z SCORE, and age. The nomogram constructed based on these factors achieved a Bootstrap-corrected AUC of 0.871 (95% confidence interval = 0.824-0.919) in the training set and an AUC of 0.861 (95% confidence interval = 0.769-0.938) in the independent validation set. The calibration curve indicated high consistency between predicted probabilities and actual observed values. Decision curve analysis demonstrated that the model provided clinical net benefit across a wide range of threshold probabilities. This study successfully developed and validated a well-performing nomogram model for predicting the risk of mild PAH in children with left-to-right shunt CHD. This model integrates easily accessible clinical, imaging, and demographic indicators, facilitating the early identification of high-risk children and providing a practical tool for personalized intervention and clinical decision-making. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Qin, Suyuan AU - Qin S AUID- ORCID: 0009-0000-8036-5365 AD - Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Difficult and Critical Illness Center and the Pediatric Clinical Medical Research Center of Guangxi, Nanning, Guangxi, China. FAU - Shang, Lifeng AU - Shang L FAU - Su, Danyan AU - Su D FAU - Ye, Bingbing AU - Ye B FAU - Huang, Yuqin AU - Huang Y FAU - Huang, Yanyun AU - Huang Y FAU - Pang, Yusheng AU - Pang Y LA - eng PT - Journal Article PT - Validation Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Nomograms MH - *Heart Defects, Congenital/complications MH - Retrospective Studies MH - Female MH - Child MH - Male MH - Child, Preschool MH - *Pulmonary Arterial Hypertension/etiology/diagnosis MH - Cardiac Catheterization MH - Risk Factors MH - Infant MH - Prediction Algorithms MH - *Hypertension, Pulmonary MH - Risk Assessment MH - Prognosis PMC - PMC13456828 OTO - NOTNLM OT - congenital heart disease OT - mild pulmonary arterial hypertension OT - nomogram OT - prediction model OT - risk factors COIS- The authors have no conflicts of interest to declare. EDAT- 2026/08/07 18:36 MHDA- 2026/08/07 18:37 PMCR- 2026/08/07 CRDT- 2026/08/07 14:13 PHST- 2026/01/30 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/07 18:37 [medline] PHST- 2026/08/07 18:36 [pubmed] PHST- 2026/08/07 14:13 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 00005792-202608070-00066 [pii] AID - MD-D-26-00941 [pii] AID - 10.1097/MD.0000000000050136 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 7;105(32):e50136. doi: 10.1097/MD.0000000000050136. PMID- 42566616 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 32 DP - 2026 Aug 7 TI - Mid-upper arm circumference and diabetes/prediabetes in children and adolescents: A cross-sectional study using NHANES data. PG - e50083 LID - 10.1097/MD.0000000000050083 [doi] LID - e50083 AB - Mid-upper arm circumference (MUAC) is a simple anthropometric measure proposed as a marker of adiposity and cardiometabolic risk, but its relationship with diabetes and prediabetes in children and adolescents has not been fully characterized. This study assessed the association between MUAC and glycemic status in a nationally representative pediatric sample. We performed a cross-sectional analysis of pooled data from the 1999 to 2018 NHANES cycles, including 27,543 children and adolescents (age 6-19 years), of whom 2165 were classified as having diabetes or prediabetes by standard laboratory and self-report criteria. MUAC was measured at the midpoint of the right upper arm. Survey-weighted logistic regression models evaluated MUAC as both a continuous and categorical (quartiles) predictor of diabetes/prediabetes, adjusting for age, sex, race, education, poverty‑income ratio, body mass index, elevated blood pressure, and dyslipidemia. Restricted cubic spline analysis examined nonlinearity; subgroup analyses tested robustness. Higher MUAC was independently associated with higher odds of diabetes/prediabetes: per 1‑cm increase odds ratio: 1.04 (95% confidence interval [CI]: 1.01-1.08; P = .020). Versus Q1, adjusted odds ratios were Q2 2.57 (95% CI: 1.81-3.67), Q3 2.40 (95% CI: 1.60-3.61), Q4 2.49 (95% CI: 1.57-3.97) (all P < .001). Restricted cubic spline revealed a significant non‑linear association (P‑nonlinearity <.001) with an inflection near MUAC approximately 25.6 cm, above which odds increased more steeply. Subgroup analyses indicated stronger associations in females and in children <14 years. Associations remained consistent across the analyses. In this large, nationally representative sample of children and adolescents, elevated MUAC was independently associated with higher odds of diabetes and prediabetes, with evidence of a nonlinear dose-response and a threshold near 25.6 cm. Prospective studies are needed to validate cutoffs and explore the potential role of MUAC as a risk marker for dysglycemia. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Zhu, Li AU - Zhu L AUID- ORCID: 0009-0003-0595-3038 AD - Department of Pediatrics, Chengde Central Hospital, Chengde, Hebei, China. FAU - Li, He AU - Li H FAU - Li, Tao AU - Li T LA - eng GR - 202406A008/S&T Program of Chengde/ PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - *Prediabetic State/epidemiology/diagnosis MH - Child MH - *Arm/anatomy & histology MH - Male MH - Nutrition Surveys MH - *Diabetes Mellitus/epidemiology/diagnosis MH - Young Adult MH - Adiposity MH - Anthropometry/methods MH - Body Mass Index MH - United States/epidemiology PMC - PMC13456841 OTO - NOTNLM OT - children and adolescents OT - cross-sectional analysis OT - diabetes/prediabetes OT - mid‑upper arm circumference COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/08/07 18:36 MHDA- 2026/08/07 18:37 PMCR- 2026/08/07 CRDT- 2026/08/07 14:13 PHST- 2025/12/19 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/07 18:37 [medline] PHST- 2026/08/07 18:36 [pubmed] PHST- 2026/08/07 14:13 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 00005792-202608070-00062 [pii] AID - MD-D-25-18375 [pii] AID - 10.1097/MD.0000000000050083 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 7;105(32):e50083. doi: 10.1097/MD.0000000000050083. PMID- 42566600 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260828 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 32 DP - 2026 Aug 7 TI - Aerobic exercise and sleep-related outcomes in children and adolescents: A systematic review and meta-analysis of randomized controlled trials. PG - e50049 LID - 10.1097/MD.0000000000050049 [doi] LID - e50049 AB - BACKGROUND: Sleep problems are increasingly prevalent among children and adolescents, contributing to impaired daytime functioning, reduced academic performance, and long-term health risks. Aerobic exercise has been proposed as a promising behavioral strategy to promote sleep health in youth; yet, evidence from randomized controlled trials (RCTs) remains variable. This systematic review and meta-analysis synthesized randomized controlled trials to estimate the effects of aerobic exercise on sleep-related outcomes in children and adolescents and to explore potential sources of heterogeneity. METHODS: Several major English and Chinese databases, including PubMed, Web of Science, EBSCO, Cochrane Library, Scopus, and CNKI, were systematically searched up to August 2025. Fourteen studies were included. Effect sizes were expressed as standardized mean differences (SMDs) and oriented so that positive values indicated improvement in sleep-related outcomes. A random-effects meta-analysis using restricted maximum likelihood estimation and the Hartung-Knapp adjustment was performed, with 95% prediction intervals calculated. Prespecified exploratory subgroup analyses examined intervention duration, measurement modality, and age group, with formal tests for subgroup differences where feasible. RESULTS: Aerobic exercise was associated with improved sleep-related outcomes (SMD = 0.91, 95% CI: 0.40-1.43), with considerable heterogeneity (I2 = 91.5%) and a 95% prediction interval of -0.98 to 2.80. Exploratory subgroup estimates varied by intervention duration, measurement modality, and age; however, tests for subgroup differences were not statistically significant (P = .291, P = .868, and P = .873, respectively). These findings should be interpreted cautiously because several subgroups contained few studies. CONCLUSIONS: Aerobic exercise may improve sleep-related outcomes in children and adolescents. However, the magnitude and consistency of the benefit remain uncertain because of considerable heterogeneity, a prediction interval crossing the null, heterogeneous outcome definitions, and the limited number of studies in several subgroups. Further well-designed RCTs using standardized sleep outcomes and objective measures, where feasible, are needed. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Ma, Qi-Shuai AU - Ma QS AD - Graduate School of Physical Education, Myongji University, Yongin-si, Gyeonggi-do, Republic of Korea. FAU - Chun, Buong-O AU - Chun BO AD - Graduate School of Physical Education, Myongji University, Yongin-si, Gyeonggi-do, Republic of Korea. FAU - Zhang, Rong AU - Zhang R AUID- ORCID: 0009-0000-5770-7881 AD - School of Sports and Health, Sichuan Technology and Business University, Chengdu, Sichuan, China. LA - eng GR - 2025DNYZC013/A Comparative Study on Physical Education Governance Policies in Universities in Southeast Asia: From the Perspective of Promoting Youth Mental Health/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Child MH - Adolescent MH - *Exercise/physiology MH - Randomized Controlled Trials as Topic MH - *Sleep/physiology MH - *Sleep Wake Disorders/therapy/prevention & control PMC - PMC13456893 OTO - NOTNLM OT - aerobic exercise OT - children and adolescents OT - meta-analysis OT - physical activity OT - randomized controlled trials OT - sleep-related outcomes OT - subgroup analysis COIS- The authors have no conflicts of interests to declare. EDAT- 2026/08/07 18:36 MHDA- 2026/08/07 18:37 PMCR- 2026/08/07 CRDT- 2026/08/07 14:12 PHST- 2026/03/10 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/07 18:37 [medline] PHST- 2026/08/07 18:36 [pubmed] PHST- 2026/08/07 14:12 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 00005792-202608070-00046 [pii] AID - MD-D-26-03812 [pii] AID - 10.1097/MD.0000000000050049 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 7;105(32):e50049. doi: 10.1097/MD.0000000000050049. PMID- 42566564 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 32 DP - 2026 Aug 7 TI - Assessing the association of healthy lifestyle indicators (life's simple 7) with bacterial vaginosis in reproductive-age women: A cross-sectional analysis of a nationwide survey. PG - e50069 LID - 10.1097/MD.0000000000050069 [doi] LID - e50069 AB - Bacterial vaginosis (BV) is a prevalent vaginal infection in reproductive-age women, associated with various behavioral and metabolic factors. Life's simple 7 (LS7), a cardiovascular health metric from the American Heart Association, includes smoking, physical activity, diet, body mass index, blood pressure, blood lipids, and blood glucose. This study aimed to explore the link between LS7 scores and BV, offering a perspective on comprehensive risk assessment. This cross-sectional study used data from the National Health and Nutrition Examination Survey 2001-2004, including 1203 women aged 18 to 49 years (382 BV, 821 controls). Accounting for National Health and Nutrition Examination Survey' complex design, we applied fasting weight (WTSAF2YR), strata (SDMVSTRA), and primary sampling unit (SDMVPSU). Weighted logistic regression models (Crude, Model 1, and Model 2) examined the LS7-BV association. Model 1 adjusted for age, race, poverty income ratio, marital status, and education; Model 2 further adjusted for white blood cell, lymphocyte, monocyte counts, and globulin. LS7 was analyzed categorically (<8.5 vs >/= 8.5), with the cutoff determined by receiver operating characteristic curve. We also performed restricted cubic spline analysis, Extreme Gradient Boosting, and subgroup analyses. Weighted baseline analysis showed that the LS7 score in the BV group (8.31 +/- 2.01) was significantly lower than that in the normal group (8.93 +/- 2.02, P < .001). Weighted logistic regression revealed that each 1-unit increase in LS7 was associated with lower BV odds in the Crude Model (odds ratio [OR] = 0.86, 95% confidence interval [CI]: 0.80-0.92, P < .001) and remained significant in Model 2 (OR = 0.90, 95% CI: 0.82-0.98, P = .013). In categorical analysis, LS7 >/= 8.5 was associated with lower BV odds than < 8.5 (Crude OR = 0.60, 95% CI: 0.43-0.85, P = .005). Restricted cubic spline analysis showed a significant inverse dose-response relationship (P for overall = .001). Subgroup and sensitivity analyses confirmed consistent inverse associations and robustness. Higher LS7 scores were associated with lower odds of BV. Due to the cross-sectional design, these findings are associational and cannot establish causality. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Feng, Yang AU - Feng Y AUID- ORCID: 0009-0007-2069-4985 AD - Department of Gynecology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhang, Xiaoqian AU - Zhang X AUID- ORCID: 0009-0002-2763-3126 LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Female MH - Humans MH - Cross-Sectional Studies MH - *Vaginosis, Bacterial/epidemiology MH - Adult MH - Adolescent MH - Middle Aged MH - Nutrition Surveys MH - Young Adult MH - *Healthy Lifestyle MH - Body Mass Index MH - United States/epidemiology MH - Risk Assessment MH - Risk Factors MH - Exercise MH - Blood Pressure MH - Diet PMC - PMC13456739 OTO - NOTNLM OT - NHANES OT - bacterial vaginosis (BV) OT - lifestyle factors OT - life's simple 7 (LS7) COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/08/07 18:36 MHDA- 2026/08/07 18:37 PMCR- 2026/08/07 CRDT- 2026/08/07 14:12 PHST- 2025/11/26 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/07 18:37 [medline] PHST- 2026/08/07 18:36 [pubmed] PHST- 2026/08/07 14:12 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 00005792-202608070-00010 [pii] AID - MD-D-25-16838 [pii] AID - 10.1097/MD.0000000000050069 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 7;105(32):e50069. doi: 10.1097/MD.0000000000050069. PMID- 42565990 OWN - NLM STAT- Publisher LR - 20260807 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) DP - 2026 Aug 7 TI - Estimating Exercise Intensity Using Heart Rate Methods in Children and Young Adults with Pulmonary Hypertension. LID - 10.1007/s00246-026-04411-z [doi] AB - Standard methods for prescribing exercise intensity in exercise therapy define moderate and vigorous exercise using a percentage of peak heart rate (HR). However, these approaches may be inappropriate for pediatric patients with pulmonary hypertension (PH) due to impaired vasodilatory function, chronotropic incompetence, and because the methods were developed based on adult data. This study aimed to evaluate the accuracy of recommended exercise prescription methods in children and young adults with PH. This retrospective study included patients aged 6-25 years with PH. Accuracy was assessed by comparing HR values for moderate and vigorous exercise zones, defined by traditional methods against a gold standard (GS) derived from cardiac or pulmonary exercise testing using the ventilatory threshold and respiratory compensation threshold. Independent t-tests were used to assess differences between methods, and Bland-Altman plots were used to determine limits of agreement relative to the GS. Data from 134 patients (mean age 17 +/- 4 years) were analyzed. For moderate intensity, HR values generated by all three traditional techniques differed significantly from the GS (all p < 0.001). For vigorous intensity, zones based on percentage of peak VO(2) and percentage of peak HR were significantly different from the GS (p < 0.001), whereas zones based on percentage of HR reserve were not (p = 0.558). Bland-Altman analysis showed poor agreement overall, with most cases falling outside acceptable limits of difference (approximately 50-80% of cases). Recommended exercise prescription methods did not accurately define exercise intensity zones in pediatric and young adult patients with PH. Population-specific approaches may improve exercise prescription accuracy in this group. CI - (c) 2026. The Author(s). FAU - Kwan, Li Ting AU - Kwan LT AD - Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Del Mundo, Ruskin Jake S AU - Del Mundo RJS AD - Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. FAU - McCown, Mary E AU - McCown ME AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Fremed, Michael A AU - Fremed MA AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Krishnan, Usha S AU - Krishnan US AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Liberman, Leonardo AU - Liberman L AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Asiedu, Quinten D AU - Asiedu QD AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Layton, Aimee M AU - Layton AM AUID- ORCID: 0000-0002-5452-2811 AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. aml2135@cumc.columbia.edu. AD - Children's Hospital of New York, 7th floor, room 711 3959 Broadway, New York, NY, 10032, USA. aml2135@cumc.columbia.edu. LA - eng PT - Journal Article DEP - 20260807 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM OTO - NOTNLM OT - Exercise OT - Exercise prescription OT - Pediatric OT - Pulmonary hypertension OT - Rehabilitation COIS- Declarations. Competing Interests: The authors declare no competing interests. EDAT- 2026/08/07 12:39 MHDA- 2026/08/07 12:39 CRDT- 2026/08/07 11:13 PHST- 2026/03/24 00:00 [received] PHST- 2026/07/25 00:00 [accepted] PHST- 2026/08/07 12:39 [medline] PHST- 2026/08/07 12:39 [pubmed] PHST- 2026/08/07 11:13 [entrez] AID - 10.1007/s00246-026-04411-z [pii] AID - 10.1007/s00246-026-04411-z [doi] PST - aheadofprint SO - Pediatr Cardiol. 2026 Aug 7. doi: 10.1007/s00246-026-04411-z. PMID- 42565127 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260807 LR - 20260813 IS - 0971-9261 (Print) IS - 1998-3891 (Electronic) IS - 0971-9261 (Linking) VI - 31 IP - 4 DP - 2026 Jul-Aug TI - Single-incision Scrotal Orchidopexy in Children: A Clinical Series. PG - 638-642 LID - 10.4103/jiaps.jiaps_21_26 [doi] AB - OBJECTIVE: To evaluate the feasibility, success rate, and outcomes of single-incision scrotal orchiopexy (SISO) for palpable undescended testes using a novel "touch sign" for patient selection. No comparison groups were included. METHODS: A retrospective review of 162 patients (aged 7 months-14 years) treated between 2019 and 2024 was performed. Palpable cases underwent preoperative "touch sign" assessment (balloting the testis from the inguinal canal to the scrotum), followed by transverse scrotal incision, tunica vaginalis mobilization, and dartos pouch placement. RESULTS: Of the 162 patients assessed, 116 underwent SISO (112 successful; 4 conversions due to obesity or tunica vaginalis issues). Follow-up (1 month-5 years) showed no testicular atrophy, and one patient developed a clinical inguinal hernia after more than 3 years of SISO. SISO offers superior cosmesis and shorter operative time/hospital stay than the traditional method. CONCLUSION: SISO is a safe and effective procedure for low-lying palpable testes, with the "touch sign" improving patient selection and minimizing conversions. The first author has described this novel maneuver- the "touch sign" during the clinical examination. CI - Copyright: (c) 2026 Journal of Indian Association of Pediatric Surgeons. FAU - Miglani, Harparkash Singh AU - Miglani HS AD - Child Surgery Centre, Miglani Hospital, Amritsar, Punjab, India. FAU - Sethi, Bijaya Kumar AU - Sethi BK AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India. FAU - Hanspal, Era AU - Hanspal E AD - Resident Doctor Foundation Year 2, Department of General Practice NHS Grampian, Elgin, United Kingdom. LA - eng PT - Journal Article DEP - 20260702 PL - India TA - J Indian Assoc Pediatr Surg JT - Journal of Indian Association of Pediatric Surgeons JID - 101179870 PMC - PMC13446958 OTO - NOTNLM OT - Orchiopexy OT - palpable undescended testes OT - single-incision scrotal orchiopexy OT - testicular mobilization OT - touch sign COIS- There are no conflicts of interest. EDAT- 2026/08/07 12:39 MHDA- 2026/08/07 12:40 PMCR- 2026/07/01 CRDT- 2026/08/07 06:27 PHST- 2026/01/09 00:00 [received] PHST- 2026/02/20 00:00 [revised] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/08/07 12:40 [medline] PHST- 2026/08/07 12:39 [pubmed] PHST- 2026/08/07 06:27 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - JIAPS-31-638 [pii] AID - 10.4103/jiaps.jiaps_21_26 [doi] PST - ppublish SO - J Indian Assoc Pediatr Surg. 2026 Jul-Aug;31(4):638-642. doi: 10.4103/jiaps.jiaps_21_26. Epub 2026 Jul 2. PMID- 42564828 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260807 LR - 20260813 IS - 2574-2531 (Electronic) IS - 2574-2531 (Linking) VI - 9 IP - 4 DP - 2026 Aug TI - Identification of obesity risk factors in 3-12-year-old children and adolescents with prior respiratory tract infections via interpretable machine and deep learning models. PG - ooag061 LID - 10.1093/jamiaopen/ooag061 [doi] LID - ooag061 AB - BACKGROUNDS AND OBJECTIVES: Childhood obesity and respiratory tract infections (RTIs) are 2 major global public health issues that frequently co-occur and are closely interrelated. Early detection of children with prior RTIs who are at high obesity risk is crucial for targeted interventions. This study integrates interpretable machine learning (ML) models and a deep learning network to develop an obesity risk prediction model in a large pediatric cohort. METHODS: Cross-sectional data from 6509 children and adolescents aged 3-12 years with prior RTIs in Beijing and Tangshan were fed to 12 ML models to predict childhood obesity (versus children with normal weight). Bayesian optimization was applied to fine-tune model hyperparameters. Prediction performance was assessed using 8 metrics. Key predictive features were identified by SHapley Additive exPlanations (SHAP). The validity of the optimal ML model was verified by the sequential neural network model. RESULTS: Of 12 ML models, LightGBM achieved the optimal performance (accuracy: 0.8844, area under the curve [AUC]: 0.9491). SHAP analysis identified 20 key predictors, including child age, paternal body mass index (BMI), maternal BMI, birth length, birthweight, gestational age, eating speed, complementary feeding initiation age, screen time, breastfeeding duration, bedtime, maternal age, nighttime sleep, outdoor activity, dental caries, sedentary time, food allergies, family history of diabetes, and sex. The deep learning sequence network model further validated the predictive value of these features (accuracy: 0.8023, AUC: 0.8117), and the SHAP-driven feature importance rankings were in close line with LightGBM. CONCLUSIONS: Our LightGBM-based model enables effective prediction of obesity risk in children aged 3-12 years with prior RTIs, and the key features identified can inform early screening and facilitate personalized interventions. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the American Medical Informatics Association. FAU - Wang, Xiao-Qian AU - Wang XQ AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. FAU - Zheng, Fang-Jie-Yi AU - Zheng FJ AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Wang, Qiong AU - Wang Q AD - Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Li, Che AU - Li C AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Zhang, Wen-Qian AU - Zhang WQ AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Zhang, Zhi-Xin AU - Zhang ZX AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China. AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Niu, Wen-Quan AU - Niu WQ AUID- ORCID: 0000-0003-1715-3372 AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. LA - eng SI - Dryad/10.5061/dryad.gf1vhhn44 PT - Journal Article DEP - 20260806 PL - United States TA - JAMIA Open JT - JAMIA open JID - 101730643 PMC - PMC13445979 OTO - NOTNLM OT - Childhood obesity OT - SHapley Additive exPlanations OT - deep learning OT - machine learning OT - respiratory tract infection COIS- The authors declare that there is no conflict of interest regarding the publication of this article. EDAT- 2026/08/07 12:39 MHDA- 2026/08/07 12:40 PMCR- 2026/08/06 CRDT- 2026/08/07 06:08 PHST- 2026/01/05 00:00 [received] PHST- 2026/03/16 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/08/07 12:40 [medline] PHST- 2026/08/07 12:39 [pubmed] PHST- 2026/08/07 06:08 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - ooag061 [pii] AID - 10.1093/jamiaopen/ooag061 [doi] PST - epublish SO - JAMIA Open. 2026 Aug 6;9(4):ooag061. doi: 10.1093/jamiaopen/ooag061. eCollection 2026 Aug. PMID- 42564584 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1729-0503 (Electronic) IS - 1680-6905 (Print) IS - 1680-6905 (Linking) VI - 26 IP - 2 DP - 2026 Jun TI - Diagnostic relevance of osteocalcin and bone alkaline phosphatase as markers of bone turnover in Sickle Cell Anaemia: A Zaria study. PG - 59-68 LID - 10.4314/ahs.v26i2.8 [doi] AB - BACKGROUND: Sickle cell anaemia (SCA) significantly contributes to skeletal morbidity in Nigeria, with bone complications like pain crises and avascular necrosis prevalent. Osteocalcin (OC) and bone-specific alkaline phosphatase (BALP) are potential markers of bone formation, yet their diagnostic utility in SCA is underexplored in African populations. OBJECTIVE: To assess serum OC and BALP levels in Nigerian SCA patients during bone pain crises (BPC), steady state, and in healthy controls, evaluating their diagnostic relevance for bone turnover. METHODS: This cross-sectional study at Ahmadu Bello University Teaching Hospital, Zaria, enrolled 180 adults (60 SCA in BPC, 60 steady state, 60 HbAA controls). Serum OC and BALP were measured via ELISA. Data were analyzed using Kruskal-Wallis tests, Spearman's correlation, and ROC curves (p/=2 years. Secondary outcomes included recurrent pancreatitis within 2 years after ERCP, nutritional evolution, and pancreatic function. RESULTS: High rates of nutritional abnormalities were observed, including vitamin D deficiency (61.2%), undernutrition (18%), and overweight/obesity (5.2% & 5.2%). ERCP technical success was 99.17%. In this chronic pancreatitis-only cohort, PEP occurred after 111 of 360 procedures (30.8%) and was more frequent in preschool-aged than school-aged children (35.13% vs. 27.8%, P = 0.023). School-aged children showed a higher pre-discharge pain relief rate and significant VAS score reduction, whereas preschool-aged children had higher PEP rates and less statistically evident VAS score improvement. BMI showed an increasing trend mainly in school-aged children, with no significant change in preschool-aged children. CONCLUSIONS: ERCP appears feasible in pediatric CP, with high technical success and predominantly mild complications. Age was associated with differences in pain relief and PEP risk. Nutritional findings should be interpreted cautiously as a limited longitudinal signal rather than definitive improvement. IMPACT: Patient age was associated with differences in ERCP-related outcomes in pediatric chronic pancreatitis. School-aged children showed a higher pre-discharge pain relief rate, whereas preschool-aged children showed higher PEP rates and less statistically evident VAS score improvement, suggesting the need for careful age-specific risk assessment. To our knowledge, this is one of the largest age-stratified studies evaluating ERCP-related clinical and nutritional outcomes in pediatric chronic pancreatitis. These findings may support age-specific risk assessment, closer monitoring of younger children, and more individualized nutritional follow-up after ERCP. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Zhu, Yu AU - Zhu Y AD - Department of Gastroenterology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Zhang, Tianao AU - Zhang T AD - Department of Gastroenterology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Ding, Sheng AU - Ding S AD - Department of Gastroenterology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Gong, Biao AU - Gong B AD - Digestive Endoscopy Center, Department of Gastroenterology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Hong, Li AU - Hong L AD - Department of Clinical Nutrition, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. hongli@scmc.com.cn. FAU - Deng, Zhaohui AU - Deng Z AD - Department of Gastroenterology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. dzhrj@163.com. LA - eng PT - Journal Article DEP - 20260806 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: The requirement for informed consent was waived due to the retrospective nature of the study. EDAT- 2026/08/07 06:35 MHDA- 2026/08/07 06:35 CRDT- 2026/08/07 00:06 PHST- 2025/09/30 00:00 [received] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/06/19 00:00 [revised] PHST- 2026/08/07 06:35 [medline] PHST- 2026/08/07 06:35 [pubmed] PHST- 2026/08/07 00:06 [entrez] AID - 10.1038/s41390-026-05351-3 [pii] AID - 10.1038/s41390-026-05351-3 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Aug 6. doi: 10.1038/s41390-026-05351-3. PMID- 42562545 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260806 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 241 DP - 2026 Oct 1 TI - LC-MS/MS outperforms ELISA and UPLC-PDA for targeted quantification of 25(OH)D(2) and 25(OH)D(3) in human milk: A practical analytical strategy. PG - 119787 LID - S0963-9969(26)01470-5 [pii] LID - 10.1016/j.foodres.2026.119787 [doi] AB - Accurate analysis of vitamin D in human milk is essential for infant nutrition but remains analytically challenging due to low levels and a complex matrix. This study evaluates a practical multi-method strategy using LC-MS/MS, ELISA, and UPLC-PDA for vitamin D analysis in human milk. LC-MS/MS precisely quantified 25(OH)D(2) and 25(OH)D(3) with assay LOQ of 0.045 ng/mL and 0.100 ng/mL, respectively. ELISA showed a 11.58 ng/mL positive bias of vitamin D which limits use for accurate quantification. UPLC-PDA profiled vitamins A and E effectively but lacked sensitivity for vitamin D. Longitudinally, LC-MS/MS results show 25(OH)D(3) and total 25(OH)D concentrations remained relatively stable, with medians ranging from 0.141 to 0.281 ng/mL and 0.263 to 0.315 ng/mL, respectively, across the study period, while 25(OH)D(2) peaked at 8 weeks before declining. This study establishes LC-MS/MS as the preferred analytical strategy for quantifying 25(OH)D(2) and 25(OH)D(3) in human milk, providing critical data to assess infant nutritional intake and guide clinical interventions. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Zhao, Yuanyuan AU - Zhao Y AD - State Key Lab of Food Science and Resources, Jiangnan University, Wuxi 214122, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Lu, Yongmao AU - Lu Y AD - State Key Lab of Food Science and Resources, Jiangnan University, Wuxi 214122, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Yang, Tian AU - Yang T AD - Analysis and Testing Center, Jiangnan University, Wuxi 214122, China. FAU - Hu, Shaohua AU - Hu S AD - State Key Lab of Food Science and Resources, Jiangnan University, Wuxi 214122, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Yan, Yuanyuan AU - Yan Y AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. FAU - Wang, Xingguo AU - Wang X AD - State Key Lab of Food Science and Resources, Jiangnan University, Wuxi 214122, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Wei, Wei AU - Wei W AD - State Key Lab of Food Science and Resources, Jiangnan University, Wuxi 214122, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: weiw@jiangnan.edu.cn. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260615 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 RN - P6YZ13C99Q (Calcifediol) RN - 21343-40-8 (25-Hydroxyvitamin D 2) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - *Tandem Mass Spectrometry/methods MH - *Calcifediol/analysis MH - Enzyme-Linked Immunosorbent Assay/methods MH - *Liquid Chromatography-Mass Spectrometry/methods MH - *25-Hydroxyvitamin D 2/analysis MH - Reproducibility of Results MH - Chromatography, High Pressure Liquid/methods MH - Female MH - Chromatography, Liquid/methods OTO - NOTNLM OT - Bioactive lipids OT - Clinical screening OT - ELISA OT - Human milk OT - LC-MS/MS OT - Nutritional epidemiology OT - Vitamin D COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/07 00:35 MHDA- 2026/08/07 00:36 CRDT- 2026/08/06 20:54 PHST- 2026/04/24 00:00 [received] PHST- 2026/06/13 00:00 [revised] PHST- 2026/06/14 00:00 [accepted] PHST- 2026/08/07 00:36 [medline] PHST- 2026/08/07 00:35 [pubmed] PHST- 2026/08/06 20:54 [entrez] AID - S0963-9969(26)01470-5 [pii] AID - 10.1016/j.foodres.2026.119787 [doi] PST - ppublish SO - Food Res Int. 2026 Oct 1;241:119787. doi: 10.1016/j.foodres.2026.119787. Epub 2026 Jun 15. PMID- 42562460 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260806 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 241 DP - 2026 Oct 1 TI - Lactation-stage profiles of rRNA-derived small RNAs in human milk exosome-enriched fractions: Compositional features and relevance to infant nutrition. PG - 119640 LID - S0963-9969(26)01323-2 [pii] LID - 10.1016/j.foodres.2026.119640 [doi] AB - Human milk exosome-enriched fractions contain exosome-like vesicles and bioactive molecules, yet the compositional features of rRNA-derived small RNAs (rsRNAs) and their variation across lactation stages remain unclear. In this study, exosome-enriched fractions were isolated and characterized from human colostrum (HC) and mature milk (HM) collected from healthy lactating mothers, and small RNA sequencing was used to systematically profile the rsRNA landscape, differential patterns, and positional origin distribution in these fractions. The results showed that human milk exosome-enriched fractions contained diverse rsRNAs, mainly derived from 18S, 28S, 5.8S, and 5S rRNAs. Compared with HM, rsRNAs in HC-derived exosome-enriched fractions exhibited marked differences in compositional proportion, length distribution, and abundance, indicating lactation-stage-associated variation. Coverage analysis further showed that most rsRNAs were not evenly distributed across full-length precursor rRNAs but were concentrated in specific regions, which is consistent with non-random enrichment patterns. Target prediction and functional enrichment analyses of representative differential rsRNAs suggested possible associations with pathways related to immune-related signaling, epithelial barrier function, and cell growth; however, these results should be interpreted as hypothesis-generating and require further experimental validation. Collectively, this study reveals the compositional characteristics and lactation-stage-associated profiles of rsRNAs in human milk exosome-enriched fractions, expands current understanding of milk-borne bioactive small RNA systems, and provides candidate molecular information for future studies on stage-specific bioactive components relevant to infant nutrition. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Chen, Xinping AU - Chen X AD - College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China. FAU - Liu, Xiaoyu AU - Liu X AD - Department of Obstetrics and Gynaecology, General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenhe District, Shenyang 110016, China. FAU - Meng, Ying AU - Meng Y AD - College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China. FAU - Hu, Yutong AU - Hu Y AD - College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China. FAU - Guan, Ze AU - Guan Z AD - College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China. FAU - Yue, Xiqing AU - Yue X AD - College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China. Electronic address: yxqsyau@126.com. FAU - Yang, Mei AU - Yang M AD - College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China. Electronic address: 18624061478@163.com. LA - eng PT - Journal Article DEP - 20260612 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 RN - 0 (RNA, Ribosomal) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - *Exosomes/chemistry/metabolism/genetics MH - Female MH - *Lactation/genetics MH - *RNA, Ribosomal/genetics/analysis MH - *Infant Nutritional Physiological Phenomena MH - Colostrum/chemistry MH - Infant MH - Adult OTO - NOTNLM OT - Bioactive small RNAs OT - Exosome-enriched fractions OT - Human milk OT - Infant nutrition OT - Lactation stage OT - rRNA-derived small RNAs COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/07 00:35 MHDA- 2026/08/07 00:36 CRDT- 2026/08/06 20:53 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/08/07 00:36 [medline] PHST- 2026/08/07 00:35 [pubmed] PHST- 2026/08/06 20:53 [entrez] AID - S0963-9969(26)01323-2 [pii] AID - 10.1016/j.foodres.2026.119640 [doi] PST - ppublish SO - Food Res Int. 2026 Oct 1;241:119640. doi: 10.1016/j.foodres.2026.119640. Epub 2026 Jun 12. PMID- 42561615 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260924 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 149 IP - 1-2 DP - 2026 Sep-Oct TI - Sapropterin (BH4) challenge in phenylketonuria: Responder or non-responder? PG - 110226 LID - S1096-7192(26)00509-3 [pii] LID - 10.1016/j.ymgme.2026.110226 [doi] AB - Sapropterin dihydrochloride, the synthetic form of tetrahydrobiopterin (BH4), is an established pharmacological treatment for a subset of patients with phenylalanine hydroxylase (PAH) deficiency. Yet the clinically simple question of whether a patient is a "responder" or "non-responder" remains difficult to answer in a uniform way. Since the first description of BH4-responsive PAH deficiency, challenge protocols have varied substantially, ranging from short 4-8 h loading tests to 24-48 h protocols, 72 h to 7-day approaches, and treatment trials lasting several weeks or months. These protocols differ in dose, duration, sampling schedule, dietary conditions, baseline phenylalanine (Phe) concentration, use of Phe loading, and response definition. European, American, and Japanese guidance also differ in target ranges and in how responsiveness is confirmed. The widely used criterion of at least 30% reduction in blood Phe is practical for short biochemical testing, but it may be insufficient in patients who are already well controlled on diet, in slow responders, in infants or preschool children in whom BH4 bioavailability may be lower, and in patients whose main benefit is increased daily dietary Phe tolerance rather than further Phe reduction. Recent European guidance distinguishes potential sapropterin responsiveness from long-term responsiveness, defining the latter by increased natural protein intake and/or improved biochemical control within the recommended therapeutic target range. Japanese guidance adds an important Asian perspective by recommending BH4 administration tests for all hyperphenylalaninemia/phenylketonuria (PKU) cases rather than relying only on phenotype or blood Phe level, and recent Japanese data suggest that age and baseline Phe may influence blood biopterin peaks and the risk of false-negative tests. This narrative review summarizes the historical development, biological rationale, clinical evidence, geographical variation, genotype-specific considerations, and practical limitations of BH4/sapropterin responsiveness testing in PKU. We propose a pragmatic responder/non-responder framework based on three linked dimensions: blood Phe reduction, increase in daily dietary Phe tolerance, and maintenance of blood Phe within age-, pregnancy-, and guideline-specific therapeutic ranges. A responder is best defined as a patient who demonstrates either reproducible biochemical response or clinically meaningful therapeutic benefit, while a non-responder is a patient who demonstrates neither under adequate testing conditions. Evidence from extended Dutch testing further supports using 7-day protocols selectively when 48 h results are borderline or clinically discordant, while avoiding a simple 20% threshold because of false-positive risk. CI - Copyright (c) 2026 The Author. Published by Elsevier Inc. All rights reserved. FAU - Blau, Nenad AU - Blau N AD - Division of Metabolism, University Children's Hospital, Zurich, Switzerland. Electronic address: nenad.blau@kispi.uzh.ch. LA - eng PT - Journal Article PT - Review DEP - 20260804 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 RN - 0 (Biopterins) RN - EGX657432I (sapropterin) RN - 47E5O17Y3R (Phenylalanine) RN - EC 1.14.16.1 (Phenylalanine Hydroxylase) SB - IM MH - Humans MH - *Phenylketonurias/drug therapy/blood/genetics MH - *Biopterins/analogs & derivatives/therapeutic use/administration & dosage MH - Phenylalanine/blood MH - Phenylalanine Hydroxylase/genetics OTO - NOTNLM OT - Allelic phenotype value OT - BH4 responsiveness OT - Genotype OT - PAH deficiency OT - Phenylalanine tolerance OT - Phenylketonuria OT - Sapropterin OT - Tetrahydrobiopterin COIS- Declaration of competing interest The authors declare that they have no conflicts of interest related to this manuscript. EDAT- 2026/08/07 00:35 MHDA- 2026/09/24 23:52 CRDT- 2026/08/06 18:05 PHST- 2026/06/26 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/07/26 00:00 [accepted] PHST- 2026/09/24 23:52 [medline] PHST- 2026/08/07 00:35 [pubmed] PHST- 2026/08/06 18:05 [entrez] AID - S1096-7192(26)00509-3 [pii] AID - 10.1016/j.ymgme.2026.110226 [doi] PST - ppublish SO - Mol Genet Metab. 2026 Sep-Oct;149(1-2):110226. doi: 10.1016/j.ymgme.2026.110226. Epub 2026 Aug 4. PMID- 42561246 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1980-5497 (Electronic) IS - 1415-790X (Print) IS - 1415-790X (Linking) VI - 29 DP - 2026 TI - Age at menarche and blood pressure in late adolescence: the role of body adiposity in a Brazilian birth cohort. PG - e260038 LID - S1415-790X2026000101033 [pii] LID - 10.1590/1980-549720260038 [doi] LID - e260038 AB - OBJECTIVE: To investigate the association between age at menarche and blood pressure in adolescence, and to examine the role of body adiposity in this relationship. METHODS: This was a cross-sectional analysis nested within a population-based birth cohort conducted in Sao Luis, Maranhao, Brazil. The study included 885 female adolescents aged 18-19 years. Age at menarche was self-reported. Systolic and diastolic blood pressure were measured using a validated digital device, and body adiposity was assessed by air displacement plethysmography. Pearson correlation coefficients were estimated, and linear regression models were used to evaluate the association between age at menarche and blood pressure, with sequential adjustment for socioeconomic, behavioral, family, and perinatal factors, followed by additional adjustment for body adiposity. RESULTS: Age at menarche showed weak inverse correlations with systolic and diastolic blood pressure and a negative correlation with body adiposity. Body adiposity, in turn, was positively correlated with both systolic and diastolic blood pressure. In adjusted models, age at menarche remained significantly associated with blood pressure after controlling for socioeconomic, behavioral, family, and perinatal factors; however, these associations were attenuated and lost statistical significance after additional adjustment for body adiposity. CONCLUSION: The association between age at menarche and blood pressure in adolescence appears to be largely influenced by body adiposity, highlighting the importance of considering body composition when evaluating cardiovascular risk related to pubertal timing. FAU - Santos, Juliana Jansen AU - Santos JJ AUID- ORCID: 0009-0006-0924-9031 AD - Universidade Federal do Maranhao, Postgraduate Program in Nursing, Center for Biological and Health Sciences - Sao Luis (MA), Brazil. FAU - Lima, Janielle Ferreira de Brito AU - Lima JFB AUID- ORCID: 0000-0003-3027-2763 AD - Universidade Federal do Maranhao, Nursing Course Coordination, Center for Biological and Health Sciences - Sao Luis (MA), Brazil. FAU - Gomes, Maria Luziene de Sousa AU - Gomes MLS AUID- ORCID: 0000-0001-8583-0959 AD - Universidade Federal do Maranhao, Nursing Course Coordination, Center for Biological and Health Sciences - Sao Luis (MA), Brazil. FAU - Galvao, Kayo Elmano Costa da Ponte AU - Galvao KECDP AUID- ORCID: 0000-0003-4409-7222 AD - Universidade Federal do Maranhao, Postgraduate Program in Public Health, Center for Biological and Health Sciences - Sao Luis (MA), Brazil. FAU - Teixeira, Dannyel Rogger Almeida AU - Teixeira DRA AUID- ORCID: 0009-0003-8399-2868 AD - Universidade Federal do Maranhao, Postgraduate Program in Nursing, Center for Biological and Health Sciences - Sao Luis (MA), Brazil. FAU - Soares, Lua Beatriz Nascimento AU - Soares LBN AUID- ORCID: 0009-0009-8222-4430 AD - Universidade Federal do Maranhao, Nursing Course, Center for Biological and Health Sciences - Sao Luis (MA), Brazil. FAU - Correa, Rita da Graca Carvalhal Frazao AU - Correa RDGCF AUID- ORCID: 0000-0002-6451-5156 AD - Universidade Federal do Maranhao, Postgraduate Program in Nursing, Center for Biological and Health Sciences - Sao Luis (MA), Brazil. AD - Universidade Federal do Maranhao, University Hospital - Sao Luis (MA), Brazil. FAU - Batista, Rosangela Fernandes Lucena AU - Batista RFL AUID- ORCID: 0000-0002-1529-0165 AD - Universidade Federal do Maranhao, Postgraduate Program in Nursing, Center for Biological and Health Sciences - Sao Luis (MA), Brazil. LA - eng PT - Journal Article DEP - 20260731 PL - Brazil TA - Rev Bras Epidemiol JT - Revista brasileira de epidemiologia = Brazilian journal of epidemiology JID - 100954576 SB - IM MH - Humans MH - Female MH - *Adiposity/physiology MH - Brazil MH - Adolescent MH - *Menarche/physiology MH - *Blood Pressure/physiology MH - Cross-Sectional Studies MH - Age Factors MH - Young Adult MH - Birth Cohort PMC - PMC13427218 EDAT- 2026/08/06 18:35 MHDA- 2026/08/06 18:36 PMCR- 2026/07/31 CRDT- 2026/08/06 16:13 PHST- 2026/02/05 00:00 [received] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/08/06 18:36 [medline] PHST- 2026/08/06 18:35 [pubmed] PHST- 2026/08/06 16:13 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - S1415-790X2026000101033 [pii] AID - 10.1590/1980-549720260038 [doi] PST - epublish SO - Rev Bras Epidemiol. 2026 Jul 31;29:e260038. doi: 10.1590/1980-549720260038. eCollection 2026. PMID- 42560993 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Prevalence of sleep disturbances and their association with quality of life among the general population in Qassim, Saudi Arabia. PG - e0347188 LID - 10.1371/journal.pone.0347188 [doi] LID - e0347188 AB - To the best of our knowledge, no previous study has assessed the relationship between sleep disturbances and quality of life in the general population of Qassim, Saudi Arabia. Therefore, this cross-sectional study aimed to evaluate the relationship between sleep disorders and quality of life and to determine how common sleep disturbances are in Qassim, Saudi Arabia. To this end, participants were randomly selected from public areas. Study data were collected through a survey covering sociodemographic details, health information, the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality, and the Short Form-12 to measure health-related quality of life. The reliability of the scales was confirmed using Cronbach's alpha. The association between sleep quality and quality of life was analyzed using t-tests, Pearson's correlation, and hierarchical multiple regression. Of 1,241 participants, 64.5% were females, 94.8% were Saudi nationals, and 64.8% were students. The mean global PSQI score was 7.38 +/- 3.19, with 70.2% of participants reporting poor sleep quality. The mean physical and mental component scores were 42.6 +/- 7.98 and 38.9 +/- 8.03, respectively. Hierarchical multiple regression analyses indicated that after controlling for demographic characteristics, chronic disease, and body mass index, sleep-related variables significantly predicted both physical and mental health-related quality of life. The analysis showed that sleep-related factors had a substantially larger predictive contribution toward mental health (DeltaR2 = 5.7%) than toward physical health (DeltaR2 = 1.0%). In conclusion, this study revealed a high rate of poor sleep quality (70.2%) in Qassim, Saudi Arabia, with notable negative effects on mental health. Increasing awareness and integrating sleep assessments into public health initiatives are crucial for improving sleep quality. CI - Copyright: (c) 2026 Alsaud et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Alsaud, Jolan AU - Alsaud J AUID- ORCID: 0000-0003-0067-7479 AD - Qassim Health Cluster, Qassim, Saudi Arabia. FAU - Alkhalaf, Ghadi AU - Alkhalaf G AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Alsaleem, Rand AU - Alsaleem R AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Alqefari, Betool AU - Alqefari B AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Alfozan, Haifa AU - Alfozan H AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Alqaraawi, Lama AU - Alqaraawi L AUID- ORCID: 0009-0005-0067-9951 AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Wali, Siraj AU - Wali S AD - King Abdulaziz University, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260806 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - *Quality of Life MH - Female MH - *Sleep Wake Disorders/epidemiology MH - Male MH - Adult MH - Cross-Sectional Studies MH - Prevalence MH - Middle Aged MH - Sleep Quality MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent PMC - PMC13446683 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/06 18:35 MHDA- 2026/08/06 18:36 PMCR- 2026/08/06 CRDT- 2026/08/06 13:45 PHST- 2025/10/22 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/06 18:36 [medline] PHST- 2026/08/06 18:35 [pubmed] PHST- 2026/08/06 13:45 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - PONE-D-25-50621 [pii] AID - 10.1371/journal.pone.0347188 [doi] PST - epublish SO - PLoS One. 2026 Aug 6;21(8):e0347188. doi: 10.1371/journal.pone.0347188. eCollection 2026. PMID- 42560486 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260806 IS - 1464-5033 (Electronic) IS - 0301-4460 (Linking) VI - 53 IP - 1 DP - 2026 Dec TI - Association between body roundness index and asthma in children and adolescents: findings from NHANES 1999-2020. PG - 2705281 LID - 10.1080/03014460.2026.2705281 [doi] AB - BACKGROUND: Childhood and adolescent asthma remains a major public health concern, and obesity may contribute through mechanical and inflammatory pathways. The Body Roundness Index (BRI), derived from waist circumference and height, may better reflect central adiposity than general body-size measures. AIM: To investigate the association between BRI and asthma in children and adolescents. SUBJECTS AND METHODS: A total of 28,789 National Health and Nutrition Examination Survey (NHANES) 1999-2020 participants aged 6-20 years were included. Current asthma was identified using questionnaire data. BRI, calculated from waist circumference and height, was used as the primary exposure. Weighted multivariable logistic regression models were used to examine the association between BRI and current asthma, and restricted cubic spline (RCS) models were applied to assess potential nonlinear associations. Subgroup and sensitivity analyses were performed to assess the robustness of the findings. Weighted receiver operating characteristic (ROC) analyses were used to compare the predictive abilities of BRI and Body Mass Index (BMI) z-score in fully adjusted models. RESULTS: Higher BRI was associated with higher odds of current asthma (OR = 1.233, 95% CI:1.158-1.313, p < 0.001). RCS analysis suggested a nonlinear association between BRI and current asthma. In fully adjusted analyses, BRI and BMI z score showed comparable discriminative performance, with no significant difference in the area under the curve. CONCLUSIONS: Higher BRI was positively associated with current asthma among children and adolescents. Future prospective studies are warranted to clarify the temporal relationship and underlying biological mechanisms. FAU - Chen, Tingqiaonan AU - Chen T AD - Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China. FAU - Cai, Shujing AU - Cai S AD - Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China. FAU - Wang, Huiqin AU - Wang H AD - Department of Newborn, Jinhua Maternal and Child Health Care Hospital, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260806 PL - England TA - Ann Hum Biol JT - Annals of human biology JID - 0404024 SB - IM MH - Humans MH - *Asthma/epidemiology/etiology MH - Adolescent MH - Child MH - Nutrition Surveys MH - Female MH - Male MH - *Body Mass Index MH - *Waist Circumference MH - Young Adult MH - United States/epidemiology MH - *Body Height OTO - NOTNLM OT - Body Roundness Index OT - NHANES OT - asthma OT - children and adolescents OT - obesity EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 CRDT- 2026/08/06 11:12 PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 11:12 [entrez] AID - 10.1080/03014460.2026.2705281 [doi] PST - ppublish SO - Ann Hum Biol. 2026 Dec;53(1):2705281. doi: 10.1080/03014460.2026.2705281. Epub 2026 Aug 6. PMID- 42560161 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1460-2245 (Electronic) IS - 0957-4824 (Print) IS - 0957-4824 (Linking) VI - 41 IP - 4 DP - 2026 Jul 1 TI - The feasibility of the COMMUNICATE toolkit to support the communication of physical activity messages with adolescents in Irish schools. LID - 10.1093/heapro/daag110 [doi] LID - daag110 AB - The Active School Flag (ASF) is a peer-led whole-of-school physical activity (PA) programme in Irish secondary schools. This study assessed the feasibility of implementing the COMMUNICATE toolkit for ASF programme implementers (peer leaders and coordinating teachers). A pre-post, quasi-experimental, mixed-methods design was employed and guided by the Orsmond and Cohn feasibility objectives. Online surveys, semi-structured interviews, and focus groups were collected from six secondary schools (40% recruitment rate), 170 peer leaders, and three coordinating teachers. Survey data were analysed using descriptive statistics and independent and paired samples t-tests. Interview and focus group data were analysed using a combined inductive-deductive reflexive thematic analysis. Data were integrated during the writing-up stage. The toolkit was acceptable and appropriate; however, full implementation was hindered by time constraints within the busy school schedule and short implementation period. Methodological refinements regarding data collection timing and instrument validity and reliability were identified as necessary. Despite no differences between the intervention and control groups' communication skills or health knowledge at follow-up, the toolkit positively impacted peer leaders' personal development and knowledge and the PA and knowledge levels of their peers. While a real-world implementation design, led by programme implementers, may improve intervention sustainability and cost efficiency, implementation support and flexibility in delivery are essential. The COMMUNICATE toolkit was a valuable resource for whole-of-school programme implementers. Nevertheless, changes to the intervention and study procedures are required before proceeding to a definitive trial. Future research should consider an internal pilot within a definitive trial to ensure the changes are sufficient. CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Grady, Caera L AU - Grady CL AUID- ORCID: 0000-0002-9411-9066 AD - School of Sport and Human Performance, Faculty of Science and Health, Dublin City University, Dublin, Ireland. FAU - Murtagh, Elaine AU - Murtagh E AD - Physical Activity for Health Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. FAU - Ng, Kwok AU - Ng K AD - Physical Activity for Health Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. AD - Department of Teacher Education, Turku Institute for Advanced Studies, University of Turku, Turku, Finland. AD - Institute of Sports Science and Innovation, Lithuanian Sport University, Kaunas, Lithuania. FAU - Garcia Bengoechea, Enrique AU - Garcia Bengoechea E AD - Physical Activity for Health Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. FAU - Woods, Catherine B AU - Woods CB AD - Physical Activity for Health Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. LA - eng GR - Taighde Eireann/ GR - GOIPG/2022/78/Research Ireland Government of Ireland Postgraduate Scholarship/ PT - Journal Article PL - England TA - Health Promot Int JT - Health promotion international JID - 9008939 SB - IM MH - Humans MH - Ireland MH - Peer Group MH - Feasibility Studies MH - *Health Promotion/methods/organization & administration MH - *Exercise MH - Adolescent MH - *Schools MH - *Communication MH - Focus Groups MH - *School Health Services/organization & administration MH - Female MH - Surveys and Questionnaires PMC - PMC13445620 OTO - NOTNLM OT - acceptability OT - adolescents OT - appropriateness OT - health literacy OT - messages COIS- The authors have no conflicts of interest to declare. EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 PMCR- 2026/08/06 CRDT- 2026/08/06 09:53 PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 09:53 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 8753138 [pii] AID - daag110 [pii] AID - 10.1093/heapro/daag110 [doi] PST - ppublish SO - Health Promot Int. 2026 Jul 1;41(4):daag110. doi: 10.1093/heapro/daag110. PMID- 42559030 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260927 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Parental perspectives concerning gluten-free food insecurity in households with children with coeliac disease: take away messages for policy makers. PG - e69 LID - 10.1017/jns.2026.10131 [doi] LID - e69 AB - Coeliac disease (CD) is an autoimmune disease resulting in lifelong intolerance to gluten. Treatment of CD is a gluten-free diet (GFD). High gluten-free (GF) food costs contribute to GF-food insecurity (GF-FI) in households with children with CD. The study objective was to describe parental perceptions of the barriers/facilitators of GF-food security (GF-FS) and the health policies parents deem necessary to combat GF-FI. A subset analysis of a cross-sectional study examining household and child socio-demographic, child diet quality and GFD adherence, food environment, and GF-FI in parent-child dyads (n = 59) using validated questionnaires. Virtual interviews included 13 open-and-closed ended questions examining parent perceptions related to barriers/facilitators of GF-FS and health policies to address GF-FI. Questions were validated for face-and-content using an iterative process with parental responses deductively coded using the 5As of food insecurity theoretical framework. High GF-food costs (>90%) and the lack of effective GF-food specific health policies ( approximately 94%) were the most commonly cited barriers to GF-FS, particularly in GF-FI households. Social media (>60%) was used to share information related to tax credits (15%) affordability, accessibility, and availability of GF-foods (75%). Parents deemed child tax credits ( approximately 75%), development of food policies focused on education in schools ( approximately 34%), dietary prescriptions (25%) and official recognition of CD as a disability ( approximately 26%) as important to address GF-FI. In conclusion, parents perceive high GF-food costs and lack of effective GF-food health policies as important mediators of GF-FI. Social media platforms were widely used by the community to share information and solutions to address GF-FI. CI - (c) The Author(s) 2026. FAU - Mager, Diana R AU - Mager DR AUID- ORCID: 0000-0002-5558-8783 AD - Department of Agricultural, Food and Nutritional Sciences, Faculty of Agricultural, Food & Environmental Science, University of Alberta, Canada. ROR: https://ror.org/0160cpw27 AD - Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Canada. FAU - Anders, Sven AU - Anders S AD - Department of Resource Economics & Environmental Sociology, Faculty of Agricultural, Life and Environmental Science, University of Alberta, Canada. FAU - Bruce, Marcia AU - Bruce M AD - Faculty of Medicine, University of Calgary, Canada. FAU - Turner, Justine M AU - Turner JM AD - Department of Agricultural, Food and Nutritional Sciences, Faculty of Agricultural, Food & Environmental Science, University of Alberta, Canada. ROR: https://ror.org/0160cpw27 AD - Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Canada. LA - eng PT - Journal Article DEP - 20260730 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - *Celiac Disease/diet therapy MH - *Diet, Gluten-Free/economics MH - *Food Insecurity MH - Cross-Sectional Studies MH - Child MH - Female MH - Male MH - *Parents/psychology MH - Surveys and Questionnaires MH - Adult MH - Child, Preschool MH - Family Characteristics MH - Adolescent MH - Health Policy MH - *Food Supply PMC - PMC13439013 OTO - NOTNLM OT - Caregiver perspectives OT - Food insecurity OT - Gluten-free diet OT - Policy OT - social media COIS- The authors declare none. EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 PMCR- 2026/07/30 CRDT- 2026/08/06 06:48 PHST- 2025/08/13 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 06:48 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - S2048679026101311 [pii] AID - 10.1017/jns.2026.10131 [doi] PST - epublish SO - J Nutr Sci. 2026 Jul 30;15:e69. doi: 10.1017/jns.2026.10131. eCollection 2026. PMID- 42559005 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260806 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Smartwatch and physical education exam stress: the role of exercise self-efficacy and physical self-concept. PG - 1882938 LID - 10.3389/fpsyt.2026.1882938 [doi] LID - 1882938 AB - Against the backdrop of increasing educational digitalization and growing concerns over adolescent physical health, and based on social cognitive theory, this study examines the associations between attitudes toward smartwatch usage and the stress of junior high school students in the High School Entrance Examination Physical Education (PE examination), and further explores its dynamics through the correlational roles of exercise self-efficacy and physical self-concept. Structural Equation Modeling (SEM) analysis reveals that attitudes toward smartwatch use are directly negatively associated with PE examination stress (beta = -0.197) and are also indirectly associated with lower stress through their positive associations with exercise self-efficacy (indirect effect = -0.108) and physical self-concept (indirect effect = -0.172). In addition, decision tree analysis using the CHAID algorithm identifies physical self-concept as the most critical associated predictive variable. Exercise self-efficacy and attitude toward smartwatch use serve as subsequent hierarchical factors. The findings suggest that smartwatch usage is negatively associated with examination stress by providing objective data feedback and functioning as a "digital mirror", which is associated with boosting students' confidence in exercise and body awareness. The results offer empirical evidence for the application of smart technology in school physical education and propose a "data-driven" correlational framework for understanding adolescents' physical examination stress. Future research could incorporate longitudinal designs and cross-cultural comparisons to further validate the educational relevance of smartwatches, and should also examine potential negative effects such as data-driven anxiety or social comparison. CI - Copyright (c) 2026 Liu, Yang, Cui, Chen and Shi. FAU - Liu, Qi AU - Liu Q AD - School of Teacher Development, Shaanxi Normal University, Xi'an, China. FAU - Yang, Hongli AU - Yang H AD - College of Education for the Future, Beijing Normal University, Zhuhai, China. FAU - Cui, Qi AU - Cui Q AD - School of Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Chen, Jihe AU - Chen J AD - The Faculty of Education, Southwest University, Chongqing, China. FAU - Shi, Bing AU - Shi B AD - Physical Education School, Shaanxi Normal University, Xi'an, China. LA - eng PT - Journal Article DEP - 20260722 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13438291 OTO - NOTNLM OT - adolescent health OT - artificial intelligence OT - exercise self-efficacy OT - physical self-concept OT - smartwatch COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 PMCR- 2026/07/22 CRDT- 2026/08/06 06:46 PHST- 2026/05/16 00:00 [received] PHST- 2026/06/05 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 06:46 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1882938 [doi] PST - epublish SO - Front Psychiatry. 2026 Jul 22;17:1882938. doi: 10.3389/fpsyt.2026.1882938. eCollection 2026. PMID- 42558837 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Design and content validation of AUTIVA: an ecobiopsychosocial instrument for childhood autism. PG - 1768438 LID - 10.3389/fpubh.2026.1768438 [doi] LID - 1768438 AB - There are no community-based surveys for the development or assessment of public policies with an ecobiopsychosocial approach for autistic children. This article reports the development of an instrument assessing characteristics of Chilean autistic children, in order to understand how autism manifests in different environments. This study consisted of two stages: Firstly, after a comprehensive literature review, an instrument was designed by health and education professionals alongside autistic individuals and primary caregivers. Secondly, content validation was performed using the Content Validity Index, through the calculation of the Lawshe Content Validity Ratio. Sixty questions were validated, distributed across six subscales: "General Health Profile" obtained a Content Validity of 0.94; The subscales "Sex and Gender," "Autism Diagnosis and Concomitant Pathologies," "Family Income and the Impact of Autism on Socioeconomic Status," "Diet of the Autistic Person," and "Therapies and Schooling" obtained Content Validity Indexes of 0.89; 0.98; 1.0; 0.96; and 1.0, respectively. The Content Validity Index for the full instrument was 0.96. The survey presented demonstrated initial evidence of content validity and may serve as a basis for future psychometric validation. It allows for the assessment of this population in various life aspects, and offers great potential for creating public care policies regarding this community. As this study represents an initial content validation phase, future research should assess construct validity, criterion-related validity, reliability, and cross-cultural applicability. CI - Copyright (c) 2026 Castillo-Ortega, Hewstone-Garcia, Belmar-Riquelme and Jara-Mella. FAU - Castillo-Ortega, Ruben AU - Castillo-Ortega R AD - Facultad de Cs. Para la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Sede Valdivia, Chile. AD - Vicerrectoria de Vinculacion con el Medio, Universidad San Sebastian, Sede Valdivia, Chile. FAU - Hewstone-Garcia, Carol AU - Hewstone-Garcia C AD - Facultad de Educacion, Universidad San Sebastian, Sede Valdivia, Chile. FAU - Belmar-Riquelme, Gladys AU - Belmar-Riquelme G AD - Facultad de Cs. Para la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Sede Valdivia, Chile. FAU - Jara-Mella, Vannia AU - Jara-Mella V AD - Facultad de Cs. Para la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Sede Valdivia, Chile. LA - eng PT - Journal Article PT - Validation Study DEP - 20260722 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Autistic Disorder/diagnosis/psychology MH - Child MH - Female MH - Male MH - Chile MH - Surveys and Questionnaires/standards MH - Psychometrics MH - Reproducibility of Results MH - Child, Preschool PMC - PMC13438446 OTO - NOTNLM OT - Latin America OT - autism spectrum disorder OT - autistic disorder OT - biopsychosocial models OT - content validity OT - health equity OT - health planning OT - public health surveillance COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 PMCR- 2026/07/22 CRDT- 2026/08/06 06:30 PHST- 2025/12/15 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 06:30 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1768438 [doi] PST - epublish SO - Front Public Health. 2026 Jul 22;14:1768438. doi: 10.3389/fpubh.2026.1768438. eCollection 2026. PMID- 42558385 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Association between inflammatory indicators derived from preconception complete blood count and specific adverse fetal, neonatal, and pregnancy outcomes: a national cohort study. PG - 1886578 LID - 10.3389/fendo.2026.1886578 [doi] LID - 1886578 AB - BACKGROUND: Adverse fetal and neonatal outcomes, including small for gestational age (SGA), large for gestational age (LGA), and low birth weight (LBW), seriously endanger maternal and infant health. Currently, the associations between preconception baseline immune-inflammatory status and the above specific adverse pregnancy outcomes still lack systematic population-based cohort evidence. METHODS: Based on the National Free Preconception Health Examination Program in China from 2010 to 2012, this large-sample cohort study recruited rural women of childbearing age in China. Multivariate logistic regression and restricted cubic spline (RCS) models were used to systematically analyze the associations between preconception complete blood count (CBC)-derived inflammatory indicators, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and adverse fetal, neonatal, and pregnancy outcomes. RESULTS: A total of 49,855 preconception participants were enrolled in this study, among whom 16,105 cases experienced adverse fetal and neonatal outcomes. Quartile analysis revealed distinct outcome-specific associations of inflammatory indicators. Moderate levels of NLR increased the risk of SGA, while moderate NLR and SII levels reduced the risk of LGA; the highest quartile of PLR elevated the risk of LGA, and moderate NLR decreased the risk of preterm birth. Only high levels of NLR exerted a protective effect against HBW. Further RCS analyses confirmed significant U-shaped nonlinear associations of NLR, PLR, and SII with LGA, as well as U-shaped correlations of PLR and SII with preterm birth, indicating obvious threshold effects of preconception inflammation on pregnancy outcomes. CONCLUSION: After adjusting available covariates, preconception NLR, PLR, and SII exhibited outcome-specific threshold associations with adverse fetal and neonatal outcomes, yet unmeasured confounders (preconception infection, maternal nutrition, etc.) may overestimate these correlations. Owing to the large sample, many significant results carry modest effect sizes with limited individual clinical utility; these markers merely offer population-based epidemiological references instead of standalone screening indicators for rural preconception risk stratification. Our results require validation in modern urban and multicenter cohorts due to the historical rural-only study population. CI - Copyright (c) 2026 Jiang, Song, Du, Zhang, Chen and Pan. FAU - Jiang, Yue AU - Jiang Y AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Song, Shuaihua AU - Song S AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Du, Hanze AU - Du H AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Zhang, Liyuan AU - Zhang L AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Chen, Shi AU - Chen S AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Pan, Hui AU - Pan H AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. LA - eng PT - Journal Article DEP - 20260722 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pregnancy Outcome/epidemiology MH - Adult MH - Infant, Newborn MH - *Inflammation/blood/epidemiology MH - Infant, Large for Gestational Age MH - China/epidemiology MH - Cohort Studies MH - Blood Cell Count MH - Infant, Small for Gestational Age MH - Young Adult MH - *Biomarkers/blood MH - *Pregnancy Complications/blood/epidemiology MH - Infant, Low Birth Weight PMC - PMC13437505 OTO - NOTNLM OT - complete blood count OT - inflammatory indicators OT - preconception inflammation OT - pregnancy complications OT - specific adverse pregnancy outcomes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 11:36 MHDA- 2026/08/06 11:37 PMCR- 2026/07/22 CRDT- 2026/08/06 05:42 PHST- 2026/05/20 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/08/06 11:37 [medline] PHST- 2026/08/06 11:36 [pubmed] PHST- 2026/08/06 05:42 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fendo.2026.1886578 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jul 22;17:1886578. doi: 10.3389/fendo.2026.1886578. eCollection 2026. PMID- 42558370 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Knee symptoms among college students and their relationship with physical activity behaviors: a cross-sectional survey. PG - 1879925 LID - 10.3389/fpubh.2026.1879925 [doi] LID - 1879925 AB - OBJECTIVES: To investigate the prevalence of knee symptoms among Chinese college students, and then to analyze the association between physical activities or other factors and knee symptoms. METHODS: Electronic questionnaires on knee symptoms, engagement in physical activity and other variables were administered from June to November 2022. Valid data were analyzed for 1,111 college students. The potential factors associated with knee symptoms were estimated using logistic regression models. RESULTS: The prevalence of knee symptoms among Chinese college students was 17.37, and 37.44% of students reported knee sounds after prolonged sitting or standing. After adjusting for other factors, moderate-to-high level of vigorous physical activity (odds ratio [OR] = 2.66; 95% confidence interval [CI]: 1.40-5.06; p < 0.001) or climbing over 20 floors per day (OR = 2.37; 95% CI: 1.06-5.29; p < 0.05) were significantly associated with increased odds of knee symptoms in college students. In addition to knee sounds (OR = 3.54; 95% CI = 2.43-5.16; p < 0.001), knee injury (OR = 7.13; 95% CI = 4.30-11.82; p < 0.001) had the most influence on the prevalence of knee symptoms. CONCLUSION: Targeted interventions should be implemented to improve knee health among college students and promote tailored participation in physical activity. CI - Copyright (c) 2026 Wang, Teng, Li and He. FAU - Wang, Limin AU - Wang L AD - School of Nurisng, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. FAU - Teng, Peimeng AU - Teng P AD - School of Nurisng, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. FAU - Li, Qingqing AU - Li Q AD - School of Nurisng, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. FAU - He, Guijuan AU - He G AD - School of Nurisng, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260722 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/statistics & numerical data MH - *Exercise MH - Female MH - Cross-Sectional Studies MH - Universities MH - Young Adult MH - Male MH - China/epidemiology MH - Prevalence MH - Surveys and Questionnaires MH - Adolescent MH - *Knee Joint/physiopathology MH - *Knee Injuries/epidemiology MH - Adult PMC - PMC13437316 OTO - NOTNLM OT - college student OT - exercise OT - knee health OT - knee symptoms OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 11:36 MHDA- 2026/08/06 11:37 PMCR- 2026/07/22 CRDT- 2026/08/06 05:41 PHST- 2026/05/13 00:00 [received] PHST- 2026/07/04 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/08/06 11:37 [medline] PHST- 2026/08/06 11:36 [pubmed] PHST- 2026/08/06 05:41 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1879925 [doi] PST - epublish SO - Front Public Health. 2026 Jul 22;14:1879925. doi: 10.3389/fpubh.2026.1879925. eCollection 2026. PMID- 42558339 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260806 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Global trends and emerging themes in youth physical literacy research: a bibliometric analysis (2000-2025). PG - 1859748 LID - 10.3389/fspor.2026.1859748 [doi] LID - 1859748 AB - BACKGROUND: Physical literacy (PL) has emerged as an important framework for understanding children's and adolescents' motivation, confidence, physical competence, knowledge, and engagement in lifelong physical activity. Although youth physical literacy research has expanded rapidly, limited bibliometric evidence has systematically mapped its global development, intellectual structure, and emerging thematic trends. This study aimed to examine the evolution of youth physical literacy research from 2000 to 2025 and identify major research themes, collaboration patterns, and emerging directions. MATERIALS AND METHODS: A bibliometric analysis was conducted using records retrieved from the Web of Science Core Collection and Scopus databases within a multi-database validation framework. After data cleaning, deduplication, and exclusion of records outside the study period, 856 publications published between 2000 and 2025 were included. Bibliometrix, VOSviewer, and CiteSpace were used to examine publication trends, collaboration networks, influential contributors, keyword co-occurrence patterns, thematic clusters, timeline evolution, and burst keywords. RESULTS: Youth physical literacy research showed a sustained increase in publications, particularly after 2015. Canada, Australia, China, the United States, and the United Kingdom were among the most productive countries. Keyword and cluster analyses identified major themes related to physical education, motor competence, physical activity, physical competence, assessment and validation, fitness, health literacy, and public health. Timeline and burst analyses further suggested increasing attention to psychological, educational, and well-being-related themes within the youth physical literacy literature. Cross-database comparison showed consistent patterns in publication trends, leading contributors, and core thematic structures, supporting the robustness of the identified research patterns. CONCLUSION: This study provides a systematic and validated mapping of the global research landscape of youth physical literacy from 2000 to 2025. The findings suggest that youth physical literacy research has expanded from physical education, motor competence, and assessment-oriented topics toward broader educational, psychosocial, and health-related themes. These results offer a knowledge map for researchers, educators, and policymakers interested in advancing youth physical literacy in educational contexts and supporting holistic student development. CI - (c) 2026 Zishan and Mohd Hashim. FAU - Zishan, Zhao AU - Zishan Z AD - Faculty of Educational Sciences and Technology, Universiti Teknologi Malaysia, Johor Bahru, Malaysia. FAU - Mohd Hashim, Asha Hasnimy AU - Mohd Hashim AH AD - Faculty of Educational Sciences and Technology, Universiti Teknologi Malaysia, Johor Bahru, Malaysia. LA - eng PT - Journal Article DEP - 20260722 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13437538 OTO - NOTNLM OT - bibliometric analysis OT - motor competence OT - physical activity OT - physical education OT - physical literacy OT - science mapping OT - youth COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 11:36 MHDA- 2026/08/06 11:37 PMCR- 2026/07/22 CRDT- 2026/08/06 05:39 PHST- 2026/04/19 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/08/06 11:37 [medline] PHST- 2026/08/06 11:36 [pubmed] PHST- 2026/08/06 05:39 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fspor.2026.1859748 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jul 22;8:1859748. doi: 10.3389/fspor.2026.1859748. eCollection 2026. PMID- 42558337 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Optimal cutoff values of alanine aminotransferase and its derived markers for pediatric MASLD. PG - 1808797 LID - 10.3389/fendo.2026.1808797 [doi] LID - 1808797 AB - BACKGROUND: The early detection of metabolic dysfunction-associated steatotic liver disease (MASLD) is essential. This study aims to evaluate the diagnostic utility and optimal cutoffs of alanine aminotransferase (ALT) and its derived markers, including the ALT/aspartate aminotransferase (AST) and ALT/high-density lipoprotein cholesterol (HDL) ratios, for predicting pediatric MASLD. METHODS: We analyzed data from 1,158 adolescents in the National Health and Nutritional Examination Survey (NHANES) and 263 adolescents from a real-world clinical cohort. MASLD was assessed using vibration-controlled transient elastography in the NHANES cohort and abdominal ultrasonography in the clinical cohort. Logistic regression and receiver operating characteristic (ROC) curve analyses were conducted to evaluate associations and predictive performance. RESULTS: ALT, ALT/AST, and ALT/HDL were significantly associated with MASLD in both datasets, even after adjusting for age and sex (all p < 0.001). In the NHANES cohort, the areas under the ROC curves (AUCs) for ALT, ALT/AST, and ALT/HDL were 0.73, 0.77, and 0.76, respectively, with optimal cutoff values of >14.50 for ALT, >0.74 for ALT/AST, and >0.29 for ALT/HDL in the total population. In the real-world clinical cohort, the corresponding AUCs were 0.84, 0.84, and 0.86, respectively. ALT/HDL demonstrated the highest AUC in both datasets, reaching 0.92 in females in the clinical cohort. CONCLUSIONS: ALT and ALT-derived markers are valuable for predicting pediatric MASLD. Among them, the ALT/HDL ratio demonstrated the best predictive performance, indicating that composite indices integrating markers of hepatic injury and metabolic status may enhance early detection of MASLD in children and adolescents. CI - Copyright (c) 2026 Kim, Lee, Lee, Youn, Baik, Shin, Kwon, Lee, Chae and Song. FAU - Kim, Joon Young AU - Kim JY AD - Gangnam Severance Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Lee, Eunju AU - Lee E AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Lee, Hye Sun AU - Lee HS AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Youn, Young Hoon AU - Youn YH AD - Gangnam Severance Hospital, Health Promotion Center, Healthcare Research Team, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Baik, Su Jung AU - Baik SJ AD - Gangnam Severance Hospital, Health Promotion Center, Healthcare Research Team, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Shin, Hyun Joo AU - Shin HJ AD - Yongin Severance Hospital, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Department of Radiology, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Kwon, Yu-Jin AU - Kwon YJ AD - Yongin Severance Hospital, Department of Family Medicine, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Lee, Eun Byoul AU - Lee EB AD - Yongin Severance Hospital, Department of Pediatrics, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Chae, Hyun Wook AU - Chae HW AD - Gangnam Severance Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Song, Kyungchul AU - Song K AD - Gangnam Severance Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20260722 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - EC 2.6.1.2 (Alanine Transaminase) RN - 0 (Biomarkers) RN - EC 2.6.1.1 (Aspartate Aminotransferases) SB - IM MH - Humans MH - Female MH - *Alanine Transaminase/blood MH - Male MH - *Biomarkers/blood MH - Adolescent MH - Child MH - ROC Curve MH - Nutrition Surveys MH - *Fatty Liver/diagnosis/blood MH - Aspartate Aminotransferases/blood PMC - PMC13437452 OTO - NOTNLM OT - adolescent OT - biomarkers OT - child OT - early diagnosis OT - fatty liver OT - liver function tests COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 11:36 MHDA- 2026/08/06 11:37 PMCR- 2026/07/22 CRDT- 2026/08/06 05:39 PHST- 2026/02/11 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/06 11:37 [medline] PHST- 2026/08/06 11:36 [pubmed] PHST- 2026/08/06 05:39 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fendo.2026.1808797 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jul 22;17:1808797. doi: 10.3389/fendo.2026.1808797. eCollection 2026. PMID- 42557830 OWN - NLM STAT- Publisher LR - 20260806 IS - 1541-3144 (Electronic) IS - 0194-2638 (Linking) DP - 2026 Aug 5 TI - Comparison of Synchronous Telerehabilitation and Face-to-Face Methods on Upper Extremity Function in Children with Hemiparetic Cerebral Palsy. PG - 1-19 LID - 10.1080/01942638.2026.2709463 [doi] AB - AIMS: This study investigates whether synchronous telerehabilitation improves upper extremity function in children with hemiparetic cerebral palsy (CP). METHODS: Children aged 6-12 with Manual Ability Classification System (MACS) levels I-III were randomized into two groups. One group received Bilateral Activity-Based Exercise Training (BiActBET) in a clinic, while the other group received it via synchronous telerehabilitation (2 sessions/week for 12 weeks). The evaluations (the Quality of Upper Extremity Skills Test (QUEST), Shriners Hospital Upper Extremity Evaluation (SHUEE), ABILHAND-Kids Scale, Modified Tardieu Scale (MTS), Selective Control of the Upper Extremity Scale (SCUES), range of motion (ROM), Pediatric Evaluation of Disability Inventory (PEDI), and Cerebral Palsy Quality of Life Questionnaire for Children (CPQOL-Child)) were conducted face-to-face. Treatment efficacy, improvement, and satisfaction were also questioned. RESULTS: Both groups showed statistically significant improvements in all outcome measures (p < 0.001), with large effect sizes, with no comparison showing superiority (p > 0.05). Caregiver-rated effectiveness and improvement were similar between groups (both p = 0.183), but satisfaction was higher in the face-to-face group (p < 0.001). CONCLUSION: BiActBET enhances upper extremity function through both delivery methods. Synchronous telerehabilitation is a feasible, accessible option, associated with improvements in measured spasticity-related parameters (MTS outcomes), selective motor control, ROM, independence, and quality of life, though face-to-face therapy yields greater satisfaction. FAU - Altun, Gamze Polen AU - Altun GP AUID- ORCID: 0000-0003-0036-8668 AD - Department of Physiotherapy and Rehabilitation, Institute of Graduate Studies, Istanbul University-Cerrahpasa, Istanbul, Turkiye. FAU - Zengin Alpozgen, Ayse AU - Zengin Alpozgen A AUID- ORCID: 0000-0003-0436-1164 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260805 PL - England TA - Phys Occup Ther Pediatr JT - Physical & occupational therapy in pediatrics JID - 8109120 SB - IM OTO - NOTNLM OT - Arm function OT - bilateral training OT - cerebral palsy OT - online health EDAT- 2026/08/06 11:36 MHDA- 2026/08/06 11:36 CRDT- 2026/08/06 02:13 PHST- 2026/08/06 11:36 [medline] PHST- 2026/08/06 11:36 [pubmed] PHST- 2026/08/06 02:13 [entrez] AID - 10.1080/01942638.2026.2709463 [doi] PST - aheadofprint SO - Phys Occup Ther Pediatr. 2026 Aug 5:1-19. doi: 10.1080/01942638.2026.2709463. PMID- 42557588 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Aug 6 TI - Assessment of cardiometabolic risk using single point insulin sensitivity estimator (SPISE) in pediatric Bardet-Biedl Syndrome: a pilot study. LID - 10.1186/s13023-026-04353-y [doi] LID - 266 AB - BACKGROUND: Bardet-Biedl syndrome (BBS) carries early cardiometabolic risk, yet pediatric screening is complicated by growth and puberty. The metabolic syndrome (MetS) z-score provides a continuous benchmark for clustered risk. The single-point insulin sensitivity estimator (SPISE), based on body mass index (BMI) and fasting lipids, may offer a practical alternative where insulin testing is impractical. We aimed to assess the association between SPISE and cardiometabolic burden in children with molecularly confirmed BBS, and to compare its ability to identify MetS against the MetS z-score benchmark and insulin-derived indices. METHODS: Single-center retrospective pilot study including children/adolescents with genetically confirmed BBS who underwent standardized anthropometry and metabolic profiling (fasting lipids, glucose, insulin; OGTT when available). SPISE-MetS z-score associations were examined using Spearman and adjusted analyses. In adolescents (>/= 10 years), MetS discrimination was evaluated with ROC curves for SPISE, TG/HDL, and homeostatic model assessment for insulin resistance (HOMA-IR), with pairwise DeLong comparisons and Youden-optimal thresholds. RESULTS: Fourteen participants (7 females, 7 males) were evaluated. Median age at last visit was 11.7 years [IQR 7.6-15.5]; BMI SDS was 3.05 [2.47-3.57]. The median MetS z-score was 1.60 [0.90-1.75]. SPISE correlated inversely with the MetS z-score (rho=-0.57, p = 0.021), and adjusted models (age, sex, BMI-SDS) retained significance. Among adolescents (n = 10), SPISE showed the highest AUC for MetS (AUC 0.95; 95% CI 0.82-1.00) versus TG/HDL (AUC 0.81) and HOMA-IR (AUC 0.60); pairwise differences were not statistically significant. Youden-optimal SPISE 0.05). Stroke index and swimming speed (real and synthetic) showed moderate to very strong associations with 1500 m time in both male (r = -0.53 to -0.76) and female swimmers (r = -0.54 to -0.97). In the male model, performance is primarily driven by variables related to stroke efficiency, maximal oxygen uptake, and high-intensity physiological strain. The female model places greater emphasis on pacing-related variables, including mean swimming speed during endurance and [La(-)] tolerance tests, anaerobic threshold velocity, and metabolic stress indicators. Symbolic regression applied to synthetic datasets is suitable to address the small sample size limitations often present in human research, particularly swimming. Coaches and researchers are encouraged to use symbolic regression and synthetic data and to report the resulting equations to support mechanistic interpretation of 1500 m performance prediction equations for male and female swimmers. FAU - Chainok, Phornpot AU - Chainok P AUID- ORCID: 0000-0003-2605-4181 AD - Faculty of Sport Science, Burapha University, Thailand. FAU - Matjiur, Radomyos AU - Matjiur R AUID- ORCID: 0009-0000-9835-6192 AD - Faculty of Sport Science, Burapha University, Thailand. FAU - de Jesus, Karla AU - de Jesus K AUID- ORCID: 0000-0002-7710-9843 AD - Human Performance Laboratory, Faculty of Physical Education and Physiotherapy, Federal University of Amazonas, Brazil. FAU - Dos Santos Coelho, Leandro AU - Dos Santos Coelho L AUID- ORCID: 0000-0001-5728-943X AD - Department of Electrical Engineering, Federal University of Parana, Parana, Brazil. FAU - Cocco Mariani, Viviana AU - Cocco Mariani V AUID- ORCID: 0000-0003-2490-4568 AD - Department of Electrical Engineering, Federal University of Parana, Parana, Brazil. AD - Mechanical Engineering Graduate Program, Federal University of Parana, Parana, Brazil. FAU - Zacca, Rodrigo AU - Zacca R AUID- ORCID: 0000-0003-0494-0000 AD - Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADEUP), Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal. AD - Nucleus of Research in Human Motricity Sciences, Universidad Adventista de Chile, Chillan, Chile. AD - Laboratory of Sport Physiology, Faculty of Sports, University of Porto, Porto, Portugal. FAU - Fernandes, Ricardo J AU - Fernandes RJ AUID- ORCID: 0000-0002-5811-0443 AD - Centre for Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport (FADEUP), University of Porto, Porto, Portugal. AD - Porto Biomechanics Laboratory (LABIOMEP), University of Porto, Porto, Portugal. FAU - Vilas-Boas, Joao Paulo AU - Vilas-Boas JP AUID- ORCID: 0000-0002-4109-2939 AD - Centre for Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport (FADEUP), University of Porto, Porto, Portugal. AD - Porto Biomechanics Laboratory (LABIOMEP), University of Porto, Porto, Portugal. LA - eng PT - Journal Article DEP - 20260805 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *Swimming/physiology MH - Female MH - *Athletic Performance/physiology MH - Male MH - Biomechanical Phenomena MH - Oxygen Consumption/physiology MH - Adolescent MH - Body Composition MH - Regression Analysis MH - Physical Endurance/physiology MH - Anaerobic Threshold/physiology MH - Anthropometry MH - Stress, Physiological OTO - NOTNLM OT - Biomechanics OT - Exercise physiology OT - Interpretable machine learning OT - Long-Distance Events OT - Sports analytics OT - Swimming OT - Symbolic learning OT - interpretability OT - modelling EDAT- 2026/08/05 13:37 MHDA- 2026/08/28 11:49 CRDT- 2026/08/05 08:13 PHST- 2026/08/28 11:49 [medline] PHST- 2026/08/05 13:37 [pubmed] PHST- 2026/08/05 08:13 [entrez] AID - 10.1080/02640414.2026.2710467 [doi] PST - ppublish SO - J Sports Sci. 2026 Aug;44(16):2065-2082. doi: 10.1080/02640414.2026.2710467. Epub 2026 Aug 5. PMID- 42554309 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) VI - 62 IP - 10 DP - 2026 Oct TI - The Performance of the STRONGkids Nutrition Screening Tool Following Nurse Training in a Tertiary Care Setting. PG - 1894-1900 LID - 10.1111/jpc.70515 [doi] AB - AIM: The low sensitivity of STRONGkids, a nutrition risk screening tool, was observed during its implementation in patient care services at a tertiary care hospital. The screening process improvement was performed to enhance its effectiveness. This study aimed to evaluate the validity and inter-rater reliability of the screening tool after the improvement process. METHODS: This was a cross-sectional study that collected baseline characteristics and clinical data from medical records. STRONGkids score and risk classification were recorded by ward nurses. Concurrent validity was assessed with respect to nutritional status, including undernutrition (BMI Z-score < -2), stunting (height-for-age Z-score < -2), and overall malnutrition (including both undernutrition and stunting). Nutrition risk screening was repeated by a nutrition nurse to determine inter-rater reliability. RESULTS: The study enrolled 1419 paediatric admissions. Undernutrition, stunting, and overall malnutrition were observed in 13%, 17%, and 27.6% of participants, respectively. STRONGkids classified 24%, 71.1%, and 4.9% of patients as having low, moderate, and high nutrition risk, respectively. Patients with high nutrition risk had significantly longer hospital stays and higher rates of hospital-acquired infections. STRONGkids demonstrated sensitivities of 82.4%-82.6% and specificities of 25%-26.5% for nutrition status. Inter-rater reliability was assessed across 320 admissions and showed excellent reliability for both the total score (k = 0.84; p < 0.001) and risk categories (k = 0.89; p < 0.001). CONCLUSION: The performance of the nutrition risk screening tool may differ from that observed in research settings when used in routine clinical practice. STRONGkids demonstrates satisfactory validity and inter-rater reliability after the improvement process. CI - (c) 2026 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Ngamboriruk, Punthita AU - Ngamboriruk P AD - Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. FAU - Dumrongwongsiri, Oraporn AU - Dumrongwongsiri O AD - Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. FAU - Phoonlapdacha, Phanphen AU - Phoonlapdacha P AD - Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. LA - eng PT - Journal Article DEP - 20260805 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Nutrition Assessment MH - Reproducibility of Results MH - Female MH - Tertiary Care Centers MH - *Mass Screening/methods MH - Male MH - *Malnutrition/diagnosis MH - Child, Preschool MH - Nutritional Status MH - Infant MH - Sensitivity and Specificity MH - *Child Nutrition Disorders/diagnosis OTO - NOTNLM OT - STRONGkids OT - hospitalised children OT - malnutrition OT - nutritional screening EDAT- 2026/08/05 13:37 MHDA- 2026/10/15 23:30 CRDT- 2026/08/05 07:53 PHST- 2026/06/28 00:00 [revised] PHST- 2026/04/28 00:00 [received] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/10/15 23:30 [medline] PHST- 2026/08/05 13:37 [pubmed] PHST- 2026/08/05 07:53 [entrez] AID - 10.1111/jpc.70515 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Oct;62(10):1894-1900. doi: 10.1111/jpc.70515. Epub 2026 Aug 5. PMID- 42553825 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 0973-6131 (Print) IS - 2231-2714 (Electronic) IS - 0973-6131 (Linking) VI - 19 IP - 2 DP - 2026 May-Aug TI - Effect of Adjuvant Yoga Therapy for Chronic Respiratory Diseases in Pediatric Population - A Scoping Review. PG - 128-138 LID - 10.4103/ijoy.ijoy_147_25 [doi] AB - Chronic respiratory diseases (CRD), i.e., asthma, COPD, allergic rhinitis, and tuberculosis, account for approximately one-third of emergency hospitalizations. As a holistic therapy, yoga has the potential to improve both the physical and psychological well-being of individuals with CRD, and its popularity has expanded globally. However, studies assessing yoga's effects have yielded inconsistent results. The scoping review adhered to the PRISMA Extension for scoping reviews, PRISMA-ScR. A protocol was registered on OSF (10.17605/OSF.IO/Q6CKN). We conducted a systematic search on PubMed, Embase, and Scopus, covering studies from inception till december-2024. Inclusion criteria were a pediatric population with CRD, yoga as adjuvant therapy, and English language publications. Data were extracted systematically and categorized based on publication year, author, type of study, country, disease, and intervention. We included 552 database results with 2357 patients, published between 1985 and 2023. Most studies were primarily from India (n = 15), focused on asthma, along with two studies on cystic fibrosis and one each on pleural effusion and bronchiectasis. Study types included observational studies (n = 10), randomized controlled trials (n = 8), controlled trials (n = 1), quasi-experimental studies (n = 1), and pilot studies (n = 2). Yoga improved pulmonary function test scores in asthma, pleural effusion, and bronchiectasis, enhancing quality of life (QOL) and psychological well-being. However, no studies were found on COPD, pneumonia, and tuberculosis in the pediatric population. Quality evidence suggests that yoga improves asthma symptoms and QOL. However, variations in yoga modules limit generalizability. Future research should develop validated disease-specific modules, including unexplored facets like Yama, Niyama, yogic counseling, and diet. Mechanistic studies with long follow-up periods are needed. CI - Copyright: (c) 2026 International Journal of Yoga. FAU - Mahendru, Monica AU - Mahendru M AD - Department of Pediatrics, AIIMS, Rishikesh, Uttarakhand, India. FAU - Mohanty, Sriloy AU - Mohanty S AD - Department of Ayush, AIIMS, Rishikesh, Uttarakhand, India. FAU - Dabas, Dheeraj AU - Dabas D AD - Department of Telemedicine and Biomedical Informatics, AIIMS, Rishikesh, Uttarakhand, India. FAU - Malik, Vivek Singh AU - Malik VS AD - Department of Evidence Synthesis, AIIMS, Rishikesh, Uttarakhand, India. AD - Department of Telemedicine and Biomedical Informatics, AIIMS, Rishikesh, Uttarakhand, India. AD - Cochrane Evidence Synthesis Unit, AIIMS, Rishikesh, Uttarakhand, India. FAU - Singh, Meenu AU - Singh M AD - Department of Evidence Synthesis, AIIMS, Rishikesh, Uttarakhand, India. AD - Department of Telemedicine and Biomedical Informatics, AIIMS, Rishikesh, Uttarakhand, India. AD - Cochrane Evidence Synthesis Unit, AIIMS, Rishikesh, Uttarakhand, India. LA - eng PT - Journal Article PT - Review DEP - 20260625 PL - India TA - Int J Yoga JT - International journal of yoga JID - 101313247 PMC - PMC13436610 OTO - NOTNLM OT - Asthma OT - Yoga OT - cystic fibrosis OT - pulmonary function test COIS- There are no conflicts of interest. EDAT- 2026/08/05 06:41 MHDA- 2026/08/05 06:42 PMCR- 2026/05/01 CRDT- 2026/08/05 05:49 PHST- 2025/06/04 00:00 [received] PHST- 2025/11/05 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/08/05 06:41 [pubmed] PHST- 2026/08/05 05:49 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - IJY-19-128 [pii] AID - 10.4103/ijoy.ijoy_147_25 [doi] PST - ppublish SO - Int J Yoga. 2026 May-Aug;19(2):128-138. doi: 10.4103/ijoy.ijoy_147_25. Epub 2026 Jun 25. PMID- 42553681 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - "Look at me, not your screen": the negative association of parental phubbing on adolescent well-being. PG - 1869469 LID - 10.3389/fpsyt.2026.1869469 [doi] LID - 1869469 AB - Against the backdrop of rapid digital technology development, the impact of parental phubbing on adolescents' physical and mental health has garnered increasing attention. Grounded in the Stimulus-Organism-Response (SOR) theoretical model, this study examines the statistical associations linking parental phubbing to adolescents' anxiety levels and participation in physical activity. Data were collected from 550 middle school students using the Parental Phubbing Scale (PPS), the Generalized Anxiety Disorder-7 (GAD-7), the Social Anxiety Disorder Scale-7 (SAD-7), and the Physical Activity Rating Scale-3 (PARS-3). After excluding 41 invalid responses, 509 valid questionnaires were included in the final analysis. The findings reveal that frequent parental phubbing is significantly positively associated with adolescents' generalized anxiety and social anxiety, and negatively associated with their engagement in physical activity. Network analysis further shows that generalized anxiety emerges as a central hub in the network, whereas social anxiety exhibits a distinct suppressive moderating effect. These results highlight the potential harm of shifting family interaction patterns in the digital age and emphasize the need for parents to be mindful of the modeling effects of their device use. Strengthening face-to-face interactions may help promote adolescents' physical and psychological well-being. These findings offer correlational evidence that may inform the establishment of family digital behavior guidelines and the development of intervention strategies to support adolescent health. CI - Copyright (c) 2026 Liu, Cui, Dang, Chen and Shi. FAU - Liu, Qi AU - Liu Q AD - School of Teacher Development, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Cui, Qi AU - Cui Q AD - School of Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Dang, Myduyen AU - Dang M AD - The Faculty of Chinese Language and Culture, Dong A University, Danang, Vietnam. FAU - Chen, Jihe AU - Chen J AD - The Faculty of Education, Southwest University, Beibei, Chongqing, China. FAU - Shi, Bing AU - Shi B AD - Physical Education School, Shaanxi Normal University, Xi'an, Shaanxi, China. LA - eng PT - Journal Article DEP - 20260721 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13435843 OTO - NOTNLM OT - adolescent well-being OT - generalized anxiety OT - parental phubbing OT - physical activity OT - social anxiety COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/07/21 CRDT- 2026/08/05 05:40 PHST- 2026/04/30 00:00 [received] PHST- 2026/06/05 00:00 [revised] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 05:40 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1869469 [doi] PST - epublish SO - Front Psychiatry. 2026 Jul 21;17:1869469. doi: 10.3389/fpsyt.2026.1869469. eCollection 2026. PMID- 42553270 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Integrating telemedicine into nutritional management of infants with inherited metabolic disorders: a pilot study. PG - 1869508 LID - 10.3389/fped.2026.1869508 [doi] LID - 1869508 AB - BACKGROUND: Several inherited metabolic disorders (IMDs) require intensive and continuous nutritional management, particularly during the first year of life. Telemedicine (TM) may support care delivery in this setting, but evidence in infants remains limited. OBJECTIVE: The aim of this pilot study was to assess the feasibility and acceptability of integrating TM into routine nutritional management of infants with IMDs identified through newborn screening. METHODS: Caregivers of infants with IMDs requiring nutritional management were asked to choose between telemedicine-integrated follow-up (TM group) or exclusively in-person care (NO-TM group). Anthropometric parameters and clinical signs of malnutrition were assessed at birth, 6, and 12 months of life. All measured disease-specific biomarkers were collected. Caregivers assigned to the TM group completed structured questionnaires evaluating TM satisfaction and patients' quality of life. RESULTS: Nine infants with confirmed IMDs were enrolled and followed for 12 months. Seven patients (78%) were managed with TM integration. Growth trajectories and metabolic outcomes remained within expected clinical targets in both groups, and no clinical signs of malnutrition were observed in any patient. Disease-specific biomarkers in patients with phenylketonuria and citrullinemia type I remained within target ranges in both groups, with more stable phenylalanine levels observed in patients in the TM group. Caregivers reported high satisfaction with TM (median score: 94.5% of the maximum possible score). Quality of life scores were high in all patients. CONCLUSIONS: In this small pilot cohort, partial integration of TM into nutritional management of infants with IMDs appeared feasible, was well accepted by caregivers, and was not affected by evident adverse effects on growth or metabolic control during the first year of life. Larger studies are needed to confirm these observations and support wider implementation. CI - (c) 2026 Tagi, Montanari, Tosi, Stucchi, Cartalemi, Gandini, Eletti, Perico, Borsani, Fiori, Calcaterra and Zuccotti. FAU - Tagi, Veronica Maria AU - Tagi VM AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. FAU - Montanari, Chiara AU - Montanari C AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. FAU - Tosi, Martina AU - Tosi M AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Department of Health Sciences, University of Milan, Milan, Italy. FAU - Stucchi, Eliana AU - Stucchi E AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Cartalemi, Aurora Maria Esmeralda AU - Cartalemi AME AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Gandini, Letizia AU - Gandini L AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Eletti, Francesca AU - Eletti F AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Perico, Veronica AU - Perico V AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. FAU - Borsani, Barbara AU - Borsani B AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Fiori, Laura AU - Fiori L AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Calcaterra, Valeria AU - Calcaterra V AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. LA - eng PT - Journal Article DEP - 20260721 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13433604 OTO - NOTNLM OT - citrullinemia type I OT - growth OT - infants OT - inherited metabolic disorders (IMD) OT - nutritional management OT - phenylketonuria (PKU) OT - quality of life OT - telemedicine COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/05 06:41 MHDA- 2026/08/05 06:42 PMCR- 2026/07/21 CRDT- 2026/08/05 05:03 PHST- 2026/04/30 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/08/05 06:41 [pubmed] PHST- 2026/08/05 05:03 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.3389/fped.2026.1869508 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 21;14:1869508. doi: 10.3389/fped.2026.1869508. eCollection 2026. PMID- 42553178 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2096-7071 (Electronic) IS - 2096-7071 (Linking) VI - 8 IP - 28 DP - 2026 Jul 10 TI - Nomogram for Predicting Myopia Risk in Chinese Children and Adolescents Aged 5-19 Years - 10 PLADs, China 2020-2024. PG - 892-897 LID - 10.46234/ccdcw2026.145 [doi] AB - INTRODUCTION: This study aimed to identify the determinants of myopia in children and adolescents across 10 provincial-level administrative divisions (PLADs) and develop a predictive nomogram to aid risk identification. METHODS: From November 2020 to July 2024, 32,075 students aged 5-19 years were selected using stratified cluster random sampling across 10 PLADs. Myopia screening and questionnaires were used to collect demographic, behavioral, and environmental data. To account for the hierarchical structure of the data, multilevel logistic regression was employed to identify the independent predictors of myopia. A nomogram was constructed based on the regression coefficients, following the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) guidelines. The model performance was evaluated using receiver operating characteristic (ROC) curves, area under the curve (AUC), calibration plots, and decision curve analysis (DCA). RESULTS: The prevalence of myopia was 29.49% (9,460/32,075). Sex, daily frequency of school eye exercises, homework/reading and writing time after school, time spent on computers, 33-centimeter eye-to-book distance during reading and writing, 3-meter eye-to-TV distance, lying or prone position for reading/screen, parent-controlled game time, and parental myopia were identified as significant predictors. The nomogram demonstrated strong predictive ability, with AUCs of 0.80 (training) and 0.81 (validation), good calibration, and a high net clinical benefit in DCA. CONCLUSION: The developed nomogram proved effective for identifying high-risk children, supporting personalized risk stratification, and targeting early intervention strategies. CI - Copyright (c) 2026 by Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine. FAU - Liu, Keke AU - Liu K AD - School of Public Health, Capital Medical University, Beijing, China. AD - School Health Center, Beijing Center for Disease Control and Prevention, Beijing, China. FAU - Qin, Ran AU - Qin R AD - School Health Center, Beijing Center for Disease Control and Prevention, Beijing, China. FAU - Luo, Huijuan AU - Luo H AD - School Health Center, Beijing Center for Disease Control and Prevention, Beijing, China. FAU - Guo, Xin AU - Guo X AD - School of Public Health, Capital Medical University, Beijing, China. AD - School Health Preparation Office, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China. LA - eng PT - Journal Article PL - China TA - China CDC Wkly JT - China CDC weekly JID - 101767554 PMC - PMC13433276 OTO - NOTNLM OT - Children and adolescents OT - Myopia OT - Nomogram OT - Risk factors COIS- No conflicts of interest. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/07/10 CRDT- 2026/08/05 04:52 PHST- 2026/02/09 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 04:52 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - ccdcw-8-28-892 [pii] AID - 10.46234/ccdcw2026.145 [doi] PST - ppublish SO - China CDC Wkly. 2026 Jul 10;8(28):892-897. doi: 10.46234/ccdcw2026.145. PMID- 42553102 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Associations between early childhood appetitive traits and dietary diversity in school-age children: a two-year longitudinal follow-up study. PG - 1824771 LID - 10.3389/fnut.2026.1824771 [doi] LID - 1824771 AB - BACKGROUND: Dietary diversity reflects diet quality and is critical for children's growth and long-term health. Appetitive traits affect dietary habits and long-term food choices. However, few studies have explored the associations between early childhood appetitive traits and dietary diversity in school-age children using standardized and validated tools. METHODS: We recruited 208 kindergarten children aged 5-6 years, with 194 completing the two-year longitudinal follow-up. Appetitive traits were evaluated at age 5-6 using the Child Eating Behavior Questionnaire (CEBQ). Dietary diversity was assessed 2 years later via the Dietary Diversity Score (DDS). Binary logistic regressions were carried out to assess the associations between early childhood appetitive traits and dietary diversity. Inverse probability weighting (IPW) was conducted in complete cases to test the robustness of the main results. RESULTS: Higher food fussiness at 5-6 years was significantly associated with a lower likelihood of high DDS 2 years later (OR = 0.521, 95% CI: 0.327-0.830). No significant sex interactions were observed for these associations. CONCLUSION: Food fussiness at 5-6 years was associated with dietary diversity in school-age children. These findings underscore the relevance of early appetitive traits to dietary diversity and provide evidence-based insights for promoting children's nutrition. CI - Copyright (c) 2026 Mu, Bu, Xu, Yuan, Dai, Lv, Liu, Tang, Zhang and Jin. FAU - Mu, Yuhong AU - Mu Y AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Bu, Duhan AU - Bu D AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Xu, Xiaowen AU - Xu X AD - Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, China. FAU - Yuan, Jing AU - Yuan J AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Dai, Xinxin AU - Dai X AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Lv, Weiqing AU - Lv W AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Liu, Yan AU - Liu Y AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Tang, Jiachen AU - Tang J AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Zhang, Libing AU - Zhang L AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Jin, Yu AU - Jin Y AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. LA - eng PT - Journal Article DEP - 20260721 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13433194 OTO - NOTNLM OT - appetitive traits OT - child eating behavior questionnaire OT - children OT - dietary diversity OT - dietary diversity score COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/07/21 CRDT- 2026/08/05 04:42 PHST- 2026/03/06 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 04:42 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1824771 [doi] PST - epublish SO - Front Nutr. 2026 Jul 21;13:1824771. doi: 10.3389/fnut.2026.1824771. eCollection 2026. PMID- 42552914 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2287-3732 (Print) IS - 2287-3740 (Electronic) IS - 2287-3732 (Linking) VI - 15 IP - 3 DP - 2026 Jul TI - Discrepancies between preschoolers' self-perceived healthy eating practices and parental assessments: a cross-sectional study in South Korea. PG - 184-190 LID - 10.7762/cnr.2026.0009 [doi] AB - OBJECTIVE: Although healthy dietary habits established in early childhood are critical for lifelong health, most previous studies have relied predominantly on parental proxy reports rather than children's self-perceptions. This study compared preschoolers' self-perceived healthy dietary practices with their parents' evaluations and examined discrepancies between them. METHODS: This study included 243 preschoolers aged 2 to 7 years and their parents, recruited from daycare centers in Cheonan, South Korea. Data were collected using the validated, structured, self-administered Healthy Eating Practice Questionnaire, which assessed nutrition and hygiene. Mean Healthy Eating Practice Scores were compared between preschoolers and their parents using paired t-tests, and stratified analyses were conducted by sex and age. RESULTS: Preschoolers rated their healthy dietary practices significantly higher than their parents did (P<0.001). The discrepancy was greater for nutrition than for hygiene, with hygiene ratings more consistent. This domain-specific pattern was consistent across sexes and age groups. When stratified by sex and age, preschooler-parent Healthy Eating Practice Score differences were significantly higher in boys than in girls (25.0+/-21.0 vs. 20.0+/-14.9, respectively; P=0.035). CONCLUSION: Discrepancies between preschoolers' self-perceptions and their parents' evaluations suggest that incorporating both perspectives is essential for accurately assessing children's dietary practices. These findings support the development of dual-perspective dietary assessment and education strategies in early childhood. FAU - An, Jiwon AU - An J AD - Department of Food Science and Nutrition, Dankook University, Cheonan, Korea. FAU - Lee, Seulgi AU - Lee S AD - Department of Food Science and Nutrition, Dankook University, Cheonan, Korea. FAU - Kim, Kirang AU - Kim K AD - Department of Food Science and Nutrition, Dankook University, Cheonan, Korea. LA - eng PT - Journal Article DEP - 20260731 PL - Korea (South) TA - Clin Nutr Res JT - Clinical nutrition research JID - 101592483 PMC - PMC13447742 OTO - NOTNLM OT - Eating behavior OT - Parents OT - Perception OT - Preschool COIS- Conflict of Interest None. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/07/31 CRDT- 2026/08/05 03:35 PHST- 2026/03/11 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 03:35 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - cnr.2026.0009 [pii] AID - cnr-2026-0009 [pii] AID - 10.7762/cnr.2026.0009 [doi] PST - ppublish SO - Clin Nutr Res. 2026 Jul;15(3):184-190. doi: 10.7762/cnr.2026.0009. Epub 2026 Jul 31. PMID- 42552546 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260927 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Aug 4 TI - tVNS and obesity-related inflammation: a prospective sham-controlled randomized crossover study protocol. LID - 10.1186/s40359-026-05219-5 [doi] LID - 1133 AB - BACKGROUND: Overweight and obesity are characterized by detrimental effects on energy metabolism and an increase in adipose tissue, leading to chronic low-grade inflammation. This metaflammation may contribute to mental symptoms, such as reduced mood and motivation. Inflammatory processes are modulated by the cholinergic anti-inflammatory pathway (CAIP) that can be targeted with vagus nerve stimulation (VNS). However, the effects of non-invasive transcutaneous VNS (tVNS) on inflammation have predominantly been investigated in small feasibility studies in humans. Whereas acute anti-inflammatory effects of tVNS have been reported, no study has investigated the effect of daily home-based application on obesity-related metaflammation to date. METHODS: To assess tVNS-induced effects on inflammation, motivation, and mood, we are conducting a single-blind, randomized crossover study in participants with an elevated BMI (target N = 60, 27-35 kg/m(2), 18-40 y). Participants will self-administer high- (active) and low-intensity (sham) stimulation daily (>/= 30 min) for ~ 14 days each (>/= 7 d washout). We will assess peripheral (cytokine levels, circulating immune cells) and central (diffusion weighted imaging) inflammation, motivation (using an effort allocation task during functional MRI), and mood at baseline and after each stimulation phase. During each stimulation phase, participants will complete daily ecological momentary assessments of mood and food choices. We will use mixed-effects models to evaluate differences in slopes of high- vs. low-intensity tVNS. DISCUSSION: This study uses a 14-day home-based tVNS protocol (>/= 30 min daily) accompanied by daily ecologocial momentary assessments to investigate mid-term effects on chronic low-grade inflammation, mood, and motivation. The multimodal study design including a comprehensive panel of peripheral and central inflammatory markers enables the integration of inflammatory and behavioral outcomes and will provide important evidence regarding the efficacy of tVNS in chronic inflammation, based on a study with sufficient statistical power. In addition, the study could provide pathophysiological insights into the link between obesity and symptoms of depression via inflammatory processes. Ultimately, the study will facilitate future research on vagus nerve stimulation to complement the current set of therapies in overweight and obesity. TRIAL REGISTRATION: The study has been preregistered at ClinicalTrials.gov ( https://clinicaltrials.gov/study/NCT06954844 ) on March 21, 2025, Version 1. CI - (c) 2026. The Author(s). FAU - Kaluza, Luisa AU - Kaluza L AUID- ORCID: 0009-0006-1450-0163 AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. AD - Department of Neuroimmunology and Neuromuscular Diseases, Centre for Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany. FAU - Kuhnel, Anne AU - Kuhnel A AUID- ORCID: 0000-0003-3066-3801 AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. AD - German Center for Mental Health (DZPG), partner site Tubingen, Tubingen, Germany. FAU - Picon-Galindo, Ernesto AU - Picon-Galindo E AUID- ORCID: 0000-0001-7174-6561 AD - Institute of Innate Immunity, Biophysical Imaging, University Hospital Bonn, University of Bonn, Bonn, Germany. FAU - Hergenrother, Mona AU - Hergenrother M AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. FAU - Alkhateeb, Hesham AU - Alkhateeb H AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. FAU - Michalski, Simon AU - Michalski S AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. FAU - Ribeiro, Dalila Juliana Silva AU - Ribeiro DJS AD - Institute of Innate Immunity, Biophysical Imaging, University Hospital Bonn, University of Bonn, Bonn, Germany. FAU - Schmidt, Susanne V AU - Schmidt SV AD - Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, 53127, Germany. FAU - Wachten, Dagmar AU - Wachten D AUID- ORCID: 0000-0003-4800-6332 AD - Institute of Innate Immunity, Biophysical Imaging, University Hospital Bonn, University of Bonn, Bonn, Germany. FAU - Kroemer, Nils B AU - Kroemer NB AUID- ORCID: 0000-0002-9552-3781 AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. nkroemer@uni-bonn.de. AD - Department of Psychiatry and Psychotherapy, Tubingen Center for Mental Health, University of Tubingen, Tubingen, Germany. nkroemer@uni-bonn.de. AD - German Center for Mental Health (DZPG), partner site Tubingen, Tubingen, Germany. nkroemer@uni-bonn.de. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. nkroemer@uni-bonn.de. LA - eng SI - ClinicalTrials.gov/NCT06954844 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260804 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 RN - 0 (Cytokines) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - Affect MH - Cross-Over Studies MH - Cytokines/blood MH - *Inflammation/therapy/etiology MH - Motivation MH - *Obesity/complications/therapy MH - Prospective Studies MH - Single-Blind Method MH - *Vagus Nerve Stimulation/methods MH - Randomized Controlled Trials as Topic PMC - PMC13435442 OTO - NOTNLM OT - Effort OT - Metaflammation OT - Motivation OT - Overweight OT - Vagus nerve stimulation COIS- Declarations. Ethics approval and consent to participate: The study was approved by the ethics committee of the Medical Faculty at the University of Bonn (327/23-EP) prior to participant recruitment. All procedures are conducted in accordance with the Declaration of Helsinki. Prior to participation, all individuals provide written informed consent after being given sufficient time for consideration and the opportunity to ask questions to the study team. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/08/04 CRDT- 2026/08/05 00:28 PHST- 2026/07/11 00:00 [received] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 00:28 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.1186/s40359-026-05219-5 [pii] AID - 5219 [pii] AID - 10.1186/s40359-026-05219-5 [doi] PST - epublish SO - BMC Psychol. 2026 Aug 4;14(1):1133. doi: 10.1186/s40359-026-05219-5. PMID- 42552509 OWN - NLM STAT- Publisher LR - 20260805 IS - 1179-2035 (Electronic) IS - 0112-1642 (Linking) DP - 2026 Aug 4 TI - Diagnostic and Prognostic Accuracy of Cardiorespiratory Fitness for Detecting Cardiovascular Risk and Mitochondrial Disorders: An Overview of Systematic Reviews with Meta-Analyses. LID - 10.1007/s40279-026-02503-7 [doi] AB - BACKGROUND: Cardiorespiratory fitness (CRF) is a powerful predictor of current and future health across all age groups. Recognising CRF's ability to screen health-related outcomes is essential for supporting its use in clinical practice. OBJECTIVE: The aim was to evaluate the health-related diagnostic and prognostic accuracy of CRF using an overview of systematic reviews. METHODS: Five bibliographic databases (MEDLINE, Embase, Scopus, CINAHL and SPORTDiscus) were searched from January 2002 to April 2025 to identify systematic reviews with meta-analyses that reported on the health-related diagnostic and prognostic accuracy of CRF. The results were presented using forest plots, with the certainty of evidence assessed by a modified Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach. RESULTS: Of the 10,796 papers identified, six systematic reviews with meta-analyses (n = 31,171 observations) were included. Of these, five examined cardiovascular disease, events, or risk, and one examined mitochondrial disorders. CRF was measured objectively or estimated by exercise as maximum or peak oxygen consumption, ventilatory efficiency or fluctuation, or exercise performance or tolerance. All included reviews were graded as having low to critically low quality. CRF demonstrated high prognostic accuracy for predicting severe cardiovascular events in adults with heart failure, with moderate certainty (diagnostic odds ratio [dOR] 4.1-8.1; area under the curve of a summary receiver operating characteristic curve [SROC AUC] 0.73-0.77), and moderate-to-high diagnostic accuracy for detecting coronary artery disease in adults with type 2 diabetes or with suspected coronary artery disease with very low certainty (dOR 2.3-7.6; SROC AUC 0.66-0.79), mitochondrial disorders among adults with high certainty (dOR 18.1-26.6; SROC AUC 0.70-0.83), and cardiovascular disease risk among apparently healthy children and adolescents with low certainty (dOR 3.6-5.7; SROC AUC 0.64-0.71). CONCLUSIONS: CRF detects cardiovascular disease and mitochondrial disorders and predicts cardiovascular events among adults with chronic conditions and detects cardiovascular risk among apparently healthy children; however, the certainty of evidence ranged from very low to high certainty due to methodological limitations. Further research is needed to generate high-quality diagnostic evidence for CRF across diverse health outcomes and age groups in the general population. TRIAL REGISTRATION: PROSPERO CRD42022370149. CI - (c) 2026. The Author(s). FAU - Fraser, Brooklyn J AU - Fraser BJ AUID- ORCID: 0000-0002-1752-5431 AD - Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7001, Australia. brooklyn.fraser@utas.edu.au. AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. brooklyn.fraser@utas.edu.au. FAU - Gower, Bethany AU - Gower B AUID- ORCID: 0000-0001-6969-6913 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. FAU - Stanesby, Oliver AU - Stanesby O AUID- ORCID: 0000-0002-5996-5881 AD - Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7001, Australia. AD - Baker Heart and Diabetes Institute, Melbourne, VIC, Australia. FAU - Magnussen, Costan G AU - Magnussen CG AUID- ORCID: 0000-0002-6238-5730 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. FAU - Cadenas-Sanchez, Cristina AU - Cadenas-Sanchez C AUID- ORCID: 0000-0002-4513-9108 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - Department of Cardiology, Stanford University, Stanford, CA, USA. AD - Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Granada, Spain. FAU - Chaput, Jean-Philippe AU - Chaput JP AUID- ORCID: 0000-0002-5607-5736 AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. FAU - Manyanga, Taru AU - Manyanga T AUID- ORCID: 0000-0001-5461-5981 AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Division of Medical Sciences, University of Northern British Columbia, Prince George, BC, Canada. FAU - McGrath, Ryan AU - McGrath R AUID- ORCID: 0000-0002-0644-5524 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. AD - Healthy Aging North Dakota (HAND), North Dakota State University, Fargo, ND, USA. AD - Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA. AD - Fargo VA Healthcare System, Fargo, ND, USA. AD - Department of Geriatrics, University of North Dakota, Grand Forks, ND, USA. FAU - Merucci, Katherine AU - Merucci K AUID- ORCID: 0000-0003-1981-7013 AD - Health Library, Health Canada, Ottawa, ON, Canada. FAU - Myers, Jonathan AU - Myers J AUID- ORCID: 0000-0003-2592-136X AD - Department of Cardiology, Stanford University, Stanford, CA, USA. AD - Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. FAU - Ortega, Francisco B AU - Ortega FB AUID- ORCID: 0000-0003-2001-1121 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Granada, Spain. AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Singh, Ben AU - Singh B AUID- ORCID: 0000-0002-7227-2406 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. FAU - Prince, Stephanie A AU - Prince SA AUID- ORCID: 0000-0001-6729-5649 AD - Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, ON, Canada. AD - School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. FAU - Lang, Justin J AU - Lang JJ AUID- ORCID: 0000-0002-1768-319X AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, ON, Canada. AD - School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. FAU - Tomkinson, Grant R AU - Tomkinson GR AUID- ORCID: 0000-0001-7601-9670 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. LA - eng GR - 106588/National Heart Foundation of Australia/ GR - PID2023-148404OB-I00/MICIU/AEI /10.13039/501100011033 and ERDF funds, EU/ GR - 101028929/European Union's Horizon 2020/ PT - Journal Article PT - Systematic Review DEP - 20260804 PL - New Zealand TA - Sports Med JT - Sports medicine (Auckland, N.Z.) JID - 8412297 SB - IM COIS- Declarations. Conflict of interest/Competing interests: The authors declare no conflicts of interest. Funding: No funding was provided for this study. BJF is supported by a National Heart Foundation of Australia Postdoctoral Fellowship (106588). FBO's research activity is supported by the Grant PID2023-148404OB-I00 funded by MICIU/AEI/ https://doi.org/10.13039/501100011033 and ERDF funds, EU. CC-S is supported by a grant from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska Curie grant agreement No 101028929. Availability of data, code, and other materials: All materials from this study have been included as Electronic Supplementary Material. Additional materials are available upon request. Disclaimer: The content and views expressed in this article are those of the authors and do not necessarily reflect those of the Government of Canada. Authors' contributions: BJF screened the records, extracted the data, assessed the methodological quality of each systematic review, took responsibility for the integrity of the data, synthesised the results, and co-wrote the manuscript. BG screened the records, assessed the certainty of evidence, synthesised the results, and co-wrote the manuscript. OS extracted the data, assessed the methodological quality of each systematic review, and critically reviewed the manuscript for important intellectual content. CC-S, JPC, TM, and BS screened the records, contributed to the interpretation of results, and critically reviewed the manuscript for important intellectual content. CGM, JM, RM, and FBO contributed to the interpretation of results and critically reviewed the manuscript for important intellectual content. KM designed and executed the systematic search strategy and critically reviewed the manuscript for important intellectual content. SAP and JJL developed the research question, designed the systematic review, screened the records, contributed to the interpretation of results, and critically reviewed the manuscript for important intellectual content. GRT developed the research question, designed the systematic review, screened the records, had full access to the data, synthesised the results, and co-wrote the manuscript. All authors read and approved the final version of the manuscript. Ethics approval: Not applicable. Consent to participate: Not applicable. Consent for publication: Not applicable. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:42 CRDT- 2026/08/05 00:17 PHST- 2026/07/11 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 00:17 [entrez] AID - 10.1007/s40279-026-02503-7 [pii] AID - 10.1007/s40279-026-02503-7 [doi] PST - aheadofprint SO - Sports Med. 2026 Aug 4. doi: 10.1007/s40279-026-02503-7. PMID- 42550031 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1520-6300 (Electronic) IS - 1042-0533 (Print) IS - 1042-0533 (Linking) VI - 38 IP - 8 DP - 2026 Aug TI - Associations Between Motor Competence, Health-Related Physical Fitness, and Mental Health Outcomes in Spanish Adolescents: The ENERGYCO Study. PG - e70318 LID - 10.1002/ajhb.70318 [doi] LID - e70318 AB - BACKGROUND: Motor competence (MC) has been proposed as an important correlate of physical and mental health during youth. However, evidence examining its associations with both health-related physical fitness and mental health in Spanish adolescents remains limited. OBJECTIVE: To examine the associations between objectively assessed MC and health-related physical fitness and mental health in Spanish adolescents. METHODS: This cross-sectional study included 273 adolescents (46.9% girls; 12-17 years). MC was assessed using the Bruininks-Oseretsky Test of Motor Proficiency Short Form (BOT-2 SF). Anthropometric measures, physical fitness, and mental health were assessed using validated protocols and questionnaires. Two-level linear mixed-effects and generalized estimating equation logistic regression models were adjusted for sex, biological maturation, socioeconomic status, and self-reported physical activity. RESULTS: Higher MC was consistently associated with more favorable health-related physical fitness outcomes (all p < 0.001) and with a greater likelihood of meeting established health-related physical fitness criteria. MC was inversely associated with waist-to-height ratio (p = 0.028), whereas no consistent associations were observed with other anthropometric measures or mental health outcomes. CONCLUSION: Higher MC was consistently associated with health-related physical fitness in Spanish adolescents, whereas associations with anthropometric measures and mental health were limited. Future adequately powered longitudinal and intervention studies are warranted to clarify the directionality of these relationships. CI - (c) 2026 Wiley Periodicals LLC. FAU - Valle-Munoz, Victor Manuel AU - Valle-Munoz VM AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Avila-Garcia, Manuel AU - Avila-Garcia M AD - Inmaculada Teacher Training Centre, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - Faculty of Sport Sciences, Universidad Isabel I, Burgos, Spain. FAU - Campos-Garzon, Pablo AU - Campos-Garzon P AD - SPORT Research Group (CTS-1024), CIBIS (Centro de Investigacion Para el Bienestar y la Inclusion Social) Research Center, University of Almeria, Almeria, Spain. AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. FAU - Perez De Arrilucea Le Floc'h, Unai A AU - Perez De Arrilucea Le Floc'h UA AD - Faculty of Sport Sciences, Universidad Isabel I, Burgos, Spain. AD - Faculty of Health Sciences, Universidad Europea de Valencia, Valencia, Spain. FAU - Estevan, Isaac AU - Estevan I AD - AFIPS Research Group, Department of Teaching of Physical Education, Arts and Music, University of Valencia, Valencia, Spain. FAU - Villa-Gonzalez, Emilio AU - Villa-Gonzalez E AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. LA - eng GR - FPU23/01608/V.M.V.-M.: FPU Predoctoral Research Fellowship from the Spanish Ministry of Universities/ GR - PID2021-126126OA-I00/Spanish Ministry of Science and Innovation (MCIN) and the State Research Agency/ GR - BG24/00004/P.C.-G.: Spanish Ministry of Universities/ GR - PRX24/00031/I.-E.: Spanish Ministry of Science, Innovation and Universities (Gobierno de Espana)/ PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - *Physical Fitness MH - Spain MH - Female MH - *Mental Health/statistics & numerical data MH - Cross-Sectional Studies MH - Adolescent MH - *Motor Skills MH - Male MH - Child PMC - PMC13436258 OTO - NOTNLM OT - adolescence OT - gross motor skills OT - health OT - physical education COIS- The authors declare no conflicts of interest. EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/08/04 CRDT- 2026/08/04 10:03 PHST- 2026/07/01 00:00 [revised] PHST- 2026/04/10 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 10:03 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - AJHB70318 [pii] AID - 10.1002/ajhb.70318 [doi] PST - ppublish SO - Am J Hum Biol. 2026 Aug;38(8):e70318. doi: 10.1002/ajhb.70318. PMID- 42549732 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1552-695X (Electronic) IS - 1534-7354 (Print) IS - 1534-7354 (Linking) VI - 25 DP - 2026 Jan-Dec TI - Caregiver's Kitchen: A Mixed Methods Feasibility Study of a Culinary Medicine and Coaching Intervention for Caregivers of Children With Cancer. PG - 15347354261476641 LID - 10.1177/15347354261476641 [doi] LID - 15347354261476641 AB - Caregivers play a central role in managing the nutrition challenges that arise during pediatric cancer treatment, yet many report insufficient knowledge, low confidence, and limited support for preparing foods that address treatment-related side effects. Culinary medicine, integrating nutrition education with hands-on cooking, may help caregivers navigate these challenges, but caregiver-centered programs in pediatric oncology are scarce. Caregiver's Kitchen is an eight-week, remotely delivered culinary medicine and coaching intervention designed to strengthen caregiver nutrition knowledge, cooking skills, and confidence in managing their child's symptoms. This mixed-methods feasibility study evaluated program feasibility and acceptability and explored caregiver experiences to inform refinement of a future trial. Ten caregiver-child dyads were enrolled. Caregivers participated in four live virtual culinary workshops and four individualized telephone coaching sessions. Feasibility outcomes included recruitment, retention, assessment completion, engagement, and acceptability, assessed against predefined progression criteria. Qualitative feedback was collected through post-intervention open-ended survey questions and analyzed using rapid content analysis. Three of five feasibility criteria were met. Recruitment targets were achieved (2-3 dyads/week), and engagement was high, with 80% attending >/=3 workshops and 90% completing >/=2 coaching calls. Acceptability was strong (mean ratings 4.35/5). Assessment completion declined at later time points. Qualitative findings highlighted the usefulness of practical culinary guidance, accessible recipes, and individualized coaching, while identifying scheduling constraints and lengthy assessments as barriers. Caregiver insights informed refinements to enhance feasibility, including transitioning to self-paced modules and streamlining assessments. Findings support progression to a larger pilot trial. FAU - Milliron, Brandy-Joe AU - Milliron BJ AUID- ORCID: 0000-0003-1113-9043 AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. RINGGOLD: 15775 FAU - Salman, Khulood AU - Salman K AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. RINGGOLD: 15775 FAU - Schlechter, Haley AU - Schlechter H AD - Children's Hospital of Philadelphia, King of Prussia, PA, USA. RINGGOLD: 6567 FAU - Mountain, Paige AU - Mountain P AD - Department of Clinical Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Longo, Gabrielle AU - Longo G AD - Department of Clinical Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Deutsch, Jonathan M AU - Deutsch JM AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. RINGGOLD: 15775 FAU - Jubelirer, Tracey AU - Jubelirer T AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. AD - Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 LA - eng PT - Journal Article DEP - 20260804 PL - United States TA - Integr Cancer Ther JT - Integrative cancer therapies JID - 101128834 SB - IM MH - Humans MH - *Caregivers/education/psychology MH - Feasibility Studies MH - *Neoplasms MH - Female MH - Male MH - Child MH - *Cooking/methods MH - Adult MH - Mentoring/methods MH - Middle Aged MH - Surveys and Questionnaires MH - Child, Preschool MH - Health Knowledge, Attitudes, Practice PMC - PMC13438338 OTO - NOTNLM OT - caregiving OT - culinary medicine OT - integrative care OT - nutrition OT - pediatric cancer COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/08/04 CRDT- 2026/08/04 07:33 PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 07:33 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.1177_15347354261476641 [pii] AID - 10.1177/15347354261476641 [doi] PST - ppublish SO - Integr Cancer Ther. 2026 Jan-Dec;25:15347354261476641. doi: 10.1177/15347354261476641. Epub 2026 Aug 4. PMID- 42549391 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Artificial intelligence in nutritional health: sustainable consumers' right to quality of life with special reference to youth. PG - 1817284 LID - 10.3389/fpubh.2026.1817284 [doi] LID - 1817284 AB - BACKGROUND: Maintaining optimal youth nutritional health is an urgent socio-economic imperative that underpins long-term human productivity and rights-based development. However, modern youth cohorts face unique dietary threats caused by the widespread availability of ultra-processed foods, targeted digital marketing, and complex food labeling protocols. Although Artificial Intelligence (AI) presents innovative avenues for personalized dietary profiling, existing systems remain largely technocentric and detached from statutory frameworks or behavioral realities. OBJECTIVE: This study bridges this interdisciplinary divide by evaluating a rights-based, technology-driven framework to improve youth nutritional health. It aims to: (1) empirically evaluate the "Knowledge-Attitude-Practice" (KAP) gap linking statutory consumer rights to real-world eating habits; (2) present the engineering design of a non-commercial Progressive Web Application (PWA) built to translate legal safeguards into daily behavioral changes; and (3) triangulate these findings using data from youth surveys and expert legal and nutritional panels. METHODS: Using a cross-sectional approach based on non-parametric power constraints, a validated survey instrument was completed by a target sample of Indian youth (n = 354, aged 15-25 years). Concurrently, data matrices were compiled from regional legal experts (n = 12) and public nutrition professionals (n = 12) to cross-verify structural bottlenecks. Group variances, demographic dependencies, and rank associations were analyzed using robust non-parametric tests, including One-Way ANOVA, Kruskal-Wallis (H), Welch's t-test, and Kendall's Tau (tau) correlation coefficients. RESULTS: Inferential analysis revealed unexpected demographic trends: undergraduate status predicted significantly higher FSSAI safety awareness than post-graduate status (p = 0.0037), while subjective health ratings exhibited a non-linear relationship with household income (p = 0.0004), peaking in the lower-middle financial tier. Crucially, rank correlation testing revealed that the relationship between statutory knowledge and actual dietary actions is functionally non-existent (tau = -0.001). This near-zero correlation provides clear empirical proof of a pronounced Knowledge-Action Gap, confirming that passive legal literacy fails to influence food selection in modern environments. CONCLUSION: By framing automated behavioral interventions within the constitutional protections of Article 21 of the Constitution of India and the Consumer Protection Act, 2019, this study shows how the open-access PWA (nutrition-zb.pages.dev) can bridge this behavioral gap. This shifts the focus of consumer health informatics from basic self-tracking to a rights-based, systemic public health intervention. CI - Copyright (c) 2026 Indirapriyadarsini, Guttapalam, Mogarala and Guptha. FAU - Indirapriyadarsini, G AU - Indirapriyadarsini G AD - Department of Law, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India. FAU - Guttapalam, Sireesha AU - Guttapalam S AD - Department of Home Science, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India. FAU - Mogarala, Ramyasri AU - Mogarala R AD - Department of Research and Development Cell, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India. FAU - Guptha, Kalpeshkumar L AU - Guptha KL AD - Former Faculty, Gujarat National Law University, Surat, Gujarat, India. LA - eng PT - Journal Article DEP - 20260720 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Artificial Intelligence MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - *Quality of Life MH - Adult MH - India MH - *Health Knowledge, Attitudes, Practice MH - *Feeding Behavior MH - Surveys and Questionnaires PMC - PMC13431161 OTO - NOTNLM OT - artificial intelligence OT - consumer protection OT - food safety regulations OT - knowledge-attitude-practice (KAP) gap OT - progressive web application (PWA) OT - sustainable development goals OT - sustainable health OT - youth health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/07/20 CRDT- 2026/08/04 06:34 PHST- 2026/02/25 00:00 [received] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 06:34 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1817284 [doi] PST - epublish SO - Front Public Health. 2026 Jul 20;14:1817284. doi: 10.3389/fpubh.2026.1817284. eCollection 2026. PMID- 42549124 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260804 LR - 20260827 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Correction: Comparison of Chinese and international birth weight standards in predicting early childhood growth outcomes: a retrospective cohort study. PG - 1905752 LID - 10.3389/fped.2026.1905752 [doi] LID - 1905752 AB - [This corrects the article DOI: 10.3389/fped.2026.1810686.]. CI - (c) 2026 Zhang, Zhang, Gao, Li, Zhang, Liu and Li. FAU - Zhang, Ting AU - Zhang T AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Zhang, Zhenyu AU - Zhang Z AD - School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China. FAU - Gao, Mai AU - Gao M AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Li, Ziyun AU - Li Z AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Zhang, Li AU - Zhang L AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Liu, Huijuan AU - Liu H AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Li, Yan AU - Li Y AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. LA - eng PT - Published Erratum DEP - 20260720 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 EFR - Front Pediatr. 2026 Jun 08;14:1810686. doi: 10.3389/fped.2026.1810686. PMID: 42339296 PMC - PMC13430599 OTO - NOTNLM OT - birth weight OT - growth standards OT - possible risk of overweight OT - predictive validity OT - wasting EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/07/20 CRDT- 2026/08/04 06:11 PHST- 2026/06/11 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 06:11 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.3389/fped.2026.1905752 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 20;14:1905752. doi: 10.3389/fped.2026.1905752. eCollection 2026. PMID- 42548891 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260804 LR - 20260813 IS - 2251-6093 (Electronic) IS - 2251-6085 (Print) IS - 2251-6085 (Linking) VI - 54 IP - 12 DP - 2025 Dec TI - Development of a Deep Learning Model for Predicting Obesity Using Health Behavior Data of Elementary School Students. PG - 2690-2700 LID - 10.18502/ijph.v54i12.20821 [doi] AB - BACKGROUND: Childhood obesity poses serious long-term health risks and is a growing global concern. In South Korea, national health surveys collect behavioral and physical data from elementary students, but the large number of questionnaire items can burden young respondents and reduce accuracy. Thus, simplified models with high predictive power are needed. METHODS: We analyzed data from over 250,000 elementary students collected by the Korean Ministry of Education (2015-2022). Using the Rohrer Index as the outcome variable, key predictors were selected via Lasso and Elastic Net regression. Categorical variables were reduced using Multiple Correspondence Analysis (MCA), and a deep learning model (NECTOR) combining MLP and self-attention was developed. RESULTS: NECTOR achieved high predictive performance with R(2) scores of 0.994 (boys) and 0.996 (girls), and low mean squared errors of 3.072 and 1.841, respectively. It outperformed baseline models using the same inputs. CONCLUSION: A small set of core health indicators can effectively predict the Rohrer Index. The proposed model enables efficient and reliable obesity screening in school settings, supporting early intervention efforts. CI - Copyright(c) 2025 Kim et al. Published by Tehran University of Medical Sciences. FAU - Kim, Changgyun AU - Kim C AD - Department of Electronic and AI System Engineering, Kangwon National University, Kangwon, Samcheok, 25913, Republic of Korea. FAU - Lee, Ji-Yong AU - Lee JY AD - Center for Sports and Performance Analysis, Korea National Sports University, Seoul, Songpa-gu, 05541, Republic of Korea. LA - eng PT - Journal Article PL - Iran TA - Iran J Public Health JT - Iranian journal of public health JID - 7505531 PMC - PMC13430117 OTO - NOTNLM OT - Childhood obesity OT - Deep learning OT - Health behavior OT - Rohrer index OT - School health survey EDAT- 2026/08/04 12:30 MHDA- 2026/08/04 06:38 PMCR- 2025/12/01 CRDT- 2026/08/04 05:52 PHST- 2025/04/23 00:00 [received] PHST- 2025/06/28 00:00 [accepted] PHST- 2026/08/04 06:38 [medline] PHST- 2026/08/04 12:30 [pubmed] PHST- 2026/08/04 05:52 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - IJPH-54-2690 [pii] AID - 10.18502/ijph.v54i12.20821 [doi] PST - ppublish SO - Iran J Public Health. 2025 Dec;54(12):2690-2700. doi: 10.18502/ijph.v54i12.20821. PMID- 42548181 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 2092-7193 (Electronic) IS - 2092-7193 (Linking) VI - 48 DP - 2026 TI - Device-related differences in blood pressure measurement and their impact on hypertension prevalence in Korean children and adolescents. PG - e2026037 LID - 10.4178/epih.e2026037 [doi] AB - OBJECTIVES: Accurate blood pressure (BP) measurement is essential for reliably estimating hypertension prevalence in population-based surveys. However, evidence supporting the use of oscillometric BP devices in pediatric populations remains limited. This study compared BP measurements obtained using an oscillometric device (OD) and an auscultatory device (AD) and evaluated inter-device agreement and the impact of device choice on hypertension prevalence estimates. METHODS: BP was measured sequentially with the AD and OD in 251 children and adolescents participating in the Korea National Health and Nutrition Examination Survey. Inter-device agreement was assessed using mean differences, limits of agreement, concordance correlation coefficients (CCCs), and regression analyses. Differences in prevalence estimates for elevated blood pressure (EBP) and hypertension were also examined. RESULTS: Mean inter-device differences were minimal for systolic blood pressure (SBP; 0.2+/-5.9 mmHg) but negative for diastolic blood pressure (DBP; -1.5+/-6.1 mmHg), with larger discrepancies in older girls. Agreement was moderate to good for SBP (CCC=0.79) and weaker for DBP (CCC=0.60). Nevertheless, more than 85% of paired measurements were within +/-10 mmHg. Prevalence estimates for EBP (11.6 vs. 10.0%) and hypertension (4.8 vs. 4.4%) were comparable between devices, with relatively high negative agreement and overall agreement. CONCLUSIONS: Despite modest underestimation of DBP in specific subgroups, oscillometric BP measurement showed acceptable agreement with the auscultatory method and yielded similar hypertension prevalence estimates. These findings suggest that ODs may be useful for pediatric BP measurement in public health surveillance systems. FAU - Kim, Sung Hye AU - Kim SH AD - Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea. FAU - Kim, Yu-Mi AU - Kim YM AD - Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea. AD - Institute for Health and Society, Hanyang University, Seoul, Korea. FAU - Kim, Hack-Lyoung AU - Kim HL AD - Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea. FAU - Park, Sang Min AU - Park SM AD - Division of Cardiology, Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul, Korea. FAU - Cho, In-Jeong AU - Cho IJ AD - Division of Cardiology, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea. FAU - Kim, Dae-Hee AU - Kim DH AD - Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. FAU - Kim, Kwang-Il AU - Kim KI AD - Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. FAU - Shin, Jinho AU - Shin J AD - Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. FAU - Oh, Kyungwon AU - Oh K AD - Division of Health and Nutrition Survey and Analysis, Bureau of Chronic Disease Prevention and Control, Korea Disease Control and Prevention Agency, Cheongju, Korea. FAU - Lee, Eun Mi AU - Lee EM AD - Division of Cardiology, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea. mdemlee@naver.com. LA - eng PT - Journal Article DEP - 20260727 PL - Korea (South) TA - Epidemiol Health JT - Epidemiology and health JID - 101519472 SB - IM MH - Humans MH - Female MH - *Hypertension/epidemiology/diagnosis MH - Adolescent MH - Republic of Korea/epidemiology MH - Male MH - Child MH - *Blood Pressure Determination/instrumentation/methods MH - Prevalence MH - Oscillometry/instrumentation MH - Nutrition Surveys OTO - NOTNLM OT - Adolescent OT - Blood pressure OT - Blood pressure determination OT - Child OT - Hypertension OT - Oscillometry EDAT- 2026/08/04 06:37 MHDA- 2026/10/14 23:31 CRDT- 2026/08/04 03:09 PHST- 2026/04/16 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/10/14 23:31 [medline] PHST- 2026/08/04 06:37 [pubmed] PHST- 2026/08/04 03:09 [entrez] AID - epih.e2026037 [pii] AID - 10.4178/epih.e2026037 [doi] PST - ppublish SO - Epidemiol Health. 2026;48:e2026037. doi: 10.4178/epih.e2026037. Epub 2026 Jul 27. PMID- 42547597 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261026 IS - 1432-5241 (Electronic) IS - 0364-216X (Linking) VI - 50 IP - 19 DP - 2026 Oct TI - The Golden Triangle Method: A Novel Simulation Framework for Rhinoplasty Design. PG - 7905-7919 LID - 10.1007/s00266-026-06197-0 [doi] AB - BACKGROUND: Current rhinoplasty simulation relies on subjective landmark planning and compartmentalized parameter analysis, resulting in inconsistent designs. This study introduces a unified geometric framework to assist in the design of harmonious noses. OBJECTIVES: To develop and provide proof-of-concept validation for a geometric framework that systematically determines optimal nasal landmark positions based on facial proportions, and to evaluate its aesthetic acceptability. METHODS: This prospective study included 30 young Turkish women (aged 18-30 years) seeking primary rhinoplasty, evaluated by 20 board-certified plastic surgeons (17 included in Visual Analog Scales analysis after outlier exclusion) and the patients themselves. The Golden Triangle method employs a 36 degrees -apex isosceles triangle to determine key nasal landmarks within a cohesive geometric framework. Simulations were created using GeoGebra (which also calculated nasal ratios and angles) and Adobe Photoshop. Evaluators rated pre- and post-simulation images using Visual Analog Scales (0-100). Technical parameters were evaluated on 5-point Likert scale by surgeons. RESULTS: Patient VAS scores increased from 41.3 +/- 10.1 to 81.9 +/- 3.3 (p < .001; Cohen's d = 5.41), and surgeon ratings improved from 34.7 +/- 6.3 to 72.6 +/- 4.4 (p < .001; Cohen's d = 7.02). The coefficient of variation decreased by 66.2% for patients' and 53.7% for surgeons' ratings, indicating improved interrater agreement on simulation images. Technical parameters reached "ideal" consensus in 93-97% of cases. Nasal ratios and angles converged toward population-specific reference values with reduced variability. CONCLUSIONS: The Golden Triangle method provides a systematic approach to rhinoplasty simulation, significantly improving aesthetic ratings and interrater agreement using affordable software. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . CI - (c) 2026. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery. FAU - Erbayat, Yusuf AU - Erbayat Y AUID- ORCID: 0000-0003-3253-6494 AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Recep Tayyip Erdogan University Teaching and Research Hospital, Islampasa Mh. Sehitler Cd. No:74 Merkez, Rize, Turkey. erbayaty@gmail.com. FAU - Kirazoglu, Ahmet AU - Kirazoglu A AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Florya Hospital, Istanbul, Turkey. FAU - Yildiz, Kemalettin AU - Yildiz K AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260803 PL - United States TA - Aesthetic Plast Surg JT - Aesthetic plastic surgery JID - 7701756 SB - IM MH - Humans MH - *Rhinoplasty/methods MH - Female MH - Adult MH - Prospective Studies MH - Young Adult MH - Adolescent MH - Esthetics MH - *Nose/anatomy & histology/surgery MH - *Computer Simulation MH - Anatomic Landmarks OTO - NOTNLM OT - Anthropometry OT - Computer simulation OT - Golden Triangle OT - Preoperative planning OT - Rhinoplasty OT - Visual Analog Scale COIS- Declarations. Conflict of interest: The corresponding author has a pending utility model application (Turkish Patent and Trademark Office, Application No: 2026/000080) for the simulation software of the Golden Triangle Method described in this study. All other authors declare that they have no conflicts of interest to disclose. Ethical Approval: This prospective observational study received approval from the University Ethics Committee on March 14, 2024 (Approval No: E-54022451-050.04-144694). All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. Informed Consent: Informed consent was obtained from all individual participants included in the study. EDAT- 2026/08/04 00:35 MHDA- 2026/10/26 17:31 CRDT- 2026/08/03 23:52 PHST- 2026/01/22 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/10/26 17:31 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 23:52 [entrez] AID - 10.1007/s00266-026-06197-0 [pii] AID - 10.1007/s00266-026-06197-0 [doi] PST - ppublish SO - Aesthetic Plast Surg. 2026 Oct;50(19):7905-7919. doi: 10.1007/s00266-026-06197-0. Epub 2026 Aug 3. PMID- 42547504 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260824 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Aug 3 TI - Psychosocial and dietary influences on eating behaviors and body mass index among geographically diverse Indian university students. LID - 10.1038/s41598-026-48491-6 [doi] LID - 23865 AB - In the context of India's growing youth population, the interplay of dietary habits, social influences, and psychological factors critically shapes nutritional health outcomes. This cross-sectional study examined the socio-demographic, dietary, psychological, and social determinants of eating behaviour and their association with body mass index (BMI) among 3,150 undergraduate students from agricultural universities across six Indian regions. Using a validated self-administered questionnaire and anthropometric assessments, the study applied Principal Component Analysis (PCA) on 14 binary behavioural variables to identify latent dimensions influencing dietary patterns. The key behavioral components associated with BMI were: External Cues & Emotional Reactivity (PC2) (beta = +2.04, r = + 0.77), characterized by emotional eating and responsiveness to food advertisements; Dietary Practices & Cultural Disengagement (PC1) (beta = -1.54, r = - 0.58), reflecting structured dietary habits independent of cultural food norms; and Positive Affect & Peer Independence (PC6) (beta = -0.84, r = - 0.31), indicating emotionally positive, peer-independent eating. Dietary assessments revealed that although cereal consumption was adequate (100%), notable deficiencies were observed in the intake of green leafy vegetables, milk, and fruits, with consumption levels falling approximately 31-34%, 13-18%, and 10-20% below recommended dietary guidelines, respectively. The findings highlighted that beyond nutritional deficits, psychosocial factors including emotional reactivity and social pressures significantly influence students' weight status. Emotional vulnerability and environmental cues linked with higher BMI, whereas structured eating and emotional well-being are protective. This research underscores the need for gender and socially sensitive nutrition programs in Indian universities to prevent both obesity and undernutrition. CI - (c) 2026. The Author(s). FAU - Mahra, Girijesh Singh AU - Mahra GS AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. girijeshmahra22@gmail.com. FAU - Joshi, Pratibha AU - Joshi P AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. pratijosh12@gmail.com. FAU - Satyapriya AU - Satyapriya AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. satya118ext@gmail.com. FAU - Bishnoi, Sitaram AU - Bishnoi S AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. srext2011@gmail.com. FAU - Sahu, Subhashree AU - Sahu S AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. FAU - Barua, Sukanya AU - Barua S AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. FAU - Burman, Rajarshi Roy AU - Burman RR AD - Division of Agricultural Extension, Indian Council of Agricultural Research, New Delhi, India. LA - eng PT - Journal Article DEP - 20260803 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - *Feeding Behavior/psychology MH - India MH - *Body Mass Index MH - Universities MH - Cross-Sectional Studies MH - Young Adult MH - *Diet MH - Adolescent MH - Emotional Eating MH - Adult MH - Surveys and Questionnaires PMC - PMC13434682 OTO - NOTNLM OT - Consumption pattern OT - Demographic dividend OT - Dietary habits OT - Social and psychological factors COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: All methods used in this study were conducted in accordance with the relevant guidelines and regulations. The study received approval from the Research Ethics Committee of the Division of Agricultural Extension, ICAR-Indian Agricultural Research Institute, New Delhi, India (Approval No. Ag Extn/2025/579(A), Date: 01 January, 2025). Informed consent was obtained from each participant, and their confidentiality was ensured throughout the study. EDAT- 2026/08/04 00:35 MHDA- 2026/08/04 00:36 PMCR- 2026/08/03 CRDT- 2026/08/03 23:18 PHST- 2025/07/29 00:00 [received] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/08/04 00:36 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 23:18 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.1038/s41598-026-48491-6 [pii] AID - 48491 [pii] AID - 10.1038/s41598-026-48491-6 [doi] PST - epublish SO - Sci Rep. 2026 Aug 3;16(1):23865. doi: 10.1038/s41598-026-48491-6. PMID- 42547409 OWN - NLM STAT- Publisher LR - 20260803 IS - 1941-2444 (Electronic) IS - 0148-6071 (Linking) DP - 2026 Aug 3 TI - Nutritional and environmental determinants of maturation and disruption of the early life gut microbiome: A narrative review. LID - 10.1002/jpen.70127 [doi] AB - The first 1000 days of life represent a critical window for gut microbiome assembly, with lifelong implications for child growth, immune development, and disease risk. This review synthesizes evidence on maternal, perinatal, and especially nutritional factors that influence early-life intestinal colonization and highlights the consequences of microbial disruptions during this period. In utero exposures and birth-associated factors can profoundly shape microbial development, reducing diversity and beneficial taxa. Nutrition exerts a particularly dominant and modifiable influence: breastfeeding supports Bifidobacterium-rich communities, while formula use and early complementary feeding shape microbiota diversity and metabolic function. Dietary quality, fiber intake, and food diversity are key determinants of microbial maturation and resilience. Undernutrition and inadequate diets contribute to microbial dysbiosis, creating a self-reinforcing cycle of malabsorption, growth failure, and long-term metabolic consequences. Early microbial perturbations are associated with a range of acute and chronic diseases, including necrotizing enterocolitis, obesity, type 1 diabetes, inflammatory bowel disease, and atopic disorders. Strategies to restore microbial balance require further validation, particularly in nutritionally vulnerable populations. The absence of a universal definition for a "healthy" pediatric microbiome limits the development of targeted interventions. Emerging metrics, such as microbiota-for-age z-scores and functional microbiome profiling, may help define microbiota maturity and therapeutic efficacy. CI - (c) 2026 The Author(s). Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. FAU - Burow, Carly AU - Burow C AUID- ORCID: 0000-0002-2033-672X AD - Faculty of Science, McMaster University, Hamilton, Ontario, Canada. AD - Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada. FAU - Shenderey, Romy AU - Shenderey R AD - Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada. AD - Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. FAU - Chowdhury, Fariha AU - Chowdhury F AUID- ORCID: 0000-0002-9760-186X AD - Faculty of Science, McMaster University, Hamilton, Ontario, Canada. FAU - Shah, Nyah AU - Shah N AD - Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada. AD - Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. FAU - Pai, Nikhil AU - Pai N AUID- ORCID: 0000-0002-7537-6059 AD - Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. AD - Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. LA - eng PT - Journal Article PT - Review DEP - 20260803 PL - United States TA - JPEN J Parenter Enteral Nutr JT - JPEN. Journal of parenteral and enteral nutrition JID - 7804134 SB - IM OTO - NOTNLM OT - life cycle OT - microbiome OT - nutrition OT - pediatrics OT - research and diseases EDAT- 2026/08/04 00:35 MHDA- 2026/08/04 00:35 CRDT- 2026/08/03 22:02 PHST- 2026/06/16 00:00 [revised] PHST- 2025/11/17 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 22:02 [entrez] AID - 10.1002/jpen.70127 [doi] PST - aheadofprint SO - JPEN J Parenter Enteral Nutr. 2026 Aug 3. doi: 10.1002/jpen.70127. PMID- 42545817 OWN - NLM STAT- Publisher LR - 20260803 IS - 1950-6945 (Electronic) IS - 1294-9361 (Linking) DP - 2026 Aug 3 TI - Dietary patterns in children with epilepsy: The role of household environment and clinical comorbidities. LID - 10.1002/epd2.70362 [doi] AB - OBJECTIVE: To evaluate dietary patterns in children with epilepsy and compare them with age- and sex-matched healthy siblings living in the same household environment. Associations between clinical characteristics and dietary adequacy were also examined. METHODS: This cross-sectional study included 58 participants (37 with epilepsy and 21 sibling controls), aged 2-18 years, recruited from a tertiary epilepsy clinic. Dietary intake was assessed using validated, age-specific food frequency questionnaires and classified according to national recommendations. Regression models were used to identify predictors of dietary intake and adequacy. RESULTS: Both groups exhibited inadequate consumption of cereals, fruits, and vegetables, and excessive intake of sugary and ultra-processed foods. No significant differences in dietary intake or adequacy were found between children with epilepsy and their siblings. Within the epilepsy group, motor impairment, and constipation were associated with higher vegetable intake. Conversely, intellectual disability and developmental delay were linked to lower vegetable and fruit intake respectively. Autism spectrum disorder decreased the odds of inadequate vegetable intake, while intellectual disability and younger age increased it. SIGNIFICANCE: Children and adolescents with epilepsy exhibited similar dietary patterns to their healthy siblings, while within the epilepsy group, clinical characteristics, and comorbidities were associated with significant variations in dietary intake and adequacy. These findings suggest that nutritional counseling in pediatric epilepsy should be tailored to clinical comorbidities and family context rather than epilepsy diagnosis alone. CI - (c) 2026 The Author(s). Epileptic Disorders published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. FAU - Oliveira, Ana Claudia Candido AU - Oliveira ACC AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. FAU - Santana, Maria Eduarda Pereira AU - Santana MEP AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. FAU - Zanin, Giuliane V M AU - Zanin GVM AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. FAU - da Silva, Jaqueline Lamas AU - da Silva JL AUID- ORCID: 0009-0007-5482-141X AD - Department of Statistics, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil. FAU - Zeller, Camila Borelli AU - Zeller CB AUID- ORCID: 0000-0002-1042-7425 AD - Department of Statistics, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil. FAU - Coan, Ana Carolina AU - Coan AC AUID- ORCID: 0000-0002-2888-929X AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. AD - Brazilian Institute of Neuroscience and Neurotechnology, BRAINN at UNICAMP, Campinas, SP, Brazil. AD - Neuroimaging Laboratory, UNICAMP, Campinas, SP, Brazil. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20260803 PL - United States TA - Epileptic Disord JT - Epileptic disorders : international epilepsy journal with videotape JID - 100891853 SB - IM OTO - NOTNLM OT - children OT - diet OT - epilepsy OT - food frequency questionnaire OT - nutritional adequacy EDAT- 2026/08/03 18:37 MHDA- 2026/08/03 18:37 CRDT- 2026/08/03 12:38 PHST- 2026/07/09 00:00 [revised] PHST- 2026/02/13 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/03 18:37 [medline] PHST- 2026/08/03 18:37 [pubmed] PHST- 2026/08/03 12:38 [entrez] AID - 10.1002/epd2.70362 [doi] PST - aheadofprint SO - Epileptic Disord. 2026 Aug 3. doi: 10.1002/epd2.70362. PMID- 42545433 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260813 IS - 1437-9813 (Electronic) IS - 0179-0358 (Print) IS - 0179-0358 (Linking) VI - 42 IP - 1 DP - 2026 Aug 3 TI - Impact of an unrestricted clear liquid fasting protocol on pediatric perioperative outcomes: a prospective interventional study. LID - 10.1007/s00383-026-06558-5 [doi] LID - 328 AB - PURPOSE: Traditional preoperative fasting guidance (6-4-2) aims to reduce aspiration risk but frequently produces prolonged fasting and discomfort in children. We evaluated whether progressively liberalizing the clear-liquid fasting policy reduces fasting time and improves the perioperative experience. METHODS: We conducted a prospective, four-phase interventional quality-improvement study at a tertiary hospital in rural Kenya (11/2021-12/2022). Phase 0 followed standard 6-4-2 guidelines; Phase 1 shortened clear-liquid fasting to 1 h; Phase 2 permitted a fixed volume of water until transfer to theatre; Phase 3, unrestricted water. The primary outcome was clear-liquid fasting time. Secondary outcomes were thirst, hunger, parental satisfaction, preoperative anxiety, and aspiration events. RESULTS: Among 253 children, median clear-liquid fasting time decreased: 14.0 h (Phase 0) to 1.7 h (Phase 3) (p < 0.001). Anxiety decreased significantly (mYPAS 35.4 to 22.9; p < 0.001) and thirst declined. Parental satisfaction was higher but did not reach statistical significance (8.0 to 9.0; p = 0.06). One confirmed aspiration occurred in Phase 1 (7.2-h fasting time). CONCLUSION: Reducing preoperative fasting improved comfort and lowered anxiety. No increase in clinically significant aspiration events was observed, although the study was not powered for rare events. An unrestricted clear-liquid protocol appears feasible and beneficial. CI - (c) 2026. The Author(s). FAU - Mina, Alexander S AU - Mina AS AUID- ORCID: 0000-0002-9815-917X AD - Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA. alexander.mina@bcm.edu. FAU - Gomez, Dimingo AU - Gomez D AD - Division of Pediatric Surgery, AIC Kijabe Hospital, 00220, Kijabe, Kenya. FAU - Nguyen, Duc T AU - Nguyen DT AD - Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA. FAU - Kynes, J Matthew AU - Kynes JM AD - Division of Pediatric Surgery, AIC Kijabe Hospital, 00220, Kijabe, Kenya. FAU - Axt, Jason AU - Axt J AD - Division of Pediatric Surgery, AIC Kijabe Hospital, 00220, Kijabe, Kenya. LA - eng PT - Journal Article DEP - 20260803 PL - Germany TA - Pediatr Surg Int JT - Pediatric surgery international JID - 8609169 SB - IM MH - Humans MH - *Fasting MH - Prospective Studies MH - Female MH - Male MH - *Preoperative Care/methods MH - Child, Preschool MH - Child MH - Infant MH - Quality Improvement MH - Anxiety/prevention & control MH - Kenya MH - Patient Satisfaction PMC - PMC13433598 OTO - NOTNLM OT - Clear liquids OT - Patient satisfaction OT - Pediatric surgery OT - Preoperative fasting OT - Quality improvement COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the AIC Kijabe Hospital Institutional Scientific and Ethics Review Committee. Consent to participate: Written informed consent was obtained from the parents or legal guardians of all children included in the study. Consent to publish: Not applicable; the manuscript contains no individually identifiable information. EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:43 PMCR- 2026/08/03 CRDT- 2026/08/03 11:06 PHST- 2026/05/25 00:00 [received] PHST- 2026/07/26 00:00 [accepted] PHST- 2026/08/03 12:43 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 11:06 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.1007/s00383-026-06558-5 [pii] AID - 6558 [pii] AID - 10.1007/s00383-026-06558-5 [doi] PST - epublish SO - Pediatr Surg Int. 2026 Aug 3;42(1):328. doi: 10.1007/s00383-026-06558-5. PMID- 42545147 OWN - NLM STAT- Publisher LR - 20260803 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Aug 3 TI - Maternal and newborn health in vegan and omnivore pregnancies: A prospective pilot study (PREGGIE). PG - 2601060261474598 LID - 10.1177/02601060261474598 [doi] AB - BackgroundFew studies have assessed health outcomes in pregnant vegans and their newborns.AimThis study aimed to examine this evidence gap.MethodsThis pilot study compared health parameters of pregnant vegans (n = 32) and omnivores (n = 13), as well as their newborns, in Germany (2019-2022). Maternal body mass index, weight and blood pressure were measured at gestational weeks 9-16 (t1) and 35-38 (t2). Additional assessments included maternal weight gain and excessive weight gain (from the beginning of pregnancy to t2), delivery method, gestational age, preterm birth, sex ratio, birth weight and length, small/large for gestational age, low birth weight, macrosomia, head circumference, and Apgar scores.SummaryNo significant differences were observed between the vegan and omnivore groups for any newborn outcomes, birth characteristics, or maternal health parameters. No preterm births occurred. Small for gestational age was observed in 2 vegan (6%) and 3 omnivore newborns (23%). Low birth weight (<2500 g) occurred in 1 vegan newborn (3%) and in no omnivore newborns. An Apgar score <10 at 10 min was recorded in 1 vegan (3%) and 1 (8%) omnivore newborn (both scoring 8).This study detected no clear adverse effects of a supplemented vegan diet (vitamin B12, iodine, vitamin D, omega-3 fatty acids) during pregnancy. Differences between vegans and omnivores cannot be excluded. The study was underpowered and baseline differences limit group comparability, validity, and generalizability. The study highlights key parameters and underscores the need to maximize group comparability in future research. FAU - Koeder, Christian AU - Koeder C AUID- ORCID: 0000-0002-3761-4220 AD - Institute for Prevention and Cancer Epidemiology (IPE), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. RINGGOLD: 14879 AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. FAU - Feuerlein, Katharina AU - Feuerlein K AD - Fakultat fur Gesundheit, University Witten/Herdecke, Witten, Germany. RINGGOLD: 235785 FAU - Stanislas, Virginie AU - Stanislas V AD - Institute for Prevention and Cancer Epidemiology (IPE), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. RINGGOLD: 14879 FAU - Zerback, Tim AU - Zerback T AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. FAU - Weder, Stine AU - Weder S AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. FAU - Langler, Alfred AU - Langler A AD - Fakultat fur Gesundheit, Professur fur integrative Kinder- und Jugendmedizin, University Witten/Herdecke, Witten, Germany. RINGGOLD: 235785 AD - Gemeinschaftskrankenhaus Herdecke, Klinik fur Kinder- und Jugendmedizin, Herdecke, Germany. FAU - Alexy, Ute AU - Alexy U AD - Institute of Nutritional and Food Sciences-Nutritional Epidemiology, University of Bonn, Bonn, Germany. RINGGOLD: 9374 FAU - Keller, Markus AU - Keller M AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. LA - eng PT - Journal Article DEP - 20260803 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Vegan diet OT - infants OT - maternal nutrition OT - newborn OT - plant-based diet OT - pregnancy OT - premature birth OT - vegetarian diet EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:42 CRDT- 2026/08/03 09:52 PHST- 2026/08/03 12:42 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 09:52 [entrez] AID - 10.1177/02601060261474598 [doi] PST - aheadofprint SO - Nutr Health. 2026 Aug 3:2601060261474598. doi: 10.1177/02601060261474598. PMID- 42544816 OWN - NLM STAT- Publisher LR - 20260803 IS - 1549-8425 (Electronic) IS - 1549-8417 (Linking) DP - 2026 Aug 3 TI - A Prospective Randomized Controlled Simulation Study to Test a Proof-of-Concept Real-Time Periprocedural Decision Support System to Aid in Timely Diagnosis and Intervention on Patient Deterioration. LID - 10.1097/PTS.0000000000001573 [doi] AB - OBJECTIVES: The recent pilot simulation study by Greenberg and colleagues introduced a proof-of-concept audio-visual support system for anesthesiology professional management of perioperative patient deterioration. The results demonstrated that real-time decision support for providers may enhance diagnostic accuracy/efficiency. In collaboration with Greenberg and colleagues, the authors from Massachusetts General Brigham (MGB) similarly developed a realistic operating room simulation environment at Massachusetts General Hospital (MGH) Learning Center. Here, the ability of anesthesiology trainees to accurately diagnose and treat using audio-visual cues was measured. METHODS: This study is a prospective, randomized controlled pilot trial adapted from a recent study further investigating the impact of audio-visual decision support on anesthesiology resident and student nurse anesthetist diagnostic accuracy and efficiency. This study took place entirely at Massachusetts General Hospital Center for Simulation and Innovation. Twenty-one anesthesiology trainees were randomized into 2 groups: (1) standard of care (control) versus (2) audio-visual cue group (experimental). The experimental group received audio-visual cues such as a choice of possible diagnoses from an experienced anesthesiologist and subsequent recommended interventions from the Stanford emergency manual and based on changes in the simulated patient's vitals. Each participant underwent 3 experimental simulations where patient deterioration occurs. These included: anaphylaxis, amniotic fluid embolism (AFE), and pulseless electrical activity (PEA) arrest during a pediatric dental case. Key time points and accuracy of diagnoses and treatment steps were recorded. RESULTS: The simulation scenario recordings for 10 anesthesiology residents and 11 student nurse anesthetists of various training years were investigated. For the anaphylaxis scenario, there was a statistically significant increase in the number of participants who correctly executed intervention 1 in the intervention group compared with the control group (P=0.0015). For the AFE scenario, there was a statistically significant increase in the median time to intervention 1 for SRNAs in the intervention group compared with the control group (P=0.01). However, there was a statistically significant decrease in the median time to intervention 1 for residents in the intervention group compared with the control group (P=0.01). For the pediatric dental scenario, there was a statistically significant increase in the number of participants in the intervention group versus the control group who made the correct diagnosis 2 (P=0.005). In addition, there was a statistically significant increase in the number of participants in the intervention group versus the control group who made the correct diagnosis 3 (P=0.023). CONCLUSIONS: The results indicate that real-time audio and visual cues in a simulated operative environment may improve time to diagnosis and treatment. This effect has now been investigated across the training spectrum from resident trainees to attendings. On the basis of observations from these simulations, this mode of simulation can be an effective educational tool for simulation-based learning exercises. In education or real-time practice, additional dedicated research and development of decision support technology could be beneficial in improving safety during periprocedural care by guiding best training practices. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Dinkel, Anthony AU - Dinkel A AD - Department of Anesthesiology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA. FAU - Talluto, Justin AU - Talluto J FAU - Chinthareddy, Vikranth AU - Chinthareddy V FAU - McCarthy, Kevin AU - McCarthy K FAU - Vijaykumar, Dolly AU - Vijaykumar D FAU - Greenberg, Steven B AU - Greenberg SB FAU - Locke, Andrew R AU - Locke AR FAU - Heshmat, Claire AU - Heshmat C FAU - Huey, Nathan AU - Huey N FAU - Ellender, Stacey AU - Ellender S FAU - Shapiro, Fred E AU - Shapiro FE LA - eng PT - Journal Article DEP - 20260803 PL - United States TA - J Patient Saf JT - Journal of patient safety JID - 101233393 SB - IM OTO - NOTNLM OT - anesthesia OT - patient safety OT - simulation COIS- F.S. is a consultant for Fresenius-Kabi, USA, and GE Health care. S.G. is the Vice President of the Anesthesia Patient Safety Foundation and has ongoing studies funded by Merck & Co. Inc., Senzime AB, AstraZeneca AB, and Fresenius-Kabi. The remaining authors disclose no conflict of interest. EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:42 CRDT- 2026/08/03 07:32 PHST- 2024/12/17 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/03 12:42 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 07:32 [entrez] AID - 01209203-990000000-00539 [pii] AID - 10.1097/PTS.0000000000001573 [doi] PST - aheadofprint SO - J Patient Saf. 2026 Aug 3. doi: 10.1097/PTS.0000000000001573. PMID- 42544636 OWN - NLM STAT- Publisher LR - 20260803 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) DP - 2026 Aug 3 TI - Adaptation of the IOWA Infant Feeding Attitude Scale Into Turkish for Mothers With Infants Aged 0-12 Months: A Validity and Reliability Study. PG - 8903344261460322 LID - 10.1177/08903344261460322 [doi] AB - BACKGROUND: Mothers' attitudes toward infant feeding are an important factor influencing breastfeeding intention, the initiation of breastfeeding, and the introduction of complementary feeding. AIM: The goal of the study was to culturally adapt the Iowa Infant Feeding Attitude Scale (IIFAS) to Turkish society and to test its validity and reliability. METHODS: This methodological study was conducted on a sample of 304 mothers with infants aged 0-12 months who consented to participate. Data were collected using the Participant Information Form and the Iowa Infant Feeding Attitude Scale. RESULTS: The total variance explained by the IIFAS was 43.966%. Item 1 was left out of further analyses on account of its impact on the scale's Cronbach's alpha value, and Item 17 was excluded due to its failing to meet the factor loading criterion. The chi(2)/df value in the confirmatory factor analysis was 1.745, and the fit indices indicated good model fit (RMSEA = 0.070, GFI = 0.893, CFI = 0.897). The reliability of the scale and subscales was found to be satisfactory. The item-total correlation values were found acceptable as their values range between 0.316 and 0.467. The mean total IIFAS score was 57.32 +/- 7.83. CONCLUSION: The results of the study indicated a neutral attitude score from mothers on the scale. In this regard, nurses ought to design a structured breastfeeding education and counseling intervention for mothers to develop a more positive attitude towards breastfeeding. The IIFAS is a valid tool and can be used to measure the infant feeding attitudes of mothers in Turkey. FAU - Arslan, Nurten AU - Arslan N AUID- ORCID: 0000-0003-1980-5661 AD - Pediatric Nurse, Department of Pediatric Nursing, Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. FAU - Kurtuncu, Meltem AU - Kurtuncu M AD - Department of Pediatric Nursing, Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. FAU - Gul, Sadiye Gulistan AU - Gul SG AD - Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. LA - eng PT - Journal Article DEP - 20260803 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM OTO - NOTNLM OT - Bebek Beslenmesi OT - Emzirme OT - Gecerlilik ve Guvenirlik OT - Psikometrik Ozellikler OT - Tutum OT - attitude OT - breastfeeding OT - infant nutrition OT - psychometric properties OT - validity and reliability EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:42 CRDT- 2026/08/03 06:52 PHST- 2026/08/03 12:42 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 06:52 [entrez] AID - 10.1177/08903344261460322 [doi] PST - aheadofprint SO - J Hum Lact. 2026 Aug 3:8903344261460322. doi: 10.1177/08903344261460322. PMID- 42544631 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 1118-4841 (Print) IS - 1118-4841 (Linking) VI - 30 IP - 14 DP - 2026 Aug 3 TI - Psychosocial determinants of postpartum blues among matrilineal mothers in West Sumatra, Indonesia. LID - . (Afr J Reprod Health 2026; 30 [14]: 57-65). [pii] LID - 10.29063/ajrh2026/v30i14.7 [doi] AB - Postpartum blues typically occur during the first two weeks after childbirth and may increase the risk of subsequent depressive disorders. In Minangkabau communities of West Sumatra, Indonesia, where matrilineal family systems and neo-local or dual family residence systems exist and husbands frequently migrate, it is insufficiently understood how family structure and partner presence may influence the maternal mood. This study aimed to examine psychosocial determinants of postpartum blues among 240 postpartum mothers between 3 to 14 days postpartum, in Pariaman, West Sumatra, Indonesia. Using a cross-sectional and prospective design, data were collected through face-to-face interviews using validated instruments, including the Pittsburgh Sleep Quality Index (PSQI), Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF), Perceived Stress Scale (PSS-10), and Indonesian Maternal Blues Scale (IMBS). Statistical analysis to identify independent predictors of postpartum blues was performed through descriptive statistics, bivariate analysis, and multivariable logistic regressions. The mean maternal age was 28.6 years old, and 27.9% of participants met the criteria for postpartum blues. Sleep quality was poor for 86.7% of the respondents. The most significant psychosocial determinant of postpartum blues was perceived stress (OR 1.25; 95% CI 1.16-1.34; p < 0.001) and husband migration was borderline significant (OR 2.30; 95% CI 1.00-5.28; p = 0.050). In contrast, sleep quality, breastfeeding self-efficacy, and kin co-residence were not independently associated with postpartum blues. These findings highlight the importance of integrating early psychosocial screening, stress management interventions, and family-centered postpartum support into maternal health policies and primary healthcare services, particularly in culturally unique and migration-affected communities. CI - African Journal of Reproductive Health (c) 2026. FAU - Oktavia, Sesmi N AU - Oktavia SN FAU - Kanathasan, Jayasree S AU - Kanathasan JS LA - eng PT - Journal Article PL - Nigeria TA - Afr J Reprod Health JT - African journal of reproductive health JID - 9712263 SB - IM MH - Humans MH - Female MH - Indonesia/epidemiology MH - Cross-Sectional Studies MH - *Mothers/psychology MH - Adult MH - *Postpartum Period/psychology MH - Prospective Studies MH - *Depression, Postpartum/psychology/epidemiology MH - *Breast Feeding/psychology MH - *Stress, Psychological/psychology/epidemiology MH - Sleep Quality MH - Subjective Stress MH - Young Adult MH - Family Structure MH - Surveys and Questionnaires OTO - NOTNLM OT - Maternal mental health OT - Maternity blues OT - Mothers OT - Perceived stress OT - Postpartum period OT - breastfeeding COIS- The Authors declared no conflict of interest EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:43 CRDT- 2026/08/03 06:44 PHST- 2026/08/03 12:43 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 06:44 [entrez] AID - . (Afr J Reprod Health 2026; 30 [14]: 57-65). [pii] AID - 10.29063/ajrh2026/v30i14.7 [doi] PST - ppublish SO - Afr J Reprod Health. 2026 Aug 3;30(14):. (Afr J Reprod Health 2026; 30 [14]: 57-65).. doi: 10.29063/ajrh2026/v30i14.7. PMID- 42544552 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 2153-2176 (Electronic) IS - 2153-2168 (Linking) VI - 22 IP - 8 DP - 2026 Dec TI - Reliability and Repeatability of At-Home Parent-Reported Height and Weight Measurement of Young Children. PG - 479-484 LID - 10.1177/21532176261474683 [doi] AB - Accurate anthropometric measurement is essential for monitoring child growth, yet access to in-person measurement collection can be limited. This study examines the reliability and repeatability of height and weight measurements taken at home by a single parent compared to those taken by a trained researcher team in a clinical setting. Thirty children aged 2-5 years enrolled in the TARGet Kids! cohort were measured by two trained researchers working in a pair and by their parent at home using standardized instructions. Technical error of measurement (TEM), relative TEM (%TEM), and the coefficient of reliability (R) were used to assess measurement reliability. Results demonstrated high reliability and repeatability of parent-reported measurements, particularly for weight. Bland-Altman plots showed slightly greater variation in height measurements collected by the parent at home, though still within acceptable limits. These findings support the use of parent-collected anthropometry at home, which may enhance accessibility for research and clinical care when in-person measurement is not feasible. FAU - Rae, Sarah AU - Rae S AUID- ORCID: 0000-0002-7025-3658 AD - Child Health Evaluative Sciences, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada. AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. FAU - Keown-Stoneman, Charles AU - Keown-Stoneman C AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. AD - Applied Health Research Centre (AHRC), Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada. FAU - Pullenayegum, Eleanor AU - Pullenayegum E AD - The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Ong, Frank AU - Ong F AD - Child Health Evaluative Sciences, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Dennis, Cindy-Lee AU - Dennis CL AD - Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada. FAU - Hamilton, Jill AU - Hamilton J AD - Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Maguire, Jonathon AU - Maguire J AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. AD - MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Division of Paediatrics, St Michael's Hospital, Toronto, Ontario, Canada. FAU - Birken, Catherine S AU - Birken CS AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. AD - Division of Paediatric Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. LA - eng PT - Journal Article DEP - 20260803 PL - United States TA - Child Obes JT - Childhood obesity (Print) JID - 101542497 SB - IM MH - Humans MH - Child, Preschool MH - Reproducibility of Results MH - *Body Height/physiology MH - Female MH - *Parents MH - Male MH - *Body Weight/physiology MH - *Anthropometry/methods OTO - NOTNLM OT - anthropometric measurement OT - child health OT - early childhood obesity OT - growth monitoring OT - measurement reliability OT - parent-reported data COIS- Author Disclosure StatementNo conflicts of interest to disclose. There are no prior publications or submissions with overlapping information, including studies or participants. EDAT- 2026/08/03 06:36 MHDA- 2026/10/15 07:17 CRDT- 2026/08/03 05:43 PHST- 2026/10/15 07:17 [medline] PHST- 2026/08/03 06:36 [pubmed] PHST- 2026/08/03 05:43 [entrez] AID - 10.1177/21532176261474683 [doi] PST - ppublish SO - Child Obes. 2026 Dec;22(8):479-484. doi: 10.1177/21532176261474683. Epub 2026 Aug 3. PMID- 42544273 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260803 LR - 20260813 IS - 0915-5287 (Print) IS - 2187-5626 (Electronic) IS - 0915-5287 (Linking) VI - 38 IP - 8 DP - 2026 Aug TI - Feasibility of short-term supine rehabilitation for pediatric orthostatic intolerance: a case series. PG - 347-352 LID - 10.1589/jpts.38.347 [doi] AB - [Purpose] This pilot feasibility case series examined the safety, tolerability, and implementability of a short-term inpatient supine exercise program using a low-load bicycle ergometer in pediatric patients with orthostatic intolerance (OI). [Participants and Methods] Four adolescents with OI who had difficulty attending school participated in a 10-13-day inpatient rehabilitation program. The intervention consisted of daily supine ergometer exercise (5-min warm-up, 15-min active pedaling, 5-min cool-down). Feasibility outcomes included completion rate, adherence, and adverse events. Exploratory clinical outcomes included heart rate (HR) response during standing tests, perceived exertion using a 100-mm visual analog scale (VAS), and school attendance two weeks after discharge. [Results] All participants completed the program without adverse events, demonstrating good feasibility and safety. Adherence to supervised sessions was high, and all patients performed self-training. Improvements in perceived exertion were observed in all cases, whereas changes in HR responses were variable. School attendance improved in three patients, although only two were able to attend more than three days per week. [Conclusion] A short-term supine ergometer program appears feasible, safe, and well tolerated in pediatric patients with OI. Given the small sample size, lack of controls, and reliance on subjective outcomes, these findings should be interpreted cautiously. CI - 2026(c)by the Society of Physical Therapy Science. Published by IPEC Inc. FAU - Ohnishi, Takumi AU - Ohnishi T AD - Department of Rehabilitation, Nara Prefectural General Medical Center, Japan. FAU - Mano, Tomoo AU - Mano T AD - Department of Rehabilitation, Nara Prefectural General Medical Center, Japan. AD - Department of Neurology, Nara Medical University: 840 Shijo-cho, Kashihara-shi, Nara 634-8521, Japan. FAU - Nishikawa, Hiroki AU - Nishikawa H AD - Department of Pediatrics, Nara Prefectural General Medical Center, Japan. FAU - Ozaki, Yumi AU - Ozaki Y AD - Department of Rehabilitation, Nara Prefectural General Medical Center, Japan. FAU - Masuda, Takashi AU - Masuda T AD - Department of Rehabilitation, Nara Prefectural General Medical Center, Japan. FAU - Yoshida, Sayaka AU - Yoshida S AD - Department of Pediatrics, Nara Prefectural General Medical Center, Japan. LA - eng PT - Journal Article DEP - 20260801 PL - Japan TA - J Phys Ther Sci JT - Journal of physical therapy science JID - 9105359 PMC - PMC13429274 OTO - NOTNLM OT - Orthostatic intolerance OT - Pediatric rehabilitation OT - Supine exercise COIS- The authors declare no conflicts of interest. EDAT- 2026/08/03 06:36 MHDA- 2026/08/03 06:37 PMCR- 2026/08/01 CRDT- 2026/08/03 03:53 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/24 00:00 [accepted] PHST- 2026/08/03 06:37 [medline] PHST- 2026/08/03 06:36 [pubmed] PHST- 2026/08/03 03:53 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 2026-027 [pii] AID - 10.1589/jpts.38.347 [doi] PST - ppublish SO - J Phys Ther Sci. 2026 Aug;38(8):347-352. doi: 10.1589/jpts.38.347. Epub 2026 Aug 1. PMID- 42542449 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 80 IP - 10 DP - 2026 Oct TI - Segmental BIA-derived body composition in children and adolescents aged 5-18 years: age- and sex-specific reference values and limitations in obesity. PG - 1062-1069 LID - 10.1038/s41430-026-01788-1 [doi] AB - BACKGROUND/OBJECTIVES: Bioimpedance analysis (BIA) is a non-invasive method for estimating fat-free mass (FFM) and fat mass (FM) via resistance (Rz) and reactance (Xc). Despite its potential, its usefulness and accuracy in children remain controversial. SUBJECTS/METHODS: We obtained body composition measurements from 2954 visits involving 1547 participants (aged 5-21 years) using segmental BIA measurements and skinfold-based equations (Slaughter et al.). Four independent analyses were conducted: (1) agreement of Rz and Xc measurements between body segments was assessed; (2) sex- and age-specific reference curves for height-normalized resistance (Rz/H) and reactance (Xc/H) were developed; (3) associations between changes in BMI-SDS, Rz/H, and Xc/H (SDS) were examined; and (4) FM estimates derived from the proprietary algorithm, an alternative formula-based BIA algorithm, and skinfold-based equations were compared with age adjustment. RESULTS: Segmental Rz/H and Xc/H measurements showed "excellent" (>0.9) intraclass correlations for all segments. Concordance correlation coefficients indicated variable agreement between methods. Age- and sex-specific Rz/H and Xc/H percentile curves showed similar progressions across body segments. Rz/H (SDS) and Xc/H (SDS) showed a clear association with BMI-SDS, with lower values in participants with obesity. Estimated FFM and FM showed discrepancies between estimation methods depending on weight status rather than age. CONCLUSION: Rz/H and Xc/H showed consistent age-related patterns but were strongly influenced by BMI-SDS. While agreement between FM estimates was good in normal-weight children, substantial discrepancies were observed in those with obesity. These findings suggest that current BIA-based estimation approaches may be unreliable in children and adolescents with obesity. CI - (c) 2026. The Author(s). FAU - Boker, Klara AU - Boker K AUID- ORCID: 0009-0006-9354-6791 AD - Leipzig University, Medical Faculty, University Hospital for Children and Adolescents Leipzig, Center for Pediatric Research (CPL), LIFE Child, Leipzig, Germany. Klara.Boeker@medizin.uni-leipzig.de. FAU - Vogel, Mandy AU - Vogel M AUID- ORCID: 0000-0003-2051-1249 AD - Leipzig University, Medical Faculty, University Hospital for Children and Adolescents Leipzig, Center for Pediatric Research (CPL), LIFE Child, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. FAU - Grundmann, Annelie AU - Grundmann A AD - Leipzig University, Medical Faculty, University Hospital for Children and Adolescents Leipzig, Center for Pediatric Research (CPL), LIFE Child, Leipzig, Germany. FAU - Kiess, Wieland AU - Kiess W AD - Leipzig University, Medical Faculty, University Hospital for Children and Adolescents Leipzig, Center for Pediatric Research (CPL), LIFE Child, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. LA - eng PT - Journal Article DEP - 20260801 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Adolescent MH - *Body Composition MH - Child, Preschool MH - Male MH - Reference Values MH - Child MH - *Electric Impedance MH - Female MH - Body Mass Index MH - Skinfold Thickness MH - *Obesity MH - Age Factors MH - Sex Factors MH - Algorithms MH - Young Adult MH - Reproducibility of Results MH - Adipose Tissue PMC - PMC13690603 COIS- Competing interests: The authors declare no competing interests. Ethical approval: The LIFE Child Study was designed in accordance with the Declaration of Helsinki. Approval from the Ethics Committee of the University of Leipzig took place in 2010 (reference number: Reg. No. 264-10-19042010). Fully informed and written consent was obtained from each participant and their parents at each visit to the study outpatient clinic. EDAT- 2026/08/02 00:50 MHDA- 2026/10/23 23:30 PMCR- 2026/08/01 CRDT- 2026/08/01 23:18 PHST- 2025/07/16 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/06/22 00:00 [revised] PHST- 2026/10/23 23:30 [medline] PHST- 2026/08/02 00:50 [pubmed] PHST- 2026/08/01 23:18 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 10.1038/s41430-026-01788-1 [pii] AID - 1788 [pii] AID - 10.1038/s41430-026-01788-1 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Oct;80(10):1062-1069. doi: 10.1038/s41430-026-01788-1. Epub 2026 Aug 1. PMID- 42542448 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 80 IP - 10 DP - 2026 Oct TI - Food selection, cardiorespiratory fitness and the longitudinal association with adiposity among South African school children: the ExAMIN Youth SA study. PG - 1025-1032 LID - 10.1038/s41430-026-01799-y [doi] AB - BACKGROUND: The global pandemic of paediatric obesity, unhealthy diets and physical inactivity are important future health challenges. The purpose of this study was to determine 4-year changes in food selection, cardiorespiratory fitness (CRF), and the longitudinal association with the development of adiposity among South African primary school-age children. METHODS: School children aged 5-9 years old in 2017 (n = 950) were followed up for four years. Parents indicated selection from healthy and unhealthy food groups in a validated questionnaire. Weight and height of the children were measured, and WHO BMI z-score (BAZ) was calculated. CRF was determined by the 20 m shuttle run test (20-m SRT). Changes in food selection frequency, CRF and BAZ were assessed. The association between frequency of food group selection, age, household income and CRF with 4-year change in BAZ was determined using mixed linear models. RESULTS: BAZ (p < 0.001) and age-adjusted performance in the 20-m SRT of boys (p = 0.04) increased at follow-up. The frequency of sugar-sweetened beverages (p < 0.001) and milk intake (p < 0.02) decreased, while the intake from fast-foods increased (p = 0.001). Daily intakes of vegetables and milk were associated with decreases in BAZ. A trend of a positive association was found between frequency of SSB intake and BAZ. CRF showed a strong negative association with BAZ over time (p < 0.001). CONCLUSIONS: Higher daily vegetable and milk intakes, as well as higher levels of CRF were protective against increasing adiposity among school-age children. The promotion of healthy eating and measures to improve CRF among school children are important priorities. CI - (c) 2026. The Author(s). FAU - Kruger, Herculina Salome AU - Kruger HS AUID- ORCID: 0000-0002-5365-1777 AD - Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa. salome.kruger@nwu.ac.za. AD - Medical Research Council Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. salome.kruger@nwu.ac.za. FAU - Ricci, Cristian AU - Ricci C AUID- ORCID: 0000-0003-4113-8682 AD - African Unit for Transdisciplinary Health Research, North-West University, Potchefstroom, South Africa. FAU - Pienaar, Anita Elizabeth AU - Pienaar AE AD - Physical Activity, Sport and Recreation Research Focus Area, North-West University, Potchefstroom, South Africa. FAU - Monyeki, Makama Andries AU - Monyeki MA AD - Physical Activity, Sport and Recreation Research Focus Area, North-West University, Potchefstroom, South Africa. FAU - van Zyl, Tertia AU - van Zyl T AD - Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa. AD - Medical Research Council Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. FAU - Ricci, Hannah AU - Ricci H AD - African Unit for Transdisciplinary Health Research, North-West University, Potchefstroom, South Africa. FAU - Kruger, Ruan AU - Kruger R AUID- ORCID: 0000-0001-7680-2032 AD - Medical Research Council Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. AD - Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa. LA - eng GR - 86895/South African Medical Research Council (SAMRC)/ PT - Journal Article DEP - 20260801 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Male MH - Child MH - South Africa/epidemiology MH - *Cardiorespiratory Fitness/physiology MH - Female MH - Longitudinal Studies MH - *Adiposity/physiology MH - Child, Preschool MH - *Food Preferences MH - *Diet/statistics & numerical data MH - Body Mass Index MH - *Pediatric Obesity/epidemiology MH - Animals MH - Schools PMC - PMC13690588 COIS- Competing interests: HSK is a member of the Research Grants Panel of the South African Sugar Association and receives an honorarium for the review of grant applications. The South African Sugar Association played no role in the design of the study, collection and analysis of data and the decision to submit this manuscript for publication. The other authors declare no competing interests. Ethical approval: The study protocol was approved by the Centre of Excellence Scientific Review Committee of the North-West University. The researchers obtained approval from the Health Research Ethics Committee (NWU-00091-16-A1) of the North-West University to conduct the study. The parents and caregivers signed informed consent forms for the children while children, whose parents consented, signed assent forms for their participation in the study after they were provided with information about this study and their role and rights as participants. All methods were performed in accordance with the relevant guidelines and regulations. Anthropometry methods were performed according to the International Society for the Advancement of Kinanthropometry protocol. The food group questionnaire data collection was based on validated questionnaire methods. The 20 m shuttle run methods were performed according to published guidelines for the assessment and interpretation of data in relation to youth aerobic fitness and health. EDAT- 2026/08/02 00:50 MHDA- 2026/10/23 23:30 PMCR- 2026/08/01 CRDT- 2026/08/01 23:18 PHST- 2025/08/14 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/06/26 00:00 [revised] PHST- 2026/10/23 23:30 [medline] PHST- 2026/08/02 00:50 [pubmed] PHST- 2026/08/01 23:18 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 10.1038/s41430-026-01799-y [pii] AID - 1799 [pii] AID - 10.1038/s41430-026-01799-y [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Oct;80(10):1025-1032. doi: 10.1038/s41430-026-01799-y. Epub 2026 Aug 1. PMID- 42542003 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 1878-0334 (Electronic) IS - 1871-4021 (Linking) VI - 20 IP - 7 DP - 2026 Jul TI - Body shape index and body roundness index: Novel anthropometric indices to identify diabetes mellitus among the Indian population. PG - 103468 LID - S1871-4021(26)00095-0 [pii] LID - 10.1016/j.dsx.2026.103468 [doi] AB - AIMS: We aimed to compare the discriminatory performance of Body Shape Index and Body Roundness Index with traditional anthropometric measures, including body mass index, waist circumference, and waist-to-height ratio, for identifying prevalent diabetes among Indian adults. METHODS: Data from the fifth round of the National Family Health Survey were analyzed, including 574,099 women and 74,761 men (aged 15-49 years). Diabetes was defined by self-reported diagnosis, current use of glucose-lowering medication, or a random blood glucose >/=200 mg/dL. Anthropometric indices were derived from measured height, weight, and waist circumference. Survey-weighted prevalence estimates, multivariable logistic regression, receiver operating characteristic analysis, DeLong tests, and trend tests were used. RESULTS: The weighted prevalence of diabetes was 13.6% and increased with age, urban residence, higher wealth, education, obesity, and hypertension. Waist circumference showed the highest correlation with diabetes (r = 0.1446) and the highest, though modest, discrimination (area under the curve = 0.61). Body mass index, Body Roundness Index, and waist-to-height ratio performed similarly (area under the curve = 0.60 each), whereas Body Shape Index showed the lowest discrimination (area under the curve = 0.55). DeLong comparisons showed that waist circumference and Body Roundness Index performed significantly better than Body Shape Index, while Body Roundness Index showed no meaningful incremental discrimination beyond waist-to-height ratio. CONCLUSIONS: Waist circumference, waist-to-height ratio, and Body Roundness Index performed similarly to, and modestly better than, the Body Shape Index for identifying prevalent diabetes in Indian adults. Simpler waist-based measures, particularly waist circumference and waist-to-height ratio, may be sufficient for population-level diabetes risk screening. CI - Copyright (c) 2026 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved. FAU - Verma, Madhur AU - Verma M AD - Community and Family Medicine, All India Institute of Medical Sciences, Bathinda, India. Electronic address: drmadhurverma@gmail.com. FAU - Halder, Pritam AU - Halder P AD - Department of Community Medicine, School of Public Halth, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address: rynedann@gmail.com. FAU - Jeer, Girish AU - Jeer G AD - Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India. Electronic address: drgirish.jeer@gmail.com. FAU - Kapoor, Nitin AU - Kapoor N AD - Endocrinology, Dept. of Endocrine, Diabetes and Metabolism, Christian Medical College, Vellore, TN, 632004, India; Non-communicable Disease Unit, The Baker Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia. Electronic address: nitin.endocrine@gmail.com. FAU - Kochhar, Sonia AU - Kochhar S AD - Physiology, All India Institute of Medical Sciences Bathinda, India. Electronic address: kochhar.sonia.dr@gmail.com. FAU - Prabha, Indu AU - Prabha I AD - Community and Family Medicine, All India Institute of Medical Sciences, Bathinda, India. Electronic address: prabhaindu01@gmail.com. FAU - Kakkar, Rakesh AU - Kakkar R AD - Community & Family Medicine, All India Institute of Medical Sciences, Bathinda, 151001, India. Electronic address: drrakesh75@rediffmail.com. FAU - Kalra, Sanjay AU - Kalra S AD - Endocrinology, Bharti Hospital, Karnal, Haryana, India; University Centre for Research and Development, Chandigarh University, Mohali, India. Electronic address: brideknl@gmail.com. LA - eng PT - Journal Article DEP - 20260728 PL - Netherlands TA - Diabetes Metab Syndr JT - Diabetes & metabolic syndrome JID - 101462250 SB - IM MH - Humans MH - Male MH - Middle Aged MH - Adult MH - India/epidemiology MH - Female MH - *Diabetes Mellitus/epidemiology/diagnosis MH - *Body Mass Index MH - Adolescent MH - *Waist Circumference MH - Young Adult MH - *Waist-Height Ratio MH - Prognosis MH - Prevalence MH - Follow-Up Studies MH - *Anthropometry MH - Cross-Sectional Studies MH - Risk Factors MH - *Obesity/epidemiology OTO - NOTNLM OT - Anthropometric measures OT - Barophenotype OT - Body roundness index OT - Body shape index OT - Diabetes mellitus OT - India OT - National family health survey OT - Obesity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/02 00:50 MHDA- 2026/09/16 23:34 CRDT- 2026/08/01 18:06 PHST- 2025/08/06 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/16 23:34 [medline] PHST- 2026/08/02 00:50 [pubmed] PHST- 2026/08/01 18:06 [entrez] AID - S1871-4021(26)00095-0 [pii] AID - 10.1016/j.dsx.2026.103468 [doi] PST - ppublish SO - Diabetes Metab Syndr. 2026 Jul;20(7):103468. doi: 10.1016/j.dsx.2026.103468. Epub 2026 Jul 28. PMID- 42541538 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Mandibular condylar cortication and third molar apical closure on cone beam computed tomography for the assessment of legal adulthood: a pilot retrospective study. PG - 4289-4297 LID - 10.1007/s00414-026-03932-9 [doi] AB - INTRODUCTION: Accurate estimation of legal adulthood in undocumented individuals remains a major challenge in forensic and medico-legal contexts. This study evaluates mandibular condylar cortication and third molar apical closure assessed by cone beam computed tomography (CBCT) as potential indicators of age of majority. A retrospective observational pilot study was conducted on 142 individuals aged 13-25 years from six geographic regions (Spain, Uruguay, Peru, Mexico, Venezuela and Colombia). Two radiological variables were analyzed: the presence of cortical bone in the mandibular condyle and apical closure of the mandibular third molars. Associations with chronological age were explored descriptively, considering sex and geographic origin. RESULTS: Mandibular condylar cortication was identified exclusively in individuals aged 18 years or older. It showed 89.2% sensitivity, 100% specificity, 100% positive predictive value, and 89.5% negative predictive value for identifying legal adulthood. Complete third molar apical closure showed lower sensitivity (64.7%) and specificity of 96.6%. Both markers were significantly associated with legal adulthood (Fisher's exact test, p < 0.001). CONCLUSION: Within the limitations of this pilot study, mandibular condylar cortication assessed by CBCT appears to be a promising indicator of legal adulthood, potentially offering higher specificity than third molar apical closure. Further large-scale studies are required to validate these findings. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Martinez-Mirave, Araceli P AU - Martinez-Mirave AP AD - Faculty of Dentistry, UIC Barcelona, Sant Cugat del Valles, Barcelona, Spain. FAU - Abecasis, Pedro Maria AU - Abecasis PM AD - IUEM - Instituto Universitario Egas Moniz, Lisbon, Portugal. FAU - Jaureguy, Santiago Andres AU - Jaureguy SA AD - Faculty of Dentistry, UIC Barcelona, Sant Cugat del Valles, Barcelona, Spain. FAU - Satorres-Nieto, Marta AU - Satorres-Nieto M AD - Faculty of Dentistry, UIC Barcelona, Sant Cugat del Valles, Barcelona, Spain. msatorres@uic.es. LA - eng PT - Journal Article PT - Observational Study DEP - 20260801 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Cone-Beam Computed Tomography MH - Pilot Projects MH - Retrospective Studies MH - Male MH - Adult MH - Young Adult MH - Female MH - Adolescent MH - *Molar, Third/diagnostic imaging/growth & development MH - *Mandibular Condyle/diagnostic imaging/growth & development MH - *Age Determination by Teeth/methods MH - Sensitivity and Specificity MH - *Cortical Bone/diagnostic imaging MH - *Tooth Apex/diagnostic imaging/growth & development OTO - NOTNLM OT - Age estimation OT - CBCT OT - Cortication OT - Forensic dentistry OT - Mandibular condyle OT - Third molar COIS- Declarations. Ethics: This retrospective study was conducted in accordance with the principles of the Declaration of Helsinki. All CBCT scans were anonymized prior to analysis. Ethics approval: This study (Study Code: REC-ECL-2025-01) was approved by the Ethics Committee of the Clinica Universitaria d'Odontologia (CEIm), UIC Barcelona (Acta 8AG, approval date 09/04/2025). Consent to participate: The requirement for informed consent was waived due to the retrospective nature of the study and the use of anonymized CBCT images. The study protocol, including the request for waiver of informed consent, was reviewed and approved by the Ethics Committee. Clinical trial number: Not applicable. AI statement: The authors declare that artificial intelligence (AI) tools were used solely to assist in language refinement and improvement of manuscript clarity. All scientific content, study design, data analysis, and interpretation of results were performed by the authors. The authors take full responsibility for the accuracy and integrity of the work. Competing interests: The authors declare no competing interests. EDAT- 2026/08/02 00:30 MHDA- 2026/10/12 17:30 CRDT- 2026/08/01 11:13 PHST- 2026/06/05 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 11:13 [entrez] AID - 10.1007/s00414-026-03932-9 [pii] AID - 10.1007/s00414-026-03932-9 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):4289-4297. doi: 10.1007/s00414-026-03932-9. Epub 2026 Aug 1. PMID- 42541464 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260801 LR - 20260801 IS - 2757-6256 (Print) IS - 2757-6256 (Linking) VI - 61 IP - 8 DP - 2026 Jul 6 TI - Clinical and Etiological Evaluation of Male Patients with Central Precocious Puberty: Findings from a Single-Center Cohort. PG - 683-689 LID - 10.65717/TurkArchPediatr.2026.25562 [doi] AB - OBJECTIVE: Central precocious puberty (CPP) is considerably less common in boys than in girls, and its underlying causes are more heterogeneous. Although earlier reports emphasized a high frequency of central nervous system (CNS) lesions in affected boys, recent data suggest a rising proportion of idiopathic cases. METHODS: In this retrospective cross-sectional study, medical records of 46 boys diagnosed with CPP between 2015 and 2025 were reviewed. Clinical data included age at diagnosis, anthropometry, pubertal stage, bone age (BA), hormonal measurements, and brain magnetic resonance imaging (MRI) findings. Patients were categorized as idiopathic or neurogenic CPP according to MRI results. Group comparisons were performed using appropriate statistical tests, with P < .05 considered significant. RESULTS: The mean age at diagnosis was 8.17 +/- 1.73 years, and nearly half of the patients were referred for non-pubertal concerns. Magnetic resonance imaging (MRI) was normal in 68% of cases, while 32% had neurogenic CPP. The most frequent lesions were hypoxic-ischemic encephalopathy sequelae (20%), partial empty sella (20%), hypothalamic hamartoma (13%), and Rathke's cleft cysts (13%). No significant differences were found between idiopathic and neurogenic groups regarding basal luteinising hormone (LH), peak LH, testosterone levels, BA advancement, or pubertal stage at presentation. CONCLUSION: In this cohort, idiopathic CPP constituted the majority of cases in boys, supporting recent epidemiological trends. Clinical and hormonal parameters did not reliably distinguish neurogenic from idiopathic CPP, underscoring the continued importance of cranial MRI in evaluating boys with CPP. Larger, multi center studies with long-term follow-up are needed to refine risk stratification and imaging indications in this population. CI - Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Copyright (c) Author(s) - Available online at https://turkarchpediatr.org/EN. Published by the Turkish Pediatrics Association. FAU - Kontbay Cetin, Tugba AU - Kontbay Cetin T AUID- ORCID: 0000-0001-7702-8296 AD - Paediatric Endocrinology Department, Samsun Research and Training Hospital, Samsun, Turkiye. FAU - Acikgoz, Emel Gul AU - Acikgoz EG AUID- ORCID: 0009-0002-5627-4556 AD - Paediatric Endocrinology Department, Samsun Research and Training Hospital, Samsun, Turkiye. LA - eng PT - Journal Article DEP - 20260706 PL - Turkey TA - Turk Arch Pediatr JT - Turkish archives of pediatrics JID - 101776822 OTO - NOTNLM OT - Central precocious puberty OT - cranial MRI OT - idiopathic central precocious puberty OT - intracranial pathology OT - male patients COIS- The authors have no conflicts of interest to declare. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:31 CRDT- 2026/08/01 09:12 PHST- 2026/08/02 00:31 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 09:12 [entrez] AID - 10.65717/TurkArchPediatr.2026.25562 [doi] PST - epublish SO - Turk Arch Pediatr. 2026 Jul 6;61(8):683-689. doi: 10.65717/TurkArchPediatr.2026.25562. PMID- 42540724 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Criterion validity assessment of the 24-hour movement behaviors questionnaire (24HMBQ) for Chinese college students: validation study. PG - e21490 LID - 10.7717/peerj.21490 [doi] LID - e21490 AB - BACKGROUND: Accumulating studies have investigated the combined effects of 24-h movement behaviors on physical and mental health. The 24-hour Movement Behaviors Questionnaire (24HMBQ) was recently developed to measure the 24-hour movement behaviors in college students. However, its criterion validity remains to be elucidated. This study aimed to investigate the criterion validity of the 24HMBQ against accelerometer-derived data among Chinese college students. METHODS: Eighty-eight college students (age = 20.2 +/- 2.2 years) participated in this study. The Axivity AX3 accelerometers were used to objectively measure physical activity (PA), sedentary behavior (SB), and sleep levels over a consecutive seven-day period. At the last day, participants completed the 24HMBQ to self-report their PA, SB, and sleep levels. Paired-sample t-test, Spearman's rank correlation test, and Bland-Altman plot were used to examine the degree of agreement between 24HMBQ and accelerometer data. RESULTS: Spearman's correlation coefficients indicated strong agreement for sleep metrics (Rho = 0.77, p < 0.001 for weekdays; Rho = 0.68, p < 0.001 for weekends) and moderate agreement for SB (Rho = 0.55, p < 0.001 for weekdays; Rho = 0.33, p < 0.01 for weekends) between 24HMBQ and accelerometer measurements. However, lower correlations were observed for physical activities including light PA (Rho = 0.30, p < 0.01) and moderate-to-vigorous PA (MVPA; Rho = 0.15, p > 0.05). CONCLUSION: The 24HMBQ showed good criterion validity for sleep and moderate validity for sedentary behavior, but limited validity for physical activity (especially MVPA). CI - (c)2026 Tan et al. FAU - Tan, Teck Cheng AU - Tan TC AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zheng, Jiaxin AU - Zheng J AD - School of Physical Education and Sport Science, Fujian Normal University, Fuzhou, China. FAU - Chen, Tianle AU - Chen T AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Yiting AU - Liu Y AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Luo, Yan AU - Luo Y AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Yanxiang AU - Yang Y AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Huang, Tao AU - Huang T AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260728 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Female MH - *Students/statistics & numerical data MH - Surveys and Questionnaires/standards MH - Young Adult MH - *Exercise MH - Male MH - Accelerometry MH - Universities MH - Reproducibility of Results MH - *Sedentary Behavior MH - Sleep MH - China MH - Sleep Duration MH - Adolescent PMC - PMC13426337 OTO - NOTNLM OT - 24-hour movement behavior OT - Accelerometer OT - College students OT - Criterion validity OT - Questionnaire COIS- The authors declare there are no competing interests. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:31 PMCR- 2026/07/28 CRDT- 2026/08/01 06:42 PHST- 2025/12/15 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/08/02 00:31 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 06:42 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 21490 [pii] AID - 10.7717/peerj.21490 [doi] PST - epublish SO - PeerJ. 2026 Jul 28;14:e21490. doi: 10.7717/peerj.21490. eCollection 2026. PMID- 42540305 OWN - NLM STAT- Publisher LR - 20260923 IS - 2691-171X (Electronic) IS - 2691-171X (Linking) DP - 2026 Jul 31 TI - Barriers and facilitators to the national scale-up of a preterm standardised parenteral nutrition system: A mixed-methods evaluation. LID - 10.1002/jpr3.70213 [doi] AB - OBJECTIVE: Standardising parenteral nutrition (PN) care for preterm infants is recommended to enhance safety, outcomes and efficiency, however implementation at scale remains challenging. In 2021, Ireland scaled-up a standardised parenteral nutrition (SPN) system comprising SPN formulations and dosing protocol. We evaluate national scale-up to identify contextually relevant factors to optimise implementation. METHODS: A sequential explanatory mixed-methods process evaluation was conducted. Phase 1 comprised a cross-sectional survey of healthcare professionals (HCPs) across nine neonatal units (NUs), alongside analysis of PN purchasing data. Phase 2 included a focus group with the national implementation team and semi-structured interviews with HCPs from three NUs. Qualitative data were analysed using framework analysis guided by the Consolidated Framework for Implementation Research. RESULTS: For Phase 1, we analysed 158 survey responses (27.6% response rate). All NUs had adopted the SPN system; 95% HCPs reported 'Always' or 'Often' using the protocol. SPN accounted for 95% of PN purchased nationally, increasing from 56% pre-implementation. Usability and sustainment scores were significantly higher among trained HCPs (p = 0.026; p < 0.001). Protocol adaptations were reported by 21%, and 16% reported receiving no training. Phase 2 (1 focus group; 16 interviews) developed seven themes describing factors influencing scale-up. Key enablers included the perceived relative advantage of the intervention and strong national networks. Barriers included local policy misalignment, limited evidence in specific populations and hierarchical decision-making. CONCLUSION: Scale-up of SPN interventions is achievable in practice, however contextual factors influenced how the intervention was used. System-level infrastructure including training and ongoing monitoring is required to optimise implementation and equitable sustainment. CI - (c) 2026 The Author(s). JPGN Reports published by Wiley Periodicals LLC on behalf of The European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Fenton, Sarah AU - Fenton S AUID- ORCID: 0009-0004-6280-1708 AD - The Irish Centre for Maternal and Child Health Research (INFANT Research Centre) University College Cork Cork Ireland. AD - Pharmacy Department Cork University Hospital Cork Ireland. FAU - Brennan, Ann-Marie AU - Brennan AM AD - The Irish Centre for Maternal and Child Health Research (INFANT Research Centre) University College Cork Cork Ireland. AD - Department of Clinical Nutrition & Dietetics Cork University Maternity Hospital Cork Ireland. FAU - Fleming, Aoife AU - Fleming A AD - School of Pharmacy University College Cork Cork Ireland. FAU - Livingstone, Vicki AU - Livingstone V AD - The Irish Centre for Maternal and Child Health Research (INFANT Research Centre) University College Cork Cork Ireland. AD - Department of Paediatrics & Child Health University College Cork Cork Ireland. FAU - Murphy, Brendan AU - Murphy B AD - The Irish Centre for Maternal and Child Health Research (INFANT Research Centre) University College Cork Cork Ireland. AD - Department of Paediatrics University Hospital Waterford Waterford Ireland. FAU - Murphy, Aileen AU - Murphy A AD - Department of Economics, Cork University Business School University College Cork Cork Ireland. FAU - Dempsey, Eugene AU - Dempsey E AD - The Irish Centre for Maternal and Child Health Research (INFANT Research Centre) University College Cork Cork Ireland. AD - Department of Paediatrics & Child Health University College Cork Cork Ireland. AD - Department of Neonatology Cork University Maternity Hospital Cork Ireland. FAU - Heavin, Ciara AU - Heavin C AD - Cork University Business School University College Cork Cork Ireland. LA - eng PT - Journal Article DEP - 20260731 PL - United States TA - JPGN Rep JT - JPGN reports JID - 101773885 PMC - PMC13425788 OTO - NOTNLM OT - health service research OT - implementation science OT - neonatal COIS- The authors declare no conflict of interest. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:30 PMCR- 2026/07/31 CRDT- 2026/08/01 06:30 PHST- 2025/12/17 00:00 [received] PHST- 2026/05/06 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/08/02 00:30 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 06:30 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - JPR370213 [pii] AID - 10.1002/jpr3.70213 [doi] PST - aheadofprint SO - JPGN Rep. 2026 Jul 31:10.1002/jpr3.70213. doi: 10.1002/jpr3.70213. PMID- 42539860 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260801 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Virtual reality-based stress paradigms and early adversity: a scoping review of mechanisms and stress-response systems. PG - 1881373 LID - 10.3389/fpsyt.2026.1881373 [doi] LID - 1881373 AB - BACKGROUND/OBJECTIVES: Virtual reality (VR)-based stress paradigms are increasingly used to induce stress in controlled yet ecologically valid settings. However, the diversity of VR-based stress paradigms and their differential engagement of stress-response systems remain insufficiently synthesized. This scoping review aimed to map VR stress paradigms and examine how they engage subjective, autonomic, endocrine, neural, and behavioral responses, while considering the role of early adversity. METHODS: A structured literature search was conducted across Web of Science, ScienceDirect, SpringerLink, and Google Scholar for studies published between January 2012 and June 2026. Eligible studies used VR to induce stress and assessed psychological and/or physiological outcomes. After screening, 21 studies were included and grouped into clusters based on shared mechanisms and methodological features. RESULTS: Five clusters were identified: (1) social-evaluative, (2) cognitive/performance-based, (3) threat/fear-based, (4) analogue trauma, and (5) complex ecologically valid paradigms, with implications for stress-related behavioral outcomes, including eating behavior. VR consistently elicited subjective and autonomic responses, while endocrine and neural responses varied by paradigm type. Social-evaluative paradigms showed robust subjective and autonomic activation with variable hypothalamic-pituitary-adrenal axis responses. Threat-based paradigms elicited strong autonomic and affective responses, whereas cognitive paradigms were associated with performance-related stress and limited endocrine activation. Evidence on early adversity suggested differential sensitivity to specific stressor types; however, only a subset of studies directly assessed adverse childhood experiences or childhood trauma, and its role as a moderator of stress reactivity remains underexplored. CONCLUSIONS: VR-based stress paradigms do not induce stress as a unitary construct but selectively engage distinct response systems depending on paradigm characteristics. Integrating early adversity may enhance the precision of VR-based stress research. This framework may support future investigations of stress-related behaviors, including eating behavior, in ecologically valid environments. It may also offer promising applications for personalized nutrition; however, these implications were not directly assessed in the included studies. CI - Copyright (c) 2026 Singeap-Tiron, Onita, Matei, Dobrin, Gotca, Radeanu, Petrescu-Miron and Mocanu. FAU - Singeap-Tiron, Mara S AU - Singeap-Tiron MS AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania. AD - Institute of Psychiatry "Socola", Iasi, Romania. FAU - Onita, Cristiana Amalia AU - Onita CA AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania. FAU - Matei, Daniela Viorelia AU - Matei DV AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania. FAU - Dobrin, Petru Romeo AU - Dobrin PR AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania. AD - Institute of Psychiatry "Socola", Iasi, Romania. FAU - Gotca, Ioan AU - Gotca I AD - Institute of Psychiatry "Socola", Iasi, Romania. FAU - Radeanu, Mihaela-Alina AU - Radeanu MA AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania. FAU - Petrescu-Miron, Diana I AU - Petrescu-Miron DI AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania. FAU - Mocanu, Veronica AU - Mocanu V AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260717 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13424479 OTO - NOTNLM OT - HPA axis OT - adverse childhood experiences OT - autonomic nervous system OT - early adversity OT - eating behavior OT - psychosocial stress OT - stress paradigms OT - virtual reality COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:31 PMCR- 2026/07/17 CRDT- 2026/08/01 06:18 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/02 00:31 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 06:18 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1881373 [doi] PST - epublish SO - Front Psychiatry. 2026 Jul 17;17:1881373. doi: 10.3389/fpsyt.2026.1881373. eCollection 2026. PMID- 42539738 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260801 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Impact of standardized fortified donor human milk on growth parameters and biomarkers in preterm very low birth weight infants: a single-center propensity score-matched analysis. PG - 1851385 LID - 10.3389/fped.2026.1851385 [doi] LID - 1851385 AB - OBJECTIVE: This study aimed to evaluate the short-term clinical application effects of standardized fortified donor human milk (SF-DHM) in preterm very low birth weight (VLBW) infants, with a focus on its impact on growth parameters and relevant biomarkers, in order to provide scientific evidence for nutritional intervention strategies in cases of insufficient maternal milk supply. METHODS: A retrospective single-center study design was adopted. A total of 80 preterm VLBW infants hospitalized in the Neonatal Intensive Care Unit (NICU) of our hospital from January 2022 to March 2025 were included. Based on propensity score matching (PSM), infants were 1:1 matched according to variables such as sex, gestational age at birth, birth weight, and severity of illness, resulting in 40 infants in the control group and 40 in the observation group. The control group received conventional feeding based on maternal milk supplemented with formula as needed; the observation group received SF-DHM as the main enteral nutritional source after standardized nutritional fortification. The two groups were compared in terms of in-hospital growth parameters (weight gain velocity, head circumference growth velocity, length growth velocity, length of hospital stay, and incidence of extrauterine growth restriction at discharge), nutritional biomarkers [prealbumin (PA), albumin (ALB), total protein (TP)], inflammatory markers [interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha)], immune function markers (CD4+, CD8+, CD4+/CD8+), feeding tolerance, and incidence of complications. RESULTS: There were no significant differences in baseline characteristics between the two groups after matching (P > 0.05). Intervention outcomes showed that the observation group had superior weight gain velocity, head circumference growth velocity, length growth velocity, shorter hospital stay, and lower incidence of growth restriction at discharge compared to the control group (P < 0.05). After 3 months of intervention, PA, ALB, TP, CD4+, and CD4+/CD8+ levels increased in both groups, while IL-6, CRP, and TNF-alpha levels decreased, with greater changes observed in the observation group (P < 0.05). The observation group also had lower rates of feeding intolerance and complications than the control group (P < 0.05). CONCLUSION: SF-DHM offers significant benefits in promoting growth, improving nutritional status, reducing inflammation, and enhancing immune function in preterm VLBW infants with limited nutritional support. As a safe, feasible, and effective enteral nutrition strategy, SF-DHM holds broad clinical application potential in NICU settings and is recommended for prioritized use in the nutritional management of preterm infants. CI - (c) 2026 Zan, Zhang, Ma and Zhang. FAU - Zan, Hui AU - Zan H AD - Pediatrics Department, East Campus, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. FAU - Zhang, Xiaocui AU - Zhang X AD - Pediatrics Department, East Campus, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. FAU - Ma, Shan AU - Ma S AD - Pediatrics Department, East Campus, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. FAU - Zhang, Hong AU - Zhang H AD - Pediatrics Department, East Campus, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. LA - eng PT - Journal Article DEP - 20260717 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13424283 OTO - NOTNLM OT - biomarkers OT - growth and development OT - preterm infants OT - standardized donor human milk OT - very low birth weight infants COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:31 PMCR- 2026/07/17 CRDT- 2026/08/01 06:14 PHST- 2026/04/09 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/08/02 00:31 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 06:14 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.3389/fped.2026.1851385 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 17;14:1851385. doi: 10.3389/fped.2026.1851385. eCollection 2026. PMID- 42539487 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260801 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical literacy and mental well-being in adults: a cross-sectional examination of their association and links with physical activity engagement. PG - 1908692 LID - 10.3389/fpsyg.2026.1908692 [doi] LID - 1908692 AB - BACKGROUND: Physical literacy, the integrated motivation, confidence, physical competence, knowledge, and understanding that underpins lifelong physical activity, has been advanced as a holistic determinant of health. Yet, evidence linking it to positively framed mental well-being in adults remains scarce and is dominated by samples of children and adolescents. AIM: This study examined the association between physical literacy and mental well-being in Turkish adults and tested whether both constructs differed by sex, educational attainment, athletic background, regular exercise participation, and habitual physical activity level. METHODS: In a cross-sectional design, 375 adults (64.5% male; mean age = 32.23 years, SD = 11.03, range 18-71), a convenience sample skewed toward physically active and tertiary-educated men, completed validated Turkish measures of physical literacy and mental well-being. Active-living exposures were assessed using a single self-report item. Internal consistency was high (physical literacy alpha = 0.89, omega = 0.90; mental well-being alpha = 0.92, omega = 0.92). Pearson correlations, t-tests, one-way ANOVAs, and hierarchical regression were computed with effect sizes and 95% confidence intervals; discriminant validity was tested directly, and an exploratory mediation was examined. RESULTS: Physical literacy was moderately and positively associated with mental well-being (r = 0.45, p < 0.001), and the two constructs showed evidence of empirical distinctness (HTMT = 0.52, 95% CI [0.42, 0.63]). Adults with an athletic background and regular exercisers reported higher physical literacy (d = 0.83 and 1.09) and mental well-being (d = 0.36 and 0.63), and both outcomes increased in an ordered gradient across habitual activity-frequency categories (physical literacy eta(2) = 0.21; mental well-being eta(2) = 0.07). Physical literacy explained 11% of incremental variance in well-being beyond demographic and behavioral covariates (beta = 0.41). Men scored marginally higher than women on both measures, educational attainment was weakly related to mental well-being but not physical literacy, and physical literacy declined modestly with age (r = -0.18). CONCLUSION: Higher physical literacy co-occurs with better mental well-being in adults and remains associated with mental well-being after adjustment for covariates, positioning it as a candidate target for adult mental health promotion. The cross-sectional design and active, educated convenience sample preclude causal and population-level inference, and independent confirmatory validation of the adapted instrument is needed before these findings are treated as more than provisional. CI - Copyright (c) 2026 Orhan, Alkasasbeh, Karacam, Branquinho and Amawi. FAU - Orhan, Bekir Erhan AU - Orhan BE AD - Faculty of Sports Sciences, Istanbul Aydin University, Istanbul, Turkiye. FAU - Alkasasbeh, Walaa Jumah AU - Alkasasbeh WJ AD - Department of Physical Education, Faculty of Sport Science, The University of Jordan, Amman, Jordan. FAU - Karacam, Aydin AU - Karacam A AD - Faculty of Sport Sciences, Bandirma Onyedi Eylul University, Balikesir, Turkiye. FAU - Branquinho, Luis AU - Branquinho L AD - Biosciences School of Elvas, Polytechnic University of Portalegre, Elvas, Portugal. AD - Life Quality Research Center (LQRC-CIEQV), Santarem, Portugal. AD - Research Center in Sports Sciences, Health Sciences and Human Development, Covilha, Portugal. AD - Centro De Investigacao Do Instituto Superior De Ciencia Educativas (CI-ISCE), Penafiel, Portugal. FAU - Amawi, Adam Tawfiq AU - Amawi AT AD - Department of Movement Sciences and Sports Training, School of Sports Science, The University of Jordan, Amman, Jordan. LA - eng PT - Journal Article DEP - 20260717 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13423689 OTO - NOTNLM OT - health promotion OT - mental well-being OT - physical activity OT - physical literacy OT - self-determination theory OT - sustainable health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer AR declared a past collaboration with the authors BO and LB to the handling editor. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:31 PMCR- 2026/07/17 CRDT- 2026/08/01 06:07 PHST- 2026/06/14 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/02 00:31 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 06:07 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1908692 [doi] PST - epublish SO - Front Psychol. 2026 Jul 17;17:1908692. doi: 10.3389/fpsyg.2026.1908692. eCollection 2026. PMID- 42771750 STAT- Publisher PB - Canadian Agency for Drugs and Technologies in Health CTI - CADTH Reimbursement Reviews and Recommendations DP - 2026 Aug BTI - Maralixibat (Livmarli): Therapeutic area: Progressive familial intrahepatic cholestasis: Reimbursement Review AB - WHAT IS PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS? Progressive familial intrahepatic cholestasis (PFIC) is a rare, inherited liver disease that starts in infancy or childhood. It causes a buildup of bile acids in the liver, leading to severe itching (pruritus), sleep problems, poor growth, and, over time, liver damage that can require a transplant. PFIC is considered a rare condition; reliable prevalence estimates in Canada are not available, but cases are uncommon across all provinces and territories. WHAT ARE THE TREATMENT GOALS AND CURRENT TREATMENT OPTIONS FOR PFIC? The main goals of treatment are to reduce itching and improve sleep and daily life for children and families, support growth and nutrition, and prevent or delay serious liver problems and the need for transplant. From patient and caregiver perspectives, the most important outcomes are relief from itching, better sleep, improved skin, and improve quality of life. Clinicians place the greatest emphasis on halting liver disease progression and monitoring objective measures, such as serum bile acids and bilirubin, growth, and transplant-free survival. Current options in Canada include symptom-relief medicines (e.g., ursodeoxycholic acid, rifampin, cholestyramine, naltrexone), odevixibat (an IBAT inhibitor), and surgical procedures, such as biliary diversion. Liver transplant may be needed if disease progresses or morbidity becomes intolerable despite use of current therapies. WHAT IS LIVMARLI AND WHY DID CANADA'S DRUG AGENCY CONDUCT THIS REVIEW? Livmarli (maralixibat) is a medicine called an IBAT inhibitor that is taken orally. At the time of this review, Health Canada was reviewing Livmarli for the treatment of PFIC in patients 12 months of age and older. CDA-AMC reviewed Livmarli to inform participating public drug programs on whether it should be reimbursed for children and adults with PFIC who meet the Health Canada indication. HOW DID CDA-AMC EVALUATE LIVMARLI? CDA-AMC examined clinical evidence on the benefits and harms of Livmarli, compared with other treatments used in Canada for PFIC. Relevant comparators included odevixibat and usual medical or surgical care used for symptom control. CDA-AMC also identified ethical and equity considerations related to PFIC and its care (e.g., access to specialized pediatric liver services, the travel burden for families). The review was informed by materials submitted by the sponsor (clinical and economic evidence). CDA-AMC also considered input from patient and clinician communities and from public drug programs about issues that may affect real-world implementation. Clinical experts in pediatric hepatology and gastroenterology in Canada were consulted. WHAT WERE THE FINDINGS? CLINICAL EVIDENCE: * CDA-AMC reviewed the following clinical evidence: o.. one randomized controlled phase III trial (MARCH) comparing Livmarli with placebo in children with PFIC; o.. one long-term extension study (MARCH-ON) following children who received Livmarli over a longer period; o.. one indirect treatment comparison assessing Livmarli versus odevixibat using data from separate trials. * Livmarli versus placebo: Children receiving Livmarli had meaningful improvements in itching and blood markers of cholestasis. Families reported better sleep related to itching, improved skin, and gains in day-to-day functioning. * Harms: Side effects were mostly gastrointestinal (e.g., diarrhea, stomach pain) and vitamins A, D, E, and K changes related to the medicine's action. These were usually mild to moderate and managed with dose adjustments, routine monitoring, and vitamin supplementation when required. * Livmarli versus odevixibat: The indirect comparison between Livmarli and odevixibat, conducted without a head-to-head trial, suggested possible advantages of Livmarli on some biochemical measures. However, both studies used for the comparison were small and differed in design, making it uncertain which IBAT inhibitor offers greater overall benefit or if they were comparable. Notably, pruritus - the most burdensome symptom for patients - was not assessed, limiting conclusions to biochemical outcomes. * Evidence gaps: Studies involved relatively small numbers of children, with limited data in very young infants, children with advanced liver disease, and a limited number of PFIC genetic subtypes. Longer-term effects - such as survival, growth, bone health, vitamin levels, and transplant prevention - need more study. * Overall, Livmarli may represent a useful nonsurgical treatment option that targets bile acid accumulation and alleviates pruritus - the symptom identified by patients and families as the most burdensome. Further evidence is needed to confirm its long-term benefits and safety, to directly compare Livmarli with odevixibat, and to determine its impact on the progression and broader manifestations of liver disease in PFIC. ECONOMIC EVIDENCE: * Livmarli is available as a solution for oral administration (19 mg/mL in a 30 mL bottle) and oral tablets (i.e., 10 mg, 15 mg, 20 mg, and 30 mg). At the submitted price of $3,100.00/mL, the annual cost of Livmarli is expected to be between $263,004 and $3,315,450 per patient in the first year and $271,746 and $3,396,825 per patient in subsequent years, depending on patient weight, based on the Health Canada-recommended dosage. At the submitted price of $1,631.58 per 10 mg, $2,447.37 per 15 mg, $3,263.16 per 20 mg, and $4,894.74 per 30 mg, the annual per patient cost of Livmarli is expected to be $3,489,947 in the first year and $3,575,605 in subsequent years, assuming patient weight of 50 kg. * Key clinical efficacy data (i.e., pruritus response) in the economic analysis for Livmarli plus best supportive care (BSC) versus BSC alone was derived from the MARCH-PFIC trial. Evidence from the MARCH-PFIC trial indicated that Livmarli plus BSC is likely to improve pruritus response compared with placebo among children with PFIC. For Livmarli plus BSC versus odevixibat plus BSC, clinical efficacy was informed by a naive comparison of the MARCH-PFIC and PEDFIC 1 trials, respectively, in the pharmacoeconomic model. According to the CDA-AMC Clinical Review, no direct or indirect evidence on the relative efficacy of Livmarli plus BSC and odevixibat plus BSC is available for pruritus. The indirect treatment comparison suggested that Livmarli may be associated with greater biochemical efficacy compared with odevixibat; however, these findings were uncertain due to methodological limitations. * There is no robust evidence to suggest that Livmarli plus BSC provides greater health benefits to patients than odevixibat plus BSC in terms of pruritus response. If there are no differences in health outcomes between Livmarli and odevixibat, then the total cost of Livmarli to the health system should not exceed that of odevixibat for the treatment of PFIC in patients aged 3 months and older. The cost-effectiveness of Livmarli versus BSC alone is highly uncertain. Scenario analyses suggest that the incremental cost-effectiveness ratio may fall between $3,322,139 and $17,230,763 per quality-adjusted life-year gained, depending on whether there is a long-term liver and mortality benefit associated with Livmarli. * CDA-AMC estimates that the budget impact of reimbursing Livmarli plus BSC for the treatment of PFIC in patients aged 3 months and older will be approximately $44.6 million over the first 3 years of reimbursement compared to the amount currently spent on comparators, with an estimated expenditure of $45.6 million on Livmarli plus BSC over this period. The budget impact of Livmarli plus BSC is likely underestimated because it is based on an anticipated market share of only 5% in prevalent patient population with PFIC type 1 and 2. The actual budget impact of reimbursing Livmarli plus BSC will depend on the reimbursement status of odevixibat plus BSC for PFIC and resulting market share of Livmarli plus BSC and comparators. LA - eng PT - Review PT - Book PL - Ottawa (ON) RF - 13 EDAT- 2026/08/01 00:00 CRDT- 2026/08/01 00:00 AID - NBK624896 [bookaccession] PMID- 42539320 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260801 LR - 20260813 IS - 2688-4844 (Electronic) IS - 2688-4844 (Linking) VI - 7 DP - 2026 Jan-Dec TI - Obesity among Obstetrical Patients Seeking Care in a Safety Net Hospital: The Impact of Adverse Childhood Events. PG - 26884844261445331 LID - 10.1177/26884844261445331 [doi] LID - 26884844261445331 AB - OBJECTIVE: To determine the prevalence of obesity among a cohort of pregnant patients with high compared with low adverse childhood events scores. STUDY DESIGN DESCRIPTIVE STUDY METHODS: The study was part of a large study of adverse childhood events among pregnant women seeking care in a safety net hospital from June 2022 to June 2023. The patients were seen in a variety of settings (a routine prenatal clinic, a high-risk clinic, an antepartum testing unit, an obstetrical ultrasound unit, and a labor and delivery suite). They were randomly approached and asked to complete a previously validated questionnaire for their Adverse Childhood Experience score (ACE score). Their body mass index (BMI) on their first visit was recorded. BMI was categorized as overweight (BMI > 25), class I obesity (BMI > 30), class II obesity (BMI > 35), and class III obesity (BMI > 40). This study was approved by the Valleywise Institutional Review Board. RESULTS: Three hundred and forty-nine patients were approached and 320 agreed to complete the questionnaire. Eighty percent of patients had an initial prenatal visit BMI >25 and 62% had an initial BMI that was categorized as obese. Patients with a high ACEs score were more likely to have a BMI in the obese category compared with those in the low-risk group with an odds ratio of 1.34 (95% CI [0.7907-2.2798], p = 0.275). CONCLUSION: Maternal obesity is a well-known risk factor for numerous adverse obstetrical and neonatal outcomes. While the CDC reported a national prepregnancy obesity rate of 29.0% in 2019, our patients were 2.14 times more likely to be obese. Obesity was more prevalent in women with high ACEs scores. Safety net hospitals should be cognizant of marked increase in obesity in their obstetrical patients, especially those with high ACEs scores, and develop interventions that incorporate trauma-informed care. CI - (c) The Author(s) 2026. Published by Mary Ann Liebert (NY), LLC. FAU - Goforth, Michelle AU - Goforth M AD - University of Arizona College of Medicine, Phoenix, Arizona, USA. FAU - Brady, Sarah R AU - Brady SR AD - University of Arizona College of Medicine, Phoenix, Arizona, USA. FAU - Chambliss, Linda R AU - Chambliss LR AUID- ORCID: 0000-0003-1518-9240 AD - University of Arizona College of Medicine, Phoenix, Arizona, USA. AD - Department of Obstetrics and Gynecology, Creighton University School of Medicine, Phoenix Regional Campus, Nebraska, USA. AD - Department of Obstetrics and Gynecology, Valleywise Health Center, Phoenix, Arizona, USA. LA - eng PT - Journal Article DEP - 20260531 PL - United States TA - Womens Health Rep (New Rochelle) JT - Women's health reports (New Rochelle, N.Y.) JID - 101768931 PMC - PMC13421971 OTO - NOTNLM OT - ACES score OT - adverse childhood events OT - childhood trauma OT - obesity OT - pregnancy COIS- No competing financial interests exist. EDAT- 2026/08/01 06:35 MHDA- 2026/08/01 06:36 PMCR- 2026/05/31 CRDT- 2026/08/01 06:01 PHST- 2025/12/04 00:00 [accepted] PHST- 2026/08/01 06:36 [medline] PHST- 2026/08/01 06:35 [pubmed] PHST- 2026/08/01 06:01 [entrez] PHST- 2026/05/31 00:00 [pmc-release] AID - 10.1177_26884844261445331 [pii] AID - 10.1177/26884844261445331 [doi] PST - epublish SO - Womens Health Rep (New Rochelle). 2026 May 31;7:26884844261445331. doi: 10.1177/26884844261445331. eCollection 2026 Jan-Dec. PMID- 42538742 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20260813 IS - 2090-2735 (Electronic) IS - 2090-2727 (Print) IS - 2090-2727 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Associations Between Potential Listeria monocytogenes Exposure During Pregnancy and Infant Outcomes at Birth and Infant Delivery Resource Use: A Cross-Sectional Analysis in Australian Women. PG - e7824916 LID - 10.1155/jp/7824916 [doi] LID - 7824916 AB - Pregnant women are at higher risk of contracting listeriosis, which can lead to serious perinatal complications. This study evaluated associations between Listeria monocytogenes exposure, infant perinatal outcomes, and hospital resource use in a cohort of 1604 Australian mother-infant dyads. Maternal L. monocytogenes exposure was estimated from self-reported intake of foods from a validated food frequency questionnaire that potentially harbor L. monocytogenes. Infant outcomes obtained from hospital medical records included birth mode, preterm birth, birthweight, and admission to special care nursery (SCN)/neonatal intensive care unit (NICU). Infant hospital resource use was measured by infant length of stay (LOS), LOS in SCN/NICU, and days excluding SCN/NICU. Multinomial, negative binomial, and hurdle models, were performed to examine Listeria Food Exposure Score (LFES) associations with infant outcomes, total LOS, and LOS excluding and within SCN/NICU. All models were adjusted for covariates including smoking, parity, maternal age, BMI, and SEIFA IRSAD decile. Mean (SD) maternal age was 32.0 (5.0) years, and median (IQR) gestation was 39.0 (38.1, 40.0) weeks. Although adjusted results showed a statistically significant association between LFES and reduced infant LOS excluding SCN/NICU (beta = 0.99; 95% CI: 0.979, 0.998, p < 0.03), the effect size was minimal, with minor clinical significance. There were no significant associations with infant birth mode, preterm birth, low birthweight, size for gestational age, macrosomia, admission to NICU/SCN, total LOS in hospital, and SCN/NICU (all p > 0.05). Future research should explore these associations among ethnically diverse women at earlier stage of pregnancy and include the assessment of food safety practices in the analyses. CI - Copyright (c) 2026 Kee June Ooi et al. Journal of Pregnancy published by John Wiley & Sons Ltd. FAU - Ooi, Kee June AU - Ooi KJ AUID- ORCID: 0000-0002-1564-9799 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Fenton, Sasha AU - Fenton S AUID- ORCID: 0000-0002-4611-5810 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Taylor, Rachael AU - Taylor R AUID- ORCID: 0000-0002-1895-4123 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Hinwood, Madeleine AU - Hinwood M AUID- ORCID: 0000-0002-2225-973X AD - Data Science, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. FAU - Pannu, Poonam Kaur AU - Pannu PK AUID- ORCID: 0009-0006-0724-4683 AD - The Kids Research Institute Australia, Nedlands, Western Australia, Australia. AD - Curtin University, Bentley, Western Australia, Australia, curtin.edu.au. FAU - Hutchesson, Melinda AU - Hutchesson M AUID- ORCID: 0000-0002-1851-0661 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Collins, Clare E AU - Collins CE AUID- ORCID: 0000-0003-3298-756X AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. LA - eng GR - Commonwealth Government of Australia/ GR - Paul Ramsay Foundation/ GR - Joondalup Health Campus/ GR - Telethon Perth Children's Hospital Research Fund/ GR - Hunter Medical Research Institute/ GR - APP2009340/National Health and Medical Research Council/ PT - Journal Article PL - United States TA - J Pregnancy JT - Journal of pregnancy JID - 101553823 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Infant, Newborn MH - Adult MH - Cross-Sectional Studies MH - *Listeria monocytogenes MH - Australia/epidemiology MH - *Listeriosis/epidemiology MH - *Pregnancy Complications, Infectious/epidemiology/microbiology MH - Pregnancy Outcome/epidemiology MH - Premature Birth/epidemiology MH - Length of Stay/statistics & numerical data MH - Intensive Care Units, Neonatal/statistics & numerical data MH - Birth Weight PMC - PMC13428182 OTO - NOTNLM OT - Listeria monocytogenes OT - ORIGINS OT - birth outcomes OT - hospital resource use OT - infant outcomes OT - listeriosis COIS- The authors declare no conflicts of interest. EDAT- 2026/08/01 06:35 MHDA- 2026/08/01 06:36 PMCR- 2026/07/31 CRDT- 2026/08/01 02:02 PHST- 2026/02/18 00:00 [revised] PHST- 2025/04/08 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/08/01 06:36 [medline] PHST- 2026/08/01 06:35 [pubmed] PHST- 2026/08/01 02:02 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - JP7824916 [pii] AID - 10.1155/jp/7824916 [doi] PST - ppublish SO - J Pregnancy. 2026;2026(1):e7824916. doi: 10.1155/jp/7824916. PMID- 42538531 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260813 IS - 1476-072X (Electronic) IS - 1476-072X (Linking) VI - 25 IP - 1 DP - 2026 Jul 29 TI - Prevalence, spatial distribution, and determinants of anemia among under-five children in the Democratic Republic of Congo: evidence from the 2023-24 DHS. LID - 10.1186/s12942-026-00484-4 [doi] LID - 41 AB - BACKGROUND: Anemia among children under five remains a major public health problem in the Democratic Republic of Congo (DRC), affecting growth, cognitive development, and overall child health. We estimated the prevalence, spatial distribution, and determinants of anemia and identified high-risk geographic areas using multilevel and spatial analyses. METHODS: We analyzed data from 11,393 children aged 6-59 months from the 2023-24 Democratic Republic of Congo Demographic and Health Survey (DHS). Weighted prevalence estimates were calculated, and multilevel mixed-effects logistic regression was used to assess individual- and community-level determinants of anemia. We applied Moran's I, hotspot detection, Kriging interpolation, and SaTScan analyses to identify high-risk areas. Model performance was evaluated using AIC, BIC, and log-likelihood ratio tests to ensure the results were reliable. RESULTS: Overall, 51.7% of children (95% CI: 49.5%-53.9%) were anemic, most cases were mild (25.6%) or moderate (25.0%), while severe anemia was rare (1.1%). Prevalence was highest among infants 0-5 months (56.2%) and boys (52.5%) than girls (50.8%). Key risk factors for anemia included wasting (AOR = 1.29), malaria infection (AOR = 1.21), high community malaria risk (AOR = 1.42), and low altitude (AOR = 1.39). Children were less likely to be anemic if their mothers were overweight (AOR = 0.66), if they came from wealthier households (AOR = 0.77), or if they lived in moderately sized families (AOR = 0.84). Spatial analysis revealed high-prevalence areas in Haut-Lomami, Maniema, and Tshuapa, whereas lower prevalence was seen in Haut-Uele and Nord Ubangi. CONCLUSION: Anemia among under-five children in the DRC is geographically clustered and influenced by both individual- and community-level factors. Targeted and integrated interventions focusing on malaria prevention, nutrition, and maternal health are needed in high-burden areas. CI - (c) 2026. The Author(s). FAU - Yewodiaw, Thomas Kidanemariam AU - Yewodiaw TK AUID- ORCID: 0009-0009-1491-1044 AD - International Medical Corps, Amhara Region Emergency Operation Center, Gondar Field Office, Gondar, Ethiopia. thomaskmariam28@gmail.com. AD - Department of Epidemiology and Biostatistics, Institute of public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. thomaskmariam28@gmail.com. FAU - Endalew, Helen Lamesgin AU - Endalew HL AD - Department of Surgical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Getnet, Mihret AU - Getnet M AD - Department of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. AD - Department of Epidemiology and Biostatistics, Institute of public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Getahun, Amare Belete AU - Getahun AB AD - Department of Anesthesia, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Mengstie, Tiget Ayelgn AU - Mengstie TA AD - Department of Medical Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Enyew, Engidaw Fentahun AU - Enyew EF AD - Department of Human Anatomy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. AD - Department of Reproductive Health, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia. FAU - Endale, Hiwot Tezera AU - Endale HT AD - Department of Medical Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Asefa, Tseganesh AU - Asefa T AD - Armauer Hansen Research Institute, Addis Ababa, Ethiopia. FAU - Bitewa, Mequanent Dessie AU - Bitewa MD AD - Department of Public Health, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia. LA - eng PT - Journal Article DEP - 20260729 PL - England TA - Int J Health Geogr JT - International journal of health geographics JID - 101152198 SB - IM MH - Humans MH - Democratic Republic of the Congo/epidemiology MH - *Anemia/epidemiology/diagnosis MH - Infant MH - Female MH - Child, Preschool MH - Prevalence MH - Male MH - *Health Surveys/methods MH - Risk Factors MH - Spatial Analysis PMC - PMC13428445 OTO - NOTNLM OT - Anemia OT - DHS OT - Democratic Republic of Congo OT - Hotspot analysis OT - Multilevel analysis OT - Spatial distribution OT - Under-five children COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/01 00:36 MHDA- 2026/08/01 00:37 PMCR- 2026/07/29 CRDT- 2026/07/31 23:33 PHST- 2025/12/11 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/01 00:37 [medline] PHST- 2026/08/01 00:36 [pubmed] PHST- 2026/07/31 23:33 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1186/s12942-026-00484-4 [pii] AID - 484 [pii] AID - 10.1186/s12942-026-00484-4 [doi] PST - epublish SO - Int J Health Geogr. 2026 Jul 29;25(1):41. doi: 10.1186/s12942-026-00484-4. PMID- 42538110 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260821 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 7 DP - 2026 Jul 31 TI - Non-pharmacological interventions for lactational mastitis: a systematic review and meta-analysis protocol. PG - e120579 LID - 10.1136/bmjopen-2026-120579 [doi] LID - e120579 AB - BACKGROUND: Lactational mastitis is a common inflammatory condition that can adversely affect maternal well-being and is associated with early cessation of breastfeeding. Although antibiotics and analgesics are widely used in clinical practice, concerns regarding antimicrobial resistance and potential effects on the infant microbiome have prompted increasing interest in non-pharmacological approaches. A range of physical and biological interventions, including probiotics, therapeutic ultrasound, acupuncture and manual therapies, have been investigated; however, the comparative effectiveness and safety of these interventions remain unclear. This study aims to systematically evaluate the efficacy and safety of non-pharmacological interventions for lactational mastitis. METHODS AND ANALYSIS: This protocol is reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. We will systematically search PubMed, Embase, Web of Science, the Cochrane Library, CNKI, Wanfang, VIP and SinoMed as well as relevant trial registries from database inception to March 2026.We will include randomised controlled trials enrolling adult lactating women diagnosed with mastitis. Eligible studies will compare non-pharmacological interventions with usual care, placebo or pharmacological treatments. Interventions involving pharmacologically active agents will be excluded.Two reviewers will independently perform study selection, data extraction and risk of bias assessment using the Cochrane RoB 2 tool. The primary outcome will be resolution of mastitis, defined as the return of body temperature to normal (<37 degrees C) and resolution of localised breast symptoms (eg, pain, erythema and swelling). Secondary outcomes will include inflammatory markers (eg, C-reactive protein), pain intensity (measured using the Visual Analogue Scale or similar validated scales), incidence of adverse events, complete blood count parameters, time to symptom resolution or normalisation of body temperature, incidence of breast abscess and breastfeeding continuation rates.Meta-analysis will be conducted, where appropriate, using random-effects models. Continuous outcomes will be summarised using mean differences or standardised mean differences, and dichotomous outcomes using risk ratios, all with 95% CIs. Statistical heterogeneity will be assessed using the I(2) statistic. Subgroup and sensitivity analyses will be performed to explore potential sources of heterogeneity. Publication bias will be assessed using funnel plots and Egger's test when sufficient studies are available. The certainty of evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation（GRADE）approach. ETHICS AND DISSEMINATION: Ethical approval is not required for this study as it is based on published data. The findings will be disseminated through peer-reviewed publications and conference presentations. PROSPERO REGISTRATION NUMBER: CRD420261347640. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Zhang, Siyuan AU - Zhang S AUID- ORCID: 0009-0003-8378-2887 AD - Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. FAU - Ren, Yuehan AU - Ren Y AUID- ORCID: 0009-0008-7225-2908 AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. FAU - Zhang, Qiong AU - Zhang Q AD - Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. FAU - Fan, Yingyi AU - Fan Y AD - Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China fan38898901@126.com. LA - eng PT - Journal Article DEP - 20260731 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - *Mastitis/therapy MH - Systematic Reviews as Topic MH - *Lactation MH - Meta-Analysis as Topic MH - Breast Feeding MH - Research Design MH - Probiotics/therapeutic use MH - Acupuncture Therapy PMC - PMC13436078 OTO - NOTNLM OT - Breast surgery OT - Meta-Analysis OT - Protocols & guidelines OT - Systematic Review COIS- Competing interests: None declared. EDAT- 2026/08/01 00:36 MHDA- 2026/08/01 00:37 PMCR- 2026/07/31 CRDT- 2026/07/31 21:03 PHST- 2026/08/01 00:37 [medline] PHST- 2026/08/01 00:36 [pubmed] PHST- 2026/07/31 21:03 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - bmjopen-2026-120579 [pii] AID - 10.1136/bmjopen-2026-120579 [doi] PST - epublish SO - BMJ Open. 2026 Jul 31;16(7):e120579. doi: 10.1136/bmjopen-2026-120579. PMID- 42537543 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 151 DP - 2026 Nov TI - Total energy expenditure and its components in healthy young adults from Southwest China using doubly labeled water, indirect calorimetry, accelerometry, and energy intake. PG - 113350 LID - S0899-9007(26)00258-3 [pii] LID - 10.1016/j.nut.2026.113350 [doi] AB - BACKGROUND: Energy requirement (ER) in young adults is commonly estimated from predicted resting metabolic rate (RMR) and assumed physical activity level (PAL). These assumptions may not fully reflect free-living total energy expenditure (TEE) in healthy young adults from Southwest China with low-activity daily routines. OBJECTIVE: This study compared doubly labeled water (DLW)-measured TEE with factorial TEE based on measured RMR and with equation-estimated TEE, interpreted as estimated ER, derived from Chinese and FAO/WHO/UNU RMR prediction equations. Measured and predicted RMR, TEE partitioning, and energy intake-TEE agreement were also examined. METHODS: Twenty healthy adults aged 18-30 years from Southwest China completed a 7-d free-living assessment. TEE was measured using DLW, and RMR was measured by indirect calorimetry. Physical activity was assessed using triaxial accelerometry with activity records. Dietary intake was measured using the duplicate-portion method and laboratory analysis. PAL was calculated as TEE/RMR, and thermic effect of food (TEF) was estimated by difference. Agreement was further evaluated using Bland-Altman analysis. RESULTS: DLW-measured TEE was 2039.63 +/- 304.43 kcal/d and did not differ significantly from factorial TEE or equation-estimated TEE derived using the Chinese and FAO/WHO/UNU equations. However, Chinese equation-predicted RMR was significantly lower than measured RMR (1584.29 +/- 232.97 kcal/d, p < 0.05), whereas FAO/WHO/UNU-predicted RMR was comparable with measured RMR. Measured PAL was low (1.29 +/- 0.12), and RMR, physical activity energy expenditure (PAEE), and TEF accounted for 78.0%, 12.9%, and 9.1% of TEE, respectively. Energy intake was broadly comparable with DLW-measured TEE at the group level, although Bland-Altman analysis indicated individual-level variability. CONCLUSIONS: Equation-estimated TEE, interpreted as estimated ER, was broadly comparable with DLW-measured TEE at the group level. However, this apparent agreement depended on both RMR prediction and PAL assumptions. The findings support component-based evaluation of ER in young Chinese adults, with attention to RMR, PAL, PAEE, TEF, FQ, and energy balance. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Nie, Xiangzhen AU - Nie X AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China; Guangxi Engineering Research Center for Large-Scale Preparation, Nutrition and Hygiene of Guangxi Cuisine, Guilin, Guangxi, China. FAU - Liu, Ronghan AU - Liu R AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China; Guangxi Engineering Research Center for Large-Scale Preparation, Nutrition and Hygiene of Guangxi Cuisine, Guilin, Guangxi, China. FAU - Yan, Xiantao AU - Yan X AD - Guangdong Key Laboratory of Functional Substances and Health Products from Medicinal Edible Resources, Hanshan Normal University, Chaozhou, Guangdong, China. Electronic address: yanyang214@126.com. FAU - Tian, Ying AU - Tian Y AD - School of Basic Medical Sciences & School of Public Health, Yangzhou University, Yangzhou, Jiangsu, China. FAU - Al-Dalali, Sam AU - Al-Dalali S AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China; Guangxi Engineering Research Center for Large-Scale Preparation, Nutrition and Hygiene of Guangxi Cuisine, Guilin, Guangxi, China. FAU - Jiang, Mengchao AU - Jiang M AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China. FAU - Ni, Xinling AU - Ni X AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China. LA - eng PT - Journal Article DEP - 20260703 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - *Energy Metabolism/physiology MH - Calorimetry, Indirect/methods MH - Adult MH - Young Adult MH - Female MH - *Energy Intake/physiology MH - China MH - Basal Metabolism MH - Adolescent MH - Male MH - Accelerometry/methods MH - Exercise MH - Nutritional Requirements OTO - NOTNLM OT - Calorimetry OT - Energy intake OT - Energy metabolism OT - Resting metabolic rate OT - Validation studies OT - Young adults OT - indirect COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/01 00:36 MHDA- 2026/08/25 23:33 CRDT- 2026/07/31 18:07 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/25 23:33 [medline] PHST- 2026/08/01 00:36 [pubmed] PHST- 2026/07/31 18:07 [entrez] AID - S0899-9007(26)00258-3 [pii] AID - 10.1016/j.nut.2026.113350 [doi] PST - ppublish SO - Nutrition. 2026 Nov;151:113350. doi: 10.1016/j.nut.2026.113350. Epub 2026 Jul 3. PMID- 42537500 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 153 DP - 2026 Sep TI - Moderate MIND diet adherence and positive correlation between weekly egg intake and skin carotenoid scores in college students. PG - 78-85 LID - S0271-5317(26)00086-2 [pii] LID - 10.1016/j.nutres.2026.07.003 [doi] AB - Adherence to the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet, which emphasizes fruit and vegetables and thereby carotenoid intake, is associated with better cognitive health in older adults. However, as neurodegeneration is thought to progress over decades, adopting such a dietary pattern in young adulthood may help prevent its initiation and progression. The aim of this study was to determine whether scores on the MIND diet screener predict skin carotenoid scores in college students, as a measure of construct validity. Participants completed a modified 14-item MIND diet screener and an item on weekly egg intake. Skin carotenoids were assessed using pressure-mediated reflective spectroscopy by Veggie Meter, and the data were analyzed using Pearson correlations. Participants (n = 293; 62.5% female; 20.0 +/- 2.0 years) scored 8.3 +/- 2.1 on the screener, indicating suboptimal adherence to the MIND dietary pattern, and skin carotenoid scores averaged 305 +/- 90. MIND diet screener score predicted skin carotenoid score (r = 0.327; CI 0.220-0.425; P < .001), strengthened by adding the egg intake item (r = 0.353; CI 0.249-0.450; P < .001), and was highest in those consuming >/=7 eggs/wk (r = 0.50). Two dietary patterns emerged from clustering analysis, differentiated by intakes of leafy greens, other vegetables, berries, beans, and nuts. In conclusion, the MIND diet screener score predicts skin carotenoid content in young adults, supporting the tool's validity; however, frequent egg intake strongly moderated the relationship. Egg intake should be considered when interpreting skin carotenoid scores and included in future iterations of the MIND diet screener. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Hill, Chloe AU - Hill C AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Foster, Victoria R AU - Foster VR AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Patel, Arya B AU - Patel AB AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Ribay, Gabriel D AU - Ribay GD AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Sadlo, Margaret K AU - Sadlo MK AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Senthilkumar, Neha AU - Senthilkumar N AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Moreno, Melissa L AU - Moreno ML AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Colee, James AU - Colee J AD - Institute of Food and Agricultural Sciences (IFAS) Statistics Department, University of Florida, Gainesville, FL, USA. FAU - Dahl, Wendy J AU - Dahl WJ AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. Electronic address: wdahl@ufl.edu. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 RN - 36-88-4 (Carotenoids) SB - IM MH - Humans MH - Female MH - *Carotenoids/analysis MH - Male MH - *Skin/chemistry MH - Students MH - *Eggs MH - Young Adult MH - *Diet, Mediterranean MH - Vegetables MH - Fruit MH - Universities MH - Adolescent MH - *Feeding Behavior MH - Adult MH - Diet MH - *Patient Compliance OTO - NOTNLM OT - Carotenoids OT - Diet OT - Diet surveys OT - Egg yolk OT - Mediterranean-DASH diet intervention for neurodegenerative delay OT - Plant-based OT - Reflection spectroscopy COIS- Author declarations All authors declare that the research was conducted without commercial or financial relationships and that there is no conflict of interest. EDAT- 2026/08/01 00:36 MHDA- 2026/08/26 23:35 CRDT- 2026/07/31 18:06 PHST- 2026/02/16 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/08/26 23:35 [medline] PHST- 2026/08/01 00:36 [pubmed] PHST- 2026/07/31 18:06 [entrez] AID - S0271-5317(26)00086-2 [pii] AID - 10.1016/j.nutres.2026.07.003 [doi] PST - ppublish SO - Nutr Res. 2026 Sep;153:78-85. doi: 10.1016/j.nutres.2026.07.003. Epub 2026 Jul 8. PMID- 42536949 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 0043-5147 (Print) IS - 0043-5147 (Linking) VI - 79 IP - 6 DP - 2026 TI - Diagnostic value of lateral cephalometric parameters in determining vertical and horizontal maxillofacial growth patterns. PG - 1312-1322 LID - 10.36740/WLek/222584 [doi] AB - OBJECTIVE: Aim: To assess the diagnostic value of qualitative and quantitative lateral cephalometric parameters in determining vertical, horizontal, and neutral maxillofacial growth patterns in patients with orthodontic pathology. PATIENTS AND METHODS: Materials and Methods: The study included 292 lateral cephalograms of patients aged 5 to 50 years who sought orthodontic consultation. Eleven quantitative cephalometric parameters were analysed in the full sample. In a randomised subgroup of 160 cephalograms, seven additional qualitative parameters were assessed. Growth pattern determination was performed using an integrated approach based on the absolute majority of diagnostic signs. In addition, 134 cephalograms were independently evaluated by 34 orthodontic trainees using qualitative characteristics only. The diagnostic performance of each parameter was assessed using balanced accuracy, sensitivity, specificity, and positive predictive value. RESULTS: Results: Among 292 patients, 121 had a neutral growth pattern, 103 a vertical pattern, and 68 a horizontal pattern. Evaluation based only on qualitative signs resulted in correct classification in 60.45% of cases on average. Among quantitative parameters, angleN-Go-Me demonstrated the highest diagnostic performance, with a positive predictive value of 82.9%, followed by angleAr-Go-Me and anglePn-MP. Among qualitative parameters, the mandibular angle, condylar process height, and contour of the lower mandibular border showed the highest diagnostic value. CONCLUSION: Conclusions: Quantitative cephalometric parameters, particularly angleN-Go-Me, are more diagnostically reliable than isolated qualitative assessment for determining maxillofacial growth patterns. A combined approach may improve diagnostic accuracy in orthodontic treatment planning. FAU - Drohomyretska, Myroslava S AU - Drohomyretska MS AD - SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE. FAU - Tkachenko, Yulia V AU - Tkachenko YV AD - SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE. FAU - Garmash, Olga V AU - Garmash OV AD - KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE. LA - eng PT - Journal Article PL - Poland TA - Wiad Lek JT - Wiadomosci lekarskie (Warsaw, Poland : 1960) JID - 9705467 SB - IM MH - Humans MH - *Cephalometry/methods MH - Female MH - Child MH - *Maxillofacial Development/physiology MH - Male MH - Adolescent MH - Adult MH - Middle Aged MH - Child, Preschool MH - Young Adult MH - Sensitivity and Specificity OTO - NOTNLM OT - cephalometry OT - craniofacial growth OT - orthodontics OT - vertical dimension EDAT- 2026/07/31 18:35 MHDA- 2026/07/31 18:36 CRDT- 2026/07/31 15:42 PHST- 2026/07/31 18:36 [medline] PHST- 2026/07/31 18:35 [pubmed] PHST- 2026/07/31 15:42 [entrez] AID - 10.36740/WLek/222584 [doi] PST - ppublish SO - Wiad Lek. 2026;79(6):1312-1322. doi: 10.36740/WLek/222584. PMID- 42536608 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Applications of the Behavior Change Wheel in promoting physical activity among children and adolescents: A scoping review. PG - e0354697 LID - 10.1371/journal.pone.0354697 [doi] LID - e0354697 AB - BACKGROUND: Physical inactivity among children and adolescents remains a major global public health concern, yet the ways in which behavioral theory is applied to inform physical activity (PA) interventions are often insufficiently described. The Behavior Change Wheel (BCW) model provides a systematic framework for linking behavioral determinants to intervention content, but its application in PA promotion for this population has not been comprehensively mapped. METHODS: This scoping review was conducted in accordance with the Joanna Briggs Institute methodology and reported following the PRISMA-ScR guideline. Seven electronic databases were searched for studies published since 2011 that explicitly applied the BCW to promote PA among children and adolescents. Data were charted on study characteristics, targeted components of the Capability, Opportunity, and Motivation-Behavior (COM-B) model, BCW intervention functions, behavior change techniques, and implementation outcomes. RESULTS: Fifteen studies met the inclusion criteria. Most applications focused on intervention development, co-design, or feasibility rather than effectiveness evaluation. Psychological capability and reflective motivation were the most frequently targeted COM-B components, and education, training, and enablement were the dominant intervention functions. Commonly used behavior change techniques included goal setting, action planning, self-monitoring, feedback, and social support. Functions involving coercion or restriction were rarely used. Reporting of implementation outcomes was inconsistent, with limited attention to reach, penetration, and sustainability. CONCLUSIONS: In studies using the BCW framework, PA interventions for children and adolescents predominantly emphasize individual-level self-regulation strategies, with less focus on opportunity-level change and implementation sustainability. Greater transparency in theoretical mapping and stronger integration of implementation considerations are needed to enhance the translation of theory-based interventions into practice. CI - Copyright: (c) 2026 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Huang, Zheng AU - Huang Z AD - Department of Physical Education, Changzhou Institute of Technology, Changzhou, China. FAU - Fang, Shuguang AU - Fang S AD - Department of Physical Education, Changzhou Institute of Technology, Changzhou, China. FAU - Peng, Sanying AU - Peng S AUID- ORCID: 0000-0001-6007-7403 AD - Department of Physical Education, Hohai University, Nanjing, China. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260731 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Exercise/psychology MH - *Health Promotion/methods MH - Motivation MH - *Health Behavior PMC - PMC13426998 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/31 18:35 MHDA- 2026/07/31 18:36 PMCR- 2026/07/31 CRDT- 2026/07/31 13:24 PHST- 2026/01/23 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/31 18:36 [medline] PHST- 2026/07/31 18:35 [pubmed] PHST- 2026/07/31 13:24 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - PONE-D-26-02954 [pii] AID - 10.1371/journal.pone.0354697 [doi] PST - epublish SO - PLoS One. 2026 Jul 31;21(7):e0354697. doi: 10.1371/journal.pone.0354697. eCollection 2026. PMID- 42534148 OWN - NLM STAT- Publisher LR - 20260923 IS - 1091-367X (Print) IS - 1532-7841 (Electronic) IS - 1091-367X (Linking) DP - 2026 Jul 16 TI - Measurement Reactivity to Hip-Worn Accelerometry Among Adolescent Females: A Concurrent Wear Approach. LID - 10.1080/1091367x.2026.2704743 [doi] AB - Device-based measurement of physical activity (PA) is crucial for valid research, but reactivity to these devices can undermine validity. Inconsistent findings in prior reactivity research warrant unique approaches among diverse populations, including those habituated to wearing another device. We aimed to estimate reactivity to ActiGraph GT3X+ via concurrent Fitbit Inspire HR wear among Latina adolescents using a person-day matched cross-sectional design. Fitbit data estimated steps, moderate-vigorous PA, light PA, and sedentary time for all days in the 2 weeks preceding and following matched ActiGraph wear days. Linear models estimated the association of ActiGraph wear day with activity after adjustment for covariates. There were 2987 total days across 107 participants, ~35% classified as ActiGraph wear days. Steps statistically significantly differed (p = .0499) with ActiGraph wear days corresponding to 248 greater average steps. Measurement reactivity to ActiGraph may impact steps among adolescent females. Future research could benefit from concurrent wear strategies if feasible. FAU - Carson, Jacob AU - Carson J AD - Herbert Wertheim School of Public Health and Human Longevity, University of California San Diego, La Jolla, California, USA. FAU - Castro, Esmeralda AU - Castro E AD - Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA. FAU - Higgins, Michael AU - Higgins M AD - EPARC, University of California San Diego, La Jolla, California, USA. FAU - Godino, Job AU - Godino J AD - Laura Rodriguez Research Institute, Family Health Centers of San Diego, San Diego, California, USA. FAU - Larsen, Britta AU - Larsen B AD - Herbert Wertheim School of Public Health and Human Longevity, University of California San Diego, La Jolla, California, USA. LA - eng GR - R01 NR017876/NR/NINR NIH HHS/United States GR - T32 HL079891/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260716 PL - United States TA - Meas Phys Educ Exerc Sci JT - Measurement in physical education and exercise science JID - 100893864 PMC - PMC13419367 MID - NIHMS2196539 OTO - NOTNLM OT - Physical activity OT - accelerometry OT - consumer wearables OT - free-living activity OT - pedometry COIS- Disclosure statement No potential conflict of interest was reported by the author(s). EDAT- 2026/07/31 06:36 MHDA- 2026/07/31 06:36 PMCR- 2026/07/31 CRDT- 2026/07/31 05:15 PHST- 2026/07/31 06:36 [medline] PHST- 2026/07/31 06:36 [pubmed] PHST- 2026/07/31 05:15 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.1080/1091367x.2026.2704743 [doi] PST - aheadofprint SO - Meas Phys Educ Exerc Sci. 2026 Jul 16:10.1080/1091367x.2026.2704743. doi: 10.1080/1091367x.2026.2704743. PMID- 42533614 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260903 IS - 1545-5017 (Electronic) IS - 1545-5009 (Linking) VI - 73 IP - 10 DP - 2026 Oct TI - Navigating the Planning and Initiation of a First Prospective Clinical Trial Through a Regional Pediatric Oncology Consortium Within the Middle East, Africa, and Asia-A Roadmap. PG - e70556 LID - 10.1002/1545-5017.70556 [doi] AB - BACKGROUND: Prospective pediatric oncology clinical trials remain scarce across low- and middle-income countries (LMICs). We developed the first multicountry prospective clinical trial within the Pediatric Oncology East and Mediterranean (POEM) group. Localized osteosarcoma was selected due to heterogeneous real-world management, including alternative regimens in settings where methotrexate administration is not feasible. This descriptive report details the feasibility of a regionally coordinated, resource-adapted clinical trial across diverse LMIC settings. METHODS: We describe the planning, capacity assessment, training, governance, and activation of POEM-OS, a pragmatic two-arm prospective cohort study evaluating MAP- and OS99-based therapy for localized osteosarcoma. Preparation included a structured capacity-mapping exercise across regional centers to assess clinical resources, research, and regulatory structures. The approach also encompassed designing a training program and communication through a structured study coordination team. RESULTS: A total of 27 centers from 10 countries expressed intent to participate. A 12-week virtual training curriculum was implemented for principal investigator and clinical research coordinator dyads, followed by an in-person regional workshop. Eventually, 21 centers (8 countries) proceeded to study activation. Major barriers included heterogeneity in chemotherapy administration, high staff turnover, and variability in timelines to study-agreement execution. Adaptive solutions included permanently accessible online training modules, simplified chemotherapy dosing, and harmonized toxicity grading. Centralized REDCap platforms enabled regional data sharing. By February 2026, the study had opened at 16 centers, with 21 patients enrolled. CONCLUSION: POEM-OS demonstrates that a regionally directed, resource-adapted clinical trial platform is feasible across diverse LMIC settings and establishes a foundation for sustainable regional clinical research infrastructure. CI - (c) 2026 Wiley Periodicals LLC. FAU - Papyan, Ruzanna AU - Papyan R AUID- ORCID: 0000-0003-1949-6280 AD - Department of Hematology and Pediatric Oncology, Yerevan State Medical University, Yerevan, Armenia. AD - Yeolyan Hematology and Oncology Center, Yerevan, Armenia. AD - Immune Oncology Research Institute, Yerevan, Armenia. FAU - Ghamloush, Farah AU - Ghamloush F AD - Department of Anatomy, Cell Biology and Physiological Sciences and POEM Central Office, American University of Beirut, Beirut, Lebanon. FAU - Sidhom, Iman AU - Sidhom I AD - Department of Pediatric Oncology, National Cancer Institute, Cairo University and Children's Cancer Hospital Egypt, Cairo, Egypt. FAU - Belgaumi, Asim AU - Belgaumi A AUID- ORCID: 0000-0002-0135-7509 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Nasr, Rihab AU - Nasr R AD - Department of Anatomy, Cell Biology and Physiological Sciences and POEM Central Office, American University of Beirut, Beirut, Lebanon. FAU - Sultan, Iyad AU - Sultan I AD - King Hussein Cancer Center, Amman, Jordan. FAU - Tamamyan, Gevorg AU - Tamamyan G AD - Department of Hematology and Pediatric Oncology, Yerevan State Medical University, Yerevan, Armenia. AD - Immune Oncology Research Institute, Yerevan, Armenia. FAU - Radhakrishnan, Venkatraman AU - Radhakrishnan V AUID- ORCID: 0000-0002-7557-5816 AD - Department of Medical Oncology, Cancer Institute (W.I.A), Chennai, India. FAU - Rodriguez-Galindo, Carlos AU - Rodriguez-Galindo C AUID- ORCID: 0000-0002-2360-8946 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Jeha, Sima AU - Jeha S AUID- ORCID: 0000-0003-2835-5869 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Santana, Victor M AU - Santana VM AUID- ORCID: 0000-0003-0320-5776 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Saab, Raya AU - Saab R AUID- ORCID: 0000-0001-5776-2303 AD - Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA. LA - eng GR - Programme for Advancing the Research Capacity/ GR - International Society of Paediatric Oncology/ GR - American Lebanese Syrian Associated Charities/ PT - Journal Article PT - Multicenter Study DEP - 20260731 PL - United States TA - Pediatr Blood Cancer JT - Pediatric blood & cancer JID - 101186624 SB - IM MH - Humans MH - Prospective Studies MH - Middle East MH - Child MH - *Clinical Trials as Topic MH - *Osteosarcoma/drug therapy MH - Asia MH - Africa MH - Resource-Limited Settings MH - *Bone Neoplasms/drug therapy MH - Developing Countries MH - Female MH - *Medical Oncology OTO - NOTNLM OT - clinical trial OT - global oncology OT - low- and middle-income countries (LMICs) OT - osteosarcoma OT - research capacity EDAT- 2026/07/31 06:36 MHDA- 2026/08/25 17:35 CRDT- 2026/07/31 03:13 PHST- 2026/06/14 00:00 [revised] PHST- 2026/04/15 00:00 [received] PHST- 2026/06/27 00:00 [accepted] PHST- 2026/08/25 17:35 [medline] PHST- 2026/07/31 06:36 [pubmed] PHST- 2026/07/31 03:13 [entrez] AID - 10.1002/1545-5017.70556 [doi] PST - ppublish SO - Pediatr Blood Cancer. 2026 Oct;73(10):e70556. doi: 10.1002/1545-5017.70556. Epub 2026 Jul 31. PMID- 42533515 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 1899-5276 (Print) IS - 1899-5276 (Linking) VI - 35 IP - 7 DP - 2026 Jul TI - Family and dietary risk factors associated with childhood sleep disorders: Evidence from a cross-sectional study in China. PG - 1235-1245 LID - 10.17219/acem/212573 [doi] AB - BACKGROUND: Childhood sleep disorders are common and are associated with familyand diet-related factors, such as parental snoring and unhealthy eating habits. However, culturally relevant studies remain limited, and existing research often overlooks weak correlations in large populations. OBJECTIVES: This study aimed to identify familyand diet-related risk factors for childhood sleep disorders in a Chinese population and to provide insights for prevention. MATERIAL AND METHODS: A cross-sectional study was conducted in Jinan, China, between January 2022 and December 2023, enrolling 845 children aged 1-7 years through convenience sampling. Sleep disorders were defined based on parent-reported symptoms (mouth breathing, habitual snoring, apnea, or gasping) using a validated questionnaire. Demographic, family, and dietary factors were collected. Associations were analyzed using multivariable logistic regression with stepwise selection based on the Akaike information criterion (AIC), adjusted for age, with subgroup analyses according to age (1-3, 4-5, and 6-7 years). Statistical significance was set at p < 0.05. RESULTS: Among the 845 children (mean age: 5.2 years), 192 (22.7%) had sleep disorders. Multivariable analysis showed that parental snoring (father: odds ratio (OR) = 2.20, 95% confidence interval (95% CI): 1.44-3.41; mother: OR = 1.76, 95% CI: 1.15-2.66), maternal education at the associate degree level (OR = 2.58, 95% CI: 1.27-5.66) or bachelor's degree level (OR = 2.44, 95% CI: 1.21-5.29), and children's preferences for fried foods (OR = 6.49, 95% CI: 2.51-17.40), meat (OR = 2.19, 95% CI: 1.43-3.35), and sweets (OR = 2.15, 95% CI: 1.31-3.51) were significant risk factors. Moderate sweet consumption (1-2 times/week: OR = 0.53, 95% CI: 0.29-0.95; 3-5 times/week: OR = 0.51, 95% CI: 0.27-0.94) was associated with a protective effect compared with daily consumption. CONCLUSIONS: Childhood sleep disorders were significantly associated with parental snoring, higher maternal educational attainment, and children's preferences for fried foods, meat, and sweets, whereas moderate sweet consumption appeared to have a protective effect. FAU - Zhang, Lifeng AU - Zhang L AD - The First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. FAU - Chen, Xiangjing AU - Chen X AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. FAU - Zhang, Xin AU - Zhang X AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. FAU - Yan, Ya AU - Yan Y AD - The First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. FAU - Wang, Renzhong AU - Wang R AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. LA - eng PT - Journal Article PL - Poland TA - Adv Clin Exp Med JT - Advances in clinical and experimental medicine : official organ Wroclaw Medical University JID - 101138582 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Risk Factors MH - Female MH - *Sleep Wake Disorders/epidemiology/etiology MH - China/epidemiology MH - Child, Preschool MH - Male MH - Child MH - *Diet/adverse effects MH - Infant MH - Feeding Behavior MH - Snoring MH - Surveys and Questionnaires OTO - NOTNLM OT - childhood sleep disorders OT - dietary habits OT - maternal education OT - parental snoring OT - risk factors EDAT- 2026/07/31 06:37 MHDA- 2026/07/31 12:39 CRDT- 2026/07/31 02:02 PHST- 2025/06/18 00:00 [received] PHST- 2025/10/14 00:00 [accepted] PHST- 2026/07/31 12:39 [medline] PHST- 2026/07/31 06:37 [pubmed] PHST- 2026/07/31 02:02 [entrez] AID - 10.17219/acem/212573 [doi] PST - ppublish SO - Adv Clin Exp Med. 2026 Jul;35(7):1235-1245. doi: 10.17219/acem/212573. PMID- 42532561 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260918 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 7 DP - 2026 Jul 30 TI - Vietnam Cerebral Palsy Register: protocol for co-design of a national register with people with lived experience of cerebral palsy. PG - e116376 LID - 10.1136/bmjopen-2026-116376 [doi] LID - e116376 AB - INTRODUCTION: Cerebral palsy (CP) is the most common physical disability in childhood. Although an estimated 60 000 children live with CP in Vietnam, there is no national register to systematically collect data on the prevalence, risk factors or clinical profile of CP or service access. This paper outlines the protocol for establishing the Vietnam Cerebral Palsy Register (VCPR), a national register which will be co-designed by researchers and clinicians in collaboration with the Cerebral Palsy Family Association of Vietnam (CPFAV). The VCPR aims to inform service planning, policy and research through comprehensive, community-informed data collection. METHODS AND ANALYSIS: The VCPR will be developed by a consumer-clinician-researcher partnership. Initially, the VCPR will harmonise and pool data from two sources: (1) a hospital-based cohort of 765 children with CP identified at the National Children's Hospital in Hanoi (NCH) in 2017, and (2) members of the CPFAV, comprising over 4300 children with CP aged <18 years from 63 CPFAV hubs across Vietnam. Subsequently, standardised data for inclusion in the VCPR will prospectively be collected on children newly diagnosed with CP at NCH and other healthcare settings and on children newly referred to CPFAV.Data will be collected using an adapted version of the Australian CP register questionnaire through a combination of structured caregiver interviews, clinical assessments using validated tools and medical record review. Key demographic variables and information on CP type, motor severity-using the Gross Motor Function Classification System or Manual Ability Classification System, associated impairments (eg, vision, hearing, intellectual disabilities), condition at birth, congenital or other infections, vaccination, educational and nutritional status of the child, access to rehabilitation and family-related factors such as monthly household income, parental education and occupation and maternal health during pregnancy will be collected. The VCPR will contribute data to the Global Low- and Middle-Income Country Cerebral Palsy Register. ETHICS AND DISSEMINATION: Ethics approval has been obtained from Vietnamese and Australian institutions, whose role is to provide ethical oversight and research governance for the PhD project supporting the VCPR. Written informed consent will be obtained from primary caregivers for data collection, secure storage, access to relevant health records, verification with health professionals and future research contact, with no identifiable data disclosed.Involvement of people with lived experience of CP is central to the VCPR and leaders and members of the CPFAV will contribute to co-design, governance, participant engagement and dissemination. Findings will be shared regularly with families, clinicians, policymakers and researchers through CPFAV communications, peer-reviewed publications, national and international conferences and the VCPR website to inform equitable service planning, policy and future research. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Khuc, Thi Hong Hanh AU - Khuc THH AUID- ORCID: 0000-0002-9421-5517 AD - School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, Queensland, Australia honghanhkhuc@gmail.com. AD - Faculty of Medical Technology, Phenikaa School of Medicine and Pharmacy, Phenikaa University, Hanoi, Viet Nam. FAU - Cao, Minh Chau AU - Cao MC AD - Faculty of Medical Technology, Phenikaa School of Medicine and Pharmacy, Phenikaa University, Hanoi, Viet Nam. FAU - Karim, Tasneem AU - Karim T AD - Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Dinh, Thi Lan Anh AU - Dinh TLA AD - Cerebral Palsy Family Association Vietnam, Hanoi, Viet Nam. FAU - Nguyen, Thi Huong Giang AU - Nguyen THG AD - Department of Rehabilitation, National Children's Hospital, Hanoi, Viet Nam. FAU - Nguyen, Thi Van Anh AU - Nguyen TVA AUID- ORCID: 0000-0002-3673-7288 AD - Department of Rehabilitation, National Children's Hospital, Hanoi, Viet Nam. FAU - Pham, Minh Chau AU - Pham MC AD - Faculty of Medical Technology, Phenikaa School of Medicine and Pharmacy, Phenikaa University, Hanoi, Viet Nam. FAU - Nguyen, Van Bang AU - Nguyen VB AD - Medical Faculty, Hoa Binh University, Hanoi, Viet Nam. FAU - Rawal, Lal AU - Rawal L AUID- ORCID: 0000-0003-1106-0108 AD - School of Health Medical and Applied Sciences, Central Queensland University, Sydney, New South Wales, Australia. AD - S.P.O.R.T. Research Cluster, Central Queensland University, Rockhampton, Queensland, Australia. FAU - Mcintyre, Sarah AU - Mcintyre S AD - Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Khandaker, Gulam AU - Khandaker G AUID- ORCID: 0000-0002-0661-4113 AD - National Centre for Immunisation Research and Surveillance, Westmead, New South Wales, Australia. AD - Central Queensland Public Health Unit, Central Queensland Hospital and Health Service, Rockhampton, Queensland, Australia. FAU - Elliott, Elizabeth Jane AU - Elliott EJ AUID- ORCID: 0000-0002-6501-5487 AD - Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Kid's Research, The Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. CN - Cerebral Palsy Family Association Vietnam LA - eng PT - Journal Article DEP - 20260730 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Cerebral Palsy/epidemiology MH - *Registries MH - Vietnam/epidemiology MH - Child MH - Adolescent MH - Child, Preschool MH - Female MH - Research Design MH - Male MH - Infant PMC - PMC13423169 OTO - NOTNLM OT - Community child health OT - Developmental neurology & neurodisability OT - Protocols & guidelines OT - REGISTRIES COIS- Competing interests: None declared. EDAT- 2026/07/31 00:38 MHDA- 2026/07/31 00:39 PMCR- 2026/07/30 CRDT- 2026/07/30 20:43 PHST- 2026/07/31 00:39 [medline] PHST- 2026/07/31 00:38 [pubmed] PHST- 2026/07/30 20:43 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - bmjopen-2026-116376 [pii] AID - 10.1136/bmjopen-2026-116376 [doi] PST - epublish SO - BMJ Open. 2026 Jul 30;16(7):e116376. doi: 10.1136/bmjopen-2026-116376. PMID- 42531751 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Ninety years apart: Comparing pediatric growth charts used in Australia in the 1930s against modern standards. PG - 782-787 LID - S0882-5963(26)00362-3 [pii] LID - 10.1016/j.pedn.2026.07.060 [doi] AB - BACKGROUND: Growth charts have evolved since their introduction in the 18th century, with various organizations refining them to reflect the growth patterns of the populations they serve. In this context, this study compared growth tables published in a 1930s Australian child-health text by Dr. Isie Ross with contemporary growth charts used in pediatric practice. MATERIALS AND METHODS: Values from Ross's historical growth tables were extracted and plotted against current standardized growth references for children (WHO and CDC). Both Wilcoxon signed-rank test and Bland-Altman analysis were used to assess agreement and differences between the two data sources. RESULTS: Growth patterns from the 1930s showed some similarity to those in modern charts, with relatively small variation across most age groups, suggesting broad stability in early childhood growth over time. Clinically, however, the findings indicate limited applicability of historical references for assessing overweight, with greater secular change and variability observed at the upper growth percentiles. Overall, this highlights population-level stability in growth trajectories but poor clinical interchangeability between historical and contemporary references. CONCLUSIONS: Historical growth data may be more consistent with contemporary standards than commonly assumed. Examining such texts can enhance awareness of early contributions to pediatric growth assessment and highlighting the continued relevance of foundational work in child health despite its limited clinical interchangeability with modern references. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Al-Motlaq, Mohammad A AU - Al-Motlaq MA AD - Department of Maternal Child and Family Health, Faculty of Nursing, The Hashemite University, Zarqa, Jordan. Electronic address: Mohammada_m@hu.edu.jo. FAU - Shields, Linda AU - Shields L AD - Honorary Professor, Faculty of Medicine, The University of Queensland, Queensland, Australia. Electronic address: l.e.shields@uq.edu.au. LA - eng PT - Comparative Study PT - Historical Article PT - Journal Article DEP - 20260730 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - *Growth Charts MH - Australia MH - Child MH - History, 20th Century MH - Child, Preschool MH - *Child Development/physiology MH - Infant MH - Female MH - Male MH - Reference Values MH - *Pediatrics/history MH - Infant, Newborn OTO - NOTNLM OT - Australia OT - Charts OT - Child health OT - Growth tables OT - History COIS- Declaration of competing interest MA is an associate editor at the JPN. EDAT- 2026/07/31 00:38 MHDA- 2026/09/07 23:34 CRDT- 2026/07/30 18:04 PHST- 2026/01/07 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/07/25 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/07/31 00:38 [pubmed] PHST- 2026/07/30 18:04 [entrez] AID - S0882-5963(26)00362-3 [pii] AID - 10.1016/j.pedn.2026.07.060 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:782-787. doi: 10.1016/j.pedn.2026.07.060. Epub 2026 Jul 30. PMID- 42531291 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260828 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Resilience factors, pain, and physical activity in adolescent chronic musculoskeletal pain: Design and protocol of a pilot phase 2 single-group, non-randomized clinical trial. PG - e0353010 LID - 10.1371/journal.pone.0353010 [doi] LID - e0353010 AB - INTRODUCTION: Chronic musculoskeletal pain (CMSKP) in adolescence is associated with physical, psychological, social, and academic impairment and increased risk for chronic pain in adulthood. Although physical activity interventions are an evidence-based approach for managing pediatric chronic pain, many adolescents with CMSKP avoid physical activity due to fear of increased pain, low confidence in physical functioning, and other pain-avoidance behaviors. Resilience-focused interventions targeting self-efficacy, motivation, and mental flexibility may improve engagement in valued activities despite pain. This study describes the design and protocol of the Pain REsilience Promotion for Youth (PREP-Y) intervention, a resilience-focused physical activity intervention for adolescents with CMSKP. METHODS AND ANALYSIS: This single-site, pilot phase 2, single-group, non-randomized clinical trial will enroll 40 adolescents aged 12-17 years with CMSKP from Nationwide Children's Hospital in Columbus, Ohio, USA. Participants complete questionnaires, objective physical functioning assessments, and physical activity monitoring using activPAL devices as baseline measures. Participants then complete 4 virtual resilience-focused intervention sessions targeting pain resilience, self-efficacy, motivation, and adaptive coping related to physical activity. Garmin watches are used to track activity during the intervention period. Follow-up assessments occur post-intervention and at 3 months post-intervention. Primary outcomes include feasibility and acceptability, assessed through recruitment, retention, attendance, intervention fidelity, and completion of study measures. Exploratory outcomes include physical activity, sedentary behavior, pain-related functioning, pain catastrophizing, kinesiophobia, self-efficacy, and resilience-related constructs. ETHICS AND DISSEMINATION: The study was approved by the Nationwide Children's Hospital Institutional Review Board. Findings will inform a future randomized clinical trial. This manuscript reflects protocol version 5.0 dated 23 March 2026. TRIAL REGISTRATION: ClinicalTrials.gov NCT06923891. CI - Copyright: (c) 2026 Logan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Logan, Faith AU - Logan F AUID- ORCID: 0009-0004-9662-114X AD - Behavioral Trials Office, Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. FAU - Marsh, Madeline AU - Marsh M AUID- ORCID: 0009-0002-4142-0119 AD - Behavioral Trials Office, Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. FAU - Hively, Adam AU - Hively A AUID- ORCID: 0009-0003-0501-2887 AD - Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. FAU - Warner, Jacqueline AU - Warner J AD - Psychiatry and Behavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. FAU - Davis, Ann AU - Davis A AD - Department of Pediatrics, University of Kansas Medical Center, Kansas City, Missouri, United States of America. AD - Center for Children's Healthy Lifestyles & Nutrition, Kansas City, Missouri, United States of America. FAU - Jackson, Jamie L AU - Jackson JL AD - Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. AD - Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, United States of America. FAU - Black, William AU - Black W AD - Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. LA - eng SI - ClinicalTrials.gov/NCT06923891 GR - K23 AR078337/AR/NIAMS NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260730 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - *Musculoskeletal Pain/psychology/therapy/physiopathology MH - Pilot Projects MH - Child MH - *Exercise/psychology MH - Female MH - Male MH - *Chronic Pain/psychology/therapy/physiopathology MH - Self Efficacy MH - *Resilience, Psychological MH - Clinical Trials, Phase II as Topic PMC - PMC13422864 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/30 18:36 MHDA- 2026/07/30 18:37 PMCR- 2026/07/30 CRDT- 2026/07/30 13:44 PHST- 2026/06/30 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/30 18:37 [medline] PHST- 2026/07/30 18:36 [pubmed] PHST- 2026/07/30 13:44 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - PONE-D-26-29534 [pii] AID - 10.1371/journal.pone.0353010 [doi] PST - epublish SO - PLoS One. 2026 Jul 30;21(7):e0353010. doi: 10.1371/journal.pone.0353010. eCollection 2026. PMID- 42531282 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Radiographic legal age estimation based on third molar development using Machine-learning algorithms. PG - e0354704 LID - 10.1371/journal.pone.0354704 [doi] LID - e0354704 AB - BACKGROUND: Age assessment plays an important role in forensic sciences to aid in criminal or civil matters. Third molars continue developing during the legal age of adulthood. Dental age estimation based on radiographic examination is an operator-dependent procedure. The aim was to test the performance of supervised machine learning (SML) to classify individuals according to the threshold of 18 years using the third molar index (I3m). METHODS: Panoramic radiographs (n = 597) of 52% males and 48% females between 13 and 26 years were used. Three Convolutional Neural Networks were compared to segment the third molar. Several machine learning algorithms were tested with a 10-fold cross-validation approach to identify the best age classification algorithm. The SML age estimation model was compared to the expert. RESULTS: Attention U-Net achieved the highest segmentation scores, and the k-nearest neighbors (KNN) showed the best scores of classification algorithms. The SML (KNN) scored sensitivity = 77.77%, specificity = 96%, and AUC = 0.87 in males. In females, sensitivity = 77.4%, specificity = 86.7%, and AUC = 0.82. The expert scores were: sensitivity = 70.4%, specificity = 100%, AUC = 0.85 for male, and for female: sensitivity = 54.8%, specificity = 93.3%, AUC = 0.74. CONCLUSION: SML classified males and females below and above the legal age with high accuracy compared to manual methods. The presented work suggests that AI, using pixel-level analysis, can detect subtle cues beyond human perception. This signals a possible departure from traditional age estimation indices. CI - Copyright: (c) 2026 Alsufyani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Alsufyani, Noura AU - Alsufyani N AUID- ORCID: 0000-0002-7627-5073 AD - Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. FAU - Alowa, Sawsan AU - Alowa S AD - Riyadh, Saudi Arabia. FAU - Alrasheed, Hend AU - Alrasheed H AD - Department of Information Technology, College of Computer and Information Sciences, King Saud University, Riyadh, Saudi Arabia. FAU - Alqahtani, Sakher AU - Alqahtani S AD - Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260730 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Molar, Third/diagnostic imaging/growth & development MH - *Age Determination by Teeth/methods MH - Male MH - Adolescent MH - *Machine Learning MH - Young Adult MH - Algorithms MH - Adult MH - Radiography, Panoramic/methods MH - Classification Algorithms MH - Convolutional Neural Networks MH - Prediction Algorithms PMC - PMC13422845 COIS- NONE. EDAT- 2026/07/30 18:36 MHDA- 2026/07/30 18:37 PMCR- 2026/07/30 CRDT- 2026/07/30 13:44 PHST- 2025/12/05 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/30 18:37 [medline] PHST- 2026/07/30 18:36 [pubmed] PHST- 2026/07/30 13:44 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - PONE-D-25-62206 [pii] AID - 10.1371/journal.pone.0354704 [doi] PST - epublish SO - PLoS One. 2026 Jul 30;21(7):e0354704. doi: 10.1371/journal.pone.0354704. eCollection 2026. PMID- 42531267 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260825 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 7 DP - 2026 TI - Prevalence, patterns and associated behavioural risk factors of multimorbidity in rural India: Cross-sectional analysis from the Andhra Pradesh Children and Parents Study (APCAPS). PG - e0006694 LID - 10.1371/journal.pgph.0006694 [doi] LID - e0006694 AB - The prevalence of multimorbidity is projected to increase substantially in India. Previous studies have focused on urban populations and older adults, who do not represent the majority of those at risk. We aimed to estimate the prevalence and investigate patterns of multimorbidity in a rural population in India and examine their associations with four common behavioural risk factors (BRFs): daily drinking, tobacco consumption, physical inactivity, and poor sleep. This cross-sectional analysis used data of all adult participants (aged >/=18 years, mean age of 35.5 years) from the third follow-up of Andhra Pradesh Children and Parents Study (APCAPS), 2010-12. We used binary logistic regression to examine the associations between BRFs, ascertained through validated questionnaires, and the prevalence of multimorbidity, defined as having two or more of 13 common chronic conditions. We used latent class analysis (LCA) to investigate common patterns of multimorbidity, followed by multinomial logistic regression to examine their associations with BRFs (categorised as binary), adjusted for age, sex, and household socioeconomic status. Of 5332 adult participants (mean age 35.5 years, standard deviation 13.8 years) included in the analysis, 14.2% had multimorbidity, the prevalence of which increased steeply with age. Current tobacco consumption (adjusted odds ratio (aOR) = 1.23 [95% confidence interval (CI): 1.01-1.50]), physical inactivity (aOR: 1.66 [95% CI: 1.38-1.99]), and poor sleep (aOR: 1.86 [95% CI: 1.35-2.57]) were associated with higher odds of having multimorbidity. We found one multimorbidity pattern of "anaemia and hypertension" (n = 220, 4.1%). Physical inactivity (aOR: 2.07 [95% CI: 1.52-2.82]) was associated with higher odds of having this multimorbidity pattern, with no associations found for the other BRFs. The BRFs identified, notably physical activity, could present important opportunities for intervention to reduce the burden of multimorbidity in India. Longitudinal studies are needed to confirm these relationships. CI - Copyright: (c) 2026 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Song, Wenbo AU - Song W AUID- ORCID: 0000-0002-1588-8597 AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. AD - School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. AD - Department of Methodology, London School of Economics & Political Science, London, United Kingdom. FAU - Lieber, Judith AU - Lieber J AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Yamanashi, Hirotomo AU - Yamanashi H AD - School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. AD - Department of General Medicine, Nagasaki University, Nagasaki, Japan. FAU - Matsuzaki, Mika AU - Matsuzaki M AD - Department of International Health, Johns Hopkins University, Baltimore, Maryland, United States of America. FAU - Lewin, Alex AU - Lewin A AUID- ORCID: 0000-0003-0081-7582 AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Gittelsohn, Joel AU - Gittelsohn J AD - Department of International Health, Johns Hopkins University, Baltimore, Maryland, United States of America. FAU - Hazell, Matthew AU - Hazell M AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Banjara, Santosh Kumar AU - Banjara SK AUID- ORCID: 0000-0002-0893-9552 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Mahajan, Hemant AU - Mahajan H AUID- ORCID: 0000-0001-7874-9191 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Bhogadi, Santhi AU - Bhogadi S AUID- ORCID: 0000-0002-7713-8804 AD - Indian Institute of Public Health, Bengaluru, India. FAU - Addanki, Srivalli AU - Addanki S AD - Indian Institute of Public Health, Bengaluru, India. FAU - Kurmi, Om AU - Kurmi O AD - Centre for Healthcare and Communities, Coventry University, Coventry, United Kingdom. FAU - Iyer, Gowri AU - Iyer G AD - Indian Institute of Public Health, Bengaluru, India. FAU - Kamalakannan, Sureshkumar AU - Kamalakannan S AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. AD - School of Communities and Education, Northumbria University, Newcastle Upon Tyne, United Kingdom. FAU - Sadanand, Shilpa AU - Sadanand S AUID- ORCID: 0000-0002-2097-2187 AD - Indian Institute of Public Health, Bengaluru, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. AD - Indian Council of Medical Research, New Delhi, India. FAU - Kinra, Sanjay AU - Kinra S AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Mallinson, Poppy A C AU - Mallinson PAC AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20260730 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC13422877 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/30 18:36 MHDA- 2026/07/30 18:37 PMCR- 2026/07/30 CRDT- 2026/07/30 13:43 PHST- 2025/08/11 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/30 18:37 [medline] PHST- 2026/07/30 18:36 [pubmed] PHST- 2026/07/30 13:43 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - PGPH-D-25-01731 [pii] AID - 10.1371/journal.pgph.0006694 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Jul 30;6(7):e0006694. doi: 10.1371/journal.pgph.0006694. eCollection 2026. PMID- 42530761 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20261008 IS - 1613-9674 (Electronic) IS - 0911-6028 (Linking) VI - 42 IP - 4 DP - 2026 Oct TI - Application of a novel age estimation model based on permanent maxillary canine morphometric features in a Japanese population. PG - 1121-1131 LID - 10.1007/s11282-026-00952-4 [doi] AB - OBJECTIVES: This study aims to clarify the growth curves of the long axis and apical foramen diameter of permanent maxillary canines (PMCs), and to create and evaluate a new nonlinear age estimation (NAGE) model by integrating their inverse functions within a machine learning framework. METHODS: CT measurements of length (L), apical shortest width (SW) and longest width (LW) were obtained from 726 PMCs (aged 1 to 23 years). Growth curves were modeled using Gompertz function for L and Gamma-type function for SW and LW. Inverse functions were integrated into the NAGE model: [Formula: see text]. Parameters were optimized using Soft-L1 robust least squares (SciPy, NumFOCUS, USA). Validation applied to 14 independent longitudinal cases (75 PMCs, 3-15 years). Agreement between predicted age (PA) and chronological age (CA) was evaluated using root mean squared error (RMSE), coefficient of determination (R(2)), and Wilcoxon signed-rank test. RESULTS: The Gompertz and Gamma-type functions effectively captured PMC growth, with RMSE of 2.5 mm (L), 1.07 mm (SW), and 1.45 mm (LW). The NAGE achieved RMSE of 1.89 years (R(2) = 0.85) in the 1-23 years group, improving to 1.29 years (R(2) = 0.89) in the 1-16 years group. In longitudinal cases, the overall mean difference between PA and CA was 0.12 years (1.4 months) with an RMSE of 0.99 years (R(2) = 0.86) and individual errors ranging from 0.25 to 2.09 years. CONCLUSIONS: The proposed NAGE model showed promising performance for dental age estimation based on PMC length and apical foramen widths. Further studies in other teeth are needed. CI - (c) 2026. The Author(s) under exclusive licence to Japanese Society for Oral and Maxillofacial Radiology. FAU - Prakoeswa, Beshlina Fitri Widayanti Roosyanto AU - Prakoeswa BFWR AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. AD - Department of Forensic Odontology, Faculty of Dental Medicine Universitas Airlangga, Surabaya, 60132, Indonesia. FAU - Nishiyama, Hideyoshi AU - Nishiyama H AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. nisiyama@dent.niigata-u.ac.jp. FAU - Kobayashi, Taichi AU - Kobayashi T AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Ike, Makiko AU - Ike M AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Takamura, Masaki AU - Takamura M AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Nikkuni, Yutaka AU - Nikkuni Y AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Katsura, Kouji AU - Katsura K AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Vo, Diem T AU - Vo DT AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Hayashi, Takafumi AU - Hayashi T AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. LA - eng PT - Journal Article DEP - 20260730 PL - Japan TA - Oral Radiol JT - Oral radiology JID - 8806621 RN - Japanese people SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Young Adult MH - *Age Determination by Teeth/methods MH - *Cuspid/growth & development/diagnostic imaging/anatomy & histology MH - Japan/ethnology MH - Machine Learning MH - Maxilla MH - Tomography, X-Ray Computed/methods MH - East Asian People OTO - NOTNLM OT - Age determination by teeth OT - Computed tomography OT - Machine learning OT - Maxillary canine OT - Morphometry COIS- Declarations. Conflict of interest: All authors declare no conflicts of interest. Ethical approval: This study was conducted in the Division of Oral and Maxillofacial Radiology of Niigata University, Japan and approved by the ethical review committee (approval No: 2023 - 0330). EDAT- 2026/07/30 12:43 MHDA- 2026/09/29 05:30 CRDT- 2026/07/30 11:19 PHST- 2026/05/11 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/09/29 05:30 [medline] PHST- 2026/07/30 12:43 [pubmed] PHST- 2026/07/30 11:19 [entrez] AID - 10.1007/s11282-026-00952-4 [pii] AID - 10.1007/s11282-026-00952-4 [doi] PST - ppublish SO - Oral Radiol. 2026 Oct;42(4):1121-1131. doi: 10.1007/s11282-026-00952-4. Epub 2026 Jul 30. PMID- 42530682 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 30 TI - Pediatric eosinophilic esophagitis: diagnostic and therapeutic insights from a 15-year retrospective study. LID - 10.1007/s00431-026-07270-1 [doi] LID - 626 AB - Eosinophilic Esophagitis (EoE) is a chronic inflammatory disorder with variable macroscopic and microscopic findings and clinical presentations, complicating management. This study examines esophageal sampling practices, segmental disease patterns, and longitudinal treatment trends and outcomes in pediatric EoE. We retrospectively reviewed charts of 138 pediatric EoE patients diagnosed between 2009 and 2023. EoE was defined as compatible symptoms and >/= 15 eosinophils per high-power-field without alternative explanation. Diagnostic endoscopy was defined as the first endoscopy performed for evaluation of symptoms showing >/= 15 eosinophils. Data included demographics, symptoms, macroscopic/microscopic findings, sampling methods, and treatments. Mean age at diagnosis was 8.33 +/- 5.37 years, 75% male. Most common presenting symptoms were vomiting (39.28%), dysphagia (32.14%) and food impaction (28.57%). Among 112 diagnostic endoscopies, macroscopic abnormalities were most frequent in the lower esophagus (85.71%), with furrows (69.64%) and exudates (55.36%) predominating. Multi-level sampling in patients with >/= 15 eosinophils in one field, revealed < 15 eosinophils in 21.11% of upper, 7.14% of middle, and 14.14% of lower esophageal samples. Microscopic findings despite normal endoscopic appearance were most common in the upper (26.4%, p < 0.001), and less frequently in the lower (9.8% p = 0.002) esophagus. Remission following first-line therapy was achieved in 44 patients (48.35%). Biologic therapy was initiated after multiple prior treatment failures and resulted in histologic remission in all treated patients (n = 9). CONCLUSIONS: Findings indicate greater disease severity distally and underscore the need for multi-regional sampling, even in normal-appearing areas. Therapeutic responses are heterogenous and limited, and biologic therapies show promise but require validation in larger studies. WHAT IS KNOWN: * Pediatric eosinophilic esophagitis (EoE) is a chronic immune-mediated disease with variable endoscopic findings, requiring both compatible clinical features and histologic evidence of >/=15 eosinophils per high-power field. * Empiric elimination diets and proton pump inhibitors are considered first-line treatments, with variable remission rates. WHAT IS NEW: * Pan-esophageal multi-level biopsies, including from normal-appearing mucosa, improve diagnostic accuracy. * While first-line therapies show mild success rates, real-world data demonstrate complete histologic remission with biologic therapy, supporting its promise for pediatric EoE. CI - (c) 2026. The Author(s). FAU - Greenberger, Sraya AU - Greenberger S AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - "Tzameret" Program, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Davidovics, Zev AU - Davidovics Z AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Milman, Peri AU - Milman P AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Orgad, Tamar AU - Orgad T AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. FAU - Haimov, Elinor AU - Haimov E AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. FAU - Reif, Shimon AU - Reif S AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Pappo, Orit AU - Pappo O AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. AD - Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. FAU - Elia, Anna AU - Elia A AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. AD - Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. FAU - Wilschanski, Michael AU - Wilschanski M AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Slae, Mordechai AU - Slae M AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Birimberg-Schwartz, Liron AU - Birimberg-Schwartz L AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. lbschwartz@hadassah.org.il. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. lbschwartz@hadassah.org.il. LA - eng PT - Journal Article DEP - 20260730 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Proton Pump Inhibitors) SB - IM MH - Humans MH - *Eosinophilic Esophagitis/diagnosis/therapy/pathology MH - Retrospective Studies MH - Male MH - Female MH - Child MH - Esophagoscopy MH - Child, Preschool MH - Esophagus/pathology MH - Adolescent MH - Eosinophils MH - Proton Pump Inhibitors/therapeutic use PMC - PMC13424580 OTO - NOTNLM OT - Endoscopy OT - Eosinophilic Esophagitis OT - Histology OT - Management COIS- Declarations. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Hadassah University Medical Center (Date: 26/10/2023 No: HMO-0326-23). Informed consent was waived due to the study's retrospective observational nature. Competing interests: The authors declare no competing interests. EDAT- 2026/07/30 12:43 MHDA- 2026/07/30 12:44 PMCR- 2026/07/30 CRDT- 2026/07/30 11:16 PHST- 2026/04/30 00:00 [received] PHST- 2026/07/18 00:00 [accepted] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/30 12:44 [medline] PHST- 2026/07/30 12:43 [pubmed] PHST- 2026/07/30 11:16 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - 10.1007/s00431-026-07270-1 [pii] AID - 7270 [pii] AID - 10.1007/s00431-026-07270-1 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 30;185(8):626. doi: 10.1007/s00431-026-07270-1. PMID- 42529941 OWN - NLM STAT- Publisher LR - 20260730 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Jul 30 TI - Functional roles and nutritional potential of human milk oligosaccharides in swine gut health. PG - 1-44 LID - 10.1017/S0007114526107776 [doi] AB - Human milk oligosaccharides (HMOs) are a prominent class of bioactive glycans recognized for their pivotal roles as prebiotics, anti-adhesive antimicrobials, and immunomodulators in neonatal development. While traditionally studied in the context of infant nutrition, scalable biotechnological production now allows for their evaluation in swine production to address the relatively lower structural complexity of the porcine milk glycome compared to humans. This review critically evaluates the structural diversity and biosynthesis of HMOs, detailing how specific fucosylated and sialylated structures modulate the porcine gut microbiome and reinforce intestinal barrier integrity. We synthesize current evidence regarding the metabolic fate of these glycans in the piglet and address the translational relevance of using swine as high-fidelity models for human gastrointestinal physiology. Furthermore, the review identifies critical knowledge gaps, specifically the lack of large-scale longitudinal studies and comprehensive cost-benefit analyses required to validate the economic feasibility of HMOs in commercial agriculture. By consolidating these mechanistic insights within the context of global efforts to reduce reliance on antibiotic growth promoters, this work underscores the potential of HMOs as precision nutritional tools to enhance resilience and productivity in sustainable animal production systems. FAU - El Bouhi, Romaissaa AU - El Bouhi R AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Hu, Qinfeng AU - Hu Q AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Zhong, Jie AU - Zhong J AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Zhou, Pan AU - Zhou P AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Zhang, Yong AU - Zhang Y AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Liu, Lingbin AU - Liu L AD - College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Beibei, 400700, Chongqing, China. FAU - Yan, Honglin AU - Yan H AUID- ORCID: 0000-0002-2597-6902 AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. LA - eng PT - Journal Article PT - Review DEP - 20260730 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - gut microbiota OT - human milk oligosaccharides OT - immune modulation OT - intestinal health OT - piglet health OT - prebiotics OT - swine nutrition EDAT- 2026/07/30 12:43 MHDA- 2026/07/30 12:43 CRDT- 2026/07/30 06:23 PHST- 2026/07/30 12:43 [medline] PHST- 2026/07/30 12:43 [pubmed] PHST- 2026/07/30 06:23 [entrez] AID - S0007114526107776 [pii] AID - 10.1017/S0007114526107776 [doi] PST - aheadofprint SO - Br J Nutr. 2026 Jul 30:1-44. doi: 10.1017/S0007114526107776. PMID- 42529401 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260824 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Beyond the game: evaluating a soccer-centered approach to physical activity and health education in children. PG - 1765167 LID - 10.3389/fspor.2026.1765167 [doi] LID - 1765167 AB - BACKGROUND/OBJECTIVES: Due to only 25% of U.S. children meeting the physical activity guidelines, we aimed to determine feasibility of team sports to engage children in at least 60 min of moderate-to-vigorous physical activity daily and increase health knowledge. METHODS: This 11-week quasi-experimental pre/post intervention study was conducted in two after-school programs around metro Atlanta, GA, USA (C1, n = 18; C2, n = 22). The 11 for Health program is an 11-week active learning model that involves 2 x 45 min per week soccer drills, small-sided games, and health education modules. Assessments included health knowledge and physical fitness metrics such as estimated VO(2), standing long jump, balance, agility, and handgrip strength. Non-participants were defined as missing 3 or more sessions and/or not participating in the activities. Descriptive statistics and t-tests were used to compare pre- and post-intervention assessments, stratified by participation level. RESULTS: C1 were on average 9.2 years old, 31% female, and 100% White. C2 were on average 9.8 years, 48% female, and 67% Hispanic and 33% Black. Attendance was 69% (SD 0.26) in average over the 11 weeks for both cohorts, with no difference in attendance between groups. Agility improved significantly [2.7 s(1.5); 95% CI: -3.2,-2.2] overall but no between-group difference was found. C2 participants improved significantly compared to C1 participants (p = 0.006) in left handgrip. C1 performed significantly better on the health knowledge test (p = 0.023; 95% CI: 0.018, 0.225) but neither cohort improved over time. CONCLUSION: The program is feasible for American children; however, careful consideration of setting and coaching staff is necessary. CI - (c) 2026 Foster, Li, Juarez, Pelkmans, Fluellen, Li, Lee, Munoz, Rohith, Krustrup, Larsen and Frediani. FAU - Foster, Jordan D AU - Foster JD AD - Rollins School of Public Health, Emory University, Atlanta, GA, United States. FAU - Li, Eva AU - Li E AD - Emory College of Arts and Humanities, Emory University, Atlanta, GA, United States. FAU - Juarez, Arturo Jr AU - Juarez A Jr AD - Emory College of Arts and Humanities, Emory University, Atlanta, GA, United States. FAU - Pelkmans, Jordan AU - Pelkmans J AD - Nell Woodruff Hodgson School of Nursing, Emory University, Atlanta, GA, United States. FAU - Fluellen, Staci AU - Fluellen S AD - School of Public Health, Georgia State University, Atlanta, GA, United States. FAU - Li, Kevin AU - Li K AD - Emory College of Arts and Humanities, Emory University, Atlanta, GA, United States. FAU - Lee, Jocelyn AU - Lee J AD - Emory College of Arts and Humanities, Emory University, Atlanta, GA, United States. FAU - Munoz, Leilany AU - Munoz L AD - Nell Woodruff Hodgson School of Nursing, Emory University, Atlanta, GA, United States. FAU - Rohith, Siddhanth AU - Rohith S AD - Alliance Academy for Innovation, Cumming, GA, United States. FAU - Krustrup, Peter AU - Krustrup P AD - Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - Sport and Health Sciences, University of Exeter, Exeter, United Kingdom. FAU - Larsen, Malte N AU - Larsen MN AD - Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Frediani, Jennifer K AU - Frediani JK AD - Nell Woodruff Hodgson School of Nursing, Emory University, Atlanta, GA, United States. LA - eng GR - P30 DK111024/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260715 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13417902 OTO - NOTNLM OT - association football OT - children OT - health knowledge OT - health literacy OT - physical fitness OT - soccer COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/30 06:41 MHDA- 2026/07/30 06:42 PMCR- 2026/07/15 CRDT- 2026/07/30 05:03 PHST- 2025/12/10 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/07/30 06:42 [medline] PHST- 2026/07/30 06:41 [pubmed] PHST- 2026/07/30 05:03 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.3389/fspor.2026.1765167 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jul 15;8:1765167. doi: 10.3389/fspor.2026.1765167. eCollection 2026. PMID- 42528895 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Predicting serum phosphate levels in very preterm infants using machine learning. PG - 1881474 LID - 10.3389/fped.2026.1881474 [doi] LID - 1881474 AB - BACKGROUND: Hypophosphatemia in very preterm and small for gestational age (SGA) infants is common and associated with serious complications. Diagnosis relies on phosphate concentrations, measured in serum or plasma. Machine learning (ML) may enable indirect estimation of serum phosphate based on routinely collected clinical data and results from blood gas analysis. OBJECTIVES: To (1) describe first week electrolyte trajectories in the ImNuT-trial (Clinicaltrials.gov ID: NCT03555019), and (2) develop and externally validate ML models to estimate serum phosphate levels during the first postnatal week in very preterm infants, using routinely collected clinical and nutritional data. METHODS: We performed a retrospective analysis of 120 infants born <29 weeks' gestation, all managed under a standardized nutritional protocol. Electrolyte trajectories (calcium, potassium, sodium, phosphate) were described using daily means stratified by hypophosphatemia and SGA status. For ML, we defined three regression tasks: concurrent phosphate prediction at blood gas analysis, and forecasts 12 h and 24 h ahead. Twenty-two candidate predictors from blood gases, anthropometry, SGA status and nutrient intakes were subjected to RENT-based variable selection within leave-one-group-out cross-validation. Multiple algorithms (elastic net, gradient boosting, random forests, k-nearest neighbours, kernel ridge, XGBoost) were trained under three preprocessing strategies (complete cases, complete cases without outliers, imputed data). Performance was evaluated with RMSE and R (2) using nested cross-validation and an independent external cohort of 40 very preterm infants. RESULTS: Among 119 infants with phosphate measurements (607 samples), 33.6% developed hypophosphatemia in week one. SGA infants had a markedly higher and earlier risk of hypophosphatemia compared to appropriate-for-gestational-age infants (log-rank p < 0.0001). Six predictors (calcium, potassium, gestational age, SGA status, birth weight z-score, daily weight z-score) were consistently retained across all prediction tasks. Elastic net models performed best externally on all three prediction tasks. Performance was robust across preprocessing strategies. CONCLUSIONS: SGA status is a major determinant of early hypophosphatemia risk in very preterm infants. ML models using routinely available clinical and nutritional data can moderately but consistently estimate serum phosphate levels, including 12-24 h ahead, and may serve as screening tools to guide nutritional management and reduce unnecessary blood sampling. Prospective validation is warranted before clinical implementation. CI - (c) 2026 Westvik, Tomic, Tscherning and Moltu. FAU - Westvik, Asbjorn S AU - Westvik AS AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. AD - Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway. FAU - Tomic, Oliver AU - Tomic O AD - Faculty of Science and Technology, Norwegian University of Life Sciences, As, Norway. FAU - Tscherning, Charlotte AU - Tscherning C AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. AD - Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway. FAU - Moltu, Sissel J AU - Moltu SJ AD - Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway. LA - eng SI - ClinicalTrials.gov/NCT03555019 PT - Journal Article DEP - 20260715 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13415508 OTO - NOTNLM OT - hypophosphatemia OT - machine learning OT - prediction model OT - preterm infant OT - refeeding syndrome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/30 06:41 MHDA- 2026/07/30 06:42 PMCR- 2026/07/15 CRDT- 2026/07/30 04:48 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/30 06:42 [medline] PHST- 2026/07/30 06:41 [pubmed] PHST- 2026/07/30 04:48 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.3389/fped.2026.1881474 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 15;14:1881474. doi: 10.3389/fped.2026.1881474. eCollection 2026. PMID- 42528788 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Prepregnancy body mass index and risk of macrosomia after fresh embryo transfer: a retrospective cohort study with exploratory threshold analysis. PG - 1884067 LID - 10.3389/fendo.2026.1884067 [doi] LID - 1884067 AB - BACKGROUND: Higher prepregnancy body mass index (BMI) is a well-established risk factor for adverse neonatal outcomes in IVF-conceived pregnancies; therefore, weight management is important for infertile patients, yet it remains challenging. Determining a clinically applicable BMI threshold for neonatal outcome risk assessment in fresh embryo transfer (fresh ET) cycles is meaningful; however, it remains undetermined. Therefore, this study aimed to identify an exploratory BMI threshold associated with increased risk of adverse neonatal outcomes after fresh ET, providing a preliminary reference for clinical risk communication. METHODS: This retrospective cohort study included 2,195 women who underwent autologous fresh ET between June 2019 and December 2023. Multivariable regression analysis examined the association between prepregnancy BMI and neonatal outcomes. Smooth curve fitting and threshold effect analysis identified the exploratory BMI threshold. Adjusted analysis following propensity score matching (PSM) was conducted as a sensitivity analysis to validate the robustness of the results. RESULTS: The multivariate regression analyses revealed that birthweight (adjusted beta: 22.63, 95% CI: 14.53 to 30.73; P<0.001) and Z-score (adjusted beta: 0.06, 95% CI: 0.04 to 0.08; P<0.001) were positively associated with increasing maternal BMI. Compared with the reference group (BMI 18.5-24.9 kg/m(2)), the incidence of macrosomia was increased by 2.25-fold in the BMI 25-29.9 kg/m(2) group (adjusted OR: 2.25, 95% CI: 1.29 to 3.93; P = 0.004) and by 4.56-fold in the BMI >/=30 kg/m(2) group (adjusted OR: 4.56, 95% CI: 2.26 to 9.22; P<0.001). Smooth curve fitting and threshold effect analysis revealed a significant increase in the odds of macrosomia when BMI exceeded 26.22 kg/m(2) (adjusted OR: 4.05, 95% CI: 2.47 to 7.29; P = 0.0009). PSM analysis confirmed that patients with a BMI >26.22 kg/m(2) (adjusted OR: 3.01, 95% CI: 2.02 to 4.47; P<0.001) had significantly higher odds of macrosomia compared to those with BMI .90, CV < 5%) repeatability, although the ASH test demonstrated good-to-excellent relative repeatability (ICC = .87-.90) but greater absolute variability (CV > 10%). CONCLUSION: CMJ and ballistic push-up testing on a force plate are suitable for athlete monitoring in competitive swimming. The ASH test demonstrated greater variability between sessions, highlighting the need for further evaluation prior to its integration into athlete monitoring assessments. FAU - McKenzie, Mark AU - McKenzie M AUID- ORCID: 0009-0005-7326-3535 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. FAU - Boon-van Mossel, Nathan AU - Boon-van Mossel N AUID- ORCID: 0009-0007-2948-0131 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. FAU - McClean, Zachary J AU - McClean ZJ AUID- ORCID: 0000-0002-7219-9448 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. FAU - Jordan, Matthew J AU - Jordan MJ AUID- ORCID: 0000-0002-8044-1441 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Sport Medicine Centre, University of Calgary, Calgary, AB, Canada. LA - eng PT - Journal Article DEP - 20260729 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - Humans MH - *Swimming/physiology/injuries MH - Female MH - Reproducibility of Results MH - *Muscle Strength/physiology MH - *Exercise Test/methods MH - Male MH - Young Adult MH - Canada MH - Return to Sport MH - *Shoulder/physiology MH - Universities MH - Adolescent OTO - NOTNLM OT - athletic shoulder test OT - countermovement jump OT - push-up OT - shoulder girdle OT - strength assessment EDAT- 2026/07/30 00:38 MHDA- 2026/09/29 19:03 CRDT- 2026/07/29 19:32 PHST- 2025/11/03 00:00 [received] PHST- 2026/04/01 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/09/29 19:03 [medline] PHST- 2026/07/30 00:38 [pubmed] PHST- 2026/07/29 19:32 [entrez] AID - 10.1123/ijspp.2025-0499 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2026 Jul 29;21(10):1198-1202. doi: 10.1123/ijspp.2025-0499. Print 2026 Oct 1. PMID- 42526856 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 23 IP - 11 DP - 2026 Nov 1 TI - Parent-Reported 24-Hour Movement Behaviors and Executive Functions for Preschool Children: Evidence From Iraq. PG - 1697-1704 LID - 10.1123/jpah.2026-0141 [doi] AB - BACKGROUND: Growing evidence highlights the importance of 24-hour movement behaviors for children's executive functions. However, evidence from Arab countries, particularly Iraq, remains limited. METHODS: A cross-sectional sample of 210 preschool children (4-6 y old) was randomly selected from 14 kindergartens in Samarra, Iraq during the 2025-2026 academic year. Daily time spent in light, moderate, and vigorous physical activity; sedentary behavior; recreational screen time; and sleep duration was reported by parents using an Arabic 24-hour time log with acceptable internal consistency (Cronbach alpha = .77). Executive functions were measured using the Head-Toes-Knees-Shoulders Revised task. Pearson correlations were used as descriptive indicators, and multiple regression and compositional data analysis using isometric log-ratio balances were applied for inferential interpretation. RESULTS: Head-Toes-Knees-Shoulders Revised scores were positively associated with moderate to vigorous physical activity and sleep duration and negatively associated with sedentary behavior and recreational screen time (all P < .001). Compositional data analysis showed that isometric log-ratio balances representing moderate to vigorous physical activity relative to remaining behaviors, as well as sleep relative to waking behaviors, were significantly associated with higher Head-Toes-Knees-Shoulders Revised scores (P < .001). In contrast, the balance between screen time and nonscreen sedentary behavior was not statistically significant. CONCLUSIONS: A balanced daily routine, characterized by active movement, sufficient sleep, and limited screen time, was associated with better executive function performance in early childhood. FAU - Ibrahim, Abdelrahman AU - Ibrahim A AUID- ORCID: 0000-0003-1600-4404 AD - College of Physical Education and Sport Sciences, University of Samarra, Samarra, Iraq. FAU - Hawar, Ali Burhan AU - Hawar AB AUID- ORCID: 0009-0003-5148-6290 AD - College of Physical Education and Sport Sciences, University of Kirkuk, Kirkuk, Iraq. FAU - Jebur, Mohammed Saad AU - Jebur MS AUID- ORCID: 0009-0003-0927-0912 AD - College of Physical Education and Sport Sciences, University of Tikrit, Tikrit, Iraq. FAU - Ahmed, Mayada H AU - Ahmed MH AUID- ORCID: 0009-0008-9178-4870 AD - College of Physical Education and Sport Sciences, University of Samarra, Samarra, Iraq. FAU - Alsamarae, Mohammed Saleh Khaleel AU - Alsamarae MSK AUID- ORCID: 0000-0002-1353-973X AD - College of Physical Education and Sport Sciences, University of Samarra, Samarra, Iraq. LA - eng PT - Journal Article DEP - 20260728 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - *Executive Function/physiology MH - Child, Preschool MH - Female MH - Cross-Sectional Studies MH - Male MH - Sedentary Behavior MH - Sleep Duration MH - *Exercise/physiology MH - Iraq MH - Parents MH - Screen Time MH - Child MH - Sleep OTO - NOTNLM OT - moderate to vigorous physical activity OT - recreational screen exposure OT - sedentary behavior OT - self-regulation OT - sleep health EDAT- 2026/07/30 00:38 MHDA- 2026/10/27 17:29 CRDT- 2026/07/29 19:32 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/10/27 17:29 [medline] PHST- 2026/07/30 00:38 [pubmed] PHST- 2026/07/29 19:32 [entrez] AID - 10.1123/jpah.2026-0141 [doi] PST - epublish SO - J Phys Act Health. 2026 Jul 28;23(11):1697-1704. doi: 10.1123/jpah.2026-0141. Print 2026 Nov 1. PMID- 42525831 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1469-0756 (Electronic) IS - 0032-5473 (Linking) VI - 102 IP - 1213 DP - 2026 Oct 22 TI - Modifiable behavioral factors associated with myopia among school-aged children. PG - 1037-1043 LID - 10.1093/postmj/qgag101 [doi] AB - BACKGROUND: This study aimed to examine behavioral factors associated with myopia among school-aged children. METHODS: School physical examination records and parent-administered questionnaire data were collected from nine schools in Haizhu District, Guangzhou. Least absolute shrinkage and selection operator (LASSO) regression was used to reduce multicollinearity and select candidate predictors, followed by univariate and multivariate logistic regression analyses. Non-behavioral factors were included as adjustment covariates. RESULTS: A total of 4957 students were included in the analysis, with a mean age of 10.7 +/- 2.42 years; 2661 students were boys and 2296 were girls. After adjustment for demographic, familial, anthropometric, and parental educational covariates, homework time 2-4 h per day was associated with higher odds of myopia [odds ratio (OR) = 1.24; 95% confidence interval (CI) = 1.07-1.44, P = .004]. In contrast, an eye-to-screen distances >/=30 cm (OR = 0.77; 95% CI = 0.65-0.92, P = .004), an eye-to-book distance >/=30 cm (OR = 0.82; 95% CI = 0.71-0.95, P = .008), and daily outdoor activity >30 min (OR = 0.87; 95% CI: 0.77-0.98; P = .026) were associated with lower odds of myopia. CONCLUSIONS: Several modifiable behavioral factors were associated with myopia among school-aged children. Maintaining an appropriate near-work distance, limiting prolonged after-school homework or reading time, and increasing outdoor activity may provide practical targets for school- and family-based myopia prevention. Key messages What is already known on this topic: Previous studies have shown that prolonged near work and limited outdoor time are associated with myopia in children. However, evidence remains inconsistent regarding specific daily visual behaviors, such as eye-to-screen distance, eye-to-book distance, and homework duration. What this study adds: This study adds evidence that several feasible daily behaviors, including maintaining a near-work distance of >30 cm, limiting prolonged homework time, and spending >30 min outdoors per day, were associated with lower odds of myopia in school-aged children. How this study might affect research, practice, or policy: In practice, these findings suggest that schools and families may consider promoting appropriate near-work distance, regular breaks during homework or reading, and more opportunities for outdoor activity during the school day. Further evidence from longitudinal and interventional studies is needed before these thresholds are incorporated into formal guidelines or policy recommendations. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Fellowship of Postgraduate Medicine. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Lin, Min AU - Lin M AD - Department of Ophthalmology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, No. 466 Xingang Middle Road, Haizhu District, Guangzhou 510317, Guangdong, China. FAU - Tang, Xiaodi AU - Tang X AD - Department of Ophthalmology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, No. 466 Xingang Middle Road, Haizhu District, Guangzhou 510317, Guangdong, China. FAU - Lei, Peng AU - Lei P AD - Dongguan Children's Hospital Affiliated to Guangdong Medical University, No. 86 South Xihu Third Road, Shilong Town, Dongguan 523000, Guangdong, China. FAU - Lei, Yahui AU - Lei Y AUID- ORCID: 0000-0002-7036-1632 AD - Dongguan Children's Hospital Affiliated to Guangdong Medical University, No. 86 South Xihu Third Road, Shilong Town, Dongguan 523000, Guangdong, China. LA - eng GR - 2024A03J0992/Municipal School/Institute/Enterprise Joint Funding Program of Guangzhou/ PT - Journal Article PL - England TA - Postgrad Med J JT - Postgraduate medical journal JID - 0234135 SB - IM MH - Humans MH - *Myopia/epidemiology/prevention & control MH - Female MH - Child MH - Male MH - Risk Factors MH - China/epidemiology MH - Surveys and Questionnaires MH - Schools MH - *Students/statistics & numerical data/psychology MH - Screen Time OTO - NOTNLM OT - adolescents OT - children OT - myopia OT - risk factors OT - students EDAT- 2026/07/29 18:39 MHDA- 2026/10/23 18:31 CRDT- 2026/07/29 14:52 PHST- 2026/04/12 00:00 [received] PHST- 2026/06/17 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/10/23 18:31 [medline] PHST- 2026/07/29 18:39 [pubmed] PHST- 2026/07/29 14:52 [entrez] AID - 8747062 [pii] AID - 10.1093/postmj/qgag101 [doi] PST - ppublish SO - Postgrad Med J. 2026 Oct 22;102(1213):1037-1043. doi: 10.1093/postmj/qgag101. PMID- 42525668 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Healthcare providers' perspectives and needs related to the management of Pediatric Feeding Disorder: A focus group study. PG - e0354724 LID - 10.1371/journal.pone.0354724 [doi] LID - e0354724 AB - Pediatric feeding disorder is a prevalent, impactful diagnosis for children and their families. This diagnosis is heterogenous in presentation and requires the care of a multidisciplinary team of providers. Existing research suggests providers are underprepared to assess and treat pediatric feeding disorder, therefore more information on training and clinical practice is needed. This study conducted focus groups to describe the training journey of providers across all four pediatric feeding disorder domains (medical, nutrition, feeding skill, psychosocial). Seven focus groups (total of 25 providers) were conducted and analyzed using thematic analysis. Four themes were identified: differences in academic preparation, workplace infrastructure and access, desire for comprehensiveness and feasibility, and value of the family perspective. Overall, results point to opportunities to improve provider training and therefore patient care including academic exposure to pediatric feeding disorder and multi-disciplinary collaboration practices, increased access to mentorship, training, and evidenced-based resources, and enrichment of the research to practice pipeline with a focus on family-centered care. CI - Copyright: (c) 2026 Thompson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Thompson, Kelsey AU - Thompson K AUID- ORCID: 0000-0002-3309-9516 AD - Division of Speech and Hearing Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Romeo, Cuyler AU - Romeo C AD - Feeding Matters, Phoenix, Arizona, United States of America. AD - Banner University Medical Center - Tucson, Tucson, Arizona, United States of America. FAU - Simione, Meg AU - Simione M AD - Department of Communicative Disorders, University of Rhode Island, Kingston, Rhode Island, United States of America. FAU - Estrem, Hayley AU - Estrem H AUID- ORCID: 0000-0003-2599-8893 AD - School of Nursing, University of North Carolina at Wilmington, Wilmington, North Carolina, United States of America. FAU - Pederson, Jaclyn L AU - Pederson JL AD - Feeding Matters, Phoenix, Arizona, United States of America. FAU - Sharp, William G AU - Sharp WG AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America. AD - Multidisciplinary Feeding Program, Children's Healthcare of Atlanta, Atlanta, Georgia, United States of America. LA - eng PT - Journal Article DEP - 20260729 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Focus Groups MH - *Health Personnel/psychology/education MH - *Feeding and Eating Disorders of Childhood/therapy MH - Child MH - Female MH - *Attitude of Health Personnel PMC - PMC13419198 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/29 18:39 MHDA- 2026/07/30 00:38 PMCR- 2026/07/29 CRDT- 2026/07/29 13:43 PHST- 2026/03/02 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/07/29 18:39 [pubmed] PHST- 2026/07/29 13:43 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - PONE-D-26-08691 [pii] AID - 10.1371/journal.pone.0354724 [doi] PST - epublish SO - PLoS One. 2026 Jul 29;21(7):e0354724. doi: 10.1371/journal.pone.0354724. eCollection 2026. PMID- 42525667 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Neck circumference as an anthropometric marker of overweight among school-aged children in Bharatpur, Nepal: A community-based study. PG - e0354997 LID - 10.1371/journal.pone.0354997 [doi] LID - e0354997 AB - BACKGROUND: Childhood overweight have become a major public health concern among children in developing countries. BMI, commonly used to diagnose overweight, requires standardized equipment and trained personnel, limiting their feasibility in large-scale screenings. Neck circumference (NC) has emerged as a simple and practical alternative for identifying overweight in children. This study aimed to examine the association between NC and established anthropometric indicators and to determine optimal NC cutoff values for identifying overweight among school-aged children. METHODS: A community-based descriptive cross-sectional study was conducted from July to October 2025 among 300 apparently healthy children aged 6-11 years in Ward No. 16, Bharatpur Metropolitan City, Nepal. Sociodemographic data were collected using structured interviews. Anthropometric measurements including height, weight, NC, waist circumference (WC), and hip circumference (HC) were obtained using standardized procedures. BMI-for-age classifications were based on WHO AnthroPlus growth references. Chi square test, pearson correlation, logistic regression, and receiver operating characteristic (ROC) curve analyses were performed using SPSS version 16. Statistical significance was set at p < 0.05. RESULTS: Among the 300 children, 48.3% had normal BMI-for-age, 10.3% were overweight and 41.3% were underweight. Chi square test revealed a statistically significant association between neck circumference and BMI-for-age (p < 0.001). Pearson correlation analysis demonstrated strong positive correlations between NC and weight (r = 0.792), height (r = 0.639), BMI (r = 0.723), waist circumference (r = 0.797), and hip circumference (r = 0.734) (p < 0.001 for all). ROC curve analysis indicated excellent diagnostic accuracy of NC for identifying overweight. The optimal cutoff values were 27.75 cm for boys (AUC = 0.884; sensitivity = 88.9%; specificity = 66.2%) and 26.75 cm for girls (AUC = 0.904; sensitivity = 100%; specificity = 69.4%). The overall cutoff value was 27.25 cm (AUC = 0.883; sensitivity = 80.6%; specificity = 74.3%). Multivariable logistic regression analysis confirmed NC had a statistically significant positive association with overweight with COR 12.077 (4.75-30.67) and AOR 20.817 (6.34-68.29). CONCLUSIONS: Neck circumference is significantly correlated with established anthropometric indicators and demonstrates diagnostic accuracy for identifying overweight among school-aged children. NC measurement is a simple, reliable, and cost-effective screening tool that may be particularly useful in school-based and resource-limited settings. CI - Copyright: (c) 2026 Bajracharya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Bajracharya, Subina AU - Bajracharya S AUID- ORCID: 0000-0002-5654-2111 AD - Department of Pediatric Nursing, School of Nursing, Chitwan Medical College, Bharatpur, Nepal. FAU - Neupane, Sadikshya AU - Neupane S AD - Department of Community Health Nursing, School of Nursing, Chitwan Medical College, Bharatpur, Nepal. FAU - Shrestha, Parita AU - Shrestha P AD - Department of Pediatric Nursing, School of Nursing, Chitwan Medical College, Bharatpur, Nepal. LA - eng PT - Journal Article DEP - 20260729 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Nepal/epidemiology MH - Child MH - Male MH - Female MH - *Neck/anatomy & histology MH - Cross-Sectional Studies MH - *Overweight/epidemiology/diagnosis MH - *Anthropometry/methods MH - Body Mass Index MH - ROC Curve MH - Waist Circumference PMC - PMC13419187 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/29 18:39 MHDA- 2026/07/30 00:38 PMCR- 2026/07/29 CRDT- 2026/07/29 13:43 PHST- 2026/04/06 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/07/29 18:39 [pubmed] PHST- 2026/07/29 13:43 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - PONE-D-26-16450 [pii] AID - 10.1371/journal.pone.0354997 [doi] PST - epublish SO - PLoS One. 2026 Jul 29;21(7):e0354997. doi: 10.1371/journal.pone.0354997. eCollection 2026. PMID- 42525244 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261016 IS - 1437-1596 (Electronic) IS - 0937-9827 (Print) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Hybrid approach with convolutional neural network and regression models for age estimation in panoramic radiographs. PG - 3919-3929 LID - 10.1007/s00414-026-03927-6 [doi] AB - BACKGROUND: Determining chronological age is a relevant aspect of criminal and civil interest for identifying corpses and refugees. This study aimed to estimate chronological age using a hybrid model that combines a convolutional neural network (CNN) with regression models based on panoramic radiographs. METHODS: This observational, retrospective and cross-sectional study analyzed 2,546 panoramic radiographs from a Brazilian practice. Panoramic radiographs of patients over 18 years old with healthy, erupted lower premolars were selected. The radiographs were segmented using GIMP, and the dataset was divided into three sets: 70% for model training, 15% for validation, and 15% for testing. Based on the MobileNetV2 architecture, the CNN model extracted 576 attributes from each image, which were then used in conjunction with a decision-tree regression model to estimate age. To evaluate the model's performance, metrics such as Mean Absolute Percentage Error (MAPE), Mean Absolute Error (MAE), Coefficient of Determination and Mean Square Error were used. RESULTS: 3,423 teeth were analyzed, and the patients' mean age was 32.65 years. The overall MAE was 6.52 years (R(2) = 0.67); however, for the age group 31 to 35, the hybrid AI model had an MAE of 0.29 years for the male sample and 0.16 years for the female sample. CONCLUSIONS: The hybrid AI model proved accurate and robust for patients aged 31-35 years; however, in other age groups, the model performed unsatisfactorily, particularly in the 40-50 and 51-55 age ranges. CI - (c) 2026. The Author(s). FAU - Lacerda-Santos, Jhonatan Thiago AU - Lacerda-Santos JT AUID- ORCID: 0000-0003-0295-9939 AD - Department of Dentistry, State University of Paraiba, R. Baraunas, 351, Bairro Universitario, Campina Grande, PB, 58429-500, Brazil. thiiagolacerda@gmail.com. FAU - Paulino, Jose Alberto Souza AU - Paulino JAS AD - Computer Science PhD Student, Federal University of Campina Grande, Rua Aprigio Veloso, 882, Bairro Universitario, Campina Grande, PB, 58429-900, Brazil. FAU - Brito, Hiarles Barreto Sampaio AU - Brito HBS AD - Postgraduate in Oral and Maxillofacial Surgery, State University of Paraiba, R. Baraunas, 351, Bairro Universitario, Campina Grande, PB, 58429-500, Brazil. FAU - Almeida, Fabiana Tolentino AU - Almeida FT AD - College of Dentistry, University of Alberta, 11405 87 Ave NW, Edmonton, AB, T6G 1Z1, Canada. FAU - Bento, Patricia Meira AU - Bento PM AD - College of Dentistry, Department of Dentistry, State University of Paraiba, R. Baraunas, 351, Bairro Universitario, Campina Grande, PB, 58429-500, Brazil. FAU - de Melo, Daniela Pita AU - de Melo DP AD - College of Dentistry, University of Saskatchewan, 105 Wiggins Rd, Saskatoon, SK, S7N 5E5, Canada. LA - eng PT - Journal Article PT - Observational Study DEP - 20260729 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Radiography, Panoramic MH - *Age Determination by Teeth/methods MH - Adult MH - Retrospective Studies MH - *Convolutional Neural Networks MH - Male MH - Regression Analysis MH - Female MH - Cross-Sectional Studies MH - Young Adult MH - Middle Aged MH - Adolescent MH - Brazil MH - *Neural Networks, Computer PMC - PMC13658335 OTO - NOTNLM OT - Age determination by teeth OT - Artificial intelligence OT - Computer Neural Networks OT - Decision trees OT - Panoramic radiography COIS- Declarations. Ethical approval: This study was approved by the Research Ethics Committee of the State University of Paraiba (protocol number 6.700.058) and conducted by the precepts of the Declaration of Helsinki. Informed consent: Not applicable. Competing interests: All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. Clinical trial number: Not applicable. EDAT- 2026/07/29 13:54 MHDA- 2026/10/12 17:30 PMCR- 2026/07/29 CRDT- 2026/07/29 11:13 PHST- 2026/02/07 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:13 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s00414-026-03927-6 [pii] AID - 3927 [pii] AID - 10.1007/s00414-026-03927-6 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):3919-3929. doi: 10.1007/s00414-026-03927-6. Epub 2026 Jul 29. PMID- 42525242 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260923 IS - 1432-1459 (Electronic) IS - 0340-5354 (Print) IS - 0340-5354 (Linking) VI - 273 IP - 8 DP - 2026 Jul 29 TI - Prognostic factors in paediatric-onset multiple sclerosis: a narrative review. LID - 10.1007/s00415-026-14029-z [doi] LID - 495 AB - BACKGROUND: Paediatric-onset multiple sclerosis (POMS) accounts for 3-10% of multiple sclerosis (MS) cases and differs from adult-onset disease in course, treatment response and long-term outcomes. Risk stratification is essential, yet the literature frequently conflates three distinct questions: which children develop MS (susceptibility), which convert from a first demyelinating event (conversion) and which, once diagnosed, will accrue disability (prognosis). OBJECTIVE: This study aimed to provide a narrative overview of candidate prognostic factors in POMS, separated from susceptibility and conversion factors and organised by the outcome each predicts. METHODS: PubMed and Google Scholar were searched (2002-2025, with hand searching of pivotal 2026 cohorts) using a predefined string and full eligibility criteria. Factors were classified along three axes of inference and graded into four evidence tiers (replicated; preliminary; susceptibility rather than prognosis; inconsistent). No formal risk-of-bias assessment was undertaken, consistent with the narrative design. RESULTS: The most reproducible post-diagnosis predictors were early inflammatory activity (relapse number and inter-attack interval in the first two years, annualised relapse rate, early EDSS change), lesion topography (brainstem, spinal cord), T2 lesion accrual, serum neurofilament light chain and treatment-related variables (delayed disease-modifying therapy, early high-efficacy treatment). Advanced MRI metrics, serum glial fibrillary acidic protein and other fluid biomarkers remain preliminary; baseline EDSS was inconsistent. Most dietary, environmental and perinatal exposures relate to susceptibility, not course. CONCLUSIONS: Current evidence supports candidate predictors, not a validated instrument, and inference is further complicated by confounding by indication. A multidimensional, externally validated POMS-specific prognostic score remains to be developed-the aim of the ongoing PROMISING study. CI - (c) 2026. The Author(s). FAU - Achille, Mariaclara AU - Achille M AD - Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari "Aldo Moro", Bari, Italy. FAU - Copetti, Massimiliano AU - Copetti M AD - Unit of Biostatistics, Fondazione IRCCS "Casa Sollievo Della Sofferenza", San Giovanni Rotondo, Italy. FAU - Guerra, Tommaso AU - Guerra T AD - Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari "Aldo Moro", Bari, Italy. FAU - Ferri, Caterina AU - Ferri C AD - Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy. FAU - Iaffaldano, Pietro AU - Iaffaldano P AD - Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari "Aldo Moro", Bari, Italy. FAU - D'Alfonso, Sandra AU - D'Alfonso S AD - University of Piemonte Orientale "Amedeo Avogadro", Novara, Italy. FAU - Pugliatti, Maura AU - Pugliatti M AD - Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy. FAU - Palumbi, Roberto AU - Palumbi R AD - Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. FAU - Simone, Marta AU - Simone M AUID- ORCID: 0000-0003-4381-4613 AD - Child Neuropsychiatry Unit, Department of Precision and Regenerative Medicine, Jonic Area, University of Bari "Aldo Moro", Bari, Italy. marta.simone@uniba.it. LA - eng PT - Journal Article PT - Review DEP - 20260729 PL - Germany TA - J Neurol JT - Journal of neurology JID - 0423161 SB - IM MH - Humans MH - *Multiple Sclerosis/diagnosis MH - Prognosis MH - Child MH - *Disease Progression MH - Age of Onset PMC - PMC13421221 OTO - NOTNLM OT - Disability progression OT - Disease-modifying therapy OT - Paediatric-onset multiple sclerosis OT - Prediction models OT - Prognostic factors OT - Serum neurofilament light chain COIS- Declarations. Conflicts of interest: The authors declare no relevant conflicts of interest pertaining to the content of this review. Ethical approval: Not applicable. This article is a narrative review of previously published literature. Consent to participate: Not applicable. Consent for publication: Not applicable. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/29 CRDT- 2026/07/29 11:12 PHST- 2026/06/18 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:12 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s00415-026-14029-z [pii] AID - 14029 [pii] AID - 10.1007/s00415-026-14029-z [doi] PST - epublish SO - J Neurol. 2026 Jul 29;273(8):495. doi: 10.1007/s00415-026-14029-z. PMID- 42525094 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260923 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 29 TI - Prospective association between baseline ultra-processed food consumption and future adherence to the 24-h movement guidelines in children: findings from the SENDO project. LID - 10.1007/s00431-026-07287-6 [doi] LID - 621 AB - This study evaluates whether baseline ultra-processed food (UPF) consumption predicts failure to meet 24-h movement guidelines at 2-year follow-up in early childhood. Data from 586 participants (aged 4-5 years at baseline) from the SENDO project were analyzed. Dietary intake was assessed through a validated 149-item FFQ, completed by parents, and categorized by NOVA classification. Physical activity, screen time, and sleep time were assessed through questionnaires, based on the 24-h movement guidelines established by the Canadian Society for Exercise Physiology and the WHO. Overall, 92.0% of participants adhered to at least one guideline, 38.9% met all three, and only 8.0% met none of the recommendations. After adjusting for confounders, children in the highest UPF tertile (T3) had a rate ratio (RR) of 1.27 (95% CI 1.04-1.55; p = 0.021) compared with the lowest (T1). A significant linear trend was observed across UPF tertiles (p for trend = 0.022). Moreover, children in T3 had a greater likelihood of not meeting the recreational screen time guideline (RR 1.82, 95% CI 1.18-2.64; p = 0.036) than those in T1. Absolute screen time was significantly higher in T3 than T1 (1.31 +/- 1.11 vs. 0.94 +/- 1.18 h/day; p < 0.001). CONCLUSION: This study suggests that higher UPF consumption is associated with a lower adherence to 24-h movement recommendations-specifically regarding an increased likelihood of not complying with the recreational screen time recommendation. This highlights the importance of reducing UPF intake to support healthy behaviors over time in early life. WHAT IS KNOWN: * Only a limited number of longitudinal studies have investigated the potential long-term association between dietary habits and the 24-h movement guidelines. * Higher consumption of ultra-processed foods (UPFs) is consistently linked to nutrient imbalances and adverse metabolic outcomes in children and adolescents. WHAT IS NEW: * This is the first study to prospectively investigate the relationship between early-life UPF intake and subsequent nonadherence to the 24-h movement guidelines in preschoolers. * Higher baseline UPF intake predicts a lower likelihood of meeting the movement recommendations after a 2-year follow-up, an association primarily driven by increased sedentary screen time. CI - (c) 2026. The Author(s). FAU - Paladino, Nadia AU - Paladino N AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy. FAU - Martinez-Gonzalez, Miguel Angel AU - Martinez-Gonzalez MA AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008, Pamplona, Spain. AD - Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Navarra Institute for Health Research, 31008, Pamplona, Spain. AD - Biomedical Research Network Center for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, 28029, Madrid, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Grosso, Giuseppe AU - Grosso G AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy. FAU - Martin-Calvo, Nerea AU - Martin-Calvo N AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008, Pamplona, Spain. nmartincalvo@unav.es. AD - Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Navarra Institute for Health Research, 31008, Pamplona, Spain. nmartincalvo@unav.es. AD - Pathophysiology of Obesity and Nutrition, Centro de Investigacion Biomedica en Red, Instituto de Salud Carlos III, Madrid, Spain. nmartincalvo@unav.es. LA - eng PT - Journal Article DEP - 20260729 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - Prospective Studies MH - *Fast Foods/statistics & numerical data/adverse effects MH - *Exercise MH - Screen Time MH - Surveys and Questionnaires MH - *Guideline Adherence/statistics & numerical data MH - Sleep Duration MH - Sedentary Behavior MH - Follow-Up Studies PMC - PMC13421281 OTO - NOTNLM OT - Diet OT - Physical activity OT - Preschoolers OT - Screen time OT - Sedentary behavior OT - Sleep duration COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/29 CRDT- 2026/07/29 11:04 PHST- 2026/01/24 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:04 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s00431-026-07287-6 [pii] AID - 7287 [pii] AID - 10.1007/s00431-026-07287-6 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 29;185(8):621. doi: 10.1007/s00431-026-07287-6. PMID- 42525014 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260918 IS - 1980-5497 (Electronic) IS - 1415-790X (Print) IS - 1415-790X (Linking) VI - 29 DP - 2026 TI - Risk and Protective Factor Indicators Management Committee: methodological approach in the construction of indicators of the interagency health information network (Ripsa), 2023. PG - e260026 LID - S1415-790X2026000101025 [pii] LID - 10.1590/1980-549720260026 [doi] LID - e260026 AB - OBJECTIVE: To describe the role of the Risk and Protective Factors Indicator Management Committee (RPF CGI) in the resumption and update of the Interagency Health Information Network (Rede Interagencial de Informacoes para a Saude - Ripsa) indicator matrix in 2023, highlighting the sustainability of data sources and validation processes. METHODS AND RESULTS: Interinstitutional technical meetings were held between 2023 and 2025, involving 36 institutions, to review, define, and validate the indicators using a standardized indicator qualification form. A consensus was reached to use data from the Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey (Sistema de Vigilancia de Fatores de Risco e Protecao para Doencas Cronicas por Inquerito Telefonico - Vigitel), National Study of Infant Feeding and Nutrition (Estudo Nacional de Alimentacao e Nutricao Infantil - Enani), Live Birth Information System (Sistema de Informacoes sobre Nascidos Vivos - Sinasc), National Health Survey (Pesquisa Nacional de Saude - PNS), Household Budget Survey (Pesquisa de Orcamentos Familiares - POF), National School Health Survey (Pesquisa Nacional de Saude do Escolar - PeNSE), National Demographic and Health Survey (Pesquisa Nacional de Demografia e Saude - PNDS), Annual Industrial Survey - Product (Pesquisa Industrial Anual - Produto - PIA-Produto), National Survey on Health and Nutrition (Pesquisa Nacional sobre Saude e Nutricao - PNSN), and National Oral Health Survey (Pesquisa Nacional de Saude Bucal - SB Brasil). The matrix was expanded to 39 indicators, distributed across nine dimensions: noncommunicable chronic diseases, alcohol consumption, smoking, physical activity, nutritional status, dietary intake, childbirth, violence, and oral health. CONCLUSION: The RPF CGI contributed to the qualification and sustainability of Ripsa indicators, which are essential for monitoring public policies, supporting evidence-based decision-making, and addressing health inequalities, aligning with national and international agendas such as the Sustainable Development Goals. FAU - Malta, Deborah Carvalho AU - Malta DC AUID- ORCID: 0000-0002-8214-5734 AD - Universidade Federal de Minas Gerais, School of Nursing, Department of Maternal-Child Nursing and Public Health - Belo Horizonte (MG), Brazil. FAU - Oliveira, Max Moura de AU - Oliveira MM AUID- ORCID: 0000-0002-0804-5145 AD - Universidade Federal de Goias, Instituto de Patologia Tropical e Saude Publica, Department of Collective Health - Goias (GO), Brazil. FAU - Freitas, Mariana Goncalves de AU - Freitas MG AUID- ORCID: 0000-0002-6679-032X AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Antunes, Anna Beatriz Souza AU - Antunes ABS AUID- ORCID: 0000-0001-7813-5421 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Ricardo, Leticia Mendes AU - Ricardo LM AUID- ORCID: 0009-0005-7137-2375 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Tierling, Vera Lucia AU - Tierling VL AUID- ORCID: 0000-0001-9856-2017 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Santos, Debora Franca Dos AU - Santos DFD AUID- ORCID: 0000-0003-3917-2291 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Freitas, Paula Carvalho de AU - Freitas PC AUID- ORCID: 0000-0002-3737-2962 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Oliveira Baldi, Flora Vitoria Serena AU - Oliveira Baldi FVS AUID- ORCID: 0009-0006-7619-1415 AD - Universidade Federal de Minas Gerais, School of Nursing - Belo Horizonte (MG), Brazil. FAU - Carrato, Barbara Aguiar AU - Carrato BA AUID- ORCID: 0000-0001-8102-5741 AD - Universidade Federal de Minas Gerais, School of Nursing - Belo Horizonte (MG), Brazil. FAU - Ferreira, Ana Lorena Lima AU - Ferreira ALL AUID- ORCID: 0000-0003-4236-2651 AD - Ministry of Health, Secretariat of Primary Health Care - Brasilia (DF), Brazil. FAU - Santos, Thanise Sabrina Souza AU - Santos TSS AUID- ORCID: 0000-0003-4087-1815 AD - Ministry of Health, Secretariat of Primary Health Care - Brasilia (DF), Brazil. FAU - Oliveira, Gabriela AU - Oliveira G AUID- ORCID: 0000-0002-2403-5094 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Silva, Isabela da Costa Gaspar da AU - Silva IDCGD AUID- ORCID: 0000-0001-7329-3527 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Menezes-Junior, Luiz Antonio Alves de AU - Menezes-Junior LAA AUID- ORCID: 0000-0002-4497-5358 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Moraes, Luci Fabiane Scheffer AU - Moraes LFS AUID- ORCID: 0000-0003-1034-3878 AD - Ministry of Health, Secretariat of Information and Digital Health - Brasilia (DF), Brazil. CN - Management Committee on Risk and Protective Factors Indicators FAU - Gomes, Gabriella Farias AU - Gomes GF AUID- ORCID: 0000-0001-9118-9694 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Gomes, Julia do Amaral AU - Gomes JA AUID- ORCID: 0000-0001-0002-0003 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Konstantyner, Tulio AU - Konstantyner T AUID- ORCID: 0000-0002-7931-9692 AD - Universidade Federal de Sao Paulo - Sao Paulo (SP), Brazil. FAU - Boing, Alexandra Crispim AU - Boing AC AUID- ORCID: 0000-0001-7792-4824 AD - Universidade Federal de Santa Catarina - Florianopolis (SC), Brazil. FAU - Lara, Joao Victor Ingles de AU - Lara JVI AUID- ORCID: 0000-0001-7079-246X AD - Ministry of Health, Secretariat of Primary Health Care, General Coordination of Oral Health - Brasilia (DF), Brazil FAU - Alves, Luciana Correia AU - Alves LC AUID- ORCID: 0000-0002-8598-4875 AD - Associacao Brasileira de Estudos Populacionais - Campinas (SP), Brazil. FAU - Silva, Josy Maria de Pinho da AU - Silva JMP AUID- ORCID: 0000-0002-7187-1028 AD - World Health Organization, Pan American Health Organization - Brasilia (DF), Brazil. FAU - Szklo, Andre Salem AU - Szklo AS AUID- ORCID: 0000-0003-1903-6188 AD - Instituto Nacional de Cancer - Rio de Janeiro (RJ), Brazil. FAU - Pavao, Ana Luiza Braz AU - Pavao ALB AUID- ORCID: 0000-0002-4122-1796 AD - Fundacao Oswaldo Cruz, Instituto de Comunicacao e Informacao Cientifica e Tecnologica em Saude - Rio de Janeiro (RJ), Brazil. FAU - Fernandes, Hugo AU - Fernandes H AUID- ORCID: 0000-0003-2380-2914 AD - Universidade Federal de Sao Paulo - Sao Paulo (SP), Brazil. FAU - Araujo, Marina Campos AU - Araujo MC AUID- ORCID: 0000-0002-7980-6618 AD - Fundacao Oswaldo Cruz, Instituto de Comunicacao e Informacao Cientifica e Tecnologica em Saude - Rio de Janeiro (RJ), Brazil. FAU - Falcao, Kandice de Melo AU - Falcao KM AUID- ORCID: 0000-0002-6725-6110 AD - Conselho Nacional de Secretarias Municipais de Saude - Brasilia (DF), Brazil. FAU - Marque, Emanuele Souza AU - Marque ES AUID- ORCID: 0000-0002-8633-7290 AD - Universidade do Estado do Rio de Janeiro, Instituto de Medicina Social Hesio Cordeiro - Rio de Janeiro (RJ), Brazil. FAU - Levy, Renata Bertazzi AU - Levy RB AUID- ORCID: 0000-0001-5388-7002 AD - Universidade de Sao Paulo, Faculdade de Medicina - Sao Paulo (SP), Brazil. FAU - Carneiro, Joana Danielle Brandao AU - Carneiro JDB AUID- ORCID: 0000-0003-3629-8091 AD - Ministry of Health, Secretariat of Primary Health Care, Secretariat of Primary Health Care - Brasilia (DF), Brazil. FAU - Carvasan, Gislaine Aparecida Fonsechi AU - Carvasan GAF AUID- ORCID: 0000-0002-1668-9856 AD - Universidade Estadual de Campinas - Campinas (SP), Brazil. FAU - Sampaio, Aline Fernanda Silva AU - Sampaio AFS AUID- ORCID: 0000-0002-9805-2946 AD - Universidade Federal do Acre - Rio Branco (AC), Brazil. FAU - Nunes, Monica da Silva AU - Nunes MS AUID- ORCID: 0000-0002-5078-9121 AD - Universidade Federal de Sao Carlos - Sao Carlos (SP), Brazil. FAU - Boni, Raquel Brandini De AU - Boni RB AUID- ORCID: 0000-0002-2455-5997 AD - Fundacao Oswaldo Cruz, Instituto de Comunicacao e Informacao Cientifica e Tecnologica em Saude - Rio de Janeiro (RJ), Brazil. FAU - Gomes, Crizian Saar AU - Gomes CS AUID- ORCID: 0000-0001-6586-4561 AD - Universidade Federal de Minas Gerais - Belo Horizonte (MG), Brazil. FAU - Boing, Antonio Fernando AU - Boing AF AUID- ORCID: 0000-0001-9331-1550 AD - Universidade Federal de Santa Catarina - Florianopolis (SC), Brazil FAU - Sousa, Juliana Lourenco AU - Sousa JL AUID- ORCID: 0009-0000-4220-128X AD - World Health Organization, Pan American Health Organization, Centro Latino-Americano e do Caribe de Informacao em Ciencias da Saude - Sao Paulo (SP), Brazil. FAU - Gomes, Marilia Miranda Forte AU - Gomes MMF AUID- ORCID: 0000-0001-8584-9676 AD - Associacao Brasileira de Estudos Populacionais - Campinas (SP), Brazil. FAU - Mello, Marcia Sarpa de Campos AU - Mello MSC AUID- ORCID: 0000-0001-8976-4653 AD - Instituto Nacional de Cancer - Rio de Janeiro (RJ), Brazil. FAU - Andrade, Joanlise Marco de Leon AU - Andrade JML AUID- ORCID: 0000-0002-3984-3799 AD - Universidade de Brasilia - Brasilia (DF), Brazil. FAU - Bousquet-Santos, Kelb AU - Bousquet-Santos K AUID- ORCID: 0000-0002-4687-4681 AD - Universidade de Brasilia - Brasilia (DF), Brazil. FAU - Lima, Everton Emanuel Campos de AU - Lima EEC AUID- ORCID: 0000-0001-6275-9854 AD - Universidade Estadual de Campinas - Campinas (SP), Brazil. FAU - Henrique, Rafael dos Santos AU - Henrique RS AUID- ORCID: 0000-0003-3912-5559 AD - Universidade Federal de Pernambuco - Recife (PE), Brazil. LA - eng LA - por PT - Journal Article DEP - 20260727 PL - Brazil TA - Rev Bras Epidemiol JT - Revista brasileira de epidemiologia = Brazilian journal of epidemiology JID - 100954576 SB - IM MH - Humans MH - Brazil MH - Risk Factors MH - *Health Status Indicators MH - *Health Information Systems/organization & administration PMC - PMC13405555 COIS- CONFLICT OF INTERESTS: nothing to declare EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/27 CRDT- 2026/07/29 11:03 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:03 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - S1415-790X2026000101025 [pii] AID - 10.1590/1980-549720260026 [doi] PST - epublish SO - Rev Bras Epidemiol. 2026 Jul 27;29:e260026. doi: 10.1590/1980-549720260026. eCollection 2026. PMID- 42524610 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 0912-0009 (Print) IS - 1880-5086 (Electronic) IS - 0912-0009 (Linking) VI - 79 IP - 1 DP - 2026 Jul 1 TI - Trace elements in relation to glycemic control and disease complications in children living with type 1 diabetes mellitus. PG - 86-96 LID - 10.3164/jcbn.26-3 [doi] AB - Trace elements such as copper, zinc, and magnesium are essential for antioxidant defense, insulin action and glucose homeostasis, yet their clinical utility as biomarkers in childhood type 1 diabetes mellitus remains uncertain. We conducted a case-control study of 199 Egyptian children aged 5-18 years (100 with type 1 diabetes mellitus and 99 non-diabetic controls) attending the National Nutrition Center. Anthropometry, lifestyle characteristics and biochemistry were assessed, and serum copper, zinc, and magnesium were measured by atomic absorption; the copper to zinc ratio was calculated. Children with type 1 diabetes mellitus had significantly lower zinc and magnesium concentrations and higher copper to zinc ratios than controls, while mean copper levels did not differ significantly. Lower magnesium and zinc, higher body mass index, elevated triglycerides, and reduced physical activity were independently associated with type 1 diabetes mellitus. In receiver operating characteristic analyses, magnesium showed the best discriminative performance between diabetic and control children, whereas zinc and the copper to zinc ratio were highly specific markers of poor glycemic control, and zinc deficiency and reduced estimated glomerular filtration rate were consistently associated with microvascular complications. These findings support trace-element monitoring to refine risk stratification and management in pediatric type 1 diabetes mellitus. CI - Copyright (c) 2026 JCBN. FAU - Ibrahim, Randa AU - Ibrahim R AD - Clinical and Chemical Pathology Department, National Nutrition Institute, The General Organization for Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt. FAU - Mohamed, Amal Ahmed AU - Mohamed AA AD - Biochemistry and Molecular Biology Department, National Hepatology and Tropical Medicine Research Institute, The General Organization for Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt. FAU - Abbas, Enas Sayed AU - Abbas ES AD - Pediatric Clinical Nutrition Department, National Nutrition Institute, The General Organization for Teaching Hospitals and Institutes (GOTHI), Egypt. FAU - Sultan, Eman AU - Sultan E AD - Department of Endocrinology, National Nutrition Institute, The General Organization for Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt. FAU - Selim, May Mohsen Samy AU - Selim MMS AD - Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Samy, Lamees Ahmed AU - Samy LA AD - Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Fahmy, Eman M AU - Fahmy EM AD - Endocrinology & Metabolism, Internal Medicine Department, Faculty of Medicine, Capital University, Cairo, Egypt. FAU - Saad, Mohamed AbdelFattah Ibrahim AU - Saad MAI AD - Pediatric Department, Almataria Teaching Hospital, The General Organization for Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt. FAU - Anwer, Omnia M AU - Anwer OM AD - Public Health and Community Medicine Department, Faculty of Medicine, Benha University, Benha, Qalyubiyah Governorate, Egypt. FAU - Girgiss, Mina Wassef AU - Girgiss MW AD - Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt. FAU - El Sherbiny, Mohamed AU - El Sherbiny M AD - Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Batota, Yasser AU - Batota Y AD - NMC Royal Hospital, Khalifa City, Abu Dhabi, United Arab Emirates. FAU - Mohammad, Rahmathullah AU - Mohammad R AD - NMC Royal Hospital, Khalifa City, Abu Dhabi, United Arab Emirates. FAU - Hafez, Wael AU - Hafez W AD - Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt. AD - NMC Royal Hospital, Khalifa City, Abu Dhabi, United Arab Emirates. AD - College of Medicine and Health Science, Khalifa University, Abu Dhabi, United Arab Emirates. AD - The Emirates Society of Internal Medicine (ESIM), Emirates Medical Association, 46th Street Deira Near International Bowling Centre, Dubai, United Arab Emirates. LA - eng PT - Journal Article DEP - 20260428 PL - Japan TA - J Clin Biochem Nutr JT - Journal of clinical biochemistry and nutrition JID - 8700907 PMC - PMC13412591 OTO - NOTNLM OT - copper to zinc ratio OT - magnesium OT - trace elements OT - type 1 diabetes mellitus OT - zinc COIS- No potential conflicts of interest were disclosed. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/04/28 CRDT- 2026/07/29 10:40 PHST- 2026/01/05 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 10:40 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - DN/JST.JSTAGE/jcbn/26-3 [pii] AID - 10.3164/jcbn.26-3 [doi] PST - ppublish SO - J Clin Biochem Nutr. 2026 Jul 1;79(1):86-96. doi: 10.3164/jcbn.26-3. Epub 2026 Apr 28. PMID- 42524434 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2472-0054 (Electronic) IS - 2472-0054 (Linking) VI - 11 IP - 4 DP - 2026 Jul-Aug TI - Enhancing Pediatric Obesity Management through Quality Improvement: A Hybrid Approach to Intensive Health Behavior and Lifestyle Treatment in Primary Care. PG - e892 LID - 10.1097/pq9.0000000000000892 [doi] LID - e892 AB - INTRODUCTION: Intensive health behavior and lifestyle treatment (IHBLT) programs can improve weight and reduce comorbidities for children with obesity, but implementation in primary care remains limited. Baseline performance at our institution showed low referral volume, limited participation, and insufficient treatment intensity, indicating gaps in program reach and adoption. METHODS: Utilizing the model for improvement, we led a quality improvement initiative in a large urban academic primary care clinic to increase IHBLT referrals, participation, and treatment intensity. Sequential plan-do-study-act cycles tested provider education, standardized and culturally tailored materials, a hybrid in-person-and-virtual program structure, and engagement strategies. We tracked three process measures: referrals, participation, and program intensity. We tracked outcomes using individuals-moving-range (X-mR) statistical process control charts. RESULTS: Statistical process control analysis demonstrated that program participation and intervention intensity met Provost criteria for a sustained shift, whereas referral volume demonstrated primarily common-cause variation. Improvements in participation and intervention intensity were maintained over time, with centerlines recalculated to reflect updated process performance. Moving range charts indicated stable variation across all measures. CONCLUSIONS: An iterative, context-responsive system redesign improved the delivery of evidence-based pediatric obesity treatment in our primary care setting. The hybrid IHBLT model, combining in-person visits and technology-supported touchpoints, was associated with sustained gains in participation and treatment intensity, whereas referral volume remained stable. This pragmatic approach leverages existing resources and offers a feasible pathway for primary care clinics seeking to implement guideline-concordant IHBLT while addressing common logistical and equity-related barriers. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Skrocki, Emily T AU - Skrocki ET AD - From the Children's Hospital Colorado, Aurora, Colo. AD - College of Nursing, University of Colorado, Anschutz Medical Campus, Aurora, Colo. FAU - Sarabia, Cristian AU - Sarabia C AD - From the Children's Hospital Colorado, Aurora, Colo. AD - College of Nursing, University of Colorado, Anschutz Medical Campus, Aurora, Colo. FAU - Xiong, Shengh AU - Xiong S AD - From the Children's Hospital Colorado, Aurora, Colo. AD - Division of Child and Adolescents, Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colo. FAU - Talmi, Ayelet AU - Talmi A AD - From the Children's Hospital Colorado, Aurora, Colo. AD - Division of Child and Adolescents, Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colo. LA - eng PT - Journal Article DEP - 20260728 PL - United States TA - Pediatr Qual Saf JT - Pediatric quality & safety JID - 101702480 PMC - PMC13412649 COIS- Disclosure: The authors have no financial interest to declare in relation to the content of this article. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/28 CRDT- 2026/07/29 10:35 PHST- 2025/10/22 00:00 [received] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 10:35 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - PQS-D-25-00161 [pii] AID - 10.1097/pq9.0000000000000892 [doi] PST - epublish SO - Pediatr Qual Saf. 2026 Jul 28;11(4):e892. doi: 10.1097/pq9.0000000000000892. eCollection 2026 Jul-Aug. PMID- 42524307 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2197-1153 (Print) IS - 2197-1153 (Electronic) IS - 2197-1153 (Linking) VI - 13 IP - 3 DP - 2026 Jul TI - Postoperative computed tomography-derived bundle morphology ratios are associated with noncontact graft failure after double-bundle anterior cruciate ligament reconstruction in adolescents. PG - e70864 LID - 10.1002/jeo2.70864 [doi] LID - e70864 AB - PURPOSE: To evaluate whether postoperative computed tomography (CT)-derived bundle-specific morphology ratios are associated with noncontact graft failure following anatomic double-bundle anterior cruciate ligament (ACL) reconstruction in adolescents. METHODS: This single-centre retrospective cohort study included 133 consecutive patients aged 15-19 years who underwent primary anatomic double-bundle ACL reconstruction with routine postoperative CT at 1 week postoperatively and a minimum follow-up of 24 months; all patients had a complete 2-year outcome assessment. Patients with a lateral femoral condyle ratio (LFCR) >/= 62.18% were excluded, as this threshold has been associated with substantially elevated graft rerupture risk [2]. Only noncontact graft failures within 2 years were considered events. Preoperative MRI was used to assess femoral morphology, and postoperative CT was used to quantify anteromedial (AMR) and posterolateral (PLR) bundle morphology ratios. Receiver operating characteristic analysis and multivariable logistic regression were performed to evaluate discriminative ability and independent associations with graft failure. RESULTS: Both AMR and PLR were significantly associated with graft failure and demonstrated moderate-to-good discriminative ability (area under the curve 0.804 and 0.799, respectively). In multivariable analysis adjusting for age, sex, BMI, activity level and meniscal injury status, only AMR remained associated with graft failure in an exploratory multivariable model (OR: 1.15 per 0.01-unit increase, 95% CI: 1.02-1.31; p = 0.026). Intraobserver reliability was good to excellent across all parameters (intraclass correlation coefficients 0.878-0.949). CONCLUSION: Postoperative CT-derived bundle morphology ratios are associated with noncontact graft failure following anatomic double-bundle ACL reconstruction, with AMR bundle morphology demonstrating the strongest association in an exploratory multivariable model. These preliminary findings suggest that quantitative morphology ratios may be useful for future risk stratification, but prospective validation is required before clinical implementation. LEVEL OF EVIDENCE: Level III, retrospective cohort study. CI - (c) 2026 The Author(s). Journal of Experimental Orthopaedics published by John Wiley & Sons Ltd on behalf of European Society of Sports Traumatology, Knee Surgery and Arthroscopy. FAU - Takeuchi, Yuko AU - Takeuchi Y AUID- ORCID: 0009-0005-7009-5628 AD - Department of Orthopedic Surgery Asahi University Hospital Gifu Japan. FAU - Kawai, Ryosuke AU - Kawai R AD - Department of Orthopedic Surgery Asahi University Hospital Gifu Japan. FAU - Hiraiwa, Hideki AU - Hiraiwa H AD - Department of Orthopedic Surgery Asahi University Hospital Gifu Japan. FAU - Tsukahara, Takashi AU - Tsukahara T AD - Department of Orthopedic Surgery Asahi University Hospital Gifu Japan. LA - eng PT - Journal Article DEP - 20260728 PL - United States TA - J Exp Orthop JT - Journal of experimental orthopaedics JID - 101653750 PMC - PMC13410946 OTO - NOTNLM OT - anterior cruciate ligament OT - double-bundle reconstruction OT - graft failure OT - imaging morphology OT - risk prediction COIS- The authors declare no conflict of interest. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/28 CRDT- 2026/07/29 10:31 PHST- 2026/04/09 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 10:31 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - JEO270864 [pii] AID - 10.1002/jeo2.70864 [doi] PST - epublish SO - J Exp Orthop. 2026 Jul 28;13(3):e70864. doi: 10.1002/jeo2.70864. eCollection 2026 Jul. PMID- 42524086 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260927 IS - 2090-6749 (Print) IS - 2090-6757 (Electronic) IS - 2090-6757 (Linking) VI - 2026 DP - 2026 TI - Recurrent Aneurysmal Bone Cyst in the Metacarpal of a Child Treated With Endoscopic Curettage: A Case Report. PG - 6616065 LID - 10.1155/cro/6616065 [doi] LID - 6616065 AB - CASE: A 5-year-old boy presented with right-hand pain and was diagnosed with a bone tumor in his fifth metacarpal. Because the patient wished to resume sports activities, endoscopic curettage (ESC) was performed. The pathological diagnosis of the tumor was aneurysmal bone cyst (ABC). As recurrence was observed 1 year after the first ESC, a second ESC was performed. Postoperatively, the bone healed without complications, allowing the patient to resume physical activity. CONCLUSION: ESC can be performed in a tiny metacarpal of a child. The endoscopic treatment may be a feasible treatment option for ABCs in the hand. CI - Copyright (c) 2026 Yusuke Hattori et al. Case Reports in Orthopedics published by John Wiley & Sons Ltd. FAU - Hattori, Yusuke AU - Hattori Y AUID- ORCID: 0000-0003-3626-086X AD - Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, nagoya-cu.ac.jp. FAU - Kawaguchi, Yohei AU - Kawaguchi Y AUID- ORCID: 0000-0002-0354-5810 AD - Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, nagoya-cu.ac.jp. FAU - Kimura, Hiroaki AU - Kimura H AD - Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, nagoya-cu.ac.jp. FAU - Aiba, Hisaki AU - Aiba H AD - Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, nagoya-cu.ac.jp. FAU - Okamoto, Hideki AU - Okamoto H AD - Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, nagoya-cu.ac.jp. FAU - Murakami, Hideki AU - Murakami H AD - Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, nagoya-cu.ac.jp. LA - eng PT - Journal Article DEP - 20260316 PL - United States TA - Case Rep Orthop JT - Case reports in orthopedics JID - 101591806 PMC - PMC13409334 COIS- The authors declare no conflicts of interest. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/03/16 CRDT- 2026/07/29 10:25 PHST- 2025/01/31 00:00 [received] PHST- 2026/02/06 00:00 [revised] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 10:25 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - CRO6616065 [pii] AID - 10.1155/cro/6616065 [doi] PST - epublish SO - Case Rep Orthop. 2026 Mar 16;2026:6616065. doi: 10.1155/cro/6616065. eCollection 2026. PMID- 42524052 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 0974-7052 (Print) IS - 0975-1904 (Electronic) IS - 0974-7052 (Linking) VI - 19 IP - 6 DP - 2026 Jun TI - Evaluation of Screen Time, Oral Health Status, and Sleep Disturbances in Children between 6 and 13 years: A Cross-sectional Study. PG - 711-717 LID - 10.5005/jp-journals-10005-3538 [doi] AB - BACKGROUND: Sleep is a critical component required for the growth and development of a child. Deviation from the normal sleep pattern, quality, and quantity directly affects the baseline functioning of the individual. Increased screen time exposure affects the overall well-being of the child, particularly the sleep and oral health. AIM: To assess the average screen time exposure, oral health status, and prevalence of sleep disorders in children between 6 and 13 years of age. MATERIALS AND METHODS: This cross-sectional study included 370 children visiting the Department of Pediatric and Preventive Dentistry between July 2024 and January 2025. Data were collected using a validated screen time questionnaire and the Sleep Disturbance Scale for Children. Dental caries was assessed using the ICDAS II index. The descriptive statistics were reported in the form of mean and standard deviation. ANOVA, bivariate, and multivariate linear regression analyses were performed. Statistical significance was noted when the p-value was 0.90), including parent-reported toe-walking percentage, satisfaction, treatment adherence, pain-on-activity, and clinician-reported gait scale. Validity analyses showed significant and meaningful correlations between iTWO proforma-T items and established measures. The estimated toe-walking percentage correlated strongly with the Toe Walking Severity Scale (rho = -0.549) and the OxAFQ emotional domain (rho = -0.493). Functional performance items (gait scale, 2- and 6-minute walk tests) showed moderate positive correlations with toe-walking severity, whereas pain-related items correlated negatively with relevant PODCI and OxAFQ domains. CONCLUSION: The iTWO proforma-T is a valid and reliable instrument for evaluating symptoms, functional status, and treatment-related outcomes in children with idiopathic toe walking. The tool preserves the structure and measurement characteristics of the original proforma and can be confidently used by clinicians and researchers for evidence-based assessment and follow-up in Turkish-speaking pediatric populations. CI - (c) 2026 The Author(s). Journal of Foot and Ankle Research published by John Wiley & Sons Australia, Ltd on behalf of Australian Podiatry Association and The Royal College of Podiatry. FAU - Giray, Esra AU - Giray E AUID- ORCID: 0000-0003-3895-4486 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Karadag, Munteha Ilkyaz AU - Karadag MI AUID- ORCID: 0009-0001-6500-3072 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkiye. FAU - Turkyilmaz, Sude Gozukucuk AU - Turkyilmaz SG AUID- ORCID: 0009-0008-2381-4089 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Celik, Kubra Yildiz AU - Celik KY AUID- ORCID: 0009-0002-1920-5682 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Akpinar, Pinar AU - Akpinar P AUID- ORCID: 0000-0002-7796-0750 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Illeez, Ozge Gulsum AU - Illeez OG AUID- ORCID: 0000-0002-3824-4428 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Unlu Ozkan, Feyza AU - Unlu Ozkan F AUID- ORCID: 0000-0002-7686-1347 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Aktas, Ilknur AU - Aktas I AUID- ORCID: 0000-0002-1050-9666 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Karadag-Saygi, Evrim AU - Karadag-Saygi E AUID- ORCID: 0000-0002-7420-9902 AD - Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkiye. FAU - Williams, Cylie M AU - Williams CM AUID- ORCID: 0000-0002-0223-9141 AD - School of Primary and Allied Health Care, Monash University, Peninsula Campus, Frankston, Victoria, Australia. LA - eng PT - Journal Article PT - Validation Study PL - United States TA - J Foot Ankle Res JT - Journal of foot and ankle research JID - 101471610 SB - IM MH - Humans MH - Child MH - Reproducibility of Results MH - Female MH - Child, Preschool MH - Male MH - Adolescent MH - *Toes/physiopathology MH - Turkey MH - *Walking/physiology MH - Surveys and Questionnaires MH - Severity of Illness Index MH - Psychometrics MH - *Movement Disorders/physiopathology/diagnosis MH - Treatment Outcome PMC - PMC13415977 OTO - NOTNLM OT - 6-minute walk test OT - Toe Walking Severity Scale OT - idiopathic toe walking OT - treatment outcomes OT - weight-bearing lunge COIS- The authors declare no conflicts of interest. EDAT- 2026/07/29 06:35 MHDA- 2026/07/29 18:39 PMCR- 2026/07/28 CRDT- 2026/07/29 01:43 PHST- 2026/07/07 00:00 [revised] PHST- 2026/02/16 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/29 18:39 [medline] PHST- 2026/07/29 06:35 [pubmed] PHST- 2026/07/29 01:43 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - JFA270188 [pii] AID - 10.1002/jfa2.70188 [doi] PST - ppublish SO - J Foot Ankle Res. 2026 Sep;19(3):e70188. doi: 10.1002/jfa2.70188. PMID- 42522101 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260912 IS - 1365-2036 (Electronic) IS - 0269-2813 (Print) IS - 0269-2813 (Linking) VI - 64 IP - 7 DP - 2026 Oct TI - Review Article: Accelerating Coeliac Disease Clinical Trials-Beyond Celiac Meeting With Industry, Academics, Patients and the FDA. PG - 890-896 LID - 10.1111/apt.70873 [doi] AB - BACKGROUND: Coeliac disease is due to an acquired, lifelong gluten-specific immune response resulting in a gluten-dependent chronic immune-mediated enteropathy associated with gastrointestinal and extraintestinal morbidity. Strictly avoiding dietary gluten is the only available management but has never been subjected to rigorous efficacy assessment now required for a pharmaceutical agent. Gluten-free diet (GFD) is partially and inconsistently effective, but it places a high burden on patients, families, the food industry, and regulators and is defined inconsistently around the world, highlighting the need for effective and convenient adjunctive pharmacological therapies. AIMS: To summarize key patient, scientific, and regulatory considerations for coeliac disease drug development based on a multi-stakeholder meeting focused on accelerating clinical trials. METHODS: A pre-competitive meeting convened by the Beyond Celiac Coalition (May 2024) included patients with coeliac disease, academic experts, pharmaceutical industry representatives, and participants from the US Food and Drug Administration. Moderated panel addressed patient priorities, symptom and histologic endpoints, biopsy and histology methods, gluten challenge design, clinical trial duration, and regulatory expectations. Themes were synthesized qualitatively with focus on trial design implications and unresolved questions. RESULTS: Participants described high symptom burden and psychosocial impact despite gluten-free diet adherence underscoring unmet therapeutic need in coeliac disease. Regulatory perspectives emphasized the need for clinically meaningful improvement and evidence of intestinal benefit, framed as symptom and histology co-primary endpoints in clinical trials. These expectations were discussed as most applicable to trial populations with both clinically meaningful symptoms and active histologic injury at baseline; for other phenotypes, it was emphasized that endpoint strategy, the role of gluten exposure, and trial duration should be tailored case by case to the population and mechanism of action. Practical challenges identified included endpoint selection and definition, discordance between symptoms and histology, selecting fit-for-purpose symptom measures; standardizing biopsy acquisition and central histology reads to address patchiness and variability, pre-specifying definitions of meaningful histologic change given ongoing uncertainty about healing, and trial feasibility. Controlled gluten exposure was discussed as a tool to improve interpretability of efficacy outcomes, with careful consideration of dose, duration, patient burden and safety. Discussion addressed the ideal length of the double-blind period, including a shorter 24-week double-blind study with an open-label extension versus a 52-week double-blind design. Trial duration should balance scientific rigour, patient retention, and the need for longer-term safety and durability data, with flexibility to tailor the approach to context. CONCLUSIONS: Progress in coeliac disease drug development will require patient-centred, scientifically robust but feasible trial designs with appropriate endpoints, justified use of gluten exposure, consideration of improved biomarkers to reduce patient burden and early regulatory engagement. Continued multi-stakeholder collaboration, including dedicated consideration of paediatric drug development, is essential to advance effective therapies. CI - (c) 2026 The Author(s). Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd. FAU - Fahey, Lisa M AU - Fahey LM AUID- ORCID: 0009-0009-5823-425X AD - Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Anderson, Robert AU - Anderson R AD - International Society for the Study of Celiac Disease, Groningen, the Netherlands. AD - Mackay Base Hospital, Mackay, Queensland, Australia. FAU - Liu, Edwin AU - Liu E AD - Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Murray, Joseph A AU - Murray JA AUID- ORCID: 0000-0003-1941-9090 AD - Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA. FAU - Robert, Marie E AU - Robert ME AUID- ORCID: 0000-0002-6385-4578 AD - Yale University School of Medicine, New Haven, Connecticut, USA. FAU - Silvester, Jocelyn Anne AU - Silvester JA AUID- ORCID: 0000-0002-3615-1666 AD - Boston Children's Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Avery, Kate AU - Avery K AD - Beyond Celiac, Ambler, Pennsylvania, USA. FAU - Cheinquer, Nelson AU - Cheinquer N AD - Takeda, Cambridge, Massachusetts, USA. FAU - Grebe, Kristie AU - Grebe K AD - Anokion, Cambridge, Massachusetts, USA. AD - Navigator Medicines, Cambridge, Massachusetts, USA. FAU - Tulabandula, Bhargav AU - Tulabandula B AD - Takeda, Cambridge, Massachusetts, USA. FAU - Leffler, Daniel A AU - Leffler DA AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Chugai Pharmaceuticals, Berkeley Height, New Jersey, USA. CN - Beyond Celiac Coalition LA - eng PT - Journal Article PT - Review DEP - 20260728 PL - England TA - Aliment Pharmacol Ther JT - Alimentary pharmacology & therapeutics JID - 8707234 SB - IM MH - *Celiac Disease/diet therapy/drug therapy MH - Humans MH - *Diet, Gluten-Free MH - United States MH - *Clinical Trials as Topic MH - United States Food and Drug Administration MH - *Drug Development PMC - PMC13559503 OTO - NOTNLM OT - Beyond Celiac Coalition OT - Food and Drug Administration OT - coeliac disease OT - drug development COIS- Lisa M. Fahey: None. Robert Anderson: Shareholder and Director, Novoviah Pharmaceuticals Pty. Ltd., Brisbane Queensland Australia. No grants; Shareholder and Director, JM Clinical Pty Ltd, Brisbane, Queensland Australia. No grants; Consultant to: Topas Therapeutics GmbH, Hamburg, Germany; Takeda Pharmaceutical Company Ltd/Millennium Pharmaceuticals, Cambridge MA USA; Forte Bioscience Inc., Dallas TX, USA; Barinthus Biotherapeutics, Germantown, MD, USA; Immunic AG, Grafelfing, Germany; Universal Cells-ASTELLAS LLC US, Seattle, WA, USA; AMYRA Biotech AG, Basel, Switzerland; DBV, Paris, France; EVOQ Therapeutics, Ann Arbor, MI, USA; Kanyos Bio Inc., Cambridge, MA, USA; Kerna Ventures; Catalys Pacific; Georgiamune Inc.; Sonoma Biotherapeutics Inc., South San Francisco, CA, USA; Switchback Therapeutics Inc.; TregTherapeutics Inc., NC, USA. Edwin Liu: Takeda consultant, UpToDate contributor. Joseph A. Murray: None. Marie E. Robert: Consultant for Takeda, Anokion, Alimentiv, Teva, BMS. Salary support from AstraZeneca. Jocelyn Anne Silvester: Consulting (last 5 years): Alimentiv, Chugai Pharmaceuticals, GLG, Guidepoint, Lumanity, Takeda Pharmaceuticals, Teva Pharmaceuticals. Research Grants to Institution (last 5 years): Amgen, Glutenostics LLC, Janssen, Milky Way Life Sciences, Takeda Pharmaceuticals. Foundation Grants (last 5 years): Allan Foundation, American College of Gastroenterology, Beyond Celiac, Celiac Disease Foundation, Chan Zuckerburg Initiative, Global Autoimmune Institute, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Kate Avery: Consultant to Chugai Pharmaceuticals. Nelson Cheinquer: Employee of Takeda Development Center Americas and is a stockholder in Takeda Pharmaceutical Company Limited. Kristie Grebe: At time of the meeting, was an Anokion employee and shareholder, currently Navigator Medicines employee and shareholder. Bhargav Tulabandula: Employee of Takeda Development Center Americas and is a stockholder in Takeda Pharmaceutical Company Limited. Daniel A. Leffler: Employee of Chugai Pharma; Board Member of Foundation for Celiac Disease Outcome Measures. Potential conflicts of interest are outlined above in the disclosure section. EDAT- 2026/07/29 06:35 MHDA- 2026/09/10 11:54 PMCR- 2026/09/10 CRDT- 2026/07/29 00:23 PHST- 2026/07/13 00:00 [revised] PHST- 2025/09/05 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/09/10 11:54 [medline] PHST- 2026/07/29 06:35 [pubmed] PHST- 2026/07/29 00:23 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - APT70873 [pii] AID - 10.1111/apt.70873 [doi] PST - ppublish SO - Aliment Pharmacol Ther. 2026 Oct;64(7):890-896. doi: 10.1111/apt.70873. Epub 2026 Jul 28. PMID- 42521910 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260819 IS - 1539-0829 (Electronic) IS - 1534-4827 (Print) IS - 1534-4827 (Linking) VI - 26 IP - 1 DP - 2026 Jul 29 TI - Insulin-Related Disordered Eating Behaviour: A Scoping Review of Evidence. LID - 10.1007/s11892-026-01637-2 [doi] LID - 23 AB - PURPOSE OF REVIEW: Current understanding of insulin-related disordered eating behaviour is limited by inconsistencies in terminology and measurement. Prevalence of the behaviour and characteristics of individuals are unclear. How best to intervene and with whom is therefore unknown. This scoping review summarises existing knowledge as a first step to addressing the problem. Eligible sources investigated individuals with T1D restricting or inflating insulin with disordered eating motivations. Charted data included study aims, sample characteristics, measures, and key findings. RECENT FINDINGS: Samples converged on adolescent females in USA, Canada and western Europe. Numerous measures were used, few had received extensive validation. Prevalence estimates, and models of development and maintenance were inconsistent. The validity and generalisability of measures should be improved, particularly so that diverse perspectives (e.g., males, non-Western cultures), so far overlooked, are captured. Identity and social relationships appeared particularly important in the development and maintenance of insulin-related disordered eating behaviour and recovery, and could be a potential target for interventions. CI - (c) 2026. The Author(s). FAU - Shelford, Amy AU - Shelford A AUID- ORCID: 0000-0002-2666-1144 AD - School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights Campus, RG6 6ES, Reading, England. a.shelford@pgr.reading.ac.uk. FAU - Jenkins, Paul E AU - Jenkins PE AUID- ORCID: 0000-0003-1673-2903 AD - School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights Campus, RG6 6ES, Reading, England. FAU - Harvey, Kate AU - Harvey K AUID- ORCID: 0000-0002-6819-0934 AD - School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights Campus, RG6 6ES, Reading, England. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260729 PL - United States TA - Curr Diab Rep JT - Current diabetes reports JID - 101093791 RN - 0 (Insulin) SB - IM MH - Humans MH - *Feeding and Eating Disorders/epidemiology/chemically induced/psychology MH - *Insulin/adverse effects/administration & dosage MH - Female MH - *Diabetes Mellitus, Type 1/drug therapy/psychology MH - *Feeding Behavior/psychology PMC - PMC13415336 OTO - NOTNLM OT - Type 1 diabetes OT - insulin inflation OT - insulin restriction OT - insulin-related disordered eating behaviour COIS- Declarations. Human or Animal Rights: This article does not contain any studies with human or animal subjects performed by any of the authors. Competing interests: The authors declare no competing interests. EDAT- 2026/07/29 00:35 MHDA- 2026/07/29 18:39 PMCR- 2026/07/29 CRDT- 2026/07/28 23:23 PHST- 2025/09/17 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/07/29 18:39 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 23:23 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s11892-026-01637-2 [pii] AID - 1637 [pii] AID - 10.1007/s11892-026-01637-2 [doi] PST - epublish SO - Curr Diab Rep. 2026 Jul 29;26(1):23. doi: 10.1007/s11892-026-01637-2. PMID- 42521566 OWN - NLM STAT- Publisher LR - 20260728 IS - 1526-0550 (Electronic) IS - 1526-0542 (Linking) DP - 2026 Jul 17 TI - Travelling with a child on ventilatory support: How to plan and avoid potential pitfalls. LID - S1526-0542(26)00060-6 [pii] LID - 10.1016/j.prrv.2026.07.002 [doi] AB - Travel for families of children with complex medical needs can offer significant benefits for family wellbeing and quality of life, yet it is often perceived as complex and high risk. As the population of technology-dependent children increases, the need to support safe and feasible travel has become more prominent. Families face multiple barriers, including the need to maintain continuity of care, transport essential equipment and medications, navigate variable regulations, and coordinate extensive documentation across healthcare and travel systems. These demands, alongside financial costs and administrative burden, frequently contribute to increased anxiety and risk aversion. Experiential accounts from parents demonstrate that travel for this cohort of children is safe, achievable, and rewarding with comprehensive and anticipatory planning across key domains, including destination selection, accommodation suitability, equipment and oxygen provision, medication and nutrition management, transport arrangements, and emergency preparedness. Healthcare professionals play a crucial role in supporting families through pre-travel assessment, documentation, and risk mitigation strategies. With appropriate preparation and multidisciplinary collaboration, travel can be undertaken safely, enabling families to access important psychosocial benefits while minimising potential clinical risks. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Carluke, R AU - Carluke R AD - Wellchild Charity, Sunningend Business Centre 22 Lansdown Industrial Estate, Cheltenham Gloucestershire, GL51 8P, UK. FAU - Davies, P AU - Davies P AD - Department of Paediatric Respiratory & Sleep Medicine, Royal Hospital for Children, Glasgow, Govan Road, G51 4TF, UK. FAU - Langley, R J AU - Langley RJ AD - Department of Paediatric Respiratory & Sleep Medicine, Royal Hospital for Children, Glasgow, Govan Road, G51 4TF, UK. Electronic address: ross.langley@nhs.scot. LA - eng PT - Journal Article PT - Review DEP - 20260717 PL - England TA - Paediatr Respir Rev JT - Paediatric respiratory reviews JID - 100898941 SB - IM OTO - NOTNLM OT - Children with complex medical needs OT - Holidays OT - Technology-dependent children OT - Travel OT - Ventilated children COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/29 00:35 MHDA- 2026/07/29 00:35 CRDT- 2026/07/28 21:57 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/29 00:35 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 21:57 [entrez] AID - S1526-0542(26)00060-6 [pii] AID - 10.1016/j.prrv.2026.07.002 [doi] PST - aheadofprint SO - Paediatr Respir Rev. 2026 Jul 17:S1526-0542(26)00060-6. doi: 10.1016/j.prrv.2026.07.002. PMID- 42521237 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 35 IP - 4 DP - 2026 Aug TI - Association between factor analysis-derived dietary patterns at 24 months of age and allergic diseases in toddlers. PG - 735-748 LID - 10.6133/apjcn.202608_35(4).0017 [doi] AB - BACKGROUND AND OBJECTIVES: Early-life diet may influence immune development and the risk of allergic diseases. This study investigated associations between dietary patterns at 24 months of age and allergic diseases in Korean toddlers. METHODS AND STUDY DESIGN: In this cross-sectional study, 433 toddlers from the Korean Mothers and Children's Environmental Health (MOCEH) cohort were included. Dietary intake was assessed using two non-consecutive 24-hour recalls. Factor analysis of 26 food groups identified dietary patterns, and individual pattern scores were categorized into tertiles based on ascending distribution. Allergic diseases were determined by caregiver questionnaires. Multivariable logistic regression was used to assess associations, adjusting for confounders. RESULTS: Three dietary patterns were identified: Pattern 1 (white rice, kimchi, and non-salt-preserved vegetables), Pattern 2 (seasoning, butter, and meat), and Pattern 3 (milk and dairy products). Compared with the lowest tertile, the highest tertile of Pattern 2 was associated with higher odds of other allergic diseases (OR: 7.55; 95% CI: 1.62-35.23), and any allergic disease (OR: 2.03; 95% CI: 1.10-3.73). Pattern 3 was inversely associated with atopic dermatitis (OR: 0.51; 95% CI: 0.27-0.98), while Pattern 1 showed no significant association. CONCLUSIONS: Early childhood dietary patterns may influence the development of allergic disease. A pattern characterized by seasoning, butter, and meat was associated with an increased risk of allergic disease, whereas a dairy-based pattern was inversely associated with atopic dermatitis in Korean toddlers. FAU - Son, Hyoyeon AU - Son H AD - Department of Food and Nutrition, Wonkwang University, Iksan, Korea. FAU - Hong, Weiqi AU - Hong W AD - Graduate Program in System Health Science and Engineering, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. AD - Department of Environmental Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea. AD - Institute of Ewha-SCL for Environmental Health (IESEH), College of Medicine, Ewha Womans University, Seoul, Republic of Korea. AD - Department of Medical Science, College of Medicine, Ewha Medical Research Institute, Ewha Womans University, Seoul, Republic of Korea. FAU - Jang, Won AU - Jang W AD - Department of Food Science and Nutrition, Dongseo University, Busan, Republic of Korea. Email: jangwon@gdsu.dongseo.ac.kr. FAU - Kim, Hyesook AU - Kim H AD - Department of Food and Nutrition, Wonkwang University, Iksan, Korea. Email: hskim81@wku.ac.kr. AD - Institute for Better Living, Wonkwang University, Iksan, Korea. LA - eng PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 SB - IM MH - Humans MH - *Hypersensitivity/epidemiology MH - Cross-Sectional Studies MH - Female MH - *Diet MH - Male MH - Child, Preschool MH - Republic of Korea/epidemiology MH - Factor Analysis, Statistical MH - Infant MH - Risk Factors PMC - PMC13413140 OTO - NOTNLM OT - allergic diseases OT - birth cohort OT - dietary patterns OT - factor analysis OT - toddlers COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/07/29 00:35 MHDA- 2026/07/29 18:39 PMCR- 2026/07/22 CRDT- 2026/07/28 20:03 PHST- 2026/07/29 18:39 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 20:03 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.6133/apjcn.202608_35(4).0017 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2026 Aug;35(4):735-748. doi: 10.6133/apjcn.202608_35(4).0017. PMID- 42520924 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261022 IS - 2210-741X (Electronic) IS - 2210-7401 (Linking) VI - 50 IP - 8 DP - 2026 Oct TI - Sarcopenia in decompensated cirrhosis: a comparative analysis of bioelectrical impedance-based measures. PG - 102893 LID - S2210-7401(26)00139-7 [pii] LID - 10.1016/j.clinre.2026.102893 [doi] AB - BACKGROUND: Sarcopenia is highly prevalent in decompensated cirrhosis and strongly associated with adverse clinical outcomes. While bioelectrical impedance analysis (BIA) offers multiple body composition indices, the optimal approach remains uncertain. AIM: To evaluate the prevalence and comparative prognostic performance of Phase Angle (PA) versus other BIA-derived sarcopenia indices in patients with decompensated cirrhosis. METHODS: This prospective observational study included 155 patients with decompensated cirrhosis and ascites who underwent multi-frequency BIA. Sarcopenia was defined using sex-specific cutoffs for PA and four additional BIA-derived indices. Prognostic associations with mortality and infections were assessed through fully adjusted logistic and Cox regression models. RESULTS: Sarcopenia prevalence ranged between 40% and 50% across indices in the primary analysis. Although prevalence estimates were comparable, PA demonstrated superior prognostic performance. Low PA was independently associated with increased 12-month mortality (OR 2.28, 95% CI 1.52-3.42; p < 0.001) and infection risk (OR 1.95, 95% CI 1.32-2.88; p = 0.001), outperforming mass-based indices even after extensive adjustment. Each 1 degrees increase in PA was associated with a 29% reduction in mortality risk (HR 0.71, 95% CI 0.55-0.91; p = 0.008). These associations remained consistent across clinically relevant subgroups, including different ascites severities, Child-Pugh classes, and HCC status. PA also strongly predicted 90-day mortality and hospital readmissions. CONCLUSIONS: In patients with decompensated cirrhosis, PA provides significant added prognostic value beyond traditional BIA-derived muscle mass indices. This readily available bedside parameter may enhance risk stratification and support individualized nutritional and rehabilitative interventions. Its incremental utility warrants further validation in larger multicenter studies. CI - Copyright (c) 2026 Elsevier Masson SAS. All rights reserved. FAU - Elsabaawy, Maha AU - Elsabaawy M AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt; Therapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. Electronic address: maha.ahmed@liver.menofia.edu.eg. FAU - Ragab, Mohammed AU - Ragab M AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. FAU - Al-Khalifa, Maymona AU - Al-Khalifa M AD - Therapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. FAU - Gamil, Khaled AU - Gamil K AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. FAU - Elfayoumy, Marwa AU - Elfayoumy M AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt; Therapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260728 PL - France TA - Clin Res Hepatol Gastroenterol JT - Clinics and research in hepatology and gastroenterology JID - 101553659 SB - IM MH - Humans MH - *Sarcopenia/epidemiology/diagnosis/etiology/complications MH - *Electric Impedance MH - Female MH - *Liver Cirrhosis/complications/mortality MH - Male MH - Prospective Studies MH - Prognosis MH - Middle Aged MH - Prevalence MH - Aged MH - Ascites OTO - NOTNLM OT - Bioelectrical impedance analysis OT - Decompensated cirrhosis OT - Phase angle OT - Prognosis OT - Sarcopenia COIS- Declaration of competing interest The authors have no relevant financial or non-financial interests to disclose. EDAT- 2026/07/29 00:35 MHDA- 2026/10/16 23:33 CRDT- 2026/07/28 19:18 PHST- 2026/02/27 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/10/16 23:33 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 19:18 [entrez] AID - S2210-7401(26)00139-7 [pii] AID - 10.1016/j.clinre.2026.102893 [doi] PST - ppublish SO - Clin Res Hepatol Gastroenterol. 2026 Oct;50(8):102893. doi: 10.1016/j.clinre.2026.102893. Epub 2026 Jul 28. PMID- 42520891 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 11 DP - 2026 Nov TI - Reliability and Validity of a Parent-Reported Diet Quality Screener for Young Children: The Rapid Prime Diet Quality Score for Kids. PG - 156425 LID - S2212-2672(26)00140-1 [pii] LID - 10.1016/j.jand.2026.156425 [doi] AB - BACKGROUND: Pediatric dietary assessment is challenging, particularly for young children who cannot accurately report their own intake. Many existing measures are burdensome for proxy-reporters, and briefer dietary screeners focus on specific dietary components but not total diet quality. OBJECTIVE: The objective of this study was to develop and evaluate the reliability and validity of an adapted brief parent-reported diet quality screener; that is, the rapid Prime Diet Quality Score for Kids (rPDQS-Kids), in relation to food groups and overall diet quality estimated from repeated Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) diet recalls for young children. DESIGN: This was a cross-sectional study that evaluated the psychometric properties of the 16-item rPDQS-Kids. PARTICIPANTS/SETTING: Participants of this study included parents of children aged 1 to 4 years participating in the Special Supplemental Nutrition Program for Women, Infants, and Children (N = 175) in the state of Massachusetts from January 2024 to February 2025. MAIN OUTCOME MEASURES: Information about consumption frequencies was reported by parents using the rPDQS-Kids screener. Mean intake and overall diet quality were also assessed using 2 24-hour recalls. STATISTICAL ANALYSES PERFORMED: Test-retest reliability and internal consistency of the rPDQS-Kids were evaluated. Criterion validity was assessed by comparing the rPDQS-Kids diet quality score with the Healthy Eating Index (HEI) score (HEI-2020 for children aged 2 to 4 years or HEI-Toddlers-2020 for children aged 1 up to 2 years). RESULTS: The rPDQS-Kids showed moderate test-retest reliability (intraclass correlation coefficient for total score 0.69; 95% CI, 0.62 to 0.75). Consistent with a priori hypotheses, internal consistency reliability was low, with ordinal alpha = .27 and ordinal alpha = .34 for the healthy and unhealthy subscores, respectively. Further, a significant correlation was observed between the rPDQS-Kids traffic light diet quality score and HEI-2020 total score among children aged 2 to 4 years (r = 0.32) (P < .001) (n = 127). Among children aged 1 to 2 years (n = 48), rPDQS-Kids was not significantly correlated with the HEI-Toddlers-2020 (P > .05). CONCLUSIONS: The parent-reported rPDQS-Kids shows potential as a low-burden tool for measuring young children's dietary quality. CI - Copyright (c) 2026 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. FAU - Hammad, Nour M AU - Hammad NM AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address: nourhammad@fas.harvard.edu. FAU - Zimmer, Meghan AU - Zimmer M AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Mozaffarian, Rebecca S AU - Mozaffarian RS AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Rimm, Eric B AU - Rimm EB AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. FAU - Kenney, Erica L AU - Kenney EL AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. LA - eng PT - Journal Article PT - Validation Study DEP - 20260728 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - Female MH - Reproducibility of Results MH - Child, Preschool MH - Cross-Sectional Studies MH - Infant MH - Parents MH - Male MH - *Nutrition Assessment MH - *Diet/statistics & numerical data/standards MH - Psychometrics MH - *Diet Surveys/methods/standards MH - Massachusetts MH - *Diet, Healthy/statistics & numerical data MH - Mental Recall OTO - NOTNLM OT - Diet quality OT - Dietary assessment OT - PDQS OT - Preschool-aged children OT - WIC EDAT- 2026/07/29 00:35 MHDA- 2026/10/20 23:28 CRDT- 2026/07/28 19:18 PHST- 2025/05/01 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/10/20 23:28 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 19:18 [entrez] AID - S2212-2672(26)00140-1 [pii] AID - 10.1016/j.jand.2026.156425 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Nov;126(11):156425. doi: 10.1016/j.jand.2026.156425. Epub 2026 Jul 28. PMID- 42520788 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260908 IS - 1476-1645 (Electronic) IS - 0002-9637 (Print) IS - 0002-9637 (Linking) VI - 115 IP - 3 DP - 2026 Sep 2 TI - Social Perceptions of Konzo Disease in Nampula Province, Mozambique. PG - 436-442 LID - 10.4269/ajtmh.26-0017 [doi] AB - Konzo, a neurodegenerative disease prevalent in Nampula Province, Mozambique, presents debilitating symptoms known locally as "mantakassa" ("that which breaks legs"). Although the biomedical literature attributes its cause to insufficiently processed cassava amid food insecurity, traditional narratives often cite supernatural explanations, like witchcraft. This review analyzed the existing literature to understand social perceptions of konzo, focusing on traditional leaders' perspectives and their implications for public health. It found that konzo cases cluster within families owing to shared dietary habits and socioeconomic vulnerabilities, disproportionately affecting women and children. Community narratives often link the disease to spiritual causes, differing from biomedical views. Health care workers noted low diagnostic accuracy and limited knowledge of the condition. Notably, the role of traditional healers, often the first line of care in rural areas, remains underdocumented, highlighting a critical knowledge gap. Further research into their understanding of konzo is essential for developing culturally sensitive health interventions and improving public health strategies. FAU - Raimundo, Litos AU - Raimundo L AD - Faculty of Science and Technology, Fernando Pessoa University, Porto, Portugal. FAU - Rodrigues, Daniela AU - Rodrigues D AD - CIAS-Research Centre for Anthropology and Health-Group of Human Biology, Health and Society, University of Coimbra, Coimbra, Portugal. AD - Department of Life Sciences, University of Coimbra, Coimbra, Portugal. FAU - Silva, Maria-Raquel G AU - Silva MG AD - CIAS-Research Centre for Anthropology and Health-Group of Human Biology, Health and Society, University of Coimbra, Coimbra, Portugal. AD - FP-I3ID and FCS-UFP-Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal. AD - Molecular Oncology and Viral Pathology Group, Research Centre of IPO-Porto (CI-IPOP) & RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO-Porto)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), Porto, Portugal. AD - CHRC-Comprehensive Health Research Centre-Group of Sleep, Chronobiology and Sleep Disorders, Nova Medical School, Nova University of Lisbon, Lisbon, Portugal. AD - RISE-Health, Fernando Pessoa University, Porto, Portugal. LA - eng PT - Journal Article PT - Review DEP - 20260728 PL - United States TA - Am J Trop Med Hyg JT - The American journal of tropical medicine and hygiene JID - 0370507 SB - IM MH - Humans MH - Health Knowledge, Attitudes, Practice MH - Mozambique/epidemiology MH - *Nervous System Diseases/epidemiology/psychology PMC - PMC13417359 COIS- Disclosures: The authors acknowledge the use of artificial intelligence tools, specifically Elicit and Microsoft Copilot, for literature exploration, organization of ideas, and language refinement. All conceptualization, analysis, interpretation, and final editorial decisions remain entirely the responsibility of the authors. The authors declare no conflicts of interest. EDAT- 2026/07/29 00:35 MHDA- 2026/09/03 01:19 PMCR- 2027/07/28 CRDT- 2026/07/28 18:32 PHST- 2026/01/13 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/09/03 01:19 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 18:32 [entrez] PHST- 2027/07/28 00:00 [pmc-release] AID - tpmd260017 [pii] AID - 10.4269/ajtmh.26-0017 [doi] PST - epublish SO - Am J Trop Med Hyg. 2026 Jul 28;115(3):436-442. doi: 10.4269/ajtmh.26-0017. Print 2026 Sep 2. PMID- 42520709 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260806 IS - 1879-1700 (Electronic) IS - 0265-931X (Linking) VI - 298 DP - 2026 Aug TI - Radiological risk assessment due to naturally occurring radionuclides in water and fish from gold mining-impacted regions in northern Tanzania. PG - 108119 LID - S0265-931X(26)00234-1 [pii] LID - 10.1016/j.jenvrad.2026.108119 [doi] AB - Many households in gold-mining regions of northern Tanzania have limited access to safe and reliable drinking water and rely on surface water, groundwater, and locally caught fish as key drinking-water and dietary sources, yet the radiological safety of these sources remains uncertain. This study evaluated age-dependent radiological risks from ingestion of naturally occurring radionuclides ((234)U, (238)U, (226)Ra, (210)Po, (210)Pb) in multiple water sources and in fish tissues (bones, gills and flesh) of African lungfish (Protopterus aethiopicus), Nile tilapia (Oreochromis niloticus) and African Catfish (Clarias gariepinus). Activity concentrations were determined by radiochemical separation followed by alpha spectrometry and gas-flow proportional counting. Annual effective dose (AED) and excess lifetime cancer risk (ELCR) were estimated using age-specific water and fish consumption rates. Groundwater, particularly from shallow wells, produced the highest exposures, with a maximum AED for a 5-year-old child, dominated by (234)U, exceeding both the World Health Organization (WHO) screening level (0.1 mSv/y) and the International Commission on Radiological Protection (ICRP) public dose reference level (1 mSv/y). Fish consumption was the dominant pathway, with African lungfish consistently yielding the highest AEDs, followed by Tilapia and Catfish. The dose contributions were dominated by (210)Pb (75% -96%) and (210)Po (4% - 25%), while (234)U, (238)U, and (226)Ra contributed <1%. The estimated ELCRs associated with consumption of all fish species, exceeded the USEPA acceptable risk range (10(-6) - 10(-4)). Elevated (234)U/(238)U activity ratios (>1) indicated preferential mobilisation of (234)U via alpha-recoil, while low (210)Po/(210)Pb ratios (<1) confirmed (210)Pb predominance. These findings underscore the need for continued radiological monitoring and targeted mitigation to protect vulnerable communities. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Seif, Dorice Rashid AU - Seif DR AD - University of Dar es Salaam, Physics Department, P.O Box 35063, Dar es Salaam, Tanzania; Jozef Stefan Institute, Jamova 39, Ljubljana, SI-1000, Slovenia. FAU - Stiplosek, Leja Rovan AU - Stiplosek LR AD - Jozef Stefan Institute, Jamova 39, Ljubljana, SI-1000, Slovenia. FAU - Kumwenda, Mwingereza John AU - Kumwenda MJ AD - University of Dar es Salaam, Physics Department, P.O Box 35063, Dar es Salaam, Tanzania. FAU - Mazunga, Mohamed AU - Mazunga M AD - University of Dar es Salaam, Physics Department, P.O Box 35063, Dar es Salaam, Tanzania. FAU - Strok, Marko AU - Strok M AD - Jozef Stefan Institute, Jamova 39, Ljubljana, SI-1000, Slovenia. Electronic address: marko.strok@ijs.si. LA - eng PT - Journal Article DEP - 20260728 PL - England TA - J Environ Radioact JT - Journal of environmental radioactivity JID - 8508119 RN - 0 (Water Pollutants, Radioactive) RN - 7440-57-5 (Gold) RN - 4OC371KSTK (Uranium) RN - 0 (Radioisotopes) RN - W90AYD6R3Q (Radium) RN - DQY03U61EJ (Polonium) RN - PJ44V7L07A (Radium-226) SB - IM MH - Animals MH - *Water Pollutants, Radioactive/analysis/metabolism MH - Mining MH - *Radiation Monitoring MH - Risk Assessment MH - *Fishes/metabolism MH - Gold MH - Tanzania MH - Uranium/analysis MH - *Radioisotopes/analysis MH - Radium/analysis MH - Polonium/analysis MH - Background Radiation MH - *Food Contamination, Radioactive/analysis OTO - NOTNLM OT - Age-dependence OT - Drinking water contamination OT - Freshwater fish tissues OT - Gold mining OT - Naturally occurring radionuclides OT - Radiological risk COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/29 00:35 MHDA- 2026/08/07 00:35 CRDT- 2026/07/28 18:09 PHST- 2026/02/23 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/07 00:35 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 18:09 [entrez] AID - S0265-931X(26)00234-1 [pii] AID - 10.1016/j.jenvrad.2026.108119 [doi] PST - ppublish SO - J Environ Radioact. 2026 Aug;298:108119. doi: 10.1016/j.jenvrad.2026.108119. Epub 2026 Jul 28. PMID- 42520436 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260914 IS - 1872-6283 (Electronic) IS - 0379-0738 (Linking) VI - 388 DP - 2026 Nov TI - Diagnostic utility of the drowning index: A review of the literature and analysis of 7105 Danish autopsy cases. PG - 113075 LID - S0379-0738(26)00262-8 [pii] LID - 10.1016/j.forsciint.2026.113075 [doi] AB - BACKGROUND AND AIM: Drowning is a diagnosis of exclusion that relies on circumstantial scene- and autopsy findings. The drowning index (DI) was constructed in previous publications as a suggested aid in the diagnosis of drowning by relating lung weight to spleen weight. This study aimed to evaluate the diagnostic performance of the DI in distinguishing drowning from other causes of death associated with increased lung weight and a group of hanging deaths. METHODS: A retrospective cohort study was conducted using a database of 22,872 Danish autopsy cases, from which 7105 cases of either drowning, cardiac death, poisoning and hanging were selected. DI was calculated for each case. Descriptive statistics and group-wise comparison using Kruskal-Wallis with pairwise Wilcoxon post hoc testing, and receiver operating characteristic (ROC) analysis were performed. A literature review was conducted for comparison. RESULTS: Mean drowning index was significantly higher in drowning (n = 427) cases (15.48) compared with other causes of death (hanging: 8.89, heart failure: 10.24 and poisoning: 10.45). ROC analysis combined with Youden's index identified an optimal DI cut-off of approximately 11, corresponding to a sensitivity of 56% (CI: 51.1-60.7) and a specificity of 67.2% (CI: 66.1-68.4). Findings from the literature review were broadly comparable. CONCLUSION: In this largest study of the DI to date, we propose that the DI is best interpreted as a graded measure of evidential strength for drowning as a cause of death, rather than a dichotomous diagnostic marker. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Jorgensen, Kristian Brochner AU - Jorgensen KB AD - Department of Forensic Medicine, University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100, Denmark. Electronic address: tzs584@alumni.ku.dk. FAU - Busch, Johannes Rodbro AU - Busch JR AD - Department of Forensic Medicine, University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100, Denmark. FAU - Wingren, Carl Johan AU - Wingren CJ AD - Department of Forensic Medicine, University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100, Denmark. LA - eng PT - Journal Article PT - Review DEP - 20260724 PL - Ireland TA - Forensic Sci Int JT - Forensic science international JID - 7902034 SB - IM MH - Humans MH - *Drowning/diagnosis MH - Denmark/epidemiology MH - Retrospective Studies MH - Lung/pathology MH - Spleen/pathology MH - Organ Size MH - Female MH - ROC Curve MH - Male MH - Middle Aged MH - Adult MH - Neck Injuries/mortality/diagnosis/pathology MH - Asphyxia/diagnosis/mortality MH - Sensitivity and Specificity MH - Forensic Pathology MH - Aged MH - Poisoning/diagnosis MH - Adolescent MH - Young Adult MH - Aged, 80 and over OTO - NOTNLM OT - Drowning OT - Drowning index OT - Forensic pathology OT - Postmortem diagnostics COIS- Declaration of Competing Interest The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2026/07/29 00:35 MHDA- 2026/09/09 23:36 CRDT- 2026/07/28 18:04 PHST- 2026/05/28 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/09/09 23:36 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 18:04 [entrez] AID - S0379-0738(26)00262-8 [pii] AID - 10.1016/j.forsciint.2026.113075 [doi] PST - ppublish SO - Forensic Sci Int. 2026 Nov;388:113075. doi: 10.1016/j.forsciint.2026.113075. Epub 2026 Jul 24. PMID- 42519260 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 6 DP - 2026 Jun TI - Admission Respiratory Rate-Oxygenation Index and Outcome of Acute Respiratory Illness in a Pediatric Intensive Care Unit. PG - e111005 LID - 10.7759/cureus.111005 [doi] LID - e111005 AB - Background Acute respiratory illness (ARI) remains a leading cause of pediatric intensive care unit (PICU) admissions and mortality in low- and middle-income countries. Early identification of children at risk of deterioration or ventilatory support is essential to improve outcomes. The Respiratory Rate-Oxygenation (ROX) Index, defined as (peripheral oxygen saturation (SpO(2))/fraction of inspired oxygen (FiO(2)))/respiratory rate, is a non-invasive bedside tool validated in adults with respiratory failure; however, pediatric evidence is scarce. Objectives To evaluate the association of admission ROX Index with (1) mortality and (2) the requirement for positive-pressure ventilation (PPV) among children with ARI admitted to the PICU. Methods A prospective observational study was conducted among 200 consecutively admitted children aged two months to five years with ARI at a tertiary-care hospital. Demographic, anthropometric, and physiological parameters were recorded at admission. The ROX index was computed as (SpO(2)/FiO(2))/respiratory rate. Primary outcomes were in-hospital mortality and need for PPV. Data were analyzed using non-parametric tests and receiver operating characteristic (ROC) analysis; p<0.05 was considered significant (STATA v14; StataCorp LLC, College Station, TX, US). Results The median age was seven months (IQR 4-12); 131 (65.5%) were male patients, and severe undernutrition (weight-for-age Z-score <-3 SD) was observed in 36 (18%) children. Overall mortality was 7% (14/200). The median admission ROX index was lower among non-survivors (5.6 (5.2-6.4)) than survivors (6.3 (5.9-7.1); p=0.002). The ROX index showed moderate discrimination for mortality (AUC=0.746; 95% CI 0.62-0.87) with an optimal cut-off /=60 min/day of MVPA was accumulated on relatively more or fewer valid wear days. Chi-square tests were used to compare ethnic differences in sex, school stage, and activity patterns. Independent-samples t tests were used to compare socioeconomic status, whereas Mann-Whitney U tests were used to compare sleep quality and dietary habit scores. Binary logistic regression was used to examine the associations between insufficient, regular, and weekend warrior patterns and physical health. RESULTS: Compared with the insufficient activity pattern, both the regular activity pattern (OR = 2.193, 95% CI: 1.324-3.633, p = 0.002) and the weekend warrior pattern (OR = 3.278, 95% CI: 1.386-7.749, p = 0.007) were associated with better physical health. No significant difference was observed between the regular and weekend warrior patterns in their associations with physical health (p = 0.417). Among adolescents with an insufficient activity pattern, the likelihood of achieving a physical health score of >/=80 increased gradually with increasing activity intensity, as indicated by the proportion of vigorous physical activity (VPA) and metabolic equivalent (MET) values (p(trend)  < 0.001 and p(trend)  = 0.006, respectively). CONCLUSION: Both regular and weekend warrior patterns were associated with better physical health among adolescents in Tibet. No significant difference was observed between the two patterns, but this finding should be confirmed in future studies with larger weekend warrior samples. Among adolescents with an insufficient activity pattern, activity intensity was also associated with physical health; however, this finding should be interpreted cautiously given the cross-sectional design. CI - Copyright (c) 2026 Yuan, Peng, Song, Liu, Zhang, Zhang and Sun. FAU - Yuan, Meng AU - Yuan M AD - College of Physical Education, Ludong University, Yantai, Shandong, China. AD - Research Center for Adolescent Exercise Promotion and Health, Ludong University, Yantai, Shandong, China. FAU - Peng, Feng AU - Peng F AD - College of Physical Education, Ludong University, Yantai, Shandong, China. AD - Research Center for Adolescent Exercise Promotion and Health, Ludong University, Yantai, Shandong, China. FAU - Song, Bowen AU - Song B AD - College of Physical Education, Ludong University, Yantai, Shandong, China. AD - Research Center for Adolescent Exercise Promotion and Health, Ludong University, Yantai, Shandong, China. FAU - Liu, Chenyu AU - Liu C AD - College of Physical Education, Ludong University, Yantai, Shandong, China. AD - Research Center for Adolescent Exercise Promotion and Health, Ludong University, Yantai, Shandong, China. FAU - Zhang, Xiaotong AU - Zhang X AD - College of Physical Education, Ludong University, Yantai, Shandong, China. AD - Research Center for Adolescent Exercise Promotion and Health, Ludong University, Yantai, Shandong, China. FAU - Zhang, Chen AU - Zhang C AD - College of Physical Education, Ludong University, Yantai, Shandong, China. AD - Research Center for Adolescent Exercise Promotion and Health, Ludong University, Yantai, Shandong, China. FAU - Sun, Yi AU - Sun Y AD - College of Physical Education, Ludong University, Yantai, Shandong, China. AD - Research Center for Adolescent Exercise Promotion and Health, Ludong University, Yantai, Shandong, China. LA - eng PT - Journal Article DEP - 20260706 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Tibetan people RN - Han Chinese people SB - IM MH - Cross-Sectional Studies MH - *Adolescent Behavior/physiology MH - *Exercise/physiology/statistics & numerical data MH - Tibet MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - *Recreation/physiology MH - Time Factors MH - *Adolescent Health/statistics & numerical data MH - East Asian People PMC - PMC13381452 OTO - NOTNLM OT - Tibetan OT - children and adolescents OT - physical activity patterns OT - physical health OT - weekend warriors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/28 18:35 MHDA- 2026/07/29 18:38 PMCR- 2026/07/06 CRDT- 2026/07/28 12:48 PHST- 2026/04/16 00:00 [received] PHST- 2026/06/20 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 18:35 [pubmed] PHST- 2026/07/28 12:48 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1857690 [doi] PST - epublish SO - Front Public Health. 2026 Jul 6;14:1857690. doi: 10.3389/fpubh.2026.1857690. eCollection 2026. PMID- 42518088 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261008 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 93 IP - 10 DP - 2026 Oct TI - Potential Role of Omega-3 Supplementation in Modulating Symptoms and Holter Parameters in Pediatric Inappropriate Sinus Tachycardia. PG - 1040-1045 LID - 10.1007/s12098-026-06306-6 [doi] AB - OBJECTIVES: To evaluate the effect of omega-3 supplementation on heart rate (HR) control and heart rate variability (HRV) in children with inappropriate sinus tachycardia (IST). METHODS: This prospective randomized controlled trial included 60 children (aged 12-16 y) diagnosed with IST. Participants were randomized into two groups: Group A received omega-3 supplementation for 3 mo, while Group B received standard follow-up without treatment. Baseline and post-treatment HR, HRV parameters [Standard deviation of NN intervals (SDNN), Root mean square of successive differences (RMSSD), pNN50], and clinical outcomes were assessed using 24-h Holter monitoring and validated scales. RESULTS: After 3 mo, the omega-3 group showed significant reductions in maximum HR (from 160.5 +/- 17.9 to 142.2 +/- 15.7 bpm, p = 0.000) and average HR (from 98.9 +/- 4.7 to 90.7 +/- 5.5 bpm, p = 0.000). HRV indices also improved significantly: SDNN (p = 0.000), RMSD (p = 0.000), and pNN50 (p = 0.000). In contrast, no significant changes were observed in the control group. Clinical improvement was significantly higher in the omega-3 group (63.3% marked improvement) compared to controls (p <0.001). Obesity (p = 0.049) and pre-hypertension (p <0.001) were associated with poor response to omega-3 therapy. No significant differences in anxiety scores were found between groups. CONCLUSIONS: Omega-3 supplementation significantly improved HR control and HRV in pediatric IST patients. Obesity and elevated blood pressure may limit treatment efficacy. CI - (c) 2026. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - El-Baz, Mohamed Ahmed AU - El-Baz MA AD - Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt. FAU - El Wan, Somaia Abdel Samie AU - El Wan SAS AD - Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt. FAU - Mohamed, Rodina Sobhy AU - Mohamed RS AD - Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt. FAU - Gouda, Eman Khaled AU - Gouda EK AD - Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt. FAU - El-Tabakh, Yousra Mohsen Kamal Ali AU - El-Tabakh YMKA AD - Deparment of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. yousraeltabakh@gmail.com. FAU - Rahman, Eman Gamal Abdul AU - Rahman EGA AD - Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260728 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 RN - 0 (Fatty Acids, Omega-3) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Dietary Supplements MH - Electrocardiography, Ambulatory MH - *Fatty Acids, Omega-3/therapeutic use/administration & dosage MH - Heart Rate/drug effects MH - Prospective Studies MH - *Tachycardia, Sinus/diagnosis/drug therapy/physiopathology MH - Treatment Outcome OTO - NOTNLM OT - Autonomic regulation OT - Heart rate variability OT - Inappropriate sinus tachycardia OT - Omega-3 OT - Pediatrics COIS- Declarations. Conflict of Interest: None. EDAT- 2026/07/28 12:36 MHDA- 2026/10/01 05:30 CRDT- 2026/07/28 11:10 PHST- 2026/03/14 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/10/01 05:30 [medline] PHST- 2026/07/28 12:36 [pubmed] PHST- 2026/07/28 11:10 [entrez] AID - 10.1007/s12098-026-06306-6 [pii] AID - 10.1007/s12098-026-06306-6 [doi] PST - ppublish SO - Indian J Pediatr. 2026 Oct;93(10):1040-1045. doi: 10.1007/s12098-026-06306-6. Epub 2026 Jul 28. PMID- 42517897 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261022 IS - 1432-5233 (Electronic) IS - 0940-5429 (Linking) VI - 63 IP - 10 DP - 2026 Oct TI - The association between adapted dietary index for gut microbiota and carotid intima-media thickness among overweight or obese children and adolescents. PG - 1737-1747 LID - 10.1007/s00592-026-02716-2 [doi] AB - Childhood obesity is associated with early vascular alterations that can be assessed by carotid intima-media thickness (cIMT). The dietary index for gut microbiota (DI-GM) was developed to reflect dietary patterns supportive of microbial diversity, but its use in pediatric populations has not been established. This study investigated the association between an adapted DI-GM (aDI-GM) and cIMT among children and adolescents with overweight or obesity. In this cross-sectional analysis, 354 participants aged 7-18 years were included. Dietary intake was assessed using a validated 147-item food frequency questionnaire, and an adapted 12-component DI-GM was calculated based on available dietary data. Carotid IMT was measured using high-resolution ultrasonography and categorized into tertiles, with the highest tertile defined as high cIMT. Associations were examined using multivariable linear and logistic regression models, adjusted sequentially for demographic, anthropometric, biochemical, lifestyle, and dietary factors. In tertile-based analyses, no statistically significant associations with cIMT were observed. In continuous analyses, higher aDI-GM scores were inversely associated with the odds of high cIMT in the fully adjusted model; specifically, each one-unit increase in aDI-GM was associated with lower odds of high cIMT (OR = 0.79, 95% CI: 0.68-0.92, p < 0.01). These findings differed according to modeling approach and should therefore be interpreted cautiously. Given the cross-sectional design and the exploratory application of an adult-derived index in a pediatric population, these findings should be considered hypothesis-generating and require confirmation in longitudinal studies. CI - (c) 2026. Associazione Medici Diabetologi / Association of Diabetologists (AMD), Societa Italiana di Diabetologia / Italian Society of Diabetology (SID). FAU - Imannezhad, Mobina AU - Imannezhad M AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Nikparast, Ali AU - Nikparast A AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, No 7, Shahid Hafezi Street, Shahid Farahzadi Boulevard, Qods (the West) Town, 1981619573, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Etesami, Elahe AU - Etesami E AD - Department of Nutrition, SR.C., Islamic Azad University, Tehran, Iran. FAU - Asghari, Golaleh AU - Asghari G AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, No 7, Shahid Hafezi Street, Shahid Farahzadi Boulevard, Qods (the West) Town, 1981619573, Tehran, Iran. golaleh.asghari@sbmu.ac.ir. LA - eng PT - Journal Article DEP - 20260728 PL - Germany TA - Acta Diabetol JT - Acta diabetologica JID - 9200299 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Carotid Intima-Media Thickness MH - Female MH - Male MH - Cross-Sectional Studies MH - *Gastrointestinal Microbiome/physiology MH - *Overweight/microbiology MH - *Diet MH - *Pediatric Obesity/microbiology OTO - NOTNLM OT - Carotid intima-media thickness OT - Childhood obesity OT - DI-GM OT - Dietary index for gut microbiota OT - Gut microbiome OT - Subclinical atherosclerosis OT - cIMT COIS- Declarations. Conflict of interest: The authors declare that they have no competing interests. Ethical approval: National nutrition and Food Technology Research Institute (NNFTRI) ethics committee approved the study protocol (IR.SBMU.NNFTRI.REC.1402.015). All participants provided written informed consent and were informed about the study. All procedures performed in studies involving human participants adhered to the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed written consent was obtained from parents or legal guardians, and verbal or written assent was secured from each child or adolescent participant. Consent for publication: Not applicable. EDAT- 2026/07/28 12:36 MHDA- 2026/10/22 23:28 CRDT- 2026/07/28 11:04 PHST- 2025/10/17 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/10/22 23:28 [medline] PHST- 2026/07/28 12:36 [pubmed] PHST- 2026/07/28 11:04 [entrez] AID - 10.1007/s00592-026-02716-2 [pii] AID - 10.1007/s00592-026-02716-2 [doi] PST - ppublish SO - Acta Diabetol. 2026 Oct;63(10):1737-1747. doi: 10.1007/s00592-026-02716-2. Epub 2026 Jul 28. PMID- 42517607 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1545-5017 (Electronic) IS - 1545-5009 (Linking) VI - 73 IP - 9 DP - 2026 Sep TI - Improving Physical Activity Behaviors Among Childhood Cancer Survivors Through an Educational Intervention: A Mixed-Methods Pre-Post Study. PG - e70575 LID - 10.1002/1545-5017.70575 [doi] AB - BACKGROUND: Childhood cancer survivors (CCS) are at increased risk of long-term cardiopulmonary and functional complications, but physical activity participation remains low. Scalable, evidence-based interventions integrated into routine survivorship care are limited, especially in low- and middle-income settings. This study evaluated the effectiveness of a brief, family-centered educational intervention in improving physical activity behaviors and exercise-related cognition among CCS in China. PROCEDURE: We conducted a mixed-methods, single-arm educational intervention involving CCS and their caregivers. Baseline assessments (T0) and follow-up assessments conducted 1-3 months after the intervention (T1) evaluated three major outcome domains: (i) physical activity behaviors, assessed using the Godin Leisure-Time Exercise Questionnaire (GLTEQ) and selected Physical Activity Questionnaire for Children/Adolescents (PAQ-C/A) items, including moderate-to-vigorous physical activity (MVPA) and total physical activity; (ii) exercise-related cognitive constructs, assessed using Health Belief Model (HBM)-based measures and selected Exercise Benefits/Barriers Scale (EBBS) items; and (iii) family support and parental awareness regarding exercise and treatment-related health risks. Semi-structured interviews were conducted to further explore perceptions and experiences related to physical activity participation. RESULTS: A total of 106 CCS completed T0 and 78 (73.6%) completed T1; 18 participated in interviews. At baseline, most survivors reported low physical activity levels and exercise-related fatigue during vigorous activity. Following the intervention, physical activity behaviors improved significantly, with increases in weekly MVPA (from 98.5 to 172.3 min/week; p = 0.004), total physical activity (from 166.6 to 318.0 min/week; p < 0.001), and GLTEQ scores (from 40.4 to 56.0; p = 0.005). Exercise-related cognition also improved, including greater perceived severity of insufficient physical activity, and increased perceived energy and vitality benefits of exercise. Parental awareness of cardiopulmonary risk increased from 50.0% to 71.8% (p = 0.003). Family support behaviors improved, including parental encouragement (p = 0.016), family co-exercise (p = 0.006), and caregivers' own exercise habits (p = 0.008). Qualitative interviews highlighted the importance of medical guidance, family involvement, individualized exercise recommendations, and concerns regarding fatigue and safety. CONCLUSIONS: A brief, family-centered educational intervention was associated with improved physical activity behaviors, enhanced exercise-related cognition, increased parental awareness, and stronger family support among childhood cancer survivors. These findings support the feasibility and potential value of integrating scalable exercise education into routine survivorship care. CI - (c) 2026 Wiley Periodicals LLC. FAU - Cai, Jiaoyang AU - Cai J AD - Hematology & Oncology Follow-up Center, Shanghai Children's Medical Center, National Children's Medical Center, Shanghai Jiao Tong University School of Medicine, and Key Laboratory of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China. AD - Child Health Advocacy Institute, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China. FAU - Cheung, Yin Ting AU - Cheung YT AD - School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. AD - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Zheng, Jiajia AU - Zheng J AD - Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow, China. FAU - Cai, Xiaoman AU - Cai X AD - Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease, Shanghai Children's Medical Center, National Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Pui, Ching-Hon AU - Pui CH AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Hudson, Melissa M AU - Hudson MM AD - Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Zhang, Hao AU - Zhang H AD - Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease, Shanghai Children's Medical Center, National Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. LA - eng GR - St. Jude Children's Research Hospital/ PT - Journal Article DEP - 20260728 PL - United States TA - Pediatr Blood Cancer JT - Pediatric blood & cancer JID - 101186624 SB - IM MH - Humans MH - Male MH - *Exercise MH - Female MH - Child MH - *Cancer Survivors/psychology/education MH - Adolescent MH - *Neoplasms/psychology/rehabilitation MH - Follow-Up Studies MH - Surveys and Questionnaires MH - *Health Behavior MH - Prognosis MH - *Patient Education as Topic/methods MH - Quality of Life MH - Child, Preschool OTO - NOTNLM OT - childhood cancer survivors OT - educational intervention OT - health belief model OT - physical activity OT - survivorship EDAT- 2026/07/28 12:36 MHDA- 2026/08/26 17:37 CRDT- 2026/07/28 08:53 PHST- 2026/05/25 00:00 [revised] PHST- 2026/03/05 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/08/26 17:37 [medline] PHST- 2026/07/28 12:36 [pubmed] PHST- 2026/07/28 08:53 [entrez] AID - 10.1002/1545-5017.70575 [doi] PST - ppublish SO - Pediatr Blood Cancer. 2026 Sep;73(9):e70575. doi: 10.1002/1545-5017.70575. Epub 2026 Jul 28. PMID- 42517327 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260924 IS - 1465-3664 (Electronic) IS - 0142-6338 (Linking) VI - 72 IP - 2 DP - 2026 Feb 9 TI - Task-shifting for lactation support to enhance mother's own milk use in neonatal intensive care unit: a quality improvement initiative. LID - fmag023 [pii] LID - 10.1093/tropej/fmag023 [doi] AB - Mother's own milk improves outcomes for sick and preterm neonates, yet its use in many neonatal intensive care units (NICUs) remains suboptimal. This quality improvement study aimed to increase proportionate consumption of expressed breast milk (EBM) in the NICU and exclusive (EBF) and any breastfeeding (ABF) at discharge by >/=20% above baseline within 12 weeks using sequential Plan-Do-Study-Act (PDSA) cycles and sustain gains thereafter. Root-cause analysis identified poor role clarity in lactation support. In the first implementation phase, neonates receiving <50% EBM were identified during thrice-weekly huddles, and a postgraduate resident provided individual lactation counselling. Although effective, this approach was not sustainable. In the second phase, a nursing orderly was trained as lactation support staff to deliver structured, video-assisted group counselling thrice-weekly. These processes continued through a 1-year sustenance phase. Outcomes were the proportion of EBM volume consumed relative to total milk volume in the NICU and proportions of neonates discharged on EBF and ABF. Balancing measures included feed intolerance, late-onset sepsis, and in-hospital mortality. Data were analysed using p- and u-charts. Proportionate EBM consumption increased from approximately 10% to a sustained 44%-61%. EBF at discharge increased from 21%-23% to 48%-74%, and ABF from 57%-59% to 79%-97%. Staffing gaps during sustenance were addressed through administrative support and inclusion of additional nursing orderlies. All balancing measures showed declining trends. Task-shifting structured, video-assisted group lactation support to trained ancillary staff was feasible and led to sustained gains, offering a practical framework for strengthening lactation support in NICUs with limited human resources. CI - (c) The Author(s) [2026]. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Gupta, Priyanka AU - Gupta P AUID- ORCID: 0000-0003-2280-204X AD - Department of Pediatrics, ESIC Medical College and Hospital, NIT-3, Faridabad 121001, Haryana, India. FAU - Alpna AU - Alpna AD - Department of Pediatrics, ESIC Medical College and Hospital, NIT-3, Faridabad 121001, Haryana, India. FAU - Kapoor, Sanjana AU - Kapoor S AD - Department of Pediatrics, ESIC Medical College and Hospital, NIT-3, Faridabad 121001, Haryana, India. FAU - Narolia, Jodhraj AU - Narolia J AD - Department of Pediatrics, ESIC Medical College and Hospital, NIT-3, Faridabad 121001, Haryana, India. FAU - Raiger, Pawan Kumar AU - Raiger PK AD - Department of Pediatrics, ESIC Medical College and Hospital, NIT-3, Faridabad 121001, Haryana, India. FAU - Dahiya, Renu AU - Dahiya R AD - Department of Pediatrics, ESIC Medical College and Hospital, NIT-3, Faridabad 121001, Haryana, India. FAU - Prakash, Jai AU - Prakash J AD - Department of Pediatrics, ESIC Medical College and Hospital, NIT-3, Faridabad 121001, Haryana, India. LA - eng PT - Journal Article PL - England TA - J Trop Pediatr JT - Journal of tropical pediatrics JID - 8010948 SB - IM MH - Humans MH - *Intensive Care Units, Neonatal MH - Female MH - *Quality Improvement MH - Infant, Newborn MH - *Breast Feeding/statistics & numerical data MH - *Milk, Human MH - *Lactation MH - *Task Shifting MH - *Mothers MH - Infant, Premature MH - Counseling OTO - NOTNLM OT - Breastfeeding OT - Expressed Breast Milk OT - Lactational Support OT - Mother's Own Milk, Task Shifting OT - Quality Improvement Initiative OT - Task Shifting EDAT- 2026/07/28 12:36 MHDA- 2026/07/29 18:38 CRDT- 2026/07/28 06:32 PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 12:36 [pubmed] PHST- 2026/07/28 06:32 [entrez] AID - 8542414 [pii] AID - 10.1093/tropej/fmag023 [doi] PST - ppublish SO - J Trop Pediatr. 2026 Feb 9;72(2):fmag023. doi: 10.1093/tropej/fmag023. PMID- 42516869 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260927 IS - 1520-6394 (Electronic) IS - 1091-4269 (Print) IS - 1091-4269 (Linking) VI - 2026 DP - 2026 TI - Psychosocial Distress Patterns and Their Associations With Deliberate Self-Harm and Suicidality: A Latent Profile Analysis Among Chinese University Students. PG - 4001851 LID - 10.1155/da/4001851 [doi] LID - 4001851 AB - BACKGROUND: Deliberate self-harm (DSH) and suicidality are critical public health concerns among university students, a group facing unique psychosocial stressors. While existing literature has revealed the variable-centered characteristics of psychosocial distress and DSH within this population, a person-centered perspective provides a more nuanced understanding of individual differences, which helps inform the development of targeted interventions. OBJECTIVES: This study aims to identify distinct psychosocial distress profiles among Chinese university students, examine their associations with DSH and suicidality, and explore the sociodemographic factors that influence these profiles. METHODS: A nationwide cross-sectional survey was conducted among 30,992 Chinese university students. Psychosocial distress was assessed using validated scales for loneliness, depressive symptoms, sleep quality, and problematic internet use (PIU). Latent profile analysis (LPA) was employed to identify psychosocial distress profiles. The Bolck-Croon-Hagenaars (BCH) method was applied to compare DSH and suicidality across these profiles, and the R3STEP approach was used to examine sociodemographic correlates of profile membership. RESULTS: Three distinct psychosocial distress profiles were identified: Class 1 (minimal distress profile, 60.08%), Class 2 (moderate distress profile, 34.72%), and Class 3 (severe distress profile, 5.20%). Participants in Class 3 reported significantly higher levels of DSH (M = 7.47) and suicidality (M = 1.98) than those in Class 2 (DSH: M = 2.10, suicidality: M = 0.44) and Class 1 (DSH: M = 0.32, suicidality: M = 0.05) (all p < 0.001). Sociodemographic characteristics, including screen time, exercise duration, enrolled program, romantic relationship status, number of romantic relationships, and sexual experience, differed significantly across profiles (all p < 0.001). CONCLUSION: Based on the selected latent profile solution, approximately 40% of Chinese university students were classified as experiencing elevated psychosocial distress. These profiles were associated with increased levels of DSH and suicidality. Tailored interventions informed by psychosocial distress profiles and sociodemographic characteristics may help improve health management and risk reduction. Given the cross-sectional design, temporal relationships cannot be established, and reverse causation cannot be ruled out. Future longitudinal and interventional studies are needed to validate these findings and facilitate their translation into practice. CI - Copyright (c) 2026 Anqi Xiong et al. Depression and Anxiety published by John Wiley & Sons Ltd. FAU - Xiong, Anqi AU - Xiong A AUID- ORCID: 0009-0000-0207-6808 AD - Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China, scu.edu.cn. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan Province, China, moe.edu.cn. FAU - Huang, Yan AU - Huang Y AD - Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China, scu.edu.cn. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan Province, China, moe.edu.cn. FAU - Yang, Yi AU - Yang Y AD - College of Life Science, Leshan Normal University, Leshan, Sichuan, China, lsnu.edu.cn. FAU - Li, Yuan AU - Li Y AUID- ORCID: 0000-0002-5550-0307 AD - Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China, scu.edu.cn. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan Province, China, moe.edu.cn. FAU - Xiong, Siqi AU - Xiong S AUID- ORCID: 0009-0004-3219-0184 AD - School of Nursing, Chengdu Medical College, Chengdu, China, cmc.edu.cn. FAU - Yu, Yanxing AU - Yu Y AD - Qingdao Medical College, Qingdao University, Qingdao, Shandong, China, qdu.edu.cn. FAU - Luo, Biru AU - Luo B AUID- ORCID: 0000-0002-0323-123X AD - Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China, scu.edu.cn. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan Province, China, moe.edu.cn. FAU - Liao, Shujuan AU - Liao S AUID- ORCID: 0000-0002-9853-9420 AD - Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China, scu.edu.cn. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan Province, China, moe.edu.cn. LA - eng PT - Journal Article DEP - 20260727 PL - United States TA - Depress Anxiety JT - Depression and anxiety JID - 9708816 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology/statistics & numerical data MH - *Self-Injurious Behavior/epidemiology/psychology MH - Young Adult MH - China/epidemiology MH - Universities MH - Cross-Sectional Studies MH - *Psychological Distress MH - Adult MH - Adolescent MH - Latent Class Analysis MH - Loneliness/psychology MH - Depression/epidemiology/psychology MH - *Stress, Psychological/epidemiology/psychology MH - *Suicidal Ideation MH - *Suicide/statistics & numerical data/psychology PMC - PMC13403032 OTO - NOTNLM OT - deliberate self-harm OT - latent profile analysis OT - psychosocial distress OT - suicidality OT - university students COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/27 CRDT- 2026/07/28 04:41 PHST- 2025/04/04 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:41 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - DA4001851 [pii] AID - 10.1155/da/4001851 [doi] PST - epublish SO - Depress Anxiety. 2026 Jul 27;2026:4001851. doi: 10.1155/da/4001851. eCollection 2026. PMID- 42516714 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2753-4294 (Electronic) IS - 2753-4294 (Linking) VI - 4 IP - 3 DP - 2026 TI - Generative AI-enhanced ensemble model for predicting adolescent obesity in India: a school-based study in two southern districts of Karnataka. PG - e004650 LID - 10.1136/bmjph-2025-004650 [doi] LID - e004650 AB - BACKGROUND: Adolescent obesity is a growing concern in India, shaped by sociodemographic, behavioural, familial, sleep and mental health factors. Validated AI-based prediction models for adolescents are scarce. Generative AI (GenAI) offers opportunities to improve accuracy through synthetic data augmentation. METHODS: A case-control, school-based study included 1292 adolescents aged 10-16 years from Mysuru and Chamarajanagar, selected via stratified random sampling. Data on sociodemographic, lifestyle, sleep, mental health, familial and anthropometric measures were collected using validated tools. The dataset was split into training (80%), validation (10%) and testing (10%). Conditional tabular generative adversarial network (CTGAN) generated 1000 synthetic samples and a variational autoencoder (VAE) produced 500, expanding training to 2532 records. Fidelity was assessed using Kolmogorov-Smirnov tests, principal component analysis (PCA), Wasserstein distance and privacy risk checks. A stacking ensemble combining XGBoost, TabNet and TabTransformer with logistic regression stacking was trained using 10-fold cross-validation. RESULTS: The final model achieved an accuracy of 0.977, sensitivity 0.97, specificity 0.985, F1 score 0.97 and AUC 0.994. Calibration was strong (Brier score 0.042; Hosmer-Lemeshow p>0.05). SHAP and TabNet analyses highlighted screen time, sleep duration, parental obesity, physical activity and diet as key predictors. CONCLUSION: The GenAI-enhanced stacking ensemble model accurately predicts adolescent obesity, with strong calibration and interpretability. It identifies behavioural and familial determinants, supporting school and community deployment for early detection and prevention. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. Published by BMJ Group. FAU - Rakshitha, Jayashankar AU - Rakshitha J AUID- ORCID: 0000-0002-2011-1790 AD - Department Of Community Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Sunil Kumar, Doddaiah AU - Sunil Kumar D AUID- ORCID: 0000-0001-8755-3975 AD - Department Of Community Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Santhosh Kumar, M AU - Santhosh Kumar M AD - Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Arun, Vanishri AU - Arun V AD - Department of Information Science and Engineering, JSS Science and Technology University, Mysuru, Karnataka, India. FAU - Krishnamurthy, Kamidi Venkatesh AU - Krishnamurthy KV AUID- ORCID: 0000-0003-4433-8567 AD - Department Of Community Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. LA - eng PT - Journal Article DEP - 20260723 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13405018 OTO - NOTNLM OT - Adolescent OT - Body Mass Index OT - Obesity OT - Risk Assessment COIS- None declared. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/23 CRDT- 2026/07/28 04:39 PHST- 2025/12/02 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:39 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - bmjph-2025-004650 [pii] AID - 10.1136/bmjph-2025-004650 [doi] PST - epublish SO - BMJ Public Health. 2026 Jul 23;4(3):e004650. doi: 10.1136/bmjph-2025-004650. eCollection 2026. PMID- 42516628 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 1016-1430 (Print) IS - 2251-6840 (Electronic) IS - 1016-1430 (Linking) VI - 40 DP - 2026 TI - Online Health Information Needs of Pregnant Women in Low- and Middle-Income Countries: A Systematic Scoping Review. PG - 40 LID - 10.47176/mjiri.40.40 [doi] LID - 40 AB - BACKGROUND: Pregnant women in low- and middle-income countries (LMICs) often face significant barriers in obtaining timely, accurate, and culturally appropriate health information, which can adversely affect pregnancy outcomes, maternal knowledge, and subsequently child health. The purpose of this research is to identify the online health information needs of pregnant women in LMICs. METHODS: This scoping review was conducted to identify the information needs of pregnant women in LMICs. Web of Science, PubMed, Scopus, and Proquest databases were searched to identify related studies. After removing duplicates and screening, studies from a total of retrieved studies were selected for data extraction. Two independent reviewers were involved in screening, selecting, and extracting data, which were synthesized using thematic analysis. All of the studies had good methodological quality. RESULTS: After removing duplicates and screening, 11 qualitative and quantitative studies from a total of 3907 retrieved studies were selected for data extraction. In total, 48 items were identified as online health information needs of pregnant women in LMICs. The information needs of pregnant women were divided into four themes: nutrition, information about the fetus, information about the pregnancy, and maternal health and medication management. CONCLUSION: Pregnant women in LMICs have distinct online health information needs. Despite access to various information sources, there are still gaps in the availability and adequacy of culturally appropriate, reliable, and timely health information tailored to pregnant women's needs in these settings. The importance of improving access to high-quality online health information to support maternal and fetal well-being is evident, suggesting a need for health interventions and policies that address these specific informational gaps to leverage digital platforms effectively. CI - (c) 2026 Iran University of Medical Sciences. FAU - Zarei, Mohammad AU - Zarei M AD - Health Information Technology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Zarea Gavgani, Vahideh AU - Zarea Gavgani V AD - Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Zarei, Atefeh AU - Zarei A AD - Department of Knowledge and Information Science, Islamic Azad University, Hamedan Branch, Hamedan, Iran. FAU - Zare-Farashbandi, Firoozeh AU - Zare-Farashbandi F AUID- ORCID: 0000-0002-1231-642X AD - Health Information Technology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article PT - Review DEP - 20260427 PL - Iran TA - Med J Islam Repub Iran JT - Medical journal of the Islamic Republic of Iran JID - 8910777 PMC - PMC13404397 OTO - NOTNLM OT - Information Needs OT - Information-seeking Behavior OT - Low-income Countries OT - Middle-income Countries OT - Pregnancy OT - Pregnant Women COIS- The authors declare that they have no competing interests. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/04/27 CRDT- 2026/07/28 04:39 PHST- 2025/07/26 00:00 [received] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:39 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - 10.47176/mjiri.40.40 [doi] PST - epublish SO - Med J Islam Repub Iran. 2026 Apr 27;40:40. doi: 10.47176/mjiri.40.40. eCollection 2026. PMID- 42516461 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260927 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 6 DP - 2026 Jun TI - Intimate Partner Violence and Childhood Nutritional Outcomes in Madhya Pradesh: Secondary Analysis of National Family Health Survey-5 (NFHS-5) Data. PG - e111586 LID - 10.7759/cureus.111586 [doi] LID - e111586 AB - BACKGROUND: Intimate partner violence (IPV) and childhood undernutrition represent co-occurring public health challenges in Madhya Pradesh (MP), India. This study examined the association between maternal IPV exposure and child health outcomes, including stunting, wasting, and underweight, using data from the National Family Health Survey-5 (NFHS-5), 2019-21. METHOD: A cross-sectional secondary data analysis was conducted using NFHS-5 Individual Recode and Children's Recode files for MP. The files were merged at the household level, yielding 1,820 mother-child pairs. IPV was assessed using the validated domestic violence (DV) module (n=4,519 women in the 50% subsample). Child outcomes were defined using WHO anthropometric Z-scores. Multivariable binary logistic regression estimated adjusted odds ratios (aOR) with 95% confidence intervals (CIs), adjusting for exogenous sociodemographic confounders, including place of residence, maternal education, wealth index, and maternal age. Demographic and Health Surveys (DHS) sampling weights were applied throughout. RESULTS: IPV prevalence was 28.3% among the DV subsample. Stunting, wasting, and underweight were observed in 36.4%, 18.7%, and 33.4% of children, respectively. After adjustment, IPV was not independently associated with stunting (aOR=1.071, 95% CI: 0.833-1.376, p=0.592), wasting (aOR=0.825, 95% CI: 0.601-1.132, p=0.234), or underweight (aOR=0.912, 95% CI: 0.708-1.174, p=0.475). The household wealth index emerged as the dominant, strongly protective independent predictor across all child health metrics (stunting and underweight: p<0.001; wasting: p=0.017). CONCLUSION: IPV and pediatric malnutrition represent concurrent, intersecting vulnerabilities within MP, but structural poverty is the primary independent predictor of anthropometric failure. Effective policy responses must shift beyond isolated vertical programmes, integrating gender-based violence prevention within maternal and child health platforms alongside robust household economic empowerment. CI - Copyright (c) 2026, Adhikari et al. FAU - Adhikari, Shubhankar AU - Adhikari S AD - Community Medicine, Chirayu Medical College & Hospital, Bhopal, IND. FAU - Mishra, Jaya AU - Mishra J AD - Community Medicine, Chirayu Medical College & Hospital, Bhopal, IND. FAU - Singh, Siddharth AU - Singh S AD - Community Medicine, Chirayu Medical College & Hospital, Bhopal, IND. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13402441 OTO - NOTNLM OT - child nutrition OT - demographic and health survey OT - domestic violence OT - india OT - intimate partner violence OT - nfhs-5 OT - population-based dataset OT - poshan abhiyaan OT - stunting OT - wasting COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/28 06:36 MHDA- 2026/07/28 06:37 PMCR- 2026/06/26 CRDT- 2026/07/28 04:37 PHST- 2026/06/26 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 06:36 [pubmed] PHST- 2026/07/28 04:37 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.7759/cureus.111586 [doi] PST - epublish SO - Cureus. 2026 Jun 26;18(6):e111586. doi: 10.7759/cureus.111586. eCollection 2026 Jun. PMID- 42516430 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2296-4185 (Print) IS - 2296-4185 (Electronic) IS - 2296-4185 (Linking) VI - 14 DP - 2026 TI - Scaling correction in pediatric center-of-pressure analysis: a dual-track computational framework for standardized balance assessment. PG - 1857252 LID - 10.3389/fbioe.2026.1857252 [doi] LID - 1857252 AB - OBJECTIVE: In this study, we developed and validated a standardized computational framework for pediatric balance assessment by integrating anthropometric normalization and a dual-track analytical architecture into a unified center-of-pressure (COP) signal-processing pipeline. METHODS: This study included 90 typically developing children. They were stratified into age groups of 4, 6, and 10 years (n = 30 per group), balanced by sex. The children performed bipedal stance tasks under eyes-open and eyes-closed conditions. Static balance was assessed using a Zebris force platform (120 Hz). COP sway area, mediolateral displacement, and anteroposterior displacement were measured. Two parallel datasets were processed that included raw COP signals and leg length-normalized COP signals. Both datasets were subjected to 2 (sex) x 3 (age) analysis of variance to evaluate scaling sensitivity. Coefficients of variation were computed to assess system-level dispersion. RESULTS: Anthropometric normalization markedly increased parameter sensitivity. Under the eyes-open condition, normalized COP sway area and anteroposterior displacement revealed age effects not detectable in the raw dataset, indicating scaling bias in uncorrected COP signals. The dual-track comparison confirmed that normalization functions as a computational validation component rather than a statistical add-on. For most COP parameters, the coefficients of variation exceeded 50%, indicating substantial interindividual variability consistent with developmental heterogeneity rather than measurement error. CONCLUSION: The proposed framework advances pediatric balance assessment from a descriptive developmental comparison to a standardized, bias-aware signal-processing architecture. By integrating anthropometric scaling correction and dual-track validation into a unified COP signal-processing pipeline, the framework enhances scaling sensitivity, inferential validity, and reproducibility. It is readily deployable within intelligent clinical screening systems and supports the development of age-stratified reference databases and early detection algorithms for pediatric neuromotor assessment. CI - Copyright (c) 2026 Sha, Lin and Chiu. FAU - Sha, Liwa AU - Sha L AD - Department of Sports Training, Jilin Sport University, Changchun, Jilin, China. AD - Department of Education and Learning Technology, National Tsing Hua University, Hsinchu, Taiwan. FAU - Lin, Tzu-Cheng AU - Lin TC AD - Department of Kinesiology, National Tsing Hua University, Hsinchu, Taiwan. FAU - Chiu, Wen Hsin AU - Chiu WH AD - Department of Kinesiology, National Tsing Hua University, Hsinchu, Taiwan. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Front Bioeng Biotechnol JT - Frontiers in bioengineering and biotechnology JID - 101632513 PMC - PMC13402384 OTO - NOTNLM OT - anthropometric normalization OT - center of pressure OT - computational validation OT - dual-track analysis OT - pediatric postural control OT - scaling correction OT - stabilometry COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/13 CRDT- 2026/07/28 04:37 PHST- 2026/04/16 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:37 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - 1857252 [pii] AID - 10.3389/fbioe.2026.1857252 [doi] PST - epublish SO - Front Bioeng Biotechnol. 2026 Jul 13;14:1857252. doi: 10.3389/fbioe.2026.1857252. eCollection 2026. PMID- 42516262 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260921 IS - 1939-795X (Print) IS - 1939-795X (Electronic) IS - 1939-795X (Linking) VI - 19 IP - 2 DP - 2026 TI - Qualities of Effective Nutrition Education Interventions in Athletes: A Systematic Review and Meta-Analysis. PG - 2015 LID - 10.70252/IJES2026215 [doi] LID - 2015 AB - Nutrition knowledge (NK) is consistently reported as low among athletes, potentially limiting optimal dietary intake, performance, recovery, and overall health outcomes. Sports dietitians have a responsibility to provide effective nutrition education and increase NK in athletes. Nutrition education interventions have been shown to improve NK, but practical application standards for designing and conducting nutrition interventions in athletes has yet to be established. The purpose of this meta-analysis is to measure the overall effect of nutrition education interventions on NK in athletes and identify characteristics of nutrition education interventions that effectively increase NK. Seven databases (Academic Search Premier, SPORTDiscus, MEDLINE, ERIC, Health Source: Nursing/Academic Edition, CINAHL Plus with Full Text, and Consumer Health Complete) were searched, yielding 125 studies. Fourteen studies met inclusion criteria and represented 755 athletes (ages 10-32) from various sports. SPSS was utilized to perform the meta-analysis with a random-effects model and DerSimonian-Laird procedure, and effect size (ES) estimates were expressed as Hedges' g. The overall ES of nutrition education intervention on NK was .949 (p < .001, 95% CI [.728, 1.171]), indicating a large statistically significant positive effect. Moderator analyses indicated that study design (Q = 12.577, p < .001), mode of intervention (Q = 17.479, p < .001), length (Q = 12.029, p = .002), and use of validated NK survey (Q = 19.430, p < .001) significantly influenced variation in ES. No significant differences were found for intervention type and participant age. Funnel plot asymmetry suggests potential publication bias, although Egger's test was nonsignificant (p = .897). Findings support the overall effectiveness of nutrition education interventions and provide practical insight into factors that may contribute to their success. FAU - Boyum, Lara AU - Boyum L AD - Department of Nutrition and Hospitality Management, University of Mississippi, Oxford, MS, USA. AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. FAU - Gilmore, Brooke AU - Gilmore B AD - Department of Nutrition and Hospitality Management, University of Mississippi, Oxford, MS, USA. AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. FAU - Franks, Corbit AU - Franks C AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. AD - Department of Health, Exercise Science, & Recreation Management, University of Mississippi, Oxford, MS, USA. AD - Human Movement & High-Performance Lab, University of Mississippi, Oxford, MS, USA. FAU - Kang, Minsoo AU - Kang M AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. AD - Health & Sport Analytics Laboratory, University of Mississippi, Oxford, MS, USA. LA - eng PT - Journal Article PT - Review DEP - 20260601 PL - United States TA - Int J Exerc Sci JT - International journal of exercise science JID - 101513127 PMC - PMC13405668 OTO - NOTNLM OT - Sports nutrition OT - adolescent athlete OT - performance outcomes OT - registered dietitian EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/01 CRDT- 2026/07/28 04:35 PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:35 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - ijes-19-2-15 [pii] AID - 10.70252/IJES2026215 [doi] PST - epublish SO - Int J Exerc Sci. 2026 Jun 1;19(2):2015. doi: 10.70252/IJES2026215. eCollection 2026. PMID- 42516205 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260904 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - How is mental health associated with teenagers' attitudes toward sport participation? - The chain mediating role of exercise self-efficacy and sport confidence. PG - 1892031 LID - 10.3389/fpsyg.2026.1892031 [doi] LID - 1892031 AB - PURPOSE: To elucidate the intrinsic psychological dynamics through which Mental Health is associated with Sport Participation Attitudes in adolescents, this study examines its direct and indirect effects through Exercise Self-Efficacy and Sport Confidence, developing a chained mediation model. METHODS: A stratified cluster sampling method was employed to select 1,384 adolescents aged 12-18 from Hunan Province as research subjects. A validated questionnaire was administered, and data were analyzed using SPSS and the PROCESS macro. RESULTS: Adolescent mental health has a significant positive association with attitudes toward sport participation, and exercise self-efficacy and sport confidence partly explain its effects as mediators. A significant chain mediation path is established between exercise self-efficacy and sport confidence, suggesting that mental health is associated with adolescents' sport participation attitudes through improving exercise self-efficacy and subsequently strengthening sport confidence. CONCLUSION: This study clarifies the hierarchical psychological transmission mechanisms by which mental health is associated with adolescents' sport participation attitudes, and identifies the progressive relationships of cognitive belief variables. These findings provide empirical evidence for adolescent mental health education, the optimization of campus sports teaching, and interventions in sport participation attitudes. CI - Copyright (c) 2026 Qiu, Liu, Zhang, Chen and Huang. FAU - Qiu, Jie AU - Qiu J AD - Hunan Mechanical and Electrical Polytechnic, Changsha, China. FAU - Liu, Mengfen AU - Liu M AD - Hunan Mechanical and Electrical Polytechnic, Changsha, China. FAU - Zhang, Guiyun AU - Zhang G AD - Hunan Mechanical and Electrical Polytechnic, Changsha, China. FAU - Chen, Jiawei AU - Chen J AD - Hunan Mechanical and Electrical Polytechnic, Changsha, China. FAU - Huang, Haoyan AU - Huang H AD - Faculty of Educational Sciences, University of Helsinki, Helsinki, Finland. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 EIN - Front Psychol. 2026 Aug 20;17:1940329. doi: 10.3389/fpsyg.2026.1940329. PMID: 42694509 PMC - PMC13402194 OTO - NOTNLM OT - exercise self-efficacy OT - mental health OT - sport confidence OT - sport participation attitudes OT - teenagers COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/13 CRDT- 2026/07/28 04:34 PHST- 2026/05/26 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:34 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1892031 [doi] PST - epublish SO - Front Psychol. 2026 Jul 13;17:1892031. doi: 10.3389/fpsyg.2026.1892031. eCollection 2026. PMID- 42515816 OWN - NLM STAT- MEDLINE DCOM- 20261003 LR - 20261008 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 10 DP - 2026 Oct 26 TI - Post-COVID-19 rise in central precocious puberty: an integrative Review. PG - 977-989 LID - 10.1515/jpem-2026-0331 [doi] AB - The COVID-19 pandemic was associated with a marked increase in central precocious puberty (CPP), particularly among girls, with pooled estimates showing higher odds during pandemic than pre-pandemic periods. The available evidence supports a reproducible epidemiological signal, but it does not establish a single causal mechanism. This narrative review synthesizes epidemiological findings, clinical features, and proposed mechanisms, including sedentary behavior, weight gain, increased screen exposure, sleep and melatonin rhythm disruption, psychological stress, altered healthcare-seeking behavior, and environmental endocrine-disrupting chemicals (EDCs). Recent high-throughput toxicology data indicate that selected environmental compounds, including musk ambrette and some quaternary ammonium compounds (QACs), can activate human KISS1R- or GnRHR-related signaling in experimental systems. However, pediatric exposure levels, internal dose, target-tissue concentrations, and disease-level causality remain unproven. We therefore frame these chemical findings as a hypothesis-generating exposomic perspective rather than as an established explanation for pandemic-era CPP. A cautious integrative model may help reconcile the strong female predominance, limited mean BMI shift, and temporal association with lockdown-related exposures, while defining testable priorities for future cohort, exposure, and mechanistic studies. CI - (c) 2026 Walter de Gruyter GmbH, Berlin/Boston. FAU - Chen, Xiaoya AU - Chen X AD - Ningbo Ninth Hospital Medical Health Group, Ningbo, China. FAU - Ding, Shuxia AU - Ding S AD - Women and Children's Hospital of Ningbo University, Department of Pediatric Endocrinology, Genetics and Metabolism, Ningbo, China. LA - eng PT - Journal Article PT - Review DEP - 20260729 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 SB - IM MH - Child MH - Female MH - Humans MH - *COVID-19/epidemiology MH - Environmental Exposure/adverse effects MH - Pandemics MH - *Puberty, Precocious/epidemiology/etiology OTO - NOTNLM OT - COVID-19 OT - GnRH OT - KISS1R OT - central precocious puberty OT - endocrine-disrupting chemicals OT - exposome EDAT- 2026/07/28 06:37 MHDA- 2026/10/04 00:32 CRDT- 2026/07/28 01:23 PHST- 2026/05/19 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/10/04 00:32 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:23 [entrez] AID - jpem-2026-0331 [pii] AID - 10.1515/jpem-2026-0331 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 Jul 29;39(10):977-989. doi: 10.1515/jpem-2026-0331. Print 2026 Oct 26. PMID- 42515770 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 1424-8247 (Print) IS - 1424-8247 (Electronic) IS - 1424-8247 (Linking) VI - 19 IP - 7 DP - 2026 Jul 15 TI - Advancing Pediatric Dose Scaling: Strategies, Modeling Approaches, and Clinical Applications. LID - 10.3390/ph19071090 [doi] LID - 1090 AB - Background/Objectives: Selecting appropriate doses for pediatric patients remains one of the most complex challenges in drug development because developmental changes in physiology, metabolism, organ function, and pharmacodynamics substantially influence drug exposure and response. This review summarizes current evidence-based approaches to pediatric dose selection across the developmental continuum and evaluates contemporary model-informed strategies for individualized dosing. Methods: A narrative review of the literature was conducted focusing on pediatric dose-scaling methodologies, developmental pharmacology, physiologically based pharmacokinetic (PBPK) modeling, population pharmacokinetic (PopPK) approaches, exposure-response analysis, therapeutic drug monitoring, and regulatory extrapolation frameworks. Special populations and clinical scenarios relevant to pediatric dose optimization were also evaluated. Results: Simple body weight-based scaling from adult doses inadequately accounts for developmental changes in drug disposition and response. Allometric scaling combined with maturation functions provides improved dose prediction in neonates and infants, while PBPK and PopPK modeling support mechanistic and data-driven dose optimization across pediatric age groups. Fat-free-mass (FFM)-based scaling is preferred over total body weight for many drugs in children with obesity. Additional considerations including obesity, biologics, formulation and excipient safety, pharmacogenomics, critical illness, therapeutic hypothermia, extracorporeal support, therapeutic drug monitoring, and drug-drug interactions substantially influence pediatric dosing strategies. Regulatory frameworks including ICH E11A increasingly support model-informed pediatric extrapolation and precision dosing approaches. Conclusions: Pediatric dose selection has evolved from empirical weight-based dosing toward integrated model-informed strategies incorporating developmental physiology, pharmacometrics, and regulatory science. Allometry, maturation functions, FFM-based scaling, PBPK, PopPK, and therapeutic drug monitoring provide complementary tools for rational pediatric dose optimization, although drug- and pathway-specific validation remains essential, particularly in neonates and critically ill children. FAU - Kudgus Lokken, Rachel A AU - Kudgus Lokken RA AD - Allucent, Cary, NC 27513, USA. FAU - Illamola, Silvia M AU - Illamola SM AD - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. FAU - Job, Kathleen M AU - Job KM AUID- ORCID: 0000-0003-0255-654X AD - Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. FAU - Al-Sallami, Hesham S AU - Al-Sallami HS AUID- ORCID: 0000-0002-0685-327X AD - College of Pharmacy, QU Health, Qatar University, Doha P.O. Box 2713, Qatar. FAU - 't Jong, Geert W AU - 't Jong GW AD - Children's Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 3P4, Canada. FAU - Reith, David M AU - Reith DM AUID- ORCID: 0000-0002-2447-365X AD - Faculty of Medicine, University of Otago, Dunedin 9054, New Zealand. FAU - Birnbaum, Angela K AU - Birnbaum AK AUID- ORCID: 0000-0002-3969-4906 AD - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. AD - Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. AD - Center for Clinical and Cognitive Neuropharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. AD - Department of Medical Laboratory Sciences, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. FAU - Sherwin, Catherine M AU - Sherwin CM AUID- ORCID: 0000-0002-0844-3207 AD - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. AD - Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. AD - Internal Medicine, UWA Medical School, The University of Western Australia, Perth, WA 6009, Australia. AD - Differentia Biotech Ltd., South San Francisco, CA 94080, USA. AD - Department of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, Dayton, OH 45435, USA. LA - eng PT - Journal Article PT - Review DEP - 20260715 PL - Switzerland TA - Pharmaceuticals (Basel) JT - Pharmaceuticals (Basel, Switzerland) JID - 101238453 PMC - PMC13415250 OTO - NOTNLM OT - PBPK modeling OT - allometric scaling OT - dose scaling OT - model-informed drug development (MIDD) OT - neonatal OT - ontogeny OT - pediatric pharmacokinetics OT - pharmacometrics OT - population pharmacokinetics COIS- R.A.K.L. is an employee of Allucent, Cary, NC, USA. C.M.S. is an employee of Differentia Biotech Ltd. but has no stocks, equity, or financial interests in the company. C.M.S. is a Guest Editor for Pharmaceuticals; however, she was not involved in the peer review process or editorial decision-making for this manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/15 CRDT- 2026/07/28 01:23 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/05 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:23 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - ph19071090 [pii] AID - pharmaceuticals-19-01090 [pii] AID - 10.3390/ph19071090 [doi] PST - epublish SO - Pharmaceuticals (Basel). 2026 Jul 15;19(7):1090. doi: 10.3390/ph19071090. PMID- 42514470 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260831 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 22 TI - Does Nutri-Score Reliably Identify High-Sugar Foods Marketed to Children? A Cross-Sectional Study with Implications for Dental Caries Prevention. LID - 10.3390/nu18142401 [doi] LID - 2401 AB - Background/Objectives: Front-of-pack labelling systems such as Nutri-Score are promoted as public health tools to guide consumers towards healthier food choices. However, their capacity to accurately signal sugar content in child-targeted foods-a key determinant of dental caries risk-remains poorly characterised. This study aimed to evaluate whether Nutri-Score category reliably reflects sugar content in pre-packaged foods marketed to children, and to discuss the implications for paediatric oral health. Methods: A cross-sectional observational study analysed the nutritional labels of 100 pre-packaged foods directed at the paediatric population, all displaying a Nutri-Score label, selected from three major supermarket chains in Valencia, Spain. Products were grouped into eight predefined food categories. Sugar content (g/100 g or 100 mL), Nutri-Score category (A-E), and ordinal position of sugar in the ingredients list were recorded. Global association between Nutri-Score grade and sugar content was evaluated using Spearman's rank correlation coefficient; category-level analyses used the Kruskal-Wallis or Mann-Whitney U test as appropriate. Results: A moderate statistically significant positive correlation was found between Nutri-Score grade and sugar content across all 100 products (rho = 0.515, p < 0.001). In the exploratory category-level analyses, suggestive differences were observed in biscuits (H = 8.72, p = 0.033), milks and milk drinks (H = 9.02, p = 0.029), and desserts (H = 8.31, p = 0.016); none of these p-values survived Bonferroni correction for multiple comparisons (adjusted alpha = 0.006). Notably, some products rated A and B contained high sugar levels: one A-rated breakfast cereal reached 22.4 g/100 g, and the highest B-rated product (a flavoured milk drink) contained 22.1 g/100 g. No significant association was detected in cereals, breads, dairy products, juices, or frozen foods. Conclusions: Nutri-Score demonstrated limited discriminatory ability to identify high-sugar child-targeted foods consistently across food categories. These findings support recommending that paediatric dental practitioners advise caregivers to evaluate sugar content and ingredients lists beyond front-of-pack grading. Further regulatory refinement of the algorithm to specifically weight added sugar exposure in child-targeted products may be warranted. FAU - Marques-Martinez, Laura AU - Marques-Martinez L AUID- ORCID: 0000-0001-5722-0547 AD - Dentistry Department, Medicine and Health Science Faculty, Catholic University of Valencia, 46001 Valencia, Spain. AD - Stomatology Department, University of Valencia, 46001 Valencia, Spain. FAU - Perez-Dallal, Carlota Rosa AU - Perez-Dallal CR AD - Dentistry Department, Medicine and Health Science Faculty, Catholic University of Valencia, 46001 Valencia, Spain. FAU - Aura-Tormos, Juan Ignacio AU - Aura-Tormos JI AUID- ORCID: 0000-0002-0054-1005 AD - Stomatology Department, University of Valencia, 46001 Valencia, Spain. FAU - Borrell-Garcia, Carla AU - Borrell-Garcia C AUID- ORCID: 0000-0002-9356-4416 AD - Dentistry Department, Medicine and Health Science Faculty, Catholic University of Valencia, 46001 Valencia, Spain. FAU - Boo-Gordillo, Paula AU - Boo-Gordillo P AUID- ORCID: 0000-0001-9737-716X AD - Dentistry Department, Medicine and Health Science Faculty, Catholic University of Valencia, 46001 Valencia, Spain. AD - Stomatology Department, University of Valencia, 46001 Valencia, Spain. FAU - Carmona-Santamaria, Maria AU - Carmona-Santamaria M AD - Dentistry Department, Medicine and Health Science Faculty, Catholic University of Valencia, 46001 Valencia, Spain. FAU - Guinot-Barona, Clara AU - Guinot-Barona C AUID- ORCID: 0000-0001-8841-7975 AD - Dentistry Department, Medicine and Health Science Faculty, Catholic University of Valencia, 46001 Valencia, Spain. FAU - Garcia-Miralles, Esther AU - Garcia-Miralles E AUID- ORCID: 0000-0001-8864-3702 AD - Stomatology Department, University of Valencia, 46001 Valencia, Spain. LA - eng PT - Journal Article PT - Observational Study DEP - 20260722 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Dietary Sugars) SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Dental Caries/prevention & control MH - *Food Labeling MH - *Nutritive Value MH - *Dietary Sugars/analysis MH - Child MH - Spain PMC - PMC13415646 OTO - NOTNLM OT - Nutri-Score OT - cariogenic potential OT - child-targeted foods OT - dental caries OT - food labelling policy OT - front-of-pack labelling OT - paediatric oral health OT - sugar content COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:36 MHDA- 2026/07/29 18:38 PMCR- 2026/07/22 CRDT- 2026/07/28 01:18 PHST- 2026/07/01 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:36 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - nu18142401 [pii] AID - nutrients-18-02401 [pii] AID - 10.3390/nu18142401 [doi] PST - epublish SO - Nutrients. 2026 Jul 22;18(14):2401. doi: 10.3390/nu18142401. PMID- 42514449 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 21 TI - Estimation of Cardiometabolic Risk in Turkish Adolescents Using Different Anthropometric Techniques: Development and Temporal Validation of a Machine Learning Model. LID - 10.3390/nu18142380 [doi] LID - 2380 AB - BACKGROUND: Although obesity is a recognized cardiometabolic risk determinant, debate persists over the most appropriate anthropometric technique. This study evaluated different anthropometric techniques for predicting cardiometabolic risk in Turkish adolescents and aimed to develop and temporally validate a machine learning-based prediction model, reported in accordance with the TRIPOD statement. METHODS: Adolescents from the Turkiye Nutrition and Health Survey in 2010 (n = 1357) and 2017 (n = 561) were included. Anthropometric and biochemical parameters were assessed. BMI z-scores, waist-to-hip and waist-to-height ratios, triponderal mass index (TMI), visceral adiposity index (VAI), and lipid accumulation product (LAP) were calculated. RESULTS: In ROC analysis, VAI showed the highest discrimination (AUC = 0.747, p < 0.001), followed by LAP (AUC = 0.670). In machine learning, XGBoost achieved the highest training discrimination (ROC-AUC = 0.879), whereas logistic regression was the most stable, with minimal overfitting (DeltaAUC = 0.008). The logistic regression model was well calibrated (Brier score = 0.107; calibration slope 1.00 development, 1.03 external). External temporal validation showed comparable discrimination across models (AUC = 0.742-0.757), with logistic regression showing the greatest consistency. The model showed a high negative predictive value (NPV = 91.7%) and was therefore better suited to ruling out than ruling in cardiometabolic risk; positive findings warrant confirmatory testing (PPV = 35.4%). A simple logistic-based formula was derived. CONCLUSIONS: Machine learning approaches, together with the developed model and simplified formula, may be useful tools for estimating cardiometabolic risk in adolescents and could support a stepwise screening strategy, pending recalibration and prospective validation. FAU - Kahriman, Meryem AU - Kahriman M AUID- ORCID: 0000-0002-6908-7381 AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. FAU - Cakir Bicer, Nihan AU - Cakir Bicer N AUID- ORCID: 0000-0002-7581-9083 AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. AD - Department of Molecular Gastroenterology and Hepatology, Institute of Gastroenterology and Hepatology, Kocaeli University, 41001 Kocaeli, Turkiye. FAU - Bas, Murat AU - Bas M AUID- ORCID: 0000-0002-0494-301X AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260721 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Turkey/epidemiology MH - Adolescent MH - Female MH - Male MH - Predictive Learning Models MH - *Machine Learning MH - *Anthropometry/methods MH - *Cardiometabolic Risk Factors MH - *Cardiovascular Diseases/epidemiology/etiology/diagnosis MH - Body Mass Index MH - Logistic Models MH - Risk Assessment/methods MH - ROC Curve MH - Risk Factors MH - Classification Algorithms PMC - PMC13415240 OTO - NOTNLM OT - body mass index OT - cardiometabolic risk OT - lipid accumulation product index OT - triponderal mass index OT - visceral adiposity index COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/21 CRDT- 2026/07/28 01:18 PHST- 2026/06/23 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - nu18142380 [pii] AID - nutrients-18-02380 [pii] AID - 10.3390/nu18142380 [doi] PST - epublish SO - Nutrients. 2026 Jul 21;18(14):2380. doi: 10.3390/nu18142380. PMID- 42514416 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 17 TI - Metabolomic Profiling of Plasma in Children with Drug-Resistant Epilepsy: The Effect of the Ketogenic Diet on Energy and Amino Acid Pathways. LID - 10.3390/nu18142347 [doi] LID - 2347 AB - BACKGROUND: Drug-resistant epilepsy in children remains a major therapeutic challenge, and the limited efficacy of pharmacological treatment highlights the need for alternative therapeutic approaches, including the ketogenic diet (KD). Although the clinical efficacy of KD is well established, its metabolic effects are not fully understood. This study aimed to characterize the plasma metabolomic profile of children with drug-resistant epilepsy and to explore metabolic differences associated with ketogenic dietary therapy. METHODS: Eighteen children with drug-resistant epilepsy were enrolled, including nine receiving KD and nine receiving a standard diet. Plasma metabolomic profiling was performed using gas chromatography-mass spectrometry (GC-MS). Data were analyzed using multivariate (PCA and OPLS-DA) and univariate statistical approaches. Both variable importance in projection (VIP) scores and metabolic pathway analysis were used to support biological interpretation. RESULTS: A total of 462 annotated GC-MS features were retained after data filtering. OPLS-DA demonstrated clear separation between study groups (R(2)Y = 0.937; Q(2) = 0.594). Eighty-three metabolites had VIP scores > 1, indicating a substantial contribution to the OPLS-DA model, while 22 metabolites differed between groups based on unadjusted p-values. However, only three metabolites remained statistically significant after false discovery rate correction. After false discovery rate correction, beta-hydroxybutyrate and citric acid remained significantly higher in the KD group, whereas 1,4-butanediol was significantly lower. Lower glucose and tryptophan levels were observed only in the unadjusted analyses and should therefore be regarded as exploratory. Similarly, the pathway analysis findings, including those related to amino acid metabolism, were exploratory and require confirmation in larger cohorts. CONCLUSIONS: Ketogenic dietary therapy was associated with distinct changes in the plasma metabolomic profile of children with drug-resistant epilepsy. While the most robust findings involved beta-hydroxybutyrate, citric acid, and 1,4-butanediol, the observed changes in glucose and tryptophan, as well as the amino acid-related pathway findings, should be considered exploratory and require validation in larger independent cohorts before being interpreted as biomarkers or evidence of specific metabolic mechanisms. FAU - Cieslak, Marta AU - Cieslak M AD - Institute of General and Environmental Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Zeromskiego Street, 90-924 Lodz, Poland. FAU - Gatarek, Paulina AU - Gatarek P AUID- ORCID: 0009-0006-3825-522X AD - Institute of General and Environmental Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Zeromskiego Street, 90-924 Lodz, Poland. FAU - Safinski, Piotr AU - Safinski P AD - Department of Developmental Neurology and Epileptology, Research Institute of Polish Mother's Memorial Hospital, 93-338 Lodz, Poland. FAU - Przyslo, Lukasz AU - Przyslo L AUID- ORCID: 0000-0003-0209-4103 AD - Department of Developmental Neurology and Epileptology, Research Institute of Polish Mother's Memorial Hospital, 93-338 Lodz, Poland. FAU - Kaluzna-Czaplinska, Joanna AU - Kaluzna-Czaplinska J AUID- ORCID: 0000-0002-5106-4667 AD - Institute of General and Environmental Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Zeromskiego Street, 90-924 Lodz, Poland. LA - eng PT - Journal Article DEP - 20260717 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Amino Acids) SB - IM MH - Humans MH - *Diet, Ketogenic MH - *Amino Acids/metabolism MH - *Drug Resistant Epilepsy/diet therapy/blood/metabolism MH - Female MH - Child MH - Male MH - *Metabolomics/methods MH - Gas Chromatography-Mass Spectrometry MH - Child, Preschool MH - *Energy Metabolism MH - *Metabolome MH - Adolescent PMC - PMC13415213 OTO - NOTNLM OT - drug-resistant epilepsy OT - gas chromatography-mass spectrometry OT - ketogenic diet OT - plasma metabolome COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/17 CRDT- 2026/07/28 01:18 PHST- 2026/05/18 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - nu18142347 [pii] AID - nutrients-18-02347 [pii] AID - 10.3390/nu18142347 [doi] PST - epublish SO - Nutrients. 2026 Jul 17;18(14):2347. doi: 10.3390/nu18142347. PMID- 42514408 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260831 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 16 TI - Validation of a Nutrition Screening Tool in Critically Ill Children. LID - 10.3390/nu18142340 [doi] LID - 2340 AB - Background/Objectives: Malnutrition is prevalent among patients in the pediatric intensive care unit (PICU) and has been shown to worsen in some patients during the PICU stay. In critically ill children, malnutrition is associated with longer PICU length of stay and increased mortality. Several tools have been developed and validated to screen for nutritional status in children, but none were specifically designed for critically ill children. Our study aims to fill this gap. The goal of this study was to refine and validate a novel PICU nutrition screening tool in a diverse population of critically ill children from six PICUs across the United States. Methods: Subjects underwent the nutrition screen and a Subjective Global Nutritional Assessment (SGNA). We used chi-square tests and Mann-Whitney tests to compare elements of the nutrition screen to the SGNA to identify those elements most associated with malnutrition. We used stepwise logistic regression to determine the best fitting model for a malnutrition screening tool. We proposed a scoring system using the factors identified in the best fitting model to define a positive screen. Results: We enrolled 732 subjects at six PICUs. Of these, 131 subjects (17.9%) were malnourished per the SGNA. Children with and without malnutrition did not differ with respect to age, sex, or race. The likelihood of malnutrition increased as weight-for-age percentile decreased (p < 0.001). We found that the best fitting model of a malnutrition screening tool for critically ill children included weight-for-age percentile, cancer, feeding less, parent perception of growth as poor, and being significantly underweight. We defined a positive screen that should prompt referral to a dietitian. Conclusions: We have developed a nutrition screening tool for critically ill children. FAU - Burneske, Anna AU - Burneske A AUID- ORCID: 0009-0000-9618-266X AD - Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. FAU - Ellenbecker, Collin AU - Ellenbecker C AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Kuhn, Evelyn AU - Kuhn E AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Swoveland, Jacob AU - Swoveland J AUID- ORCID: 0009-0006-8074-7842 AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Oelstrom, Matt AU - Oelstrom M AD - Marshfield Clinic, Marshfield, WI 54449, USA. FAU - Hagen, Scott AU - Hagen S AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Mandli, Sarah AU - Mandli S AUID- ORCID: 0000-0001-8913-4328 AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Sears, Lynne AU - Sears L AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Peterson, Jennifer AU - Peterson J AD - Gundersen Health Systems Hospitals and Clinics, La Crosse, WI 54601, USA. FAU - Pringle, Charlene P AU - Pringle CP AUID- ORCID: 0000-0003-3345-7827 AD - Division of Critical Care, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA. FAU - Sheridan, Kelly AU - Sheridan K AD - Division of Critical Care, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA. FAU - Foxe, Megan AU - Foxe M AD - Division of Critical Care, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. FAU - Hebron, Abigail AU - Hebron A AD - Division of Critical Care, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. FAU - Zivick, Elizabeth AU - Zivick E AUID- ORCID: 0000-0001-9916-7211 AD - Division of Critical Care, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. FAU - Fabus, Nicole AU - Fabus N AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Heisler, Rebecca AU - Heisler R AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Froh, Melissa AU - Froh M AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Shad, Sadaf AU - Shad S AD - Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Mikhailov, Theresa AU - Mikhailov T AUID- ORCID: 0000-0003-1744-9739 AD - Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260716 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Critical Illness MH - Female MH - Child, Preschool MH - *Nutrition Assessment MH - Male MH - Intensive Care Units, Pediatric MH - *Nutritional Status MH - Child MH - Infant MH - *Malnutrition/diagnosis MH - Logistic Models MH - United States MH - *Mass Screening/methods MH - *Child Nutrition Disorders/diagnosis MH - Reproducibility of Results MH - Adolescent PMC - PMC13416380 OTO - NOTNLM OT - clinical nutrition OT - critically ill child OT - enteral nutrition OT - malnutrition OT - nutrition screening tool OT - nutritional support OT - pediatric nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:18 PHST- 2026/05/04 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - nu18142340 [pii] AID - nutrients-18-02340 [pii] AID - 10.3390/nu18142340 [doi] PST - epublish SO - Nutrients. 2026 Jul 16;18(14):2340. doi: 10.3390/nu18142340. PMID- 42514398 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 16 TI - Anaemia Prevention Among Adolescent Girls in Lodhran, Punjab, Pakistan: A School-Based Weekly Iron-Folic Acid Supplementation Pilot Program. LID - 10.3390/nu18142329 [doi] LID - 2329 AB - BACKGROUND/OBJECTIVES: Pakistan has one of the highest burdens of adolescent anaemia in South Asia. A Weekly Iron-Folic Acid Supplementation (WIFAS) program for school-going adolescent girls aged 10-19 years was piloted in the Lodhran District, Punjab, Pakistan. METHODS: A quantitative cross-sectional study was conducted among 750 girls, selected by multi-stage random cluster sampling from 50 public schools across Lodhran; qualitative data were generated through in-depth interviews and focus group discussions with 327 stakeholders. Quantitative data were analyzed using a chi-square test in SPSS. Qualitative data were analyzed in NVIVO using thematic analysis based on the Socio-Ecological Model, enabling environment and institutional systems, community engagement, behavior change and adolescent empowerment and agency. Coding was guided by overarching research questions of acceptability, feasibility and impact. Cases of anaemia averted were estimated using program data and outcome modeling. Qualitative findings were triangulated with quantitative results. RESULTS: The program reached 30,506 girls and was estimated to have averted 5659 cases of anaemia. WIFAS coverage increased from 0% to 100%, with a high level of adherence (80%). Knowledge about anaemia, its signs/symptoms and preventative measures increased significantly at endline. Dietary practices showed positive changes, with significant increase in girls never skipping a meal. Stakeholders attributed success to the creation of an enabling environment through institutional alignment and multisectoral collaboration, culturally adapted, adolescent-friendly materials, and robust community mobilization that proactively addressed socio-cultural barriers. CONCLUSIONS: The school-based WIFAS program for reducing anaemia among adolescent girls was feasible and acceptable in a context where few nutrition services are available to girls. FAU - Kureishy, Sumra AU - Kureishy S AUID- ORCID: 0009-0004-6925-804X AD - Nutrition International, Ottawa, ON K2P 2K3, Canada. FAU - Qureshi, Asim Shahzad AU - Qureshi AS AUID- ORCID: 0009-0002-0425-4107 AD - Nutrition International, Islamabad 44000, Pakistan. FAU - Ambreen, Rakhshinda AU - Ambreen R AUID- ORCID: 0000-0003-2310-1093 AD - Nutrition International, Islamabad 44000, Pakistan. FAU - Raza, Shabina AU - Raza S AUID- ORCID: 0009-0004-4230-8529 AD - Nutrition International, Islamabad 44000, Pakistan. FAU - Roche, Marion L AU - Roche ML AUID- ORCID: 0000-0002-7834-5581 AD - Nutrition International, Ottawa, ON K2P 2K3, Canada. LA - eng GR - ISG1/Global Affairs Canada/ PT - Journal Article DEP - 20260716 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 935E97BOY8 (Folic Acid) RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - Female MH - Pakistan/epidemiology MH - Adolescent MH - *Dietary Supplements MH - Pilot Projects MH - Child MH - Cross-Sectional Studies MH - *Folic Acid/administration & dosage MH - *Iron/administration & dosage MH - Health Knowledge, Attitudes, Practice MH - *School Health Services MH - Young Adult MH - *Anemia/prevention & control/epidemiology MH - Schools MH - *Anemia, Iron-Deficiency/prevention & control/epidemiology PMC - PMC13415225 OTO - NOTNLM OT - adolescent girls OT - anaemia OT - school-based supplementation COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:18 PHST- 2026/04/22 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - nu18142329 [pii] AID - nutrients-18-02329 [pii] AID - 10.3390/nu18142329 [doi] PST - epublish SO - Nutrients. 2026 Jul 16;18(14):2329. doi: 10.3390/nu18142329. PMID- 42514367 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 14 TI - Diagnostic Utility of Simple Inflammatory Markers for Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Syndrome in Children with Obesity. LID - 10.3390/nu18142298 [doi] LID - 2298 AB - Background: Obesity markedly increases the risk of metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD), both of which are characterized by persistent low-grade inflammation. This study aimed to evaluate the diagnostic utility of complete blood count-derived inflammatory markers, including neutrophil-percentage-to-albumin ratio (NPAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), for MASLD and MetS in children with obesity. Methods: Children with obesity aged 7-18 years were prospectively enrolled and underwent anthropometric assessment, laboratory evaluation, and transient elastography with controlled attenuation parameter (CAP) measurement. Participants were classified into MASLD (CAP >/= 250 dB/m) and non-MASLD groups. Children aged >/=10 years were additionally evaluated for MetS according to the International Diabetes Federation criteria. Logistic regression analyses assessed associations between inflammatory markers and MASLD or MetS, while receiver operating characteristic (ROC) analysis evaluated their diagnostic performance. Results: Children with MASLD had significantly higher NLR and lower LMR values than those without MASLD. Higher NLR (OR = 1.946, 95% CI: 1.092-3.467, p = 0.024) and lower LMR (OR = 0.722, 95% CI: 0.539-0.966, p = 0.028) were associated with MASLD, whereas NPAR and PLR were not. After adjustment for age, sex, body mass index and C-reactive protein, both NLR and LMR remained independently associated with MASLD. ROC analysis showed moderate diagnostic performance (AUC = 0.629 for NLR and 0.616 for LMR). None of the evaluated markers were associated with MetS. Conclusions: NLR and LMR were independently associated with MASLD in children with obesity and may represent complementary screening biomarkers for pediatric MASLD. However, given the cross-sectional design and moderate diagnostic performance observed in this study, prospective multicenter studies are needed to validate these findings before clinical implementation. FAU - Zajkowska-Sierpniak, Aleksandra M AU - Zajkowska-Sierpniak AM AUID- ORCID: 0009-0008-0526-3092 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Kwiatek-Sredzinska, Kamila A AU - Kwiatek-Sredzinska KA AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Kowalczuk-Kryston, Monika AU - Kowalczuk-Kryston M AUID- ORCID: 0000-0003-0717-9165 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Anna AU - Lebensztejn A AD - Students' Scientific Association Affiliated with the Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Bobrus-Chociej, Anna AU - Bobrus-Chociej A AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Flisiak-Jackiewicz, Marta AU - Flisiak-Jackiewicz M AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Cudowska, Beata AU - Cudowska B AUID- ORCID: 0000-0002-8062-5865 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Dariusz M AU - Lebensztejn DM AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. LA - eng GR - Grant No: B.SUB.26.423./Medical University of Bialystok/ PT - Journal Article DEP - 20260714 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - *Metabolic Syndrome/diagnosis/blood/etiology/complications MH - Male MH - Female MH - Biomarkers/blood MH - Adolescent MH - *Inflammation/blood MH - Prospective Studies MH - *Pediatric Obesity/complications/blood MH - ROC Curve MH - *Non-alcoholic Fatty Liver Disease/diagnosis/blood MH - *Fatty Liver/diagnosis/blood/etiology MH - Neutrophils MH - Lymphocytes PMC - PMC13414763 OTO - NOTNLM OT - children OT - inflammatory markers OT - metabolic dysfunction-associated steatotic liver disease OT - metabolic syndrome OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/14 CRDT- 2026/07/28 01:18 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - nu18142298 [pii] AID - nutrients-18-02298 [pii] AID - 10.3390/nu18142298 [doi] PST - epublish SO - Nutrients. 2026 Jul 14;18(14):2298. doi: 10.3390/nu18142298. PMID- 42514362 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 13 TI - The EduNutriCRC Questionnaire: A Pilot Knowledge-Attitudes-Practices Study on Nutritional Prevention of Colorectal Cancer in Romanian Adults. LID - 10.3390/nu18142293 [doi] LID - 2293 AB - BACKGROUND/OBJECTIVES: Colorectal cancer (CRC) disproportionately affects Romania, where mortality exceeds the EU average and screening uptake remains low. Diet is among the most modifiable CRC risk factors, yet no validated instrument for assessing nutritional knowledge, attitudes, and practices (KAP) related to CRC prevention exists for the Romanian population. We developed and pilot-tested the EduNutriCRC questionnaire and characterised the corresponding nutritional KAP profile of Romanian adults. METHODS: In a cross-sectional pilot study (April-May 2026), a convenience sample of 301 Romanian adults aged 18-74 years completed the 51-item self-administered questionnaire. The instrument was evaluated for internal consistency and dimensional structure (exploratory factor analysis), with non-parametric tests used for group comparisons. RESULTS: The composite knowledge score (C1-C9; maximum 9) was 6.12 +/- 2.25 with wide item-level variation. Internal consistency was acceptable, and the Attitudes subscale resolved into two factors (Motivation & Self-Efficacy and Perceived Barriers). Screening engagement was critically low (92.4% never tested; 81.7% unaware of the national programme). Although 64.1% expressed willingness to change their diet, 46.2% reported consuming processed meat at least weekly. Motivation & Self-Efficacy, but not the knowledge score, was inversely correlated with risk-food consumption (rho = -0.39, p < 0.001). CONCLUSIONS: EduNutriCRC demonstrated acceptable psychometric properties at the pilot stage. The study identified prevalent nutritional misconceptions, a marked knowledge-behaviour gap, low screening awareness, and a structural mismatch between information sources used and those trusted. Attitudes and self-efficacy, rather than factual knowledge, were the more proximal correlates of dietary behaviour, supporting the development of self-efficacy-focused, culturally adapted educational interventions for CRC prevention in Romania, with EduNutriCRC serving as a baseline and monitoring instrument. FAU - Neamtu, Andreea-Adriana AU - Neamtu AA AUID- ORCID: 0000-0002-5219-5466 AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Department of Pathology, Clinical County Emergency Hospital of Arad, Andrenyi Karoly Str., No. 2-4, 310037 Arad, Romania. AD - Department of Pathology, "Pius Brinzeu" Clinical County Emergency Hospital Timisoara, Liviu Rebreanu Boulevard, No. 156, 300723 Timisoara, Romania. FAU - Anton, Alina AU - Anton A AUID- ORCID: 0000-0002-3818-5261 AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Maghiar, Laura AU - Maghiar L AUID- ORCID: 0000-0001-8901-8271 AD - Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, Universitatii Str., No. 1, 410087 Oradea, Romania. AD - Department of Dermatovenerology, Clinical County Emergency Hospital Bihor, 410169 Oradea, Romania. FAU - Iftode, Andrada AU - Iftode A AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Capraru, Anca-Maria AU - Capraru AM AUID- ORCID: 0009-0001-5908-0231 AD - Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Pharmacy, Poiana Mare Psychiatry Hospital, Garii Str., No. 40, 207470 Poiana Mare, Romania. FAU - Dumitrescu, Cristina AU - Dumitrescu C AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Kis, Andreea-Mihaela AU - Kis AM AUID- ORCID: 0009-0004-4581-8487 AD - Department of Management and Communication in Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Popovici, Ramona Amina AU - Popovici RA AUID- ORCID: 0000-0002-3852-9060 AD - Department of Management and Communication in Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Dehelean, Cristina-Adriana AU - Dehelean CA AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Maghiar, Teodor-Andrei AU - Maghiar TA AD - Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Universitatii Str., No. 1, 410087 Oradea, Romania. AD - Department of Surgery, Pelican Hospital, Corneliu Coposu Str., No. 2, 410450 Oradea, Romania. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adult MH - Middle Aged MH - Romania MH - *Colorectal Neoplasms/prevention & control MH - *Health Knowledge, Attitudes, Practice MH - Female MH - Male MH - Pilot Projects MH - Aged MH - Surveys and Questionnaires MH - Cross-Sectional Studies MH - Adolescent MH - Young Adult MH - *Diet MH - Risk Factors MH - Nutritional Status MH - Feeding Behavior PMC - PMC13414599 OTO - NOTNLM OT - cancer prevention OT - colorectal cancer OT - dietary risk factors OT - health literacy OT - knowledge-attitudes-practices (KAP) OT - nutrition education OT - nutritional prevention OT - pilot validation study OT - questionnaire COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/13 CRDT- 2026/07/28 01:18 PHST- 2026/05/26 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - nu18142293 [pii] AID - nutrients-18-02293 [pii] AID - 10.3390/nu18142293 [doi] PST - epublish SO - Nutrients. 2026 Jul 13;18(14):2293. doi: 10.3390/nu18142293. PMID- 42514356 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 13 TI - Understanding the Gap Between Nutritional Knowledge and Dietary Behavior Among Adolescents with Different BMI Statuses. LID - 10.3390/nu18142287 [doi] LID - 2287 AB - Background/Objectives: The aim of this study was to examine the discrepancy between nutrition-related knowledge (NRK) and nutrition-related practice (NRP) among 1440 Polish school-aged students (10-18 years), according to BMI status, and to identify factors associated with this discrepancy. Methods: This cross-sectional study was conducted via the CAWI method using an author-developed, non-validated questionnaire. Questions assessing NRK and NRP were thematically aligned and referred to the recommendations of the Polish Healthy Eating and Lifestyle Pyramid for Children and Adolescents (aged 4-18 years). Results: Students with excess weight scored significantly lower in nutritional knowledge (NRK: 46%) and practices (NRP: 30%) than those with underweight or normal weight (NRK: 52-53%, NRP: 33-34%). Higher NRK was associated with older age, female sex, larger urban residence (for students with overweight and obesity), and higher maternal/legal guardian education level (for students with normal/underweight body weight). Better NRP was associated with higher NRK and higher physical activity, while rural or small-town living was positively associated with healthier dietary practices and maintenance of normal BMI. Conclusions: The present study confirms that nutritional knowledge is a necessary but insufficient condition for shaping appropriate dietary behaviors among adolescents with different BMI statuses; lifestyle factors, practical food-related skills-including self-assessment of knowledge and adherence to dietary recommendations-and the broader environmental context plays a crucial role. These findings highlight the need for targeted nutrition education programs that expand not only knowledge but also practical skills among students. FAU - Wawrzyniak, Agata AU - Wawrzyniak A AUID- ORCID: 0000-0002-8452-0526 AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 02-787 Warsaw, Poland. FAU - Traczyk, Iwona AU - Traczyk I AUID- ORCID: 0000-0001-7413-1212 AD - The Department of Environmental Hazard Prevention, Allergology and Immunology, Faculty of Health Sciences, Medical University of Warsaw, 02-007 Warsaw, Poland. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Male MH - *Body Mass Index MH - Cross-Sectional Studies MH - Child MH - *Feeding Behavior/psychology MH - Poland MH - *Diet, Healthy MH - Surveys and Questionnaires MH - *Adolescent Behavior MH - Nutritional Status MH - Overweight MH - Life Style PMC - PMC13415248 OTO - NOTNLM OT - adolescents OT - body mass index (BMI) OT - food literacy OT - nutrition literacy OT - nutrition-related knowledge (NRK) OT - nutrition-related practice (NRP) OT - physical activity OT - socio-demographic factors COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/13 CRDT- 2026/07/28 01:18 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - nu18142287 [pii] AID - nutrients-18-02287 [pii] AID - 10.3390/nu18142287 [doi] PST - epublish SO - Nutrients. 2026 Jul 13;18(14):2287. doi: 10.3390/nu18142287. PMID- 42514354 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260825 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 13 TI - Non-HDL Cholesterol as a Practical Gatekeeper for Adolescent Dyslipidemia Screening: Implications for Nutrition and Public Health. LID - 10.3390/nu18142285 [doi] LID - 2285 AB - Dyslipidemia in adolescents represents an early and potentially modifiable stage in the lifelong trajectory of cardiovascular disease. However, optimal lipid screening strategies in this age group remain controversial, particularly regarding feasibility, biological relevance, and reliance on family history. Non-high-density lipoprotein cholesterol (non-HDL cholesterol) has emerged as a promising screening marker because it reflects the total burden of atherogenic lipoproteins and can be reliably assessed even without fasting, making it particularly suitable for large-scale pediatric screening settings. A recent nationwide population-based study of Korean adolescents provides robust real-world evidence supporting the utility of non-HDL cholesterol in dyslipidemia screening, across both sexes and independent of familial lipid risk. From a nutritional and public health perspective, non-HDL cholesterol is closely related to dietary habits, postprandial hyperlipidemia, and metabolic stress, and is particularly important in the modern food environment characterized by increased consumption of ultra-processed foods. This Opinion discusses the biological rationale, clinical feasibility, and population-level implications of non-HDL cholesterol-based screening in adolescents. By linking lipid biology with nutrition-focused prevention and lifelong cardiovascular health, non-HDL cholesterol may serve as a practical gatekeeper for early risk identification and upstream intervention. FAU - Nakamura, Kazufumi AU - Nakamura K AUID- ORCID: 0000-0001-8845-3626 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Okada, Taiji AU - Okada T AUID- ORCID: 0000-0002-8878-3446 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Watanabe, Nobuhide AU - Watanabe N AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Sato, Hirotomo AU - Sato H AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Kagawa, Yuzo AU - Kagawa Y AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Kawahara, Hiroshi AU - Kawahara H AUID- ORCID: 0000-0002-0615-4129 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Sakamoto, Takahiro AU - Sakamoto T AUID- ORCID: 0000-0001-8846-1239 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Yamasaki, Seita AU - Yamasaki S AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Tanabe, Junya AU - Tanabe J AUID- ORCID: 0000-0001-8263-6077 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Furuta, Madoka AU - Furuta M AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Kawanami, Yuka AU - Kawanami Y AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Miki, Yuko AU - Miki Y AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Endo, Akihiro AU - Endo A AUID- ORCID: 0000-0002-7161-5323 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 97C5T2UQ7J (Cholesterol) RN - 0 (Cholesterol, HDL) SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Biomarkers/blood MH - *Cholesterol/blood MH - Cholesterol, HDL/blood MH - *Dyslipidemias/diagnosis/blood MH - *Mass Screening/methods MH - Nutritional Status MH - *Public Health MH - Risk Factors PMC - PMC13414525 OTO - NOTNLM OT - adolescent OT - dyslipidemia OT - non-HDL cholesterol COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/13 CRDT- 2026/07/28 01:18 PHST- 2026/06/16 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - nu18142285 [pii] AID - nutrients-18-02285 [pii] AID - 10.3390/nu18142285 [doi] PST - epublish SO - Nutrients. 2026 Jul 13;18(14):2285. doi: 10.3390/nu18142285. PMID- 42514328 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 10 TI - Sub-Optimal Nutritional Knowledge and Dietary Intake in Gaelic Team Sport Athletes: Limited Associations Between Knowledge and Dietary Adequacy. LID - 10.3390/nu18142259 [doi] LID - 2259 AB - Background/Objectives: To assess the nutritional knowledge and dietary intake of Gaelic team sport athletes and investigate any association between nutrition knowledge and dietary intake. Methods: Male/female athletes competing in Gaelic football, hurling and camogie, aged 18-40 years and training/competing at least twice weekly, were recruited. Nutrition knowledge was assessed using the validated Nutrition for Sport Knowledge Questionnaire (NSKQ). Dietary intake was assessed using a 4-day semi-quantitative food diary. Results: In total, 354 players (male n = 215, female n = 139; elite n = 133, sub-elite n = 221) completed the NSKQ; 53.1% had "poor" knowledge (score 0.70), although several scales showed lower reliability estimates. Results: Adolescents diagnosed with eating disorders showed significantly higher levels of problematic eating behaviours (rg = 0.94), exercise fixation (rg = 0.71), exercise commitment (rg = 0.33), withdrawal symptoms (rg = 0.52), exercise for weight control (rg = 0.83), and insight into problems (rg = 0.77) than athletes. In contrast, athletes reported higher levels of exercise for social (rg = 0.74) and health-related reasons (rg = 0.40). Effect sizes ranged from moderate to very large. These findings indicate marked differences in the psychological motives and compulsive characteristics of exercise between adolescents with eating disorders and athletes. Conclusions: This pilot study suggests that adolescents with eating disorders differ from athletes primarily in the psychological characteristics and motives underlying exercise rather than in exercise volume alone. These findings may help inform the assessment of problematic exercise in clinical practice, although they require confirmation in larger, adequately controlled studies. FAU - Jaroch-Lidzbarska, Magdalena AU - Jaroch-Lidzbarska M AUID- ORCID: 0000-0002-5355-8716 AD - Department of Physical Culture, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1, 80-336 Gdansk, Poland. FAU - Hryniewicz, Konrad AU - Hryniewicz K AD - Department of Marketing and Quantitative Methods, Faculty of Management and Quality Science, Gdynia Maritime University, Morska 81/87, 81-225 Gdynia, Poland. FAU - Sawicki, Piotr AU - Sawicki P AD - Department of Physical Culture, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1, 80-336 Gdansk, Poland. FAU - Wilczynska, Dominika AU - Wilczynska D AD - Faculty of Social and Humanities, WSB Merito University, Grunwaldzka 238A, 80-266 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260712 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13412378 OTO - NOTNLM OT - adolescents OT - athletes OT - eating disorders OT - obligatory exercise OT - psychiatric patients COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/12 CRDT- 2026/07/28 01:14 PHST- 2026/05/24 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:14 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - jcm15145455 [pii] AID - jcm-15-05455 [pii] AID - 10.3390/jcm15145455 [doi] PST - epublish SO - J Clin Med. 2026 Jul 12;15(14):5455. doi: 10.3390/jcm15145455. PMID- 42512745 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 14 DP - 2026 Jul 22 TI - Validation of the Revised Version of the Social Cognitive Theory-Based Scale for Factors Influencing Eating Behavior in Adolescents. LID - 10.3390/healthcare14142229 [doi] LID - 2229 AB - Background/Objectives: Social Cognitive Theory (SCT) constructs are associated with adolescents' eating habits. Validated surveys are needed to assess these constructs (in different populations and languages), considering both personal and socio-environmental factors, including peer influence. Therefore, the objective of this study was to validate the SCT-based Scale for Factors Influencing Eating Behavior in Adolescents (SCT-FIEBA), in Spanish. Methods: The scale was administered to 705 high school students from two schools in the Guadalajara Metropolitan Area, Mexico, with randomized and stratified selection. Two weeks later, 43 participants completed the retest. Construct validity was assessed using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA); internal consistency was assessed using Cronbach's alpha and McDonald's omega; and temporal stability was assessed using the Intraclass Correlation Coefficient (ICC), with 95% confidence intervals (CIs). Additionally, factor patterns influencing eating behavior were identified using hierarchical cluster analysis and discriminant analysis. Results: EFA (n = 353) showed an adequate structure with seven or eight factors (with 34 items). However, CFA (n = 352) showed a better fit with eight factors and 33 items (RMSEA = 0.073, SRMR = 0.083, CFI = 0.91, TLI = 0.90) than the other models. The scale's internal consistency was excellent (Cronbach's alpha = 0.92, CI 0.92-0.93; McDonald's omega = 0.93, CI 0.92-0.93), with all sections scoring from moderate to excellent. The reproducibility indices were good for the whole scale (ICC = 0.70, CI 0.50-0.82) and four sections; the other four presented moderate values. It is recommended to verify reproducibility in a larger sample. Hierarchical cluster analysis yielded better results with four patterns influencing eating behavior based on SCT, and the discriminant analysis results were satisfactory (Wilks' lambda = 0.108; 87% of cases correctly classified). Conclusions: The SCT-FIEBA demonstrated validity and reliability for assessing SCT constructs applied to eating behavior among high school adolescents in a Mexican population, as well as for identifying four distinct psychosocial patterns that influence eating behavior. FAU - Flores-Vazquez, Ana Silvia AU - Flores-Vazquez AS AUID- ORCID: 0000-0002-2268-9959 AD - Departamento de Alimentacion y Nutricion, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. FAU - Rodriguez-Rocha, Norma Patricia AU - Rodriguez-Rocha NP AUID- ORCID: 0000-0001-5800-3130 AD - Departamento de Alimentacion y Nutricion, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. AD - Instituto Regional de Investigacion en Salud Publica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. FAU - Franco-Paredes, Karina AU - Franco-Paredes K AUID- ORCID: 0000-0002-5899-3071 AD - Departamento de Promocion, Preservacion y Desarrollo de la Salud, Centro Universitario del Sur, Universidad de Guadalajara, Avenida Enrique Arreola Silva 883, Centro, Ciudad Guzman 49000, Jalisco, Mexico. FAU - Macedo-Ojeda, Gabriela AU - Macedo-Ojeda G AUID- ORCID: 0000-0002-3815-2160 AD - Departamento de Alimentacion y Nutricion, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. AD - Instituto de Investigacion en Ciencias Biomedicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. LA - eng GR - 661992/National Council for Humanities, Sciences, and Technologies (CONAHCYT)/ PT - Journal Article DEP - 20260722 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13411829 OTO - NOTNLM OT - adolescents OT - nutrition OT - reliability OT - scale OT - social cognitive theory OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/22 CRDT- 2026/07/28 01:12 PHST- 2026/05/14 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:12 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - healthcare14142229 [pii] AID - healthcare-14-02229 [pii] AID - 10.3390/healthcare14142229 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jul 22;14(14):2229. doi: 10.3390/healthcare14142229. PMID- 42512730 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 14 DP - 2026 Jul 21 TI - Caregivers' Attitudes Toward Baby-Led Weaning: Development and Psychometric Validation of the BLW-CAS. LID - 10.3390/healthcare14142214 [doi] LID - 2214 AB - Background/Objectives: Baby-Led Weaning (BLW) is an increasingly adopted complementary feeding approach in which infants self-feed family foods rather than being spoon-fed purees. Caregivers' attitudes play a central role in its adoption and implementation, yet no validated instrument has been specifically designed to assess caregivers' attitudes toward BLW. This study aimed to develop and psychometrically validate the BLW Caregiver Attitudes Scale (BLW-CAS). Methods: A methodological psychometric study was conducted in two phases. Scale development involved a literature review, expert panel evaluation, and cognitive pretesting with caregivers. Psychometric validation was conducted among 256 caregivers, while temporal stability was assessed in an independent test-retest sample of 92 caregivers. Content validity, internal consistency, temporal stability, construct validity, and convergent validity were examined using established psychometric methods. Results: The final 16-item BLW-CAS comprised three dimensions: Predisposition, Self-efficacy, and Practical Skills. The revised scale achieved an S-CVI/Ave of 0.93. The three-factor exploratory solution accounted for 67.46% of the total item variance. The three-factor CFA model showed good overall fit (CFI = 0.995; TLI = 0.994; RMSEA = 0.052; SRMR = 0.066). Internal consistency was acceptable to excellent across subscales (alpha = 0.757-0.913; omega = 0.807-0.953), and test-retest reliability was good (ICC = 0.832). Positive small-to-moderate correlations with general self-efficacy (r = 0.298) and decision satisfaction (r = 0.350) supported convergent validity. Conclusions: The Spanish BLW-CAS is a concise, multidimensional instrument with promising psychometric properties for assessing caregivers' attitudes toward BLW, supporting future research and the evaluation of interventions related to complementary feeding practices. FAU - Marquez-Diaz, Rita Rocio AU - Marquez-Diaz RR AUID- ORCID: 0000-0003-4842-3208 AD - Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain. FAU - Ruiz-Fernandez, Maria Dolores AU - Ruiz-Fernandez MD AUID- ORCID: 0000-0002-6454-4723 AD - Department of Nursing Science, Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain. AD - Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Ventura-Miranda, Maria Isabel AU - Ventura-Miranda MI AUID- ORCID: 0000-0001-8949-5772 AD - Department of Nursing Science, Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain. FAU - Fernandez-Medina, Isabel Maria AU - Fernandez-Medina IM AUID- ORCID: 0000-0003-0805-1542 AD - Department of Nursing Science, Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain. LA - eng PT - Journal Article DEP - 20260721 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13409823 OTO - NOTNLM OT - attitudes OT - baby-led weaning OT - caregivers OT - complementary feeding OT - psychometrics OT - scale development COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:36 MHDA- 2026/07/28 06:37 PMCR- 2026/07/21 CRDT- 2026/07/28 01:12 PHST- 2026/05/08 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 06:36 [pubmed] PHST- 2026/07/28 01:12 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - healthcare14142214 [pii] AID - healthcare-14-02214 [pii] AID - 10.3390/healthcare14142214 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jul 21;14(14):2214. doi: 10.3390/healthcare14142214. PMID- 42512724 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 14 DP - 2026 Jul 21 TI - High-Flow Nasal Oxygen in Contemporary Airway Management: Enhancing Physiological Safety in Anaesthesia-A Narrative Review. LID - 10.3390/healthcare14142206 [doi] LID - 2206 AB - High-flow nasal oxygen (HFNO) has become an increasingly important component of contemporary airway management, extending beyond its origins as a therapy for hypoxaemic respiratory failure to a versatile perioperative tool used across operating theatres, non-operating-room anaesthesia (NORA), and critical care settings. By delivering heated, humidified oxygen at high flow rates, HFNO provides a range of physiological benefits including reliable oxygen delivery, anatomical dead-space washout, low-level positive airway pressure, and facilitation of apnoeic oxygenation. This narrative review explores the physiological mechanisms underpinning HFNO and examines its evolving role in modern anaesthetic practice. The evidence supporting its use for preoxygenation, apnoeic oxygenation, postoperative respiratory support, procedural sedation, tubeless airway surgery, and management of the physiologically difficult airway is reviewed. Particular attention is given to high-risk populations, including patients living with obesity, obstetric patients, and children, as well as applications in a range of NORA environments. The review also examines key limitations and safety considerations, including hypercapnia, aspiration risk, airway obstruction, airway-fire hazards, human factors, and emerging concerns regarding environmental sustainability. While HFNO can improve oxygenation and increase the margin of safety during periods of physiological vulnerability, it should not be viewed as a substitute for definitive airway management or vigilant monitoring. HFNO represents a significant advance in physiology-centred airway management. Its greatest value lies not in routine application, but in thoughtful integration into broader airway safety strategies where meaningful physiological or patient-centred benefit is anticipated. FAU - Bradley, William P L AU - Bradley WPL AUID- ORCID: 0000-0002-8711-4590 AD - Department of Anaesthesiology and Perioperative Medicine, The Alfred, Melbourne, VIC 3004, Australia. AD - School of Translational Medicine, Faculty of Medicine Nursing and Allied Health, Monash University, Melbourne, VIC 3004, Australia. FAU - Anderson, Jane AU - Anderson J AD - Department of Anaesthesia and Pain Medicine, Epworth Healthcare, Melbourne, VIC 3121, Australia. AD - Department of Critical Care, The University of Melbourne, Melbourne, VIC 3010, Australia. FAU - Balkin, Maryanne AU - Balkin M AD - Department of Anaesthesiology and Perioperative Medicine, The Alfred, Melbourne, VIC 3004, Australia. AD - School of Translational Medicine, Faculty of Medicine Nursing and Allied Health, Monash University, Melbourne, VIC 3004, Australia. FAU - Brewster, David J AU - Brewster DJ AUID- ORCID: 0000-0002-0710-1889 AD - School of Translational Medicine, Faculty of Medicine Nursing and Allied Health, Monash University, Melbourne, VIC 3004, Australia. AD - Intensive Care Unit, Cabrini Hospital, Melbourne, VIC 3144, Australia. FAU - Kayak, Eugenie AU - Kayak E AUID- ORCID: 0000-0003-1462-8838 AD - Department of Anaesthesiology and Perioperative Medicine, The Alfred, Melbourne, VIC 3004, Australia. AD - Department of Critical Care, The University of Melbourne, Melbourne, VIC 3010, Australia. AD - Department of Anaesthesia, Austin Health, Melbourne, VIC 3084, Australia. FAU - Shariffuddin, Ina I AU - Shariffuddin II AUID- ORCID: 0000-0002-7528-9027 AD - Department of Anaesthesiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia. AD - Medical Education & Research Development Unit, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia. FAU - Tan, Patrick C F AU - Tan PCF AUID- ORCID: 0000-0002-1699-771X AD - Department of Critical Care, The University of Melbourne, Melbourne, VIC 3010, Australia. AD - Department of Anaesthesia, The Royal Women's Hospital, Melbourne, VIC 3052, Australia. FAU - Wong, Patrick AU - Wong P AUID- ORCID: 0000-0002-8263-8248 AD - Department of Anaesthesia and Pain Medicine, Waikato Hospital, Hamilton 3204, New Zealand. LA - eng PT - Journal Article PT - Review DEP - 20260721 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13409782 OTO - NOTNLM OT - apnoeic oxygenation OT - high-flow nasal oxygen OT - respiratory physiology COIS- WB has received a travel sponsorship from Endomed in Thailand for the AACA 2026 conference. He is a past Chair of ANZCA Airway Management SIG and was the chair of the working party for ANZCA Professional Guidance on HFNO and fires. JA has no conflicts of interest. MB is on the executive committee of ANZCA Airway Management SIG. DB is on the Safe Airway Society Clinical Council. EK has no conflicts of interest. IS is a past President of the Malaysian Society of Anaesthesiologists and past President of the Malaysian Society of Paediatric Anaesthesia. PT has received Fisher & Paykel Healthcare equipment for research. PW was on the working party for ANZCA Professional Guidance on HFNO and fires. EDAT- 2026/07/28 06:36 MHDA- 2026/07/28 06:37 PMCR- 2026/07/21 CRDT- 2026/07/28 01:12 PHST- 2026/06/04 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/12 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 06:36 [pubmed] PHST- 2026/07/28 01:12 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - healthcare14142206 [pii] AID - healthcare-14-02206 [pii] AID - 10.3390/healthcare14142206 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jul 21;14(14):2206. doi: 10.3390/healthcare14142206. PMID- 42512699 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 14 DP - 2026 Jul 20 TI - Exploring the Association Between Psychological Inflexibility, Experiential Avoidance and Sleep-Related Problems Among Adolescents: The EHDLA Study. LID - 10.3390/healthcare14142183 [doi] LID - 2183 AB - Background: Adolescence is a sensitive period during which sleep undergoes substantial change, increasing vulnerability to sleep disturbances and their health consequences. Psychological inflexibility (PI) and experiential avoidance (EA), operationalized through the Acceptance and Action Questionnaire-II (AAQ-II), have been associated with poorer sleep among adults; however, evidence in adolescents remains scarce. This study examined the association between PI, EA, and sleep-related problems in a representative sample of Spanish adolescents. Methods: A cross-sectional analysis was conducted using data from 623 adolescents (aged 12-17 years; 56.7% girls) from the Eating Healthy and Daily Life Activities (EHDLA) study, conducted in the Valle de Ricote (Murcia, Spain) during 2021-2022. PI and EA were assessed with the Spanish-validated AAQ-II; sleep-related problems were screened using the BEARS (B = Bedtime problems, E = Excessive daytime sleepiness, A = Awakenings during the night, R = Regularity and duration of sleep, S = Snoring) questionnaire across five domains. Generalized linear models were adjusted for sex, age, socioeconomic status, physical activity, sedentary behavior, body mass index (BMI) z-score, energy intake, and sleep duration. Results: Higher AAQ-II scores were significantly associated with increased probabilities of bedtime problems (+0.9% per point; 95% confidence interval [CI]: 0.6-1.1%), excessive daytime sleepiness (+1.0%; 95% CI: 0.7-1.2%), nocturnal awakenings (+0.7%; 95% CI: 0.5-1.0%), and problems with sleep regularity and duration (+0.8%; 95% CI: 0.5-1.1%). Each additional AAQ-II point increased the probability of reporting any sleep-related problem by 1.2% (95% CI: 0.9-1.5%; p < 0.001). Corresponding adjusted odds ratios ranged from 1.04 to 1.06 per point. No significant association was found for snoring. Conclusions: In this cross-sectional study, psychological inflexibility and experiential avoidance were positively associated with several sleep-related problems among adolescents. Longitudinal and intervention studies are warranted before causal or clinical recommendations can be made. FAU - Zalamea-Delgado, Maria Paula AU - Zalamea-Delgado MP AUID- ORCID: 0009-0004-2607-2907 AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Guayaquil 0901952, Ecuador. FAU - Jimenez-Lopez, Estela AU - Jimenez-Lopez E AUID- ORCID: 0000-0001-8553-7701 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain. AD - Centro de Investigacion Biomedica en Red de Salud Mental, Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Mesas, Arthur Eumann AU - Mesas AE AUID- ORCID: 0000-0002-0088-8607 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty Education and Social Sciences, Universidad Andres Bello, Vina del Mar 2520000, Chile. FAU - Gutierrez-Espinoza, Hector AU - Gutierrez-Espinoza H AUID- ORCID: 0000-0002-4650-3426 AD - Faculty of Education, Universidad Autonoma de Chile, Santiago 7500138, Chile. FAU - Olivares-Arancibia, Jorge AU - Olivares-Arancibia J AUID- ORCID: 0000-0002-7186-3941 AD - AFySE Group, Research in Physical Activity and School Health, School of Physical Education, Faculty of Education, Universidad de las Americas, Santiago 8320000, Chile. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AUID- ORCID: 0000-0002-9691-5998 AD - Lifestyle Factors with Impact on Ageing and Overall Health (LAH) Research Group, Department of Nursing, University of Valencia, 46010 Valencia, Spain. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno 5290000, Chile. FAU - Stubbs, Brendon AU - Stubbs B AUID- ORCID: 0000-0001-7387-3791 AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London WC2R 2LS, UK. AD - Center for Sport Science and University Sports, University of Vienna, 1010 Wien, Austria. FAU - Smith, Lee AU - Smith L AUID- ORCID: 0000-0002-5340-9833 AD - Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UK. AD - Department of Public Health, Faculty of Medicine, Biruni University, Istanbul 34015, Turkey. FAU - Ridgell, Lucille AU - Ridgell L AUID- ORCID: 0009-0001-5956-5925 AD - Carver University, Orlando, FL 32804, USA. FAU - Mino, Camila AU - Mino C AUID- ORCID: 0000-0002-9444-8564 AD - Universidad Internacional para el Desarrollo (UNINDE), Extremadura, 06080 Badajoz, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Guayaquil 0901952, Ecuador. AD - Department of Sport Sciences, Faculty of Sport and Health Sciences, Fit Generation Research Institute, AD500 Andorra la Vella, Andorra. LA - eng PT - Journal Article DEP - 20260720 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13410315 OTO - NOTNLM OT - adolescent OT - avoidance behaviors OT - cross-sectional studies OT - experiential avoidance OT - psychological inflexibility OT - psychological resiliency OT - sleep disturbances COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/20 CRDT- 2026/07/28 01:12 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:12 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - healthcare14142183 [pii] AID - healthcare-14-02183 [pii] AID - 10.3390/healthcare14142183 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jul 20;14(14):2183. doi: 10.3390/healthcare14142183. PMID- 42512211 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20261014 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 7 DP - 2026 Jul 15 TI - Strategies to Promote the Integration of Fermented Foods in the Daily Diet to Improve Children's Health in Capricorn District, South Africa: A Mixed Method Study Protocol. LID - 10.3390/ijerph23070907 [doi] LID - 907 AB - Child health remains a critical global public health concern, with malnutrition, diarrhea and pneumonia consistently driving high morbidity and mortality rates among children under the age of five. The World Health Organization (WHO) estimates that malnutrition accounts for approximately 3.1 million child deaths annually. In South Africa, persistent challenges such as stunting, micronutrient deficiencies, and food insecurity remain prevalent, particularly in rural communities, despite the existing interventions. Fermented foods present a culturally acceptable, affordable, and sustainable strategy to address malnutrition and improve gut health, potentially reducing stunting and diarrheal diseases. This article presents a protocol for a future four-phase mixed-method study that will be conducted to develop and validate strategies to promote the integration of fermented foods into children's daily diets. The researchers will employ an exploratory sequential mixed methods design in three phases for the purpose of the envisaged study: bibliometric analysis, qualitative inquiry through in-depth interviews with caregivers and nurses, and a quantitative survey developed from qualitative findings. By combining qualitative and quantitative data, the study seeks to generate evidence-based, context-specific strategies for policy and programmatic integration. The anticipated outcome is a framework to support the inclusion of fermented foods in child nutrition programs to ensure the improved child health and progress toward the United Nations Sustainable Development Goals (UN SDGs). FAU - Malema, Masilo Isaac AU - Malema MI AUID- ORCID: 0009-0002-3138-656X AD - Department of Public Health, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa, Pretoria 0208, South Africa. AD - Quality Management Directorate, Walter Sisulu University, Komani Campus, No. 280 Shepstone Road, East London 5200, South Africa. FAU - Matlala, Sogo France AU - Matlala SF AUID- ORCID: 0000-0002-2291-6779 AD - Department of Public Health, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa, Pretoria 0208, South Africa. FAU - Chelule, Paul Kiprono AU - Chelule PK AUID- ORCID: 0000-0002-3477-3242 AD - Department of Public Health, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa, Pretoria 0208, South Africa. LA - eng PT - Journal Article DEP - 20260715 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - South Africa MH - *Fermented Foods MH - Child, Preschool MH - *Child Health MH - *Diet MH - Infant MH - Research Design PMC - PMC13411124 OTO - NOTNLM OT - child nutrition OT - fermented foods OT - gut health OT - mixed methods research OT - strategy development OT - traditional diets COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/15 CRDT- 2026/07/28 01:11 PHST- 2026/03/11 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:11 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - ijerph23070907 [pii] AID - ijerph-23-00907 [pii] AID - 10.3390/ijerph23070907 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Jul 15;23(7):907. doi: 10.3390/ijerph23070907. PMID- 42512071 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 14 IP - 7 DP - 2026 Jul 16 TI - The Limited Diagnostic Utility of Metabolic and Inflammatory Indices in Adolescent Polycystic Ovary Syndrome: A Case-Control Study. LID - 10.3390/biomedicines14071598 [doi] LID - 1598 AB - Background: The aim of this study was to evaluate the clinical and diagnostic utility of metabolic and systemic inflammatory marker indices in adolescent patients with polycystic ovary syndrome (PCOS). Methods: This retrospective case-control study included 63 adolescent girls diagnosed with PCOS, based on the strict presence of both menstrual irregularity and hyperandrogenism, and 63 healthy controls matched for age and body mass index (BMI). Fasting blood glucose (FBG), fasting insulin (FI), and lipid profiles were measured. Metabolic indices, including the Triglyceride-Glucose (TyG) index, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), and Metabolic Score for Insulin Resistance (METS-IR), as well as systemic inflammatory indices (Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and the Aggregate Index of Systemic Inflammation (AISI)), were calculated. The diagnostic performance of these markers was evaluated using Receiver Operating Characteristic (ROC) curves and binary logistic regression analyses. Results: No statistically significant difference was observed between the PCOS and control groups in terms of age and BMI (p > 0.05). FBG levels (p = 0.001) and the TyG index (p = 0.028) were found to be significantly higher in the PCOS group. However, no significant differences were observed between the groups in terms of other metabolic indices (HOMA-IR, METS-IR) and systemic inflammatory markers (SII, SIRI, AISI). In the ROC analysis, only the TyG index demonstrated statistically significant but weak discriminatory power for PCOS (AUC = 0.614; 95% CI: 0.515-0.712; p = 0.028). Furthermore, binary logistic regression analysis revealed that the TyG index was not an independent predictor of PCOS after adjustment. Conclusions: While early metabolic signals such as elevated FBG and TyG index were detected, the evaluated systemic inflammatory indices did not demonstrate significant differences. However, the weak discriminatory capacity of the TyG index and the failure of other composite indices restrict their clinical utility. Therefore, these biomarkers cannot be recommended as reliable standalone diagnostic tools in adolescent PCOS. FAU - Ustebay, Sefer AU - Ustebay S AUID- ORCID: 0000-0003-1507-5921 AD - Department of Pediatrics, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Deniz, Rulin AU - Deniz R AUID- ORCID: 0000-0002-7306-8212 AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Tigli, Alihan AU - Tigli A AUID- ORCID: 0000-0002-9404-4869 AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Akinci, Guzide Ece AU - Akinci GE AUID- ORCID: 0000-0003-2782-1143 AD - Gynecology and Obstetrics Clinic, Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital, 34785 Istanbul, Turkey. FAU - Uzuner, Muhammet Bora AU - Uzuner MB AUID- ORCID: 0000-0001-6557-3086 AD - Department of Anatomy, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Sener, Nazli AU - Sener N AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Degirmenci, Yasemin Ercan AU - Degirmenci YE AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Ustebay, Dondu Ulker AU - Ustebay DU AD - Department of Pediatric Neurology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Karakoc, Oguzhan AU - Karakoc O AUID- ORCID: 0000-0001-7918-4524 AD - Gynecology and Obstetrics Clinic, Bandirma Training and Research Hospital, 10200 Bandirma, Turkey. FAU - Yardibi, Yasin Selcuk AU - Yardibi YS AUID- ORCID: 0009-0006-8059-3206 AD - Department of Pediatrics, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Almak, Deniz AU - Almak D AUID- ORCID: 0000-0001-6744-5299 AD - Bandirma No. 1 Family Health Centre, Balikesir Provincial Health Directorate, 10200 Bandirma, Turkey. FAU - Baykus, Yakup AU - Baykus Y AUID- ORCID: 0000-0001-5730-8477 AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. LA - eng PT - Journal Article DEP - 20260716 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC13406398 OTO - NOTNLM OT - TyG index OT - adolescence OT - biomarkers OT - inflammation OT - insulin resistance OT - polycystic ovary syndrome COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:10 PHST- 2026/06/09 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:10 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - biomedicines14071598 [pii] AID - biomedicines-14-01598 [pii] AID - 10.3390/biomedicines14071598 [doi] PST - epublish SO - Biomedicines. 2026 Jul 16;14(7):1598. doi: 10.3390/biomedicines14071598. PMID- 42510293 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 7 DP - 2026 Jul 11 TI - Acceptability, Perceived Feasibility and Perceived Impact of an Acceptance and Commitment Therapy-Informed Emotion Regulation Program to Assist Parents in Supporting Their Children's Physical Activity: A Qualitative Proof-of-Concept Study. LID - 10.3390/bs16071172 [doi] LID - 1172 AB - Insufficient physical activity (PA) among children remains a public health concern, and parental support is a consistent correlate of child PA. Existing family-based PA interventions have shown modest effects, suggesting a need to address emotional barriers that interfere with parents' support follow-through. This Phase IIa proof-of-concept study examined the acceptability and perceived feasibility of a remotely delivered Acceptance and Commitment Therapy-informed emotion regulation program for parents of children not meeting PA guidelines, and explored perceived changes in parental support. Twenty-one Canadian parents of children aged 6 to 12 years began three 20 to 30 min parent-only online workshops delivered over three weeks; 15 completed all workshops and 12 completed a semi-structured exit interview. Cross-case thematic analysis generated three themes. Parents described the program as acceptable, accessible, and supportive; reported that strategies were feasible to apply and helped them support PA in more flexible, less perfectionistic, and more values-consistent ways; and identified refinements, including stronger support for sustained engagement, greater interactivity, and child inclusion where appropriate. Findings suggest preliminary promise and support further optimization and mixed-method testing of measurable changes in parental support and child or family PA. FAU - Lee, Alfred S Y AU - Lee ASY AUID- ORCID: 0000-0002-8837-7085 AD - Behavioural Medicine Laboratory, Faculty of Education, School of Exercise Science, Physical and Health Education, University of Victoria, P.O. Box 3010 STN CSC, Victoria, BC V8W 3N4, Canada. FAU - Manankil-Lakusta, Alyssa T K AU - Manankil-Lakusta ATK AD - Behavioural Medicine Laboratory, Faculty of Education, School of Exercise Science, Physical and Health Education, University of Victoria, P.O. Box 3010 STN CSC, Victoria, BC V8W 3N4, Canada. FAU - Rhodes, Ryan E AU - Rhodes RE AD - Behavioural Medicine Laboratory, Faculty of Education, School of Exercise Science, Physical and Health Education, University of Victoria, P.O. Box 3010 STN CSC, Victoria, BC V8W 3N4, Canada. LA - eng PT - Journal Article DEP - 20260711 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13405513 OTO - NOTNLM OT - MVPA OT - acceptance and commitment therapy OT - emotional regulation OT - online workshops OT - parental support COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/11 CRDT- 2026/07/28 01:02 PHST- 2026/05/22 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:02 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - bs16071172 [pii] AID - behavsci-16-01172 [pii] AID - 10.3390/bs16071172 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jul 11;16(7):1172. doi: 10.3390/bs16071172. PMID- 42510283 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 7 DP - 2026 Jul 10 TI - Effects of a Cognitively Enriched Playful Physical Activity Program on Executive Functions and School Readiness in Preschool Children. LID - 10.3390/bs16071162 [doi] LID - 1162 AB - Executive functions (EFs) are foundational for early learning and school readiness. Interventions that couple motor engagement with explicit cognitive demands may offer an efficient approach to support EFs during preschool years. This exploratory randomized controlled trial examined the preliminary effects of an 8-week Playful Physical Activities (PPA) program on EF and school readiness. Preschool children were randomized to (i) PPA, a structured program integrating executive challenges (response inhibition, working memory, and planning) into movement games, or (ii) an active control receiving the regular physical education curriculum (3 sessions/week, 60 min/session, 8 weeks). Outcomes were assessed before and after the intervention and included Go/No-Go error rate, BVMT-R immediate and delayed recall, RCFT copy score, and school readiness domains (mathematical, linguistic, and social competence). Group x Time effects were tested using mixed ANOVA and summarized with partial eta squared (eta(2)p). Between-group post-test differences were quantified using Hedges' g. PPA was associated with greater pre-to-post improvements relative to control in attentional control/inhibition (Go/No-Go errors: eta(2)p = 0.134; g = -1.78) and visuospatial organization/planning (RCFT copy: eta(2)p = 0.307; g = 1.36). Visuospatial memory outcomes showed very large interaction effects (BVMT-R immediate eta(2)p = 0.937, g = 5.14; delayed eta(2)p = 0.854, g = 4.10), but these values are exploratory and should not be emphasized as the primary evidence for cognitive improvement because the BVMT-R was used as a non-normed raw-score index outside its validated age range in this preschool sample. School readiness indicators showed favorable changes across mathematical, linguistic, and social competence (eta(2)p = 0.514, 0.385, and 0.337; g = 1.95, 2.05, and 1.31, respectively). Overall, these preliminary findings suggest that cognitively enriched movement may support EF-related performance and school-readiness indicators, but they should not be interpreted as definitive proof of efficacy. Larger prospectively registered trials with balanced groups, age-appropriate outcome measures, and stronger fidelity documentation are needed before firm recommendations can be made. FAU - Chikha, Anis Ben AU - Chikha AB AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Physical Activity, Sport and Health, Research Unit (UR18JS01), National Observatory of Sport, Tunis 1003, Tunisia. FAU - Eken, Ozgur AU - Eken O AUID- ORCID: 0000-0002-5488-3158 AD - Department of Physical Education and Sport Teaching, Faculty of Sports Sciences, Inonu University, Malatya 44280, Turkiye. FAU - Arslanoglu, Birgul AU - Arslanoglu B AD - Department of Humanities and Social Sciences, Faculty of Sciences and Letters, Istanbul Technical University, Istanbul 34469, Turkiye. FAU - Lousaif, Rahma AU - Lousaif R AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health and Society", Higher Institute of Sport and Physical Education of Ksar-Said, Manouba University, Tunis 2010, Tunisia. FAU - Goumni, Chiraz AU - Goumni C AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health and Society", Higher Institute of Sport and Physical Education of Ksar-Said, Manouba University, Tunis 2010, Tunisia. FAU - Bouallegui, Nejha AU - Bouallegui N AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health and Society", Higher Institute of Sport and Physical Education of Ksar-Said, Manouba University, Tunis 2010, Tunisia. FAU - Calisir, Melih AU - Calisir M AUID- ORCID: 0000-0002-2133-2843 AD - Department of Physical Education and Sport Teaching, Faculty of Sports Sciences, Bitlis Eren University, Bitlis 13000, Turkiye. FAU - Souissi, Nizar AU - Souissi N AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Physical Activity, Sport and Health, Research Unit (UR18JS01), National Observatory of Sport, Tunis 1003, Tunisia. FAU - Aldhahi, Monira I AU - Aldhahi MI AUID- ORCID: 0000-0002-5255-4860 AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng GR - PNURSP2026R286/Princess Nourah bint Abdulrahman University/ PT - Journal Article DEP - 20260710 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13405789 OTO - NOTNLM OT - attention and inhibition OT - cognitively enriched movement OT - executive functions OT - preschool education OT - school readiness OT - visuospatial learning COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/10 CRDT- 2026/07/28 01:02 PHST- 2026/04/30 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:02 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - bs16071162 [pii] AID - behavsci-16-01162 [pii] AID - 10.3390/bs16071162 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jul 10;16(7):1162. doi: 10.3390/bs16071162. PMID- 42510090 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 14 DP - 2026 Jul 16 TI - Interpretable Machine Learning for Predicting Suboptimal 12-Month Growth Response to Recombinant Human Growth Hormone in Children with Idiopathic Short Stature: A Dual-Center External Validation Study. LID - 10.3390/diagnostics16142227 [doi] LID - 2227 AB - Background/Objectives: Individual responses to recombinant human growth hormone (rhGH) therapy in children with idiopathic short stature (ISS) vary substantially, limiting pretreatment decision-making. This study aimed to develop and externally validate an interpretable machine learning model for predicting suboptimal 12-month growth response to rhGH therapy. Methods: In this retrospective dual-center study, 901 children from Center 1 were used for model development and internal testing, and 51 children from Center 2 formed an independent external validation cohort. Routinely collected baseline demographic, laboratory, hormonal, radiographic, and family-history variables were used to develop multiple machine learning models. A soft-voting ensemble classifier was constructed and interpreted using SHapley Additive exPlanations (SHAP). The primary outcome was suboptimal growth response, defined as failure to achieve a height gain of at least 0.5 standard deviation score after 12 months of treatment. Results: The optimized ensemble model showed strong discrimination in the internal test set, with an area under the receiver operating characteristic curve of 0.927, and maintained robust performance in the external validation cohort, with an AUC of 0.897. SHAP analysis identified luteinizing hormone, body mass index, TW3 RUS bone age, and insulin-like growth factor 1 as the leading contributors to predicted suboptimal-response risk. Conclusions: An interpretable ensemble machine learning model based on routinely available pretreatment data can predict suboptimal short-term rhGH response in children with ISS and may support individualized risk stratification in pediatric endocrine practice. Clinical trial registration was not required because this was a retrospective analysis. FAU - Yang, Chuanyu AU - Yang C AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Shao, Yifeng AU - Shao Y AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Jiang, Chengyang AU - Jiang C AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Zhang, Runmin AU - Zhang R AD - China United Network Communications Group, Beijing Branch, Beijing 100009, China. FAU - Wang, Jian AU - Wang J AD - Department of Pediatrics, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China. FAU - Chen, Xinlin AU - Chen X AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Zeng, Yuyuan AU - Zeng Y AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - An, Qi AU - An Q AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Peng, Nan AU - Peng N AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Wang, Xi AU - Wang X AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Zhou, Bo AU - Zhou B AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Wang, Jianhong AU - Wang J AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Wang, Lin AU - Wang L AUID- ORCID: 0000-0001-5536-781X AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. LA - eng GR - 2024-1-1131/the Special Research Project of Capital Health Development/ GR - AL-02-19/High-level Public Health Talents Training Plan/ GR - XZYC-2025-07/New Quality Foundation of Capital Institute of Pediatrics/ PT - Journal Article DEP - 20260716 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13408863 OTO - NOTNLM OT - clinical prediction model OT - idiopathic short stature OT - interpretability OT - machine learning OT - recombinant human growth hormone COIS- Author Runmin Zhang was employed by China United Network Communications Group, Beijing Branch. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:01 PHST- 2026/06/10 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - diagnostics16142227 [pii] AID - diagnostics-16-02227 [pii] AID - 10.3390/diagnostics16142227 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Jul 16;16(14):2227. doi: 10.3390/diagnostics16142227. PMID- 42509980 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 20 TI - Correlation Between Ambulatory Blood Pressure Monitoring and Target Organ Damage in Children. LID - 10.3390/children13070955 [doi] LID - 955 AB - BACKGROUND: Ambulatory blood pressure monitoring (ABPM) offers a comprehensive assessment of mean blood pressure (BP), circadian patterns, and out-of-office hypertension phenotypes. We evaluated the association of ABPM parameters with left ventricular hypertrophy (LVH) and hypertensive retinopathy (HRP) in children with hypertension. METHODS: This retrospective analysis included 269 children who underwent ABPM at a tertiary care facility. Multivariable logistic regression was used to evaluate associations between BP Z scores and target organ damage (TOD), adjusting for age, sex, and body mass index standard deviation score. Machine learning techniques (logistic regression, random forest, and multilayer perceptron) were also evaluated using 10-fold cross-validation across exploratory combinations of the 90th or 95th percentiles and BP-load thresholds of 25% or 50%. RESULTS: LVH was detected in 45/247 patients (18%) and HRP was observed in 22/240 patients (9%). The 24 h systolic BP Z score was independently associated with LVH (adjusted OR 1.44; 95% CI 1.16-1.80; p = 0.001). Cohort-derived systolic Z-score thresholds for LVH were 1.31 for 24 h systolic BP and 1.47 for nighttime systolic BP, corresponding to approximately the 90.6th and 93rd percentiles, respectively. No variable evaluated was independently associated with retinopathy. Logistic regression using the 90th percentile/25% load dataset showed the highest performance among the evaluated classifiers, but discrimination was limited (ROC area 0.603; MCC 0.041). CONCLUSIONS: Higher ambulatory systolic BP was independently associated with LVH but not with clinically detected hypertensive retinopathy. ABPM values at or above the 90th percentile and a systolic load of >/=25% may help identify children at increased risk of TOD, although these thresholds remain exploratory and require prospective external validation. FAU - Ozturk, Musa AU - Ozturk M AUID- ORCID: 0000-0003-4316-2002 AD - Department of Pediatrics, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Bakirarar, Batuhan AU - Bakirarar B AUID- ORCID: 0000-0002-5662-8193 AD - Department of Biostatistics, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Ozcakar, Zeynep Birsin AU - Ozcakar ZB AUID- ORCID: 0000-0002-6376-9189 AD - Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Cakar, Nilgun AU - Cakar N AD - Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Doganay, Beyza AU - Doganay B AD - Department of Biostatistics, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Tutar, Ercan AU - Tutar E AD - Division of Pediatric Cardiology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Yalcinkaya, Fatos AU - Yalcinkaya F AD - Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. LA - eng PT - Journal Article DEP - 20260720 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406871 OTO - NOTNLM OT - ambulatory blood pressure monitoring OT - childhood hypertension OT - left ventricular hypertrophy OT - machine learning OT - target organ damage COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/20 CRDT- 2026/07/28 01:01 PHST- 2026/06/18 00:00 [received] PHST- 2026/07/15 00:00 [revised] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - children13070955 [pii] AID - children-13-00955 [pii] AID - 10.3390/children13070955 [doi] PST - epublish SO - Children (Basel). 2026 Jul 20;13(7):955. doi: 10.3390/children13070955. PMID- 42509955 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 15 TI - Criterion and Convergent Validity of Youth Physical Activity and Sedentary Behavior Questionnaires in School Settings: A Systematic Review of Current Evidence and Future Perspectives. LID - 10.3390/children13070931 [doi] LID - 931 AB - BACKGROUND/OBJECTIVES: Physical activity and sedentary behavior are key indicators of youth health, and questionnaires offer a cost-effective method for data collection. This systematic review synthesized evidence on the criterion and convergent validity of self-report questionnaires measuring physical activity and sedentary behavior in children and adolescents aged 5-18 years in school settings. METHODS: Searches were conducted in SPORTDiscus, Medline, Scopus, ERIC, Academic Search Complete, Education Source, and the Cochrane Library with no date limits. Included studies compared questionnaire results with established measures and were assessed using the consensus-based standards for the selection of health measurement instruments (COSMIN) checklist. RESULTS: Twenty-two studies covering 16 questionnaires were included; additional outcomes included test-retest reliability, content and construct validity, and psychometric evaluation. Validity correlations ranged from very weak to strong (r = 0.11-0.80; rho = 0.20-0.87), with Bland-Altman agreement (rho = 0.56-0.70) and mean absolute percentage error up to 199.6%. CONCLUSIONS: Eight questionnaires showed acceptable validity and reliability, though research is needed to strengthen evidence on measurement accuracy. FAU - Gagnon, Megane AU - Gagnon M AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Bouqartacha, Salma AU - Bouqartacha S AUID- ORCID: 0009-0000-6749-3047 AD - Department of Anatomy, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Bedard, Eloane AU - Bedard E AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Delattre, Livia AU - Delattre L AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Descarreaux, Martin AU - Descarreaux M AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Guimaraes, Roseane de Fatima AU - Guimaraes RF AUID- ORCID: 0000-0001-8151-7914 AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. LA - eng GR - CMDO/FRQS 35330/Research Network on cardiometabolic health, diabetes and obesity/ GR - UQTR institutional Research Chair on lifestyle habits and health in youth/University of Quebec at Trois-Rivieres/ PT - Journal Article PT - Review DEP - 20260715 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406170 OTO - NOTNLM OT - children and adolescents OT - physical activity OT - questionnaire validity OT - sedentary behavior OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/15 CRDT- 2026/07/28 01:01 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - children13070931 [pii] AID - children-13-00931 [pii] AID - 10.3390/children13070931 [doi] PST - epublish SO - Children (Basel). 2026 Jul 15;13(7):931. doi: 10.3390/children13070931. PMID- 42509940 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 10 TI - Non-Pharmacological and Non-Optical Interventions for Myopia Prevention and Control in Children: A Systematic Review and Meta-Analysis. LID - 10.3390/children13070915 [doi] LID - 915 AB - BACKGROUND: Myopia is projected to affect 50% of the global population by 2050. Its progression increases the risk of severe ocular pathologies, making it imperative to validate safe and effective non-pharmacological prevention interventions. AIM: To evaluate the clinical efficacy of low-level red-light therapy (RLRL) and nutritional supplementation in preventing and controlling myopia progression in children and adolescents. METHODS: This systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD420261301596). Randomized clinical trials in pediatric populations (aged 0-18 years) were included. The primary quantitative outcome measures for myopia were axial length (AL) and spherical equivalent (SE). Risk of bias (RoB 2) and heterogeneity (I(2)) were assessed. RESULTS: 18 articles were included (n = 2438). RLRL demonstrated a significant reduction in axial elongation (mean difference (MD): -0.26 mm; 95% CI: -0.34 to -0.18) and a protective effect on refractive progression (MD: +0.60 D; 95% CI: 0.42 to 0.78), although with high heterogeneity (I(2) > 97%). Nutritional supplementation exhibited a modest, non-significant effect on axial length (-0.22 mm; 95% CI: -0.44 to 0.00), acting primarily as functional support. CONCLUSIONS: RLRL slows ocular elongation and myopia progression. Recent studies provide reassuring evidence regarding its long-term safety when recommended treatment protocols are followed. However, the high heterogeneity among studies, the need for standardized treatment discontinuation strategies, and the limited long-term evidence in geographically and ethnically diverse pediatric populations warrant further investigation. Current evidence is insufficient to demonstrate a consistent clinically meaningful effect of nutritional supplementation on axial elongation. FAU - Dominguez-Morras, Claudia AU - Dominguez-Morras C AD - Faculty of Science, Universidad Publica de Navarra, UPNA, 31008 Pamplona, Spain. FAU - Paniagua Garcia, Miren AU - Paniagua Garcia M AD - Department of Pediatrics, Hospital Universitario de Navarra, HUN, 31008 Pamplona, Spain. FAU - Castro Garrido, Isabel AU - Castro Garrido I AD - Department of Pediatrics, Hospital Universitario de Navarra, HUN, 31008 Pamplona, Spain. FAU - Moreno-Montanes, Javier AU - Moreno-Montanes J AUID- ORCID: 0000-0002-6623-6783 AD - Department of Ophthalmology, Hospital Fundacion Jimenez Diaz, 28040 Madrid, Spain. FAU - Fernandez-Montero, Alejandro AU - Fernandez-Montero A AUID- ORCID: 0000-0002-8741-7401 AD - Instituto de Investigacion Sanitaria de Navarra, IdiSNA, 31008 Pamplona, Spain. AD - Department of Occupational Medicine, Universidad de Navarra, 31008 Pamplona, Spain. FAU - Moreno-Galarraga, Laura AU - Moreno-Galarraga L AUID- ORCID: 0000-0003-0293-0749 AD - Faculty of Science, Universidad Publica de Navarra, UPNA, 31008 Pamplona, Spain. AD - Department of Pediatrics, Hospital Universitario de Navarra, HUN, 31008 Pamplona, Spain. AD - Instituto de Investigacion Sanitaria de Navarra, IdiSNA, 31008 Pamplona, Spain. LA - eng PT - Journal Article PT - Review DEP - 20260710 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406435 OTO - NOTNLM OT - axial length OT - children OT - dietary supplements OT - low-level light therapy OT - myopia OT - photobiomodulation OT - prevention and control OT - spherical equivalent COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/10 CRDT- 2026/07/28 01:01 PHST- 2026/05/22 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - children13070915 [pii] AID - children-13-00915 [pii] AID - 10.3390/children13070915 [doi] PST - epublish SO - Children (Basel). 2026 Jul 10;13(7):915. doi: 10.3390/children13070915. PMID- 42509931 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 8 TI - Validity and Reliability of the Spanish Version of the Children's Self-Perceptions of Adequacy in and Predilection for Physical Activity (CSAPPA) Questionnaire for Primary School Children Aged 6 to 12 Years. LID - 10.3390/children13070906 [doi] LID - 906 AB - INTRODUCTION: Understanding children's physical self-concept is crucial, as it influences motivation, behavior, and physical activity (PA). The Spanish version of the Children's Self-Perceptions of Adequacy in and Predilection for Physical Activity (CSAPPA) assesses the adequacy and predilection for PA, but it is not fully adapted for schoolchildren. Considering the developmental and contextual differences between children and adolescents, adapting and validating this instrument for younger populations is necessary. This study aimed to test the validity and reliability of the CSAPPA for schoolchildren aged 6-12 years (65 boys and 64 girls; mean age 9.63 +/- 1.78 years). METHOD: Comprehension of the CSAPPA was examined through cognitive interviews, and reliability was assessed via a test-retest approach with 129 Spanish schoolchildren. Confirmatory factor analysis (CFA), Cronbach's alpha, and the intraclass correlation coefficient (ICC) were used to evaluate validity and reliability. RESULTS: CFA confirmed the three-factor structure (Adequacy, Predilection, Enjoyment) in children aged 6-12, with excellent fit indices: Chi-square divided by degrees of freedom (chi(2)/df) = 1.179; Root Mean Square Error of Approximation (RMSEA) = 0.037; Comparative Fit Index (CFI) = 0.961; Tucker-Lewis Index (TLI) = 0.953. Test-retest reliability ranged from questionable to good (Cronbach's alpha = 0.622-0.871), except for items 8 and 14. The ICC values indicated moderate to near-perfect (ICC: 0.453-0.871) temporal stability; items 8 and 14 were excluded. CONCLUSIONS: The Spanish CSAPPA demonstrates validity and reliability for assessing self-perceptions related to PA motivation among schoolchildren aged 6-12. As part of the affective domain in the Spanish Physical Literacy Assessment for Children (SPLA-C) model, it shows promise for use in school and sport contexts, supporting the identification of needs and planning interventions to promote active participation and positive development. However, items 8 and 14 demonstrated poor psychometric performance and should be interpreted with caution, requiring further refinement before the instrument can be recommended without reservation. FAU - Pastor-Cisneros, Raquel AU - Pastor-Cisneros R AUID- ORCID: 0000-0001-7305-6783 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AUID- ORCID: 0000-0001-9502-5486 AD - Department of Communication and Education, Universidad Loyola Andalucia, 41704 Sevilla, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Carlos-Vivas, Jorge AU - Carlos-Vivas J AUID- ORCID: 0000-0002-6377-9950 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. LA - eng PT - Journal Article DEP - 20260708 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406152 OTO - NOTNLM OT - educational assessment OT - motivation OT - physical education OT - young children COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/08 CRDT- 2026/07/28 01:01 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - children13070906 [pii] AID - children-13-00906 [pii] AID - 10.3390/children13070906 [doi] PST - epublish SO - Children (Basel). 2026 Jul 8;13(7):906. doi: 10.3390/children13070906. PMID- 42509924 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 6 TI - Chronic Skin Disease, Media Use and Health Values in the Quality of Life of Adolescents. LID - 10.3390/children13070899 [doi] LID - 899 AB - INTRODUCTION: Chronic dermatological diseases that appear in adolescence, such as acne vulgaris, atopic dermatitis, alopecia areata and psoriasis vulgaris, not only cause physical symptoms but also significantly affect young people's quality of life, mental state, self-esteem and social relationships. Social media, especially information spread by influencers, significantly influences adolescents' body image, health-related attitudes and even the quality of the physician-patient relationship. The aim of our study was to explore the relationships between dermatology-related quality of life, media use, health values, body image and self-esteem among adolescents with chronic dermatological diseases. METHODS: In our cross-sectional, quantitative study, we used validated questionnaires (DLQI, EQ-5D-5L, IRVS, Attitude Scale, STAI-Y2, SWLS-H, Rosenberg Scale, BAT), which we supplemented with a media consumption questionnaire of our own design. Structured data collection took place between October 2024 and March 2025, with the participation of 208 adolescents aged 11-18. Data analysis was performed using SPSS 26.0 (Spearman's correlation, Mann-Whitney test). Differences were considered significant at p < 0.05. Ethical approval: BM/22429-1/2024. RESULTS: Acne vulgaris was the most common diagnosis (65%), followed by atopic dermatitis (22%) and psoriasis (11%). Over a quarter of the adolescents (27%) followed influencers who provided skincare advice. The mean daily screen time was 4.5 h, with 3.7 h on smartphones. A longer screen time was significantly correlated with poorer dermatological quality of life. Greater dermatology-related quality of life impairment (higher DLQI scores) was associated with poorer general quality of life (EQ-5D-5L). Following skincare-related influencers was significantly associated with dermatology-related quality of life and anxiety. Conversely, stronger health values were significantly linked to more favourable health behaviors. CONCLUSIONS: In this sample, greater dermatology-related quality-of-life impairment was associated with poorer psychosocial outcomes. Longer screen time was associated with poorer dermatology-related quality of life and less favourable psychosocial outcomes. The novelty of our study lies in the use of a self-developed media consumption questionnaire, which is suitable for the complex mapping of psychological and quality-of-life factors in adolescents. FAU - Dinnyes, Katalin Julianna AU - Dinnyes KJ AUID- ORCID: 0000-0002-1975-7535 AD - Health Behaviour and Development Group, Faculty of Health Sciences and Social Training, University of Szeged, H-6726 Szeged, Hungary. AD - Doctoral School of Education and Society, University of Pecs, H-7622 Pecs, Hungary. FAU - Csoma, Zsanett Renata AU - Csoma ZR AD - Health Behaviour and Development Group, Faculty of Health Sciences and Social Training, University of Szeged, H-6726 Szeged, Hungary. AD - Department of Dermatology and Allergology, Albert Szent-Gyorgyi Clinical Center, University of Szeged, H-6720 Szeged, Hungary. LA - eng PT - Journal Article DEP - 20260706 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406771 OTO - NOTNLM OT - adolescents OT - body image OT - dermatology OT - health values OT - psychodermatology OT - quality of life OT - screen time OT - self-esteem OT - social media use COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/06 CRDT- 2026/07/28 01:01 PHST- 2026/04/26 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - children13070899 [pii] AID - children-13-00899 [pii] AID - 10.3390/children13070899 [doi] PST - epublish SO - Children (Basel). 2026 Jul 6;13(7):899. doi: 10.3390/children13070899. PMID- 42509878 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jun 24 TI - Do School Athletes Really Eat Better? Nutritional and Body Composition Differences in Saudi Adolescents. LID - 10.3390/children13070852 [doi] LID - 852 AB - Background: Obesity among Saudi adolescents has risen sharply, yet whether school athletic participation is associated with students showing improved dietary habits and better anthropometric profiles compared to those of their non-athlete peers remains unclear. This study compared anthropometric indices and dietary habits between school athletes and non-athletes in Riyadh. Methods: A cross-sectional study was conducted with 124 male secondary school students (70 athletes and 54 non-athletes aged 16-17 years) in Riyadh, Saudi Arabia. Athletes were defined as students who reported engaging in vigorous-intensity sport for >/=3 days/week for >/=60 min/session. BMI, body weight, and waist circumference were measured objectively. Dietary habit frequencies across ten food categories were assessed using the validated Arab Teens Lifestyle Study (ATLS) questionnaire. Independent samples t-tests and chi-square tests were used; effect sizes were calculated as Cohen's d. A Bonferroni-corrected threshold (p < 0.005) was applied for multiple dietary comparisons. Results: Athletes had significantly lower BMI (23.64 +/- 5.39 vs. 30.28 +/- 7.25 kg/m(2); p < 0.001, d = 1.06), body weight (p < 0.001, d = 0.93), and waist circumference (85.46 +/- 12.61 vs. 95.50 +/- 17.89 cm; p < 0.001, d = 0.66). Obesity prevalence was 15.7% among athletes versus 51.9% among non-athletes. Of ten dietary variables, only fresh fruit consumption showed a between-group difference (62.9% vs. 40.7% high-frequency; p = 0.010), which did not survive Bonferroni correction. Conclusions: School athletes demonstrated substantially better anthropometric profiles than their non-athlete peers, but dietary habit frequencies were largely similar across both groups. The high obesity prevalence among non-athletes underscores the need for school-based programs that combine structured physical activity with targeted nutrition education. FAU - Alshuwaier, Ghareeb O AU - Alshuwaier GO AUID- ORCID: 0000-0003-3269-9509 AD - Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh 11451, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406725 OTO - NOTNLM OT - Arab adolescents OT - Saudi Vision 2030 OT - central obesity OT - cross-sectional study OT - food frequency OT - overweight OT - physical inactivity OT - school sport COIS- The author declares no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/24 CRDT- 2026/07/28 01:01 PHST- 2026/05/26 00:00 [received] PHST- 2026/06/15 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - children13070852 [pii] AID - children-13-00852 [pii] AID - 10.3390/children13070852 [doi] PST - epublish SO - Children (Basel). 2026 Jun 24;13(7):852. doi: 10.3390/children13070852. PMID- 42509874 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jun 24 TI - Effectiveness of a School Physician-Led Counseling Intervention on Cholesterol Levels and Lifestyle Behaviors in Children with Hypercholesterolemia: A Randomized Controlled Trial. LID - 10.3390/children13070848 [doi] LID - 848 AB - Background: This randomized controlled trial aimed to evaluate the effects of a school physician-led counseling intervention on total cholesterol (TC) levels, adherence to the Mediterranean diet, physical activity, and sedentary behavior in children aged 6-7 years with elevated cholesterol levels in a Mediterranean setting. Methods: A one-year randomized controlled study was conducted among children aged 6-7 years with elevated TC levels, excluding those with familial hypercholesterolemia (FH). Participants were randomly assigned to either a control group (n = 38) or an intervention group (n = 39). All participants received standard care consisting of educational materials and baseline counseling, while the intervention group additionally participated in three structured follow-up counseling sessions conducted by school physicians during the one-year study period. Counseling focused on Mediterranean dietary habits, implementation of basic dietary principles in cases of elevated TC levels, promotion of physical activity, and reduction in sedentary behavior. TC levels were measured at baseline and at the end of the study. Dietary habits, physical activity, and sedentary behavior were assessed using validated questionnaires. For the primary outcome, a descriptive change-from-baseline analysis, unadjusted mean difference, the approximate 95% confidence interval, and Cohen's d effect size were calculated. Results: At baseline, no significant differences in TC levels were observed between groups (p = 0.852). After the intervention, mean TC levels were lower in the intervention group than in the control group (4.977 +/- 0.414 mmol/L vs. 5.137 +/- 0.410 mmol/L); however, the between-group difference did not reach statistical significance (p = 0.089). The unadjusted mean difference at follow-up was -0.160 mmol/L, with an approximate 95% confidence interval from -0.35 to 0.03 and a small-to-moderate effect size in favor of the intervention group (Cohen's d = -0.39). Descriptive change-from-baseline analysis showed a greater mean reduction in TC in the intervention group than in the control group (-0.364 mmol/L vs. -0.195 mmol/L). A statistically significant improvement in adherence to the Mediterranean diet was observed in the intervention group compared with the control group (p < 0.001). Favorable changes were also observed in several physical activity and sedentary behavior variables, including participation in organized physical activity, walking and running activities, and reduced television viewing and video gaming time. Given the exploratory nature of behavioral analyses and the number of physical activity and sedentary behavior outcomes examined, these findings should be interpreted cautiously. Conclusions: The school physician-led counseling intervention did not result in a statistically significant between-group difference in TC levels after one year, although the direction and magnitude of change favored the intervention group. The intervention was associated with improved adherence to the Mediterranean diet and favorable exploratory lifestyle-related behavioral changes. Nevertheless, the findings should be interpreted cautiously in light of the relatively small sample size, non-significant primary outcome, and exploratory nature of behavioral analyses. FAU - Tomelic Ercegovic, Katarina AU - Tomelic Ercegovic K AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Glavas, Josipa AU - Glavas J AUID- ORCID: 0000-0002-8032-3269 AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Sikirica, Ivana AU - Sikirica I AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Vrdoljak, Andrea AU - Vrdoljak A AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Tokic, Helena AU - Tokic H AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Perasovic, Jelica AU - Perasovic J AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Karin, Zeljka AU - Karin Z AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406426 OTO - NOTNLM OT - Mediterranean diet OT - children OT - hypercholesterolemia OT - intervention OT - physical activity OT - prevention COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/24 CRDT- 2026/07/28 01:01 PHST- 2026/05/28 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - children13070848 [pii] AID - children-13-00848 [pii] AID - 10.3390/children13070848 [doi] PST - epublish SO - Children (Basel). 2026 Jun 24;13(7):848. doi: 10.3390/children13070848. PMID- 42509871 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jun 23 TI - Effects of a Structured Resistance Training Program on Muscular Strength and Functional Performance in Children with Autism Spectrum Disorder: A 12-Week Intervention Study. LID - 10.3390/children13070845 [doi] LID - 845 AB - Background/Objectives: Motor impairments, including reduced muscular strength and coordination, are commonly reported in children with autism spectrum disorder (ASD) and may negatively affect functional mobility and participation in daily activities. Despite increasing recognition of these challenges, structured resistance training programs for children with ASD remain limited. This study aimed to examine the effects of a 12-week resistance training program on muscular strength and functional performance in children aged 9-11 years with mild ASD. Methods: A selected-group repeated-measures design was employed. Twenty-eight children with specialist-confirmed mild ASD were allocated to an exercise (n = 14) or control group (n = 14) using a strength-matched allocation procedure. The intervention followed established exercise guidelines for youth. Assessments were conducted at baseline, week 6, and week 12 and included handgrip strength, vertical jump height, and 10-m walk time. Non-parametric Friedman tests assessed changes over time, followed by Durbin-Conover post hoc comparisons where appropriate. Effect sizes (r) were calculated. Results: No significant overall time effect was observed for handgrip strength, although a between-group difference favoring the exercise group was observed at week 6. Vertical jump height demonstrated a significant effect over time, with improvements observed in the exercise group from baseline to week 6 and a between-group difference at week 6. Walking time improved significantly across the study period, with improvements observed in both the exercise and control groups. Conclusions: These findings suggest that structured resistance training is a feasible intervention that may support improvements in physical function in children with mild ASD. Resistance training may therefore represent a useful component of exercise programs aimed at improving functional mobility and participation in children with developmental conditions. FAU - Nowbotsing, Janhavi AU - Nowbotsing J AD - Physical Activity, Sport and Recreation (PhASRec) Research Focus Area, North-West University, Potchefstroom 2531, South Africa. FAU - Erasmus, Petro AU - Erasmus P AUID- ORCID: 0000-0001-8004-3964 AD - Community Psychosocial Research (COMPRES), Psychology, North-West University, Mafikeng Campus, Mmabatho 2735, South Africa. FAU - van Aswegen, Mariaan AU - van Aswegen M AUID- ORCID: 0000-0002-6477-8044 AD - Physical Activity, Sport and Recreation (PhASRec) Research Focus Area, North-West University, Potchefstroom 2531, South Africa. LA - eng PT - Journal Article DEP - 20260623 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406619 OTO - NOTNLM OT - autism spectrum disorder OT - children OT - functional mobility OT - muscle strength OT - physical activity OT - resistance training COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/23 CRDT- 2026/07/28 01:01 PHST- 2026/04/23 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - children13070845 [pii] AID - children-13-00845 [pii] AID - 10.3390/children13070845 [doi] PST - epublish SO - Children (Basel). 2026 Jun 23;13(7):845. doi: 10.3390/children13070845. PMID- 42509549 OWN - NLM STAT- MEDLINE DCOM- 20260728 LR - 20260813 IS - 1465-993X (Electronic) IS - 1465-9921 (Print) IS - 1465-9921 (Linking) VI - 27 IP - 1 DP - 2026 Jul 27 TI - Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE. LID - 10.1186/s12931-026-03840-x [doi] LID - 294 AB - BACKGROUND: The relevance of high-sensitivity C-reactive protein (hsCRP), a marker of low-grade systemic inflammation, remains unclear with regard to its association with severity and clinical outcomes in wheeze/asthma. We aimed to assess the role of hsCRP across different phenotypes and severity levels. METHODS: We studied children with preschool wheeze (>/= 2 episodes), and patients with GINA-defined asthma (school-age/adult) compared with healthy controls (HCs) in the well-characterized ALLIANCE (All Age Asthma Cohort) study. HsCRP was measured (AU5800(R)-CRP-Latex test) in 944 study participants (pediatric: n = 728; adult: n = 216) at baseline. Age-stratified analyses (age groups 0-5, 6-18, >/= 18 years) of standardized log(10)-transformed hsCRP concentrations (age, sex, BMI, site) were performed using univariable tests and regression models. The validated ASSESS score and its dimensions (exacerbations, lung function, inhaled corticosteroids, symptom control) were primary outcomes. RESULTS: Adult patients with asthma showed higher hsCRP than HCs (OR 2.22, 95% CI 1.56-3.24). Across all ages, hsCRP increased with clinical severity of wheeze/asthma. The ASSESS score correlated positively with hsCRP in patients aged >/= 6 years (R = 0.19, p = 0.007). hsCRP was increased in school-age asthmatics with prior exacerbations (OR 1.37, 95% CI 1.01-1.87), and in adult asthmatics with impaired lung function (R = 0.2, p = 0.013). Inhaled corticosteroid use was associated with lower hsCRP in preschool wheezers (OR 0.66, 95% CI 0.50-0.85) but higher levels in adults (OR 1.99, 95% CI 1.02-4.09). CONCLUSIONS: HsCRP was increased in adult asthmatics compared to HCs and was associated with several severity-related clinical characteristics. ICS use was associated with higher hsCRP levels in adults, potentially reflecting greater disease severity, whereas ICS use in preschool wheezers was associated with lower hsCRP levels. These age-dependent effects may mirror varying disease courses across the lifespan and progression of asthma. The association of hsCRP with asthma severity in child- and adulthood may indicate its potential relevance for the course of disease and monitoring clinical outcomes. Future longitudinal studies are needed to assess, whether hsCRP may support therapy monitoring. TRIAL REGISTRATION: ClinicalTrials.gov; Pediatric arm: NCT02496468, Registration date: 03 July 2015; Adult arm: NCT02419274, Registration date: 14 April 2015. CI - (c) 2026. The Author(s). FAU - Lagally, Lena AU - Lagally L AUID- ORCID: 0009-0001-9798-9737 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Pettenkofer School of Public Health, Munich, Germany. FAU - Ullemeyer, Lena AU - Ullemeyer L AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. FAU - Omony, Jimmy AU - Omony J AUID- ORCID: 0000-0001-9983-1039 AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Gottschau, Kristina AU - Gottschau K AUID- ORCID: 0000-0002-0785-9964 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. FAU - Foppiano, Francesco AU - Foppiano F AUID- ORCID: 0009-0002-5650-9984 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Pettenkofer School of Public Health, Munich, Germany. FAU - Abdo, Mustafa AU - Abdo M AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. AD - Department of Pneumology and Critical Care Medicine, Thoraxklinik at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, Heidelberg, Germany. FAU - Veith, Vera AU - Veith V AUID- ORCID: 0009-0002-8731-9702 AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. FAU - Tholken, Clemens AU - Tholken C AUID- ORCID: 0000-0003-4328-9193 AD - Center for Synthetic Microbiology (SYNMIKRO), Philipps-Universitat Marburg, Marburg, Germany. FAU - Hose, Alexander AU - Hose A AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. FAU - Maison, Nicole AU - Maison N AUID- ORCID: 0000-0002-8731-4218 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Grychtol, Ruth AU - Grychtol R AUID- ORCID: 0000-0002-8084-104X AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. FAU - Dittrich, Anna-Maria AU - Dittrich AM AUID- ORCID: 0000-0002-9582-1025 AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. AD - Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. FAU - Riemann, Lennart AU - Riemann L AUID- ORCID: 0000-0002-7188-5227 AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. AD - Institute of Immunology, Hannover Medical School, Hannover, Germany. FAU - Weckmann, Markus AU - Weckmann M AUID- ORCID: 0000-0001-5342-979X AD - University Children's Hospital, Luebeck, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Leibniz Lung Center, Research Center Borstel, Borstel, Germany. FAU - Konig, Inke AU - Konig I AUID- ORCID: 0000-0003-0504-6465 AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Institute for Medical Biometry and Statistics, University Luebeck, University Medical Centre Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. FAU - Kronziel, Lea AU - Kronziel L AUID- ORCID: 0000-0002-2126-6831 AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Institute for Medical Biometry and Statistics, University Luebeck, University Medical Centre Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. FAU - Illi, Sabina AU - Illi S AUID- ORCID: 0000-0003-4994-7732 AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - van Koningsbruggen-Rietschel, Silke AU - van Koningsbruggen-Rietschel S AUID- ORCID: 0000-0002-2222-4238 AD - Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. FAU - Rabe, Klaus F AU - Rabe KF AUID- ORCID: 0000-0002-7020-1401 AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. FAU - Renz, Harald AU - Renz H AUID- ORCID: 0000-0003-0602-7215 AD - Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany. AD - University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany. FAU - Hansen, Gesine AU - Hansen G AUID- ORCID: 0000-0001-5185-9454 AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. AD - Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. FAU - Brinkmann, Folke AU - Brinkmann F AUID- ORCID: 0000-0002-4307-4232 AD - University Children's Hospital, Luebeck, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. FAU - Kopp, Matthias V AU - Kopp MV AUID- ORCID: 0000-0003-1989-5492 AD - University Children's Hospital, Luebeck, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Department of Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland. FAU - von Mutius, Erika AU - von Mutius E AUID- ORCID: 0000-0002-8893-4515 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Bahmer, Thomas AU - Bahmer T AUID- ORCID: 0000-0002-7677-7057 AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. FAU - Ege, Markus AU - Ege M AUID- ORCID: 0000-0001-6643-3923 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Skevaki, Chrysanthi AU - Skevaki C AUID- ORCID: 0009-0006-7522-3294 AD - Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany. AD - University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany. AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA. AD - Centre for Research and Education in Public Health (CEPHRE), Academy of Athens, Athens, Greece. FAU - Schaub, Bianca AU - Schaub B AUID- ORCID: 0000-0003-1652-8873 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. Bianca.Schaub@med.uni-muenchen.de. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. Bianca.Schaub@med.uni-muenchen.de. AD - German Center for Child and Adolescent Health (DZKJ), Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. Bianca.Schaub@med.uni-muenchen.de. CN - ALLIANCE Study Group LA - eng SI - ClinicalTrials.gov/NCT02496468 SI - ClinicalTrials.gov/NCT02419274 PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260727 PL - England TA - Respir Res JT - Respiratory research JID - 101090633 RN - 0 (Biomarkers) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Adolescent MH - Adult MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Middle Aged MH - Young Adult MH - *Asthma/blood/diagnosis/epidemiology MH - Biomarkers/blood MH - *C-Reactive Protein/metabolism MH - Cohort Studies MH - *Phenotype MH - *Respiratory Sounds/diagnosis/physiopathology MH - *Severity of Illness Index PMC - PMC13412301 OTO - NOTNLM OT - Asthma OT - Asthma treatment OT - Clinical immunology OT - Epidemiology OT - Inflammation OT - Pediatrics OT - Wheeze COIS- Declarations. Ethics approval and consent to participate: This study involved human participants. A statement within the Methods section to confirm that informed consent was obtained is provided. The study was approved by local ethics committees (lead: University of Luebeck Ethics Committee; reference no. AZ 12-215) and conducted in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: LU, LL, JO, KG, FF, MA, VV, CT, AH, NM, LR, IK, LK, SI, HR, FB have nothing to declare. This work was supported by German Center for Lung Research (DZL) (RG, AMD, KR, GH, MK, ME, EvM, TB, CS, BS); German Federal Ministry of Education and Research (BMBF) (AMD, TB, EvM, GH) and RG: Else-Kroner Fresenius Stiftung; AMD: Vertex Pharmaceutical Inc., German Science Foundation, GSK, Oxford University, Novartis, Hogrefe Publishing Company, Department for Pediatric Psychology, Philipps University Marburg, Vertex Pharmaceuticals, StreamedUP, Christiane-Herzog-Foundation, Austrian Society for Rare Disease, Paul-Ehrlich-Institute, German CF Patient Advocacy Board, German CF Clinical Trial Network Executive Committee, ECFS CTN Executive Committee; MW: DFG, HORIZON-MSCA-2023, COVID-19 Research Initiative Schleswig-Holstein, Follow-Up of Respiratory Infections in Schleswig-Holstein (FRISH), intramural funding of the Christian-Albrechts-University Kiel, the University of Lubeck, and the Leibniz Lung Center, Research Center Borstel; SvKR: Wilsing Stiftung Koln; KR: AstraZeneca, Boehringer Ingelheim, Chiesie, Sanofi & Regeneron, Astra Zeneca, Chiesi Pharmaceuticals, CSL Behring, GlaxoSmithKline, Berlin Chemie, Menarini, German Chest Society (DGP), American Thoracic Society (ATS); GH: Sanofi GmbH, MedUpdate, Abbvie; MK: University of Bern, Allergopharma GmbH, Sanofi Aventis GmbH, Infectopharm GmbH, Gesellschaft Padiatrische Pneumologie e.V; EvM: Bavarian State Ministry of Health and Care for "URS Study", Go Bio Initial Grant, BMBF (Federal Ministry of Education and Research), European Research Council Award, "BEAR Study", O.M. Pharma S.A.; Elsevier GmbH, Georg Thieme Verlag, Springer-Verlag GmbH, Elsevier Ltd., Springer Nature Group, Deutscher Apotheker Verlag; Chinese University of Hongkong, European Commission, AstraZeneca, Imperial College London, OM Pharma S.A., Clarivate; ALK-Abello Arzneimittel GmbH, Japanese Society of Pediatric Allergy and Clinical Immunology (JSPACI), Klinikum Rechts der Isar, University of Colorado, Paul-Martini-Stiftung, Astra Zeneca BioPharmaceuticals Medical, Imperial College London, Children s Hospital Research, Institute of Manitoba Kompetenzzentrum fur Ernahrung (Kern), OM Pharma S.A., Swedish Pediatric Society for Allergy and Lung Medicine, Chinese College of Allergy and Asthma (CCAA), Abbott Laboratories, Deutscher Apotheker Verlag GmbH & Co. KG, Socieded Chilena de Enfermedades Respiratorias, Japanese Society of Allergology, British Society for Asthma and Clinical Immunology, American Academy of Allergy, Asthma & Immunology, European Respiratory Society (ERS), Ludwig Maximilians University Munich, French Health Research Programs' Agency, CONSORZIO FUTURO IN RICERCA, Technical University of Munich (TUM); Deutsches Zentrum fur Lungenforschung (DZL), Fabio Luigi Massimo Ricciardolo/Contatto S.r.l., Fraunhofer ITEM Hannover, MCCA Institut fur Immunologie Uni Wien, Karl-Landsteiner Privatuniversitat f. Gesundheitswissenschaften, Swiss Institute of Allergy and Asthma Research (SIAF) Davos (Associated Institute of the University of Zurich) MHH (Medizinische Hochschule Hannover), Natasha Allergy Research Foundation, Deutsche Forschungsgemeinschaft, Gordon Research Conferences, Socieded Chilena de Enfermedades Respiratorias, Arla, Universitat Leiden, OM Pharma S.A., American Academy of Allergy, Asthma & Clinical Immunology, Deutsche Forschungsgemeinschaft (DFG), European Respiratory Society (ERS), Deutsche Gesellschaft fur Kinder- und Jugendmedizin, World Allergy Organization (WAO), European Parliament, Gesellschaft fur Padiatrische Pneumologie (GPP), European Academy of Allergy and Clinical Immunology (EAACI), Helmholtz Association of German Research Centres, Nobel Conference Stockholm, AAA Congress Sarajevo, Karolinska Institutet, Balzan Foundation, Fondazione Menarini, International Union of Immunological Societies (IUIS), Deutsche Gesellschaft fur Allergologie und klinische Immunologie (DGAKI), Collegium Internationale Allergologicum, European Academy of Allergy & Clinical Immunology (EAACI); EvM has patent No. PCT/EP2019/085016 (Barn dust extract for the prevention and treatment of diseases) issued EU, pending US, Royalties paid to ProtectImmun for patent EP2361632 (Speci fi c environmental bacteria for the protection from and/or the treatment of allergic, chronic in fl ammatory and/or autoimmune disorders, granted on 19 March 2014), and patents EP1411977 (Composition containing bacterial antigens used for the prophylaxis and the treatment of allergic diseases, granted on 18 April 2007), EP1637147 (Stable dust extract for allergy protection, granted on 10 December 2008), and EP 1964570 (Pharmaceutical compound to protect against allergies and in fl ammatory diseases, granted on 21 November 2012) licensed to ProtectImmun. Patent EP21189353.2. 2021. von Mutius E, Rankl B, Bracher F, Muller C, Walker A, Hauck SM, Merl-Pham J, inventors; PROTEINS IDENTIFIED FROM BARN DUST EXTRACT FOR THE PREVENTION AND TREATMENT OF DISEASES. Patent PCT/US2021/016918. 2021. Martinez FD, Vercelli D, Snyder SA, von Mutius E, Pivniouk V, Marques dos Santos M, inventors; THERAPEUTIC FRACTIONS AND PROTEINS FROM ASTHMA-PROTECTIVE FARM DUST. Patent EP21189353.2. 2021. von Mutius E, Rankl B, Bracher F, Muller C, Walker A, Hauck SM, Merl-Pham J, Adler H, Yildirim A.O., Sattler M, Santos Dias Mourao A, Borggrafe J, O Connor P.D., Plettenburg O, inventors; PROTEINS IDENTIFIED FROM BARN DUST EXTRACT FOR THE PREVENTION AND TREATMENT OF DISEASES. Member of the BEAMS External Scientific Advisory Board (ESAB), Member of the Editorial Board of "The Journal of Allergy and Clinical Immunology: In Practice", Member of the Scientific Advisory Board of the Children's Respiratory and Environmental Workgroup (CREW), Member of the International Scientific & Societal Advisory Board (ISSAB) of Utrecht Life Sciences (ULS) University of Utrecht, Member of External Review Panel of the Faculty of Veterinary Science, University of Utrecht, Member of the Selection Committee for the Gottfried Wilhelm Leibniz Programme (DFG), Member of the International Advisory Board of "The Lancet Respiratory Medicine", Member of the Scientific Advisory Board of the CHILD (Canadian Healthy Infant Longitudinal Development) study, McMaster University, Hamilton, Canada, Member of the Pediatric Scientific Advisory Board Iceland, Member of the Abbott Allergy Risk Reduction Advisory Board, Member of the HpVac Scientific Advisory Board, Member of the OM Pharma Scientific Advisory Board, Member of the Award Committee of the International Balzan Foundation, Member of the Scientific Advisory Board for French Prevention National Research Programme, Member of the Scientific Advisory Panel for The Natasha Allergy Research Foundation; TB: Network University Medicine (NUM), Thieme, HealthHero, PneumoLounge, Pohl Boskamp, Pfizer, Chiesi, AstraZeneca, PohlBoskamp, German Society for Pneumology (DGP); ME: Latvian Council of Science, Travel Grant by the International Milk Genomics Consortium 2023 and by Dutch Longfunds 2025; CS: Consultancy and research funding, Bencard Allergie; Consultancy, Novartis Pharma GmbH; BS: GlaxoSmithKline, Novartis, Sanofi, Astra Zeneca, DGAKI. FIR - Burk, Mira IR - Burk M FIR - Contento, Sybille IR - Contento S FIR - Gschwendtner, Silvia IR - Gschwendtner S FIR - Jakwerth, Constanze IR - Jakwerth C FIR - Schloter, Michael IR - Schloter M FIR - Schmidt-Weber, Carsten IR - Schmidt-Weber C FIR - Zeitlmann, Esther IR - Zeitlmann E FIR - Biller, Heike IR - Biller H FIR - Blanke-Roeser, Constantin IR - Blanke-Roeser C FIR - Gaede, Karoline I IR - Gaede KI FIR - Hagedorn, Wiebke IR - Hagedorn W FIR - Jacobs, Nikolas IR - Jacobs N FIR - Kirsten, Anne-Marie IR - Kirsten AM FIR - Nissen, Gyde IR - Nissen G FIR - Nurieva, Wasifa IR - Nurieva W FIR - Pedersen, Frauke IR - Pedersen F FIR - Penner, Loana IR - Penner L FIR - Ricklefs, Isabell IR - Ricklefs I FIR - Szymczak, Silke IR - Szymczak S FIR - Waschki, Benjamin IR - Waschki B FIR - Watz, Henrik IR - Watz H FIR - Wirks, Christopher IR - Wirks C FIR - Bickes, Marie IR - Bickes M FIR - Calvero, Mifflin-Rae IR - Calvero MR FIR - DeLuca, David S IR - DeLuca DS FIR - Gaedcke, Svenja IR - Gaedcke S FIR - Habener, Anika IR - Habener A FIR - Happle, Christine IR - Happle C FIR - Jirmo, Adan Chari IR - Jirmo AC FIR - Liu, Bin IR - Liu B FIR - Foth, Svenja IR - Foth S FIR - Jerrentrup, Inga IR - Jerrentrup I FIR - Weber, Stefanie IR - Weber S FIR - Alejandre Alcazar, Miguel A IR - Alejandre Alcazar MA FIR - Keufken, Lena IR - Keufken L FIR - Rietschel, Ernst IR - Rietschel E FIR - Trojan, Tobias IR - Trojan T FIR - Thomassen, Jan-Christoph IR - Thomassen JC EDAT- 2026/07/28 00:35 MHDA- 2026/07/28 06:37 PMCR- 2026/07/27 CRDT- 2026/07/27 23:35 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 23:35 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.1186/s12931-026-03840-x [pii] AID - 3840 [pii] AID - 10.1186/s12931-026-03840-x [doi] PST - epublish SO - Respir Res. 2026 Jul 27;27(1):294. doi: 10.1186/s12931-026-03840-x. PMID- 42509536 OWN - NLM STAT- MEDLINE DCOM- 20260728 LR - 20260813 IS - 1471-2369 (Electronic) IS - 1471-2369 (Linking) VI - 27 IP - 1 DP - 2026 Jul 25 TI - Examining commonly used equations for estimating the glomerular filtration rate (GFR) in a healthy cohort of children and adolescents. LID - 10.1186/s12882-026-05219-y [doi] LID - 446 AB - BACKGROUND: In this study, we compared established equations for estimating the glomerular filtration rate (GFR) in a cohort of apparently healthy children and adolescents and aimed to evaluate the equations' validity. METHODS: Blood samples and anthropometric data from 4,776 apparently healthy participants (0.25-21 years) were analyzed. The glomerular filtration rate was estimated (eGFR) using the revised Schwartz Bedside (2009), the Cystatin C- and Serum Creatinine- based Schwartz equation, the Chronic Kidney Disease in Children (CKiD) equation, the 3 versions of the U25 (U25cys, U25scr, U25ave), the Serum Creatinine version, as well as the Cystatin-C based equation from the European Kidney Function Consortium (EKFCcr, EKFCcys), the CAPA equation, and the Cystatin C-Creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). The resulting eGFR distributions were compared, and the percentages of eGFR values within the expected physiological eGFR range (90-120 ml/min/1.73 m(2)) were calculated stratified by age and sex. Subsequently, age ranges with implausible distributions were identified. RESULTS: EKFCcr, CKiD, Schwartz, and U25scr yielded the highest proportion of eGFRs within the expected range and showed consistent values across age groups without large jumps. Bland-Altman analysis indicated extremely low biases between Schwartz and EKFCcr and very high biases especially between CKD-EPI, CAPA and Bedside in reference to the other equations. Males showed higher eGFRs than females. CONCLUSIONS: We found that the EKFC equations, Schwartz, and U25 resulted in eGFR distributions within the expected physiological range for an apparently healthy pediatric cohort. Estimates from simpler equations such as Bedside and CAPA were more prone to implausible results. TRIAL REGISTRATION: Clinical trial number NCT02550236 (clinicaltrials.gov, date of registration: 2014-12-15). CI - (c) 2026. The Author(s). FAU - Trenkmann, Luise AU - Trenkmann L AUID- ORCID: 0009-0004-8680-1358 AD - LIFE Child Study, University Hospital for Children and Adolescents, Medical Faculty, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. luise@trenkmann.eu. FAU - Ziegelasch, Niels AU - Ziegelasch N AD - LIFE Child Study, University Hospital for Children and Adolescents, Medical Faculty, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. FAU - Dittrich, Katalin AU - Dittrich K AD - Center of Paediatric Research (CPL), University of Leipzig, 04103, Leipzig, Germany. AD - Hospital for Children and Adolescents, University of Leipzig, Liebigstrasse 20a, 04103, Leipzig, Germany. FAU - Willenberg, Anja AU - Willenberg A AD - Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University Hospital Leipzig, 04103, Leipzig, Germany. FAU - Kiess, Wieland AU - Kiess W AD - LIFE Child Study, University Hospital for Children and Adolescents, Medical Faculty, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. AD - Center of Paediatric Research (CPL), University of Leipzig, 04103, Leipzig, Germany. FAU - Vogel, Mandy AU - Vogel M AD - LIFE Child Study, University Hospital for Children and Adolescents, Medical Faculty, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. AD - Center of Paediatric Research (CPL), University of Leipzig, 04103, Leipzig, Germany. LA - eng SI - ClinicalTrials.gov/NCT02550236 PT - Journal Article PT - Observational Study DEP - 20260725 PL - England TA - BMC Nephrol JT - BMC nephrology JID - 100967793 RN - AYI8EX34EU (Creatinine) RN - 0 (Cystatin C) SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Young Adult MH - Cohort Studies MH - Creatinine/blood MH - Cystatin C/blood MH - *Glomerular Filtration Rate/physiology MH - Reference Values MH - Renal Insufficiency, Chronic/diagnosis PMC - PMC13410585 OTO - NOTNLM OT - Children OT - Creatinine OT - Cystatin C OT - Kidney OT - Pediatric OT - eGFR COIS- Declarations. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards and have been approved by the Ethics Committee of the University of Leipzig (Reg. No. 477-19-09102020). Informed consent was obtained from all individual participants, or their legal guardians, included in the study. The study is registered under the NCT Trial Number: 02550236 at ClinicalTrials.gov, date of registration: 2014-12-15. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/28 00:35 MHDA- 2026/07/28 06:37 PMCR- 2026/07/25 CRDT- 2026/07/27 23:33 PHST- 2025/11/02 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 23:33 [entrez] PHST- 2026/07/25 00:00 [pmc-release] AID - 10.1186/s12882-026-05219-y [pii] AID - 5219 [pii] AID - 10.1186/s12882-026-05219-y [doi] PST - epublish SO - BMC Nephrol. 2026 Jul 25;27(1):446. doi: 10.1186/s12882-026-05219-y. PMID- 42509504 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260928 IS - 1432-2218 (Electronic) IS - 0930-2794 (Print) IS - 0930-2794 (Linking) VI - 40 IP - 9 DP - 2026 Sep TI - Missing data handling in pediatric appendectomy research: current practices and National Surgical Quality Improvement Program (NSQIP) analysis. PG - 8068-8080 LID - 10.1007/s00464-026-13123-7 [doi] AB - BACKGROUND: Appendectomy is a leading pediatric surgical procedure, yet the impact of missing data handling on clinical conclusions remains unexplored in pediatric surgery. This study aimed to identify current reporting practices in the pediatric appendectomy literature and quantify how different missing-data strategies influence the identification of postoperative infectious-complication risk factors. METHODS: A systematic review of pediatric appendectomy literature from 2023 was conducted across PubMed and Web of Science to assess missing data reporting. Subsequently, a retrospective analysis of the National Surgical Quality Improvement Program-Pediatric (NSQIP-P) database (2015-2022) was performed on 142,129 cases. Five strategies were compared: available case analysis, threshold-based exclusion, complete case analysis, simple imputation, and multiple imputation. Multivariable logistic regression models identified risk factors for five infectious outcomes, including combined infectious complications, organ space infections, deep incisional infections, superficial surgical site infections, and wound dehiscence. RESULTS: The literature review identified 116 eligible articles, of which 54.3% failed to mention missing data. Only 7.3% used advanced statistical techniques, while 86.4% reported that a method relied on complete-case analysis. In the NSQIP-P cohort, 39.3% of records had missing values, primarily in height and race. While core predictors like American Society of Anesthesiologists (ASA) class and operative duration remained stable in multivariate logistic regression analysis, variables such as preoperative white blood cell count and anthropometric measurements fluctuated in significance depending on the handling method. Complete case analysis was the most conservative, identifying the fewest significant predictors. CONCLUSION: Methodological transparency regarding missing data is critically lacking in pediatric surgical research. Because the choice of data-handling strategy significantly alters the identification of clinical risk factors, researchers should prioritize multiple imputation over simple exclusion methods. Journals must mandate rigorous reporting of missingness to ensure the reliability of evidence-based surgical guidelines. CI - (c) 2026. The Author(s). FAU - Tsutsumi, Ayaka AU - Tsutsumi A AUID- ORCID: 0009-0008-6511-9666 AD - Department of Pediatric Surgery, SSM Health Cardinal Glennon Children's Hospital, 1465 S Grand Blvd, Saint Louis, MO, 63104, USA. ayaka.tsutsumi@health.slu.edu. FAU - Si, Tong AU - Si T AD - The Advanced Health Data (AHEAD) Institute, Saint Louis University Hospital, St. Louis, MO, USA. FAU - Salas, Joanne AU - Salas J AD - The Advanced Health Data (AHEAD) Institute, Saint Louis University Hospital, St. Louis, MO, USA. FAU - Hargrave, Anna AU - Hargrave A AD - Department of General Surgery, Saint Louis University Hospital, St. Louis, MO, USA. FAU - Trello, Grace AU - Trello G AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Qiu, Jessica AU - Qiu J AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Reddy, Priya AU - Reddy P AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Nash, Maria AU - Nash M AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Kohli, Nikita AU - Kohli N AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Miyata, Shin AU - Miyata S AD - Department of Pediatric Surgery, SSM Health Cardinal Glennon Children's Hospital, 1465 S Grand Blvd, Saint Louis, MO, 63104, USA. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260727 PL - Germany TA - Surg Endosc JT - Surgical endoscopy JID - 8806653 SB - IM MH - *Appendectomy/statistics & numerical data MH - Humans MH - *Quality Improvement MH - Child MH - Postoperative Complications/epidemiology/etiology MH - Retrospective Studies MH - Risk Factors MH - *Research Design/standards MH - Surgical Wound Infection/epidemiology PMC - PMC13582071 OTO - NOTNLM OT - Acute appendicitis OT - Appendectomy OT - Missing data OT - Missingness OT - Pediatric surgery COIS- Declarations. Disclosures: Ayaka Tsutsumi, MD (Corresponding Author), Tong Si, PhD, Joanne Salas, MPH, Anna Hargrave, DO, Grace Trello, BS, Jessica Qiu, BS, Priya Reddy, BS, Maria Nash, BS, Nikita Kohli, BS, Shin Miyata, MD have no conflicts of interest or financial ties to disclose. EDAT- 2026/07/28 00:35 MHDA- 2026/09/17 05:35 PMCR- 2026/07/27 CRDT- 2026/07/27 23:30 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/09/17 05:35 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 23:30 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.1007/s00464-026-13123-7 [pii] AID - 13123 [pii] AID - 10.1007/s00464-026-13123-7 [doi] PST - ppublish SO - Surg Endosc. 2026 Sep;40(9):8068-8080. doi: 10.1007/s00464-026-13123-7. Epub 2026 Jul 27. PMID- 42509183 OWN - NLM STAT- Publisher LR - 20260727 IS - 1555-9823 (Electronic) IS - 0003-1348 (Linking) DP - 2026 Jul 27 TI - Vascular Preservation for Long-term Central Venous Access in Infants: The Facial Vein as an Underutilized Option. PG - 31348261462099 LID - 10.1177/00031348261462099 [doi] AB - Patients in the neonatal intensive care unit (NICU) may require long-term intravenous access for antibiotic administration, parenteral nutrition, resuscitation, and fluid support. In certain populations, particularly those with short bowel syndrome or with intestinal failure, preservation of vascular access is critical, as progressive loss of central venous access remains a major indication for intestinal transplantation and is associated with significant morbidity and mortality. The common facial vein has been sparsely described as an alternative route for central venous access and clinical data describing its outcomes and practical role remain limited. The primary aim of this study is to describe a single-center experience with tunneled facial vein catheter placement in neonates, focusing on feasibility, safety, and its role in emerging strategies directed towards vascular preservation. Data was obtained retrospectively from NICU patients who had a tunneled central venous catheter insertion between 2013 to 2019. A total of 72 upper body, tunneled central venous catheters were placed of which, 48 used the right or left facial vein as the access site, 13 were placed on the right or left internal jugular veins, and 11 of them were placed on the right or left subclavian vein. Evaluated outcomes included the incidence of intra/post operative hemorrhage, vagus nerve injury, cervical hematoma, palsy of mandibular branch of facial nerve, catheter blockage leading to re-operation, catheter infection, and operative time. Patients who had facial vein access were compared to the other upper body sites and the data was analyzed using a Pearson Chi-Squared test. There was no statistical significant difference regarding complications comparing facial vein access with the two aforementioned access sites. In addition, facial vein operative time was significantly shorter compared to internal jugular vein catheter placement. We propose tunneled facial vein catheterization represents a safe, practical, and underutilized option for neonatal central venous access. Its use may be exceptionally valuable in patients requiring long-term therapy in whom preservation of traditional access sites is essential. FAU - Ian, Gonzalez Montanez AU - Ian GM AUID- ORCID: 0009-0002-1237-8353 AD - University of Puerto Rico School of Medicine, San Juan, Puerto Rico. FAU - Juan, Cruz Lopez AU - Juan CL AUID- ORCID: 0009-0000-7096-1825 AD - University of Puerto Rico School of Medicine, San Juan, Puerto Rico. FAU - Paula, Ruiz Gil AU - Paula RG AD - Department of Surgery, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. FAU - Monica, Roman AU - Monica R AUID- ORCID: 0009-0002-0736-7027 AD - Department of Surgery, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. FAU - Jorge, Zequeira AU - Jorge Z AUID- ORCID: 0009-0002-7959-2653 AD - Department of Surgery, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. LA - eng PT - Journal Article DEP - 20260727 PL - United States TA - Am Surg JT - The American surgeon JID - 0370522 SB - IM OTO - NOTNLM OT - facial vein OT - pediatric catheter OT - pediatric central venous access OT - pediatric vascular access failure OT - short bowel syndrome EDAT- 2026/07/28 00:35 MHDA- 2026/07/28 00:35 CRDT- 2026/07/27 22:03 PHST- 2026/07/28 00:35 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 22:03 [entrez] AID - 10.1177/00031348261462099 [doi] PST - aheadofprint SO - Am Surg. 2026 Jul 27:31348261462099. doi: 10.1177/00031348261462099. PMID- 42509057 OWN - NLM STAT- Publisher LR - 20260727 IS - 1878-1861 (Electronic) IS - 1878-1861 (Linking) DP - 2026 Jul 16 TI - Sports nutrition knowledge, beliefs, and dietary practices among African football players: a pan-African cross-sectional study. LID - S1440-2440(26)00287-2 [pii] LID - 10.1016/j.jsams.2026.07.010 [doi] AB - OBJECTIVES: This study assessed sports nutrition knowledge, nutrition-related beliefs, and dietary practices among African football players across all six Confederation of African Football zones and examined how age, sex, education, and competitive level relate to sports nutrition knowledge. DESIGN: Pan-African, descriptive cross-sectional study. METHODS: A total of 1310 players (758 men/boys; 552 women/girls) completed a validated questionnaire adapted from previous literature and the Nutrition for Sport Knowledge Questionnaire. Non-parametric tests (Mann-Whitney U; Kruskal-Wallis with Dunn-Holm correction), Chi-square tests, and Spearman correlations were used to examine group differences and associations. RESULTS: Overall, sports nutrition knowledge was low. Fewer than half of players correctly identified macronutrient content in common foods (carbohydrates 45-53%; protein 23-41%; fat 50-57%). Knowledge of optimal nutrient timing (34-39%) and hydration strategies (<33%) was similarly limited. Belief misconceptions were widespread: 75% endorsed routine supplement use, and nearly half believed iron tablets should be taken for fatigue and pallor. Only 8.5% reported high confidence in their sports nutrition knowledge, most of which originated from internet sources (34%). Although 68% consumed three meals daily, only 26-32% reported daily fruit or vegetable intake, while approximately 40% consumed daily fast food, sweetened beverages, and supplements. Sports nutrition knowledge differed significantly by age, education, and competition level (p < 0.001, respectively), with senior players and those with higher education scoring higher. Women/girls had higher sports nutrition knowledge than men/boys (p < 0.001). CONCLUSIONS: These findings highlight the need for context-specific, evidence-based nutrition education strategies to support healthy and performance-enhancing dietary behaviours among developing and elite football players across Africa. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Elghoul, Yousri AU - Elghoul Y AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Tunisia; Education, Motor Skills, Sports and Health (EM2S), LR19JS01, Tunisia; Union of North African Football (UNAF), Tunisia. FAU - Mwesigwa, Ben AU - Mwesigwa B AD - Council of East and Central Africa Football Association (CECAFA), Kenya; Federation of Uganda Football Associations (FUFA), Uganda. FAU - Douryang, Maurice AU - Douryang M AD - Department of Physiotherapy and Physical Medicine, University of Dschang, Cameroon; Central African Football Federations' Union (UNIFFAC), Gabon. FAU - Frimpong, Ralph AU - Frimpong R AD - Science Department, Abetifi Presbyterian College of Education, Ghana; Union of West African Federations - Zone B (WAFU-B), Cote d'Ivoire. FAU - Mahachi, Carol B AU - Mahachi CB AD - Department of Primary Health Care Sciences, University of Zimbabwe, Faculty of Medicine and Health Sciences, Zimbabwe; Biomedical Sciences Department, Great Zimbabwe University, Simon Mazorodze School of Medical and Health Sciences, Zimbabwe. FAU - Acquaye, Sidney-Rich AU - Acquaye SR AD - Confederation of African Football (CAF), Member Associations Division, Egypt. FAU - Mkumbuzi, Nonhlanhla S AU - Mkumbuzi NS AD - Confederation of African Football (CAF), Member Associations Division, Egypt; Department of Sports, Exercise, and Rehabilitation, Northumbria University, UK; NtombiSport (PTY) Ltd, South Africa. Electronic address: nonhlanhla.mkumbuzi@cafonline.com. LA - eng PT - Journal Article DEP - 20260716 PL - Australia TA - J Sci Med Sport JT - Journal of science and medicine in sport JID - 9812598 SB - IM OTO - NOTNLM OT - African football OT - Dietary habits OT - Elite OT - Nutrition information OT - Sports nutrition knowledge COIS- Declaration of interest statement The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: YE is a paid consultant for UNAF's Member Associations Division; BM is a paid consultant for CECAFA's Member Associations Division; MD is a paid consultant for UNIFFAC's Member Associations Division; RF is a paid consultant for WAFU-B's Member Associations Division; CBM has received payment from CAF for services; S-RA was an employee of CAF's Member Associations Division at the time of the study; NSM, is a paid consultant for CAF's Member Associations Division. EDAT- 2026/07/28 00:35 MHDA- 2026/07/28 00:35 CRDT- 2026/07/27 21:55 PHST- 2026/03/11 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/28 00:35 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 21:55 [entrez] AID - S1440-2440(26)00287-2 [pii] AID - 10.1016/j.jsams.2026.07.010 [doi] PST - aheadofprint SO - J Sci Med Sport. 2026 Jul 16:S1440-2440(26)00287-2. doi: 10.1016/j.jsams.2026.07.010. PMID- 42508118 OWN - NLM STAT- MEDLINE DCOM- 20260906 LR - 20260906 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 525 IP - Pt 3 DP - 2026 Oct 1 TI - Bridging analytical gaps in perchlorate monitoring: a comprehensive study of food contamination and exposure risk in Spain. PG - 150523 LID - S0308-8146(26)02683-X [pii] LID - 10.1016/j.foodchem.2026.150523 [doi] AB - Perchlorate is an emerging contaminant that can impair neurological development by disrupting thyroid function. Diet intake, particularly teas, fruits, and vegetables, is a major exposure pathway. This study developed a rapid, highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method applicable to all regulated food categories. The method's high sensitivity is essential, as it improves dietary exposure assessment and reduces uncertainties in risk evaluation, particularly for vulnerable populations. The method was validated with satisfactory recoveries (71-109%). A total of 115 food samples were analysed, including 28 infant food samples, a category notably underrepresented in European datasets. Perchlorate was detected in 95.7% of samples, with concentrations exceeding the European Union (EU) maximum limit in four cases. Risk assessment showed that infants and toddlers are especially vulnerable, with a Hazard Index, exceeding the safe limit of 1. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Ponz-Perello, Paula AU - Ponz-Perello P AD - Analytical Chemistry Department, University of Valencia, 19(th) Vicent Andres Estelles Av., 46100 Burjassot, Spain. FAU - Esteve-Turrillas, Francesc A AU - Esteve-Turrillas FA AD - Analytical Chemistry Department, University of Valencia, 19(th) Vicent Andres Estelles Av., 46100 Burjassot, Spain. FAU - Pardo, Olga AU - Pardo O AD - Analytical Chemistry Department, University of Valencia, 19(th) Vicent Andres Estelles Av., 46100 Burjassot, Spain. Electronic address: olga.pardo@uv.es. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260722 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 0 (Perchlorates) RN - VLA4NZX2P4 (perchlorate) SB - IM MH - *Perchlorates/analysis MH - *Food Contamination/analysis MH - Spain MH - Humans MH - *Tandem Mass Spectrometry/methods MH - Risk Assessment MH - *Dietary Exposure/analysis MH - Infant MH - *Liquid Chromatography-Mass Spectrometry/methods MH - Vegetables/chemistry OTO - NOTNLM OT - Contaminants OT - Dietary exposure OT - Infant population OT - Monitoring OT - Perchlorate OT - Risk assessment COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/27 18:35 MHDA- 2026/09/06 05:40 CRDT- 2026/07/27 17:59 PHST- 2026/01/07 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/06 05:40 [medline] PHST- 2026/07/27 18:35 [pubmed] PHST- 2026/07/27 17:59 [entrez] AID - S0308-8146(26)02683-X [pii] AID - 10.1016/j.foodchem.2026.150523 [doi] PST - ppublish SO - Food Chem. 2026 Oct 1;525(Pt 3):150523. doi: 10.1016/j.foodchem.2026.150523. Epub 2026 Jul 22. PMID- 42507676 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - An automated approach to extracting head and brain circumference from MRI datasets. PG - e0352445 LID - 10.1371/journal.pone.0352445 [doi] LID - e0352445 AB - Head circumference is a fundamental biometric parameter for brain growth in both the clinical pediatric setting and in developmental neuroscience. However, the gold standard for obtaining head circumference by manual tape measurement is notoriously error-prone. Further, while it is known that the growth trajectories of head and brain differ over time, a systematic comparison of these two parameters as a function of age does not yet exist. We developed a new and automated algorithm for obtaining head and brain circumference from MRI data. The algorithm mimics manual head circumference measurement by placing a convex hull around axial slices which must intersect with predefined anatomical landmarks. Several differently-tilted iterations are run and results are combined. In addition to obtaining head circumference, the approach can also be applied to gray matter only, providing "brain circumference" (gray matter hull perimeter) at the same level as head circumference. To assess validity, we used T1-weighted 3D datasets (n = 153) with available, manually measured head circumference values (age range 0-226 months [0-18.8 years]). To assess test-retest reliability, a second dataset (n = 3 with 40 scans each) was used. When compared with the current gold standard (manual measure), high validity was demonstrated for the new approach, with no systematic bias. The algorithm also showed a very high reliability across multiple measurements. Developmental trajectories of both head and brain circumference were generated and compared. In summary, the algorithm represents a valid and reliable method for the automated determination of head as well as brain circumference. It offers an objective way to assess these parameters in retrospect and prospectively, and may shed light on specific clinical situations where they differ, such as in the presence of enlarged subarachnoid spaces. CI - Copyright: (c) 2026 Klischat, Wilke. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Klischat, Jasmin AU - Klischat J AUID- ORCID: 0009-0008-1114-9122 AD - Department of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology, Social Paediatrics, University Children's Hospital, Tubingen, Germany. AD - Experimental Pediatric Neuroimaging, Children's Hospital and Department of Neuroradiology, University of Tubingen, Germany. FAU - Wilke, Marko AU - Wilke M AUID- ORCID: 0000-0001-5655-027X AD - Department of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology, Social Paediatrics, University Children's Hospital, Tubingen, Germany. AD - Experimental Pediatric Neuroimaging, Children's Hospital and Department of Neuroradiology, University of Tubingen, Germany. LA - eng PT - Journal Article DEP - 20260727 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Magnetic Resonance Imaging/methods MH - *Brain/anatomy & histology/growth & development MH - *Head/anatomy & histology MH - Algorithms MH - Child, Preschool MH - Child MH - Infant MH - Adolescent MH - Female MH - Infant, Newborn MH - Male MH - Reproducibility of Results MH - *Cephalometry/methods MH - Image Processing, Computer-Assisted/methods PMC - PMC13405294 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/27 18:35 MHDA- 2026/07/27 18:36 PMCR- 2026/07/27 CRDT- 2026/07/27 13:33 PHST- 2025/09/26 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/27 18:36 [medline] PHST- 2026/07/27 18:35 [pubmed] PHST- 2026/07/27 13:33 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - PONE-D-25-51960 [pii] AID - 10.1371/journal.pone.0352445 [doi] PST - epublish SO - PLoS One. 2026 Jul 27;21(7):e0352445. doi: 10.1371/journal.pone.0352445. eCollection 2026. PMID- 42507667 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - An evaluation of a breastfeeding peer support service in North East England: A qualitative study with service users, practitioners and volunteers. PG - e0354027 LID - 10.1371/journal.pone.0354027 [doi] LID - e0354027 AB - BACKGROUND: Breastfeeding has health benefits for women and infants. Although the WHO recommends that infants are breastfed exclusively for the first six months, exclusive breastfeeding rates remain low in the UK, with many women stopping breastfeeding within six weeks of their infant's birth. Many women face challenges initiating and continuing breastfeeding, including low confidence, limited support and misinformation. Breastfeeding peer support (BPS) services play a vital role in supporting women to continue to breastfeed by connecting new mothers with trained volunteers who offer advice, emotional encouragement and reliable information. METHODS: This study aimed to undertake a formative evaluation of the BPS service in Newcastle upon Tyne from the perspective of those who deliver the services, the wider healthcare team and mothers' experiences of utilising the service. This evaluation used a qualitative design, consisting of one-to-one semi-structured interviews with practitioners, volunteers, healthcare professionals and service users. Recruitment took place between 28th March - 14th May 2025. Recorded interview data were transcribed verbatim and analysed using Braun and Clarke's coding reliability thematic analysis. RESULTS: Twenty-two interviews were conducted (n = 11 practitioners, volunteers and healthcare professionals and n = 11 service users). Analysis identified four themes: mechanisms of the service; support offered by the service; outcomes of the service, and challenges to service delivery. Overall, the BPS was considered a supportive service by participants. CONCLUSIONS: The normalisation of breastfeeding was seen as crucial to the service, while service users described that the emotional support provided helped to increase their confidence in breastfeeding. Challenges were identified for the service, including engaging those aged under 25 years and those for whom English is a second language. These findings will be used to inform the future development of the service. CI - Copyright: (c) 2026 Brennan-Tovey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Brennan-Tovey, Kerry AU - Brennan-Tovey K AUID- ORCID: 0000-0002-5516-6230 AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Barrett, Simon AU - Barrett S AUID- ORCID: 0000-0002-8216-2999 AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Hayes, Louise AU - Hayes L AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Moffat, Malcolm AU - Moffat M AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Nguyen, Gina AU - Nguyen G AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Aquino, Maria Raisa Jessica Ryc AU - Aquino MRJR AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Rankin, Judith AU - Rankin J AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. LA - eng PT - Journal Article DEP - 20260727 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - *Peer Group MH - *Social Support MH - Adult MH - England MH - *Volunteers/psychology MH - Qualitative Research MH - Mothers/psychology MH - Infant MH - Health Personnel/psychology MH - Infant, Newborn PMC - PMC13405085 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/27 18:35 MHDA- 2026/07/27 18:36 PMCR- 2026/07/27 CRDT- 2026/07/27 13:33 PHST- 2026/02/09 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/27 18:36 [medline] PHST- 2026/07/27 18:35 [pubmed] PHST- 2026/07/27 13:33 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - PONE-D-26-06611 [pii] AID - 10.1371/journal.pone.0354027 [doi] PST - epublish SO - PLoS One. 2026 Jul 27;21(7):e0354027. doi: 10.1371/journal.pone.0354027. eCollection 2026. PMID- 42507462 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261016 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 180 IP - 10 DP - 2026 Oct 1 TI - Family-Centered Child Obesity Treatment: The TEAM UP Randomized Clinical Trial. PG - 1076-1084 LID - 10.1001/jamapediatrics.2026.3067 [doi] AB - IMPORTANCE: Families have limited access to pediatric weight management services. OBJECTIVE: To compare the effectiveness of enhanced standard of care (ESOC) with family-based behavioral treatment (FBT) vs ESOC alone in reducing percent over median body mass index (percent median BMI) among children and adolescents with obesity. ESOC+FBT was hypothesized to reduce relative weight more than would ESOC alone. DESIGN, SETTING, AND PARTICIPANTS: This was a pragmatic, comparative-effectiveness randomized clinical trial (2019-2024). Data collectors were blinded, and patients were followed up at 18 months. The setting included a total of 41 primary care clinical practices in Louisiana, New York, Missouri, and Illinois. Children and adolescents aged 6 to 15 years with obesity were referred by their primary care practitioner (PCP) or self-selected into the trial. INTERVENTIONS: ESOC was led by the PCP and intensified depending on a child's response. ESOC+FBT included all ESOC components plus meetings with an FBT interventionist, focusing on nutritious eating, physical activity, positive parenting strategies, and management of social and environmental cues. Both interventions lasted 12 months. MAIN OUTCOMES AND MEASURES: Change in percent median BMI at 12 months (end of treatment). RESULTS: A total of 1631 parents completed the web screen for their child, and 901 parent-child dyads were excluded or declined participation before randomization. The final sample of 730 children, each with a participating parent, had a mean (SD) age of 10.8 (2.5) years, 387 (54%) were female, 337 (47%) had Medicaid, and 160 (22%) had food insecurity. At the end of the treatment period, children in the group receiving ESOC+FBT experienced a significant reduction in percent median BMI (-6.4; 95% CI, -8.29 to -4.43) vs ESOC (-2.6; 95% CI, -4.46 to -0.71), with a mean between-group difference of -3.8 units (95% CI, -6.20 to -1.34 units; P = .002). Children's quality of life improved across both treatment arms at months 12 and 18. Similarly, weight-associated quality of life improved in both treatment arms, with greater improvements in ESOC+FBT at the end of the treatment period (6.8; 95% CI, 5.33-8.30 vs 4.8; 95% CI, 3.40-6.17; difference, 2.0 units; 95% CI, 0.05-4.00 units). There were no adverse events related to trial participation. CONCLUSIONS AND RELEVANCE: Results of this randomized clinical trial show that ESOC+FBT demonstrated a significantly larger reduction in child percent median BMI than did ESOC alone. These findings support the added value of incorporating FBT into pediatric primary care settings and its feasibility in reaching a geographically and socioeconomically diverse patient population. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03843424. FAU - Staiano, Amanda E AU - Staiano AE AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana. FAU - Cook, Stephen R AU - Cook SR AD - University of Rochester Medical Center, Rochester, New York. FAU - Stein, Richard I AU - Stein RI AD - Washington University in St. Louis, St. Louis, Missouri. FAU - Button, Alyssa M AU - Button AM AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana. AD - Virginia Commonwealth University, Richmond. FAU - Newton, Robert L Jr AU - Newton RL Jr AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana. FAU - Beyl, Robbie A AU - Beyl RA AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana. FAU - Baker, Alison AU - Baker A AD - American Academy of Pediatrics, Itasca, Illinois. FAU - Lindros, Jeanne AU - Lindros J AD - American Academy of Pediatrics, Itasca, Illinois. FAU - Conn, Anne-Marie AU - Conn AM AD - University of Rochester Medical Center, Rochester, New York. FAU - Braddock, Amy S AU - Braddock AS AD - University of Missouri, Columbia. FAU - Welch, R Robinson AU - Welch RR AD - Washington University in St. Louis, St. Louis, Missouri. FAU - Wilfley, Denise E AU - Wilfley DE AD - Washington University in St. Louis, St. Louis, Missouri. CN - TEAM UP Research Group LA - eng SI - ClinicalTrials.gov/NCT03843424 PT - Journal Article PT - Multicenter Study PT - Pragmatic Clinical Trial PT - Randomized Controlled Trial PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 SB - IM EIN - JAMA Pediatr. 2026 Oct 1;180(10):1173. doi: 10.1001/jamapediatrics.2026.4806. PMID: 42832219 MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - *Pediatric Obesity/therapy MH - *Behavior Therapy/methods MH - *Family Therapy/methods MH - Body Mass Index MH - Treatment Outcome PMC - PMC13409124 COIS- Conflict of Interest Disclosures: Dr Staiano reported receiving grants from Patient-Centered Outcomes Research Institute (PCORI), Louisiana Blue, Louisiana Healthcare Connections, and the National Institutes of Health (NIH) during the conduct of the study. Dr Cook reported receiving grants from PCORI during the conduct of the study. Dr Stein reported receiving grants from Washington University School of Medicine during the conduct of the study and grants from the NIH and Centers for Disease Control and Prevention (CDC) outside the submitted work. Dr Newton reported receiving grants from PCORI during the conduct of the study. Dr Beyl reported receiving grants from PCORI during the conduct of the study. Ms Baker reported receiving grants from PCORI during the conduct of the study. Ms Lindros reported receiving subcontracts from Public Health Institute, Massachusetts General Hospital, Veritas Management, Association of Diabetes Care and Education Specialists, and Vanderbilt University. Dr Wilfley reported receiving grants from PCORI during the conduct of the study; consulting fees from Novo Nordisk outside the submitted work; and serving as coinvestigator/eHealth-based treatment of adolescent obesity with low energy diet and semaglutide (eBATTLE Obesity [principal investigator, Joran Hjelmesaeth; funding body: The Norwegian Health Authority]), principal investigator (MPI)/Advancing Health Equity Through Community-Clinical Integration of Nutrition, Physical Activity, and Health Care in Historically Excluded Communities in the St. Louis Region (NCCDPHP 1NU58DP007643-01-00), principal investigator (MPI)/Increasing Access to US Preventive Services Task Force-Recommended Obesity Care for Youth and Adults Who Are Recipients of Medicaid: Evaluation of a Comprehensive Multidisciplinary Obesity Care Training Program in FQHCs, principal investigator (MPI)/Leveraging Interactive Digital Technology to Increase Access to Family-Based Behavioral Treatment for Childhood Obesity, and co-chief investigator/Bringing Fields Together: Identifying Individuals at Risk of Eating Disorders in Weight Management Program (The Australian National Health and Medical Research Council Ideas Grant). No other disclosures were reported. FIR - Fowler, Lauren IR - Fowler L FIR - Lima, Angela IR - Lima A FIR - McBride, Timothy IR - McBride T FIR - Stoll, Janis IR - Stoll J FIR - Capellan, Jahaira IR - Capellan J FIR - DiBitetto, Kristine IR - DiBitetto K FIR - Fiscella, Kevin IR - Fiscella K FIR - Williams, Geoffrey IR - Williams G FIR - Cherry, Lauren IR - Cherry L FIR - Drews, Kimberly IR - Drews K FIR - Gordon, Stewart IR - Gordon S FIR - Hall, Lindsay IR - Hall L FIR - Johnson, William IR - Johnson W FIR - Malek, Natalie IR - Malek N FIR - Murray, Peyton IR - Murray P FIR - Shao, Yaming IR - Shao Y FIR - Singletary, R Kenneth Jr IR - Singletary RK Jr FIR - Ullmer, Angelle IR - Ullmer A FIR - Zebrick, Ava IR - Zebrick A FIR - Hassink, Sandra IR - Hassink S FIR - Rogers, Victoria IR - Rogers V FIR - Salmon, Jeremiah IR - Salmon J EDAT- 2026/07/27 12:36 MHDA- 2026/10/05 17:31 PMCR- 2026/07/27 CRDT- 2026/07/27 11:35 PHST- 2026/10/05 17:31 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 11:35 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 2851911 [pii] AID - poi260043 [pii] AID - 10.1001/jamapediatrics.2026.3067 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Oct 1;180(10):1076-1084. doi: 10.1001/jamapediatrics.2026.3067. PMID- 42507151 OWN - NLM STAT- Publisher LR - 20260929 IS - 1432-1084 (Electronic) IS - 0938-7994 (Linking) DP - 2026 Jul 27 TI - Region-, zone-, and layer-specific knee cartilage T2 relaxation patterns in sports-active adolescents. LID - 10.1007/s00330-026-12765-4 [doi] AB - OBJECTIVES: This study aimed to investigate region-, zone-, and layer-specific differences in knee cartilage T2 relaxation times between sports-active adolescents and age- and sex-matched controls and to explore associations with training-related variables. MATERIALS AND METHODS: A color-coded T2 map was automatically produced from a sagittal multi-slice multi-echo T2 sequence obtained at 1.5-T MRI in 42 sports-active adolescents participating in football, basketball, or volleyball and in 42 matched controls. Cartilage was segmented manually in six regions, and each region was automatically subdivided into anterior, central, and posterior zones as well as superficial, intermediate, and deep layers (54 subregions per knee). T2 relaxation times were compared between groups, and multivariable regression analyses were performed to assess associations with training-related variables. Intraobserver reliability was evaluated using intraclass correlation coefficients (ICC). RESULTS: Sports-active adolescents showed significantly higher T2 values in the patellofemoral joint, lateral tibiofemoral compartment, and medial femoral condyle compared with controls (all p < 0.05). The physiological superficial-to-deep T2 gradient observed in controls appeared partially altered in sports-active adolescents. Zone-specific analysis revealed more frequent T2 elevations in posterior zones. Daily training duration and years of participation were independently associated with compartment-specific T2 alterations. Intraobserver agreement was good to excellent (ICC range: 0.80-0.97). CONCLUSION: Cartilage T2 alterations were mainly observed between sports-active adolescents and controls, with additional differences among sports disciplines, indicating sport-specific cartilage adaptations to repetitive mechanical loading. KEY POINTS: Question Do sports-active adolescents show region-, zone-, and layer-specific differences in knee cartilage T2 relaxation times compared with non-sports-active controls? Findings Sports-active adolescents exhibited higher T2 values predominantly in the patellofemoral joint, lateral tibiofemoral compartment, and medial femoral condyle, with posterior and depth-dependent changes associated with training exposure. Clinical relevance T2 mapping is an important imaging biomarker for detecting cartilage at risk in physically active adolescents before visible structural damage occurs. CI - (c) 2026. The Author(s), under exclusive licence to European Society of Radiology. FAU - Colak, Edis AU - Colak E AUID- ORCID: 0000-0001-5191-0491 AD - Department of Pediatric Radiology, University of Health Sciences, Izmir Faculty of Medicine, Dr. Behcet Uz Children's Training and Research Hospital, Izmir, Turkiye. drediscolak@gmail.com. AD - Department of Biophysics, Faculty of Medicine, Ege University, Izmir, Turkiye. drediscolak@gmail.com. FAU - Doganay, Ozkan AU - Doganay O AD - Department of Biophysics, Faculty of Medicine, Ege University, Izmir, Turkiye. FAU - Koska, Ilker Ozgur AU - Koska IO AD - Department of Pediatric Radiology, Acibadem Izmir Kent Hospital, Izmir, Turkiye. FAU - Celebiler, Isil AU - Celebiler I AD - Department of Pediatric Orthopedics, University of Health Sciences, Izmir Faculty of Medicine, Dr. Behcet Uz Children's Training and Research Hospital, Izmir, Turkiye. FAU - Orbatu, Dilek AU - Orbatu D AD - Department of Pediatrics, University of Health Sciences, Izmir Faculty of Medicine, Dr. Behcet Uz Children's Training and Research Hospital, Izmir, Turkiye. LA - eng PT - Journal Article DEP - 20260727 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 SB - IM CIN - Eur Radiol. 2026 Sep 29. doi: 10.1007/s00330-026-12948-z. PMID: 42809118 OTO - NOTNLM OT - Adolescent OT - Cartilage OT - Knee joint OT - Magnetic resonance imaging OT - Sports COIS- Compliance with ethical standards. Guarantor: The scientific guarantor of this publication is Ozkan Doganay. Conflict of interest: The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. Statistics and biometry: Edis Colak and Ozkan Doganay have significant statistical expertise. Informed consent: Written informed consent was waived by the Institutional Review Board. Ethical approval: Institutional Review Board approval was obtained (Protocol No. GOA-200). Study subjects or cohorts overlap: The study subjects or cohorts have not been previously reported. Methodology: Retrospective Cross-sectional study Observational Performed at one institution EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:36 CRDT- 2026/07/27 11:13 PHST- 2026/03/12 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/06/08 00:00 [revised] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 12:36 [medline] PHST- 2026/07/27 11:13 [entrez] AID - 10.1007/s00330-026-12765-4 [pii] AID - 10.1007/s00330-026-12765-4 [doi] PST - aheadofprint SO - Eur Radiol. 2026 Jul 27. doi: 10.1007/s00330-026-12765-4. PMID- 42507042 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 27 TI - The spatial heterogeneity of intra-pancreatic fat deposition in children and adolescents with obesity. LID - 614 [pii] LID - 10.1007/s00431-026-07283-w [doi] AB - Childhood obesity is associated with an increased risk of metabolic associated fatty liver disease (MAFLD) and intra-pancreatic fat deposition (IPFD). Recent studies in adults suggest that pancreatic fat distribution is heterogeneous and that fat deposition in different regions may have distinct metabolic implications. However, data on regional IPFD patterns and their association with insulin resistance in children with obesity remain limited. This study aimed to investigate the regional distribution of pancreatic fat and its association with insulin resistance in children and adolescents with obesity. This retrospective study included 231 children and adolescents with obesity (156 boys, 75 girls; age range 8-18 years). All participants underwent magnetic resonance imaging (MRI) using the qDixon technique to quantify fat fractions in the pancreatic head, body, and tail, as well as in the liver. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Statistical analyses included Spearman correlations, logistic regression, and receiver operating characteristic (ROC) curve analysis. The prevalence of high IPFD was higher in the pancreatic head than in the body and tail across all cutoff values (> 10%, > 15%, and > 20%) in both sexes (p < 0.01). Pancreatic head fat, but not body or tail fat, was significantly correlated with insulin levels and HOMA-IR (p < 0.01). In logistic regression models adjusted for confounders, pancreatic head fat (as a continuous variable and with a > 20% cutoff) was independently associated with high insulin (odds ratio (OR) = 1.02, 95% confidence interval (CI):1.002-1.043, and OR = 2.10, 95%CI: 1.00-4.47) and insulin resistance (OR = 1.02, 95% CI: 1.002-1.044; and OR = 2.31, 95% CI: 1.13-4.78, respectively). ROC analysis showed that pancreatic head fat had a significantly higher area under the curve (AUC = 0.65) for predicting insulin resistance than body, tail and liver fat (AUC = 0.60)(p = 0.02). In children and adolescents with obesity, the deposition of pancreatic fat is heterogeneous, with the greatest accumulation observed in the pancreatic head. Fat in the pancreatic head is independently associated with high insulin resistance, whereas fat in the body and tail is not. What is Known? * Obesity is associated with an increased risk of intra-pancreatic fat deposition (IPFD). * IPFD may be associated with metabolic risk. What is New? * This is the first study reporting the spatial heterogeneity of IPFD in children and adolescents with obesity. * Fat accumulation in the pancreatic head, but no in body and tail is associated with high level of insulin resistance. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Xiao, Hanfang AU - Xiao H AD - Department of Radiology, Shanghai Children's Hospital, Shanghai, 200062, China. AD - Department of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. FAU - Zhang, Huanhuan AU - Zhang H AD - Department of Radiology, Shanghai Children's Hospital, Shanghai, 200062, China. AD - Department of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. FAU - Yang, Hong AU - Yang H AD - Department of Radiology, Shanghai Children's Hospital, Shanghai, 200062, China. yanghongyh@sjtu.edu.cn. AD - Department of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. yanghongyh@sjtu.edu.cn. FAU - Li, Tingting AU - Li T AD - Department of Radiology, Shanghai Children's Hospital, Shanghai, 200062, China. litt@shchildren.com.cn. AD - Department of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. litt@shchildren.com.cn. FAU - Chen, Xiao AU - Chen X AD - Department of Radiology, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China. LA - eng GR - k2026yrc25/Peak Talent Program of Jiangsu Provincial Hospital of Chinese Medicine/ PT - Journal Article DEP - 20260727 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - Adolescent MH - *Insulin Resistance MH - *Pancreas/diagnostic imaging/pathology MH - Retrospective Studies MH - Magnetic Resonance Imaging MH - *Pediatric Obesity/complications MH - *Adipose Tissue/diagnostic imaging MH - ROC Curve MH - Logistic Models OTO - NOTNLM OT - Children and adolescents OT - Intra-Pancreatic fat deposition OT - Obesity OT - Spatial heterogeneity COIS- Declarations. Ethical approval and consent to participate: Ethics approval was obtained from Shanghai Children Hospital. The study was performed in accordance with the Declaration of Helsinki. The need for informed consent was waived by the Ethics Committee of Shanghai Children Hospital because of the retrospective nature of the study. Consent for publication: Not applicable. Competing interest: The authors have no conflicts of interest to declare that are relevant to the content of this article. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 CRDT- 2026/07/27 11:05 PHST- 2026/04/15 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/07/20 00:00 [revised] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 11:05 [entrez] AID - 10.1007/s00431-026-07283-w [pii] AID - 10.1007/s00431-026-07283-w [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 27;185(8):614. doi: 10.1007/s00431-026-07283-w. PMID- 42506838 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 7 DP - 2026 Jul 10 TI - Association Between Physical Activity and Mental Health in Primary School Children. LID - 10.3390/sports14070295 [doi] LID - 295 AB - Mental health during childhood is a major public health concern, and physical activity has been proposed as a modifiable behaviour associated with psychological well-being and emotional health. This study examined the associations between physical activity and mental health indicators, including psychological well-being, anxiety symptoms, and everyday stress, in primary school children. A cross-sectional study was conducted with 207 children from two schools in Jaen (Spain). Physical activity, psychological well-being, anxiety, and stress were assessed using validated questionnaires. Pearson correlations and multiple linear regression analyses adjusted for age, sex, and socioeconomic status were performed. Physical activity was positively associated with all dimensions of psychological well-being and with total psychological well-being (r = 0.182, p = 0.009). Significant inverse correlations were observed between physical activity and all anxiety dimensions, as well as total anxiety (r = -0.145, p = 0.037), although the association with total anxiety was not significant after adjustment (beta = -0.149, p = 0.112). Physical activity was also negatively associated with all stress dimensions and remained significantly associated with lower total stress after adjustment (beta = -0.253, p = 0.007). These findings indicate that higher levels of physical activity are associated with greater psychological well-being and lower everyday stress in primary school children. However, given the cross-sectional design, these associations should not be interpreted as causal relationships. Longitudinal studies are needed to clarify the directionality of these associations. FAU - Lendinez-Conejo, Raul AU - Lendinez-Conejo R AD - Faculty of Educational Sciences, University of Jaen, 23071 Jaen, Spain. FAU - Aibar-Almazan, Agustin AU - Aibar-Almazan A AUID- ORCID: 0000-0002-9386-9199 AD - Department of Health Sciences, Faculty of Health Sciences, University of Jaen, 35017 Jaen, Spain. FAU - Carcelen-Fraile, Maria Del Carmen AU - Carcelen-Fraile MDC AUID- ORCID: 0009-0000-9186-8865 AD - Department of Educational Sciences, Faculty of Social Sciences, University of Atlantico Medio, 35017 Las Palmas de Gran Canaria, Spain. AD - International Scientific Association on Innovation in Education and Health (ACIINES), 23007 Jaen, Spain. AD - International Network of Educational Law, 35017 Las Palmas de Gran Canaria, Spain. LA - eng PT - Journal Article DEP - 20260710 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13417498 OTO - NOTNLM OT - anxiety OT - childhood OT - physical activity OT - primary education OT - psychological well-being OT - stress COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/10 CRDT- 2026/07/27 09:44 PHST- 2026/06/06 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:44 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - sports14070295 [pii] AID - sports-14-00295 [pii] AID - 10.3390/sports14070295 [doi] PST - epublish SO - Sports (Basel). 2026 Jul 10;14(7):295. doi: 10.3390/sports14070295. PMID- 42506821 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 7 DP - 2026 Jul 3 TI - High-Intensity Functional Concurrent Training for Physical Fitness, Body Composition, and Psychological Outcomes in Schoolchildren: Protocol for a Randomized Controlled Trial. LID - 10.3390/sports14070279 [doi] LID - 279 AB - High-intensity functional concurrent training (HIFCT) has emerged as a form of training characterized by constantly varied functional movements adapted to individual fitness levels. Previous studies have reported positive effects on muscular strength, cardiorespiratory fitness, body composition, and psychological well-being; however, evidence regarding HIFCT interventions in school-aged children remains limited. Therefore, the aim of the present study protocol is to evaluate the effects of an 8-week HIFCT programme on muscular strength, cardiorespiratory fitness, body composition, anxiety, stress, and self-esteem in children aged 10-12 years. Physical fitness, anthropometric variables, and psychological outcomes will be assessed before and after the intervention using validated field-based tests and questionnaires. This study may provide novel evidence regarding the feasibility, safety, and potential effects of HIFCT programmes in the school setting. The study protocol was registered at ClinicalTrials.gov (NCT07552844) and approved by the Cordoba Research Ethics Committee (IMIBIC, Cordoba, Spain; protocol code SICEIA-2025-000408). FAU - Duran-Lopez, Natalia AU - Duran-Lopez N AUID- ORCID: 0009-0008-5874-4519 AD - Ministry of Educational Development and Vocational Training, Regional Government of Andalusia, 41092 Sevilla, Spain. AD - Department of Psychology, Faculty of Educational Sciences and Psychology, University of Cordoba, 14004 Cordoba, Spain. FAU - Gomez-Garcia, Carlos AU - Gomez-Garcia C AUID- ORCID: 0009-0004-2735-2230 AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. FAU - Ranchal-Sanchez, Antonio AU - Ranchal-Sanchez A AUID- ORCID: 0000-0002-8655-8878 AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain. AD - Department of Nursing, Pharmacology and Physiotherapy, Faculty of Medicine and Nursing, University of Cordoba, 14004 Cordoba, Spain. FAU - Lucena-Jurado, Valentina AU - Lucena-Jurado V AUID- ORCID: 0000-0002-7011-6661 AD - Department of Psychology, Faculty of Educational Sciences and Psychology, University of Cordoba, 14004 Cordoba, Spain. FAU - Moyano-Ortega, Victoria AU - Moyano-Ortega V AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. FAU - Lara-Barahona Ostos, Ana AU - Lara-Barahona Ostos A AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AUID- ORCID: 0000-0002-0198-2793 AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain. AD - CIBERobn Physiopathology of Obesity and Nutrition, Centre of Biomedical Research Network, Institute of Health Carlos III, 28029 Madrid, Spain. LA - eng SI - ClinicalTrials.gov/NCT07552844 GR - University of Cordoba OTC Transfer Contract No. 12021050/University of Cordoba/ PT - Journal Article DEP - 20260703 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13417676 OTO - NOTNLM OT - high-intensity functional concurrent training OT - physical fitness OT - psychological health OT - schoolchildren COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/03 CRDT- 2026/07/27 09:44 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:44 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - sports14070279 [pii] AID - sports-14-00279 [pii] AID - 10.3390/sports14070279 [doi] PST - epublish SO - Sports (Basel). 2026 Jul 3;14(7):279. doi: 10.3390/sports14070279. PMID- 42506391 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2218-1989 (Print) IS - 2218-1989 (Electronic) IS - 2218-1989 (Linking) VI - 16 IP - 7 DP - 2026 Jun 23 TI - Metabolic Responses to Exercise and Nutritional Strategies in Type 1 Diabetes Using Automated Insulin Delivery Systems: A Narrative Review. LID - 10.3390/metabo16070437 [doi] LID - 437 AB - BACKGROUND/OBJECTIVES: Automated insulin delivery (AID) systems have improved the management of type 1 diabetes (T1D), but exercise and nutrition remain challenging because they rapidly alter glucose flux, substrate oxidation, hepatic glucose output, insulin requirements, and fuel availability. This narrative review aimed to synthesize current evidence on the interaction between AID systems, physical activity, and nutritional strategies from a metabolism-oriented perspective. METHODS: A narrative bibliographic approach was used to integrate evidence from clinical trials, observational studies, technical studies, consensus statements, and reviews involving people with T1D across different life stages, including pediatric, adolescent, adult, and pregnancy-related contexts, when available. The review focused on AID systems, exercise physiology, nutritional strategies, meal announcement, bolus adjustment, dual-hormone systems, metabolic biomarkers, and emerging metabolomic approaches. RESULTS: AID systems generally improve time in range and reduce hypoglycemia across several user groups, although most exercise- and nutrition-specific evidence comes from adult and pediatric/adolescent cohorts rather than pregnancy-specific exercise studies. Exercise-related glucose responses remain highly dependent on user input, exercise modality, insulin on board, meal timing, and metabolic state. Planned exercise announcement, prandial bolus reduction before postprandial activity, and individualized carbohydrate intake remain key strategies. Biomarkers such as lactate, ketone bodies, non-esterified fatty acids, and counter-regulatory hormones may help explain interindividual variability and support future personalization. CONCLUSIONS: Nutrition and exercise management in AID users should be interpreted as a dynamic metabolic interface among exogenous insulin, endogenous counter-regulation, substrate availability, and algorithmic control. Emerging approaches, including activity sensors, adaptive algorithms, dual-hormone systems, digital twins, and metabolomics-informed personalization, may improve safety and reduce user burden, but several remain exploratory and require further validation in diverse free-living conditions. FAU - Victoria-Montesinos, Desiree AU - Victoria-Montesinos D AUID- ORCID: 0000-0003-3968-9477 AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Llopis-Alonso, Inmaculada AU - Llopis-Alonso I AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Garcia-Munoz, Ana Maria AU - Garcia-Munoz AM AUID- ORCID: 0000-0002-1021-5385 AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Mercader-Ros, Maria Teresa AU - Mercader-Ros MT AUID- ORCID: 0000-0001-8194-0763 AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, 30107 Murcia, Spain. LA - eng PT - Journal Article PT - Review DEP - 20260623 PL - Switzerland TA - Metabolites JT - Metabolites JID - 101578790 PMC - PMC13413731 OTO - NOTNLM OT - artificial pancreas OT - automated insulin delivery OT - carbohydrate counting OT - continuous glucose monitoring OT - exercise metabolism OT - hybrid closed loop OT - metabolic biomarkers OT - metabolomics OT - nutrition OT - physical activity OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/06/23 CRDT- 2026/07/27 09:34 PHST- 2026/05/15 00:00 [received] PHST- 2026/06/17 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:34 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - metabo16070437 [pii] AID - metabolites-16-00437 [pii] AID - 10.3390/metabo16070437 [doi] PST - epublish SO - Metabolites. 2026 Jun 23;16(7):437. doi: 10.3390/metabo16070437. PMID- 42506345 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 3 DP - 2026 Jul 6 TI - Emotional Eating and Its Associations with the Prevalence of Depression and Anxiety Symptoms in University Students: A Cross-Sectional Study. LID - 10.3390/medsci14030376 [doi] LID - 376 AB - Background/Objectives: Emotional eating (EE) is an emerging public health concern among university students, a population exposed to heightened academic demands, psychosocial stressors, and lifestyle changes that may promote maladaptive coping behaviors. EE has been linked to psychological distress, particularly depressive and anxiety symptoms, as well as sociodemographic, lifestyle, and anthropometric factors; however, findings remain heterogeneous and insufficiently integrated within comprehensive analytical frameworks. This study aimed to examine the association between EE and depressive and anxiety symptoms in university students, while assessing the independent contributions of sociodemographic, academic, lifestyle, and anthropometric determinants. Methods: A cross-sectional survey was performed among 1279 university students from 10 regions in Greece. Sociodemographic, academic, lifestyle, and anthropometric data were collected using validated instruments and standardized procedures. Depressive and anxiety symptoms were assessed by the use of the Beck Depression Inventory-II (BDI-II) and the six-item State-Trait Anxiety Inventory (STAI-6), respectively. EE was evaluated utilizing the EE subscale of the Three-Factor Eating Questionnaire-Revised 18 (TFEQ-R18). Multivariable ordinal logistic regression models were applied to examine independent associations. Results: In fully adjusted models, depressive and anxiety symptoms were the strongest correlates of higher EE levels, each associated with more than twofold increased odds. Female sex, Greek nationality, rural residence, enrollment in biomedical sciences, later academic years, and regular smoking were also positively associated with EE. Higher physical activity was inversely associated with EE levels. Overweight, obesity, and increased waist circumference and waist-to-hip ratio were consistently linked to higher EE, with several associations exceeding twofold increased odds. Conclusions: EE in university students is strongly associated with psychological distress and clusters with adverse lifestyle and anthropometric characteristics. These findings support the need for integrated interventions targeting mental health, lifestyle behaviors, and obesity-related risk factors. Longitudinal studies are warranted to clarify causal pathways and underlying mechanisms. FAU - Alexatou, Olga AU - Alexatou O AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Papadopoulou, Sousana K AU - Papadopoulou SK AUID- ORCID: 0000-0002-6408-6128 AD - Department of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Angelakou, Exakousti-Petroula AU - Angelakou EP AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Migdanis, Athanasios AU - Migdanis A AD - Laboratory of Clinical Nutrition and Dietetics (CND-Lab), Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece. FAU - Louka, Aikaterini AU - Louka A AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Migdanis, Ioannis AU - Migdanis I AD - Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece. AD - Oncology Clinic and Hemodialysis Unit, "E. Patsidis" Health Group, Department of Clinical Nutrition, 41335 Larissa, Greece. FAU - Mentzelou, Maria AU - Mentzelou M AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Koimtsidis, Theodosios AU - Koimtsidis T AD - Department of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Psara, Evmorfia AU - Psara E AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Giaginis, Constantinos AU - Giaginis C AUID- ORCID: 0000-0003-2878-4831 AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. LA - eng PT - Journal Article DEP - 20260706 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Emotional Eating MH - Female MH - *Students/psychology MH - Cross-Sectional Studies MH - Universities MH - *Depression/epidemiology/psychology MH - Male MH - *Anxiety/epidemiology/psychology MH - Young Adult MH - Prevalence MH - Greece/epidemiology MH - Adult MH - Adolescent MH - Surveys and Questionnaires PMC - PMC13414101 OTO - NOTNLM OT - anxiety OT - depression OT - emotional eating OT - mental health OT - psychological distress OT - university students COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/06 CRDT- 2026/07/27 09:34 PHST- 2026/06/22 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:34 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - medsci14030376 [pii] AID - medsci-14-00376 [pii] AID - 10.3390/medsci14030376 [doi] PST - epublish SO - Med Sci (Basel). 2026 Jul 6;14(3):376. doi: 10.3390/medsci14030376. PMID- 42505707 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2304-6767 (Electronic) IS - 2304-6767 (Linking) VI - 14 IP - 7 DP - 2026 Jul 2 TI - Who Gets Dental Caries? A Comprehensive Review. LID - 10.3390/dj14070400 [doi] LID - 400 AB - Dental caries is the world's most common non-communicable disease with a complex etiology including social, behavioral, medical, biological and economical elements. The distribution among populations and age groups is skewed, which calls for validated clinical tools to identify those with increased caries risk. The aim of this article was therefore to review risk factors for caries development in children, based on global prospective birth cohorts, genetic proceedings and data from validated risk assessment tools. The genetic elements involve four main categories comprising enamel quality, salivary composition, dental biofilm function and taste preferences. Recent studies suggest that genes may account for 35-55% of the variation in caries scores in the young permanent dentition. Prospective birth cohorts have pointed out poverty, socioeconomic level, early introduction and excessive sugar intake as significant factors for a child's dental caries trajectory up into adulthood. Moreover, prolonged breastfeeding, child obesity and maternal oral conditions are linked to the caries burden later in life. In the clinic, the strongest predictors are past caries history and selected behavioral and social factors. The performance of the validated caries risk assessment models is far from perfect, but still acceptable in terms of reliability during childhood. These tools are the best clinical practice since they add objectivity, consistency and documentation to the clinical routines. In addition, the dental staff has the advantage of using the outcome of the assessment for a structured risk communication with the caregivers. The protocol should also form the basis for a personalized intervention program addressing the entire family, with particular focus on maternal oral health and sugar reduction. FAU - Twetman, Svante AU - Twetman S AUID- ORCID: 0000-0002-0199-9210 AD - Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark. AD - Department of Paediatric Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Papaioannou, William AU - Papaioannou W AUID- ORCID: 0000-0001-5146-4399 AD - Department of Preventive and Community Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Gizani, Sotiria AU - Gizani S AD - Department of Paediatric Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece. LA - eng PT - Journal Article PT - Review DEP - 20260702 PL - Switzerland TA - Dent J (Basel) JT - Dentistry journal JID - 101716125 PMC - PMC13407877 OTO - NOTNLM OT - caries trajectory OT - children OT - heredity OT - risk assessment OT - socio-economy OT - sugars COIS- The authors have no conflicts of interest to declare. This paper was entirely financed by the authors' academic institutions. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/02 CRDT- 2026/07/27 09:25 PHST- 2026/05/05 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:25 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - dj14070400 [pii] AID - dentistry-14-00400 [pii] AID - 10.3390/dj14070400 [doi] PST - epublish SO - Dent J (Basel). 2026 Jul 2;14(7):400. doi: 10.3390/dj14070400. PMID- 42504412 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 1099-0496 (Electronic) IS - 8755-6863 (Print) IS - 1099-0496 (Linking) VI - 61 IP - 8 DP - 2026 Aug TI - Functional Exercise Capacity and Exploratory ICF-Aligned Interpretation of the Incremental Shuttle Walk Test in Children With Asthma. PG - e71734 LID - 10.1002/ppul.71734 [doi] LID - e71734 AB - BACKGROUND: Children with asthma may experience functional exercise limitations that are not fully reflected by resting lung function or conventional clinical assessments. Field-based exercise tests provide complementary information regarding functional capacity, and the International Classification of Functioning, Disability and Health (ICF) offers a biopsychosocial framework to contextualize activity limitations. However, the integration of objective exercise performance with ICF-aligned interpretation in pediatric asthma remains limited. OBJECTIVE: To interpret functional exercise capacity in children with asthma using Incremental Shuttle Walk Test (ISWT) performance through an exploratory operational framework conceptually aligned with ICF activity qualifiers and to examine its association with lung function, asthma control, quality of life, and demographic characteristics. METHODS: In this cross-sectional study, 39 children with asthma (mean age 8.6 +/- 2.3 years) underwent spirometry, completed the Asthma Control Questionnaire (ACQ-6) and the Pediatric Asthma Quality of Life Questionnaire (PAQLQ), and performed the ISWT. Functional exercise capacity was expressed as a percentage of predicted ISWT distance and interpreted using an exploratory operational framework conceptually aligned with generic ICF activity qualifiers, generating two categories of activity limitation (mild/moderate and severe). RESULTS: Resting lung function was relatively preserved (mean FEV(1) 82.0 +/- 16.4% predicted), whereas functional exercise capacity was markedly reduced (mean ISWT 41.4 +/- 18.7% predicted). Based on the exploratory ICF-aligned framework, 72% of participants were categorized as having severe activity limitation. Children with severe limitations walked significantly shorter distances than those with mild/moderate limitations (32.0 +/- 11.5% vs. 65.3 +/- 10.1% predicted; p < 0.001), with a very large effect size. Spirometric indices, asthma control, and quality of life scores did not differ between functional categories. ISWT performance was not correlated with lung function, asthma control, or quality of life and demonstrated a negative association with age. CONCLUSION: Children with asthma may present substantial functional exercise limitations despite relatively preserved lung function and similar levels of asthma control and quality of life. The exploratory operational alignment of ISWT performance with generic ICF activity qualifiers may provide a clinically useful framework to support interpretation of activity limitations not captured by conventional assessments. However, this approach should be interpreted cautiously and requires future validation before broader clinical application. CI - (c) 2026 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC. FAU - Cavalcante de Souza, Danilo Rufino AU - Cavalcante de Souza DR AD - Universidade de Sao Paulo - FMUSP, Sao Paulo, Brazil. FAU - Costa, Ivan Peres AU - Costa IP AD - Universidade Nove de Julho- UNINOVE, Sao Paulo, Brazil. FAU - Teixeira de Carvalho, Etiene Farah AU - Teixeira de Carvalho EF AUID- ORCID: 0000-0002-5765-7228 AD - Universidade Nove de Julho- UNINOVE, Sao Paulo, Brazil. FAU - Costa, Dirceu AU - Costa D AD - Universidade Nove de Julho- UNINOVE, Sao Paulo, Brazil. FAU - de Freitas Dantas Gomes, Evelim Leal AU - de Freitas Dantas Gomes EL AD - Universidade de Sao Paulo - FMUSP, Sao Paulo, Brazil. LA - eng PT - Journal Article PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - Child MH - *Asthma/physiopathology MH - Female MH - Cross-Sectional Studies MH - Male MH - Quality of Life MH - *Exercise Tolerance/physiology MH - *Walk Test/methods MH - Spirometry MH - Surveys and Questionnaires MH - Adolescent MH - Disability Evaluation PMC - PMC13402909 OTO - NOTNLM OT - Incremental Shuttle Walk Test OT - International Classification of Functioning OT - activity limitation OT - functional exercise capacity OT - pediatric asthma COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 06:34 MHDA- 2026/07/27 06:35 PMCR- 2026/07/27 CRDT- 2026/07/27 03:43 PHST- 2026/05/11 00:00 [revised] PHST- 2026/01/05 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/27 06:35 [medline] PHST- 2026/07/27 06:34 [pubmed] PHST- 2026/07/27 03:43 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - PPUL71734 [pii] AID - 10.1002/ppul.71734 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 Aug;61(8):e71734. doi: 10.1002/ppul.71734. PMID- 42504013 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 1541-4337 (Electronic) IS - 1541-4337 (Linking) VI - 25 IP - 4 DP - 2026 Jul TI - Special Milk and Synthetic Biology: A Dual-Perspective Review of Ingredient Substitutions in Breast-Milk-Simulated Infant Formula. PG - e70572 LID - 10.1111/1541-4337.70572 [doi] LID - e70572 AB - Breast milk (BM) serves as the gold standard for infant nutrition, yet conventional cow's milk-based infant formulas (IF) fail to adequately replicate its structural and functional complexity. This review critically examines two complementary paradigms, specialty milk utilization and synthetic biology-enabled precision manufacturing, as transformative strategies for developing biomimetic IF ingredients. Specialty milks, including goat milk, camel milk, donkey milk, buffalo milk, and yak milk, exhibit compositional proximity to BM in specific dimensions, including digestibility, sn-2 fatty acid profiles, and fat globule size distribution. Synthetic biology platforms have achieved notable industrial-scale successes, particularly in producing 2'-fucosyllactose and recombinant lactoferrin. However, significant knowledge gaps persist: the reconstruction of complex multi-site phosphorylation, the high-fidelity assembly of triple-layer milk fat globule membranes, and cost-effective large-scale production remain unresolved challenges. Critically, most studies focus on single components rather than integrated formula systems, and robust clinical validation is lacking. This review argues that the convergence of specialty milk matrices with precision-fermented bioactives represents a paradigm shift from compositional to structure-function biomimicry. Priority research areas include multi-omics-based integration strategies, harmonized regulatory frameworks, and well-designed clinical trials to establish functional equivalence. Addressing these gaps will be essential for developing next-generation IF that more closely emulates the functional complexity of BM. CI - (c) 2026 Institute of Food Technologists(R). FAU - Zhang, Chao AU - Zhang C AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - School of Food Science and Technology, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. FAU - Qiu, Yu AU - Qiu Y AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - School of Food Science and Technology, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. FAU - Mao, Qingli AU - Mao Q AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - School of Food Science and Technology, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. FAU - Wu, Yong AU - Wu Y AUID- ORCID: 0000-0001-9840-940X AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. AD - Sino-German Joint Research Institute, Nanchang University, Nanchang, China. FAU - Meng, Xuanyi AU - Meng X AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. AD - Sino-German Joint Research Institute, Nanchang University, Nanchang, China. FAU - Zheng, Shuangyan AU - Zheng S AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. AD - Sino-German Joint Research Institute, Nanchang University, Nanchang, China. FAU - Chen, Hongbing AU - Chen H AUID- ORCID: 0000-0002-4845-383X AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. AD - Sino-German Joint Research Institute, Nanchang University, Nanchang, China. FAU - Li, Xin AU - Li X AUID- ORCID: 0000-0002-9466-2659 AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - School of Food Science and Technology, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. LA - eng GR - 2026YFE0103600/National Key R&D Program of China/ PT - Journal Article PT - Review PL - United States TA - Compr Rev Food Sci Food Saf JT - Comprehensive reviews in food science and food safety JID - 101305205 SB - IM MH - Humans MH - *Infant Formula/chemistry MH - *Synthetic Biology MH - Animals MH - *Milk, Human/chemistry MH - *Milk/chemistry MH - Infant PMC - PMC13402779 OTO - NOTNLM OT - breast milk biomimicry OT - human milk oligosaccharides OT - infant formula OT - specialty milk OT - synthetic biology COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 06:34 MHDA- 2026/07/27 06:35 PMCR- 2026/07/27 CRDT- 2026/07/27 01:43 PHST- 2026/06/18 00:00 [revised] PHST- 2026/04/23 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/27 06:35 [medline] PHST- 2026/07/27 06:34 [pubmed] PHST- 2026/07/27 01:43 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - CRF370572 [pii] AID - 10.1111/1541-4337.70572 [doi] PST - ppublish SO - Compr Rev Food Sci Food Saf. 2026 Jul;25(4):e70572. doi: 10.1111/1541-4337.70572. PMID- 42502951 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260910 IS - 1099-1751 (Electronic) IS - 0749-6753 (Print) IS - 0749-6753 (Linking) VI - 41 IP - 5 DP - 2026 Sep TI - Understanding How Multisectoral Programs and Policies Across Systems Can Be Leveraged to Improve Maternal, Infant, and Child Nutrition in Guinea. PG - 1071-1084 LID - 10.1002/hpm.70105 [doi] AB - OBJECTIVE: To understand how current programmes and policies can be leveraged to improve maternal, infant, and young child nutrition outcomes (MIYCN) in Guinea. DATA COLLECTION METHODS: Study design. This study is part of a larger multiphase mixed methods study design. THEORETICAL FRAMEWORK: A systems framework developed by the United Nations Children's Fund (UNICEF) and an implementation science framework were used to guide this research. Phase 1. An in-depth literature review of current programme and policy documents (2019-2022) targeting MIYCN through the water, sanitation, and hygiene (WASH), health, food, and social protection systems in Guinea was conducted. Phase 2. Semi-structured interviews with stakeholders (n = 20) from each system were completed to explore stakeholders' knowledge related to pertinent programs and policies. Phase 3. Validation of findings was conducted using member checking. DATA ANALYSIS METHODS: Grey literature documents and interview findings were analysed using content analysis guided by the systems framework and implementation science framework, respectively. RESULTS: Policy documents across systems were all multisectoral and more than half (27/32) of evidence-based programme modalities across systems were included in policies. Most (28/32) evidence-based programme modalities were also being implemented in Guinea. Stakeholder interview findings revealed that programme implementation was the most salient barrier to operationalising evidence-based programme modalities. CONCLUSION: Findings from our study indicate that policy and programme frameworks are strong but improved financial planning and vertical and horizontal programme planning may create a stronger enabling environment to support MIYCN in Guinea. CI - (c) 2026 The Author(s). The International Journal of Health Planning and Management published by John Wiley & Sons Ltd. FAU - Schwendler, Teresa R AU - Schwendler TR AUID- ORCID: 0000-0002-0822-4880 AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Sankhon, Ramatou Hermine AU - Sankhon RH AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Jensen, Leif AU - Jensen L AD - Department of Agricultural Economics, Sociology, and Education, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Fofana, Mohamed L AU - Fofana ML AD - Helen Keller Intl, Conakry, Guinea. FAU - Daffe, Mamady AU - Daffe M AD - Ministere de la Sante et de l'Hygiene Publique, Conakry, Guinea. FAU - Camara, Facely AU - Camara F AD - Ministere de la Sante et de l'Hygiene Publique, Conakry, Guinea. FAU - Zoma, Ramakwende AU - Zoma R AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Balde, Ibrahima AU - Balde I AD - Centre de Recherche et de Formation en Infectiologie de Guinee, Conakry, Guinea. FAU - Kodish, Stephen R AU - Kodish SR AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Department of Biobehavioral Health, The Pennsylvania State University, State College, Pennsylvania, USA. LA - eng GR - Fulbright U.S. Student Program/ GR - Beard Program Endowment/ GR - Mary Frances Picciano Endowment Award/ GR - Nutritional Sciences Departmental Endowment Award/ GR - College of Health and Human Development Endowment Grant/ GR - Ann Atherton Hertzler Endowment/ PT - Journal Article PT - Review DEP - 20260726 PL - England TA - Int J Health Plann Manage JT - The International journal of health planning and management JID - 8605825 SB - IM MH - Humans MH - Guinea MH - Female MH - Infant MH - *Health Policy MH - Interviews as Topic MH - Child, Preschool PMC - PMC13551520 OTO - NOTNLM OT - infant and young child OT - nutrition OT - nutrition policy OT - pregnancy COIS- The authors declare no conflicts of interest. EDAT- 2026/07/26 13:21 MHDA- 2026/09/08 12:33 PMCR- 2026/09/08 CRDT- 2026/07/26 08:13 PHST- 2026/04/04 00:00 [revised] PHST- 2024/08/04 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/09/08 12:33 [medline] PHST- 2026/07/26 13:21 [pubmed] PHST- 2026/07/26 08:13 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - HPM70105 [pii] AID - 10.1002/hpm.70105 [doi] PST - ppublish SO - Int J Health Plann Manage. 2026 Sep;41(5):1071-1084. doi: 10.1002/hpm.70105. Epub 2026 Jul 26. PMID- 42502880 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20260929 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) VI - 41 IP - 5 DP - 2026 Oct TI - Evaluation of the reliability of current neonatal malnutrition indicators in diagnosis: An analysis of a retrospective cohort. PG - 1445-1456 LID - 10.1002/ncp.70157 [doi] AB - BACKGROUND: Proposed diagnostic criteria for neonatal malnutrition have not been validated. The objective of this study was to evaluate the reliability of the 2018 neonatal malnutrition criteria for identifying malnutrition in preterm infants. METHODS: A retrospective study of premature infants admitted to a level III neonatal intensive care unit from 2013 to 2022 was performed. Malnutrition diagnoses were assigned using each indicator. Weight and linear growth velocities were defined using the preferred approach (maintaining z-score on Fenton growth chart) and generalized growth goals (weight: 15-20 g/kg/day for infants <2000 g, 20-30 g/day for infants >/=2000 g, length: 1 cm/week). Kappa (k) values assessed the inter-indicator reliability of the full criteria and the inter-indicator and intra-indicator reliability of individual malnutrition criteria. Acceptable reliability was defined as k > 0.8. RESULTS: This study included 2305 infants. The 2018 neonatal malnutrition criteria had poor inter-indicator reliability for diagnosis in the first 2 weeks of life (k = 0.054) and after the first 2 weeks (k = 0.087). Inter-indicator reliability varied but was better among growth-based indicators. Intra-indicator reliability was strong for weight gain velocity definitions (k values ranging from 0.86 to 0.94), but poor for linear growth definitions (k = 0.12). CONCLUSION: Proposed neonatal malnutrition criteria have poor reliability when all indicators are used and limited reliability at the individual indicator level. Utilization of generalized weight gain goals may be appropriate for malnutrition diagnosis, but the generalized linear growth goal of 1 cm/week is not. Differing patterns in malnutrition diagnoses should be investigated for clinical significance. Redevelopment of current indicators is likely warranted. CI - (c) 2026 American Society for Parenteral and Enteral Nutrition. FAU - Merlino Barr, Stephanie AU - Merlino Barr S AUID- ORCID: 0000-0002-0125-5684 AD - MetroHealth Medical Center, Cleveland, Ohio, USA. FAU - Hand, Rosa K AU - Hand RK AD - Case Western Reserve University, Cleveland, Ohio, USA. FAU - Collin, Marc AU - Collin M AD - MetroHealth Medical Center, Cleveland, Ohio, USA. FAU - Love, Thomas E AU - Love TE AD - MetroHealth Medical Center, Cleveland, Ohio, USA. AD - Case Western Reserve University, Cleveland, Ohio, USA. FAU - Groh-Wargo, Sharon AU - Groh-Wargo S AD - MetroHealth Medical Center, Cleveland, Ohio, USA. AD - Case Western Reserve University, Cleveland, Ohio, USA. LA - eng GR - Stephanie Merlino Barr has received compensation for creating and presenting academic materials for Abbott Nutrition Health Institute, Reckitt/Mead Johnson, and Nutricia. Dr. Groh-Wargo is on the speaker's bureau of Abbott Nutrition. Drs. Hand, Collin, and Love have no financial disclosures/ PT - Evaluation Study PT - Journal Article DEP - 20260726 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - Retrospective Studies MH - Infant, Newborn MH - Reproducibility of Results MH - *Infant Nutrition Disorders/diagnosis MH - Female MH - Infant, Premature/growth & development MH - Male MH - Intensive Care Units, Neonatal MH - *Nutrition Assessment OTO - NOTNLM OT - malnutrition OT - neonatal OT - premature infants OT - reliability OT - weight gain EDAT- 2026/07/26 06:42 MHDA- 2026/09/29 12:27 CRDT- 2026/07/26 04:12 PHST- 2026/06/04 00:00 [revised] PHST- 2025/09/22 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/09/29 12:27 [medline] PHST- 2026/07/26 06:42 [pubmed] PHST- 2026/07/26 04:12 [entrez] AID - 10.1002/ncp.70157 [doi] PST - ppublish SO - Nutr Clin Pract. 2026 Oct;41(5):1445-1456. doi: 10.1002/ncp.70157. Epub 2026 Jul 26. PMID- 42502744 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260726 LR - 20260813 IS - 2211-3355 (Print) IS - 2211-3355 (Electronic) IS - 2211-3355 (Linking) VI - 69 DP - 2026 Sep TI - Obesity and severe obesity prevalence among youth aged 2-17 in Minnesota, 2020-2025. PG - 103576 LID - 10.1016/j.pmedr.2026.103576 [doi] LID - 103576 AB - OBJECTIVE: Existing sources for monitoring pediatric obesity prevalence are limited by delayed data availability and insufficient granularity for small-area estimates. We used data from the Minnesota Electronic Health Record Consortium's Health Trends Across Communities (HTAC) project to estimate obesity and severe obesity prevalence among Minnesota youth. METHODS: In serial cross-sectional analyses, HTAC data were obtained from 11 health systems in Minnesota. Patients aged 2-17 years with a valid body mass index (BMI) measurement at a participating health system from 2020 to 2025 were included. Obesity was defined as BMI >/=95th percentile for age and sex, and severe obesity as BMI >/=120% of the 95th percentile. Results are reported as prevalence estimates stratified by sociodemographic characteristics. RESULTS: Among 486,744 youth with BMI measured in 2025, 80,360 (16.5%, 95% CI: 16.4, 16.6) had obesity and 25,776 (5.3%, 95% CI: 5.2, 5.4) had severe obesity. Prevalence was higher among youth 12-17 years, males, and youth who were American Indian, Black, or Hispanic, and among those living in small towns or rural communities and in areas of high social vulnerability. CONCLUSIONS: HTAC data provide timely pediatric obesity and severe obesity prevalence estimates in Minnesota and may serve as a model for other regions. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Patnoe, Samuel T AU - Patnoe ST AD - HealthPartners Institute, Minneapolis, MN, United States of America. FAU - Vazquez-Benitez, Gabriela AU - Vazquez-Benitez G AD - HealthPartners Institute, Minneapolis, MN, United States of America. FAU - Bergmann, Kelly R AU - Bergmann KR AD - Children's Minnesota, Minneapolis, MN, United States of America. FAU - Buchanan, Gretchen J AU - Buchanan GJ AD - Hennepin Healthcare, Minneapolis, MN, United States of America. FAU - Arenson, Michael AU - Arenson M AD - Hennepin Healthcare, Minneapolis, MN, United States of America. FAU - Martins, Summer L AU - Martins SL AD - Allina Health, Minneapolis, MN, United States of America. FAU - Winkelman, Tyler N A AU - Winkelman TNA AD - Hennepin Healthcare, Minneapolis, MN, United States of America. FAU - Kharbanda, Elyse O AU - Kharbanda EO AD - HealthPartners Institute, Minneapolis, MN, United States of America. LA - eng GR - UM1 TR004405/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260716 PL - United States TA - Prev Med Rep JT - Preventive medicine reports JID - 101643766 PMC - PMC13400293 OTO - NOTNLM OT - Electronic health records OT - Pediatric obesity OT - Population health OT - Prevalence OT - Severe obesity COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Gabriela Vazquez-Benitez reports research support from AbbVie, unrelated to the current study. The remaining authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/26 06:42 MHDA- 2026/07/26 06:43 PMCR- 2026/07/16 CRDT- 2026/07/26 04:09 PHST- 2026/04/29 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/26 06:43 [medline] PHST- 2026/07/26 06:42 [pubmed] PHST- 2026/07/26 04:09 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - S2211-3355(26)00204-4 [pii] AID - 103576 [pii] AID - 10.1016/j.pmedr.2026.103576 [doi] PST - epublish SO - Prev Med Rep. 2026 Jul 16;69:103576. doi: 10.1016/j.pmedr.2026.103576. eCollection 2026 Sep. PMID- 42502626 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260726 LR - 20260813 IS - 1728-869X (Print) IS - 2226-5104 (Electronic) IS - 1728-869X (Linking) VI - 24 IP - 4 DP - 2026 Oct TI - A school-level randomized preliminary study of in-classroom physical activity breaks among fifth graders. PG - 200498 LID - 10.1016/j.jesf.2026.200498 [doi] LID - 200498 AB - BACKGROUND: In-classroom physical activity breaks (IcPABs) are a pragmatic strategy to reduce sedentary time and promote movement during instructional lessons. However, evidence from primary schools operating within a high-stakes examination-focused education system, where academic achievement in national assessments is prioritized in classroom instruction is limited from low- and middle-income countries. This study aimed to examine the preliminary effects and feasibility of a teacher-led, in-classroom physical activity break intervention on school-time movement behaviors, academic performance, and selected health-related outcomes among Sri Lankan fifth-grade students. METHODS: 220 students from two government primary schools in Sri Lanka (mean (age) = 9.48 years +/- 0.5, 61% male) were randomly assigned to (1) an intervention group (n = 100): attending thrice-a-day, 5-min IcPAB for 12 weeks; and (2) a control group (n = 120). Pre- and post-intervention assessments were conducted for academic achievement (standardized tests), movement behaviors (ActiGraph Gt3X), body-mass-index (anthropometric data), aerobic fitness (20m shuttle run test), and perceived stress (PSQ8-11). Generalized Linear Mixed Models were used for statistical analyses at exploratory level. Feasibility was evaluated using teacher logs, classroom observations and process evaluation records. RESULTS: Significant group-by-time effects were observed for reading performance (82.2 +/- 13.9 to 88.0 +/- 12.9 vs 76.7 +/- 10.5 to 77.6 +/- 13.0 in controls), MVPA (27.2 +/- 9.4 to 44.3 +/- 9.9 vs 31.1 +/- 8.4 to 24.3 +/- 9.4), step count (5609 +/- 1019 to 7769 +/- 1339 vs 7998 +/- 1023 to 3942 +/- 1046), and sedentary school time (1490.7 +/- 53.1 to 1475.4 +/- 59.4 vs 1485.0 +/- 22.9 to 1655.1 +/- 40.8). The study fidelity assessment confirmed 1 to 4 times daily activity implementation. The process evaluation indicated satisfactory participant engagement and smooth implementation, suggesting the study was conducted as intended. CONCLUSION: This school level randomized preliminary study observed improvements in reading performance, while effects on mathematics and health-related outcomes were limited. However, in-classroom physical activity breaks were feasible to implement in an academically intensive Sri Lankan primary school context and were associated with favorable changes in school-time movement behaviors. Yet larger multi-school trials are expected to confirm these findings. CI - (c) 2026 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier B.V. FAU - Duan, Yanping AU - Duan Y AD - Department of Sports and Health Sciences, Hong Kong Baptist University, Hong Kong Special Administrative Region of China. FAU - Peiris, D L I H K AU - Peiris DLIHK AD - Department of Sport Science and Physical Education, University of Kelaniya, Sri Lanka. FAU - Vandelanotte, Corneel AU - Vandelanotte C AD - Physical Activity Research Group, Central Queensland University, Australia. FAU - Liang, Wei AU - Liang W AD - School of Physical Education, Shenzhen University, China. LA - eng PT - Journal Article DEP - 20260713 PL - Singapore TA - J Exerc Sci Fit JT - Journal of exercise science and fitness JID - 101198241 PMC - PMC13400259 OTO - NOTNLM OT - Accelerometers OT - BCT OT - COM-B model OT - Pre-adolescents OT - Seated learning COIS- The authors declare that they have no competing interests. EDAT- 2026/07/26 06:42 MHDA- 2026/07/26 06:43 PMCR- 2026/07/13 CRDT- 2026/07/26 04:07 PHST- 2026/02/09 00:00 [received] PHST- 2026/06/21 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/26 06:43 [medline] PHST- 2026/07/26 06:42 [pubmed] PHST- 2026/07/26 04:07 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - S1728-869X(26)00059-6 [pii] AID - 200498 [pii] AID - 10.1016/j.jesf.2026.200498 [doi] PST - ppublish SO - J Exerc Sci Fit. 2026 Oct;24(4):200498. doi: 10.1016/j.jesf.2026.200498. Epub 2026 Jul 13. PMID- 42502158 OWN - NLM STAT- MEDLINE DCOM- 20260725 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 24 TI - Study protocol for Full Speed Ahead: an intervention for improved activities in daily life through Frame Running and Goal directed training. LID - 10.1186/s12887-026-07318-z [doi] LID - 684 AB - BACKGROUND: Early and intensive intervention is crucial for children with cerebral palsy (CP), particularly during the period when gross motor activities typically develop. Despite the prevalence of CP, robust evidence for effective early mobility interventions remains limited. Frame Running, which enables children with limited walking ability to engage in dynamic, high-intensity activities, has emerged as a promising approach, yet research on its effect in young children is currently lacking. The aim of this study is to implement and evaluate the effects of a mobility-focused training program combining Frame Running and goal-directed gross motor training, on mobility in every day life and cardiovascular health in children aged 2-5 years with CP. METHOD: The study uses a prospective repeated-measures intervention design with assessments conducted during baseline, intervention, and post-intervention follow-up phases. At least 18 children meeting the inclusion criteria (CP diagnosis, age 2-5 years, GMFCS II-IV) will participate. The design consists of three baseline measurements, a 12-week intervention phase and three post-intervention measurements, across approximately 5-6 months. The program combines home-based training and hospital-based group training, with parents as active trainers and therapists providing coaching. Frame Running and goal-directed training are tailored to individual goals, set collaboratively with families. Outcome measures include the Gross Motor Function Measure (GMFM-66), Functional Mobility Scale (FMS), Paediatric Evaluation of Disability Inventory Computerised Assessment Test (PEDI-CAT), time-based mobility tests: ultrasound assessment of muscle size and morphology, gait analysis, accelerometry (7-day activity monitoring), heart rate monitoring during training, and Goal Attainment Scaling (GAS). Feasibility and fidelity will be investigated by questionnaires. DISCUSSION: By evaluating the Full Speed Ahead program, this study aims to improve understanding of how an early intensive family-centered mobility intervention may influence developmental trajectories and health in children with CP. If effective, the findings will have significant implications for planning both short- and long-term treatment and services for young children with CP. The prospective repeated-measures intervention design allows for both group-level and individual-level analysis of changes over time, thereby strengthening the evidence base for early, intensive, family-centered mobility interventions. TRIAL REGISTRATION: ClinicalTrial.gov NCTO7374432, Registered November 18 2025. CI - (c) 2026. The Author(s). FAU - Eliasson, Ann-Christin AU - Eliasson AC AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. ann-christin.eliasson@ki.se. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. ann-christin.eliasson@ki.se. FAU - Lowing, Kristina AU - Lowing K AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Hjalmarsson, Emma AU - Hjalmarsson E AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Lidbeck, Cecilia AU - Lidbeck C AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. FAU - Adestedt, Agnes AU - Adestedt A AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Starck, Julia AU - Starck J AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. FAU - Aspdahl, Magnus AU - Aspdahl M AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Lowing, Josefin AU - Lowing J AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Frisk, Emelie AU - Frisk E AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Strand, Johanna AU - Strand J AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Ericson, Annika AU - Ericson A AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. FAU - Andersson, Kristina AU - Andersson K AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. FAU - Brostrom, Eva AU - Brostrom E AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. FAU - Kvist, Ola AU - Kvist O AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Department of Radiology, Columbia University, New York, USA. FAU - Norrbom, Jessica AU - Norrbom J AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. FAU - von Walden, Ferdinand AU - von Walden F AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. LA - eng SI - ClinicalTrials.gov/2024-05809-01, Registered November 18 2025 PT - Journal Article DEP - 20260724 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child, Preschool MH - *Cerebral Palsy/rehabilitation/physiopathology MH - Prospective Studies MH - *Running MH - *Activities of Daily Living MH - *Exercise Therapy/methods MH - Goals MH - Male MH - Female PMC - PMC13401323 OTO - NOTNLM OT - Cerebral palsy OT - Early intervention OT - Gait OT - Goal directed training and Frame running OT - Mobility OT - Muscle OT - Physical activity OT - Walking COIS- Declarations. Ethics approval and consent to participate: Full ethical approval for this study has been obtained from the Swedish Ethical Review Authority (Dnr 2024-05809-01). All parents will be given oral and written information about the study before being asked to sign an informed consent form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/26 00:42 MHDA- 2026/07/26 00:43 PMCR- 2026/07/24 CRDT- 2026/07/25 23:23 PHST- 2025/12/10 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/26 00:43 [medline] PHST- 2026/07/26 00:42 [pubmed] PHST- 2026/07/25 23:23 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.1186/s12887-026-07318-z [pii] AID - 7318 [pii] AID - 10.1186/s12887-026-07318-z [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 24;26(1):684. doi: 10.1186/s12887-026-07318-z. PMID- 42501948 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260916 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - The validity of measuring energy and nutrient intake with the Remote Food Photography Method (RFPM) in adolescents. PG - 101452 LID - S0002-9165(26)00261-3 [pii] LID - 10.1016/j.ajcnut.2026.101452 [doi] AB - BACKGROUND: The remote food photography method (RFPM) accurately estimates energy intake (EI) in adults, but its validity in adolescents has yet to be tested. Given the low accuracy of self-reported dietary intake in adolescents, evaluating the validity of the RFPM in both controlled and free-living settings is crucial. OBJECTIVES: To examine the validity of the RFPM in estimating adolescents' EI in controlled and free-living settings. METHODS: In Study 1, adolescents (n = 45) used the RFPM/SmartIntake application during 1) a laboratory test meal, 2) a cafeteria meal, and 3) 7 d of free-living intake, with EI estimations validated against weighed food intake, digital photography of foods method, and doubly labeled water, respectively. EI was measured under the same 3 settings with pen-and-paper food records. After refining the application and training, Study 2 (n = 22) repeated the protocol with a 3-d free-living period. For both studies, equivalence was evaluated using two one-sided t-tests (+/-10% bounds), and linear mixed models assessed RFPM error by participant characteristics. RESULTS: In Study 1, RFPM estimates of EI were equivalent to the criterion measure during cafeteria meals [mean standard deviation (SD) error: 4.1 (120.8) kcal; P = 0.005] but were not equivalent for the laboratory test meal [mean (SD) error: 61.1 (112.7) kcal; P = 0.675] and 7 d of free-living intake [mean (SD) error: -887.9 (554.8) kcal/d; P > 0.99]. In Study 2, RFPM EI estimates were equivalent to the criterion measure in the controlled setting [mean (SD) error: -2.2 (86.5) kcal; P = 0.007], but not in free-living settings [mean (SD) error: -782.8 (947.0) kcal/d; P = 0.99]. In both studies, a higher body mass index (in kg/m(2)) percentile was associated with greater underestimation of EI (both R(2) > 0.19 and P < 0.05). CONCLUSIONS: The RFPM can accurately estimate the meal-level EI of adolescents in controlled settings; however, significant underestimation occurred in free-living settings in both studies. Previous studies demonstrated the inability to accurately assess adolescents' free-living intake, and the current results extend these findings to the RFPM. This trial was registered at clinicaltrials.gov as Study 1: NCT01719445 (https://clinicaltrials.gov/study/NCT01719445) and Study 2: NCT04148560 (https://clinicaltrials.gov/study/NCT04148560). CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Hochsmann, Christoph AU - Hochsmann C AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States; Department of Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Diktas, Hanim E AU - Diktas HE AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Myers, Candice A AU - Myers CA AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Dorling, James L AU - Dorling JL AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States; Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. FAU - Rood, Jennifer C AU - Rood JC AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Greenway, Frank AU - Greenway F AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Champagne, Catherine M AU - Champagne CM AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Apolzan, John W AU - Apolzan JW AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Martin, Corby K AU - Martin CK AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. Electronic address: corby.martin@pbrc.edu. LA - eng SI - ClinicalTrials.gov/NCT04148560 SI - ClinicalTrials.gov/NCT01719445 GR - R01 DK089051/DK/NIDDK NIH HHS/United States GR - F32 HD116537/HD/NICHD NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - T32 DK064584/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States PT - Clinical Trial PT - Journal Article PT - Validation Study DEP - 20260725 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Diet Records MH - *Energy Intake MH - Nutrition Assessment MH - *Photography/methods MH - Reproducibility of Results PMC - PMC13573646 MID - NIHMS2206243 OTO - NOTNLM OT - RFPM OT - adolescents OT - dietary assessment OT - doubly labeled water OT - energy intake OT - remote food photography method COIS- Conflict of interest The intellectual property surrounding the remote food photography method and SmartIntake application is owned by Louisiana State University/Pennington Biomedical, and CKM is an inventor of the technology and is employed by Louisiana State University/Pennington Biomedical. All other authors report no conflicts of interest. EDAT- 2026/07/26 00:42 MHDA- 2026/09/01 23:34 PMCR- 2026/09/14 CRDT- 2026/07/25 19:13 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/26 00:42 [pubmed] PHST- 2026/07/25 19:13 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - S0002-9165(26)00261-3 [pii] AID - 10.1016/j.ajcnut.2026.101452 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101452. doi: 10.1016/j.ajcnut.2026.101452. Epub 2026 Jul 25. PMID- 42501820 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260923 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 75 DP - 2026 Oct TI - Genetically predicted breastfeeding propensity and brain microstructural morphology: Insights from genome-wide association study summary statistics and neurogenomics. PG - 103612 LID - S2405-4577(26)00709-6 [pii] LID - 10.1016/j.clnesp.2026.103612 [doi] AB - BACKGROUND: Breastfeeding provides nutrients and bioactive components relevant to infant development, but observational associations with brain outcomes may be influenced by socioeconomic, maternal, and family-level factors. Mendelian randomization (MR) offers a genetic framework for evaluating associations by using genetic variants as proxies for breastfeeding propensity; it does not directly measure the effect of actual breastfeeding behavior. OBJECTIVES: This study investigated associations between genetically predicted breastfeeding propensity and brain imaging-derived phenotypes (IDPs). METHODS: We performed a two-sample MR analysis using genome-wide association study (GWAS) summary statistics from 352,094 European participants. Genetically predicted breastfeeding propensity served as the exposure, and 393 brain IDPs from the UK Biobank served as outcomes. Double Machine Learning (DML), using random forest models and 5-fold cross-fitting, was applied as a complementary validation approach. Heterogeneity and pleiotropy analyses were conducted to assess the robustness of the instrumental-variable estimates. RESULTS: At the nominal significance level, positive MR estimates were observed between genetically predicted breastfeeding propensity and the left anterior thalamic radiation fractional anisotropy measure (IDP dMRI ProbtrackX FA atr l: Beta = 2.787, p = 0.045), the right lingual area (Beta = 2.032, p = 0.022), and the right superior temporal area (Beta = 1.719, p = 0.011). Inverse estimates were observed for measures including left mean cortical thickness (Beta = -2.266, p = 0.014). DML provided complementary evidence for associations involving the subcallosal gyrus and precentral thickness. Statistical power exceeded 80% for the primary outcomes; however, nominal findings that did not meet the Bonferroni threshold should be considered exploratory. CONCLUSIONS: This study provides genetic evidence of region-specific associations between genetically predicted breastfeeding propensity and brain structural phenotypes, including an association with higher fractional anisotropy in the left anterior thalamic radiation. Associations involving regions implicated in language, visual processing, and cortical maturation do not establish corresponding cognitive or functional effects. The findings are hypothesis-generating and require replication in independent and longitudinal datasets before direct behavioral or public health implications can be inferred. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Peng, Wan AU - Peng W AD - The Second Affiliated Hospital of Guangdong Medical University, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, China. FAU - Zheng, Lu AU - Zheng L AD - Department of Nursing and Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Huo, Fengjing AU - Huo F AD - The Second Affiliated Hospital of Guangdong Medical University, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, China. FAU - Gong, Huiting AU - Gong H AD - The Second Affiliated Hospital of Guangdong Medical University, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, China. FAU - Zhang, Ming AU - Zhang M AD - Department of Physical Medicine and Rehabilitation, Zibo Central Hospital, Zibo, China. Electronic address: signname@163.com. FAU - Zhu, Xiao AU - Zhu X AD - The Second Affiliated Hospital of Guangdong Medical University, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, China. Electronic address: xzhu@gdmu.edu.cn. LA - eng PT - Journal Article DEP - 20260725 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - *Genome-Wide Association Study MH - *Brain/diagnostic imaging/anatomy & histology MH - *Breast Feeding MH - Female MH - Mendelian Randomization Analysis MH - Phenotype MH - Magnetic Resonance Imaging MH - UK Biobank MH - Polymorphism, Single Nucleotide MH - Male MH - United Kingdom MH - Machine Learning OTO - NOTNLM OT - Brain imaging-derived phenotypes OT - Breastfeeding OT - Double machine learning OT - Mendelian randomization OT - Neurodevelopment COIS- Competing interests The authors declare that they have no competing interests. EDAT- 2026/07/26 00:42 MHDA- 2026/09/23 05:34 CRDT- 2026/07/25 19:12 PHST- 2026/05/07 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/18 00:00 [accepted] PHST- 2026/09/23 05:34 [medline] PHST- 2026/07/26 00:42 [pubmed] PHST- 2026/07/25 19:12 [entrez] AID - S2405-4577(26)00709-6 [pii] AID - 10.1016/j.clnesp.2026.103612 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Oct;75:103612. doi: 10.1016/j.clnesp.2026.103612. Epub 2026 Jul 25. PMID- 42500983 OWN - NLM STAT- Publisher LR - 20260725 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Jul 25 TI - Comparative assessment of preterm infant feeding strategies in government versus private neonatal intensive care units in Pakistan: A cross-sectional study. PG - 2601060261471951 LID - 10.1177/02601060261471951 [doi] AB - BackgroundEarly and adequate nutritional support in neonatal intensive care units (NICUs) is essential for reducing complications and mortality among preterm infants. Despite established guidelines, variations in feeding practices persist across healthcare settings.AimTo evaluate preterm feeding practices across NICUs in Pakistan and compare feeding strategies between government and private hospitals.MethodsA cross-sectional study was conducted to assess preterm feeding practices across Pakistani NICUs. Of the 100 NICUs approached, 48 (48%) participated in the study. Data was collected using a self-administered, validated questionnaire developed to evaluate hospital-based feeding practices, including feeding initiation protocols and adherence to clinical guidelines, fortification practices, barriers and challenges influencing feeding decisions, key determinants of feeding choices, growth monitoring protocols, and provision of lactation. The data were analyzed using chi-square, Fisher's exact test, and the Mann-Whitney U test, with significance at a 95% probability level.SummaryOne neonatologist from each NICU participated; most respondents had 1-5 years of experience (45.8%), and 60.4% were from private hospitals. Both settings showed comparable use of the mother's own milk. However, private hospitals had longer waiting times before initiating alternative feeding (median 1.00 vs. 0.00, p = 0.005) and lower immediate Kangaroo Mother Care initiation (48.3% vs. 84.2%, p = 0.039). Commercial fortifier use was higher in private hospitals (37.9% vs. 10.5%, p = 0.049), while medium-chain triglyceride oil was the most common fortifier overall. Private hospitals more frequently reported unavailability of expressed breast milk (55.2% vs. 26.3%, p = 0.049) and insufficient milk supply (89.6% vs. 47.4%, p = 0.001). Government hospitals more commonly identified untrained staff (52.6% vs. 17.2%, p = 0.01) and parental reluctance (57.9% vs. 27.6%, p = 0.036) as barriers. FAU - Latif, Samreen AU - Latif S AUID- ORCID: 0009-0005-8434-0372 AD - Department of Nutrition and Dietetics, University of Management and Technology, Lahore, Pakistan. RINGGOLD: 66915 FAU - Khalid, Nauman AU - Khalid N AUID- ORCID: 0000-0002-8045-199X AD - Department of Food Science and Technology, University of Management and Technology, Lahore, Pakistan. RINGGOLD: 66915 AD - College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates. LA - eng PT - Journal Article DEP - 20260725 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - NICU OT - Pakistan OT - Preterm infants OT - feeding practices OT - fortification EDAT- 2026/07/25 23:59 MHDA- 2026/07/25 23:59 CRDT- 2026/07/25 08:33 PHST- 2026/07/25 23:59 [medline] PHST- 2026/07/25 23:59 [pubmed] PHST- 2026/07/25 08:33 [entrez] AID - 10.1177/02601060261471951 [doi] PST - aheadofprint SO - Nutr Health. 2026 Jul 25:2601060261471951. doi: 10.1177/02601060261471951. PMID- 42500375 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260725 LR - 20260813 IS - 2231-0762 (Print) IS - 2250-1002 (Electronic) IS - 2231-0762 (Linking) VI - 16 IP - 3 DP - 2026 May-Jun TI - Association between Salivary Cortisol, Secretory IgA, and Inflammatory Cytokines with Early Childhood Caries: A Cross-sectional Analytical Study. PG - 279-284 LID - 10.4103/jispcd.jispcd_201_25 [doi] AB - OBJECTIVE: Early childhood caries (ECC) is a multifactorial disease driven by biological and psychosocial determinants. Identifying noninvasive biomarkers could improve risk stratification and personalized prevention. The aim of the study is to evaluate the association of salivary cortisol, total secretory immunoglobulin A (sIgA), and pro-inflammatory cytokines (interleukin-6 [IL-6], interleukin-1beta [IL-1beta], and tumor necrosis factor-alpha [TNF-alpha]) with ECC in preschool children.IL-1beta. MATHODS: This cross-sectional analytical study included 120 children aged 3-6 years (60 ECC; 60 caries-free). Unstimulated saliva was collected via passive drooling. Biomarkers were quantified using high-sensitivity enzyme-linked immunosorbent assay kits. Multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were performed, adjusting for age, sex, feeding practices, oral hygiene, and socioeconomic status (SES). RESULTS: Children with ECC exhibited significantly higher levels of salivary cortisol (8.92 + -2.11 vs. 5.21 + -1.98 ng/mL, P < 0.001), IL-6 (42.81 + -10.29 vs. 26.44+ -9.87 pg/mL, P < 0.001), and TNF-alpha (P = 0.002) compared to controls. Conversely, sIgA levels were significantly lower in the ECC group (11.34 + -4.12 vs.18.25 + -5.03 mg/dL, P < 0.001). ROC analysis identified cortisol (area under the curve [AUC] = 0.89) and sIgA (AUC = 0.86) as excellent diagnostic indicators. In the final multivariable model, cortisol (OR 3.94, 95% confidence interval [CI] 2.11-7.35) and sIgA (OR 0.44, 95% CI 0.28-0.70) remained independently associated with ECC after adjusting for SES and behavioral covariates. CONCLUSION: Salivary cortisol, sIgA, and inflammatory cytokines are significantly associated with ECC, reflecting complex interactions between stress physiology, mucosal immunity, and oral dysbiosis. While these biomarkers show promise as early-warning indicators, longitudinal data are required to establish their discriminatory utility for caries onset. CI - Copyright: (c) 2026 Journal of International Society of Preventive and Community Dentistry. FAU - Acharya, Sonu AU - Acharya S AD - Department of Pediatric and Preventive Dentistry, Institute of Dental Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India. FAU - Godhi, Brinda Suhas AU - Godhi BS AD - Department of Pediatric and Preventive Dentistry, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Nalawade, Triveni Mohan AU - Nalawade TM AD - Department of Paediatric Dentistry, Oman Dental College, Muscat, Oman. FAU - Mallikarjuna, Rachappa AU - Mallikarjuna R AD - Department of Paediatric Dentistry, Oman Dental College, Muscat, Oman. FAU - Shivagange, Vinay AU - Shivagange V AD - Department of Endodontolgy, Oman Dental College, Muscat, Oman. FAU - Alsenaidi, Amur AU - Alsenaidi A AD - Head of Clinical Affairs, Oman Dental College, Muscat, Oman. LA - eng PT - Journal Article DEP - 20260516 PL - India TA - J Int Soc Prev Community Dent JT - Journal of International Society of Preventive & Community Dentistry JID - 101618802 PMC - PMC13397212 OTO - NOTNLM OT - Cortisol OT - cytokines OT - early childhood caries OT - risk assessment OT - salivary biomarkers OT - secretory IgA COIS- There are no conflicts of interest. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:37 PMCR- 2026/05/16 CRDT- 2026/07/25 05:03 PHST- 2025/11/18 00:00 [received] PHST- 2026/02/10 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/07/25 06:37 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 05:03 [entrez] PHST- 2026/05/16 00:00 [pmc-release] AID - JISPCD-16-279 [pii] AID - 10.4103/jispcd.jispcd_201_25 [doi] PST - epublish SO - J Int Soc Prev Community Dent. 2026 May 16;16(3):279-284. doi: 10.4103/jispcd.jispcd_201_25. eCollection 2026 May-Jun. PMID- 42500238 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260725 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Psychological barriers in future food gatekeepers: How germ aversion and perceived infectability mediate nutrition-related food neophobia among pre-service preschool teachers. PG - 1863520 LID - 10.3389/fnut.2026.1863520 [doi] LID - 1863520 AB - BACKGROUND: The development of nutritional health literacy in early childhood is structurally influenced by adult food gatekeepers. Approached as a sociological study of food, this research investigates the relationship between Nutrition-Related Food Neophobia (NRFN) and Food Disgust (FD) among pre-service preschool teachers, examining the mediating roles of the Behavioral Immune System-specifically Perceived Infectability (PI) and Germ Aversion (GA)-as underlying behavioral determinants. METHODS: A cross-sectional survey was conducted among 548 pre-service preschool teachers (males 43.2%, females 56.8%) in Changsha, China. Participants completed validated scales including the Perceived Vulnerability to Disease Questionnaire, the Nutrition-Related Food Neophobia Scale, and the Food Disgust Scale, evaluating biofortified rice as a nutritional stimulus. Data were analyzed using a two-step Structural Equation Modeling (SEM) approach. RESULTS: SEM analysis revealed that NRFN was significantly and positively associated with FD. PI and GA collectively mediated this relationship, explaining 54.69% of the total effect. The mediating influence of GA (30.98%) was numerically larger than that of PI (23.71%), indicating that the hygiene training of future educators may inadvertently contribute to their affective, evolutionary resistance to novel nutritional foods over their cognitive immune assessments. CONCLUSION: Despite the formal health and nutritional training anticipated in pre-service educators, our findings suggest that evolutionary pathogen-avoidance mechanisms continue to be strongly associated with their food aversion. These psychological barriers can potentially limit the implementation fidelity of nutritional educational tools within the kindergarten's social space of food. Enhancing children's dietary diversity and health literacy could benefit from shifting preventive strategies upstream, integrating food sociology and evolutionary psychology into teacher-training programs to dismantle germ aversion and build psychological resilience. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article DEP - 20260710 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13397584 OTO - NOTNLM OT - food disgust OT - germ aversion OT - nutrition-related food Neophobia OT - perceived infectability OT - pre-service teachers COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:37 PMCR- 2026/07/10 CRDT- 2026/07/25 05:01 PHST- 2026/04/23 00:00 [received] PHST- 2026/06/19 00:00 [revised] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/07/25 06:37 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 05:01 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.3389/fnut.2026.1863520 [doi] PST - epublish SO - Front Nutr. 2026 Jul 10;13:1863520. doi: 10.3389/fnut.2026.1863520. eCollection 2026. PMID- 42500102 OWN - NLM STAT- Publisher LR - 20260813 IS - 2589-1081 (Electronic) IS - 2095-8811 (Print) IS - 2095-8811 (Linking) DP - 2026 May 12 TI - Drug-Induced Sleep Endoscopy in Children Predicts OSA Severity. LID - 10.1002/wjo2.70098 [doi] AB - BACKGROUND: While adenotonsillectomy (AT) is first line for pediatric obstructive sleep apnea (OSA), treatment failure is common. Drug-induced sleep endoscopy (DISE) provides dynamic airway assessment, but its role in predicting OSA severity requires clarification. This study correlates DISE findings with polysomnographic severity. OBJECTIVE: To determine the association between DISE-based obstruction patterns and OSA severity in children. METHODS: This prospective study included 95 children with adenotonsillar hypertrophy. All underwent preoperative Level III polysomnography followed by DISE before AT. Two blinded otolaryngologists independently reviewed DISE recordings, classifying obstruction via the VOTE system (degree 0-2; pattern: concentric, lateral, or anteroposterior). Statistical analysis employed non-parametric tests, relative risk calculation, and ROC curves. RESULTS: Severe OSA (AHI > 10) was significantly associated with Brodsky grade IV tonsils (40.7% vs. 16.7%) and severe adenoid hypertrophy (44.1% vs. 16.7%). DISE identified severe obstruction at the velopharynx (p = 0.003) and tongue base (p = 0.036) as specific predictors of severe OSA, with high specificities (91% and 97.1%) and positive predictive values (87.7% and 90.9%). Concentric collapse was the most frequent velopharyngeal pattern (54.2%). Obesity was significantly linked to severe tongue base obstruction (38.9% vs. 5.4%, p = 0.001) and higher AHI. ROC analysis for tongue base obstruction combined with the Obstructive Apnea Index (OAI) showed high diagnostic accuracy (AUC = 0.811). DISCUSSION AND CONCLUSION: DISE is a valuable tool for predicting pediatric OSA severity. Obstruction at the velopharynx and tongue base, particularly concentric collapse and in the context of obesity, are key risk factors. Integrating DISE findings with PSG enhances preoperative risk stratification, aiding in the selection of candidates who may benefit from personalized, multilevel surgical interventions. CI - (c) 2026 The Author(s). World Journal of Otorhinolaryngology - Head and Neck Surgery published by John Wiley & Sons Ltd on behalf of Chinese Medical Association. FAU - Carneiro, Neemias Santos AU - Carneiro NS AUID- ORCID: 0000-0002-7917-4374 AD - Sao Paulo State University, Botucatu Medical School (FMB-UNESP) Botucatu Sao Paulo Brazil. FAU - Marao, Antonio Carlos AU - Marao AC AUID- ORCID: 0000-0002-7948-329X AD - Clinical Hospital of the Faculty of Medicine of Botucatu (HCFMB) - UNESP Botucatu Sao Paulo Brazil. FAU - Santana, Renato Battistel AU - Santana RB AUID- ORCID: 0000-0002-3888-541X AD - Sao Paulo State University, Botucatu Medical School (FMB-UNESP) Botucatu Sao Paulo Brazil. FAU - Correa, Camila de Castro AU - Correa CC AUID- ORCID: 0000-0001-5460-3120 AD - University Vale do Rio Doce, UNIVALE, Governador Valadares Governador Valadares MG Brazil. FAU - Weber, Silke Anna Theresa AU - Weber SAT AUID- ORCID: 0000-0003-3194-3039 AD - Sao Paulo State University, Botucatu Medical School (FMB-UNESP) Botucatu Sao Paulo Brazil. LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - World J Otorhinolaryngol Head Neck Surg JT - World journal of otorhinolaryngology - head and neck surgery JID - 101690857 PMC - PMC13399433 OTO - NOTNLM OT - OSA OT - Z-score OT - adenoidectomy OT - sonoendoscopy OT - tonsillectomy COIS- The authors declare that there are no conflicts of interest related to this study. They have no financial, institutional, or personal relationships that could have influenced the work reported in this manuscript. No affiliations with any organization or publisher have biased the research. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:36 PMCR- 2026/05/12 CRDT- 2026/07/25 05:00 PHST- 2025/07/06 00:00 [received] PHST- 2025/12/01 00:00 [revised] PHST- 2026/02/01 00:00 [accepted] PHST- 2026/07/25 06:36 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 05:00 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - WJO270098 [pii] AID - 10.1002/wjo2.70098 [doi] PST - aheadofprint SO - World J Otorhinolaryngol Head Neck Surg. 2026 May 12:10.1002/wjo2.70098. doi: 10.1002/wjo2.70098. PMID- 42499772 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260829 LR - 20260829 IS - 2574-2272 (Electronic) IS - 2096-3726 (Print) IS - 2574-2272 (Linking) VI - 10 IP - 4 DP - 2026 Aug TI - Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone. PG - 359-373 LID - 10.1002/ped4.70050 [doi] AB - IMPORTANCE: Recombinant human growth hormone (rhGH) improves height in children with growth hormone deficiency (GHD). However, its metabolic effects remain unclear. OBJECTIVE: To synthesize evidence regarding the metabolic effects of rhGH or growth hormone (GH) derivatives in GHD, identify knowledge gaps, and highlight future research priorities. METHODS: PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine disc, and Wanfang databases were searched in July 2023 to identify studies on metabolic effects of GH treatment. Bubble plots were used to visualize GH treatment effects on metabolic parameters according to treatment duration by comparison with baselines, nonpharmacological interventions, and healthy controls. Random-effects meta-analyses were conducted for outcomes with inconsistent findings across original studies when randomized controlled trial data were sufficient. The study was registered with INPLASY (INPLASY202450064). RESULTS: Sixty-three studies (6158 participants) analyzed the effects of GH treatment on metabolic outcomes in children with GHD. Overall, GH treatment slightly affected glucose levels; lipid effects were inconsistent. GH treatment did not influence bone mineral density, bone mineral content, or parathyroid hormone levels. Most studies showed no significant effects on thyroid hormone levels, body composition, or body mass index (BMI). GH treatment may increase serum asymmetric dimethylarginine and gastrin levels while reducing tumor necrosis factor and serum urea levels. INTERPRETATION: Glucose and thyroid outcomes are consistent with clinical observations; effects on lipids, calcium, phosphorus, body composition, BMI, and waist-to-hip ratio require further validation owing to data inconsistency. New biomarkers are warranted. Further clinical studies are needed in children across age groups, GHD severities, and nutritional statuses. CI - (c) 2026 The Author(s). Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development. FAU - Wu, Wei AU - Wu W AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Song, Ningyi AU - Song N AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Zhao, Yue AU - Zhao Y AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Du, Caiqi AU - Du C AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Zhao, Yuning AU - Zhao Y AUID- ORCID: 0009-0007-2154-9624 AD - Medical Affairs Novo Nordisk (Shanghai) Pharma Trading Co., Ltd. No.8, Guangshunnan Beijing 100102 China. FAU - Wu, You AU - Wu Y AD - Medical Affairs Novo Nordisk (Shanghai) Pharma Trading Co., Ltd. No.8, Guangshunnan Beijing 100102 China. FAU - Luo, Xiaoping AU - Luo X AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. LA - eng PT - Journal Article PT - Review DEP - 20260311 PL - United States TA - Pediatr Investig JT - Pediatric investigation JID - 101731527 PMC - PMC13398671 OTO - NOTNLM OT - Evidence map OT - Growth hormone deficiency OT - Metabolism OT - Systematic review COIS- Wei Wu, Ningyi Song, Yue Zhao, and Caiqi Du declare no conflict of interest. Yuning Zhao and You Wu are employees and stockholders of Novo Nordisk, but are not involved in data processing. Xiaoping Luo serves as an advisor to GenSci, Amoytop, Novo Nordisk, Takeda, Lumos, Sanofi, Medtronic, Ipsen, Visen, and Kyowa Kirin, providing research support for GenSci, Amoytop, Novo Nordisk, Takeda, Lumos, Sanofi, Medtronic, Ipsen, Visen, and Kyowa Kirin, and is a speaker for GenSci, Novo Nordisk, and Visen. Xiaoping Luo is a member of the Pediatric Investigation Editorial Board. The study design, analytical plan, and interpretation remained under the full control of the academic authors, and the outcome selection was driven by clinical relevance and protocol pre-specification. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:37 PMCR- 2026/03/11 CRDT- 2026/07/25 04:58 PHST- 2025/07/08 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/07/25 06:37 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 04:58 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - PED470050 [pii] AID - 10.1002/ped4.70050 [doi] PST - epublish SO - Pediatr Investig. 2026 Mar 11;10(4):359-373. doi: 10.1002/ped4.70050. eCollection 2026 Aug. PMID- 42499750 OWN - NLM STAT- Publisher LR - 20260813 IS - 2691-171X (Electronic) IS - 2691-171X (Linking) DP - 2026 Jul 2 TI - A joint transdisciplinary approach for paediatric inflammatory bowel disease: Integrating nursing, dietetic and psychological support. LID - 10.1002/jpr3.70216 [doi] AB - Paediatric inflammatory bowel disease (pIBD) is a long-term, immune-mediated condition characterised by fluctuating gastrointestinal symptoms, nutritional risk and psychosocial difficulties. Although multidisciplinary team (MDT) support is considered the gold standard, there is considerable variation in how it is delivered, and it remains common for healthcare services to rely on separate discipline-specific appointments within the MDT. Here, we describe a transdisciplinary model for pIBD that integrates nursing, dietetic and psychological expertise within a joint appointment. Through the methodology of reflective practice, we identify several potential benefits, including more holistic symptom management, enhanced access to specialist input, reduced stigma around psychological support and improved cross-disciplinary learning. Potential implementation challenges include implementation feasibility, role ambiguity and demands on some service users. To the best of our knowledge, this paper represents an innovative model of care for pIBD. CI - (c) 2026 The Author(s). JPGN Reports published by Wiley Periodicals LLC on behalf of The European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Yau, King-Chi AU - Yau KC AUID- ORCID: 0000-0003-1778-9688 AD - Research Department of Clinical, Educational and Health Psychology University College London London UK. AD - Paediatric Gastroenterology, St Mark's Hospital London North West University Healthcare NHS Trust London UK. FAU - Tesser, Laura AU - Tesser L AD - Paediatric Gastroenterology, St Mark's Hospital London North West University Healthcare NHS Trust London UK. FAU - Crook, Kay AU - Crook K AD - Paediatric Gastroenterology, St Mark's Hospital London North West University Healthcare NHS Trust London UK. LA - eng PT - Journal Article DEP - 20260702 PL - United States TA - JPGN Rep JT - JPGN reports JID - 101773885 PMC - PMC13399047 OTO - NOTNLM OT - child OT - gastroenterology OT - multidisciplinary COIS- The authors declare no conflicts of interest. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:36 PMCR- 2026/07/02 CRDT- 2026/07/25 04:58 PHST- 2025/12/24 00:00 [received] PHST- 2026/03/04 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/07/25 06:36 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 04:58 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - JPR370216 [pii] AID - 10.1002/jpr3.70216 [doi] PST - aheadofprint SO - JPGN Rep. 2026 Jul 2:10.1002/jpr3.70216. doi: 10.1002/jpr3.70216. PMID- 42499215 OWN - NLM STAT- Publisher LR - 20260725 IS - 1544-0591 (Electronic) IS - 0022-0345 (Linking) DP - 2026 Jul 24 TI - Salivary Dipeptides and Microbiota Multiomics Biomarkers of Caries. PG - 220345261466143 LID - 10.1177/00220345261466143 [doi] AB - Dental caries is a prevalent disease shaped by dietary and metabolic interactions between the host and oral microbiota. While separate microbiome and metabolome profiling have improved the understanding of caries etiology, integrated multiomics approaches remain underutilized. We aimed to identify salivary biomarkers of caries experience in a cross-sectional study combining microbiome, metabolome, sugarome, and diet, oral, and demographic information in 217 healthy Swedish adolescents and young adults. Participants underwent clinical examination, dietary assessment, and saliva analysis using full-length 16S rRNA gene sequencing, untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics, and 2-dimensional gas chromatography-MS (GCxGC-MS)-based sugar profiling. Caries signs and restorations were summarized as decayed and filled surfaces including enamel caries. Associations between caries experience, demographics, and omics measures were evaluated using a nested cross-validated linear-regression framework with inner-loop feature selection and outer-loop performance assessment, emphasizing effect-direction stability and reproducibility across cross-validation models. Selected OMICs features were then integrated using orthogonal partial least-squares (OPLS) modeling. Three salivary dipeptides (Ser-Pro, Phe-His, and Thr-Gly) showed robust inverse associations with caries experience. Several cariogenic taxa, including Streptococcus mutans, Streptococcus sobrinus, Lactobacillus gasseri, and selected Actinomyces and Prevotella species, were positively associated with caries experience, whereas Veillonella rogosae, Stomatobaculum sp. HMT-097, and other taxa as well as 5 bacteria-predicted enzymes were associated with lower caries experience. Dietary variables and salivary sugars showed no consistent associations with caries experience. An integrated OPLS model incorporating demographics, microbiota composition, microbial-predicted enzymes, and metabolomics explained 41% of the variation in caries (R(2) = 0.41) with a cross-validated predictive ability of 30% (Q(2) = 0.30). This saliva-based multiomics framework revealed coherent microbial and metabolic signatures of caries experience. The Ser-Pro dipeptide showed the strongest inverse association and warrants validation in longitudinal cohorts to establish temporal precedence and clinical utility as a novel caries biomarker. FAU - Haworth, S AU - Haworth S AUID- ORCID: 0000-0001-7793-7326 AD - Department of Odontology, University of Umea, Umea, Sweden. AD - Bristol Dental School, University of Bristol, Bristol, UK. FAU - Esberg, A AU - Esberg A AUID- ORCID: 0000-0002-4430-8125 AD - Department of Odontology, University of Umea, Umea, Sweden. FAU - Eriksson, L AU - Eriksson L AD - Department of Odontology, University of Umea, Umea, Sweden. FAU - Ahmed, H AU - Ahmed H AD - Department of Life Technologies, Food Sciences Unit, University of Turku, Turku, Finland. FAU - Mack, C I AU - Mack CI AD - Max Rubner-Institute, Department of Safety and Quality of Fruit and Vegetables, Karlsruhe, Germany. FAU - Noerman, S AU - Noerman S AD - Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore. AD - Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden. FAU - Nordin, E AU - Nordin E AD - Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden. FAU - Egert, B AU - Egert B AD - Max Rubner-Institute, Department of Safety and Quality of Fruit and Vegetables, Karlsruhe, Germany. FAU - Hanhineva, K AU - Hanhineva K AD - Department of Life Technologies, Food Sciences Unit, University of Turku, Turku, Finland. FAU - Landberg, R AU - Landberg R AD - Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden. FAU - Brunius, C AU - Brunius C AD - Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore. FAU - Johansson, I AU - Johansson I AD - Department of Odontology, University of Umea, Umea, Sweden. LA - eng PT - Journal Article DEP - 20260724 PL - United States TA - J Dent Res JT - Journal of dental research JID - 0354343 SB - IM OTO - NOTNLM OT - dental caries OT - metabolomics OT - microbiome OT - omics OT - saliva OT - sugars EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:36 CRDT- 2026/07/25 01:53 PHST- 2026/07/25 06:36 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 01:53 [entrez] AID - 10.1177/00220345261466143 [doi] PST - aheadofprint SO - J Dent Res. 2026 Jul 24:220345261466143. doi: 10.1177/00220345261466143. PMID- 42499051 OWN - NLM STAT- MEDLINE DCOM- 20260725 LR - 20260821 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 30 DP - 2026 Jul 24 TI - Research status, hotspots, and frontiers in functional abdominal pain syndrome: A bibliometric and visual analysis. PG - e49899 LID - 10.1097/MD.0000000000049899 [doi] LID - e49899 AB - BACKGROUND: Functional abdominal pain syndrome (FAPS) is a relatively uncommon functional gastrointestinal disorder. Recent years have witnessed substantial advancements in the study of FAPS; however, no bibliometric analyses have been conducted to date. OBJECTIVE: This study systematically reviews current research and emerging issues in the field of FAPS using bibliometric methods to understand research trends and future development prospects. METHODS: The foundational literature in the field of FAPS was sourced from the Web of Science database. Visual analysis was performed using CiteSpace and VOSviewer software, focusing on factors such as the number of published papers, countries (regions), research institutions, journals, authors, highly cited papers, and keywords. RESULTS: From 1996 to 2025, 996 publications were analyzed, showing a phased growth in annual publication volume peaking in 2021. The United States led in publications and centrality. The "Journal of Pediatric Gastroenterology and Nutrition" had the highest publication count. Marc A. Benninga authored the most articles, notably "Functional Disorders: Children and Adolescents." The prevalent keyword was "children." Research on FAPS focuses on evolving disease definitions, the "brain-gut interaction disorder" paradigm, the microbiota-gut-brain axis, children with irritable bowel syndrome, functional abdominal pain, and nonpharmaceutical therapies like probiotics, dietary interventions, and cognitive behavioral therapy. Pediatric populations and non-pharmacological interventions were the most prominent themes, whereas adult-specific research and biomarker-related studies appeared less frequently. CONCLUSION: This bibliometric study identified key research areas including the microbiota-gut-brain axis, pediatric populations, and non-pharmacological interventions, alongside emerging topics such as gut-brain interaction disorders. These findings suggest that future research should prioritize large-scale trials validating non-pharmacological therapies and biomarkers for central sensitization. Clinically, the development of age-specific diagnostic protocols and interdisciplinary management teams integrating gastroenterology, neurology, and psychology is warranted to improve patient outcomes. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Zhou, Ziqin AU - Zhou Z AUID- ORCID: 0009-0009-0176-9771 AD - Department of Acupuncture and Moxibustion, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. FAU - Liu, Liu AU - Liu L AUID- ORCID: 0009-0001-2866-3303 AD - Department of Acupuncture and Moxibustion, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. FAU - Fu, Jia AU - Fu J AD - The Fourth School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Yan, Huixin AU - Yan H AD - Affiliated Hospital of Nanjing University with Chinese Medicine, Nanjing, China. FAU - Sheng, Yan AU - Sheng Y AD - Affiliated Hospital of Nanjing University with Chinese Medicine, Nanjing, China. FAU - Zhang, Zhaohui AU - Zhang Z AUID- ORCID: 0000-0002-6154-3901 AD - Department of Acupuncture and Moxibustion, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article PT - Review PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Bibliometrics MH - *Abdominal Pain/therapy MH - *Gastrointestinal Diseases PMC - PMC13406295 OTO - NOTNLM OT - Functional abdominal pain syndrome OT - Web of Science OT - bibliometric analysis OT - gut-brain axis OT - research trends COIS- The authors have no conflicts of interest to declare. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:37 PMCR- 2026/07/24 CRDT- 2026/07/25 01:03 PHST- 2026/03/12 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/25 06:37 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 01:03 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 00005792-202607240-00030 [pii] AID - MD-D-26-03905 [pii] AID - 10.1097/MD.0000000000049899 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jul 24;105(30):e49899. doi: 10.1097/MD.0000000000049899. PMID- 42498542 OWN - NLM STAT- Publisher LR - 20260724 IS - 1873-4588 (Electronic) IS - 0892-1997 (Linking) DP - 2026 Jul 24 TI - Evidence for Standalone Voice Therapy in the Management of Spasmodic Dysphonia: A Systematic Review and Identification of Research Gaps. LID - S0892-1997(26)00348-6 [pii] LID - 10.1016/j.jvoice.2026.06.054 [doi] AB - BACKGROUND: Spasmodic dysphonia is characterized by involuntary spasms of the laryngeal muscles occurring during vocal fold adduction or abduction; the underlying cause remains unknown. Management of spasmodic dysphonia ranges from surgical interventions and voice therapy to pharmacological injections into the laryngeal musculature; however, no currently available treatment provides a permanent cure. In routine practice, these patients often initially consult a voice or speech-language pathologist. Voice pathologists therefore require evidence-based research findings regarding the potential utility of initiating therapy alone versus early referral to a laryngologist, as well as identifying which types and severities of spasmodic dysphonia may benefit from standalone voice therapy. OBJECTIVE: To systematically evaluate the available evidence regarding standalone voice therapy as a treatment approach for individuals with spasmodic dysphonia and identify existing evidence gaps. STUDY DESIGN: Systematic review. METHODS ELIGIBILITY CRITERIA POPULATION: Studies involving children or adults diagnosed with all subtypes of spasmodic dysphonia (adductor, abductor, and mixed forms) through clinical and/or instrumental assessment were considered eligible for the study. Studies involving participants with an unconfirmed SD diagnosis, muscle tension dysphonia without SD, or structural/organic voice disorders unrelated to SD were excluded. Eligible study designs included randomized controlled trials, nonrandomized studies, cohort studies, before-and-after studies, and case series involving at least three participants. INTERVENTION: Studies involving patients undergoing standalone voice therapy, including behavioral voice therapy, resonant voice therapy, vocal function exercises, respiratory-phonatory coordination training, relaxation-based approaches, and compensatory voice strategies of any duration or frequency, were considered eligible. RISK OF BIAS: Risk of bias was planned using RoB 2 (randomized studies) and ROBINS-I (nonrandomized studies). This assessment was not performed due to the absence of included studies. SYNTHESIS OF RESULTS: A narrative synthesis was planned. Meta-analysis was not feasible due to the absence of eligible studies. RESULTS: A total of 29 records were identified through database searching and supplementary sources. All records were imported into Rayyan for screening. No duplicate records were removed. During title and abstract screening, 22 records were excluded as they did not meet the eligibility criteria. Seven articles were retrieved for full-text assessment. Following full-text review, all seven articles were excluded due to the inclusion of botulinum toxin as part of the intervention, absence of standalone voice therapy outcomes, or non-interventional study designs. Therefore, no studies met the inclusion criteria for qualitative or quantitative synthesis INTERPRETATION: This systematic review identified a critical evidence gap regarding standalone voice therapy for spasmodic dysphonia. The absence of eligible studies prevents conclusions regarding effectiveness, but highlights the need for rigorous prospective studies evaluating patient selection, intervention protocols, and clinically meaningful outcomes. CI - Copyright (c) 2026 The Voice Foundation. Published by Elsevier Inc. All rights reserved. FAU - Sebastian, Swapna AU - Sebastian S AD - Christian Medical College Vellore, Vellore, Tamil Nadu, India. Electronic address: swapnasanthoshchris@gmail.com. FAU - Roshini, V S AU - Roshini VS AD - Christian Medical College Vellore, Vellore, Tamil Nadu, India. FAU - Thanooja, C V AU - Thanooja CV AD - Christian Fellowship Hospital, Dindigul - Palani Main Road, Oddanchatram, Dindigul District, Tamil Nadu, 624 619, India. LA - eng PT - Journal Article PT - Review DEP - 20260724 PL - United States TA - J Voice JT - Journal of voice : official journal of the Voice Foundation JID - 8712262 SB - IM OTO - NOTNLM OT - Behavioral therapy OT - Laryngeal dystonia OT - Spasmodic dysphonia OT - Systematic review OT - Voice therapy COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/25 00:35 MHDA- 2026/07/25 00:35 CRDT- 2026/07/24 21:51 PHST- 2026/05/27 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/25 00:35 [medline] PHST- 2026/07/25 00:35 [pubmed] PHST- 2026/07/24 21:51 [entrez] AID - S0892-1997(26)00348-6 [pii] AID - 10.1016/j.jvoice.2026.06.054 [doi] PST - aheadofprint SO - J Voice. 2026 Jul 24:S0892-1997(26)00348-6. doi: 10.1016/j.jvoice.2026.06.054. PMID- 42497592 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260831 IS - 1872-8464 (Electronic) IS - 0165-5876 (Linking) VI - 208 DP - 2026 Sep TI - Vestibular Infant Screening - Rehabilitation: A pilot study assessing preliminary effectiveness and feasibility of vestibular rehabilitation therapy in children with peripheral vestibular dysfunction. PG - 112957 LID - S0165-5876(26)00253-3 [pii] LID - 10.1016/j.ijporl.2026.112957 [doi] AB - OBJECTIVES: This pilot study aims to evaluate the preliminary effects and feasibility of the Vestibular Infant Screening - Rehabilitation (VIS-REHAB) protocol, a structured Vestibular Rehabilitation Therapy (VRT) program combining postural and gaze stability exercises, in children with peripheral vestibular dysfunction. METHODS: Four children (aged 4-14 years) with peripheral vestibular dysfunction were recruited from the Ghent University Hospital and enrolled in a two-parallel-group randomized controlled crossover trial comparing the VIS-REHAB protocol with a no-therapy control. The VIS-REHAB protocol consisted of structured exercises targeting postural (20 min) and gaze stability (10 min), delivered in 30-min sessions twice weekly over nine weeks. Primary and secondary outcome measures included postural stability, gaze stability, motor performance, and quality of life. Descriptive analyses were conducted for each participant. RESULTS: All participants demonstrated improvements in the postural (Bruininks-Oseretsky Test of Motor Proficiency (BOT-2) Balance Subtest) and gaze stability (Gaze Stabilization Test) during therapy, while changes during the no-therapy period were more variable and generally less pronounced. Among the secondary outcomes, improvements were observed in the Pediatric Modified Dynamic Gait Index, BOT-2 Bilateral Coordination Subtest, and Dynamic Visual Acuity Test. Children and caregivers reported better balance, a perceived reduction in falls, and increased participation in daily life. The protocol was feasible and well-tolerated, though some age-related limitations were noted. CONCLUSIONS: The protocol is feasible and may improve postural and gaze stability in children with peripheral vestibular dysfunction. A larger trial is planned to confirm these findings. This research presents an important first step towards developing evidence-based guidelines for pediatric VRT. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Fontaine, Marieke AU - Fontaine M AD - Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium; Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Marieke.Fontaine@UGent.be. FAU - De Leenheer, Els AU - De Leenheer E AD - Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Els.DeLeenheer@UGent.be. FAU - Van den Bossche, Lena AU - Van den Bossche L AD - Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Lena.VandenBossche@UGent.be. FAU - Van Hecke, Ruth AU - Van Hecke R AD - Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Ruth.VanHecke@UGent.be. FAU - Dhooge, Ingeborg AU - Dhooge I AD - Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Ingeborg.Dhooge@UGent.be. FAU - Braswell Christy, Jennifer AU - Braswell Christy J AD - School of Health Professions, Department of Physical Therapy, University of Alabama at Birmingham, 1716 9th Avenue South, Birmingham, AL, 35233, United States. Electronic address: jbraswel@uab.edu. FAU - Maes, Leen AU - Maes L AD - Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Leen.Maes@UGent.be. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260721 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 SB - IM MH - Humans MH - Pilot Projects MH - Child MH - Child, Preschool MH - Male MH - Female MH - *Vestibular Diseases/rehabilitation/diagnosis/physiopathology MH - Feasibility Studies MH - Postural Balance/physiology MH - Adolescent MH - Cross-Over Studies MH - Treatment Outcome MH - *Exercise Therapy/methods MH - Quality of Life MH - Vestibular Function Tests OTO - NOTNLM OT - Gaze stability OT - Pediatric vestibular rehabilitation OT - Pediatric vestibular rehabilitation therapy OT - Postural control OT - Vestibular dysfunction OT - Vestibular rehabilitation OT - Vestibular rehabilitation therapy COIS- Declaration of competing interest The authors declare that they have no known competing financial interest or personal relationship that could have appeared to influence the work reported in this paper. EDAT- 2026/07/25 00:35 MHDA- 2026/08/18 23:36 CRDT- 2026/07/24 18:07 PHST- 2025/12/09 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/19 00:00 [accepted] PHST- 2026/08/18 23:36 [medline] PHST- 2026/07/25 00:35 [pubmed] PHST- 2026/07/24 18:07 [entrez] AID - S0165-5876(26)00253-3 [pii] AID - 10.1016/j.ijporl.2026.112957 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2026 Sep;208:112957. doi: 10.1016/j.ijporl.2026.112957. Epub 2026 Jul 21. PMID- 42497365 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260724 LR - 20260813 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Jul 24 TI - AI and Chatbot-Supported Interventions for Physical Activity and Obesity-Related Lifestyle Behaviors: Scoping Review With Attention to Family Involvement. PG - e98889 LID - 10.2196/98889 [doi] LID - e98889 AB - BACKGROUND: AI-enabled chatbots and related conversational systems can facilitate human-computer interaction through natural language, personalization, and automated support. In pediatric health promotion, these tools have the potential to provide scalable and flexible approaches to support physical activity (PA) and related lifestyle behavior change within family contexts. However, evidence regarding AI and chatbot-supported interventions for PA and obesity-related lifestyle behaviors among children and adolescents remains limited, and the extent to which these interventions involve parents, caregivers, or families has not been clearly characterized. OBJECTIVE: This scoping review aimed to provide an up-to-date overview of how AI and chatbot-supported interventions are designed, delivered, and evaluated for PA and obesity-related lifestyle behaviors among children and adolescents, with attention to technology characteristics, family involvement, delivery platforms, outcomes, and research gaps. METHODS: In accordance with PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guideline, 7 databases (PubMed, Web of Science, APA PsycINFO, Academic Search Complete, CINAHL Ultimate, IEEE Xplore, and Scopus) were searched through February 2026. Two reviewers independently conducted title and abstract screening, followed by full-text screening in Rayyan (Qatar Computing Research Institute). Eligible studies involved children, adolescents, or families; evaluated an AI-enabled chatbot, conversational agent, or related digital system; and addressed PA, exercise, sedentary behavior, screen time, obesity, overweight, or weight management. Diet, sleep, and other lifestyle outcomes were extracted when reported within otherwise eligible studies. Data were extracted and synthesized narratively in accordance with research objectives. RESULTS: Of 2730 records identified, 14 studies met inclusion criteria. Most were published in 2023 or later (n=12, 85.7%) and spanned 10 countries. Mobile app delivery was most common (n=9, 64.3%). AI approaches included rule-based chatbots, hybrid personalization systems, generative AI, and single studies using recommender systems or computer vision. A total of 10 studies (71.4%) included a specific parent, caregiver, or family component. Common intervention features were personalized feedback (n=10, 71.4%), self-monitoring (n=9, 64.3%), and education (n=9, 64.3%). PA was the most common target behavior, often within broader obesity or healthy lifestyle interventions. Among 8 studies reporting direct PA or fitness outcomes, 4 showed significant improvement, 2 found no significant change, and 2 reported mixed or indirect findings. Feasibility, acceptability, usability, and engagement findings were generally favorable across studies, but cultural tailoring was reported in only one study. CONCLUSIONS: AI and chatbot-supported interventions for pediatric PA and obesity-related lifestyle behaviors represent a rapidly emerging but still early-stage field. Family involvement varies considerably across interventions and should be more clearly conceptualized and evaluated in future studies. CI - (c) Qianxia Jiang, Xiayu Summer Chen, Dev Patel, Keith Brazendale, Sualba Alejandro. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Jiang, Qianxia AU - Jiang Q AUID- ORCID: 0000-0003-2230-6097 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. FAU - Chen, Xiayu Summer AU - Chen XS AUID- ORCID: 0000-0003-3747-3947 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. AD - School of Social Work, University of Central Florida, Florida, United States. FAU - Patel, Dev AU - Patel D AUID- ORCID: 0009-0009-9264-0294 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. AD - College of Medicine, University of Central Florida, Florida, United States. FAU - Brazendale, Keith AU - Brazendale K AUID- ORCID: 0000-0001-9233-1621 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. FAU - Alejandro, Sualba AU - Alejandro S AUID- ORCID: 0009-0001-4004-1494 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. LA - eng PT - Journal Article PT - Review DEP - 20260724 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13399406 OTO - NOTNLM OT - artificial intelligence OT - chatbot OT - family-based intervention OT - lifestyle behaviors OT - pediatric obesity OT - physical activity COIS- Conflicts of Interest: None declared. EDAT- 2026/07/24 18:36 MHDA- 2026/07/24 18:37 PMCR- 2026/07/24 CRDT- 2026/07/24 15:52 PHST- 2026/04/20 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/24 18:37 [medline] PHST- 2026/07/24 18:36 [pubmed] PHST- 2026/07/24 15:52 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - v9i1e98889 [pii] AID - 98889 [pii] AID - 10.2196/98889 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Jul 24;9:e98889. doi: 10.2196/98889. PMID- 42496625 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261007 IS - 1878-2620 (Electronic) IS - 1499-4046 (Print) IS - 1499-4046 (Linking) VI - 58 IP - 10 DP - 2026 Oct TI - Hispanic Parent Preferences for Approaching the Weight of Their 8-12-Year-Old Child: A Qualitative Study. PG - 945-955 LID - S1499-4046(26)00150-8 [pii] LID - 10.1016/j.jneb.2026.05.017 [doi] AB - OBJECTIVE: Characterize parents' views and preferences for managing their child's weight. DESIGN: Semistructured interviews with Hispanic primary caregivers whose health care provider told them their 8-12-year-old child's weight was above the recommended weight for their age. SETTING: Virtual interviews. PARTICIPANTS: The community sample of participants (n = 16) were primarily mothers (81%), immigrants (94%), and aged 37 +/- 6 years. Participants were from Mexico (56%), Ecuador (19%), Colombia (13%), El Salvador (6%), and the US (6%). PHENOMENON OF INTEREST: Parent perceptions of and preferences for weight management and weight-inclusive paradigms. ANALYSIS: Inductive thematic analysis. RESULTS: We identified 3 themes. First, parents consider context to decide how to address their child's weight. Second, parents view weight management as a personal responsibility that is made challenging by environmental barriers. Third, parents follow guidance from sources they feel are reliable and relatable. CONCLUSIONS AND IMPLICATIONS: Parent perspectives aligned with aspects of both weight management and weight-inclusive paradigms. In practice, these themes indicate parents are likely to want clear, specific guidance on weight that is sensitive to personal factors (e.g., child developmental stage, culture), structural barriers (e.g., time, access, affordability), and that clarifies expectations about potential outcomes from pursuing either approach. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Goodman, Lenora P AU - Goodman LP AD - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. Electronic address: goodm315@umn.edu. FAU - Galvez, Gianfranco Morote AU - Galvez GM AD - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. FAU - Frias, Gabriela Michelle Romero AU - Frias GMR AD - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. FAU - Hendel, Katherine R AU - Hendel KR AD - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. LA - eng GR - T32 DK083250/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260724 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Child MH - Female MH - *Hispanic or Latino/statistics & numerical data/psychology MH - *Parents/psychology MH - Male MH - Adult MH - Qualitative Research MH - Body Weight MH - *Pediatric Obesity/prevention & control PMC - PMC13492097 MID - NIHMS2198910 OTO - NOTNLM OT - nutrition counseling OT - obesity OT - preadolescence OT - social determinants of health OT - weight management COIS- CONFLICT OF INTEREST DISCLOSURE The authors have not stated any conflicts of interest. EDAT- 2026/07/24 12:37 MHDA- 2026/10/05 23:29 PMCR- 2026/08/21 CRDT- 2026/07/24 10:28 PHST- 2025/04/02 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/10/05 23:29 [medline] PHST- 2026/07/24 12:37 [pubmed] PHST- 2026/07/24 10:28 [entrez] PHST- 2026/08/21 00:00 [pmc-release] AID - S1499-4046(26)00150-8 [pii] AID - 10.1016/j.jneb.2026.05.017 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Oct;58(10):945-955. doi: 10.1016/j.jneb.2026.05.017. Epub 2026 Jul 24. PMID- 42496475 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260724 LR - 20260826 IS - 2036-749X (Print) IS - 2036-7503 (Electronic) IS - 2036-749X (Linking) VI - 18 IP - 4 DP - 2026 Jul 13 TI - Multicomponent Nutritional Support for Children with Autism Spectrum Disorder: An Exploratory Pilot Study in Vietnam. LID - 10.3390/pediatric18040097 [doi] LID - 97 AB - BACKGROUND: Children with Autism Spectrum Disorder (ASD) frequently exhibit severe food selectivity and micronutrient deficiencies, impacting growth and nutritional status. Evidence on integrated nutritional interventions in resource-constrained settings remains limited. OBJECTIVE: To assess the feasibility and preliminary pre-post changes associated with a 12-week multicomponent nutritional intervention among Vietnamese children with ASD. METHODS: In this exploratory single-arm pilot study, 56 children with ASD (mean age 59.0 +/- 22.3 months; 80.4% male) were recruited from five community centers in Nghe An Province, Vietnam. The intervention comprised caregiver nutrition education, individualized dietary counseling, and daily multi-micronutrient supplementation. Anthropometric indicators, biochemical markers, feeding behaviors, and dietary intake were assessed at baseline and after 12 weeks. Pre-post changes were evaluated using paired statistical tests, and multivariable linear regression examined factors associated with growth response. RESULTS: The study achieved a 100% completion rate, with all 56 recruited participants finishing the 12-week intervention and all scheduled follow-up assessments. Among children < 60 months, mean Weight-for-Age Z-score (WAZ) increased from -0.66 to -0.28 and mean Height-for-Age Z-score (HAZ) from -1.18 to -0.97 (p < 0.001). For children older than 60 months, mean HAZ increased from -0.87 to -0.58 (p < 0.001) and Body Mass Index-for-Age Z-score (BAZ) from -0.20 to 0.06 (p = 0.006). Significant increases occurred in serum zinc (10.29 to 11.72 micromol/L; p = 0.001), ferritin (31.74 to 34.79 ng/mL; p = 0.001), and hemoglobin (122.73 to 124.77 g/L; p = 0.002), while albumin remained unchanged. Concurrent improvements were observed in feeding behaviors and nutrient-dense food intake. Regression analysis indicated that lower baseline anthropometric status was significantly associated with greater gains in WAZ and HAZ. CONCLUSIONS: This community-based multicomponent intervention was feasible and associated with short-term improvements in feeding behaviors, dietary intake, selected biomarkers, and growth measures in children with ASD, supporting further evaluation in randomized controlled trials. FAU - Phan, Ngoc Dieu Thi AU - Phan NDT AUID- ORCID: 0000-0001-7625-4523 AD - School of Preventive Medicine and Public Health, Hanoi Medical University, 1 Ton That Tung Street, Khuong Thuong Ward, Dong Da District, Hanoi 100000, Vietnam. AD - Faculty of Public Health, Vinh Medical University, 161 Nguyen Phong Sac Street, Hung Dung Ward, Vinh City 430000, Vietnam. FAU - Do, Toan Thi Thanh AU - Do TTT AUID- ORCID: 0000-0002-7049-7361 AD - School of Preventive Medicine and Public Health, Hanoi Medical University, 1 Ton That Tung Street, Khuong Thuong Ward, Dong Da District, Hanoi 100000, Vietnam. FAU - Nguyen, Tuan Van AU - Nguyen TV AD - Faculty of Medicine, Vinh Medical University, 161 Nguyen Phong Sac Street, Hung Dung Ward, Vinh City 430000, Vietnam. FAU - Trinh, Ngoc Bao AU - Trinh NB AD - Institute of Nutrition Research and Development, 48B Tang Bat Ho Street, Hai Ba Trung Ward, Hanoi 100000, Vietnam. FAU - Ngo, Huy Gia AU - Ngo HG AUID- ORCID: 0009-0006-5699-7390 AD - School of Preventive Medicine and Public Health, Hanoi Medical University, 1 Ton That Tung Street, Khuong Thuong Ward, Dong Da District, Hanoi 100000, Vietnam. FAU - Ho, Hoa Thi AU - Ho HT AUID- ORCID: 0009-0003-2934-2688 AD - Institute of Nutrition Research and Development, 48B Tang Bat Ho Street, Hai Ba Trung Ward, Hanoi 100000, Vietnam. FAU - Le, Tam Thi Thanh AU - Le TTT AD - Faculty of Medicine, Vinh Medical University, 161 Nguyen Phong Sac Street, Hung Dung Ward, Vinh City 430000, Vietnam. FAU - Ngo, Hiep Tri AU - Ngo HT AUID- ORCID: 0009-0003-9236-5735 AD - Faculty of Public Health, Vinh Medical University, 161 Nguyen Phong Sac Street, Hung Dung Ward, Vinh City 430000, Vietnam. LA - eng GR - Not applicable/Institute of Nutrition Research and Development/ PT - Journal Article DEP - 20260713 PL - Switzerland TA - Pediatr Rep JT - Pediatric reports JID - 101551542 PMC - PMC13398004 OTO - NOTNLM OT - Autism Spectrum Disorder OT - dietary intake OT - growth OT - micronutrients OT - nutrition counseling OT - nutritional intervention COIS- The authors declare no conflicts of interest. The sponsor (INRD) had no role in the design of the study, the collection, analysis, or interpretation of data, the writing of the manuscript, or the decision to publish the results. EDAT- 2026/07/24 12:37 MHDA- 2026/07/24 12:38 PMCR- 2026/07/13 CRDT- 2026/07/24 10:04 PHST- 2026/06/13 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/24 12:38 [medline] PHST- 2026/07/24 12:37 [pubmed] PHST- 2026/07/24 10:04 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - pediatric18040097 [pii] AID - pediatrrep-18-00097 [pii] AID - 10.3390/pediatric18040097 [doi] PST - epublish SO - Pediatr Rep. 2026 Jul 13;18(4):97. doi: 10.3390/pediatric18040097. PMID- 42495681 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260903 IS - 2475-0328 (Electronic) IS - 2475-0328 (Linking) VI - 10 IP - 5 DP - 2026 Sep TI - Lymphocyte-C-Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis. PG - 1586-1593 LID - 10.1002/ags3.70236 [doi] AB - BACKGROUND: Surgical site infection (SSI) is a major complication after ileal pouch-anal anastomosis (IPAA) in pediatric ulcerative colitis (UC), significantly impairing quality of life. The lymphocyte-to-C-reactive protein ratio (LCR), a composite marker of systemic inflammation and immune/nutritional status, has emerged as a potential predictor of postoperative outcomes. This study assessed the utility of preoperative LCR in predicting SSI in pediatric UC. METHODS: We retrospectively reviewed pediatric UC patients who underwent IPAA at Mie University Hospital between 2000 and 2024. Preoperative LCR values were analyzed, and the optimal cutoff for SSI prediction was determined using receiver operating characteristic (ROC) analysis. Multivariate logistic regression was performed to identify independent risk factors. SSI was defined according to CDC criteria within 30 days postoperatively. RESULTS: Among 57 patients, 11 (19.3%) developed SSI. The incidence was higher in three-stage procedures than in two-stage procedures (22.7% vs. 17.1%). In both groups, preoperative LCR was significantly lower in SSI-positive patients. ROC analysis demonstrated good discrimination (AUC: 0.80), with an optimal cutoff of LCR < 5000 (sensitivity: 90.9%, specificity: 71.7%). Multivariate analysis confirmed LCR < 5000 as an independent predictor of SSI (odds ratio [OR]: 6.34, 95% CI: 1.23-48.2, p = 0.027). CONCLUSION: Preoperative LCR is a simple, objective biomarker that reliably predicts SSI risk in pediatric UC patients undergoing IPAA. Incorporating LCR into preoperative risk stratification may enable personalized interventions, including nutritional optimization and tailored prophylaxis, to improve surgical outcomes. CI - (c) 2026 The Author(s). Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery. FAU - Koike, Yuhki AU - Koike Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Higashi, Koki AU - Higashi K AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Sato, Yuki AU - Sato Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Nagano, Yuka AU - Nagano Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Shimura, Tadanobu AU - Shimura T AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Kitajima, Takahito AU - Kitajima T AD - Department of Genomic Medicine Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Matsushita, Kohei AU - Matsushita K AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Okita, Yoshiki AU - Okita Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Okugawa, Yoshinaga AU - Okugawa Y AD - Department of Genomic Medicine Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Toiyama, Yuji AU - Toiyama Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. LA - eng PT - Journal Article DEP - 20260525 PL - Japan TA - Ann Gastroenterol Surg JT - Annals of gastroenterological surgery JID - 101718062 PMC - PMC13394443 OTO - NOTNLM OT - inflammatory bowel disease OT - lymphocyte C-reactive protein ratio OT - pediatric surgery OT - surgical site infection OT - ulcerative colitis COIS- The authors declare no conflicts of interest. EDAT- 2026/07/24 06:35 MHDA- 2026/07/24 06:36 PMCR- 2026/05/25 CRDT- 2026/07/24 05:07 PHST- 2026/01/07 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/24 06:36 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 05:07 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - AGS370236 [pii] AID - 10.1002/ags3.70236 [doi] PST - epublish SO - Ann Gastroenterol Surg. 2026 May 25;10(5):1586-1593. doi: 10.1002/ags3.70236. eCollection 2026 Sep. PMID- 42494750 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260724 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - The Effect of Screen Exposure and Early Language Stimulation on Language and Social Development of Children. PG - e113133 LID - 10.7759/cureus.113133 [doi] LID - e113133 AB - Introduction Excessive screen exposure during infancy and early childhood is linked to delayed language and social milestones. Prospective observational data regarding how natural, self-selected variations in screen reduction and caregiver-led language stimulation impact real-world milestones development remain limited. Aims and objectives The aim of this study is to prospectively evaluate the association between changes in screen exposure and caregiver language stimulation on language and social development in nine- to 18-month-old children who were initially exposed to excessive screen time. Methodology In this prospective cohort study, 72 children aged 9-18 months with a baseline screen exposure of more than two hours/day were followed up in a tertiary care hospital. During the six-month follow-up, we did not implement interventions or prescribe treatments but rather observed families and stratified them into two exposure cohorts based on validated monthly lifestyle diaries: Cohort A (spontaneous screen reduction to less than one hour/day plus natural early language stimulation by "serve-and-return" interactions, n=36): and Cohort B (spontaneous screen reduction only without structured language stimulation routines, n=36). Development was assessed using the Language Evaluation Scale Trivandrum (LEST) and Home Screen Questionnaire (HSQ) at baseline and at six months. We used multivariable linear regression to adjust for baseline confounders, including parental education and household socioeconomic status. Results At six-month follow-up, Cohort A infants had a significantly greater mean increase in overall LEST+HSQ scores than Cohort B (+16.3 vs. +7.4, p<0.001). After controlling for baseline demographics, Cohort A had significantly higher language scores in the independent domain (30.2+/-3.4 vs. 24.8+/-3.9, p<0.001) and social communication scores (28.2+/-3.1 vs. 24.4+/-3.5, p<0.001) than Cohort B. Conclusions Combining natural caregiver interaction with structured language stimulation and reduced screen time is much more associated with better language and social development outcomes than reducing screen time alone. Clinicians should emphasize the promotion of increased caregiver interaction during early childhood along with screen time restriction rather than screen restriction alone. CI - Copyright (c) 2026, Vijayakumar et al. FAU - Vijayakumar, Vimalraj AU - Vijayakumar V AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - T, Arunkumar AU - T A AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - R, Karthick Prasaad AU - R KP AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - Rangaraj, Suresh AU - Rangaraj S AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - K, Sridharini AU - K S AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - G, Hariharan AU - G H AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. LA - eng PT - Journal Article DEP - 20260721 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13394589 OTO - NOTNLM OT - early language stimulation OT - language development OT - pediatric screen time OT - screen exposure OT - social development COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee - SRM Medical College Hospital issued approval SRMIEC-ST1225-6001. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/24 06:35 MHDA- 2026/07/24 06:36 PMCR- 2026/07/21 CRDT- 2026/07/24 04:58 PHST- 2026/07/21 00:00 [accepted] PHST- 2026/07/24 06:36 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 04:58 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.7759/cureus.113133 [doi] PST - epublish SO - Cureus. 2026 Jul 21;18(7):e113133. doi: 10.7759/cureus.113133. eCollection 2026 Jul. PMID- 42494209 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1469-1833 (Electronic) IS - 1352-4658 (Linking) VI - 54 IP - 2 DP - 2026 Jun TI - Brief, early, and effective: evaluating CBT-T outcomes and change trajectories in a no-minimum threshold to access an eating disorder service. PG - 134-146 LID - 10.1017/S1352465826101350 [doi] AB - OBJECTIVE: Cognitive Behavioural Therapy-Ten (CBT-T) offers a briefer manualised approach to treatment of non-underweight eating disorders (EDs) compared with traditional therapy models, and has the potential to help services deliver timely access to care. This study evaluated CBT-T outcomes in a naturalistic setting, with a focus on session-by-session change patterns. METHOD: A total of 151 young adults received CBT-T in a no-threshold-to-access community ED service. Symptom trajectories were assessed using the ED-15 global scale and subscales (eating concern, weight/shape concern). Using intent-to-treat principle, linear mixed-effect models evaluated treatment effectiveness, and chi-squared and receiver operating characteristic (ROC) analyses explored associations between early symptom change and end-of-treatment remission. RESULTS: Treatment led to significant reductions in ED symptoms and psychosocial impairment, with large effect sizes. Reliable improvement in Weight/Shape Concern - but not Eating Concern - on ED-15 at session 4 significantly predicted ED symptom scores below the clinical cut-off at the last session. CONCLUSIONS: CBT-T is effective in reducing ED symptoms in young adults with non-underweight EDs. While engagement and progress prior to session 4 have been used to guide treatment planning, as stated in the treatment manual, only the change in weight/shape concern at session 4 appeared to be strongly predictive of outcome in this sample, whereas change in eating concern did not. Early changes in weight and shape concerns at initial sessions may be informative in predicting treatment outcome. The findings can support the future development of CBT-T and other brief ED interventions. FAU - Yim, See Heng AU - Yim SH AUID- ORCID: 0000-0002-2241-1017 AD - Department of Psychology, The University of Hong Kong, Hong Kong. ROR: https://ror.org/02zhqgq86 AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - Dore, Eve AU - Dore E AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - King, Emily AU - King E AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - Bloomfield, Ronelle AU - Bloomfield R AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - Malecka, Zuzanna AU - Malecka Z AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - Fialko, Laura AU - Fialko L AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 LA - eng PT - Journal Article DEP - 20260724 PL - United States TA - Behav Cogn Psychother JT - Behavioural and cognitive psychotherapy JID - 9418292 SB - IM MH - Humans MH - *Cognitive Behavioral Therapy/methods MH - *Feeding and Eating Disorders/therapy/psychology MH - Female MH - Young Adult MH - Male MH - Treatment Outcome MH - Adult MH - Adolescent OTO - NOTNLM OT - cognitive behavioural therapy OT - eating disorder OT - mechanisms of change OT - service delivery OT - young adults EDAT- 2026/07/24 06:35 MHDA- 2026/09/14 11:41 CRDT- 2026/07/24 03:03 PHST- 2026/09/14 11:41 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 03:03 [entrez] AID - S1352465826101350 [pii] AID - 10.1017/S1352465826101350 [doi] PST - ppublish SO - Behav Cogn Psychother. 2026 Jun;54(2):134-146. doi: 10.1017/S1352465826101350. Epub 2026 Jul 24. PMID- 42494086 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260813 IS - 1365-2834 (Electronic) IS - 0966-0429 (Print) IS - 0966-0429 (Linking) VI - 2026 IP - 1 DP - 2026 TI - An Equation to Estimate PICC Catheter Length in Very Low Birth Weight Infants. PG - e2067769 LID - 10.1155/jonm/2067769 [doi] LID - 2067769 AB - OBJECTIVE: Peripherally inserted central catheters (PICCs) are essential for very low birth weight infants (VLBWIs), but optimal insertion depth remains challenging. Existing estimation methods often yield suboptimal accuracy. This study aimed to develop and validate anthropometric parameter-based formulas to predict lower extremity PICC insertion depth using the first popliteal crease as an anatomical landmark in VLBWI, seeking to improve first-attempt success rates and procedural safety. METHODS: A prospective study was conducted in a tertiary NICU, enrolling 329 VLBWIs who underwent lower limb PICC insertion between May 2023 and May 2024. Data collected included sex, target vein for catheterization, body weight, length, head circumference at insertion, and vertical distance from the puncture site to the first popliteal crease. Pearson correlation and linear regression analyses were performed to examine associations between anthropometric parameters and optimal catheter length. Univariate prediction formulas (weight-based, length-based, and head circumference-based models) and multivariate regression models were established. Bland-Altman analysis was used to validate model agreement. RESULTS: Univariate regression analysis yielded the following: weight-based model: total insertion depth (cm) = [8.31 + (5 x body weight [kg])] +/- PS-PTC distance, where "+" applies when the puncture site is distal to the popliteal crease and "-" applies when proximal; 8.31 is the regression intercept and five is the regression slope coefficient. Length-based model: total insertion depth (cm) = [1.13 + (0.35 x body length [cm])] +/- PS-PTC distance; 1.13 is the intercept and 0.35 is the slope coefficient. Head circumference-based model: total insertion depth (cm) = [2.33 + (0.43 x head circumference [cm])] +/- PS-PTC distance; 2.33 is the intercept and 0.43 is the slope coefficient. Multivariate regression analysis established four combination models, with Model IV (weight + length + head circumference) showing optimal performance. CONCLUSION: Anthropometric parameter-based prediction formulas provide precise guidance for lower extremity PICC placement in VLBWI, enhancing placement success and safety. This approach supports individualized care and is especially valuable where ultrasound guidance is limited. CI - Copyright (c) 2026 Jiaxin Li et al. Journal of Nursing Management published by John Wiley & Sons Ltd. FAU - Li, Jiaxin AU - Li J AUID- ORCID: 0009-0004-5307-6807 AD - Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China. FAU - Dong, Yubing AU - Dong Y AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. FAU - Yu, Qingling AU - Yu Q AD - Guangzhou University of Chinese Medicine, Guangzhou, China, gzucm.edu.cn. FAU - Cao, Aifen AU - Cao A AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. FAU - Jiang, Shan AU - Jiang S AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. FAU - Huang, Yinsui AU - Huang Y AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. FAU - Xiong, Xiaoyun AU - Xiong X AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. LA - eng GR - SZGSP009/Guangdong Provincial High-level Clinical Key Specialty Project/ GR - JCYJ20250604191408012/Natural Science Foundation of Shenzhen Municipality/ GR - JCYJ20230807120213026/Shenzhen Science and Technology Innovation Program/ GR - JCYJ20240813115035045/Shenzhen Science and Technology Innovation Program/ GR - FYB2022004/Research Fund of Shenzhen Maternity & Child Healthcare Hospital/ GR - SZSM202211001/Shenzhen "Sanming" Project of Medicine/ GR - ZDSYS20230626091559006/Key Laboratory for Pregnancy Disorders and Maternal and Child Health of Shenzhen/ GR - 2025FYH21/National Health Commission of the People's Republic of China/ PT - Journal Article PL - England TA - J Nurs Manag JT - Journal of nursing management JID - 9306050 SB - IM MH - Humans MH - *Infant, Very Low Birth Weight/physiology MH - Prospective Studies MH - Female MH - *Catheterization, Peripheral/methods/standards/instrumentation/statistics & numerical data MH - Infant, Newborn MH - Male PMC - PMC13396696 COIS- The authors declare no conflicts of interest. EDAT- 2026/07/24 06:35 MHDA- 2026/07/24 06:36 PMCR- 2026/07/23 CRDT- 2026/07/24 01:52 PHST- 2026/05/17 00:00 [revised] PHST- 2025/07/18 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/24 06:36 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 01:52 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - JONM2067769 [pii] AID - 10.1155/jonm/2067769 [doi] PST - ppublish SO - J Nurs Manag. 2026;2026(1):e2067769. doi: 10.1155/jonm/2067769. PMID- 42493851 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20260930 IS - 1440-1754 (Electronic) IS - 1034-4810 (Print) IS - 1034-4810 (Linking) VI - 62 IP - 9 DP - 2026 Sep TI - Investigating the Relationship Between Sensory Processing, Pain and Toe Walking Gait: A Survey Study. PG - 1682-1692 LID - 10.1111/jpc.70504 [doi] AB - AIM: This study aimed to examine sensory processing patterns, the frequency and impact of parent-reported pain in children who toe walk across a range of diagnoses using validated caregiver-report tools. METHODS: An online cross-sectional survey was distributed internationally between July 2024 and March 2025. Parents of children who toe walk aged 3-14 years, regardless of diagnosis, completed the Short Sensory Profile (SSP) and the Child Activity Limitations Interview-9 (CALI-9). RESULTS: The survey collected responses from 176 parents of 187 children with toe walking gait. Sensory processing challenges were frequently reported, particularly in children with autism spectrum disorder (98%). Nearly half (48% of 187) of children were reported to experience pain, most frequently in the feet/ankles, lower legs, and hips/thighs. Most parents (94%) and their child's medical professional (81%) attributed their child's pain to toe walking. Parents of children experiencing pain described significantly greater limitations in activities such as sports (OR 3.10, p < 0.001), running (OR 3.46, p < 0.001), and social participation (OR 2.43, p < 0.001). CONCLUSION: Sensory processing differences and pain were frequently reported among children who toe walk in this sample. Routine assessment of sensory processing and pain in clinical practice may guide targeted interventions to improve participation, function, and quality of life. CI - (c) 2026 The Author(s). Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Donne, Jack H AU - Donne JH AUID- ORCID: 0000-0002-8364-5079 AD - School of Primary and Allied Health Care, Monash University, Melbourne, Victoria, Australia. FAU - Pacey, Verity AU - Pacey V AD - School of Health Sciences and Nursing, Macquarie University, Sydney, New South Wales, Australia. FAU - Polt, Desiree AU - Polt D AD - Parent Team Member, Junction City, Kansas, USA. FAU - Powell, Jennifer A AU - Powell JA AD - School of Medicine, The University of Queensland, Brisbane, Australia. FAU - Fahey, Michael C AU - Fahey MC AUID- ORCID: 0000-0003-0811-4785 AD - Department of Paediatrics, Monash Health, Melbourne, Victoria, Australia. AD - Department of Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Williams, Cylie M AU - Williams CM AUID- ORCID: 0000-0002-0223-9141 AD - School of Primary and Allied Health Care, Monash University, Melbourne, Victoria, Australia. LA - eng PT - Journal Article DEP - 20260723 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - Male MH - Child, Preschool MH - *Toes MH - Surveys and Questionnaires MH - *Pain/physiopathology MH - *Gait/physiology MH - *Walking/physiology MH - Parents PMC - PMC13617236 OAB - Emerging evidence suggests that toe walking gait in children may be related to disrupted sensory processing abilities. Parents in this study frequently reported sensory processing challenges among children who toe walked, regardless of the reason for toe walking. Limited research has examined the prevalence or impact of pain in children who toe walk. In this study, almost half of the children were reported to experience pain, which was associated with limitations in activities such as sports, running, and social participation. Routine assessment of sensory processing and pain in clinical practice may guide targeted interventions aiming to improve participation, function, and quality of life. OABL- eng OTO - NOTNLM OT - paediatrics OT - pain OT - sensory processing OT - survey OT - toe walking COIS- The authors declare no conflicts of interest. EDAT- 2026/07/24 06:35 MHDA- 2026/09/28 05:33 PMCR- 2026/09/28 CRDT- 2026/07/24 00:13 PHST- 2026/06/23 00:00 [revised] PHST- 2026/03/02 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/09/28 05:33 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 00:13 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - JPC70504 [pii] AID - 10.1111/jpc.70504 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Sep;62(9):1682-1692. doi: 10.1111/jpc.70504. Epub 2026 Jul 23. PMID- 42492475 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260813 IS - 1872-7654 (Electronic) IS - 0301-2115 (Linking) VI - 325 DP - 2026 Sep TI - Association between first-trimester PAPP-A and large-for-gestational-age neonates in non-diabetic pregnancies: An exploratory cohort study. PG - 115308 LID - S0301-2115(26)00376-3 [pii] LID - 10.1016/j.ejogrb.2026.115308 [doi] AB - OBJECTIVE: To evaluate the predictive value of elevated first-trimester pregnancy-associated plasma protein-A (PAPP-A) for large-for-gestational-age (LGA) neonates in non-diabetic pregnancies, and to investigate its potential modifying effect on classical fetal-growth-restricting factors. METHODS: This retrospective cohort study analysed 563 normoglycaemic pregnancies, with strict exclusion of patients with gestational or pregestational diabetes. Participants were stratified by first-trimester PAPP-A percentile into high (>90th percentile, n = 73) and normal ( 90th percentile and continuous multiples of the median (MoM)] were adjusted for maternal age, body mass index, weight gain, smoking status, and fetal gender. Main outcomes included birth weight, LGA (>4000 g), neonatal length, and neonatal intensive care unit admission rate. RESULTS: High PAPP-A was significantly associated with higher mean birth weight (3388.2 +/- 526.4 g vs 3193.1 +/- 538.7 g; p = 0.004) and a 2.4-fold increase in the incidence of LGA (11.0% vs 4.5%; p = 0.044). PAPP-A MoM was positively correlated with neonatal crown-heel length (r = 0.132; p = 0.001). In the continuous multivariate model, every 1-unit increase in PAPP-A MoM was associated with a 1.82-fold increase [95% confidence interval (CI) 1.21-2.72; p = 0.003] in the risk of LGA. Receiver operating characteristic curve analysis showed an area under the curve of 0.665 (95% CI 0.566-0.762), with a high negative predictive value of 95.5% (95% CI 93.3-97.0%) but limited sensitivity (26.7%, 95% CI 14.2-44.4%) and positive predictive value (11.0%, 95% CI 5.7-20.2%). In exploratory subgroup analyses, high PAPP-A was associated with higher birth weight in the presence of factors such as advanced maternal age and limited weight gain. CONCLUSION: In non-diabetic pregnancies, elevated first-trimester PAPP-A is an independent correlate of fetal overgrowth. As a potential marker of increased free insulin-like growth factor bioavailability, high PAPP-A may reflect an anabolic signal that warrants further investigation in multiparametric prediction models. Its clinical utility as a standalone screening tool is currently limited by low sensitivity and a positive predictive value; therefore, its role remains to be established in larger prospective trials. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Karakaya, Turan Kaan AU - Karakaya TK AD - Department of Obstetrics and Gynaecology, Faculty of Medicine, Giresun University, Giresun, Turkey. Electronic address: kaan.karakaya@giresun.edu.tr. FAU - Arslan, Hilmi Furkan AU - Arslan HF AD - Department of Medical Biochemistry, Faculty of Medicine, Giresun University, Giresun, Turkey. LA - eng PT - Journal Article DEP - 20260716 PL - Ireland TA - Eur J Obstet Gynecol Reprod Biol JT - European journal of obstetrics, gynecology, and reproductive biology JID - 0375672 RN - EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A) RN - EC 3.4.24.79 (PAPPA protein, human) SB - IM MH - Humans MH - Female MH - *Pregnancy-Associated Plasma Protein-A/metabolism/analysis MH - Pregnancy MH - *Pregnancy Trimester, First/blood MH - *Infant, Large for Gestational Age MH - Retrospective Studies MH - Adult MH - Infant, Newborn MH - *Fetal Macrosomia/blood MH - Birth Weight MH - Predictive Value of Tests OTO - NOTNLM OT - Fetal macrosomia OT - Insulin-like growth factor (IGF) OT - Large for gestational age (LGA) OT - Pregnancy-associated plasma protein-A (PAPP-A) OT - Prenatal screening COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/24 00:37 MHDA- 2026/08/13 23:36 CRDT- 2026/07/23 18:11 PHST- 2026/03/04 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/13 23:36 [medline] PHST- 2026/07/24 00:37 [pubmed] PHST- 2026/07/23 18:11 [entrez] AID - S0301-2115(26)00376-3 [pii] AID - 10.1016/j.ejogrb.2026.115308 [doi] PST - ppublish SO - Eur J Obstet Gynecol Reprod Biol. 2026 Sep;325:115308. doi: 10.1016/j.ejogrb.2026.115308. Epub 2026 Jul 16. PMID- 42492456 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260828 IS - 1532-2688 (Electronic) IS - 1059-1311 (Linking) VI - 141 DP - 2026 Sep TI - Predicting the efficacy of classic ketogenic diet therapy in children with refractory epilepsy using dynamic changes in the glucose-ketone index (GKI). PG - 137-142 LID - S1059-1311(26)00208-6 [pii] LID - 10.1016/j.seizure.2026.07.011 [doi] AB - OBJECTIVE: To investigate the predictive value of dynamic changes in blood glucose, blood ketones and glucose-ketone index (GKI) for the efficacy of the classic ketogenic diet (CKD)in children with refractory epilepsy. METHODS: Data from 189 children with refractory epilepsy who received classic ketogenic diet (CKD) between January 2018 and December 2024 were retrospectively analyzed. Blood glucose, blood ketones and the glucose-ketone index (GKI) which defined as the ratio of blood glucose to blood ketone were monitored at multiple time points, from the 2-day period of halving carbohydrate intake to 90 days after CKD initiation. Patients were divided into a responder group (>/=50% seizure reduction) and a non-responder group based on Engel's classification after three months of treatment. Group differences in metabolic indices were assessed, and receiver operating characteristic (ROC) analysis identified optimal GKI thresholds for predicting response. RESULTS: On the first day of CKD therapy, GKI (AUC = 0.638) was the best single predictor of efficacy among all time points, with a cut-off value of 9.63 (sensitivity and specificity both 0.63). Combining blood glucose (<4.95 mmol/L) and blood ketone (>0.75 mmol/L) levels improved predictive performance (AUC = 0.661). CONCLUSION: A GKI > 9.63 on the first day of CKD therapy may serve as an early-warning indicator of poor treatment response. The early treatment phase-from the second day of halving carbohydrate intake to the first day of CKD-represents a critical window for metabolic transition. Monitoring dynamic changes in GKI and blood ketone may facilitate timely adjustment of intervention strategies. CI - Copyright (c) 2026 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. FAU - Li, Jiang AU - Li J AD - Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, 410007, China. FAU - Wang, Tianqi AU - Wang T AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Yu, Lifei AU - Yu L AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. Electronic address: yulf_ek@fudan.edu.cn. FAU - Ni, Yan AU - Ni Y AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Li, Yijie AU - Li Y AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Zhang, Yunjian AU - Zhang Y AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Zhou, Shuizhen AU - Zhou S AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Wang, Yi AU - Wang Y AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. LA - eng PT - Journal Article DEP - 20260712 PL - England TA - Seizure JT - Seizure JID - 9306979 RN - 0 (Ketones) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - *Drug Resistant Epilepsy/diet therapy/blood MH - *Ketones/blood MH - Female MH - *Blood Glucose/metabolism MH - Retrospective Studies MH - Male MH - Child MH - Treatment Outcome MH - Child, Preschool MH - Adolescent OTO - NOTNLM OT - Blood ketone OT - CKD OT - Children with refractory epilepsy OT - Classic ketogenic diet OT - Efficacy prediction OT - GKI COIS- Declaration of competing interest All authors declare no competing interests. EDAT- 2026/07/24 00:37 MHDA- 2026/08/28 23:34 CRDT- 2026/07/23 18:10 PHST- 2026/04/26 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/08/28 23:34 [medline] PHST- 2026/07/24 00:37 [pubmed] PHST- 2026/07/23 18:10 [entrez] AID - S1059-1311(26)00208-6 [pii] AID - 10.1016/j.seizure.2026.07.011 [doi] PST - ppublish SO - Seizure. 2026 Sep;141:137-142. doi: 10.1016/j.seizure.2026.07.011. Epub 2026 Jul 12. PMID- 42492233 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 1530-0315 (Electronic) IS - 0195-9131 (Linking) VI - 58 IP - 11 DP - 2026 Nov 1 TI - Resting Metabolic Rate in Collegiate Male Wrestlers: Cross-Validation and Development of Prediction Equations. PG - 2524-2534 LID - 10.1249/MSS.0000000000004071 [doi] AB - PURPOSE: The purpose of the current study was to cross-validate previously developed resting metabolic rate (RMR) prediction equations using laboratory measurements of RMR as a criterion. METHODS: National Collegiate Athletic Association Division I (n = 60) and III (n = 113) male wrestlers participated in the current study (n = 173; Age: 19.6 +/- 1.5 yrs.; Height: 176.3 +/- 6.3 cm; Weight: 76.6 +/- 10.9 kg; Body Fat: 11.4 +/- 3.0%). Indirect calorimetry was used to measure RMR and Skinfold thickness was used to estimate body fat percentage (BF%) during the preseason period under standardized dress (underwear only), fasting, and resting conditions. RESULTS: Mean measured RMR was 2102 +/- 341 kcal.d -1 . All body mass-based RMR prediction equations significantly underestimated the measured RMR, with the exception of the Jagim and Schofield equations. The Tinsley fat-free mass (FFM) equation and the Cunningham equation had the lowest constant error values when compared with measured RMR (mean bias +/- standard error: 80 +/- 20 kcal and 126 +/- 20 kcal.d -1 , respectively). Linear regression indicated the Tinsley FFM (R 2 = 0.422, root-mean-squared error (RMSE) = 279 kcals, %RMSE = 13.3%), and Cunningham FFM equations had the closest agreement to measured RMR (R 2 = 0.422, RMSE = 301 kcals, %RMSE = 14.3%), along with the Jagim equation for a body mass-based prediction equation (R 2 = 0.377, RMSE = 338 kcals, %RMSE = 16.1%). The standard error of the estimate (SEE) ranged from 260 to 272 kcal.d -1 across equations. Coefficients of determination (R 2 ) ranged from 37% to 42%. The new body mass and FFM-based equations exhibited good agreement based on the constant error (26 and -13 kcal.d -1 ), RMSE (274 and 252 kcal.d -1 ), respectively. CONCLUSIONS: The newly developed equations demonstrated mean bias <2% of measured RMR. CI - Copyright (c) 2026 by the American College of Sports Medicine. FAU - Jagim, Andrew R AU - Jagim AR AD - Health Professions, University of Wisconsin-La Crosse, La Crosse, WI. AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. FAU - Dobbs, Ward C AU - Dobbs WC AD - Division of Kinesiology and Health, University of Wyoming, Laramie, WY. FAU - Magee, Meghan K AU - Magee MK AD - Exercise Science and Exercise Physiology, Kent State University, Kent, OH. FAU - Fields, Jennifer B AU - Fields JB AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. AD - Nutritional Sciences, University of Connecticut, Storrs, CT. FAU - Sims, Jesse N L AU - Sims JNL AD - Exercise Science and Exercise Physiology, Kent State University, Kent, OH. FAU - Saine, Noelle D AU - Saine ND AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. AD - Sport, Recreation, and Tourism Management, George Mason University, Manassas, VA. FAU - Jones, Margaret T AU - Jones MT AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. AD - Sport, Recreation, and Tourism Management, George Mason University, Manassas, VA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260703 PL - United States TA - Med Sci Sports Exerc JT - Medicine and science in sports and exercise JID - 8005433 SB - IM MH - Humans MH - *Basal Metabolism/physiology MH - *Wrestling/physiology MH - Male MH - Calorimetry, Indirect MH - Young Adult MH - Skinfold Thickness MH - Body Composition MH - Prediction Methods, Machine MH - Adolescent MH - Body Mass Index OTO - NOTNLM OT - BODY COMPOSITION OT - ENERGY REQUIREMENTS OT - METABOLISM OT - WEIGHT MANAGEMENT OT - WRESTLING EDAT- 2026/07/24 00:37 MHDA- 2026/10/14 05:33 CRDT- 2026/07/23 18:03 PHST- 2026/10/14 05:33 [medline] PHST- 2026/07/24 00:37 [pubmed] PHST- 2026/07/23 18:03 [entrez] AID - 00005768-990000000-01108 [pii] AID - 10.1249/MSS.0000000000004071 [doi] PST - ppublish SO - Med Sci Sports Exerc. 2026 Nov 1;58(11):2524-2534. doi: 10.1249/MSS.0000000000004071. Epub 2026 Jul 3. PMID- 42491911 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Associations between echocardiographic parameters and aerobic performance in young athletes. PG - e21263 LID - 10.7717/peerj.21263 [doi] LID - e21263 AB - BACKGROUND AND OBJECTIVES: Cardiac morphology can be shaped according to chronic and acute exercise and provides important findings regarding cardiac response to different types of performance. However, cardiac remodelling is a multidimensional process involving intertwined structural, functional, and haemodynamic components, making it difficult to explain with a single criterion and requiring a comprehensive assessment. The aim of this study is to investigate the effects of echocardiographic (ECHO) parameters on 30-15 interval fitness test (IFT) performance. MATERIALS AND METHODS: Twenty-three active athletes participated in the study. All ECHO measurements were performed by a specialist cardiologist using standard clinical methods, and the IFT was administered to participants after the measurements. In the analysis, ECHO variables representing the structural characteristics of the left ventricle, systolic-diastolic function, and aortic/atrial measurements were evaluated, with priority given to parameters indexed according to body surface area (BSA). Relationships between IFT performance and ECHO parameters were examined by establishing parsimonious linear regression models appropriate for small sample sizes; models were evaluated using Akaike Information Criterion (AICc)-based model comparison and model averaging, results were checked for robustness using leave-one-out cross-validation (LOOCV), and the SHapley Additive exPlanations (SHAP) approach, consistent with the model, was used for interpretability. RESULTS: In the AICc-based model comparison, the parsimonious model with the highest support consisted of the body composition (BMI) + posterior wall (PW)_I + aortic strain (AORT_STR) components and explained approximately 46% of the variance in IFT performance (mean adj. R (2) = 0.461; LOOCV root mean squared error (RMSE) = 1.811; mean DeltaAICc = 0; mean Akaike weight = 0.0476). Variable importance analyses in the best model set revealed that the variables most consistently associated with IFT were BMI (Sigmaw = 0.46; weighted mean-SHAP- = 0.154; beta = - 0.068) and posterior wall thickness indexed by BSA (PW_I) (Sigmaw = 0.35; weighted mean-SHAP- = 0.211; beta = 0.348). This was followed by IVS_I (Sigmaw = 0.191; weighted mean-SHAP- = 0.072; beta = 0.124), A wave (Sigmaw = 0.177; weighted mean-SHAP- = 0.080; beta = 0.849) and AORT_STR (Sigmaw = 0.166; weighted mean-SHAP- = 0.077; beta = 0.013) followed. Overall, the distribution of model weights across multiple models indicated significant model uncertainty, while BMI and indexed structural measures provided the strongest and most consistent signal in relation to IFT. CONCLUSIONS: In this context, it has been concluded that body composition is also a determining factor in the relationship between cardiac morphology and IFT performance. Large prospective studies are important for determining this complex relationship. CI - (c)2026 Akgumus et al. FAU - Akgumus, Alkame AU - Akgumus A AD - Department of Cardiology, Medical Faculty, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Kurtoglu, Ahmet AU - Kurtoglu A AD - Department of Coaching Education, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Ozer, Omer AU - Ozer O AD - Department of Physical Education and Sport Teaching, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Duygu, Ali AU - Duygu A AD - Department of Cardiology, Medical Faculty, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Car, Bekir AU - Car B AD - Department of Physical Education and Sport Teaching, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Kurtoglu, Ertugrul AU - Kurtoglu E AD - Department of Cardiology, Medical Faculty, Malatya Turgut Ozal University, Malatya, Turkey. FAU - Uzgur, Kamil AU - Uzgur K AD - Department of Coaching Education, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Er, Fahri AU - Er F AD - Department of Cardiology, Medical Faculty, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Muracki, Jaroslaw AU - Muracki J AD - Institute of Physical Culture Sciences, Department of Physical Culture and Health, University of Szczecin, Szczecin, Poland. FAU - Elkholi, Safaa M AU - Elkholi SM AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Echocardiography MH - Male MH - *Athletes MH - Young Adult MH - Female MH - *Exercise/physiology MH - Adolescent MH - Ventricular Function, Left/physiology MH - Exercise Test MH - Heart Ventricles/diagnostic imaging MH - *Athletic Performance/physiology PMC - PMC13378464 OTO - NOTNLM OT - Aerobic performance OT - Cardiac function OT - Cardiac morphology OT - Echocardiography COIS- The authors declare there are no competing interests. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/14 CRDT- 2026/07/23 16:18 PHST- 2025/10/03 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 16:18 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 21263 [pii] AID - 10.7717/peerj.21263 [doi] PST - epublish SO - PeerJ. 2026 Jul 14;14:e21263. doi: 10.7717/peerj.21263. eCollection 2026. PMID- 42491750 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 2214-9996 (Electronic) IS - 2214-9996 (Linking) VI - 92 IP - 1 DP - 2026 TI - Implementing a WASH Package Within Prevention of Vertical Transmission of HIV Programming in Lilongwe, Malawi: A Program Evaluation. PG - 64 LID - 10.5334/aogh.5322 [doi] LID - 64 AB - Background: Access to safe drinking water is a considerable problem in Malawi. Contaminated water plays a major role in diarrheal disease, particularly for people living with HIV and their families. Water, sanitation, and hygiene (WASH) interventions can reduce the risk of diarrhea among children by up to 50%. However, few published reports describe WASH integration in routine HIV care programming in Africa. Objective: To evaluate a WASH program integrated within the prevention of vertical transmission of HIV (PVTH) care in Lilongwe, Malawi. Methods: The University of North Carolina's Project Malawi, the Proctor & Gamble Company (P&G), and the Malawi Ministry of Health implemented a safe drinking water program from 2008 to 2023, integrated within the national PVTH program in Lilongwe, Malawi. We provided a point-of-use WASH package to pregnant and breastfeeding women (PBFW) with HIV and their families that included soap, sieves, closed-water containers, and P&G water purification packets. We examine program impact by describing trends in childhood diarrhea and retention in care at 33 program facilities and 29 non-program facilities from 2018 to 2022. Findings: Over the program's final 5 years, an estimated 2 million water purification packets were distributed annually. From 2018 to 2022 in program facilities, non-bloody diarrhea rates among children under 5 years remained constant, while bloody-diarrhea rates fell at both program and non-program facilities. A small association was found between facility participation in the program and retention in care among PBFW living with HIV (incidence rate ratio: 1.05, 95% CI: 0.99-1.12), but of borderline statistical significance. Conclusions: In an environment where access to clean water is not assured, we demonstrated the feasibility of delivering a WASH package in HIV care settings over 15 consecutive years. The collaboration between government, academic, and industry partners provides an example for how to integrate WASH within PVTH programming. CI - Copyright: (c) 2026 The Author(s). FAU - Topazian, Hillary M AU - Topazian HM AUID- ORCID: 0000-0001-7824-9605 AD - University of Utah, Salt Lake City, United States. FAU - Noble, Skyler AU - Noble S AD - University of North Carolina, Chapel Hill, United States. FAU - Mofolo, Innocent AU - Mofolo I AD - UNC Project, Lilongwe, Malawi. FAU - Mwale, Gertrude AU - Mwale G AD - UNC Project, Lilongwe, Malawi. FAU - Phanga, Twambilie AU - Phanga T AD - UNC Project, Lilongwe, Malawi. FAU - Hoffman, Irving F AU - Hoffman IF AD - University of North Carolina, Chapel Hill, United States. AD - UNC Project, Lilongwe, Malawi. FAU - Herce, Michael E AU - Herce ME AD - University of North Carolina, Chapel Hill, United States. AD - UNC Project, Lilongwe, Malawi. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - Ann Glob Health JT - Annals of global health JID - 101620864 RN - 0 (Drinking Water) RN - 0 (Soaps) SB - IM MH - Humans MH - Malawi/epidemiology MH - *Infectious Disease Transmission, Vertical/prevention & control MH - *HIV Infections/prevention & control/transmission MH - Female MH - Program Evaluation MH - *Sanitation/methods MH - Pregnancy MH - *Hygiene MH - Drinking Water MH - *Diarrhea/prevention & control/epidemiology MH - Infant MH - *Water Purification/methods MH - Water Supply MH - Breast Feeding MH - Soaps MH - Infant, Newborn PMC - PMC13378426 OTO - NOTNLM OT - WASH OT - hygiene OT - prevention of vertical transmission of HIV OT - program implementation OT - sanitation OT - water COIS- The authors have no competing interests to declare. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/14 CRDT- 2026/07/23 16:14 PHST- 2026/04/21 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 16:14 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.5334/aogh.5322 [doi] PST - epublish SO - Ann Glob Health. 2026 Jul 14;92(1):64. doi: 10.5334/aogh.5322. eCollection 2026. PMID- 42491719 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260922 IS - 2632-1297 (Electronic) IS - 2632-1297 (Linking) VI - 8 IP - 4 DP - 2026 TI - Using reference intervals to improve interpretation of youth sport-related concussion biomarkers using a research platform. PG - fcag250 LID - 10.1093/braincomms/fcag250 [doi] LID - fcag250 AB - Youth sports-related concussion (SRC) is a major health concern. Approximately 67% of Canadian youth participate in sports and recreation, and 93% of head injuries experienced in sports and recreation are concussions. SRCs are challenging to diagnose because symptoms are often subtle, which can affect the reliability of clinical diagnostic methods that are often subjective. As undiagnosed concussions can potentially lead to unfavourable neurological implications, objective diagnostic tools have the potential to improve diagnosis and inform prognosis. Recent research has highlighted the potential utility of plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) for SRC diagnosis, offering a quantitative and cost-effective diagnostic method. However, a major gap in the literature is understanding whether the magnitude of change in NfL and GFAP levels post-SRC exceeds normal variation observed at the population level. This study evaluates NfL and GFAP as diagnostic SRC biomarkers by comparing preseason and post-SRC levels measured up to 28 days after injury to population-based reference intervals. Preseason (uninjured) and post-SRC plasma samples from the Surveillance in High Schools and Community Sports to Reduce Concussions and their Consequences study were quantified with Quanterix's Neurology-4-plex-B assay and compared to previously generated age-matched reference interval. A total of 658 preseason specimens (440 male [67%]; median [range] age, 15.9 [10.4-18.4] years) and 134 post-SRC specimens (72 male [54%]; median [range] age, 16.1 [11.2-18.4] years) were assessed. Median biomarker levels were higher at post-SRC than preseason for both NfL (preseason/post-SRC = 5.1/5.5 pg/ml, P = 0.0339) and GFAP (preseason/post-SRC=51.7/59.7 pg/ml, P < 0.0001). However, when compared to population controls across the same age range, 580 (88%) preseason and 119 (89%) of post-SRC measures fell within the reference interval (5th-95th percentile) for NfL and 644 (98%) preseason and 132 (99%) of post-SRC measures fell within the reference interval for GFAP. Further, the number of participants within or above the reference interval (>95th percentile) did not differ between preseason and post-SRC groups for either NfL (P > 0.9999) or GFAP (P > 0.9999). Body mass index was inversely associated with the distribution of NfL (5th-50th/50th-95th = 23.02/22.15, P = 0.0083; 5th-50th/50th-95th = 24.37/21.74, P = 0.0038) and GFAP (5th-50th/50th-95th = 23.12/22.29, P = 0.0219; 5th-50th/50th-95th = 25.03/22.27, P = 0.0025) within the reference interval, which may explain the skew of NfL and GFAP levels in the SHRed participants compared to population controls at both preseason and post-SRC. We conclude that plasma NfL and GFAP measured up to 28 days post-SRC do not meet criteria for clinical significance as stand-alone post-acute diagnostic biomarkers for adolescent SRC. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Guarantors of Brain. FAU - Achalu, Kidus AU - Achalu K AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Cooper, Jennifer G AU - Cooper JG AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Tabor, Jason B AU - Tabor JB AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Ghodsi, Mohammad AU - Ghodsi M AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Huang, Johnny AU - Huang J AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Josafatow-Garcia, Nik AU - Josafatow-Garcia N AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Penner, Linden C AU - Penner LC AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Stukas, Sophie AU - Stukas S AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Galarneau, Jean-Michel AU - Galarneau JM AUID- ORCID: 0000-0003-3784-8753 AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Fraser, Douglas D AU - Fraser DD AD - Department of Pediatrics and Clinical Neurological Sciences, Western University, London, Ontario N6A 3K7, Canada. FAU - Smirl, Jonathan AU - Smirl J AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Yeates, Keith O AU - Yeates KO AUID- ORCID: 0000-0001-7680-2892 AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Department of Psychology, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Debert, Chantel T AU - Debert CT AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Emery, Carolyn A AU - Emery CA AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Departments of Pediatrics and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Wellington, Cheryl L AU - Wellington CL AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. LA - eng PT - Journal Article DEP - 20260705 PL - England TA - Brain Commun JT - Brain communications JID - 101755125 PMC - PMC13378169 OTO - NOTNLM OT - blood-based biomarkers OT - concussion OT - context of use OT - normative data COIS- Cheryl Wellington is principal investigator on unrelated operating grants from the Canadian Institutes of Health Research, Weston Brain Institutes, Cure Alzheimer Fund, US Department of Defence, and the National Institutes of Health. Keith Owen Yeates is principal investigator on a grant from the Canada Foundation for Innovation; co-investigator on grants from the Canadian Institutes of Health Research, Brain Canada Foundation, and Ontario Brain Institute; a paid research consultant for the Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; receives book royalties from Guilford Press and Cambridge University Press; has received travel support and honorariums for presentations to multiple organizations; and serves on the Data Safety and Monitoring Board for the Concussion Health Improvement Program (CHIP) Trial, University of Washington. All other authors report no competing interests. EDAT- 2026/07/23 18:34 MHDA- 2026/07/23 18:35 PMCR- 2026/07/05 CRDT- 2026/07/23 16:13 PHST- 2025/05/02 00:00 [received] PHST- 2026/04/23 00:00 [revised] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/07/23 18:35 [medline] PHST- 2026/07/23 18:34 [pubmed] PHST- 2026/07/23 16:13 [entrez] PHST- 2026/07/05 00:00 [pmc-release] AID - fcag250 [pii] AID - 10.1093/braincomms/fcag250 [doi] PST - epublish SO - Brain Commun. 2026 Jul 5;8(4):fcag250. doi: 10.1093/braincomms/fcag250. eCollection 2026. PMID- 42491691 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260813 IS - 2474-0527 (Electronic) IS - 2474-0527 (Linking) VI - 10 IP - 1 DP - 2026 TI - Pain Rehabilitation Virtual Reality (PR-VR) at Home: A Pilot Randomized Controlled Trial for Youth with Chronic Pain. PG - 2683648 LID - 10.1080/24740527.2026.2683648 [doi] LID - 2683648 AB - BACKGROUND: Pain Rehabilitation Virtual Reality (PR-VR) is a novel tool designed to engage youth with chronic pain in exercise as a part of physiotherapy. PR-VR has been evaluated in day-treatment and outpatient settings, but not for at home use. AIMS: To evaluate the feasibility, acceptability and safety of PR-VR at home for youth with chronic pain. An exploratory aim evaluated the preliminary effectiveness of PR-VR on pain and disability. METHODS: This was a 3-arm pilot randomized controlled trial (registration #NCT04912817). Each study arm included four 60-min physiotherapy sessions via Zoom (1: commercially available VR; 2: custom-developed PR-VR; 3: standard physiotherapy care). Feasibility metrics included enrollment, accrual, and drop-out rates. Acceptability was measured via satisfaction surveys and qualitative interviews. Pain and disability were measured via self-report, physical performance, and actigraphy. RESULTS: Thirty-seven of 70 eligible patients approached were enrolled and randomized (53% enrollment rate, 100% accrual rate), including 28 females (76%) aged 10-17 years. Twenty-eight participants completed the study (33% drop-out rate; reasons include pain resolution, medical complexity, dissatisfaction with assignment to control). Ten minor adverse events were reported across study arms. Participants and physiotherapists expressed high levels of VR acceptability. Of the participants who completed arms 1 and 2 (n = 17), 94% were satisfied/very satisfied with VR and 100% rated VR as easy/very easy to use. CONCLUSIONS: Results from this study demonstrate the safety and acceptability of VR in pediatric pain rehabilitation. These feasibility results will inform the design of future large-scale trials, including consideration of a wait-list control group. TRIAL REGISTRATION: ClinicalTrials.gov, NCT04912817. CI - (c) 2026 The Author(s). Published with license by Taylor & Francis Group, LLC. FAU - Mesaroli, Giulia AU - Mesaroli G AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. AD - Department of Rehabilitation Services, The Hospital for Sick Children, Toronto, Canada. AD - Department of Physical Therapy, University of Toronto, Toronto, Canada. FAU - Xi, Richard AU - Xi R AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. FAU - Hroch Tiessen, Petra AU - Hroch Tiessen P AD - Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada. FAU - Kurup, Uttara AU - Kurup U AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. FAU - Nishat, Fareha AU - Nishat F AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. FAU - Killackey, Tieghan AU - Killackey T AD - Peter Munk Cardiac Centre, University Health Network, Toronto, Canada. AD - Lawrence Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada. FAU - Sucha, Ewa AU - Sucha E AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. FAU - Simons, Laura E AU - Simons LE AD - Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, USA. FAU - Stephens, Samantha AU - Stephens S AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. FAU - Campbell, Fiona AU - Campbell F AD - Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada. AD - Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. FAU - Stinson, Jennifer AU - Stinson J AUID- ORCID: 0000-0002-9969-8052 AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. AD - Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada. AD - Lawrence Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada. LA - eng SI - ClinicalTrials.gov/NCT04912817 PT - Journal Article DEP - 20260716 PL - United States TA - Can J Pain JT - Canadian journal of pain = Revue canadienne de la douleur JID - 101720589 PMC - PMC13378713 OTO - NOTNLM OT - Virtual reality OT - chronic pain OT - pediatric OT - physiotherapy OT - rehabilitation COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/16 CRDT- 2026/07/23 16:12 PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 16:12 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - 2683648 [pii] AID - 10.1080/24740527.2026.2683648 [doi] PST - epublish SO - Can J Pain. 2026 Jul 16;10(1):2683648. doi: 10.1080/24740527.2026.2683648. eCollection 2026. PMID- 42491300 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260813 IS - 2673-6217 (Electronic) IS - 2673-6217 (Print) IS - 2673-6217 (Linking) VI - 7 DP - 2026 TI - Effects of an 8-month intergenerational adapted taekwondo training on functional fitness in senior novice practitioners. PG - 1849400 LID - 10.3389/fragi.2026.1849400 [doi] LID - 1849400 AB - BACKGROUND: Aging is commonly associated with declines in functional fitness that can be effectively attenuated through mid-to long-term, multifaceted physical activity. However, physical activity performed by older adults often aims to maintain, rather than improve, physical fitness. Martial arts are increasingly recognized as suitable multimodal interventions for older adults, as they integrate balance, flexibility, motor control, and cognitive engagement. Within this framework, taekwondo may represent a feasible activity to preserve and enhance functional fitness. Moreover, intergenerational approaches (combining younger and older participants in shared training sessions) may further support adherence, motivation, and social-cognitive stimulation. Despite this potential, long-term programs involving novice older adults remain largely unexplored. Therefore, this study aimed to evaluate the effect of an 8-month intergenerational adapted taekwondo training program for older novice practitioners. METHODS: This single-arm pre-post observational study used a volunteer convenience sample without a control group. Twenty-one seniors (14 females and 7 males: 63-83 years) participated twice-weekly 60-min taekwondo training for 8 months with one weekly session performed together with 21 children (6-13 years). The "American Alliance for Health, Physical Education, Recreation, and Dance" test battery was used to assess the seniors' functional fitness before and after the intervention based on flexibility, upper-body strength, aerobic endurance, agility/dynamic balance, and coordination. Linear mixed-effects models for repeated measures examined time and sex effects. RESULTS: Significant (p < 0.05) improvements were observed in aerobic endurance and coordination, with normative compliance increasing from 14.3% to 33.3% and from 66.7% to 95.2%, respectively. No significant changes were found in upper body strength, agility/dynamic, or flexibility, though males outperformed females in the Chair sit-and-reach and endurance tests. DISCUSSION: Despite the limited sample size and the lack of a control group, which limit causal inference and generalizability, the program was associated with improvements in selected functional fitness domains, particularly aerobic endurance and coordination, whereas flexibility, agility/dynamic balance, and upper-body strength did not change significantly, suggesting that intergenerational adapted taekwondo may represent a feasible long-term physical activity option for novice older adults. CI - Copyright (c) 2026 Di Rocco, Perazzetti, Festino, Papale, Ciaccioni, Fuchs, Del Duca, Chiodo, Capranica, Cortis and Fusco. FAU - Di Rocco, Francesca AU - Di Rocco F AD - Department of Human Sciences, Society and Health, University of Cassino and Lazio Meridionale, Cassino, Italy. AD - European University of Technology EUt+, Cassino, Italy. AD - Department of Human Sciences and Promotion of Quality of Life, "San Raffaele" Open University of Rome, Rome, Italy. FAU - Perazzetti, Andrea AU - Perazzetti A AD - Degree Course in Sciences of Motor Activities, Sports and Psychomotor Education, Faculty of Law, Telematic University Giustino Fortunato, Benevento, Italy. FAU - Festino, Emanuel AU - Festino E AD - Department of Human Sciences, Society and Health, University of Cassino and Lazio Meridionale, Cassino, Italy. AD - European University of Technology EUt+, Cassino, Italy. FAU - Papale, Olga AU - Papale O AD - Department of Human Sciences, Society and Health, University of Cassino and Lazio Meridionale, Cassino, Italy. AD - European University of Technology EUt+, Cassino, Italy. FAU - Ciaccioni, Simone AU - Ciaccioni S AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. FAU - Fuchs, Philip X AU - Fuchs PX AD - Department of Physical Education and Sports Sciences, National Taiwan Normal University, Taipei, Taiwan. FAU - Del Duca, Veronica AU - Del Duca V AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. FAU - Chiodo, Salvatore AU - Chiodo S AD - Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, Catanzaro, Italy. AD - Italian Taekwondo Federation (FITA), Rome, Italy. FAU - Capranica, Laura AU - Capranica L AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. FAU - Cortis, Cristina AU - Cortis C AD - Department of Human Sciences, Society and Health, University of Cassino and Lazio Meridionale, Cassino, Italy. AD - European University of Technology EUt+, Cassino, Italy. FAU - Fusco, Andrea AU - Fusco A AD - Department of Medicine and Aging Sciences, University of "G. D'Annunzio" Chieti-Pescara, Chieti, Italy. LA - eng PT - Journal Article DEP - 20260703 PL - Switzerland TA - Front Aging JT - Frontiers in aging JID - 9918231199706676 PMC - PMC13377424 OTO - NOTNLM OT - combat sports OT - elderly OT - martial arts OT - older adults OT - physical activity COIS- Author SC was employed by the company Italian Taekwondo Federation (FITA). The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/23 18:34 MHDA- 2026/07/23 18:35 PMCR- 2026/07/03 CRDT- 2026/07/23 16:01 PHST- 2026/04/07 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/23 18:35 [medline] PHST- 2026/07/23 18:34 [pubmed] PHST- 2026/07/23 16:01 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - 1849400 [pii] AID - 10.3389/fragi.2026.1849400 [doi] PST - epublish SO - Front Aging. 2026 Jul 3;7:1849400. doi: 10.3389/fragi.2026.1849400. eCollection 2026. PMID- 42491065 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260813 IS - 1943-8141 (Print) IS - 1943-8141 (Electronic) IS - 1943-8141 (Linking) VI - 18 IP - 6 DP - 2026 TI - Vitamin D +Docosahexaenoic acid supplementation: effects on serum markers and symptoms in ADHD children. PG - 4753-4764 LID - 10.62347/VDPV7251 [doi] AB - OBJECTIVE: To investigate the effect of vitamin D combined with Docosahexaenoic acid (DHA) supplementation on serum indicators, clinical symptoms and disease severity in children with attention deficit hyperactivity disorder (ADHD), and identify independent risk factors for treatment efficacy. METHODS: A retrospective analysis was performed on 367 children with ADHD admitted from August 2020 to August 2024, divided into control group (routine behavioral education + atomoxetine hydrochloride, n=180) and nutritional intervention (NI) group (additional vitamin D + DHA, n=187). The sample was split into training set (n=256) and validation set (n=111) at a 7:3 ratio, with relevant indicators analyzed via logistic regression, nomogram and ROC curve. RESULTS: After 3 months of treatment, the NI group had significantly lower ADHD Rating Scale IV (ADHD-RS-IV) and Clinical Global Impression Scale-Severity (CGI-S) scores, higher serum 25-hydroxyvitamin D [25(OH)D] and ferritin (SF) levels, higher total effective rate (94.49% vs 82.95%, P=0.004), and lower adverse reaction rate (4.72% vs 13.18%, P=0.018) than the control group (all P<0.05). Baseline ADHD-RS-IV>/=26.5 points, CGI-S>/=4.5 points, 25(OH)D<14.26 ng/mL and SF<19.61 ng/mL were independent risk factors for poor efficacy; their combined detection had an Area Under the Curve (AUC) of 0.901 in the validation set. CONCLUSION: Vitamin D combined with DHA can improve clinical symptoms, serum nutritional indicators, efficacy and safety of ADHD children. The 4 indicators are key factors affecting efficacy, and their combined detection has more accurate diagnostic efficiency. CI - AJTR Copyright (c) 2026. FAU - Cai, Jianying AU - Cai J AD - Department of Child Healthcare, Baoji Maternal and Child Health Hospital East Section of Jing'er Road, Weibin District, Baoji 721000, Shaanxi, China. FAU - Liu, Yuan AU - Liu Y AD - Department of Pediatric Infectious Diseases, Baoji Maternal and Child Health Hospital East Section of Jing'er Road, Weibin District, Baoji 721000, Shaanxi, China. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Am J Transl Res JT - American journal of translational research JID - 101493030 PMC - PMC13375999 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - Vitamin D OT - attention deficit hyperactivity disorder OT - docosahexaenoic acid OT - serum ferritin COIS- None. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/06/15 CRDT- 2026/07/23 15:55 PHST- 2026/01/22 00:00 [received] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 15:55 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.62347/VDPV7251 [doi] PST - epublish SO - Am J Transl Res. 2026 Jun 15;18(6):4753-4764. doi: 10.62347/VDPV7251. eCollection 2026. PMID- 42490625 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 1549-1676 (Electronic) IS - 1549-1277 (Print) IS - 1549-1277 (Linking) VI - 23 IP - 7 DP - 2026 Jul TI - Exploring parental prenatal influences on child health: A multicohort study and data visualisation tool. PG - e1005153 LID - 10.1371/journal.pmed.1005153 [doi] LID - e1005153 AB - BACKGROUND: The Developmental Origins of Health and Disease (DOHaD) hypothesis suggests that early life environmental exposures, especially during pregnancy, can impact long-term health. Research has largely relied on correlational evidence and has focussed on maternal factors, with less attention given to paternal, postnatal, and broader social determinants. This focus could complicate efforts to determine the most effective strategies for improving population health. METHODS AND FINDINGS: Using harmonised data across four population-based longitudinal cohort studies from the UK and Norway (births between 1991 and 2008), we took a systematic approach to explore associations of parental prenatal health behaviours (smoking, alcohol, and caffeine consumption) and low socioeconomic position (SEP) with 72 child health-related outcomes (e.g., related to body size and composition, cognitive function, mental health, blood pressure, allergy, etc.) from birth up to age 11. Where possible, cohort estimates were meta-analysed, yielding a maximum sample size of 232,139. We triangulated evidence of causality using different analytical approaches, including a Mendelian randomisation-informed approach using genetic risk scores, negative controls (maternal versus paternal and during versus post-pregnancy comparisons), and dose-response analyses. This comprehensive set of analyses generated more than 594,000 effect estimates. We developed a web app, 'EPoCH Explorer' to visualise and share our results in an accessible format. We did not find strong evidence for widespread or large effects of parental health behaviours on child health and wellbeing. Only 6% of analyses had a Cohen's D value >0.2 and FDR-adjusted P < 0.05. In most analyses, the effect estimate was similar for mothers and partners, with 51% showing a larger effect for mothers and 49% for partners. Despite the lack of widespread associations, we found consistent evidence of association between maternal smoking and small for gestational age, higher childhood body mass index (BMI), depressive symptoms, and behavioural issues, while partner smoking was consistently associated with childhood BMI and social communication difficulties. Overall, we found stronger evidence of child outcomes being associated with low SEP than with health behaviours: 15% of results for low SEP had a Cohen's D value >0.2 and FDR-P < 0.05, compared to 6% for parental smoking, 3% for alcohol, and 0.4% for caffeine. Sample sizes and statistical power varied across outcomes and there was limited ethnic diversity in our study samples. CONCLUSION: Our findings suggest that wider familial socioeconomic conditions may be a more important determinant of child health than specific parental health behaviours prenatally. Interventions to improve population health may be most effective if they target wider social inequalities, rather than individual behaviours and mothers specifically. We encourage researchers to use EPoCH Explorer to prioritise associations for exploration in their own datasets, thus enabling replication and cross-context comparison to validate and extend the generalisability of our findings. CI - Copyright: (c) 2026 Sharp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sharp, Gemma C AU - Sharp GC AUID- ORCID: 0000-0003-2906-4035 AD - School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. FAU - Lawlor, Deborah A AU - Lawlor DA AUID- ORCID: 0000-0002-6793-2262 AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Easey, Kayleigh E AU - Easey KE AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - School of Psychological Science, University of Bristol, Bristol, United Kingdom. FAU - Kundu, Sampurna AU - Kundu S AD - School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. FAU - Elhakeem, Ahmed AU - Elhakeem A AD - School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Hone, Edward AU - Hone E AD - Research Software Engineers Group, University of Exeter, Exeter, United Kingdom. FAU - McEachan, Rosemary R C AU - McEachan RRC AUID- ORCID: 0000-0003-1302-6675 AD - Bradford Institute for Health Research, Bradford Teaching Hospitals National Health Service Foundation Trust, Bradford, United Kingdom. FAU - Magnus, Maria C AU - Magnus MC AUID- ORCID: 0000-0002-0568-3774 AD - Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway. FAU - Havdahl, Alexandra AU - Havdahl A AD - Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway. AD - PsychGen Centre for Genetic Epidemiology and Mental Health, Division of Public Health and Prevention, Norwegian Institute of Public Health, Oslo, Norway. AD - Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway. AD - PROMENTA Research Centre, Department of Psychology, University of Oslo, Oslo, Norway. FAU - Relton, Caroline L AU - Relton CL AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - London School of Hygiene and Tropical Medicine, London, United Kingdom. LA - eng PT - Journal Article DEP - 20260723 PL - United States TA - PLoS Med JT - PLoS medicine JID - 101231360 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Child Health MH - Child MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Norway/epidemiology MH - Male MH - United Kingdom/epidemiology MH - Longitudinal Studies MH - Child, Preschool MH - Developmental Origins of Health and Disease MH - Smoking/adverse effects/epidemiology MH - Infant MH - Health Behavior MH - Infant, Newborn MH - *Parents MH - Alcohol Drinking/adverse effects/epidemiology MH - Risk Factors PMC - PMC13395330 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/23 CRDT- 2026/07/23 15:13 PHST- 2025/08/12 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 15:13 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - PMEDICINE-D-25-02845 [pii] AID - 10.1371/journal.pmed.1005153 [doi] PST - epublish SO - PLoS Med. 2026 Jul 23;23(7):e1005153. doi: 10.1371/journal.pmed.1005153. eCollection 2026 Jul. PMID- 42490250 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20261008 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Psychometric validation of the Italian State Urge to Be Physically Active Questionnaire in eating disorders: Psychopathology correlates and diagnostic differences. PG - e39-e50 LID - 10.1037/pas0001495 [doi] AB - Alongside excessive physical activity, individuals with eating disorders (EDs) frequently report a heightened urge to move and physical restlessness, which may contribute to both somatic and psychological burden. The State Urge to be Physically Active Questionnaire (SUPA-Q) specifically measures this acute, state-like dimension in ED patients, but a validated Italian version is not yet available. Two hundred thirty-three inpatients (93.6% female; M(age) = 31.7 +/- 14.3) formally diagnosed with EDs completed the SUPAQ-I alongside measures of compulsive exercise, exercise addiction, impulsivity, and ED psychopathology. Psychometric evaluation covered item performance, internal consistency, confirmatory factor analysis, convergent/divergent validity, sensitivity to change, and exploratory clinical cutoffs. Paired-samples t tests assessed score changes. SUPAQ-I scores demonstrated excellent reliability (alpha = .958, omega = 0.959) and good factorial validity. Scores significantly positively correlated with ED severity (drive for thinness, body dissatisfaction, overcontrol) and negatively with body mass index. Post hoc analyses revealed higher scores occurring in anorexia nervosa compared to binge-eating disorder, which decreased significantly over hospitalization, findings that are consistent with sensitivity to clinical change. High scores predominated in restrictive anorexia nervosa subtypes. Overall, findings support the psychometric adequacy of SUPAQ-I score interpretations for measuring acute movement urges in EDs. It appeared to capture an affect-driven and state-related dimension of movement urges related to, but not fully explained by, existing trait-based exercise measures and showed sensitive to clinical change. Further research is needed to refine cutoffs and examine the generalizability of these findings across populations and settings. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Boltri, Margherita AU - Boltri M AUID- ORCID: 0000-0002-6742-8541 AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Gabutti, Carolina AU - Gabutti C AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Brusa, Federico AU - Brusa F AUID- ORCID: 0000-0002-5353-7296 AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Cera, Giulia AU - Cera G AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Villa, Valentina AU - Villa V AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Laboratorio di Psicologia, Ospedale San Giuseppe. FAU - Bastoni, Ilaria AU - Bastoni I AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Laboratorio di Psicologia, Ospedale San Giuseppe. FAU - Ducale, Sara AU - Ducale S AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Laboratorio di Psicologia, Ospedale San Giuseppe. FAU - Manzo, Francesca AU - Manzo F AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Unita Operativa Complessa dei Disturbi dell'Alimentazione e della Nutrizione, Ospedale San Giuseppe. FAU - Scalia, Alberto AU - Scalia A AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Unita Operativa Complessa dei Disturbi dell'Alimentazione e della Nutrizione, Ospedale San Giuseppe. FAU - Apicella, Emanuela AU - Apicella E AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Savino, Sandra AU - Savino S AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Unita Operativa Complessa dei Disturbi dell'Alimentazione e della Nutrizione, Ospedale San Giuseppe. FAU - Castelnuovo, Gianluca AU - Castelnuovo G AD - Department of Psychology, Universita Cattolica del Sacro Cuore. FAU - Mendolicchio, Leonardo AU - Mendolicchio L AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. LA - eng SI - ClinicalTrials.gov/NCT06514456 GR - Italian Ministry of Health/ PT - Journal Article PT - Validation Study DEP - 20260723 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - Female MH - Psychometrics MH - Adult MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Italy MH - Surveys and Questionnaires/standards MH - Male MH - Young Adult MH - *Anorexia Nervosa/diagnosis/psychology MH - Adolescent MH - Middle Aged MH - *Exercise/psychology MH - Compulsive Exercise/psychology MH - Impulsive Behavior EDAT- 2026/07/23 18:35 MHDA- 2026/09/21 17:47 CRDT- 2026/07/23 12:43 PHST- 2026/09/21 17:47 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 12:43 [entrez] AID - 2028-02437-001 [pii] AID - 10.1037/pas0001495 [doi] PST - ppublish SO - Psychol Assess. 2026 Oct;38(10):e39-e50. doi: 10.1037/pas0001495. Epub 2026 Jul 23. PMID- 42489856 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1867-0687 (Electronic) IS - 1708-8569 (Print) VI - 22 IP - 6 DP - 2026 Jun TI - BMI-for-age Z-score trajectories in early childhood: a comparison of GMM and KML and associated antenatal and postnatal factors. PG - 664-677 LID - 10.1007/s12519-026-01057-y [doi] AB - BACKGROUND: Early-life growth trajectories, especially during the first two years, are important for future health. However, in the context of rapidly rising childhood obesity, it is essential to characterize BMI-for-age Z-score (BAZ) trajectories in early childhood, compare optimal modeling approaches, and identify associated risk factors. METHODS: This prospective birth cohort study enrolled participants in Jinan, Shandong from 2019 to 2022. World Health Organization (WHO)-standardized BAZ scores were calculated for children at eight timepoints (0-24 months). Sex-specific BAZ trajectories were derived using growth mixture modeling (GMM) and k-means for longitudinal data (KML). The possible risk of being overweight (BAZ > 1) at age three years was predicted using logistic regression with five folds cross-validation, comparing model performance via the area under the curve (AUC). Associations between trajectory classification and antenatal and postnatal factors were examined. RESULTS: A total of 4629 mother-infant dyads were enrolled in this study. The KML-derived four-class trajectory model demonstrated optimal predictive performance for possible risk of being overweight at age three years, achieving an AUC of 0.749 and significantly outperforming the GMM model (AUC = 0.571). Male sex [odds ratio (OR) = 1.314; 95% confidence interval (95% CI): 1.098, 1.572], high birth weight (OR = 4.739; 95% CI: 3.594, 6.250), multiparity (OR = 1.265; 95% CI: 1.003, 1.594), and gestational hypertension (OR = 2.581; 95% CI: 1.387, 4.801) were identified as risk factors for high growth trajectory. CONCLUSIONS: The KML model was identified as the more effective approach for delineating BAZ trajectories and predicting the risk of being overweight in our study population. Furthermore, male sex, high birth weight, multiparity, and gestational hypertension were identified as key antenatal and postnatal factors associated with higher growth trajectories. CI - (c) 2026. The Author(s). FAU - Zhang, Ting AU - Zhang T AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Li, Zi-Yun AU - Li ZY AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Zhang, Zhen-Yu AU - Zhang ZY AD - School of Clinical Medicine, Shandong Second Medical University, Weifang, China. FAU - Gao, Mai AU - Gao M AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Zhang, Li AU - Zhang L AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Liu, Hui-Juan AU - Liu HJ AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Wang, Hai-Jun AU - Wang HJ AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Li, Yan AU - Li Y AUID- ORCID: 0000-0003-2233-7061 AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. liyanxj@sina.com. LA - eng GR - 32500156/National Natural Science Foundation of China/ GR - Z20243204/Shandong Province Traditional Chinese Medicine Science and Technology Project/ PT - Comparative Study PT - Journal Article DEP - 20260723 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 SB - IM MH - Humans MH - Male MH - Female MH - Prospective Studies MH - *Body Mass Index MH - Child, Preschool MH - Risk Factors MH - Infant MH - Birth Cohort MH - *Pediatric Obesity/epidemiology MH - Infant, Newborn MH - China/epidemiology PMC - PMC13433460 OTO - NOTNLM OT - BAZ trajectory OT - Children OT - Growth mixture modeling OT - K-means for longitudinal data OT - Pediatric OT - Possible risk of being overweight COIS- Declarations. Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Ethical approval: Ethical approval was granted by Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University (No. 2025-040). EDAT- 2026/07/23 12:37 MHDA- 2026/08/04 06:37 PMCR- 2026/07/23 CRDT- 2026/07/23 11:08 PHST- 2026/01/06 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/02/24 00:00 [revised] PHST- 2026/08/04 06:37 [medline] PHST- 2026/07/23 12:37 [pubmed] PHST- 2026/07/23 11:08 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1007/s12519-026-01057-y [pii] AID - 1057 [pii] AID - 10.1007/s12519-026-01057-y [doi] PST - ppublish SO - World J Pediatr. 2026 Jun;22(6):664-677. doi: 10.1007/s12519-026-01057-y. Epub 2026 Jul 23. PMID- 42489731 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260923 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 23 TI - Psychological and lifestyle predictors of paediatric sleep disturbances: a cross-sectional study. LID - 10.1007/s00431-026-07254-1 [doi] LID - 603 AB - Sleep disturbances are frequent in childhood and have been associated with emotional vulnerability and modifiable lifestyle behaviours. The relative and combined contributions of child anxiety, parental anxiety, and unstructured daily routines to paediatric sleep disturbances remain incompletely characterized. We conducted a cross-sectional study of 306 otherwise healthy children aged 3-14 years. Parents completed validated questionnaires assessing sleep disturbances, child anxiety, parental anxiety, and daily lifestyle habits, including evening screen exposure. Multivariable linear regression, mediation, and cluster analyses were performed to identify correlates of sleep disturbances and distinct profiles. Clinically significant sleep disturbances were identified in 39.2% of participants. Higher child trait anxiety was consistently associated with greater sleep disturbance severity (all P < .001). Evening screen exposure was independently associated with higher sleep disturbance scores (P < .05). Parental trait anxiety not directly associated with sleep disturbances both directly and indirectly through child trait anxiety, which mediated approximately 30% of the association (P < .001). Cluster analysis identified three distinct profiles, including two groups with comparable sleep disturbance severity but contrasting characteristics: one marked by high emotional vulnerability and one by predominant lifestyle dysregulation. Conclusion: Sleep disturbances are strongly associated with trait anxiety and independently related to evening screen exposure, while parental anxiety appears to exert its effect both directly and, in part, indirectly through child anxiety. Similar sleep complaints may reflect different underlying emotional and lifestyle mechanisms. A multidimensional assessment integrating anxiety screening and evaluation of evening habits may improve early identification of at-risk children and support targeted preventive strategies within routine paediatric care. CI - (c) 2026. The Author(s). FAU - Suppiej, Agnese AU - Suppiej A AUID- ORCID: 0000-0001-5130-1450 AD - Paediatric Unit, University Hospital S. Anna, University of Ferrara, Ferrara, Italy. FAU - Sigolotto, Elia AU - Sigolotto E AUID- ORCID: 0009-0002-0673-856X AD - Paediatric Unit, University Hospital S. Anna, University of Ferrara, Ferrara, Italy. elia.sigolotto@edu.unife.it. FAU - Malaventura, Cristina AU - Malaventura C AUID- ORCID: 0000-0001-8517-4170 AD - Paediatric Unit, University Hospital S. Anna, University of Ferrara, Ferrara, Italy. LA - eng PT - Journal Article DEP - 20260723 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Female MH - *Sleep Wake Disorders/psychology/etiology/epidemiology MH - Male MH - Child, Preschool MH - *Life Style MH - Adolescent MH - *Anxiety/complications/psychology MH - Surveys and Questionnaires MH - *Parents/psychology MH - Risk Factors MH - Screen Time PMC - PMC13395844 OTO - NOTNLM OT - Child anxiety OT - Parental anxiety OT - Screen exposure OT - Sleep disturbances OT - Sleep hygiene COIS- Declarations. Ethics approval: This study adhered to the principles of the Declaration of Helsinki. Because it involved a completely anonymous, online form without collection of identifying information, approval by an Institutional Ethics Committee was not required. Consent to participate: Parents or legal guardians provided verbal consent to receive the form, and subsequent participation was entirely voluntary. No personal data were collected. Consent to publish: Not applicable. Use of AI-assisted technologies: During the preparation of this work, the authors used ChatGPT (OpenAI) solely to improve language, readability, and grammatical accuracy. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. Role of the funder: The funder had no role in the study design; data collection, analysis, or interpretation; manuscript preparation; or decision to submit the manuscript for publication. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/07/23 12:37 MHDA- 2026/07/23 12:38 PMCR- 2026/07/23 CRDT- 2026/07/23 11:04 PHST- 2026/02/07 00:00 [received] PHST- 2026/07/12 00:00 [accepted] PHST- 2026/05/04 00:00 [revised] PHST- 2026/07/23 12:38 [medline] PHST- 2026/07/23 12:37 [pubmed] PHST- 2026/07/23 11:04 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1007/s00431-026-07254-1 [pii] AID - 7254 [pii] AID - 10.1007/s00431-026-07254-1 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 23;185(8):603. doi: 10.1007/s00431-026-07254-1. PMID- 42489125 OWN - NLM STAT- Publisher LR - 20260723 IS - 1934-1563 (Electronic) IS - 1934-1482 (Linking) DP - 2026 Jul 23 TI - Lifestyle medicine innovations: Physical activity assessment in patient care and implementation of a digital health platform to support healthier movement. LID - 10.1002/pmrj.70185 [doi] AB - OBJECTIVE: To introduce the ExerciseRxTM digital health platform as a scalable approach to support personalized physical activity (PA) and home exercise as part of clinical care. DESIGN: Narrative review of Physical Activity Vital Sign (PAVS) integration within an academic healthcare system as well as description and ongoing research on a digital health platform to support physical activity as part of patient care. SETTING: Outpatient clinics within an academic medical center. PARTICIPANTS: Patients across multiple populations, including individuals with limb loss, multiple sclerosis, and primary care cohorts, as well as participants in pediatric rehabilitation, oncology, and rheumatology clinics. INTERVENTIONS: Integration of two standardized PAVS questions into the electronic health record and development of the ExerciseRx digital health platform incorporating smartphone and wearable step count tracking, personalized activity goals, and AI/ML home exercise sensing innovations. MAIN OUTCOME MEASURES: Self-reported PA levels, associations with demographic and clinical factors, healthcare utilization, and feasibility and usability of the digital health platform. RESULTS: PAVS assessment implementation demonstrated that a majority of patients across multiple clinic populations did not meet PA recommendations and highlighted demographic and clinical differences in activity levels. Higher self-reported PA was associated with lower healthcare utilization while controlling for confounding factors. Preliminary findings involving the ExerciseRx platform showed feasibility, high usability, and increased PA engagement, while enabling providers to monitor patient progress with actionable data. CONCLUSIONS: Routine assessment of PA through PAVS, combined with digital health tools such as the ExerciseRx platform, may help identify insufficiently active patients and support personalized, home-based exercise at scale. This approach aligns with priorities in lifestyle medicine and population health, with further research needed on clinical integration at scale. CI - (c) 2026 The Author(s). PM&R published by Wiley Periodicals LLC on behalf of American Academy of Physical Medicine and Rehabilitation. FAU - Lin, Cindy Y AU - Lin CY AD - Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA. AD - The Sports Institute at UW Medicine, Seattle, Washington, USA. FAU - Kehne, Theresa AU - Kehne T AUID- ORCID: 0009-0008-6453-2790 AD - Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA. AD - The Sports Institute at UW Medicine, Seattle, Washington, USA. LA - eng GR - Seattle Children's Research Institute/ GR - Bladder Cancer Advocacy Network/ GR - NCT06270641/National Multiple Sclerosis Society/ GR - Spondylitis Association of America/ GR - The Sports Institute at UW Medicine/ PT - Journal Article DEP - 20260723 PL - United States TA - PM R JT - PM & R : the journal of injury, function, and rehabilitation JID - 101491319 SB - IM EDAT- 2026/07/23 12:37 MHDA- 2026/07/23 12:37 CRDT- 2026/07/23 06:24 PHST- 2026/04/18 00:00 [revised] PHST- 2025/12/02 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/23 12:37 [medline] PHST- 2026/07/23 12:37 [pubmed] PHST- 2026/07/23 06:24 [entrez] AID - 10.1002/pmrj.70185 [doi] PST - aheadofprint SO - PM R. 2026 Jul 23. doi: 10.1002/pmrj.70185. PMID- 42488399 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260822 IS - 2673-3153 (Electronic) IS - 2673-3153 (Print) IS - 2673-3153 (Linking) VI - 8 DP - 2026 TI - Understanding practices of lactation and infant feeding together with women with HIV: the UPLIFT observational study protocol. PG - 1856899 LID - 10.3389/frph.2026.1856899 [doi] LID - 1856899 AB - INTRODUCTION: There is a limited understanding of infant feeding decisions, practices, and outcomes for women living with HIV (WLHIV) and their infants since U.S. guidelines were updated in 2023 to support breastfeeding for virally suppressed women on antiretroviral treatment. METHODS AND ANALYSIS: The Understanding Practices of Lactation and Infant Feeding Together with women with HIV (UPLIFT) study is a convergent mixed-methods, multisite, observational study designed to address key knowledge gaps. Twelve US sites will begin enrollment in early 2026 to accomplish three core activities (CA). In CA1, we explore infant feeding decision-making and experiences via in-depth interviews with pregnant/postpartum WLHIV (n = 50), their partners and other influential individuals (n = 25), and a diverse sample of healthcare professionals (n = 45). Site-level surveys assess infant feeding practices and estimate the prevalence of breastfeeding among WLHIV. In CA2, we establish an observational longitudinal cohort of 450 WLHIV-infant dyads to examine infant feeding practices and outcomes. WLHIV will be enrolled during pregnancy and early postpartum, with half intending to breastfeed, and will be followed for >/=48 weeks. Clinical and laboratory data will be collected. Comprehensive surveys collect data on demographics, social determinants of health, mental health, antiretroviral therapy adherence, and infant feeding intentions and experiences. We measure HIV RNA and DNA in breast milk to determine factors associated with detectable HIV. Finally, we estimate the costs and benefits associated with breastfeeding compared to replacement feeding. In CA3, we develop and pilot a voluntary registry of U.S. WLHIV who are breastfeeding and their infants (n = 50-200). Pilot registry testers (n = 30) will provide feedback on the usability, acceptability, appropriateness, and feasibility of the registry. DISCUSSION: The UPLIFT study will generate critical insights to inform patient-centered care, guide practice and policy, and empower WLHIV in the US to make informed infant feeding decisions. ETHICS AND DISSEMINATION: The UPLIFT study received approval from Advarra, the institutional review board of record for all UPLIFT sites. Results will be disseminated through conference presentations, peer-reviewed journals, and lay summaries. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT07293559, NCT07293559. CI - (c) 2026 Smith, Barr, Hampanda, Trumbull, Wu, McKinney, Buisson, Hoffmann, Brown, Hutchinson, Amico, Asiodu, McFarland, Lampe, Cholli, Varechtchouk, Esber, Kourtis and Abuogi. FAU - Smith, Christiana AU - Smith C AD - Department of Pediatrics, Section of Infectious Diseases and Epidemiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. FAU - Barr, Emily Anne AU - Barr EA AD - School of Nursing, University at Buffalo, Buffalo, NY, United States. FAU - Hampanda, Karen AU - Hampanda K AD - Department of Obstetrics and Gynecology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. FAU - Trumbull, Mark AU - Trumbull M AD - Frontier Science & Technology Research Foundation, Amherst, NY, United States. FAU - Wu, Hulin AU - Wu H AD - Department of Biostatistics & Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, United States. FAU - McKinney, Jennifer AU - McKinney J AD - Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX, United States. FAU - Buisson, Sarah AU - Buisson S AD - FHI 360, Durham, NC, United States. FAU - Hoffmann, Carly AU - Hoffmann C AD - Frontier Science & Technology Research Foundation, Amherst, NY, United States. FAU - Brown, Ciarra AU - Brown C AD - The Well Project, Brooklyn, NY, United States. FAU - Hutchinson, Angela B AU - Hutchinson AB AD - Division of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States. FAU - Amico, K Rivet AU - Amico KR AD - University of Michigan, School of Public Health, Ann Arbor, MI, United States. FAU - Asiodu, Ifeyinwa V AU - Asiodu IV AD - School of Nursing, University of California San Francisco, San Francisco, CA, United States. FAU - McFarland, Elizabeth J AU - McFarland EJ AD - Department of Pediatrics, Section of Infectious Diseases and Epidemiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. FAU - Lampe, Margaret A AU - Lampe MA AD - Division of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States. FAU - Cholli, Preetam A AU - Cholli PA AD - Division of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States. FAU - Varechtchouk, Olga AU - Varechtchouk O AD - Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States. FAU - Esber, Allahna AU - Esber A AD - Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States. FAU - Kourtis, Athena P AU - Kourtis AP AD - Division of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States. FAU - Abuogi, Lisa AU - Abuogi L AD - Department of Pediatrics, Section of Infectious Diseases and Epidemiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. LA - eng SI - ClinicalTrials.gov/NCT07293559 GR - HHSN275201800001C/HD/NICHD NIH HHS/United States GR - UM1 AI068632/AI/NIAID NIH HHS/United States GR - U01PS005288/ACL/ACL HHS/United States GR - U01 PS005288/PS/NCHHSTP CDC HHS/United States GR - UM1 AI068616/AI/NIAID NIH HHS/United States GR - UM1 AI106716/AI/NIAID NIH HHS/United States GR - HHSN275201800001I/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260708 PL - Switzerland TA - Front Reprod Health JT - Frontiers in reproductive health JID - 9918230899006676 PMC - PMC13388547 OTO - NOTNLM OT - breast milk OT - breastfeeding OT - infant exposure to HIV OT - infant feeding OT - lactation OT - perinatal HIV transmission OT - pregnancy OT - woman living with HIV COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:40 PMCR- 2026/07/08 CRDT- 2026/07/23 04:51 PHST- 2026/04/15 00:00 [received] PHST- 2026/06/03 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/23 06:40 [medline] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 04:51 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.3389/frph.2026.1856899 [doi] PST - epublish SO - Front Reprod Health. 2026 Jul 8;8:1856899. doi: 10.3389/frph.2026.1856899. eCollection 2026. PMID- 42488232 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Telemedicine follow-up and nutritional outcomes in children with neurological impairment: a longitudinal study. PG - 1868448 LID - 10.3389/fped.2026.1868448 [doi] LID - 1868448 AB - BACKGROUND: Children with neurological impairment are at high risk of malnutrition and require regular nutritional monitoring. Telemedicine has been increasingly used to support follow-up visits, but its impact on nutritional outcomes remains unclear. METHODS: We conducted a longitudinal observational study including 152 children with neurological impairment. Patients received either standard in-person follow-up or a combination of in-person and telemedicine visits. Nutritional status was assessed using body mass index (BMI) z-score at baseline and follow-up. Nutritional outcome was classified as improved, stable, or worsened based on changes in BMI z-score. The aim of this study was to evaluate the association between telemedicine follow-up and nutritional outcomes and to identify clinical factors associated with nutritional worsening. Multivariable logistic regression was performed to identify predictors of nutritional deterioration. RESULTS: At baseline, children in the telemedicine group were younger and had a higher prevalence of percutaneous endoscopic gastrostomy (PEG) (p = 0.013), while no differences were observed in gross motor function classification system (GMFCS) severity or baseline nutritional status. No significant differences were observed between groups in BMI z-score at follow-up (p = 0.877), change in BMI z-score (p = 0.458), nutritional status at follow-up (p = 0.356), or nutritional outcome (p = 0.329). In multivariable analysis, baseline BMI z-score was associated with nutritional worsening (OR 1.23, 95% CI 1.04-1.50; p = 0.013), whereas telemedicine follow-up (p = 0.166), age (p = 0.767), PEG (p = 0.869), GMFCS severity (p = 0.704), and follow-up duration (p = 0.352) were not associated with worsening. CONCLUSION: Baseline BMI z-score was the only variable independently associated with nutritional worsening during follow-up. No statistically significant differences in nutritional outcomes were observed between telemedicine and standard care groups; however, differences in baseline characteristics limit direct comparability. Telemedicine may represent a feasible and complementary approach to support follow-up in nutritionally vulnerable pediatric patients. CI - (c) 2026 Eletti, Perico, Visioli, Montanari, Tagi, Vizzuso, Calcaterra, Borsani and Zuccotti. FAU - Eletti, Francesca AU - Eletti F AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Perico, Veronica AU - Perico V AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Visioli, Alessandro AU - Visioli A AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Montanari, Chiara AU - Montanari C AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Tagi, Veronica Maria AU - Tagi VM AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Vizzuso, Sara AU - Vizzuso S AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Calcaterra, Valeria AU - Calcaterra V AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy. FAU - Borsani, Barbara AU - Borsani B AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. LA - eng PT - Journal Article DEP - 20260708 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13388881 OTO - NOTNLM OT - GMFCS OT - gastrostomy OT - malnutrition OT - neurological impairment OT - nutritional status OT - pediatrics OT - telemedicine COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:40 PMCR- 2026/07/08 CRDT- 2026/07/23 04:49 PHST- 2026/04/29 00:00 [received] PHST- 2026/06/19 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/23 06:40 [medline] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 04:49 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1868448 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 8;14:1868448. doi: 10.3389/fped.2026.1868448. eCollection 2026. PMID- 42487800 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Enhancing organizational health literacy through pediatric clinical training: Mini-CEX-based formative assessment in case-based learning for pediatric pneumonia-a perspective. PG - 1880936 LID - 10.3389/fpubh.2026.1880936 [doi] LID - 1880936 AB - Organizational health literacy (OHL) remains a critical yet underexplored dimension of health equity, particularly at the interface between clinical training and patient care. This article proposes a conceptual reframing of the Mini-Clinical Evaluation Exercise (Mini-CEX) as an OHL-oriented formative assessment tool within case-based learning for pediatric pneumonia. The OHL-Mini-CEX model integrates three assessment domains-teach-back evaluation, de-jargonization capacity, and empowering guidance-to systematically evaluate residents' communicative competence in addressing health literacy barriers. We delineate the mechanisms through which this instrument operates: embedding equity-conflict scenarios into teaching cases, generating bidirectional formative feedback for both clinicians and organizations, and constructing a closed loop from micro-level training to macro-level health equity outcomes. Implementation challenges, including faculty preparedness gaps and psychometric rigor, are examined alongside integrated strategies drawing on public health collaboration. This perspective advances a theoretically grounded and practically actionable pathway for transforming clinical education into an institutional driver of health equity. CI - Copyright (c) 2026 Ge, Li, Mu and Wan. FAU - Ge, Sheng-Nan AU - Ge SN AD - Department of Pediatric, Luohu District Hospital of Traditional Chinese Medicine, Shenzhen, China. FAU - Li, Bing AU - Li B AD - Department of Pediatric, Luohu District Hospital of Traditional Chinese Medicine, Shenzhen, China. FAU - Mu, Bing-Yan AU - Mu BY AD - Department of Pediatric, Luohu District Hospital of Traditional Chinese Medicine, Shenzhen, China. FAU - Wan, Li-Sheng AU - Wan LS AD - Department of Chinese Medicine, Shenzhen Children's Hospital, Shenzhen, China. LA - eng PT - Journal Article DEP - 20260708 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Health Literacy MH - *Pneumonia/therapy MH - *Pediatrics/education MH - *Problem-Based Learning MH - *Educational Measurement/methods MH - Child PMC - PMC13388563 OTO - NOTNLM OT - Mini-clinical evaluation exercise OT - case-based learning OT - clinical training OT - formative assessment OT - health equity OT - organizational health literacy OT - pediatric pneumonia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:40 PMCR- 2026/07/08 CRDT- 2026/07/23 04:45 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/04 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/23 06:40 [medline] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 04:45 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1880936 [doi] PST - epublish SO - Front Public Health. 2026 Jul 8;14:1880936. doi: 10.3389/fpubh.2026.1880936. eCollection 2026. PMID- 42487795 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260923 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - The effect of physical exercise on social appearance anxiety among college students: the serial mediating role of social media addiction and self-objectification. PG - 1866510 LID - 10.3389/fpubh.2026.1866510 [doi] LID - 1866510 AB - BACKGROUND: Social appearance anxiety (SAA) has become a prominent mental health issue among Chinese college students, and it is particularly exacerbated in the mobile Internet era, marked by the pervasive use of social media. As an active health-promoting behavior, physical exercise is widely recognized as being able to effectively alleviate individuals' mental health problems, yet its underlying psychological mechanisms remain inadequately explored. Therefore, this study is based on social comparison theory, this study aims to investigate the relationship between physical exercise and SAA among Chinese college students, and to examine the serial mediating role of social media addiction and self-objectification in this association. METHODS: A convenience sampling method was adopted to administer a questionnaire survey among college students from universities in central China, yielding 415 valid responses. The measurement instruments included the Physical Activity Rating Scale-3 (PARS-3), Social Appearance Anxiety Scale (SAA), Bergen Facebook Addiction Scale (BFAS), and Self-Objectification Beliefs and Behaviors Scale (SOBB). Data analyses were performed using SPSS 27.0 and PROCESS 4.2 macro, and the Bootstrap method was adopted to test the serial mediating effects with 5,000 resamples. RESULTS: Correlation analyses revealed significant bivariate correlations between all variables. Serial mediation analysis indicated that the total effect of physical exercise on SAA was -0.498, and the direct effect was -0.313, accounting for 62.85%. All three indirect paths were significant: the independent mediating effect of social media addiction was -0.080, accounting for 16.06%; the independent mediating effect of self-objectification was -0.083, making up 16.67%; and the serial mediating effect of social media addiction and self-objectification was -0.022, accounting for 4.42% of the total effect. CONCLUSION: Physical exercise helps reduce college students' SAA directly, and offers indirect benefits by suppressing social media addiction and alleviating self-objectification through independent and serial mediating pathways. These findings enrich the understanding of the psychological mechanisms through which physical exercise influences SAA, provide empirical evidence to advance the dynamic development of social comparison theory, and offer practical and targeted approaches to promote mental health in higher education contexts. CI - Copyright (c) 2026 Tang, Zhang and Yu. FAU - Tang, Ningxiao AU - Tang N AD - School of Physical Education, Hunan University of Science and Technology, Xiangtan, China. FAU - Zhang, Kangyuan AU - Zhang K AD - School of Physical Education, Hunan University of Science and Technology, Xiangtan, China. FAU - Yu, Le AU - Yu L AD - School of Physical Education, Hunan University of Science and Technology, Xiangtan, China. LA - eng PT - Journal Article DEP - 20260708 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/psychology/statistics & numerical data MH - *Exercise/psychology MH - *Social Media MH - Universities MH - Female MH - Young Adult MH - Male MH - China MH - *Anxiety/psychology MH - *Behavior, Addictive/psychology MH - Surveys and Questionnaires MH - *Self Concept MH - Adolescent MH - Digital Media PMC - PMC13390606 OTO - NOTNLM OT - physical exercise OT - self-objectification OT - serial mediating effect OT - social appearance anxiety OT - social media addiction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:40 PMCR- 2026/07/08 CRDT- 2026/07/23 04:45 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/19 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 06:40 [medline] PHST- 2026/07/23 04:45 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1866510 [doi] PST - epublish SO - Front Public Health. 2026 Jul 8;14:1866510. doi: 10.3389/fpubh.2026.1866510. eCollection 2026. PMID- 42487370 OWN - NLM STAT- Publisher LR - 20260723 IS - 0975-5764 (Electronic) IS - 0975-5764 (Linking) DP - 2026 Jul 23 TI - CTLA-4 Gene Polymorphism in Pediatric Type 1 Diabetes Mellitus: A Case-Control Study. LID - 10.4103/aam.aam_368_26 [doi] AB - OBJECTIVE: To analyze the relationship between CTLA-4 (+49A/G) polymorphism and pediatric type 1 diabetes mellitus (T1DM). MATERIALS AND METHODS: The observational case-control study was done for 18 months in 44 children (1-16 years of age), 22 of whom had T1DM and 22 controls, were included. CTLA-4 (+49A/G) gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism and validated by Sanger sequencing. Various clinical, anthropometric, and biochemistry variables were documented. RESULTS: The cases and controls were similar in terms of age, gender distribution, family history of diabetes, and consanguinity. The average hemoglobin A1c values were higher in case groups compared to controls (12.41% +/-3.09% vs. 4.21 +/- 0.5%; P < 0.001). The CTLA4 (+49A/G) gene showed higher frequencies of the G/G genotype in cases compared to controls (54.55% vs. 22.73%; P = 0.030), whereas A/A was found to be higher in controls (P = 0.014). The frequency of the G allele in cases (0.66) was higher than in controls (0.32). The G/G genotype showed higher prevalence in the case group at a younger age, and siblings of offspring showed clustering of the G/G genotype. CONCLUSION: In particular, the G/G genotype of the CTLA-4 + 49A/G polymorphism was found to be significantly associated with T1DM in children and to influence the age of onset. CI - Copyright (c) 2026 Annals of African Medicine. FAU - Aniketh, Thammineni AU - Aniketh T AD - Department of Pediatrics, Shri B. M. Patil Medical College and Hospital and Research Center, BLDE (Deemed to be University), Vijayapura, Karnataka, India. FAU - Gobbur, Raghavendra AU - Gobbur R AD - Department of Pediatrics, Shri B. M. Patil Medical College and Hospital and Research Center, BLDE (Deemed to be University), Vijayapura, Karnataka, India. FAU - Kadakol, Gurushantappa S AU - Kadakol GS AD - Department of Anatomy, Genetics Laboratory, School of Applied Sciences and Technology, BLDE (Deemed to be University), Vijayapura, Karnataka, India. LA - fre LA - eng PT - Journal Article DEP - 20260723 PL - India TA - Ann Afr Med JT - Annals of African medicine JID - 101231417 SB - IM OTO - NOTNLM OT - +49A/G polymorphism OT - Polymorphisme +49A/G OT - Sanger sequencing OT - diabete sucre de type 1 OT - familial risk OT - genetic susceptibility OT - pediatric OT - pediatrique OT - risque familial OT - susceptibilite genetique OT - sequencage de Sanger OT - type 1 diabetes mellitus EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:39 CRDT- 2026/07/23 02:02 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/07/23 06:39 [medline] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 02:02 [entrez] AID - 01244624-990000000-01068 [pii] AID - 10.4103/aam.aam_368_26 [doi] PST - aheadofprint SO - Ann Afr Med. 2026 Jul 23. doi: 10.4103/aam.aam_368_26. PMID- 42487232 OWN - NLM STAT- Publisher LR - 20260723 IS - 2168-6602 (Electronic) IS - 0890-1171 (Linking) DP - 2026 Jul 22 TI - Promoting Active Schools in the United States: A Feasibility Study Applying the Interactive Systems Framework. PG - 8901171261471044 LID - 10.1177/08901171261471044 [doi] AB - PurposeThis feasibility study explored the application of the Interactive Systems Framework for Dissemination and Implementation (ISF) to promote physical activity (PA) in elementary schools, leveraging resources from Active Schools.ApproachA convergent parallel mixed-methods design was used to examine implementation efforts and student PA outcomes.SettingData were collected from eight elementary schools across the United States.ParticipantsThe study included eight Active Schools Champions (physical education teachers) and 371 students.MethodsChampions completed the School Wellness Readiness Assessment (SWRA) and the Comprehensive School Physical Activity Program (CSPAP) Policies and Practices Questionnaire. A survey and interview based on the Consolidated Framework for Implementation Research (CFIR) also captured barriers and facilitators. Concurrently, student PA patterns were assessed using the Youth Activity Profile (YAP).ResultsSchools demonstrated moderate readiness (mean SWRA = 3.7) and implemented an average of 64% of CSPAP best practices. Student PA exceeded national recommendations, averaging 70 minutes per day, with most of this activity occurring during the school day. Organizational barriers, such as a lack of administrative support, were identified.ConclusionThe findings document the successful implementation of CSPAP and provide insights into organizational barriers and facilitators. This study highlights the value of accessible, evidence-based resources and needs assessment tools, while also revealing challenges related to time-intensive professional development and disparities in readiness across different school locales. The results will inform future interventions and resources to promote more equitable PA opportunities. FAU - Ha, Taemin AU - Ha T AUID- ORCID: 0000-0003-2830-9029 AD - Department of Family, Nutrition, and Exercise Sciences, City University of New York-Queens College, New York City, NY, USA. FAU - Stoepker, Peter AU - Stoepker P AUID- ORCID: 0000-0002-1925-5690 AD - School of Health Sciences, Kansas State University, Manhattan, KS, USA. RINGGOLD: 5308 FAU - Welk, Gregory AU - Welk G AD - Department of Kinesiology, Iowa State University, Ames, IA, USA. FAU - Dauenhauer, Brian AU - Dauenhauer B AUID- ORCID: 0000-0001-6766-1178 AD - Department of Kinesiology, Nutrition, and Dietetics, University of Northern Colorado, Greeley, CO, USA. RINGGOLD: 3604 LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM OTO - NOTNLM OT - physical activity OT - public health OT - school health OT - school system OT - whole-of-school EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:39 CRDT- 2026/07/23 00:42 PHST- 2026/07/23 06:39 [medline] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 00:42 [entrez] AID - 10.1177/08901171261471044 [doi] PST - aheadofprint SO - Am J Health Promot. 2026 Jul 22:8901171261471044. doi: 10.1177/08901171261471044. PMID- 42487004 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261015 IS - 1437-1596 (Electronic) IS - 0937-9827 (Print) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - The influence of adjacent anatomical context in tooth staging: observational study of non-cropped vs. cropped radiographs for dental age estimation. PG - 4483-4493 LID - 10.1007/s00414-026-03929-4 [doi] AB - Dental age estimation (DAE) is applicable to forensic/legal and clinical contexts, with the Demirjian staging system being among the most common techniques. However, inter- and intra-observer variability can affect DAE reliability, particularly when evaluating panoramic radiographs influenced by magnification, distortion, and anatomical superimposition. In the staging process, consciously or unconsciously, experts analyze dental development within the available peripheral anatomic features of the tooth and its peripheral region. This study investigated whether isolating teeth as regions of interest (cropped images) influences the reproducibility of Demirjian's stage allocation. An observational cross-sectional study was conducted using 301 panoramic radiographs from subjects aged 7-14 years. Three experienced forensic odontologists independently staged all seven left mandibular teeth (#31-#37) and, when present, also the left mandibular third molar (#38) using the Demirjian's staging system. Each tooth was evaluated twice, two weeks apart, in both full panoramic radiograph and cropped formats. Inter- and intra-observer agreement was assessed using kappa statistics. Intra-observer agreement was above 0.81. Cropped images resulted in only marginal changes, with a slight decrease in stage reproducibility (Delta - 0.017 and - 0.023). Inter-observer agreement was nearly identical between non-cropped (AC2 = 0.985) and cropped images (AC2 = 0.986). A slightly lower proportion of cropped images was assessable by all observers (90.7% vs. 91.7%). Isolating teeth as regions of interest did not meaningfully reduce reproducibility and only small intra-observer decreases were observed and concentrated in the anterior teeth. These findings indicate that, among experienced observers, cropping does not degrade the reliability of Demirjian stage allocation. Future DAE staging systems should consider being more descriptive, including not only tooth-related developmental details, but surrounding information, such as the distance between the analyzed tooth and the occlusal plane and its relationship with adjacent developed teeth. CI - (c) 2026. The Author(s). FAU - Angelakopoulos, Nikolaos AU - Angelakopoulos N AUID- ORCID: 0000-0001-8511-4645 AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland. AD - Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. FAU - Boedi, Rizky Merdietio AU - Boedi RM AUID- ORCID: 0000-0002-5045-6773 AD - Department of Dentistry, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia. AD - Department of Forensic Medicine, Sechenov First Moscow State Medical University, Moscow, Russia. FAU - De Luca, Stefano AU - De Luca S AUID- ORCID: 0000-0002-1725-0853 AD - Area of Physical Anthropology, Department of Organisms and Systems Biology, Faculty of Biology, University of Oviedo, Oviedo, Spain. lucastefano@uniovi.es. FAU - Vazquez, Israel Soriano AU - Vazquez IS AUID- ORCID: 0009-0009-2603-5950 AD - Forensic Odontologist, independent researcher, Mexico City, Mexico. FAU - Franco, Ademir AU - Franco A AUID- ORCID: 0000-0002-1417-2781 AD - Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260723 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Age Determination by Teeth/methods MH - Cross-Sectional Studies MH - Mandible MH - Observer Variation MH - *Radiography, Panoramic MH - Reproducibility of Results MH - *Tooth/diagnostic imaging/growth & development PMC - PMC13658412 OTO - NOTNLM OT - Age estimation OT - Demirjian system OT - Dental age OT - Forensic dentistry OT - Image cropping OT - Inter-observer agreement OT - Regions of interest OT - Reliability COIS- Declarations. Ethical approval: This study received ethical approval from the Health Research Ethics Committee of the Faculty of Medicine, Universitas Diponegoro (Approval No. 212/EC/KEPK/FK-UNDIP/VIII/2025) The study used fully anonymized, retrospectively collected data from an existing dataset with no direct involvement of human participants. Compliance with ethical standards: The study was carried out following the ethical standards of the Declaration of Helsinki (Finland). Research involving human participants and/or animals: Not applicable. Informed consent: Not applicable. Clinical trial number: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/23 05:36 MHDA- 2026/10/12 17:30 PMCR- 2026/07/23 CRDT- 2026/07/22 23:27 PHST- 2026/06/03 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/23 05:36 [pubmed] PHST- 2026/07/22 23:27 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1007/s00414-026-03929-4 [pii] AID - 3929 [pii] AID - 10.1007/s00414-026-03929-4 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):4483-4493. doi: 10.1007/s00414-026-03929-4. Epub 2026 Jul 23. PMID- 42486265 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260908 IS - 1532-0480 (Electronic) IS - 1532-0464 (Linking) VI - 181 DP - 2026 Sep TI - Predicting healthy weight status from physical activity and dietary intake: A time-aware data mining pipeline. PG - 105083 LID - S1532-0464(26)00107-3 [pii] LID - 10.1016/j.jbi.2026.105083 [doi] AB - OBJECTIVE: To develop and evaluate a time-aware data mining pipeline that integrates accelerometry-based Physical Activity (PA), static dietary intake, and sociodemographic factors to predict Healthy Weight Status (HWS), and identify features with predictive importance for HWS. METHODS: We propose TimePAD, Time-Based Physical Activity and Dietary Intake data mining, a three-stage prediction pipeline that integrates time-based PA representations, static dietary intake, and sociodemographic variables to predict HWS categories. Stage 1 derives intensity-specific hourly PA sequences and learns time-of-day PA embeddings using a Transformer encoder trained with masked Self-Supervised Learning (SSL) reconstruction. Stage 2 combines the learnt PA embeddings with static dietary variables and participant characteristics derived from the Food Frequency Questionnaire (FFQ). Stage 3 trains prediction models and ranks predictors by their predictive importance for HWS. TimePAD was evaluated on a real-world dataset of 206 adolescents (10-16 years) with 7-day continuous wrist-worn accelerometer data, FFQ records, and sociodemographic attributes, using 10-fold cross-validation and comparison to an ARIMA-based feature engineering baseline. RESULTS: TimePAD achieves an accuracy of 82.90% and an F1-score of 67.92% for HWS prediction, outperforming the best baseline (ARIMA-based PA features + diet, 77.51% accuracy). Across experiments, time-of-day light PA (LPA) features were consistently ranked as important predictors. Other key features include time-of-day Moderate-to-Vigorous Activity (MVPA) and Sedentary (SED) levels, Tanner stage, total weekly sleep time, age (in months), weekly fruit intake, weekly vegetable and legume intake, and intake of sugar-sweetened beverages. DISCUSSION: TimePAD contributes a pipeline for learning from the time-of-day structure in wearable PA time series and integrating it with static dietary and contextual data for prediction and feature analysis. The findings suggest that LPA is likely to have a significant association with HWS, calling for further attention and investigation to better understand the role of LPA in overall health outcomes. This illustrates the potential benefits of TimePAD in modelling PA with dietary intake context in shaping healthy behaviours. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Yu, Xiaotong AU - Yu X AD - School of Computer Science, The University of Sydney, Sydney, NSW 2008, Australia. FAU - Kim, Joshua Y AU - Kim JY AD - School of Computer Science, The University of Sydney, Sydney, NSW 2008, Australia. FAU - Wattelez, Guillaume AU - Wattelez G AD - Institute for Societies, Languages and Education, University of New Caledonia, Noumea, 98800, New Caledonia. FAU - Galy, Olivier AU - Galy O AD - Institute for Societies, Languages and Education, University of New Caledonia, Noumea, 98800, New Caledonia. FAU - Caillaud, Corinne AU - Caillaud C AD - Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2008, Australia; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2008, Australia. FAU - Yacef, Kalina AU - Yacef K AD - School of Computer Science, The University of Sydney, Sydney, NSW 2008, Australia. Electronic address: kalina.yacef@sydney.edu.au. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - J Biomed Inform JT - Journal of biomedical informatics JID - 100970413 SB - IM MH - Humans MH - *Data Mining/methods MH - *Exercise MH - Adolescent MH - Child MH - Female MH - *Body Weight MH - Male MH - Accelerometry MH - *Diet MH - Prediction Algorithms MH - Predictive Learning Models OTO - NOTNLM OT - Adolescent healthy weight status OT - Multimodal data integration OT - Physical activity OT - Time-series feature learning OT - Wearable sensor data COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/23 05:36 MHDA- 2026/08/18 23:36 CRDT- 2026/07/22 19:11 PHST- 2026/01/26 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/08/18 23:36 [medline] PHST- 2026/07/23 05:36 [pubmed] PHST- 2026/07/22 19:11 [entrez] AID - S1532-0464(26)00107-3 [pii] AID - 10.1016/j.jbi.2026.105083 [doi] PST - ppublish SO - J Biomed Inform. 2026 Sep;181:105083. doi: 10.1016/j.jbi.2026.105083. Epub 2026 Jul 22. PMID- 42485433 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1946-6242 (Electronic) IS - 1946-6234 (Linking) VI - 18 IP - 859 DP - 2026 Jul 22 TI - At-home wearable measurements provide detailed growth charts of infant early gross motor development. PG - eadz7035 LID - 10.1126/scitranslmed.adz7035 [doi] AB - Early gross motor performance is a key component of neurodevelopmental assessments, and longitudinal follow-ups in personalized health care need better objective methods for measuring it. We studied how the detailed characteristics of infants' gross motor development could be modeled with age-normative growth charts. We performed serial at-home measurements (total of 580 measurements, 1227 hours of free playtime) from a cohort of 92 typically developing infants at 4 to 19 months of age, using wearable suits with four movement sensors. A previously developed and validated, fully automated analysis pipeline detected postures and movements at a second-by-second resolution, to be used for deriving 220 detailed motor metrics of postures, movements, transition dynamics, locomotion types, and activity counts. The results showed that early gross motor development is sufficiently stable for constructing robust growth charts, most prominently for modeling evolving postures and their dynamics, and a wide range of motor metrics have sufficient temporal stability to provide reliable individual-level tracking. External validation in a clinical cohort with 39 infants, including participants with both typical and abnormal neurodevelopment, showed that the growth charts were highly generalizable (91% of the studied motor metrics were statistically comparable to those of the normative cohort), and 55% of the motor metrics showed statistical differentiation of abnormal neurodevelopment. These findings indicate that measurements of at-home wearables can provide assessments to meet a wide range of needs in health care and developmental science. FAU - Airaksinen, Manu AU - Airaksinen M AUID- ORCID: 0000-0002-8031-2260 AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. AD - Department of Physiology, University of Helsinki, 00290 Helsinki, Finland. AD - Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Systemic Ethology and Developmental Science - SEE, University Hospital Heidelberg, Heidelberg University, 69115 Heidelberg, Germany. FAU - Taylor, Elisa AU - Taylor E AUID- ORCID: 0009-0000-3302-5130 AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. FAU - Palsa, Taru AU - Palsa T AUID- ORCID: 0009-0007-6523-988X AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. FAU - de Sena, Sofie AU - de Sena S AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. FAU - Haataja, Leena AU - Haataja L AUID- ORCID: 0000-0002-8057-6194 AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. AD - Department of Pediatric Neurology, Children's Hospital, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. FAU - Vanhatalo, Sampsa AU - Vanhatalo S AUID- ORCID: 0000-0002-9771-7061 AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. AD - Department of Physiology, University of Helsinki, 00290 Helsinki, Finland. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - Sci Transl Med JT - Science translational medicine JID - 101505086 SB - IM MH - Humans MH - Infant MH - *Wearable Electronic Devices MH - *Child Development/physiology MH - Female MH - *Growth Charts MH - Male MH - Posture/physiology MH - Movement/physiology EDAT- 2026/07/22 18:37 MHDA- 2026/07/22 18:38 CRDT- 2026/07/22 14:02 PHST- 2026/07/22 18:38 [medline] PHST- 2026/07/22 18:37 [pubmed] PHST- 2026/07/22 14:02 [entrez] AID - 10.1126/scitranslmed.adz7035 [doi] PST - ppublish SO - Sci Transl Med. 2026 Jul 22;18(859):eadz7035. doi: 10.1126/scitranslmed.adz7035. Epub 2026 Jul 22. PMID- 42485298 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - The relationship between fat talk and body image in Chinese female nursing students: The mediating role of self-acceptance. PG - e0351756 LID - 10.1371/journal.pone.0351756 [doi] LID - e0351756 AB - OBJECTIVE: This study examined whether self-acceptance mediates the relationship between fat talk and body image among Chinese female nursing students, a group under high appearance pressure. METHODS: A cross-sectional survey was conducted among 1,280 female nursing students from five medical universities in Henan Province, China, Participants were recruited from randomly selected classes, and questionnaires were distributed in person via QR codes.. Participants completed validated scales measuring fat talk (Fat Talk Scale), self-acceptance (Self-Acceptance Questionnaire), and body image (Body Image States Scale). Data were analyzed using correlation and mediation analysis (PROCESS macro, Model 4) with bootstrapping. RESULTS: Fat talk was positively correlated with both self-acceptance (r = 0.543, p < 0.001) and body image (r = 0.344, p < 0.001). Self-acceptance was also positively correlated with body image (r = 0.457, p < 0.001). After controlling for "relationship status, grade, only child status, and BMI,Mediation analysis revealed a significant indirect effect of fat talk on body image through self-acceptance (effect = 0.174, 95% CI [0.132, 0.222]), accounting for 57.80% of the total effect (total effect = 0.301). The direct effect remained significant (effect = 0.127, 95% CI [0.032, 0.222]).The standardized indirect effect (beta = 0.080) indicates a small-to-moderate effect size. CONCLUSION: Among Chinese female nursing students, engaging in fat talk conversations is associated with a more positive body image. Self-acceptance accounting for 57.80% of the total effect, though the standardized indirect effect (beta = 0.080) suggests a small-to-moderate effect size. This finding highlights the importance of cultural and contextual factors in shaping body discourse and suggests that fostering supportive communication environments and self-acceptance could be beneficial in this population. CI - Copyright: (c) 2026 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Wang, Fengxia AU - Wang F AUID- ORCID: 0009-0009-6173-1628 AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Wang, Yuxiao AU - Wang Y AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Wang, Yufan AU - Wang Y AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Yang, Qihao AU - Yang Q AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Qiu, Ju AU - Qiu J AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Li, Jinyan AU - Li J AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Liu, Meng AU - Liu M AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Wang, Xiaowei AU - Wang X AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Li, Li AU - Li L AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Xia, Xichao AU - Xia X AUID- ORCID: 0000-0001-7836-8110 AD - Pingdingshan University, Pingdingshan, Henan, China. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - Chinese people SB - IM MH - Humans MH - Female MH - *Body Image/psychology MH - *Students, Nursing/psychology MH - China MH - *Self Concept MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Body Satisfaction MH - East Asian People PMC - PMC13390842 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/22 18:37 MHDA- 2026/07/22 18:38 PMCR- 2026/07/22 CRDT- 2026/07/22 13:33 PHST- 2026/01/07 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/22 18:38 [medline] PHST- 2026/07/22 18:37 [pubmed] PHST- 2026/07/22 13:33 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - PONE-D-25-68898 [pii] AID - 10.1371/journal.pone.0351756 [doi] PST - epublish SO - PLoS One. 2026 Jul 22;21(7):e0351756. doi: 10.1371/journal.pone.0351756. eCollection 2026. PMID- 42485103 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261019 IS - 1555-905X (Electronic) IS - 1555-9041 (Print) IS - 1555-9041 (Linking) VI - 21 IP - 10 DP - 2026 Oct 1 TI - Early and Stage-Dependent Cardiopulmonary Fitness Impairment in Pediatric CKD. PG - 1719-1732 LID - 10.2215/CJN.0000001113 [doi] AB - KEY POINTS: Children with CKD exhibit markedly lower cardiopulmonary fitness with an absolute maximal oxygen uptake deficit of 10 ml/kg per minute compared with reference values. More than half of the patients show impaired fitness as early as CKD stage 3, highlighting early functional vulnerability. Maximal oxygen uptake is independently associated with modifiable parameters commonly targeted by rehabilitation, supporting tailored intervention strategies. BACKGROUND: Children with CKD are at high cardiovascular risk, yet cardiopulmonary fitness is rarely assessed in routine care. Maximal oxygen uptake (VO 2 max) is a powerful prognostic marker, and Z -score-based evaluations may improve early risk stratification. METHODS: In this prospective multicenter study, children aged 6-17 years with CKD stages 2-5 (Kidney Disease Improving Global Outcome) underwent standardized cardiopulmonary exercise testing (CPET). VO 2 max was expressed as Z -scores using contemporary pediatric reference values. Impaired fitness was defined as VO 2 max Z -score <-1.64. Multivariable linear regression was used to identify independent determinants of VO 2 max. RESULTS: Among 88 enrolled patients (mean age 12+/-4 years, 67% male), 77 completed a valid CPET. Mean VO 2 max Z -score was -1.8+/-2.1, corresponding to 33.5+/-9.2 ml/kg per minute, that is, an absolute lowering of approximately 10 ml/kg per minute compared with age-matched and sex-matched reference values. Overall, 57% had impaired fitness. VO 2 max was progressively lower across higher CKD stages ( P < 0.001 ). In multivariable analysis, higher VO 2 max was independently associated with higher hemoglobin concentration, better pulmonary function (forced expiratory volume in 1 s), better ventilatory efficiency (VE/VCO 2 slope), and higher ventilatory anaerobic threshold, explaining 77% of VO 2 max variability. CONCLUSIONS: Cardiopulmonary fitness is markedly lower in children with CKD, with a clear stage-dependent decline that is already evident at early disease stages. The magnitude of VO 2 max impairment is substantial and related to potentially modifiable clinical and functional factors, supporting early CPET-based screening and the development of targeted, multidisciplinary rehabilitation in pediatric CKD. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Clinicaltrials.gov identifier NCT04897672 and Montpellier University Hospital Institutional Review Board (IRB 202100852). CI - Copyright (c) 2026 by the American Society of Nephrology. FAU - Werner, Oscar AU - Werner O AUID- ORCID: 0000-0002-3741-0498 AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. AD - Department of Pediatric Cardiology and Pediatric Cardiac Surgery, FHU PRECICARE, Nantes University, CHU Nantes, Nantes, France. AD - IHU Liryc, Electrophysiology and Heart Modelling Institute, INSERM U1045, University of Bordeaux, Bordeaux, France. FAU - Fila, Marc AU - Fila M AUID- ORCID: 0000-0001-8857-7100 AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. AD - INSERM U1191, URMS 5203, CNRS, Institut de Genomique Fonctionnelle, University of Montpellier, Montpellier, France. FAU - Herman, Fanchon AU - Herman F AUID- ORCID: 0009-0000-8358-5320 AD - Epidemiology and Clinical Research Department, University Hospital, University of Montpellier, Montpellier, France. FAU - Audie, Marion AU - Audie M AD - IHU Liryc, Electrophysiology and Heart Modelling Institute, INSERM U1045, University of Bordeaux, Bordeaux, France. AD - Department of Pediatric and Adult Congenital Cardiology, M3C National Reference Center, Bordeaux University Hospital, Bordeaux, France. AD - Le Hillot Cardiac Rehabilitation Center, Pessac, France. FAU - Harambat, Jerome AU - Harambat J AD - Pediatric Nephrology Department, Bordeaux University Hospital, Bordeaux, France. AD - INSERM U897, Epidemiology and Biostatistics, ISPED, University of Bordeaux, Bordeaux, France. FAU - Llanas, Brigitte AU - Llanas B AD - Pediatric Nephrology Department, Bordeaux University Hospital, Bordeaux, France. FAU - Morin, Denis AU - Morin D AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. AD - INSERM U1191, URMS 5203, CNRS, Institut de Genomique Fonctionnelle, University of Montpellier, Montpellier, France. FAU - Djouadi, Nabila AU - Djouadi N AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. FAU - Matecki, Stefan AU - Matecki S AUID- ORCID: 0000-0002-1878-0936 AD - University of Montpellier, PhyMedExp, INSERM, CNRS UMR, Montpellier, France. AD - Department of Physiology, Pediatric Functional Exploration Laboratory, Montpellier University Hospital, Montpellier, France. FAU - Guillaumont, Sophie AU - Guillaumont S AUID- ORCID: 0000-0002-7960-4776 AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. AD - Pediatric Cardiology and Rehabilitation Unit, Institut-Saint-Pierre, Palavas-Les-Flots, France. FAU - Vincenti, Marie AU - Vincenti M AUID- ORCID: 0000-0002-8201-5024 AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. AD - University of Montpellier, PhyMedExp, INSERM, CNRS UMR, Montpellier, France. AD - Pediatric Cardiology and Rehabilitation Unit, Institut-Saint-Pierre, Palavas-Les-Flots, France. FAU - De La Villeon, Gregoire AU - De La Villeon G AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. AD - Pediatric Cardiology and Rehabilitation Unit, Institut-Saint-Pierre, Palavas-Les-Flots, France. FAU - Pommier, Victor AU - Pommier V AUID- ORCID: 0000-0001-7848-5536 AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. AD - Department of Pediatric and Congenital Cardiology, La Reunion University Hospital, Saint-Denis de La Reunion, France. FAU - Roussey, Gwenaelle AU - Roussey G AD - Specialized Pediatric Department, Nantes University Hospital, Nantes, France. FAU - Prigent, Solene AU - Prigent S AUID- ORCID: 0009-0005-2391-7764 AD - Department of Pediatric Cardiology and Pediatric Cardiac Surgery, FHU PRECICARE, Nantes University, CHU Nantes, Nantes, France. FAU - Baruteau, Alban-Elouen AU - Baruteau AE AUID- ORCID: 0000-0003-2548-7858 AD - Department of Pediatric Cardiology and Pediatric Cardiac Surgery, FHU PRECICARE, Nantes University, CHU Nantes, Nantes, France. AD - INSERM, l'Institut du Thorax, Nantes, France. FAU - Abassi, Hamouda AU - Abassi H AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. FAU - Andrianoely, Mathieu AU - Andrianoely M AUID- ORCID: 0009-0007-1025-7909 AD - IHU Liryc, Electrophysiology and Heart Modelling Institute, INSERM U1045, University of Bordeaux, Bordeaux, France. AD - Just Coaching, Paris, France. FAU - Tenenbaum, Julie AU - Tenenbaum J AUID- ORCID: 0000-0003-4486-2748 AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. FAU - Gavotto, Arthur AU - Gavotto A AUID- ORCID: 0000-0001-6485-7634 AD - Department of Specialized Pediatrics, Unit of Pediatric Cardiology and Nephrology, Montpellier University Hospital, France. AD - University of Montpellier, PhyMedExp, INSERM, CNRS UMR, Montpellier, France. FAU - Desir, Arielle AU - Desir A AD - Department of Pediatrics, Heart and Lung Center, Heart Research Institute, Children's National Hospital, Georges Washington University School of Medicine and Health Sciences, Washington, DC. FAU - Batterton, Mary-Kate AU - Batterton MK AD - Department of Pediatrics, Heart and Lung Center, Heart Research Institute, Children's National Hospital, Georges Washington University School of Medicine and Health Sciences, Washington, DC. FAU - Picot, Marie-Christine AU - Picot MC AUID- ORCID: 0000-0003-4204-7299 AD - Epidemiology and Clinical Research Department, University Hospital, University of Montpellier, Montpellier, France. FAU - Amedro, Pascal AU - Amedro P AUID- ORCID: 0000-0003-3649-0294 AD - IHU Liryc, Electrophysiology and Heart Modelling Institute, INSERM U1045, University of Bordeaux, Bordeaux, France. AD - Department of Pediatric and Adult Congenital Cardiology, M3C National Reference Center, Bordeaux University Hospital, Bordeaux, France. AD - Department of Pediatrics, Heart and Lung Center, Heart Research Institute, Children's National Hospital, Georges Washington University School of Medicine and Health Sciences, Washington, DC. CN - QUALIREHAB Study Group LA - eng SI - ClinicalTrials.gov/NCT04897672 GR - JTC-THCS 2024/European Joint Transnational Call/ PT - Journal Article PT - Multicenter Study DEP - 20260722 PL - United States TA - Clin J Am Soc Nephrol JT - Clinical journal of the American Society of Nephrology : CJASN JID - 101271570 SB - IM CIN - doi: 10.2215/CJN.0000001193 MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - Prospective Studies MH - *Cardiorespiratory Fitness MH - Exercise Test MH - *Renal Insufficiency, Chronic/physiopathology MH - *Oxygen Consumption PMC - PMC13668233 OTO - NOTNLM OT - CKD OT - biomarkers OT - cardiovascular disease OT - hypertension OT - pediatric nephrology COIS- Disclosure forms, as provided by each author, are available with the online version of the article at https://links.lww.com/CJN/C826. FIR - Guillaumont, Sophie IR - Guillaumont S FIR - Oubari, Omar IR - Oubari O FIR - Bourreau, Jerome IR - Bourreau J FIR - Calderon, Johanna IR - Calderon J FIR - Moniotte, Stephane IR - Moniotte S FIR - Hubrechts, Jelena IR - Hubrechts J FIR - Peiro-Molina, Esteban IR - Peiro-Molina E FIR - Rezola, Erika IR - Rezola E FIR - Manso, Begona IR - Manso B FIR - Onoro, Gonzalo IR - Onoro G FIR - Ferrer-Sargues, Francisco-Jose IR - Ferrer-Sargues FJ FIR - Bordessoule, Alice IR - Bordessoule A FIR - Gavotto, Arthur IR - Gavotto A FIR - Matecki, Stephan IR - Matecki S FIR - Audie, Marion IR - Audie M FIR - Jore, Cecile IR - Jore C FIR - Andrianoely, Mathieu IR - Andrianoely M FIR - Neyraud, Caroline IR - Neyraud C FIR - Huby, Anne-Cecile IR - Huby AC FIR - Tortigue, Marine IR - Tortigue M FIR - Venna, Alyssia IR - Venna A FIR - Desire, Arielle IR - Desire A FIR - Batterton, Mary-Kate IR - Batterton MK FIR - Hershenson, Jared IR - Hershenson J FIR - Burton, Justin IR - Burton J FIR - D'Udekem, Yves IR - D'Udekem Y FIR - Amedro, Pascal IR - Amedro P EDAT- 2026/07/22 18:37 MHDA- 2026/10/09 11:39 PMCR- 2026/10/01 CRDT- 2026/07/22 12:03 PHST- 2026/03/03 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/10/09 11:39 [medline] PHST- 2026/07/22 18:37 [pubmed] PHST- 2026/07/22 12:03 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 01277230-990000000-00983 [pii] AID - CJASN-2026-000360 [pii] AID - 10.2215/CJN.0000001113 [doi] PST - ppublish SO - Clin J Am Soc Nephrol. 2026 Oct 1;21(10):1719-1732. doi: 10.2215/CJN.0000001113. Epub 2026 Jul 22. PMID- 42484982 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260820 IS - 2161-3311 (Electronic) IS - 2161-3311 (Linking) VI - 15 IP - 1 DP - 2026 Jul 22 TI - Feeding or Failing? Rethinking Nutrition Therapy in Pediatric Critical Care. LID - 10.1007/s13668-026-00785-x [doi] LID - 61 AB - PURPOSE OF REVIEW: Malnutrition, whether pre-existing or acquired in the ICU, is common in critically ill children. This narrative review synthesizes current evidence on nutritional assessment and therapy, highlighting how illness phase, underlying disease, and medical interventions influence energy expenditure and nutrient requirements. RECENT FINDINGS: International guidelines recommend comprehensive nutritional assessment and early initiation of enteral nutrition (EN) for all patients admitted to the Pediatric ICU. However, EN is frequently underutilized or insufficient to meet metabolic demands and sometimes contraindicated. Barriers to delivery persist, and parenteral nutrition (PN) may be required when EN is not feasible or adequate. Nutrition plays a crucial yet complex role in the care of critically ill children. Optimizing individualized nutrition strategies, including timely EN and appropriate PN use, is essential to improve clinical outcomes, support recovery, and enhance long-term rehabilitation, while highlighting the need for improved implementation and future research. CI - (c) 2026. The Author(s). FAU - Gallego Suarez, Cecilia AU - Gallego Suarez C AUID- ORCID: 0000-0002-4567-1030 AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Ave, mailstop 6010, suite 3100, Cleveland, OH, 44106, USA. Cecilia.GallegoSuarez@UHhospitals.org. FAU - Ponchak, Nora AU - Ponchak N AD - Department of Clinical Nutrition, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. FAU - Sankararaman, Senthilkumar AU - Sankararaman S AUID- ORCID: 0000-0003-3094-9703 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cleveland Clinic Children's Hospital, Cleveland, OH, USA. FAU - Pandey, Akash AU - Pandey A AUID- ORCID: 0000-0001-6924-4861 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Center for Digestive Health & Nutrition, Arnold Palmer Hospital for Children, Orlando, FL, USA. LA - eng PT - Journal Article PT - Review DEP - 20260722 PL - United States TA - Curr Nutr Rep JT - Current nutrition reports JID - 101587480 SB - IM MH - Humans MH - *Critical Illness/therapy MH - *Critical Care/methods MH - *Enteral Nutrition/methods MH - *Parenteral Nutrition/methods MH - Child MH - Intensive Care Units, Pediatric MH - Nutrition Assessment MH - *Malnutrition/therapy MH - Nutritional Requirements MH - Nutritional Status PMC - PMC13391708 OTO - NOTNLM OT - Enteral nutrition OT - Malnutrition OT - Parenteral nutrition OT - Pediatric critical illness OT - Rehabilitation COIS- Declarations. Informed Consent: Not applicable. Human and Animal Rights: This article does not contain any studies with human, or animal subjects performed by any of the authors. Institutional Review Board: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:38 PMCR- 2026/07/22 CRDT- 2026/07/22 11:16 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/22 12:38 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 11:16 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.1007/s13668-026-00785-x [pii] AID - 785 [pii] AID - 10.1007/s13668-026-00785-x [doi] PST - epublish SO - Curr Nutr Rep. 2026 Jul 22;15(1):61. doi: 10.1007/s13668-026-00785-x. PMID- 42484163 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1678-2690 (Electronic) IS - 0001-3765 (Linking) VI - 98 IP - 2 DP - 2026 TI - Analysis of Digital Phenotype for Classification of Self-Reported Anxiety. PG - e20250023 LID - S0001-37652026000202604 [pii] LID - 10.1590/0001-3765202620250023 [doi] AB - Digital phenotypes are behavioral patterns inferred from digital data, which have significantly contributed to eHealth research. Machine learning has proven effective in tracking these patterns; however, psychophysiological variables are still underutilized in identifying digital phenotypes. The objective of this study was to test the machine learning algorithms XGBoost, AdaBoost, RFC, and GaussianNB in classifying digital phenotypes of severe anxiety. Data from 360 volunteers, aged between 18 and 68 years of both sexes, were collected through self-report scales via the Neuropesquisa app, which simultaneously captured psychophysiological data, such as response time, accelerometer, and gyroscope readings. Scores from the DAAS-21 scale were used to identify individuals with severe anxiety. The results indicated that all four algorithms detected the digital phenotype with an accuracy greater than 75%. The RFC and GaussianNB classifiers achieved the highest accuracies, 81.48% and 80.56%, respectively, with f1 scores of 44.4% and 60.38%, and AUCs of 79% and 83% on the ROC curves. We conclude that the GaussianNB algorithm was the most effective in predicting the digital phenotype of severe anxiety. FAU - Meneses, Danilo A DE AU - Meneses DA AUID- ORCID: 0000-0002-1062-3549 AD - Universidade Federal da Paraiba, Centro de Ciencias Humanas, Letras e Artes, Programa de Pos-graduacao em Neurociencia Cognitiva e Comportamento, Cidade Universitaria, Campus I, Castelo Branco, 58051-900 Joao Pessoa, PB, Brazil. FAU - Bonato, Luiggi A B AU - Bonato LAB AUID- ORCID: 0000-0002-4068-2611 AD - Centro Universitario de Joao Pessoa, Department of Computer Science, Rodovia BR-230, Km 22, Agua Fria, 58053-000 Joao Pessoa, PB, Brazil. FAU - Meneses, Douglas A DE AU - Meneses DA AUID- ORCID: 0000-0001-6406-1361 AD - Centro Universitario de Joao Pessoa, Department of Computer Science, Rodovia BR-230, Km 22, Agua Fria, 58053-000 Joao Pessoa, PB, Brazil. FAU - Tavares, Joel Jonathan C AU - Tavares JJC AUID- ORCID: 0000-0001-9634-4884 AD - Universidade Federal da Paraiba, Centro de Ciencias Humanas, Letras e Artes, Programa de Pos-graduacao em Neurociencia Cognitiva e Comportamento, Cidade Universitaria, Campus I, Castelo Branco, 58051-900 Joao Pessoa, PB, Brazil. FAU - Lopez, Luiz Carlos S AU - Lopez LCS AUID- ORCID: 0000-0002-9983-5563 AD - Universidade Federal da Paraiba, Centro de Ciencias Humanas, Letras e Artes, Programa de Pos-graduacao em Neurociencia Cognitiva e Comportamento, Cidade Universitaria, Campus I, Castelo Branco, 58051-900 Joao Pessoa, PB, Brazil. LA - eng PT - Journal Article DEP - 20260720 PL - Brazil TA - An Acad Bras Cienc JT - Anais da Academia Brasileira de Ciencias JID - 7503280 SB - IM MH - Humans MH - Female MH - Classification Algorithms MH - Phenotype MH - Male MH - *Self Report MH - Adult MH - Adolescent MH - Middle Aged MH - *Anxiety/classification MH - Young Adult MH - Aged MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - Algorithms MH - ROC Curve EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:38 CRDT- 2026/07/22 08:46 PHST- 2025/01/07 00:00 [received] PHST- 2025/11/01 00:00 [accepted] PHST- 2026/07/22 12:38 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 08:46 [entrez] AID - S0001-37652026000202604 [pii] AID - 10.1590/0001-3765202620250023 [doi] PST - epublish SO - An Acad Bras Cienc. 2026 Jul 20;98(2):e20250023. doi: 10.1590/0001-3765202620250023. eCollection 2026. PMID- 42483876 OWN - NLM STAT- Publisher LR - 20260722 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) DP - 2026 Jul 22 TI - Assessing Consumer-Grade BIA for Minimum Wrestling Weight Determination in Boys High School Wrestling. LID - 10.1519/JSC.0000000000005601 [doi] AB - Jagim, AR, Twohey, E, Fields, JB, Shepler, C, and Jones, MT. Assessing consumer-grade BIA for minimum wrestling weight determination in boys high school wrestling. J Strength Cond Res XX(X): 000-000, 2026-Preseason weight certification in high school wrestling requires valid assessment of body fat percentage to calculate a minimum wrestling weight (MWW). Although skinfold (SKF) thickness is the standard method, bioelectrical impedance analysis (BIA) devices are widely used in school settings. The current study evaluated differences in body fat percentage (BF%), MWW, and resultant minimum weight class (MWC) between SKF and a consumer-grade multifrequency BIA (MFBIA) device. Thirty-six high school male wrestlers completed hydration assessment, weigh-in, SKF testing via a three-site model, and MFBIA assessment during a single afternoon session. Body fat percentage, fat-free mass (FFM), MWW, and resulting MWC were calculated according to state-sanctioned weight certification protocols. Estimates of BF% were higher for SKFBF% compared with the MFBIA% (SKF: 12.9 +/- 4.5%; MFBIA: 10.9 +/- 5.5%; p < 0.001), resulting in a mean difference of -2.1 +/- 3.2% (95% CI: -3.1 to -0.9). Skinfold-derived values were lower for MWW (SKF: 62.1 +/- 8.9 kg; MFBIA: 63.8 +/- 10.3 kg; p < 0.001) and FFM (SKF: 57.3 +/- 8.6 kg; MFBIA: 59.3 +/- 9.7 kg; p < 0.001) compared with MFBIA-derived values. This resulted in a mean difference of -1.7 +/- 2.4 kg (95% CI: -2.4 to -0.9) and -2.1 (95% CI: -2.76 to -1.2) for MWW and FFM, respectively. Approximately 56% of athletes (n = 20) were assigned to different MWCs depending on the method used. Although group-level %BF and MWW values were similar, the observed individual-level discrepancies indicate that the current consumer-grade MFBIA device should not be used interchangeably with the state-sanctioned SKF method for weight certification, and that BIA devices intended for regulatory use should be validated against the mandated field method or a laboratory-based criterion measure. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - Jagim, Andrew R AU - Jagim AR AD - Exercise and Sport Science Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin. FAU - Twohey, Eric AU - Twohey E AD - Sports Medicine, Olmsted Medical Center, Rochester, Minnesota. FAU - Fields, Jennifer B AU - Fields JB AD - Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut. FAU - Shepler, Christian AU - Shepler C AD - School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin; and. FAU - Jones, Margaret T AU - Jones MT AD - Sport, Recreation, and Tourism Management, George Mason University, Fairfax, Virginia. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM OTO - NOTNLM OT - athlete safety OT - bioelectrical impedance, wrestling, combat sports OT - body composition OT - weight certification EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:37 CRDT- 2026/07/22 05:43 PHST- 2026/07/22 12:37 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 05:43 [entrez] AID - 00124278-990000000-01137 [pii] AID - 10.1519/JSC.0000000000005601 [doi] PST - aheadofprint SO - J Strength Cond Res. 2026 Jul 22. doi: 10.1519/JSC.0000000000005601. PMID- 42483753 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 2040-1752 (Electronic) IS - 2040-1744 (Linking) VI - 17 DP - 2026 Jul 22 TI - Relative fat mass and myopia in adolescents: a cross-sectional study using NHANES data. PG - e33 LID - 10.1017/S204017442610066X [doi] AB - Adolescence is a peak period for myopia onset, which is closely related to environmental and lifestyle factors. Relative fat mass (RFM), a novel indicator of body fat, provides a more precise measure of adiposity. However, its relationship with myopia in adolescents remains poorly understood. To probe the connection between RFM and myopia in adolescents, this study included 8746 adolescents aged 12-19 years, utilizing data from the National Health and Nutrition Examination Survey (1999-2008). Myopia was defined as a spherical equivalent (SE) perceived family support --> self-efficacy --> physical exercise behavior" was only significant in nuclear families. CONCLUSION: This study reveals the internal mechanism and boundary conditions of the family sports environment influencing junior high school students' physical exercise behavior, and provides theoretical references and practical suggestions for families, schools and communities to jointly construct a sports support network and improve adolescents' physical exercise behavior. CI - Copyright (c) 2026 Zhang, Zhou, Wu, Ren and Fang. FAU - Zhang, Tingxiao AU - Zhang T AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Zhou, Wenlan AU - Zhou W AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Wu, Qi AU - Wu Q AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Ren, Wanyang AU - Ren W AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Fang, Yuxiang AU - Fang Y AD - School of Physical Education, Liaoning Normal University, Dalian, China. LA - eng PT - Journal Article DEP - 20260707 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13386413 OTO - NOTNLM OT - family sports environment OT - junior high school students OT - perceived family support OT - physical exercise behavior OT - self-efficacy OT - the chain mediating effect COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:38 PMCR- 2026/07/07 CRDT- 2026/07/22 04:24 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/22 12:38 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 04:24 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1821116 [doi] PST - epublish SO - Front Psychol. 2026 Jul 7;17:1821116. doi: 10.3389/fpsyg.2026.1821116. eCollection 2026. PMID- 42482093 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261023 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jul 21 TI - Eating behaviour phenotype in the MYT1L-related neurodevelopmental disorder: a deep phenotyping study using standardized questionnaires. LID - 10.1186/s13023-026-04497-x [doi] LID - 368 AB - BACKGROUND: The MYT1L-related neurodevelopmental disorder (MRND) is associated with global motor and language delay, intellectual disability, behavioural disturbances, epilepsy and frequent early-onset obesity. Eating disturbances have been reported but remain poorly characterized. A systematic characterization of the eating behaviour phenotype is essential to improve diagnosis and management. METHODS: We conducted a multicentre study including 21 French-speaking individuals with a molecularly confirmed MRND and either overweight/obesity or eating behaviour disturbances. Eating behaviours were reported by relatives using validated questionnaires widely employed in rare obesity research: the Dykens Hyperphagia Questionnaire (HQ), the Trousseau Impulsivity Questionnaire, the Children's Eating Behaviour Questionnaire (CEBQ), the Food Cravings Questionnaire-Trait-reduced (FCQ-T-r, adults only), and a Visual Analogue Scale (VAS) for hunger. When available, questionnaire results were compared with published studies using the same instruments. RESULTS: Persistent hyperphagic behaviours were identified in the majority of patients, with the HQ questionnaire highlighting sustained food-seeking behaviours and pervasive food preoccupation. The mean global score was 25.9, indicating a moderate yet sustained hyperphagic profile. CEBQ revealed a strong attraction to food combined with reduced satiety responsiveness and rapid eating. Hunger was reported as persistent throughout the day. In children food impulsivity was less frequent (5/14; 36%) and no correlation was found between impulsivity and hyperphagia severity, contrasting with findings in other obesity syndromes. Among adults, 62.5% had scores suggestive of food addiction (FCQ-T-r >/= 50). CONCLUSION: This study delineates an eating behaviour profile in a symptom-enriched subgroup of individuals with MRND, characterized by moderate but sustained hyperphagia, persistent hunger, impaired satiety, low food-related impulsivity in children but frequent food craving/addiction in adults. These findings support early, age-adapted and multidisciplinary management strategies and highlight the need for targeted interventions to reduce the burden on affected individuals and families. CI - (c) 2026. The Author(s). FAU - Coursimault, Juliette AU - Coursimault J AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. j.coursimault@chu-rouen.fr. FAU - Guillon, Emilie AU - Guillon E AD - Nutrition Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France. AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. FAU - Lecoquierre, Francois AU - Lecoquierre F AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Charbonnier, Camille AU - Charbonnier C AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Guerrot, Anne-Marie AU - Guerrot AM AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Goldenberg, Alice AU - Goldenberg A AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Nicolas, Gael AU - Nicolas G AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Schaefer, Elise AU - Schaefer E AD - Service de Genetique Medicale, Institut de Genetique Medicale d'Alsace (IGMA), Hopitaux Universitaires de Strasbourg, Strasbourg, France. FAU - Ayrolles, Anael AU - Ayrolles A AD - Department of Child and Adolescent Psychiatry, APHP.Nord, Robert Debre University Hospital, Paris Cite University, Paris, France. FAU - Delorme, Richard AU - Delorme R AD - Department of Child and Adolescent Psychiatry, APHP.Nord, Robert Debre University Hospital, Paris Cite University, Paris, France. FAU - Riccardi, Florence AU - Riccardi F AD - Genetique Medicale, Centre Hospitalier Intercommunal Toulon - La Seyne- sur-Mer, Toulon, France. FAU - Grelet, Maude AU - Grelet M AD - Genetique Medicale, Centre Hospitalier Intercommunal Toulon - La Seyne- sur-Mer, Toulon, France. FAU - Caumes, Roseline AU - Caumes R AD - Universite de Lille, CHU de Lille, Clinique de Genetique <>, EA7364 RADEMEF-59000, Lille, France. FAU - Nizon, Mathilde AU - Nizon M AD - Service de Genetique Medicale, CHU Nantes, Nantes, France. FAU - Isidor, Bertrand AU - Isidor B AD - Service de Genetique Medicale, CHU Nantes, Nantes, France. FAU - Jouret, Guillaume AU - Jouret G AD - National Center of Genetics (NCG), Laboratoire National de Sante (LNS), Dudelange, L- 3555, Luxembourg. FAU - Rooryck, Caroline AU - Rooryck C AD - Univ. Bordeaux, MRGM INSERM U1211, CHU de Bordeaux, Service de Genetique Medicale, Bordeaux, F-33000, France. FAU - Amiel, Jeanne AU - Amiel J AD - Service de Medecine Genomique des Maladies Rares, Hopital Necker- Enfants Malades, AP-HP, Paris, France. FAU - Alaix, Anne-Sophie AU - Alaix AS AD - Service de Medecine Genomique des Maladies Rares, Hopital Necker- Enfants Malades, AP-HP, Paris, France. FAU - Morel, Victor AU - Morel V AD - Department of Medical Genetics, La Timone Hospital, AP-HM, La Timone Children's Hospital, Marseille, France. FAU - Jacquinet, Adeline AU - Jacquinet A AD - Department of Genetics, Sart Tilman University Hospital, Liege, Belgium. FAU - Mignot, Cyril AU - Mignot C AD - Departement de Genetique, Groupe Hospitalier Pitie-Salpetriere-Hopital Trousseau Centre de Reference Deficiences Intellectuelles de Causes Rares, APHP.Sorbonne Universite, Paris, France. FAU - Faivre, Laurence AU - Faivre L AD - Universite Bourgogne Europe, CHU Dijon Bourgogne, Inserm, CTM UMR1231, equipe GAD, FHU TRANSLAD, Centre de genetique, Centre de reference Anomalies du Developpement et Syndromes Malformatifs, Centre de reference Deficiences Intellectuelles de Causes Rares, et Centre de reference GenoPsy, Dijon, 21000, France. FAU - Fraile-Caietta, Emilie AU - Fraile-Caietta E AD - Service de pediatrie, Centre Hospitalier de Toulon, Toulon, France. FAU - Chalopin, Sarah AU - Chalopin S AD - Nutrition Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France. AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. FAU - Dubern, Beatrice AU - Dubern B AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. AD - Nutrition and Gastroenterology Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Trousseau Hospital, Paris, France. FAU - Poitou, Christine AU - Poitou C AD - Nutrition Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France. AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260721 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Female MH - Surveys and Questionnaires MH - *Feeding Behavior/physiology MH - *Neurodevelopmental Disorders/genetics/physiopathology/metabolism MH - Child MH - Male MH - Phenotype MH - Adult MH - Hyperphagia/genetics MH - Child, Preschool MH - Adolescent MH - Obesity/genetics MH - Feeding and Eating Disorders/genetics MH - Young Adult PMC - PMC13685170 OTO - NOTNLM OT - MYT1L haploinsufficiency OT - 2p25.3 deletion OT - Deep phenotypic characterization OT - Dykens OT - Eating behaviours OT - Rare disease OT - Standardized questionnaires OT - Syndromic obesity COIS- Declarations. Ethics approval and consent to participate: All patients gave their consent to participate in the study. This study expands on the 2022 cohort published by Coursimault et al., approved by the Institutional Review Board of the Rouen University Hospital (CERDE, Comite d'Ethique pour la Recherche sur Donnees Existantes et Hors Loi Jarde, Rouen, France) (notification n degrees 69-2020). Some patients were included as part of the French Rare Obesity Cohorts With Food Behavioural Disorders: Better Diagnosis for Better Treatment (ObeRare) cohort (NCT04604626). Consent for publication: Not applicable. Competing interests: JC has nothing to disclose. All other collaborators do not have anything to disclose. BD has nothing to disclose. Rhythm Pharmaceuticals provided financial support for data entry in the ObeRar database but had no role in the scientific aspects of the study, including data analysis, results, or their interpretation. EDAT- 2026/07/22 12:37 MHDA- 2026/10/21 05:32 PMCR- 2026/07/21 CRDT- 2026/07/21 23:50 PHST- 2026/10/21 05:32 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 23:50 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.1186/s13023-026-04497-x [pii] AID - 4497 [pii] AID - 10.1186/s13023-026-04497-x [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jul 21;21(1):368. doi: 10.1186/s13023-026-04497-x. PMID- 42481992 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261022 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 21 TI - Targeting childhood malaria: insights from multi-country DHS data in Sub-Saharan Africa. LID - 10.1186/s12887-026-07245-z [doi] LID - 1021 AB - BACKGROUND: Malaria remains a major public health challenge in sub-Saharan Africa, disproportionately affecting children under five and pregnant women. Understanding the socio-demographic and maternal determinants of malaria across multiple countries is critical for designing targeted interventions such as Targeted Drug Administration (TDA), Perennial Malaria Chemoprevention (PMC), Seasonal Malaria Chemoprevention (SMC), Vector Control and Epidemiological Mapping. This study aimed to assess the prevalence and determinants of malaria infection among children under five across seven sub-Saharan African countries and to identify country-specific risk factors. METHODS: A cross-sectional analytical study used secondary data from the most recent Demographic and Health Surveys (DHS-8) for Burkina Faso, Cote d'Ivoire, Kenya, Mozambique, Senegal, Tanzania, and for Cameroon, Malaria Indicator Surveys (MIS-8) was used. Two outcome measures were defined: malaria infection based on rapid diagnostic test (RDT) results (five countries: Burkina Faso, Cote d'Ivoire, Mozambique, Tanzania and Cameroon) and maternal self-report (seven countries: Burkina Faso, Cote d'Ivoire, Kenya, Mozambique, Senegal, Tanzania and Cameroon). The data were analyzed using Stata/SE 17.0 and the analytic samples included 20,323 mother-child pairs for RDT analysis and 12,457 for self-reported analysis. The study examined socio-demographic and maternal characteristics, including residence, wealth index, education, parity, body mass index (BMI), and pregnancy status. Analyses incorporated sampling weights and survey design. Descriptive statistics, chi-square tests, and country-specific multivariable logistic regression models were used to identify independent predictors. RESULTS: Malaria prevalence was higher by self-report (33.5%) than by RDT diagnosis (25.2%), with consistently higher self-reported estimates across Tanzania (31.7% vs. 6.9%), Burkina Faso (58.3% vs. 27.4%), and Cote d'Ivoire (47.1% vs. 36.9%). RDT-confirmed malaria showed stronger and more consistent associations with key risk factors, including rural residence (in Burkina Faso aOR = 3.58, in Cote d'Ivoire aOR = 3.64, in Mozambique aOR = 5.74, in Tanzania aOR = 12.70; all p < 0.001), wealth status has lower malaria risk (richest quintile: Burkina Faso aOR = 0.43, Cote d'Ivoire aOR = 0.26, Mozambique aOR = 0.14, Tanzania aOR = 0.27), and while pregnancy status has significant risk (in Burkina Faso p = 0.008, in Cote d'Ivoire p = 0.005, in Cameroon p = 0.006, and in Mozambique p < 0.001), compared with weaker and sometimes inconsistent self-reported associations. The RDT- malaria diagnosis produced more plausible and statistically robust associations (in Mozambique age 25-34: aOR = 1.32, p = 0.040; in Burkina Faso parity two births: aOR = 1.33, p < 0.001), whereas self-reported malaria showed weaker or contradictory effects suggesting potential misclassification and reporting bias in self-reported diagnosis. CONCLUSION: This study demonstrates that important methodological and epidemiological differences exist between self-reported malaria and malaria RDT diagnosis across sub-Saharan African countries. Self-reported malaria showed overestimated malaria prevalence and produced weaker and less consistent associations with established risk factors, indicating limited reliability for identifying true malaria infection patterns. In contrast, malaria RDT diagnosis generated more coherent and epidemiologically plausible associations with rural residence, socioeconomic status, nutritional status, and pregnancy, reflecting more accurately the biological and environmental determinants of malaria transmission. CI - (c) 2026. The Author(s). FAU - Konja, Benjamin Akwasi AU - Konja BA AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Agyapong, Nana Ama Frimpomaa AU - Agyapong NAF AD - Department of Clinical Nutrition and Dietetics, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Ocran, Emmanuel Kweku AU - Ocran EK AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Anyimadu, Gloria AU - Anyimadu G AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Agyapong, Livingstone AU - Agyapong L AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Asare, Kwame Kumi AU - Asare KK AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. kwame.asare@ucc.edu.gh. AD - Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana. kwame.asare@ucc.edu.gh. LA - eng PT - Journal Article DEP - 20260721 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Antimalarials) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Infant MH - Prevalence MH - *Malaria/epidemiology/prevention & control/diagnosis MH - Child, Preschool MH - Risk Factors MH - Male MH - Africa South of the Sahara/epidemiology MH - Adult MH - Secondary Data Analysis MH - Pregnancy MH - Health Surveys MH - Antimalarials/therapeutic use MH - Young Adult PMC - PMC13681905 OTO - NOTNLM OT - Children under five OT - DHS OT - Malaria OT - Multi-country analysis OT - Socio-demographic determinants OT - Sub-Saharan Africa COIS- Declarations. Ethics approval and consent to participate: The DHS surveys obtain ethical approval from the Institutional Review Board (IRB) of ICF and relevant national ethics committees in participating countries. Informed consent is obtained from all respondents prior to participation. This study utilized publicly available, de-identified secondary data obtained from the DHS Program upon formal request and approval. As the data contain no personal identifiers, additional ethical approval was not required for this secondary analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/22 12:37 MHDA- 2026/10/20 05:30 PMCR- 2026/07/21 CRDT- 2026/07/21 23:45 PHST- 2026/03/14 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/10/20 05:30 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 23:45 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.1186/s12887-026-07245-z [pii] AID - 7245 [pii] AID - 10.1186/s12887-026-07245-z [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 21;26(1):1021. doi: 10.1186/s12887-026-07245-z. PMID- 42480810 OWN - NLM STAT- Publisher LR - 20260909 IS - 1873-4332 (Electronic) IS - 1083-3188 (Linking) DP - 2026 Jul 21 TI - Systemic Immune-Inflammation Indices in Adolescents with Polycystic Ovary Syndrome (Recently Proposed as Polyendocrine Metabolic Ovarian Syndrome): Evidence from Obese and Nonobese Phenotypes. LID - S1083-3188(26)00456-0 [pii] LID - 10.1016/j.jpag.2026.07.008 [doi] AB - PURPOSE: This study aimed to evaluate the systemic immune-inflammation index (SII) and pan-immune-inflammation value (PIV) in adolescents with polycystic ovary syndrome (PCOS) and to investigate whether these markers reflect an inflammatory state independent of obesity. METHODS: A total of 140 adolescents (64 PCOS, 76 controls) were included. The groups were further subdivided based on BMI percentiles into obese (Group 1a: PCOS-obese, Group 2a: Control-obese) and nonobese (Group 1b: PCOS-nonobese, Group 2b: Control-nonobese) subgroups. Diagnosis of PCOS was based on the 2023 international evidence-based guidelines for adolescents. SII and PIV were calculated from complete blood count parameters. RESULTS: SII and PIV levels were significantly higher in the PCOS group compared to controls (P = .001 and P = .004, respectively). In subgroup analysis, SII remained significantly elevated in nonobese PCOS patients compared to nonobese controls (582.39 +/- 276.52 vs 406.44 +/- 116.73, P = .001). Multivariate logistic regression analysis identified SII as an independent predictor for PCOS (P = .019). Receiver operating characteristic analysis showed moderate diagnostic performance for SII (area under the curve [AUC]: 0.672) and PIV (AUC: 0.655). CONCLUSION: SII and PIV are elevated in adolescent PCOS independently of obesity, particularly in the nonobese phenotype. These cost-effective, hemogram-derived indices provide a valuable clinical snapshot of the systemic inflammatory burden and may provide insight into the inflammatory milieu associated with PCOS in adolescence for future metabolic complications. CI - Copyright (c) 2026 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved. FAU - Ciftci, Nurdan AU - Ciftci N AD - Department of Pediatrics Endocrinology, Konya City Hospital, Konya, Turkiye. Electronic address: pediatrinurdan@gmail.com. FAU - Akin, Sule Betul Nursacan AU - Akin SBN AD - Department of Pediatrics, Konya City Hospital, Konya, Turkiye. FAU - Dogan, Dilara AU - Dogan D AD - Department of Pediatrics, Konya City Hospital, Konya, Turkiye. FAU - Gulyuz, Abdulgani AU - Gulyuz A AD - Department of Pediatrics, Malatya Training and Research Hospital, Malatya, Turkiye. LA - eng PT - Journal Article DEP - 20260721 PL - United States TA - J Pediatr Adolesc Gynecol JT - Journal of pediatric and adolescent gynecology JID - 9610774 SB - IM OTO - NOTNLM OT - Adolescent OT - Obesity OT - PCOS OT - PIV OT - PMOS OT - SII COIS- Conflicts of Interest The authors have no relevant financial or nonfinancial interests to disclose. EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:37 CRDT- 2026/07/21 19:12 PHST- 2026/04/29 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 12:37 [medline] PHST- 2026/07/21 19:12 [entrez] AID - S1083-3188(26)00456-0 [pii] AID - 10.1016/j.jpag.2026.07.008 [doi] PST - aheadofprint SO - J Pediatr Adolesc Gynecol. 2026 Jul 21:S1083-3188(26)00456-0. doi: 10.1016/j.jpag.2026.07.008. PMID- 42480688 OWN - NLM STAT- MEDLINE DCOM- 20260905 LR - 20260905 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 217 DP - 2026 Nov TI - Cannabis-derived food products: a global review of THC exposure, safety and forensic frameworks. PG - 116285 LID - S0278-6915(26)00359-5 [pii] LID - 10.1016/j.fct.2026.116285 [doi] AB - Cannabis-derived food products range from nutritionally oriented hempseed foods to edible and drinkable products intentionally formulated with cannabinoids. This review integrates evidence on hemp foods, CBD-containing products, THC edibles, cannabis-infused beverages, and emerging cannabinoids such as Delta8-THC and HHC. Hemp seeds, oils, flours, and proteins provide valuable nutrients, including polyunsaturated fatty acids, proteins, fiber, minerals, and bioactive compounds, but require control of cannabinoid contamination, particularly total Delta9-THC. In contrast, cannabinoid-containing edibles act as pharmacologically active food-like exposure systems. Oral Delta9-THC presents a distinct toxicological profile characterized by delayed onset, prolonged effects, first-pass metabolism, formation of active 11-hydroxy-THC, and high interindividual variability. These features increase the risk of repeated dosing, unexpected intoxication, accidental pediatric exposure, emergency presentations, and forensic interpretation challenges. CBD products raise safety concerns related to dose, purity, liver effects, drug interactions, and vulnerable populations, while Delta8-THC, HHC, and related cannabinoids introduce additional uncertainty due to limited toxicological data and inconsistent regulation. Harmonized definitions, validated analytical methods, reliable labeling, child-resistant packaging, adverse-event surveillance, and dose-based regulation are needed to protect consumers and support public safety. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Jurowski, Kamil AU - Jurowski K AD - Department of Toxicology, Faculty of Medicine, Collegium Medicum, University of Rzeszow, al. Tadeusza Rejtana 16C, Rzeszow, 35-959, Poland; Department of Regulatory and Forensic Toxicology, Institute of Medical Expertise, ul. Aleksandrowska 67/93, Lodz, 91-205, Poland; Laboratory of Toxicological Research and Analyses, Faculty of Medicine, Collegium Medicum, University of Rzeszow, Al. mjr. W. Kopisto 2a, Rzeszow, 35-959, Poland; Centre for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, CZ-500 03, Czech Republic. Electronic address: toksykologia@ur.edu.pl. FAU - Noga, Maciej AU - Noga M AD - Department of Toxicology, Faculty of Medicine, Collegium Medicum, University of Rzeszow, al. Tadeusza Rejtana 16C, Rzeszow, 35-959, Poland. FAU - Kobylarz, Damian AU - Kobylarz D AD - Department of Toxicology, Faculty of Medicine, Collegium Medicum, University of Rzeszow, al. Tadeusza Rejtana 16C, Rzeszow, 35-959, Poland. FAU - Niznik, Lukasz AU - Niznik L AD - Department of Toxicology, Faculty of Medicine, Collegium Medicum, University of Rzeszow, al. Tadeusza Rejtana 16C, Rzeszow, 35-959, Poland. FAU - Machlanska, Agnieszka AU - Machlanska A AD - Department of Forensic Medical Traumatology, Institute of Medical Expertise, ul. Aleksandrowska 67/93, Lodz, 91-205, Poland. FAU - Nepovimova, Eugenie AU - Nepovimova E AD - Center of Advanced Innovation Technologies, VSB-Technical University of Ostrava, Ostrava-Poruba, 708 00, Czech Republic; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, 50003, Czech Republic. FAU - Kuca, Kamil AU - Kuca K AD - Centre for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, CZ-500 03, Czech Republic; Center of Advanced Innovation Technologies, VSB-Technical University of Ostrava, Ostrava-Poruba, 708 00, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, 50005, Czech Republic. LA - eng PT - Journal Article PT - Review DEP - 20260721 PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 RN - 7J8897W37S (Dronabinol) RN - 0 (Cannabinoids) SB - IM MH - Humans MH - *Cannabis/chemistry MH - *Dronabinol/analysis/toxicity MH - Cannabinoids/analysis/toxicity MH - Animals MH - Food Contamination/analysis OTO - NOTNLM OT - Cannabinoids OT - Cannabis-derived foods OT - Edible cannabis OT - Food safety OT - Forensic toxicology OT - Toxicology OT - Delta9-THC COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kamil Jurowski reports a relationship with Elsevier Inc that includes: board membership. I serve as Managing Editor for RIFM submissions in Food and Chemical Toxicology. I was not involved in the editorial handling, peer review, or decision-making process for this manuscript. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/22 12:37 MHDA- 2026/09/06 01:18 CRDT- 2026/07/21 19:11 PHST- 2026/06/05 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/18 00:00 [accepted] PHST- 2026/09/06 01:18 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 19:11 [entrez] AID - S0278-6915(26)00359-5 [pii] AID - 10.1016/j.fct.2026.116285 [doi] PST - ppublish SO - Food Chem Toxicol. 2026 Nov;217:116285. doi: 10.1016/j.fct.2026.116285. Epub 2026 Jul 21. PMID- 42480622 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1872-9649 (Electronic) IS - 1568-1637 (Linking) VI - 121 DP - 2026 Oct TI - Microbiome remodeling during aging: Integrative multi-omics and spatiotemporal perspectives on immune and metabolic regulation. PG - 103269 LID - S1568-1637(26)00261-8 [pii] LID - 10.1016/j.arr.2026.103269 [doi] AB - Changes in the gut microbiota occur throughout the human lifespan, and maintaining microbial homeostasis plays a critical role in promoting healthy aging. In recent years, substantial progress has been made in elucidating the mechanistic links between aging and microbiota remodeling, highlighting the central role of microbiota-host interactions in regulating immune responses and maintaining metabolic homeostasis. These findings provide new potential targets for the precision prevention and treatment of age-related diseases. This review systematically summarizes the patterns of gut microbiota succession across different stages of the human life cycle, including infancy, adolescence, adulthood, and old age, as well as the mechanisms through which the microbiota regulates immune and metabolic functions. Furthermore, the role of the gut microbiota as a key mediator linking aging with an increased risk of chronic inflammation, cardiovascular disease, cognitive impairment, neurodegenerative disorders, and cancer was explored. In addition, this review evaluates the therapeutic potential of microbiota-targeted interventions, such as dietary modification, probiotic and prebiotic supplementation, fecal microbiota transplantation (FMT), and lifestyle interventions-in maintaining microbiome homeostasis and mitigating age-related diseases. The feasibility of personalized microbiota-based intervention strategies is also discussed. Finally, we highlight the current challenges and limitations in this field and outline future research directions. In particular, integrating multi-omics approaches with metagenomic sequencing, including emerging spatial and spatiotemporal multi-omics technologies, is crucial for advancing our understanding of the complex interactions within the gut microbiome. These insights provide a theoretical framework for optimizing anti-aging therapeutic strategies and promoting healthy lifespan extension. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Ren, Xinyue AU - Ren X AD - Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. FAU - Ma, Jingwen AU - Ma J AD - College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning, China. FAU - Zhao, Yijie AU - Zhao Y AD - Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. FAU - Yang, Mingyu AU - Yang M AD - College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning, China. FAU - Li, Yilin AU - Li Y AD - College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning, China. FAU - Song, Wei AU - Song W AD - Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. FAU - Wang, Nan AU - Wang N AD - Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. Electronic address: wangnanlab@163.com. LA - eng PT - Journal Article PT - Review DEP - 20260721 PL - England TA - Ageing Res Rev JT - Ageing research reviews JID - 101128963 SB - IM MH - Humans MH - *Aging/immunology/metabolism MH - Multiomics MH - *Gastrointestinal Microbiome/physiology/immunology MH - Animals MH - Homeostasis OTO - NOTNLM OT - Aging OT - Gut microbiota OT - Intervention OT - Probiotics COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/22 12:37 MHDA- 2026/08/25 23:33 CRDT- 2026/07/21 19:10 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/25 23:33 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 19:10 [entrez] AID - S1568-1637(26)00261-8 [pii] AID - 10.1016/j.arr.2026.103269 [doi] PST - ppublish SO - Ageing Res Rev. 2026 Oct;121:103269. doi: 10.1016/j.arr.2026.103269. Epub 2026 Jul 21. PMID- 42480192 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260905 IS - 1879-1484 (Electronic) IS - 0021-9150 (Linking) VI - 420 DP - 2026 Sep TI - Universal paediatric screening for familial hypercholesterolaemia: Lessons learnt from our pilot study EARLIE. PG - 120838 LID - S0021-9150(26)00204-2 [pii] LID - 10.1016/j.atherosclerosis.2026.120838 [doi] AB - BACKGROUND AND AIMS: Universal screening for familial hypercholesterolaemia (FH) has been proposed; but implementation remains limited. This pilot study assesses the feasibility and efficacy of a screening based on a capillary blood test in children during a school medical visit. Additionally, we review published screening strategies and cut-off values. METHODS: Screening consisted of a questionnaire and capillary blood test in children aged 7-12 years. Further diagnostic work-up (fasting blood test under low-cholesterol diet and genetic analysis) was proposed if total cholesterol (TC) > 230 mg/dL (>5.9 mmol/L) and/or low-density lipoprotein cholesterol (LDL) > 160 mg/dL (>4.1 mmol/L). If FH was confirmed, the child was commenced on lipid-lowering therapy, and reverse cascade screening was performed within the family. RESULTS: 1860 children of 3733 invited children participated (49.8%). 30 refused the blood test (1.6%). Median TC was 158 mg/dL (4.1 mmol/L; Q25/75,141/174 [3.6/4.5]; P99 230 [5.9]); median LDL 74 mg/dL (1.9 mmol/L; 61/89 [1.6/2.3]; 139 [3.6]). Recall rate 1%. In the sub-cohort with LDL >160 mg/dL (>4.1 mmol/L), (n = 6): detection of three pathogenic variants and five additional affected family members, while three declined further follow-up. CONCLUSIONS: FH screening based on a capillary lipid panel is an efficient screening method. However, 50% of highly suspicious cases declined further follow-up. We therefore advocate screening in the presence of parents to allow discussion of the results and explanation of further diagnostic work-up and long-term health risks. Cut-off levels should be adapted to the methodology used and re-evaluated during the course of the screening programme. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Becker, Marianne AU - Becker M AD - Department of Paediatric Endocrinology and Diabetology, Centre Hospitalier de Luxembourg, Luxembourg; Vitality Research Group, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: becker.marianne@chl.lu. FAU - Bocquet, Valery AU - Bocquet V AD - Competence Center for Methodology and Statistics, Luxembourg Institute of Health, Luxembourg. FAU - Fandel, Francoise AU - Fandel F AD - Department of School Medicine, City of Luxembourg, Luxembourg. FAU - Adamski, Aurelie AU - Adamski A AD - Department of Paediatric Endocrinology and Diabetology, Centre Hospitalier de Luxembourg, Luxembourg. FAU - Vaillant, Michel AU - Vaillant M AD - Competence Center for Methodology and Statistics, Luxembourg Institute of Health, Luxembourg. FAU - Wagner, Kerstin AU - Wagner K AD - Department of Paediatric Cardiology, Centre Hospitalier de Luxembourg, Luxembourg. FAU - Droste, Dirk W AU - Droste DW AD - Department of Neurology, Centre Hospitalier de Luxembourg, Luxembourg. FAU - Hein, Steve AU - Hein S AD - Department of Sports Medicine, Centre Hospitalier de Luxembourg, Luxembourg. FAU - Gies, Inge AU - Gies I AD - Vitality Research Group, Vrije Universiteit Brussel, Brussels, Belgium; Department of Paediatrics, Universitair Ziekenhuis Brussel, Brussels, Belgium. FAU - Mendon, Priyanka AU - Mendon P AD - Competence Center for Methodology and Statistics, Luxembourg Institute of Health, Luxembourg. FAU - de Beaufort, Carine AU - de Beaufort C AD - Department of Paediatric Endocrinology and Diabetology, Centre Hospitalier de Luxembourg, Luxembourg; Faculty of Science, Technology and Medicine, University of Luxemburg, Esch-Belval, Luxembourg. LA - eng PT - Journal Article DEP - 20260714 PL - Ireland TA - Atherosclerosis JT - Atherosclerosis JID - 0242543 RN - 0 (Cholesterol, LDL) RN - 0 (Biomarkers) RN - 97C5T2UQ7J (Cholesterol) SB - IM MH - Humans MH - Child MH - Pilot Projects MH - *Hyperlipoproteinemia Type II/diagnosis/blood/genetics MH - Male MH - Female MH - Cholesterol, LDL/blood MH - *Mass Screening/methods MH - Surveys and Questionnaires MH - Biomarkers/blood MH - Feasibility Studies MH - Cholesterol/blood MH - Predictive Value of Tests MH - Genetic Predisposition to Disease MH - Genetic Testing OTO - NOTNLM OT - Familial hypercholesterolaemia OT - Paediatric screening OT - Universal screening COIS- Declaration of competing interest MB received travel grants from Novo Nordisk and Kyowa Kirin and honoraria for lectures from Novo Nordisk. IG, DD, AA, KW, MV, VB, PM, FF, SH and CdB have nothing to declare. EDAT- 2026/07/22 12:37 MHDA- 2026/08/28 11:40 CRDT- 2026/07/21 18:02 PHST- 2026/01/13 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/08/28 11:40 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 18:02 [entrez] AID - S0021-9150(26)00204-2 [pii] AID - 10.1016/j.atherosclerosis.2026.120838 [doi] PST - ppublish SO - Atherosclerosis. 2026 Sep;420:120838. doi: 10.1016/j.atherosclerosis.2026.120838. Epub 2026 Jul 14. PMID- 42479927 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260824 IS - 1744-6171 (Electronic) IS - 1073-6077 (Print) IS - 1073-6077 (Linking) VI - 39 IP - 3 DP - 2026 Aug TI - A Mobile Application to Improve Mental Health and Reduce Suicidal Ideation Among Adolescents: A Pilot Mixed-Methods Study. PG - e70064 LID - 10.1111/jcap.70064 [doi] LID - e70064 AB - BACKGROUND: Adolescent suicidal ideation is a critical public health issue, with limited support options in low-resource settings. PURPOSE: This study aimed to evaluate the acceptability, usability, and preliminary effects of Emo-Safe, an Android-based application designed to enhance emotional regulation and reduce suicidal ideation among adolescents. METHODOLOGY: This study utilized a sequential, explanatory mixed-methods approach, consisting of quantitative followed by qualitative methods. Sixty students, aged 15-18, participated in the study, divided into an intervention group (n = 30) and a control group (n = 30) for 4 weeks. Core app features included daily mood tracking, reflective journaling with AI-assisted reframing guided by cognitive-behavioral therapy (CBT) principles, breathing exercises, personalized insights, and an AI "friend" for encouragement. Outcomes measured were the Indonesian Depression Anxiety Stress Scales for Youth (IDASS-Y) and the Suicidal Ideation Scale (SIS). RESULT: Results indicated that the intervention group had significantly lower post-test IDASS-Y scores (28.43 vs. 33.17; p = 0.037) and reduced stress levels (8.83 vs. 12.37; p = 0.001). The SIS also favored the intervention group (14.83 vs. 21.70; p < 0.001). Acceptability was high (mean rating 4.24/5) with positive feedback on material clarity and facilitator effectiveness, along with suggestions for improvements. CONCLUSIONS: Findings demonstrate the acceptability and usability of Emo-Safe, alongside promising short-term reductions in stress and suicidal ideation. However, further systematic evaluation of broader feasibility indicators, such as recruitment and long-term engagement, is needed in future trials. CI - (c) 2026 Wiley Periodicals LLC. FAU - Mundakir AU - Mundakir AUID- ORCID: 0000-0003-2255-3514 AD - Department of Nursing, Faculty of Health Sciences, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. FAU - Sukodiono AU - Sukodiono AUID- ORCID: 0000-0002-6349-7830 AD - Faculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. FAU - Hakim, M Hanifuddin AU - Hakim MH AD - Industrial Engineering Department, Faculty of Engineering, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. FAU - Fitriyani, Vika Ramadhana AU - Fitriyani VR AUID- ORCID: 0009-0008-1562-1711 AD - Department of Nursing, Faculty of Health Sciences, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. AD - College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Syarifurrahman, Islam AU - Syarifurrahman I AUID- ORCID: 0000-0001-6933-9836 AD - Department of Nursing, Faculty of Health Sciences, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. AD - College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Choliq, Idham AU - Choliq I AUID- ORCID: 0000-0001-5831-4342 AD - Department of Nursing, Faculty of Health Sciences, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. AD - College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Research Center for Community Health and Artificial Intelligence (RECHAI), Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. LA - eng GR - 128/C3/DT.05.00/PL/2025/Ministry of Higher Education, Science, and Technology, Indonesia/ PT - Journal Article PL - England TA - J Child Adolesc Psychiatr Nurs JT - Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc JID - 9431738 SB - IM MH - Humans MH - Adolescent MH - *Suicidal Ideation MH - Pilot Projects MH - Female MH - *Mobile Applications MH - Male MH - *Emotional Regulation MH - *Cognitive Behavioral Therapy/methods MH - *Mental Health MH - *Adolescent Behavior/psychology PMC - PMC13387718 OTO - NOTNLM OT - adolescents OT - application OT - mental health OT - pilot study OT - suicidal ideation COIS- The authors declare no conflicts of interest. EDAT- 2026/07/21 18:34 MHDA- 2026/07/21 18:35 PMCR- 2026/07/21 CRDT- 2026/07/21 15:32 PHST- 2026/06/12 00:00 [revised] PHST- 2026/01/13 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/21 18:35 [medline] PHST- 2026/07/21 18:34 [pubmed] PHST- 2026/07/21 15:32 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - JCAP70064 [pii] AID - 10.1111/jcap.70064 [doi] PST - ppublish SO - J Child Adolesc Psychiatr Nurs. 2026 Aug;39(3):e70064. doi: 10.1111/jcap.70064. PMID- 42478984 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260820 IS - 1221-9118 (Print) IS - 1221-9118 (Linking) VI - 121 IP - 3 DP - 2026 Jun TI - Anatomical and Molecular Insights into Sarcopenia in Liver Cirrhosis: A CT-Based and Biomarker Case-Control Study. PG - 309-320 LID - 8 [pii] LID - 10.21614/chirurgia.3325 [doi] AB - Background: Sarcopenia is a common complication and an important negative prognostic factor in patients with liver cirrhosis, being associated with reduced muscle mass and function, as well as increased mortality. Although computed tomography (CT) is considered the gold standard for assessing muscle mass, there is growing interest in identifying serum biomarkers that may facilitate the early diagnosis and monitoring of disease progression. The aim of this study was to evaluate the diagnostic value of osteonectin, the C-terminal agrin fragment (CAF), the N-terminal propeptide of type III procollagen (P3NP), and myostatin in patients with liver cirrhosis and sarcopenia, in correlation with CT-derived imaging parameters. Materials and Methods: A prospective observational caseacontrol study was conducted, including 60 participants: 30 patients with liver cirrhosis (with or without hepatocellular carcinoma) and sarcopenia, and 30 healthy control subjects. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria, using the skeletal muscle index (SMI) and psoas muscle index (PMI) measured by computed tomography. Serum concentrations of osteonectin, CAF, P3NP, and myostatin were determined using enzyme-linked immunosorbent assay (ELISA). Statistical analyses included parametric and non-parametric tests, as well as Pearson correlation analysis. Results: Patients with liver cirrhosis and sarcopenia exhibited significantly higher serum levels of osteonectin, CAF, P3NP, and myostatin compared with healthy controls (p 0.001 for all comparisons). The skeletal muscle index was significantly lower in cirrhotic patients, confirming the presence of muscle wasting. Correlation analysis demonstrated positive associations between osteonectin and CAF (r = 0.441, p 0.001), osteonectin and P3NP (r = 0.313, p = 0.016), osteonectin and myostatin (r = 0.444, p 0.001), as well as a strong correlation between CAF and myostatin (r = 0.882, p 0.001). No significant associations were observed between biomarker levels and viral etiology or ChildaPugh class. Conclusions: Simultaneous assessment of osteonectin, CAF, P3NP, and myostatin, combined with computed tomography-based imaging evaluation, may improve the diagnosis of sarcopenia associated with liver cirrhosis and facilitate the early identification of patients at increased risk of muscle deterioration. Larger multicenter prospective studies are warranted to validate the clinical utility of these biomarkers in routine medical practice. CI - Celsius. FAU - Gherghescu, Costel-George AU - Gherghescu CG FAU - Baz, Radu Andrei AU - Baz RA FAU - Dina, Constantin AU - Dina C FAU - Dumitru, Andrei AU - Dumitru A FAU - Cozaru, Georgeta Camelia AU - Cozaru GC FAU - Manea, Mihaela AU - Manea M FAU - Popescu, Ioana AU - Popescu I FAU - Grigorescu, Ana-Maria AU - Grigorescu AM FAU - Popescu, Stere AU - Popescu S FAU - Dumitru, Eugen AU - Dumitru E LA - eng PT - Journal Article PT - Observational Study PL - Romania TA - Chirurgia (Bucur) JT - Chirurgia (Bucharest, Romania : 1990) JID - 9213031 RN - 0 (Biomarkers) RN - 0 (Procollagen) RN - 0 (Osteonectin) RN - 0 (procollagen Type III-N-terminal peptide) RN - 0 (Myostatin) RN - 0 (Peptide Fragments) SB - IM MH - Humans MH - *Sarcopenia/blood/etiology/diagnosis/diagnostic imaging MH - Biomarkers/blood MH - Female MH - Male MH - *Liver Cirrhosis/complications/blood MH - Case-Control Studies MH - Prospective Studies MH - Procollagen/blood MH - *Tomography, X-Ray Computed MH - Osteonectin/blood MH - Middle Aged MH - Aged MH - *Myostatin/blood MH - Predictive Value of Tests MH - *Peptide Fragments/blood MH - Prognosis MH - Enzyme-Linked Immunosorbent Assay MH - Sensitivity and Specificity MH - Disease Progression OTO - NOTNLM OT - C-terminalagrinfragment OT - P3NP OT - biomarkers OT - computedtomography OT - fibrosis OT - livercirrhosis OT - musclewasting OT - myostatin OT - osteonectin OT - sarcopenia EDAT- 2026/07/21 12:35 MHDA- 2026/07/21 12:36 CRDT- 2026/07/21 10:13 PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/21 12:36 [medline] PHST- 2026/07/21 12:35 [pubmed] PHST- 2026/07/21 10:13 [entrez] AID - 8 [pii] AID - 10.21614/chirurgia.3325 [doi] PST - ppublish SO - Chirurgia (Bucur). 2026 Jun;121(3):309-320. doi: 10.21614/chirurgia.3325. PMID- 42478861 OWN - NLM STAT- Publisher LR - 20260721 IS - 1945-7197 (Electronic) IS - 0021-972X (Linking) DP - 2026 Jul 21 TI - Temporal stability of cardiometabolic risk factors from the perspective of primordial disease prevention in children. LID - dgag285 [pii] LID - 10.1210/clinem/dgag285 [doi] AB - CONTEXT AND OBJECTIVE: Excess adiposity and circulating lipoprotein lipids in childhood are predictive of cardiometabolic disease in adulthood. We analysed temporal tracking for body mass and lipid biomarkers using population-based time-series to assess the statistical feasibility of primordial prediction and prevention. DESIGN AND PARTICIPANTS: Individuals born between 1962-1992 were included from four European local community cohorts. Serial measurements of weight, height, waist and lipoprotein lipids were analysed for 12,212 participants (ages 5-49 years, follow-ups 15-31 years depending on cohort). Longitudinal tracking was quantified by autocorrelation R2 over the same individuals between any two visits in the series; the weakening of R2(Deltat) with increasing follow-up time was modelled by exponential decay. RESULTS: Based on the decay model, we calculated autocorrelation for two surveys fifteen years apart as a simplified tracking indicator: R2(15) = 35.7% for body-mass index, R2(15) = 28.1% for waist-height ratio and R2(15) = 32.5% for low-density lipoprotein (LDL) cholesterol. Total and high-density lipoprotein cholesterol were comparable to LDL cholesterol. Triglycerides exhibited weak tracking. The detection rate (DR5) at 5% false positive rate (FPR) of children who were in the top risk decile as adults was DR5(15) = 38.9% for body mass index and DR5(15) = 30.9% for LDL cholesterol. CONCLUSIONS: Individualised biomarker screening at low FPR misclassifies the majority of children who will have high values as adults (low statistical feasibility). Biomarker tracking is more useful for guiding broad population-based primordial prevention programmes that can be extended to all children at risk without harm from false positives. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Makinen, Ville-Petteri AU - Makinen VP AUID- ORCID: 0000-0002-7262-2656 AD - Systems Epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland. AD - Biocenter Oulu, University of Oulu, Oulu, Finland. FAU - Kahonen, Mika AU - Kahonen M AD - Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. AD - Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. FAU - Lehtimaki, Terho AU - Lehtimaki T AUID- ORCID: 0000-0002-2555-4427 AD - Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. AD - Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland. AD - Fimlab Laboratories, Pirkanmaa Hospital District, Finland. FAU - Hutri, Nina AU - Hutri N AD - Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. FAU - Ronnemaa, Tapani AU - Ronnemaa T AD - Department of Medicine, University of Turku, Turku, Finland. AD - Division of Medicine, Turku University Hospital, Turku, Finland. FAU - Viikari, Jorma AU - Viikari J AUID- ORCID: 0000-0001-6452-010X AD - Department of Medicine, University of Turku, Turku, Finland. AD - Division of Medicine, Turku University Hospital, Turku, Finland. FAU - Pahkala, Katja AU - Pahkala K AUID- ORCID: 0000-0001-9338-4397 AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. AD - Paavo Nurmi Centre, Unit of Health and Physical Activity, University of Turku, Turku, Finland. FAU - Rovio, Suvi AU - Rovio S AUID- ORCID: 0000-0003-0911-7478 AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. AD - Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland. FAU - Niinikoski, Harri AU - Niinikoski H AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. AD - Department of Pediatrics and Adolescent Medicine, Turku University Hospital, University of Turku, Turku, Finland. AD - Institute of Biomedicine, University of Turku, Turku, Finland. FAU - Mykkanen, Juha AU - Mykkanen J AUID- ORCID: 0000-0001-9898-2660 AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. FAU - Raitakari, Olli AU - Raitakari O AUID- ORCID: 0000-0001-9365-3702 AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. AD - Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital. AD - InFLAMES Research Flagship, University of Turku, Turku, Finland. FAU - Ala-Korpela, Mika AU - Ala-Korpela M AUID- ORCID: 0000-0001-5905-1206 AD - Systems Epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland. AD - Biocenter Oulu, University of Oulu, Oulu, Finland. AD - NMR Metabolomics Laboratory, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland. LA - eng PT - Journal Article DEP - 20260721 PL - United States TA - J Clin Endocrinol Metab JT - The Journal of clinical endocrinology and metabolism JID - 0375362 SB - IM OTO - NOTNLM OT - cardiovascular risk OT - disease prevention OT - lipid tracking OT - longitudinal OT - obesity EDAT- 2026/07/21 12:35 MHDA- 2026/07/21 12:35 CRDT- 2026/07/21 09:22 PHST- 2026/04/15 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/12 00:00 [accepted] PHST- 2026/07/21 12:35 [medline] PHST- 2026/07/21 12:35 [pubmed] PHST- 2026/07/21 09:22 [entrez] AID - 8739136 [pii] AID - 10.1210/clinem/dgag285 [doi] PST - aheadofprint SO - J Clin Endocrinol Metab. 2026 Jul 21:dgag285. doi: 10.1210/clinem/dgag285. PMID- 42477844 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260917 LR - 20260919 IS - 2662-2211 (Electronic) IS - 2662-2211 (Linking) VI - 7 IP - 1 DP - 2026 Jul 20 TI - A co-creation approach to selecting and adapting adolescent tobacco and air-pollution interventions and strategies for implementation in diverse countries: insights from FRESHAIR4Life. LID - 10.1186/s43058-026-01044-4 [doi] LID - 188 AB - BACKGROUND: Evidence-based interventions to reduce adolescents' exposure to tobacco and air pollution are rarely implemented in low- and middle-income countries, often because they lack contextual fit. The 'FRESHAIR4Life' project aimed to optimise implementation of contextually adapted, evidence-based interventions in Greece, Kyrgyzstan, Pakistan, Romania, and Uganda. Selecting appropriate interventions required deliberate, inclusive, and context-sensitive decision-making. This paper outlines the co-creation approach for selecting and adapting interventions, developing implementation strategies and addressing the challenges that arose. METHODS: Each country followed a four-step process. First, findings from local situational analyses were consolidated to identify barriers and facilitators across individual, community, and system levels and to map targets for change using the Theoretical Domains Framework. This was followed by a workshop with country-teams to identify key risk factors, target behaviours, relevant populations and settings, and to shortlist potential interventions from the FRESHAIR4Life palette alongside implementation strategies using option grids and ranking. A subsequent stakeholder workshop applied a Socio Technical Allocation of Resources informed approach to elicit perspectives on the interventions' value using qualitative (Conversation Cafe style discussions) and quantitative methods (ratings of need, importance, likely reach, feasibility, and local adaptations required, fixed budget allocation exercises or ranking of options). Finally, selection meetings with country teams finalised intervention choices and implementation strategies, informed by stakeholder input. RESULTS: Countries chose to target the risk factors that were considered most prevalent and the biggest threat to adolescent health in their settings. Of the four countries addressing tobacco use, Pakistan, Greece, and Romania selected 'implementation intentions (If-Then approach)' for prevention, while Kyrgyzstan selected 'very brief advice plus behavioural counselling (VBA+)' for cessation. All three countries addressing air pollution, Pakistan, Uganda and Kyrgyzstan selected social media campaigns. Key challenges included: (1) establishing a sound basis for selection decisions, which was overcome by adopting a systematic, transparent and inclusive decision process (2) ethical and practical considerations for addressing tobacco/nicotine use within school-based prevention, tackled by adapting intervention to include offer of cessation support (3) limited evidence-based interventions targeting ambient air pollution, addressed by flexibly moving beyond the palette (4) the evolving nature of implementation strategies and (5) embedding interventions into routine practice, both addressed through flexibility and adaptation. CONCLUSION: This study shows that, across diverse country contexts, defensible intervention selection depends not only on which intervention is chosen, but on how choices are made and by whom. A transparent, stakeholder-owned co-creation process, involving the target audience of adolescents, helped country teams navigate trade-offs between evidence, local burden, feasibility, fit with routine practice, and ethical obligations, while exposing important evidence gaps for individual- and community-level ambient air-pollution interventions in LMICs. CI - (c) 2026. The Author(s). FAU - Abhyankar, Purva AU - Abhyankar P AUID- ORCID: 0000-0002-0779-6588 AD - Usher Institute, University of Edinburgh, 5‒7 Little France Road, Edinburgh BioQuarter ‒ Gate 3, Edinburgh, UK. pabhyank@ed.ac.uk. FAU - Lepe, Alexander AU - Lepe A AD - Global Health Unit, Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. AD - Socio-Economic Panel, German Institute for Economic Research, Berlin, Germany. FAU - van der Schans, Jurjen AU - van der Schans J AD - Global Health Unit, Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. FAU - van den Brand, Floor A AU - van den Brand FA AD - Department of Family Medicine (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. FAU - Siddiqui, Faraz AU - Siddiqui F AD - Department of Health Sciences, University of York, York, UK. FAU - Saeed, Saima AU - Saeed S AD - Indus Hospital and Health Network, Karachi, Pakistan. FAU - Akhter, Javeria AU - Akhter J AD - Indus Hospital and Health Network, Karachi, Pakistan. FAU - Khan, Amina AU - Khan A AD - The Initiative, Islamabad, Pakistan. FAU - Kamran Baba, Mian Ali AU - Kamran Baba MA AD - The Initiative, Islamabad, Pakistan. FAU - Tsiligianni, Ioanna AU - Tsiligianni I AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Bouloukaki, Izolde AU - Bouloukaki I AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Christodoulakis, Antonios AU - Christodoulakis A AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Katagira, Winceslaus AU - Katagira W AD - College of Health Sciences, Makerere University Lung Institute, Makerere University, Kampala, Uganda. FAU - Kirenga, Bruce AU - Kirenga B AD - College of Health Sciences, Makerere University Lung Institute, Makerere University, Kampala, Uganda. FAU - Isar, Cristina AU - Isar C AD - Centrul National de Studii pentru Medicina Familiei (CNSMF RespiRO), Bucharest, Romania. FAU - Antohe, Adriana AU - Antohe A AD - Centrul National de Studii pentru Medicina Familiei (CNSMF RespiRO), Bucharest, Romania. FAU - Lupu, Anca AU - Lupu A AD - Centrul National de Studii pentru Medicina Familiei (CNSMF RespiRO), Bucharest, Romania. FAU - Neculau, Andrea AU - Neculau A AD - Universitatea Transilvania, Brasov, Romania. FAU - Sooronbaev, Talant AU - Sooronbaev T AD - Department of Pulmonology and Allergology, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov, Bishkek, Kyrgyzstan. FAU - Mirzalieva, Gulzada AU - Mirzalieva G AD - Department of Pulmonology and Allergology, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov, Bishkek, Kyrgyzstan. FAU - Taalaibekova, Aijan AU - Taalaibekova A AD - Department of Pulmonology and Allergology, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov, Bishkek, Kyrgyzstan. FAU - van der Kleij, Rianne AU - van der Kleij R AD - Leiden University Medical Center, Public Health & Primary Care, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands. FAU - Arvind, D K AU - Arvind DK AD - Centre for Speckled Computing, School of Informatics, University of Edinburgh, Edinburgh, UK. FAU - Williams, Sian AU - Williams S AD - International Primary Care Respiratory Group (IPCRG), Edinburgh, UK. FAU - Carvalho, Luis AU - Carvalho L AD - International Primary Care Respiratory Group (IPCRG), Edinburgh, UK. FAU - Pinnock, Hilary AU - Pinnock H AD - Usher Institute, University of Edinburgh, 5‒7 Little France Road, Edinburgh BioQuarter ‒ Gate 3, Edinburgh, UK. LA - eng GR - 101095461/HORIZON EUROPE European Research Council/ PT - Journal Article DEP - 20260720 PL - England TA - Implement Sci Commun JT - Implementation science communications JID - 101764360 PMC - PMC13584592 OTO - NOTNLM OT - Adaptation OT - Air pollution OT - Co-creation OT - Implementation research OT - Intervention selection OT - NCD prevention OT - Nicotine use OT - Stakeholder involvement OT - Tobacco use COIS- Declarations. Ethics approval and consent to participate: The research was conducted according to the ethical standards as outlined in the Declaration of Helsinki. Ethical approvals for all project activities were granted from the research ethics committees in all included countries. Kyrgyzstan: Ethical committee of the National Center of Cardiology and Internal Medicine named after academician capital EM, Cyrillic. Mismall pe, Cyrillicakhimov (NCCIM) (October 2023). Pakistan: National Institutes of Health, Health Research Institute, National Bioethics Committee For Research (NBC-R) (December 2023, January 2025). Greece: Ethics and Research Ethics Committee of University of Crete (February 2023). Romania: The Ethics Committee of Transilvania University of Brasov (CEU) (May 2024)Uganda: The Mulago Hospital Research and Ethics Committee (March 2024, July 2025). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/21 06:34 MHDA- 2026/07/21 06:35 PMCR- 2026/07/20 CRDT- 2026/07/21 00:07 PHST- 2025/11/06 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/21 06:35 [medline] PHST- 2026/07/21 06:34 [pubmed] PHST- 2026/07/21 00:07 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.1186/s43058-026-01044-4 [pii] AID - 1044 [pii] AID - 10.1186/s43058-026-01044-4 [doi] PST - epublish SO - Implement Sci Commun. 2026 Jul 20;7(1):188. doi: 10.1186/s43058-026-01044-4. PMID- 42477665 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261017 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 21 TI - Potassium intake assessed by dietary recall and urinary excretion in young South African adults: findings from the African-PREDICT study. LID - 10.1186/s12889-026-28605-5 [doi] LID - 2973 AB - BACKGROUND: South Africa has strong public health initiatives targeting salt reduction, yet population-level evidence and strategies regarding potassium intake remain limited. This gap is important given the role of potassium in mitigating sodium-related increases in blood pressure and cardiovascular disease risk. This study assessed potassium intake using dietary and urinary measures in young adults from the African-PREDICT study. METHODS: Potassium intake was estimated using three 24-hour dietary recalls and a single 24-hour urine collection per participant. Agreement between methods was evaluated using Bland-Altman analysis. RESULTS: Median potassium intake was 1911 mg/day from dietary assessment and 1683 mg/day from urinary analysis, both well below the recommended 3510 mg/day level, which is linked to sodium counterbalance and reduced cardiovascular risk. Over 90% of participants failed to meet the recommended intake across methods. Black participants and individuals of low socioeconomic status (SES) had substantially lower potassium intakes than their counterparts. Bland-Altman analysis demonstrated limited individual-level agreement (with a 95% limit-of-agreement span of approximately 5,600 mg/day), with dietary potassium intake marginally higher than urinary excretion (mean difference = 61 mg/day; p = 0.19), reflecting expected physiological potassium handling. In adjusted regression analyses, dietary potassium was inversely associated with diastolic blood pressure, while both urinary potassium and the sodium-to-potassium ratio showed no significant associations. CONCLUSION: Both methods show that potassium intake is low among young adults in South Africa, particularly among Black and low-SES groups, highlighting the need for population-level strategies to increase potassium consumption, particularly in vulnerable groups. The sodium-to-potassium ratio was associated with blood pressure only in the unadjusted model, whereas dietary potassium was associated with diastolic blood pressure in the adjusted model. Dietary assessment may be appropriate for population-level estimation of potassium intake, but its limited agreement with urinary potassium excretion at the individual level, particularly at higher intakes, may limit its utility for individual assessment. CI - (c) 2026. The Author(s). FAU - Shivambu, Arole AU - Shivambu A AD - Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. shivambuarole@gmail.com. AD - Centre of Excellence for Nutrition (CEN), North-West University, 11 Hoffman Street, Potchefstroom, 2531, South Africa. shivambuarole@gmail.com. FAU - Chiromba, Antony K AU - Chiromba AK AD - Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. FAU - van Zyl, Tertia AU - van Zyl T AD - Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. AD - SAMRC/NWU Extramural Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. LA - eng PT - Journal Article DEP - 20260721 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Potassium, Dietary) SB - IM MH - Humans MH - South Africa MH - Female MH - Male MH - *Potassium, Dietary/urine/administration & dosage MH - Young Adult MH - Adult MH - *Mental Recall MH - Adolescent MH - *Diet/statistics & numerical data PMC - PMC13670738 OTO - NOTNLM OT - Blood pressure OT - Dietary potassium OT - Potassium intake OT - Urinary potassium OT - Young adults COIS- Declarations. Ethics approval and consent to participate: Ethical approval of the present study and the African-PREDICT were obtained from the North-West University Health Research Ethics Committee, reference numbers NWU-00136-22-A1 and NWU-00001-12-A1. Gatekeeper permissions were obtained from the National Department, and the North-West Provincial Department of Health. All participants provided written informed consent before data collection, and the study adhered to the updated principles of the Declaration of Helsinki. Competing interests: The authors declare no competing interests. Consent to participate: Not applicable. EDAT- 2026/07/21 00:35 MHDA- 2026/10/15 07:17 PMCR- 2026/07/21 CRDT- 2026/07/20 23:58 PHST- 2026/05/08 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/15 07:17 [medline] PHST- 2026/07/21 00:35 [pubmed] PHST- 2026/07/20 23:58 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.1186/s12889-026-28605-5 [pii] AID - 28605 [pii] AID - 10.1186/s12889-026-28605-5 [doi] PST - epublish SO - BMC Public Health. 2026 Jul 21;26(1):2973. doi: 10.1186/s12889-026-28605-5. PMID- 42476326 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261016 IS - 1873-2607 (Electronic) IS - 0749-3797 (Linking) VI - 71 IP - 5 DP - 2026 Nov TI - Cross-Sectional Associations of Neighborhood Walkability With Baseline Physical Activity and Sedentary Time Among U.S. South Asian Adults in the SAHELI Study. PG - 108519 LID - S0749-3797(26)00262-X [pii] LID - 10.1016/j.amepre.2026.108519 [doi] AB - INTRODUCTION: The associations between neighborhood walkability, physical activity, and sedentary time have not been studied among U.S. South Asian adults, a group with significantly higher cardiovascular disease mortality than other race-ethnic groups. METHODS: The SAHELI study randomized South Asians from the Chicago, IL metro area (those aged 18-65 years with cardiovascular disease risk factors) to a 16-week lifestyle intervention versus control between 2018 and 2023. At baseline, total physical activity, moderate-to-vigorous physical activity, light physical activity, and sedentary time were measured by accelerometer. Neighborhood walkability measures included the Environmental Protection Agency Walkability Index and the proportion of Google Street View images in a neighborhood containing crosswalks, sidewalks, and parks. In posthoc analyses, multiple linear regressions estimated the associations between each neighborhood walkability measure and baseline total physical activity, moderate-to-vigorous physical activity, light physical activity, and sedentary time. RESULTS: Participants from SAHELI with valid accelerometer data and neighborhood walkability data were included (N=432; 59% female, 98% immigrant, 79% Indian origin). Mean +/- SD total physical activity was 9,853 +/- 5,328 steps per day; moderate-to-vigorous physical activity was 24 +/- 19 minutes per day; light physical activity was 299 +/- 95 minutes per day; and sedentary time was 564 +/- 136 minutes per day. Neighborhood walkability measures were not associated with moderate-to-vigorous physical activity. In fully adjusted models, Environmental Protection Agency Walkability Index and sidewalks were significantly associated with higher total physical activity and light physical activity and lower sedentary time, whereas crosswalks were significantly associated with total physical activity. Parks were not associated with total physical activity, light physical activity, or sedentary time. CONCLUSIONS: The Environmental Protection Agency Walkability Index and sidewalks were significantly associated with higher total physical activity and light physical activity and lower sedentary time but not with moderate-to-vigorous physical activity. Neighborhood walkability should be considered when designing cardiovascular disease prevention interventions that promote physical activity and minimize sedentary time among U.S. South Asians. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Thangada, Neela D AU - Thangada ND AD - Division of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address: neela.thangada@northwestern.edu. FAU - Lancki, Nicola AU - Lancki N AD - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. FAU - Mooney, Stephen J AU - Mooney SJ AD - Department of Epidemiology, University of Washington, Seattle, Washington. FAU - Kandula, Namratha R AU - Kandula NR AD - Division of General Internal Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. FAU - Siddique, Juned AU - Siddique J AD - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. LA - eng GR - K24 HL155897/HL/NHLBI NIH HHS/United States GR - R01 HL132978/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20260720 PL - Netherlands TA - Am J Prev Med JT - American journal of preventive medicine JID - 8704773 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Accelerometry MH - Asia, Southern/ethnology MH - Chicago MH - Cross-Sectional Studies MH - *Exercise MH - *Neighborhood Characteristics/statistics & numerical data MH - *Sedentary Behavior MH - *Walking/statistics & numerical data MH - Asian EDAT- 2026/07/21 00:35 MHDA- 2026/10/15 23:30 CRDT- 2026/07/20 19:11 PHST- 2026/03/04 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/15 23:30 [medline] PHST- 2026/07/21 00:35 [pubmed] PHST- 2026/07/20 19:11 [entrez] AID - S0749-3797(26)00262-X [pii] AID - 10.1016/j.amepre.2026.108519 [doi] PST - ppublish SO - Am J Prev Med. 2026 Nov;71(5):108519. doi: 10.1016/j.amepre.2026.108519. Epub 2026 Jul 20. PMID- 42475851 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Assessment of malnutrition in hospitalized children: Comparison of STAMP, PYMS and STRONG-Kids screening tools. PG - 618-626 LID - S0882-5963(26)00327-1 [pii] LID - 10.1016/j.pedn.2026.07.025 [doi] AB - AIM: Early identification of malnutrition risk in hospitalized children is essential for timely nutritional intervention. This study aims diagnostic performance of three pediatric malnutrition screening tools validated in Turkish: STAMP, PYMS, and STRONG-Kids. METHODS: In this cross-sectional study, 148 hospitalized children were included. Nutritional risk was evaluated using STAMP, PYMS, and STRONG-Kids screening tools. Anthropometric measurements were performed, and height-for-age, Body Mass Index (BMI)-for-age, and Middle Upper Arm Circumference (MUAC)-for-age z-scores were calculated. The sensitivity and specificity of each tool were assessed in identifying chronic and acute malnutrition. Receiver operating characteristic (ROC) curve analysis was used to assess the discriminative ability of the screening tools. RESULTS: Chronic malnutrition was identified in 12.8% of patients and acute malnutrition in 15.5%. STAMP and STRONG-Kids showed the highest sensitivity for detecting chronic malnutrition (84.2% and 84.3%), while PYMS had the highest specificity. STRONG-Kids demonstrated the greatest sensitivity for acute malnutrition and low MUAC z-scores (100.0%). ROC analysis showed that PYMS had the highest Area Under the Curve (AUC) for acute malnutrition, whereas STRONG-Kids had the highest AUC for chronic malnutrition, although all tools demonstrated limited discriminative ability for chronic malnutrition. CONCLUSION: STAMP and STRONG-Kids were more sensitive in detecting malnutrition risk, whereas PYMS showed higher specificity. Tool performance varied according to anthropometric indicators. IMPLICATIONS TO PRACTICE: In clinical practice, selecting the screening tool according to the targeted malnutrition type and available anthropometric indicators may improve early detection and allow more effective prioritization of nutritional interventions in hospitalized children. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Mutlu, Elif AU - Mutlu E AD - Ankara University, Graduate School of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkiye. Electronic address: elifmutlu@hacettepe.edu.tr. FAU - Kokturk, Seda Nur AU - Kokturk SN AD - Bayburt University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Bayburt, Turkiye. Electronic address: sedanurkokturk@bayburt.edu.tr. FAU - Ersoy Soke, Nursena AU - Ersoy Soke N AD - Ankara University, Graduate School of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkiye. FAU - Yardimci, Hulya AU - Yardimci H AD - Ankara University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkiye. Electronic address: yildirimh@ankara.edu.tr. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260720 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Child, Preschool MH - *Mass Screening/methods MH - Turkey MH - *Nutrition Assessment MH - *Child, Hospitalized MH - Sensitivity and Specificity MH - Child MH - *Child Nutrition Disorders/diagnosis/epidemiology MH - Infant MH - ROC Curve MH - Risk Assessment MH - *Malnutrition/diagnosis MH - Anthropometry MH - Nutritional Status MH - Body Mass Index OTO - NOTNLM OT - Child OT - Malnutrition OT - Nutrition assessment OT - Nutritional status COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/21 00:35 MHDA- 2026/09/07 23:34 CRDT- 2026/07/20 18:03 PHST- 2026/01/07 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/07/21 00:35 [pubmed] PHST- 2026/07/20 18:03 [entrez] AID - S0882-5963(26)00327-1 [pii] AID - 10.1016/j.pedn.2026.07.025 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:618-626. doi: 10.1016/j.pedn.2026.07.025. Epub 2026 Jul 20. PMID- 42475675 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jul 20 TI - Mobile App Use and Pregnancy Health Literacy: Cross-Sectional Study Using Bayesian Network Analysis. PG - e85403 LID - 10.2196/85403 [doi] LID - e85403 AB - BACKGROUND: Health literacy is crucial for pregnancy outcomes; yet, 15%-44% of pregnant women have low health literacy, negatively affecting maternal and fetal health. While pregnancy apps are increasingly used to support it, the psychological mechanisms through which they influence behavior remain unclear. Understanding these mechanisms is essential for designing effective interventions. Cognitive load theory (CLT) and the integrated model of cognitive-affective learning with media (ICALM) provide theoretical frameworks for understanding these digital interventions in pregnancy's emotionally intense context. OBJECTIVE: This study aimed to understand the psychological and social-cognitive pathways through which engagement with pregnancy apps may enhance health literacy and behaviors. METHODS: This cross-sectional survey study included 998 pregnant and early postpartum women aged 18-45 years from the United States and analyzed the data using Bayesian Network (BN) modeling informed by CLT and ICALM. Participants were stratified into Pregnancy+ (Royal Philips) users (n=362), other pregnancy app users (n=507), and nonapp users (n=129). We measured digital engagement, emotions, health literacy levels, support levels and sources, and health behaviors, including physical activity, nutrition, and stress management. The BN model underwent systematic refinement through bootstrap resampling (n=1000) to evaluate arc strength, followed by k-fold cross-validation (k=5) to assess model generalizability and predictive performance. RESULTS: In our study, pregnancy apps improve health literacy or behaviors, but not through direct pathways. Instead, they work through two indirect psychological pathways: (1) digital engagement related to positive emotions, which in turn is related to health literacy and stress management, and (2) digital engagement strengthened support networks, which in turn are related to health literacy. No direct pathways from digital engagement to health literacy or behaviors were retained. Pregnancy+ users demonstrated stronger adherence to these pathways compared with other app users and nonusers, by demonstrating more joyfulness (5.1 vs 4.7; P=.046), elevated support levels (4.1 vs 3.9; P=.03), and higher critical health literacy scores (8.4 vs 8.2 vs 7.7; P<.001). Pregnancy+ users also showed higher engagement frequencies (P<.001) and more frequently cited pregnancy apps as valuable information sources (78% vs 68%, P=.01) compared with users of other pregnancy apps. CONCLUSIONS: This study reveals that pregnancy apps may enhance health literacy by fostering positive emotions and strengthening support networks. This finding challenges assumptions about digital health interventions and demonstrates that apps function as psychological support systems rather than mere information sources. The findings validate CLT and ICALM within pregnancy contexts, showing that emotionally supportive apps reduce irrelevant emotional processing that consumes cognitive capacity, thereby enhancing information retention. For practice, app developers should prioritize emotional support and social connection over content volume, while health care providers should recommend apps that enhance emotional well-being. This study demonstrates BN's value for revealing complex psychological relationships in digital health contexts. CI - (c)Hanne A A Spelt, Renee A Otte, Ad J M Denissen, Shihan Wang, Erin E O'Connor, Robin Neuhaus, Lucie Duracher. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 20.07.2026. FAU - Spelt, Hanne A A AU - Spelt HAA AUID- ORCID: 0000-0002-5304-4109 AD - Research & Development, Philips Mother & Child Care and Women's Health, Eindhoven, The Netherlands. FAU - Otte, Renee A AU - Otte RA AUID- ORCID: 0000-0001-7939-6199 AD - Research & Development, Philips Mother & Child Care and Women's Health, Eindhoven, The Netherlands. FAU - Denissen, Ad J M AU - Denissen AJM AUID- ORCID: 0000-0003-4244-8850 AD - Innovation & Development and AI Solutions, Philips Data Science & AI Engineering, Eindhoven, The Netherlands. FAU - Wang, Shihan AU - Wang S AUID- ORCID: 0000-0001-5971-7522 AD - Department of Information and Computing Sciences, Utrecht University, Utrecht, The Netherlands. FAU - O'Connor, Erin E AU - O'Connor EE AUID- ORCID: 0009-0005-3361-1080 AD - Nested Institute for Families, New York, NY, United States. AD - Teaching and Learning, New York University, New York, NY, United States. FAU - Neuhaus, Robin AU - Neuhaus R AUID- ORCID: 0000-0002-6975-8712 AD - Nested Institute for Families, New York, NY, United States. AD - Teaching and Learning, New York University, New York, NY, United States. FAU - Duracher, Lucie AU - Duracher L AUID- ORCID: 0009-0001-5391-0425 AD - Research & Development, Philips Mother & Child Care and Women's Health, Eindhoven, The Netherlands. LA - eng PT - Journal Article DEP - 20260720 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Female MH - Humans MH - Pregnancy MH - *Health Literacy MH - *Mobile Applications/statistics & numerical data MH - Cross-Sectional Studies MH - Bayes Theorem MH - Adult MH - Adolescent MH - Young Adult MH - Middle Aged MH - Digital Health PMC - PMC13434253 OTO - NOTNLM OT - Bayesian networks OT - digital lifestyle interventions OT - health literacy OT - mHealth OT - mobile apps OT - pregnancy OT - probabilistic networks OT - women's health COIS- Conflicts of Interest: HAAS, RAO, AJMD, and LD are employed by Royal Philips, which also owns Pregnancy+. EDAT- 2026/07/20 18:35 MHDA- 2026/07/20 18:36 PMCR- 2026/07/20 CRDT- 2026/07/20 16:53 PHST- 2025/10/07 00:00 [received] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/07/20 18:36 [medline] PHST- 2026/07/20 18:35 [pubmed] PHST- 2026/07/20 16:53 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - v28i1e85403 [pii] AID - 10.2196/85403 [doi] PST - epublish SO - J Med Internet Res. 2026 Jul 20;28:e85403. doi: 10.2196/85403. PMID- 42475251 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260910 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jul 20 TI - Efficacy of a Mobile Health App in Promoting Breastfeeding and Young Child Feeding Practices in Pakistan: Protocol for a Randomized Controlled Trial. PG - e93181 LID - 10.2196/93181 [doi] LID - e93181 AB - BACKGROUND: In Pakistan, one-third of under-5 deaths (58/1000 live births) are attributable to the high prevalence of stunting (40%), underweight (23%), and wasting (17.7%). Given the suboptimal prevalence of exclusive breastfeeding (EBF; 48%) and the alarmingly low consumption of a minimum acceptable diet (3.6%), mitigation of early-life nutritional risk provides a critical window of opportunity for intervention. Mobile health (mHealth) provides an innovative and low-cost option to improve infant and young child feeding practices (IYCFPs) among mothers. OBJECTIVE: This study aims to assess the efficacy of a context-specific mHealth coaching app in promoting EBF and IYCFPs compared to face-to-face (F2F) counseling. METHODS: This is a prospective, parallel-arm randomized controlled trial planned at a secondary care hospital in Karachi, Pakistan. The study will enroll 300 booked singleton pregnant women in the third trimester, who plan to stay in their respective areas for at least 1 year postdelivery, are registered for child immunization at the associated Family Health Center, own smartphones with internet access, are able to read Urdu, and provide consent. Participants in the intervention arm will receive the Pehli Ghiza mHealth app along with routine standard-of-care F2F counseling. The app will deliver context-specific educational content on breastfeeding and IYCFPs through short videos and messages sent 3 times per week, tailored to the stage of pregnancy and infant age. Participants in the control arm will receive only routine F2F counseling. The standard of care will be delivered at each follow-up visit, which is scheduled at birth, at 6, 10, and 14 weeks, and at 6, 9, and 12 months of the infant's age. Data will be collected at enrollment and at each follow-up visit using structured questionnaires. Primary outcomes are EBF and the introduction of age-appropriate complementary feeding. Secondary outcomes include early initiation of breastfeeding, continued breastfeeding at 1 year, minimum dietary diversity, meal frequency, minimum acceptable diet, and child health outcomes. Analysis will follow the intention-to-treat principle to detect a 20% absolute improvement in primary outcomes between the intervention and control groups over time and to evaluate between-group differences in feeding practices. Compliance will be determined by the proportion of participants who complete the 6-month coaching program. Usability will be assessed based on features related to design, interface, content, coaching, perception, and personal benefit. RESULTS: The study was approved by the Ethics Review Committee of the Aga Khan University and the National Ethics Committee. Participant recruitment started on February 2, 2026. As of May 18, 2026, 241 participants have been recruited. Follow-ups and outcome assessments are expected to be completed by June 2027. CONCLUSIONS: If effective, the Pehli Ghiza intervention could support the integration of digital health tools into standard of care in Pakistan and similar low- and middle-income country settings. CI - (c) Rozina Nuruddin, Rehama Iqbal, Nuruddin Mohammed, Khadija Barkat Ali Vadsaria, Sidrah Nausheen, Saleem Sayani, Iqbal Azam. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Nuruddin, Rozina AU - Nuruddin R AUID- ORCID: 0000-0002-7223-352X AD - Department of Community Health Sciences, Medical College, Aga Khan University, Stadium Road, Karachi, Sindh, 74800, Pakistan, 92 21 3486 483, 92 21 3493 4294. FAU - Iqbal, Rehama AU - Iqbal R AUID- ORCID: 0000-0002-0032-3307 AD - Medical College, Aga Khan University, Karachi, Sindh, Pakistan. FAU - Mohammed, Nuruddin AU - Mohammed N AUID- ORCID: 0000-0001-8575-2946 AD - Department of Obstetrics and Gynecology, Medical College, Aga Khan University, Karachi, Sindh, Pakistan. FAU - Vadsaria, Khadija Barkat Ali AU - Vadsaria KBA AUID- ORCID: 0000-0002-6186-0704 AD - Medical College, Aga Khan University, Karachi, Sindh, Pakistan. FAU - Nausheen, Sidrah AU - Nausheen S AUID- ORCID: 0000-0002-5326-3643 AD - Department of Obstetrics and Gynecology, Medical College, Aga Khan University, Karachi, Sindh, Pakistan. FAU - Sayani, Saleem AU - Sayani S AUID- ORCID: 0000-0003-3470-9475 AD - Digital Health Resource Center, Aga Khan University, Karachi, Sindh, Pakistan. FAU - Azam, Iqbal AU - Azam I AUID- ORCID: 0000-0003-0766-4064 AD - Department of Community Health Sciences, Medical College, Aga Khan University, Karachi, Sindh, Pakistan. LA - eng SI - ClinicalTrials.gov/NCT05590351 PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260720 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Pakistan MH - *Breast Feeding/methods/statistics & numerical data MH - *Mobile Applications/standards/statistics & numerical data MH - Female MH - Infant MH - Prospective Studies MH - Randomized Controlled Trials as Topic MH - *Health Promotion/methods MH - Telemedicine MH - *Feeding Behavior MH - Infant, Newborn PMC - PMC13384044 OTO - NOTNLM OT - Infant and young child feeding practices OT - complementary feeding OT - exclusive breastfeeding OT - malnutrition OT - mobile health app COIS- Conflicts of Interest: None declared. EDAT- 2026/07/20 18:35 MHDA- 2026/07/20 18:36 PMCR- 2026/07/20 CRDT- 2026/07/20 13:13 PHST- 2026/02/09 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/07/20 18:36 [medline] PHST- 2026/07/20 18:35 [pubmed] PHST- 2026/07/20 13:13 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - v15i1e93181 [pii] AID - 93181 [pii] AID - 10.2196/93181 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jul 20;15:e93181. doi: 10.2196/93181. PMID- 42474956 OWN - NLM STAT- Publisher LR - 20260720 IS - 1573-3432 (Electronic) IS - 0162-3257 (Linking) DP - 2026 Jul 20 TI - Dropout From Exercise Interventions in Autistic Youth: A Systematic Review and Meta-analysis. LID - 10.1007/s10803-026-07447-5 [doi] AB - PURPOSE: Exercise has multiple physical and mental health benefits for autistic youth. Dropouts from randomized controlled trials (RCTs) pose a threat to the validity of the evidence, with dropout rates varying across studies. We conducted a meta-analysis to investigate the prevalence and predictors of dropout rates among autistic youth participating in exercise RCTs. METHODS: Two authors searched major electronic databases up to 04/2025. We included RCTs of exercise interventions in autistic children and adolescents that reported dropout rates. A random effects meta-analysis, calculating the dropout prevalence in exercise group and a comparative meta-analysis comparing dropout in exercise versus control groups were conducted. Meta-regressions and subgroup analyses were conducted to explore dropout moderators. RESULTS: 21 RCT's involving 25 exercise interventions (n = 565, mean age 5.1 to 12.8 years; 81.2% males) were included. The trim-and-fill-adjusted prevalence of dropout across all studies was 24.4% (95%CI = 18.1% to 32.1%). Significant differences in dropout rates were found for the type of exercise intervention (p < 0.001), intensity (p = 0.003), and overall intervention duration (p = 0.032). Dropout was similar in exercise versus control conditions (OR = 1.0, 95%CI = 0.97 to 1.0, p = 0.90, I(2) = 0%). CONCLUSIONS: Exercise is well tolerated by autistic children and m-adolescents and drop out in RCT's is comparable to control conditions. Thus, exercise is a feasible treatment and dropout rates decrease when the intervention is aerobic exercise, with either low or high intensity and when total intervention duration is shorter. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Van Damme, Tine AU - Van Damme T AUID- ORCID: 0000-0002-8197-6704 AD - Department of Rehabilitation Sciences, KU Leuven, Herestraat 49 box 1510, Leuven, 3000, Belgium. Tine.vandamme@kuleuven.be. AD - University Psychiatric Center KU Leuven, Leuven, Belgium. Tine.vandamme@kuleuven.be. FAU - Zwahlen, Isabel AU - Zwahlen I AUID- ORCID: 0009-0001-0865-7168 AD - Department of Rehabilitation Sciences, KU Leuven, Herestraat 49 box 1510, Leuven, 3000, Belgium. FAU - de Oliveira, Jenifer AU - de Oliveira J AUID- ORCID: 0000-0001-8616-6594 AD - Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, Brazil. FAU - Meers, Esther AU - Meers E AUID- ORCID: 0009-0004-0626-6317 AD - Department of Rehabilitation Sciences, KU Leuven, Herestraat 49 box 1510, Leuven, 3000, Belgium. FAU - Schuch, Felipe Barreto AU - Schuch FB AUID- ORCID: 0000-0002-5190-4515 AD - Food and Mood Centre, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia. AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, Australia. AD - Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, Brazil. AD - Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Providencia, Chile. FAU - Vancampfort, Davy AU - Vancampfort D AUID- ORCID: 0000-0002-4592-8625 AD - Department of Rehabilitation Sciences, KU Leuven, Herestraat 49 box 1510, Leuven, 3000, Belgium. AD - University Psychiatric Center KU Leuven, Leuven, Belgium. AD - Leuven Brain Institute, Leuven, Belgium. LA - eng PT - Journal Article DEP - 20260720 PL - United States TA - J Autism Dev Disord JT - Journal of autism and developmental disorders JID - 7904301 SB - IM OTO - NOTNLM OT - Autism OT - Dropout, exercise OT - Physical activity COIS- Declarations. Conflict of interest: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/20 12:40 MHDA- 2026/07/20 12:40 CRDT- 2026/07/20 11:19 PHST- 2025/10/09 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/20 12:40 [medline] PHST- 2026/07/20 12:40 [pubmed] PHST- 2026/07/20 11:19 [entrez] AID - 10.1007/s10803-026-07447-5 [pii] AID - 10.1007/s10803-026-07447-5 [doi] PST - aheadofprint SO - J Autism Dev Disord. 2026 Jul 20. doi: 10.1007/s10803-026-07447-5. PMID- 42474951 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260913 IS - 1708-0428 (Electronic) IS - 0960-8923 (Print) IS - 0960-8923 (Linking) VI - 36 IP - 9 DP - 2026 Sep TI - From Approval to Evidence: Device Regulation, Long-Term Outcomes, and Conflicts of Interest in Metabolic Bariatric Surgery. PG - 4983-4990 LID - 10.1007/s11695-026-08871-3 [doi] AB - BACKGROUND: Device-based innovation in metabolic bariatric surgery (MBS) has proliferated under evidentiary standards that differ substantially from those for pharmaceuticals. This review examines the lifecycle of MBS devices, from regulatory approval to long-term outcomes. METHODS: We conducted a structured literature search of PubMed/MEDLINE, Embase, and Scopus for English-language publications from January 1990 through May 2026, supplemented by regulatory database searches (FDA, EUDAMED) updated to manuscript submission. Five device categories representing distinct regulatory pathways were selected a priori: adjustable gastric bands (LAGB), implantable gastric stimulation (IGS) and vagal blockade (VBLOC), endoluminal liners (EndoBarrier), and gastric clips (BariClip). Intragastric balloons were excluded as temporary, non-implanted devices with different regulatory and safety profiles. This is a narrative review that used systematic search methods for transparency; it does not claim to be a systematic review or meta-analysis. RESULTS: The LAGB received FDA approval in 2001 based on 3-year data showing 36.2% excess weight loss (EWL), despite an advisory panel voting 6 - 4 that 2-year data were inadequate. Ten-year follow-up from the Teen-LABS study (2025) demonstrated that, among adolescents with retained bands, median BMI was 51.1, a 9.2% increase from baseline in this adolescent cohort. Implantable gastric stimulation failed to show benefit in the sham-controlled SHAPE trial (11.8% vs. 11.7% EWL, p = 0.717). Vagal blockade (VBLOC) showed equivocal results in the ReCharge trial (26.1% vs. 16.9% EWL, missing its prespecified margin) yet received FDA approval in 2015 via the Humanitarian Device Exemption (HDE #H150003). The EndoBarrier received CE marking in 2009 and was widely adopted before being withdrawn; a subsequent rigorous sham-controlled trial (ENDO, 2025) confirmed efficacy but revealed a 3.3% hepatic abscess rate. The BariClip, lacking FDA approval and an active MDR CE mark (EUDAMED search performed April 15, 2026, found no active certificate), has been studied only in small single-center series with short-term follow-up (6-24 months). CONCLUSIONS: The history of device innovation in MBS reveals a recurring pattern: regulatory approval or market entry based on limited evidence, followed by gradual recognition of limited efficacy and device-specific complications. As noted in a companion systematic review, these failures are not limited to devices but reflect a broader systemic challenge. Structured oversight, including prospective registration, sham-controlled trials where feasible, post-market registries, and long-term follow-up requirements, is essential to protect patients and preserve the credibility of the field. CI - (c) 2026. The Author(s). FAU - Papadia, Francesco Saverio AU - Papadia FS AUID- ORCID: 0000-0002-6610-4094 AD - University of Genoa, Genoa, Italy. francesco.papadia@unige.it. AD - Ospedale Policlinico San Martino, Genoa, Italy. francesco.papadia@unige.it. LA - eng PT - Journal Article PT - Review DEP - 20260720 PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 SB - IM MH - Humans MH - *Bariatric Surgery/instrumentation MH - *Device Approval MH - *Conflict of Interest MH - *Obesity, Morbid/surgery MH - United States MH - Treatment Outcome PMC - PMC13562263 OTO - NOTNLM OT - Bariatric surgery OT - Conflict of interest OT - Device regulation OT - Duodenal-jejunal bypass liner OT - Gastric band OT - Gastric clip OT - Gastric electrical stimulation OT - Medical devices OT - Vagal blockade COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/20 12:40 MHDA- 2026/09/10 17:42 PMCR- 2026/07/20 CRDT- 2026/07/20 11:19 PHST- 2026/05/18 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/06/09 00:00 [revised] PHST- 2026/09/10 17:42 [medline] PHST- 2026/07/20 12:40 [pubmed] PHST- 2026/07/20 11:19 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.1007/s11695-026-08871-3 [pii] AID - 8871 [pii] AID - 10.1007/s11695-026-08871-3 [doi] PST - ppublish SO - Obes Surg. 2026 Sep;36(9):4983-4990. doi: 10.1007/s11695-026-08871-3. Epub 2026 Jul 20. PMID- 42474821 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260922 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 20 TI - Can slow and (un)steady still win the race? A narrative review of developmental gait characteristics and clinical implications in children born preterm. LID - 10.1007/s00431-026-07252-3 [doi] LID - 589 AB - Independent walking is more than a developmental milestone, as it reflects the integration of neuromuscular maturation, postural control, and sensorimotor coordination. In children born preterm, both the timing and the characteristics of independent walking may differ from those observed in term-born peers. This narrative review synthesizes current evidence on independent walking acquisition and gait features in preterm-born children throughout different stages of life, from toddler to school age, and discusses the clinical implications of quantitative gait assessment, with a focus on innovative wearable technologies, during neurodevelopmental follow-up. Preterm birth is consistently associated with a 1-2-month delay in independent walking onset compared with term-born peers, even after correction for gestational age (GA), with greater delays reported in infants born at lower GA or with very low birth weight (BW). Beyond milestone attainment, both qualitative and quantitative studies describe less mature gait patterns during early walking and the preschool years, including shorter step length, wider base of support, prolonged double-support phase, increased temporal variability, and reduced gait complexity. These characteristics likely reflect compensatory strategies related to immature postural control and sensorimotor organization. Although many spatiotemporal parameters improve with age and walking experience, subtle differences may persist into school age, particularly under more demanding conditions such as dual-task walking. However, currently available studies on preterm gait are quite heterogeneous in terms of GA, BW, and/or individual walking experience of included individuals and gait analysis methods employed. Furthermore, evidence regarding gait characteristics in preschool and school-aged preterm children is still relatively scarce, thus hampering a deeper understanding of preterm-born children's gait development after the toddler stage. CONCLUSION: Instrumented gait analysis systems and wearable technologies, including inertial measurement units, enable objective and ecologically valid assessment of gait performance. Quantitative gait parameters have shown associations with standardised gross motor scores and may provide additional information beyond milestone history alone. Incorporating structured quantitative gait assessment into longitudinal follow-up programmes could support more detailed monitoring of motor development and inform individualised rehabilitation planning in children born preterm. WHAT IS KNOWN: * Children born preterm generally achieve independent walking later than term-born peers and may show immature gait features, particularly during the first years of life. * Most available evidence is heterogeneous and focuses mainly on walking onset or early gait, with limited data extending into preschool and school age. WHAT IS NEW: * This review integrates evidence on gait development from the fi rst independent steps to school age, identifying persistent abnormalities mainly in children born at lower gestational ages, with lower birth weight, or under demanding walking conditions. * It highlights the potential role of quantitative gait analysis and wearable inertial sensors as complementary tools for longitudinal neurodevelopmental follow-up and individualized rehabilitation planning. CI - (c) 2026. The Author(s). FAU - Ruscelli, Martina AU - Ruscelli M AD - Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. FAU - Fetta, Anna AU - Fetta A AUID- ORCID: 0000-0003-0175-6486 AD - Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. anna.fetta2@unibo.it. AD - UOC Neuropsichiatria Dell'eta Pediatrica, IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Bologna, Italy. anna.fetta2@unibo.it. FAU - Benvenuti, Ettore AU - Benvenuti E AD - Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. FAU - Bisi, Maria Cristina AU - Bisi MC AD - Department of Electrical, Electronic, and Information Engineering "Guglielmo Marconi", University of Bologna, Bologna, Italy. FAU - Stagni, Rita AU - Stagni R AD - Department of Electrical, Electronic, and Information Engineering "Guglielmo Marconi", University of Bologna, Bologna, Italy. FAU - Zardi, Elena AU - Zardi E AD - Physical Medicine and Rehabilitation Unit, IRCCS AOU Bologna, Bologna, Italy. FAU - Sansavini, Alessandra AU - Sansavini A AD - Department of Psychology "Renzo Canestrari", University of Bologna, Bologna, Italy. FAU - Corvaglia, Luigi AU - Corvaglia L AD - Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. AD - Neonatal Intensive Care Unit, IRCCS AOU Bologna, Bologna, Italy. FAU - Cordelli, Duccio Maria AU - Cordelli DM AD - Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. AD - UOC Neuropsichiatria Dell'eta Pediatrica, IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Bologna, Italy. FAU - Aceti, Arianna AU - Aceti A AD - Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. AD - Neonatal Intensive Care Unit, IRCCS AOU Bologna, Bologna, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260720 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Gait/physiology MH - Child, Preschool MH - Infant, Newborn MH - *Child Development/physiology MH - *Infant, Premature/growth & development MH - Child MH - Infant MH - *Walking/physiology MH - Gestational Age PMC - PMC13385000 OTO - NOTNLM OT - Gait assessment OT - Independent walking OT - Inertial measurement units OT - Neurodevelopmental follow-up OT - Prematurity COIS- Declarations. Competing Interests: The authors declare no competing interests. EDAT- 2026/07/20 12:40 MHDA- 2026/07/20 12:41 PMCR- 2026/07/20 CRDT- 2026/07/20 11:16 PHST- 2026/04/01 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/20 12:41 [medline] PHST- 2026/07/20 12:40 [pubmed] PHST- 2026/07/20 11:16 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.1007/s00431-026-07252-3 [pii] AID - 7252 [pii] AID - 10.1007/s00431-026-07252-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 20;185(8):589. doi: 10.1007/s00431-026-07252-3. PMID- 42474673 OWN - NLM STAT- Publisher LR - 20260720 IS - 1573-2584 (Electronic) IS - 0301-1623 (Linking) DP - 2026 Jul 20 TI - Clinical outcomes of thulium fiber laser versus holmium:YAG laser during pediatric retrograde intrarenal surgery: a multicenter cohort study. LID - 10.1007/s11255-026-05292-0 [doi] AB - OBJECTIVE: The thulium fiber laser (TFL) is a new-generation laser technology that has been increasingly used in endourology in recent years. However, data on the use of TFL in the treatment of pediatric kidney stones are limited. The aim of this study was to compare the efficacy and safety of thulium fiber laser (TFL) and Holmium: Yttrium Aluminum Garnet (Ho:YAG) laser in children undergoing retrograde intrarenal surgery (RIRS) for a solitary renal stone measuring 10-20 mm. MATERIALS AND METHODS: Pediatric patients (< 18 years) with a solitary renal stone measuring 10-20 mm who underwent RIRS at two tertiary referral centers between January 2020 and March 2026 were retrospectively reviewed. Patients were divided into two groups based on the laser technology used: Ho:YAG and TFL. Ho:YAG lithotripsy was predominantly performed using fragmentation strategy, whereas TFL was mainly used in dusting mode. The primary endpoint was the stone-free rate (SFR), as assessed by ultrasound at the third postoperative month. Secondary endpoints included operative time, fluoroscopy time, intraoperative stone retropulsion, the need for reintervention, length of hospital stay, and complications according to the Clavien-Dindo classification. RESULTS: A total of 74 patients were included in the study. Forty-eight patients were treated with Ho:YAG, and 26 with TFL. The groups were comparable in terms of age, sex, body mass index, stone size, stone density, and stone location. Operative time was significantly shorter in the TFL group than in the Ho:YAG group (64.0 +/- 28.35 vs. 80.0 +/- 30.17 min, p = 0.028). Intraoperative stone retropulsion occurred significantly less frequently in the TFL group (11.5% vs. 35.4%, p = 0.031). The 3-month stone-free rate was 92.3% in the TFL group and 85.4% in the Ho:YAG group, with no significant difference between the groups (p = 0.486). No significant differences were found between the groups in terms of fluoroscopy time, reintervention rate, and length of hospital stay. Complication rates were similar, and no Clavien-Dindo grade IV or V complications were observed in either group. CONCLUSION: These findings suggest that TFL may represent a safe and effective alternative to the Ho:YAG laser in pediatric RIRS. However, further prospective multicenter studies using standardized laser settings are warranted to validate these findings. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature B.V. FAU - Ozcift, Burak AU - Ozcift B AUID- ORCID: 0000-0001-8474-2308 AD - Department of Pediatric Urology, Health Sciences University, Izmir Dr. Behcet Uz Child Diseases and Surgery Training and Research Hospital, Ismet Kaptan Mh. Sezer Dogan Sok. No: 11 Konak, Izmir, Turkey. burakozcift@gmail.com. FAU - Micoogullari, Uygar AU - Micoogullari U AUID- ORCID: 0000-0003-4729-6104 AD - Department of Urology, Izmir Can Hospital, Izmir, Turkey. LA - eng PT - Journal Article DEP - 20260720 PL - Netherlands TA - Int Urol Nephrol JT - International urology and nephrology JID - 0262521 SB - IM OTO - NOTNLM OT - Flexible ureteroscopy OT - Holmium:YAG laser OT - Pediatric urolithiasis OT - Renal stone OT - Retrograde intrarenal surgery OT - Thulium fiber laser COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Health Sciences University Tepecik Training and Research Hospital (No. 2022/12-27). EDAT- 2026/07/20 12:40 MHDA- 2026/07/20 12:40 CRDT- 2026/07/20 11:08 PHST- 2026/06/27 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/20 12:40 [medline] PHST- 2026/07/20 12:40 [pubmed] PHST- 2026/07/20 11:08 [entrez] AID - 10.1007/s11255-026-05292-0 [pii] AID - 10.1007/s11255-026-05292-0 [doi] PST - aheadofprint SO - Int Urol Nephrol. 2026 Jul 20. doi: 10.1007/s11255-026-05292-0. PMID- 42474402 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260923 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 10 DP - 2026 Oct TI - Understanding Postpartum Mothers' Perspectives of Chrononutrition Approaches: A Qualitative Study. PG - 156393 LID - S2212-2672(26)00108-5 [pii] LID - 10.1016/j.jand.2026.156393 [doi] AB - BACKGROUND: Postpartum weight retention (PPWR) is common and associated with poor health outcomes. Traditional weight management approaches have limited success postpartum. Due to infant-related sleep disruptions, late-night eating may be more common postpartum and contribute to PPWR. Chrononutrition interventions, which align energy intake with circadian rhythms in metabolism, demonstrate promise for weight loss in nonpostpartum populations and offer a novel approach to preventing PPWR. However, no studies have explored whether chrononutrition approaches may be acceptable postpartum, which is needed to inform which approaches may warrant subsequent testing. OBJECTIVE: To characterize perceived determinants of eating timing and understand the feasibility of following various chrononutrition approaches among postpartum mothers. DESIGN: A qualitative descriptive study using semistructured interviews to query participants about the following chrononutrition approaches, which they also ranked from most to least preferred: bedtime stopping rule (no energy intake within a certain number of hours of bedtime); king's breakfast, pauper's dinner (distributing kilocalories so intake is highest at breakfast and lowest at dinner), and time-restricted eating (shortening the daily eating window to /=84% explained variance) and strong correlation with reference techniques. Pasteurization significantly reduced alpha-lactalbumin (24%) and lactoferrin (14%), while casein and total protein declined slightly (3%). Protein levels decreased notably during early lactation, then stabilized. In the cohort of the present study, no statistically significant differences in protein content were observed between preterm and term milk. EC-QCL spectroscopy also differentiated raw and pasteurized DHM. These results support EC-QCL as a reliable tool for clinical use and quality control, with implications for improving processing methods to preserve the nutritional and immunological integrity of DHM. CI - (c) 2026 Published by Elsevier B.V. FAU - Ten-Domenech, Isabel AU - Ten-Domenech I AD - Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS- SAMID) (RD24/0013/0014), Neonatal Research Group, Health Research Institute La Fe (IIS La Fe), Avda Fernando Abril Martorell 106, Valencia, 46026, Spain. AD - Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, Burjassot, 46100, Spain. AD - Servicio de Analisis de Vesiculas Extracelulares (SAVE), Health Research Institute La Fe (IIS La Fe), Avda Fernando Abril Martorell 106, Valencia, 46026, Spain. FAU - Vijayakumar, Shilpa AU - Vijayakumar S AD - Institute of Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt 9/164-UPA, Vienna, 1060, Austria. AD - Christian Doppler Laboratory for Advanced Mid-Infrared Laser Spectroscopy in (Bio-)process Analytics, TU Wien, Vienna, 1060, Austria. FAU - Schwaighofer, Andreas AU - Schwaighofer A AD - Institute of Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt 9/164-UPA, Vienna, 1060, Austria. FAU - Ramer, Georg AU - Ramer G AD - Institute of Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt 9/164-UPA, Vienna, 1060, Austria. AD - Christian Doppler Laboratory for Advanced Mid-Infrared Laser Spectroscopy in (Bio-)process Analytics, TU Wien, Vienna, 1060, Austria. FAU - Van den Oever, Sabrina P AU - Van den Oever SP AD - Department of Biotechnology and Food Sciences, Institute of Food Science, BOKU University, Muthgasse 18, Vienna, 1190, Austria. FAU - Moreno-Gimenez, Alba AU - Moreno-Gimenez A AD - Neonatal Research Group, Health Research Institute La Fe (IIS La Fe), Avda Fernando Abril Martorell 106, Valencia, 46026, Spain. FAU - Parra-Llorca, Anna AU - Parra-Llorca A AD - Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS- SAMID) (RD24/0013/0014), Neonatal Research Group, Health Research Institute La Fe (IIS La Fe), Avda Fernando Abril Martorell 106, Valencia, 46026, Spain. AD - Division of Neonatology, University & Polytechnic Hospital La Fe, Avda Fernando Abril Martorell 106, Valencia, 46026, Spain. FAU - Vaya, Maria J AU - Vaya MJ AD - Blood Transfusion Center from the Valencian Community, Av. del Cid, 65-acc, Valencia, 46014, Spain. FAU - Gormaz, Maria AU - Gormaz M AD - Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS- SAMID) (RD24/0013/0014), Neonatal Research Group, Health Research Institute La Fe (IIS La Fe), Avda Fernando Abril Martorell 106, Valencia, 46026, Spain. AD - Division of Neonatology, University & Polytechnic Hospital La Fe, Avda Fernando Abril Martorell 106, Valencia, 46026, Spain. FAU - Mayer, Helmut K AU - Mayer HK AD - Department of Biotechnology and Food Sciences, Institute of Food Science, BOKU University, Muthgasse 18, Vienna, 1190, Austria. FAU - Quintas, Guillermo AU - Quintas G AD - Health and Biomedicine, Leitat Technological Center, Carrer de la Innovacio, 2, Terrassa, 08225, Spain. FAU - Kuligowski, Julia AU - Kuligowski J AD - Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS- SAMID) (RD24/0013/0014), Neonatal Research Group, Health Research Institute La Fe (IIS La Fe), Avda Fernando Abril Martorell 106, Valencia, 46026, Spain. AD - Servicio de Analisis de Vesiculas Extracelulares (SAVE), Health Research Institute La Fe (IIS La Fe), Avda Fernando Abril Martorell 106, Valencia, 46026, Spain. FAU - Lendl, Bernhard AU - Lendl B AD - Institute of Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt 9/164-UPA, Vienna, 1060, Austria. LA - eng PT - Journal Article DEP - 20260707 PL - Netherlands TA - Curr Res Food Sci JT - Current research in food science JID - 101771059 PMC - PMC13380451 OTO - NOTNLM OT - Alpha-lactalbumin OT - Casein OT - External cavity quantum cascade laser (EC-QCL) OT - Infrared spectroscopy OT - Lactoferrin OT - Pasteurization OT - Protein COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/19 06:41 MHDA- 2026/07/19 06:42 PMCR- 2026/07/07 CRDT- 2026/07/19 03:58 PHST- 2026/01/12 00:00 [received] PHST- 2026/06/21 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/19 06:42 [medline] PHST- 2026/07/19 06:41 [pubmed] PHST- 2026/07/19 03:58 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - S2665-9271(26)00192-9 [pii] AID - 101492 [pii] AID - 10.1016/j.crfs.2026.101492 [doi] PST - epublish SO - Curr Res Food Sci. 2026 Jul 7;13:101492. doi: 10.1016/j.crfs.2026.101492. eCollection 2026. PMID- 42471810 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260719 LR - 20260813 IS - 2590-1613 (Electronic) IS - 2590-1613 (Linking) VI - 31 DP - 2026 Sep TI - A logistic regression model for predicting postoperative recurrence of cellular uterine leiomyoma. PG - 100469 LID - 10.1016/j.eurox.2026.100469 [doi] LID - 100469 AB - OBJECTIVE: The risk factors for the postoperative recurrence of cellular uterine leiomyoma (CUL) remain unclear.This study aimed to identify independent risk factors for recurrence and to develop a predictive model based on clinical characteristics to assess individual recurrence risk. METHODS: This retrospective study included patients who underwent uterine myomectomy at Fujian Maternal and Child Health Hospital between January 1, 2012, and December 31, 2021, and were pathologically confirmed to have CUL. The 176 patients who met the inclusion criteria were grouped into two categories: the recurrence group (76 cases) and the non-recurrence group (100 cases). Univariate and multivariate logistic regression analyses were performed to identify the risk factors for postoperative recurrence, and a nomogram prediction model was built. RESULTS: Patients were followed for a median of 4 years (range: 1.75-7.5 years), during which 76 patients (43.2%) experienced recurrence.Tumor number >/= 2, body mass index (BMI) >/= 24.0 kg/m(2), and concurrent endometriosis were significantly associated with recurrence (p < 0.05). Three factors were recognized as independent predictors of recurrence through multivariate logistic regression. The area under the receiver operating characteristic curve of the constructed nomogram model was 0.791 (95% confidence interval: 0.724-0.858). Decision curve analysis showed a good clinical net benefit, and calibration curves showed a high consistency between the predicted and actual recurrence probabilities. CONCLUSION: Patients with CUL who have risk factors require close monitoring for postoperative recurrence. The developed nomogram model exhibited good predictive performance, thereby offering a reference for treatment choice and recurrence prediction. CI - (c) 2026 Published by Elsevier B.V. FAU - Zhong, Yanling AU - Zhong Y AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18, Daoshan Road, Gulou District, Fuzhou 350001, China. FAU - Xu, Mu AU - Xu M AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18, Daoshan Road, Gulou District, Fuzhou 350001, China. FAU - Cai, Liangzhi AU - Cai L AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18, Daoshan Road, Gulou District, Fuzhou 350001, China. LA - eng PT - Journal Article DEP - 20260617 PL - Netherlands TA - Eur J Obstet Gynecol Reprod Biol X JT - European journal of obstetrics & gynecology and reproductive biology: X JID - 101750520 PMC - PMC13380213 OTO - NOTNLM OT - Cellular uterine leiomyoma OT - Myomectomy OT - Postoperative recurrence OT - Predictive model COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/19 06:41 MHDA- 2026/07/19 06:42 PMCR- 2026/06/17 CRDT- 2026/07/19 03:53 PHST- 2025/09/02 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/19 06:42 [medline] PHST- 2026/07/19 06:41 [pubmed] PHST- 2026/07/19 03:53 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - S2590-1613(26)00026-8 [pii] AID - 100469 [pii] AID - 10.1016/j.eurox.2026.100469 [doi] PST - epublish SO - Eur J Obstet Gynecol Reprod Biol X. 2026 Jun 17;31:100469. doi: 10.1016/j.eurox.2026.100469. eCollection 2026 Sep. PMID- 42471634 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261017 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 18 TI - Associations of Haller index and manual depth measurement with clinical findings and pulmonary function in children with pectus excavatum: a retrospective cross-sectional study. LID - 10.1186/s12887-026-07308-1 [doi] LID - 1003 AB - BACKGROUND: Pectus excavatum (PE) is the most common congenital chest wall deformity. Its severity is usually assessed by chest computed tomography (CT) based indices such as the Haller index (HI) and correction index (CI). However, evidence supporting non-imaging anthropometric methods is limited. Manual depth measurement (MDM) is a simple, noninvasive bedside method that may offer clinical value. METHODS: This retrospective cross-sectional study included children diagnosed with pectus excavatum and followed at a tertiary center between 2017 and 2024. Demographics, pulmonary function tests (PFTs), symptoms, comorbidities, and echocardiographic data were analyzed. HI and CI were measured using chest CT scans. MDM values recorded during follow-up were retrieved from physical exam notes. RESULTS: A total of 127 patients were included, with a median age of 7.25 years (IQR, 7.05). Median HI was 2.70 (IQR, 0.56), median MDM was 2.00 cm (IQR, 1.35), and median CI was 16% (IQR, 6.7). MDM was significantly correlated with HI (p = 0.012). ROC analysis showed that MDM moderately but significantly discriminated severe deformity defined as HI> 2.5, with an optimal cut-off value of 1.75 cm. Respiratory symptoms and comorbidities were present in 39.4% and 38.6% of patients, respectively. Pulmonary function impairment was observed in 19% of patients, predominantly with a restrictive pattern. HI> 2.5 was associated with reduced forced vital capacity (FVC) and total lung capacity (TLC), whereas the association between MDM> 1.75 cm and TLC <80% weakened after adjustment for age. CONCLUSION: MDM is a practical bedside measurement that correlates with HI and involves no radiation exposure. An MDM threshold of 1.75 cm was associated with HI> 2.5 in the CT-evaluated subgroup and may support conservative follow-up when interpreted together with clinical and functional findings. This threshold should be considered exploratory and requires prospective validation. CI - (c) 2026. The Author(s). FAU - Yoruk, Begum AU - Yoruk B AUID- ORCID: 0000-0001-6599-9802 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Caglar, Yasemin Mocan AU - Caglar YM AUID- ORCID: 0000-0002-9609-478X AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Ulgen, Ozge AU - Ulgen O AUID- ORCID: 0000-0002-9271-5446 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Oksay, Sinem Can AU - Oksay SC AUID- ORCID: 0000-0001-9801-3181 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Bilgin, Gulay AU - Bilgin G AUID- ORCID: 0000-0001-6207-3748 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Tortop, Deniz Mavi AU - Tortop DM AUID- ORCID: 0000-0002-9134-5658 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Girit, Saniye AU - Girit S AUID- ORCID: 0000-0001-7556-6568 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. saniye.girit@medeniyet.edu.tr. LA - eng PT - Journal Article DEP - 20260718 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Funnel Chest/physiopathology/diagnosis/diagnostic imaging MH - Cross-Sectional Studies MH - Retrospective Studies MH - Child MH - Female MH - Male MH - Respiratory Function Tests MH - Tomography, X-Ray Computed MH - Severity of Illness Index MH - Child, Preschool MH - Adolescent MH - *Anthropometry/methods PMC - PMC13670605 OTO - NOTNLM OT - anthropometric measurement OT - manual depth measurement OT - pectus excavatum OT - pediatric OT - pulmonary function test COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of Kartal Kosuyolu Hospital on January 7, 2025 (Approval Number: 2025/01/1005). The study was conducted in accordance with the principles of the Declaration of Helsinki. Due to the retrospective design of the study, the requirement for informed consent, including parental or legal guardian consent for participants younger than 16 years of age, was waived by the ethics committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/19 04:00 MHDA- 2026/10/15 07:17 PMCR- 2026/07/18 CRDT- 2026/07/18 23:25 PHST- 2026/05/09 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/10/15 07:17 [medline] PHST- 2026/07/19 04:00 [pubmed] PHST- 2026/07/18 23:25 [entrez] PHST- 2026/07/18 00:00 [pmc-release] AID - 10.1186/s12887-026-07308-1 [pii] AID - 7308 [pii] AID - 10.1186/s12887-026-07308-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 18;26(1):1003. doi: 10.1186/s12887-026-07308-1. PMID- 42471599 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261015 IS - 1471-2377 (Electronic) IS - 1471-2377 (Linking) VI - 26 IP - 1 DP - 2026 Jul 18 TI - Genotype-phenotype relationship in a cohort of 131 Chinese patients with myotonic dystrophy type 1. LID - 10.1186/s12883-026-05180-1 [doi] LID - 647 AB - INTRODUCTION: Myotonic dystrophy type 1 (DM1) is an autosomal dominant dynamic mutation disorder characterized by myotonia and muscle weakness. The genotype-phenotype relationship has not been clearly defined in Chinese patients. METHODS: The clinical and genetic characteristics of 131 patients from 105 pedigrees were retrospectively analyzed. Triplet-primed Polymerase Chain Reaction (PCR) and Flanking PCR were performed to analyze the CTG repeats in DMPK gene. RESULTS: Among 131 DM1 patients, 64.9% were male, indicating a higher male admission rate, possibly due to limited diagnostic awareness in China. Notably, 11.5% of patients were not initially diagnosed in Neurology Department. The linear negative correlation between CTG repeat number and age of onset was no longer valid when CTG repeats exceeded approximately 400. Forced vital capacity (FVC) was negatively correlated with CTG repeat number, while no significant correlations were found with the Modified Scheltens score, creatine kinase, troponin T, lipid profile, glycosylated hemoglobin, fasting glucose, or BMI. In 16 families studied, CTG repeats expanded in 13 and contracted in 2. White matter lesions were detected in 97.9% of patients, predominantly in the supratentorial region, bilaterally affecting the frontal lobes, temporal poles, and deep white matter. CONCLUSION: Our results provide insightful information on the clinical and genetic characteristics of the largest Chinese cohort of DM1 patients to date and clarify genotype-phenotype relationship. CI - (c) 2026. The Author(s). FAU - Pan, Li-Ying AU - Pan LY AD - Department of Medical Genetics and Center for Rare Diseases, Department of Neurology in Second Affiliated Hospital, Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation, Zhejiang University School of Medicine, Hangzhou, China. AD - Department of Neurology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China. FAU - Li, Jin-Wen AU - Li JW AD - Department of Medical Genetics and Center for Rare Diseases, Department of Neurology in Second Affiliated Hospital, Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation, Zhejiang University School of Medicine, Hangzhou, China. FAU - Yu, Hao AU - Yu H AD - Department of Medical Genetics and Center for Rare Diseases, Department of Neurology in Second Affiliated Hospital, Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation, Zhejiang University School of Medicine, Hangzhou, China. FAU - Dong, Hai-Lin AU - Dong HL AD - Department of Medical Genetics and Center for Rare Diseases, Department of Neurology in Second Affiliated Hospital, Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation, Zhejiang University School of Medicine, Hangzhou, China. FAU - Zou, Sheng-Mei AU - Zou SM AD - Department of Medical Genetics and Center for Rare Diseases, Department of Neurology in Second Affiliated Hospital, Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation, Zhejiang University School of Medicine, Hangzhou, China. FAU - Wu, Zhi-Ying AU - Wu ZY AUID- ORCID: 0000-0003-2106-572X AD - Department of Medical Genetics and Center for Rare Diseases, Department of Neurology in Second Affiliated Hospital, Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation, Zhejiang University School of Medicine, Hangzhou, China. zhiyingwu@zju.edu.cn. FAU - Liu, Gong-Lu AU - Liu GL AUID- ORCID: 0000-0002-4047-5516 AD - Department of Medical Genetics and Center for Rare Diseases, Department of Neurology in Second Affiliated Hospital, Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation, Zhejiang University School of Medicine, Hangzhou, China. gongluliu@zju.edu.cn. LA - eng GR - 822300620/National Natural Science Foundation of China/ GR - LY19H090023/Natural Science Foundation of Zhejiang Province/ PT - Journal Article DEP - 20260718 PL - England TA - BMC Neurol JT - BMC neurology JID - 100968555 RN - 0 (DMPK protein, human) RN - EC 2.7.11.1 (Myotonin-Protein Kinase) RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - China MH - Cohort Studies MH - Genetic Association Studies MH - Genotype MH - *Myotonic Dystrophy/genetics/physiopathology/pathology MH - *Myotonin-Protein Kinase/genetics MH - Phenotype MH - Retrospective Studies MH - Trinucleotide Repeat Expansion/genetics MH - East Asian People/genetics PMC - PMC13660078 OTO - NOTNLM OT - Chinese OT - Genotype OT - Myotonic dystrophy OT - Phenotype OT - White matter hyperintensities COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the Second Affiliated Hospital, Zhejiang University School of Medicine. It was conducted in accordance with the Declaration of Helsinki, and written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/19 04:00 MHDA- 2026/10/14 06:31 PMCR- 2026/07/18 CRDT- 2026/07/18 23:24 PHST- 2025/08/28 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/14 06:31 [medline] PHST- 2026/07/19 04:00 [pubmed] PHST- 2026/07/18 23:24 [entrez] PHST- 2026/07/18 00:00 [pmc-release] AID - 10.1186/s12883-026-05180-1 [pii] AID - 5180 [pii] AID - 10.1186/s12883-026-05180-1 [doi] PST - epublish SO - BMC Neurol. 2026 Jul 18;26(1):647. doi: 10.1186/s12883-026-05180-1. PMID- 42470661 OWN - NLM STAT- MEDLINE DCOM- 20260718 LR - 20260826 IS - 1532-7078 (Electronic) IS - 1525-0008 (Print) IS - 1532-7078 (Linking) VI - 31 IP - 4 DP - 2026 Jul-Aug TI - Brain Activity of Young Children in Bangladesh Is Associated With Biopsychosocial Conditions at the Individual-, Family-, and Household-Level. PG - e70108 LID - 10.1111/infa.70108 [doi] LID - e70108 AB - Adversities in early life compromise children's nurturing care and impact their development. This study explored the biopsychosocial conditions associated with electroencephalography (EEG)-based brain activity in children living in rural Bangladesh, a setting with high rates of malnutrition and suboptimal psychosocial stimulation. In a substudy of the Benefits and Risks of Iron Supplementation in Children (BRISC) study in Bangladesh, we recorded resting EEG brain activity in a random subsample of 440 children at 11 months and 594 children at 20 months of age. EEG band power measures were derived for delta, theta, alpha, and beta power bands. Validated tools were used to assess maternal depression, household food insecurity, and psychosocial stimulation. Children's anthropometry, venous hemoglobin and ferritin concentrations, and inflammation were also measured. Linear regression analyses were conducted to identify the concurrent and lagged biopsychosocial conditions associated with EEG-based brain activity. Growth, nutritional status, psychosocial stimulation, and household food security were associated with concurrent and lagged brain activity. The direction of association differed by EEG frequency band, but the majority of biopsychosocial conditions were positively associated with activity in the higher frequency bands and negatively with lower frequency bands. Our findings indicate that brain activity in children can be influenced by a range of biopsychosocial adversities. Children's nutrition, quality and quantity of psychosocial stimulation, and food security influence their current and later brain activity in this resource-limited setting in South Asia. TRIAL REGISTRATION: ACTRN12617000660381. CI - (c) 2026 The Author(s). Infancy published by Wiley Periodicals LLC on behalf of International Congress of Infant Studies. FAU - Larson, Leila M AU - Larson LM AUID- ORCID: 0000-0002-2570-7323 AD - Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. FAU - Feuerriegel, Daniel AU - Feuerriegel D AUID- ORCID: 0000-0002-0357-1920 AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Lall, Gitanjali AU - Lall G AD - Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. FAU - Imrul Hasan, Mohammed AU - Imrul Hasan M AD - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. AD - Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. FAU - Braat, Sabine AU - Braat S AD - Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. AD - Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. AD - Department of Infectious Diseases at the Peter Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Jin, Jerry AU - Jin J AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. AD - Department of Infectious Diseases at the Peter Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Biggs, Beverley-Ann AU - Biggs BA AD - Department of Infectious Diseases at the Peter Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia. AD - The Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. FAU - Bode, Stefan AU - Bode S AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. AD - Division of Science, New York University Abu Dhabi, Abu Dhabi, UAE. FAU - Pasricha, Sant-Rayn AU - Pasricha SR AD - Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. AD - Diagnostic Haematology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. AD - Diagnostic Haematology and Clinical Haematology, The Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia. AD - Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Johnson, Katherine A AU - Johnson KA AUID- ORCID: 0000-0002-2029-163X AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Hamadani, Jena D AU - Hamadani JD AD - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. LA - eng GR - GNT1103262/National Health and Medical Research Council/ GR - GNT1159151/National Health and Medical Research Council/ GR - GNT1158696/National Health and Medical Research Council/ GR - University of Melbourne/ PT - Journal Article PL - United States TA - Infancy JT - Infancy : the official journal of the International Society on Infant Studies JID - 100890607 SB - IM MH - Humans MH - Bangladesh MH - Female MH - Electroencephalography MH - Infant MH - Male MH - *Brain/physiology MH - Nutritional Status MH - Rural Population MH - *Child Development/physiology MH - Family Characteristics PMC - PMC13380311 COIS- The authors declare no conflicts of interest. EDAT- 2026/07/19 01:03 MHDA- 2026/07/19 01:04 PMCR- 2026/07/18 CRDT- 2026/07/18 13:43 PHST- 2026/05/29 00:00 [revised] PHST- 2025/07/31 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/19 01:04 [medline] PHST- 2026/07/19 01:03 [pubmed] PHST- 2026/07/18 13:43 [entrez] PHST- 2026/07/18 00:00 [pmc-release] AID - INFA70108 [pii] AID - 10.1111/infa.70108 [doi] PST - ppublish SO - Infancy. 2026 Jul-Aug;31(4):e70108. doi: 10.1111/infa.70108. PMID- 42470024 OWN - NLM STAT- MEDLINE DCOM- 20260718 LR - 20260903 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 29 DP - 2026 Jul 17 TI - Dose-response associations between physical fitness components and anxiety in Chinese university students: A focus on cardiorespiratory fitness and vital capacity. PG - e49804 LID - 10.1097/MD.0000000000049804 [doi] LID - e49804 AB - Despite the mental health benefits of physical activity, the specific dose-response relationship between objectively measured physical fitness (especially cardiorespiratory fitness and lung capacity) and anxiety in youth is unclear. The purpose of this study is to explore the association between these indicators in Chinese college students. A cross-sectional analysis of 3878 undergraduate students was conducted. Anxiety was assessed using the generalized anxiety disorder 7-item scale (a score of >/=10 was positive). Objective measurement of cardiopulmonary function, muscle strength, flexibility and vital capacity, and according to national standards, excellent, good, pass, fail 4 grades. After controlling for demographics and health behaviors, adjusted odds ratios (aOR) and 95% confidence intervals (CIs) for anxiety were calculated by multivariate logistic regression and analyzed graphically. The prevalence of anxiety was 24.9%. Cardiopulmonary function and muscle strength showed a clear negative dose-response relationship: compared with the excellent grade, the failing grade had the highest cardiopulmonary function related anxiety ratio (aOR = 2.15, 95% CI: 1.50-3.08), followed by muscle strength (aOR = 1.75, 95% CI: 1.18-2.60). There was a significant nonlinear association between spirometry and anxiety, with only a significantly higher risk of passing grade (aOR = 1.85, 95% CI: 1.35-2.53). Comprehensive effect analysis showed that students who failed both heart, lung and muscle had the highest risk. Among the behavioral factors, poor sleep quality (aOR = 2.85) and frequent staying up late (aOR = 1.65) were most strongly associated with anxiety. This study demonstrates a significant negative dose-response association between higher levels of cardiorespiratory fitness and muscle strength and lower odds of anxiety in college students, while vital capacity shows a complex nonlinear relationship. Improving these physical fitness components may be a feasible strategy associated with lower anxiety risk, although causality cannot be inferred from the cross-sectional design. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Gao, Mengchan AU - Gao M AD - School of Physical Education, Changzhou Vocational Institute of Industry Technology, Changzhou, China. FAU - Yin, Hang AU - Yin H AD - School of Sports Science, Anshan Normal University, Anshan, China. FAU - Gao, Caizhu AU - Gao C AD - School of Sports Science, Anshan Normal University, Anshan, China. FAU - Wang, Huidong AU - Wang H AUID- ORCID: 0009-0005-2586-7860 AD - School of Physical Education, Changzhou Vocational Institute of Industry Technology, Changzhou, China. LA - eng GR - L24BED001/the Education Project of Liaoning Provincial Social Science Planning Fund in 2024/ PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - *Cardiorespiratory Fitness/physiology/psychology MH - China/epidemiology MH - *Anxiety/epidemiology MH - Universities MH - Young Adult MH - Vital Capacity/physiology MH - Muscle Strength/physiology MH - *Physical Fitness/physiology MH - Adolescent MH - Adult PMC - PMC13384608 OTO - NOTNLM OT - anxiety OT - cross-sectional study OT - dose-response relationship OT - physical fitness OT - university students OT - vital Capacity COIS- The authors have no conflicts of interest to declare. EDAT- 2026/07/18 06:38 MHDA- 2026/07/18 06:39 PMCR- 2026/07/17 CRDT- 2026/07/18 01:01 PHST- 2026/01/31 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/18 06:39 [medline] PHST- 2026/07/18 06:38 [pubmed] PHST- 2026/07/18 01:01 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 00005792-202607170-00057 [pii] AID - MD-D-26-01812 [pii] AID - 10.1097/MD.0000000000049804 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jul 17;105(29):e49804. doi: 10.1097/MD.0000000000049804. PMID- 42469891 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260921 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Jul 17 TI - Association between Low carbohydrate diet with anthropometric indexes among overweight and obese women. LID - 10.1186/s41043-026-01292-z [doi] LID - 189 AB - BACKGROUND: The important association between Low-Carbohydrate Diets (LCD), lipid and glycemic control, and weight loss has been well-depicted in previous research. However, the relationship between LCD, lipid and glycemic profiles, and new anthropometric markers such as the a-Body Shape Index (ABSI) and the Obesity Degree (OD) has not been established. Therefore, this cross-sectional study aimed to investigate the relationship between LCD, lipid, and glycemic profiles, with the ABSI and the OD in overweight and obese women. METHODS: A cohort of 290 overweight and obese women (body mass index (BMI) > 25 kg.m(- 2)), aged 18-48 years old, were included in this cross-sectional study. The amount of dietary intake and LCD score were established using a valid and reliable Questionnaire of Food Frequency (FFQ) containing 147 items. Body composition was assessed via bioelectrical impedance analysis. The anthropometric measurements and serum profiles were measured by standard protocols. physical activity was also assessed. The ABSI index was also measured by its formula. Models were adjusted for age, energy intake, and physical activity(PA) and BMI. RESULTS: It was observed that higher LCD score was significantly associated with lower OD (p = 0.041); however, no significant relationship was observed between LCD score and ABSI even after adjusting for potential confounders (age, energy intake, physical activity, economic status, education status (p = 0.168). In a linear logistic regression following of LCD score and controlled with potential confounders, a lower level of -0.77 kg, -1.043%, and - 1.98 cm were observed in visceral fat (beta = -0.77, 95%CI = -1.51, -0.02, p = 0.049), body fat percentage (beta = -1.043, 95%CI = -2.31, -0.22, p = 0.020), and waist circumstance (beta = -1.98, 95%CI = -4.01, 0.04, p = 0.044), respectively. In addition, participants with a higher quartile of LCD score, which indicated higher LCD score, had higher high-density lipoprotein (HDL) (p = 0.041) concentrations. CONCLUSION: A higher LCD score was associated with lower OD, body fat (BF), visceral fat, and waist circumference, and with higher HDL in overweight and obese women. However, there are no associations between LCD and ABSI. CI - (c) 2026. The Author(s). FAU - Karimi, Mehdi AU - Karimi M AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. FAU - Shiraseb, Farideh AU - Shiraseb F AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box:14155-6117, Tehran, Iran. FAU - Mirzababaei, Atieh AU - Mirzababaei A AD - Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. ati_babaee@yahoo.com. AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box:14155-6117, Tehran, Iran. ati_babaee@yahoo.com. FAU - Khadem, Alireza AU - Khadem A AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box:14155-6117, Tehran, Iran. FAU - Zarrinvafa, Zeinab AU - Zarrinvafa Z AD - Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran. FAU - Khorraminezhad, Leila AU - Khorraminezhad L AD - Endocrinology and Nephrology Unit, Research Center, CHU de Quebec-Laval University, Quebec, Canada. FAU - Bagheri, Reza AU - Bagheri R AD - Department of Exercise Physiology, University of Isfahan, Isfahan, Iran. FAU - Wong, Alexei AU - Wong A AD - Department of Health and Human Performance, Marymount University, Arlington, USA. FAU - Mirzaei, Khadijeh AU - Mirzaei K AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box:14155-6117, Tehran, Iran. mirzaei_kh@tums.ac.ir. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260717 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 RN - 0 (Blood Glucose) RN - 0 (Lipids) SB - IM MH - Humans MH - Female MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - *Obesity/blood/diet therapy MH - Body Mass Index MH - *Overweight/blood MH - Adolescent MH - *Diet, Carbohydrate-Restricted MH - Young Adult MH - Body Composition MH - Anthropometry MH - Energy Intake MH - Blood Glucose/metabolism MH - Lipids/blood PMC - PMC13491580 COIS- Declarations. Ethics approval and consent to participate: The study protocol has been approved by the ethics committee of the Research Center of Tehran University of Medical Sciences (TUMS) with the following identification: IR.TUMS.VCR.REC.1398.819. Consent for publication: Each participant was wholly informed about the study protocol and provided a written and informed consent form before participating in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/07/18 00:38 MHDA- 2026/08/21 05:35 PMCR- 2026/07/17 CRDT- 2026/07/18 00:00 PHST- 2025/09/29 00:00 [received] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/08/21 05:35 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/18 00:00 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.1186/s41043-026-01292-z [pii] AID - 1292 [pii] AID - 10.1186/s41043-026-01292-z [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jul 17;45(1):189. doi: 10.1186/s41043-026-01292-z. PMID- 42469779 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260912 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 27 IP - 1 DP - 2026 Jul 17 TI - Prevalence and associated factors of musculoskeletal pain among university students in Saudi Arabia: an analytical cross-sectional study. LID - 10.1186/s12891-026-10228-x [doi] LID - 764 AB - BACKGROUND: Musculoskeletal pain is common among university students and may be influenced by prolonged sitting, digital-device use, suboptimal ergonomic practices, and low physical activity. However, evidence from Saudi university settings remains limited. This study aimed to estimate the 12-month prevalence and anatomical distribution of musculoskeletal pain among university students at Al-Baha University and to examine its associations with ergonomic behaviours and physical activity levels. METHODS: This analytical cross-sectional study was conducted among university students aged >/= 18 years at Al-Baha University. Data were collected using self-administered questionnaires capturing demographics, 12-month musculoskeletal pain and affected body regions assessed using the Nordic Musculoskeletal Questionnaire (NMQ), and ergonomic practices. Participants reported physical-activity summaries from their smartphone health applications (Google Fit and Apple Health). Descriptive statistics, chi-square tests, Mann-Whitney U tests, and multivariable logistic regression were used to analyse the data and identify factors independently associated with musculoskeletal pain. Results are presented as odds ratios (ORs) with 95% confidence intervals (CIs), and model discrimination was assessed using the area under the receiver operating characteristic curve (AUC). RESULTS: Among 675 students, the mean age was 22.26 +/- 3.36 years; most participants were male (74.4%) and enrolled in health-sciences programs (85.2%). Overall, 85.0% reported musculoskeletal pain in the previous 12 months. The neck (47.6%), lower back (46.8%), and shoulders (34.2%) were the most affected regions. In multivariable analysis, internship-level students had higher odds of pain (OR = 15.05, 95% CI: 2.91-77.78, p = 0.001), and sitting 6-8 h/day was associated with higher odds of pain (OR = 13.95, 95% CI: 4.13-47.19, p < 0.001). Low daily physical activity time (< 15 min/day) was also associated with higher odds of pain (OR = 5.70, 95% CI: 2.14-15.16, p < 0.001). The model showed acceptable discrimination (AUC = 0.793, 95% CI: 0.742-0.843, p < 0.001), although specificity and calibration were limited. CONCLUSIONS: Musculoskeletal pain was common among university students at Al-Baha University, particularly in the neck, lower back, and shoulders. The findings suggest that prolonged sitting and selected physical-activity indicators are important associated factors. These findings may inform campus-based strategies promoting regular movement breaks, ergonomic study practices, and physical activity. CI - (c) 2026. The Author(s). FAU - Alghamdi, Wael AU - Alghamdi W AUID- ORCID: 0000-0002-2297-3255 AD - Faculty of Nursing, Al-Baha University, Al-Baha, Saudi Arabia. waelalghamdi@bu.edu.sa. LA - eng PT - Journal Article DEP - 20260717 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Cross-Sectional Studies MH - Male MH - *Musculoskeletal Pain/epidemiology/diagnosis MH - Female MH - Young Adult MH - *Students/statistics & numerical data MH - Universities MH - Prevalence MH - Adult MH - Risk Factors MH - Adolescent MH - Ergonomics MH - Surveys and Questionnaires MH - Exercise PMC - PMC13560120 OTO - NOTNLM OT - Ergonomics OT - Musculoskeletal pain OT - Physical activity OT - Prevalence OT - Sedentary behaviour OT - University students COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Research Ethics Committee/Institutional Review Board at Al-Baha University (Approval No. 46121733/2025, Date: 22 March 2025). The study was conducted in accordance with the principles of the Declaration of Helsinki. All participants provided informed consent before participating in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/18 00:38 MHDA- 2026/09/11 05:36 PMCR- 2026/07/17 CRDT- 2026/07/17 23:57 PHST- 2026/01/14 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/11 05:36 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 23:57 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.1186/s12891-026-10228-x [pii] AID - 10228 [pii] AID - 10.1186/s12891-026-10228-x [doi] PST - epublish SO - BMC Musculoskelet Disord. 2026 Jul 17;27(1):764. doi: 10.1186/s12891-026-10228-x. PMID- 42469757 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Jul 17 TI - Personality-based subgroup identification and psychological symptom patterns in adolescent male new psychoactive substance users: implications for targeted intervention. LID - 10.1186/s12888-026-08420-3 [doi] LID - 784 AB - BACKGROUND/OBJECTIVES: Adolescent new psychoactive substance (NPS) users represent a high-risk population with complex psychological needs that remain insufficiently characterized, limiting the development of targeted rehabilitation interventions. This study aimed to (1) characterize the personality trait profiles and psychological symptom patterns of adolescent NPS users undergoing compulsory drug rehabilitation relative to normative standards; (2) identify empirically derived personality-based subgroups within this population; and (3) examine differential psychological symptom patterns across identified subgroups to inform precision intervention design. METHODS: A cross-sectional study was conducted with 60 adolescent male participants (mean age = 17.2 +/- 1.9 years) recruited from a compulsory drug rehabilitation facility in Shandong Province, China. Participants completed a multimodal assessment battery comprising Cattell's 16 Personality Factor Questionnaire (16PF), the Personality Diagnostic Questionnaire-4+ (PDQ-4+), and the Symptom Checklist-90-Revised (SCL-90-R). Personality-based subgroups were identified using a two-stage cluster analysis (Ward's method followed by K-means), with cluster quality evaluated via Average Silhouette Width and split-sample Adjusted Rand Index. Between-cluster differences in psychological symptom profiles were examined using one-way ANOVA with Tukey post-hoc comparisons. Hierarchical multiple regression identified independent personality predictors of overall psychological distress (SCL-90-R Global Severity Index, GSI). RESULTS: Fourteen of 16 personality factors deviated significantly from Chinese adolescent norms (all corrected p < .05), with the largest deviations observed for Tension (Q4; d = 1.38), Rule-Consciousness (G; d = 1.30 downward arrow), Apprehension (O; d = 1.24), and Emotional Stability (C; d = 1.13 downward arrow). Overall psychological distress was pervasive, with 81.7% of participants exceeding the GSI clinical significance threshold (GSI >/= 1.0; mean GSI = 1.52 +/- 0.43). Paranoid Ideation emerged as the most severely elevated SCL-90-R dimension (d = 1.39), followed by Interpersonal Sensitivity (d = 1.09) and Anxiety (d = 1.02). Cluster analysis identified three empirically stable personality-based subgroups: Dysregulated-Hostile (n = 22, 36.7%), Anxious-Withdrawn (n = 21, 35.0%), and Impulsive-Sensation-Seeking (n = 17, 28.3%; Average Silhouette Width = 0.58; split-sample ARI = 0.71). The three clusters demonstrated clinically meaningful differential symptom profiles: the Dysregulated-Hostile cluster was characterized by elevated Hostility and Paranoid Ideation; the Anxious-Withdrawn cluster by elevated Anxiety, Depression, and Obsessive-Compulsive symptoms; and the Impulsive-Sensation-Seeking cluster by relatively lower overall distress with elevated personality disorder tendencies. Hierarchical regression revealed that 16PF personality factors explained an additional 48.7% of variance in GSI beyond demographic covariates (DeltaR(2) = 0.487, DeltaF(6, 49) = 14.38, p < .001), with Tension (Q4; beta = 0.318), Emotional Stability (C; beta = -0.312), and Apprehension (O; beta = 0.287) as the strongest independent predictors. CONCLUSIONS: Adolescent NPS users in compulsory rehabilitation present a distinctive high-risk personality configuration and a substantial psychological distress burden that is not uniformly distributed across the population. Three empirically derived personality-based subgroups with differential symptom profiles provide preliminary, hypothesis-generating evidence that should be validated in a larger, multisite cohort before informing the development of differentiated, precision intervention strategies. Personality assessment at treatment intake-particularly targeting Tension, Emotional Stability, and Apprehension-offers clinically meaningful predictive information for distress severity that substantially exceeds demographic screening alone. These findings complement the gut microbiota-exercise intervention framework being developed in our companion, currently in-press trial and represent a critical step toward a precision medicine model for adolescent NPS rehabilitation that integrates personality-based stratification with physiologically targeted exercise interventions. CI - (c) 2026. The Author(s). FAU - Yang, Jianlou AU - Yang J AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. FAU - Jin, Xin AU - Jin X AD - Department of Police Practical Skills Teaching and Research, Shandong Judicial Police Vocational College, Jinan, Shandong, 250200, China. FAU - Shi, Lei AU - Shi L AD - Rehabilitation Training Center, Shandong Luzhong Compulsory Isolation Drug Rehabilitation Center, Zibo, Shandong, 255311, China. FAU - Shi, Dapeng AU - Shi D AD - Rehabilitation Training Center, Shandong Luzhong Compulsory Isolation Drug Rehabilitation Center, Zibo, Shandong, 255311, China. FAU - Cui, Jingjing AU - Cui J AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. FAU - Wang, Kaixu AU - Wang K AD - Rehabilitation Training Center, Shandong Luzhong Compulsory Isolation Drug Rehabilitation Center, Zibo, Shandong, 255311, China. FAU - Liu, Haoyu AU - Liu H AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. FAU - Xing, Xiaodong AU - Xing X AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. FAU - Dong, Chen AU - Dong C AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. dongchen@sdpei.edu.cn. LA - eng GR - 25DJYJ13/Social Science Planning Project of Shandong Province/ PT - Journal Article DEP - 20260717 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 RN - 0 (Psychotropic Drugs) SB - IM MH - *Substance-Related Disorders/psychology/rehabilitation MH - *Psychotropic Drugs/adverse effects MH - China MH - Cluster Analysis MH - Humans MH - Male MH - Adolescent PMC - PMC13660315 OTO - NOTNLM OT - 16PF OT - Adolescents OT - Cluster analysis OT - Compulsory drug rehabilitation OT - New psychoactive substances OT - Personality traits OT - Precision intervention OT - Psychological symptoms OT - SCL-90-R COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Review Committee of the School of Sport Management, Shandong Sport University (Approval Number: SD2026043) in accordance with the Declaration of Helsinki. Clinical trial number: not applicable. Consent for publication: All authors gave their consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/07/18 00:38 MHDA- 2026/10/13 05:31 PMCR- 2026/07/17 CRDT- 2026/07/17 23:57 PHST- 2026/04/30 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/13 05:31 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 23:57 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.1186/s12888-026-08420-3 [pii] AID - 8420 [pii] AID - 10.1186/s12888-026-08420-3 [doi] PST - epublish SO - BMC Psychiatry. 2026 Jul 17;26(1):784. doi: 10.1186/s12888-026-08420-3. PMID- 42469521 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Population-specific dental maturity scores for forensic age estimation in turkish children: a percentile-based modeling approach. PG - 3861-3872 LID - 10.1007/s00414-026-03926-7 [doi] AB - Accurate age estimation in children and adolescents is essential for forensic identification; however, the direct application of dental age estimation methods developed from Western European populations may introduce systematic bias when applied to other populations. This study aimed to develop and validate population-specific age estimation models based on the Dental Maturity Score (DMS) using data obtained from Turkish children. A total of 4,009 panoramic radiographs from individuals aged 2-18 years (2,035 males and 1,974 females) were included. Of these, 3,206 individuals constituted the model development (training) cohort and 803 the independent validation (test) cohort. The seven left permanent mandibular teeth were assessed according to the Demirjian staging system, and sex-specific DMSs were calculated. The relationship between chronological age and DMS was modeled using moving average, Locally Weighted Scatterplot Smoothing (LOWESS), the Lambda-Mu-Sigma (LMS) method, piecewise polynomial regression, and polynomial- and spline-based quantile regression. Model performance was evaluated using the coefficient of determination (R(2)), mean absolute error (MAE), and Bland-Altman agreement analysis. Among the evaluated approaches, the polynomial- and spline-based quantile regression models demonstrated the best overall performance. In the independent validation cohort, the polynomial-based quantile regression model achieved an R(2) of 0.94 and an MAE of 0.75 years in males, and an R(2) of 0.92 and an MAE of 1.09 years in females. Among the population-specific models developed for Turkish children, the polynomial-based quantile regression model demonstrated the highest predictive accuracy and consistent performance in the independent validation cohort, indicating that it is a suitable approach for forensic age estimation. In contrast, the spline-based quantile regression model provides a useful reference framework for the clinical assessment of dental development. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Zilan, Sumeyye AU - Zilan S AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum, Turkey. FAU - Sengul, Fatih AU - Sengul F AUID- ORCID: 0000-0001-6087-148X AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum, Turkey. fsengul@atauni.edu.tr. LA - eng PT - Journal Article PT - Validation Study DEP - 20260718 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Turkey MH - Child MH - Child, Preschool MH - Male MH - Radiography, Panoramic MH - Female MH - Adolescent MH - Regression Analysis MH - *Models, Statistical MH - Dentition, Permanent OTO - NOTNLM OT - Demirjian method OT - Dental maturity score OT - Forensic age estimation OT - Forensic odontology OT - Quantile regression OT - Turkish population COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. Ethical approval was obtained from the Clinical Research Ethics Committee of Ataturk University Faculty of Medicine (Approval No. B.30.ATA.0.01.00/193; February 28, 2025). Because of the retrospective design of the study, the requirement for informed consent was waived by the Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/07/18 00:38 MHDA- 2026/10/12 17:30 CRDT- 2026/07/17 23:23 PHST- 2026/02/13 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 23:23 [entrez] AID - 10.1007/s00414-026-03926-7 [pii] AID - 10.1007/s00414-026-03926-7 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):3861-3872. doi: 10.1007/s00414-026-03926-7. Epub 2026 Jul 18. PMID- 42469299 OWN - NLM STAT- Publisher LR - 20260717 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 17 TI - Germany's youth city versus rural dwellers engage in more moderate-to-vigorous physical activity. LID - 10.1038/s41598-026-61980-y [doi] AB - Rapid urbanization poses the question how city living impacts human physical activity, especially in the population of vulnerable youth. This study aimed to examine urban-rural differences in moderate-to-vigorous physical activity (MVPA) among children and adolescents in Germany in a large German national study, across two independent samples (Discovery study: N = 2734; Replication study: N = 1196) of children and adolescents (6-17 years), with accelerometer-assessed MVPA, and across two different urbanicity assessments. In both studies, city youth engaged in more total MVPA than rural youth and were more likely to comply with the physical activity guidelines of the World Health Organization. While city living and total MVPA were independent of age and gender, age groups differed regarding physical activity guideline compliance. These results point towards a potential positive implication of urbanization for physical activity and suggest actions to target rural areas for physical activity promotion, if findings are validated towards causality in future studies. CI - (c) 2026. The Author(s). FAU - Reichert, Markus AU - Reichert M AD - Department of Sport and Exercise Science, Faculty of Natural and Life Sciences, University of Salzburg, Schlossallee 49, 5400, Hallein, Austria. markus.reichert@plus.ac.at. AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. markus.reichert@plus.ac.at. AD - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. markus.reichert@plus.ac.at. FAU - Nigg, Carina AU - Nigg C AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. carina.nigg2@unibe.ch. AD - Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland. carina.nigg2@unibe.ch. FAU - Fiedler, Janis AU - Fiedler J AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Brussler, Sarah AU - Brussler S AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Burchartz, Alexander AU - Burchartz A AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Jekauc, Darko AU - Jekauc D AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Limberger, Matthias F AU - Limberger MF AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Krell-Roesch, Janina AU - Krell-Roesch J AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - von Haaren-Mack, Birte AU - von Haaren-Mack B AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Ebner-Priemer, Ulrich W AU - Ebner-Priemer UW AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Niessner, Claudia AU - Niessner C AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Schipperijn, Jasper AU - Schipperijn J AD - Department of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Woll, Alexander AU - Woll A AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. LA - eng GR - 01ER1503/Federal Ministry of Education and Research, Germany/ PT - Journal Article DEP - 20260717 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Adolescents OT - Children OT - Cities OT - Physical activity guidelines OT - Urbanization COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/18 04:01 MHDA- 2026/07/18 04:01 CRDT- 2026/07/17 23:17 PHST- 2024/08/26 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/18 04:01 [medline] PHST- 2026/07/18 04:01 [pubmed] PHST- 2026/07/17 23:17 [entrez] AID - 10.1038/s41598-026-61980-y [pii] AID - 10.1038/s41598-026-61980-y [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 17. doi: 10.1038/s41598-026-61980-y. PMID- 42468724 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260923 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 9 DP - 2026 Sep TI - Longitudinal Changes in Healthy Eating Index-2020 Score and Impacts on Body Mass Index among Adolescents in the Growing Up Today Study: A Prospective Cohort Study. PG - 101735 LID - S0022-3166(26)00384-6 [pii] LID - 10.1016/j.tjnut.2026.101735 [doi] AB - BACKGROUND: The Dietary Guidelines for Americans informs the design of nutrition programs targeted at improving health across the life course, including for adolescents, a population with suboptimal diet quality. The associations between adherence to the Guidelines and longitudinal health outcomes among adolescents, however, are unclear. OBJECTIVES: We leveraged 7 y of data from the Growing Up Today Study, a prospective cohort study, to evaluate associations between concurrent changes in total or component Healthy Eating Index-2020 (HEI-2020) scores, a measure of adherence to the Guidelines, and changes in body mass index [BMI (in kg/m(2))], a targeted outcome of the Guidelines, in United States adolescents. METHODS: We analyzed data from a prospective longitudinal cohort with enrollment cycles in 1996 (n = 14,233) and 2004 (n = 7898). We calculated HEI-2020 and BMI from validated food frequency questionnaires and self-reported height/weight. Multivariate fixed-effects regression models, stratified by sex, were used to estimate associations between within-child changes in HEI-2020 and changes in BMI. We assessed interactions by concurrent adolescent BMI category and age. RESULTS: After covariate adjustment, a 10-point increase in total HEI-2020 was associated with 0.09 [95% confidence interval (CI): 0.051, 0.121] and 0.04 (95% CI: 0.011, 0.066) decreases in BMI for boys and girls, respectively. Of the 13 HEI-2020 components, only the greens/beans, fatty acids adequacy scores, and saturated fatty acid moderation scores were inversely related to BMI. A 1-point increase in the dairy component was associated with mean increases of 0.02 for boys and girls. Associations between total HEI-2020 and BMI were stronger for youth classified as overweight/obese and for older age, although associations were still relatively small. CONCLUSIONS: Improved adherence to the Dietary Guidelines, 2020-2025, was associated with small, though clinically insignificant, decreases in mean BMI among adolescents. Relationships for specific HEI components were heterogeneous and warrant further study. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Lee, Matthew M AU - Lee MM AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. Electronic address: matthewlee@kurtosisresearch.com. FAU - Poole, Mary Kathryn AU - Poole MK AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Chen, Jarvis T AU - Chen JT AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Gortmaker, Steven L AU - Gortmaker SL AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Stephenson, Briana Joy K AU - Stephenson BJK AD - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Haines, Jess AU - Haines J AD - Department of Family Relations & Applied Nutrition, University of Guelph, Guelph, ON, Canada. FAU - Chavarro, Jorge E AU - Chavarro JE AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. FAU - Diamantis, Dimitrios V AU - Diamantis DV AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Kenney, Erica L AU - Kenney EL AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. LA - eng GR - T32 HL098048/HL/NHLBI NIH HHS/United States GR - U01 CA176726/CA/NCI NIH HHS/United States GR - U01 HL145386/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260717 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Humans MH - *Body Mass Index MH - Adolescent MH - Female MH - Prospective Studies MH - *Diet, Healthy MH - Male MH - Longitudinal Studies MH - Nutrition Policy MH - Child MH - United States PMC - PMC13531323 MID - NIHMS2202929 OTO - NOTNLM OT - BMI OT - Dietary Guidelines for Americans OT - Growing Up Today Study OT - Healthy Eating Index OT - child nutrition OT - diet quality OT - longitudinal cohort study OT - nutrition epidemiology OT - obesity OT - prospective cohort study COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/18 00:38 MHDA- 2026/09/04 23:36 PMCR- 2026/09/02 CRDT- 2026/07/17 19:12 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 19:12 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - S0022-3166(26)00384-6 [pii] AID - 10.1016/j.tjnut.2026.101735 [doi] PST - ppublish SO - J Nutr. 2026 Sep;156(9):101735. doi: 10.1016/j.tjnut.2026.101735. Epub 2026 Jul 17. PMID- 42468723 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261013 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 156 IP - 10 DP - 2026 Oct TI - Impact of Behavior Change Communication and Small-Quantity-Lipid-Based Nutrient Supplementation on Nutrient Intake and Adequacy among 12-Month-Old Infants in Rural Zimbabwe: Substudy of a Cluster-Randomized Trial. PG - 101728 LID - S0022-3166(26)00377-9 [pii] LID - 10.1016/j.tjnut.2026.101728 [doi] AB - BACKGROUND: Poor complementary feeding practices between 6 and 24 mo are a major driver of infant undernutrition. We evaluated an infant and young child feeding (IYCF) intervention combining behavior change communication (BCC) and small-quantity-lipid-based nutrient supplement (SQ-LNS) within the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) cluster-randomized trial in rural Zimbabwe. OBJECTIVES: We aimed to assess the impact of the IYCF intervention on infant nutrient intake from complementary foods assessed by 24-h dietary recall. METHODS: The SHINE trial was a cluster-randomized 2 x 2 factorial trial assessing individual and combined effects of IYCF and water, sanitation, and hygiene (WASH) interventions on stunting and anemia in rural Zimbabwe (NCT01824940). We conducted multipass 24-h dietary recalls among 194 randomly selected caregivers of 12-mo-old infants. Nutrient intake and adequacy were compared between children in the IYCF intervention arms (BCC + daily SQ-LNS; n = 99) and non-IYCF arms (standard of care with or without WASH; n = 94), with analyses conducted both including and excluding the contribution of SQ-LNS-derived nutrients, using the measurement-error method. RESULTS: Energy intake was higher in IYCF compared with non-IYCF infants [531 (404) compared with 426 (272) kcal/d; P = 0.03]. IYCF infants had greater micronutrient intake and adequacy (vitamin A, folate, calcium, iron and zinc; all P < 0.01). However, many children still did not meet their dietary requirements, particularly for calcium and folate. Intakes of all macronutrients and micronutrients from nonsupplement foods did not differ significantly between the IYCF and non-IYCF groups, which suggests that the SQ-LNS provided all the nutritional benefit and did not replace nonsupplement food intake. CONCLUSIONS: The IYCF intervention improved energy and micronutrient intake and improved micronutrient adequacy, primarily through SQ-LNS, with no displacement of other food intake. However, no differences in intake from nonsupplement foods were observed, indicating that BCC alone had no effect on complementary feeding. This trial was registered at clinicaltrials.gov as NCT01883193 (https://clinicaltrials.gov/study/NCT01824940). CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Fundira, Dadirai AU - Fundira D AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe. FAU - Mbuya, Mduduzi Nn AU - Mbuya MN AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Global Alliance for Improved Nutrition, Geneva, Switzerland. FAU - Larson, Elisabeth A AU - Larson EA AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Chasekwa, Bernard AU - Chasekwa B AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe. FAU - Humphrey, Jean H AU - Humphrey JH AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Pelto, Gretel AU - Pelto G AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Rasmussen, Kathleen M AU - Rasmussen KM AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Stoltzfus, Rebecca J AU - Stoltzfus RJ AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Smith, Laura E AU - Smith LE AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Department of Public and Ecosystem Health, Cornell University, Ithaca, NY, United States. Electronic address: les36@cornell.edu. LA - eng SI - ClinicalTrials.gov/NCT01824940 SI - ClinicalTrials.gov/NCT01883193 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260717 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Lipids) RN - 0 (Micronutrients) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Infant MH - Zimbabwe MH - *Dietary Supplements MH - *Infant Nutritional Physiological Phenomena MH - Female MH - Male MH - Rural Population MH - Energy Intake MH - *Nutrients/administration & dosage MH - *Lipids/administration & dosage MH - Micronutrients/administration & dosage MH - *Dietary Fats/administration & dosage MH - Diet OTO - NOTNLM OT - behavior change communication OT - dietary recall OT - macronutrient intake OT - micronutrient intake OT - small-quantity-lipid-based nutrient supplement COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/18 00:38 MHDA- 2026/10/09 23:31 CRDT- 2026/07/17 19:12 PHST- 2026/01/09 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/10/09 23:31 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 19:12 [entrez] AID - S0022-3166(26)00377-9 [pii] AID - 10.1016/j.tjnut.2026.101728 [doi] PST - ppublish SO - J Nutr. 2026 Oct;156(10):101728. doi: 10.1016/j.tjnut.2026.101728. Epub 2026 Jul 17. PMID- 42467974 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261016 IS - 1473-5687 (Electronic) IS - 0954-691X (Linking) VI - 38 IP - 11 DP - 2026 Nov 1 TI - COMPLY-CATeD: Celiac Adherence in Teens Diagnosed: an Italian multicentric study. PG - 1305-1310 LID - 10.1097/MEG.0000000000003227 [doi] AB - OBJECTIVES: Gluten-free diet (GFD) is, to date, the only effective therapeutic intervention for coeliac disease (CeD). Evaluation of dietary adherence is of the utmost importance in the management of CeD. However, in the paediatric population, there is limited data concerning the adherence to the GFD in patients diagnosed via bioptic confirmation compared to those diagnosed through the biopsy-sparing method, according to the ESPGHAN 2012 guidelines. In this multicentric study, we investigated dietary adherence in a group of adolescents with CeD, comparing patients diagnosed with the two different diagnostic modalities, and we proposed the validation of an evaluation tool for the GFD compliance in this population. METHODS: A total of 206 patients aged 14-18 years, diagnosed between 2012 and 2019, all with CeD and on a GFD for at least 2 years, were included. Adherence was assessed using the Leffler questionnaire [Celiac Dietary Adherence Test (CDAT)] and the Biagi score. RESULTS: Among participants, 81.1% had been diagnosed through biopsy. No significant difference in Biagi scores was observed between the two groups ( P = 0.057). Regarding the CDAT, poor or suboptimal adherence (score: >/=13) was identified in 66 patients diagnosed by biopsy and 12 patients diagnosed by the biopsy-sparing approach ( P = 0.362). A multivariate analysis exploring the influence of diagnostic method, age at diagnosis, and education level on CDAT scores did not reach statistical significance ( P = 0.1, R2 = 0.031). CONCLUSION: Adherence to a GFD does not differ between adolescents diagnosed by biopsy and those diagnosed through the biopsy-sparing approach, irrespective of age at diagnosis or educational level. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Morelli, Annalisa AU - Morelli A AD - Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Pediatrics Section, University of Salerno, Baronissi. AD - Gastroenterology and Nutritional Rehabilitation Unit, 'Bambino Gesu' Children's Hospital, IRCCS. FAU - Montuori, Monica AU - Montuori M AD - Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome. FAU - Ferretti, Francesca AU - Ferretti F AD - Gastroenterology and Nutritional Rehabilitation Unit, 'Bambino Gesu' Children's Hospital, IRCCS. FAU - Diamanti, Antonella AU - Diamanti A AD - Gastroenterology and Nutritional Rehabilitation Unit, 'Bambino Gesu' Children's Hospital, IRCCS. FAU - Francisci, Silvia AU - Francisci S AD - Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome. FAU - Oliva, Salvatore AU - Oliva S AD - Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome. FAU - Dipasquale, Valeria AU - Dipasquale V AD - Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood 'G. Barresi', University of Messina, Messina. FAU - Romano, Claudio AU - Romano C AD - Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood 'G. Barresi', University of Messina, Messina. FAU - Monzani, Alice AU - Monzani A AD - Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara. FAU - Graziano, Francesco AU - Graziano F AD - Pediatric Unit, Villa Sofia Cervello Hospital, Palermo. FAU - Nosratian, Valentina AU - Nosratian V AD - Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genova. FAU - Malerba, Federica AU - Malerba F AD - Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genova. FAU - Crocco, Marco AU - Crocco M AD - Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genova. FAU - Banzato, Claudia AU - Banzato C AD - Department of Pediatrics, Woman's and Child's University Hospital of Verona, Verona. FAU - Valitutti, Francesco AU - Valitutti F AD - Department of Medicine and Surgery, Pediatrics section, University of Perugia, Perugia, Italy. FAU - Trovato, Chiara Maria AU - Trovato CM AD - Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome. CN - 'Food-induced disease' study group of SIGENP LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260930 PL - England TA - Eur J Gastroenterol Hepatol JT - European journal of gastroenterology & hepatology JID - 9000874 SB - IM MH - Humans MH - Adolescent MH - *Celiac Disease/diet therapy/diagnosis/psychology MH - *Diet, Gluten-Free MH - Female MH - *Patient Compliance/statistics & numerical data MH - Male MH - Italy MH - Biopsy MH - Surveys and Questionnaires MH - *Adolescent Behavior OTO - NOTNLM OT - coeliac disease in adolescents OT - dietary adherence OT - gluten-free diet EDAT- 2026/07/17 19:17 MHDA- 2026/10/05 17:31 CRDT- 2026/07/17 16:54 PHST- 2026/10/05 17:31 [medline] PHST- 2026/07/17 19:17 [pubmed] PHST- 2026/07/17 16:54 [entrez] AID - 00042737-990000000-00721 [pii] AID - 10.1097/MEG.0000000000003227 [doi] PST - ppublish SO - Eur J Gastroenterol Hepatol. 2026 Nov 1;38(11):1305-1310. doi: 10.1097/MEG.0000000000003227. Epub 2026 Sep 30. PMID- 42467965 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260907 IS - 2292-9495 (Electronic) IS - 2292-9495 (Linking) VI - 13 DP - 2026 Jul 17 TI - A Smartphone App to Improve Intuitive Eating and Diet Quality: Design and Usability Study. PG - e81439 LID - 10.2196/81439 [doi] LID - e81439 AB - BACKGROUND: Web-based and mobile phone-based apps have become widely available for dietary self-monitoring; however, their use may increase the risk of disordered eating. College students frequently demonstrate poor nutrient intake despite consumption of sufficient calories. One way to improve diet quality may be via the use of a smartphone app that encourages intuitive eating. OBJECTIVE: The purpose of this study was to improve diet quality among college students through the use of a novel smartphone app that promotes intuitive eating rather than calorie counting and weight loss. METHODS: The In2Eat iOS mobile app was developed in SwiftUI and stored user data in a Firebase database. A total of 45 college students completed assessments of intuitive eating, diet quality, and disordered eating before and after 4 weeks of using the In2Eat app. Users evaluated the usability of the app with the System Usability Scale (SUS). Engagement with the app was recorded as the total number of days a meal was logged, the total number of meals logged, and the average number of meals logged per day. RESULTS: After our 4-week intervention, dietary qualities that protect against chronic disease increased by 28%, fruit consumption increased by 63%, and skin antioxidant levels increased by 6.1% (Hedges g=0.16; mean difference 0.33, 95% bias corrected and accelerated [BCa] CI 0.04-0.61; P=.03). Global intuitive eating did not change during the user study; however, the unconditional permission to eat subscale increased (Hedges g=-0.28; mean difference 0.28, 95% BCa CI 0.07-0.49; P=.01, adjusted P=.07). Overall, disordered eating also did not change with app use, although dietary restraint decreased (Hedges g=-0.23; mean difference 0.30, 95% BCa CI -0.61 to -0.04; P=.04, adjusted P=.22). The average SUS score for the In2Eat app was 67.2 (SD 15.5). The number of days a meal was logged was positively correlated with SUS scores (r=0.28; P=.06), and the total number of meals logged had a monotonic association with app usability (rho=0.31; P=.04). When divided according to the low (mean 10.2, SD 5.3), medium (mean 26.3, SD 2.8), and high (mean 33.6, SD 3.8) number of days logging meals, participants with higher days of logging reported the app as more usable (H=6.75; P=.03). A regression analysis showed that 8% of the variance in system usability (R(2)=0.080; P=.31) was explained by app use; however, none of the individual predictors contributed substantially to the variance. CONCLUSIONS: An intuitive eating smartphone app can improve diet quality without increasing disordered eating. Results suggest that participants who logged more meals tended to rate the app as more usable. Further research is needed with a greater sample size after incorporating features to improve the app's usability. CI - (c)Mandy Korpusik, Delaram YazdanSepas, Hawley C Almstedt. Originally published in JMIR Human Factors (https://humanfactors.jmir.org), 17.07.2026. FAU - Korpusik, Mandy AU - Korpusik M AUID- ORCID: 0000-0002-1721-4473 AD - Department of Computer Science, Seaver College of Science and Engineering, Loyola Marymount University, Los Angeles, CA, United States. FAU - YazdanSepas, Delaram AU - YazdanSepas D AUID- ORCID: 0000-0001-7998-8792 AD - Department of Computer Science, Seaver College of Science and Engineering, Loyola Marymount University, Los Angeles, CA, United States. FAU - Almstedt, Hawley C AU - Almstedt HC AUID- ORCID: 0000-0002-4310-2424 AD - Department of Health and Human Sciences, Seaver College of Science and Engineering, Loyola Marymount University, Los Angeles, CA, United States. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260717 PL - Canada TA - JMIR Hum Factors JT - JMIR human factors JID - 101666561 SB - IM MH - Humans MH - *Mobile Applications/standards/statistics & numerical data MH - Female MH - Male MH - Young Adult MH - *Feeding Behavior MH - Adult MH - Students MH - Adolescent MH - *Diet/standards MH - *Smartphone PMC - PMC13428206 OTO - NOTNLM OT - college age OT - disordered eating OT - intuitive eating OT - mobile app OT - natural language processing OT - nutrition OT - physical activity OT - recipes OT - recommendations COIS- Conflicts of Interest: MK is the owner of MealMate Inc. All other authors declare no other conflicts of interest. EDAT- 2026/07/17 19:17 MHDA- 2026/07/17 19:18 PMCR- 2026/07/17 CRDT- 2026/07/17 16:54 PHST- 2025/07/30 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/17 19:18 [medline] PHST- 2026/07/17 19:17 [pubmed] PHST- 2026/07/17 16:54 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - v13i1e81439 [pii] AID - 10.2196/81439 [doi] PST - epublish SO - JMIR Hum Factors. 2026 Jul 17;13:e81439. doi: 10.2196/81439. PMID- 42467841 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260914 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 Jul 17 TI - mHealth Technologies for the Care of Children With Congenital Heart Disease: Scoping Review. PG - e83385 LID - 10.2196/83385 [doi] LID - e83385 AB - BACKGROUND: Mobile information technology (IT) is increasingly being used in the health care sector, and it can play a critical role in both the care of children with congenital heart disease (CHD) and the quality of life of their families. OBJECTIVE: This study aimed to conduct a scoping review of the application of mobile health (mHealth) technologies in the care of children with CHD. We summarized the forms of mHealth interventions and effects on CHD to provide a reference for future research in this field. METHODS: We searched PubMed; Embase; Web of Science; the Cochrane Library; CINAHL; China National Knowledge Infrastructure; Wanfang Data; the Chinese Biomedical Database; VIP Chinese Science and Technology Journal Database; National Guideline Clearinghouse of the United States; the website of the Registered Nurses' Association of Ontario, Canada; the Guidelines International Network; the American Heart Association; and the American Association of Cardiovascular and Pulmonary Rehabilitation. The search period was from the establishment of the databases to June 12, 2025. The retrieved literature was screened and analyzed. RESULTS: A total of 519 Chinese- and English-language articles were identified, with 44 (8.5%) studies meeting the inclusion criteria. The primary forms of mHealth interventions for patients with CHD included mobile apps, wearable devices, and remote monitoring equipment. The findings indicated that mHealth technologies could improve exercise capacity, nutritional status, psychological well-being, and quality of life in children with CHD. CONCLUSIONS: The application of mHealth in the care of children with CHD is feasible and demonstrates positive effects. Future research should emphasize peer education and patient privacy protection while further exploring remote education and health management based on theoretical frameworks and intelligent ITs to enhance quality of life for both children with CHD and their parents. CI - (c) Mingzhu Wang, Qiuyin Pan, Shengrong Tan, Yuanchun Kong, Zhengling Dai, Jiao Cai, Duoqin Bi, Jiali Zhou. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Wang, Mingzhu AU - Wang M AUID- ORCID: 0009-0008-8207-3049 AD - Children's Heart Center, Guizhou Branch of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Guizhou Hospital, Guiyang, Guizhou, China, 86 13601626175. FAU - Pan, Qiuyin AU - Pan Q AUID- ORCID: 0000-0002-8697-1486 AD - Children's Heart Center, Guizhou Branch of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Guizhou Hospital, Guiyang, Guizhou, China, 86 13601626175. FAU - Tan, Shengrong AU - Tan S AUID- ORCID: 0009-0007-3228-7113 AD - Children's Heart Center, Guizhou Branch of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Guizhou Hospital, Guiyang, Guizhou, China, 86 13601626175. FAU - Kong, Yuanchun AU - Kong Y AUID- ORCID: 0009-0006-0254-6471 AD - Children's Heart Center, Guizhou Branch of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Guizhou Hospital, Guiyang, Guizhou, China, 86 13601626175. FAU - Dai, Zhengling AU - Dai Z AUID- ORCID: 0009-0007-6942-6535 AD - Children's Heart Center, Guizhou Branch of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Guizhou Hospital, Guiyang, Guizhou, China, 86 13601626175. FAU - Cai, Jiao AU - Cai J AUID- ORCID: 0009-0008-5389-8148 AD - Children's Heart Center, Guizhou Branch of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Guizhou Hospital, Guiyang, Guizhou, China, 86 13601626175. FAU - Bi, Duoqin AU - Bi D AUID- ORCID: 0009-0008-1485-8119 AD - Children's Heart Center, Guizhou Branch of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Guizhou Hospital, Guiyang, Guizhou, China, 86 13601626175. FAU - Zhou, Jiali AU - Zhou J AUID- ORCID: 0000-0002-5055-9537 AD - Children's Heart Center, Guizhou Branch of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Guizhou Hospital, Guiyang, Guizhou, China, 86 13601626175. AD - Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Scoping Review DEP - 20260717 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - *Heart Defects, Congenital/psychology/therapy MH - *Telemedicine/standards/instrumentation/trends MH - Child MH - Digital Health MH - Mobile Applications/standards MH - Quality of Life/psychology PMC - PMC13379060 OTO - NOTNLM OT - congenital heart disease OT - mobile health OT - pediatric OT - scoping review OT - telemedicine COIS- Conflicts of Interest: None declared. EDAT- 2026/07/17 19:17 MHDA- 2026/07/17 19:18 PMCR- 2026/07/17 CRDT- 2026/07/17 15:23 PHST- 2025/09/02 00:00 [received] PHST- 2026/04/19 00:00 [revised] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/07/17 19:18 [medline] PHST- 2026/07/17 19:17 [pubmed] PHST- 2026/07/17 15:23 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - v14i1e83385 [pii] AID - 83385 [pii] AID - 10.2196/83385 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Jul 17;14:e83385. doi: 10.2196/83385. PMID- 42467727 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Applying Brazilian front-of-pack nutrition labeling and PAHO nutritional criteria to digital food advertising: regulatory implications for protecting children and adolescents. PG - e0354180 LID - 10.1371/journal.pone.0354180 [doi] LID - e0354180 AB - Front-of-pack nutrition labeling (FoPNL) and restrictions on food advertising are regulatory strategies to support informed dietary choices and reduce exposure to unhealthy food. These measures are often integrated through a policy package, that employs a Nutrient Profile Model (NPM) for the classification of food. In Brazil, however, these policies remain fragmented, and current food advertising regulations do not fully cover all channels, particularly digital media. This study applied the NPM adopted in Brazil's FoPNL (RDC No. 429/2020 in conjunction with IN No. 75/2020, hereafter RDC 429) and those proposed by the Pan American Health Organization (PAHO) for identifying foods subject to advertising restrictions on social media posts directed at children and adolescents. The sample included posts from ultra-processed food brands/products on Instagram (n = 623), TikTok (n = 257), and YouTube (n = 114). Both NPM were applied to assess non-compliance at the food-item level and at the advertisement level (considering posts containing at least one non-compliant food). At the food-item level, 61.28% of products exceeded at least one item of RDC 429, with the highest prevalence on TikTok (72.63%), while 93.86% were non-compliant according to PAHO, reaching 100% on TikTok and 98.5% on YouTube. At the advertisement level, 49.53% of posts contained at least one non-compliant food under RDC 429, and 74.13% under PAHO, with YouTube showing the greatest potential for restriction (62.16% RDC; 99.10% PAHO). Both models are feasible for regulating digital food advertising: the PAHO provides a robust framework, while RDC 429 offers a strategic starting point given its current implementation in Brazil. CI - Copyright: (c) 2026 Matos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Matos, Juliana de Paula AU - Matos JP AUID- ORCID: 0000-0002-1424-8344 AD - Department of Nutrition, School of Nursing, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. FAU - Araujo, Breenda Lorranny Santos Goncalves AU - Araujo BLSG AD - Department of Nutrition, School of Nursing, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. FAU - Ribeiro, Mariana AU - Ribeiro M AD - Center for Epidemiological Research in Nutrition and Health (Nupens), University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil. AD - Brazilian Institute for Consumer Defense, Sao Paulo, Sao Paulo, Brazil. FAU - Mais, Lais Amaral AU - Mais LA AD - Brazilian Institute for Consumer Defense, Sao Paulo, Sao Paulo, Brazil. FAU - Horta, Paula Martins AU - Horta PM AUID- ORCID: 0000-0002-1848-6470 AD - Department of Nutrition, School of Nursing, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. LA - eng PT - Journal Article DEP - 20260717 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Brazil MH - Humans MH - *Advertising/legislation & jurisprudence MH - *Food Labeling/legislation & jurisprudence MH - Adolescent MH - Child MH - Digital Media MH - Nutritive Value MH - *Nutrition Policy/legislation & jurisprudence MH - Social Media PMC - PMC13379089 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/17 19:17 MHDA- 2026/07/17 19:18 PMCR- 2026/07/17 CRDT- 2026/07/17 13:54 PHST- 2025/12/01 00:00 [received] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/07/17 19:18 [medline] PHST- 2026/07/17 19:17 [pubmed] PHST- 2026/07/17 13:54 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - PONE-D-25-63833 [pii] AID - 10.1371/journal.pone.0354180 [doi] PST - epublish SO - PLoS One. 2026 Jul 17;21(7):e0354180. doi: 10.1371/journal.pone.0354180. eCollection 2026. PMID- 42467570 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260813 IS - 1469-0705 (Electronic) IS - 0960-7692 (Print) IS - 0960-7692 (Linking) VI - 68 IP - 2 DP - 2026 Aug TI - Development and external validation of prognostic markers to predict pump-twin survival in twin reversed arterial perfusion sequence. PG - 220-228 LID - 10.1002/uog.70256 [doi] AB - OBJECTIVES: To evaluate the outcome of monochorionic diamniotic (MCDA) pregnancies complicated by twin reversed arterial perfusion (TRAP) sequence and to evaluate potential prognostic ultrasound markers as predictors of pump-twin survival. METHODS: This was a retrospective cohort study of MCDA twin pregnancies diagnosed with TRAP sequence at two medical centers in China between January 2010 and December 2024. All cases were analyzed retrospectively for intrauterine course and outcome. Cases that underwent expectant management were assigned to the primary cohort (cases from the First Affiliated Hospital of Sun Yat-sen University, Guangzhou) or the external-validation cohort (cases from Dalian Women and Children's Medical Group, Dalian). Cases that underwent intrauterine intervention at the First Affiliated Hospital of Sun Yat-sen University were assigned to the intrauterine-intervention cohort. The following parameters were evaluated in the primary and external-validation cohorts for their predictive value regarding pump-twin survival: in the first trimester, the crown-rump length (CRL) and nuchal translucency thickness of the pump twin, the upper pole-rump length (URL) of the acardiac twin, the URL/CRL ratio, and the presence of reversed a-wave in the ductus venosus and the umbilical artery pulsatility index (UA-PI) in the acardiac twin; and in the second trimester, the URL of the acardiac twin, the estimated fetal weight (EFW) of each twin, the twin weight ratio (TWR) (EFW(acardiac twin)/EFW(pump twin)) and the UA-PI of each twin. Univariate Cox regression analysis was performed to identify the parameters associated with pump-twin survival. Performance was evaluated by the area under the receiver-operating-characteristics curves (AUCs) and calibration curves. Finally, Kaplan-Meier survival analysis was performed. RESULTS: A total of 117 MCDA pregnancies with TRAP sequence were included in the analysis: 55 in the primary cohort, 38 in the intrauterine-intervention cohort and 24 in the external-validation cohort. The overall pump-twin survival rate was 65.8% (77/117). Three variables (URL and URL/CRL ratio in the first trimester and TWR in the second trimester) were identified to be independent risk factors influencing pump-twin survival in both the primary and external-validation cohorts. The AUCs were indicative of good predictive discrimination in both cohorts: 0.811 (95% CI, 0.667-0.956) for URL, 0.780 (95% CI, 0.619-0.941) for the URL/CRL ratio and 0.859 (95% CI, 0.730-0.988) for TWR in the primary cohort; and 0.844 (95% CI, 0.662-1.000) for URL, 0.823 (0.633-1.000) for the URL/CRL ratio and 0.925 (95% CI, 0.766-1.000) for TWR in the external-validation cohort. The optimal cut-off values were 4.85 cm for URL, 0.54 for the URL/CRL ratio and 0.295 for TWR in the primary cohort. The TWR exhibited good calibration, but URL and the URL/CRL ratio exhibited poor calibration. Kaplan-Meier survival analysis revealed that pump twins with TWR >/= 0.295 experienced a significantly shorter intrauterine survival duration in both the primary and external-validation cohorts, and pump twins with URL >/= 4.85 cm or URL/CRL ratio >/= 0.54 experienced a significantly shorter intrauterine survival duration in the primary cohort. However, the optimal cut-offs of URL and the URL/CRL ratio showed no statistical difference in the external-validation cohort. CONCLUSION: After 14 + 0 weeks' gestation, the threshold of TWR < 0.295 can reliably predict survival of the pump twin in MCDA pregnancies with TRAP sequence. However, the predictive value of URL and the URL/CRL ratio in the first trimester for pump-twin survival is poor. A well-designed prospective multicenter study is warranted to develop a first-trimester multivariable predictive model with enhanced predictive performance. (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. FAU - Wu, L-H AU - Wu LH AUID- ORCID: 0000-0003-0354-3396 AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Yang, Y-Y AU - Yang YY AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Shen, H AU - Shen H AUID- ORCID: 0000-0002-9576-2619 AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Du, L AU - Du L AUID- ORCID: 0000-0001-5049-2267 AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Liu, Y AU - Liu Y AD - Department of Ultrasound, Dalian Women and Children's Medical Group, Dalian, China. FAU - Peng, R AU - Peng R AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Xie, H-N AU - Xie HN AUID- ORCID: 0000-0002-1705-1328 AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260717 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - Prognosis MH - *Pregnancy, Twin MH - *Ultrasonography, Prenatal MH - *Fetofetal Transfusion/diagnostic imaging/mortality MH - Crown-Rump Length MH - Predictive Value of Tests MH - China MH - Adult MH - Nuchal Translucency Measurement MH - Pregnancy Outcome MH - Umbilical Arteries/diagnostic imaging/embryology PMC - PMC13432978 OTO - NOTNLM OT - TRAP sequence OT - prognostic predictors OT - pump-twin survival OT - twin reversed arterial perfusion sequence OT - ultrasound EDAT- 2026/07/17 19:17 MHDA- 2026/08/03 18:37 PMCR- 2026/08/03 CRDT- 2026/07/17 13:03 PHST- 2026/01/28 00:00 [revised] PHST- 2025/11/05 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/08/03 18:37 [medline] PHST- 2026/07/17 19:17 [pubmed] PHST- 2026/07/17 13:03 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - UOG70256 [pii] AID - 10.1002/uog.70256 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2026 Aug;68(2):220-228. doi: 10.1002/uog.70256. Epub 2026 Jul 17. PMID- 42464896 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Feasibility and Readiness for Scaling-Up Multiple Micronutrient Supplements in Nepal: A Qualitative Study Using the Expandnet Scaling-Up Framework. PG - e70231 LID - 10.1111/mcn.70231 [doi] LID - e70231 AB - Micronutrient deficiencies in pregnancy remain a critical public health issue in Nepal, where iron-folic acid (IFA) supplementation alone has not fully addressed maternal and neonatal risks. Multiple micronutrient supplements (MMS) promise broader nutritional benefits; however, real-world guidance for their effective and equitable integration into routine maternal care is lacking. A qualitative study, guided by the ExpandNet scaling-up framework, was conducted from February to March 2025, including 28 focus group discussions with antenatal care (ANC) providers and female community health volunteers (FCHVs) and 40 key informant interviews with policymakers at different levels of the health system. Data was analyzed thematically to identify perceived facilitators and barriers to MMS adoption, institutionalization, and scale-up, and equitable implementation. Stakeholders viewed MMS as offering clear advantages over IFA, citing broader micronutrient coverage and fewer side effects that could improve adherence. However, they identified several system-level requirements for successful scale-up, including formal policy integration, sustainable financing, strengthened procurement and supply chains, and adequate storage capacity at facilities. FCHVs and ANC providers emphasized the need for clearer role definitions, improved training, and manageable counseling workloads. Persistent community-level barriers-such as concerns about tablet size, misconceptions about fetal growth, and low trust in free medicines-were seen as risks to equitable uptake. Respondents highlighted community engagement, culturally tailored counseling, and consistent support for FCHVs and ANC providers as essential to ensuring effective and equitable MMS adoption. Stakeholders in Nepal view MMS as a promising strategy to improve maternal and newborn nutrition, but its potential depends on strong policy commitment, adequate and sustainable financing, and community-centered implementation. Addressing product-related concerns, strengthening counseling and trust in public services, and ensuring uninterrupted supply chains are essential to MMS scale-up, including translating its introduction into equitable and meaningful gains in maternal and child nutrition. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Hoang, Mai-Anh AU - Hoang MA AD - Helen Keller Intl, New York, New York, USA. FAU - Joshi, Nira AU - Joshi N AD - New ERA, Kathmandu, Bagmati, Nepal. FAU - Cunningham, Kenda AU - Cunningham K AD - Helen Keller Intl, New York, New York, USA. AD - International Food Policy Research Institute, London, UK. FAU - Singh, Usha AU - Singh U AD - New ERA, Kathmandu, Bagmati, Nepal. FAU - Lal, Bibek Kumar AU - Lal BK AD - Family Welfare Division, Ministry of Health and Food Safety, Kathmandu, Bagmati, Nepal. FAU - Thapa, Lila Bikram AU - Thapa LB AD - Family Welfare Division, Ministry of Health and Food Safety, Kathmandu, Bagmati, Nepal. FAU - Pandey, Pooja AU - Pandey P AD - Helen Keller Intl, Kathmandu, Bagmati, Nepal. FAU - Klemm, Rolf AU - Klemm R AD - Helen Keller Intl, New York, New York, USA. AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Rana, Yashodhara AU - Rana Y AD - Eleanor Crook Foundation, Washington, D.C., USA. FAU - Pokhrel, Sudip AU - Pokhrel S AD - Eleanor Crook Foundation, Washington, D.C., USA. FAU - Poudel, Sasmita AU - Poudel S AD - Helen Keller Intl, Kathmandu, Bagmati, Nepal. LA - eng GR - 66677/Eleanor Crook Foundation/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 RN - 0 (Micronutrients) RN - 935E97BOY8 (Folic Acid) SB - IM MH - Humans MH - *Micronutrients/administration & dosage/deficiency MH - Nepal MH - *Dietary Supplements MH - Female MH - Pregnancy MH - *Prenatal Care/methods MH - Qualitative Research MH - Focus Groups MH - Feasibility Studies MH - Adult MH - Folic Acid/administration & dosage PMC - PMC13377524 OTO - NOTNLM OT - ExpandNet OT - Nepal OT - antenatal care OT - implementation science OT - maternal nutrition OT - multiple micronutrient supplementation OT - qualitative research OT - scale-up COIS- YR and SPo, who are employed by Eleanor Crook Foundation, provided technical guidance on study design and data collection. NJ, US, and KC report a relationship with Helen Keller Intl that includes consulting support and travel reimbursement. All other authors report no conflicts of interest. EDAT- 2026/07/17 17:25 MHDA- 2026/07/17 17:26 PMCR- 2026/07/17 CRDT- 2026/07/17 06:13 PHST- 2026/06/02 00:00 [revised] PHST- 2026/03/23 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/17 17:26 [medline] PHST- 2026/07/17 17:25 [pubmed] PHST- 2026/07/17 06:13 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - MCN70231 [pii] AID - 10.1111/mcn.70231 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70231. doi: 10.1111/mcn.70231. PMID- 42464825 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260717 IS - 2239-253X (Electronic) IS - 0003-469X (Linking) VI - 97 IP - 7 DP - 2026 Jul 14 TI - Preoperative Inflammatory and Nutritional Indices as Predictors of Infectious Complications Following Elective Cesarean Section in Patients With Gestational Diabetes Mellitus: A Retrospective Study. PG - 1292-1299 LID - 10.62713/aic.4544 [doi] AB - AIM: Postoperative infection is a significant complication that may adversely affect maternal recovery following cesarean section. Patients with gestational diabetes mellitus (GDM) may be at increased risk due to metabolic dysregulation and altered immune function. This study aimed to investigate preoperative risk factors for infectious complications following elective cesarean section in patients with GDM, with a focus on readily obtainable inflammatory and nutritional indices. METHODS: This retrospective study included 383 patients with GDM who underwent elective cesarean section at Tongxiang Maternity and Child Health Care Hospital between January 2022 and February 2025. Preoperative inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP), as well as nutritional indices, including prognostic nutritional index (PNI) and hemoglobin (Hb), were collected. Univariate and multivariate logistic regression analyses were performed to identify risk factors for postoperative infection, and a risk stratification approach based on inflammatory and nutritional indices was developed. RESULTS: Among the 383 patients, 72 (18.8%) developed postoperative infections. Multivariable analysis identified elevated CRP (odds ratio (OR) = 2.383, 95% confidence interval (CI): 1.669-4.427), decreased PNI (OR = 0.680, 95% CI: 0.507-0.842), decreased hemoglobin (OR = 0.854, 95% CI: 0.746-0.945), and elevated PLR (OR = 1.046, 95% CI: 1.006-1.101) as independent risk factors for postoperative infection (all p < 0.05). Receiver operating characteristic (ROC) analysis demonstrated good discriminative performance of the inflammatory and nutritional indices, with CRP showing the strongest performance. Risk stratification based on the number of these factors (CRP, PLR, PNI, Hb) showed infection rates of 0.0%, 1.4%, 14.1%, 84.2%, and 100.0% for patients with 0, 1, 2, 3, and 4 factors, respectively (trend test p < 0.001). CONCLUSIONS: Preoperative elevation of inflammatory markers (CRP, PLR) and impairment of nutritional status (PNI, Hb) are independent risk factors for post-cesarean infection in patients with GDM. Preoperative risk assessment incorporating these indices may facilitate identification of high-risk patients and support targeted perioperative management strategies. CI - (c) Copyright: (c) 2026 The Author(s). FAU - Zhang, Xiaoli AU - Zhang X AD - Department of Obstetrics, Tongxiang Maternity and Child Health Care Hospital, 314500 Jiaxing, Zhejiang, China. FAU - Chen, Chen AU - Chen C AD - Department of Obstetrics, Tongxiang Maternity and Child Health Care Hospital, 314500 Jiaxing, Zhejiang, China. LA - eng PT - Journal Article PL - Italy TA - Ann Ital Chir JT - Annali italiani di chirurgia JID - 0372343 RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - Pregnancy MH - *Diabetes, Gestational/blood MH - *Cesarean Section/adverse effects MH - Adult MH - Risk Factors MH - C-Reactive Protein/analysis MH - Elective Surgical Procedures MH - *Postoperative Complications/epidemiology/etiology MH - *Inflammation/blood MH - *Nutrition Assessment MH - *Nutritional Status MH - Preoperative Period OTO - NOTNLM OT - cesarean section OT - gestational diabetes mellitus OT - inflammatory indices OT - nutritional status OT - postoperative infection COIS- The authors declare no conflict of interest. EDAT- 2026/07/17 06:44 MHDA- 2026/07/17 12:41 CRDT- 2026/07/17 05:16 PHST- 2026/01/12 00:00 [received] PHST- 2026/02/06 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/07/17 12:41 [medline] PHST- 2026/07/17 06:44 [pubmed] PHST- 2026/07/17 05:16 [entrez] AID - S0003-469X(26)00136-0 [pii] AID - 10.62713/aic.4544 [doi] PST - ppublish SO - Ann Ital Chir. 2026 Jul 14;97(7):1292-1299. doi: 10.62713/aic.4544. PMID- 42464261 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1465-993X (Electronic) IS - 1465-9921 (Print) IS - 1465-9921 (Linking) VI - 27 IP - 1 DP - 2026 Jul 17 TI - Aspartame and asthma: immunomodulatory effects on airway inflammation. LID - 10.1186/s12931-026-03820-1 [doi] LID - 393 AB - BACKGROUND AND OBJECTIVE: Asthma is a heterogeneous inflammatory airway disease influenced by genetic and environmental factors, including diet. Aspartame, a widely used artificial sweetener, has been implicated in immunometabolic changes that may affect asthma risk, but the potential role evidence remains limited. We aimed to examine the association between aspartame intake and asthma outcomes using integrated human analyses and complementary animal experiments. METHODS: Human data were obtained from 1021 adolescents in the Taiwan Puberty Longitudinal Study. Aspartame consumption, assessed using a validated food frequency questionnaire, was categorized as none, low, or high based on median intake. Asthma status was determined based on physician diagnosis and symptom history. In parallel, BALB/c mice were sensitized with house dust mite (HDM) extract and administered oral aspartame at 15, 30, or 60 mg/kg/day for 10 weeks. Immunological, microbiome, metabolic, and histopathological parameters were evaluated. RESULTS: Low aspartame consumption was significantly associated with higher odds of asthma (odds ratio = 2.852; 95% confidence interval: 1.038-8.014; p = 0.0369). In mice, aspartame exposure increased serum IgE levels, airway inflammation, and MMP-12 and MCP-1 expression. Although lung function changes were not statistically significant, histological analyses revealed more pronounced goblet cell hyperplasia, peribronchial collagen deposition, and eosinophilic infiltration, especially in the 60 mg/kg group. Aspartame also reduced microbial alpha-diversity and altered microbial composition. Short-chain fatty acids profiling revealed significantly decreased isobutyric, hexanoic, and heptanoic acid levels in aspartame-treated mice. CONCLUSIONS: Aspartame intake exacerbates asthma-related immunological, microbial, and histological disturbances. CI - (c) 2026. The Author(s). FAU - Utami, Fasty Arum AU - Utami FA AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, 110, Taiwan. AD - Department of Nutrition and Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia. FAU - Huang, Shih-Yi AU - Huang SY AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, 110, Taiwan. FAU - Liu, Yu-Hsiang AU - Liu YH AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Hsu, Jhih-Wei AU - Hsu JW AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Mazariegos, Jose Roberto Rodriguez AU - Mazariegos JRR AD - College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. AD - Faculty of Health Sciences, Rafael Landivar University, Guatemala City, 01016, Guatemala. FAU - Nguyen, Nam Nhat AU - Nguyen NN AD - Endocrinology Clinic, Hanh Phuc International Hospital, Ho Chi Minh City, 700000, Vietnam. FAU - Huang, Shiu-Wen AU - Huang SW AD - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. AD - Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Weng, Chih-Ming AU - Weng CM AD - School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Chuang, Hsiao-Chi AU - Chuang HC AD - School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Huang, Chung-Hsiung AU - Huang CH AD - Department of Food Science, National Taiwan Ocean University, Keelung, 202301, Taiwan. FAU - Tsai, Wan-Ling AU - Tsai WL AD - School of Nursing, College of Nursing, Fooyin University, Kaohsiung, 831, Taiwan. FAU - Chen, Yang-Ching AU - Chen YC AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, 11696, Taiwan. melisa26@tmu.edu.tw. AD - Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Child Development Research Center, Taipei Medical University Hospital, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. LA - eng GR - 113-2628-B-038-006-MY3/National Science and Technology Council/ GR - 112TMU-TMUH-02-1 and 113TMU-TMUH-01/Taipei Medical University Hospital/ PT - Journal Article DEP - 20260717 PL - England TA - Respir Res JT - Respiratory research JID - 101090633 RN - Z0H242BBR1 (Aspartame) RN - 0 (Sweetening Agents) SB - IM MH - Animals MH - *Asthma/immunology/chemically induced/epidemiology/metabolism MH - Humans MH - *Aspartame/administration & dosage/adverse effects MH - Adolescent MH - Male MH - Female MH - Mice, Inbred BALB C MH - Mice MH - Longitudinal Studies MH - Taiwan/epidemiology MH - *Lung/drug effects/immunology/metabolism MH - *Sweetening Agents/administration & dosage/adverse effects MH - Dose-Response Relationship, Drug PMC - PMC13656438 OTO - NOTNLM OT - Airway Inflammation OT - Aspartame OT - Asthma OT - Microbiota OT - Non-nutritive Sweeteners OT - Short-chain fatty acids COIS- Declarations. Ethics approval and consent to participate: The human study protocol was approved by the Institutional Review Board of Taipei Medical University (N202203060) and conducted according to the Declaration of Helsinki. Written informed consent was obtained from both parents/guardians and participating children. Animal procedures were approved by the Taipei Medical University IACUC (LAC2022-0241, LAC2023-0236) and complied with institutional and international animal care guidelines. Consent for publication: Written informed consent for publication of the study data, including any potentially identifiable information, was obtained from all participating children and their parents or legal guardians. Competing interests: The authors declare no competing interests. EDAT- 2026/07/17 06:44 MHDA- 2026/10/12 05:32 PMCR- 2026/07/17 CRDT- 2026/07/17 00:51 PHST- 2025/10/30 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/10/12 05:32 [medline] PHST- 2026/07/17 06:44 [pubmed] PHST- 2026/07/17 00:51 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.1186/s12931-026-03820-1 [pii] AID - 3820 [pii] AID - 10.1186/s12931-026-03820-1 [doi] PST - epublish SO - Respir Res. 2026 Jul 17;27(1):393. doi: 10.1186/s12931-026-03820-1. PMID- 42464168 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20260930 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jul 16 TI - Differences in fetal soft tissue thickness between GDM and non-GDM pregnancies and an exploratory nomogram for LGA prediction. LID - 10.1186/s12884-026-09665-2 [doi] LID - 1073 AB - BACKGROUND: This study aimed to compare fetal soft tissue thickness, particularly anterior abdominal wall thickness (AAWT), between GDM and non-GDM pregnancies, and to preliminarily explore its association with LGA as a secondary analysis. METHODS: A retrospective analysis was conducted on 250 pregnant women who underwent regular prenatal examinations at our hospital from January 2021 to February 2022, consisting of 125 cases in the GDM group and 125 in the non-GDM group. Ultrasound measurements of conventional fetal biometric parameters (biparietal diameter [BPD], head circumference [HC], abdominal circumference [AC], and femur length [FL]) and AAWT, fetal thigh soft tissue thickness [FTSTT], thigh muscle thickness [TM], and thigh fat thickness [TF]) were performed at 24-26, 30-32, and 36-38 weeks of gestation. Differences between the two groups were compared. Correlations between each indicator and birth weight were analyzed, along with their individual predictive efficacy for LGA. Predictor variables were selected using univariate and multivariate logistic regression as well as LASSO regression to construct an LGA risk prediction model. Its performance was compared with a estimated fetal weight (EFW) prediction model. Finally, a nomogram was developed for visual prediction. RESULTS: Maternal age, pre-pregnancy BMI, and neonatal birth weight were significantly higher in the GDM group than in the non-GDM group (P < 0.05). Fetal AAWT was also significantly greater in the GDM group across all measured gestational periods (P < 0.05). In LGA fetuses, AAWT and AC, and other parameters were significantly larger than in non-LGA fetuses at all gestational weeks (P < 0.05). Among all indicators, AAWT exhibited the strongest correlation with birth weight, and this correlation strengthened with advancing gestation (r = 0.666 at 36-38 weeks). ROC curve analysis showed that AAWT at 36-38 weeks had the highest predictive efficacy for LGA (AUC = 0.940). The multivariate logistic regression model identified AAWT at 30-32 weeks, AAWT at 36-38 weeks, and AC as independent predictors of LGA. The logistic regression model constructed based on these factors demonstrated good predictive performance (AUC = 0.966) and outperformed the EFW prediction model. Based on this model, a clinically practical nomogram was subsequently established. CONCLUSIONS: Fetal AAWT is significantly greater in GDM pregnancies than in non-GDM pregnancies and is strongly associated with LGA. A preliminary exploratory model incorporating AAWT and AC demonstrated potential utility in identifying LGA, but these findings require validation in larger, LGA-enriched cohorts. The nomogram should be considered hypothesis-generating rather than ready for clinical implementation. CI - (c) 2026. The Author(s). FAU - Zeng, Qiaoli AU - Zeng Q AD - Department of Internal Medicine, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. AD - Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, Guangdong, China. AD - Maternal and Child Research Institute, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Hu, Chunyan AU - Hu C AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Liang, Yuqiao AU - Liang Y AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Liu, Jiaxin AU - Liu J AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Chen, Yixing AU - Chen Y AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Zhao, Dan AU - Zhao D AD - Department of Obstetrics and Gynecology, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Wei, Yue AU - Wei Y AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. weiyue138@163.com. FAU - Guo, Runmin AU - Guo R AD - Department of Internal Medicine, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. runmin.guo@gdmu.edu.cn. AD - Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, Guangdong, China. runmin.guo@gdmu.edu.cn. AD - Maternal and Child Research Institute, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. runmin.guo@gdmu.edu.cn. LA - eng GR - 2520001002619/Self-financing science and technology project of Foshan/ GR - 2420001004539/Self-financing science and technology project of Foshan/ PT - Journal Article DEP - 20260716 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Nomograms MH - Retrospective Studies MH - Infant, Large for Gestational Age MH - Ultrasonography, Prenatal MH - Adult MH - *Diabetes, Gestational MH - *Abdominal Wall/diagnostic imaging/embryology MH - *Fetus/diagnostic imaging MH - *Fetal Macrosomia MH - Fetal Weight PMC - PMC13617886 OTO - NOTNLM OT - Fetal Anterior Abdominal Wall Thickness OT - Gestational Diabetes Mellitus OT - Large for Gestational Age OT - Logistic Regression Model OT - Nomogram OT - Ultrasonography COIS- Declarations. Ethics approval and consent to participate: The studies involving humans were approved by Ethics Committee of Shunde Women and Children's Hospital of Guangdong Medical University (Maternity and Child Healthcare Hospital of Shunde Foshan) (KY-2025-071-1); in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/17 06:44 MHDA- 2026/09/29 06:25 PMCR- 2026/07/16 CRDT- 2026/07/17 00:47 PHST- 2026/01/28 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/09/29 06:25 [medline] PHST- 2026/07/17 06:44 [pubmed] PHST- 2026/07/17 00:47 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - 10.1186/s12884-026-09665-2 [pii] AID - 9665 [pii] AID - 10.1186/s12884-026-09665-2 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jul 16;26(1):1073. doi: 10.1186/s12884-026-09665-2. PMID- 42463960 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260717 LR - 20260926 IS - 2731-4251 (Electronic) IS - 2731-4251 (Linking) VI - 5 IP - 1 DP - 2026 Jul 16 TI - Mendelian randomization of risk factors for premenstrual disorders. LID - 10.1038/s44184-026-00231-4 [doi] LID - 35 AB - The causal role of established risk factors for premenstrual disorders (PMDs) remains unclear. We used Mendelian randomization (MR) to assess causality for eight known-risk factors identified through a literature review. Summary statistics for these risk factors were from genome-wide association studies (GWAS) with sample size ranging from 129,017 to 1.2 million, and for PMDs from a GWAS of 72,297 participants. Findings were validated using one-sample MR in LifeGene cohort (n = 5674-5937). In two-sample MR, genetic liability to smoking initiation (OR = 1.25 (1.10-1.43)), earlier menarche (OR = 0.94 (0.89-0.98) per year), and higher BMI (OR = 1.19 (1.05-1.34) per kg/m(2)) were associated with PMD risk. No causal association was indicated for anemia, childhood abuse, childhood asthma, diabetes, and endometriosis. In one-sample MR, point estimates for BMI (OR = 1.10 (0.88-1.38) per kg/m(2)) and earlier menarche (OR = 0.98 (0.83-1.15) per year) were directionally consistent with the two-sample MR findings, but the confidence intervals included null effects. However, a null association was observed for smoking (OR = 0.94 (0.77-1.16)). The two-sample MR supports causal role of earlier menarche, higher BMI, and smoking in risk of PMDs. The lack of replication in one-sample MR highlights the need for triangulating evidence from future well-powered and methodologically comparable studies to strengthen these findings. CI - (c) 2026. The Author(s). FAU - Yang, Yihui AU - Yang Y AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. yihui.yang.2@ki.se. FAU - Tang, Bowen AU - Tang B AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Hysaj, Elgeta AU - Hysaj E AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Xiang, Nanyan AU - Xiang N AD - Health Management Center, General Practice Medical Center, Lab of Health Data Science, Innovation Institute for Integration of Medicine and Engineering, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Qu, Susu AU - Qu S AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Hagg, Sara AU - Hagg S AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Valdimarsdottir, Unnur A AU - Valdimarsdottir UA AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. AD - Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland. AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Bertone-Johnson, Elizabeth AU - Bertone-Johnson E AD - Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA. AD - Department of Health Promotion and Policy, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA. FAU - Lu, Yi AU - Lu Y AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Lu, Donghao AU - Lu D AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. donghao.lu@ki.se. LA - eng PT - Journal Article DEP - 20260716 PL - England TA - Npj Ment Health Res JT - Npj mental health research JID - 9918592488906676 PMC - PMC13376395 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/07/17 04:03 MHDA- 2026/07/17 04:04 PMCR- 2026/07/16 CRDT- 2026/07/16 23:48 PHST- 2026/02/23 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/17 04:04 [medline] PHST- 2026/07/17 04:03 [pubmed] PHST- 2026/07/16 23:48 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - 10.1038/s44184-026-00231-4 [pii] AID - 231 [pii] AID - 10.1038/s44184-026-00231-4 [doi] PST - epublish SO - Npj Ment Health Res. 2026 Jul 16;5(1):35. doi: 10.1038/s44184-026-00231-4. PMID- 42463441 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1096-9888 (Electronic) IS - 1076-5174 (Print) IS - 1076-5174 (Linking) VI - 61 IP - 8 DP - 2026 Aug TI - Green and Rapid Determination of Phthalates in Mineral Water From Virgin and Recycled PET Bottles. PG - e70089 LID - 10.1002/jms.70089 [doi] LID - e70089 AB - This study investigates the presence and quantification of phthalates released into mineral waters from virgin and recycled polyethylene terephthalate (PET) bottles. A green, solvent-free analytical method based on solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC/MS) was developed and validated to detect the following four target phthalates: diethyl phthalate (DEP), diisobutyl phthalate (DiBP), dibutyl phthalate (DBP), and bis(2-ethylhexyl) phthalate (DEHP). The analytical method showed good sensitivity, precision, accuracy, and low limits of detection and quantification. Seventeen commercial water samples were analyzed, including 11 from virgin PET and six from recycled PET bottles with varying recycling content (30%-100%). Phthalate concentrations ranged from 2.21 to 18.96 mug/L, with DEHP being the most prevalent compound. Risk assessment following EFSA guidelines demonstrated that the estimated daily intakes (DIs) and the risk quotient (RQ) of all detected phthalates were well below the tolerable DI limits for both adults and toddlers. These findings confirm that the proposed method is suitable for routine screening of phthalates in mineral water and highlight the need for stricter quality controls in the recycled PET supply chain. CI - (c) 2026 The Author(s). Journal of Mass Spectrometry published by John Wiley & Sons Ltd. FAU - Lino, Claudia AU - Lino C AUID- ORCID: 0000-0002-8724-7772 AD - Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy. FAU - Indelicato, Serena AU - Indelicato S AD - Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy. FAU - Bongiorno, David AU - Bongiorno D AUID- ORCID: 0000-0002-9856-356X AD - Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy. FAU - D'Agostino, Fabio AU - D'Agostino F AD - Institute of Anthropic Impacts and Sustainability in the Marine Environment (IAS), National Research Council of Italy (IAS-CNR), Trapani, Italy. FAU - Avellone, Giuseppe AU - Avellone G AD - Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy. LA - eng GR - Budget 10% dottorato 2025 University of Palermo/ PT - Journal Article PL - England TA - J Mass Spectrom JT - Journal of mass spectrometry : JMS JID - 9504818 RN - 0 (Phthalic Acids) RN - 0 (Polyethylene Terephthalates) RN - 0 (Mineral Waters) RN - 0 (Water Pollutants, Chemical) SB - IM MH - *Phthalic Acids/analysis MH - *Polyethylene Terephthalates/chemistry MH - Gas Chromatography-Mass Spectrometry/methods MH - *Mineral Waters/analysis MH - *Water Pollutants, Chemical/analysis MH - Solid Phase Microextraction/methods MH - Limit of Detection MH - Reproducibility of Results MH - Recycling MH - Green Chemistry Technology/methods MH - Food Packaging PMC - PMC13375600 OTO - NOTNLM OT - PET bottles OT - SPME-GC/MS OT - phthalates OT - water EDAT- 2026/07/17 04:03 MHDA- 2026/07/17 19:17 PMCR- 2026/07/17 CRDT- 2026/07/16 22:03 PHST- 2026/03/15 00:00 [revised] PHST- 2025/06/15 00:00 [received] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/07/17 19:17 [medline] PHST- 2026/07/17 04:03 [pubmed] PHST- 2026/07/16 22:03 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - JMS70089 [pii] AID - 10.1002/jms.70089 [doi] PST - ppublish SO - J Mass Spectrom. 2026 Aug;61(8):e70089. doi: 10.1002/jms.70089. PMID- 42462817 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260923 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Metabolites co-correlating with maternal obesity and gestational weight gain and offspring childhood obesity: a prospective birth cohort study. PG - 101437 LID - S0002-9165(26)00246-7 [pii] LID - 10.1016/j.ajcnut.2026.101437 [doi] AB - BACKGROUND: Elevated prepregnancy body mass index (ppBMI) and excessive gestational weight gain (GWG) may contribute to the development of childhood overweight or obesity (COWO), potentially by altering the intrauterine metabolic environment. OBJECTIVES: This study aimed to evaluate the impact of maternal obesity phenotypes on maternal and umbilical cord blood metabolomic profiles, both individually and collectively, and to further examine their association with COWO incidence from preschool through adolescence. METHODS: We analyzed 1253 mother-child dyads with maternal metabolomic data collected 1 to 3 d postpartum and 856 dyads with cord metabolomic data from a prospective multiethnic birth cohort. Metabolomics was profiled using liquid chromatography-tandem mass spectrometry. COWO was defined as a BMI >/= 85th percentile for a specific age and sex. Metabolomic signatures of maternal obesity and scores were derived using linear regression and elastic net regression, and their associations with COWO were assessed via logistic regression. RESULTS: Most maternal metabolites were significantly correlated with corresponding cord metabolites (Spearman's rho: 0.11-0.67; adjusted P < 0.05), except for steroids and certain phospholipids. ppBMI was significantly associated with broad-based alterations in maternal metabolite profiles, particularly medium-chain acylcarnitines, saturated sphingomyelins, triacylglycerols, and phospholipids carrying PUFAs. We further developed ppBMI-related multi-metabolite scores (Pearson's r = 0.43-0.64) that were associated with higher birthweight (beta = 0.07-0.11; P < 0.013) and increased COWO risk (odds ratio: 1.18-1.61; all P < 0.05) from preschool through adolescence. A similar pattern was observed for GWG. In mediation analyses, the maternal metabolite score explained 12.3% (95% confidence interval: 2.18, 24.5; P = 0.02) of the association between ppBMI and BMI z-score at the last well-child visit. CONCLUSIONS: Metabolomic profiles are associated with and may partly mediate the association between maternal obesity, particularly ppBMI, and an increased risk of COWO. These findings warrant validation in independent cohorts. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Yun, Huan AU - Yun H AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Meir, Anat Yaskolka AU - Meir AY AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Hu, Jie AU - Hu J AD - Epidemiology and Center for Genomic Medicine and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. FAU - Wang, Guoying AU - Wang G AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, John Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Hu, Frank B AU - Hu FB AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. FAU - Hong, Xiumei AU - Hong X AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, John Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Wang, Xiaobin AU - Wang X AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, John Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Liang, Liming AU - Liang L AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States. Electronic address: lliang@hsph.harvard.edu. LA - eng GR - R01 ES031521/ES/NIEHS NIH HHS/United States GR - R21 AI171059/AI/NIAID NIH HHS/United States GR - R01 ES031272/ES/NIEHS NIH HHS/United States GR - R21 HD116039/HD/NICHD NIH HHS/United States GR - U01 ES034983/ES/NIEHS NIH HHS/United States GR - R01 HD041702/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260716 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Gestational Weight Gain MH - Prospective Studies MH - Child, Preschool MH - *Pediatric Obesity/etiology/metabolism/epidemiology MH - Birth Cohort MH - Child MH - Body Mass Index MH - *Pregnancy in Obesity/metabolism MH - Male MH - Fetal Blood/metabolism MH - Adult MH - Adolescent MH - *Metabolome MH - Metabolomics MH - Developmental Origins of Health and Disease MH - *Obesity PMC - PMC13390791 MID - NIHMS2196151 OTO - NOTNLM OT - birth cohort OT - childhood overweight or obesity OT - gestational weight gain OT - metabolome OT - prepregnancy BMI COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/17 00:42 MHDA- 2026/09/01 23:34 PMCR- 2026/07/23 CRDT- 2026/07/16 19:11 PHST- 2026/01/22 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/17 00:42 [pubmed] PHST- 2026/07/16 19:11 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - S0002-9165(26)00246-7 [pii] AID - 10.1016/j.ajcnut.2026.101437 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101437. doi: 10.1016/j.ajcnut.2026.101437. Epub 2026 Jul 16. PMID- 42462582 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260831 IS - 1872-8464 (Electronic) IS - 0165-5876 (Linking) VI - 208 DP - 2026 Sep TI - Evaluation of anatomical and ultrasonographic parameters to predict difficult airway in pediatric patients. PG - 112932 LID - S0165-5876(26)00228-4 [pii] LID - 10.1016/j.ijporl.2026.112932 [doi] AB - BACKGROUND: Predicting a difficult airway in pediatric patients remains challenging due to unique anatomical and physiological characteristics. Traditional bedside predictors show inconsistent accuracy in children, and ultrasonography has emerged as a promising, objective tool for airway evaluation. This study aimed to assess the diagnostic performance of anatomical and ultrasonographic parameters in predicting difficult intubation in pediatric patients. METHODS: In this prospective, double-blind observational study, children aged 1-12 years undergoing elective surgery with endotracheal intubation were evaluated. Clinical assessments included anthropometric measurements and airway tests (Mallampati, thyromental distance (TMD), sternomental distance (SMD), hyomental distance (HMD)). Sonographic measurements-skin-epiglottis distance (S-ED) and skin-hyoid distance (S-HD)-were obtained preoperatively. Difficult intubation was defined as Intubation Difficulty Score (IDS) > 5. ROC curve analyses were used to evaluate diagnostic performance; logistic regression identified independent predictors. RESULTS: A total of 240 children were included, with a difficult-intubation incidence of 20%. S-ED demonstrated the highest predictive accuracy (AUC 0.941), followed by S-HD (AUC 0.912), HMD (AUC 0.898), and Mallampati classification (AUC 0.860). TMD and SMD showed moderate predictive ability. Combining significant clinical and sonographic parameters improved diagnostic performance, with S-ED + S-HD yielding an AUC of 0.961. Multivariable regression identified S-ED (OR 4.61), S-HD (OR 1.76), Mallampati >/= III, and facial anomalies as independent predictors of difficult intubation. The final model correctly classified 95.4% of cases. CONCLUSIONS: Ultrasonographic parameters, particularly S-ED and S-HD, are highly accurate predictors of difficult intubation in children and outperform traditional clinical tests. Combining sonographic with anatomical assessments significantly enhances diagnostic performance. Airway ultrasound provides an objective, reproducible, and non-cooperation-dependent tool that can improve preoperative risk stratification in pediatric anesthesia. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Altun, Demet AU - Altun D AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. Electronic address: drdemetaltun@hotmail.com. FAU - Canbaz, Mert AU - Canbaz M AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Dincer, Muserref Beril AU - Dincer MB AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Demirel, Ebru Emre AU - Demirel EE AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Altun, Dilek AU - Altun D AD - Acibadem Mehmet Ali Aydinlar University, Department of Anesthesiology and Reanimation, Istanbul, Turkey. FAU - Kara, Hakan AU - Kara H AD - Istanbul Faculty of Medicine, Department of Otolaryngology & Head and Neck Surgery, Istanbul, Turkey. FAU - Sivrikoz, Nukhet AU - Sivrikoz N AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Camci, Emre AU - Camci E AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. LA - eng PT - Journal Article PT - Observational Study DEP - 20260716 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - Male MH - Child MH - Prospective Studies MH - *Intubation, Intratracheal/methods/adverse effects MH - Infant MH - Ultrasonography MH - Double-Blind Method MH - Predictive Value of Tests MH - ROC Curve MH - Elective Surgical Procedures/methods MH - Pediatric Anesthesia MH - *Airway Management/methods OTO - NOTNLM OT - Airway assessment OT - Difficult airway OT - Pediatric anesthesia OT - Pediatric intubation OT - Skin-epiglottis distance OT - Ultrasonography COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/17 04:03 MHDA- 2026/08/18 23:36 CRDT- 2026/07/16 18:08 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/18 23:36 [medline] PHST- 2026/07/17 04:03 [pubmed] PHST- 2026/07/16 18:08 [entrez] AID - S0165-5876(26)00228-4 [pii] AID - 10.1016/j.ijporl.2026.112932 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2026 Sep;208:112932. doi: 10.1016/j.ijporl.2026.112932. Epub 2026 Jul 16. PMID- 42462323 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260810 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 147 DP - 2026 Nov TI - Sleep patterns and determinants of sleep disturbances in preschool children in the CoAlHaS cohort. PG - 109143 LID - S1389-9457(26)00382-5 [pii] LID - 10.1016/j.sleep.2026.109143 [doi] AB - INTRODUCTION: Sleep disturbances represent a significant public health concern from early childhood, given the long-term implications for health and development. This study examined sleep patterns and factors associated with sleep disturbances in preschool-aged children. METHODS: Data were collected from 1287 participants (544 born in 2018 and 743 born in 2020/21) within the CoAlHaS cohort (Cantabria, Spain). Baseline information was obtained at birth, with follow-up data collected through face-to-face visits, including parent interviews, anthropometric measurements and linkage to medical records. Sleep patterns and disturbances were assessed by the Spanish version of the Children's Sleep Habits Questionnaire (CSHQ-SP). Children were classified as 'poor sleepers' using the validated Spanish threshold of 50.35 points. Associations with perinatal, lifestyle and sociodemographic factors were analysed using one-way ANOVA, independent-samples t-tests and multivariable logistic regression. RESULTS: The prevalence of sleep problems was 36.22% in the total sample. Recommended sleep duration was generally met, although patterns varied between cohorts. Globally, prematurity (OR 2.10, 95% CI 1.24-3.56), increased screen time exposure (OR 1.06, 95% CI 1.01-1.10) and late bedtimes (OR 1.46, 95% CI 0.99-2.13) were linked to being a poor sleeper, whereas higher maternal educational attainment (OR 0.62, 95% CI 0.40-0.96) and younger age (OR 0.24, 95% CI 0.07-0.77) were associated with reduced odds. CONCLUSION: Sleep disturbances are frequent among early childhood, despite achieving recommended sleep duration. Early identification of children at risk and targeted interventions focusing on sleep routines and modifiable family-level factors could be essential to improve sleep habits. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Sanchez-Piorno, L AU - Sanchez-Piorno L AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Gomez-Acebo, I AU - Gomez-Acebo I AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. FAU - Alonso-Molero, J AU - Alonso-Molero J AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. FAU - Valero-Dominguez, S AU - Valero-Dominguez S AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; RICORS Node - Carlos III Health Institute, Madrid, Spain. FAU - Llorente-Pelayo, S AU - Llorente-Pelayo S AD - Department of Pediatrics, Marques de Valdecilla University Hospital, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Lechosa-Muniz, C AU - Lechosa-Muniz C AD - RICORS Node - Carlos III Health Institute, Madrid, Spain; Department of Pediatrics, Marques de Valdecilla University Hospital, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Cabero-Perez, M AU - Cabero-Perez M AD - RICORS Node - Carlos III Health Institute, Madrid, Spain; Department of Pediatrics, Marques de Valdecilla University Hospital, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Dierssen-Sotos, T AU - Dierssen-Sotos T AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. Electronic address: trinidad.dierssen@unican.es. LA - eng PT - Journal Article DEP - 20260715 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - *Sleep Wake Disorders/epidemiology MH - Male MH - Surveys and Questionnaires MH - Prevalence MH - Spain/epidemiology MH - Sleep Duration MH - Cohort Studies MH - *Sleep/physiology MH - Risk Factors OTO - NOTNLM OT - Child OT - Preschool OT - Preterm birth OT - Screen time OT - Sleep wake disorders OT - Socioeconomic factors COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/16 22:01 MHDA- 2026/08/11 00:35 CRDT- 2026/07/16 18:00 PHST- 2026/03/12 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/11 00:35 [medline] PHST- 2026/07/16 22:01 [pubmed] PHST- 2026/07/16 18:00 [entrez] AID - S1389-9457(26)00382-5 [pii] AID - 10.1016/j.sleep.2026.109143 [doi] PST - ppublish SO - Sleep Med. 2026 Nov;147:109143. doi: 10.1016/j.sleep.2026.109143. Epub 2026 Jul 15. PMID- 42462275 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260905 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Jul 16 TI - Physical Activity Monitoring Using Wearable Devices in Young Adults: Secondary Analysis of a 6-Month Motivational Interviewing Pilot Randomized Controlled Trial. PG - e94673 LID - 10.2196/94673 [doi] LID - e94673 AB - In this secondary analysis of a pilot randomized controlled trial of university students aged 18 to 29 years, we assessed the feasibility of providing wearable devices to measure physical activity over 6 months, finding that daily adherence declined over time in both groups, while moderate and vigorous physical activity levels remained similar between the control and intervention groups. CI - (c) Nicolette Christodoulakis, Taylor Incze, Sahar Khademioore, Matthew Kwan, Elizabeth Alvarez, Jean-Eric Tarride, Lawrence Mbuagbaw, Laura N Anderson. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Christodoulakis, Nicolette AU - Christodoulakis N AUID- ORCID: 0000-0001-7852-139X AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. FAU - Incze, Taylor AU - Incze T AUID- ORCID: 0000-0003-4076-8578 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. FAU - Khademioore, Sahar AU - Khademioore S AUID- ORCID: 0000-0002-3025-0006 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. FAU - Kwan, Matthew AU - Kwan M AUID- ORCID: 0000-0002-9757-2771 AD - Department of Child and Youth Studies, Brock University, St. Catharines, ON, Canada. AD - Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada. AD - School of Human Movement and Nutrition Science, The University of Queensland, Brisbane, Queensland, Australia. FAU - Alvarez, Elizabeth AU - Alvarez E AUID- ORCID: 0000-0003-2333-0144 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. AD - Centre for Health Economics and Policy Analysis (CHEPA), McMaster University, Hamilton, ON, Canada. FAU - Tarride, Jean-Eric AU - Tarride JE AUID- ORCID: 0000-0003-2913-7580 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. AD - Centre for Health Economics and Policy Analysis (CHEPA), McMaster University, Hamilton, ON, Canada. AD - Programs for Assessment of Technology in Health (PATH), The Research Institute of St. Joe's Hamilton, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. FAU - Mbuagbaw, Lawrence AU - Mbuagbaw L AUID- ORCID: 0000-0001-5855-5461 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. AD - Biostatistics Unit, Father Sean O'Sullivan Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. AD - Department of Anesthesia, McMaster University, Hamilton, ON, Canada. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada. AD - Centre for Development of Best Practices in Health, Yaounde Central Hospital, Yaounde, Cameroon. AD - Division of Epidemiology and Biostatistics, Department of Global Health, Stellenbosch University, Cape Town, Western Cape, South Africa. FAU - Anderson, Laura N AU - Anderson LN AUID- ORCID: 0000-0002-6106-5073 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. AD - Centre for Health Economics and Policy Analysis (CHEPA), McMaster University, Hamilton, ON, Canada. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20260716 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Exercise/psychology MH - *Motivational Interviewing/methods MH - Pilot Projects MH - *Wearable Electronic Devices/standards MH - Secondary Data Analysis PMC - PMC13375207 OTO - NOTNLM OT - exercise OT - fitness trackers OT - motivational interviewing OT - pilot study OT - wearable electronic devices OT - young adult COIS- Conflicts of Interest: None declared. EDAT- 2026/07/16 22:01 MHDA- 2026/07/17 19:17 PMCR- 2026/07/16 CRDT- 2026/07/16 17:43 PHST- 2026/03/04 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/07/17 19:17 [medline] PHST- 2026/07/16 22:01 [pubmed] PHST- 2026/07/16 17:43 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - v10i1e94673 [pii] AID - 94673 [pii] AID - 10.2196/94673 [doi] PST - epublish SO - JMIR Form Res. 2026 Jul 16;10:e94673. doi: 10.2196/94673. PMID- 42461751 OWN - NLM STAT- Publisher LR - 20260803 IS - 1537-1603 (Electronic) IS - 0736-0258 (Linking) DP - 2026 Jul 16 TI - Peripheral Nerve Cross-Sectional Area in Healthy Thai Children: Reference Values for Clinical Neuromuscular Ultrasound. LID - 10.1097/WNP.0000000000001284 [doi] AB - INTRODUCTION: Ultrasonography of the nerve cross-sectional area (CSA) is increasingly used to support the diagnosis of peripheral neuropathies. However, normative CSA reference values in children, particularly in Southeast Asian populations, are limited. METHODS: Ultrasonographic nerve CSA measurements were conducted in 164 healthy Thai children aged 1 to 18 years at King Chulalongkorn Memorial Hospital, Thailand. Participants were classified into six age groups. CSA was measured in 10 peripheral nerves at 34 anatomical sites and bilateral cervical roots (C5-C7), and the median CSAs were calculated. Correlations between CSA and body weight, height, and age were calculated using Spearman and Pearson correlation coefficients. Intraobserver and interobserver reliability were evaluated in a subset of participants using intraclass correlation coefficients. RESULTS: Normative CSA values were established for all examined nerves and sites. Most nerves demonstrated proximal-to-distal tapering in CSA, with the median nerve exhibiting a unique pattern of larger CSA at the wrist and mid-upper arm. C7 root was the largest cervical root measured (median CSA up to 7.0 mm 2 in older adolescents). CSA demonstrated moderate-to-strong correlations with anthropometric variables, including weight, height, and age ( r = 0.36-0.78). The tibial, sciatic, and median nerves showed the strongest correlations (all P < 0.001). Intraobserver and interobserver reliability were good-to-excellent across the selected nerves. CONCLUSIONS: Nerve CSA is influenced by age, weight, height, and location in this Southeast Asian population. These normative reference values may serve as a reference for distinguishing normal from pathological findings and aid clinical decision making in pediatric neurophysiological practice. CI - Copyright (c) 2026 by the American Clinical Neurophysiology Society. FAU - Paprad, Tanitnun AU - Paprad T AD - Division of Neurology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. AD - Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. FAU - Amornvit, Jakkrit AU - Amornvit J AD - Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. AD - Division of Neurology, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. FAU - Stonsaovapak, Chernkhuan AU - Stonsaovapak C AD - Department of Rehabilitation Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. FAU - Naothaworn, Kamin AU - Naothaworn K AD - Neuroscience Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. FAU - Pasutharnchat, Nath AU - Pasutharnchat N AD - Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. AD - Division of Neurology, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. FAU - Paprad, Tunchanok AU - Paprad T AUID- ORCID: 0000-0002-5281-8248 AD - Department of Radiology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; and. AD - Chulalongkorn International Medical Program, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. LA - eng GR - 66/020/Ratchadapiseksompotch fund, Chulalongkorn University/ PT - Journal Article DEP - 20260716 PL - United States TA - J Clin Neurophysiol JT - Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society JID - 8506708 SB - IM OTO - NOTNLM OT - Cross-sectional area OT - Nerve ultrasound OT - Normal value OT - Pediatric CSA COIS- The authors declare no conflicts of interest. EDAT- 2026/07/16 22:01 MHDA- 2026/07/16 22:01 CRDT- 2026/07/16 12:52 PHST- 2026/07/16 22:01 [pubmed] PHST- 2026/07/16 22:01 [medline] PHST- 2026/07/16 12:52 [entrez] AID - 00004691-990000000-00332 [pii] AID - 10.1097/WNP.0000000000001284 [doi] PST - aheadofprint SO - J Clin Neurophysiol. 2026 Jul 16. doi: 10.1097/WNP.0000000000001284. PMID- 42461426 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261008 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 30 IP - 8 DP - 2026 Jul 16 TI - Association of salivary dynamics, psychological stress, and behavioral factors with tooth wear severity: a cross-sectional study. LID - 339 [pii] LID - 10.1007/s00784-026-07029-w [doi] AB - OBJECTIVES: While the etiology of tooth wear is known to be multifactorial, data regarding the interaction between psychological profile, salivary dynamics, and clinical wear severity remain insufficiently elucidated. This study aimed to analyze the effects of psychological profile and salivary parameters-alongside demographic data, medical history, oral hygiene habits, and dietary patterns-on the severity of clinical tooth wear in a multivariable framework. MATERIALS AND METHODS: Following institutional ethical approval and informed consent, this cross-sectional study included 101 volunteers (90% power), categorized by stress severity (DASS-21: normal, mild, moderate, severe, extremely severe), age groups (18-30, 31-40, 41-50, 51-60, 61-65 years) and salivary pH/buffering capacity levels (low, intermediate, high) for intergroup comparisons. Clinical wear severity was assessed using the Smith and Knight Tooth Wear Index (TWI); psychometric profiles were evaluated via the Depression Anxiety Stress Scale-21 (DASS-21). Salivary analyses (unstimulated pH and stimulated buffering capacity) utilized the GC Saliva-Check Buffer kit. Data were analyzed using independent t-tests, one-way ANOVA, and six-block hierarchical multiple linear regression (p < 0.05). RESULTS: The mean age was 46.7 years; significant differences in TWI scores existed among five age groups (18-30, 31-40, 41-50, 51-60, and 61-65 years; p < 0.05), with the highest wear severity observed in the 61-65 age group (Mean: 2.63). Severe stress (p = 0.008), low salivary pH and insufficient buffering capacity (p = 0.001), and acidic beverage consumption without a straw (p = 0.001) were significantly associated with higher TWI scores. In hierarchical regression, salivary buffering capacity (beta = -0.289), straw use (beta = -0.248), and salivary pH (beta = -0.228) emerged as independent predictors of wear severity (R(2) = 0.519), whereas psychological variables did not contribute independently. CONCLUSIONS: These observational findings suggest that tooth wear severity is associated with the cumulative interplay of biological, behavioral, and psychological factors. Impaired salivary dynamics and specific behavioral patterns were the strongest independent correlates of wear severity; the role of psychological stress appears to operate indirectly, warranting further longitudinal investigation. CLINICAL RELEVANCE: These findings underline the potential value of considering salivary parameters and consumption-related behaviours when evaluating tooth wear risk in adults, while further longitudinal evidence is required before firm clinical recommendations can be made. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Yilmaz, Damla AU - Yilmaz D AUID- ORCID: 0009-0008-2602-877X AD - Department of Restorative Dentistry, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkiye. damlayylmz@gmail.com. FAU - Dereli, Zeynep AU - Dereli Z AUID- ORCID: 0000-0003-2317-9069 AD - Department of Restorative Dentistry, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkiye. LA - eng GR - Project No: 25DU24004/Necmettin Erbakan Universitesi/ GR - Project No: 25DU24004/Necmettin Erbakan Universitesi/ PT - Journal Article DEP - 20260716 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Middle Aged MH - Female MH - Adult MH - Male MH - *Stress, Psychological/complications MH - *Saliva/chemistry/metabolism MH - *Tooth Wear/psychology/etiology MH - Adolescent MH - Aged MH - Young Adult MH - Severity of Illness Index OTO - NOTNLM OT - Cross-sectional study OT - Hierarchical regression OT - Psychological stress OT - Salivary buffering capacity OT - Tooth wear COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Ethics Committee of Necmettin Erbakan University (Date: April 24, 2025/Decision No: 2025/580). Consent to participate: Written informed consent was obtained from all individual participants included in the study. Consent to publish: The authors affirm that human research participants provided informed consent for publication of the images in Fig. 2. Competing interests: The authors declare no competing interests. EDAT- 2026/07/16 16:06 MHDA- 2026/07/16 18:46 CRDT- 2026/07/16 11:15 PHST- 2026/03/07 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/16 18:46 [medline] PHST- 2026/07/16 16:06 [pubmed] PHST- 2026/07/16 11:15 [entrez] AID - 10.1007/s00784-026-07029-w [pii] AID - 10.1007/s00784-026-07029-w [doi] PST - epublish SO - Clin Oral Investig. 2026 Jul 16;30(8):339. doi: 10.1007/s00784-026-07029-w. PMID- 42460647 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) VI - 83 IP - 4 DP - 2026 Oct TI - The illusion of competence: Evaluating the clinical reasoning of large language models in pediatric gastroenterology. PG - 644-651 LID - 10.1002/jpn3.70502 [doi] AB - OBJECTIVE: To evaluate the diagnostic accuracy and clinical reasoning of three frontier large language models (LLMs) across standardized pediatric gastroenterology, hepatology, and nutrition (PGHN) clinical vignettes. METHODS: In this cross-sectional study, 25 fictional PGHN vignettes were developed by one board-certified pediatric gastroenterologist and evaluated using three LLMs: Gemini 3.1 Pro, ChatGPT 5.4 Thinking, and Claude Sonnet 4.6 Extended. A conditional two-step prompting protocol was applied. Three blinded, PGHN-certified co-authors independently scored responses using a structured instrument covering four domains (diagnostic accuracy, management, patient safety, reference quality; 0-2 each) and a global quality of clinical reasoning (QCR) score (1-5 Likert scale). Interobserver reliability was assessed using the intraclass correlation coefficient (ICC). Group differences were analyzed using the Kruskal-Wallis H test with Dunn post-hoc correction. RESULTS: Interobserver reliability was excellent (ICC: 0.98 for domains; 0.87 for QCR). All three models achieved perfect diagnostic accuracy (median 2.00, interquartile range: 2.00-2.00). Statistically significant intermodel differences were identified in reference quality (p = 0.048) and QCR (p = 0.049). Claude achieved significantly higher QCR scores than ChatGPT (p = 0.043) and demonstrated the highest overall reference quality. Qualitative analysis revealed critical pharmacological dosing errors, contextual blindness, temporal obsolescence, and a high frequency of fabricated citations. CONCLUSION: While current LLMs demonstrate good diagnostic pattern recognition in PGHN, reproducible and potentially life-threatening failures in pharmacological reasoning and reference accuracy create a dangerous illusion of competence. These findings suggest that LLMs may support differential diagnosis brainstorming in PGHN but do not establish their safety in real-world clinical scenarios. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Ergen, Yasin Maruf AU - Ergen YM AUID- ORCID: 0000-0002-3689-6852 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Teke, Selcuk AU - Teke S AUID- ORCID: 0000-0002-1885-6611 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Basaran, Edibe Gozde AU - Basaran EG AUID- ORCID: 0000-0003-3165-3234 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Balamtekin, Necati AU - Balamtekin N AUID- ORCID: 0000-0001-8665-5611 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. LA - eng GR - None/ PT - Journal Article DEP - 20260716 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - *Large Language Models MH - Cross-Sectional Studies MH - Reproducibility of Results MH - *Clinical Competence MH - *Pediatrics/standards/methods MH - *Gastroenterology/standards/methods MH - *Clinical Reasoning MH - Observer Variation MH - Child OTO - NOTNLM OT - artificial intelligence OT - clinical decision support OT - guideline concordance OT - hallucination OT - reference hallucination EDAT- 2026/07/16 16:06 MHDA- 2026/10/08 05:31 CRDT- 2026/07/16 06:42 PHST- 2026/04/19 00:00 [revised] PHST- 2026/03/26 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/16 16:06 [pubmed] PHST- 2026/07/16 06:42 [entrez] AID - 10.1002/jpn3.70502 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Oct;83(4):644-651. doi: 10.1002/jpn3.70502. Epub 2026 Jul 16. PMID- 42460424 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260716 LR - 20260813 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 7 DP - 2026 Jul TI - Nutrient Contribution and Acceptability of Dried Small Indigenous Fish Powders for Complementary Feeding in Northern Cameroon. PG - e72116 LID - 10.1002/fsn3.72116 [doi] LID - e72116 AB - Child malnutrition remains a major public health concern in northern Cameroon, where limited access to animal-source foods contributes to persistent undernutrition and micronutrient deficiencies. This study investigated the nutritional composition of small indigenous fish species, documented household knowledge and consumption practices, and evaluated the acceptability of a small-fish-based complementary food. A mixed-methods design was implemented across six localities in the North and Far North regions, combining household surveys (n = 639), qualitative interviews with actors in the fish value chain, nutrient analyses of 19 fish samples, and an acceptability test among children aged 6-23 months (n = 104). Dried small fish showed high nutrient density, with 50.3-64.1 g protein, 11.2-16.7 g fat, and up to 1412 mg calcium per 100 g. A 10 g portion contributed 40%-50% of daily protein needs and up to one-third of calcium requirements for young children. Despite widespread household consumption (92.5%), only 24.6% incorporated small fish into children's meals, reflecting gaps in caregiver knowledge of complementary feeding. The standardized fish powder was well accepted, with mean of hedonic scores of 5.8 +/- 1.2 for taste, 5.6 +/- 1.3 for odor, and 5.7 +/- 1.1 for overall appreciation (p < 0.05 compared with the neutral midpoint of 4.0). Caregivers reported ease of incorporation into common child foods, indicating strong feasibility for household use. These findings demonstrate that small indigenous fish are nutrient-dense, culturally acceptable, and feasible to integrate into complementary feeding. Given the observational nature of the study, conclusions remain cautious. Future research should assess long-term nutritional impacts, evaluate product stability and safety under household storage, and explore scalable models for community-based production. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Christine, Abomo Ndzana Anne AU - Christine ANA AD - Center for Food and Nutrition Research IMPM Yaounde Cameroon. AD - School of Health Sciences Catholic University of Central Africa Yaounde Cameroon. FAU - Josette, Essa'a Veronique AU - Josette EV AD - Center for Food and Nutrition Research IMPM Yaounde Cameroon. FAU - Antoine, Socpa AU - Antoine S AD - School of Health Sciences Catholic University of Central Africa Yaounde Cameroon. AD - Department of Anthropology University of Yaounde 1 Yaounde Cameroon. FAU - Martin, Nankap AU - Martin N AD - UNICEF Yaounde Yaounde Cameroon. FAU - Gabriel, Medoua Nama AU - Gabriel MN AUID- ORCID: 0000-0002-8189-432X AD - Center for Food and Nutrition Research IMPM Yaounde Cameroon. AD - School of Health Sciences Catholic University of Central Africa Yaounde Cameroon. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13369287 OTO - NOTNLM OT - complementary feeding OT - fish powder OT - infant and young child nutrition OT - nutrient intake OT - small indigenous fish COIS- The authors declare no conflicts of interest. EDAT- 2026/07/16 06:38 MHDA- 2026/07/16 06:39 PMCR- 2026/07/14 CRDT- 2026/07/16 04:45 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/16 06:39 [medline] PHST- 2026/07/16 06:38 [pubmed] PHST- 2026/07/16 04:45 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - FSN372116 [pii] AID - 10.1002/fsn3.72116 [doi] PST - epublish SO - Food Sci Nutr. 2026 Jul 14;14(7):e72116. doi: 10.1002/fsn3.72116. eCollection 2026 Jul. PMID- 42460221 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260716 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 6 DP - 2026 Jun TI - Retrospective X-ray Assessment of Wrist Joint Ossification Centers for Age Estimation in a Regional Trauma Center of North India. PG - e110907 LID - 10.7759/cureus.110907 [doi] LID - e110907 AB - Background Age estimation through radiological assessment of skeletal maturation is an important component of forensic and medicolegal practices, particularly in cases involving unidentified individuals, criminal responsibility, employment disputes, and absence of authentic birth records. Ossification and epiphyseal fusion around the wrist joint are considered reliable indicators for estimating chronological age during adolescence and early adulthood. Regional and ethnic variations in skeletal maturation necessitate population-specific standards. This study aimed to retrospectively evaluate the pattern of ossification and epiphyseal fusion around the wrist joint in a Northern Indian population. Methodology This cross-sectional observational study was conducted in the Department of Forensic Medicine and Toxicology under Apex Trauma Centre, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. A total of 174 radiographs of the wrist joint from participants aged 14-24 years were analyzed, including 114 (65.52%) males and 60 (34.48%) females. Participants with chronic illnesses, endocrine disorders, musculoskeletal abnormalities, malnutrition, or unreliable age records were excluded. Radiological assessment included evaluation of epiphyseal fusion at the distal radius and ulna and ossification status of carpal bones. Fusion was classified as non-fusion, partial fusion, or complete fusion. Results Females demonstrated earlier epiphyseal fusion compared to males. At the lower end of the radius and ulna, partial fusion was observed as early as 14-15 years in 10 (62.5%) of 16 females and in 3 (20%) of 15 males at 15-16 years. The earliest complete fusion occurred at 16-17 years in 3 (33.33%) of 9 females and at 17-18 years in 3 (50%) of 6 males. Complete fusion at both the distal end of the radius and ulna was established in all participants (male or female) above 18 years of age. Ossification center for each carpal bone appeared in all participants. Conclusions Radiological examination of ossification centers around the wrist joint is a reliable method for age estimation in adolescents and young adults. The findings provide valuable regional reference data for the population of Eastern Uttar Pradesh and may assist forensic experts in medicolegal age determination. CI - Copyright (c) 2026, Kumar et al. FAU - Kumar, Ankit AU - Kumar A AD - Forensic Medicine and Toxicology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, IND. FAU - Singh, Ashish K AU - Singh AK AD - Forensic Medicine and Toxicology, Government Medical College, Haldwani, Haldwani, IND. FAU - Sharma, Manav AU - Sharma M AD - Forensic Medicine and Toxicology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, IND. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13372195 OTO - NOTNLM OT - age estimation OT - epiphyseal fusion OT - medicolegal OT - ossification center OT - unidentified body OT - wrist joint COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, Sanjay Gandhi Postgraduate Institute of Medical Sciences issued approval 2026-79-IP-EXP-68. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/16 06:38 MHDA- 2026/07/16 06:39 PMCR- 2026/06/15 CRDT- 2026/07/16 04:44 PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/16 06:39 [medline] PHST- 2026/07/16 06:38 [pubmed] PHST- 2026/07/16 04:44 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.7759/cureus.110907 [doi] PST - epublish SO - Cureus. 2026 Jun 15;18(6):e110907. doi: 10.7759/cureus.110907. eCollection 2026 Jun. PMID- 42459815 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261013 IS - 1432-2277 (Electronic) IS - 0934-0874 (Print) IS - 0934-0874 (Linking) VI - 39 DP - 2026 TI - Landscape of current practices and future perspectives in living donor kidney donation in Europe: proceedings of a pan-European symposium by the European kidney transplant association section of the European Society for Organ Transplantation. PG - 16548 LID - 10.3389/ti.2026.16548 [doi] LID - 16548 AB - Living donor kidney transplantation (LDKT) offers superior outcomes for most patients with end-stage kidney disease (ESKD), yet its uptake across Europe remains highly variable. This proceedings article summarizes key themes from a pan-European symposium held in November 2025 in Prague, organized by the European Kidney Transplant Association (EKITA) in collaboration with the DESCaRTES Working Group. Discussions highlighted substantial heterogeneity in LDKT activity across Europe, driven by differences in healthcare capacity, legal frameworks, donor evaluation practices, and access to kidney exchange programmes. Marked inequities persist between regions, particularly in the Balkans and Western Balkans, for women those who are socioeconomically disadvantaged, ethnic minority populations, paediatric and elderly patients and individuals with obesity. The symposium identified wide variation in donor selection criteria, risk assessment, informed consent practices, and long-term donor follow-up, despite existing international guidelines. Emerging strategies to address these challenges include harmonisation of donor evaluation and consent, expansion of paired and cross-border kidney exchange programmes, increased use of unspecified kidney donation, and adoption of innovative surgical and immunological approaches to safely broaden donor eligibility. Advances in outcome measurement, including validated surrogate endpoints, machine learning methods, and integrated, harmonised transplant registries, were discussed as critical tools to improve quality, transparency, and research efficiency. Collectively, the proceedings underscore the need for coordinated clinical, policy, and data-driven solutions to reduce inequities and unlock the full potential of LDKT across Europe, with implications for international transplant practice. CI - Copyright (c) 2026 Kousios, Baas, Manonelles, Ortiz, Rista, Thomas, Lefaucheur, Akin and Marson. FAU - Kousios, Andreas AU - Kousios A AD - School of Medicine, European University Cyprus, Nicosia, Cyprus. AD - Nefrontida Medical Centre, Nicosia, Cyprus. FAU - Baas, Marije AU - Baas M AD - Department of Nephrology, Radboud University Medical Center, Radboud Universiteit, Nijmegen, Netherlands. FAU - Manonelles, Anna AU - Manonelles A AD - Renal Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain. FAU - Ortiz, Fernanda AU - Ortiz F AD - Abdominal Unit, Nephrology, Helsinki University Hospital, Helsinki, Finland. FAU - Rista, Elvana AU - Rista E AD - Department of Nephrology, Dialysis, and Kidney Transplantation, Hygeia International Hospital, Tirana, Albania. FAU - Thomas, Rachel AU - Thomas R AD - Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. FAU - Lefaucheur, Carmen AU - Lefaucheur C AD - Saint Louis Hospital, Assistance Publique- Hopiteux de Paris and Universite Paris Cite, Paris, France. FAU - Akin, Emin Baris AU - Akin EB AD - Department of General Surgery, Demiroglu Bilim University and Group Florence Nightingale Hospital, Istanbul, Turkiye. FAU - Marson, Lorna AU - Marson L AD - Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. LA - eng PT - Conference Proceedings DEP - 20260701 PL - Switzerland TA - Transpl Int JT - Transplant international : official journal of the European Society for Organ Transplantation JID - 8908516 SB - IM EIN - Transpl Int. 2026 Sep 28;39:17772. doi: 10.3389/ti.2026.17772. PMID: 42866521 MH - Humans MH - *Kidney Transplantation/methods/trends MH - *Living Donors MH - Europe MH - *Kidney Failure, Chronic/surgery MH - *Tissue and Organ Procurement/trends MH - Female MH - Donor Selection MH - Informed Consent MH - Risk Assessment PMC - PMC13368691 OTO - NOTNLM OT - cross-border organ exchange OT - donor evaluation and safety OT - equity in transplantation OT - living donor kidney transplantation OT - transplant registry harmonisation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/16 06:34 MHDA- 2026/07/16 13:02 PMCR- 2026/07/01 CRDT- 2026/07/16 04:39 PHST- 2026/03/10 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/16 13:02 [medline] PHST- 2026/07/16 06:34 [pubmed] PHST- 2026/07/16 04:39 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 16548 [pii] AID - 10.3389/ti.2026.16548 [doi] PST - epublish SO - Transpl Int. 2026 Jul 1;39:16548. doi: 10.3389/ti.2026.16548. eCollection 2026. PMID- 42459791 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260716 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - From policy to practice: teacher capacity as the missing link in food and nutrition education reform in Tamil Nadu, India. PG - 1743897 LID - 10.3389/fnut.2026.1743897 [doi] LID - 1743897 AB - INTRODUCTION: Globally, comprehensive education systems for improved public health are thought to include food and nutrition education. The Sustainable Development Goals 2, 3, 4, and 12 are all clearly advocating this. Food and Nutrition Education (FNE) is still implemented unevenly and primarily depends on individual teachers, even with the strong support of policies like India's NEP 2020 and UNESCO's 2024 Global Education Monitoring Report. The current study investigated whether primary school teachers who felt supported by their schools are sufficiently confident in their teaching methods to convert national and international policies and guidelines into real, useful lessons at the classroom level. METHODS: Our study utilized a convergent mixed-methods approach. We surveyed a total of 427 teachers from 12 government primary schools in Tamil Nadu, India. Schools were selected through purposive maximum variation sampling across urban (Chennai) and five adjacent rural districts, and teachers were identified based on continuous service in Grades 1 to 5. Five domain experts validated the instrument with a CVR = 0.94, which included self-efficacy, training history, curricular preferences, and perceived barriers, all of which used a 5-point Likert scale. To analyze quantitative data, SPSS was used v28.0. Levene's test was used to test the homogeneity of variance, and independent samples t-tests were used to compare means between urban and rural areas. The associations between the main variables were quantified using Pearson's r. Implementation confidence was predicted using a hierarchical multiple regression model, after controlling for location, years of experience, training exposure and school infrastructure. The 32 semi-structured interviews were transcribed, translated, and analyzed thematically following Braun and Clarke's framework and inter-coder reliability was found to be kappa = 0.89. The design is in response to the call of OECD for teacher agency in the localization of curriculum. RESULTS: A striking 79.4% of teachers reported no formal training in nutrition pedagogy. Self-efficacy scores were significantly lower among rural teachers (M = 2.0, SD = 0.7) than among their urban counterparts (M = 3.5, SD = 0.8; t(425) = -8.17, p < 0.001, d = 1.63). Teacher confidence was strongly correlated with advocacy for a standalone FNE subject (r = 0.73, p < 0.001). Regression analysis revealed that prior training (beta = 0.54, p < 0.001) and urban location (beta = 0.33, p = 0.001) were the strongest predictors of implementation confidence, together explaining 67% of the variance (R (2) = 0.67, adjusted R (2) = 0.65, F (4, 422) = 78.93, p < 0.001). Qualitative analysis yielded three robust themes: (1) the syllabus squeeze, a structural barrier to dedicated FNE time; (2) the cultural privileging of doctor-led authority over pedagogical expertise; and (3) the absence of state-mandated, contextually relevant teaching modules. DISCUSSION: This research transcends the anecdotal call for the training of teachers by empirically grounding and identifying policy-actionable deficits in educators' capacity. The data clearly show that FNE will remain a peripheral aspiration rather than a core competency if the best pedagogical practices are not adapted. Based on England's statutory Cooking and Nutrition framework, we suggest instituting required FNE modules in B.Ed. and D.Ed. programs to comply with the WHO's 2023 School Nutrition Policy Guidelines while resolving regional delivery issues. CONCLUSION: Therefore, it is crucial to make systematic and ongoing investments in their professional development if primary educators are to confidently deliver food and nutrition education that supports children's growth and development alongside core literacy and numeracy. The shift from merely endorsing policies to building capacity based on evidence is long overdue. Apart from India, many LMICs share the identified obstacles of training gaps, curriculum marginalization, and cultural deference to non-educators. For any LMIC hoping to operationalize global FNE commitments through empowered, classroom-ready teachers, the study provides a scalable diagnostic and prescriptive framework for measuring training exposure, self-efficacy disparities, curricular legitimacy, and institutional barriers to FNE in LMIC contexts. CI - Copyright (c) 2026 Ilangovan, Xavier and Govindarajan. FAU - Ilangovan, Ajit AU - Ilangovan A AD - Vellore Institute of Technology - Chennai Campus, Chennai, India. FAU - Xavier, Savariah AU - Xavier S AD - Vellore Institute of Technology - Chennai Campus, Chennai, India. FAU - Govindarajan, P AU - Govindarajan P AD - Vellore Institute of Technology - Chennai Campus, Chennai, India. LA - eng PT - Journal Article DEP - 20260701 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13368667 OTO - NOTNLM OT - curriculum integration OT - food literacy OT - nutrition education policy OT - pedagogical capacity OT - primary education reform COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/16 06:39 MHDA- 2026/07/16 06:40 PMCR- 2026/07/01 CRDT- 2026/07/16 04:39 PHST- 2025/11/11 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/16 06:40 [medline] PHST- 2026/07/16 06:39 [pubmed] PHST- 2026/07/16 04:39 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.3389/fnut.2026.1743897 [doi] PST - epublish SO - Front Nutr. 2026 Jul 1;13:1743897. doi: 10.3389/fnut.2026.1743897. eCollection 2026. PMID- 42458481 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260822 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 24 IP - 1 DP - 2026 Jul 15 TI - Handgrip strength in children, adolescents, and young adults with suspected myalgic encephalomyelitis/chronic fatigue syndrome. LID - 10.1186/s12967-026-08654-5 [doi] LID - 947 AB - BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in children and young people (CYP) lacks validated diagnostic biomarkers. Post-exertional malaise (PEM) is central to case definitions and is usually assessed by patient report. We evaluated the feasibility and clinical value of handgrip strength (HGS) testing in PEM-reporting CYP referred for suspected ME/CFS. METHODS: In this prospective observational study at the Munich Chronic Fatigue Center for Young People (November 2022-November 2024), 147 patients (10-25 years) referred for the assessment of ME/CFS with positive DSQ-PEM screening and 83 healthy controls (HC) completed two HGS sessions (10 maximal grips/session; 3-s contraction/5-s rest; 60-minute inter-session break) using a digital dynamometer. We derived maximal force (Fmax), mean force (Fmean), fatigue ratio (FR = Fmax/Fmean), and recovery ratio (RR = Fmean session 2 / session 1). Analyses used repeated-measures ANCOVA, linear regression, partial Spearman correlations (adjusted for sex, age, and BMI), and proportional odds models for group membership (HC, noME/CFS, ME/CFS), reporting accuracy, and the C-statistic. Sensitivity analyses compared noME/CFS with confirmed CCC-ME/CFS. RESULTS: After clinical work-up, 84/147 (57%) patients were classified as ME/CFS (confirmed or probable) and 63/147 (43%) as noME/CFS. HGS test completion rate was high (session 1: 146/147, 99.3%; session 2: 142/147, 96.6%). Compared with HC, patients had substantially lower HGS (mean difference -9.93 kg, 95% CI: -12.00 to -7.85), and HGS indices correlated modestly with physical functioning (SF-12 PCS), but not with PEM duration. Both noME/CFS and ME/CFS groups differed from HC in absolute strength indices (Fmean, Fmax) and FR. RR differed between ME/CFS and HC, whereas no HGS index significantly separated noME/CFS from ME/CFS. In proportional odds models, each HGS index improved fit (all p < 0.001), but discrimination across HC, noME/CFS, and ME/CFS patients was moderate (accuracy 49.2-57.3% vs no-information rate 36.5%, with best performance for Fmean in session 2). In the CCC-restricted sensitivity analysis, discrimination between confirmed CCC-ME/CFS and noME/CFS was moderate (accuracy 62.8-70.7%; C-statistic 0.63-0.73), with best performance for absolute strength indices and RR. CONCLUSIONS: Standardized two-session repeated HGS testing is feasible in CYP with chronic fatigue and self-reported PEM and provides an objective marker of functional impairment that aligns with physical health status but not with PEM duration. However, HGS alone shows limited ability to discriminate ME/CFS from other fatiguing noME/CFS conditions. HGS may be useful for quantitative phenotyping, patient stratification, and longitudinal outcome assessment rather than as a standalone diagnostic biomarker. TRIAL REGISTRATION: Not applicable. CI - (c) 2026. The Author(s). FAU - Mihatsch, Lorenz AU - Mihatsch L AUID- ORCID: 0000-0003-3835-7964 AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. L.Mihatsch@tum.de. FAU - Schartner, Lisa AU - Schartner L AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - de Luna, Julia Lange AU - de Luna JL AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Hohler, Chiara AU - Hohler C AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Bucka, Lara AU - Bucka L AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Lovrenovic, Lea AU - Lovrenovic L AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Eidenschink, Sophie AU - Eidenschink S AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Schmuck, Birgit AU - Schmuck B AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Bienemann, Viktoria AU - Bienemann V AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Christa, Catharina AU - Christa C AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Mittelstrass, Kirstin AU - Mittelstrass K AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Hausruckinger, Anna AU - Hausruckinger A AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Warlitz, Cordula AU - Warlitz C AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Michel, Kaja AU - Michel K AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Gerrer, Katrin AU - Gerrer K AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Freitag, Helma AU - Freitag H AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, Berlin, 13353, Germany. FAU - Scheibenbogen, Carmen AU - Scheibenbogen C AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, Berlin, 13353, Germany. FAU - Pricoco, Rafael AU - Pricoco R AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Behrends, Uta AU - Behrends U AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. AD - German Center for Infection Research, Partnersite Munich, Munich, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260715 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 SB - IM MH - Humans MH - *Fatigue Syndrome, Chronic/physiopathology/diagnosis MH - *Hand Strength/physiology MH - Child MH - Adolescent MH - Female MH - Young Adult MH - Male MH - Adult MH - Case-Control Studies PMC - PMC13393269 OTO - NOTNLM OT - Handgrip strength OT - ME/CFS OT - PEM OT - Pediatrics OT - Post-COVID OT - Post-Exertional malaise OT - Post-Vaccination COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Institutional Review Board of the TUM University Hospital (2022-585_1) and adheres to the Declaration of Helsinki and its subsequent amendments. Written informed consent was obtained from all participants prior to their inclusion, and in case of minors, from their legal guardians. Consent for publication: Not applicable. Competing interest: U.B. reports research funding from the Bavarian State Ministry of Health and Care, the Bavarian State Ministry of Science and Art, the German Center for Infection Research (DZIF), the Federal Ministry of Research, Technology and Space, the Federal Ministry of Health, and the Federal Joint Committee. All other authors report no conflict of interest. EDAT- 2026/07/16 00:35 MHDA- 2026/07/23 06:39 PMCR- 2026/07/15 CRDT- 2026/07/16 00:01 PHST- 2026/03/08 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/23 06:39 [medline] PHST- 2026/07/16 00:35 [pubmed] PHST- 2026/07/16 00:01 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1186/s12967-026-08654-5 [pii] AID - 8654 [pii] AID - 10.1186/s12967-026-08654-5 [doi] PST - epublish SO - J Transl Med. 2026 Jul 15;24(1):947. doi: 10.1186/s12967-026-08654-5. PMID- 42458400 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261016 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jul 15 TI - Panoramic radiograph-based dental age estimation in children and adolescents using multi-tooth methods: a scoping review of methods used and reported accuracy (2020-2025). LID - 10.1186/s12903-026-09263-w [doi] LID - 2005 AB - BACKGROUND: Accurate dental age estimation supports treatment planning in pediatric dentistry and orthodontics and forensic assessment when chronological age is uncertain. Because the accuracy of panoramic radiograph-based methods varies across populations, age groups, and method variants, a contemporary synthesis is needed to guide method selection. OBJECTIVE: To map the methods used for panoramic radiograph-based dental age estimation in children and adolescents and to summarize the reported diagnostic accuracy of the most frequently used method families in studies published between 2020 and 2025. METHODS: This scoping review was conducted using PubMed, Scopus, and Web of Science. Studies published between 1 January 2020 and 31 December 2025 were screened according to predefined eligibility criteria. Data were extracted using a standardized form, including study characteristics, dental age estimation methods, and reported accuracy outcomes (primarily mean absolute error [MAE] and mean difference/bias [DA-CA]). Thirty-four original studies were included. RESULTS: The included studies comprised over 35,000 children and adolescents from multiple countries and were predominantly retrospective and clinic-based. Willems-family methods were the most frequently reported, followed by Demirjian-, Cameriere-, and London Atlas-based approaches. Across studies, accuracy reporting was heterogeneous with respect to MAE, bias metrics, sex stratification, and method variants. Cameriere family methods often showed lower MAE values in many cohorts; however, performance varied by population, age range, and method modification. CONCLUSION: Panoramic radiograph-based dental age estimation methods show substantial heterogeneity in use and reported accuracy across populations. Willems-family methods are the most frequently applied, whereas Cameriere-family methods often demonstrate favorable accuracy in many cohorts, but no single method can be considered universally optimal. Population-specific validation and standardized reporting of accuracy metrics are needed. CI - (c) 2026. The Author(s). FAU - Lysiak-Majchrzak, Malgorzata AU - Lysiak-Majchrzak M AUID- ORCID: 0009-0003-0611-173X AD - Department of Maxillofacial Orthopedics and Orthodontics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. malgorzata.lysiak-majchrzak@cm.umk.pl. FAU - Jagla, Sylwia AU - Jagla S AUID- ORCID: 0000-0002-6709-334X AD - Department of Maxillofacial Orthopedics and Orthodontics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. FAU - Kazimierczak, Natalia AU - Kazimierczak N AUID- ORCID: 0000-0002-1850-3525 AD - Department of Maxillofacial Orthopedics and Orthodontics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. AD - Kazimierczak Clinic, Dworcowa 13/u6a, Bydgoszcz, Poland. FAU - Kazimierczak, Wojciech AU - Kazimierczak W AUID- ORCID: 0000-0002-8372-0550 AD - Kazimierczak Clinic, Dworcowa 13/u6a, Bydgoszcz, Poland. AD - Department of Radiology and Diagnostic Imaging, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. FAU - Matthews-Brzozowska, Teresa AU - Matthews-Brzozowska T AUID- ORCID: 0000-0002-7127-6018 AD - Department of Maxillofacial Orthopedics and Orthodontics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. LA - eng PT - Journal Article PT - Scoping Review PT - Systematic Review DEP - 20260715 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - *Radiography, Panoramic/methods MH - Child MH - Adolescent PMC - PMC13663167 OTO - NOTNLM OT - Accuracy OT - Cameriere Method OT - Child OT - Dental Age OT - Panoramic radiography OT - Tooth OT - Willems Method COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: All authors have approved the manuscript for submission. Competing interests: The authors declare no competing interests. EDAT- 2026/07/16 00:35 MHDA- 2026/10/14 05:33 PMCR- 2026/07/15 CRDT- 2026/07/15 23:58 PHST- 2026/03/04 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/10/14 05:33 [medline] PHST- 2026/07/16 00:35 [pubmed] PHST- 2026/07/15 23:58 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1186/s12903-026-09263-w [pii] AID - 9263 [pii] AID - 10.1186/s12903-026-09263-w [doi] PST - epublish SO - BMC Oral Health. 2026 Jul 15;26(1):2005. doi: 10.1186/s12903-026-09263-w. PMID- 42458369 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260926 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 15 TI - Agreement between household food insecurity access scale and an imputed food consumption score in urban Ethiopia: implications for targeting. LID - 10.1186/s12887-026-07340-1 [doi] LID - 898 AB - BACKGROUND: The Food Consumption Score (FCS) and Household Food Insecurity Access Scale (HFIAS) measure different domains of food security, namely dietary diversity versus perceived access constraints. In urban Ethiopia, it is unknown whether these indicators classify the same households as food insecure. This study compared FCS and HFIAS classifications among households with young children and quantified discordance between the two measures. METHODS: This secondary analysis used cross-sectional data from 542 households with children aged 6-23 months attending public health centers in Harar City, Eastern Ethiopia (July-August 2024). The original study assessed determinants of animal-source food consumption; the current comparative analysis was a pre-specified secondary objective. FCS was calculated from 7-day food frequency data using standard WFP thresholds. Missing oil and sugar values (100% missing) were imputed as 3 days/week with sensitivity analyses under alternative assumptions. HFIAS categories used continuous score cutoffs validated in Ethiopian studies. Agreement was assessed using Cohen's kappa, prevalence-adjusted bias-adjusted kappa (PABAK), and discordance analysis. Bootstrap methods calculated 95% confidence intervals. Multivariable logistic regression identified predictors of discordance. RESULTS: FCS classified 34.5% as acceptable, 28.6% borderline, and 36.9% poor. HFIAS classified 20.1% as food secure, 28.0% mildly, 33.0% moderately, and 18.8% severely insecure. Overall agreement was 48.5% with kappa of 0.31 (95% CI: 0.25-0.37), indicating fair agreement. PABAK was 0.42 (95% CI: 0.36-0.48). Discordance occurred in 51.5% of households: 22.9% were HFIAS-secure but FCS poor/borderline; 28.6% were HFIAS-insecure but FCS acceptable. Poorest wealth quintile (AOR = 2.43, 95% CI: 1.38-4.28) and no maternal education (AOR = 1.87, 95% CI: 1.12-3.14) were independently associated with higher odds of discordance. CONCLUSIONS: FCS and HFIAS measure different dimensions of household food security and demonstrate only fair agreement in this urban Ethiopian population. Neither measure alone provides a complete picture. The finding that more than half of households are discordantly classified highlights the importance of measuring both dietary consumption and perceived access whenever resources permit. The choice of indicator should be guided by assessment objectives and available resources. CI - (c) 2026. The Author(s). FAU - Belay, Bira AU - Belay B AUID- ORCID: 0009-0006-3969-1744 AD - School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. birabelay555@gmail.com. FAU - Nega, Bereketabe AU - Nega B AD - School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. FAU - Daba, Yalo AU - Daba Y AD - Pharmacology Department, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. LA - eng PT - Journal Article DEP - 20260715 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Ethiopia MH - Humans MH - *Food Insecurity MH - Cross-Sectional Studies MH - Male MH - Female MH - Urban Population MH - Infant MH - *Food Supply/statistics & numerical data MH - *Family Characteristics PMC - PMC13602524 OTO - NOTNLM OT - Agreement OT - Cohen's kappa OT - Dietary diversity OT - Ethiopia OT - FCS OT - Food Consumption Score OT - Food insecurity OT - HFIAS OT - Urban COIS- Declarations. Ethics approval and consent to participate: The original study received ethical approval from Haramaya University's Institutional Health Research Ethics Review Committee (Ref: IHRERC/164/2024). Written informed consent was obtained from all participating mothers. This secondary analysis of de-identified data was reviewed by the same committee and granted exemption from full review (Ref: IHRERC/045/2024) on the basis that it involved analysis of existing, anonymized data with no participant contact. All procedures complied with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/16 00:34 MHDA- 2026/09/24 05:36 PMCR- 2026/07/15 CRDT- 2026/07/15 23:57 PHST- 2026/05/13 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/24 05:36 [medline] PHST- 2026/07/16 00:34 [pubmed] PHST- 2026/07/15 23:57 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1186/s12887-026-07340-1 [pii] AID - 7340 [pii] AID - 10.1186/s12887-026-07340-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 15;26(1):898. doi: 10.1186/s12887-026-07340-1. PMID- 42456231 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1878-7487 (Electronic) IS - 1752-928X (Linking) VI - 122 DP - 2026 Aug TI - Classifying legal age of majority (>/=18 years) from panoramic radiographs with transfer learning: Benchmarking ViT and EfficientNetV2. PG - 103215 LID - S1752-928X(26)00148-4 [pii] LID - 10.1016/j.jflm.2026.103215 [doi] AB - OBJECTIVE: To assess whether transfer-learning models applied to panoramic radiographs (PANs) can classify individuals at the threshold of legal majority (>/=18 years). MATERIALS AND METHODS: Vision Transformer (ViT) and EfficientNetV2 models were trained on PANs from Bosnian and Lebanese individuals aged 14-24.99 years (n = 1764), considering pooled and sex-specific datasets with and without augmentation. Binary classification, multiclass classification, and regression models were trained and evaluated. Model performance on an internal test set derived from the same sample was summarized using accuracy, sensitivity, specificity, F1 score, and area under the receiver operating characteristic curve (ROC AUC). For regression and multiclass models, legal majority classification was additionally assessed by thresholding predicted ages or age categories at 18 years. External validation employed an independent Brazilian dataset (n = 1579; 14-24.99 years). Formal statistical comparison between internal and external performance employed two-proportion z-tests for accuracy and DeLong's test for ROC AUC. RESULTS: On the internal test set, the best-performing binary classification model, EfficientNetV2 with augmentation on the pooled dataset, achieved an accuracy of 0.90, sensitivity of 0.92, specificity of 0.86, F1 score of 0.91, and ROC AUC of 0.93. Using the same pooled, augmented configuration, thresholded regression predictions achieved accuracies of 0.85 for EfficientNetV2 and 0.83 for ViT, whereas thresholded multiclass predictions achieved accuracies of 0.84 and 0.73, respectively. Compared with direct binary classification, these thresholded outputs showed no clear advantage, and multiclass models generally showed higher specificity but lower sensitivity. This same pattern was retained when thresholded models were evaluated on the external validation set, with thresholded regression remaining comparatively stable and thresholded multiclass performance declining more markedly, especially for ViT. Visualization maps (gradient-weighted class activation mapping [Grad-CAM] and occlusion sensitivity) confirmed attention to relevant dental structures. On external validation, the same binary EfficientNetV2 configuration achieved an accuracy of 0.81, sensitivity of 0.90, specificity of 0.61, F1 score of 0.87, and ROC AUC of 0.85. Sex-specific models performed similarly, showing no clear advantage over pooled training. Statistical testing confirmed significant AUC degradation on external validation for both models (EfficientNetV2: p = 0.004; ViT: p < 0.001), while the accuracy drop was significant only for ViT (p = 0.035). CONCLUSIONS: This study demonstrated that transfer learning with EfficientNetV2 and Vision Transformer can distinguish minors from adults using PANs with high internal performance and acceptable external generalization. Direct binary classification provided the most robust approach for legal age assessment in the present dataset. The findings support the forensic potential of these models, while also indicating the need for further work to improve robustness and real-world applicability. CI - Copyright (c) 2026 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved. FAU - Constantinou, Chrysovalantis AU - Constantinou C AD - Computation-based Science and Technology Research Center, The Cyprus Institute, Aglantzia, Nicosia, 2121, Cyprus. Electronic address: cconsta1@alumni.nd.edu. FAU - Georgiades, Pantelis AU - Georgiades P AD - Computation-based Science and Technology Research Center, The Cyprus Institute, Aglantzia, Nicosia, 2121, Cyprus; Climate and Atmosphere Research Centre, The Cyprus Institute, Aglantzia, Nicosia, 2121, Cyprus. FAU - Angelakopoulos, Nikolaos AU - Angelakopoulos N AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland; Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. FAU - Hadzic Selmanagic, Aida AU - Hadzic Selmanagic A AD - Department of Dental Morphology with Dental Anthropology and Forensics, Faculty of Dentistry, University of Sarajevo, Sarajevo, Bosnia and Herzegovina. FAU - Dervisevic, Emina AU - Dervisevic E AD - Department of Forensic Medicine, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina. FAU - Moukarzel, Maria AU - Moukarzel M AD - Private Dental Practice, Beirut, Lebanon. FAU - Franco, Ademir AU - Franco A AD - Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. FAU - Merdietio Boedi, Rizky AU - Merdietio Boedi R AD - Department of Dentistry, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia. LA - eng PT - Journal Article DEP - 20260715 PL - England TA - J Forensic Leg Med JT - Journal of forensic and legal medicine JID - 101300022 SB - IM MH - Humans MH - *Radiography, Panoramic MH - Adolescent MH - *Age Determination by Teeth/methods MH - Young Adult MH - Female MH - Male MH - ROC Curve MH - Classification Algorithms MH - Sensitivity and Specificity OTO - NOTNLM OT - Dental age classification OT - Forensic dentistry OT - Legal age of majority OT - Panoramic radiograph OT - Transfer learning COIS- Conflict of interest The authors declare no competing interests. EDAT- 2026/07/15 18:41 MHDA- 2026/08/26 23:35 CRDT- 2026/07/15 18:01 PHST- 2025/03/11 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/26 23:35 [medline] PHST- 2026/07/15 18:41 [pubmed] PHST- 2026/07/15 18:01 [entrez] AID - S1752-928X(26)00148-4 [pii] AID - 10.1016/j.jflm.2026.103215 [doi] PST - ppublish SO - J Forensic Leg Med. 2026 Aug;122:103215. doi: 10.1016/j.jflm.2026.103215. Epub 2026 Jul 15. PMID- 42455961 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1520-7560 (Electronic) IS - 1520-7552 (Print) IS - 1520-7552 (Linking) VI - 42 IP - 5 DP - 2026 Jul TI - Disordered Eating Behaviours and Associated Factors Among People With Type 1 Diabetes: A Cross-Sectional Study in Spain-D1ANAS Project. PG - e70204 LID - 10.1002/dmrr.70204 [doi] LID - e70204 AB - BACKGROUND AND AIMS: People with type 1 diabetes mellitus (T1D) are at increased risk of disordered eating behaviours (DEBs), partly due to aspects of diabetes management. The aim of this study was to estimate the prevalence of DEBs in a group of adults with T1D in Spain and to examine their association with sociodemographic, clinical, and lifestyle-related factors. METHODS: A nationwide cross-sectional study was conducted as part of the D1ANAS project, involving 451 people aged >/= 16 years with T1D living in Spain. DEBs were assessed using the validated Spanish version of the Diabetes Eating Problems Survey-Revised (DEPS-R), with scores >/= 20 indicating a positive screening. Sociodemographic, clinical, and lifestyle variables were collected using a self-administered online questionnaire. Multivariate linear regression analyses were performed to identify factors independently associated with the total DEPS-R score. RESULTS: The mean DEPS-R score was 16.8 (SD 12.1), and 31.7% of participants screened positive for DEBs, with higher prevalence in women than men (35.4% vs. 14.8%, p < 0.001) 36.6% of participants reported insulin restriction behaviours, with no significant differences between sexes. In the adjusted models, female sex (beta = 3.23, 95% CI = 0.65-5.82), higher HbA1c percentage (beta = 2.12, 95% CI = 1.32-2.93), and higher zBMI (beta = 3.44, 95% CI = 2.44-4.44) were independently associated with higher DEPS-R scores, as were poorer perceived health (beta = 5.11, 95% CI = 2.25-7.96), poorer diet quality (beta = 13.42, 95% CI = 7.23-19.61) and poor sleep perception (beta = 3.43, 95% CI = 1.46-5.39). The model explained 29.6% of the variance in DEPS-R scores. CONCLUSION: DEBs affect about one-third of the participants with T1D and are associated with poorer metabolic control, higher BMI, and adverse lifestyle and psychosocial factors, highlighting the need for diabetes-specific screening and multidisciplinary management. CI - (c) 2026 The Author(s). Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd. FAU - Botella-Juan, Lorena AU - Botella-Juan L AUID- ORCID: 0000-0002-4886-1673 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Aguilera-Buenosvinos, Inmaculada AU - Aguilera-Buenosvinos I AUID- ORCID: 0000-0002-9484-7303 AD - Faculty of Health Sciences, International University of La Rioja, Logrono, Spain. FAU - Antequera-Gonzalez, Maria AU - Antequera-Gonzalez M AD - Servicio de Endocrinologia y Nutricion, Complejo Asistencial Universitario de Leon, Gerencia de Salud de Castilla y Leon (SACYL), Leon, Spain. FAU - Alvarez-Alvarez, Laura AU - Alvarez-Alvarez L AUID- ORCID: 0000-0002-4915-8314 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Rubin-Garcia, Maria AU - Rubin-Garcia M AUID- ORCID: 0000-0003-0916-4215 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Romeo-Santos, Maria AU - Romeo-Santos M AD - Hospital General Universitario Gregorio Maranon, Madrid, Spain. FAU - Segura-Grau, Ana AU - Segura-Grau A AUID- ORCID: 0000-0003-3701-2788 AD - Ultrasound Unit, Family and Community Medicine, San Francisco de Asis Hospital, Madrid, Spain. AD - SEMERGEN (Spanish Society of Primary Care Physicians), Madrid, Spain. FAU - Ballesteros-Pomar, Maria D AU - Ballesteros-Pomar MD AUID- ORCID: 0000-0002-5729-9926 AD - Servicio de Endocrinologia y Nutricion, Complejo Asistencial Universitario de Leon, Gerencia de Salud de Castilla y Leon (SACYL), Leon, Spain. AD - Instituto de Investigacion Biosanitaria de Leon (IBIOLEON), Leon, Spain. FAU - Molina, Antonio Jose AU - Molina AJ AUID- ORCID: 0000-0002-5948-6397 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Martin-Sanchez, Vicente AU - Martin-Sanchez V AUID- ORCID: 0000-0003-0552-2804 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. LA - eng PT - Journal Article PL - England TA - Diabetes Metab Res Rev JT - Diabetes/metabolism research and reviews JID - 100883450 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/complications/psychology MH - Female MH - Cross-Sectional Studies MH - Male MH - *Feeding and Eating Disorders/epidemiology/etiology/psychology MH - Spain/epidemiology MH - Adult MH - Prevalence MH - Middle Aged MH - Young Adult MH - Adolescent MH - Risk Factors MH - Follow-Up Studies MH - *Feeding Behavior/psychology MH - Life Style MH - Prognosis MH - Surveys and Questionnaires PMC - PMC13372235 OTO - NOTNLM OT - diabetes mellitus OT - disordered eating behaviours OT - eating disorders OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 18:41 MHDA- 2026/07/15 18:42 PMCR- 2026/07/15 CRDT- 2026/07/15 14:13 PHST- 2026/06/12 00:00 [revised] PHST- 2026/03/20 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 18:41 [pubmed] PHST- 2026/07/15 14:13 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - DMRR70204 [pii] AID - 10.1002/dmrr.70204 [doi] PST - ppublish SO - Diabetes Metab Res Rev. 2026 Jul;42(5):e70204. doi: 10.1002/dmrr.70204. PMID- 42455830 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Cross-cultural assessment of knowledge and attitudes toward Folic acid: Instrument development and validation in Thailand and Yemen. PG - e0352966 LID - 10.1371/journal.pone.0352966 [doi] LID - e0352966 AB - Folic acid is essential for the prevention of neural tube defects and other congenital anomalies, yet awareness and uptake vary across cultural and resource settings. Reliable tools to assess women's knowledge and attitudes toward Folic acid are limited, particularly in cross-cultural contexts. This study aimed to develop and validate a culturally adaptable questionnaire in two distinct populations: Thailand and Yemen. In this cross-sectional instrument development and validation study, the questionnaire was developed through literature review and expert consultation, and comprised demographics, eight knowledge items, and ten attitude items. Following content validation, pilot testing, and test-retest reliability assessment, exploratory and confirmatory factor analyses were performed. Cronbach's alpha was calculated for internal consistency. Data were collected from 538 women of reproductive age (Thai: 104; Yemeni: 434) via an online self-administered survey. The attitude scale demonstrated strong psychometric properties, with high internal consistency (alpha = 0.88 in both groups), coherent factor structures, and excellent model fit in the Yemeni sample (RMSEA = 0.054, CFI = 0.973, TLI = 0.965). Knowledge scores varied across items, with higher awareness in dietary source and timing-related items, and lower scores in statistical and biological knowledge. The Yemeni version showed lower internal consistency in the knowledge section (alpha = 0.59), reflecting content heterogeneity. Despite contextual differences, the instrument demonstrated psychometric coherence in both groups, though model fit was more robust in the Yemeni sample. In conclusion, this study developed and validated a brief questionnaire to assess knowledge and attitudes toward Folic acid in culturally diverse settings. The tool showed good psychometric performance and is suitable for use in research and public health interventions, particularly in low-resource or cross-cultural environments. CI - Copyright: (c) 2026 Al-Qaari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Al-Qaari, Rana Ali AU - Al-Qaari RA AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Khuankaew, Saranthorn AU - Khuankaew S AD - Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Suttiserm, Mahittha AU - Suttiserm M AD - Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Pornsuksawang, Siraphat AU - Pornsuksawang S AD - Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Boonnop, Pawat AU - Boonnop P AD - Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Manopatanakul, Somchai AU - Manopatanakul S AUID- ORCID: 0000-0002-6771-2243 AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Khovidhunkit, Siribang-On Piboonniyom AU - Khovidhunkit SP AUID- ORCID: 0000-0002-4496-7964 AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Thiradilok, Sasipa AU - Thiradilok S AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Tantipoj, Chanita AU - Tantipoj C AUID- ORCID: 0000-0001-9400-6726 AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. LA - eng PT - Journal Article PT - Validation Study DEP - 20260715 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 935E97BOY8 (Folic Acid) SB - IM MH - Humans MH - Female MH - *Folic Acid/therapeutic use MH - Yemen MH - *Health Knowledge, Attitudes, Practice MH - Thailand MH - Surveys and Questionnaires MH - Adult MH - Cross-Sectional Studies MH - Psychometrics MH - Cross-Cultural Comparison MH - Reproducibility of Results MH - Young Adult MH - Adolescent PMC - PMC13372155 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/15 18:41 MHDA- 2026/07/15 18:42 PMCR- 2026/07/15 CRDT- 2026/07/15 13:43 PHST- 2025/11/28 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 18:41 [pubmed] PHST- 2026/07/15 13:43 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - PONE-D-25-58912 [pii] AID - 10.1371/journal.pone.0352966 [doi] PST - epublish SO - PLoS One. 2026 Jul 15;21(7):e0352966. doi: 10.1371/journal.pone.0352966. eCollection 2026. PMID- 42455824 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Reliability and validity of the individual GPS game data-based maximal acceleration-initial running speed regression line in youth elite soccer players. PG - e0353385 LID - 10.1371/journal.pone.0353385 [doi] LID - e0353385 AB - Modern load monitoring in soccer increasingly employs relative individualized acceleration intensity thresholds derived from individual maximal acceleration-initial running speed (amax-vinit) regression lines. This study examined the reliability and validity of soccer players' individual amax-vinit regression lines determined solely from game locomotion data. Using a GPS-based tracking system, we prospectively collected game locomotion data from 159 male youth elite soccer players over one season and repeatedly determined their amax-vinit regression lines using a recently introduced game data-based method. To examine the influence of data volume, regression lines were determined using different numbers of consecutive games. As a criterion measure, the amax-vinit regression line was determined using an acceleration test in 55 athletes. Reliability was assessed via the typical error (TE) and the intraclass correlation coefficient (ICC), and validity via the typical error of the estimate (TEE) and the Pearson correlation coefficient. The magnitude of errors and correlation coefficients was assessed using standardization and published thresholds, respectively. Reliability improved gradually with increasing data volume, resulting in TEs of 3.4% (amax intercept), 7.3% (vinit intercept), and 10.3% (slope). Nonetheless, all TEs were large in magnitude, and ICCs very low to low. Validity was unaffected by data volume, with TEEs consistently ~7% (amax intercept), ~ 12% (vinit intercept), and ~17% (slope). All TEEs were assessed as extremely large, and Pearson correlations as impractical. These findings indicate that the game data-based method currently lacks the precision required for individual-level applications, and this limitation cannot be resolved simply by including more games. Therefore, establishing relative individualized acceleration intensity thresholds within a team still requires a test-based approach. Moreover, the results suggest that properties inherent in GPS-based game locomotion data, rather than data volume, underlie the observed imprecision. We propose that substantial future improvements will depend on more precise tracking systems. CI - Copyright: (c) 2026 Andrey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Andrey, Pascal AU - Andrey P AUID- ORCID: 0000-0002-0812-8899 AD - Department of Elite Sport, Swiss Federal Institute of Sport Magglingen SFISM, Magglingen, Bern, Switzerland. FAU - Fischer-Sonderegger, Karin AU - Fischer-Sonderegger K AD - Department of Elite Sport, Swiss Federal Institute of Sport Magglingen SFISM, Magglingen, Bern, Switzerland. FAU - Taube, Wolfgang AU - Taube W AD - Department of Neurosciences and Movement Science, University of Fribourg, Fribourg, Fribourg, Switzerland. FAU - Tschopp, Markus AU - Tschopp M AUID- ORCID: 0009-0007-3446-2907 AD - Department of Elite Sport, Swiss Federal Institute of Sport Magglingen SFISM, Magglingen, Bern, Switzerland. LA - eng PT - Journal Article DEP - 20260715 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Soccer/physiology MH - *Running/physiology MH - *Geographic Information Systems MH - Male MH - Reproducibility of Results MH - *Acceleration MH - Adolescent MH - *Athletes MH - *Athletic Performance/physiology MH - Regression Analysis PMC - PMC13372162 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/15 18:39 MHDA- 2026/07/15 18:40 PMCR- 2026/07/15 CRDT- 2026/07/15 13:43 PHST- 2025/11/19 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/15 18:40 [medline] PHST- 2026/07/15 18:39 [pubmed] PHST- 2026/07/15 13:43 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - PONE-D-25-62317 [pii] AID - 10.1371/journal.pone.0353385 [doi] PST - epublish SO - PLoS One. 2026 Jul 15;21(7):e0353385. doi: 10.1371/journal.pone.0353385. eCollection 2026. PMID- 42455466 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261008 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 93 IP - 10 DP - 2026 Oct TI - Feasibility of Enteral Nutrition in Pediatric Septic Shock at a Tertiary Center in Vietnam. PG - 1052-1057 LID - 10.1007/s12098-026-06324-4 [doi] AB - OBJECTIVES: To evaluate the feasibility and clinical characteristics of early enteral nutrition (EN), defined as initiation within 48 h of PICU admission, in children with septic shock, and to describe clinical characteristics and outcomes according to timing of EN in a resource-limited setting. METHODS: A retrospective observational study was conducted at a national tertiary pediatric intensive care unit in Vietnam. Children aged 1 mo to 16 y diagnosed with septic shock were categorized into early EN (48). Baseline characteristics, illness severity, and clinical outcomes were compared between groups. Multivariable analysis and propensity score matching were performed as exploratory approaches to adjust for confounding. RESULTS: Among 52 patients, 22 (42.3%) received early EN. Patients in the early EN group had lower baseline illness severity. Early EN was successfully implemented in a substantial proportion of patients without observed severe gastrointestinal complications. Lower mortality and more favorable outcomes, including fewer days of mechanical ventilation and reduced need for renal replacement therapy, were observed in the early EN group. However, these findings should be interpreted cautiously given the retrospective design, small sample size, and potential confounding by indication. CONCLUSIONS: Early enteral nutrition was feasible and appeared safe in children with septic shock, even in a resource-limited PICU setting. While favorable outcomes were observed, the study does not establish causality, and further prospective studies are needed to confirm these findings. CI - (c) 2026. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - Dau, Hung Viet AU - Dau HV AD - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam. FAU - Hoang, Khuyen Thi Ngoc AU - Hoang KTN AD - Center of Pediatrics, Vinmec Times City International Hospital, Hanoi, Vietnam. FAU - Ngo, Kha Manh AU - Ngo KM AD - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam. FAU - Tran, Hanh My Thi AU - Tran HMT AD - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam. FAU - Hoang, Canh Ngoc AU - Hoang CN AUID- ORCID: 0000-0003-2674-3024 AD - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam. ngocanh.nhp@gmail.com. LA - eng PT - Journal Article PT - Observational Study DEP - 20260715 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Enteral Nutrition/methods MH - Feasibility Studies MH - Intensive Care Units, Pediatric MH - Resource-Limited Settings MH - Retrospective Studies MH - Severity of Illness Index MH - *Shock, Septic/diagnosis/mortality/therapy MH - Tertiary Care Centers MH - Treatment Outcome MH - Vietnam/epidemiology OTO - NOTNLM OT - Enteral nutrition OT - Feasibility OT - Pediatric intensive care unit OT - Resource-limited settings OT - Septic shock COIS- Declarations. Conflict of Interest: None. EDAT- 2026/07/15 12:35 MHDA- 2026/10/01 05:30 CRDT- 2026/07/15 11:18 PHST- 2026/02/03 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/10/01 05:30 [medline] PHST- 2026/07/15 12:35 [pubmed] PHST- 2026/07/15 11:18 [entrez] AID - 10.1007/s12098-026-06324-4 [pii] AID - 10.1007/s12098-026-06324-4 [doi] PST - ppublish SO - Indian J Pediatr. 2026 Oct;93(10):1052-1057. doi: 10.1007/s12098-026-06324-4. Epub 2026 Jul 15. PMID- 42455187 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260922 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 15 TI - Ultrasound evaluation of quadriceps muscle thickness and body fat distribution in children receiving maintenance hemodialysis: a cross-sectional case-control study. LID - 10.1007/s00431-026-07212-x [doi] LID - 577 AB - Children on hemodialysis (HD) are at multifactorial nutritional risk. Nutritional assessment in these children is challenging because conventional anthropometric and dietary indicators are influenced by growth failure, chronic inflammation, and fluid shifts. Ultrasound (US)-based muscle assessment has emerged as a practical bedside method for evaluating muscle mass, while data on US-derived fat distribution in this population are limited. This cross-sectional case-control study was conducted at a tertiary HD center and enrolled 42 children on HD and 42 age- and sex-matched apparently healthy children. Demographic, anthropometric, clinical, and laboratory data were collected. Dietary evaluation using a 3-day food intake record was performed. Quadriceps muscle thickness, primarily that of the rectus femoris (RF), was assessed using B-mode muscle US in both groups. Subcutaneous thigh fat, anterior abdominal fat, and visceral fat thickness (VFT) were also assessed to characterize body composition. Total daily calorie intake and protein intake were significantly lower in children on HD (p < 0.001). Children on maintenance HD had significantly lower peripheral muscle thickness than healthy controls. Subcutaneous fat thickness at the thigh and abdominal wall was significantly reduced, whereas VFT was significantly increased in the HD group (p < 0.05). Correlation analysis showed that total caloric and protein intake were positively associated with muscle thickness (p < 0.001). Receiver operating characteristic (ROC) curve analysis showed that RF thickness demonstrated moderate discriminatory ability for nutritional risk, with an area under the curve (AUC) of 0.731 (p < 0.001), whereas US-derived fat measurements showed limited diagnostic performance. CONCLUSION: Quadriceps muscle US appears to be a practical adjunct and complementary assessment tool to conventional nutritional assessment in children receiving maintenance HD. US-derived subcutaneous and visceral fat measurements provide complementary information on body composition and fat distribution. WHAT IS KNOWN: * Children receiving maintenance hemodialysis are at high risk of nutritional impairment, growth failure, and altered body composition, making nutritional assessment challenging. * Ultrasound assessment of quadriceps muscle thickness is a practical bedside method for evaluating muscle mass in adults receiving hemodialysis, but pediatric evidence remains limited. WHAT IS NEW: * This study highlights the utility of bedside US measurement of quadriceps muscle thickness as a practical adjunct for detecting nutritional risk in children on maintenance HD. * This study provides novel pediatric data on US-derived subcutaneous and VFT in children on maintenance HD, revealing an altered fat distribution pattern characterized by reduced peripheral fat and increased visceral fat. CI - (c) 2026. The Author(s). FAU - Gohary, Amal E AU - Gohary AE AD - Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. amaleam@zu.edu.eg. FAU - Soliman, Azza Soliman AU - Soliman AS AD - Department of Public Health and Community Medicine, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. FAU - Eldemerdash, Sara Kamel AU - Eldemerdash SK AD - Department of Diagnostic Radiology, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. FAU - Elsharkawy, Mona Mohammed AU - Elsharkawy MM AD - Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. FAU - Gohary, Mahmoud M AU - Gohary MM AD - Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. LA - eng PT - Journal Article DEP - 20260715 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Case-Control Studies MH - Ultrasonography MH - *Quadriceps Muscle/diagnostic imaging MH - Child MH - *Renal Dialysis/adverse effects MH - *Body Fat Distribution MH - Nutrition Assessment MH - Adolescent MH - ROC Curve MH - *Kidney Failure, Chronic/therapy MH - Child, Preschool PMC - PMC13373012 OTO - NOTNLM OT - Fat distribution OT - Hemodialysis OT - Muscle ultrasound OT - Nutritional risk OT - Quadriceps muscle COIS- Declarations. Ethics approval: Following Institutional Review Board approval (ZU-IRB#751/20), this study was approved by the Pediatrics Department at Zagazig University Hospitals. Legal guardians provided informed consent. The study was conducted in accordance with the Declaration of Helsinki, which outlines ethical principles for research involving human participants. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 12:35 MHDA- 2026/07/15 12:36 PMCR- 2026/07/15 CRDT- 2026/07/15 11:04 PHST- 2026/02/07 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/15 12:36 [medline] PHST- 2026/07/15 12:35 [pubmed] PHST- 2026/07/15 11:04 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1007/s00431-026-07212-x [pii] AID - 7212 [pii] AID - 10.1007/s00431-026-07212-x [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 15;185(8):577. doi: 10.1007/s00431-026-07212-x. PMID- 42454980 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260821 IS - 1097-0193 (Electronic) IS - 1065-9471 (Print) IS - 1065-9471 (Linking) VI - 47 IP - 11 DP - 2026 Aug TI - A Discovery and Replication Study of Dyslexia Does Not Reveal Reproducible Gray Matter Volume Differences. PG - e70592 LID - 10.1002/hbm.70592 [doi] LID - e70592 AB - Two decades of research have provided evidence for gray matter volume (GMV) differences in developmental dyslexia (or reading disability, RD) in the left perisylvian cortex. However, there are concerns about result inconsistencies, likely attributable to small sample sizes, lenient statistical thresholds, and insufficient accounting for demographic variables and global GMV. To address these concerns, we conducted a Discovery and Replication Study (N = 262) using data from the Adolescent Brain Cognitive Development(SM) Study. We found GMV differences between the RD and Control Groups did not replicate across the Discovery and Replication Studies using voxel-based morphometry (VBM) in Statistical Parametric Mapping (SPM), and that a more conservative threshold yielded few results. We then conducted Reproducibility Studies and first found that when using surface-based morphometry in FreeSurfer instead of VBM, the Discovery and the Replication Study results again failed to converge. Second, we combined all groups in a factorial VBM/SPM analysis and the interaction analysis provided quantitative confirmation for diverging between-group difference results across the two studies. Third, we tested for the role of covariates of no interest and found that when total GMV is not controlled for, this divergence dissipates and group differences in RD (main effect of Reading Ability) are amplified. In conclusion, replication of GMV differences in RD is low, even when using large, well-matched groups, and analyses approaches play a modulating role. As such, results from prior studies using lenient statistical thresholds and not accounting for total GMV should be viewed with caution. CI - (c) 2026 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC. FAU - Schug, Alison K AU - Schug AK AUID- ORCID: 0000-0001-7760-0547 AD - Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia, USA. AD - Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA. FAU - Gutierrez-Schieferl, Iria S AU - Gutierrez-Schieferl IS AUID- ORCID: 0009-0001-9029-4385 AD - Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia, USA. AD - Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA. FAU - Eden, Guinevere F AU - Eden GF AUID- ORCID: 0000-0002-5942-1497 AD - Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia, USA. AD - Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA. LA - eng GR - U24 DA041147/DA/NIDA NIH HHS/United States GR - U01 DA051039/DA/NIDA NIH HHS/United States GR - U01 DA041120/DA/NIDA NIH HHS/United States GR - U01 DA041093/DA/NIDA NIH HHS/United States GR - U01 DA051038/DA/NIDA NIH HHS/United States GR - U01 DA041106/DA/NIDA NIH HHS/United States GR - U01 DA041148/DA/NIDA NIH HHS/United States GR - Z01 DA000510/ImNIH/Intramural NIH HHS/United States GR - U01 DA041174/DA/NIDA NIH HHS/United States GR - T32 DC019481/DC/NIDCD NIH HHS/United States GR - U24 DA041123/DA/NIDA NIH HHS/United States GR - U01 DA041134/DA/NIDA NIH HHS/United States GR - TL1 TR001431/NH/NIH HHS/United States GR - U01 DA041022/DA/NIDA NIH HHS/United States GR - R01 HD081078/NH/NIH HHS/United States GR - U01 DA041156/DA/NIDA NIH HHS/United States GR - U01 DA050987/DA/NIDA NIH HHS/United States GR - U01 DA051037/DA/NIDA NIH HHS/United States GR - TL1 TR001431/TR/NCATS NIH HHS/United States GR - U01 DA051016/DA/NIDA NIH HHS/United States GR - R01 HD081078/HD/NICHD NIH HHS/United States GR - U01 DA041025/DA/NIDA NIH HHS/United States GR - U01 DA050989/DA/NIDA NIH HHS/United States GR - T32 DC019481/NH/NIH HHS/United States GR - U01 DA041089/DA/NIDA NIH HHS/United States GR - U01 DA050988/DA/NIDA NIH HHS/United States GR - 1743521/National Science Foundation/ GR - U01 DA041117/DA/NIDA NIH HHS/United States GR - U01 DA041028/DA/NIDA NIH HHS/United States GR - U01 DA041048/DA/NIDA NIH HHS/United States PT - Journal Article PL - United States TA - Hum Brain Mapp JT - Human brain mapping JID - 9419065 SB - IM UOF - bioRxiv. 2026 May 07:2026.05.05.722925. doi: 10.64898/2026.05.05.722925. PMID: 42146405 MH - Humans MH - *Dyslexia/pathology/diagnostic imaging MH - *Gray Matter/pathology/diagnostic imaging MH - Magnetic Resonance Imaging MH - Reproducibility of Results MH - Female MH - Male MH - Adolescent MH - Image Processing, Computer-Assisted MH - *Brain/pathology/diagnostic imaging MH - Organ Size PMC - PMC13371619 OTO - NOTNLM OT - dyslexia OT - gray matter volume discovery and replication study OT - reading disability COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 12:37 MHDA- 2026/07/15 18:40 PMCR- 2026/07/15 CRDT- 2026/07/15 09:43 PHST- 2026/06/04 00:00 [revised] PHST- 2025/12/06 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/15 18:40 [medline] PHST- 2026/07/15 12:37 [pubmed] PHST- 2026/07/15 09:43 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - HBM70592 [pii] AID - 10.1002/hbm.70592 [doi] PST - ppublish SO - Hum Brain Mapp. 2026 Aug;47(11):e70592. doi: 10.1002/hbm.70592. PMID- 42454963 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1752-8984 (Electronic) IS - 1479-1641 (Print) IS - 1479-1641 (Linking) VI - 23 IP - 4 DP - 2026 Jul-Aug TI - Body composition rather than liver fat associates with carotid Intima-Media thickness in youth with type 1 diabetes. PG - 14791641261470422 LID - 10.1177/14791641261470422 [doi] LID - 14791641261470422 AB - IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) is a recognized cardiometabolic risk factor in adults, but its relevance to early vascular remodeling in youth with type 1 diabetes (T1D) remains unclear. We evaluated the independent associations of hepatic fat and body composition with early structural vascular remodeling in youth with T1D.MethodsThis cross-sectional study included 49 late-pubertal youth with T1D (mean age 16.1+/-2.6 years; duration 7.5+/-4.3 years). Hepatic fat was quantified using MRI-proton density fat fraction (PDFF), while body composition and estimated insulin sensitivity (eIS) were assessed using dual-energy X-ray absorptiometry and a validated pediatric equation. Carotid intima-media thickness (cIMT), measured by ultrasound, served as the primary outcome. Hierarchical linear regression assessed independent associations after adjustment for age, sex, and diabetes duration.ResultsMean hepatic fat was 1.87+/-1.22%, with no participants meeting criteria for steatosis. Hepatic fat, eIS, and diabetes duration were not associated with cIMT. Lean body mass was the primary independent associate of cIMT (beta=0.44, p=0.02). Although eIS was strongly associated with waist circumference (r=-0.76, p<0.001), neither variable was associated with cIMT.ConclusionsIn this sub-steatotic cohort, cIMT was primarily associated with lean body mass, reflecting physiologic growth, while central adiposity was associated with metabolic dysfunction but not vascular structure. FAU - Tas, Emir AU - Tas E AUID- ORCID: 0000-0003-3759-2778 AD - Pediatric Endocrinology and Diabetes, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Gumus, Memduha AU - Gumus M AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 AD - Pediatric Radiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. FAU - Movva, Swetha AU - Movva S AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Mendizabal, Brenda AU - Mendizabal B AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 AD - Pediatric Cardiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. FAU - Barinas-Mitchell, Emma AU - Barinas-Mitchell E AD - Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Gong, Zhenwei AU - Gong Z AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Dranoff, Jonathan A AU - Dranoff JA AD - Department of Medicine, Yale University, New Haven, CT, USA. RINGGOLD: 12228 AD - Steatotic Liver Disease Program, VA Connecticut Healthcare System, New Haven, CT, USA. RINGGOLD: 628143 FAU - Muzumdar, Radhika AU - Muzumdar R AD - Pediatric Endocrinology and Diabetes, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Libman, Ingrid AU - Libman I AD - Pediatric Endocrinology and Diabetes, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 LA - eng PT - Journal Article DEP - 20260715 PL - England TA - Diab Vasc Dis Res JT - Diabetes & vascular disease research JID - 101234011 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/diagnosis/complications/physiopathology MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - Male MH - *Carotid Intima-Media Thickness MH - *Adiposity MH - *Liver/diagnostic imaging/physiopathology MH - Insulin Resistance MH - *Carotid Artery Diseases/diagnostic imaging/etiology/physiopathology MH - Risk Factors MH - *Vascular Remodeling MH - Age Factors MH - Absorptiometry, Photon MH - Magnetic Resonance Imaging MH - Child MH - *Fatty Liver/physiopathology/diagnostic imaging MH - *Body Composition MH - Predictive Value of Tests PMC - PMC13373370 OTO - NOTNLM OT - MRI-PDFF OT - adiposity OT - body composition OT - carotid intima-media thickness OT - insulin resistance OT - type 1 diabetes COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/15 12:37 MHDA- 2026/07/15 12:38 PMCR- 2026/07/15 CRDT- 2026/07/15 09:33 PHST- 2026/07/15 12:38 [medline] PHST- 2026/07/15 12:37 [pubmed] PHST- 2026/07/15 09:33 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1177_14791641261470422 [pii] AID - 10.1177/14791641261470422 [doi] PST - ppublish SO - Diab Vasc Dis Res. 2026 Jul-Aug;23(4):14791641261470422. doi: 10.1177/14791641261470422. Epub 2026 Jul 15. PMID- 42453669 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Impact of metabolic score for visceral fat on bone health in adolescent population: a cross-sectional study perspective. PG - 1822235 LID - 10.3389/fnut.2026.1822235 [doi] LID - 1822235 AB - OBJECTIVE: To analyze the relationship between the Metabolic Score for Visceral Fat (METS-VF), bone mineral content (BMC), and bone metabolism indexes in Chinese adolescents. METHODS: This cross-sectional study used stratified cluster sampling to select 1,206 adolescents (12-18 years) from six schools in Yinchuan (2017-2023). Body composition and BMC of the participants were measured using bioelectrical impedance analysis (BIA). Serum bone metabolism indexes [osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX)] were measured. RESULTS: METS-VF was found to be associated with BMC (r = 0.484, P < 0.001) and OC (r = -0.074, P = 0.010), but not with CTX (r = 0.042, P = 0.141). After adjusting for confounding factors, compared with the lowest quartile of METS-VF, the risk of low BMC in the highest quartile was significantly lower, with an OR of 0.17 (95% CI: 0.05-0.49), whereas the risk of low OC was significantly higher, with an OR of 3.47 (95% CI: 1.82-6.59) (all P < 0.05). In sex-stratified analyses, this association was significant in both boys and girls (OR(boys) = 0.03, 95% CI: 0.01-0.46, P = 0.007; OR(girls) = 0.20, 95% CI: 0.06-0.64, P = 0.005). Restricted cubic spline curves indicated that there was an inverted U-shaped non-linear relationship between METS-VF and BMC (P-overall = 0.002, P-nonlinear = 0.009). In sex-stratified analyses, the association was significant in girls (P-nonlinear = 0.152; P-overall = 0.008); Moreover, linear relationship between METS-VF and OC were found (P nonlinear = 0.162, P-overall <0.05). Receiver operating characteristic (ROC) curves showed that METS-VF had modest discriminatory ability for low BMC better than VAI and TyG (AUC = 0.641, 95% CI = 0.605-0.678, P < 0.05). CONCLUSION: Our findings suggest a non-linear association between METS-VF and BMC in adolescents, and fat distribution and content were more closely related to bone metabolism. CI - Copyright (c) 2026 Chen, Liu, Shi, Xu and Ding. FAU - Chen, Linlin AU - Chen L AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. FAU - Liu, Jianxi AU - Liu J AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. FAU - Shi, Longkai AU - Shi L AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. FAU - Xu, Yingli AU - Xu Y AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. FAU - Ding, Wenqing AU - Ding W AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. LA - eng PT - Journal Article DEP - 20260630 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13365040 OTO - NOTNLM OT - adolescents OT - bone metabolism markers OT - bone mineral content OT - osteoporosis OT - the metabolic score for visceral fat COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/15 10:10 MHDA- 2026/07/15 10:11 PMCR- 2026/06/30 CRDT- 2026/07/15 04:50 PHST- 2026/03/03 00:00 [received] PHST- 2026/05/31 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/15 10:11 [medline] PHST- 2026/07/15 10:10 [pubmed] PHST- 2026/07/15 04:50 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.3389/fnut.2026.1822235 [doi] PST - epublish SO - Front Nutr. 2026 Jun 30;13:1822235. doi: 10.3389/fnut.2026.1822235. eCollection 2026. PMID- 42453435 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260922 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical activity and adolescents' parasocial relationships with virtual idols: evidence from loneliness, gender differences, and network analysis. PG - 1854829 LID - 10.3389/fpsyg.2026.1854829 [doi] LID - 1854829 AB - INTRODUCTION: This study aimed to examine whether higher levels of physical activity were associated with adolescents' parasocial relationships with virtual idols through lower levels of loneliness, and to determine whether gender moderated these associations. The study also explored the item-level connections between loneliness and parasocial relationships with virtual idols. METHODS: A cross-sectional survey was conducted among 2,798 adolescents from Sichuan, Hunan, Yunnan, and Chongqing provinces in China. Physical activity, loneliness, and parasocial relationships with virtual idols were measured using validated questionnaires. The SPSS PROCESS macro was used to test the moderated mediation model, and network analysis was conducted to identify key bridging nodes between loneliness and parasocial relationships. RESULTS: Physical activity was significantly negatively associated with parasocial relationships with virtual idols, and loneliness showed a significant partial statistical mediation in this association. Gender significantly moderated both the association between physical activity and loneliness and the association between loneliness and parasocial relationships, with these associations being more pronounced among female adolescents. Network analysis further identified bridging connections between real-life relational deficits, such as feeling neglected and lacking companionship, and emotional involvement with virtual idols, such as caring about the life of a virtual idol. DISCUSSION: The findings suggest that physical activity may be associated with weaker parasocial relationships with virtual idols not only through time occupation or attention diversion, but also through lower loneliness and stronger real-life social connection. Interventions aimed at reducing excessive emotional dependence on virtual idols should therefore focus on promoting physical engagement, real-life interaction, and adolescents' sense of belonging. CI - Copyright (c) 2026 Chen, Lin, Wang, Wang and Xiang. FAU - Chen, Longjiang AU - Chen L AD - Institute of Physical Education, Yunnan Normal University, Kunming, China. FAU - Lin, Ziyang AU - Lin Z AD - School of Sport and Art, Shenzhen Technology University, Shenzhen, China. FAU - Wang, Zeyan AU - Wang Z AD - School of Physical Education, Chengdu University of Technology, Chengdu, China. FAU - Wang, Jiale AU - Wang J AD - College of Physical Education, Xinjiang Normal University, Urumqi, Xinjiang, China. FAU - Xiang, Yian AU - Xiang Y AD - Department of Rehabilitation Medicine, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China. LA - eng PT - Journal Article DEP - 20260630 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13365051 OTO - NOTNLM OT - adolescents OT - loneliness OT - network analysis OT - parasocial relationship OT - physical activity OT - virtual idols COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/15 06:38 MHDA- 2026/07/15 06:39 PMCR- 2026/06/30 CRDT- 2026/07/15 04:47 PHST- 2026/04/13 00:00 [received] PHST- 2026/06/07 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/07/15 06:39 [medline] PHST- 2026/07/15 06:38 [pubmed] PHST- 2026/07/15 04:47 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1854829 [doi] PST - epublish SO - Front Psychol. 2026 Jun 30;17:1854829. doi: 10.3389/fpsyg.2026.1854829. eCollection 2026. PMID- 42453080 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1525-1446 (Electronic) IS - 0737-1209 (Print) IS - 0737-1209 (Linking) VI - 43 IP - 5 DP - 2026 Sep-Oct TI - The Urban-Rural Continuum and Child Health: Influence of Residential Location on Ultra-Processed Food Consumption, Physical Activity, and Metabolic Biomarkers. PG - 1180-1189 LID - 10.1111/phn.70156 [doi] AB - OBJECTIVE: This study aimed to investigate the association between residential location-urban area and urban expansion area and sociodemographic characteristics, health behaviors, and clinical-metabolic outcomes among schoolchildren aged 6 to 9 years in the municipality of Rio das Ostras, Brazil. METHODS: This was a cross-sectional study involving 420 students from public municipal schools. Sociodemographic and behavioral data were collected using validated questionnaires (QUADA-3 and QUAFDA). Anthropometric measurements, blood pressure, and biochemical analyses were conducted. Associations were assessed using Pearson's chi-square or Fisher's exact tests and logistic regression models, both crude and adjusted for age, sex, maternal and paternal education, and household income.were estimated with 95% confidence intervals (CI). FINDINGS: Children living in urban expansion areas had lower paternal education levels (p = 0.021) and were less likely to engage in active commuting to school (2.4% vs. 42.6%; p < 0.001). No significant differences were observed in excess weight, physical activity scores, or ultra-processed food consumption between the two groups. However, children from urban expansion areas showed a higher prevalence of prediabetes (OR = 0.133; 95% CI = 0.045-0.358; p < 0.001), elevated total cholesterol (OR = 0.423; p = 0.007), low HDL-c (OR = 0.324; p < 0.001), elevated LDL-c (OR = 0.304; p < 0.001), and elevated triglycerides (OR = 0.484; p = 0.029). CONCLUSIONS: Residing in urban expansion areas was associated with worse clinical-metabolic outcomes among schoolchildren, independent of nutritional status, physical activity, and ultra-processed food consumption. These findings highlight the need for intersectoral and place-based policies to promote healthier environments for children in territories undergoing urbanization. CI - (c) 2026 The Author(s). Public Health Nursing published by Wiley Periodicals LLC. FAU - Rangel, Luiz Felipe da Cruz AU - Rangel LFDC AUID- ORCID: 0000-0001-5513-0011 AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. AD - Higher Institutes of Education of CENSA, ISECENSA, Campos dos Goytacazes, Brazil. FAU - Silva, Cynthia Goncalves AU - Silva CG AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. FAU - de Matos, Alessandra Alegre AU - de Matos AA AUID- ORCID: 0000-0001-7938-4198 AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. FAU - Teixeira, Francisco Martins AU - Teixeira FM AUID- ORCID: 0000-0003-0640-5570 AD - Macae Campus, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Ribeiro, Beatriz Goncalves AU - Ribeiro BG AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. AD - Macae Campus, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20260715 PL - United States TA - Public Health Nurs JT - Public health nursing (Boston, Mass.) JID - 8501498 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Brazil MH - Cross-Sectional Studies MH - *Urban Population/statistics & numerical data MH - *Rural Population/statistics & numerical data MH - *Exercise MH - *Child Health/statistics & numerical data MH - Biomarkers/blood/analysis MH - *Fast Foods/statistics & numerical data MH - *Residence Characteristics/statistics & numerical data MH - Health Behavior MH - Socioeconomic Factors PMC - PMC13535876 OTO - NOTNLM OT - child health OT - health inequalities OT - pediatric dyslipidemia OT - physical activity OT - ultra-processed foods OT - urbanization EDAT- 2026/07/15 06:37 MHDA- 2026/09/02 11:39 PMCR- 2026/09/02 CRDT- 2026/07/15 04:42 PHST- 2025/11/05 00:00 [revised] PHST- 2025/09/03 00:00 [received] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/09/02 11:39 [medline] PHST- 2026/07/15 06:37 [pubmed] PHST- 2026/07/15 04:42 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - PHN70156 [pii] AID - 10.1111/phn.70156 [doi] PST - ppublish SO - Public Health Nurs. 2026 Sep-Oct;43(5):1180-1189. doi: 10.1111/phn.70156. Epub 2026 Jul 15. PMID- 42452888 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - A Growing Problem: Increases in Child-Appealing Marketing on Infant and Young Children's Foods in Australia (2015 vs 2024). PG - e70226 LID - 10.1111/mcn.70226 [doi] LID - e70226 AB - Commercial foods for infants and young children are widely available and often introduced early, including before 6 months, raising concerns about their often high levels of sugar and sodium, limited micronutrient content, and sweet flavours that may shape future taste preferences. Product packaging further influences caregiver choices through child-appealing images and claims. This study examined changes in child-appealing marketing appearing on packaged commercial infant and young children's foods available in Australia in 2015 (n = 311) and 2024 (n = 298). Products were coded using a validated framework comprising 11 core techniques (child-targeted, e.g., bright colours, cartoon characters, fun themes) and 9 broad techniques (caregiver-targeted, e.g., nutrition/health, texture claims). Marketing power was calculated as the sum of techniques per product. The proportion of products featuring child-appealing marketing increased from 73.0% in 2015 to 89.9% in 2024, with significant increases in appeals to fun (48.2% to 79.2%), branded characters (33.8% to 62.4%), and child-appealing visuals on the package (60.5% to 72.5%). Claims regarding texture were high in both years (99.7% in 2015 and 100.0% in 2024), and there was a notable growth in messages promoting value, convenience, or sustainability (from 50.2% to 62.1%). Marketing power scores rose significantly over time, indicating an intensification of persuasive techniques on packaging. These findings highlight systemic commercial strategies that promote nutritionally poor foods to infants, young children and caregivers, undermining public health efforts. Stronger, government-led regulation is urgently needed to address the widespread use of both child-targeted and caregiver-targeted marketing on commercial foods for infants and young children. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Arfines, Prisca Petty AU - Arfines PP AUID- ORCID: 0000-0002-5118-7536 AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - Coyle, Daisy AU - Coyle D AUID- ORCID: 0000-0001-8904-0671 AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - Barrett, Eden AU - Barrett E AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - McCann, Jennifer AU - McCann J AUID- ORCID: 0000-0002-8940-978X AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Dunford, Elizabeth AU - Dunford E AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. AD - Department of Nutrition, Gillings Global School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Jones, Alexandra AU - Jones A AUID- ORCID: 0000-0001-5039-144X AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Australia MH - Infant MH - *Infant Food MH - *Marketing/trends/methods MH - *Food Preferences MH - Child, Preschool MH - *Food Labeling MH - Food Packaging MH - Nutritive Value MH - Female MH - *Consumer Behavior PMC - PMC13369571 OTO - NOTNLM OT - food analysis OT - food labelling OT - food packaging OT - infant food OT - marketing OT - nutrition labelling OT - processed food COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:34 MHDA- 2026/07/15 12:36 PMCR- 2026/07/14 CRDT- 2026/07/15 02:04 PHST- 2026/04/13 00:00 [revised] PHST- 2026/01/22 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/15 12:36 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 02:04 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - MCN70226 [pii] AID - 10.1111/mcn.70226 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70226. doi: 10.1111/mcn.70226. PMID- 42452565 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 13 DP - 2026 Jun 30 TI - Presentation and Clinical Outcomes of Inflammatory Bowel Disease in Children and Adolescents at a Tertiary Care Center in Lebanon. LID - 10.3390/jcm15135105 [doi] LID - 5105 AB - Background: Pediatric-onset inflammatory bowel disease (IBD) is a chronic relapsing condition leading to substantial morbidity and variable disease course. Early recognition of factors associated with suboptimal outcomes may improve risk stratification and therapeutic strategy. This retrospective cohort study intended to analyze the association between initial presentation characteristics and early disease course in pediatric-onset IBD. Methods: Included were pediatric patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) followed at the American University of Beirut Medical Center between 2013 and 2023. Demographic, anthropometric, laboratory, endoscopic, radiologic, and clinical data were gathered from medical records. Validated pediatric activity indices were used to assess severity, and early outcomes covered mainly the first remission. Results: Eighty-eight patients were evaluated for baseline characteristics, and eighty-one patients were analyzed for treatment outcomes. Among 88 subjects, 62.5% had CD and 37.5% had UC, with a mean age at diagnosis of 11.29 (+/-4.60) years. The most encountered presenting symptoms were abdominal pain, diarrhea, and hematochezia, with 44.9% of subjects having malnutrition. Clinical remission after initial treatment was obtained in 60.2% of subjects. A past medical history of autoimmune or inflammatory disease was linked to persistent symptoms, whereas initial use of corticosteroids was associated with early clinical remission. Conclusions: Pediatric IBD in our cohort was marked by extensive disease involvement, high inflammatory burden, nutritional impairment, and frequent flare or treatment escalation. Corticosteroid initiation at diagnosis was associated with early clinical remission in this retrospective cohort. Nevertheless, this association should be interpreted cautiously, as the retrospective design and potential confounding by indication limit any inference regarding causality or treatment superiority. The high rate of subsequent flare underscores the need for early risk stratification and individualized multidisciplinary care to improve long-term outcomes. FAU - Daoud, Tracy AU - Daoud T AD - Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut 1107, Lebanon. FAU - Khafaja, Sarah AU - Khafaja S AD - Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut 1107, Lebanon. FAU - Hanna-Wakim, Rima AU - Hanna-Wakim R AUID- ORCID: 0000-0002-8870-2159 AD - Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut 1107, Lebanon. AD - Division of Pediatric Infectious Diseases, Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut 1107, Lebanon. FAU - Yazbeck, Nadine AU - Yazbeck N AUID- ORCID: 0000-0002-2325-4113 AD - Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut 1107, Lebanon. AD - Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut 1107, Lebanon. LA - eng PT - Journal Article DEP - 20260630 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13362712 OTO - NOTNLM OT - Crohn's disease OT - clinical remission OT - disease severity OT - pediatric inflammatory bowel disease OT - ulcerative colitis COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 10:10 MHDA- 2026/07/15 10:11 PMCR- 2026/06/30 CRDT- 2026/07/15 01:09 PHST- 2026/05/19 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/07/15 10:11 [medline] PHST- 2026/07/15 10:10 [pubmed] PHST- 2026/07/15 01:09 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - jcm15135105 [pii] AID - jcm-15-05105 [pii] AID - 10.3390/jcm15135105 [doi] PST - epublish SO - J Clin Med. 2026 Jun 30;15(13):5105. doi: 10.3390/jcm15135105. PMID- 42451409 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 13 DP - 2026 Jul 2 TI - A Multi-Stage Framework for Refining Infant Daytime Sleep-Wake Labels from Wearable Accelerometer Data. LID - 10.3390/s26134168 [doi] LID - 4168 AB - Sleep is essential for infants' physical and cognitive development. Unlike older children or adolescents, infants sleep longer durations, including multiple daytime naps. While nighttime sleep is easier to detect due to its extended periods, identifying daytime sleep is more challenging due to its short, fragmented nature and its similarity to idle wakefulness. Moreover, parent-reported sleep estimations are prone to error as continuous monitoring is often impractical. To address these limitations, we developed a Multi-Stage Sleep-Wake (MSW) classification approach using triaxial accelerometer data collected from wearable devices placed on infants' ankles and waists over multiple days. This method systematically refines and classifies sleep and wake states through a series of analytical steps. This systematic process generates refined proxy sleep-wake labels that account for behavioral overlaps and correct mislabeled idle periods. We trained and validated multiple machine learning models using these labels and compared the results to parent annotated labels. Models trained using MSW-derived labels achieved 96.6% accuracy using Random Forest classifier compared to 72% using parent-reported labels. These findings demonstrate that the MSW framework produces a more consistent set of proxy sleep-wake annotations for model development, although the derived labels were not validated against an independent reference standard. Furthermore, the proposed MSW framework may serve as a practical label-refinement methodology for improving noisy caregiver-reported sleep annotations in future wearable-based infant sleep studies where independent sleep labels are unavailable. FAU - Thelagathoti, Rama Krishna AU - Thelagathoti RK AD - Molecular Diagnostic Research Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA. FAU - Redrowthu, Vijaya Saraswathi AU - Redrowthu VS AUID- ORCID: 0000-0002-5462-3030 AD - Department of Computer Science and Engineering, VNR Vignana Jyothi Institute of Engineering and Technology, Hyderabad 500090, Telangana, India. FAU - Dinkel, Danae AU - Dinkel D AUID- ORCID: 0000-0002-0262-4429 AD - School of Health and Kinesiology, University of Nebraska Omaha, Omaha, NE 68182, USA. FAU - Ali, Hesham H AU - Ali HH AUID- ORCID: 0000-0002-8016-6144 AD - College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE 68182, USA. FAU - Fernando, Rohan M AU - Fernando RM AUID- ORCID: 0000-0002-3596-3160 AD - Molecular Diagnostic Research Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA. LA - eng GR - PG64311/Ryan Foundation/ PT - Journal Article DEP - 20260702 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Wearable Electronic Devices MH - Infant MH - *Accelerometry/methods MH - *Wakefulness/physiology MH - *Sleep/physiology MH - Machine Learning MH - Female MH - Male PMC - PMC13363950 OTO - NOTNLM OT - actigraphy data analysis OT - infant sleep detection OT - label refinement OT - wearable accelerometers COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:34 MHDA- 2026/07/15 13:09 PMCR- 2026/07/02 CRDT- 2026/07/15 01:06 PHST- 2026/04/24 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/06/27 00:00 [accepted] PHST- 2026/07/15 13:09 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 01:06 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - s26134168 [pii] AID - sensors-26-04168 [pii] AID - 10.3390/s26134168 [doi] PST - epublish SO - Sensors (Basel). 2026 Jul 2;26(13):4168. doi: 10.3390/s26134168. PMID- 42451245 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 13 DP - 2026 Jun 24 TI - Automated Anxiety Detection System Integrating a Brain-Computer Interface for Neurofeedback Applications. LID - 10.3390/s26134004 [doi] LID - 4004 AB - Anxiety disorders pose an increasing challenge to the mental health of individuals, particularly in regions with limited healthcare access. This study investigated the potential of integrating a brain-computer interface for processing electroencephalography (EEG) data with deep learning models to accurately classify anxious and non-anxious states. In the first phase, a convolutional neural network (CNN) was developed and validated on the public GAMEEMO dataset, achieving a classification accuracy of 95.72%. In the second phase, we conducted a separate experimental validation with seven participants (aged 18-60 years) using a within-subjects design. The protocol comprised a custom Stroop test to elicit acute cognitive stress and anxiety-related arousal, followed by a guided 4-7-8 breathing exercise to induce relaxation. EEG data from this experiment were used to classify anxious versus non-anxious states with the same CNN architecture after domain adaptation. On this self-collected dataset, the CNN achieved an accuracy of 86.58%. These results demonstrate proof-of-concept transferability while highlighting the performance gap between controlled benchmark data and real-world, small-sample recordings. The deep learning model can subsequently be coupled with neurofeedback techniques to manage anxiety levels. Overall, the findings support the potential of the developed automated system for detecting stress-induced anxious states, with possible future integration into neurofeedback-based management systems. FAU - Aldayel, Mashael AU - Aldayel M AUID- ORCID: 0000-0001-6054-4534 AD - Information Technology Department, College of Computer and Information Sciences, King Saud University, Riyadh 11543, Saudi Arabia. FAU - Al-Nafjan, Abeer AU - Al-Nafjan A AUID- ORCID: 0000-0003-4186-9805 AD - Computer Science Department, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia. LA - eng GR - IMSIU-DDRSP2604/Imam Mohammad ibn Saud Islamic University/ PT - Journal Article DEP - 20260624 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Brain-Computer Interfaces MH - Electroencephalography/methods MH - *Neurofeedback/methods MH - Convolutional Neural Networks MH - Adult MH - *Anxiety/diagnosis/physiopathology MH - Middle Aged MH - Female MH - Deep Learning MH - Male MH - Adolescent MH - Young Adult PMC - PMC13363975 OTO - NOTNLM OT - anxiety OT - brain-computer interface OT - deep learning OT - electroencephalography OT - neurofeedback COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:35 MHDA- 2026/07/15 13:09 PMCR- 2026/06/24 CRDT- 2026/07/15 01:05 PHST- 2026/04/03 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/15 13:09 [medline] PHST- 2026/07/15 06:35 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - s26134004 [pii] AID - sensors-26-04004 [pii] AID - 10.3390/s26134004 [doi] PST - epublish SO - Sensors (Basel). 2026 Jun 24;26(13):4004. doi: 10.3390/s26134004. PMID- 42451177 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jul 4 TI - Trans Fatty Acids Content in Breast Milk as a Marker of Their Short-Term Intake Within the Breastfeeding Mother's Diet: A Single-Participant Pilot Study. LID - 10.3390/nu18132177 [doi] LID - 2177 AB - Introduction: Breast milk is the best food for a growing infant during the first 6 months of life. The presence of trans fatty acids (TFAs) in breast milk can interfere with the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), increasing the risk of developing, among other issues, asthma or atopic dermatitis. TFAs are not synthesised de novo in the human body. Their content in breast milk may be a good marker of short-term dietary intake of these compounds by breastfeeding mothers. However, the literature shows differences in the assessment of the relationship between dietary TFAs intake and TFAs content in breast milk. Furthermore, the decrease in the TFAs content in food observed recently seems to make it impossible to use Craig-Schmidt's formula to estimate the TFAs content in the diet or in breast milk. The aim of this study was to confirm the possibility of using TFAs content in breast milk as a marker of their short-term intake within the breastfeeding mother's diet, together with an attempt at preliminary quantitative determination of the relationship between these parameters. Materials: The study material was collected from a single breastfeeding mother and included 10 breast milk samples and 10 samples of daily food rations reconstructed based on the 24 h food consumption survey. Methods: The content of fatty acids, including TFAs, was determined by gas chromatography-mass spectrometry (GC-MS). Results: The TFAs content in the whole-day mother's diet and in 100 mL of breast milk ranged from 0.11 to 0.54 g/day and from 0.02 to 0.07 g, respectively. A strong statistically significant (p < 0.05) positive correlation between these parameters was found. Equations for an exploratory linear relationship between the TFAs content in a breastfeeding mother's diet and the concentration of these fatty acids in breast milk have been developed. Due to the small number of samples, these data should be interpreted very cautiously and validated in a larger cohort. Conclusions: This single-participant pilot study suggests that TFAs content in breast milk may be a marker of the dietary intake of these compounds from the previous day. It seems that the dietary habits of breastfeeding mothers of twins are a significant factor influencing the composition of breast milk and, consequently, the nutritional quality of breastfed infants. FAU - Jasinska-Melon, Edyta AU - Jasinska-Melon E AUID- ORCID: 0000-0003-1697-5462 AD - Department of Nutrition and Nutritive Value of Food, National Institute of Public Health NIH-National Research Institute, Chocimska Str. 24, 00-791 Warsaw, Poland. FAU - Mojska, Hanna AU - Mojska H AUID- ORCID: 0000-0002-4093-6159 AD - Department of Nutrition and Nutritive Value of Food, National Institute of Public Health NIH-National Research Institute, Chocimska Str. 24, 00-791 Warsaw, Poland. FAU - Bzikowska-Jura, Agnieszka AU - Bzikowska-Jura A AUID- ORCID: 0000-0001-5181-3771 AD - Department of Clinical Dietetics, Faculty of Health Sciences, Medical University of Warsaw, Ciolka Str. 27, 01-445 Warsaw, Poland. LA - eng GR - 1/FZML/2023 and S.1.FZ.2.26/National Institute of Public Health NIH-National Research Institute/ PT - Journal Article DEP - 20260704 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (Trans Fatty Acids) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - Female MH - Pilot Projects MH - *Breast Feeding MH - Biomarkers/analysis MH - *Trans Fatty Acids/analysis MH - *Diet MH - Adult MH - Infant PMC - PMC13363609 OTO - NOTNLM OT - GC-MS OT - a 10-day reconstructed daily diet OT - breast milk OT - breastfeeding twins OT - correlations OT - trans fatty acids COIS- The authors declare no conflict of interest. EDAT- 2026/07/15 06:35 MHDA- 2026/07/15 18:40 PMCR- 2026/07/04 CRDT- 2026/07/15 01:05 PHST- 2026/05/15 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/15 18:40 [medline] PHST- 2026/07/15 06:35 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - nu18132177 [pii] AID - nutrients-18-02177 [pii] AID - 10.3390/nu18132177 [doi] PST - epublish SO - Nutrients. 2026 Jul 4;18(13):2177. doi: 10.3390/nu18132177. PMID- 42451141 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260817 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jul 2 TI - Real-World Use, Prescribing Patterns, and Short-Term Clinical Evolution of Extensively Hydrolyzed and Hydrolyzed Rice Formulas in Infants with Cow's Milk Protein Allergy: An Analysis from the ETAPA Project. LID - 10.3390/nu18132137 [doi] LID - 2137 AB - Background: Hydrolyzed rice formulas (HRFs) are increasingly recognized as an alternative nutritional option for infants with cow's milk protein allergy (CMPA), but real-world data on prescribing patterns and early clinical evolution remain limited. Objective: This study aimed to describe real-world use and prescribing patterns of HRF and eHF in infants with CMPA, identify factors associated with HRF recommendation, and assess short-term clinical evolution after formula use. Methods: This observational analysis from the ETAPA project included two mutually exclusive infant-level cohorts: a prospective recommendation cohort assessing variables associated with HRF versus eHF recommendation, and a retrospective treated cohort assessing 7-day clinical evolution after formula use. In the retrospective cohort, the main clinical outcome was absolute change in CoMiSS from day 0 to day 7. A propensity score-weighted sensitivity analysis was performed to address measured confounding by indication. Results: Overall, 1505 valid infant-level records were analyzed: 1094 in the prospective cohort and 411 in the retrospective cohort. In the prospective cohort, HRF was recommended in 214/1094 records (19.6%). In multi-variable analysis, older infant age was associated with higher odds of HRF recommendation (OR 1.034 per month, 95% CI 1.002-1.067; p = 0.036), whereas IgE-mediated CMPA was associated with lower odds (OR 0.673, 95% CI 0.459-0.988; p = 0.043). In the retrospective cohort, CoMiSS decreased markedly in both groups (eHF: median reduction 7.0 [IQR 4.0-10.0] points; HRF: 6.5 [4.0-10.0] points; p = 0.661). After adjustment, HRF was not associated with a statistically significant difference in absolute CoMiSS reduction compared with eHF (beta -0.513 points, 95% CI -1.108 to 0.082; p = 0.091). Conclusions: In routine pediatric practice, HRF was used across a broad range of CMPA profiles and was associated with clinically relevant short-term symptom improvement. These findings support HRF as an additional nutritional option for CMPA management, while the observational design precludes conclusions of equivalence or non-inferiority versus eHF. FAU - Diaz-Martin, Juan Jose AU - Diaz-Martin JJ AUID- ORCID: 0000-0003-0962-8403 AD - Unit of Pediatric Gastroenterology and Nutrition, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain. FAU - Martin-Masot, Rafael AU - Martin-Masot R AD - Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 29010 Malaga, Spain. FAU - Santamaria-Orleans, Alicia AU - Santamaria-Orleans A AD - Medical Department, Laboratorios Ordesa S.L., 08038 Barcelona, Spain. FAU - Navas-Lopez, Victor Manuel AU - Navas-Lopez VM AUID- ORCID: 0000-0003-3004-252X AD - Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, 29010 Malaga, Spain. LA - eng GR - Etapa Project 2024/Laboratorios Ordesa S.L./ PT - Journal Article PT - Observational Study DEP - 20260702 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Milk Proteins) RN - 0 (Protein Hydrolysates) SB - IM MH - Humans MH - *Milk Hypersensitivity/diet therapy MH - *Oryza MH - *Infant Formula MH - Infant MH - Retrospective Studies MH - Female MH - Male MH - *Milk Proteins/immunology/adverse effects MH - Prospective Studies MH - *Practice Patterns, Physicians'/statistics & numerical data MH - *Protein Hydrolysates MH - Hydrolysis MH - Animals MH - Cattle PMC - PMC13363393 OTO - NOTNLM OT - CoMiSS OT - cow's milk protein allergy OT - extensively hydrolyzed formula OT - hydrolyzed rice formula OT - infants OT - nutritional management OT - prescribing patterns OT - real-world evidence COIS- A.S.-O. is an employee of Laboratorios Ordesa S.L., which funded the ETAPA project and manufactures the formulas evaluated in this analysis. The remaining authors declare no conflicts of interest. EDAT- 2026/07/15 06:35 MHDA- 2026/07/15 18:40 PMCR- 2026/07/02 CRDT- 2026/07/15 01:05 PHST- 2026/05/29 00:00 [received] PHST- 2026/06/25 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/15 18:40 [medline] PHST- 2026/07/15 06:35 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - nu18132137 [pii] AID - nutrients-18-02137 [pii] AID - 10.3390/nu18132137 [doi] PST - epublish SO - Nutrients. 2026 Jul 2;18(13):2137. doi: 10.3390/nu18132137. PMID- 42451103 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jun 27 TI - Health-Related Quality of Life in Pediatric Hepatic Glycogen Storage Disease: A Dual-Perspective Study. LID - 10.3390/nu18132099 [doi] LID - 2099 AB - Background/Objectives: Hepatic glycogen storage diseases (GSDs) are rare inherited metabolic disorders requiring lifelong nutritional management and strict metabolic control, which may adversely affect the health-related quality of life (HRQoL). This study aimed to evaluate the HRQoL in children with hepatic GSD using both child and parent reports, compare findings with normative data, and explore associations with biochemical, anthropometric, and nutritional management-related parameters. Methods: The study included 23 children with hepatic GSD and their parents. HRQoL was assessed using the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scale. Child and parent reports were compared with normative data for healthy and chronically ill children. Agreement between child and parent reports was evaluated with intraclass correlation coefficients, and exploratory associations between variables were assessed using partial Spearman correlation analyses. Results: Total and most subscale PedsQL scores reported by both children and parents were significantly lower than those of healthy peers and children with chronic diseases (p < 0.05). Parents reported lower HRQoL scores than children, particularly in psychosocial, social, and school functioning domains, with low to moderate agreement between reports. Exploratory analyses suggested that body composition and nutritional treatment burden indicators were correlated with selected HRQoL domains. Conclusions: Children with hepatic GSD experience impaired HRQoL from both child and parent perspectives. Integrating HRQoL assessment into routine clinical and nutritional follow-up may help identify unmet psychosocial and dietary support needs and support more individualized nutritional management in children with hepatic GSD. FAU - Aydin, Oznur AU - Aydin O AUID- ORCID: 0000-0001-8463-6660 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkiye. FAU - Dagdelen, Selcuk AU - Dagdelen S AUID- ORCID: 0000-0002-0513-1750 AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkiye. FAU - Ozen, Hasan AU - Ozen H AUID- ORCID: 0000-0002-9063-3893 AD - Division of Pediatrics, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkiye. FAU - Gokmen-Ozel, Hulya AU - Gokmen-Ozel H AUID- ORCID: 0000-0002-8282-6468 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkiye. LA - eng GR - 2211/A/Turkiye Bilimsel ve Teknolojik Arastirma Kurumu/ PT - Journal Article DEP - 20260627 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Hepatorenal form of glycogen storage disease SB - IM MH - Humans MH - *Quality of Life MH - Male MH - Female MH - Child MH - Parents/psychology MH - Child, Preschool MH - *Glycogen Storage Disease/psychology MH - Adolescent MH - Nutritional Status MH - *Glycogen Storage Disease Type I/psychology PMC - PMC13364485 OTO - NOTNLM OT - body composition OT - nutritional management OT - parent-proxy report OT - pediatric quality of life inventory OT - uncooked cornstarch COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:36 MHDA- 2026/07/15 18:42 PMCR- 2026/06/27 CRDT- 2026/07/15 01:05 PHST- 2026/05/22 00:00 [received] PHST- 2026/06/21 00:00 [revised] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 06:36 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/27 00:00 [pmc-release] AID - nu18132099 [pii] AID - nutrients-18-02099 [pii] AID - 10.3390/nu18132099 [doi] PST - epublish SO - Nutrients. 2026 Jun 27;18(13):2099. doi: 10.3390/nu18132099. PMID- 42451061 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jun 24 TI - Potential of Breast Milk Exosomes in Modulating Infant Developmental Programming: A Multi-Omics Study Based on a Birth Cohort. LID - 10.3390/nu18132058 [doi] LID - 2058 AB - BACKGROUND: Human breast milk (HBM), as the initial food for humans, is quite essential for infant development and also for health throughout the lifespan. Exosomes are bioactive components in HBM, yet their nutritional role remains poorly recognized. OBJECTIVES: This study investigates how HBM exosomes change with lactation and their potential role in infant growth and development. METHODS: HBM samples were obtained at 2 and 6 months postpartum from a well-established birth cohort. Purified exosomes were detected using transcriptomic, lipidomic, and proteomic approaches. Then, multi-omics data were analyzed to compare differentially expressed miRNAs, lipids, and proteins along with different lactation periods and their association with the infant growth process. RESULTS: Compared with the 2-month postpartum group, the expression levels of miR-214-3p, miR-199a-5p, miR-126-3p, miR-127-5p, miR-144-3p, and miR-4787-5p were down-regulated in the 6-month postpartum group. In addition, 190 lipids and 269 proteins were up-regulated in the 6-month postpartum group, whereas 15 lipids and 244 proteins were down-regulated. Enrichment analysis revealed that the predicted target genes of differentially expressed miRNAs were primarily involved in cell communication and axon guidance. In parallel, the differentially expressed proteins were enriched in biosynthesis of unsaturated fatty acids and fatty acid metabolism pathway, implying a potential role in adipogenesis and neurodevelopment. CONCLUSIONS: This study reveals that the cargo contents of HBM exosomes change with the lactation period and may adapt to the needs of infant growth and development, particularly adipogenesis and neurodevelopment. HBM exosomes may play an important role in transferring genetic information from mothers to infants and be related to infants' development. The underlying mechanisms warrant further investigation and validation. FAU - Lyu, Ying AU - Lyu Y AUID- ORCID: 0009-0001-4852-794X AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Zhou, Yalin AU - Zhou Y AUID- ORCID: 0000-0002-9085-1487 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. AD - PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing 100083, China. FAU - Zhu, Xiaoyu AU - Zhu X AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Han, Muke AU - Han M AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Ye, Wanyun AU - Ye W AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Wei, Qiaosi AU - Wei Q AUID- ORCID: 0009-0000-9433-8720 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Jiang, Shilong AU - Jiang S AUID- ORCID: 0000-0001-6975-0844 AD - PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing 100083, China. AD - Feihe Research Institute, Heilongjiang Feihe Dairy Co., Ltd., Beijing 100016, China. FAU - Li, Kaifeng AU - Li K AD - PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing 100083, China. AD - Feihe Research Institute, Heilongjiang Feihe Dairy Co., Ltd., Beijing 100016, China. FAU - Xu, Yajun AU - Xu Y AUID- ORCID: 0000-0001-5791-4629 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. AD - PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing 100083, China. LA - eng GR - 2022YFD2101505/National Key Research and Development Program of China/ PT - Journal Article DEP - 20260624 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (MicroRNAs) SB - IM MH - Humans MH - *Exosomes/metabolism MH - *Milk, Human/metabolism/chemistry MH - Female MH - Multiomics MH - Infant MH - MicroRNAs/metabolism/genetics MH - *Child Development/physiology MH - Lactation/metabolism MH - Birth Cohort MH - Proteomics MH - Adult MH - Infant, Newborn PMC - PMC13362560 OTO - NOTNLM OT - adipogenesis OT - exosome OT - human breast milk OT - multi-omics OT - neurodevelopment COIS- Author Shilong Jiang and Kaifeng Li was employed by the company Feihe Research Institute Heilongjiang Feihe Dairy Co., Ltd. They participated in project administration in the study. The role of the company was recruiting participants and providing equipments storing collected human milk. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/15 10:10 MHDA- 2026/07/15 18:42 PMCR- 2026/06/24 CRDT- 2026/07/15 01:05 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/14 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 10:10 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - nu18132058 [pii] AID - nutrients-18-02058 [pii] AID - 10.3390/nu18132058 [doi] PST - epublish SO - Nutrients. 2026 Jun 24;18(13):2058. doi: 10.3390/nu18132058. PMID- 42451050 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jun 23 TI - Extending the Validity of the Feeding Practices and Structure Questionnaire Solid Feeding Version (FPSQ-S) to Mothers and Fathers Living with Socioeconomic Disadvantage. LID - 10.3390/nu18132046 [doi] LID - 2046 AB - Background/Objective: Parental feeding practices play an important role in shaping children's dietary intake, eating behaviours, and long-term health outcomes. Although several questionnaires assess feeding practices, few have been validated among socioeconomically disadvantaged populations, despite these groups being disproportionately affected by food insecurity and diet-related health inequities. This study assessed the structural validity and internal consistency of the Feeding Practices and Structure Questionnaire-Solid Feeding version (FPSQ-S)-among socioeconomically disadvantaged mothers and fathers of young children. Methods: Two cross-sectional online surveys were conducted with 178 mothers and 94 fathers of children aged 5-35 months living in disadvantaged households. Confirmatory factor analysis was used to examine the structural validity of the FPSQ-S. Internal consistency was assessed using Cronbach's alpha and Hancock's H coefficients. Results: The original six-factor FPSQ-S structure was retained and demonstrated acceptable overall model fit in this disadvantaged sample (CFI = 0.846, TLI = 0.821, RMSEA = 0.070). Internal consistency ranged from acceptable to excellent across subscales (Cronbach's alpha = 0.63-0.93; Hancock's H = 0.64-0.93). Most items loaded satisfactorily onto their intended constructs; however, two items within the Feeding on Demand construct demonstrated weak factor loadings, and this construct showed lower reliability than the remaining subscales Conclusions: This is the first study to evaluate the FPSQ-S among socioeconomically disadvantaged mothers and fathers of children aged 5-35 months. The FPSQ-S demonstrated acceptable structural validity and reliability. While the six-factor structure was largely supported, further refinement of the Feeding on Demand construct and additional psychometric evaluation are warranted. FAU - Nambiar, Smita AU - Nambiar S AUID- ORCID: 0000-0002-0626-1119 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD 4059, Australia. AD - Centre for Childhood Nutrition Research, Faculty of Health, Queensland University of Technology, 62 Graham Street, South Brisbane, QLD 4101, Australia. FAU - So, Jeffrey T H AU - So JTH AUID- ORCID: 0000-0003-0516-9609 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD 4059, Australia. AD - Centre for Childhood Nutrition Research, Faculty of Health, Queensland University of Technology, 62 Graham Street, South Brisbane, QLD 4101, Australia. AD - School of Health, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia. FAU - Jansen, Elena AU - Jansen E AUID- ORCID: 0000-0002-6051-4148 AD - Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. LA - eng GR - WCCNR03/Children's Hospital Foundation/ PT - Journal Article PT - Validation Study DEP - 20260623 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - *Feeding Behavior MH - Child, Preschool MH - Cross-Sectional Studies MH - Infant MH - *Mothers MH - *Fathers MH - Surveys and Questionnaires/standards MH - Adult MH - Reproducibility of Results MH - Socioeconomic Factors MH - Factor Analysis, Statistical MH - *Vulnerable Populations MH - Psychometrics MH - Low Socioeconomic Status PMC - PMC13362640 OTO - NOTNLM OT - confirmatory factor analysis OT - fathers OT - feeding practices questionnaire OT - infants and children OT - mothers OT - responsive feeding OT - socioeconomically disadvantage COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:37 MHDA- 2026/07/15 12:36 PMCR- 2026/06/23 CRDT- 2026/07/15 01:05 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/15 12:36 [medline] PHST- 2026/07/15 06:37 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - nu18132046 [pii] AID - nutrients-18-02046 [pii] AID - 10.3390/nu18132046 [doi] PST - epublish SO - Nutrients. 2026 Jun 23;18(13):2046. doi: 10.3390/nu18132046. PMID- 42450847 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 13 DP - 2026 Jun 24 TI - Oral Hygiene Behaviors and Their Association with Angle Malocclusion Classes in Children Aged 6-9 Years: A WHO Questionnaire-Based Study. LID - 10.3390/healthcare14131837 [doi] LID - 1837 AB - BACKGROUND: Childhood oral hygiene behaviors are crucial to preventing oral diseases and can influence the development and progression of malocclusions. The World Health Organization (WHO) Oral Health Questionnaire is a standardized tool for assessing oral hygiene behaviors, oral health-related behaviors, and preventive dental awareness in children. AIM: This study aimed to assess oral hygiene behaviours and examine associations between WHO Oral Health Questionnaire variables and Angle malocclusion classes among children aged 6-9 years. MATERIALS AND METHODS: This cross-sectional study included 90 children aged 6-9 years from the Pristina region, Kosovo. Data were collected using the WHO Oral Health Questionnaire for Children, which assessed oral hygiene habits, toothbrushing frequency, fluoride awareness, dental attendance, dietary behaviors, oral symptoms, and oral-health-related quality of life. Malocclusion was classified according to Angle classification into Class I, II, and III malocclusions with 3D intraoral scanners, Aerolscan 3. Descriptive statistical analysis, Chi-square (chi(2)) test, Spearman correlation analysis, and reliability analysis using Cronbach's Alpha were performed using SPSS Statistics 23.0 (IBM Corp., Armonk, NY, USA) and Statistica 7.1 (StatSoft Inc., Tusla, OK, USA). RESULTS: Most participants reported regular oral hygiene practices, with 46.7% brushing their teeth two or more times daily. However, limited awareness regarding fluoride-containing toothpaste was observed, as most children answered "don't know" regarding fluoride use. Occasional toothache or oral discomfort was reported by 33.3% of participants, while 23.3% reported dissatisfaction with dental appearance. Difficulty biting hard foods was present in 34.4% of children. Reliability analysis of the Q10 section demonstrated moderate internal consistency (Cronbach's Alpha = 0.500). Chi-square analysis demonstrated no statistically significant association between Angle malocclusion classes and WHO questionnaire variables (p > 0.05). The highest chi(2) value was observed for tooth-cleaning frequency (Q7) (chi(2) = 11.97; p = 0.152), although the association remained statistically non-significant. Psychosocial impact questions and oral health-related quality of life questions also demonstrated no statistically significant association with malocclusion classes. CONCLUSIONS: oral hygiene practices, preventative oral health practices, and oral health-related experiences were comparatively similar among children in different Angle malocclusion classes. Although there were no statistically significant correlations found between malocclusion classes and WHO questionnaire variables, the results show that some children have psychosocial concerns about their dental appearance and insufficient awareness of preventive oral health. The WHO Oral Health Questionnaire is a useful epidemiological tool for evaluating pediatric oral health behaviors and may help build youth orthodontic and preventive oral health policies. FAU - Veseli, Kaltrina AU - Veseli K AD - Department of Orthodontics, Alma Mater Europaea, Campus College Rezonanca, 10000 Prishtina, Kosovo. FAU - Haliti, Fehim AU - Haliti F AUID- ORCID: 0009-0004-8977-7402 AD - Department of Pediatric and Preventive Dentistry, Dental School, Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo. FAU - Veseli, Enis AU - Veseli E AD - Department of Prosthodontics, Dental School, Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13361678 OTO - NOTNLM OT - Angle classification OT - WHO Oral Health Questionnaire OT - children OT - malocclusion OT - oral hygiene OT - oral-health-related quality of life OT - pediatric oral health OT - preventive dentistry COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:34 MHDA- 2026/07/15 06:35 PMCR- 2026/06/24 CRDT- 2026/07/15 01:04 PHST- 2026/05/15 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/07/15 06:35 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 01:04 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - healthcare14131837 [pii] AID - healthcare-14-01837 [pii] AID - 10.3390/healthcare14131837 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jun 24;14(13):1837. doi: 10.3390/healthcare14131837. PMID- 42450823 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 13 DP - 2026 Jun 23 TI - Physical Activity, Physical Fitness, and Motor Competence in Children Aged 5-10 Years-A Systematic Review. LID - 10.3390/healthcare14131813 [doi] LID - 1813 AB - BACKGROUND: Motor competence (MC), physical activity (PA), and physical fitness (PF) are interrelated components of child development, yet evidence on the MC-PF-PA triad in middle childhood remains inconsistent due to methodological heterogeneity. OBJECTIVE: To synthesise associations between MC, PF, and PA in children aged 5-10 years (2020-2025) and to appraise methodological quality and certainty. METHODS: A PRISMA 2020-compliant systematic review (PROSPERO: CRD42024617560) searched six databases (PubMed, Scopus, Web of Science, SportDiscus, SciELO, PsycINFO) from January 2020 to April 2025, updated November 2025. Eligible observational studies in English reported quantitative associations between >/=2 constructs in 5-10-year-olds using validated instruments. Risk of bias was appraised in duplicate with JBI checklists. Quantitative pooling was unfeasible under a pre-specified pooling matrix; associations were synthesised narratively and certainty rated using a GRADE-style framework. RESULTS: Thirteen studies (n = 43-1064; 11 cross-sectional, 2 longitudinal) were included; six were low, five moderate, and two high risk of bias. MC-PA was predominantly positive, especially with objective instruments; MC-PF was consistently positive; PF-PA was less consistent but trended positive longitudinally. Mediation/moderation analyses (k = 3) supported roles for perceived competence, self-efficacy, and PF. Null/negative findings clustered among subjective PA measures and higher risk of bias. GRADE certainty was low-to-moderate. CONCLUSIONS: MC, PF, and PA are interconnected in middle childhood, but cross-sectional predominance and instrument heterogeneity preclude causal inference; findings are provisional and should drive longitudinal, methodologically standardised research. FAU - Rosa, Paulino Gomes AU - Rosa PG AUID- ORCID: 0000-0002-8103-4522 AD - ESECS, Polytechnique University of Leiria, 2411-901 Leiria, Portugal. AD - SPRINT-Sport Physical Activity and Health Research & Innovation Center, 6000-084 Castelo Branco, Portugal. AD - Portugal Life Quality Research Centre (CIEQV), 2040-413 Rio Maior, Portugal. FAU - Furtado, Guilherme Eustaquio AU - Furtado GE AUID- ORCID: 0000-0001-8327-1567 AD - SPRINT-Sport Physical Activity and Health Research & INnovation Center, Polytechnic University of Coimbra, Rua Dom Joao III-Solum, 3030-329 Coimbra, Portugal. AD - Applied Research Institute, Polytechnic Institute of Coimbra, Rua da Misericordia, Lagar dos Corticos-S. Martinho do Bispo, 3045-093 Coimbra, Portugal. FAU - Jacinto, Miguel AU - Jacinto M AUID- ORCID: 0000-0002-1727-3537 AD - ESECS, Polytechnique University of Leiria, 2411-901 Leiria, Portugal. AD - Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD), 6201-001 Covilha, Portugal. FAU - Ibanez, Sergio Jose AU - Ibanez SJ AUID- ORCID: 0000-0001-6009-4086 AD - Facultad de Ciencias del Deporte, Grupo de Optimizacion del Entrenamiento y Rendimiento Deportivo, Universidad de Extremadura, 10003 Caceres, Spain. FAU - Serrano, Joao AU - Serrano J AUID- ORCID: 0000-0001-5112-4984 AD - SPRINT-Sport Physical Activity and Health Research & Innovation Center, 6000-084 Castelo Branco, Portugal. AD - Department of Sports and Well-Being, Politecnic University of Castelo Branco, 6000-266 Castelo Branco, Portugal. LA - eng PT - Journal Article PT - Review DEP - 20260623 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13361801 OTO - NOTNLM OT - child health promotion OT - fundamental movement skills OT - motor skill development OT - movement behaviours OT - physical literacy OT - school-based interventions COIS- The authors declare that they have no competing interests. EDAT- 2026/07/15 10:10 MHDA- 2026/07/15 10:11 PMCR- 2026/06/23 CRDT- 2026/07/15 01:04 PHST- 2026/02/26 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/07/15 10:11 [medline] PHST- 2026/07/15 10:10 [pubmed] PHST- 2026/07/15 01:04 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - healthcare14131813 [pii] AID - healthcare-14-01813 [pii] AID - 10.3390/healthcare14131813 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jun 23;14(13):1813. doi: 10.3390/healthcare14131813. PMID- 42450725 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2076-2615 (Print) IS - 2076-2615 (Electronic) IS - 2076-2615 (Linking) VI - 16 IP - 13 DP - 2026 Jul 2 TI - Birth Type Lastingly Programs Secondary Hair Follicle Population and Cashmere Production in Cashmere Goats Despite Full Somatic Catch-Up Growth. LID - 10.3390/ani16132018 [doi] LID - 2018 AB - The objective of this study was to investigate the effects of birth type on growth performance, cashmere production traits, and hair follicle populations in cashmere goats. A total of 74 newborn kids (single, n = 38; twin, n = 36), all sired by a single Inner Mongolian Cashmere buck, were used in this study. Body weights were recorded at birth, weaning, and yearling age to calculate pre- and post-weaning average daily gain (ADG). At yearling age, cashmere samples and skin biopsies were collected for measurement of cashmere yield, fiber diameter, staple length, and primary and secondary hair follicle population parameters. Results showed that single-born kids exhibited significantly greater birth weight by 18.3% (2.85 +/- 0.06 kg vs. 2.41 +/- 0.06 kg), weaning weight by 10.3% (20.17 +/- 0.32 kg vs. 18.28 +/- 0.17 kg), pre-weaning weight gain by 9.2% (17.31 +/- 0.31 kg vs. 15.85 +/- 0.20 kg), and pre-weaning ADG by 14.5% (146.5 +/- 3.4 g vs. 127.9 +/- 1.6 g) than twin-born kids (p < 0.05). Conversely, twin-born kids surpassed single-born kids in post-weaning weight gain by 14.4% (14.60 +/- 0.48 kg vs. 12.76 +/- 0.48 kg) and post-weaning ADG by 16.8% (60.5 +/- 1.9 g vs. 51.8 +/- 1.9 g), indicative of clear compensatory growth, resulting in no significant difference in yearling weight (32.90 +/- 0.51 kg). Birth type significantly affected yearling cashmere production: single-born kids produced 10.1% more greasy cashmere (810 +/- 22 g vs. 736 +/- 28 g; p = 0.046) and exhibited a 0.45 mum finer mean fiber diameter (14.34 +/- 0.10 mum vs. 14.79 +/- 0.11 mum; p = 0.003), whereas staple length did not differ between groups (9.70 +/- 0.12 cm). Consistent with the fiber trait results, no differences were detected in any primary hair follicle population parameters. By contrast, all secondary hair follicle traits were significantly higher in single-born goats, with secondary follicle density (SFD) being 10.6% greater (36.6 +/- 1.0 vs. 33.1 +/- 0.8; p = 0.010), secondary follicle density index 11.7% greater (363.9 +/- 9.4 vs. 325.7 +/- 7.6; p = 0.003), secondary follicle number 12.4% greater (33.46 +/- 0.87 vs. 29.78 +/- 0.70; p = 0.002), and the S/P ratio 8.9% greater (12.11 +/- 0.36 vs. 11.12 +/- 0.29; p = 0.041). All secondary follicle population parameters were negatively correlated with fiber diameter, among which SFD showed the strongest association (r = -0.70, p < 0.001). These findings indicate that birth type is associated with lasting differences in secondary hair follicle endowment and cashmere production, which persist at least through yearling age despite full compensatory body growth in twin-born kids. The observed association is consistent with the hypothesis that the pre-weaning period constitutes a critical window for follicle maturation-a window during which secondary follicle development is highly sensitive to nutritional status during gestation and early postnatal life. This suggests that targeted nutritional management of twin-bearing does during late gestation and early lactation may represent a promising strategy to partially mitigate the disadvantage in cashmere production potential imposed by twinning. However, direct causal evidence for both the developmental programming hypothesis and the efficacy of such nutritional interventions requires further experimental validation, including longer-term studies tracking animals across multiple production cycles and controlled nutritional trials. FAU - Li, Kunjiang AU - Li K AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. FAU - Wang, Shaojie AU - Wang S AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. FAU - Wang, Zhenguo AU - Wang Z AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. FAU - Jing, Xiujuan AU - Jing X AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. FAU - Zeng, Zheqiao AU - Zeng Z AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. FAU - Shen, Yanfang AU - Shen Y AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. FAU - Jiang, Guojing AU - Jiang G AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. FAU - Liu, Shuqi AU - Liu S AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. FAU - Zhang, Chunxiang AU - Zhang C AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. FAU - Yang, Chunhe AU - Yang C AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. AD - Key Laboratory of Farm Animal Genetic Resources Exploration and Breeding of Shanxi Province, Taigu 030801, China. FAU - Ren, Youshe AU - Ren Y AD - College of Animal Science, Shanxi Agricultural University, Taigu 030801, China. AD - Key Laboratory of Farm Animal Genetic Resources Exploration and Breeding of Shanxi Province, Taigu 030801, China. LA - eng PT - Journal Article DEP - 20260702 PL - Switzerland TA - Animals (Basel) JT - Animals : an open access journal from MDPI JID - 101635614 PMC - PMC13359727 OTO - NOTNLM OT - cashmere goat OT - cashmere yield OT - compensatory growth OT - fiber diameter OT - follicle density OT - litter size OT - secondary hair follicle COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:34 MHDA- 2026/07/15 06:35 PMCR- 2026/07/02 CRDT- 2026/07/15 01:04 PHST- 2026/05/25 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/15 06:35 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 01:04 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - ani16132018 [pii] AID - animals-16-02018 [pii] AID - 10.3390/ani16132018 [doi] PST - epublish SO - Animals (Basel). 2026 Jul 2;16(13):2018. doi: 10.3390/ani16132018. PMID- 42449312 OWN - NLM STAT- MEDLINE DCOM- 20261010 LR - 20261011 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 14 TI - Diagnostic performance of insulin resistance indices and their association with metabolic outcomes in children with obesity: a 10-year retrospective study from a tertiary pediatric endocrinology center. LID - 10.1186/s12887-026-07183-w [doi] LID - 969 AB - BACKGROUND: Childhood obesity is strongly associated with insulin resistance (IR) and related metabolic complications. However, the optimal surrogate marker for identifying IR in pediatric populations remains unclear. OBJECTIVE: To evaluate the diagnostic performance of commonly used IR indices and to investigate their association with metabolic outcomes in children and adolescents with obesity. METHODS: This retrospective study included 899 children and adolescents with obesity followed at a tertiary pediatric endocrinology center over a 10-year period. IR was defined based on oral glucose tolerance test (OGTT) findings. The diagnostic performance of the fasting glucose-to-insulin ratio (FGIR), quantitative insulin sensitivity check index (QUICKI) and the homeostatic model assessment for insulin resistance (HOMA-IR) was assessed using receiver operating characteristic (ROC) curve analysis. Associations between IR, metabolic syndrome (MS), dysglycemia, hepatic steatosis, and biochemical parameters were analyzed. Multivariate logistic regression was performed to identify independent predictors. RESULTS: HOMA-IR demonstrated the highest diagnostic performance for identifying IR (AUC: 0.711 in girls and 0.700 in boys), outperforming FGIR and QUICKI. Among pubertal participants, the optimal HOMA-IR cut-off values for predicting OGTT-defined insulin resistance were 4.22 in girls and 4.18 in boys. IR was present in 76.3% of participants and was associated with an unfavorable metabolic profile, including higher rates of dysglycemia and hepatic steatosis. Hepatic steatosis was detected in 63.5% of children and was significantly more common in boys. In multivariate analysis, male sex, BMI-SDS, and ALT were independent predictors of hepatic steatosis, whereas IR parameters were not independently associated. TSH levels were higher in IR and MS groups but remained within the normal range. CONCLUSION: HOMA-IR is a reliable and practical marker for identifying IR in children with obesity. While IR is associated with multiple metabolic disturbances, adiposity and liver-related markers appear to play a more dominant role in predicting hepatic steatosis. A comprehensive metabolic evaluation, including both fasting indices and dynamic tests, is essential for early risk stratification in pediatric obesity. CI - (c) 2026. The Author(s). FAU - Eroglu Filibeli, Berna AU - Eroglu Filibeli B AD - Department of Pediatric Endocrinology, Izmir City Hospital, Izmir, Turkey. FAU - Vural Topaktas, Gulumay AU - Vural Topaktas G AD - Department of Pediatric Endocrinology, Izmir City Hospital, Izmir, Turkey. FAU - Yildirim, Julide Gulizar AU - Yildirim JG AD - Faculty of Health Sciences Public Health Nursing Department, Izmir Katip Celebi University, Izmir, Turkey. FAU - Dundar, Bumin AU - Dundar B AD - Department of Pediatric Endocrinology, Izmir Katip Celebi University, Izmir, Turkey. nuri.dundar@ikc.edu.tr. LA - eng PT - Journal Article DEP - 20260714 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Blood Glucose) RN - 0 (Biomarkers) RN - 0 (Insulin) SB - IM MH - Humans MH - *Insulin Resistance MH - Retrospective Studies MH - Female MH - Male MH - Child MH - Glucose Tolerance Test MH - *Pediatric Obesity/complications/metabolism/blood MH - Adolescent MH - ROC Curve MH - Metabolic Syndrome/diagnosis/etiology MH - Blood Glucose/metabolism/analysis MH - Biomarkers/blood MH - Tertiary Care Centers MH - Insulin/blood MH - Fatty Liver/etiology/diagnosis MH - Logistic Models PMC - PMC13651063 OTO - NOTNLM OT - HOMA-IR OT - Hepatic steatosis OT - Insulin resistance OT - Metabolic syndrome OT - Pediatric obesity COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Tepecik Training and Research Hospital (Approval number: 2022/03 - 02). Written informed consent was obtained from the parents or legal guardians of all participants under 16 years of age in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 06:38 MHDA- 2026/10/10 10:05 PMCR- 2026/07/14 CRDT- 2026/07/15 00:08 PHST- 2026/04/16 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/10/10 10:05 [medline] PHST- 2026/07/15 06:38 [pubmed] PHST- 2026/07/15 00:08 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1186/s12887-026-07183-w [pii] AID - 7183 [pii] AID - 10.1186/s12887-026-07183-w [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 14;26(1):969. doi: 10.1186/s12887-026-07183-w. PMID- 42449271 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jul 14 TI - Nomogram model for predicting spontaneous preterm birth in twin pregnancies: a case-control study. LID - 10.1186/s12884-026-09663-4 [doi] LID - 1130 AB - BACKGROUND: This study aimed to identify independent factors and develop a nomogram for spontaneous preterm birth in twin pregnancies. METHODS: In this retrospective study, a total of 218 women with twin pregnancies from Jiaxing Women and Children's Hospital, Wenzhou Medical University between June 2021 and May 2024 were enrolled. Univariate analysis and subsequent multivariate logistic regression analysis were used to identify independent factors. A nomogram prediction model was constructed using R software and evaluated by the area under the ROC curve (AUC), concordance index (C-index), and decision curve analysis (DCA). RESULTS: Univariate analysis identified body mass index (BMI) at delivery, cervical length during the second trimester, cervical funnel, gestational vaginitis, gestational diabetes mellitus and prenatal hemoglobin levels as factors associated with spontaneous preterm birth in twin pregnancies (P < 0.05). Multivariable logistic regression analysis confirmed BMI at delivery (OR = 0.887), cervical length during the second trimester (OR = 0.886), and gestational vaginitis (OR = 2.909) as independent predictors. The prediction model demonstrated good performance, with a C-index of 0.838 for the nomogram and an AUC of 0.838 from the ROC curve. DCA indicated the model provided net clinical benefit across a wide range of threshold probabilities. CONCLUSION: A nomogram incorporating BMI at delivery, cervical length during the second trimester, and gestation vaginitis status effectively predicts spontaneous preterm birth in twin pregnancies. This practical tool may aid in individualized risk assessment and guide clinical management. CI - (c) 2026. The Author(s). FAU - Xu, Wei-Na AU - Xu WN AD - Department of Obstetrical, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. FAU - Ai, Ling AU - Ai L AD - Department of Obstetrical, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. FAU - Zhang, Xiao-Yan AU - Zhang XY AD - Department of Central Laboratory, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. FAU - Wang, Jian-Guo AU - Wang JG AD - Department of Central Laboratory, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. FAU - Huang, Yi-Min AU - Huang YM AD - Department of Central Laboratory, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. 15957317870@163.com. LA - eng GR - 2023AY31023/Science and Technology Bureau of Jiaxing City/ GR - 2024KY1694/Zhejiang Provincial Medical and health Science and Technology Program/ PT - Journal Article DEP - 20260714 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Nomograms MH - *Premature Birth/diagnosis/epidemiology/etiology MH - *Pregnancy, Twin MH - Retrospective Studies MH - Adult MH - Case-Control Studies MH - Risk Factors MH - Body Mass Index MH - ROC Curve MH - Cervical Length Measurement MH - Pregnancy Trimester, Second MH - Logistic Models MH - Diabetes, Gestational PMC - PMC13647848 OTO - NOTNLM OT - Delivery outcome OT - Nomogram OT - Risk factor OT - Spontaneous preterm birth OT - Twin pregnancies COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Jiaxing Women and Children's Hospital, Wenzhou Medical University (2024-Y-43). Written informed consent was obtained from all women enrolled in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 06:34 MHDA- 2026/10/08 05:31 PMCR- 2026/07/14 CRDT- 2026/07/15 00:07 PHST- 2024/09/03 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 00:07 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1186/s12884-026-09663-4 [pii] AID - 9663 [pii] AID - 10.1186/s12884-026-09663-4 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jul 14;26(1):1130. doi: 10.1186/s12884-026-09663-4. PMID- 42449095 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jul 14 TI - A cross-sectional study of the associations between intuitive eating and maladaptive eating behaviors in Brazilian University students. LID - 10.1007/s40519-026-01888-8 [doi] LID - 85 AB - PURPOSE: To investigate the relationships between Intuitive Eating and maladaptive eating behaviors among Brazilian university students. METHODS: A cross-sectional quantitative study was conducted among technical, undergraduate, and postgraduate students aged 18 years or above, between 2020 and 2021. Participants completed an online survey comprising sociodemographic questions, the Intuitive Eating Scale-2 (IES-2), and the Three-Factor Eating Questionnaire-Revised 21 (TFEQ-R21), both validated for the Brazilian population. Spearman's correlation and MANCOVA tests were used to assess associations between study variables. RESULTS: The study included 1,237 participants (82.6% females) with a mean age of 26.3 (SD = 8.0) years. Intuitive Eating and its domains were negatively associated with Cognitive Restraint, Emotional Eating and Uncontrolled Eating. In the MANCOVA model, the Unconditional Permission to Eat subscale (IES-2) explained a large proportion of variance in Cognitive Restraint (eta2p = .314), and the Eating for Physical Rather than Emotional Reasons subscale (IES-2) explained a large proportion of variance in Emotional Eating (eta2p = .587). CONCLUSION: Intuitive eating and its domains were negatively associated with maladaptive eating behaviors among Brazilian university students, particularly Emotional Eating and Cognitive Restraint, with Eating for Physical Rather than Emotional Reasons and Unconditional Permission to Eat showing the strongest relationships. LEVEL OF EVIDENCE: Level 4-Cross-sectional study. CI - (c) 2026. The Author(s). FAU - Yavorivski, Andressa AU - Yavorivski A AD - School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Ruiz, Ana Correa AU - Ruiz AC AD - School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Poinhos, Rui AU - Poinhos R AUID- ORCID: 0000-0002-9177-6423 AD - Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal. ruipoinhos@fcna.up.pt. AD - Department of Biology and Environment, School of Life and Environmental Sciences, University of Tras-os-Montes e Alto Douro, Vila Real, Portugal. ruipoinhos@fcna.up.pt. FAU - Feoli, Ana Maria Pandolfo AU - Feoli AMP AD - Postgraduate Program in Psychology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. LA - eng PT - Journal Article DEP - 20260714 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Brazil MH - Adult MH - Male MH - *Feeding Behavior/psychology MH - Young Adult MH - *Students/psychology MH - Universities MH - Emotional Eating MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/psychology MH - Adolescent MH - Emotions/physiology MH - *Eating/psychology MH - *Intuition/physiology PMC - PMC13645931 OTO - NOTNLM OT - Disordered eating OT - Eating behavior OT - Emotional eating OT - Intuitive eating OT - Uncontrolled eating COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 00:35 MHDA- 2026/10/08 05:31 PMCR- 2026/07/14 CRDT- 2026/07/14 23:35 PHST- 2024/09/11 00:00 [received] PHST- 2026/07/05 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/15 00:35 [pubmed] PHST- 2026/07/14 23:35 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1007/s40519-026-01888-8 [pii] AID - 1888 [pii] AID - 10.1007/s40519-026-01888-8 [doi] PST - epublish SO - Eat Weight Disord. 2026 Jul 14;31(1):85. doi: 10.1007/s40519-026-01888-8. PMID- 42449006 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2509-8020 (Electronic) IS - 2509-8020 (Linking) VI - 10 IP - 1 DP - 2026 Jul 14 TI - Linguistical and psychometric validation of the MIND Youth Questionnaire (My-Q) in Swedish. LID - 10.1186/s41687-026-01148-4 [doi] LID - 121 AB - BACKGROUND: The Mind Youth Questionnaire is a multidimensional health-related quality-of-life questionnaire designed for pediatric diabetes care and exists in Dutch, English, and Spanish. METHODS: The aim of this study was to linguistically and psychometrically validate the Mind Youth Questionnaire (My-Q) for Swedish-speaking youths with type 1 diabetes. The linguistic process of the Dutch version followed ISPOR s guidelines. For face validity, youths with type 1 diabetes and diabetes nurses were interviewed. Three stigma items were included. The final Swedish My-Q consists of 38 items. A total of 166 youths (10-19 years) completed the My-Q and Pediatric Quality of Life Inventory diabetes module. A 2nd -order confirmatory factor analysis was conducted using the nine-factor Dutch and five-factor Spanish versions. RESULTS: The 2nd -order nine-factor solution (social impact, parents, diabetes control perceptions, responsibilities, worries, treatment satisfaction, body image and eating behavior, stigma, and mood) showed adequate fit: chi2(551) = 828.36 (p < .01), Comparative Fit Index (CFI) = 0.90, Root Mean Square Error of Approximation (RMSEA) = 0.05 [0.05,0.06], Standardized Root Mean Square Residual (SRMR) = 0.08. The nine-factor solution and grouping of the items followed a clear rationale. The reliability coefficients of the total scale were adequate, alpha = 0.86, Omega = 0.90, and Omega for all the factors ranged from 0.49 to 0.88. The relationships between My-Q factors and sociodemographic variables revealed that boys had better health-related quality of life than girls. Younger youths reported better health-related quality of life in terms of body image and eating behavior (p=.005). Concurrent validity was confirmed, as all the factors were positively related to all the Pediatric Quality of Life Inventory diabetes module factors. A negative correlation was found between the level of glycated hemoglobin and the My-Q score (r=-.258, p < .001). CONCLUSION: The Swedish My-Q has adequate psychometric properties and can be used in research and for routine psychosocial assessment. CI - (c) 2026. The Author(s). FAU - Brorsson, Anna Lena AU - Brorsson AL AUID- ORCID: 0000-0002-8136-6340 AD - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. anna-lena.brorsson@ki.se. AD - Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. anna-lena.brorsson@ki.se. FAU - Rudilla, David AU - Rudilla D AUID- ORCID: 0000-0002-6042-4724 AD - Pulmonology, Air Liquide Healthcare, Hospital Universitario de la Princesa, Madrid, Spain. FAU - Kleijberg, Max AU - Kleijberg M AD - Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. AD - Department of Health Sciences, Innovation and Design, Malardalen University, Eskilstuna, Sweden. FAU - deWit, Maartje AU - deWit M AD - Medical Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. FAU - Lundberg, Elena AU - Lundberg E AD - Department of Pediatrics, Institution of Clinical Science, Umea University, Umea, Sweden. FAU - Lindholm-Olinder, Anna AU - Lindholm-Olinder A AUID- ORCID: 0000-0002-8422-2457 AD - Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden. AD - Sachs Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20260714 PL - Germany TA - J Patient Rep Outcomes JT - Journal of patient-reported outcomes JID - 101722688 SB - IM MH - Humans MH - Male MH - Female MH - *Diabetes Mellitus, Type 1/psychology/therapy MH - Adolescent MH - Psychometrics MH - Child MH - *Quality of Life/psychology MH - Sweden MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Young Adult MH - Linguistics MH - Body Image MH - Factor Analysis, Statistical PMC - PMC13373108 OTO - NOTNLM OT - Questionnaire OT - Type 1 diabetes OT - Validation OT - Youth COIS- Declarations. Ethics approval and consent to participate: The Swedish Ethical Review Authority approved this study (no: 2022-03838-01 and 2022-05738-02), which was conducted in accordance with the Declaration of Helsinki [34]. Consent for publication: Before inclusion, participants and their parents received oral and written information. The participants signed informed consent forms. In accordance with Swedish regulations, the legal guardians of participants under 15 years of age also signed an informed consent form. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 00:35 MHDA- 2026/07/15 12:37 PMCR- 2026/07/14 CRDT- 2026/07/14 23:32 PHST- 2026/02/04 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/15 12:37 [medline] PHST- 2026/07/15 00:35 [pubmed] PHST- 2026/07/14 23:32 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1186/s41687-026-01148-4 [pii] AID - 1148 [pii] AID - 10.1186/s41687-026-01148-4 [doi] PST - epublish SO - J Patient Rep Outcomes. 2026 Jul 14;10(1):121. doi: 10.1186/s41687-026-01148-4. PMID- 42448733 OWN - NLM STAT- Publisher LR - 20260714 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 14 TI - Development of a consistent body mass index. LID - 10.1038/s41598-026-61284-1 [doi] AB - A new body mass index, termed Consistent Body Mass Index CBMI=[Formula: see text], is developed from first principles. Customarily used Body Mass Index (BMI[Formula: see text]) or its variant Tri-ponderal Mass Index (TMI[Formula: see text]) or other measures serving to the purpose of classifying the anthropometric status of a person have repeatedly been demonstrated to be unsatisfactory in various aspects. A new index inclusive of all ages, body sizes, and sexes is therefore needed. A non-dimensional hence scalable index CBMI, which correlates well with waist-to-height ratio, [Formula: see text], is developed from fundamental relations. Correlation levels of CBMI and TMI against waist-to-height ratio [Formula: see text] are compared for measurements comprising participants ranging from 1-day-old to 75-year-old male and female infants, children, and adults. Waist-to-height ratio [Formula: see text], which correlates well, [Formula: see text], with CBMI is a reliable measure of the anthropometric status of a person. New criteria and relevant charts, based on [Formula: see text] and CBMI, are established for classifying anthropometric status levels. CBMI can also be used as an estimator for ideal body weight for a definite CBMI value and a given height [Formula: see text] from [Formula: see text]. CI - (c) 2026. The Author(s). FAU - Beji, Serdar AU - Beji S AUID- ORCID: 0000-0002-1927-9262 AD - Department of Computer Engineering, Faculty of Engineering and Natural Sciences, Biruni University, 34015, Zeytinburnu, Istanbul, Turkey. sbeji@biruni.edu.tr. FAU - Kizilkaya Beji, Nezihe AU - Kizilkaya Beji N AUID- ORCID: 0000-0002-6254-4412 AD - Department of Nursing, Faculty of Health Sciences, Biruni University, Zeytinburnu, Istanbul, 34015, Turkey. FAU - Mutlu, Ummu AU - Mutlu U AUID- ORCID: 0000-0002-5259-7326 AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260714 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Ideal body weight estimation OT - New classifications of body anthropometric status levels OT - Non-dimensional new body mass index OT - Obesity OT - Public health OT - Waist-to-height ratio COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Verbal informed consent was obtained from all participants. Verbal consent was witnessed and formally recorded. EDAT- 2026/07/15 00:33 MHDA- 2026/07/15 00:33 CRDT- 2026/07/14 23:21 PHST- 2026/04/15 00:00 [received] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/07/15 00:33 [medline] PHST- 2026/07/15 00:33 [pubmed] PHST- 2026/07/14 23:21 [entrez] AID - 10.1038/s41598-026-61284-1 [pii] AID - 10.1038/s41598-026-61284-1 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 14. doi: 10.1038/s41598-026-61284-1. PMID- 42447709 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260828 IS - 1532-2688 (Electronic) IS - 1059-1311 (Linking) VI - 141 DP - 2026 Sep TI - Predicting the efficacy of classic ketogenic diet therapy in children with refractory epilepsy using dynamic changes in the glucose-ketone index (GKI). PG - 80-85 LID - S1059-1311(26)00189-5 [pii] LID - 10.1016/j.seizure.2026.06.017 [doi] AB - OBJECTIVE: To investigate the predictive value of dynamic changes in blood glucose, blood ketones and glucose-ketone index (GKI) for the efficacy of the classic ketogenic diet (CKD)in children with refractory epilepsy. METHODS: Data from 189 children with refractory epilepsy who received classic ketogenic diet(CKD) between January 2018 and December 2024 were retrospectively analyzed. Blood glucose, blood ketones and the glucose-ketone index (GKI) which defined as the ratio of blood glucose to blood ketone were monitored at multiple time points, from the 2-day period of halving carbohydrate intake to 90 days after CKD initiation. Patients were divided into a responder group (>/=50% seizure reduction) and a non-responder group based on Engel's classification after three months of treatment. Group differences in metabolic indices were assessed, and receiver operating characteristic(ROC) analysis identified optimal GKI thresholds for predicting response. RESULTS: On the first day of CKD therapy, GKI (AUC = 0.638) was the best single predictor of efficacy among all time points, with a cut-off value of 9.63 (sensitivity and specificity both 0.63). Combining blood glucose (<4.95 mmol/L) and blood ketone (>0.75 mmol/L) levels improved predictive performance (AUC = 0.661). CONCLUSION: A GKI > 9.63 on the first day of CKD therapy may serve as an early-warning indicator of poor treatment response. The early treatment phase-from the second day of halving carbohydrate intake to the first day of CKD-represents a critical window for metabolic transition. Monitoring dynamic changes in GKI and blood ketone may facilitate timely adjustment of intervention strategies. CI - Copyright (c) 2026 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. FAU - Li, Jiang AU - Li J AD - Department of Neonatology, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, China. FAU - Wang, Tianqi AU - Wang T AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Yu, Lifei AU - Yu L AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. Electronic address: yulf_ek@fudan.edu.cn. FAU - Ni, Yan AU - Ni Y AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Li, Yijie AU - Li Y AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Zhang, Yunjian AU - Zhang Y AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Zhou, Shuizhen AU - Zhou S AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Wang, Yi AU - Wang Y AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260629 PL - England TA - Seizure JT - Seizure JID - 9306979 RN - 0 (Ketones) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - *Drug Resistant Epilepsy/diet therapy/blood MH - *Ketones/blood MH - Female MH - *Blood Glucose/metabolism MH - Male MH - Retrospective Studies MH - Child MH - Treatment Outcome MH - Child, Preschool MH - Adolescent OTO - NOTNLM OT - Blood ketone OT - CKD OT - Children with refractory epilepsy OT - Classic ketogenic diet OT - Efficacy prediction OT - GKI COIS- Declaration of competing interest All authors declare no competing interests. EDAT- 2026/07/15 00:34 MHDA- 2026/08/28 23:34 CRDT- 2026/07/14 18:06 PHST- 2026/06/14 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/08/28 23:34 [medline] PHST- 2026/07/15 00:34 [pubmed] PHST- 2026/07/14 18:06 [entrez] AID - S1059-1311(26)00189-5 [pii] AID - 10.1016/j.seizure.2026.06.017 [doi] PST - ppublish SO - Seizure. 2026 Sep;141:80-85. doi: 10.1016/j.seizure.2026.06.017. Epub 2026 Jun 29. PMID- 30000831 STAT- Publisher CTDT- 20260715 PB - National Institute of Child Health and Human Development DP - 2006 TI - Lecithin. BTI - Drugs and Lactation Database (LactMed(R)) AB - Lecithin is a mixture of choline, choline esters, fatty acids, glycerol, glycolipids, triglycerides, phosphoric acid, and phospholipids, such as phosphatidylcholine that are normal components of human milk. Supplemental lecithin has been recommended as a treatment for plugged milk ducts,[1-3] and as an additive to human milk that is given to preterm infants via pumping through plastic tubing in order to prevent fat loss.[4] No scientifically valid clinical studies exist on the safety and efficacy of high-dose lecithin supplementation in nursing mothers or infants. Most nursing mothers do not have adequate choline intake and mothers of preterm infants may have reduced levels of choline in milk and greater frequency of depression.[5-7] A meta-analysis found that higher maternal choline intake was likely to be associated with better child neurocognition and neurodevelopment.[8] The choline concentration in milk showed positive association with fine motor and adaptability developmental quotient in breastfed infants at 6 months of age.[9] Supplementation with one component of lecithin, phosphatidylcholine, increases choline, but not phosphatidylcholine concentrations in breastmilk and supplementation with choline increases choline metabolites, but not choline in breastmilk. Lecithin is usually well tolerated and is considered to be "generally recognized as safe" (GRAS) by the U.S. Food and Drug Administration. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site. LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Phospholutein OT - Granulestin OT - Ovovitellin OT - Lecithine OT - Lecithins OT - Lecithol OT - Vitellin OT - Gliddex OT - Kelecin OT - Alcolec S OT - Phosphatidylcholine OT - Choline OT - Acti-flow 68-sb OT - Emulthin M-35 OT - LECITHIN OT - CCRIS 7265 OT - HSDB 1903 OT - LT-02 OT - EINECS 232-307-2 EDAT- 2026/07/15 00:00 CRDT- 2026/07/15 00:00 AID - NBK501772 [bookaccession] PMID- 42447464 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Jul 14 TI - Physical Activity Guidance Resources for Rural Families of Neurodiverse or Developmentally Diverse Children: Exploratory Co-Design Study. PG - e92658 LID - 10.2196/92658 [doi] LID - e92658 AB - BACKGROUND: Being active benefits children and their parents, but there is a lack of co-designed resources that support families to engage in physical activity (PA) together. OBJECTIVE: This exploratory co-design study aimed to identify ways to optimize guidance resources intended to assist in being active together, and to evaluate the co-design approach it used. METHODS: Physiotherapist-researchers with experience and expertise in family PA drafted 2 evidence-informed prototypes. One prototype informed families about the holistic benefits of being active together, while the other helped families to plan their episode of PA. Twelve parents from 9 rural families and their neurodiverse or developmentally diverse children (n=13) were recruited as co-designers to ensure a wide range of considerations. Family co-designers took part in 2 to 3 workshops. They trialed the prototypes, telling researchers what worked well and how to improve them. Child and adult advisory groups oversaw the co-design approach. Each group met 3 times, with the child advisory group meeting prior to the adult advisory group. A child voice facilitator and advocate was used to support the child advisory groups and facilitate communication between child and adult advisory groups. RESULTS: Sixty-two changes were made to the prototypes in response to feedback from families and researcher observations. Key changes to resources recommended by children, parents, and researchers to increase user acceptability and usability included changing the ordering of the planning resource to reflect the way that most families used it, adding a "hard words" section to improve readability, support to normalize that no-one wins all the time, additional examples to cover each section of the resources, and encourage negotiation among families to ensure that the planned PA was mutually desirable. All families used the resources to successfully complete, or adapt, their planned session of PA together. Overall, co-designers and advisory group members perceived the co-design approach to be appropriate and responsive. However, the researchers identified a possible gap in final communication with the children regarding dissemination of results of the project which were provided to families via parents' email. CONCLUSIONS: The co-design approach used in this study supported families, including neurodiverse and developmentally diverse children, to trial and provide feedback on PA resources. The large number of changes made to the resources from co-designer suggestions and researcher observations highlights the importance of gaining user feedback for consumer resources. Future research is needed to evaluate how these co-designed resources may impact family PA behavior and identity. The transparent co-design approach and evaluation highlighted limitations for research communication to children, which require careful consideration in future similar studies. CI - (c) Kate Freire, Rodney Pope, Kristen Andrews, Jason Bennie, Megan Suthern. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Freire, Kate AU - Freire K AUID- ORCID: 0000-0001-5932-741X AD - Three Rivers Department of Rural Health, Charles Sturt University, Elizabeth Mitchell Drive, Thurgoona, New South Wales, 2640, Australia, 61 260519361, 61 1800 275278. FAU - Pope, Rodney AU - Pope R AUID- ORCID: 0000-0002-1320-5801 AD - School of Allied Health, Exercise and Sports Sciences, Charles Sturt University, Thurgoona, New South Wales, Australia. FAU - Andrews, Kristen AU - Andrews K AUID- ORCID: 0000-0002-9891-7401 AD - School of Allied Health, Exercise and Sports Sciences, Charles Sturt University, Thurgoona, New South Wales, Australia. FAU - Bennie, Jason AU - Bennie J AUID- ORCID: 0000-0002-8668-8998 AD - Murrumbidgee Primary Health Network, Wagga Wagga, NSW, Australia. FAU - Suthern, Megan AU - Suthern M AUID- ORCID: 0000-0001-7360-8680 AD - Paediatric Department, Wagga Wagga Base Hospital, Wagga Wagga, New South Wales, Australia. LA - eng PT - Journal Article DEP - 20260714 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13367945 OTO - NOTNLM OT - co-design OT - family OT - neurodiversity OT - parenting OT - physical activity COIS- Conflicts of Interest: None declared. EDAT- 2026/07/14 18:38 MHDA- 2026/07/14 18:39 PMCR- 2026/07/14 CRDT- 2026/07/14 16:33 PHST- 2026/02/05 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/14 18:39 [medline] PHST- 2026/07/14 18:38 [pubmed] PHST- 2026/07/14 16:33 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - v9i1e92658 [pii] AID - 92658 [pii] AID - 10.2196/92658 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Jul 14;9:e92658. doi: 10.2196/92658. PMID- 42447299 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1944-0057 (Electronic) IS - 1944-0057 (Linking) VI - 43 IP - 8 DP - 2026 Aug TI - A multi-tiered approach for human health risk assessment of pesticide residues in green peppers using Monte Carlo simulation. PG - 1182-1195 LID - 10.1080/19440049.2026.2691366 [doi] AB - Exposure to pesticide residues in vegetables remains a major concern for human health. This study proposes a robust, multi-tiered human health risk assessment framework to support food safety decision-making, using sweet green peppers as a case study. The approach integrates regulatory compliance assessment (Tier 1), deterministic evaluation (Tier 2), and probabilistic modelling (Tier 3). Pesticide residues from 80 samples were quantified using a QuEChERS UPLC-MS/MS method validated according to SANTE/11312/2021 guidelines. Residues were detected in 37.5% of samples, with 13 active substances quantified above the limit of quantification, and only 3.75% exceeding EU maximum residue limits, indicating high compliance. The deterministic assessment (Tier 2), based on a conservative intake-to-body weight ratio and mean concentrations of quantified residues, resulted in cumulative hazard index (HI) values of 0.044 for adults and 0.046 for children/adolescents. The inclusion of non-quantified compounds using the Middle-Bound approach (LOQ/2) increased the cumulative HI values to 0.067 for adults and 0.071 for children/adolescents. In contrast, the probabilistic risk assessment (Tier 3), based on fitted distributions of residue concentrations and dietary intake, yielded cumulative risk estimates at upper exposure percentiles (p90-p99), ranging from 0.0006 to 0.0045 for adults and from 0.0011 to 0.0057 for children/adolescents. These findings highlight the added value of probabilistic approaches for characterising dietary risk by incorporating exposure variability and reducing uncertainty. In particular, Tier 3 enables a more realistic estimation of exposure based on limited quantitative data and allows the integration and interpretation of values below the LOQ, thereby contributing to a more robust risk assessment. FAU - Boudriiya, Imane AU - Boudriiya I AD - Biotechnology and Biomolecular Engineering Research Team, Faculty of Sciences and Technologies of Tangier, University of Abdelmalek Essaadi, Tangier, Morocco. AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Marti, Vicenc AU - Marti V AD - Chemical Engineering Department, Escola d'Enginyeria de Barcelona Est (EEBE), Universitat Politecnica de Catalunya (UPC)-BarcelonaTECH and Barcelona Research Center for Multiscale Science and Engineering (CCEM), Barcelona, Spain. FAU - Kounnoun, Ayoub AU - Kounnoun A AD - Faculty, of Medical Sciences, UM6P Hospitals, Mohammed VI Polytechnic University, Benguerir, Morocco. FAU - El Maadoudi, Mohammed AU - El Maadoudi M AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Alahlah, Naoual AU - Alahlah N AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Ait Lamine, Naima AU - Ait Lamine N AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Laglaoui, Amin AU - Laglaoui A AD - Biotechnology and Biomolecular Engineering Research Team, Faculty of Sciences and Technologies of Tangier, University of Abdelmalek Essaadi, Tangier, Morocco. FAU - Hassani Zerrouk, Mounir AU - Hassani Zerrouk M AD - Biotechnology and Biomolecular Engineering Research Team, Faculty of Sciences and Technologies of Tangier, University of Abdelmalek Essaadi, Tangier, Morocco. LA - eng PT - Journal Article DEP - 20260714 PL - England TA - Food Addit Contam Part A Chem Anal Control Expo Risk Assess JT - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment JID - 101485040 RN - 0 (Pesticide Residues) SB - IM MH - Risk Assessment MH - Humans MH - *Pesticide Residues/analysis MH - *Capsicum/chemistry MH - *Food Contamination/analysis MH - *Monte Carlo Method MH - Tandem Mass Spectrometry OTO - NOTNLM OT - QuEChERS OT - UPLC-MS/MS OT - dietary exposure OT - hazard index OT - hazard quotient OT - probabilistic exposure modelling EDAT- 2026/07/14 18:43 MHDA- 2026/08/07 12:39 CRDT- 2026/07/14 15:12 PHST- 2026/08/07 12:39 [medline] PHST- 2026/07/14 18:43 [pubmed] PHST- 2026/07/14 15:12 [entrez] AID - 10.1080/19440049.2026.2691366 [doi] PST - ppublish SO - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2026 Aug;43(8):1182-1195. doi: 10.1080/19440049.2026.2691366. Epub 2026 Jul 14. PMID- 42447132 OWN - NLM STAT- Publisher LR - 20260714 IS - 1097-0010 (Electronic) IS - 0022-5142 (Linking) DP - 2026 Jul 14 TI - Ultra-processed foods and their implications for agriculture, health, and policy reform. LID - 10.1002/jsfa.70899 [doi] AB - Ultra-processed foods (UPFs) present an increasing challenge for food system governance and the well-being of human communities. The aim of this study is to analyze the systemic role of UPFs within food systems and to identify legal and policy interventions addressing their health, agricultural, and environmental impacts. This article explores the intersection of UPF-dominated food environments with health disparities, agricultural incentives, and environmental pressures, drawing on insights from international policy developments and legal analysis. It reviews recent global and European initiatives, including the World Health Organization's 2025 guidance and the European Union's actions to limit the availability and marketing of UPFs. The article advocates regulatory approaches that extend beyond single-nutrient frameworks to address food processing as an inherent aspect of contemporary food systems. The analysis identifies pathways connecting UPFs to human outcomes, including elevated obesity rates among adults, increased exposure of children to targeted UPF marketing, and the commodity-driven production of cereals, sugars, and oilseeds used in both UPFs and animal feeds. Additionally, it underscores environmental externalities, such as energy-intensive processing, packaging waste, and the pressures on land and water resources concentrated in rural areas. Ultimately, the article proposes legally feasible measures that integrate public health and sustainability objectives. These include public procurement standards, fiscal and marketing controls on UPFs, enhanced labeling practices, and support for short supply chains, thereby linking food law reform to goals of equity and sustainability. (c) 2026 Society of Chemical Industry. CI - (c) 2026 Society of Chemical Industry. FAU - Chaba, Dawid AU - Chaba D AUID- ORCID: 0000-0002-2385-3466 AD - Department of Administrative Law and Civil Society, Institute of Law, Economics and Administration, University of the National Education Commission, Krakow, Poland. FAU - Labudda, Mateusz AU - Labudda M AUID- ORCID: 0000-0001-8014-1644 AD - Department of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences - SGGW, Warsaw, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260714 PL - England TA - J Sci Food Agric JT - Journal of the science of food and agriculture JID - 0376334 SB - IM OTO - NOTNLM OT - agricultural systems OT - environmental impacts OT - food law OT - short supply chains OT - sustainability OT - ultra-processed foods EDAT- 2026/07/14 18:41 MHDA- 2026/07/14 18:41 CRDT- 2026/07/14 13:34 PHST- 2026/04/28 00:00 [revised] PHST- 2026/03/20 00:00 [received] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/07/14 18:41 [medline] PHST- 2026/07/14 18:41 [pubmed] PHST- 2026/07/14 13:34 [entrez] AID - 10.1002/jsfa.70899 [doi] PST - aheadofprint SO - J Sci Food Agric. 2026 Jul 14. doi: 10.1002/jsfa.70899. PMID- 42446605 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260926 IS - 1559-0720 (Electronic) IS - 0163-4984 (Linking) VI - 204 IP - 10 DP - 2026 Oct TI - Correlation Between Salivary and Urinary Iodine Indicators in Lactating Women: A Cross-Sectional Study. PG - 8001-8009 LID - 10.1007/s12011-026-05239-7 [doi] AB - Iodine is essential for infant growth and neurodevelopment. To assess iodine nutritional status in populations or individuals a 24-hour urinary iodine concentration (24 h-UIC) is a reliable biomarker but relatively time-consuming and inconvenient method, therefore, more simple alternatives are required. This study examined the correlation between salivary iodine concentration (SIC) and commonly used iodine-related indicators, that is, 24 h-UIC and breast milk iodine concentration (BMIC), and explored the potential of SIC as a biomarker in lactating women. This study recruited 29 healthy lactating women in Luoyang City, Henan Province, China. Over five consecutive days, 24-hour urine samples were collected daily, while saliva and breast milk samples were collected once a day. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine iodine concentrations in urine, saliva and breast milk. Statistical analyses included Spearman correlation analysis to assess associations between SIC and urinary iodine-related measurements. The median 24 h-UIC was 114.8 microg/L, indicating adequate iodine nutrition in this study population (median UIC < 100 microg/L). SIC showed significant positive correlations with 24 h-UIC and 24-hour urinary iodine excretion (24 h-UIE) (r = 0.689 and 0.460, respectively; P < 0.001), whereas no significant correlation was observed between SIC and BMIC (r = 0.047, P > 0.05). When participants were grouped according to 24 h-UIC (< 100 microg/L vs. >/=100 microg/L), higher SIC levels were observed in the group with higher 24 h-UIC (SIC: 163.4 vs. 109.2 microg/L). The intraindividual variability of SIC was lower than inter-individual variability (18.5 vs. 35.2%), suggesting relatively stable within-subject measurements over repeated sampling. The positive correlation between SIC and 24 h-UIC or 24 h-UIE suggests that SIC may serve as a convenient non-invasive indicator associated with urinary iodine-related measurements in lactating women. However, the observed relationships are exploratory, and further validation in larger and more diverse populations is needed. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Pan, Ziyun AU - Pan Z AD - Key Laboratory of Environmental Nutrition and Population Health, School of Public Health, Department of Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China. FAU - Li, Xiaorui AU - Li X AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Zhao, Teng AU - Zhao T AD - Cangzhou Maternal and Child Health Care Hospital, Cangzhou, Hebei, China. FAU - Wang, Xiru AU - Wang X AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Zhang, Ying AU - Zhang Y AD - Key Laboratory of Environmental Nutrition and Population Health, School of Public Health, Department of Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China. FAU - Wang, Jingyi AU - Wang J AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Xie, Haozhuo AU - Xie H AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Cai, Yuyang AU - Cai Y AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Li, Changjiang AU - Li C AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Zhang, Wenhui AU - Zhang W AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Zeng, Ziyan AU - Zeng Z AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Duan, Lijun AU - Duan L AD - Tianjin First Center Hospital, Tianjin, China. duanlijun79@163.com. FAU - Sang, Zhongna AU - Sang Z AUID- ORCID: 0000-0002-0234-7214 AD - Key Laboratory of Environmental Nutrition and Population Health, School of Public Health, Department of Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China. sangzhongna@tmu.edu.cn. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - Biol Trace Elem Res JT - Biological trace element research JID - 7911509 RN - 9679TC07X4 (Iodine) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Iodine/urine/analysis MH - *Lactation/urine/metabolism MH - Adult MH - *Milk, Human/chemistry MH - Cross-Sectional Studies MH - *Saliva/chemistry/metabolism MH - Biomarkers/urine MH - Young Adult OTO - NOTNLM OT - Iodine OT - Lactating women OT - Salivary iodine concentration OT - Urinary iodine concentration COIS- Declarations. Ethics Approval: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Tianjin Medical University(approval number: TMUhMEC2022003). Consent for Publication: Not applicable. Consent to Participate: Written informed consent was obtained from all participants prior to enrollment in the study. Competing Interests: The authors declare no competing interests. EDAT- 2026/07/14 12:35 MHDA- 2026/09/27 02:25 CRDT- 2026/07/14 11:06 PHST- 2026/03/02 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/09/27 02:25 [medline] PHST- 2026/07/14 12:35 [pubmed] PHST- 2026/07/14 11:06 [entrez] AID - 10.1007/s12011-026-05239-7 [pii] AID - 10.1007/s12011-026-05239-7 [doi] PST - ppublish SO - Biol Trace Elem Res. 2026 Oct;204(10):8001-8009. doi: 10.1007/s12011-026-05239-7. Epub 2026 Jul 14. PMID- 42446071 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1099-0968 (Electronic) IS - 1072-4133 (Print) IS - 1072-4133 (Linking) VI - 34 IP - 6 DP - 2026 Nov TI - Weight Bias Internalisation and Health-Related Quality of Life in Adolescents: What Role Do Family Meals Play? PG - 1648-1659 LID - 10.1002/erv.70142 [doi] AB - OBJECTIVE: Weight bias internalisation (WBI) has been associated with poorer health-related quality of life (HRQoL), however, evidence in community-based adolescent samples remains scarce. Family meals have shown protective effects on adolescent health, yet their role in the relationship between WBI and HRQoL has not yet been explored. This study investigated associations between WBI, HRQoL, and family meals in Spanish adolescents. METHOD: We conducted a cross-sectional study with a representative sample of 1016 adolescents aged 11-16 from Terrassa, Spain (random multistage cluster sampling). Validated instruments were used to assess WBI (WBIS-M), HRQoL (KIDSCREEN-27), and family dinner quality and frequency. Anthropometric data were objectively measured. Adjusted regression models were conducted. RESULTS: Lower WBI and a higher frequency and quality of family dinners were associated with higher HRQoL scores across KIDSCREEN-27 domains. Further analyses revealed that family dinners moderated the effect of WBI on two HRQoL factors, attenuating its negative impact. However, this moderating impact became substantially weaker at higher levels of WBI. CONCLUSIONS: This study of Spanish adolescents is the first to show a negative association between WBI and HRQoL and that this relationship is moderated by the frequency and quality of shared family meals, suggesting that supportive family environments can buffer WBI's negative impact, although this protective role is attenuated at the highest levels of WBI, highlighting the vital need for early prevention, and warranting further investigation. CI - (c) 2026 Beat Eating Disorders and John Wiley & Sons Ltd. All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies. FAU - Broto-Puig, Jaume AU - Broto-Puig J AD - Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Latorre-Millan, Miriam AU - Latorre-Millan M AD - Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. AD - Miguel Servet University Hospital, Institute for Health Research Aragon (IIS Aragon), Zaragoza, Spain. AD - Department of Pharmacy and Nutrition, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odon, Madrid, Spain. FAU - Penelo, Eva AU - Penelo E AD - Departament de Psicobiologia i de Metodologia de les Ciencies de la Salut, Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Bach-Faig, Anna AU - Bach-Faig A AD - NUTRALiSS Research Group, Faculty of Health Sciences, Open University of Catalonia (UOC), Barcelona, Spain. FAU - Sanchez-Carracedo, David AU - Sanchez-Carracedo D AD - Department of Clinical and Health Psychology, Universitat Autonoma de Barcelona, Barcelona, Spain. LA - eng GR - RTI2018-099293-B-I00/Spanish Ministry of Science and Innovation/ GR - PID2022-138977OB-I00/Spanish Ministry of Science and Innovation/ PT - Journal Article DEP - 20260714 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - Adolescent MH - *Quality of Life/psychology MH - Female MH - Cross-Sectional Studies MH - Child MH - Spain MH - Male MH - *Meals/psychology MH - *Body Weight MH - *Family/psychology MH - *Feeding Behavior/psychology MH - *Body Image/psychology PMC - PMC13656762 OTO - NOTNLM OT - family dinner index OT - family meals OT - quality of life OT - weight bias internalisation OT - weight stigma COIS- The authors declare no conflicts of interest. EDAT- 2026/07/14 14:00 MHDA- 2026/10/12 11:41 PMCR- 2026/10/12 CRDT- 2026/07/14 08:03 PHST- 2026/06/09 00:00 [revised] PHST- 2026/03/09 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/07/14 14:00 [pubmed] PHST- 2026/07/14 08:03 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - ERV70142 [pii] AID - 10.1002/erv.70142 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Nov;34(6):1648-1659. doi: 10.1002/erv.70142. Epub 2026 Jul 14. PMID- 42445937 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260714 LR - 20260813 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 12 IP - 3 DP - 2026 TI - Associations of academic performance, sports participation, disordered eating and menstrual cycle irregularities in adolescents: a population-based study. PG - e003078 LID - 10.1136/bmjsem-2025-003078 [doi] LID - e003078 AB - BACKGROUND: Regular menstruation is an important indicator of well-being in adolescent females. We aimed to assess risk factors associated with menstrual cycle irregularities in a population-based cohort of high school students. METHODS: In the fall of 2022, we recruited a cohort of 1161 first-year female students from 21 socio-economically diverse high schools in the capital region of Finland. Participants completed an online survey addressing menstruation, academic performance and sports participation and validated questionnaires (the Sick-Control-One stone-Fat-Food (SCOFF) eating disorder screening tool and School Burnout Inventory). RESULTS: Of 935 (81%) participants (mean age 16) not using hormonal preparations, 336 (37%) reported irregular menstruation. Elevated School Burnout Inventory scores (per point OR 1.03, 95% CI 1.01 to 1.05), lower body mass index (OR 1.86, 95% CI 1.12 to 3.08) and high SCOFF scores (OR 2.09, 95% CI 1.40 to 3.10) were associated with irregular menstruation. Overall physical activity levels showed no significant association with menstruation. In subgroup analysis, low body mass index and disordered eating symptoms were associated with irregular menstruation among casual exercisers whereas school burnout was associated with irregular menstruation among competitive athletes. CONCLUSION: School-related stress, eating and exercise habits should be evaluated among high school students presenting with menstrual irregularities, as these factors may be relevant in identifying adolescents at risk of more severe reproductive dysfunctions, including amenorrhoea. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Moro, Sara Maria Margareeta AU - Moro SMM AUID- ORCID: 0009-0007-7340-5817 AD - Helsinki University Hospital, New Children's Hospital, Helsinki, Finland. AD - Clinicum, University of Helsinki, Helsinki, Finland. FAU - Holopainen, Elina AU - Holopainen E AD - Clinicum, University of Helsinki, Helsinki, Finland. AD - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. FAU - Saari, Viivi AU - Saari V AD - Clinicum, University of Helsinki, Helsinki, Finland. AD - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. FAU - Kosola, Silja AU - Kosola S AD - Clinicum, University of Helsinki, Helsinki, Finland. AD - Research Services, Western Uusimaa County Wellbeing Services, Espoo, Finland. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC13358262 OTO - NOTNLM OT - Adolescent OT - Eating disorders OT - Menstruation OT - Physical activity COIS- None declared. EDAT- 2026/07/14 18:26 MHDA- 2026/07/14 18:27 PMCR- 2026/07/10 CRDT- 2026/07/14 06:56 PHST- 2025/11/05 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/14 18:27 [medline] PHST- 2026/07/14 18:26 [pubmed] PHST- 2026/07/14 06:56 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - bmjsem-2025-003078 [pii] AID - 10.1136/bmjsem-2025-003078 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2026 Jul 10;12(3):e003078. doi: 10.1136/bmjsem-2025-003078. eCollection 2026. PMID- 42445753 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1658-3175 (Electronic) IS - 0379-5284 (Print) IS - 0379-5284 (Linking) VI - 47 IP - 8 DP - 2026 Aug TI - Dietary Fat Intake and Its Influence on the Association Between Liver Fat and Brain Choline Metabolism in Young Saudi Women. PG - 1309-1315 LID - 10.15537/1658-3175.8822 [doi] AB - OBJECTIVE: Fat-rich nutrition may influence the neurochemical consequences of hepatic lipid accumulation. This study examined whether percent energy from fat modifies the association between liver fat and the brain (Cho/Cr) ratio in healthy young women. METHODS: A total of 109 healthy Saudi women aged 18-25 years underwent brain magnetic resonance spectroscopy ((1)H-MRS) to quantify Cho/Cr ratios. Liver fat was estimated using MRI-based proton density fat fraction (PDFF), and lipid intake was assessed using a validated food frequency questionnaire. Multivariable regression models tested the interaction between liver fat and fat-derived energy intake, followed by simple slopes analysis, regression diagnostics, and false discovery rate (FDR) correction. RESULTS: A modest but statistically significant interaction was observed between liver fat and reported fat intake in relation to the brain Cho/Cr ratio (p = 0.037). The association between liver fat and Cho/Cr appeared stronger at higher levels of fat consumption (+1 SD) and weaker at lower intake (-1 SD). Regression diagnostics indicated no multicollinearity or heteroscedasticity, and FDR correction supported the stability of the interaction. CONCLUSION: Fat intake may modify the relationship between liver fat and brain choline metabolism in young women. These findings suggest that nutritional context could play a role in liver-brain metabolic coupling, although the effect size is modest and should be interpreted with caution. CI - Copyright: (c) Saudi Medical Journal. FAU - Hawesa, Halima S AU - Hawesa HS AUID- ORCID: 0000-0002-8478-971X AD - Department of Radiological Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Box 84428, Riyadh 11671, Saudi Arabia. FAU - Shanawani, Mansour E AU - Shanawani ME AD - Department of Radiology, King Abdullah bin Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia. FAU - Alshegri, Haya A AU - Alshegri HA AD - Department of Radiology, King Abdullah bin Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia. FAU - Hassan, Mahasin G AU - Hassan MG AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. FAU - Alorainy, Amal I AU - Alorainy AI AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. FAU - Alroqaiba, Nouf A AU - Alroqaiba NA AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. FAU - Sheikh, Shanoo G A AU - Sheikh SGA AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. LA - eng PT - Journal Article DEP - 20260707 PL - Saudi Arabia TA - Saudi Med J JT - Saudi medical journal JID - 7909441 RN - N91BDP6H0X (Choline) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Female MH - *Choline/metabolism MH - *Brain/metabolism MH - *Liver/metabolism MH - Young Adult MH - Adult MH - Saudi Arabia MH - Adolescent MH - *Dietary Fats/administration & dosage MH - Magnetic Resonance Spectroscopy PMC - PMC13360573 OTO - NOTNLM OT - Brain/metabolism OT - Choline/metabolism OT - Dietary fats OT - Fatty liver OT - Female OT - Magnetic resonance spectroscopy OT - Saudi Arabia OT - Young adult EDAT- 2026/07/14 18:26 MHDA- 2026/07/14 18:27 PMCR- 2026/08/01 CRDT- 2026/07/14 06:54 PHST- 2025/11/24 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/07/14 18:27 [medline] PHST- 2026/07/14 18:26 [pubmed] PHST- 2026/07/14 06:54 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - saudimedj-47-8-1309 [pii] AID - 10.15537/1658-3175.8822 [doi] PST - ppublish SO - Saudi Med J. 2026 Aug;47(8):1309-1315. doi: 10.15537/1658-3175.8822. Epub 2026 Jul 7. PMID- 42444614 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1099-1492 (Electronic) IS - 0952-3480 (Print) IS - 0952-3480 (Linking) VI - 39 IP - 8 DP - 2026 Aug TI - Serum and Urine Metabolomic Profiles in Children With Growth Retardation: An Exploratory (1)H-NMR Study. PG - e70356 LID - 10.1002/nbm.70356 [doi] LID - e70356 AB - Growth retardation, defined by impaired anthropometric development relative to age-based population standards, may be accompanied by metabolic alterations. This study aimed to characterize serum and urine metabolomic profiles in children with growth retardation using exploratory (1)H-NMR spectroscopy. Thirty children with growth retardation and 24 controls were included in this cross-sectional study. Serum and urine samples were analyzed by (1)H-NMR spectroscopy, and annotated metabolites were evaluated using Chenomx, MetaboAnalyst, and R software. Clinical and laboratory variables were compared between groups. Metabolomic analysis included univariate comparisons, volcano plots, PCA, OPLS-DA, Spearman correlation analysis, age-adjusted regression, exploratory ROC analysis, and metabolite set enrichment analysis. The growth retardation group had lower age and BMI than controls, while serum iron and AST were higher. Volcano plot analysis showed a more distinct pattern of nominal metabolite alterations in serum than in urine. In serum, 3-hydroxybutyrate and glucuronate showed relative increases, whereas N-acetylgalactosamine, alanine, glutamate, and glucose showed relative decreases. In urine, metabolite differences were less pronounced. Multivariate analysis demonstrated a significant overall group effect in serum but not in urine. Within the growth retardation group, age was negatively correlated with serum 3-hydroxybutyrate and positively correlated with N-acetyl-L-aspartic acid, whereas several urinary metabolites showed negative correlations with age. After age adjustment, only 4-ethylbenzoic acid remained significant in serum after multiple testing correction. Exploratory ROC analysis identified N-acetylgalactosamine and 4-ethylbenzoic acid in serum and beta-alanine and creatinine in urine as the metabolites with the highest within cohort classification tendency. Children with growth retardation exhibited modest metabolic differences, with more consistent group-related alterations observed in serum than in urine. These findings mainly suggest changes related to energy metabolism, amino acid turnover, and intermediary metabolism. However, the results remain exploratory and require confirmation in larger, age-stratified and independently validated cohorts. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Alim, Mehtap AU - Alim M AUID- ORCID: 0000-0003-0818-7714 AD - Health Sciences Institute, Bezmialem Vakif University, Istanbul, Turkiye. AD - Department of Medical Biochemistry, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkiye. FAU - Demirel, Metin AU - Demirel M AUID- ORCID: 0000-0003-4810-6771 AD - Department of Medical Biochemistry, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkiye. FAU - Koktasoglu, Fatmanur AU - Koktasoglu F AUID- ORCID: 0000-0002-3201-5923 AD - Department of Medical Biochemistry, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkiye. FAU - Ozgurhan, Gamze AU - Ozgurhan G AUID- ORCID: 0000-0002-8063-1931 AD - Clinic of Pediatrics, Istanbul Education Research Hospital, Istanbul, Turkiye. FAU - Pasin, Ozge AU - Pasin O AUID- ORCID: 0000-0001-6530-0942 AD - Department of Biostatistics, Hamidiye Medical Faculty, Health Sciences University, Istanbul, Turkiye. FAU - Bas, Suleyman AU - Bas S AUID- ORCID: 0000-0002-5883-445X AD - University of Health Sciences, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkiye. FAU - Selek, Sahabettin AU - Selek S AUID- ORCID: 0000-0003-1235-3957 AD - Department of Medical Biochemistry, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkiye. LA - eng GR - 20240602/Bezmialem Vakif Universitesi/ PT - Journal Article PL - England TA - NMR Biomed JT - NMR in biomedicine JID - 8915233 SB - IM MH - Humans MH - Male MH - Female MH - *Metabolomics MH - *Metabolome MH - Child MH - *Proton Magnetic Resonance Spectroscopy MH - *Growth Disorders/urine/blood/metabolism MH - Child, Preschool MH - Multivariate Analysis PMC - PMC13366460 OTO - NOTNLM OT - acetylgalactosamine OT - magnetic resonance spectroscopy OT - metabolic networks and pathways OT - metabolic profiling OT - pediatric growth disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/07/14 14:02 MHDA- 2026/07/14 14:03 PMCR- 2026/07/14 CRDT- 2026/07/14 06:23 PHST- 2026/06/18 00:00 [revised] PHST- 2026/04/04 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/14 14:03 [medline] PHST- 2026/07/14 14:02 [pubmed] PHST- 2026/07/14 06:23 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - NBM70356 [pii] AID - 10.1002/nbm.70356 [doi] PST - ppublish SO - NMR Biomed. 2026 Aug;39(8):e70356. doi: 10.1002/nbm.70356. PMID- 42443631 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260821 IS - 1550-9397 (Electronic) IS - 1550-9389 (Print) IS - 1550-9389 (Linking) VI - 22 IP - 1 DP - 2026 Jul 13 TI - Leveraging convenient wearable technology to assess adolescent sleep: physical and behavioral health correlates of single-channel sleep electroencephalogram in a community sample of youth. LID - 10.1007/s44470-026-00118-3 [doi] LID - 113 AB - STUDY OBJECTIVES: Sleep disturbances during adolescence heighten risk for physical and behavioral health problems, yet sleep physiological markers critical to health outcomes are rarely assessed in pediatric care. Wearable single-channel electroencephalography (EEG) devices may offer scalable, ecologically valid methods for assessing sleep physiology in home settings. This study evaluated whether single-channel sleep-EEG metrics were associated with physical and behavioral health in adolescents. METHODS: Eighty-five community-derived adolescents (ages 11-17, 50% female) completed seven consecutive nights of at-home, single-channel sleep-EEG, physical health assessments (i.e., body mass index and blood pressure), and subjective sleep and behavioral health measures. Parents provided psychiatric diagnosis history. RESULTS: Odds of being overweight/obese decreased with greater REM duration (- 2.72% per minute) and higher REM percentage (- 100% per 1%). Odds of hypertension decreased with greater time spent in stage 3 (N3) (- 4.78% per minute). Multivariate analyses showed reduced N3 sleep was associated with parent-reported ADHD symptoms, whereas shorter total sleep time, lower sleep efficiency (SE), and longer sleep onset latency (SOL) were associated with higher adolescent-reported ADHD and conduct problems (p's < .05). Odds of an ADHD diagnosis increased with longer SOL (+ 1.92% per minute) and slower N3 decline (+ 89.4% per 0.01 units) but decreased with higher SE (- 7.78% per 1%). Odds of an internalizing disorder increased with higher SE (+ 12.4% per 1%) and greater wake after sleep onset (+ 3.18% per minute), but decreased with more REM sleep (- 9.62% per minute). CONCLUSIONS: Findings highlight the clinical value of wearable sleep-EEG for detecting sleep-related risk processes during adolescence. By capturing physiological features not accessible through self-report, at-home sleep-EEG may flag youth who could benefit from sleep-focused interventions, complementing routine care in identifying risk of future health problems. Integrating such tools into pediatric settings could support more precise, developmentally informed approaches to prevention and intervention. CURRENT STUDY/STUDY RATIONALE: Sleep disturbances are common during adolescence and increase risk for physical conditions such as obesity and hypertension, as well as behavioral health problems, yet sleep physiology is rarely adequately assessed in pediatric care. Wearable single-channel EEG offers an accessible way to capture sleep architecture and continuity that subjective reports cannot provide. This study shows that EEG-derived sleep features, including REM, N3 sleep, sleep efficiency, and sleep-onset latency, are associated with physical and behavioral health outcomes above and beyond adolescent and caregiver reports. STUDY IMPACT: These findings highlight the potential value of integrating wearable EEG into routine care to identify sleep-related vulnerabilities and support targeted prevention efforts. CI - (c) 2026. American Academy of Sleep Medicine. FAU - Flannery, Jamie L AU - Flannery JL AUID- ORCID: 0000-0002-2971-6702 AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA. Jamie.flannery@duke.edu. FAU - Engelhard, Matthew M AU - Engelhard MM AD - Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA. FAU - Kansagra, Sujay AU - Kansagra S AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. FAU - Kollins, Scott H AU - Kollins SH AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA. FAU - Krystal, Andrew AU - Krystal A AD - Departments of Psychiatry and Neurology, University of California San Francisco School of Medicine, San Francisco, CA, USA. FAU - Lunsford-Avery, Jessica R AU - Lunsford-Avery JR AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA. LA - eng GR - R01 MH135875/MH/NIMH NIH HHS/United States GR - T32 MH132515/MH/NIMH NIH HHS/United States GR - 5T32-MH132515-02/National Institute of Health Sciences/ PT - Journal Article DEP - 20260713 PL - Switzerland TA - J Clin Sleep Med JT - Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine JID - 101231977 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - *Electroencephalography/instrumentation/methods MH - *Wearable Electronic Devices MH - Child MH - *Sleep Wake Disorders/diagnosis/physiopathology MH - Sleep Duration MH - Digital Health PMC - PMC13365060 MID - NIHMS2183030 OTO - NOTNLM OT - ADHD OT - Adolescent OT - Hypertension OT - Internalizing disorders OT - Obesity OT - Sleep COIS- Declarations. Ethics approval and consent to participate: All study procedures were approved by Duke University's Institutional Review Board. Consent and assent were obtained from all participants. Consent for publication: All authors reviewed and approved the manuscript. Competing interests: JLF and MME report no conflicts of interest. SK has reported an equity stake in Lullabee, Inc. and was compensated by Apple, Inc. for producing sponsored social media content highlighting the Apple Watch sleep apnea detection feature. SHK has reported being an employee and equity shareholder in Aura, Inc. ADK has received research support from Alkermes; Janssen Pharmaceuticals, Axsome Pharmaceutics, Attune, Eisai, Harmony, Neumora; Neurocrine Biosciences, The Ray and Dagmar Dolby Family Fund, Weill Institute for Neurosciences, and the National Institutes of Health and consulting fees for advisory board participation from Axsome Therapeutics, Abbvie, Big Health, Eisai, Evecxia, Harmony Biosciences, Idorsia, Janssen Pharmaceuticals, Jazz Pharmaceuticals, Neurocrine Biosciences, Neumora, Neurawell, Otsuka, Sage, Takeda; and has stock options with Neurawell and Big-Health. JRLA has received research support from Supernus and is a consultant for NIMH grant R01MH135875 to Rutgers University. EDAT- 2026/07/14 00:34 MHDA- 2026/07/14 12:34 PMCR- 2026/07/15 CRDT- 2026/07/13 23:36 PHST- 2026/03/11 00:00 [received] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/05/19 00:00 [revised] PHST- 2026/07/14 12:34 [medline] PHST- 2026/07/14 00:34 [pubmed] PHST- 2026/07/13 23:36 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1007/s44470-026-00118-3 [pii] AID - 10.1007/s44470-026-00118-3 [doi] PST - epublish SO - J Clin Sleep Med. 2026 Jul 13;22(1):113. doi: 10.1007/s44470-026-00118-3. PMID- 42443053 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 7 DP - 2026 Jul TI - Differences in Fat Depots, Cardiometabolic Risk Factors, and Insulin Resistance Between Active and Passive School Commuters. PG - e70134 LID - 10.1111/ijpo.70134 [doi] LID - e70134 AB - BACKGROUND: Active commuting to and from school (ACS) is a feasible strategy to increase daily physical activity in children. Although ACS has been associated with favourable body composition and selected cardiometabolic markers, its association with specific ectopic fat depots remains unclear in paediatric populations. OBJECTIVE: To examine differences in specific fat depots and cardiometabolic risk factors between children who actively and passively commute to school. METHODS: Cross-sectional baseline data from 174 children (48.9% girls; mean age 10.8 +/- 1.4 years) participating in the EFIGRO and MICROKID projects were analysed. ACS mode was self-reported using a validated questionnaire and classified as active or passive. Visceral adipose tissue, abdominal subcutaneous adipose tissue, intermuscular abdominal adipose tissue, hepatic fat, intrapancreatic fat, and lumbar spine marrow fat were assessed using magnetic resonance imaging. Cardiometabolic risk factors included blood pressure, triglycerides, high-density lipoprotein cholesterol, glucose, insulin, and insulin resistance estimated by the homeostasis model assessment. RESULTS: No significant differences were observed between active and passive commuters for any fat depot (all p >/= 0.150) or cardiometabolic risk factors, including insulin resistance and the overall cardiometabolic risk score (all p >/= 0.220). CONCLUSIONS: Active commuting to/from school was not associated with differences in ectopic fat depots, cardiometabolic risk factors, or insulin resistance in children. CI - (c) 2026 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Rodriguez-Sanchez, David AU - Rodriguez-Sanchez D AUID- ORCID: 0009-0006-5498-2240 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Huertas-Delgado, Francisco Javier AU - Huertas-Delgado FJ AD - "La Inmaculada" Teacher Training Centre, University of Granada, Granada, Spain. FAU - Medrano, Maria AU - Medrano M AD - Department of Health Sciences, Institute for Sustainability & Food Chain Innovation (IS-FOOD), Public University of Navarra, Pamplona, Spain. AD - IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. FAU - Idoate, Fernando AU - Idoate F AD - Radiology Department, Mutua Navarra, Department of Health Sciences, Public University of Navarra, Pamplona, Spain. FAU - Cabeza, Rafael AU - Cabeza R AD - Department of Electrical, Electronic and Communications Engineering, Public University of Navarra, Pamplona, Spain. FAU - Cadenas-Sanchez, Cristina AU - Cadenas-Sanchez C AUID- ORCID: 0000-0002-4513-9108 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. FAU - Labayen, Idoia AU - Labayen I AD - Department of Health Sciences, Institute for Sustainability & Food Chain Innovation (IS-FOOD), Public University of Navarra, Pamplona, Spain. AD - IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. LA - eng GR - DEP2016-78377-R/Spanish Ministry of Industry and Competitiveness/ GR - PI13/01335/Spanish Ministry of Health "Fondos de Investigacion Sanitaria del Instituto de Salud Carlos III"/ GR - 0011-1365-2019-000085/Department of Economic Development of the Government of Navarra/ GR - European Union Structural Funds (European Regional Development Fund, FEDER, "Una manera de hacer Europa")/ GR - FPU23/02198/Spanish Ministry of Universities/ GR - European Union's Horizon 2020/ GR - 101028929/Marie Sklodowska-Curie/ GR - NNF23SA0083955/European Association for the Study of Obesity-Novo Nordisk Foundation/ GR - CB22/03/00058/CIBEROBN/ GR - Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion, and the European Union/ GR - Universidad de Granada/CBUA/ PT - Journal Article PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - Female MH - *Insulin Resistance MH - Child MH - Cross-Sectional Studies MH - Cardiometabolic Risk Factors MH - Male MH - *Transportation MH - Schools MH - Magnetic Resonance Imaging MH - *Exercise MH - Risk Factors MH - *Cardiovascular Diseases/prevention & control MH - Body Composition MH - Adiposity MH - *Adipose Tissue PMC - PMC13364722 OTO - NOTNLM OT - active transport OT - cardiometabolic health OT - ectopic adiposity OT - metabolic syndrome COIS- The authors declare no conflicts of interest. EDAT- 2026/07/14 00:35 MHDA- 2026/07/14 12:35 PMCR- 2026/07/14 CRDT- 2026/07/13 22:02 PHST- 2026/06/19 00:00 [revised] PHST- 2026/01/22 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/14 12:35 [medline] PHST- 2026/07/14 00:35 [pubmed] PHST- 2026/07/13 22:02 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - IJPO70134 [pii] AID - 10.1111/ijpo.70134 [doi] PST - ppublish SO - Pediatr Obes. 2026 Jul;21(7):e70134. doi: 10.1111/ijpo.70134. PMID- 42442643 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260810 IS - 1872-7573 (Electronic) IS - 0378-8741 (Linking) VI - 372 DP - 2027 Jan 10 TI - Assessment of Xiao'er Xiexieting Keli-induced toxicity in juvenile rats. PG - 122185 LID - S0378-8741(26)01039-1 [pii] LID - 10.1016/j.jep.2026.122185 [doi] AB - ETHNOPHARMACOLOGICAL RELEVANCE: Sufficient safety data on juvenile development is not available for Xiao'er Xiexieting Keli (XXTK), a Chinese herbal formula for pediatric diarrhea. AIM OF THE STUDY: Considering the challenges associated with clinical trials of XXTK, this study was aimed at evaluating its toxicity in juvenile rats to obtain a basis for assessing its safety and dosage in children. MATERIALS AND METHODS: In acute toxicity study (Study 1), postnatal day (PND) 24 rats were orally administered 253.13 g/kg XXTK and observed over 14 days. In subacute toxicity study (Study 2), PND21 rats were administered 1.74, 8.71, or 32.66 g/kg XXTK daily for six consecutive weeks and allowed to recover for 4 weeks. Clinical signs, body weight, food intake, and timing of vaginal opening and preputial separation were recorded during the dosing period. Hematological, serum biochemical, and histopathological examinations, Irwin's test, and assessment of growth hormone levels, skeletal development, and immune-related indicators were performed mid-administration, and at culmination of dosing and recovery. Urinalysis, ophthalmological assessment, and Morris water maze test were conducted at the end of dosing and recovery periods. RESULTS: No deaths or significant findings occurred in Study 1; maximum tolerated dose was 253.13 g/kg. In Study 2, all changes were reversible, mild, and without toxicological significance. The no-observed-adverse-effect level was 32.66 g/kg/day. CONCLUSION: XXTK demonstrated a favorable toxicological safety profile in juvenile rats, supporting its potential for extended clinical use in children. Further evaluation of child development-related indicators and validation in pediatric clinical cohorts are recommended. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Liu, Junxiu AU - Liu J AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Zhu, Lin AU - Zhu L AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. FAU - Lu, Xiaojing AU - Lu X AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. FAU - Fu, Weidong AU - Fu W AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. FAU - Rao, Tingfei AU - Rao T AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. FAU - Zhang, Lili AU - Zhang L AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Wang, Jiahong AU - Wang J AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Chen, Lingfang AU - Chen L AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Tian, Ruiyu AU - Tian R AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Zhu, Haojie AU - Zhu H AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Ge, Lingyun AU - Ge L AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Wu, Lei AU - Wu L AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Lv, Wanqiang AU - Lv W AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Huang, Wenhai AU - Huang W AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. Electronic address: hwh@hmc.edu.cn. FAU - Huang, Linfeng AU - Huang L AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. Electronic address: hlf8165771@126.com. FAU - Song, Yisheng AU - Song Y AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. Electronic address: alicesys_song@163.com. LA - eng PT - Journal Article DEP - 20260713 PL - Ireland TA - J Ethnopharmacol JT - Journal of ethnopharmacology JID - 7903310 RN - 0 (Drugs, Chinese Herbal) SB - IM MH - Animals MH - *Drugs, Chinese Herbal/toxicity/administration & dosage MH - Female MH - Male MH - Rats MH - No-Observed-Adverse-Effect Level MH - Toxicity Tests, Acute MH - Rats, Sprague-Dawley MH - Dose-Response Relationship, Drug MH - Body Weight/drug effects OTO - NOTNLM OT - Acute toxicity OT - Juvenile OT - No-observed adverse effect level OT - Safety evaluation OT - Subacute toxicity OT - Xiao'er Xiexieting Keli COIS- Declaration of competing interest I have nothing to declare. EDAT- 2026/07/14 00:34 MHDA- 2026/08/11 00:35 CRDT- 2026/07/13 19:13 PHST- 2026/05/26 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/12 00:00 [accepted] PHST- 2026/08/11 00:35 [medline] PHST- 2026/07/14 00:34 [pubmed] PHST- 2026/07/13 19:13 [entrez] AID - S0378-8741(26)01039-1 [pii] AID - 10.1016/j.jep.2026.122185 [doi] PST - ppublish SO - J Ethnopharmacol. 2027 Jan 10;372:122185. doi: 10.1016/j.jep.2026.122185. Epub 2026 Jul 13. PMID- 42442595 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 1096-0295 (Electronic) IS - 0273-2300 (Linking) VI - 171 DP - 2026 Nov TI - Bisphenol A concentrations in isot spice and associated health risk assessment using Monte Carlo simulation in Turkiye. PG - 106179 LID - S0273-2300(26)00152-2 [pii] LID - 10.1016/j.yrtph.2026.106179 [doi] AB - Bisphenol A (BPA) is a well-known endocrine-disrupting chemical, yet its potential migration into traditional spice matrices during processing remains a critical and overlooked food safety concern. To address this knowledge gap, this study presents the first comprehensive investigation of BPA concentrations in isot spice and assesses the associated dietary health risks. A total of 46 samples (23 homemade and 23 industrial) from Sanliurfa, Turkey, were analyzed using a validated ELISA kit, along with pH and CIELAB color parameters. Estimated Daily Intake (EDI) and Target Hazard Quotient (THQ) were calculated for adult and pediatric populations using Monte Carlo simulations. BPA concentrations ranged from 0.40 to 361.30 mug/kg (mean: 73.88 +/- 19.15 mug/kg) in homemade samples and from 0.49 to 285.39 mug/kg (mean: 67.15 +/- 14.87 mug/kg) in industrial samples, with no significant differences between groups (p > 0.05). While dietary risks were within safe limits according to US EPA doses, assessment based on stricter European Food Safety Authority (EFSA) thresholds revealed that THQ values significantly exceeded 1, particularly for children, indicating potential chronic health risks. These findings highlight the prevalence of BPA in traditional spices and underscore the need for improved production and packaging practices to reduce consumer exposure. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Oncu, Cemile AU - Oncu C AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. FAU - Aydemir, Mehmet Emin AU - Aydemir ME AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. Electronic address: aydemiremin23@harran.edu.tr. FAU - Giraz, Mehmet Nuri AU - Giraz MN AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. FAU - Tugbay, Emine Betul AU - Tugbay EB AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. FAU - Altun, Serap Kilic AU - Altun SK AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. FAU - Yalcin, Hamza AU - Yalcin H AD - Department of Animal Science, Faculty of Agriculture, Harran University, Sanliurfa, Turkiye. LA - eng PT - Journal Article DEP - 20260713 PL - Netherlands TA - Regul Toxicol Pharmacol JT - Regulatory toxicology and pharmacology : RTP JID - 8214983 RN - 0 (Bisphenol A Compounds) RN - 0 (Phenols) RN - MLT3645I99 (bisphenol A) RN - 0 (Benzhydryl Compounds) RN - 0 (Endocrine Disruptors) SB - IM MH - Bisphenol A Compounds MH - *Phenols/analysis MH - Monte Carlo Method MH - Risk Assessment MH - *Benzhydryl Compounds/analysis MH - Humans MH - *Food Contamination/analysis MH - *Spices/analysis MH - Turkey MH - *Endocrine Disruptors/analysis OTO - NOTNLM OT - Bisphenol A OT - ELISA OT - Isot spice OT - Monte Carlo simulation OT - Risk assessment COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/14 04:10 MHDA- 2026/08/01 00:36 CRDT- 2026/07/13 19:12 PHST- 2025/10/15 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/01 00:36 [medline] PHST- 2026/07/14 04:10 [pubmed] PHST- 2026/07/13 19:12 [entrez] AID - S0273-2300(26)00152-2 [pii] AID - 10.1016/j.yrtph.2026.106179 [doi] PST - ppublish SO - Regul Toxicol Pharmacol. 2026 Nov;171:106179. doi: 10.1016/j.yrtph.2026.106179. Epub 2026 Jul 13. PMID- 42442506 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260806 IS - 1872-7697 (Electronic) IS - 0167-8760 (Linking) VI - 227 DP - 2026 Sep TI - Orientation ensemble perception is highly dependent on spatial attention. PG - 113439 LID - S0167-8760(26)00122-4 [pii] LID - 10.1016/j.ijpsycho.2026.113439 [doi] AB - The visual world is complex; however, we still access its richness despite computational limits in our visual system. Ensemble perception overcomes this bottleneck by extracting statistics, such as the mean, standard deviation, or other distributional characteristics, of feature sets like orientations or facial expressions, without processing each object individually. The role of attention in ensemble processing is debated: can we extract statistical information about a set when we do not attend to it? To address this question, we used the Posner cueing paradigm in which participants (N = 30, Mean Age = 19.6) reported the orientation of a single Gabor patch or the mean orientation of an ensemble of Gabors. Ensembles consisted of several Gabors whose orientations were sampled from a truncated Gaussian distribution centered on a clockwise or counterclockwise mean. A central arrow pre-cue pointed to either the right or left prior to bilateral stimulus presentation, and a post-cue indicated which side should be reported. In 20% of trials, the post-cued location differed from the pre-cued, so attention was misdirected (invalid trials); in others, cues aligned (valid trials). We used EEG to confirm attentional deployment to the cued location, and we used behavioral measures to estimate the effect of such attentional orientation. We looked for the N2pc, an EEG marker of lateralized attention, but could only detect it in the single Gabor condition. However, multivariate pattern analysis (MVPA) confirmed attentional shifts by showing above-chance classification accuracy of the attended side in both single and ensemble conditions. Behavioral performance was measured using d', a measure of sensitivity. Performance was impaired on invalid compared to valid trials in both the single Gabor and ensemble conditions, consistent with a role of attention in both cases. Accuracy dropped to chance levels on invalid ensemble trials but remained above chance, though reduced, on single trials. Overall, these findings indicate that misdirecting spatial attention severely impairs the ability to report the mean orientation of peripherally presented ensembles. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Lukashevich, Anton AU - Lukashevich A AD - Department of Psychology, University of Iceland, Iceland. Electronic address: antonlukashevich@hi.is. FAU - Utochkin, Igor AU - Utochkin I AD - Institute for Mind and Biology, University of Chicago, United States. FAU - Hansmann-Roth, Sabrina AU - Hansmann-Roth S AD - Department of Psychology, University of Iceland, Iceland. FAU - Sigurdardottir, Heida Maria AU - Sigurdardottir HM AD - Department of Psychology, University of Iceland, Iceland. LA - eng PT - Journal Article DEP - 20260713 PL - Netherlands TA - Int J Psychophysiol JT - International journal of psychophysiology : official journal of the International Organization of Psychophysiology JID - 8406214 SB - IM MH - Humans MH - *Attention/physiology MH - Female MH - Male MH - Young Adult MH - Electroencephalography MH - *Space Perception/physiology MH - Cues MH - Adult MH - Photic Stimulation MH - *Pattern Recognition, Visual/physiology MH - Adolescent MH - *Orientation, Spatial/physiology OTO - NOTNLM OT - Cueing OT - Ensemble perception OT - N2pc OT - Spatial attention COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/07/14 04:10 MHDA- 2026/08/07 00:35 CRDT- 2026/07/13 19:11 PHST- 2025/09/30 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/07 00:35 [medline] PHST- 2026/07/14 04:10 [pubmed] PHST- 2026/07/13 19:11 [entrez] AID - S0167-8760(26)00122-4 [pii] AID - 10.1016/j.ijpsycho.2026.113439 [doi] PST - ppublish SO - Int J Psychophysiol. 2026 Sep;227:113439. doi: 10.1016/j.ijpsycho.2026.113439. Epub 2026 Jul 13. PMID- 42442333 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260824 IS - 1873-5150 (Electronic) IS - 0887-8994 (Linking) VI - 182 DP - 2026 Sep TI - The Association Between Polyphenols Intake of Pregnant Mothers and Neurodevelopment Indices in Their Children: The Prospective Epidemiological Research Studies in Iran Birth Cohort-Isfahan. PG - 73-80 LID - S0887-8994(26)00188-8 [pii] LID - 10.1016/j.pediatrneurol.2026.06.015 [doi] AB - BACKGROUND: Polyphenol intake is important for neurological health; however, limited evidence has examined the association between maternal dietary polyphenol intake during pregnancy and children's neurodevelopment. This study aimed to investigate the relationship between maternal polyphenol consumption across pregnancy trimesters and neurodevelopmental outcomes in children. METHODS: This prospective cohort study included 945 mother-child pairs from the Isfahan Birth Cohort. Maternal dietary intake was assessed using a validated 90-item food frequency questionnaire. Polyphenol intake was estimated using the Phenol-Explorer database. Children's neurodevelopment and behavioral outcomes were evaluated using the Ages and Stages Questionnaire and the Child Behavior Checklist. RESULTS: Higher maternal polyphenol intake during the first trimester was associated with lower odds of adverse behavioral outcomes at 2 years of age. In adjusted models, the second (odds ratio [OR]: 0.370, 95% confidence interval [CI]: 0.197-0.693) and third tertiles (OR: 0.523, 95% CI: 0.297-0.920) of polyphenol intake were associated with reduced odds compared to the lowest tertile. Similar associations were observed for the second tertile of polyphenol intake during the first trimester (OR: 0.317, 95% CI: 0.123-0.816) and third trimester (OR: 0.380, 95% CI: 0.152-0.954). No consistent associations were observed at later follow-up ages. CONCLUSIONS: Higher maternal polyphenol intake during pregnancy, particularly in early gestation, may be associated with more favorable early neurodevelopmental and behavioral outcomes. However, these associations were not consistent across all ages, and causality cannot be inferred. Further studies using objective measures of polyphenol exposure and long-term follow-up are warranted. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Amini-Kahrizsangi, Masoud AU - Amini-Kahrizsangi M AD - Nutrition and Food Security Research Center, Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Nouri, Fatemeh AU - Nouri F AD - Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Heidari-Beni, Motahar AU - Heidari-Beni M AD - Child Growth and Development Research Center, Department of Nutrition, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: heidari.motahar@gmail.com. FAU - Rouhani, Mohammad Hossein AU - Rouhani MH AD - Nutrition and Food Security Research Center, Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Kelishadi, Roya AU - Kelishadi R AD - Child Growth and Development Research Center, Department of Nutrition, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20260625 PL - United States TA - Pediatr Neurol JT - Pediatric neurology JID - 8508183 RN - 0 (Polyphenols) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Polyphenols/administration & dosage MH - Iran/epidemiology MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Neurodevelopment MH - Prospective Studies MH - Child, Preschool MH - *Child Development/physiology MH - Adult MH - Birth Cohort MH - Developmental Origins of Health and Disease OTO - NOTNLM OT - Children OT - Neurodevelopment OT - Polyphenols OT - Pregnancy COIS- Fundings This study was conducted as the project number 3403325 supported by Isfahan University of Medical Sciences. EDAT- 2026/07/14 04:10 MHDA- 2026/08/24 23:34 CRDT- 2026/07/13 18:10 PHST- 2025/08/31 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/24 23:34 [medline] PHST- 2026/07/14 04:10 [pubmed] PHST- 2026/07/13 18:10 [entrez] AID - S0887-8994(26)00188-8 [pii] AID - 10.1016/j.pediatrneurol.2026.06.015 [doi] PST - ppublish SO - Pediatr Neurol. 2026 Sep;182:73-80. doi: 10.1016/j.pediatrneurol.2026.06.015. Epub 2026 Jun 25. PMID- 42442126 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1724-191X (Electronic) IS - 1120-1797 (Linking) VI - 148 DP - 2026 Aug TI - Integration of site-specific deep learning models for automated OAR segmentation in craniospinal proton therapy: a geometric and dosimetric analysis. PG - 105872 LID - S1120-1797(26)00159-6 [pii] LID - 10.1016/j.ejmp.2026.105872 [doi] AB - PURPOSE: This study evaluated the feasibility of integrating RayStation deep learning auto-segmentation (DLS) models-originally trained for adult head and neck (HN), thorax-abdomen (TA), and male pelvis (MP) regions-for automated organs-at-risk (OARs) delineation in craniospinal irradiation (CSI) with intensity-modulated-proton-therapy (IMPT), focusing on geometric accuracy, dosimetric impact, and clinical efficiency. METHODS: Forty patients (aged 2-28 years) with CNS embryonal tumors were retrospectively analyzed. Their planning CT datasets were sequentially processed through the HN, TA, and MP DLS models to auto-segment 60 OARs. Thirty-one OARs were compared with expert contours using Dice Similarity Coefficient (DSC) and Hausdorff Distance (HD). Spearman's rank correlation was used to examine associations between geometric metrics and patient age, BMI, and craniospinal length. Dosimetric evaluation was performed by recalculating IMPT plans on DLS-derived OARs. RESULTS: The mean auto-segmentation time was 4.9 +/- 1.0 min per patient. Across 31 OARs, mean DSC and HD were 0.73 and 2.45 mm, with 41.9 % and 93.5 % meeting good geometric criteria (DSC > 0.8, HD < 4 mm). Geometric accuracy showed significant correlations (p < 0.05) with age, BMI, and craniospinal length for up to 11 OARs. Accuracy decreased in children (<12 years), especially for the thyroid, bowel, and pelvic structures. Mean and maximum dose deviations were within 105 and 190 cGy(RBE), except for the mandible, esophagus, and anorectum. CONCLUSION: The integrated DLS framework achieved reliable geometric and dosimetric performance across most OARs with substantial efficiency gains, offering a practical solution for rapid, standardization of CSI planning workflows under expert review. CI - Copyright (c) 2026 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved. FAU - Gayen, Sanjib AU - Gayen S AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Sharma, Dayananda Shamurailatpam AU - Sharma DS AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. Electronic address: drdayananda_s@apollohospitals.com. FAU - Singh, Gaganpreet AU - Singh G AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Krishnan, Ganapathy AU - Krishnan G AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Arjunan, Manikandan AU - Arjunan M AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Mahammood, Suhail AU - Mahammood S AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - S, Rangasamy AU - S R AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - M, Shakthivel AU - M S AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Krishna, Uday AU - Krishna U AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Sundar, Sham AU - Sundar S AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Chilukuri, Srinivas AU - Chilukuri S AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Jalali, Rakesh AU - Jalali R AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260713 PL - Italy TA - Phys Med JT - Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) JID - 9302888 SB - IM MH - Humans MH - *Proton Therapy/adverse effects MH - Child MH - Child, Preschool MH - *Craniospinal Irradiation/adverse effects MH - Adolescent MH - *Organs at Risk/radiation effects MH - Radiometry MH - *Deep Learning MH - Male MH - Adult MH - Radiotherapy Dosage MH - Young Adult MH - Radiotherapy Planning, Computer-Assisted/methods MH - Automation MH - Retrospective Studies MH - *Image Processing, Computer-Assisted/methods MH - Female OTO - NOTNLM OT - Craniospinal Irradiation OT - Deep learning auto-segmentation OT - Proton beam therapy COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/14 04:10 MHDA- 2026/08/08 00:40 CRDT- 2026/07/13 18:04 PHST- 2025/10/07 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/08 00:40 [medline] PHST- 2026/07/14 04:10 [pubmed] PHST- 2026/07/13 18:04 [entrez] AID - S1120-1797(26)00159-6 [pii] AID - 10.1016/j.ejmp.2026.105872 [doi] PST - ppublish SO - Phys Med. 2026 Aug;148:105872. doi: 10.1016/j.ejmp.2026.105872. Epub 2026 Jul 13. PMID- 42441631 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260820 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Capturing women's bodily experiences: Conception and formative stages of the women's somatic experience inventory. PG - e0353167 LID - 10.1371/journal.pone.0353167 [doi] LID - e0353167 AB - Assessment of women's bodily experiences is used primarily to characterize negative psychological features of menstruation. However, women's somatic states span a full spectrum of valence, emanate from multiple body systems, and affect physical and psychological well-being every day, throughout life and a more complete understanding of these states is important for the advancement of the science of women. This study presents the conception and formative stages of a comprehensive inventory about women's somatic states, bodily experiences, and physical perceptions to be called the Women's Somatic Experience Inventory. Three hundred biologically female university students (ages 18-25) rated the frequency and valence of diverse somatic experiences. An iterative approach was used: a systematic review compiled somatic items, variable clustering techniques reduced items, and confirmatory factor analysis and structural equation modeling guided factor refinement and proof-of-concept. Nine unpleasant latent factors (Kinesthetic Disconnect, Generalized Pain, Gastrointestinal Distress, Illness, Low Energy, Neurological Discomfort, Metabolic Stress, Heat & Urgency Response, and Sympathetic Activation) and four pleasant latent factors (Physical Alignment, Physical Intimacy, Activated & Attractive, and Parasympathetic Activation) were identified. Validated surveys of premenstrual symptoms and body awareness, use of hormonal contraception, and exercise and alcohol use behaviors were associated with pleasant and unpleasant factors, serving as initial proof-of-concept. These results support further refinement of the factors to be included in the inventory. With further testing and validation, the identified 73 somatic items and 13 factors could form the Women's Somatic Experience Inventory, the first comprehensive inventory for understanding women's somatic experiences, how these experiences change across female reproductive life stages, and how they interact with lifestyle behaviors. CI - Copyright: (c) 2026 Piersol et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Piersol, Kelsey L AU - Piersol KL AUID- ORCID: 0000-0002-3620-3753 AD - Department of Kinesiology and Health, Rutgers University-New Brunswick, New Jersey, United States of America. FAU - Colangelo, Amanda P AU - Colangelo AP AD - Department of Kinesiology and Health, Rutgers University-New Brunswick, New Jersey, United States of America. FAU - Buckman, Jennifer F AU - Buckman JF AUID- ORCID: 0000-0002-1898-5499 AD - Department of Kinesiology and Health, Rutgers University-New Brunswick, New Jersey, United States of America. LA - eng GR - F31 AA030178/AA/NIAAA NIH HHS/United States GR - R01 AA027017/AA/NIAAA NIH HHS/United States PT - Journal Article DEP - 20260713 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Young Adult MH - *Body Image/psychology MH - Body Satisfaction MH - Menstruation/psychology MH - Surveys and Questionnaires PMC - PMC13362119 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/13 22:44 MHDA- 2026/07/13 22:45 PMCR- 2026/07/13 CRDT- 2026/07/13 13:44 PHST- 2025/05/16 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/07/13 22:45 [medline] PHST- 2026/07/13 22:44 [pubmed] PHST- 2026/07/13 13:44 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - PONE-D-25-18681 [pii] AID - 10.1371/journal.pone.0353167 [doi] PST - epublish SO - PLoS One. 2026 Jul 13;21(7):e0353167. doi: 10.1371/journal.pone.0353167. eCollection 2026. PMID- 42441364 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 0918-5739 (Print) IS - 1347-7358 (Electronic) IS - 0918-5739 (Linking) VI - 35 IP - 3 DP - 2026 Jul TI - Hematopoietic stem cell transplantation-associated partial lipodystrophy. PG - 201-214 LID - 10.1297/cpe.2026-0005 [doi] AB - Hematopoietic stem cell transplantation (HSCT)-associated partial lipodystrophy (HSCT-PL) is a serious metabolic complication that develops in remote period among childhood cancer survivors treated with HSCT with total body irradiation (TBI). Since the first proposal in 2013, HSCT-PL seems to be increasingly recognized as a distinct disease entity. The patients with HSCT-PL show profound metabolic dysfunction including insulin resistance, diabetes, elevated triglycerides, and hepatic steatosis. Their body mass index is low-normal, although they show visceral fat accumulation and increased waist-to-hip ratio. In addition, HSCT-PL is characterized by Dunnigan phenotype: lipoatrophy in buttock and extremities combined with lipohypertrophy in face and neck. Although the precise pathogenesis is still obscure, radiation-induced damage to adipose progenitor cells, leading to accelerated senescence, seems to be a main pathway. Literature survey identified 17 patients of HSCT-PL with sufficient information from 12 reports. Among them, clear female predominance (15 females) and possible ethnic difference in disease prevalence (11 Japanese) were ascertained. Genetic factors may be involved in those epidemiological traits. There remains much to be clarified, including establishment of reliable diagnostic procedure, elucidation of long-term prognosis, and invention of effective treatment. Metreleptin is one of the promising options, and the accumulation of its therapeutic efficacy are warranted. CI - 2026(c)The Japanese Society for Pediatric Endocrinology. FAU - Adachi, Masanori AU - Adachi M AD - Department of Pediatrics, Showa Medical University, Tokyo, Japan. LA - eng PT - Journal Article PT - Review DEP - 20260326 PL - Japan TA - Clin Pediatr Endocrinol JT - Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology JID - 9433330 PMC - PMC13337291 OTO - NOTNLM OT - Danforth's hypothesis OT - adipose progenitor cell OT - graft versus host disease OT - sarcopenia OT - total body irradiation COIS- The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/13 23:38 MHDA- 2026/07/13 23:39 PMCR- 2026/07/01 CRDT- 2026/07/13 12:50 PHST- 2026/01/09 00:00 [received] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/07/13 23:39 [medline] PHST- 2026/07/13 23:38 [pubmed] PHST- 2026/07/13 12:50 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 2026-0005 [pii] AID - 10.1297/cpe.2026-0005 [doi] PST - ppublish SO - Clin Pediatr Endocrinol. 2026 Jul;35(3):201-214. doi: 10.1297/cpe.2026-0005. Epub 2026 Mar 26. PMID- 42441015 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2949-7612 (Electronic) IS - 2949-7612 (Linking) VI - 4 IP - 3 DP - 2026 Sep TI - Application Usability, Engagement, and Postpartum Weight Retention: Secondary Analysis of the INTER-ACT Randomized Controlled Trial. PG - 100381 LID - 10.1016/j.mcpdig.2026.100381 [doi] LID - 100381 AB - OBJECTIVE: To examine whether perceived usability of the INTER-ACT application influences postpartum weight loss and whether this effect is mediated by application use, motivational power, and implementation of lifestyle recommendations. PATIENTS AND METHODS: Dutch-speaking women aged 18 years or older who had delivered a singleton infant and exceeded the recommended guidelines of the Institute of Medicine for gestational weight gain got recruited from May 2017 to April 2019, Across 6 Flemish hospitals. This secondary analysis included 138 participants of the INTER-ACT intervention arm. At 6 months postpartum participants completed a process evaluation survey, assessing application usability using the system usability scale, perceived motivational power, and perceived implementation of lifestyle recommendations. Weight loss was calculated between 6 weeks and 6 months postpartum. Pearson correlations and parallel mediation analyses were conducted, adjusting for maternal age, parity, and prepregnancy body mass index. RESULTS: Application usability was moderate (mean system usability scale=60.6) and positively associated with perceived application use frequency (B=.05, P<.001), motivational power (B=.003, P<.001), and implementation of lifestyle recommendations (B=.01, P=.036), but not with weight loss. Usability showed no total, direct, or indirect effect on weight loss. Gestational weight gain (GWG) was the only significant predictor (B=0.24, P=.003). Higher usability was also associated with more positive and fewer negative emotional responses (P<.05). CONCLUSION: Application usability was associated with engagement and positive emotional experience, but not with reduced PPWR. The GWG remained the main determinant of postpartum weight outcomes. Preventing excessive GWG and complementing this with emotionally supportive postpartum mHealth tools may improve outcomes. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT02989142. CI - (c) 2026 The Authors. FAU - Duizer, Lisanne AU - Duizer L AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Department of Clinical Child and Family Studies, Vrije Universiteit Amsterdam, The Netherlands. FAU - Geusens, Femke AU - Geusens F AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Geerits, Emma AU - Geerits E AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - REVAL Rehabilitation Research Center, UHasselt, Diepenbeek, Belgium. FAU - Devlieger, Roland AU - Devlieger R AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium. AD - Department of Obstetrics, Gynecology and Reproduction, St-Augustinus Hospital, Wilrijk, Belgium. FAU - Bogaerts, Annick AU - Bogaerts A AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Faculty of Health, University of Plymouth, Devon, United Kingdom. LA - eng SI - ClinicalTrials.gov/NCT02989142 PT - Journal Article DEP - 20260609 PL - Netherlands TA - Mayo Clin Proc Digit Health JT - Mayo Clinic proceedings. Digital health JID - 9918662584506676 PMC - PMC13334793 COIS- The authors report no competing interests. EDAT- 2026/07/13 22:55 MHDA- 2026/07/13 22:56 PMCR- 2026/06/09 CRDT- 2026/07/13 12:37 PHST- 2026/07/13 22:56 [medline] PHST- 2026/07/13 22:55 [pubmed] PHST- 2026/07/13 12:37 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - S2949-7612(26)00047-7 [pii] AID - 100381 [pii] AID - 10.1016/j.mcpdig.2026.100381 [doi] PST - epublish SO - Mayo Clin Proc Digit Health. 2026 Jun 9;4(3):100381. doi: 10.1016/j.mcpdig.2026.100381. eCollection 2026 Sep. PMID- 42440919 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2673-4915 (Electronic) IS - 2673-4915 (Linking) VI - 7 DP - 2026 TI - Caries risk in toddlers: assessing oral health, microbial factors, and maternal transmission. PG - 1847228 LID - 10.3389/fdmed.2026.1847228 [doi] LID - 1847228 AB - OBJECTIVES: Caries risk begins early in life, yet few studies use intraoral cameras to assess risk in toddlers or examine multiple contributing factors. This study aimed to address this gap and conduct intraoral camera-based assessment of caries and evaluate multiple toddler risk factors, including microbial profiles, oral hygiene practices, and potential maternal transmission. METHODS: Cross-sectional data from 21 maternal-child dyads included intraoral camera assessments coded with an adapted International Caries Detection and Assessment System, saliva-based microbial tests for Streptococcus mutans (SM) and Lactobacillus (LB), and validated surveys of hygiene practices. RESULTS: Among toddlers (N = 21; mean age 3.9 years), intraoral camera use was well tolerated and produced images adequate for assessment. Reliability was good for sound teeth [Intraclass correlation coefficient (ICC) = 0.80], moderate for initial caries (ICC = 0.72), and poor for moderate-to-severe caries (ICC = 0.13). Most teeth were sound (89.0%), with 9.8% mild and 1.1% moderate decay. SM was detected in 9/20 (45.0%) and LB in 4/21 (19.0%) of toddlers. While 81% brushed twice daily, few flossed (14.3%) or used mouthwash (19%); 42.1% consumed soda at least weekly and 19% ate fast food weekly. More frequent brushing was associated with lower SM (Cramer's V = 0.54; p = .02) and LB (V = 0.48; p = .043). Mothers (N = 21; mean age 32.1) had 38.0% of teeth coded as sound, 45.0% with initial caries, and 14.0% with moderate-to-severe decay; 9/21 (42.9%) tested positive for LB and the same proportion tested positive for SM. Most brushed twice daily (81%), with 47.6% flossing and 38.1% using mouthwash. Maternal and toddler brushing frequency (V = 0.68; p = .02), fast-food intake (V = 0.56; p = .01), and microbial positivity (SM: V = 0.93; p = .001; LB: V = 0.54; p = .02) were strongly related. CONCLUSIONS: Intraoral cameras with adapted ICDAS scoring were feasible for assessing caries risk in toddlers. Significant concordance between maternal and child microbial profiles suggests a potential maternal influence on early caries risk. Larger longitudinal studies are needed to clarify transmission pathways and inform prevention strategies. CI - (c) 2026 Scudero, Manning, Mariscal, McNulty, Fidopiastis, Fardanesh, Heaney and Phelan. FAU - Scudero, Emma AU - Scudero E AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Manning, Nolan AU - Manning N AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Mariscal, Vanessa T AU - Mariscal VT AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - McNulty, Molly AU - McNulty M AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Fidopiastis, Pat AU - Fidopiastis P AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Fardanesh, Navid AU - Fardanesh N AD - Community Health Centers of the Central Coast, San Luis Obispo, CA, United States. FAU - Heaney, Casey AU - Heaney C AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Phelan, Suzanne AU - Phelan S AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. LA - eng PT - Journal Article DEP - 20260622 PL - Switzerland TA - Front Dent Med JT - Frontiers in dental medicine JID - 101777956 PMC - PMC13333731 OTO - NOTNLM OT - ICDAS OT - intraoral camera OT - maternal transmission OT - oral health OT - toddler COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/13 23:35 MHDA- 2026/07/13 23:36 PMCR- 2026/06/22 CRDT- 2026/07/13 12:32 PHST- 2026/04/06 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/13 23:36 [medline] PHST- 2026/07/13 23:35 [pubmed] PHST- 2026/07/13 12:32 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fdmed.2026.1847228 [doi] PST - epublish SO - Front Dent Med. 2026 Jun 22;7:1847228. doi: 10.3389/fdmed.2026.1847228. eCollection 2026. PMID- 42440894 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Systematic review of metabolism and safety aspects of monosodium glutamate intake in infants and lactating mothers: a scientific and regulatory perspective. PG - 1825764 LID - 10.3389/fnut.2026.1825764 [doi] LID - 1825764 AB - BACKGROUND: Monosodium glutamate (MSG) is widely used as a flavor enhancer, and its safety has been extensively studied for decades, providing a robust evidence base. Scientific discourse has focused on its effects on neurodevelopment, metabolism, and specific populations, such as neonates, and these effects have been carefully evaluated. Regulatory agencies worldwide have periodically revisited the evidence base, emphasizing the need for updated, balanced assessments. Following PRISMA 2020 guidelines, we searched PubMed, Embase, Scopus, Web of Science, and the Cochrane Library up to August 2025. Eligible studies included randomized controlled trials (RCTs), observational studies, preclinical investigations, and regulatory assessments. Two independent reviewers screened 3,800 records, with moderate inter-rater agreement (Cohen's kappa = 0.40), resolving all discrepancies through consensus. Data were synthesized narratively due to heterogeneity. Risk of bias was assessed using standard tools (RoB 2, Newcastle-Ottawa, SYRCLE, and narrative appraisal). RESULTS: Thirty-five studies and regulatory reports met inclusion criteria: 2 RCTs, observational studies (n = 16), preclinical studies (n = 8), and regulatory evaluations (n = 9). An additional 39 references provide an informed background and mechanistic context. Human studies have consistently shown efficient MSG metabolism, stable glutamate levels in breast milk, irrespective of maternal intake, and no adverse outcomes at dietary exposures. Regulatory evaluations confirmed safety, and animal studies confirmed safety at dietary levels, with effects observed only under extreme, non-physiological conditions. The risk of bias was low to moderate in human studies but higher in animal studies due to the indirectness of exposure models. Regulatory evaluations were primarily of low risk. CONCLUSION: Current evidence indicates that MSG is safe. Future research may further refine our understanding of developmental physiology and sensitive populations, building on the strong foundation of current evidence. A balanced interpretation of evidence is crucial for guiding public health communication and regulatory decision-making. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251239310. CI - Copyright (c) 2026 Sengupta, Mallick and Yadav. FAU - Sengupta, Trina AU - Sengupta T AD - Department of Physiology, ESI-PGIMSR Medical College and Hospital, Joka, Kolkata, India. FAU - Mallick, Hruda Nanda AU - Mallick HN AD - Retired, Gurugram, India. FAU - Yadav, Raj Kumar AU - Yadav RK AD - Department of Physiology, All India Institute of Medical Sciences, New Delhi, India. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260622 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13333772 OTO - NOTNLM OT - evidence-based practice OT - flavoring agents OT - food safety OT - human milk OT - infant OT - maternal exposure OT - newborn OT - sodium glutamate COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author HM declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/07/13 23:38 MHDA- 2026/07/13 23:39 PMCR- 2026/06/22 CRDT- 2026/07/13 12:31 PHST- 2026/03/08 00:00 [received] PHST- 2026/05/25 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/07/13 23:39 [medline] PHST- 2026/07/13 23:38 [pubmed] PHST- 2026/07/13 12:31 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fnut.2026.1825764 [doi] PST - epublish SO - Front Nutr. 2026 Jun 22;13:1825764. doi: 10.3389/fnut.2026.1825764. eCollection 2026. PMID- 42440723 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Morphofunctional markers to assess disease-related pediatric malnutrition at admission and their association with length of hospital stay. PG - 1741856 LID - 10.3389/fnut.2026.1741856 [doi] LID - 1741856 AB - BACKGROUND: Disease-related malnutrition (DRM) occurs due to energy imbalance caused by increased catabolism, decreased appetite, or increased energy losses. In hospitalized patients, the presence of DRM can increase morbidity, disability, and mortality, as well as delay recovery from the disease. Therefore, identifying accurate nutritional markers associated with length of stay (LOS) in pediatric patients is important. OBJECTIVE: The objective of this study was to explore the association between morphofunctional markers used to evaluate DRM upon hospital admission and LOS in pediatric patients. METHODS: Exploratory, single-center prospective cohort study was performed in a single center study with patients evaluated within 24-48 h of a third level pediatric hospital. Upon hospital admission, nutritional risk was determinate risk nutritional status screening, anthropometric measurements were made such as weight, height, mid-upper arm circumference (MUAC), calf circumference (CC); body composition with bioelectrical impedance analysis (BIA) and handgrip strength (HGS) was carried out. DRM was diagnosed based on body mass index-for-age z-score (BMIz) < -2 standard deviations (SD). RESULTS: A total of 139 pediatric patients (mean age 12.1 +/- 3.3 years) were included; DRM was present in 15.8%. Among patients with DRM, those who concomitantly presented low phase angle (PhA), low CC, and low HGS had a significantly longer median LOS [15 (5-27) days] than those with values above the established cutoff points [(8 (5-13) days], (p = 0.029). CONCLUSION: In pediatric patients with DRM, lower levels of morphofunctional markers (PhA, HGS, and CC) at hospital admission were associated with prolonged hospital stay. These findings, derived from a Mexican pediatric population, warrant external validation in larger and more diverse cohorts. CI - Copyright (c) 2026 Garcia-Guzman, Pinzon-Navarro, Baldwin-Monroy, Ortiz-Gutierrez, Guevara-Cruz, Avila-Nava and Medina-Vera. FAU - Garcia-Guzman, Alda Daniela AU - Garcia-Guzman AD AD - Servicio de Oncologia Medica, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. FAU - Pinzon-Navarro, Beatriz Adriana AU - Pinzon-Navarro BA AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Servicio de Gastroenterologia y Nutricion Pediatrica, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. FAU - Baldwin-Monroy, Daffne Danae AU - Baldwin-Monroy DD AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Unidad de Terapia Intensiva, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. FAU - Ortiz-Gutierrez, Salvador AU - Ortiz-Gutierrez S AD - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Mexico. AD - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional (IPN), Ciudad de Mexico, Mexico. FAU - Guevara-Cruz, Martha AU - Guevara-Cruz M AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Mexico. FAU - Avila-Nava, Azalia AU - Avila-Nava A AD - Hospital Regional de Alta Especialidad Peninsula de Yucatan, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-Bienestar), Merida, Yucatan, Mexico. FAU - Medina-Vera, Isabel AU - Medina-Vera I AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Departamento de Metodologia de la Investigacion, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. LA - eng PT - Journal Article DEP - 20260622 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13333472 OTO - NOTNLM OT - body composition OT - disease-related malnutrition OT - hospital admission OT - pediatric OT - phase angle COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author MG-C declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/07/13 22:43 MHDA- 2026/07/13 22:44 PMCR- 2026/06/22 CRDT- 2026/07/13 12:24 PHST- 2025/11/07 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/07/13 22:44 [medline] PHST- 2026/07/13 22:43 [pubmed] PHST- 2026/07/13 12:24 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fnut.2026.1741856 [doi] PST - epublish SO - Front Nutr. 2026 Jun 22;13:1741856. doi: 10.3389/fnut.2026.1741856. eCollection 2026. PMID- 42440670 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Associations of smartphone addiction and physical activity with sleep quality and neck/shoulder symptoms in university students: a cross-sectional study. PG - 1848640 LID - 10.3389/fpubh.2026.1848640 [doi] LID - 1848640 AB - OBJECTIVE: To examine the associations of smartphone addiction, physical activity, and sedentary time with sleep quality and neck/shoulder symptoms during the previous 7 days in university students, and to assess the potential modifying role of physical activity in outcomes associated with smartphone addiction. METHODS: A cross-sectional survey was conducted among 585 students from a single university in Jilin Province, China. Smartphone addiction, physical activity, sedentary time, sleep quality, and neck/shoulder symptoms were assessed using validated questionnaires. Multivariable linear regression and Poisson regression with robust variance were used to examine adjusted associations and interaction terms. RESULTS: Of the participants, 43.8% were classified as having poor sleep, and 46.2% reported at least one neck/shoulder symptoms during the previous 7 days. After adjustment for covariates, higher smartphone addiction and longer sedentary time were both associated with higher PSQI scores, a higher prevalence of poor sleep, and a higher prevalence of neck/shoulder symptoms during the previous 7 days. Meeting physical activity recommendations was associated with lower PSQI scores and a lower prevalence of poor sleep, but showed no independent association with neck/shoulder symptoms. After further adjustment for PSQI, smartphone addiction, sedentary time, and PSQI score were still significantly associated with a higher prevalence of neck/shoulder symptoms. Interaction plots showed descriptively lower predicted PSQI scores and lower predicted probabilities of neck/shoulder symptoms among students who met physical activity recommendations at comparable levels of smartphone addiction; however, the formal interaction terms were not statistically significant. CONCLUSION: Smartphone addiction and sedentary time were consistently associated with poorer sleep quality and more frequent neck/shoulder symptoms. Physical activity was more consistently associated with sleep outcomes than with neck/shoulder symptoms. These findings support considering smartphone use, sedentary behaviour, physical activity, and sleep management together in campus health promotion research. CI - Copyright (c) 2026 Yue, Cao, Zhao, Wang, Lai, Zhang and Cui. FAU - Yue, Wei AU - Yue W AD - College of Physical Education, Jilin Normal University, Siping, Jilin, China. FAU - Cao, Shen AU - Cao S AD - Football School, Hebei Institute of Communications, Shijiazhuang, Hebei, China. FAU - Zhao, Jinglei AU - Zhao J AD - School of Culture, Tourism, Health and Wellness Education, Dongying Vocational College, Dongying, Shandong, China. FAU - Wang, Qin AU - Wang Q AD - School of Culture, Tourism, Health and Wellness Education, Dongying Vocational College, Dongying, Shandong, China. FAU - Lai, Weigang AU - Lai W AD - Sports Committee, Dongying Vocational College, Dongying, China. FAU - Zhang, Jinhui AU - Zhang J AD - Faculty of Education and Liberal Studies, City University Malaysia, Kuala Lumpur, Malaysia. FAU - Cui, Yuexin AU - Cui Y AD - Office of Academic Affairs, Dongying Vocational College, Dongying, China. LA - eng PT - Journal Article DEP - 20260622 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Students/statistics & numerical data/psychology MH - *Exercise MH - Male MH - Universities MH - *Shoulder Pain/epidemiology MH - *Sleep Quality MH - China/epidemiology MH - *Smartphone/statistics & numerical data MH - Young Adult MH - *Neck Pain/epidemiology MH - Surveys and Questionnaires MH - Sedentary Behavior MH - Adult MH - Adolescent MH - *Internet Addiction Disorder/epidemiology PMC - PMC13333704 OTO - NOTNLM OT - neck/shoulder symptoms OT - physical activity OT - sedentary behaviour OT - sleep quality OT - smartphone addiction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/13 23:35 MHDA- 2026/07/13 23:36 PMCR- 2026/06/22 CRDT- 2026/07/13 12:22 PHST- 2026/04/06 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/13 23:36 [medline] PHST- 2026/07/13 23:35 [pubmed] PHST- 2026/07/13 12:22 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1848640 [doi] PST - epublish SO - Front Public Health. 2026 Jun 22;14:1848640. doi: 10.3389/fpubh.2026.1848640. eCollection 2026. PMID- 42440326 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20261015 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 7 IP - 7 DP - 2026 Jul 13 TI - Physical activity for the management of obesity in children up to the age of 9 years. PG - CD015988 LID - 10.1002/14651858.CD015988 [doi] LID - CD015988 AB - RATIONALE: Childhood obesity is a major global public health concern. Although physical activity is recognised as an effective non-pharmacological intervention, most existing evidence synthesis has primarily focused on the role of physical activity in preventing obesity, with limited attention given to its effects on managing children with obesity. OBJECTIVES: To synthesise evidence on the benefits and harms of physical activity for the management of obesity in children up to 9 years of age. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, and two trial registries from 2012 to 2 June 2023, with an update on 4 December 2025. We also used Google Scholar to identify additional studies. We did not impose language or publication status restrictions. ELIGIBILITY CRITERIA: We included randomised controlled trials (RCTs) that investigated the effects of physical activity interventions of any frequency, mode (e.g. aerobic, resistance), or intensity, with a minimum intervention duration of 12 weeks, in children up to 9 years of age with obesity (as defined by the trialists) at baseline. Eligible comparators were standard care, waiting-list, no physical activity, or any other active interventions, such as comparisons of different physical activity parameters (e.g. duration, frequency, intensity). OUTCOMES: Critical outcomes: body mass index (BMI), BMI z-score, body weight, health-related quality of life, adiposity and fat distribution, glycaemia, and adverse events (minor and serious). Important outcomes: physical well-being, mental well-being, physical activity levels, blood pressure, hyperinsulinemia, resistance to insulin, alterations in lipid metabolism, presence of obesity-related comorbidities or any non-communicable diseases, obesity-associated disability, lipid hormones, alterations in hunger or satiety, disability, mortality, prevalence of obesity in adulthood, and access to health services. RISK OF BIAS: Pairs of review authors independently assessed the risk of bias in included studies using the original version of the Cochrane tool (RoB 1). SYNTHESIS METHODS: We synthesised results using meta-analysis when appropriate. Given the clinical and statistical heterogeneity, we predominantly used a random-effects model alongside sensitivity analyses. When meta-analysis was not feasible, we employed synthesis without meta-analysis (SWiM) methods. We assessed the certainty of the evidence using the GRADE approach. INCLUDED STUDIES: We included four studies (five references, 517 children; female 46%; mean age ranged from 8.9 to 9.9) conducted in three countries (the USA, Brazil, and Iran). Three studies (75%) delivered the physical activity interventions in school settings. Three studies (75%) compared physical activity interventions with non-exercise controls, while one compared physical activity with a behaviour-changing intervention. The duration of physical activity interventions ranged from 12 to 32 weeks. We assessed three studies as having an overall high risk of bias. SYNTHESIS OF RESULTS: Physical activity interventions compared to control The evidence is very uncertain about the effect of physical activity interventions on BMI (mean difference (MD) -1.52 kg/m(2), 95% confidence interval (CI) -2.74 to -0.29; I(2) = 0%; 2 studies, 118 children; very low-certainty evidence), BMI z-scores (MD -0.10 z-score units, 95% CI -0.22 to 0.02; I(2) = 29%; 1 study, 222 children; very low-certainty evidence), body weight (MD -0.86 kg, 95% CI -3.17 to 1.46; I(2) = 0%; 2 studies, 118 children; very low-certainty evidence), health-related quality of life (MD -0.60 points, 95% CI -4.22 to 3.02; 1 study, 175 children; very low-certainty evidence), adiposity and fat distribution, assessed as body fat percentage (MD -1.23%, 95% CI -2.50 to 0.03; I(2) = 0%; 3 studies, 456 children; very low-certainty evidence), minor adverse events (risk ratio (RR) 3.58, 95% CI 1.95 to 6.55; 1 study, 222 children; very low-certainty evidence), and serious adverse events (RR 1.08, 95% CI 0.10 to 11.76; 1 study, 222 children; very low-certainty evidence). No studies assessed glycaemia. Combined training (aquatic exercises) versus combined training (video game exercises) The evidence is very uncertain about the effect of combined training in an aquatic setting compared to video-game-based combined training on BMI (MD -0.90 kg/m(2), 95% CI -3.21 to 1.41; 1 study, 39 children; very low-certainty evidence), BMI at 4-week follow-up (MD 0.03 kg/m(2), 95% CI -2.54 to 2.60; 1 study, 39 children; very low-certainty evidence), body weight (MD -1.30 kg, 95% CI -5.66 to 3.06; 1 study, 39 children; very low-certainty evidence), and body weight at 4-week follow-up (MD -0.70 kg, 95% CI -5.70 to 4.30; 1 study, 39 children; very low-certainty evidence). This study did not assess the other critical outcomes. Low-dose versus high-dose combined training The evidence is very uncertain about the effect of low-dose versus high-dose combined training on BMI z-scores (MD 0.12 z-score units, 95% CI 0.10 to 0.14; 1 study, 144 children; very low-certainty evidence), adiposity and fat distribution, assessed as body fat percentage (MD 1.07%, 95% CI -0.74 to 2.88; 1 study, 144 children; very low-certainty evidence), glycaemia, assessed as fasting glucose level (MD -0.50 mg/dL, 95% CI -2.77 to 1.77; 1 study, 144 children; very low-certainty evidence), minor adverse events (RR 0.91, 95% CI 0.64 to 1.30; 1 study, 144 children; very low-certainty evidence), and serious adverse events (RR 3.08, 95% CI 0.13 to 74.45; 1 study, 144 children; very low-certainty evidence). This study did not assess the other critical outcomes. AUTHORS' CONCLUSIONS: The evidence from four randomised studies on the effects of physical activity interventions in children aged 0 to 9 with obesity is of very low certainty. Serious methodological limitations, clinical heterogeneity, small-study effects, and imprecise results constrained this evidence base. Important knowledge gaps remain because none of the included RCTs enroled children with disabilities. The RCTs provided little information on contextual factors. Future high-quality and better-reported RCTs will likely change our findings. FUNDING: The Department of Nutrition and Food Safety at the World Health Organization (WHO) commissioned and provided financial support for this work. WHO acknowledges financial support from the Norwegian Agency for Development Cooperation, the Swedish International Development Cooperation Agency, the Government of the Grand Duchy of Luxembourg, and the Government of Germany to the Department of Nutrition and Food Safety. REGISTRATION: Protocol available via https://doi.org/10.17605/OSF.IO/DSHUP. CI - Copyright (c) 2026 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. FAU - Loaiza-Betancur, Andres F AU - Loaiza-Betancur AF AUID- ORCID: 0000-0001-8258-8175 AD - JBI, School of Public Health, Adelaide University, Adelaide, Australia. FAU - Iglesias Gonzalez, Lisette Ethel AU - Iglesias Gonzalez LE AD - Fundacion Universitaria Maria Cano, Medellin, Colombia. FAU - Chavez Guapo, Nathaly AU - Chavez Guapo N AD - Facultad de Cultura Fisica, Deporte y Recreacion, Universidad Santo Tomas, Bogota, Colombia. FAU - Escobar Liquitay, Camila Micaela AU - Escobar Liquitay CM AD - Gestion de Informacion en Ciencias de la Salud, Instituto Universitario Hospital Italiano, Buenos Aires, Argentina. FAU - Bidonde, Julia AU - Bidonde J AD - School of Rehabilitation Science, College of Medicine, University of Saskatchewan, Saskatoon, Canada. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260713 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM MH - Humans MH - Child MH - Randomized Controlled Trials as Topic MH - *Exercise MH - *Pediatric Obesity/therapy MH - Child, Preschool MH - Body Mass Index MH - Quality of Life MH - Bias MH - Female PMC - PMC13361591 COIS- JB: none known. NCG: no relevant interests; WHO (grant/contract) - this review was conducted to inform one or more guideline recommendations on the 'Integrated management of adolescents 10 to 19 years of age with obesity in all their diversity: a primary health care approach for improved health, functioning and reduced obesity-associated disability'. The Department of Nutrition and Food Safety at the WHO commissioned and provided financial support for this work. CMEL: none known. LEIG: no relevant interests; WHO (grant/contract) - this review was conducted to inform one or more guideline recommendations on the 'Integrated management of adolescents 10 to 19 years of age with obesity in all their diversity: a primary health care approach for improved health, functioning and reduced obesity-associated disability'. The Department of Nutrition and Food Safety at the WHO commissioned and provided financial support for this work. AFLB: no relevant interests; WHO (grant/contract) - this review was conducted to inform one or more guideline recommendations on the 'Integrated management of adolescents 10 to 19 years of age with obesity in all their diversity: a primary health care approach for improved health, functioning and reduced obesity-associated disability'. The Department of Nutrition and Food Safety at the WHO commissioned and provided financial support for this work. EDAT- 2026/07/13 12:35 MHDA- 2026/07/13 12:36 PMCR- 2027/07/13 CRDT- 2026/07/13 11:34 PHST- 2026/07/13 12:36 [medline] PHST- 2026/07/13 12:35 [pubmed] PHST- 2026/07/13 11:34 [entrez] PHST- 2027/07/13 00:00 [pmc-release] AID - CD015988 [pii] AID - 10.1002/14651858.CD015988 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2026 Jul 13;7(7):CD015988. doi: 10.1002/14651858.CD015988. PMID- 42439710 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2047-7163 (Electronic) IS - 0036-8504 (Print) IS - 0036-8504 (Linking) VI - 109 IP - 3 DP - 2026 Jul-Sep TI - Diagnostic accuracy of ultrasound-based fetal weight estimation and prediction modeling for low birth weight: A retrospective cohort study in Northwest Ethiopia. PG - 368504261468514 LID - 10.1177/00368504261468514 [doi] LID - 00368504261468514 AB - ObjectiveTo evaluate the accuracy of ultrasound-based fetal weight estimation and to develop and internally validate a prediction model for low birth weight.MethodsA retrospective cohort study was conducted among 269 individuals.ResultsThe accuracy of ultrasound weight estimation was 72.9%, with 27.1% of estimates falling outside +/-10% of actual birth weight. The Pearson correlation for estimated fetal weight and actual birth weight was 0.92. Using LASSO regression eight predictors were selected and entered in the multivariable analysis of which gestational age, estimated fetal weight, timing of estimation, and placental location were found significant. The original model demonstrated strong discrimination of AUC of 95.9% 95%CI (93.1-98.0%), and good calibration. Internal validation via 1000-bootstrap resampling yielded a bias-corrected AUC of 94.3%, indicating preserved predictive performance with minimal optimism. An integer-based risk score was derived to enhance clinical usability. The risk score model achieved acceptable discrimination (AUC = 76.8%, 95% CI: 70.0-83.0%) and good calibration (p = 0.301). Agreement between the full prediction model and the simplified risk score was fair (Cohen's Kappa = 0.353, p < 0.0001), indicating that the simplified score is best suited as a pragmatic bedside risk-stratification tool rather than a direct substitute for the full model. Women were stratified into low (0-10 points), medium (11-21), and high-risk (22-36) groups corresponding to increasing predicted probabilities of low birth weight (3.2%-96.3%).ConclusionUltrasound-based fetal weight estimation using the Hadlock-III formula indicated acceptable accuracy and strong correlation with actual birth weight. We developed and internally validated prediction model for low birth weight with excellent discrimination, good calibration, and predictive value beyond estimated fetal weight alone. A risk-score tool was created to facilitate rapid bedside risk stratification. However, given the single-center nature of the study and the absence of external validation, further multicenter validation is required before broader clinical implementation. FAU - Mekonin, Amsalu Worku AU - Mekonin AW AD - Department of Obstetrics and Gynecology, College of Medicine and Health Sciences Bahir Dar University, Bahir Dar, Ethiopia. FAU - Debas, Sintayehu AU - Debas S AD - Department of Obstetrics and Gynecology, College of Medicine and Health Sciences Bahir Dar University, Bahir Dar, Ethiopia. FAU - Fenta, Haile Mekonnen AU - Fenta HM AD - Department of Statistics, College of Natural Sciences Bahir Dar University, Bahir Dar, Ethiopia. FAU - Wubie, Yihun Miskir AU - Wubie YM AD - Departments of Adult Nursing, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. RINGGOLD: 128158 FAU - Zegeye, Asres AU - Zegeye A AD - Sirinka Agricultural Research Center, Amhara Agricultural Research Institute, Bahir Dar, Ethiopia. FAU - Anteneh, Zelalem Alamrew AU - Anteneh ZA AUID- ORCID: 0000-0003-4879-675X AD - Departments of Epidemiology and Biostatistics, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. RINGGOLD: 128158 LA - eng PT - Journal Article DEP - 20260713 PL - England TA - Sci Prog JT - Science progress JID - 0411361 SB - IM MH - Humans MH - Female MH - *Fetal Weight MH - Retrospective Studies MH - *Ultrasonography, Prenatal/methods MH - Pregnancy MH - *Infant, Low Birth Weight MH - Ethiopia MH - Adult MH - Infant, Newborn MH - Gestational Age MH - Prediction Algorithms MH - Birth Weight PMC - PMC13457155 OTO - NOTNLM OT - accuracy OT - estimated fetal weight OT - low birth weight OT - risk prediction OT - ultrasound COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/13 12:35 MHDA- 2026/07/13 12:36 PMCR- 2026/07/13 CRDT- 2026/07/13 09:43 PHST- 2026/07/13 12:36 [medline] PHST- 2026/07/13 12:35 [pubmed] PHST- 2026/07/13 09:43 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - 10.1177_00368504261468514 [pii] AID - 10.1177/00368504261468514 [doi] PST - ppublish SO - Sci Prog. 2026 Jul-Sep;109(3):368504261468514. doi: 10.1177/00368504261468514. Epub 2026 Jul 13. PMID- 42438849 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2733-7545 (Electronic) IS - 2733-7545 (Linking) VI - 30 IP - 2 DP - 2026 Jun TI - Screening for insulin resistance in children with abdominal obesity: sex-specific performance of TyG index, FGIR, and VAI. PG - 90-98 LID - 10.20463/pan.2026.0026 [doi] AB - PURPOSE: This study aimed to compare the diagnostic performance of the triglyceride-glucose index (TyG), fasting glucose-to-insulin ratio (FGIR), and visceral adiposity index (VAI) for detecting insulin resistance (IR) and to establish sex-specific IR cutoffs in Korean schoolchildren with abdominal obesity. METHODS: This cross-sectional study included 728 fourth- to sixth-grade students (398 boys and 330 girls; mean age, 11.5 +/- 1.1 years) from P City, Gyeonggi-do (June 2018-August 2019). Abdominal obesity was defined as waist circumference and waist-to-height ratio >/= 90th percentile (high-risk subgroup, n = 192). IR was classified using sex-specific homeostasis model assessment of insulin resistance cutoffs (boys >/= 3.54, girls >/= 3.69). Receiver operating characteristic analysis with the Youden index was performed to compare TyG index, FGIR, and VAI in the high-risk subgroup. RESULTS: FGIR demonstrated superior performance in both sexes. The area under the curve (AUC) was 0.939 (95% confidence interval [CI], 0.903-0.976) for boys and 0.894 (95% CI, 0.835-0.954) for girls. Corresponding cutoff values were 8.435 and 7.473, with sensitivities of 94.9% and 91.2% and specificities of 79.6% and 81.2%, respectively. TyG and VAI exhibited lower AUCs (0.726‒0.768 and 0.679‒0.740, respectively). High-risk abdominal obesity was strongly associated with IR (adjusted odds ratio 6.175, 95% CI, 3.958-9.633). CONCLUSION: Among Korean school-aged children with abdominal obesity, FGIR outperformed TyG and VAI as surrogate markers of IR. Accounting for pubertal insulin dynamics with sex-specific cutoff values supports the use of FGIR as a practical, low-cost tool for early screening and intervention in high-risk groups. FAU - Jin, Youngyun AU - Jin Y AD - Department of Sport Science, Sungkyunkwan University, Suwon, Republic of Korea. FAU - Kim, Donghyun AU - Kim D AD - Department of Sport and Health Science, National Hanbat University, Daejeon, Republic of Korea. hyun0714@hanbat.ac.kr. AD - Department of Big Data and Healthcare Convergence, National Hanbat University, Daejeon, Republic of Korea. hyun0714@hanbat.ac.kr. LA - eng PT - Journal Article DEP - 20260630 PL - Korea (South) TA - Phys Act Nutr JT - Physical activity and nutrition JID - 101770644 PMC - PMC13358607 OTO - NOTNLM OT - Abdominal Obesity OT - Fasting Glucose-to-Insulin Ratio OT - Insulin Resistance OT - School-aged children OT - Triglyceride-Glucose Index COIS- No potential conflict of interest relevant to this article was reported. EDAT- 2026/07/13 06:33 MHDA- 2026/07/13 06:34 PMCR- 2026/06/01 CRDT- 2026/07/13 03:48 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/07/13 06:34 [medline] PHST- 2026/07/13 06:33 [pubmed] PHST- 2026/07/13 03:48 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - pan.2026.0026 [pii] AID - pan-2026-0026 [pii] AID - 10.20463/pan.2026.0026 [doi] PST - ppublish SO - Phys Act Nutr. 2026 Jun;30(2):90-98. doi: 10.20463/pan.2026.0026. Epub 2026 Jun 30. PMID- 42438389 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260806 IS - 1938-744X (Electronic) IS - 1935-7893 (Linking) VI - 20 DP - 2026 Jul 13 TI - Short-term Mental Health Changes Seen in Mothers and Play-age Children after the 2023 Turkiye-Syria Earthquakes. PG - e130 LID - 10.1017/dmp.2026.10404 [doi] AB - OBJECTIVE: To evaluate the mental health of play-age children affected by the 2023 Turkiye-Syria earthquakes and their mothers, using single-item scales. METHODS: Four hundred earthquake survivor mother-child dyads were included. The mental health of mothers and children was assessed using single-item screening tools, the Self-Reported Mother Mental Health (SRMH) and the Mother-Reported Child Mental Health (MRCMH). RESULTS: The prevalence of negative mental health increased from 10% to 52% in play-age children and from 13% to 70% in their mothers after the earthquakes. For post-earthquake negative SRMH, associated factors included limited access to safe water (AOR = 2.52, 95% CI: 1.10-5.75, P = 0.029), good perception of security services (AOR = 0.30, 95% CI: 0.12-0.73, P = 0.008), and post-earthquake negative MRCMH (AOR = 8.65, 95% CI: 4.70-15.91, P < 0.001). For post-earthquake negative MRCMH, associated factors were out-of-house sheltering (AOR = 3.13, 95% CI: 1.72-5.69, P < 0.001), good perception of nutritional services (AOR = 0.46, 95% CI: 0.22-0.96, P = 0.039), pre-earthquake negative MRCMH (AOR = 4.68, 95% CI: 1.87-11.73, P = 0.001), and post-earthquake negative SRMH (AOR = 11.35, 95% CI: 5.92-21.76, P < 0.001). CONCLUSION: Post-earthquake mental health outcomes were most consistently predicted by limited basic resources (water and nutrition services), not good service quality, and pre-existing or co-occurring negative mental health. FAU - Tezol, Ozlem AU - Tezol O AUID- ORCID: 0000-0001-9994-7832 AD - Pediatrics Department, https://ror.org/04nqdwb39School of Medicine, Mersin University, Mersin, Turkiye. FAU - Yalcin, Siddika Songul AU - Yalcin SS AD - Social Pediatrics Department, https://ror.org/04kwvgz42School of Medicine, Hacettepe University, Ankara, Turkiye. FAU - Gunes, Bulent AU - Gunes B AD - Pediatrics Department, https://ror.org/057qfs197School of Medicine, Harran University, Sanliurfa, Turkiye. FAU - Almis, Habip AU - Almis H AD - Social Pediatrics Department, https://ror.org/030z8x523Sincan Training and Research Hospital, Health Sciences University, Ankara, Turkiye. FAU - Barutcu, Adnan AU - Barutcu A AUID- ORCID: 0000-0001-8930-1122 AD - Social Pediatrics Department, https://ror.org/05wxkj555School of Medicine, Cukurova University, Adana, Turkiye. FAU - Erat Nergiz, Meryem AU - Erat Nergiz M AD - Pediatrics Department, School of Medicine, Ankara Yildirim Beyazit University, Ankara Yenimahalle Education and Research Hospital, Ankara, Turkiye. FAU - Orun, Emel AU - Orun E AUID- ORCID: 0000-0002-7596-5603 AD - Social Pediatrics Department, https://ror.org/01nk6sj42Ankara Etlik City Hospital, Health Sciences University, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260713 PL - United States TA - Disaster Med Public Health Prep JT - Disaster medicine and public health preparedness JID - 101297401 SB - IM MH - Humans MH - *Earthquakes/statistics & numerical data MH - Female MH - *Mothers/psychology/statistics & numerical data MH - *Mental Health/statistics & numerical data MH - Child MH - Male MH - Adult MH - Surveys and Questionnaires MH - Child, Preschool MH - Survivors/psychology/statistics & numerical data MH - Psychometrics/instrumentation/methods OTO - NOTNLM OT - Earthquake OT - mental health OT - play-age children EDAT- 2026/07/13 06:32 MHDA- 2026/07/13 06:33 CRDT- 2026/07/13 03:22 PHST- 2026/07/13 06:33 [medline] PHST- 2026/07/13 06:32 [pubmed] PHST- 2026/07/13 03:22 [entrez] AID - S1935789326104042 [pii] AID - 10.1017/dmp.2026.10404 [doi] PST - epublish SO - Disaster Med Public Health Prep. 2026 Jul 13;20:e130. doi: 10.1017/dmp.2026.10404. PMID- 42438229 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260922 IS - 1365-2834 (Electronic) IS - 0966-0429 (Print) IS - 0966-0429 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Quantitative Threshold Analysis: Assessing Breastfeeding's Protective Impact on Bronchopulmonary Dysplasia in Preterm Infants. PG - e5560949 LID - 10.1155/jonm/5560949 [doi] LID - 5560949 AB - OBJECTIVE: This study aims to thoroughly investigate the protective effects of various breastfeeding rates on bronchopulmonary dysplasia (BPD), clarify the relationship between them, and further determine the minimum protective threshold. METHODS: This prospective study enrolled 276 preterm infants who were born in the obstetrics department of a tertiary Grade A hospital in Zhejiang, China, and were directly admitted to the NICU. RESULTS: This study involved 276 infants, categorized into three breastfeeding groups based on proportion: low (100 infants, 36.2%), medium (98 infants, 35.5%), and high (78 infants, 28.3%). Notably, the incidence of BPD in the high-proportion breastfeeding group (19.5%) was significantly lower than that in the medium-proportion group (44.5%) and the low-proportion group (55%) (p < 0.05); however, there was no statistically significant difference in the incidence of BPD between the medium-proportion group and the low-proportion group (p > 0.05). Exploratory nonlinear analyses suggested a possible candidate inflection point around 0.31, above which the inverse association between breastfeeding proportion and BPD appeared stronger. CONCLUSION: Breastfeeding plays a crucial role in protecting premature infants from BPD. However, this protective effect does not increase linearly but becomes significant only when the breastfeeding rate reaches 31%. However, this threshold-related finding should be interpreted cautiously and requires validation in larger studies with more comprehensive confounder adjustment. CI - Copyright (c) 2026 Mengqing Pan et al. Journal of Nursing Management published by John Wiley & Sons Ltd. FAU - Pan, Mengqing AU - Pan M AUID- ORCID: 0009-0008-1593-2552 AD - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. AD - School of Nursing, Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. FAU - Chen, Yijia AU - Chen Y AUID- ORCID: 0009-0003-7139-8140 AD - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. AD - School of Nursing, Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. FAU - Lu, Xiaoyu AU - Lu X AUID- ORCID: 0009-0007-2557-5862 AD - School of Nursing, Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. FAU - Liu, Chuntian AU - Liu C AUID- ORCID: 0009-0002-5623-2671 AD - School of Nursing, Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. FAU - Hu, Xiaojing AU - Hu X AUID- ORCID: 0000-0003-0537-7475 AD - Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China, fudan.edu.cn. FAU - Chen, Xiaochun AU - Chen X AUID- ORCID: 0000-0003-3385-7230 AD - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. LA - eng GR - Y2023049/Wenzhou Municipal Science and Technology Bureau/ PT - Journal Article PL - England TA - J Nurs Manag JT - Journal of nursing management JID - 9306050 SB - IM EIN - J Nurs Manag. 2026;2026(1):e9851543. doi: 10.1155/jonm/9851543. PMID: 42754966 MH - Humans MH - *Breast Feeding/statistics & numerical data/methods MH - *Bronchopulmonary Dysplasia/prevention & control/epidemiology MH - Infant, Newborn MH - Female MH - Prospective Studies MH - *Infant, Premature MH - China/epidemiology MH - Male MH - Incidence MH - Intensive Care Units, Neonatal/organization & administration/statistics & numerical data PMC - PMC13358207 OTO - NOTNLM OT - breastfeeding OT - bronchopulmonary dysplasia OT - preterm infants OT - protective OT - threshold analysis COIS- The authors declare no conflicts of interest. EDAT- 2026/07/13 06:33 MHDA- 2026/07/13 06:34 PMCR- 2026/07/12 CRDT- 2026/07/13 01:53 PHST- 2026/05/01 00:00 [revised] PHST- 2025/05/21 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/07/13 06:34 [medline] PHST- 2026/07/13 06:33 [pubmed] PHST- 2026/07/13 01:53 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - JONM5560949 [pii] AID - 10.1155/jonm/5560949 [doi] PST - ppublish SO - J Nurs Manag. 2026;2026(1):e5560949. doi: 10.1155/jonm/5560949. PMID- 42438127 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 96 IP - 8 DP - 2026 Aug TI - Enhancing Motor Competence in Rhythmic Gymnastics: Effects of the Overlapping Waves Strategy in School-Based Physical Education. PG - e70195 LID - 10.1111/josh.70195 [doi] LID - e70195 AB - BACKGROUND: Rhythmic gymnastics offers a context for motor development. This study examined the association between the Overlapping Waves Strategy and traditional instruction in fundamental club skills. METHODS: A cluster-allocated quasi-experimental design (16 sessions) was implemented among 64 fifth-grade female students. Participants received Overlapping Waves Strategy (n = 32) or conventional instruction (n = 32). Four skills were assessed by certified judges. RESULTS: Two-way mixed ANOVA revealed significant group x time interactions (all p < 0.001). The experimental group exhibited greater pre-post performance gains than the control group. Implications for School Health Policy, Practice, and Equity: The strategy provides a structured pedagogical framework for physical education, suggesting potential feasibility, though limited by the specific single-setting and demographic parameters, and policy recommendations remain premature without broader replication. CONCLUSION: Preliminary findings indicate greater short-term execution of club skills in the experimental classroom. Classroom-level confounding cannot be excluded. Replication in cluster-randomized designs with retention measures is required. CI - (c) 2026 American School Health Association. FAU - Hamza, Ghofran Basheer AU - Hamza GB AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Sherkhan, Lena Ali AU - Sherkhan LA AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Ghouili, Hatem AU - Ghouili H AD - Research Unit "Sport Sciences, Health and Movement," High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. FAU - Yahya, Suhair Raad AU - Yahya SR AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Muntean, Raul Ioan AU - Muntean RI AUID- ORCID: 0000-0003-4615-6687 AD - Department of Physical Education and Sport, University "1 Decembrie 1918" of Alba Iulia, Alba Iulia, Romania. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AUID- ORCID: 0009-0005-2214-4667 AD - Physical Education of Sports Teaching Department, Faculty of Kazim Karabekir Education, Ataturk University, Erzurum, Turkiye. FAU - Stefanica, Valentina AU - Stefanica V AUID- ORCID: 0000-0003-4031-1412 AD - Department of Physical Education and Sport, Faculty of Sciences, Physical Education and Informatics, National University of Science and Technology Politehnica Bucharest, Pitesti University Center, Pitesti, Romania. FAU - Al-Selmi, Abeer Dakhil Hatem AU - Al-Selmi ADH AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Mohamood, Marwa Saadi AU - Mohamood MS AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Dhahbi, Wissem AU - Dhahbi W AUID- ORCID: 0000-0001-6221-546X AD - Research Unit "Sport Sciences, Health and Movement," High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Training Department, Qatar Police Academy, Police College, Doha, Qatar. FAU - Benezzeddine, Lamia AU - Benezzeddine L AD - High Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba, Tunisia. LA - eng PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - *Gymnastics/education/physiology MH - *Physical Education and Training/methods/organization & administration MH - Female MH - *Motor Skills/physiology MH - Child MH - *School Health Services/organization & administration MH - Schools PMC - PMC13358179 OTO - NOTNLM OT - cooperative learning OT - fundamental movement skills OT - motor competence OT - motor development OT - physical literacy OT - rhythmic gymnastics OT - school-based intervention COIS- The authors declare no conflicts of interest. EDAT- 2026/07/13 10:09 MHDA- 2026/07/13 10:10 PMCR- 2026/07/13 CRDT- 2026/07/13 00:53 PHST- 2026/05/22 00:00 [revised] PHST- 2025/09/24 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/13 10:10 [medline] PHST- 2026/07/13 10:09 [pubmed] PHST- 2026/07/13 00:53 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - JOSH70195 [pii] AID - 10.1111/josh.70195 [doi] PST - ppublish SO - J Sch Health. 2026 Aug;96(8):e70195. doi: 10.1111/josh.70195. PMID- 42437956 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261008 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Jul 12 TI - Predicting and identifying determinants of stunting among school-aged children in Ethiopia: a machine learning approach. LID - 10.1186/s41043-026-01401-y [doi] LID - 216 AB - BACKGROUND: Childhood stunting remains a major public health concern, reflecting chronic undernutrition and long-term socioeconomic disadvantage. Among school-aged children, stunting is associated with impaired physical growth, reduced cognitive development, and poorer educational outcomes. Traditional statistical approaches, such as logistic regression, have been widely used to examine factors associated with stunting; however, their ability to capture complex and nonlinear relationships is limited. Machine learning (ML) methods provide a flexible alternative for modeling such relationships. OBJECTIVE: This study aimed to model and classify stunting among school-aged children in Ethiopia using school- and household-level data, and to compare the performance of machine learning algorithms with multivariable logistic regression. METHODS: A cross-sectional analysis was conducted using secondary data from Round 5 (2016-2017) of the Young Lives study in Ethiopia. Stunting was defined as a binary outcome based on World Health Organization height-for-age Z-score criteria. Several machine learning algorithms, including Random Forest, Support Vector Machine, and Gradient Boosting Machine, were implemented. Model performance was evaluated using accuracy, sensitivity, specificity, F1-score, and area under the receiver operating characteristic curve (AUC). Variable importance measures were used to identify predictors contributing to model performance. To avoid potential circularity, anthropometric variables closely related to the outcome (e.g., child weight) were excluded from the final models. RESULTS: The Random Forest model demonstrated modestly improved performance compared with logistic regression and other machine learning methods, and its performance was evaluated using accuracy, sensitivity, specificity, AUC, and F1-score. Key predictors included school type, household wealth index, literacy-related indicators, and region of residence. Notable regional variation in stunting classification was observed, suggesting the influence of broader socioeconomic and environmental conditions. CONCLUSION: Machine learning models, particularly Random Forest, showed slightly better performance than conventional logistic regression in classifying stunting among school-aged children in Ethiopia. The identified predictors highlight the multifactorial and context-dependent nature of stunting. These findings support the use of ML approaches as complementary analytical tools for understanding patterns of child undernutrition, although their application for prediction should be interpreted within the limitations of cross-sectional data. CI - (c) 2026. The Author(s). FAU - Dugasa, Shibiru Jabessa AU - Dugasa SJ AD - Department of Statistics, Wollega University, Nekemte, Oromia, Ethiopia. shibirujabessa2021@gmail.com. FAU - Aga, Merga Abdissa AU - Aga MA AD - Department of Statistics, Salale University, Fiche, Oromia, Ethiopia. LA - eng PT - Journal Article DEP - 20260712 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - *Growth Disorders/epidemiology/etiology/diagnosis MH - Cross-Sectional Studies MH - *Machine Learning MH - Child MH - Male MH - Female MH - Predictive Learning Models MH - Random Forest MH - Classification Algorithms MH - Boosting Machine Learning Algorithms MH - Logistic Models MH - Prediction Algorithms PMC - PMC13640390 OTO - NOTNLM OT - Classification OT - Ethiopia OT - Machine learning OT - School-aged children OT - Stunting COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/13 00:32 MHDA- 2026/10/07 06:25 PMCR- 2026/07/12 CRDT- 2026/07/12 23:40 PHST- 2026/01/09 00:00 [received] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/10/07 06:25 [medline] PHST- 2026/07/13 00:32 [pubmed] PHST- 2026/07/12 23:40 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - 10.1186/s41043-026-01401-y [pii] AID - 1401 [pii] AID - 10.1186/s41043-026-01401-y [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jul 12;45(1):216. doi: 10.1186/s41043-026-01401-y. PMID- 42437943 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261008 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Jul 12 TI - Associations of starchy and non-starchy vegetable intake with depression, anxiety, stress, chronotype, and sleep quality among iranian women with overweight or obesity: a cross-sectional study. LID - 10.1186/s41043-026-01392-w [doi] LID - 217 AB - BACKGROUND: Starchy vegetables may influence psychological well-being, circadian alignment, and sleep quality through their glycemic characteristics and related metabolic effects. In contrast, non‑starchy vegetables, which differ substantially in nutrient density and bioactive compounds, may affect these outcomes through alternative physiological pathways. Despite these distinct nutritional profiles, evidence comparing their separate associations with mental health and sleep-related patterns is limited. This study explored these relationships among overweight and obese women. METHODS: In this cross-sectional study, 391 overweight and obese women aged 18-48 years were recruited using a cluster sampling strategy from community health centres. Data collection was conducted through structured face‑to‑face interviews performed by trained nutritionists. Mental health indicators (depression, anxiety, and stress) were assessed using the Persian DASS‑21, sleep quality was evaluated using the PSQI, and circadian preference was measured using the MEQ. Dietary intake was obtained through a validated 147‑item food frequency questionnaire (FFQ). Anthropometric measurements, blood samples, biochemical markers, physical activity, and demographic information were collected following standardized procedures. RESULTS: The study included 391 women, with a mean age of 38.08 +/- 8.61 years in the high non-starchy vegetable intake group and 35.31 +/- 9.59 years in the low non-starchy vegetable intake group, all classified as overweight or obese. Participants with higher non‑starchy vegetable intake exhibited significantly lower odds of depression (adjusted OR = 0.40, 95% CI = 0.20-0.79, P < 0.001) and stress (adjusted OR = 0.30, 95% CI = 0.14-0.85, P = 0.02). Higher non‑starchy vegetable consumption was also associated with improved sleep quality (adjusted OR = 0.38, 95% CI = 0.19-0.77, P = 0.007). Furthermore, increased starchy vegetable intake was inversely associated with the morning-type chronotype (adjusted OR = 0.27, 95% CI = 0.09-0.83, P = 0.02) after full adjustment. CONCLUSIONS: Higher non-starchy vegetable intake was associated with lower odds of depression, stress, and poor sleep quality, while greater starchy vegetable consumption was linked to a lower likelihood of morning-type chronotype. Increasing non-starchy vegetable intake may support psychological well-being and sleep health, though longitudinal studies are needed to confirm causality. CI - (c) 2026. The Author(s). FAU - Roumi, Zahra AU - Roumi Z AD - Department of Clinical Nutrition and Dietetics , Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Mirzababaei, Atieh AU - Mirzababaei A AD - Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. ati_babaee@yahoo.com. AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. ati_babaee@yahoo.com. FAU - Abaj, Faezeh AU - Abaj F AD - Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia. FAU - Clark, Cain C T AU - Clark CCT AD - Centre for Intelligent Healthcare, CV1 5FB, Coventry, U.K. FAU - Jadidi, Paria AU - Jadidi P AD - Department of Nutrition, SR.C, Islamic Azad University, Tehran, Iran. FAU - Rasekhmagham, Reyhaneh AU - Rasekhmagham R AD - Department of Nutrition, SR.C, Islamic Azad University, Tehran, Iran. FAU - Mirzaei, Khadijeh AU - Mirzaei K AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. LA - eng GR - 97-03-161-41155/Tehran University of Medical Sciences and Health Services/ PT - Journal Article DEP - 20260712 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - Iran/epidemiology MH - Middle Aged MH - *Depression/epidemiology MH - Chronotype MH - *Obesity/psychology MH - *Sleep Quality MH - *Vegetables MH - *Stress, Psychological/epidemiology MH - *Overweight/psychology MH - *Anxiety/epidemiology MH - Adolescent MH - Young Adult MH - *Diet MH - Sleep PMC - PMC13640202 OTO - NOTNLM OT - Circadian rhythm OT - Female population OT - Mental health OT - Obesity OT - Sleep quality OT - Starchy/non-starchy vegetables COIS- Declarations. Ethics approval and consent to participate: The authors and the Ethics Committee of Tehran University of Medical Sciences (IR.TUMS.VCR.REC.1398.692) have received approval for the method and protocol of the current study. Additionally, written informed consent has been obtained from all participants. Consent for publication: All authors collaborated in editing this article, and the final version was approved for submission. Furthermore, they actively participated in writing the manuscript and giving their approval to the final draft. Competing interests: The authors declare no competing interests. EDAT- 2026/07/13 04:09 MHDA- 2026/10/07 06:25 PMCR- 2026/07/12 CRDT- 2026/07/12 23:39 PHST- 2025/12/04 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/10/07 06:25 [medline] PHST- 2026/07/13 04:09 [pubmed] PHST- 2026/07/12 23:39 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - 10.1186/s41043-026-01392-w [pii] AID - 1392 [pii] AID - 10.1186/s41043-026-01392-w [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jul 12;45(1):217. doi: 10.1186/s41043-026-01392-w. PMID- 42437837 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261008 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 93 IP - 9 DP - 2026 Sep TI - Gut Microbiome in Neonatal Necrotizing Enterocolitis - A Comprehensive Review of Evidence. PG - 968-975 LID - 10.1007/s12098-026-06300-y [doi] AB - Necrotizing enterocolitis (NEC) is one of the most catastrophic gastrointestinal emergency occurring predominantly in preterm neonates. It contributes to substantial neonatal morbidity and mortality. Disturbances in the intestinal microbiome are crucial to disease pathogenesis. In preterm infants, an immature intestinal barrier, dysregulated immune responses, and environmental exposures altogether predispose to alteration in microbial colonization and intestinal inflammation. This review was done to present the current evidence on gut microbiome alterations associated with NEC in preterm infants. A systematic search of the MEDLINE and EMBASE databases was performed using search strategy related to prematurity, intestinal microbiota, and necrotizing enterocolitis. A total of 42 studies assessing microbial composition, microbial progression, or microbial functional patterns in relation to NEC were included. Across the included studies, NEC was commonly preceded by reduced microbial diversity, delayed maturation of anerobic communities, and expansion of Proteobacteria, particularly Enterobacteriaceae family such as Klebsiella and Escherichia. Longitudinal studies further showed that these microbial changes may become evident days to weeks before clinical disease, suggesting a potential window for early risk identification. Functional analyses also showed alterations in microbial metabolic pathways, including short-chain fatty acids, tricarboxylic acid intermediates, volatile compounds, and viral signatures that may lead to epithelial injury and inflammatory signaling. Clinical and environmental factors including antibiotic exposure, mode of delivery, feeding practices, and NICU microbial ecosystem are important determinants of neonatal gut microbiome development. Thus, the current evidence supports a reproducible pattern of intestinal dysbiosis preceding NEC. Better understanding of microbiome dynamics may aid early risk stratification and support microbiome-targeted preventive strategies in vulnerable preterm populations. CI - (c) 2026. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - Devi, Usha AU - Devi U AD - Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India. FAU - Ramadass, Balamurugan AU - Ramadass B AD - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhubaneswar; Center of Excellence for Clinical Microbiome Research (CCMR), All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India. FAU - Pullattayil, Abdul Kareem AU - Pullattayil AK AD - Bracken Health Sciences Library, Queen's University, Kingston, ON, Canada. FAU - Vishnu Bhat, Ballambattu AU - Vishnu Bhat B AUID- ORCID: 0000-0002-8856-7348 AD - Adviser-Medical Research and Publications, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation-DU, Puducherry, India. drvishnubhat@yahoo.com. LA - eng PT - Journal Article PT - Review DEP - 20260713 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 SB - IM MH - Humans MH - *Enterocolitis, Necrotizing/microbiology MH - Infant, Newborn MH - *Gastrointestinal Microbiome/physiology MH - Infant, Premature OTO - NOTNLM OT - Dysbiosis OT - Gut microbiome OT - Metabolomics OT - Metagenomics OT - Necrotizing enterocolitis OT - Preterm infant COIS- Declarations. Conflict of Interest: None. EDAT- 2026/07/13 00:32 MHDA- 2026/08/28 11:46 CRDT- 2026/07/12 23:24 PHST- 2026/04/10 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/07/13 00:32 [pubmed] PHST- 2026/07/12 23:24 [entrez] AID - 10.1007/s12098-026-06300-y [pii] AID - 10.1007/s12098-026-06300-y [doi] PST - ppublish SO - Indian J Pediatr. 2026 Sep;93(9):968-975. doi: 10.1007/s12098-026-06300-y. Epub 2026 Jul 13. PMID- 42437539 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260926 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 204 DP - 2026 Nov TI - Assessment of treatment response in recurrent medulloblastoma using craniospinal MRI. PG - 113056 LID - S0720-048X(26)00404-3 [pii] LID - 10.1016/j.ejrad.2026.113056 [doi] AB - BACKGROUND: To evaluate whether quantitative craniospinal MRI assessment of baseline tumor burden provides prognostic value in patients with recurrent, previously irradiated medulloblastoma undergoing MEMMAT (Metronomic Antiangiogenic) therapy. METHODS: We analyzed craniospinal MRI of 40 patients with recurrent, previously irradiated medulloblastoma enrolled in the MEMMAT trial (April 1, 2014, and March 31, 2021). Ependymal, leptomeningeal, and local relapse lesions were retrospectively manually segmented on T1-contrast-enhanced (T1CE) and diffusion-weighted imaging (DWI) at baseline and follow-up (best response). Lesion count and volume were quantified. Bland-Altman analyses and intraclass correlation coefficients (ICC) assessed inter-sequence agreement., logistic regression evaluated associations between baseline tumor burden and progressive disease. RESULTS: Patients achieving Complete Response (n = 6/40) showed mean monthly decreases of - 12.7% in T1CE lesion count and - 12.9% in volume. Partial Response patients (n = 9/40) showed similar declines (-10.3% and - 13.0%). Stable Disease patients (n = 5/40) demonstrated minimal decreases (-0.8% and - 2.3%). Progressive Disease patients (n = 16/40) showed increases of 33.7% in lesion count and 56.2% in volume. Logistic regression indicated trends toward higher baseline tumor burden predicting PD (volume OR 1.18, p = 0.08; lesion count OR 1.05, p = 0.075). Agreement between T1CE and DWI was limited (ICC 0.35 for lesion count, 0.47 for volume), with 23% of patients misclassified using either modality alone. Survival analyses demonstrated significantly shorter overall survival in patients with baseline lesion volumes >/= 5.5 ml (log-rank p = 0.003), while a similar association for progression-free survival did not reach statistical significance (p = 0.053). CONCLUSIONS: Combined intracranial and intraspinal T1CE and intracranial DWI assessment improves response evaluation. Exploratory analyses suggested that higher baseline tumor burden may be associated with progression, although the observed associations were of borderline statistical significance and require validation in larger cohorts. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Hennenberg, Juliane AU - Hennenberg J AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Hofer, Leo AU - Hofer L AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Nemeth, Bence AU - Nemeth B AD - Faculty of Information Technology and Bionics, Pazmany Peter Catholic University Budapest, Budapest, Hungary; University Hospital Zurich, Department of Neuroradiology, Zurich, Switzerland. FAU - Vollbrecht, Carolin AU - Vollbrecht C AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Tukora, Greta AU - Tukora G AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Mayr, Lisa AU - Mayr L AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Bolotin, Jewgeni AU - Bolotin J AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany. FAU - Zelei, Regina AU - Zelei R AD - Faculty of Information Technology and Bionics, Pazmany Peter Catholic University Budapest, Budapest, Hungary. FAU - Racz, Adrienn AU - Racz A AD - Faculty of Information Technology and Bionics, Pazmany Peter Catholic University Budapest, Budapest, Hungary. FAU - Barkhof, Frederik AU - Barkhof F AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Queen Square Institute of Neurology, University College London, London, United Kingdom; Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands. FAU - Slavc, Irene AU - Slavc I AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Sabel, Magnus AU - Sabel M AD - Childhood Cancer Centre, Queen Silvia Childrens Hospital, Sahlgrenska University Hospital, and Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Lassaletta, Alvaro AU - Lassaletta A AD - Pediatric Neuro-Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Sterba, Jaroslav AU - Sterba J AD - Pediatric Oncology Department, Brno University Hospital, Brno, Czech Republic. FAU - Leblond, Pierre AU - Leblond P AD - Pediatric Oncology Unit, Oscar Lambret Cancer Center, Lille, France; Centre Leon Berard, Institut d'Hematologie et d'Oncologie Pediatrique, Lyon, France. FAU - Nyson, Karsten AU - Nyson K AD - Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. FAU - Torsvik, Ingrid AU - Torsvik I AD - Department of Paediatric and Adolecent Medicine, Haukeland University Hospital, Bergen, Norway. FAU - Chi, Susan N AU - Chi SN AD - Pediatric Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, United States. FAU - Schmook, Maria AU - Schmook M AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Furtner, Julia AU - Furtner J AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; Research Center for Medical Image Analysis and Artificial Intelligence (MIAAI), Faculty of Medicine and Dentistry, Danube Private University, Krems-Stein, Austria. FAU - Mayerhoefer, Marius E AU - Mayerhoefer ME AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; Department of Radiology, NYU Grossman, United States. FAU - Kasprian, Gregor AU - Kasprian G AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Azizi, Amedeo AU - Azizi A AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Gojo, Johannes AU - Gojo J AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Peyrl, Andreas AU - Peyrl A AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Haider, Lukas AU - Haider L AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Queen Square Institute of Neurology, University College London, London, United Kingdom. Electronic address: lukas.haider@meduniwien.ac.at. LA - eng PT - Journal Article DEP - 20260709 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 RN - 0 (Angiogenesis Inhibitors) RN - 0 (Contrast Media) SB - IM MH - Humans MH - *Medulloblastoma/diagnostic imaging/drug therapy/pathology MH - Female MH - Male MH - *Neoplasm Recurrence, Local/diagnostic imaging MH - Child MH - *Magnetic Resonance Imaging/methods MH - Treatment Outcome MH - Adolescent MH - Child, Preschool MH - *Cerebellar Neoplasms/diagnostic imaging/drug therapy MH - Retrospective Studies MH - Tumor Burden MH - Angiogenesis Inhibitors/therapeutic use MH - Prognosis MH - Contrast Media OTO - NOTNLM OT - Medulloblastoma OT - Metronomic antiangiogenic therapy OT - Treatment response COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/12 18:31 MHDA- 2026/09/26 05:34 CRDT- 2026/07/12 17:59 PHST- 2026/05/01 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/07/12 18:31 [pubmed] PHST- 2026/07/12 17:59 [entrez] AID - S0720-048X(26)00404-3 [pii] AID - 10.1016/j.ejrad.2026.113056 [doi] PST - ppublish SO - Eur J Radiol. 2026 Nov;204:113056. doi: 10.1016/j.ejrad.2026.113056. Epub 2026 Jul 9. PMID- 42437494 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260909 IS - 1552-8456 (Electronic) IS - 0193-9459 (Linking) VI - 48 IP - 9 DP - 2026 Sep TI - Effects of Low, Moderate, and High Intensity Exercise on Functional Impairment and ADHD Symptoms: A Randomized Pilot Study. PG - 980-987 LID - 10.1177/01939459261458869 [doi] AB - BACKGROUND: Exercise improves cognitive functions impaired in attention deficit/hyperactivity disorder (ADHD); however, most research involves children or animal models. Effects on adult ADHD symptoms and optimal exercise intensity remain unclear. Moderate and high intensity cycling show benefits. PURPOSE: We evaluated the feasibility of an exercise intervention and compared 3 levels of exercise intensity in college students with ADHD symptoms. METHODS: In a randomized controlled trial, 33 participants were assigned to low, moderate, or high intensity exercise. All groups cycled for 20 minutes. The low and moderate intensity groups cycled at low or moderate intensity, respectively. The high intensity group alternated 20-second maximal effort bursts with 120 seconds of low-intensity cycling. The exercise occurred over 1 week. Outcomes were evaluated before and after the intervention. RESULTS: There was a decrease in functional impairment (F = 7.98, P = .009, partial eta(2) = 0.222) and symptom severity (F = 13.43, P = .001, partial eta(2) = 0.324). There was no difference between groups. Inattentive symptoms responded to low intensity (t = 2.62, P = .015, d = 0.874) and moderate intensity exercise (t = 2.61, P = .013, d = 0.786). Impulsive symptoms benefited from low (t = 4.06, P = .002, d = 1.35) and moderate intensity exercise (t = 1.99, P = .037, d = 0.600). Hyperactive symptoms were reduced in the moderate intensity group (t = 2.6, P = .013, d = 0.783). CONCLUSION: Feasibility was demonstrated. Moderate intensity exercise appears to be the most universally effective intensity for reducing ADHD symptoms. STUDY REGISTRATION: ClinicalTrials.gov, NCT06753253. FAU - Edmondson, Meghan E AU - Edmondson ME AUID- ORCID: 0009-0004-0850-2555 AD - College of Nursing, Kent State University, OH, USA. AD - Brain Health Research Institute, Kent State University, OH, USA. AD - Healthy Communities Research Institute, Kent State University, OH, USA. FAU - Ridgel, Angela L AU - Ridgel AL AUID- ORCID: 0000-0001-8517-8710 AD - Brain Health Research Institute, Kent State University, OH, USA. AD - Program of Exercise Science and Exercise Physiology, School of Health Sciences, Kent State University, OH, USA. LA - eng SI - ClinicalTrials.gov/NCT06753253 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260712 PL - United States TA - West J Nurs Res JT - Western journal of nursing research JID - 7905435 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/therapy/psychology MH - Pilot Projects MH - Female MH - Male MH - *Exercise/physiology/psychology MH - *Exercise Therapy/methods/standards MH - Adult OTO - NOTNLM OT - ADHD symptoms OT - attention deficit/hyperactivity disorder OT - exercise OT - intervention OT - physical activity COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/12 22:37 MHDA- 2026/08/12 06:05 CRDT- 2026/07/12 13:02 PHST- 2026/08/12 06:05 [medline] PHST- 2026/07/12 22:37 [pubmed] PHST- 2026/07/12 13:02 [entrez] AID - 10.1177/01939459261458869 [doi] PST - ppublish SO - West J Nurs Res. 2026 Sep;48(9):980-987. doi: 10.1177/01939459261458869. Epub 2026 Jul 12. PMID- 42436557 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260911 IS - 1757-2215 (Electronic) IS - 1757-2215 (Linking) VI - 19 IP - 1 DP - 2026 Jul 11 TI - Psychological distress and quality of life in women with infertility due to polycystic ovarian syndrome versus unexplained infertility: a cross-sectional study with phenotype-based analysis. LID - 10.1186/s13048-026-02186-8 [doi] LID - 268 AB - BACKGROUND: Infertility is associated with significant psychological distress and impaired quality of life (QoL) in women. Polycystic Ovarian Syndrome (PCOS), a common cause of infertility, is frequently associated with metabolic and psychological symptoms. However, limited evidence directly compares psychological symptom burden and QoL between women with PCOS-related infertility and unexplained infertility, including across PCOS phenotypes. METHODS: This cross-sectional observational study included 240 women aged 18-40 years with infertility due to PCOS or unexplained causes, conducted at a tertiary care center between October 2019 and March 2021. PCOS was diagnosed using revised Rotterdam criteria, and unexplained infertility was defined after exclusion of known causes. Psychological outcomes were assessed using validated screening instruments (PHQ-9, BDI, BAI, and GAD-7), representing symptom severity rather than clinical psychiatric diagnoses. QoL was assessed using WHOQOL-BREF. Statistical analysis included group comparisons using appropriate parametric and non-parametric tests, with p < 0.05 considered statistically significant. RESULTS: Women with PCOS demonstrated significantly higher screening-based depressive symptom burden (60% vs. 14%, p < 0.001) and anxiety symptom burden (63% vs. 21%, p < 0.001) compared to women with unexplained infertility. QoL scores were significantly lower in the PCOS group (66.8% vs. 85.1%, p < 0.001), particularly in psychological and social domains. Among PCOS phenotypes, hyperandrogenic phenotypes (B and C) showed relatively higher psychological symptom burden and lower QoL scores compared to other phenotypes. The PCOS group also demonstrated higher BMI and androgen levels. CONCLUSION: Infertility associated with PCOS is linked to higher screening-based psychological symptom burden and reduced quality of life compared to unexplained infertility. Hyperandrogenic PCOS phenotypes appear to be more affected. These findings support the integration of routine psychological screening and multidisciplinary support into infertility care for women with PCOS. CI - (c) 2026. The Author(s). FAU - Kataria, Kamna AU - Kataria K AD - Department of Obstetrics & Gynecology, VMMC & Safdarjung Hospital, New Delhi, 110029, India. FAU - Kapoor, Garima AU - Kapoor G AD - Department of Obstetrics & Gynecology, VMMC & Safdarjung Hospital, New Delhi, 110029, India. garimak79@yahoo.co.in. FAU - Saha, Rahul AU - Saha R AD - Department of Psychiatry at VMMC & Safdarjung Hospital, New Delhi, 110029, India. FAU - Lachyan, Abhishek AU - Lachyan A AD - Department of Obstetrics & Gynecology, VMMC & Safdarjung Hospital, New Delhi, 110029, India. LA - eng PT - Journal Article PT - Observational Study DEP - 20260711 PL - England TA - J Ovarian Res JT - Journal of ovarian research JID - 101474849 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/complications/psychology MH - *Quality of Life/psychology MH - Cross-Sectional Studies MH - Adult MH - *Infertility, Female/psychology/etiology MH - Phenotype MH - Young Adult MH - Adolescent MH - *Psychological Distress PMC - PMC13508219 OTO - NOTNLM OT - Anxiety OT - Depression OT - Infertility OT - PCOS phenotypes OT - Polycystic ovarian syndrome OT - Quality of life COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was obtained from the Institutional Ethics Committee of VMMC & Safdarjung Hospital (IEC approval no. IEC/VMMC/SJH/THESIS/2019-10/89; approved on 30 October 2019). The study was conducted in accordance with the principles of the Declaration of Helsinki (2013 revision). Written informed consent was obtained from all participants prior to their inclusion in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:56 MHDA- 2026/08/27 05:35 PMCR- 2026/07/11 CRDT- 2026/07/11 23:38 PHST- 2026/02/24 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/07/12 00:56 [pubmed] PHST- 2026/07/11 23:38 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s13048-026-02186-8 [pii] AID - 2186 [pii] AID - 10.1186/s13048-026-02186-8 [doi] PST - epublish SO - J Ovarian Res. 2026 Jul 11;19(1):268. doi: 10.1186/s13048-026-02186-8. PMID- 42436527 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 52 IP - 1 DP - 2026 Jul 11 TI - Occurrence of diarrhea in pediatric bronchopneumonia patients: relevance to nursing management. LID - 10.1186/s13052-026-02301-x [doi] LID - 149 AB - BACKGROUND: Diarrhea represents a frequent complication in pediatric patients with bronchopneumonia. This study was designed to identify independent risk factors for diarrheal complications and to propose evidence-informed nursing interventions. METHODS: A retrospective cohort study was conducted among 280 hospitalized children with bronchopneumonia. Demographic, anthropometric, laboratory, and treatment-related data were extracted from electronic medical records. Multicollinearity was assessed by variance inflation factor (VIF), and independent risk factors were identified through binary logistic regression with model fit evaluated by the Hosmer-Lemeshow test. RESULTS: The incidence of diarrhea was 23.57%. Eight independent risk factors were identified: antibiotic duration >/= 7 days (OR = 3.006), beta-lactamase inhibitor combination use (OR = 2.916), combined antibiotic use (OR = 2.401), mixed pulmonary infection (OR = 2.105), age < 5 years (OR = 2.048), weight-for-height/length z-score < - 2 (OR = 1.982), serum albumin < 35 g/L (OR = 1.896), and C-reactive protein >/= 20 mg/L (OR = 1.845). Probiotic administration was an independent protective factor (OR = 0.849). All VIF values were < 5, and the Hosmer-Lemeshow test indicated adequate model fit (P > 0.05). CONCLUSION: Diarrhea in children with bronchopneumonia is associated with multiple clinical and therapeutic variables, with beta-lactamase inhibitor combinations and prolonged antibiotic therapy conferring the highest risk. These findings provide a hypothesis-generating foundation for risk-stratified nursing strategies to reduce diarrheal complications. However, given the retrospective design and the inability to distinguish antibiotic-associated diarrhea from infectious diarrhea, the identified associations should be interpreted cautiously, and any derived clinical recommendations require prospective validation. CI - (c) 2026. The Author(s). FAU - Tang, Yinyan AU - Tang Y AD - Department of pediatrics, Nanjing Lishui People's Hospital, No. 86 Chongwen Road, Lishui District, Nanjing, Jiangsu Province, China. FAU - Zhang, Qian AU - Zhang Q AD - Department of pediatrics, Nanjing Lishui People's Hospital, No. 86 Chongwen Road, Lishui District, Nanjing, Jiangsu Province, China. FAU - Yu, Tingting AU - Yu T AD - Department of pediatrics, Nanjing Lishui People's Hospital, No. 86 Chongwen Road, Lishui District, Nanjing, Jiangsu Province, China. 564440307@qq.com. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - Ital J Pediatr JT - Italian journal of pediatrics JID - 101510759 RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - Retrospective Studies MH - *Diarrhea/epidemiology/nursing/etiology MH - *Bronchopneumonia/complications/drug therapy/nursing MH - Female MH - Male MH - Risk Factors MH - Child, Preschool MH - Infant MH - Incidence MH - Anti-Bacterial Agents/adverse effects MH - Child PMC - PMC13644138 OTO - NOTNLM OT - Bronchopneumonia OT - Children OT - Clinical OT - Diarrhea OT - Nursing OT - Treatment COIS- Declarations. Ethics approval and consent to participate: In this study, all methods were performed in accordance with the relevant guidelines and regulations. The study has been reviewed and approved by the ethics committee of Nanjing Lishui People's Hospital (Ethics Approval No.: 2025KY0922-02). Although written informed consent from the children's guardians was not separately obtained due to the retrospective nature of the study, the Ethics Committee has verified that: the research data are non-identifiable information generated during routine clinical diagnosis and treatment; the study results can be used to clarify the influencing factors of bronchopneumonia complicated with diarrhea in children and optimize clinical nursing protocols, ultimately providing evidence-based support for reducing the incidence of pneumonia-related complications in children and improving their prognosis. The public health value and potential benefits of the study are significantly greater than the risks, which is in line with the ethical principle of "reasonable risk-benefit ratio". Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/07/12 04:10 MHDA- 2026/10/07 05:31 PMCR- 2026/07/11 CRDT- 2026/07/11 23:37 PHST- 2026/04/04 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/10/07 05:31 [medline] PHST- 2026/07/12 04:10 [pubmed] PHST- 2026/07/11 23:37 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s13052-026-02301-x [pii] AID - 2301 [pii] AID - 10.1186/s13052-026-02301-x [doi] PST - epublish SO - Ital J Pediatr. 2026 Jul 11;52(1):149. doi: 10.1186/s13052-026-02301-x. PMID- 42436490 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1472-6963 (Electronic) IS - 1472-6963 (Linking) VI - 26 IP - 1 DP - 2026 Jul 11 TI - Assessment of maternal healthcare utilization and continuum of care among reproductive-age women in Gujarat: a cross-sectional study. LID - 10.1186/s12913-026-15063-3 [doi] LID - 1325 AB - BACKGROUND: A healthcare system's efficacy is demonstrated by safe motherhood, which is an essential aspect of women's health. Preconception, pregnancy, labor, and the postoperative phase are all included in this continuum of care. There are still gaps in maternal healthcare awareness, use, and continuity, especially during preconception and the early postnatal stages, even though India has made great strides in lowering maternal mortality through national health programs and better access to institutional deliveries and antenatal care. The purpose of this study was to evaluate Gujarati women's knowledge, availability, and use of maternal health services, with an emphasis on preconception care, prenatal care, delivery procedures, and postnatal follow-up. METHODOLOGY: The study used a descriptive cross-sectional methodology and included 318 reproductive-age women from semi-urban, urban, and rural areas using a structured pre-validated questionnaire. Both quantitative information about maternal health practices and experiences were gathered through in-person interviews and Google Forms and analyzed using descriptive statistics including frequencies and percentages in Microsoft Excel. RESULTS: Among the 318 respondents, 75.5% were aged 18-30 years and 50% resided in rural areas. Awareness regarding preconception health checkups was reported by 71.1% of women, whereas 28.9% lacked such awareness. Antenatal care utilization was high, with 87.1% attending antenatal checkups, the majority receiving tetanus toxoid immunization and iron-folic acid supplementation, and 97.3% undergoing institutional deliveries with skilled birth assistance. However, only 58.2% of women received postnatal care within 48 hours after delivery. Nutritional counseling was reported by 41% of respondents, while 55.2% received breastfeeding counseling. Significant gaps were found in preconception health information, early postnatal follow-up, and emotional support, especially among rural women. CONCLUSION: The study highlights the need to shift focus from service availability to continuity and quality of maternal care. Strengthening preconception education, ensuring timely postnatal follow-up through community health workers, expanding counseling services, and promoting family engagement are essential to improving maternal and neonatal health outcomes. CI - (c) 2026. The Author(s). FAU - Avhad, Ujwala AU - Avhad U AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Gohel, Swati AU - Gohel S AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Sompura, Parth AU - Sompura P AD - Parul Institute of Allied & Healthcare Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Sompura, Krishna AU - Sompura K AUID- ORCID: 0000-0003-1202-1485 AD - Faculty of Pharmacy, Parul Institute of Pharmacy, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. krishna.sompura26855@paruluniversity.ac.in. FAU - Kshatriya, Pranav AU - Kshatriya P AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Rohit, Kaushal AU - Rohit K AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Modi, Ekta AU - Modi E AD - Parul Sevashram Hospital, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Ganguly, Parthasarathi AU - Ganguly P AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - BMC Health Serv Res JT - BMC health services research JID - 101088677 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - India MH - *Continuity of Patient Care/statistics & numerical data MH - Adult MH - *Maternal Health Services/statistics & numerical data MH - Adolescent MH - Pregnancy MH - Young Adult MH - *Health Knowledge, Attitudes, Practice MH - Prenatal Care/statistics & numerical data MH - Surveys and Questionnaires PMC - PMC13625414 OTO - NOTNLM OT - Antenatal and postnatal care OT - Family support OT - Gujarat OT - Maternal health OT - Preconception health OT - Safe motherhood COIS- Declarations. Ethics approval and consent to participate: Parul University - Institutional Ethics Committee approval on Human Research no. ECR/702/Inst/GJ/2015/RR-21/10206. All procedures involving human participants/data were conducted in accordance with institutional ethical standards and the Declaration of Helsinki. Ethical approval was obtained from the Institutional Ethics Committee, and informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:54 MHDA- 2026/09/30 05:30 PMCR- 2026/07/11 CRDT- 2026/07/11 23:36 PHST- 2026/04/20 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/09/30 05:30 [medline] PHST- 2026/07/12 00:54 [pubmed] PHST- 2026/07/11 23:36 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s12913-026-15063-3 [pii] AID - 15063 [pii] AID - 10.1186/s12913-026-15063-3 [doi] PST - epublish SO - BMC Health Serv Res. 2026 Jul 11;26(1):1325. doi: 10.1186/s12913-026-15063-3. PMID- 42436436 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1472-6920 (Electronic) IS - 1472-6920 (Linking) VI - 26 IP - 1 DP - 2026 Jul 11 TI - Refeeding syndrome knowledge among healthcare providers in a tertiary care pediatric center: a pre- and post-effective education & awareness test analysis. LID - 10.1186/s12909-026-09812-5 [doi] LID - 1588 AB - BACKGROUND: Refeeding syndrome (RFS) is a potentially fatal condition with reported pediatric intensive care incidence rates up to 7.4%. Despite heightened vulnerability in children due to higher metabolic rates, substantial knowledge deficits persist among pediatric healthcare providers regarding RFS recognition and management, creating critical patient safety risks. OBJECTIVE: To evaluate the effectiveness of a comprehensive multimodal educational intervention in improving refeeding syndrome knowledge among pediatric healthcare providers in a tertiary care setting. METHODS: A prospective pre-post interventional study was conducted from November 2024 to May 2025. Following baseline knowledge assessment using a validated 16-item questionnaire, participants received a 6-month structured educational intervention comprising lectures, evidence-based guidelines, multimedia resources, and reinforcement activities. Post-intervention assessment evaluated knowledge improvement across fundamental understanding and clinical management domains. RESULTS: Sixty-nine participants completed baseline assessment, with 62 completing follow-up (89.9% retention). Significant improvements occurred across all domains: comprehensive RFS definition recognition (58.5% to 83.9%, p = 0.002), metabolic disturbance understanding (60.3% to 87.3%, p = 0.0006), timing recognition (44.6% to 77.4%, p = 0.002), risk stratification (43.5% to 71.0%, p = 0.001), electrolyte monitoring protocols (39.1% to 74.2%, p < 0.001), and clinical scenario management (43.5% to 79.0%, p < 0.001). Excellent fundamental knowledge performance increased from 47.8% to 79.0%, while poor performance decreased from 18.8% to 3.2% (p < 0.001). Fellows and senior residents demonstrated greater improvement than junior residents, suggesting experience-dependent educational responsiveness. CONCLUSIONS: Structured multimodal educational interventions produce substantial, clinically meaningful improvements in pediatric RFS knowledge across all competency domains. These findings support implementing systematic RFS education programs in pediatric institutions to enhance patient safety, with particular attention to experience-appropriate content delivery for optimal educational effectiveness. CI - (c) 2026. The Author(s). FAU - AlKateb, Faten Ahmad AU - AlKateb FA AUID- ORCID: 0000-0002-8672-6034 AD - Department of General Paediatrics, King Fahad Medical City, Riyadh, Saudi Arabia. fatenmil@yahoo.com. FAU - Alanazy, Nora Khalid AU - Alanazy NK AD - Department of General Paediatrics, King Fahad Medical City, Riyadh, Saudi Arabia. FAU - Basakran, Asma Fayez AU - Basakran AF AD - Department of General Paediatrics, King Fahad Medical City, Riyadh, Saudi Arabia. Asma.baskran@gmail.com. FAU - Mehmadi, Sameer AU - Mehmadi S AD - Department of Paediatric Neurology, King Faisal Specialized Hospital, Riyadh, Saudi Arabia. LA - eng GR - 025-008/King Fahd Medical City/ PT - Journal Article DEP - 20260711 PL - England TA - BMC Med Educ JT - BMC medical education JID - 101088679 SB - IM MH - Humans MH - Prospective Studies MH - *Refeeding Syndrome/therapy/diagnosis MH - Tertiary Care Centers MH - Female MH - *Health Knowledge, Attitudes, Practice MH - *Health Personnel/education MH - *Clinical Competence MH - Male MH - Pediatrics/education MH - Educational Measurement MH - Surveys and Questionnaires MH - Child PMC - PMC13644186 OTO - NOTNLM OT - Educational intervention OT - Healthcare providers OT - Knowledge assessment OT - Patient safety OT - Pediatric care OT - Refeeding syndrome COIS- Declarations. Ethics approval and consent to participate: This study was approved by the institutional review board of King Fahad Medical City, Riyadh, Saudi Arabia (Approval No. 24-410). The study was conducted in accordance with the ethical principles of the Declaration of Helsinki. Written informed consent was obtained from all participants. Consent for publication: all authors have given consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:54 MHDA- 2026/10/07 05:31 PMCR- 2026/07/11 CRDT- 2026/07/11 23:35 PHST- 2025/07/29 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/10/07 05:31 [medline] PHST- 2026/07/12 00:54 [pubmed] PHST- 2026/07/11 23:35 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s12909-026-09812-5 [pii] AID - 9812 [pii] AID - 10.1186/s12909-026-09812-5 [doi] PST - epublish SO - BMC Med Educ. 2026 Jul 11;26(1):1588. doi: 10.1186/s12909-026-09812-5. PMID- 42436401 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1471-2342 (Electronic) IS - 1471-2342 (Linking) VI - 26 IP - 1 DP - 2026 Jul 11 TI - Linking vertebral trabecular structure to growth rate: clinical and developmental insights. LID - 10.1186/s12880-026-02583-x [doi] LID - 507 AB - OBJECTIVES: To evaluate the effectiveness of chronological age (CA), sex, and fractal dimension (FD) values in classifying skeletal maturation stages using multinomial logistic regression analysis. MATERIALS AND METHODS: Lateral cephalometric radiographs and hand-wrist radiographs (HWRs) of 923 individuals (409 boys and 514 girls) aged 7-18 years were analyzed. Nine regions of interest located in the C2, C3, and C4 vertebral bodies were selected for the fractal analysis. Skeletal maturation stages were determined using Fishman's skeletal maturity indicator (SMI) method and categorized into accelerating (n = 201; 141 boys and 60 girls), high (n = 334; 165 boys and 169 girls), and decreasing (n = 388; 103 boys and 285 girls) growth velocity groups. Multinomial logistic regression was used to evaluate the associations of CA, sex, and FD values with maturation group membership. Relative risk ratios (RRRs) and 95% confidence intervals (CIs) were calculated to assess the effects of CA, sex, and FD values on maturation stage classification. RESULTS: The full model was statistically significant compared with the intercept-only model and achieved an overall apparent classification accuracy of 77.8%. The age-and-sex-only model had a Nagelkerke R(2) of 0.768 and an accuracy of 77.2%, whereas the full model including FD variables had a Nagelkerke R(2) of 0.779 and an accuracy of 77.8%. These results indicate that FD measurements provided a modest additional contribution beyond CA and sex. CA and sex were the most stable predictors. Among FD variables, C2 anterior FD showed a significant overall effect, while C4 medial and C4 posterior FD showed more limited, category-specific associations. CONCLUSION: CA and sex were the primary predictors of maturation group membership. FD values from selected cervical vertebral regions may provide supplementary information, but their contribution was modest and should be interpreted cautiously until externally validated. CLINICAL RELEVANCE: Cervical vertebral fractal analysis may provide supplementary information for skeletal maturation assessment when combined with chronological age and sex; however, external validation is required. CI - (c) 2026. The Author(s). FAU - Gonca, Merve AU - Gonca M AD - Faculty of Dentistry, Department of Orthodontics, Eskisehir Osmangazi University, Eskisehir, Turkiye. FAU - Sert, Mehmet Fatih AU - Sert MF AD - Department of Business Administration (Quantitative Methods), Gaziantep University, Gaziantep, Turkiye. FAU - Gunacar, Dilara Nil AU - Gunacar DN AD - Faculty of Dentistry, Department of Oral and Dentomaxillofacial Radiology, Recep Tayyip Erdogan University, Rize, Turkiye. FAU - Kose, Taha Emre AU - Kose TE AD - Faculty of Dentistry, Department of Oral and Dentomaxillofacial Radiology, Recep Tayyip Erdogan University, Rize, Turkiye. FAU - Beser Gul, Busra AU - Beser Gul B AD - Faculty of Dentistry, Department of Orthodontics, Recep Tayyip Erdogan University, Rize, Turkey. busra.beser@erdogan.edu.tr. FAU - Uygun, Samet AU - Uygun S AD - Faculty of Dentistry, Department of Orthodontics, Recep Tayyip Erdogan University, Rize, Turkey. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - BMC Med Imaging JT - BMC medical imaging JID - 100968553 SB - IM MH - Humans MH - Female MH - Child MH - Male MH - Adolescent MH - *Age Determination by Skeleton/methods MH - Cephalometry MH - Fractals MH - *Cervical Vertebrae/growth & development/diagnostic imaging MH - Logistic Models MH - Sex Factors MH - *Cancellous Bone/diagnostic imaging/growth & development PMC - PMC13647740 OTO - NOTNLM OT - Algorithms OT - Fractals OT - Growth and development OT - Machine learning OT - Orthodontics OT - Vertebrae COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki and its subsequent amendments. The Institutional Review Board and Clinical Ethics Committee of Recep Tayyip Erdogan University Medicine Faculty approved this retrospective clinical study (decision date and number: 24.04.2024/78). For participants under 16 years of age, detailed information about this research was provided to their parents or legal guardians before the study, and an informed consent form was obtained. For participants aged 16 and older, informed consent was obtained directly from the individuals themselves. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 04:10 MHDA- 2026/10/08 05:31 PMCR- 2026/07/11 CRDT- 2026/07/11 23:34 PHST- 2026/03/16 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/12 04:10 [pubmed] PHST- 2026/07/11 23:34 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s12880-026-02583-x [pii] AID - 2583 [pii] AID - 10.1186/s12880-026-02583-x [doi] PST - epublish SO - BMC Med Imaging. 2026 Jul 11;26(1):507. doi: 10.1186/s12880-026-02583-x. PMID- 42436365 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1471-2180 (Electronic) IS - 1471-2180 (Linking) VI - 26 IP - 1 DP - 2026 Jul 11 TI - Clinical presentation and detection of SARS-CoV-2, influenza-A/B among patients with upper respiratory tract infections in a tertiary hospital in Pune: a pilot study. LID - 10.1186/s12866-026-05307-x [doi] LID - 630 AB - BACKGROUND: Acute respiratory illness (ARI) is one of the most common illnesses globally, affecting all age groups and leading to both upper respiratory tract infections (URTIs) and lower respiratory tract infections (LRTIs). Viral pathogens such as influenza viruses and SARS-CoV-2 are major contributors to upper respiratory tract infections and continue to pose significant clinical and public health challenges. AIM: This study aimed to compare the clinical presentation and haematological profiles of adult patients with rRT-PCR-confirmed SARS-CoV-2, Influenza A, Influenza B, and virus-negative URTIs presenting to a tertiary-care hospital in Pune. MATERIALS AND METHODS: Nasopharyngeal swab samples collected from 123 adult patients presenting with URTI between March and November 2023 were tested at the ICMR-National Institute of Virology (NIV), Pune, using multiplex real-time reverse transcription polymerase chain reaction (rRT-PCR) assays for detection of SARS-CoV-2, Influenza A/B, and other respiratory viral pathogens. RNA extraction was performed using a Zybio kit, and a multiplex single-tube combo rRT-PCR assay. RESULTS: The study examined 123 individuals with upper respiratory tract infections (URTIs), 12 of whom had influenza A, 8 of whom had influenza B, and 6 of whom had SARS-CoV-2. No significant differences were observed in age, anthropometric parameters, vital signs, or comorbidity distribution across groups. Significant intergroup differences were identified in cough, sputum production, vomiting/nausea, and nasal discharge/stuffiness (all p < 0.05). Haematological analysis demonstrated significant variations in total WBC count, lymphocyte, monocyte, and neutrophil percentages. Significant intergroup differences were also observed for NLR (p = 0.0013) and PLR (p = 0.0134). CONCLUSION: This pilot study identified differences in selected symptom profiles and haematological parameters and derived inflammatory indices among patients with SARS-CoV-2, Influenza A, Influenza B, and virus-negative URTIs. These findings may contribute to a better understanding of respiratory infection patterns in clinical settings; however, larger studies are required to validate their diagnostic and clinical significance. CI - (c) 2026. The Author(s). FAU - Jali, Priyanka AU - Jali P AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. FAU - Potdar, Varsha AU - Potdar V AD - Scientist 'E' and Influenza Group, ICMR-National Institute of Virology, Ambedkar Road, Pune, India. FAU - Pardeshi, Anil AU - Pardeshi A AD - Global Research Cell, Dr. D. Y. Patil Dental College and Hospital, Pimpri Dr. D. Y. Patil Vidyapeeth (deemed to be University), Pune, 411018, India. anil.pardeshi@dpu.edu.in. FAU - Suryawanshi, Poonam AU - Suryawanshi P AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. FAU - Gandhi, Madhura AU - Gandhi M AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. FAU - Sarawade, Shrishail AU - Sarawade S AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. FAU - Kanitkar, Shubhangi AU - Kanitkar S AD - Department of General Medicine, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Vikhe, Vikram AU - Vikhe V AD - Department of General Medicine, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Barthwal, Madhusudan AU - Barthwal M AD - Department of Respiratory Medicine, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Dole, Sachin AU - Dole S AD - Department of Respiratory Medicine, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Chavan, Hanumant AU - Chavan H AD - Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Parag, Ratnakar AU - Parag R AD - Central Clinical Laboratory, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Bhattad, Divya AU - Bhattad D AD - ICMR-National Institute of Virology, Camp, Next to Marathi Church, Ambedkar Road, Post Box No. 11, Pune, 411001, India. FAU - Jadhav, Sheetal AU - Jadhav S AD - ICMR-National Institute of Virology, Camp, Next to Marathi Church, Ambedkar Road, Post Box No. 11, Pune, 411001, India. FAU - Vipat, Veena AU - Vipat V AD - ICMR-National Institute of Virology, Camp, Next to Marathi Church, Ambedkar Road, Post Box No. 11, Pune, 411001, India. FAU - Tripathy, Srikanth AU - Tripathy S AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. srikanthtripathy@gmail.com. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - BMC Microbiol JT - BMC microbiology JID - 100966981 SB - IM MH - Humans MH - Pilot Projects MH - Female MH - Tertiary Care Centers MH - Male MH - *Respiratory Tract Infections/virology/diagnosis/epidemiology MH - Middle Aged MH - Adult MH - *SARS-CoV-2/isolation & purification/genetics MH - *Influenza, Human/diagnosis/virology/epidemiology MH - *Influenza B virus/isolation & purification/genetics MH - India/epidemiology MH - *Influenza A virus/isolation & purification/genetics MH - *COVID-19/diagnosis/epidemiology/virology MH - Aged MH - Young Adult MH - Nasopharynx/virology MH - Adolescent PMC - PMC13374207 OTO - NOTNLM OT - Acute respiratory illness (ARI) OT - Haematological parameters OT - Influenza OT - SARS-CoV-2 OT - Upper respiratory tract infections (URTIs) OT - rRT-PCR COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with institutional and national ethical guidelines and in compliance with the principles of the Declaration of Helsinki. Prior to study initiation, ethical approval was obtained from the Institutional Ethics Committee of ICMR-National Institute of Virology, Pune (IEC Approval No: NIV-IEC/Oct/2021/D-5). Written informed consent was obtained from all participants before enrolment in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:54 MHDA- 2026/07/17 12:41 PMCR- 2026/07/11 CRDT- 2026/07/11 23:33 PHST- 2026/03/31 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/07/17 12:41 [medline] PHST- 2026/07/12 00:54 [pubmed] PHST- 2026/07/11 23:33 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s12866-026-05307-x [pii] AID - 5307 [pii] AID - 10.1186/s12866-026-05307-x [doi] PST - epublish SO - BMC Microbiol. 2026 Jul 11;26(1):630. doi: 10.1186/s12866-026-05307-x. PMID- 42435637 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260919 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 130 DP - 2026 Oct TI - Clinical assessment and normative values of turning: The effects of age, sex, and military status on turning speed. PG - 110284 LID - S0966-6362(26)00194-3 [pii] LID - 10.1016/j.gaitpost.2026.110284 [doi] AB - INTRODUCTION: Ambulatory turning is a fundamental component of everyday mobility and military readiness, yet standard clinical assessments do not examine turns, an important component of mobility. The objective is to investigate which demographic and anthropometric factors, and military status impact peak turning velocities during complex and ecologically valid turning tasks and to report normative data. METHODS: Data from 94 healthy civilians and 40 service members, aged 18-50 years, were included. Participants performed a straight-path walk with 180 degrees turns, the modified Illinois Agility Test (mIAT) with slalom, end, and middle turns, and a Complex Turning Course (CTC) with 45 degrees , 90 degrees , and 135 degrees turns Peak turning velocities were measured using a wearable sensor placed around the waist. Multiple linear regression models were used to assess the influence of military status, sex, age, and body mass index (BMI) on turning velocities. RESULTS: Military status and sex were significant predictors of peak turning velocities. Specifically, service members turned significantly faster during slalom turns while running and during 45 degrees , 90 degrees , and 135 degrees turns, and female participants exhibited faster turning during 180 degrees turns and slalom turns. We also report the normative values of peak turning velocities for each turn type, stratified by military status and sex. CONCLUSION: Military status and sex were the primary demographic factors that affected turning performance. The normative values presented in this study provide a benchmark for clinicians to identify subtle turning deficits to monitor rehabilitation progress in neurological populations, and to make return-to-activity decisions for individuals with impaired mobility. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Lee, Jae W AU - Lee JW AD - Department of Neurology, Oregon Health & Science University, Portland, OR, United States. Electronic address: lejae@ohsu.edu. FAU - Fino, Peter C AU - Fino PC AD - Department of Health and Kinesiology, University of Utah, Salt Lake City, UT, United States. FAU - Michielutti, Patrick G AU - Michielutti PG AD - Courage Kenny Research Center-Allina Health, Minneapolis, MN, United States. FAU - Weston, Angela R AU - Weston AR AD - Army-Baylor University Doctoral Program in Physical Therapy, Joint Base San Antonio - Fort Sam Houston, San Antonio, TX, United States. FAU - Hoppes, Carrie W AU - Hoppes CW AD - Advanced Exposures, Diagnostics, Interventions, and Biosecurity (AEGIS) Program, Joint Base San Antonio-Lackland Air Force Base, San Antonio, TX, United States. FAU - Dibble, Leland E AU - Dibble LE AD - Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, UT, United States. FAU - King, Laurie A AU - King LA AD - Department of Neurology, Oregon Health & Science University, Portland, OR, United States; National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System, Portland, OR, United States. FAU - Weightman, Margaret M AU - Weightman MM AD - Courage Kenny Research Center-Allina Health, Minneapolis, MN, United States. LA - eng GR - AWARD NO. W81XWH1820049/Department of War/ PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20260710 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Humans MH - Female MH - *Military Personnel MH - Adult MH - Male MH - Adolescent MH - Reference Values MH - Young Adult MH - Middle Aged MH - Age Factors MH - Sex Factors MH - Biomechanical Phenomena MH - *Gait/physiology OTO - NOTNLM OT - Dual task OT - Inertial sensors OT - Military personnel OT - Normative data OT - Turning COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/12 00:54 MHDA- 2026/08/22 23:43 CRDT- 2026/07/11 18:05 PHST- 2026/03/03 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/07/12 00:54 [pubmed] PHST- 2026/07/11 18:05 [entrez] AID - S0966-6362(26)00194-3 [pii] AID - 10.1016/j.gaitpost.2026.110284 [doi] PST - ppublish SO - Gait Posture. 2026 Oct;130:110284. doi: 10.1016/j.gaitpost.2026.110284. Epub 2026 Jul 10. PMID- 42435268 OWN - NLM STAT- MEDLINE DCOM- 20260802 LR - 20261008 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 36 IP - 8 DP - 2026 Aug TI - Short-Term Clinical and Metabolic Outcomes of Laparoscopic Sleeve Gastrectomy in Korean Adolescents with Severe Obesity: A Retrospective Analysis. PG - 4408-4414 LID - 10.1007/s11695-026-08844-6 [doi] AB - BACKGROUND: Severe obesity and its associated comorbidities in adolescents pose a growing global health challenge. Although laparoscopic sleeve gastrectomy (LSG) has emerged as an effective treatment option, clinical evidence in Asian populations remains limited. Therefore, we aimed to evaluate the short-term clinical and metabolic outcomes of LSG in severely obese Korean adolescents. METHODS: Between 2020 and 2025, a total of 1,824 bariatric surgeries were conducted at Incheon Sejong Hospital, among which 24 adolescent cases of LSG were identified for retrospective analysis. Demographic characteristics, body composition, perioperative laboratory findings, and postoperative weight loss outcomes were analyzed. RESULTS: A total of 24 adolescent patients who underwent LSG for severe obesity were included. At 12 months postoperatively, patients achieved significant weight loss, with a mean percentage of excess weight loss of 84.12% and percentage of excess body mass index loss of 84.43%. Body composition analysis at 12 months postoperatively revealed a 51.12% reduction in fat mass, whereas muscle mass was relatively preserved (16.67% loss). Metabolic profiles improved significantly, as evidenced by a decrease in triglycerides (167.3 to 67.9 mg/dL, p = 0.001) and fasting C-peptide (4.0 to 2.4 mg/dL, p = 0.009). Regarding hepatic steatosis and fibrosis, the controlled attenuation parameter and liver stiffness measurement decreased from 337 to 246 dB/m and 7.1 to 5.1 kPa, respectively. CONCLUSIONS: LSG demonstrated favorable safe and feasible intervention for Korean adolescents with severe obesity within this cohort, achieving significant weight loss and rapid improvements in metabolic and hepatic parameters within the first postoperative year. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Lee, Jeong-Seon AU - Lee JS AD - Department of Pediatrics, Incheon Sejong Hospital, Incheon, Republic of Korea. FAU - Lee, Sungbae AU - Lee S AD - Department of Surgery, Incheon Sejong Hospital, Incheon, Korea, Republic of. FAU - Jung, Sungwoo AU - Jung S AD - Department of Surgery, Incheon Sejong Hospital, Incheon, Korea, Republic of. FAU - Kim, Ji Hyung AU - Kim JH AD - Bariatric and Metabolic Surgery Center, Incheon Sejong Hospital, Incheon, Korea, Republic of. FAU - Lee, Okjoo AU - Lee O AUID- ORCID: 0000-0003-1077-2592 AD - Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. altanis7@gmail.com. LA - eng PT - Journal Article DEP - 20260711 PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 SB - IM MH - Humans MH - Adolescent MH - Female MH - Retrospective Studies MH - Male MH - *Laparoscopy/methods MH - *Obesity, Morbid/surgery/metabolism MH - *Gastrectomy/methods MH - Republic of Korea/epidemiology MH - Weight Loss MH - Treatment Outcome MH - *Pediatric Obesity/surgery/metabolism MH - Body Mass Index MH - Body Composition OTO - NOTNLM OT - Adolescent OT - Gastrectomy OT - Laparoscopy OT - Obesity, morbid OT - Treatment outcome COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:54 MHDA- 2026/08/02 13:45 CRDT- 2026/07/11 11:16 PHST- 2026/03/31 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/06/05 00:00 [revised] PHST- 2026/08/02 13:45 [medline] PHST- 2026/07/12 00:54 [pubmed] PHST- 2026/07/11 11:16 [entrez] AID - 10.1007/s11695-026-08844-6 [pii] AID - 10.1007/s11695-026-08844-6 [doi] PST - ppublish SO - Obes Surg. 2026 Aug;36(8):4408-4414. doi: 10.1007/s11695-026-08844-6. Epub 2026 Jul 11. PMID- 42434894 OWN - NLM STAT- Publisher LR - 20260812 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Jul 11 TI - Maternal insights on infant solid food introduction: Implications for nutrition and public health. PG - 2601060261467797 LID - 10.1177/02601060261467797 [doi] AB - BackgroundEarly-life nutrition is critical for infant growth, development, and long-term health. National feeding guidelines such as the Nutrition for Healthy Term Infants (NHTI) recommendations aim to support optimal infant feeding.AimTo explore mothers' knowledge, attitudes, practices (KAPs) and suggestions regarding the NHTI feeding recommendations for introducing solid foods.MethodsUsing qualitative description, we purposefully recruited mothers >/=18 years with healthy infants /=5 mg/L) or missing metabolic variables. IR was defined as Homeostatic Model Assessment for Insulin Resistance (HOMA IR) exceeding 3.0. Least Absolute Shrinkage and Selection Operator (LASSO) regression selected nine predictors from 27 candidate variables (demographics, anthropometrics, blood pressure, hematology, glucose metabolism, lipids, hepatic and renal function). Four ML algorithms [logistic regression (LR), random forest (RF), k-nearest neighbor (KNN), and extreme gradient boosting (XGBoost)] were developed and evaluated by area under the curve, sensitivity, specificity, and calibration, with five-fold repeated cross-validation for internal validation. SHapley Additive exPlanations (SHAP) analysis quantified predictor contributions. RESULTS: XGBoost achieved optimal discriminative performance with an external validation area under the receiver operating characteristic curve (AUC) of 0.940 [95% confidence interval (CI): 0.889-0.991], outperforming other algorithms. RF demonstrated the highest training AUC (0.993, 95% CI: 0.987-1.000) with near-perfect sensitivity (0.985, 95% CI: 0.920-1.000) but showed limited generalization capacity given minimal training-validation divergence. LR and KNN achieved lower validation AUC values of 0.832 (95% CI: 0.743-0.922) and 0.823 (95% CI: 0.740-0.905), respectively. XGBoost was selected as the final model based on superior specificity (0.967, 95% CI: 0.906-0.993) and tighter CIs, indicating more stable performance estimation. Fasting glucose (mean |SHAP| =0.707) and triglycerides (0.383) emerged as dominant predictors, while albumin demonstrated a protective association [odds ratio (OR) 0.86, 95% CI: 0.78-0.95]. CONCLUSIONS: This study establishes an externally validated, interpretable ML framework for predicting IR among iron-deficient youth using routine clinical data. While the XGBoost model demonstrates promising discriminative performance and geographic generalizability, the modest sample size and single-province validation limit immediate deployment readiness. Prospective multi-site validation is required before any consideration of clinical implementation as a developmental screening framework. CI - (c) AME Publishing Company. FAU - Bai, Jing AU - Bai J AD - Pediatric Department, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Fang, Xiao AU - Fang X AUID- ORCID: 0009-0005-7358-1349 AD - National Science Library (Chengdu), Chinese Academy of Sciences, Chengdu, China. FAU - Ding, Xiaoyan AU - Ding X AD - Pediatric Department, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Huang, Xiu AU - Huang X AD - Pediatric Department, Nanchong City Jialing District People's Hospital (Jialing Branch of Nanchong Central Hospital), Nanchong, China. LA - eng PT - Journal Article DEP - 20260515 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13351654 OTO - NOTNLM OT - Machine learning (ML) OT - children OT - external validation OT - insulin resistance (IR) OT - iron-deficiency COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0146/coif). The authors have no conflicts of interest to declare. EDAT- 2026/07/11 16:11 MHDA- 2026/07/11 16:12 PMCR- 2026/06/30 CRDT- 2026/07/11 05:11 PHST- 2026/02/04 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/11 16:12 [medline] PHST- 2026/07/11 16:11 [pubmed] PHST- 2026/07/11 05:11 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - tp-15-06-231 [pii] AID - 10.21037/tp-2026-1-0146 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jun 30;15(6):231. doi: 10.21037/tp-2026-1-0146. Epub 2026 May 15. PMID- 42433955 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 6 DP - 2026 Jun 30 TI - Associations of picky eating levels with dietary diversity, nutrient intake, and eating behaviors in preschool children with autism spectrum disorder: a cross-sectional study. PG - 214 LID - 10.21037/tp-2026-1-0168 [doi] LID - 214 AB - BACKGROUND: Picky eating is common among children with autism spectrum disorder (ASD). However, the specific effects of different levels of picky eating on nutritional status, dietary diversity, and eating behaviors in preschool-aged children with ASD remain unclear. This study aimed to compare these aspects between children with low versus high levels of picky eating. METHODS: A cross-sectional study design was employed, enrolling 130 children with ASD aged 3 to 6 years who met the DSM-5 diagnostic criteria [Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-V)]. Trained personnel measured each child's height and weight using standardized instruments. Validated dietary diversity scores and preschool eating behavior scales were used to assess dietary diversity and nutrient intake and eating behaviors. energy and macronutrient intake were quantified through three non-consecutive 24-hour dietary recalls. Children were divided into a low picky eating group and a high picky eating group based on the degree of picky eating for comparative analysis. RESULTS: There were no statistically significant differences in height and weight indicators between the two groups, with most children falling within the normal range of growth and development. However, distinct differences were observed in nutrient intake and eating behaviors: children in the low picky eating group showed significantly higher total dietary diversity scores (P<0.05). Regarding nutrient intake, children in the low picky eating group exhibited higher intake levels of total energy, polyunsaturated fatty acids, and dietary fiber compared to those in the high picky eating group; in specific food categories, intake of starchy tubers, fruits, nuts, and legumes was also significantly higher. Regarding eating behaviors, children in the low picky eating group showed lower scores for picky eating and problematic eating behaviors, whereas exhibited heightened satiety responsiveness, with all differences reaching statistical significance (P<0.05). CONCLUSIONS: The degree of picky eating is a key factor influencing dietary quality and eating behaviors in preschool-age children with ASD. Low levels of picky eating are associated with more comprehensive nutrient intake, richer dietary diversity, and more favorable eating behavior patterns. Early identification and intervention targeting picky eating behavior are of significant importance for improving the nutritional status of children with ASD. CI - (c) AME Publishing Company. FAU - Wang, Shasha AU - Wang S AD - Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Qi, Ye AU - Qi Y AD - Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Yao, Dan AU - Yao D AD - Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. LA - eng PT - Journal Article DEP - 20260626 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13351710 OTO - NOTNLM OT - Autism spectrum disorder (ASD) OT - nutritional status OT - picky eating COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0168/coif). The authors have no conflicts of interest to declare. EDAT- 2026/07/11 16:11 MHDA- 2026/07/11 16:12 PMCR- 2026/06/30 CRDT- 2026/07/11 05:11 PHST- 2026/02/14 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/07/11 16:12 [medline] PHST- 2026/07/11 16:11 [pubmed] PHST- 2026/07/11 05:11 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - tp-15-06-214 [pii] AID - 10.21037/tp-2026-1-0168 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jun 30;15(6):214. doi: 10.21037/tp-2026-1-0168. Epub 2026 Jun 26. PMID- 42433928 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 6 DP - 2026 Jun 30 TI - Clinical phenotype, gonadal development, and comorbidity spectrum in 43 children with triple X syndrome: a single-center retrospective descriptive case series with cytogenetic refinement in patients with and without X-monosomy-containing cell lines. PG - 222 LID - 10.21037/tp-2026-0264 [doi] LID - 222 AB - BACKGROUND: Triple X syndrome (TXS) is a common yet under-diagnosed sex chromosome aneuploidy with significant phenotypic heterogeneity. Previous studies have typically described TXS as a homogeneous entity, lacking karyotype-stratified analysis. This study aimed to compare clinical phenotypes, gonadal development, and comorbidity profiles across karyotype subgroups in pediatric TXS patients. METHODS: This retrospective descriptive case series included 43 pediatric patients with TXS diagnosed at Jiangxi Provincial Children's Hospital between January 2019 and November 2024. Patients were classified into three groups: non-mosaic, X-monosomy mosaic (containing 45,X cell lines), and non-X-monosomy mosaic groups. Clinical data, including anthropometric measurements, sex hormones, pelvic ultrasound, bone age, and comorbidities, were collected. G-banding karyotyping was performed in all patients, and fluorescence in situ hybridization (FISH) was additionally performed in selected cases. Given the small subgroup sizes, analyses were descriptive without formal between-group hypothesis testing. RESULTS: Among the 43 patients, 31 (72.1%) were non-mosaic, 9 (20.9%) were X-monosomy mosaic, and 3 (7.0%) were non-X-monosomy mosaic. Fifteen patients (34.9%) experienced spontaneous menarche at a mean age of 11.13+/-1.28 years. The X-monosomy mosaic subgroup showed Turner syndrome-like features, including delayed bone age (mean difference +1.36 years), skeletal anomalies (3/9, 33.3%), and renal anomalies (2/9, 22.2%). Neuropsychiatric disorders were the most common comorbidity overall (11/43, 25.6%), particularly in the non-mosaic group. FISH refinement identified additional low-frequency cell lines in selected patients, highlighting cytogenetic complexity beyond routine karyotyping. CONCLUSIONS: In this descriptive single-center case series, patients with X-monosomy-containing cell lines were observed to have phenotypic features overlapping both Turner syndrome (disproportionate bone age delay, renal/skeletal anomalies) and typical 47,XXX (neuropsychiatric findings). Given the small subgroup sizes and the single-center design, these subgroup-level descriptions are presented to inform future hypothesis-driven studies rather than to support formal between-group conclusions. We outline a tentative, practice-informed framework intended to support-rather than replace-individualized multidisciplinary follow-up; prospective multi-center validation is required before adoption as a clinical management algorithm. CI - (c) AME Publishing Company. FAU - Feng, Ya-Qin AU - Feng YQ AUID- ORCID: 0009-0004-4489-3514 AD - Department of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, China. AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. FAU - Li, Wen-Ting AU - Li WT AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. AD - Department of Clinical Laboratory, Jiangxi Provincial Children's Hospital, Nanchang, China. FAU - Zou, Hai-Ying AU - Zou HY AD - Department of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, China. AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. FAU - Xu, Qing-Bo AU - Xu QB AD - Department of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, China. AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. FAU - Yang, Li AU - Yang L AUID- ORCID: 0009-0003-5209-4766 AD - Department of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, China. AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. LA - eng PT - Journal Article DEP - 20260520 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13351657 OTO - NOTNLM OT - Triple X syndrome (TXS) OT - clinical phenotype OT - comorbidity OT - gonadal development OT - karyotype stratification COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0264/coif). The authors have no conflicts of interest to declare. EDAT- 2026/07/11 06:36 MHDA- 2026/07/11 06:37 PMCR- 2026/06/30 CRDT- 2026/07/11 05:11 PHST- 2026/03/15 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/07/11 06:37 [medline] PHST- 2026/07/11 06:36 [pubmed] PHST- 2026/07/11 05:11 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - tp-15-06-222 [pii] AID - 10.21037/tp-2026-0264 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jun 30;15(6):222. doi: 10.21037/tp-2026-0264. Epub 2026 May 20. PMID- 42433404 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Development and validation of a scale of healthy psychological effects of physical exercise among Chinese college students from a multidimensional mental health perspective. PG - 1866486 LID - 10.3389/fpubh.2026.1866486 [doi] LID - 1866486 AB - BACKGROUND: Physical exercise promotes mental health among college students, but existing studies often assess general mental health or limited psychological indicators, making it difficult to capture comprehensive healthy psychological effects after exercise. This study aimed to develop and validate the Healthy Psychological Effects of Physical Exercise Scale for College Students. METHODS: An initial scale was developed through theoretical analysis, literature review, semi-structured interviews, and open-ended questionnaires. In an initial sample of 612 college students, item analysis and exploratory factor analysis with varimax rotation were conducted to screen items and identify factor structures. A formal sample of 945 participants was used to examine reliability and validity through Cronbach's alpha, composite reliability (CR), average variance extracted (AVE), confirmatory factor analysis (CFA), and criterion-related validity testing. Test-retest reliability was assessed in 597 participants after 1 month. RESULTS: The final scale contained 55 items across five subscales: emotional feelings, self-cognition, frustration coping, self-control and social adaptation efficacy, and interpersonal interaction, comprising 15 subdimensions. Exploratory factor analyses supported clear three-factor structures for each subscale, with cumulative variance explained ranging from 62.546 to 73.711%. CFA indicated good fit for the five subscales (chi(2) /df = 2.978-4.391; RMSEA = 0.046-0.060; SRMR = 0.016-0.021; CFI = 0.978-0.988; TLI = 0.971-0.984), and acceptable fit for the overall model (chi(2) /df = 3.037; RMSEA = 0.046; SRMR = 0.041; CFI = 0.925; TLI = 0.921). Cronbach's alpha and CR for the 15 subdimensions ranged from 0.873 to 0.931, and AVE ranged from 0.680 to 0.736. Cronbach's alpha for the five subscale total scores ranged from 0.861 to 0.894. Test-retest reliability ranged from 0.706 to 0.781 for subdimensions and from 0.686 to 0.771 for subscale total scores. Criterion-related validity was supported by significant positive correlations with positive psychological indicators (r = 0.229-0.383) and negative correlations with negative psychological indicators (r = -0.398 to -0.224; all p < 0.001). CONCLUSION: The scale demonstrates sound reliability and validity and can be used to assess exercise-related healthy psychological effects among college students. CI - Copyright (c) 2026 Liu, Zhu, He, Zhu and Guo. FAU - Liu, Feiyang AU - Liu F AD - School of Physical Education, Southwest University, Chongqing, China. FAU - Zhu, Zhengguang AU - Zhu Z AD - Research Center of Mental Health Education, Southwest University, Chongqing, China. FAU - He, Rongqiao AU - He R AD - School of Physical Education, Southwest University, Chongqing, China. FAU - Zhu, Yu AU - Zhu Y AD - School of Physical Education, Southwest University, Chongqing, China. FAU - Guo, Liya AU - Guo L AD - School of Physical Education, Southwest University, Chongqing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260626 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/psychology/statistics & numerical data MH - Female MH - Universities MH - Reproducibility of Results MH - *Exercise/psychology MH - Young Adult MH - Male MH - Surveys and Questionnaires/standards MH - *Mental Health MH - China MH - Psychometrics MH - Adolescent MH - Factor Analysis, Statistical MH - Adult MH - Adaptation, Psychological PMC - PMC13352479 OTO - NOTNLM OT - college students OT - healthy psychological effects OT - mental health OT - physical exercise OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/11 06:35 MHDA- 2026/07/12 00:55 PMCR- 2026/06/26 CRDT- 2026/07/11 05:06 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/12 00:55 [medline] PHST- 2026/07/11 06:35 [pubmed] PHST- 2026/07/11 05:06 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1866486 [doi] PST - epublish SO - Front Public Health. 2026 Jun 26;14:1866486. doi: 10.3389/fpubh.2026.1866486. eCollection 2026. PMID- 42433322 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2950-5410 (Electronic) IS - 2950-5410 (Linking) VI - 21 DP - 2026 Oct TI - Evaluating Empowerment in Adolescents with a Disability and/or Chronic Condition from Neurology and Orthopedic Clinics: A Mixed-Methods Study. PG - 200220 LID - 10.1016/j.jpedcp.2026.200220 [doi] LID - 200220 AB - OBJECTIVE: To evaluate empowerment and quality of life in adolescents (10-19 years of age) with chronic conditions and/or disabilities from neurology and orthopedic clinics and identify areas to improve their care and empowerment. STUDY DESIGN: We utilized a mixed-methods design with an explanatory sequential approach. Participants were recruited from neurology and orthopedic clinics at BC Children's Hospital and completed a demographic survey and two validated online tools: The Gothenburg Young Person's Empowerment Scale (GYPES) and Pediatric Quality of Life (PedsQL) 4.0 self-report. Semi-structured interviews were conducted to gain a deeper understanding of adolescents' feelings of empowerment. Linear regression analysis was performed to identify demographic variables associated with decreased empowerment and quality of life. Interviews were analyzed using an interpretive description framework. RESULTS: Forty-eight participants completed the survey. The mean reported GYPES and PedsQL scores were 58.15 +/- 8.46 and 61.57 +/- 22.32, respectively. Theoretical sufficiency was reached after 14 interviews. Four environmental factors leading to feelings promoting empowerment were identified: (1) shared decision-making enabled advocacy and independence, (2) education (particularly involving genetics) increased knowledge and understanding, (3) sharing stories led to empowering others, and (4) participation in physical activities promoted a sense of belonging. CONCLUSIONS: This study was the first to use the GYPES in adolescents with diverse disabilities and/or chronic conditions from neurology and orthopedic clinics. Adolescent patients felt empowered when they were actively involved in their health care and informed about the genetics of their diagnosis. Participants also wanted opportunities to empower others going through similar experiences. This study emphasizes the need for access to genetic counseling and opportunities for shared expression to facilitate empowerment. CI - (c) 2026 The Author(s). FAU - Austin, Kennedy AU - Austin K AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. FAU - Selby, Kathryn AU - Selby K AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. FAU - Virani, Alice AU - Virani A AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - Ethics Service, Provincial Health Services Authority, Vancouver, BC, Canada. FAU - Ross, Colin AU - Ross C AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Centre for Advancing Health Outcomes, St Paul's Hospital, Vancouver, BC, Canada. AD - Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. FAU - Chhina, Harpreet AU - Chhina H AD - Department of Orthopedics, University of British Columbia, Vancouver, BC, Canada. FAU - Cooper, Anthony AU - Cooper A AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Department of Orthopedics, University of British Columbia, Vancouver, BC, Canada. AD - Department of Orthopedics, BC Children's Hospital, Vancouver, BC, Canada. FAU - Elliott, Alison M AU - Elliott AM AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Women's Health Research Institute, Vancouver, BC, Canada. LA - eng PT - Journal Article DEP - 20260606 PL - United States TA - J Pediatr Clin Pract JT - Journal of pediatrics. Clinical practice JID - 9918769578606676 PMC - PMC13352426 OTO - NOTNLM OT - adolescents OT - chronic condition OT - disability OT - empowerment COIS- K.A. was the recipient of the 10.13039/501100000024Canadian Institutes of Health Research (CIHR) Canadian Graduate Scholarship Master's award, through which this project was funded. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/11 06:35 MHDA- 2026/07/11 06:36 PMCR- 2026/06/06 CRDT- 2026/07/11 05:05 PHST- 2025/12/04 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/07/11 06:36 [medline] PHST- 2026/07/11 06:35 [pubmed] PHST- 2026/07/11 05:05 [entrez] PHST- 2026/06/06 00:00 [pmc-release] AID - S2950-5410(26)00021-9 [pii] AID - 200220 [pii] AID - 10.1016/j.jpedcp.2026.200220 [doi] PST - epublish SO - J Pediatr Clin Pract. 2026 Jun 6;21:200220. doi: 10.1016/j.jpedcp.2026.200220. eCollection 2026 Oct. PMID- 42433286 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Sports and physical activity interventions in autism spectrum disorder: a systematic literature review and meta-analysis. PG - 1793290 LID - 10.3389/fspor.2026.1793290 [doi] LID - 1793290 AB - BACKGROUND: Physical activity (PA) interventions have been explored as a means of improving motor, social, executive, behavioural, and psychosocial outcomes in children and adolescents with autism spectrum disorder (ASD). However, variability in study designs and methodological quality raises questions about the consistency and reliability of reported effects. METHODS: A systematic review and meta-analysis were conducted, including studies published between 2019 and 2025. Eighteen studies met the inclusion criteria for qualitative synthesis, and twelve were included in the meta-analysis using a random-effects model. Effect sizes were calculated and pooled across outcome domains. Risk of bias was assessed, and additional analyses were conducted to examine heterogeneity and potential publication bias. RESULTS: PA interventions were associated with improvements across multiple domains. The pooled effect size was large (d approximately 1.28), but substantial heterogeneity across study designs, intervention types, and sample characteristics was observed. Subgroup analyses indicated variation in effects across intervention types and participant groups, though findings were not consistently stable. Risk-of-bias assessments identified several methodological limitations, and publication bias analyses suggested possible asymmetry. These factors indicate that the magnitude of the pooled effect size may be overestimated. CONCLUSION: PA interventions show promise for supporting multidomain development in children and adolescents with ASD. However, the certainty of evidence ranges from low to moderate, and findings should be interpreted cautiously. Future research should prioritise rigorous study designs, larger samples, and consistent reporting of intervention fidelity and long-term outcomes to strengthen the evidence base. CI - (c) 2026 Jacob, Nurhayati and Maguvhe. FAU - Jacob, Udeme Samuel AU - Jacob US AD - Department of Inclusive Education, School of Educational Studies, College of Education, University of South Africa, Pretoria, South Africa. FAU - Nurhayati, Sri AU - Nurhayati S AD - Department of Community Education, Postgraduate Program, Institut Keguruan dan Ilmu Pendidikan Siliwangi, Cimahi, Indonesia. FAU - Maguvhe, Mbulaheni Obert AU - Maguvhe MO AD - Department of Inclusive Education, School of Educational Studies, College of Education, University of South Africa, Pretoria, South Africa. LA - eng PT - Journal Article DEP - 20260626 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13350350 OTO - NOTNLM OT - autism spectrum disorder OT - children and adolescents OT - executive function OT - intervention OT - meta-analysis OT - motor skills OT - physical activity OT - social communication COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/11 06:35 MHDA- 2026/07/11 06:36 PMCR- 2026/06/26 CRDT- 2026/07/11 05:04 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/07/11 06:36 [medline] PHST- 2026/07/11 06:35 [pubmed] PHST- 2026/07/11 05:04 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.3389/fspor.2026.1793290 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jun 26;8:1793290. doi: 10.3389/fspor.2026.1793290. eCollection 2026. PMID- 42433186 OWN - NLM STAT- Publisher LR - 20260711 IS - 1535-2900 (Electronic) IS - 1079-2082 (Linking) DP - 2026 Jul 11 TI - Clinical controversies in the management of candidemia in adults and children. LID - zxag212 [pii] LID - 10.1093/ajhp/zxag212 [doi] AB - PURPOSE: Candidemia remains associated with substantial morbidity and mortality despite advances in antifungal therapy, yet multiple aspects of management remain controversial. This review synthesizes emerging evidence to address unresolved clinical dilemmas in candidemia management. SUMMARY: This publication reviews data on optimized antifungal dosing, rapid diagnostic tests (RDTs), antifungal susceptibility testing (AFST), echinocandin-to-azole transition, treatment duration, ophthalmologic screening, echocardiographic evaluation, Candida endocarditis, the place in therapy of rezafungin, antifungal resistance, and dosing considerations in children. Substantial pharmacokinetic variability in critically ill and obese patients supports individualized dosing strategies to reduce underexposure. Echinocandin-to-azole transition after 3 to 5 days appears safe in clinically stable patients with bloodstream sterilization and predicted or confirmed azole susceptibility. Although the standard 14-day duration remains a guideline-supported recommendation, emerging evidence suggesting shorter durations may be feasible in carefully selected patients with truly uncomplicated candidemia. Risk-based approaches to ophthalmologic screening and echocardiography may improve diagnostic stewardship while reducing unnecessary testing. Echinocandins appear at least as effective and safer than amphotericin B for Candida endocarditis. Rezafungin offers a practical once-weekly alternative for select patients requiring prolonged intravenous therapy, although evidence for deep-seated infection remains limited. Increasing resistance among non-albicans Candida species, particularly C. parapsilosis, C. glabrata, and C. auris further reinforces the importance of AFST and ongoing surveillance. CONCLUSION: Optimal candidemia management increasingly depends on individualized antifungal strategies, integration of RDTs and AFST, earlier species-directed therapy transitions, and selective evaluation for metastatic complications. Future studies are needed to better define uncomplicated candidemia, optimize treatment duration, and address evolving antifungal resistance. CI - (c) American Society of Health-System Pharmacists 2026. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Cluck, David B AU - Cluck DB AD - Department of Pharmacy Practice, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN, USA. FAU - White, Bryan P AU - White BP AD - University of Oklahoma Medical Center, Oklahoma City, OK, USA. FAU - Hilzendager, Sarah A AU - Hilzendager SA AD - University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA. FAU - Ryder, Jonathan H AU - Ryder JH AD - Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA. FAU - Tu, Patrick J AU - Tu PJ AD - Department of Pharmacy, Charlie Norwood VA Medical Center, Augusta, GA, USA. FAU - McPherson, Amanda Z AU - McPherson AZ AD - University of Georgia College of Pharmacy, Augusta, GA, USA. FAU - Rogers, Daniel J AU - Rogers DJ AD - Emory Decatur Hospital, Decatur, GA, USA. FAU - Chastain, Daniel B AU - Chastain DB AD - University of Georgia College of Pharmacy, Augusta, GA, USA. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - Am J Health Syst Pharm JT - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists JID - 9503023 SB - IM OTO - NOTNLM OT - adult OT - antifungal agents OT - azoles OT - candidemia OT - child OT - diagnostic stewardship OT - echinocandins OT - rezafungin EDAT- 2026/07/11 16:11 MHDA- 2026/07/11 16:11 CRDT- 2026/07/11 04:32 PHST- 2025/07/24 00:00 [received] PHST- 2026/05/25 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/07/11 16:11 [medline] PHST- 2026/07/11 16:11 [pubmed] PHST- 2026/07/11 04:32 [entrez] AID - 8732379 [pii] AID - 10.1093/ajhp/zxag212 [doi] PST - aheadofprint SO - Am J Health Syst Pharm. 2026 Jul 11:zxag212. doi: 10.1093/ajhp/zxag212. PMID- 42433020 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260811 IS - 2041-3033 (Electronic) IS - 0954-4119 (Linking) VI - 240 IP - 8 DP - 2026 Aug TI - Practical evaluation of skin temperature sensors in children during three phases: Clinical differences between contact and infrared methods. PG - 861-875 LID - 10.1177/09544119261465864 [doi] AB - Selecting skin temperature screening methods is difficult due to the wide variety of measurement techniques and equipment currently available. The hypothesis behind the various skin temperature measurement techniques is that contact methods can change the local skin temperature, whereas non-contact methods are sensitive to environmental elements and require consistent placement. The study aimed to compare contact and non-contact temperature sensors for measuring skin temperature in children's lower limbs. An experimental study was conducted by utilising NTC thermistors and an infrared thermometer. Seventy children were recruited to participate in this study. Measurements were conducted during three separate trials, which spanned three experimental phases: before, during, and after exercise. The study protocol included 5 min of sitting and resting before the exercise, 5 min of standing in runner's pose/single-leg march during the exercise, and 5 min of sitting and resting afterwards. Skin temperature data were collected over 20-min intervals for each test. Descriptive statistics and statistical differences among the three tests are illustrated. In three test trials, across all phases, scatter plots consistently revealed a robust, strong correlation between NCTS and CTS readings. NCTS systematically demonstrated higher mean temperature readings when compared to CTS under all conditions. Across all tests and phases, paired samples t-tests revealed that the mean differences between NCTS and CTS were statistically significant (p < 0.001). The greatest discrepancies and biggest effect sizes were detected in the after-exercise phase, which peaks in Test 3 (M(diff) = 2.78 degrees C, ES = 1.46). CTS methods are more reliable and precise for tracking paediatric exercise. FAU - Elghailassi, Ibtissam AU - Elghailassi I AUID- ORCID: 0009-0003-5009-6389 AD - Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia. FAU - Abd Razak, Nasrul Anuar AU - Abd Razak NA AUID- ORCID: 0000-0002-1911-015X AD - Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia. FAU - Abu Osman, Noor Azuan AU - Abu Osman NA AD - Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia. LA - eng PT - Comparative Study PT - Evaluation Study PT - Journal Article DEP - 20260710 PL - England TA - Proc Inst Mech Eng H JT - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine JID - 8908934 SB - IM MH - Humans MH - *Skin Temperature MH - *Infrared Rays MH - Child MH - Female MH - Male MH - *Thermometers MH - *Thermometry/instrumentation OTO - NOTNLM OT - contact OT - measurement OT - non-contact OT - skin temperature OT - temperature sensor OT - thermometry COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/11 16:11 MHDA- 2026/08/11 06:35 CRDT- 2026/07/11 01:33 PHST- 2026/08/11 06:35 [medline] PHST- 2026/07/11 16:11 [pubmed] PHST- 2026/07/11 01:33 [entrez] AID - 10.1177/09544119261465864 [doi] PST - ppublish SO - Proc Inst Mech Eng H. 2026 Aug;240(8):861-875. doi: 10.1177/09544119261465864. Epub 2026 Jul 10. PMID- 42432712 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260721 LR - 20260813 IS - 1753-2000 (Print) IS - 1753-2000 (Electronic) IS - 1753-2000 (Linking) VI - 20 IP - 1 DP - 2026 Jul 10 TI - Digital media balance and mental health: effects of a school-based program. LID - 10.1186/s13034-026-01131-3 [doi] LID - 95 AB - BACKGROUND: Adolescent mental health problems are rising globally, with problematic digital media use identified as an important risk factor. Universal school-based interventions that integrate Social and Emotional Learning (SEL) with digital balance strategies may promote resilience and reduce risk. This study evaluated On the Inside, a classroom-based SEL and digital balance program. METHODS: A total of 750 students aged 13-15 years from eight schools (two control schools) participated. Surveys were completed at baseline (T1), post-intervention (T2), and, for a subsample, one year later (T3). The program comprised five video-based sessions delivered by teachers. Outcomes included psychological distress (PHQ-4), problematic social media use (GSMQ-9), and adaptive behaviors. Data were analyzed using multilevel mixed models to account for clustering by school. RESULTS: Relative to controls (n = 193), students in the intervention group (n = 557) reported reductions in psychological distress, problematic social media use, multitasking, and avoidance, alongside increased use of adaptive strategies such as distancing phones during study and challenging negative thoughts. Several effects, including reduced distress and avoidance, and sustained strategy use, remained at one-year follow-up. No significant effects were observed for sleep, help-seeking, or breathing strategies. CONCLUSIONS: This universal, teacher-delivered program integrating SEL and digital balance was feasible and produced small but clinically meaningful improvements in adolescent distress and related behaviors, with some effects sustained after one year. These findings support the potential of school-based interventions to address digital media-related risks and promote mental health at a population level. Further research should refine program components, particularly for sleep and screen time, and examine cost-effectiveness to inform broader implementation. CI - (c) 2026. The Author(s). FAU - Guath, Mona AU - Guath M AD - Department of Psychology, Uppsala University, Box 1225, 751 42, Uppsala, Sweden. FAU - Nutley, Sissela B AU - Nutley SB AUID- ORCID: 0000-0002-0676-0380 AD - Department of Clinical Neuroscience, Karolinska Institutet, Nobels vag 9, 171 77, Stockholm, Sweden. sissela.bergman.nutley@ki.se. FAU - Thorell, Lisa B AU - Thorell LB AD - Department of Clinical Neuroscience, Karolinska Institutet, Nobels vag 9, 171 77, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - Child Adolesc Psychiatry Ment Health JT - Child and adolescent psychiatry and mental health JID - 101297974 PMC - PMC13383498 OTO - NOTNLM OT - Adolescence OT - Digital balance OT - Mental health OT - Psychological well-being OT - SEL OT - School-based program COIS- Declarations. Competing interests: MG and LT have no competing interests to report, SN is currently part-time employed by a non-profit distributing the school-program On the Inside/Det syns inte (Swedish name) studied. EDAT- 2026/07/11 05:38 MHDA- 2026/07/11 05:39 PMCR- 2026/07/10 CRDT- 2026/07/10 23:50 PHST- 2025/09/23 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/11 05:39 [medline] PHST- 2026/07/11 05:38 [pubmed] PHST- 2026/07/10 23:50 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.1186/s13034-026-01131-3 [pii] AID - 1131 [pii] AID - 10.1186/s13034-026-01131-3 [doi] PST - epublish SO - Child Adolesc Psychiatry Ment Health. 2026 Jul 10;20(1):95. doi: 10.1186/s13034-026-01131-3. PMID- 42432606 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260911 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Jul 10 TI - Predictive models of adverse outcomes of overweight or obesity: a nationwide cohort validation. LID - 10.1186/s12902-026-02399-4 [doi] LID - 265 AB - BACKGROUND: Obesity and overweight have a wide range of adverse clinical outcomes. Predictive models could help clinicians identify individuals with obesity and overweight at greater risk for obesity-related complications, enabling personalized shared decision-making about obesity treatment. We previously developed a set of predictive models of adverse clinical outcomes of obesity and overweight using electronic health record (EHR) data of a large health system in Massachusetts. However, these models have not been validated on data from other sources. METHODS: We validated 12 predictive models for cardiometabolic, oncologic and musculoskeletal complications of excess weight using a linked EHR and claims dataset of a national patient cohort (Optum((R)) Market Clarity) that included adults 18-80 years of age with body mass index (BMI) >/= 25 kg/m(2) between 2007 and 2023. RESULTS: A 5% randomly selected validation dataset included 437,223 patients (51.9% women) with a mean age of 51.4 years and a mean BMI of 31.9 kg/m(2) who were followed for a mean of 5.7 years. Most (11/12) models achieved Harrell C-index >/= 0.70. Most (11/12) models had either 5-year or 10-year calibration slope within 0.3 of the ideal value of 1.0; 7 out of 12 had either 5-year or 10-year calibration slope that was not significantly different from 1.0; all had intercepts very close to 0. CONCLUSIONS: A set of EHR-based predictive models of adverse outcomes of obesity and overweight was generalizable to a large national cohort. These findings suggest potential clinical and population health applications for predictive models in treatment of individual patients with obesity / overweight, as well as in population management and quality improvement. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Turchin, Alexander AU - Turchin A AUID- ORCID: 0000-0002-8609-564X AD - Brigham and Women's Hospital, Boston, MA, USA. aturchin@bwh.harvard.edu. AD - Harvard Medical School, Boston, MA, USA. aturchin@bwh.harvard.edu. FAU - Shubina, Maria AU - Shubina M AD - Brigham and Women's Hospital, Boston, MA, USA. FAU - Morrison, Fritha J AU - Morrison FJ AD - Brigham and Women's Hospital, Boston, MA, USA. FAU - Ahmad, Nadia N AU - Ahmad NN AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Neff, Lisa M AU - Neff LM AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Kan, Hong AU - Kan H AD - Eli Lilly and Company, Indianapolis, IN, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260710 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 SB - IM MH - Humans MH - Female MH - *Obesity/complications/epidemiology MH - Middle Aged MH - *Overweight/complications/epidemiology MH - Male MH - Aged MH - Adult MH - Body Mass Index MH - Prognosis MH - Aged, 80 and over MH - Young Adult MH - Adolescent MH - Electronic Health Records/statistics & numerical data MH - Prediction Algorithms MH - Cohort Studies MH - Follow-Up Studies PMC - PMC13556077 OTO - NOTNLM OT - Long-term outcomes OT - Obesity OT - Overweight OT - Predictive modeling OT - Validation COIS- Declarations. Ethics approval and consent to participate: This study followed the principles outlined in the Helsinki Declaration. The study was approved by the Mass General Brigham institutional review board (protocol # 2021P003735), and the requirement for informed consent was waived. Consent for publication: Not applicable. Competing interests: Turchin reports consulting for Novo Nordisk and Proteomics International; research and travel support from Eli Lilly and Company; and research support from Novo Nordisk. Ahmad, Neff and Kan are employees and stockholders of Eli Lilly and Company. None of the other authors report any conflicts of interest. EDAT- 2026/07/11 05:37 MHDA- 2026/09/09 07:07 PMCR- 2026/07/10 CRDT- 2026/07/10 23:47 PHST- 2025/05/12 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 23:47 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.1186/s12902-026-02399-4 [pii] AID - 2399 [pii] AID - 10.1186/s12902-026-02399-4 [doi] PST - epublish SO - BMC Endocr Disord. 2026 Jul 10;26(1):265. doi: 10.1186/s12902-026-02399-4. PMID- 42432565 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261016 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jul 10 TI - Exploring the role of non-formal training in an international youth mobility on young adult's perception of appearance and dental aesthetics. LID - 10.1186/s12903-026-09109-5 [doi] LID - 2017 AB - BACKGROUND: Dental aesthetic concerns in young adults are shaped by sociocultural appearance pressures and media-derived ideals, yet education-based interventions targeting these upstream determinants have received limited attention in dentistry. This exploratory study examined whether a brief non-formal educational programme delivered within an Erasmus+ youth mobility context was associated with short-term changes in sociocultural appearance attitudes and the psychosocial impact of dental aesthetics. METHODS: A single-group, quasi-experimental pre-test/post-test design was used. Thirty-four young adults (aged 18-30; 23 from Turkiye, 11 from France) completed the Sociocultural Attitudes Toward Appearance Questionnaire-4 (SATAQ-4) and the Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) immediately before (T0) and immediately after (T1) a five-day programme integrating media literacy, body-positivity activities, and oral health education. Pre-post differences were tested using Wilcoxon signed-rank tests with Holm adjustment, with rank-biserial correlations as effect sizes. Internal consistency was estimated using Cronbach's alpha and McDonald's omega. Reporting followed the TREND and TIDieR guidelines. RESULTS: From T0 to T1, SATAQ-4 total scores decreased (r_rb = - 0.782, 95% CI [- 0.956, - 0.536]) and PIDAQ total scores decreased (r_rb = - 0.655, 95% CI [- 0.882, - 0.345]). All subscales showed changes in the direction anticipated by the study hypothesis, with reductions in negative PIDAQ domains and an increase in Dental Self-Confidence. All comparisons remained significant after Holm adjustment (p_Holm SC(2) (beta = 0.041, p < .001), PA(1) --> SD(2) (beta = 0.018, p < .05), and PA(1) --> MH(2) (beta = -0.023, p < .05). SC(1) --> MH(2) (beta = -0.034, p < .01). MH(1) --> PA(2) (beta = -0.038, p < .001), and SD(1) --> PA(2) (beta = 0.014, p < .05). Indirect effect PA(1) --> SC(2) --> PC(2) was significant (standardized = -0.001; 95% CI [-0.003, -0.001]). Gender group comparison showed no significant differences (Deltachi(2) (5) = 8.10, p = .16). CONCLUSIONS: PA and PC exert reciprocal influences in adolescents, with higher PA predicting improved SC, better SD, and reduced MH, while psychosomatic distress undermines subsequent PA and SC. SC partially mediates PA's protective effects on comorbidity, with equivalent patterns across genders. Interventions combining PA and social-skills training may disrupt the vicious cycle of adolescent PC. CI - (c) 2026 Association for Child and Adolescent Mental Health. FAU - Guo, Xinmeng AU - Guo X AUID- ORCID: 0000-0002-0432-6118 AD - School of Physical Education, Shandong University, Jinan, China. FAU - Yi, Nuo AU - Yi N AD - Physical medicine and rehabilitation, Christus Health, Canton, TX, USA. FAU - Lai, Xinxin AU - Lai X AD - School of Physical Education, Shandong University, Jinan, China. FAU - Yi, Xiangren AU - Yi X AD - School of Physical Education, Shandong University, Jinan, China. FAU - Dong, Xiaosheng AU - Dong X AUID- ORCID: 0000-0003-0507-2938 AD - School of Physical Education, Shandong University, Jinan, China. AD - Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China. AD - NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, China. AD - Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank), Jinan, China. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - J Child Psychol Psychiatry JT - Journal of child psychology and psychiatry, and allied disciplines JID - 0375361 SB - IM OTO - NOTNLM OT - Physical activity OT - adolescents OT - cross-lagged model OT - psychosomatic comorbidity OT - social competence EDAT- 2026/07/11 05:39 MHDA- 2026/07/11 05:39 CRDT- 2026/07/10 23:03 PHST- 2026/06/04 00:00 [accepted] PHST- 2026/07/11 05:39 [medline] PHST- 2026/07/11 05:39 [pubmed] PHST- 2026/07/10 23:03 [entrez] AID - 10.1111/jcpp.70193 [doi] PST - aheadofprint SO - J Child Psychol Psychiatry. 2026 Jul 10. doi: 10.1111/jcpp.70193. PMID- 42431813 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260921 IS - 2352-7226 (Electronic) IS - 2352-7218 (Linking) VI - 12 IP - 5 DP - 2026 Oct TI - Sleep problems and underweight among adolescent girls and adult women aged 12-49 years: A cross-sectional, web-based survey in Japan. PG - 778-785 LID - S2352-7218(26)00127-0 [pii] LID - 10.1016/j.sleh.2026.06.005 [doi] AB - OBJECTIVES: Underweight is a common health concern among individuals of reproductive age. Although sleep and metabolic regulation share neuroendocrine pathways, the relationship between underweight and sleep problems remains unclear. This study aimed to investigate the associations between underweight and questionnaire-based sleep-related outcomes among adolescent girls and adult women. METHODS: These cross-sectional, web-based surveys were conducted from November to December 2023 among adolescent girls (aged 12-18 years) and adult women aged 18 to 49 years. Valid responses were obtained from 996 adolescent girls and 4689 adult women. Logistic regression analyses were conducted within age-defined subgroups to examine associations between weight categories and sleep-related outcomes, including a sleep debt-related pattern with daytime sleepiness and self-reported insomnia symptoms, adjusting for sociodemographic and lifestyle factors. RESULTS: Among respondents, 14.7% of adolescent girls and 23.5% of adult women were underweight. Underweight was not associated with either of the sleep-related outcomes among adolescent girls. In adult women, underweight was associated with self-reported insomnia symptoms in women in their 20s, with no associations observed in other age groups. An interaction between age and underweight was observed, suggesting that this association weakened with increasing age. CONCLUSIONS: Underweight was associated with self-reported insomnia symptoms, but not with a sleep debt-related pattern with daytime sleepiness, among adult women in their 20s. These findings suggest that sleep assessment may be considered as part of comprehensive strategies addressing underweight, although further studies using validated sleep measures are needed. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Kayaba, Momoko AU - Kayaba M AD - International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: momoko.kayaba@gmail.com. FAU - Ogata, Hitomi AU - Ogata H AD - Graduate School of Humanities and Social Sciences, Hiroshima University, Hiroshima, Japan. FAU - Yumen, Yukina AU - Yumen Y AD - Graduate school of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan. FAU - Takayama, Yumi AU - Takayama Y AD - Graduate school of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan. FAU - Kiyono, Ken AU - Kiyono K AD - Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan. FAU - Nose-Ogura, Sayaka AU - Nose-Ogura S AD - Department of Sport Medicine and Research, Japan Institute Sports Sciences, Japan High-Performance Sport Center, kita-ku, Tokyo, Japan. FAU - Nagai, Narumi AU - Nagai N AD - Graduate school of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan. LA - eng PT - Journal Article DEP - 20260711 PL - United States TA - Sleep Health JT - Sleep health JID - 101656808 SB - IM MH - *Sleep Initiation and Maintenance Disorders MH - *Thinness/epidemiology MH - Japan/epidemiology MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Young Adult MH - Adult OTO - NOTNLM OT - Adolescent girls OT - Adult women OT - Reproductive age OT - Sleep OT - Underweight COIS- Declaration of conflicts of interest The authors have declared no conflicts of interest. EDAT- 2026/07/11 05:37 MHDA- 2026/09/17 23:34 CRDT- 2026/07/10 21:53 PHST- 2025/11/06 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/09/17 23:34 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 21:53 [entrez] AID - S2352-7218(26)00127-0 [pii] AID - 10.1016/j.sleh.2026.06.005 [doi] PST - ppublish SO - Sleep Health. 2026 Oct;12(5):778-785. doi: 10.1016/j.sleh.2026.06.005. Epub 2026 Jul 11. PMID- 42431596 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Maternal Intake of Vitamins A, C, D, and E During Pregnancy and Risk of Type 1 Diabetes in the Child: The Norwegian Mother, Father, and Child Cohort Study. PG - 101431 LID - S0002-9165(26)00240-6 [pii] LID - 10.1016/j.ajcnut.2026.101431 [doi] AB - BACKGROUND: Dietary vitamins play a role in antioxidant defense and immunoregulation. However, prospective studies exploring the association between vitamin intakes during pregnancy and the child's risk of type 1 diabetes are limited. OBJECTIVES: This population-based prospective cohort study aimed to investigate the association between maternal intake of vitamins A, C, D, and E during pregnancy and risk of type 1 diabetes in children. METHODS: We included 85,244 children born between 2002 and 2009 in the Norwegian Mother and Child Cohort Study, with follow-up until 31 December, 2021. Maternal intake of vitamins from food and dietary supplements from conception to the 22nd week of pregnancy was assessed with a validated food frequency questionnaire. Cox proportional hazards regression was used to estimate hazard ratios (HRs), adjusting for background factors. RESULTS: During follow-up, 529 (0.6%) children were diagnosed with type 1 diabetes at a mean age of 9.4 y (standard deviation: 4.1 y) No associations were observed between maternal pregnancy intake of vitamin A [HR: 0.993; 95% confidence interval (CI): 0.983, 1.003/100 mug], vitamin C (HR: 1.000; 95% CI: 0.993, 1.007/10 mg), vitamin D (HR: 0.991; 95% CI: 0.978, 1.003/1 mug), or vitamin E (HR: 0.999; 95% CI: 0.996, 1.004/10 mg) and risk of type 1 diabetes in the child when adjusted for potential confounders. The results were similar when intakes were assessed separately from food and dietary supplements and after restriction to children with human leukocyte antigen DQ2 and/or DQ8 risk haplotypes. CONCLUSIONS: This prospective cohort study does not support the hypothesis that higher maternal intake of vitamins A, C, D, and E during pregnancy would decrease risk of type 1 diabetes in the child. Corroborated with previous evidence, our findings support a general pattern of null associations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Mattila, Markus AU - Mattila M AD - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Centre for Child, Adolescent and Maternal Health Research (TamCM), Tampere University, Tampere, Finland. Electronic address: markus.mattila@tuni.fi. FAU - Tapia, German AU - Tapia G AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Stordal, Ketil AU - Stordal K AD - Department of Pediatric Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Brantsaeter, Anne-Lise AU - Brantsaeter AL AD - Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway; Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway. FAU - Virtanen, Suvi M AU - Virtanen SM AD - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Centre for Child, Adolescent and Maternal Health Research (TamCM), Tampere University, Tampere, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland. FAU - Lund-Blix, Nicolai A AU - Lund-Blix NA AD - The Norwegian Childhood Diabetes Registry, Division of Childhood and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Skrivarhaug, Torild AU - Skrivarhaug T AD - Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway; Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway; The Norwegian Childhood Diabetes Registry, Division of Childhood and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Oslo Diabetes Research Centre, Oslo University Hospital, Oslo, Norway. FAU - Hard Af Segerstad, Elin M AU - Hard Af Segerstad EM AD - Pediatric Research Institute, Oslo University Hospital, Oslo, Norway; Unit of Celiac Disease and Diabetes, Clinical Sciences Malmo, Lund University, Malmo, Sweden. FAU - Stene, Lars C AU - Stene LC AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway; Oslo Diabetes Research Centre, Oslo University Hospital, Oslo, Norway. CN - HEDIMED Investigator Group LA - eng PT - Journal Article DEP - 20260710 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Vitamins) RN - 11103-57-4 (Vitamin A) RN - 1406-16-2 (Vitamin D) RN - 1406-18-4 (Vitamin E) RN - PQ6CK8PD0R (Ascorbic Acid) SB - IM MH - Humans MH - Female MH - *Diabetes Mellitus, Type 1/epidemiology/prevention & control MH - Pregnancy MH - Norway/epidemiology MH - Prospective Studies MH - Child MH - Dietary Supplements MH - Male MH - *Vitamins/administration & dosage MH - Vitamin A/administration & dosage MH - Vitamin D/administration & dosage MH - Vitamin E/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - Adult MH - Ascorbic Acid/administration & dosage MH - Cohort Studies MH - Risk Factors OTO - NOTNLM OT - MoBa OT - diabetes mellitus OT - diet OT - dietary supplements OT - observational study OT - pregnancy OT - type 1 OT - vitamins COIS- Conflict of interest The authors report no conflicts of interest. FIR - Kristi, Hoffman IR - Kristi H IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Sara, Javornik Cregeen IR - Sara JC IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Joseph, Petrosino IR - Joseph P IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Tasha, Santiago Rodriguez IR - Tasha SR IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Ondrej, Cinek IR - Ondrej C IRAD- Charles University, 2nd Faculty of Medicine. FIR - Eva, Fronkova IR - Eva F IRAD- Charles University, 2nd Faculty of Medicine. FIR - Hans, Bisgaard IR - Hans B IRAD- COPSAC. FIR - Klaus, Bonnelykke IR - Klaus B IRAD- COPSAC. FIR - Sarah, Brandt IR - Sarah B IRAD- COPSAC. FIR - Astrid, Sevelsted IR - Astrid S IRAD- COPSAC. FIR - Shiraz, Shah IR - Shiraz S IRAD- COPSAC. FIR - Jakob, Stokholm IR - Jakob S IRAD- COPSAC. FIR - Jonathan, Thorsen IR - Jonathan T IRAD- COPSAC. FIR - Jaroslav, Havlik IR - Jaroslav H IRAD- Czech University of Life Sciences Prague, Department of Food Science. FIR - Eliska, Jenickova IR - Eliska J IRAD- Czech University of Life Sciences Prague, Department of Food Science. FIR - Daniel, Schmidtmann IR - Daniel S IRAD- Empirica. FIR - Rainer, Thiel IR - Rainer T IRAD- Empirica. FIR - Leena, Hakola IR - Leena H IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Hannu, Kiviranta IR - Hannu K IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Panu, Rantakokko IR - Panu R IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Suvi M, Virtanen IR - Suvi M V IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Alexander, Berler IR - Alexander B IRAD- Gnomon. FIR - Apostolia, Karabatea IR - Apostolia K IRAD- Gnomon. FIR - Korina, Papadopoulou IR - Korina P IRAD- Gnomon. FIR - Gabriele, Berg IR - Gabriele B IRAD- Graz University of Technology, Institute of Environmental Biotechnology. FIR - Wisnu, Wicaksono IR - Wisnu W IRAD- Graz University of Technology, Institute of Environmental Biotechnology. FIR - Daniel, Agardh IR - Daniel A IRAD- Lund University, Department of Clinical Sciences. FIR - Andren, Aronsson Carin IR - Andren AC IRAD- Lund University, Department of Clinical Sciences. FIR - Markus, Lundgren IR - Markus L IRAD- Lund University, Department of Clinical Sciences. FIR - Bostrom, Michaela IR - Bostrom M IRAD- Lund University, Department of Clinical Sciences. FIR - Marja, Roslund IR - Marja R IRAD- Natural Resources Institute Finland, Horticulture Technologies. FIR - Aki, Sinkkonen IR - Aki S IRAD- Natural Resources Institute Finland, Horticulture Technologies. FIR - Sara, Alibakhshi IR - Sara A IRAD- Satellio. FIR - Lauri, Hame IR - Lauri H IRAD- Satellio. FIR - Patricia-Daiana, Boia IR - Patricia-Daiana B IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Loic, Burr IR - Loic B IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Stefano, Cattaneo IR - Stefano C IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Peter, Cristofollini IR - Peter C IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Silvia, Demuru IR - Silvia D IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Silvia, Generelli IR - Silvia G IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Nicola, Hermann IR - Nicola H IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Hui, Chai-Gao IR - Hui CG IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Samantha, Paoletti IR - Samantha P IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Bradley, Petkus IR - Bradley P IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Edith, Ruth IR - Edith R IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Yevhen, Shynkarenko IR - Yevhen S IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Erika, Antola IR - Erika A IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Anna, Euren IR - Anna E IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Heikki, Hyoty IR - Heikki H IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Nanna, Kangasmaki IR - Nanna K IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Laura, Kivela IR - Laura K IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Kalle, Kurppa IR - Kalle K IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jutta, Laiho IR - Jutta L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Olli, Laitinen IR - Olli L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jussi, Lehtonen IR - Jussi L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jake, Lin IR - Jake L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Katri, Lindfors IR - Katri L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Maria, Lonnrot IR - Maria L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Johannes, Malkamaki IR - Johannes M IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jani, Makinen IR - Jani M IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Henna, Numminen IR - Henna N IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Noora, Nurminen IR - Noora N IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Matti, Nykter IR - Matti N IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Sami, Oikarinen IR - Sami O IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Maarit, Oikarinen IR - Maarit O IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Tiina, Palmu IR - Tiina P IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Leena, Puustinen IR - Leena P IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Niila, Saarinen IR - Niila S IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Erika, Seppala IR - Erika S IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Miia, Siljavaara IR - Miia S IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Amirbabak, Sioofy-Khojine IR - Amirbabak SK IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Minna, Turppa IR - Minna T IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Keijo, Viiri IR - Keijo V IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Mikael, Knip IR - Mikael K IRAD- Tampere University Hospital. FIR - Aleksandr, Peet IR - Aleksandr P IRAD- Tartu University Hospital. FIR - Kart, Simre IR - Kart S IRAD- Tartu University Hospital. FIR - Vallo, Tillmann IR - Vallo T IRAD- Tartu University Hospital. FIR - Elin, Hard Af Segerstad IR - Elin HAS IRAD- The Norwegian Institute of Public Health. FIR - Nicolai A, Lund-Blix IR - Nicolai A LB IRAD- The Norwegian Institute of Public Health. FIR - Maria, Magnus IR - Maria M IRAD- The Norwegian Institute of Public Health. FIR - Aino-Kaisa, Rantala IR - Aino-Kaisa R IRAD- The Norwegian Institute of Public Health. FIR - Lars, Stene IR - Lars S IRAD- The Norwegian Institute of Public Health. FIR - Ketil, Stordal IR - Ketil S IRAD- The Norwegian Institute of Public Health. FIR - German, Tapia IR - German T IRAD- The Norwegian Institute of Public Health. FIR - Iida, Makela IR - Iida M IRAD- University of Helsinki, Faculty of Biological and Environmental Sciences. FIR - Martin, Romantschuk IR - Martin R IRAD- University of Helsinki, Faculty of Biological and Environmental Sciences. FIR - Laura, Soininen IR - Laura S IRAD- University of Helsinki, Faculty of Biological and Environmental Sciences. FIR - Tiia, Honkanen IR - Tiia H IRAD- University of Oulu, Department of Paediatrics. FIR - Juho, Pietila IR - Juho P IRAD- University of Oulu, Department of Paediatrics. FIR - Nelli, Ronka IR - Nelli R IRAD- University of Oulu, Department of Paediatrics. FIR - Toni, Valtanen IR - Toni V IRAD- University of Oulu, Department of Paediatrics. FIR - Riitta, Veijola IR - Riitta V IRAD- University of Oulu, Department of Paediatrics. FIR - Elena, Bargagli IR - Elena B IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Francesco, Dotta IR - Francesco D IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Laura, Nigi IR - Laura N IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Guido, Sebastiani IR - Guido S IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Alar, Aints IR - Alar A IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Kristi, Alnek IR - Kristi A IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Anu, Barenson IR - Anu B IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Anne, Kirss IR - Anne K IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Ivo, Laidmae IR - Ivo L IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Astrid, Oras IR - Astrid O IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Aili, Tagoma IR - Aili T IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Raivo, Uibo IR - Raivo U IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Tamara, Vorobjova IR - Tamara V IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Iltana, Bojovic IR - Iltana B IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Laura, Elo IR - Laura E IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Karoliina, Hirvonen IR - Karoliina H IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Sini, Junttila IR - Sini J IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Jalmari, Kettunen IR - Jalmari K IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Riitta, Lahesmaa IR - Riitta L IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Johanna, Lempainen IR - Johanna L IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Robert, Moulder IR - Robert M IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Omid, Rasool IR - Omid R IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Inna, Starskaia IR - Inna S IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Tomi, Suomi IR - Tomi S IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Jorma, Toppari IR - Jorma T IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Ubaid, Ullah IR - Ubaid U IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Barannik, Emilia IR - Barannik E IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Jean Eudes, Gbodjo Yawogan IR - Jean Eudes GY IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Matthieu, Molinier IR - Matthieu M IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Tarja, Nevanen IR - Tarja N IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Juha, Pajula IR - Juha P IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Juha, Parkka IR - Juha P IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Jukka, Ranta IR - Jukka R IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Jyri, Rokman IR - Jyri R IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Petri, Saviranta IR - Petri S IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Peter, Ylen IR - Peter Y IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Eija, Parmes IR - Eija P IRAD- VTT Technical Research Centre of Finland Ltd. EDAT- 2026/07/11 05:37 MHDA- 2026/09/01 23:34 CRDT- 2026/07/10 19:17 PHST- 2026/03/17 00:00 [received] PHST- 2026/07/04 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 19:17 [entrez] AID - S0002-9165(26)00240-6 [pii] AID - 10.1016/j.ajcnut.2026.101431 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101431. doi: 10.1016/j.ajcnut.2026.101431. Epub 2026 Jul 10. PMID- 42431240 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 227 DP - 2026 Dec 1 TI - Associations between the residential food environment and diet: The Generation R Study. PG - 108717 LID - S0195-6663(26)00279-5 [pii] LID - 10.1016/j.appet.2026.108717 [doi] AB - The neighbourhood food environment is a potentially modifiable determinant of children's diets, yet evidence for associations with dietary outcomes remains mixed. This study examined cross-sectional associations between residential food environment characteristics and dietary outcomes among 8-year-old Dutch children, and whether maternal education (indicating household socioeconomic status) moderated these associations. Data were drawn from (n = 3739) children in the Generation R Study, a population-based birth cohort in Rotterdam, the Netherlands. Residential food environment exposure was assessed using Geographic Information System-based measures of absolute and relative fast-food outlet density and an overall neighbourhood food environment healthiness score within 400m from children's residences. Dietary outcomes were derived from a parent-reported Food Frequency Questionnaire, and included a validated overall diet quality score (out of 10), and non-core food and drink intake (g/day). Associations were examined using generalized linear models, adjusting for potential confounders. Findings revealed limited and unexpected associations. A healthier food environment score was associated with children's poorer diet quality, and no interaction with maternal education was found. Greater absolute fast-food outlet exposure was associated with better diet quality, but only among children with higher-educated mothers (+0.021 point/outlet, 95% CI: 0.008, 0.034). No associations were found between relative fast-food outlet density and any dietary outcomes. No consistent associations were found for food environment exposure and non-core food and drink intake. In the urban Dutch context, neighbourhood food environments showed weak and inconsistent associations with child diet, with some evidence of potential moderation by household socioeconomic status. These findings highlight the need for multidimensional research and intervention strategies that consider family resources and cultural context to effectively support healthy eating among children. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Harris, Holly A AU - Harris HA AD - Erasmus University Rotterdam, Department of Psychology, Education & Child Studies, Rotterdam, the Netherlands; Sydney Nursing School, Faculty of Medicine and Health, Discipline of Nutrition and Dietetics, The University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia. FAU - Molenberg, Famke J M AU - Molenberg FJM AD - Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands. FAU - Jansen, Wilma AU - Jansen W AD - Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands; City of Rotterdam, Department of Social Development, Rotterdam, the Netherlands. FAU - Kocken, Paul AU - Kocken P AD - Erasmus University Rotterdam, Department of Psychology, Education & Child Studies, Rotterdam, the Netherlands. FAU - Voortman, Trudy AU - Voortman T AD - Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands. FAU - Jansen, Pauline W AU - Jansen PW AD - Erasmus University Rotterdam, Department of Psychology, Education & Child Studies, Rotterdam, the Netherlands; Department of Child & Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address: p.w.jansen@erasmusmc.nl. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Netherlands MH - Child MH - Male MH - Cross-Sectional Studies MH - *Residence Characteristics MH - *Diet MH - *Neighborhood Characteristics MH - Fast Foods MH - Educational Status MH - Socioeconomic Factors MH - Surveys and Questionnaires MH - *Diet, Healthy MH - Geographic Information Systems MH - Mothers MH - *Food Supply MH - Feeding Behavior MH - Birth Cohort OTO - NOTNLM OT - Child OT - Diet quality OT - Fast-food exposure OT - Geographic information systems (GIS) OT - Neighbourhood food environment OT - Non-core food OT - Socioeconomic status COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/11 05:37 MHDA- 2026/09/07 23:34 CRDT- 2026/07/10 19:11 PHST- 2025/08/25 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 19:11 [entrez] AID - S0195-6663(26)00279-5 [pii] AID - 10.1016/j.appet.2026.108717 [doi] PST - ppublish SO - Appetite. 2026 Dec 1;227:108717. doi: 10.1016/j.appet.2026.108717. Epub 2026 Jul 10. PMID- 42430813 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 148 IP - 4 DP - 2026 Aug TI - Beyond citrulline: The diagnostic accuracy of amino acid ratios in neonatal intrahepatic cholestasis caused by citrin deficiency. PG - 110201 LID - S1096-7192(26)00484-1 [pii] LID - 10.1016/j.ymgme.2026.110201 [doi] AB - Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is an autosomal recessive metabolic disorder resulting from biallelic pathogenic variants of the SLC25A13 gene. Because NICCD requires immediate and specific dietary management, which differs fundamentally from the treatment of idiopathic neonatal hepatitis (INH), rapid and noninvasive diagnostic tools are crucial. The aim of this study was to systematically evaluate the diagnostic accuracy of amino acid-derived metabolic ratios. This retrospective study analyzed 29 patients with genetically-confirmed NICCD who were evaluated at a single tertiary center between 2011 and 2026. To comprehensively evaluate diagnostic utility, a two-tiered receiver operating characteristic analysis was conducted comparing the NICCD cohort with both a total INH clinical cohort (n = 39) and a genetically-negative INH subgroup (n = 18). The diagnostic performance of amino acid-derived metabolic ratios was comparable to that of individual citrulline levels. The citrulline/alanine and citrulline/tryptophan ratios achieved favorable diagnostic accuracy, maintaining an area under the curve > 0.95, sensitivity > 85%, 100% specificity, and 100% positive predictive value across both control cohorts. The threonine/alanine ratio exceeded the established threonine/serine ratio. Genotype-phenotype analysis indicated that the c.852_855del variant was associated with abnormal newborn screening (p = 0.016), whereas the IVS16ins3kb variant consistently yielded normal results (p = 0.011). The citrulline/alanine, citrulline/tryptophan, and threonine/alanine ratios serve as highly accurate biomarkers that reflect and enhance the detection of the unique metabolic profile of NICCD. Integration of these indices into clinical protocols can reduce the time to diagnosis and facilitate prompt dietary and medical interventions. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Choi, Shinjie AU - Choi S AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. FAU - Choi, Naye AU - Choi N AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. FAU - Kim, Hwa Young AU - Kim HY AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. FAU - Lee, Jisu AU - Lee J AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. FAU - Ko, Jae Sung AU - Ko JS AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. FAU - Ko, Jung Min AU - Ko JM AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea; Rare Disease Center, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: jmko@snu.ac.kr. LA - eng PT - Journal Article DEP - 20260705 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 RN - 29VT07BGDA (Citrulline) RN - 0 (SLC25A13 protein, human) RN - 0 (Mitochondrial Membrane Transport Proteins) RN - 0 (Amino Acids) RN - 1340-08-5 (citrin) RN - 0 (Biomarkers) RN - 0 (Calcium-Binding Proteins) RN - 0 (Organic Anion Transporters) RN - Neonatal-onset citrullinemia type 2 SB - IM MH - Humans MH - *Citrullinemia/diagnosis/genetics/blood/complications MH - *Citrulline/blood/metabolism MH - Female MH - Infant, Newborn MH - Male MH - *Mitochondrial Membrane Transport Proteins/genetics MH - Retrospective Studies MH - *Cholestasis, Intrahepatic/diagnosis/blood/genetics MH - *Amino Acids/blood/metabolism MH - ROC Curve MH - Biomarkers/blood MH - Infant MH - Calcium-Binding Proteins MH - Organic Anion Transporters OTO - NOTNLM OT - Cholestasis, intrahepatic OT - Citrullinemia OT - Neonatal-onset citrullinemia type 2 OT - SLC25A13 protein, human COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/11 01:09 MHDA- 2026/07/16 16:06 CRDT- 2026/07/10 18:00 PHST- 2026/04/05 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/16 16:06 [medline] PHST- 2026/07/11 01:09 [pubmed] PHST- 2026/07/10 18:00 [entrez] AID - S1096-7192(26)00484-1 [pii] AID - 10.1016/j.ymgme.2026.110201 [doi] PST - ppublish SO - Mol Genet Metab. 2026 Aug;148(4):110201. doi: 10.1016/j.ymgme.2026.110201. Epub 2026 Jul 5. PMID- 42430409 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Identification of a HOMA-IR cut-off point for cardiometabolic risk and modifiable risk factors in peruvian adolescents. PG - e0351139 LID - 10.1371/journal.pone.0351139 [doi] LID - e0351139 AB - BACKGROUND: Although HOMA-IR is widely used to assess insulin resistance, reported cut-off values vary substantially across population, particularly during adolescence. The aim of this study was to determine the distribution of HOMA-IR values. identify a HOMA-IR cut-off associated with metabolic syndrome (MS), and assess modifiable risk factors of IR in a longitudinal cohort of Peruvian adolescents. METHODS: We performed a secondary data analysis from a longitudinal adolescent's study. A sample of 371 adolescents (14.5 +/- 0.1 years old) from low- medium socioeconomic status. ROC curve analysis was used to identify the specific cut-off point to classify IR using the sensitivity and specificity values in comparison with the MS. Multiple logistic regression analysis including diet, physical activity and body composition from adolescence, excess weight during infancy and family history of non-chronic disease was included to identify risk factors (FHCD) associated with IR. RESULTS: The HOMA-IR was 3.29 (SD 1.71) with no differences by sex. We identified 3.9 for HOMA-IR as the cut-off point with sensitivity (72.4%) and specificity (75.4%) for predicting MS. IR was present in 28.6% (95% CI 24.2;33.4%); 84% had at least one cardiometabolic risk factor and low HDL and abdominal obesity were the most prevalent (62 and 35%, respectively). Adolescents with higher fat mass index (OR 16.03, 95% CI 6.79 to 37.86), and those physically inactive (OR 2.08 95% CI 1.06 to 4.07) were more likely to have IR. No association was found with diet, excess weight at infancy and FHCD. CONCLUSIONS: A cut-offs point of 3.9 for HOMA-IR allows to identify adolescents with high metabolic risk. Strategies to promote lower FMI and improve the physical activity levels could reduce the risk of IR in adolescents. CI - Copyright: (c) 2026 Curi-Quinto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Curi-Quinto, Katherine AU - Curi-Quinto K AUID- ORCID: 0000-0002-2233-8251 AD - Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. AD - Nutritional Research Institute, Lima, Peru. FAU - Vasquez, Fabian AU - Vasquez F AD - Finis Terrae University, Faculty of Medicine, School of Nutrition and Dietetic, Santiago, Chile. FAU - Abad, Melissa AU - Abad M AD - Nutritional Research Institute, Lima, Peru. FAU - Lazarte, Fabiola AU - Lazarte F AD - Nutritional Research Institute, Lima, Peru. FAU - Penny, Mary AU - Penny M AD - Nutritional Research Institute, Lima, Peru. FAU - Del Valle-Mendoza, Juana AU - Del Valle-Mendoza J AD - Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. AD - Nutritional Research Institute, Lima, Peru. LA - eng PT - Journal Article DEP - 20260710 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Peru/epidemiology MH - Female MH - Adolescent MH - *Insulin Resistance MH - Male MH - *Metabolic Syndrome/epidemiology MH - Risk Factors MH - *Cardiometabolic Risk Factors MH - Longitudinal Studies MH - ROC Curve PMC - PMC13354073 COIS- The authors declare that there are no conflicts of interest. EDAT- 2026/07/11 01:09 MHDA- 2026/07/11 01:10 PMCR- 2026/07/10 CRDT- 2026/07/10 13:53 PHST- 2025/03/06 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/07/11 01:10 [medline] PHST- 2026/07/11 01:09 [pubmed] PHST- 2026/07/10 13:53 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - PONE-D-25-02583 [pii] AID - 10.1371/journal.pone.0351139 [doi] PST - epublish SO - PLoS One. 2026 Jul 10;21(7):e0351139. doi: 10.1371/journal.pone.0351139. eCollection 2026. PMID- 42430426 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Real-world evidence of physical activity practices and policies in Greater London primary schools: A cross-sectional survey. PG - e0352283 LID - 10.1371/journal.pone.0352283 [doi] LID - e0352283 AB - BACKGROUND: The World Health Organization (WHO) recommends six domains for a whole-school approach to promote physical activity (PA) levels. This approach aims to help children achieve 30 of the recommended 60 minutes of daily moderate-to-vigorous physical activity (MVPA). Evidence on PA practice and policy in school settings is limited, particularly in urban areas with high deprivation, where children's PA levels are lowest. METHODS: We developed a 20-item survey based on the WHO domains and distributed it to 1826 state-funded primary schools in all 32 Greater London boroughs between 6 November 2023 and 31 December 2024. We extracted survey items relating to each domain and calculated the percentage of schools reporting each practice. RESULTS: Our sample of 185 schools (10.1%) included at least one school from each borough and was broadly representative of school populations in Greater London, except that responding schools were more likely to have fewer pupils eligible for free school meals. Most schools (68.5%) reported implementing at least one practice aligned with each of the six WHO domains. Specifically, 98.4% reported providing curricular physical education (Domain 1), 78.9% had an active travel plan (Domain 2), 98.4% offered PA opportunities before/after school (Domain 3), 92.4% provided opportunities for PA during breaks (Domain 4), 81.7% incorporated PA into lessons (Domain 5), and 81.5% reported supporting the inclusion of pupils with additional needs in PA opportunities (Domain 6). However, implementation within domains varied; for example, only 53.5% met the nationally recommended two hours of physical education per week, with similarly low levels for before‑school PA provision and active travel initiatives. CONCLUSION: Most primary schools in this large, multi-ethnic urban sample reported school policies and practices aligned with WHO domains, suggesting that a whole-school approach to creating an active school environment is feasible to implement. However, we identified areas for improvement within domains, and alignment alone may be insufficient to meaningfully increase children's PA levels. This study provides a foundation for future research linking active school environments with children's PA and mental health, thereby informing efforts to increase MVPA and promote equitable outcomes. CI - Copyright: (c) 2026 Benkhelfa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Benkhelfa, Amina AU - Benkhelfa A AUID- ORCID: 0009-0007-9006-3222 AD - School of Public Health, Imperial College London, London, United Kingdom. FAU - Ram, Bina AU - Ram B AD - School of Public Health, Imperial College London, London, United Kingdom. FAU - Gullett, Nancy AU - Gullett N AD - School of Public Health, Imperial College London, London, United Kingdom. FAU - Cunningham, Mark AU - Cunningham M AD - School of Public Health, Imperial College London, London, United Kingdom. FAU - Azar Sharabiani, Mansour Taghavi AU - Azar Sharabiani MT AD - School of Public Health, Imperial College London, London, United Kingdom. FAU - Pallan, Miranda AU - Pallan M AD - Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom. FAU - van Sluijs, Esther AU - van Sluijs E AD - IMS Epidemiology, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom. FAU - Summerbell, Carolyn AU - Summerbell C AUID- ORCID: 0000-0003-1910-9383 AD - Department of Sport and Exercise Sciences, Durham University, Durham, United Kingdom. AD - FUSE, the Centre for Translational Research in Public Health, Newcastle University, Newcastle-upon-Tyne, United Kingdom. FAU - Hillsdon, Melvyn AU - Hillsdon M AD - Department of Public Health and Sport Sciences, University of Exeter, Exeter, United Kingdom. FAU - Siddiqui, Nadia AU - Siddiqui N AD - Department of Sport and Exercise Sciences, Durham University, Durham, United Kingdom. AD - Department of Education, Durham University, Durham, United Kingdom. FAU - Saxena, Sonia AU - Saxena S AD - School of Public Health, Imperial College London, London, United Kingdom. LA - eng PT - Journal Article DEP - 20260710 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - London MH - *Schools MH - Humans MH - Cross-Sectional Studies MH - Child MH - *Exercise MH - Surveys and Questionnaires MH - Physical Education and Training MH - Health Promotion PMC - PMC13354065 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/10 18:43 MHDA- 2026/07/10 18:44 PMCR- 2026/07/10 CRDT- 2026/07/10 13:53 PHST- 2025/08/20 00:00 [received] PHST- 2026/06/07 00:00 [accepted] PHST- 2026/07/10 18:44 [medline] PHST- 2026/07/10 18:43 [pubmed] PHST- 2026/07/10 13:53 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - PONE-D-25-39889 [pii] AID - 10.1371/journal.pone.0352283 [doi] PST - epublish SO - PLoS One. 2026 Jul 10;21(7):e0352283. doi: 10.1371/journal.pone.0352283. eCollection 2026. PMID- 42430046 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1475-1313 (Electronic) IS - 0275-5408 (Linking) VI - 46 IP - 5 DP - 2026 Sep TI - Analysis of the Association Between Weight Status and Myopia in Children and Adolescents and Development of a Screening Model Based on Body Fat Percentage. PG - 1040-1048 LID - 10.1007/s44402-026-00135-y [doi] AB - PURPOSE: This study examined the association between weight status and myopia in children and adolescents and compared the screening performance of body mass index (BMI) and body fat percentage. METHODS: This cross-sectional study included 8748 students aged 7-15 years. Height, weight and body fat percentage were measured, and myopia was assessed using non-cycloplegic autorefraction. The sample was randomly divided into training and validation sets. Logistic regression adjusted for sex, age, residence, physical activity and outdoor light exposure was used to examine the association between weight status and myopia. Mediation analysis treated physical activity as a categorical variable, with bootstrap resampling used to test indirect effects through BMI and body fat percentage. Receiver operating characteristic curves compared the screening performance of both indicators. RESULTS: Overweight or obesity was associated with myopia after full adjustment (odds ratio = 1.45, 95% confidence interval: 1.30-1.63). Categorical mediation analysis showed a direct protective association of higher physical activity with myopia, with no significant indirect effect through BMI or body fat percentage. In both training and validation sets, the area under the curve was 0.76 for BMI and 0.76 for body fat percentage. A body fat percentage threshold of 0.69 classified a high-risk group with higher myopia prevalence than the low-risk group (88.7% versus 52.1%). CONCLUSION: Overweight or obesity is independently associated with myopia. BMI and body fat percentage provide comparable, low-cost tools for initial school-based risk stratification, while physical activity may protect against myopia independently of body composition. CI - (c) 2026. The Author(s), under exclusive licence to The College of Optometrists. FAU - Zhao, Deqiang AU - Zhao D AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Xiaoxiao AU - Chen X AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, China. FAU - Zhang, Aoyu AU - Zhang A AD - Tianshi College of Tianjin, School of Medicine, Tianjin, China. FAU - Pan, Xiang AU - Pan X AD - Graduate School of Health and Sports Science, Juntendo University, Inzai, Japan. FAU - Wang, Chunmiao AU - Wang C AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Jiaxin AU - Chen J AD - China Institute of Sport Science, Beijing, China. FAU - Hu, Haixia AU - Hu H AD - Aiyoudong Children and Youth Sports Health Research Institute, Weifang, China. FAU - Zhang, Yanfeng AU - Zhang Y AD - China Institute of Sport Science, Beijing, China. zhangyanfeng0310@126.com. LA - eng GR - 2022YFC3600204/Special Project on "Scientific and Technological Countermeasures for Positive Health and Population Aging" under the National Key Research and Development Program of China/ GR - B2311/Weifang Integration of Sports and Health Innovation and Development Project/ GR - B2422/Weifang Children and Adolescents Sports-Health Integration Innovation and Development Initiative/ PT - Journal Article DEP - 20260710 PL - England TA - Ophthalmic Physiol Opt JT - Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) JID - 8208839 SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Myopia/epidemiology/physiopathology/diagnosis/etiology MH - Cross-Sectional Studies MH - Male MH - Body Mass Index MH - *Adipose Tissue MH - ROC Curve MH - Risk Factors MH - *Overweight/complications MH - Prevalence MH - *Body Weight/physiology OTO - NOTNLM OT - Body fat percentage OT - Children and adolescents OT - Myopia OT - Overweight and obesity OT - ROC curve OT - Screening model COIS- Competing Interests: The authors declare no competing interests. Consent to Publish Declaration: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of the China Institute of Sport Science (Approval No. CISSLA20230110). Written informed consent was obtained from the guardians of all participating children and the children themselves provided assent. Ethics and Consent to Participate Declarations: All guardians of the subjects participating in the study have signed the informed consent form. Institutional Review Board statement: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of the Chinese Institute of Sport Science (No. CISSLA20230110). EDAT- 2026/07/10 12:44 MHDA- 2026/09/04 17:40 CRDT- 2026/07/10 11:20 PHST- 2025/12/18 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/06/18 00:00 [revised] PHST- 2026/09/04 17:40 [medline] PHST- 2026/07/10 12:44 [pubmed] PHST- 2026/07/10 11:20 [entrez] AID - 10.1007/s44402-026-00135-y [pii] AID - 10.1007/s44402-026-00135-y [doi] PST - ppublish SO - Ophthalmic Physiol Opt. 2026 Sep;46(5):1040-1048. doi: 10.1007/s44402-026-00135-y. Epub 2026 Jul 10. PMID- 42429973 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 10 TI - A multivariate electrocardiographic predictive model for left ventricular hypertrophy in children with primary hypertension. LID - 569 [pii] LID - 10.1007/s00431-026-07198-6 [doi] AB - Current electrocardiographic (ECG) criteria are of low diagnostic value compared with echocardiography (ECHO) for LVH, establishing a more effective ECG predictive model is required. The research purpose was to establish and validate a model to improve the diagnostic capability of ECG for LVH in pediatric primary hypertension. A retrospective study of 502 hypertensive children were recruited in the study between January 2019 and December 2024. The cohort were randomly divided into training (n = 402) and test sets (n = 100) with a proportion of 8:2. LVH was diagnosed using ECHO criteria. A total of 22 ECG parameters were evaluated. A predictive nomogram was developed using least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression. LVH was identified in 117 (29.1%) of the training set and 29 (29.0%) of the test set. Body mass index (BMI), R(I) + S(V4), and S(D) + S(V4) were identified as independent predictors of LVH. The nomogram model showed good performance, with an area under the curve (AUC) of 0.822 in the training set and 0.803 in the test set. Calibration curves and Hosmer-Lemeshow test indicated good agreement between predicted and actual probabilities. DCA demonstrated clinical usefulness. The model outperformed previous models, as confirmed by NRI and IDI. CONCLUSIONS: The nomogram model incorporating BMI, R(I) + S(V4), and S(D) + S(V4) significantly improves the ECG diagnosis of LVH in pediatric primary hypertension, serving as a reliable tool for early LVH detection in hypertensive children. WHAT IS KNOWN: * We established a pediatric-specific nomogram integrating BMI and two composite ECG indices (R(I) + S(V4), S(D) + S(V4)); this model outperforms conventional adult ECG criteria and exhibits reliable discrimination, calibration and clinical practicability for diagnosing LVH in children with primary hypertension diagnosing LVH in children with primary hypertension. * This work innovatively uses BMI as a correction term to compensate for ECG voltage attenuation induced by chest wall fat in obese children, substantially lifting the overall ECG diagnostic accuracy of pediatric hypertensive LVH. WHAT IS NEW: * Our current study developed a nomogram model combining BMI, RI + SV4, and SD + SV4 that significantly improves ECG diagnostic accuracy for LVH in children with primary hypertension. * The research innovatively transforms BMI into a corrective factor addressing voltage attenuation caused by chest wall fat in obese children. * The model identifies pediatric-specific composite ECG indices superior to adult-derived criteria, demonstrating good discrimination, calibration, and clinical utility. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Liu, Yang AU - Liu Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Cui, Yaxi AU - Cui Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Lin, Yao AU - Lin Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Zheng, Tong AU - Zheng T AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Bao, Min AU - Bao M AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Liu, Yanyan AU - Liu Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Jiang, He AU - Jiang H AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Shi, Lin AU - Shi L AUID- ORCID: 0000-0001-7578-7440 AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. shilin9789@126.com. LA - eng GR - YJRC202401/Research Start-up Fund for Introduced Talents of Capital Institute of Pediatrics/ GR - YGLX202532/Beijing Hospitals Authority Clinical medicine Development of special funding support/ GR - XZYB-2025-01/New Quality Fund of Capital Institute of Pediatrics/ PT - Journal Article DEP - 20260710 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Electrocardiography/methods MH - *Hypertrophy, Left Ventricular/diagnosis/etiology MH - Retrospective Studies MH - Child MH - *Nomograms MH - Female MH - Male MH - Predictive Value of Tests MH - *Essential Hypertension/complications MH - Adolescent MH - Multivariate Analysis MH - *Hypertension/complications MH - Echocardiography MH - Logistic Models OTO - NOTNLM OT - Children OT - Echocardiography OT - Electrocardiography OT - Hypertension OT - Left ventricular hypertrophy OT - Predictive model COIS- Declarations. Ethics approval: This study had approval from the Ethic Committee of the Capital Center for Children's Health, Capital Medical University (No: SHERLL2025011). Each child's parent or legal guardian/next of kin provided signed informed consent. This study was performed in line with the principles of the Declaration of Helsinki and its later amendments. Consent to participate: All participants gave their written consent to participate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/10 12:46 MHDA- 2026/07/11 01:09 CRDT- 2026/07/10 11:15 PHST- 2026/03/19 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/05/29 00:00 [revised] PHST- 2026/07/11 01:09 [medline] PHST- 2026/07/10 12:46 [pubmed] PHST- 2026/07/10 11:15 [entrez] AID - 10.1007/s00431-026-07198-6 [pii] AID - 10.1007/s00431-026-07198-6 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 10;185(8):569. doi: 10.1007/s00431-026-07198-6. PMID- 42429723 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260826 IS - 2405-5018 (Electronic) IS - 2405-500X (Print) IS - 2405-500X (Linking) VI - 12 IP - 8 DP - 2026 Aug TI - Beta-Blockers and Exercise Performance in Children With Long QT Syndrome. PG - 2010-2018 LID - S2405-500X(26)00558-X [pii] LID - 10.1016/j.jacep.2026.06.010 [doi] AB - BACKGROUND: Young people taking beta-blockers for long QT syndrome (LQTS) have concerns about exercise performance. OBJECTIVES: This study sought to determine whether objective measures of cardiopulmonary fitness are influenced by beta-blocker dose in LQTS. METHODS: In a retrospective chart review of treadmill cardiopulmonary exercise tests (CPETs), we measured peak oxygen consumption (Vo(2)), respiratory exchange ratio (RER), blood pressure, and percent predicted heart rate at peak exertion (%PHR), each analyzed with a linear mixed-effects model. We analyzed nadolol data (noncardioselective) as our primary analysis, then analyzed a validation cohort of atenolol data (cardioselective). RESULTS: We evaluated 220 CPETs in 93 patients with LQTS. The mean age at first CPET was 12 +/- 3.9 years. In multivariable analysis, %PHR decreased by 13% for every 1 mg/kg/d increase in beta-blocker dose, demonstrating physiologic beta-blocker effects. However, we identified no correlation between nadolol dose and measures of cardiopulmonary fitness. Neither peak Vo(2) nor peak RER was correlated with nadolol dose. Only mild blood pressure changes were observed (<9 mm Hg decrease at peak exertion per 1 mg/kg increase in nadolol dose). Increased atenolol dose was also associated with stable peak Vo(2) and peak RER. CONCLUSIONS: In children with LQTS, we did not observe any relationship between higher nadolol doses and objective measures of effort (peak RER) or cardiopulmonary fitness (peak Vo(2)), despite a linear dose-response between nadolol dose and %PHR. These results suggest that treatment with nadolol for LQTS does not affect most patients' peak exercise performance. These data were validated in patients from an earlier era who had been prescribed atenolol. CI - Copyright (c) 2026 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Webster, Gregory AU - Webster G AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address: rgwebster@luriechildrens.org. FAU - Gill, Nathan AU - Gill N AD - Division of Biostatistics and Informatics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Carberry, Thomas AU - Carberry T AD - Corewell Health Helen Devos Children's Hospital, Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA. FAU - Chandler, Stephanie F AU - Chandler SF AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Cherny, Sara AU - Cherny S AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Lockhart, Elli N AU - Lockhart EN AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Onorato, Angela C AU - Onorato AC AD - The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA. FAU - Dillenbeck, Halley AU - Dillenbeck H AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Ward, Kendra AU - Ward K AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Laternser, Christina AU - Laternser C AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. LA - eng GR - R01 HL164773/HL/NHLBI NIH HHS/United States GR - UL1 TR001422/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260709 PL - United States TA - JACC Clin Electrophysiol JT - JACC. Clinical electrophysiology JID - 101656995 RN - 0 (Adrenergic beta-Antagonists) RN - 50VV3VW0TI (Atenolol) RN - 42200-33-9 (Nadolol) SB - IM MH - Humans MH - Child MH - *Long QT Syndrome/drug therapy/physiopathology MH - Exercise Test MH - *Adrenergic beta-Antagonists/therapeutic use/pharmacology MH - Female MH - Retrospective Studies MH - Adolescent MH - Male MH - Atenolol/therapeutic use MH - Heart Rate/drug effects MH - Oxygen Consumption/drug effects MH - Nadolol/therapeutic use/pharmacology MH - Blood Pressure/drug effects MH - *Exercise/physiology MH - Cardiorespiratory Fitness/physiology PMC - PMC13502152 MID - NIHMS2192871 OTO - NOTNLM OT - beta-adrenergic receptor antagonist OT - cardiopulmonary exercise test OT - electrophysiology OT - long QT syndrome OT - pediatric OT - pharmacology COIS- Funding Support and Author Disclosures The Northwestern University Clinical and Translational Sciences Institute is funded in part by a Clinical and Translational Science Award grant from the National Institutes of Health (UL1TR001422). This study was supported, in part, by the National Institutes of Health/National Heart, Lung, and Blood Institute (R01 HL164773) and philanthropic donors. Dr Webster has served as a consultant for Solid Biosciences. Dr Ward has served as a site principal investigator for a trial funded by Mezzion Pharmaceuticals. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. EDAT- 2026/07/10 12:46 MHDA- 2026/08/25 11:38 PMCR- 2026/08/25 CRDT- 2026/07/10 10:27 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/25 11:38 [medline] PHST- 2026/07/10 12:46 [pubmed] PHST- 2026/07/10 10:27 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - S2405-500X(26)00558-X [pii] AID - 10.1016/j.jacep.2026.06.010 [doi] PST - ppublish SO - JACC Clin Electrophysiol. 2026 Aug;12(8):2010-2018. doi: 10.1016/j.jacep.2026.06.010. Epub 2026 Jul 9. PMID- 42429700 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260821 IS - 1879-1972 (Electronic) IS - 1054-139X (Print) IS - 1054-139X (Linking) VI - 79 IP - 3 DP - 2026 Sep TI - Cultural Food Practices and Their Potential Role in Mitigating Disordered Eating Among American Indian/First Nations Youth. PG - 404-411 LID - S1054-139X(26)00191-6 [pii] LID - 10.1016/j.jadohealth.2026.05.006 [doi] AB - PURPOSE: Explore the relationship between disordered eating and engagement in cultural food practices in a sample of American Indian/First Nations (AI/FNs) adolescents. METHODS: Using interviewer-administered surveys data derived from Healing Pathways (N = 661), a longitudinal community-based participatory research study with Midwest AI/FN communities, we examined disordered eating, cultural food practices, and related sociodemographic variables in AI/FN adolescents using data from two time points/waves of this larger longitudinal study. We examined the structure of a disordered eating questionnaire using exploratory factor analysis to reveal psychometric properties of the questionnaire, resulting in three distinct disordered eating constructs "binge eating," "obsessive food behaviors," and "altered feelings about body." Associations with cultural food practices and these disordered eating constructs were examined using adjusted and unadjusted linear regression models. RESULTS: Greater engagement in cultural food practices was significantly associated with lower levels of "altered feelings about body" in both unadjusted (beta = -0.27, standard error [SE] = 0.04, p < .001) and adjusted models (beta = -0.11, SE = 0.05, p < .05). Identifying as female was linked to higher levels of both "obsessive food behaviors" (adjusted beta = 0.36, SE = 0.12, p < .05) and "altered feelings about body" (adjusted beta = 1.65, SE = 0.16, p < .001). DISCUSSION: Participation in cultural food practices may potentially play an important role in creating and sustaining healthy eating behaviors for AI/FN youth. Future research should consider the impact of disordered eating on nutrition-related health behaviors, as well as the potential protective role of cultural food practices against unhealthy eating behaviors. CI - Copyright (c) 2026 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved. FAU - Maudrie, Tara L AU - Maudrie TL AD - University of Michigan, School of Social Work, Ann Arbor, Michigan; Department of Health Behavior & Health Equity, University of Michigan, School of Public Health, Ann Arbor, Michigan. FAU - Gillson, Stefanie AU - Gillson S AD - Yale School of Medicine, Child Study Center, New Haven, Connecticut. FAU - Anderson, Olivia AU - Anderson O AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Walls, Melissa L AU - Walls ML AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Center for Indigenous Health, Great Lakes Hub, Duluth, Minnesota. FAU - Steinberg, Rachel AU - Steinberg R AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Center for Indigenous Health, Great Lakes Hub, Duluth, Minnesota. FAU - Williams, Stephanie AU - Williams S AD - Healing Pathways, Community Research Council, Duluth, Minnesota. FAU - Hautala, Dane AU - Hautala D AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Center for Indigenous Health, Great Lakes Hub, Duluth, Minnesota. LA - eng GR - R01 DA039912/DA/NIDA NIH HHS/United States GR - U54 CA280805/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260710 PL - United States TA - J Adolesc Health JT - The Journal of adolescent health : official publication of the Society for Adolescent Medicine JID - 9102136 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Community-Based Participatory Research MH - *Feeding and Eating Disorders/ethnology/prevention & control/psychology MH - *Feeding Behavior/ethnology/psychology MH - *Indians, North American/psychology MH - Longitudinal Studies MH - Surveys and Questionnaires MH - *Indigenous Canadians/psychology PMC - PMC13488913 MID - NIHMS2201366 OTO - NOTNLM OT - AI/AN OT - Disordered eating OT - Food sovereignty OT - Indigenous OT - Nutrition OT - Traditional foods COIS- Conflicts of interest: The authors report no conflicts of interest. EDAT- 2026/07/10 12:45 MHDA- 2026/08/04 00:35 PMCR- 2026/08/19 CRDT- 2026/07/10 10:27 PHST- 2025/12/15 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/07/10 12:45 [pubmed] PHST- 2026/07/10 10:27 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - S1054-139X(26)00191-6 [pii] AID - 10.1016/j.jadohealth.2026.05.006 [doi] PST - ppublish SO - J Adolesc Health. 2026 Sep;79(3):404-411. doi: 10.1016/j.jadohealth.2026.05.006. Epub 2026 Jul 10. PMID- 42429469 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 96 IP - 8 DP - 2026 Aug TI - Alternative Breakfast Service Models Are Associated With Greater Student School Breakfast Participation: Evidence From Middle and High School Students Across 8 States. PG - e70192 LID - 10.1111/josh.70192 [doi] LID - e70192 AB - BACKGROUND: Eating school breakfast has benefits for students, yet participation remains lower than that of school lunch. This study examined associations between school breakfast service models, self-reported participation, and perceived participation barriers, and whether these associations differed by school level (middle vs. high) and universal school meals policy (with vs. without). METHODS: One thousand ninety-seven middle and high school students were surveyed. Data were analyzed using multilevel logistic regression. RESULTS: Most students (67%) reported access only to traditional before-school breakfast. Higher odds of participation and lower odds of time-related barriers were found for breakfast in the classroom (OR 3.88; 95% CI 2.49, 6.03) and "second chance" breakfast (OR 2.07; 95% CI 1.43, 3.00) compared to traditional before-school breakfast only. Grab-and-go options were associated with modestly higher odds of participation (OR 1.29; 95% CI 1.01, 1.67) and fewer barriers among high school students. IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: Breakfast after the bell approaches is associated with higher participation and fewer barriers. These strategies can help ensure more students have reliable access to school breakfast. CONCLUSIONS: Alternative school breakfast service models, particularly breakfast in the classroom and "second chance" breakfast, may increase participation and support student nutrition, health, and academic performance. CI - (c) 2026 The Author(s). Journal of School Health published by Wiley Periodicals LLC on behalf of American School Health Association. FAU - Zuercher, Monica D AU - Zuercher MD AUID- ORCID: 0000-0003-2758-9807 AD - Nutrition Policy Institute, University of California Agriculture and Natural Resources, Oakland, California, USA. FAU - Orta-Aleman, Dania AU - Orta-Aleman D AUID- ORCID: 0000-0001-8581-8714 AD - Nutrition Policy Institute, University of California Agriculture and Natural Resources, Oakland, California, USA. FAU - French, Cailin D AU - French CD AD - Nutrition Policy Institute, University of California Agriculture and Natural Resources, Oakland, California, USA. FAU - Hecht, Chrisina A AU - Hecht CA AD - Nutrition Policy Institute, University of California Agriculture and Natural Resources, Oakland, California, USA. FAU - Hecht, Kenneth AU - Hecht K AD - Nutrition Policy Institute, University of California Agriculture and Natural Resources, Oakland, California, USA. FAU - Cohen, Juliana F W AU - Cohen JFW AD - Center for Health Inclusion, Research and Practice, Merrimack College, North Andover, Massachusetts, USA. AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. FAU - Ohri-Vachaspati, Punam AU - Ohri-Vachaspati P AD - College of Health Solutions, Arizona State University, Phoenix, Arizona, USA. FAU - Patel, Anisha I AU - Patel AI AD - Stanford Pediatrics, Stanford University, Palo Alto, California, USA. FAU - Ritchie, Lorrene D AU - Ritchie LD AUID- ORCID: 0000-0002-8038-1821 AD - Nutrition Policy Institute, University of California Agriculture and Natural Resources, Oakland, California, USA. FAU - Gosliner, Wendi AU - Gosliner W AD - Nutrition Policy Institute, University of California Agriculture and Natural Resources, Oakland, California, USA. LA - eng GR - California General Fund Senate Bill/ PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - *Breakfast MH - *Food Services/statistics & numerical data/organization & administration MH - Adolescent MH - Female MH - *Schools/organization & administration MH - *Students/statistics & numerical data/psychology MH - Male MH - United States MH - Child PMC - PMC13353132 OTO - NOTNLM OT - School Breakfast Program OT - alternative school breakfast models OT - child nutrition OT - universal school meals COIS- The authors declare no conflicts of interest. EDAT- 2026/07/10 12:45 MHDA- 2026/07/10 18:43 PMCR- 2026/07/10 CRDT- 2026/07/10 09:32 PHST- 2026/05/21 00:00 [revised] PHST- 2025/10/23 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/10 18:43 [medline] PHST- 2026/07/10 12:45 [pubmed] PHST- 2026/07/10 09:32 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - JOSH70192 [pii] AID - 10.1111/josh.70192 [doi] PST - ppublish SO - J Sch Health. 2026 Aug;96(8):e70192. doi: 10.1111/josh.70192. PMID- 42428268 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Association between triglyceride-glucose body mass index and risk of hypertensive disorders of pregnancy: a case-control study. PG - 1844562 LID - 10.3389/fmed.2026.1844562 [doi] LID - 1844562 AB - OBJECTIVE: To investigate the association between triglyceride-glucose body mass index (TyG-BMI) and the risk of hypertensive disorders of pregnancy (HDP), and to compare the discriminative ability of TyG-BMI with triglyceride-glucose index (TyG) and body mass index (BMI) for HDP. METHODS: A case-control study was conducted including 346 pregnant women hospitalized in the Department of Obstetrics at Fuyang Women and Children's Hospital from January 2021 to December 2025. Participants were divided into HDP group (n = 168) and control group (n = 178) based on HDP diagnosis. General clinical data, physical examinations, and hematological parameters at admission were collected for both groups. BMI, TyG index, and TyG-BMI were calculated. Multivariable logistic regression was used to analyze the independent association between TyG-BMI and HDP. Restricted cubic spline (RCS) curves were employed to explore dose-response relationships. Receiver operating characteristic (ROC) curves were used to compare the discriminative performance of different indices. RESULTS: The TyG-BMI level in the HDP group was significantly higher than that in the control group (228.4 +/- 44.6 vs. 196.8 +/- 36.2, P < 0.001). Multivariable logistic regression analysis showed that after adjusting for confounding factors, each 10-unit increase in TyG-BMI was associated with a 30% increase in HDP risk (adjusted OR = 1.30, 95%CI: 1.16-1.46, P < 0.001). RCS analysis demonstrated a non-linear positive association between TyG-BMI and HDP risk (P for non-linearity = 0.026). ROC analysis revealed that the area under the curve (AUC) for TyG-BMI in discriminating HDP was 0.782 (95%CI: 0.734-0.830), which was significantly superior to TyG index (AUC = 0.708, P = 0.005) and BMI (AUC = 0.694, P < 0.001). Subgroup analysis showed that the association between TyG-BMI and HDP remained consistent across all subgroups (all P for interaction > 0.05). CONCLUSION: TyG-BMI is independently and positively associated with HDP, and its discriminative performance is superior to TyG index and BMI. It can serve as a comprehensive indicator for identifying and assessing the degree of metabolic abnormalities in HDP patients. CI - Copyright (c) 2026 Liu, Ma, Chen and Chang. FAU - Liu, Jun AU - Liu J AD - Department of Obstetrics, Fuyang Women's and Children's Hospital, Fuyang, Anhui, China. FAU - Ma, Haoran AU - Ma H AD - Department of Respiratory and Critical Care Medicine, Fuyang Women's and Children's Hospital, Fuyang, Anhui, China. FAU - Chen, Xi AU - Chen X AD - Department of Ultrasound, Fuyang Women's and Children's Hospital, Fuyang, Anhui, China. FAU - Chang, Xueyun AU - Chang X AD - Department of Obstetrics, Fuyang Women's and Children's Hospital, Fuyang, Anhui, China. LA - eng PT - Journal Article DEP - 20260625 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13346169 OTO - NOTNLM OT - case-control study OT - hypertensive disorders of pregnancy OT - insulin resistance OT - obesity OT - triglyceride-glucose body mass index COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/10 06:35 MHDA- 2026/07/10 06:36 PMCR- 2026/06/25 CRDT- 2026/07/10 05:15 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/10 06:36 [medline] PHST- 2026/07/10 06:35 [pubmed] PHST- 2026/07/10 05:15 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.3389/fmed.2026.1844562 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Jun 25;13:1844562. doi: 10.3389/fmed.2026.1844562. eCollection 2026. PMID- 42427950 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - The association between social media use and dietary intake among adolescents in Turkiye: a cross sectional study. PG - 1862690 LID - 10.3389/fped.2026.1862690 [doi] LID - 1862690 AB - INTRODUCTION: Social media usage has surged up among adolescents and its relationship with dietary intake is unclear. This paper investigated the association between social media use and dietary intake among adolescents in Turkiye. METHODS: A cross sectional study was conducted. Convenience sampling was chosen. Private schools located in two cities in the Central and Eastern regions of Turkiye (Sanliurfa and Karaman). The sample consisted of 251 adolescents (13-18 years of age) and 49% of them were male. Dietary data were collected using a validated food frequency questionnaire. The multiple regression analysis adjusted for age groups were used to assess the relationship between social media use and dietary intake. Then Benjamini-Hochberg FDR correction was applied. All the data are based on beta (unstandardized) with standard error (SE) (beta+/-SE). RESULTS: Fewer than half of the participants reported using social media for over three hours daily (47.4%). The late adolescents used social media more than three hours a day (p < 0.05). Prolonged social media use (>3 h) was associated with higher energy (beta = 356.21 +/- 111.91 kcal, p = 0.002), carbohydrate (beta = 41.19 +/- 14.82 g, p = 0.006), sucrose (beta = 10.75 +/- 3.24 g, p = 0.001), fat (beta = 16.51 +/- 5.83 g, p = 0.005), calcium (beta= 146.44 +/- 54.72 mg, p = 0.008) and zinc (beta = 2.16 +/- 0.75 mg, p = 0.004) intake. Participants who were on social media for more than three hours a day consumed an average of 87.91 g more milk and yoghurt, 27.92 g more meat and processed meat, and 34.38 g more pastry than those who were on social media less than three hours a day. However after Benjamini-Hochberg False Discovery Rate correction, no relationship was found between dairy, meat and pastry consumption with social media duration (p > 0.05). Spending more time on social media was also related to more added sugar consumption (beta = 9.23 +/- 3.38 g, p = 0.007). CONCLUSIONS: The results indicate that prolonged use of social media is associated with higher energy, fat, sucrose, zinc and calcium consumption. These adolescents have a diet richer in micronutrients but also they follow a more obesogenic dietary pattern, which may be related to an increased risk of inflammatory and chronic diseases later in life. Longitudinal studies are needed to determine a causal relationship. CI - (c) 2026 Ozturk. FAU - Ozturk, Meryem Elif AU - Ozturk ME AD - Department of Nutrition and Dietetics, Karamanoglu Mehmetbey University, Karaman, Turkiye. LA - eng PT - Journal Article DEP - 20260625 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13345838 OTO - NOTNLM OT - adolescents OT - dietary intake OT - energy intake OT - social media OT - sucrose COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/10 06:34 MHDA- 2026/07/10 06:35 PMCR- 2026/06/25 CRDT- 2026/07/10 05:11 PHST- 2026/04/22 00:00 [received] PHST- 2026/06/03 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/10 06:35 [medline] PHST- 2026/07/10 06:34 [pubmed] PHST- 2026/07/10 05:11 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1862690 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 25;14:1862690. doi: 10.3389/fped.2026.1862690. eCollection 2026. PMID- 42427907 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260710 LR - 20260813 IS - 2038-9922 (Print) IS - 2038-9930 (Electronic) IS - 2038-9922 (Linking) VI - 17 IP - 1 DP - 2026 TI - Implementation of a Banana Flour Porridge Supplementation Initiative in a Mozambican Primary School: A pilot descriptive study. PG - 1749 LID - 10.4102/jphia.v17i1.1749 [doi] LID - 1749 AB - BACKGROUND: Child malnutrition remains a significant public health challenge in Mozambique, particularly in food-insecure rural communities. Locally available and culturally accepted foods may contribute to strengthening school feeding strategies. AIM: This pilot study described the nutritional status of schoolchildren in a Banana Flour Porridge Supplementation Initiative and assessed the feasibility of implementing and monitoring it in a public-school setting. SETTING: This study was conducted in a rural primary school in Ka Tembe District, Maputo Province, Mozambique. METHODS: A descriptive pilot study was conducted among 65 children aged 6-14 years. All participants received banana flour porridge daily for 30 days. Anthropometric measurements (weight, height, body mass index [BMI]) were collected at baseline, day 15 and day 30. A structured questionnaire assessed dietary habits. Data were analysed using descriptive statistics. RESULTS: At baseline, most children had adequate nutritional status, with low consumption of dairy and fortified foods, suggesting potential micronutrient gaps. During the 30-day supplementation period, the proportion of children classified as having an adequate BMI increased from 62.5% to 84.4% (aged 6-9 years) and from 57.6% to 87.9% (aged 10-14 years). These are descriptive observations. No adverse effects were reported. The initiative was easily integrated into the school routine and well accepted by students. CONCLUSION: Banana flour porridge supplementation is operationally feasible and acceptable in a school setting. Findings should be interpreted as preliminary and hypothesis-generating. CONTRIBUTION: This pilot provides early insights into the feasibility and acceptability of incorporating banana flour porridge into school feeding programmes. CI - (c) 2026. The Authors. FAU - Chidassicua, Jose Braz AU - Chidassicua JB AUID- ORCID: 0000-0001-5131-0349 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, National Institute of Health, Maputo, Mozambique. FAU - Titosse, Antonio AU - Titosse A AUID- ORCID: 0000-0001-6154-1933 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, Maputo, Mozambique. FAU - Magaco, Amilcar AU - Magaco A AUID- ORCID: 0000-0002-6381-4576 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. FAU - Mondlane, Reginalda AU - Mondlane R AUID- ORCID: 0009-0008-0005-7740 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, Maputo, Mozambique. FAU - Mambuque, Edson AU - Mambuque E AUID- ORCID: 0000-0002-9106-1444 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Manhica Health Research Center (CISM), Manhica, Mozambique. FAU - Goncalves, Maria Patricia AU - Goncalves MP AUID- ORCID: 0009-0002-5573-2842 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, National Institute of Health, Maputo, Mozambique. FAU - Cane, Reka Maulide AU - Cane RM AUID- ORCID: 0000-0001-8209-4976 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, National Institute of Health, Maputo, Mozambique. LA - eng PT - Journal Article DEP - 20260608 PL - South Africa TA - J Public Health Afr JT - Journal of public health in Africa JID - 101586943 PMC - PMC13347745 OTO - NOTNLM OT - Mozambique OT - child nutrition OT - food security OT - pilot study OT - school feeding OT - schoolchildren OT - sub-Saharan Africa COIS- The authors reported that they received funding from the Sergio Gago Foundation, which may be affected by the research reported in the enclosed publication. The authors have disclosed those interests fully and have implemented an approved plan for managing any potential conflicts arising from their involvement. The terms of these funding arrangements have been reviewed and approved by the affiliated institution in accordance with its policy on objectivity in research. EDAT- 2026/07/10 06:35 MHDA- 2026/07/10 06:36 PMCR- 2026/06/08 CRDT- 2026/07/10 05:11 PHST- 2025/11/03 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/07/10 06:36 [medline] PHST- 2026/07/10 06:35 [pubmed] PHST- 2026/07/10 05:11 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - JPHIA-17-1749 [pii] AID - 10.4102/jphia.v17i1.1749 [doi] PST - epublish SO - J Public Health Afr. 2026 Jun 8;17(1):1749. doi: 10.4102/jphia.v17i1.1749. eCollection 2026. PMID- 42426960 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1365-2982 (Electronic) IS - 1350-1925 (Print) IS - 1350-1925 (Linking) VI - 38 IP - 7 DP - 2026 Jul TI - Transitioning Adolescents and Young Adults With Neurogastroenterology and Motility Disorders to Adult Care. Current Practices and Challenges in North America. PG - e70394 LID - 10.1111/nmo.70394 [doi] LID - e70394 AB - BACKGROUND: Pediatric neurogastroenterology and motility (NGM) disorders frequently persist into adulthood, yet there are no standardized transition of care (TOC) practices for this patient population. We characterized current TOC practices for adolescents and young adults with NGM disorders across North America. METHODS: A survey was distributed through listservs for North American pediatric gastroenterologists, registered dietitians, and advanced practice providers. The survey assessed institutional characteristics, TOC practices, team structure, handoff practices, barriers, and unmet needs. KEY RESULTS: Sixty-nine respondents from 40 unique medical centers completed the survey. Most practiced at academic medical centers (75.5%), with 66% having adult NGM providers at their institution. The majority transitioned patients at ages 18-19 years (44.1%) using patient interviews to assess readiness (61.8%), while only 2.9% used validated assessment tools. Most patients transferred to adult general gastroenterologists (76.5%) or adult NGM experts (64.7%). Infrastructure gaps were identified: 88.2% lacked transition coordinators, 91.3% had no formal transition teams, and no centers received financial support for transition services. Significant barriers reported were need for more adult NGM clinicians (60.3%) and patient hesitancy with transitioning care (58.3%). Respondents identified the greatest needs as more adult NGM clinicians, having dedicated transition coordinators, and formal transition protocols. CONCLUSIONS: This first national survey of NGM transition practices reveals gaps in infrastructure, workforce, and standardized protocols. Addressing these deficiencies requires coordinated efforts between pediatric and adult NGM communities and healthcare institutions to establish evidence-based practices that ensure continuity of care for this vulnerable patient population. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Wolfson, Sharon AU - Wolfson S AUID- ORCID: 0009-0001-9085-1022 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Santucci, Neha AU - Santucci N AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. FAU - Ambartsumayan, Lusine AU - Ambartsumayan L AD - Division of Pediatric Gastroenterology and Nutrition, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA. FAU - Patel, Dhiren AU - Patel D AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cardinal Glennon Children's Hospital, Saint Louis University School of Medicine, St Louis, Missouri, USA. FAU - Khlevner, Julie AU - Khlevner J AUID- ORCID: 0000-0001-8166-0382 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Columbia University Vagelos College of Physicians and Surgeons, New York-Presbyterian Morgan Stanley Children's Hospital, New York, New York, USA. FAU - Saps, Miguel AU - Saps M AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Miami, Miller School of Medicine, Miami, Florida, USA. LA - eng PT - Journal Article PL - England TA - Neurogastroenterol Motil JT - Neurogastroenterology and motility JID - 9432572 SB - IM MH - Humans MH - Adolescent MH - *Transition to Adult Care/standards MH - Young Adult MH - North America MH - Female MH - *Gastroenterology MH - Adult MH - *Gastrointestinal Diseases/therapy MH - Male MH - Surveys and Questionnaires PMC - PMC13350998 OTO - NOTNLM OT - DGBI OT - adolescents and young adults OT - neurogastroenterology and motility OT - transition of care COIS- The authors declare no conflicts of interest. EDAT- 2026/07/10 06:35 MHDA- 2026/07/10 13:18 PMCR- 2026/07/10 CRDT- 2026/07/10 00:33 PHST- 2026/05/27 00:00 [revised] PHST- 2026/03/04 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/10 13:18 [medline] PHST- 2026/07/10 06:35 [pubmed] PHST- 2026/07/10 00:33 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - NMO70394 [pii] AID - 10.1111/nmo.70394 [doi] PST - ppublish SO - Neurogastroenterol Motil. 2026 Jul;38(7):e70394. doi: 10.1111/nmo.70394. PMID- 42426888 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261004 LR - 20261007 IS - 2731-4391 (Electronic) IS - 2731-4391 (Linking) VI - 5 IP - 1 DP - 2026 Jul 9 TI - Not all screen time is sedentary: evidence from aligned smartphone sensing and accelerometry data in adults. LID - 10.1186/s44167-026-00109-y [doi] LID - 18 AB - BACKGROUND: Screen time is frequently used as a proxy for sedentary behaviour in physical activity and public health research, an assumption largely derived from television viewing. However, because smartphones are portable, screentime can occur across diverse physical contexts. This raises uncertainty about whether it reliably reflects sedentary behaviour at the momentary level. METHODS: This opportunistic analysis used data from an ongoing cohort study of adult caregivers of preschool-aged children. Smartphone screen time was objectively assessed using the Android-based passive sensing app Chronicle, and movement behaviour was assessed using wrist-worn accelerometers. Accelerometer data were processed using GGIR and the SedUp algorithm to classify epochs as sedentary or non-sedentary. Smartphone and movement data were aligned at 5-s epochs during waking wear time. Primary outcomes included the proportion of smartphone screen-use time occurring during sedentary versus non-sedentary behaviour. Secondary analyses examined inactive versus active behaviour during non-sedentary screen use, and app-level differences. RESULTS: The analytic sample included 63 participants contributing 785 person-days (3.3-million 5-s epochs). At the participant level, the median proportion of smartphone use occurring during non-sedentary behaviour was 25.9%, with substantial inter-individual variability (range: 5.6-73.7%). Among non-sedentary screen-use epochs, 52.1% occurred during inactive behaviour and 47.9% occurred during active behaviour. App-level analyses revealed that social media applications were predominantly sedentary, whereas apps such as Phone, Maps, Camera, and YouTube showed higher proportions of non-sedentary use. CONCLUSIONS: Smartphone screen time fails as a momentary proxy for sedentary behaviour because a substantial, variable, and app-dependent proportion occurs during non-sedentary behaviour. These findings may have implications for both the measurement and development of interventions aimed at reducing sedentary behaviour and/or smartphone use. CI - (c) 2026. The Author(s). FAU - Culverhouse, Joshua AU - Culverhouse J AUID- ORCID: 0000-0001-5345-5760 AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. Josh.Culverhouse@sc.edu. FAU - Finnegan, Olivia L AU - Finnegan OL AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Bowen, Kaia AU - Bowen K AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Nelakuditi, Srihari AU - Nelakuditi S AD - Department of Computer Science and Engineering, University of South Carolina, Columbia, SC, USA. FAU - Ghosal, Rahul AU - Ghosal R AD - Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA. FAU - Radesky, Jenny S AU - Radesky JS AD - University of Michigan Medical School, Ann Arbor, MI, USA. FAU - Adair, Taylor AU - Adair T AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Restino, Meghan AU - Restino M AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - White, James W 3rd AU - White JW 3rd AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Zhong, Zifei AU - Zhong Z AD - Department of Computer Science and Engineering, University of South Carolina, Columbia, SC, USA. FAU - Hadj-Amar, Beniamino AU - Hadj-Amar B AD - Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA. FAU - Holmes, Anthony AU - Holmes A AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Kiely, Keagan AU - Kiely K AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Burkart, Sarah AU - Burkart S AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Adams, Elizabeth L AU - Adams EL AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Weaver, R Glenn AU - Weaver RG AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Beets, Michael AU - Beets M AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. FAU - Armstrong, Bridget AU - Armstrong B AD - Department of Exercise Science, University of South Carolina, Columbia, SC, 29208, USA. LA - eng GR - R01 HD112311/HD/NICHD NIH HHS/United States GR - T32 GM081740/GM/NIGMS NIH HHS/United States GR - T32GM081740-15/NH/NIH HHS/United States GR - R01HD112311/NH/NIH HHS/United States PT - Journal Article DEP - 20260709 PL - England TA - J Act Sedentary Sleep Behav JT - Journal of activity, sedentary and sleep behaviors JID - 9918664288206676 PMC - PMC13637156 OTO - NOTNLM OT - Proxy OT - Screen time OT - Sedentary behaviour OT - Smartphone use COIS- Declarations. Ethics approval and consent to participate: Both included studies were approved by the University of South Carolina Institutional Review Board (pilot: Pro00092634, August 2020; cohort: Pro00133829, December 2023). Participants provided informed consent prior to participating. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/07/10 06:34 MHDA- 2026/07/10 06:35 PMCR- 2026/07/09 CRDT- 2026/07/10 00:20 PHST- 2026/03/24 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/10 06:35 [medline] PHST- 2026/07/10 06:34 [pubmed] PHST- 2026/07/10 00:20 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - 10.1186/s44167-026-00109-y [pii] AID - 109 [pii] AID - 10.1186/s44167-026-00109-y [doi] PST - epublish SO - J Act Sedentary Sleep Behav. 2026 Jul 9;5(1):18. doi: 10.1186/s44167-026-00109-y. PMID- 42426319 OWN - NLM STAT- Publisher LR - 20260709 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 9 TI - Explainable machine learning integrating environmental chemical biomarkers and maternal clinical factors for prediction of hypertensive disorder of pregnancy. LID - 10.1038/s41598-026-61841-8 [doi] AB - Hypertensive disorders of pregnancy (HDP) represent a leading cause of maternal morbidity, yet environmental chemical contributors to HDP risk remain poorly characterized within predictive frameworks. We developed and evaluated an explainable machine-learning model integrating environmental biomarkers with maternal clinical characteristics for HDP prediction using data from 4,260 pregnant women enrolled in the Korean Children's Environmental Health Study (Ko-CHENS) prospective birth cohort. An Extreme Gradient Boosting (XGBoost) classifier incorporating 18 environmental biomarkers-including blood lead, cadmium, mercury, and endocrine-disrupting chemicals-alongside maternal clinical covariates was trained using stratified 60/20/20 data splits with Bayesian hyperparameter optimization. The optimized model achieved a cross-validated ROC-AUC of 0.787 and an independent test ROC-AUC of 0.748 (95% CI: 0.587-0.887), with a negative predictive value of 0.994 under severe class imbalance (HDP prevalence: 1.7%). SHapley Additive exPlanations (SHAP) analysis identified late-pregnancy blood lead concentration and pre-pregnancy body mass index as the dominant predictors, each exhibiting non-linear risk gradients; formal SHAP interaction values (1.6% of combined attribution) and an independent logistic-regression interaction term (beta = 0.418, 95% CI - 0.278-1.115, p = 0.239) indicated additive rather than synergistic BMI-lead pathways. These findings demonstrate that environmental biomarkers contribute independent, non-linear predictive value beyond established clinical risk factors, supporting integration of environmental exposure surveillance into precision obstetric risk stratification. CI - (c) 2026. The Author(s). FAU - Wang, Changwon AU - Wang C AD - Department of Integrated Healthcare Science, Soonchunhyang University, Asan, 31538, Republic of Korea. FAU - Lee, Jong-Dae AU - Lee JD AD - Department of Environmental Health Science, Soonchunhyang University, Asan, 31538, Republic of Korea. FAU - Kim, Ju Hee AU - Kim JH AD - Department of Nursing, College of Nursing Science, Kyung Hee University, Seoul, 02447, Republic of Korea. juheekim@khu.ac.kr. LA - eng GR - No. 5199990914048/BK21 FOUR (Fostering Outstanding Universities for Research/ PT - Journal Article DEP - 20260709 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Environmental chemical exposure OT - Explainable artificial intelligence OT - Hypertensive disorder of pregnancy OT - Machine learning COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/10 00:36 MHDA- 2026/07/10 00:36 CRDT- 2026/07/09 23:35 PHST- 2026/04/04 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/10 00:36 [medline] PHST- 2026/07/10 00:36 [pubmed] PHST- 2026/07/09 23:35 [entrez] AID - 10.1038/s41598-026-61841-8 [pii] AID - 10.1038/s41598-026-61841-8 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 9. doi: 10.1038/s41598-026-61841-8. PMID- 42426095 OWN - NLM STAT- Publisher LR - 20260709 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 9 TI - Integrated framework for pediatric height assessment: X-ray-based height extreme cases classification and machine learning for multivariate height prediction. LID - 10.1038/s41598-026-56423-7 [doi] AB - Pediatric height assessment is crucial for evaluating growth and enabling timely intervention. However, traditional methods primarily assess current bone age rather than identifying future height abnormalities. This study proposes an integrated framework with two components: one uses hand X-ray images and clinical features to predict potential extreme height cases after one year; the other employs multivariate data to predict height across different time scales. To predict potential extreme cases, we employed fine-tuned Inception-ResNet-V2 as our classification model, while addressing class data imbalance through the DSEV method. For multivariate height prediction, we used XGBoost as our prediction model, incorporating various anthropometric and medical features, such as sex, age, body height, birth weight, medical diagnosis, and treatment. Results demonstrate that our classification models achieved outstanding performance in detecting unexpectedly short and unexpectedly tall cases, showing exceptional accuracy and reliability. Our multivariate prediction models demonstrated very low mean absolute error for predictions within 6 months, 1 year, 2 years, and near-final adult height, with consistent and stable performance. This integrated framework provides clinicians with more precise and comprehensive tools for evaluating children's growth and planning interventions. CI - (c) 2026. The Author(s). FAU - Chang, Ya-Wen AU - Chang YW AD - Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, 701, Taiwan ROC. FAU - Tsai, Meng-Che AU - Tsai MC AD - Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan ROC. mengchets@gs.ncku.edu.tw. FAU - Hsieh, Sun-Yuan AU - Hsieh SY AD - Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, 701, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - The Institute of Information Science, Academia Sinica, Taipei, 115201, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - The Research Center for Information Technology Innovation, Academia Sinica, Taipei, 115201, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - The Institute of Medical Informatics, National Cheng Kung University, Tainan, 701, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - Institute of Manufacturing Information and Systems, National Cheng Kung University, Tainan, 701, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. LA - eng PT - Journal Article DEP - 20260709 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Artificial Intelligence OT - Bone Age OT - Deep Learning OT - Growth Abnormalities OT - Hand X-ray OT - Height Prediction OT - Machine Learning COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/10 00:35 MHDA- 2026/07/10 00:35 CRDT- 2026/07/09 23:26 PHST- 2025/11/22 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/07/10 00:35 [medline] PHST- 2026/07/10 00:35 [pubmed] PHST- 2026/07/09 23:26 [entrez] AID - 10.1038/s41598-026-56423-7 [pii] AID - 10.1038/s41598-026-56423-7 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 9. doi: 10.1038/s41598-026-56423-7. PMID- 42425539 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) VI - 158 IP - 2 DP - 2026 Aug 1 TI - Portrayals of Food and Nutrition in Popular US Picture Books. LID - e2025074460 [pii] LID - 10.1542/peds.2025-074460 [doi] AB - BACKGROUND: Early experiences shape how children understand food as part of their health, family, and culture. Pediatricians promote picture book reading to support developmental and relational health. We conducted a pediatric-informed content analysis of food and nutrition in US picture books. METHODS: Using an interdisciplinary content analysis framework, we assessed food and nutrition content within a representative sample of US picture books (N = 159). Coders documented the presence and types of food, mealtimes, and social drivers of nutritional health. We assessed interrater reliability and summarized food-related content within the context of how the book depicted the role and function of food. RESULTS: The kappa agreement ranged from 78% to 99% (strong reliability). Most books depicted food in text (67%) or pictures (68%). Fruit (39%) was the most depicted food group, milk the most depicted beverage (15%), and sweet the most depicted flavor (33%). Among books that included meals, snacks were most common (57%), followed by dinner (41%). Characters ate with their families in over half (53%) of books that depicted meals. Food often symbolized a role beyond satiating hunger (eg, rewarding behavior, fostering connection). Specific roles were associated with a higher appearance of certain foods (eg, fruits with pleasure). CONCLUSIONS: Picture books, which frequently portray food and reliably capture children's interest, are helpful tools to engage children in conversations about the social, cultural, and nutritional functions of food. Our findings suggest that picture books are a commercial-free early literacy tool that can support integrated interventions addressing both nutritional and relational health. CI - Copyright (c) 2026 by the American Academy of Pediatrics. FAU - Duh-Leong, Carol AU - Duh-Leong C AD - Department of Pediatrics, NYU Grossman School of Medicine, New York, New York. FAU - Klass, Perri AU - Klass P AD - Department of Pediatrics, NYU Grossman School of Medicine, New York, New York. AD - Arthur L. Carter Journalism Institute, New York University, New York, New York. FAU - Nagpal, Nikita AU - Nagpal N AD - Department of Pediatrics, NYU Grossman School of Medicine, New York, New York. FAU - Palacio Mazo, Laura AU - Palacio Mazo L AD - Department of Pediatrics, NYU Grossman School of Medicine, New York, New York. FAU - Warda, Elise AU - Warda E AD - Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Tyson, Kendra AU - Tyson K AD - Constantine Georgiou Library and Resource Center for Children and Literature, NYU Steinhardt School of Culture, Education, and Human Development, New York, New York. FAU - Aristy, Claudia AU - Aristy C AD - Reach Out and Read, NYC Health + Hospitals Bellevue, New York, New York. FAU - Takahashi Oakland, Hannah AU - Takahashi Oakland H AD - Department of Medicine, Emory University School of Medicine, Atlanta, Georgia. FAU - Perrin, Eliana M AU - Perrin EM AD - Department of Pediatrics, Johns Hopkins University Schools of Medicine and Nursing, Baltimore, Maryland. LA - eng PT - Journal Article PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 SB - IM MH - Humans MH - United States MH - *Books MH - *Food MH - Child EDAT- 2026/07/10 00:35 MHDA- 2026/08/01 00:36 CRDT- 2026/07/09 20:04 PHST- 2025/09/24 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/08/01 00:36 [medline] PHST- 2026/07/10 00:35 [pubmed] PHST- 2026/07/09 20:04 [entrez] AID - 208199 [pii] AID - 10.1542/peds.2025-074460 [doi] PST - ppublish SO - Pediatrics. 2026 Aug 1;158(2):e2025074460. doi: 10.1542/peds.2025-074460. PMID- 42425140 OWN - NLM STAT- Publisher LR - 20260813 IS - 1469-445X (Electronic) IS - 0958-0670 (Print) IS - 0958-0670 (Linking) DP - 2026 Jul 9 TI - Physiological evaluation of the Calgary adapted aRm ergometer (CARE) concussion exertion test in adolescent athletes: A repeated-measures observational study. LID - 10.1113/EP093264 [doi] AB - Exertion testing helps inform exercise prescription during concussion recovery. The Calgary Adapted aRm Ergometer (CARE) test, developed as the first upper-body specific exertion test, aims to improve accessibility and inclusivity in concussion care. While initial development was conducted in adults, its applicability in adolescents remains unknown. This study compared physiological responses between the CARE test and the Calgary Concussion Cycle Test (CCCT) in non-disabled adolescent male and female athletes. Fifteen females and fifteen males (aged 14-17) performed CARE and CCCT to volitional fatigue. Response differences, Bland-Altman plots, effect sizes, intraclass correlation and moderation by sex for heart rate (HR), middle cerebral artery velocity (MCAv), volume of oxygen consumption ( V̇O2 ), minute ventilation ( V̇E ) and end-tidal carbon dioxide ( PETCO2 ) were analysed at 25%, 50%, 75% and 100% of peak exertion levels. CARE elicited lower absolute values for HR, MCAv, PETCO2 , V̇O2 and V̇E compared to CCCT, with differences and 95% limits-of-agreement becoming more pronounced at higher intensities. For mild-to-moderate exercise (25-50% exertion), the range typically used in clinical concussion testing, HR and MCAv differences were small for both sexes. Near maximal intensity, the HR gap widened, but MCAv was comparable. Sex did not modify the relationship between tests for HR and MCAv. While CARE predominantly employs smaller muscle mass than CCCT, results showed robust and relatively comparable physiological responses between tests and between male and female adolescents. These findings further support CARE as an accessible and inclusive post-concussion exertion test for those not able to perform lower-body protocols. CI - (c) 2026 The Author(s). Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. FAU - Burkart, Joshua J AU - Burkart JJ AUID- ORCID: 0009-0000-2142-7669 AD - Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. AD - Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada. FAU - Neill, Matthew G AU - Neill MG AUID- ORCID: 0009-0000-5397-208X AD - Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. AD - Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada. FAU - Galarneau, Jean-Michel AU - Galarneau JM AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. FAU - Wilder, Tegan AU - Wilder T AD - Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. FAU - Johns, Sarah AU - Johns S AUID- ORCID: 0009-0007-8480-1014 AD - Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Carere, Joseph AU - Carere J AD - Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Leddy, John J AU - Leddy JJ AD - UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, New York, USA. FAU - Haider, Mohammad N AU - Haider MN AD - UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, New York, USA. FAU - Adams, William M AU - Adams WM AD - Adams Sports Medicine Consulting LLC, Colorado Springs, Colorado, USA. AD - Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, North Carolina, USA. AD - School of Sport, Exercise and Health Sciences, National Centre for Sport and Exercise Medicine, Loughborough University, Loughborough, UK. AD - Department of Kinesiology, Michigan State University, East Lansing, Michigan, USA. FAU - Blauwet, Cheri AU - Blauwet C AD - Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation/Harvard Medical School, Boston, Massachusetts, USA. FAU - Debert, Chantel T AU - Debert CT AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Emery, Carolyn A AU - Emery CA AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Smirl, Jonathan D AU - Smirl JD AD - Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. AD - Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada. LA - eng GR - RGPIN-2020-04057/Natural Sciences and Engineering Research Council of Canada/ GR - CGSD3-559333-2021/Natural Sciences and Engineering Research Council of Canada/ GR - CAPMC/CIHR/Canada GR - University of Calgary, Faculty of Kinesiology/ GR - Foundation Brain Canada/ GR - Brain Changes Initiative/ GR - Branch Out Neurological Foundation/ GR - National Football League Play Smart Play Safe Program/ GR - Hotchkiss Brain Institute, University of Calgary/ PT - Journal Article DEP - 20260709 PL - England TA - Exp Physiol JT - Experimental physiology JID - 9002940 SB - IM PMC - PMC13394809 OTO - NOTNLM OT - adolescence OT - arm crank ergometry OT - exercise is medicine OT - exertion testing OT - sport-related concussion OT - transcranial doppler ultrasound COIS- None declared. EDAT- 2026/07/10 00:36 MHDA- 2026/07/10 00:36 PMCR- 2026/07/09 CRDT- 2026/07/09 18:53 PHST- 2025/08/31 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/10 00:36 [medline] PHST- 2026/07/10 00:36 [pubmed] PHST- 2026/07/09 18:53 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - EPH70384 [pii] AID - 10.1113/EP093264 [doi] PST - aheadofprint SO - Exp Physiol. 2026 Jul 9:10.1113/EP093264. doi: 10.1113/EP093264. PMID- 42425048 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1879-0046 (Electronic) IS - 0376-8716 (Linking) VI - 286 DP - 2026 Sep 1 TI - Youth's perception of parental limitation of youth screen time is associated with lower odds of nicotine vaping among US youth: Results from the 2024 National Survey on Drug Use and Health (NSDUH). PG - 113260 LID - S0376-8716(26)00241-3 [pii] LID - 10.1016/j.drugalcdep.2026.113260 [doi] AB - BACKGROUND: Youth media exposure is associated with vaping, while parental limitation of youth screen time may be associated with lower odds of youth vaping. Using nationally representative survey data, this study examines these relationships. METHODS: We used youth (aged 12-17) data from the 2024 National Survey on Drug Use and Health (N = 11,334) and defined past-month nicotine vaping as a binary variable (yes/no). Past-year youth's perception of parental limitation of youth screen time (television, tablets, smartphones, computers, and video games) was categorized as never, seldom, sometimes, or always. To estimate associations between youth's perception of parental limitation of screen time and past-month nicotine vaping, we conducted binomial logistic regression, controlling for relevant covariates. RESULTS: Overall, 5.5% of adolescents reported past-month nicotine vaping; 29.9% reported that parents never limited screen time, compared with 16.6% who reported always limiting screen time. In adjusted models, higher levels of youth's perception of screen time limitation were associated with lower odds of past-month nicotine vaping (AOR = 0.78, 95% CI = 0.66, 0.92). Several sensitivity analyses validated the findings. CONCLUSIONS: These findings identify that youth's perception of parental limitation of screen time was associated with lower odds of nicotine vaping among youth. Future studies should assess direct parental reports of restriction of youth screen time and examine comprehensive media-use approaches that combine screen-time limits in addition to general parenting practices. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Lee, Juhan AU - Lee J AD - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, United States; Department of Epidemiology and Population Health, Montefiore Einstein Comprehensive Cancer Center, United States. Electronic address: juhan.lee@einsteinmed.edu. FAU - Mattingly, Delvon T AU - Mattingly DT AD - Department of Behavioral Science, University of Kentucky College of Medicine, United States; Center for Health, Engagement, and Transformation, University of Kentucky College of Medicine, United States. LA - eng PT - Journal Article DEP - 20260704 PL - Ireland TA - Drug Alcohol Depend JT - Drug and alcohol dependence JID - 7513587 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Child MH - *Vaping/epidemiology/psychology MH - United States/epidemiology MH - *Screen Time MH - *Parents MH - Health Surveys MH - Media Exposure MH - *Perception OTO - NOTNLM OT - Media exposure OT - Nicotine vaping OT - Screen time OT - Youth COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/10 04:10 MHDA- 2026/09/04 23:36 CRDT- 2026/07/09 18:11 PHST- 2026/03/15 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/07/10 04:10 [pubmed] PHST- 2026/07/09 18:11 [entrez] AID - S0376-8716(26)00241-3 [pii] AID - 10.1016/j.drugalcdep.2026.113260 [doi] PST - ppublish SO - Drug Alcohol Depend. 2026 Sep 1;286:113260. doi: 10.1016/j.drugalcdep.2026.113260. Epub 2026 Jul 4. PMID- 42424543 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1751-7893 (Electronic) IS - 1751-7885 (Print) IS - 1751-7885 (Linking) VI - 20 IP - 7 DP - 2026 Jul TI - A Randomised Feasibility Trial of a Service-Coordinated Exercise Intervention in First-Episode Psychosis: Challenges in Implementation and Outcome Assessment. PG - e70193 LID - 10.1111/eip.70193 [doi] LID - e70193 AB - BACKGROUND: Psychosis is increasingly recognised as a systemic disorder characterised by interrelated metabolic dysfunction, chronic low-grade inflammation and sedentary lifestyles. Physical exercise is a promising intervention to address this triad. This pilot study investigated the feasibility and systemic impact of a pragmatic exercise intervention within a first-episode psychosis (FEP) service. METHODS: We conducted a parallel-group randomised controlled trial involving people with FEP, comparing an 8-week structured aerobic and resistance training programme to Treatment As Usual. We assessed feasibility of the intervention and assessments by measuring recruitment, attendance, retention, and engagement with assessments. Exploratory outcome measures spanned physical fitness, metabolic health, psychometric scales and the Cambridge Neuropsychological Test Automated Battery (CANTAB) cognitive battery. RESULTS: The study recruited 40 participants, 19 in the intervention and 21 in the control group. At baseline assessment, 23 of 38 had an elevated BMI and 24 of 35 had elevated cholesterol. Study retention was adequate, with only four participants (10%) lost to follow up. However, the assessment battery was poorly completed, highlighting its infeasibility. Fitness outcomes proved especially challenging, with between 11 and 13 participants (27.5% to 32.5%) completing both baseline and endpoint assessments. Of the 19 people recruited to the intervention arm, 7 (36.8%) attended less than half of the 8 sessions. Outcome data were limited by substantial missingness, with no consistent pattern of benefit or harm observed across domains. CONCLUSIONS: Implementing exercise within real-world FEP services is challenging as indicated by the attrition observed in our study. Future research should individualise exercise prescription and minimise participant assessment burden to mitigate attrition. CI - (c) 2026 The Author(s). Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd. FAU - O'Mahony, Brian W AU - O'Mahony BW AUID- ORCID: 0000-0002-1530-0167 AD - UCD Centre for Psychosis Research, School of Medicine, University College Dublin, Dublin, Ireland. FAU - Wycherley, Elizabeth AU - Wycherley E AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Daly, Karen AU - Daly K AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Cowman, Meghan AU - Cowman M AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Lonergan, Edgar AU - Lonergan E AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Owens, Abigale AU - Owens A AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - O'Mahony, Karen AU - O'Mahony K AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - O'Donoghue, Brian AU - O'Donoghue B AUID- ORCID: 0000-0001-6240-6952 AD - UCD Centre for Psychosis Research, School of Medicine, University College Dublin, Dublin, Ireland. AD - Department of Psychiatry, St Vincent's University Hospital, Dublin, Ireland. FAU - Clarke, Gerard AU - Clarke G AUID- ORCID: 0000-0001-9771-3979 AD - Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland. AD - APC Microbiome Ireland, Biosciences Research Institute, University College Cork, Cork, Ireland. FAU - O'Connor, Karen AU - O'Connor K AUID- ORCID: 0000-0003-0696-8576 AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. AD - Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland. LA - eng GR - ICAT-2022-001/HRBI_/Health Research Board/Ireland PT - Journal Article PT - Pragmatic Clinical Trial PT - Randomized Controlled Trial PL - Australia TA - Early Interv Psychiatry JT - Early intervention in psychiatry JID - 101320027 SB - IM MH - Humans MH - *Psychotic Disorders/therapy/psychology MH - Female MH - Feasibility Studies MH - Male MH - Adult MH - Pilot Projects MH - *Exercise Therapy/methods MH - Young Adult MH - *Outcome Assessment, Health Care MH - *Exercise MH - Adolescent PMC - PMC13349341 OTO - NOTNLM OT - attrition OT - exercise OT - feasibility OT - first-episode psychosis OT - metabolic health OT - physical health COIS- G.C. received honoraria from Janssen, Heel Pharmaceuticals, Probi, Boehringer Ingelheim and Apsen as an invited speaker; and research funding from Pharmavite, Reckitt, Tate and Lyle, Nestle and Fonterra. G.C. is or has been a paid consultant for Heel Pharmaceuticals, Bayer Healthcare, Yakult and Zentiva. All other authors declare no competing interests. EDAT- 2026/07/09 22:36 MHDA- 2026/07/10 12:45 PMCR- 2026/07/09 CRDT- 2026/07/09 15:23 PHST- 2026/06/05 00:00 [revised] PHST- 2026/05/01 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/10 12:45 [medline] PHST- 2026/07/09 22:36 [pubmed] PHST- 2026/07/09 15:23 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - EIP70193 [pii] AID - 10.1111/eip.70193 [doi] PST - ppublish SO - Early Interv Psychiatry. 2026 Jul;20(7):e70193. doi: 10.1111/eip.70193. PMID- 42423735 OWN - NLM STAT- Publisher LR - 20260709 IS - 1432-0932 (Electronic) IS - 0940-6719 (Linking) DP - 2026 Jul 9 TI - Determining the minimal clinically important difference of angle of trunk rotation for monitoring conservatively treated adolescent idiopathic scoliosis. LID - 10.1007/s00586-026-10179-w [doi] AB - PURPOSE: The angle of trunk rotation (ATR) is widely used in the clinical follow-up of adolescent idiopathic scoliosis (AIS); however, the minimal clinically important difference (MCID) has not been clearly defined. This study aimed to determine treatment-specific MCID values for ATR in conservatively treated AIS patients. METHODS: This retrospective cohort study included 316 AIS patients treated with brace plus exercise or exercise alone. Radiographic outcomes at 6 months were classified as improvement (DeltaCobb /= + 5 degrees ). Receiver operating characteristic (ROC) analyses were performed to determine optimal DeltaATR cut-off values for clinically meaningful improvement and worsening in the overall cohort and separately by treatment group. RESULTS: In the overall cohort, DeltaATR showed good discriminative ability for improvement (AUC = 0.778) and worsening (AUC = 0.777). The optimal cut-offs were DeltaATR /= + 0.5 degrees for worsening. In subgroup analyses, the improvement threshold was DeltaATR /= + 0.5 degrees in the exercise-only group and >/= - 2.5 degrees in the brace-plus-exercise group. CONCLUSIONS: Treatment-specific DeltaATR thresholds provide clinically meaningful benchmarks for monitoring both improvement and worsening, supporting the use of ATR as a practical radiation-free follow-up parameter in AIS management. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Kuru Colak, Tugba AU - Kuru Colak T AUID- ORCID: 0000-0002-3263-2278 AD - Faculty of Health Science, Department of Physiotherapy and Rehabilitation, Marmara University, Istanbul, Turkey. cktugba@gmail.com. FAU - Akcay Genal, Burcin AU - Akcay Genal B AD - Faculty of Physical Therapy and Rehabilitation, Department of Prosthetics and Orthotics, Dokuz Eylul University, Izmir, Turkey. FAU - Colak, Ilker AU - Colak I AD - Faculty of Medicine, Department of Orthopaedics and Traumatology, Istinye University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260709 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Angle of trunk rotation OT - Exercise therapy OT - Minimal clinically important difference OT - Orthotic devices OT - Scoliometer OT - Treatment outcome COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/09 12:33 MHDA- 2026/07/09 12:33 CRDT- 2026/07/09 11:05 PHST- 2026/02/25 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/05/28 00:00 [revised] PHST- 2026/07/09 12:33 [medline] PHST- 2026/07/09 12:33 [pubmed] PHST- 2026/07/09 11:05 [entrez] AID - 10.1007/s00586-026-10179-w [pii] AID - 10.1007/s00586-026-10179-w [doi] PST - aheadofprint SO - Eur Spine J. 2026 Jul 9. doi: 10.1007/s00586-026-10179-w. PMID- 42423536 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20260929 IS - 2198-3844 (Electronic) IS - 2198-3844 (Linking) VI - 13 IP - 54 DP - 2026 Sep TI - Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population-Based Study and Gut Microbiota Analysis. PG - e76460 LID - 10.1002/advs.76460 [doi] LID - e76460 AB - Although substantial evidence links sweetened beverage (SB) intake to chronic diseases, its association with biological aging and underlying mechanisms remains unclear. This population-based study included 9104 adults aged 18-80 years from the WELL-China cohort. SB consumption was assessed using a validated food frequency questionnaire. Biological age and biological age acceleration (BAacc) were estimated using the Klemera and Doubal method (KDM). After multivariable adjustment, frequent SB consumption was significantly associated with accelerated KDM-derived BAacc, compared with non-consumers (beta = 0.29 years, 95% CI: 0.06-0.52). This association was stronger among participants younger than 55 years (P for interaction < 0.05). Gut microbiota was profiled using 16S rRNA gene sequencing. We identified 10 genera significantly associated with the frequent SB consumption, and 56 genera significantly associated with BAacc. Notably, five genera (Allisonella, Lactobacillus, Weissella, Lactococcus, and Bacilli_unclassified) were shared between the two analyses and enriched in both frequent SB consumers and individuals with higher BAacc. Frequent SB consumption is associated with accelerated biological aging, especially among adults younger than 55 years. Shared gut microbial signatures associated with both SB intake and BAacc suggest a potential microbiota-related pathway. These findings support reducing SB consumption as a potential strategy for promoting healthy aging. CI - (c) 2026 The Author(s). Advanced Science published by Wiley-VCH GmbH. FAU - Shi, Yuwei AU - Shi Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Li, Xinmei AU - Li X AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Hao, Yufan AU - Hao Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Wu, Qiaoyu AU - Wu Q AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Yu, Yuji AU - Yu Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Li, Siyu AU - Li S AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Xu, Nuo AU - Xu N AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Wu, Yi-Hsuan AU - Wu YH AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Lee, Eunhye AU - Lee E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Chang, Chi AU - Chang C AD - Office of Medical Education Research and Development, College of Medicine, Michigan State University, East Lansing, Michigan, USA. FAU - Hu, Emily AU - Hu E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Lu, Ying AU - Lu Y AUID- ORCID: 0000-0002-7698-8962 AD - Department of Biomedical Data Science, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Delzell, Elizabeth AU - Delzell E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Hsing, Ann W AU - Hsing AW AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. AD - Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Stanford, California, USA. AD - Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Zhu, Shankuan AU - Zhu S AUID- ORCID: 0000-0002-9509-7364 AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. LA - eng GR - China Medical Board (CMB)/ GR - 419600-11102/Cyrus Tang Foundation/ GR - 419600-11107/Chou Fund of Zhejiang University Education Foundation/ PT - Journal Article DEP - 20260709 PL - Germany TA - Adv Sci (Weinh) JT - Advanced science (Weinheim, Baden-Wurttemberg, Germany) JID - 101664569 RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Gastrointestinal Microbiome/genetics/physiology MH - *Aging/physiology MH - Middle Aged MH - Adult MH - Aged MH - Female MH - Male MH - RNA, Ribosomal, 16S/genetics MH - China MH - Aged, 80 and over MH - Young Adult MH - *Sugar-Sweetened Beverages/adverse effects MH - Adolescent MH - Cohort Studies MH - *Beverages/adverse effects PMC - PMC13348652 OTO - NOTNLM OT - aging OT - biological age acceleration OT - gut microbiota OT - sweetened beverage COIS- The authors declare no conflicts of interest. EDAT- 2026/07/09 12:33 MHDA- 2026/09/28 11:38 PMCR- 2026/07/09 CRDT- 2026/07/09 10:23 PHST- 2026/06/13 00:00 [revised] PHST- 2026/01/20 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/09/28 11:38 [medline] PHST- 2026/07/09 12:33 [pubmed] PHST- 2026/07/09 10:23 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - ADVS76460 [pii] AID - 10.1002/advs.76460 [doi] PST - ppublish SO - Adv Sci (Weinh). 2026 Sep;13(54):e76460. doi: 10.1002/advs.76460. Epub 2026 Jul 9. PMID- 42423249 OWN - NLM STAT- Publisher LR - 20260715 IS - 1469-7610 (Electronic) IS - 0021-9630 (Linking) DP - 2026 Jul 9 TI - The association between 24-hr movement patterns and self-harm incidence in adolescence. LID - 10.1111/jcpp.70199 [doi] AB - BACKGROUND: Self-harm is a pressing public health issue, particularly among adolescents. Physical activity is associated with reduced self-harm among youths, but evidence is limited. Most studies rely on self-reported measures and are primarily focused on moderate-to-vigorous physical activity (MVPA), often overlooking the role of light-intensity physical activity (LIPA). To address these gaps, we investigated the prospective associations between accelerometer-measured 24-hr movements and subsequent self-harm in adolescents. METHODS: This prospective cohort investigation analysed 2,016 children from the UK Millennium Cohort Study using data from the age 7 years survey (MCS4) when accelerometers were introduced (mean age = 7.23 years, SD = 0.25). Accelerometer-measured duration of MVPA, LIPA, sedentary behaviour (SB), and sleep were analysed. Self-harm behaviours were assessed via validated self-report questionnaires at ages 14 and 17 years, and subsequently, the associations examined using logistic and compositional data models. RESULTS: Among 2,016 participants (48.6% female), 548 self-harm cases occurred during 18,696 person-years of follow-up, with a median follow-up duration of 8.5 years (cumulative incidence = 27.2%). LIPA was inversely associated with self-harm (OR 0.76, 95% CI: 0.65-0.88). This association was stronger in compositional models (OR 0.23, 95% CI: 0.11-0.47). MVPA showed a significant non-linear, inverted U-shaped association with self-harm (p for non-linearity = .02). The risk peaked at approximately 1.2 hr/day and decreased substantially at levels exceeding 1.7 hr/day, while SB and sleep were not significantly associated with self-harm. Stratified analyses confirmed robustness. CONCLUSIONS: Our findings reveal a pronounced inverse association between LIPA and self-harm, along with a non-linear association for MVPA. These results support 24-hr movement guidelines that emphasise activity transitions over isolated targets and highlight LIPA's role in early prevention strategies. CI - (c) 2026 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. FAU - Huang, Siyi AU - Huang S AUID- ORCID: 0000-0002-9461-2029 AD - Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China. AD - Department of Sports Science, College of Education, Zhejiang University, Hangzhou, China. FAU - Cui, Jiameng AU - Cui J AD - Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. FAU - He, Qida AU - He Q AD - Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China. FAU - Ali, Shahmir H AU - Ali SH AD - Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. FAU - Wang, Qi AU - Wang Q AD - Department of Data Science, City University of Hong Kong, Hong Kong, China. FAU - Thomas, G Neil AU - Thomas GN AD - Department of Applied Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK. FAU - Li, Linyan AU - Li L AD - Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China. AD - Department of Data Science, City University of Hong Kong, Hong Kong, China. LA - eng GR - CityU21607223/Research Grants Council, University Grants Committee, Hong Kong/ GR - 7020097;7030008/City University of Hong Kong/ GR - City University of Hong Kong Institute of Digital Medicine/ PT - Journal Article DEP - 20260709 PL - England TA - J Child Psychol Psychiatry JT - Journal of child psychology and psychiatry, and allied disciplines JID - 0375361 SB - IM OTO - NOTNLM OT - Millennium Cohort Study OT - Non-suicidal self-harm OT - compositional data analysis OT - light-intensity physical activity OT - youth mental health EDAT- 2026/07/09 13:24 MHDA- 2026/07/09 13:24 CRDT- 2026/07/09 07:52 PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/09 13:24 [pubmed] PHST- 2026/07/09 13:24 [medline] PHST- 2026/07/09 07:52 [entrez] AID - 10.1111/jcpp.70199 [doi] PST - aheadofprint SO - J Child Psychol Psychiatry. 2026 Jul 9. doi: 10.1111/jcpp.70199. PMID- 42422709 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Prevalence and factors associated with adolescent idiopathic scoliosis in Shanghai, China: an artificial intelligence-assisted screening approach. PG - 1832421 LID - 10.3389/fpubh.2026.1832421 [doi] LID - 1832421 AB - OBJECTIVE: To investigate the prevalence of adolescent idiopathic scoliosis (AIS) and major modifiable factors associated with AIS among school students in Shanghai, China, and assess the feasibility and validated accuracy of AI-assisted 3D screening in school health management. METHODS: A multistage stratified cluster sampling design was employed in this cross-sectional study, conducted from July 2024 to June 2025. A structured-light 3D back-scanning AI system was used to screen 5,026 students aged 9-15 years from six schools in five districts of Shanghai. Physical fitness tests and questionnaires were used to collect data on body morphology, posture, physical activity, and lifestyle. Standing full-spine radiography was used as the reference standard for AIS diagnosis, defined as Cobb angle >/=10 degrees . Because radiographic verification was performed for all screen-positive students but only for a random subset of screen-negative students, inverse probability weighting was applied to account for partial verification. RESULTS: Among the 5,026 screened students, 160 AIS cases were confirmed among 185 rescreen-positive students, and 2 additional AIS cases were identified among 300 randomly verified screen-negative students. The crude radiographically confirmed detection rate was 3.2% (162/5,026), and the IPW-adjusted estimated population prevalence was 3.8%. Thoracic curves and Cobb angles of 10 degrees - < 20 degrees were most common. Girls and middle school students had higher crude radiographic detection rates than boys and primary school students, respectively. Multivariable binary logistic regression identified female sex, improper sitting posture among girls, very low post-exercise fatigue among boys, and frequent one-sided exertion sports as factors associated with screening-detected AIS, whereas higher BMI, balanced walking posture, and satisfactory sleep quality showed protective associations. The AI-assisted structured-light screening workflow showed IPW-adjusted sensitivity of 0.832, specificity of 0.995, PPV of 0.865, NPV of 0.993, and overall accuracy of 0.989. CONCLUSION: AIS represents a non-negligible spinal health burden among school students in Shanghai. Most factors associated with AIS are modifiable. The AI-assisted structured-light screening workflow demonstrated acceptable diagnostic accuracy and promising feasibility for large-scale school-based health screening and management integration. CI - Copyright (c) 2026 Cao, Li, Zhang, Gu, Zheng, Li, Liu, Feng, Yang, Zhang, Xie, Yu, Wu and Xia. FAU - Cao, Yuanyuan AU - Cao Y AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Li, Fangfang AU - Li F AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zhang, Yong AU - Zhang Y AD - Education Bureau of Baoshan District, Shanghai, China. FAU - Gu, Wenwen AU - Gu W AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zheng, Xinfeng AU - Zheng X AD - Department of Spine Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Li, Meng AU - Li M AD - Dongciyuan Intelligent Technology Co., Ltd., Shanghai, China. FAU - Liu, Xu AU - Liu X AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Feng, Mengjia AU - Feng M AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Yang, Xilin AU - Yang X AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zhang, Yulu AU - Zhang Y AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Xie, Shu AU - Xie S AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Yu, Lijuan AU - Yu L AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Wu, Weibing AU - Wu W AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Xia, Jun AU - Xia J AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Scoliosis/epidemiology/diagnosis MH - Female MH - Male MH - China/epidemiology MH - Adolescent MH - Cross-Sectional Studies MH - Prevalence MH - Child MH - *Mass Screening/methods MH - *Artificial Intelligence MH - Risk Factors MH - Surveys and Questionnaires MH - Intelligent Systems PMC - PMC13344153 OTO - NOTNLM OT - 3D camera OT - AI-assisted screening OT - adolescent idiopathic scoliosis OT - machine learning OT - prevalence OT - risk factors COIS- ML was employed by Dongciyuan Intelligent Technology Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:32 MHDA- 2026/07/09 06:33 PMCR- 2026/06/24 CRDT- 2026/07/09 04:46 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 04:46 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1832421 [doi] PST - epublish SO - Front Public Health. 2026 Jun 24;14:1832421. doi: 10.3389/fpubh.2026.1832421. eCollection 2026. PMID- 42422693 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Association between physical activity and mental health among Yi students aged 10-18 years in Southwest China: a school-based cross-sectional study. PG - 1878144 LID - 10.3389/fpubh.2026.1878144 [doi] LID - 1878144 AB - BACKGROUND: Physical activity is a modifiable behavior that may contribute to youth mental health, yet evidence from ethnic minority school populations in Southwest China remains limited. METHODS: This school-based cross-sectional study analyzed questionnaire data from 671 Yi students aged 10-18 years. Physical activity was assessed using an 8-item PAQ-like measure. Mental health was operationalized through three adverse domains: anxiety, loneliness, and social anxiety. Age, sex, and school stage were included as covariates. Psychometric performance was examined using Cronbach's alpha, the Kaiser-Meyer-Olkin statistic, and Bartlett's test of sphericity. Primary associations were estimated with ordinary least squares regression using HC3 robust standard errors, followed by sex- and stage-stratified models, PAQ tertile analyses, linear trend tests, strict complete-item sensitivity analyses, and exploratory parenting extension models. RESULTS: The final sample included 379 girls and 292 boys with a mean age of 13.87 years. Reliability was acceptable to excellent across the four core scales (alpha = 0.709-0.938), and factorability indices supported the use of scores in this sample. Physical activity was inversely correlated with loneliness (r = -0.114, p = 0.003), but not with anxiety or social anxiety. After adjustment, higher physical activity remained associated with lower loneliness (B = -2.13, 95% CI -3.40 to -0.85, p = 0.001), whereas associations with anxiety and social anxiety were not significant. Follow-up analyses showed that the inverse PAQ-loneliness association was more evident among boys and among upper primary and junior secondary students, and the loneliness gradient across PAQ tertiles was statistically significant. In exploratory contextual models, the PAQ coefficient attenuated after father- and mother-related parenting composites were added, while father support and father harsh control showed clear associations with loneliness. CONCLUSION: In this minority school sample, the mental health pattern associated with physical activity was selective rather than global. Higher physical activity was most consistently linked to lower loneliness, while its associations with anxiety and social anxiety were not robust. These findings support a more contextualized public health interpretation of youth physical activity, in which relational connectedness and family climate may shape psychological benefits. CI - Copyright (c) 2026 Shao, Zhang, Li and Wang. FAU - Shao, Qingju AU - Shao Q AD - School of Physical Education, Sichuan Normal University, Chengdu, China. FAU - Zhang, Xiaolin AU - Zhang X AD - School of Physical Education, Sichuan Normal University, Chengdu, China. FAU - Li, Xuefang AU - Li X AD - School of Marxism, Chongqing Normal University, Chongqing, China. FAU - Wang, Jiaheng AU - Wang J AD - School of Physical Education, Sichuan Normal University, Chengdu, China. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - China/epidemiology MH - Child MH - *Mental Health/statistics & numerical data/ethnology MH - *Exercise/psychology MH - Loneliness/psychology MH - *Students/psychology/statistics & numerical data MH - Surveys and Questionnaires MH - Anxiety/epidemiology MH - Schools PMC - PMC13342181 OTO - NOTNLM OT - Yi students OT - loneliness OT - mental health OT - physical activity OT - school health OT - social anxiety COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:33 MHDA- 2026/07/09 06:34 PMCR- 2026/06/24 CRDT- 2026/07/09 04:46 PHST- 2026/05/11 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/09 06:34 [medline] PHST- 2026/07/09 06:33 [pubmed] PHST- 2026/07/09 04:46 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1878144 [doi] PST - epublish SO - Front Public Health. 2026 Jun 24;14:1878144. doi: 10.3389/fpubh.2026.1878144. eCollection 2026. PMID- 42422684 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Physical activity, dietary habits, screen time, and sleep duration among Saudi male adolescent athletes and non-athletes: a cross-sectional study. PG - 1871762 LID - 10.3389/fpubh.2026.1871762 [doi] LID - 1871762 AB - BACKGROUND: Adolescence represents a pivotal stage for the development of lifelong health behaviors. In Saudi Arabia, rising obesity and sedentary lifestyles among youth represent growing public health challenges. While organized sports may positively influence lifestyle behaviors, evidence comparing Saudi adolescent athletes and non-athletes across multiple behavioral domains remains limited. PURPOSE: To compare lifestyle habits, including physical activity levels, sedentary behaviors, dietary practices, and sleep duration, between Saudi male adolescent athletes and non-athletes. METHOD: A cross-sectional study of 124 male high school students aged 16-17 years (70 athletes, 54 non-athletes) from Riyadh used a validated 47-item Arab Teen Lifestyle Study (ATLS) questionnaire. Physical activity was measured in METs-minutes per week. Chi-square tests, independent t-tests, and multiple linear regression were applied. RESULT: Athletes exhibited significantly higher physical activity levels (98.6% meeting guidelines compared to 55.6% of non-athletes; p < 0.001) and lower BMI (23.64 +/- 5.39 versus 29.69 +/- 8.34 kg/m(2); p < 0.001). Additionally, a greater proportion of athletes reported consuming fruit on five or more days per week (54.3% versus 33.3%; chi(2) = 8.10, p = 0.017; V = 0.26). Athletes reported shorter average sleep duration (9.06 +/- 3.67 versus 11.28 +/- 3.52 h per day; p = 0.001), although both groups exceeded the minimum recommended 8 h. No significant difference was observed between groups in daily screen time (4.04 +/- 2.63 versus 4.44 +/- 3.08 h; p = 0.44). In an exploratory regression model, frequency of energy drink consumption emerged as the only significant individual predictor of BMI (B = 4.12, 95% CI: 0.32-7.92; p = 0.034), although the overall model was not statistically significant (R (2) = 0.071; F = 1.26; p = 0.278). CONCLUSION: Participation in organized sports is linked to increased physical activity, lower body mass index, and improved fruit consumption among Saudi male adolescents. However, athletes reported reduced sleep duration, and elevated screen time persisted in both groups. These results support the integration of sports programs into adolescent health strategies and highlight the need for comprehensive interventions that address sleep hygiene, screen time management, and the promotion of physical activity. CI - Copyright (c) 2026 Bin Radhyan, Tomar, Bursais and Alaqil. FAU - Bin Radhyan, Fahad AU - Bin Radhyan F AD - Department of Physical Education, College of General Studies, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia. FAU - Tomar, Rakesh AU - Tomar R AD - Department of Physical Education, College of General Studies, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia. FAU - Bursais, Abdulmalek K AU - Bursais AK AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia. FAU - Alaqil, Abdulrahman I AU - Alaqil AI AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Adolescent MH - Saudi Arabia MH - Cross-Sectional Studies MH - Sleep Duration MH - *Exercise MH - *Athletes/statistics & numerical data MH - *Feeding Behavior MH - *Screen Time MH - Surveys and Questionnaires MH - Sedentary Behavior MH - *Diet/statistics & numerical data MH - Life Style MH - Body Mass Index MH - *Sleep PMC - PMC13341710 OTO - NOTNLM OT - Saudi Arabia OT - adolescents OT - body mass index OT - dietary habits OT - physical activity OT - sedentary behavior OT - sleep duration COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:32 MHDA- 2026/07/09 06:33 PMCR- 2026/06/24 CRDT- 2026/07/09 04:46 PHST- 2026/05/03 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/05/30 00:00 [accepted] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 04:46 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1871762 [doi] PST - epublish SO - Front Public Health. 2026 Jun 24;14:1871762. doi: 10.3389/fpubh.2026.1871762. eCollection 2026. PMID- 42422420 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Sex differences in the predictive value of insulin resistance surrogate indicators for prediabetes among Chinese adults aged 18-45 years: a multicenter cohort study. PG - 1872088 LID - 10.3389/fendo.2026.1872088 [doi] LID - 1872088 AB - OBJECTIVE: The aim of this study was to evaluate and compare the predictive value of four insulin resistance (IR) surrogate indices for incident prediabetes and examine sex-specific disparities in their predictive performance. METHODS: This multicenter retrospective cohort study enrolled 63,795 adults aged 18-45 years (51.2% male) with normoglycemia at baseline from the Rich Healthcare Group Database (2010-2016). Participants were followed for a median of 2.97 years. Cox proportional hazards regression models, restricted cubic spline analyses, and receiver operating characteristic (ROC) curve analysis were employed to assess associations and discriminative performance. Statistical analyses were conducted using R software and EmpowerStats. RESULTS: During follow-up, 5,304 (8.31%) participants developed prediabetes, with a significantly higher incidence in men than in women (10.76% vs. 5.74%; p< 0.001). After multivariable adjustment, all four IR indices were independently associated with incident prediabetes. Sex-stratified analyses demonstrated markedly stronger associations in women, particularly for metabolic score for insulin resistance (METS-IR) [fully adjusted hazard ratio (HR): 7.82, 95% confidence interval (CI): 5.81-10.51 vs. 1.45, 95% CI: 1.18-1.77 in men]. Triglyceride-glucose-body mass index (TyG-BMI) demonstrated the highest predictive accuracy in the overall population [area under the curve (AUC) = 0.6497], and women exhibited superior discriminative performance across all indices compared to men. CONCLUSION: IR surrogate indices demonstrate significantly greater predictive value for prediabetes in young Chinese women than in men, with METS-IR exhibiting the most pronounced sex disparity. These findings support sex-specific risk stratification using routine IR surrogate indices in prediabetes screening. CI - Copyright (c) 2026 Chang, Zhang, UmarShinge, Gu, Zhou, Zhang, Zhang, Zhang, Liu and Yang. FAU - Chang, Yafei AU - Chang Y AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Zhang, Luming AU - Zhang L AD - Department of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China. FAU - UmarShinge, Shafiu Adam AU - UmarShinge SA AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Gu, Rui AU - Gu R AD - Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. FAU - Zhou, Xingchao AU - Zhou X AD - Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. FAU - Zhang, Qingzhou AU - Zhang Q AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Zhang, Xinyi AU - Zhang X AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Zhang, Binbin AU - Zhang B AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Liu, Jiawei AU - Liu J AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Yang, Yanqi AU - Yang Y AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. AD - Department of Cardiothoracic and Vascular Surgery, University Hospital, Linkoping University, Linkoping, Sweden. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260624 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - Chinese people SB - IM MH - Humans MH - *Prediabetic State/epidemiology/diagnosis/metabolism MH - Female MH - *Insulin Resistance MH - Male MH - Adult MH - Retrospective Studies MH - China/epidemiology MH - Young Adult MH - Middle Aged MH - Adolescent MH - *Biomarkers MH - Predictive Value of Tests MH - Sex Factors MH - Follow-Up Studies MH - Blood Glucose/analysis MH - Incidence MH - Sex Characteristics MH - East Asian People PMC - PMC13341433 OTO - NOTNLM OT - Chinese population OT - METS-IR OT - TyG index OT - insulin resistance OT - sex differences COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:33 MHDA- 2026/07/09 06:34 PMCR- 2026/06/24 CRDT- 2026/07/09 04:42 PHST- 2026/05/04 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/09 06:34 [medline] PHST- 2026/07/09 06:33 [pubmed] PHST- 2026/07/09 04:42 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fendo.2026.1872088 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jun 24;17:1872088. doi: 10.3389/fendo.2026.1872088. eCollection 2026. PMID- 42421808 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260709 LR - 20260813 IS - 2468-4481 (Electronic) IS - 2468-4481 (Linking) VI - 11 IP - 7 DP - 2026 Jul TI - Endoscopic salvage for afferent loop syndrome: the antegrade lumen-apposing metal stent technique. PG - 298-303 LID - 10.1016/j.vgie.2026.01.007 [doi] AB - BACKGROUND AND AIMS: Afferent loop syndrome (ALS) is a rare postgastrectomy condition with biliopancreatic limb obstruction. Revision surgery carries high morbidity in patients with hostile anatomy. We aimed to demonstrate the feasibility of a double-scope, antegrade EUS-guided lumen-apposing metal stent (LAMS) enteroenterostomy as an endoscopic alternative in the management of complex ALS. METHODS: A patient with extensive prior gastric surgery presented with ALS. With a double-scope antegrade technique, a pediatric gastroscope (GIF-XP190 N; Olympus, Tokyo, Japan) was used to cannulate the afferent limb to place a guidewire, and a linear echoendoscope (GF-UCT180; Fujifilm, Tokyo, Japan) was advanced into the blind loop. The pediatric gastroscope was reintroduced into the efferent limb, which was water-distended to approximately 3 cm in diameter to achieve sonographic apposition. Under combined EUS and fluoroscopic guidance, a 15- x 15-mm electrocautery-enhanced LAMS (Boston Scientific, Marlborough, Mass, USA) was deployed to create an enteroenterostomy. RESULTS: Postdeployment contrast confirmed optimal position and immediate patency without leak. Symptoms resolved rapidly; the patient resumed a diet within days and gained weight. Abdominal radiography showed progressive LAMS expansion without adverse events. CONCLUSIONS: Double-scope antegrade EUS-guided LAMS placement safely decompressed the afferent limb in our patient, restoring enteral flow and avoiding high-morbidity reoperation. This technique merits consideration within multidisciplinary care and warrants larger comparative studies to define long-term outcomes. CI - (c) 2026 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. FAU - Ang, Nicholas Ken Jin AU - Ang NKJ AD - Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore. FAU - Lim, Jie Qi AU - Lim JQ AD - Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore. FAU - Lye, Tiffany Jian Ying AU - Lye TJY AD - Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore. FAU - Tan, Damien Meng Yew AU - Tan DMY AD - Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore. FAU - Lim, Chin Hong AU - Lim CH AD - Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore. LA - eng PT - Journal Article DEP - 20260205 PL - United States TA - VideoGIE JT - VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy JID - 101719677 PMC - PMC13343362 COIS- All authors disclosed no financial relationships. EDAT- 2026/07/09 06:32 MHDA- 2026/07/09 06:33 PMCR- 2026/02/05 CRDT- 2026/07/09 04:35 PHST- 2025/09/24 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 04:35 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - S2468-4481(26)00022-6 [pii] AID - 10.1016/j.vgie.2026.01.007 [doi] PST - epublish SO - VideoGIE. 2026 Feb 5;11(7):298-303. doi: 10.1016/j.vgie.2026.01.007. eCollection 2026 Jul. PMID- 42421701 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260709 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Health-related quality of life in children and adolescents with primary hypertension: a hospital-based cross-sectional study. PG - 1763465 LID - 10.3389/fpsyg.2026.1763465 [doi] LID - 1763465 AB - INTRODUCTION: Primary hypertension in childhood is increasingly recognized as an important health issue, but its impact on health-related quality of life (HRQoL) has not been well studied. METHODS: In this cross-sectional study conducted at the Pediatric Nephrology Department of Ege University Medical Center between June and December 2021, the Pediatric Quality of Life Inventory (PedsQL) 4.0 was administered face-to-face to 22 children and adolescents with primary hypertension and 31 healthy controls, along with their parents. Data were analyzed using IBM SPSS version 26. RESULTS: A total of 53 children and their parents were included. Compared with healthy controls, the primary hypertension group demonstrated significantly lower parent-reported physical health total scores, parent total PedsQL scores, and child physical health total scores. No statistically significant differences were observed between the groups in several other PedsQL subdomains. No significant differences were found in HRQoL scores according to BMI groups or treatment types. CONCLUSION: Children and adolescents with primary hypertension demonstrated lower health-related quality of life scores, particularly in physical health-related domains, compared with healthy controls. These findings suggest that primary hypertension may be associated with impaired quality of life in pediatric patients. Larger, multicenter, longitudinal studies are needed to validate these results. CI - Copyright (c) 2026 Topcak, Bulut Demir, Taner, Tosyali, Keskinoglu, Kabasakal and Kaplan Bulut. FAU - Topcak, Asli Berivan AU - Topcak AB AD - Department of General Pediatrics, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Bulut Demir, Melek Hande AU - Bulut Demir MH AD - Department of Child and Adolescent Psychiatry, Ministry of Health Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, Izmir, Turkiye. FAU - Taner, Sevgin AU - Taner S AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Tosyali, Merve AU - Tosyali M AD - Department of General Pediatrics, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Keskinoglu, Ahmet AU - Keskinoglu A AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Kabasakal, Caner AU - Kabasakal C AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Kaplan Bulut, Ipek AU - Kaplan Bulut I AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13341690 OTO - NOTNLM OT - PedsQL OT - adolescents OT - children OT - hypertension OT - quality of life COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 10:11 MHDA- 2026/07/09 10:12 PMCR- 2026/06/24 CRDT- 2026/07/09 04:34 PHST- 2025/12/08 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/09 10:12 [medline] PHST- 2026/07/09 10:11 [pubmed] PHST- 2026/07/09 04:34 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1763465 [doi] PST - epublish SO - Front Psychol. 2026 Jun 24;17:1763465. doi: 10.3389/fpsyg.2026.1763465. eCollection 2026. PMID- 42421482 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260826 IS - 1839-2628 (Electronic) IS - 1832-4274 (Linking) VI - 29 IP - 3 DP - 2026 Jun TI - Discrepancies in Crown-Rump Length and Abnormal Cord Insertion as Predictors of Selective Fetal Growth Restriction in Monochorionic Twin Pregnancies. PG - 183-188 LID - 10.1017/thg.2026.10079 [doi] AB - This study aims to explore the significance of discrepancies in crown-rump length (CRL) and abnormal cord insertion in predicting selective fetal growth restriction (sFGR) in monochorionic (MC) twin pregnancies. Special attention was paid to determining the potential value of these factors in early pregnancy for predicting sFGR. A retrospective analysis included 131 pregnant women diagnosed with MC twin pregnancies. CRL was measured using a GE E8 color Doppler ultrasound instrument. Groups were compared based on the discrepancy in CRL (>/=6 mm difference group, n = 26; <6 mm normal group, n = 105) and the presence of abnormal cord insertion (abnormal group, n = 27; normal group, n = 104). The study found no significant association between CRL discrepancy and postnatal birth-weight discordance suggestive of sFGR (p > .05). In contrast, abnormal cord insertion was significantly associated with an increased occurrence of sFGR-related outcome (p < .001). Specifically, sFGR-related outcome occurred in 12 of 27 cases (44.4%) in the abnormal cord insertion group, compared with 7 of 104 cases (6.7%) in the normal cord insertion group. In this retrospective MC twin cohort, abnormal cord insertion was associated with an increased risk of postnatal birth-weight discordance suggestive of sFGR, whereas CRL discrepancy showed limited discriminative ability. Because of the retrospective design, limited number of outcome events, and use of postnatal rather than standardized antenatal Doppler-based sFGR criteria, these findings should be interpreted as exploratory and require validation in larger prospective studies. FAU - Luo, Jing AU - Luo J AD - Jiaxing Maternity and Child Health Care Hospital, China. FAU - Xu, Ping AU - Xu P AD - Jiaxing Maternity and Child Health Care Hospital, China. FAU - Ai, Lin AU - Ai L AD - Jiaxing Maternity and Child Health Care Hospital, China. FAU - Feng, Ying AU - Feng Y AUID- ORCID: 0009-0001-8508-0059 AD - Jiaxing Maternity and Child Health Care Hospital, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260709 PL - England TA - Twin Res Hum Genet JT - Twin research and human genetics : the official journal of the International Society for Twin Studies JID - 101244624 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Fetal Growth Retardation/diagnostic imaging MH - *Crown-Rump Length MH - *Pregnancy, Twin MH - *Umbilical Cord/diagnostic imaging/abnormalities MH - Retrospective Studies MH - Ultrasonography, Prenatal MH - *Twins, Monozygotic MH - Adult MH - Birth Weight MH - Infant, Newborn OTO - NOTNLM OT - Abnormal cord insertion OT - Crown-Rump Length discrepancy OT - Early pregnancy prediction OT - Monochorionic twins OT - Selective Fetal Growth Restriction EDAT- 2026/07/09 06:32 MHDA- 2026/08/06 12:37 CRDT- 2026/07/09 03:23 PHST- 2026/08/06 12:37 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 03:23 [entrez] AID - S1832427426100796 [pii] AID - 10.1017/thg.2026.10079 [doi] PST - ppublish SO - Twin Res Hum Genet. 2026 Jun;29(3):183-188. doi: 10.1017/thg.2026.10079. Epub 2026 Jul 9. PMID- 42421336 OWN - NLM STAT- Publisher LR - 20260727 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Jul 9 TI - Dietary inflammation during pregnancy and later symptoms of offspring behavioural and emotional problems. PG - 1-10 LID - 10.1017/S0007114526107879 [doi] AB - The maternal diet is believed to influence child neurodevelopment, at least in part, through inflammation, as dietary components can have pro- or anti-inflammatory effects. We examined the association between the energy-adjusted dietary inflammatory index (E-DII) during pregnancy and offspring symptoms of behavioural and emotional problems at 5.5 and 10 years, using data from the French nationwide Etude Longitudinale Francaise depuis l'Enfance/French Longitudinal Study since Childhood (ELFE) birth cohort. Dietary intake during pregnancy was assessed using a validated FFQ, and an E-DII score was generated. Child behavioural and emotional symptoms, including hyperactivity-inattention, conduct, peer-relationship and emotional problems, were evaluated by parents using the Strengths and Difficulties Questionnaire at 5.5 (n 9627) and 10 years (n 8362) for hyperactivity-inattention, conduct, peer-relationship and emotional problems. Children were classified into three categories based on thresholds used to identify clinically relevant symptoms: 'Normal', 'Borderline' and 'Atypical'. Multinomial logistic regression adjusted for potential confounders was used to estimate OR and 95 % CI. An increasing maternal E-DII score during pregnancy was associated with higher odds of offspring classified with atypical hyperactivity-inattention and conduct problem scores at 5.5 and 10 years, atypical peer-relationship problem scores at 10 years and atypical emotional problem scores at 10 years (differentially by sex). A more pro-inflammatory diet during pregnancy was consistently associated with higher odds of symptoms of externalising problems throughout childhood and with internalising problems at 10 years. Future research should explore the mechanisms by which prenatal exposure to maternal diet-induced inflammation may contribute to these outcomes. FAU - Dow, Courtney AU - Dow C AUID- ORCID: 0000-0002-9925-8460 AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 FAU - Delvert, Rosalie AU - Delvert R AUID- ORCID: 0000-0002-1524-8071 AD - Universite Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Equipe d'Epidemiologie respiratorie integrative, CSEP, Villejuif, France. FAU - de Lauzon-Guillain, Blandine AU - de Lauzon-Guillain B AUID- ORCID: 0000-0001-5887-8842 AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 FAU - van der Waerden, Judith AU - van der Waerden J AD - Sorbonne Universite, Inserm, Institut Pierre Louis d'Epidemiologie et de Sante Publique (IPLESP), Equipe de Recherche en Epidemiologie Sociale (ERES), Paris, 75012, France. FAU - Davidovic, Laetitia AU - Davidovic L AD - Universite Cote d'Azur, CNRS UMR7275, Inserm U1323, Institut de Pharmacologie Molecularie et Cellulaire, Valbonne, France. FAU - Charles, Marie-Aline AU - Charles MA AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 FAU - Galera, Cedric AU - Galera C AD - University of Bordeaux, Inserm, Bordeaux Population Health Center, UMR 1219, Bordeaux, France. AD - Centre Hospitalier Charles Perrens, Bordeaux, France. AD - Unit on Children's Psychosocial Maladjustment, Montreal, Canada. FAU - Heude, Barbara AU - Heude B AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 LA - eng PT - Journal Article DEP - 20260709 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Behavioural problems OT - Dietary inflammatory index OT - Inflammation OT - Life course OT - Pregnancy OT - Prenatal environment EDAT- 2026/07/09 06:33 MHDA- 2026/07/09 06:33 CRDT- 2026/07/09 01:43 PHST- 2026/07/09 06:33 [pubmed] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 01:43 [entrez] AID - S0007114526107879 [pii] AID - 10.1017/S0007114526107879 [doi] PST - aheadofprint SO - Br J Nutr. 2026 Jul 9:1-10. doi: 10.1017/S0007114526107879. PMID- 42420938 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261008 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 8 TI - Reproducibility of an 85-item Child Food Frequency Questionnaire (85-item Child-FFQ) and diet quality scores among Polish children: The cross-sectional PITNUTS 2024 study. LID - 10.1186/s12887-026-07222-6 [doi] LID - 949 AB - BACKGROUND: Early childhood nutrition is crucial for long-term health; however, assessing dietary intake in young children is challenging due to the reliance on parent/caregiver reporting and the need for culturally relevant tools. The aim of this study (the Polish Infant and Toddler Nutrition Study, PITNUTS 2024) was to address this gap by developing and evaluating the reproducibility of a new 85-item Child Food Frequency Questionnaire (85-item Child-FFQ) and associated diet quality scores for Polish children aged 13-72 months. METHODS: A cross-sectional, nationally representative sample of 700 Polish children from two age groups (13-36 and 37-72 months) was recruited, and 100 children were randomly selected from each age group for the reproducibility study. The 85-item Child-FFQ was administered twice to the same parent as a proxy reporter. Three diet quality scores were developed: the children's pro-Healthy Diet Score, the children's non-Healthy Diet Score, the children's Ultra-Processed Food Score. Statistical analyses included comparisons of mean values for food consumption frequency and diet quality scores, cross-classification, kappa statistic, intraclass correlation coefficient (ICC), Spearman's correlation, and Bland-Altman plots. RESULTS: The 85-item Child-FFQ showed good test-retest reproducibility. Classification agreement for food consumption frequency ranged from 74% to 97% for children aged 13-36 months, and 77% to 95% for children aged 37-72 months. The kappa statistic indicated moderate to excellent agreement between test and retest of the FFQ. Diet quality scores demonstrated high reproducibility, with classification agreement ranging from 77% to 92%, the kappa statistic ranging from 0.62 to 0.86, and good to excellent correlation coefficients (ICC: 0.886-0.950, Spearman's r: 0.889-0.947). The Bland-Altman analysis revealed a small negative shift between test and retest of the diet quality scores and moderately wide limits of agreement. CONCLUSIONS: The newly developed 85-item Child-FFQ is a reliable tool for assessing habitual food consumption frequency and diet quality in Polish children aged 13-72 months. This tool has the potential to help monitor food consumption and diet quality variations over time, though this capacity needs to be validated through future longitudinal studies. TRIAL REGISTRATION: This trial was registered at www. CLINICALTRIALS: gov (NCT06417151, 16th May 2024). CI - (c) 2026. The Author(s). FAU - Sawicki, Michal AU - Sawicki M AD - Nutricia Foundation, 8 Bobrowiecka Street, Warsaw, 00-728, Poland. FAU - Kowalkowska, Joanna AU - Kowalkowska J AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, Olsztyn, 10-718, Poland. joanna.kowalkowska@uwm.edu.pl. FAU - Weker, Halina AU - Weker H AD - Department of Nutrition, Institute of Mother and Child, 17a Kasprzaka Street, Warsaw, 01-211, Poland. FAU - Wadolowska, Lidia AU - Wadolowska L AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, Olsztyn, 10-718, Poland. LA - eng SI - ClinicalTrials.gov/NCT06417151 GR - RG 1/2023/Nutricia Foundation/ PT - Journal Article PT - Observational Study DEP - 20260708 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Cross-Sectional Studies MH - *Diet MH - *Diet Surveys/methods MH - *Feeding Behavior MH - Poland MH - Reproducibility of Results MH - Surveys and Questionnaires PMC - PMC13640158 OTO - NOTNLM OT - Diet quality OT - Dietary assessment OT - Dietary pattern OT - Food frequency questionnaire OT - Nutrition OT - Preschoolers OT - Reliability OT - Reproducibility OT - Toddlers OT - Ultra-processed food COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of the Institute of Mother and Child in Warsaw (ethics approval number: 40/2024). Informed consent was obtained from all parents-proxies involved in the study. Consent for publication: Not applicable. Competing interests: MS is an employee of the Nutricia Foundation that sponsored this study. EDAT- 2026/07/09 06:32 MHDA- 2026/10/06 05:29 PMCR- 2026/07/08 CRDT- 2026/07/09 00:19 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/10/06 05:29 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 00:19 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.1186/s12887-026-07222-6 [pii] AID - 7222 [pii] AID - 10.1186/s12887-026-07222-6 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 8;26(1):949. doi: 10.1186/s12887-026-07222-6. PMID- 42420921 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 9 TI - Effectiveness and implementation of an intervention strategy-based health promoting schools framework to reduce idiopathic scoliosis and myopia among children and adolescents in Shanghai, China: study protocol. LID - 10.1186/s12889-026-28184-5 [doi] LID - 2865 AB - BACKGROUND: Idiopathic scoliosis (IS) and myopia have emerged as major public health concerns affecting children and adolescents worldwide, with a confirmed comorbid association. Both conditions share common risk factors, including outdoor activity, sedentary behaviour, screen time, and sleep duration. This protocol describes a study designed to evaluate the effectiveness of the "ATPISM" intervention strategy, which is developed based on the six core characteristics of the Health Promoting School (HPS) framework advocated by the World Health Organization (WHO). Appropriate Techniques for the Prevention of Idiopathic Scoliosis and Myopia (ATPISM) aim to establish a comprehensive preventive intervention strategy against idiopathic scoliosis and myopia within the HPS framework, and to assess and explore the implementation of ATPISM across five dimensions: acceptability, feasibility, adoption, usage, and maintenance. METHODS AND ANALYSIS: This is a two-phase hybrid type I effectiveness implementation trial. A 1:1 parallel-group cluster randomized controlled trial will be conducted in 30 schools (15 intervention, 15 control) across three districts in Shanghai, involving approximately 5964 students. The primary outcomes will include differences in IS and myopia screening positivity rates, body composition and behavioral indicators among children and adolescents. Secondary outcomes will assess the Reach, Effectiveness, Adoption, Implementation, and Maintenance of the ATPISM intervention using the RE-AIM framework. To account for school clustering effects, mixed-effects models will be developed to compare group differences. Subgroup analyses will be conducted to identify interaction effects (stratification factorxgroup) and examine differences in intervention effects across strata. Additionally, Difference in Differences (DID) analysis will be employed. DISCUSSION: This study is the first to apply the HPS framework for concurrent prevention of IS and myopia in China. The ATPISM strategy, centered on schools and supported by families and communities, is expected to reduce IS and myopia prevalence and improve health behaviors. Findings will provide evidence-based insights for scaling up HPS in China and offer a replicable model for global adolescent health promotion, safeguarding the physical and mental well-being of children and adolescents. TRIAL REGISTRATION: ChiCTR2600117433. Registered January 23, 2026. CI - (c) 2026. The Author(s). FAU - Zhang, Tongtong AU - Zhang T AD - Chongming Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 202150‌, China. AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Li, Xin AU - Li X AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. AD - Children's Rehabilitation Innovation and Transformation Research Center of Yuanshen Rehabilitation Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. FAU - Liang, Juping AU - Liang J AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Fan, Qimeng AU - Fan Q AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Yang, Xiaoyan AU - Yang X AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Lu, Huan AU - Lu H AD - Shanghai Chongming District Center for Disease Control and Prevention, Shanghai, 202162, China. FAU - Yuan, Haiyan AU - Yuan H AD - Chongming Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 202150‌, China. FAU - Wu, Fan AU - Wu F AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Huang, Yongfang AU - Huang Y AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Du, Xueli AU - Du X AD - Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. dxl0405@163.com. FAU - Du, Qing AU - Du Q AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. duqing@xinhuamed.com.cn. AD - Children's Rehabilitation Innovation and Transformation Research Center of Yuanshen Rehabilitation Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. duqing@xinhuamed.com.cn. LA - eng GR - 202540012/Shanghai Municipal Health Commission Special Clinical Research Program in the Health Sector/ GR - ZKXM2502-03/Think Tank Research Projects of the Institute of Health Governance, Shanghai University of Medicine & Health Sciences/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260709 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Myopia/prevention & control/epidemiology MH - Adolescent MH - China/epidemiology MH - *Scoliosis/prevention & control/epidemiology MH - Child MH - *Health Promotion/organization & administration/methods MH - Female MH - *School Health Services/organization & administration MH - Randomized Controlled Trials as Topic MH - Male MH - Program Evaluation PMC - PMC13647753 OTO - NOTNLM OT - Children and adolescents OT - Cluster randomized controlled trial OT - Health Promoting Schools OT - Idiopathic scoliosis OT - Myopia COIS- Declarations. Ethics approval and consent to participate: This study was approved by the medical ethics committee of Shanghai University of Medicine and Health Sciences, Chongming Hospital (CMEC-2025-KT-51). This study adhered to ethical standards, obtaining informed consent from both participants and their parents. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/09 06:32 MHDA- 2026/10/08 05:31 PMCR- 2026/07/09 CRDT- 2026/07/09 00:18 PHST- 2026/01/25 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 00:18 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - 10.1186/s12889-026-28184-5 [pii] AID - 28184 [pii] AID - 10.1186/s12889-026-28184-5 [doi] PST - epublish SO - BMC Public Health. 2026 Jul 9;26(1):2865. doi: 10.1186/s12889-026-28184-5. PMID- 42420888 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261004 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Jul 8 TI - Diagnostic accuracy of the Fujifilm SILVAMP TB LAM II (FujiLAM II) assay for the diagnosis of childhood tuberculosis. LID - 10.1186/s12879-026-13992-2 [doi] LID - 1760 AB - BACKGROUND: Point-of-care tests (POCTs) are urgently needed to improve tuberculosis (TB) diagnosis in children. This study evaluated the diagnostic accuracy of the Fujifilm SILVAMP TB LAM II (FujiLAM II) assay for childhood TB diagnosis. METHODS: Spot urine samples were collected from children with TB (either bacteriologically confirmed or clinically diagnosed) and from healthy controls, then tested using FujiLAM II. Sensitivity was assessed against microbiological and clinical reference standards, while specificity was determined against healthy controls. RESULTS: Of 137 participants, 87 had TB and 50 were controls. FujiLAM II showed overall sensitivity of 17.2%, higher in bacteriologically confirmed cases (36.8%) than in clinically diagnosed cases (11.8%). Sensitivity was better in children under five (27.9%), HIV-positive children (25.0%), and underweight or stunted children (24.0%). Specificity was 100%. In the subgroup of 66 children tested with both assays, detection rates did not differ significantly (28.8% vs. 22.7%). When results from either test were considered positive, the detection rate increased to 40.9%, representing a 12.1% improvement over Xpert Ultra alone. CONCLUSION: FujiLAM II shows suboptimal sensitivity for childhood TB diagnosis, with better sensitivity in children under five years, HIV-positive, or malnourished, and may add value to current diagnostic algorithms. CI - (c) 2026. The Author(s). FAU - Ayalew, Sosina AU - Ayalew S AD - Armauer Hansen Research Institute, Addis Ababa, Ethiopia. absosina2011@gmail.com. AD - Department of Biology, College of Natural and Computational Sciences, Arba Minch University, Arba Minch, Ethiopia. absosina2011@gmail.com. FAU - Wegayehu, Teklu AU - Wegayehu T AD - Department of Biology, College of Natural and Computational Sciences, Arba Minch University, Arba Minch, Ethiopia. FAU - Neway, Sebsib AU - Neway S AD - Armauer Hansen Research Institute, Addis Ababa, Ethiopia. FAU - Adere, Tsion Seifu AU - Adere TS AD - Zewditu Memorial Hospital, Addis Ababa, Ethiopia. FAU - Tesfaye, Woinishet AU - Tesfaye W AD - Kidus Petros Hospital, Addis Ababa, Ethiopia. FAU - Berihun, Awokech AU - Berihun A AD - St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. FAU - Wondale, Biniam AU - Wondale B AD - Department of Biology, College of Natural and Computational Sciences, Arba Minch University, Arba Minch, Ethiopia. FAU - Piantadosi, Anne AU - Piantadosi A AD - Division of Infectious Diseases, Department of Pathology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. FAU - Tessema, Bamlak AU - Tessema B AD - Armauer Hansen Research Institute, Addis Ababa, Ethiopia. FAU - Mihret, Adane AU - Mihret A AD - Armauer Hansen Research Institute, Addis Ababa, Ethiopia. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260708 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Humans MH - Sensitivity and Specificity MH - Child, Preschool MH - Female MH - Male MH - *Tuberculosis/diagnosis/urine/microbiology MH - Child MH - Infant MH - *Mycobacterium tuberculosis/isolation & purification/genetics MH - Rapid Diagnostic Tests MH - Adolescent PMC - PMC13632158 OTO - NOTNLM OT - Childhood TB OT - FujiLAM II OT - Point-of-care tests COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/09 06:32 MHDA- 2026/10/03 08:38 PMCR- 2026/07/08 CRDT- 2026/07/09 00:16 PHST- 2026/01/27 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/10/03 08:38 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 00:16 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.1186/s12879-026-13992-2 [pii] AID - 13992 [pii] AID - 10.1186/s12879-026-13992-2 [doi] PST - epublish SO - BMC Infect Dis. 2026 Jul 8;26(1):1760. doi: 10.1186/s12879-026-13992-2. PMID- 42419862 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2632-1009 (Electronic) IS - 2632-1009 (Linking) VI - 33 IP - 1 DP - 2026 Jul 8 TI - Explainable machine learning revealing the impact of mental and physical health on arthritis. LID - 10.1136/bmjhci-2025-101955 [doi] LID - e101955 AB - OBJECTIVES: To develop a robust and interpretable machine learning framework for arthritis risk prediction and to identify important risk factors associated with the disease. METHODS: This study used four datasets, which are Behavioral Risk Factor Surveillance System (BRFSS) 2019, BRFSS 2021, National Health Interview Survey (NHIS) 2020 and NHIS 2022. We evaluated 11 machine learning and deep learning architectures including a custom stacked ensemble combined with five resampling techniques to address class imbalance and 9 imputation methods to handle missing data. Area under the receiver operating characteristic curve (AUROC), sensitivity, specificity and balanced accuracy are used to evaluate model performance, with fivefold cross-validation to ensure robustness. SHapley Additive exPlanations (SHAP) provided feature interpretability in prediction. RESULTS: The combination of the stacked ensemble, Generative Adversarial Network (GAN) imputation and random undersampling (RUS) achieved the best performance with an AUROC of 0.8007 and sensitivity of 0.8060 in the test set of BRFSS 2019. This combination also showed a balanced performance across both subgroups of male and female by maintaining high performance with AUROC of 0.808 and 0.800, respectively, in the test set of BRFSS 2021. The stacked ensemble model with GAN imputation and either Random Undersampling (RUS) or Random Oversampling (ROS) achieved the best performance across all four datasets. SHAP analysis identified higher age, walking difficulty and high body mass index (BMI) as the top physical factors. Among the psychosocial factors, parental separation showed a high impact on predicting arthritis. DISCUSSION: The risk of arthritis is influenced by health, lifestyle and childhood experiences. SHAP shows that difficulty walking, age, BMI and childhood stress play important roles in predicting arthritis risk. CONCLUSION: These results confirm important predictors of arthritis risk and provide a clear, interpretable framework. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Shams, Md Atik AU - Shams MA AUID- ORCID: 0009-0009-9984-058X AD - Department of Computer Science and Engineering, Notre Dame University Bangladesh, Dhaka, Bangladesh. AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Fatema, Sumaiya AU - Fatema S AUID- ORCID: 0009-0008-5662-314X AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Hasibul Islam, D M AU - Hasibul Islam DM AUID- ORCID: 0009-0002-0135-3169 AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Datta, Anindita AU - Datta A AD - Department of Fish and Wildlife Conservation, Virginia Tech, Blacksburg, Virginia, USA. FAU - Eisenberg, David AU - Eisenberg D AD - Department of Information Management and Business Analytics, Montclair State University, Montclair, New Jersey, USA. FAU - Tasaouf Mridula, Danastan AU - Tasaouf Mridula D AD - Department of Computer Science and Engineering, Northern University Bangladesh, Dhaka, Bangladesh. FAU - Mawa, Junnatul AU - Mawa J AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Sultana, Asma AU - Sultana A AUID- ORCID: 0009-0002-5306-5505 AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Ahmed, Nafiya AU - Ahmed N AD - Department of Computer Science, BRAC University, Dhaka, Bangladesh. FAU - Islam, Monowarul AU - Islam M AD - Department of Electrical and Electronic Engineering, Islamic University, Kushtia District, Bangladesh. FAU - Pias, Tanmoy Sarkar AU - Pias TS AUID- ORCID: 0000-0002-7325-9844 AD - Stanford Medicine, Stanford University, Stanford, California, USA tspias@stanford.edu. AD - Department of Computer Science, Virginia Tech, Blacksburg, Virginia, USA. LA - eng PT - Journal Article DEP - 20260708 PL - England TA - BMJ Health Care Inform JT - BMJ health & care informatics JID - 101745500 SB - IM MH - Humans MH - *Arthritis/epidemiology MH - *Machine Learning MH - Female MH - Risk Factors MH - Predictive Learning Models MH - *Mental Health MH - Male MH - *Health Status MH - Generative Adversarial Networks MH - Prediction Algorithms PMC - PMC13347896 OTO - NOTNLM OT - Artificial intelligence OT - BMJ Health Informatics OT - Public health informatics COIS- Competing interests: None declared. EDAT- 2026/07/09 04:10 MHDA- 2026/07/09 04:11 PMCR- 2026/07/08 CRDT- 2026/07/08 21:02 PHST- 2025/12/11 00:00 [received] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/07/09 04:11 [medline] PHST- 2026/07/09 04:10 [pubmed] PHST- 2026/07/08 21:02 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - bmjhci-2025-101955 [pii] AID - 10.1136/bmjhci-2025-101955 [doi] PST - epublish SO - BMJ Health Care Inform. 2026 Jul 8;33(1):e101955. doi: 10.1136/bmjhci-2025-101955. PMID- 42419449 OWN - NLM STAT- Publisher LR - 20260716 IS - 1531-5037 (Electronic) IS - 0022-3468 (Linking) DP - 2026 Jul 8 TI - Assessing pediatric frailty: Use of the surgical complication index for pediatric patients (SCIPP) score to predict adverse outcomes following thoracic surgery. PG - 163288 LID - S0022-3468(26)00370-2 [pii] LID - 10.1016/j.jpedsurg.2026.163288 [doi] AB - INTRODUCTION: The Surgical Complication Index for Pediatric Patients (SCIPP) score, validated for use in pediatric neurosurgery, assesses seven components of frailty for a composite score: independence in performing activities of daily living (ADLs), autonomic function, body mass index (BMI), continence, previous admissions, mobility, and polypharmacy, while a reduced SCIPP score utilizes ADLs, autonomic function, and polypharmacy components. This study aimed to understand the predictive performance of full and reduced SCIPP score in children undergoing thoracic operations. METHODS: A single-center retrospective review of patients age 2-18 years undergoing thoracic surgery from 2020 to 2025 was conducted, excluding patients with missing components of SCIPP score. Full and reduced SCIPP scores were calculated. Operative details and postoperative outcomes with 1-month follow-up were collected. Multiple logistic regression assessed the association between SCIPP scores, complications, and length of stay (LOS). RESULTS: We included 317 patients. SCIPP scores were 0-1 in 70.7%, 2-3 in 18.0%, and 4+ in 11.4%. Logistic regression found that for every 1-point increase in full and reduced SCIPP scores, patients were 2.19 and 3.24 times more likely to have any complication, respectively (p < 0.001). LOS increased by 26% for each point greater in full SCIPP score and 44% for reduced SCIPP score (p < 0.001). CONCLUSION: The SCIPP score, a composite pediatric frailty index, can predict a patient's risk of complications and likelihood of increased LOS following thoracic surgery. There is a role for SCIPP score utilization, particularly the reduced score, in the preoperative setting to optimize parental counseling, risk assessment, and determination of prehabilitation needs. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Vincent, Sage A AU - Vincent SA AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA. Electronic address: Sage.Vincent@cuanschutz.edu. FAU - Easwaran, Lavanya AU - Easwaran L AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA; Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 13123 E 16th Avenue, Aurora CO 80045, USA. FAU - Tong, Suhong AU - Tong S AD - Research Outcomes in Children's Surgery, Center for Children's Surgery, Children's Hospital Colorado, 13123 E 16th Ave, Aurora CO 80045, USA. FAU - Diaz-Miron, Jose AU - Diaz-Miron J AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA. FAU - Khurana, Eeshan AU - Khurana E AD - Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St, Suite 100, Philadelphia PA 19107, USA. FAU - Mazzola, Catherine A AU - Mazzola CA AD - New Jersey Pediatric Neuroscience Institute, 131 Madison Ave, Morristown NJ 07960, USA. FAU - Acker, Shannon N AU - Acker SN AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - J Pediatr Surg JT - Journal of pediatric surgery JID - 0052631 SB - IM OTO - NOTNLM OT - Complications OT - Frailty OT - Frailty score OT - Length of stay OT - Thoracic surgery COIS- Conflicts of interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jose Diaz-Miron reports a relationship with MedCore Technologies Corporation that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/09 04:10 MHDA- 2026/07/09 04:10 CRDT- 2026/07/08 19:11 PHST- 2026/03/16 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/09 04:10 [pubmed] PHST- 2026/07/09 04:10 [medline] PHST- 2026/07/08 19:11 [entrez] AID - S0022-3468(26)00370-2 [pii] AID - 10.1016/j.jpedsurg.2026.163288 [doi] PST - aheadofprint SO - J Pediatr Surg. 2026 Jul 8:163288. doi: 10.1016/j.jpedsurg.2026.163288. PMID- 42419373 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260821 IS - 1439-1899 (Electronic) IS - 0174-304X (Linking) VI - 57 IP - 4 DP - 2026 Aug TI - Primary Headache in Children: Clinical Characteristics and Impact on School Functioning in a Low-Resource Country. PG - 280-285 LID - 10.1055/a-2886-4833 [doi] AB - BACKGROUND: Primary headaches in children impair daily functioning, yet data from Jordan, particularly regarding their effect on school functioning, have not been systematically evaluated. OBJECTIVE: The objective of this study is to assess the clinical characteristics of pediatric primary headaches in central Jordan and their association with school functioning. METHODS: A cross-sectional study included children aged 5 to 18 years diagnosed with primary headaches at three public hospitals. Data were collected using a structured, culturally adapted questionnaire incorporating items from the validated Arabic PedsQL 4.0 school-functioning scale. Descriptive, univariable, and multivariable analyses were performed to identify factors associated with impaired school functioning. RESULTS: A total of 147 children were included (51% male; 61.2% aged 10-14 years). Migraine was most common (60.5%), followed by tension-type headache (23.8%). Common triggers included stress, noise, and sleep disturbance. Unfavorable lifestyle factors-increased screen time, skipped meals, low hydration, and limited physical activity-were prevalent. More than 92% of participants had impairment in at least one school-functioning domain. Poor academic performance and lower parental education were significantly associated with lower scores. In multivariable analysis, poorer academic performance and lower paternal education remained independently associated with worse school-functioning scores, whereas headache type and frequency were not significant predictors. Most patients used simple analgesics (paracetamol in 93%), whereas migraine-specific rescue medications and preventive therapies were rarely used. CONCLUSION: Primary headaches in children are associated with substantial impairment in school functioning. Educational and family-related factors appear more influential than headache-specific variables. Addressing modifiable lifestyle and contextual factors may improve outcomes. CI - Thieme. All rights reserved. FAU - Abu Libdeh, Amal AU - Abu Libdeh A AUID- ORCID: 0000-0001-5409-0230 AD - The University of Jordan, School of Medicine, Department of Pediatrics, Jordan, Amman. FAU - Alsubehat, Lara AU - Alsubehat L AUID- ORCID: 0009-0007-3621-3971 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Tabbalat, Nada AU - Tabbalat N AUID- ORCID: 0009-0006-6376-8131 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Mraish, Shahed AU - Mraish S AUID- ORCID: 0009-0004-9804-9845 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Al-Nawaiseh, Noura AU - Al-Nawaiseh N AUID- ORCID: 0009-0006-7756-2548 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Arabiyat, Nadine AU - Arabiyat N AUID- ORCID: 0009-0008-2397-3178 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Elayyan, Mustafa AU - Elayyan M AUID- ORCID: 0009-0004-2465-4436 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Al-Daraghmeh, Mohammad AU - Al-Daraghmeh M AUID- ORCID: 0009-0002-0316-0192 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Hussein, Hani AU - Hussein H AUID- ORCID: 0009-0006-8108-8025 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Deameh, Mohammad AU - Deameh M AUID- ORCID: 0009-0005-6197-3273 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Alshadfan, Lina AU - Alshadfan L AUID- ORCID: 0000-0003-4832-5149 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Masri, Amira AU - Masri A AUID- ORCID: 0000-0001-6103-8713 AD - The University of Jordan, School of Medicine, Department of Pediatrics, Jordan, Amman. LA - eng PT - Journal Article DEP - 20260708 PL - Germany TA - Neuropediatrics JT - Neuropediatrics JID - 8101187 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - Jordan/epidemiology MH - Adolescent MH - Child, Preschool MH - *Migraine Disorders/epidemiology MH - *Tension-Type Headache/epidemiology MH - *Academic Performance MH - Developing Countries COIS- The authors declare that they have no conflict of interest. EDAT- 2026/07/09 00:40 MHDA- 2026/08/21 23:37 CRDT- 2026/07/08 19:03 PHST- 2026/08/21 23:37 [medline] PHST- 2026/07/09 00:40 [pubmed] PHST- 2026/07/08 19:03 [entrez] AID - 10.1055/a-2886-4833 [doi] PST - ppublish SO - Neuropediatrics. 2026 Aug;57(4):280-285. doi: 10.1055/a-2886-4833. Epub 2026 Jul 8. PMID- 42419163 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260812 IS - 1873-3360 (Electronic) IS - 0306-4530 (Linking) VI - 192 DP - 2026 Oct TI - Beyond a simple marker of stress: A multiverse analysis of biopsychosocial associations with hair cortisol and cortisone. PG - 107953 LID - S0306-4530(26)00213-1 [pii] LID - 10.1016/j.psyneuen.2026.107953 [doi] AB - BACKGROUND: Hair concentrations of cortisol and cortisone are increasingly used as potential biomarkers of chronic stress. However, their validity as indicators of psychosocial stress remains debated, as prior research shows variable associations with stress-related psychological and behavioral factors. This study systematically investigates a broad set of biopsychosocial correlates of hair glucocorticoids in young adults, leveraging a multiverse framework to evaluate the robustness of associations often reported as variable in prior work. METHODS: Using data from the Zurich Project on the Social Development from Childhood to Adulthood, a large community-based age cohort, we employed a multiverse analysis to explore relationships between more than 60 biological, psychological, and contextual variables and three hair-based outcomes (cortisol, cortisone, and a combined score of both) at ages 20 (n = 1,002) and 24 (n = 887). Specification curve analyses were performed on the full sample and separately by sex, systematically varying model choices (i.e., inclusion/exclusion of covariates). RESULTS: Hair characteristics (i.e., color, washing intensity, chemical treatment), sampling season, body mass index, and, among women, hormonal contraception, showed strong associations with glucocorticoids and were included as covariates. Sweating intensity was associated with glucocorticoids primarily in females, but not in males. Hair concentrations of drugs (i.e., Delta9-tetrahydrocannabinol, cocaine, 3,4-methylenedioxymethamphetamine [MDMA, "Ecstasy"], paracetamol) and the hormone testosterone were consistently linked to steroid outcomes. Several psychosocial factors were associated with hair glucocorticoids: migration background, perceived stress, symptoms of anxiety/depression, sports activity, and social exclusion. These factors exhibited stronger correlations with cortisol, while media use, aggression, and effective coping were more closely associated with cortisone. The combined steroid score mainly reflected associations detected for cortisol, but with weaker effect sizes. Associations varied descriptively by age and sex, with more associations detected in males at age 20 and in females at age 24. CONCLUSION: In cohort studies, corticosteroids in hair can reflect specific facets of psychosocial stress when critical confounders and sex are considered. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Janousch, Clarissa AU - Janousch C AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. Electronic address: clarissa.janousch@ki.se. FAU - Eggenberger, Lukas AU - Eggenberger L AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. FAU - Johnson-Ferguson, Lydia AU - Johnson-Ferguson L AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Suchtfachstelle Zurich, Zurich, Switzerland. FAU - Voegel, Clarissa D AU - Voegel CD AD - Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. FAU - Baumgartner, Markus R AU - Baumgartner MR AD - Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. FAU - Ribeaud, Denis AU - Ribeaud D AD - Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. FAU - Eisner, Manuel AU - Eisner M AD - Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Institute of Criminology, University of Cambridge, Cambridge, United Kingdom. FAU - Binz, Tina M AU - Binz TM AD - Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. FAU - Shanahan, Lilly AU - Shanahan L AD - Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Institute of Psychology, University of Zurich, Zurich, Switzerland. FAU - Quednow, Boris B AU - Quednow BB AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. LA - eng PT - Journal Article DEP - 20260703 PL - England TA - Psychoneuroendocrinology JT - Psychoneuroendocrinology JID - 7612148 RN - V27W9254FZ (Cortisone) RN - WI4X0X7BPJ (Hydrocortisone) RN - 0 (Biomarkers) RN - 0 (Glucocorticoids) SB - IM MH - Humans MH - *Cortisone/analysis/metabolism MH - Female MH - *Hair/chemistry MH - *Hydrocortisone/analysis/metabolism MH - Male MH - *Stress, Psychological/metabolism MH - Biomarkers/analysis MH - Young Adult MH - Cohort Studies MH - Glucocorticoids/analysis MH - Adult OTO - NOTNLM OT - Allostatic load OT - Deep phenotyping OT - Glucocorticoids OT - Hair cortisol OT - Inflammation OT - Specification curve analysis COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/09 04:10 MHDA- 2026/08/12 23:34 CRDT- 2026/07/08 18:09 PHST- 2026/01/20 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/12 23:34 [medline] PHST- 2026/07/09 04:10 [pubmed] PHST- 2026/07/08 18:09 [entrez] AID - S0306-4530(26)00213-1 [pii] AID - 10.1016/j.psyneuen.2026.107953 [doi] PST - ppublish SO - Psychoneuroendocrinology. 2026 Oct;192:107953. doi: 10.1016/j.psyneuen.2026.107953. Epub 2026 Jul 3. PMID- 42418514 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260903 IS - 1536-4844 (Electronic) IS - 1078-0998 (Print) IS - 1078-0998 (Linking) VI - 32 IP - 9 DP - 2026 Sep 1 TI - Metabolome remodeling with reverse-engineered exclusive enteral nutrition in children with active Crohn's disease. PG - 1683-1694 LID - 10.1093/ibd/izag095 [doi] AB - BACKGROUND: For children with Crohn's disease (CD), dietary therapy with exclusive enteral nutrition (EEN) is effective in achieving clinical and biochemical remission. We investigated changes in metabolites in multiple clinical sample types from children with CD following a whole foods-blended ("reverse-engineered") EEN formula and defined associations between these changes and remission. METHODS: Stool, urine, serum, and plasma from a prospective study of newly diagnosed pediatric patients with CD enrolled in a 4-week trial of reverse-engineered exclusive enteral nutrition (RE-EEN) were analyzed using mass spectrometry targeting aqueous metabolites, bile acids, and short-chain fatty acids. Principal component analysis, mixed-effects models, and exploratory multivariate approaches including random forest and partial least-squares discriminant analysis were used to identify patterns associated with diet and metabolite abundances. RESULTS: Fecal, urine, serum, and plasma metabolomes changed significantly during RE-EEN treatment from baseline. These global changes were largely driven by increases in amino acids and related metabolites and decreases in different amino acids and metabolites reflecting carbohydrate and purine metabolism, in all sample types. While global bile acid profiles changed with the RE-EEN diet, no changes in specific bile acid levels reached significance, and no changes were found in short-chain fatty acid concentrations. CONCLUSION: Metabolomic profiles for pediatric patients with CD changed broadly during RE-EEN, indicating that this therapy may modulate key systemic and gut-associated metabolic processes. The findings further suggest that the gut metabolic processes influenced by RE-EEN, and that contribute to clinical improvement, may differ from those impacted by commercial EEN diets. Further research is crucial to validate these findings, uncover causal relationships, and optimize dietary protocols to enhance therapeutic outcomes in CD. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Suskind, David L AU - Suskind DL AUID- ORCID: 0000-0002-3524-5150 AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Hoffman, Lucas R AU - Hoffman LR AUID- ORCID: 0000-0001-8864-6751 AD - Department of Microbiology, University of Washington, Seattle, WA 98195, United States. FAU - Lee, Dale AU - Lee D AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Verster, Adrian J AU - Verster AJ AD - Pythia Informatics, Ottawa, ON K1S 0S7, Canada. FAU - Zheng, Hengqi Betty AU - Zheng HB AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Francis, Kendra AU - Francis K AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Nuding, Mason AU - Nuding M AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Vanamala, Jairam AU - Vanamala J AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Wahbeh, Ghassan AU - Wahbeh G AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Purcell, Hayley AU - Purcell H AD - Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, United States. FAU - Djukovic, Danijel AU - Djukovic D AUID- ORCID: 0000-0001-5954-8810 AD - Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, United States. FAU - Raftery, Daniel AU - Raftery D AUID- ORCID: 0000-0003-2467-8118 AD - Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, United States. FAU - Hayden, Hillary S AU - Hayden HS AUID- ORCID: 0000-0001-7372-9853 AD - Department of Microbiology, University of Washington, Seattle, WA 98195, United States. LA - eng GR - Richards Family Foundation/ GR - K24HL141669/NH/NIH HHS/United States GR - P30 DK035816/DK/NIDDK NIH HHS/United States GR - K24HL141669/NH/NIH HHS/United States GR - P30 DK035816/NH/NIH HHS/United States PT - Journal Article PL - England TA - Inflamm Bowel Dis JT - Inflammatory bowel diseases JID - 9508162 RN - 0 (Bile Acids and Salts) RN - Pediatric Crohn's disease SB - IM MH - Humans MH - *Crohn Disease/therapy/metabolism MH - *Enteral Nutrition/methods MH - Female MH - Male MH - *Metabolome MH - Child MH - Prospective Studies MH - Adolescent MH - Bile Acids and Salts/metabolism MH - Food, Formulated MH - Feces/chemistry MH - Prognosis MH - Follow-Up Studies MH - Metabolomics PMC - PMC13533203 OAB - In children with active Crohn's disease, a whole-foods-based enteral diet (reverse-engineered exclusive enteral nutrition) induced remission and broadly altered metabolites in stool, urine, and blood. These findings suggest that reverse-engineered exclusive enteral nutrition influences distinct metabolic pathways compared with commercial formulas, highlighting potential for tailored nutrition. OABL- eng OTO - NOTNLM OT - Crohn's disease OT - exclusive enteral nutrition OT - metabolomics OT - nutrition COIS- D.L.S. has written Nutrition in Immune Balance (NIMBAL) Therapy: Using Diet to Treat Inflammatory Bowel Disease, a lay book on diet in inflammatory bowel disease; and served as a consultant for Abbott Nutrition and Nestle Health Sciences. All other authors disclose no conflicts. EDAT- 2026/07/08 22:41 MHDA- 2026/09/01 17:39 PMCR- 2027/07/08 CRDT- 2026/07/08 13:44 PHST- 2025/09/02 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/09/01 17:39 [medline] PHST- 2026/07/08 22:41 [pubmed] PHST- 2026/07/08 13:44 [entrez] PHST- 2027/07/08 00:00 [pmc-release] AID - 8728491 [pii] AID - izag095 [pii] AID - 10.1093/ibd/izag095 [doi] PST - ppublish SO - Inflamm Bowel Dis. 2026 Sep 1;32(9):1683-1694. doi: 10.1093/ibd/izag095. PMID- 42418464 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Development and psychometric evaluation of the Spanish Cooking Self-Efficacy Questionnaire (SCSEQ) for Spanish University Students. PG - e0352758 LID - 10.1371/journal.pone.0352758 [doi] LID - e0352758 AB - The transition to university is a critical life stage characterized by increased autonomy, identity exploration, and new social and environmental influences. During this period, university students often exhibit low adherence to dietary guidelines. Among the determinants influencing healthy eating, cooking self-efficacy, the central construct of Social Cognitive Theory (SCT), is consistently associated with improved diet quality and is a frequent target of health interventions. However, no validated instrument exists to assess this construct among university students in Spain. Therefore, the goal was to develop and provide preliminary evidence of the Spanish Cooking Self-Efficacy Questionnaire (SCSEQ), a concise SCT-based instrument tailored to Mediterranean university settings. A 32-item questionnaire was developed through a review of existing instruments assessing cooking self-efficacy. Face validity was evaluated with Spanish food and nutrition experts (n = 12) to assess the clarity and pertinence of the initial items. The revised Spanish Cooking Self-Efficacy Questionnaire (SCSEQ) was then pilot-tested with Spanish university students (n = 73) from four Catalan universities. Exploratory factor analysis (EFA) was conducted to identify the underlying factor structure and detect problematic items. Internal consistency reliability was assessed using McDonald's omega, and test-retest reliability over a two-week interval was evaluated using Pearson correlations. Face validity indicated overall clarity and adequacy. Four items were excluded and recombined, two items were added, and nine items were rewritten based on experts' feedback. After pilot testing, the questionnaire overall demonstrated high internal consistency (omega = 0.9). Items were reviewed based on factor loadings, item redundancy, theoretical relevance, and their contribution to scale-level internal consistency. EFA suggested a two-factor structure with good internal consistency (omega = 0.88 and omega = 0.82) and test-retest reliability (ICC = 0.91, 95% CI [0.80, 0.96]). Three items with weak loadings were excluded. The final version consisted of 25 items and 2 subscales. The SCSEQ showed favorable preliminary psychometric properties. CI - Copyright: (c) 2026 Jurado-Gonzalez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Jurado-Gonzalez, Patricia AU - Jurado-Gonzalez P AUID- ORCID: 0000-0003-0632-0390 AD - NUTRALiSS, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Medina, F Xavier AU - Medina FX AUID- ORCID: 0000-0002-8067-355X AD - Epi4Health Research Group, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. AD - UNESCO Chair on Food, Culture and Development, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Martinez-Garcia, Alba AU - Martinez-Garcia A AD - Department of Community Nursing, Preventive Medicine, Public Health and History of Science, University of Alicante, Alicante, Spain. FAU - Lopez-Cediel Verdu, Almudena AU - Lopez-Cediel Verdu A AD - Talent Data Scientist, Data Scientist and Psychometric Specialist, Madrid, Spain. FAU - Fabregues, Sergi AU - Fabregues S AUID- ORCID: 0000-0003-1141-7613 AD - NUTRALiSS, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. AD - Department of Psychology and Education, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Bach-Faig, Anna AU - Bach-Faig A AD - NUTRALiSS, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Students/psychology MH - *Self Efficacy MH - *Psychometrics/methods MH - Female MH - Spain MH - *Cooking MH - Male MH - Universities MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Reproducibility of Results MH - Adolescent PMC - PMC13345255 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/08 18:52 MHDA- 2026/07/08 18:53 PMCR- 2026/07/08 CRDT- 2026/07/08 13:43 PHST- 2026/04/25 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/08 18:53 [medline] PHST- 2026/07/08 18:52 [pubmed] PHST- 2026/07/08 13:43 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - PONE-D-26-19104 [pii] AID - 10.1371/journal.pone.0352758 [doi] PST - epublish SO - PLoS One. 2026 Jul 8;21(7):e0352758. doi: 10.1371/journal.pone.0352758. eCollection 2026. PMID- 42418453 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Knowledge, attitudes, and practices regarding type 2 diabetes and associated factors among rural adolescents in Indonesia: A cross-sectional study. PG - e0352982 LID - 10.1371/journal.pone.0352982 [doi] LID - e0352982 AB - INTRODUCTION: Type 2 diabetes (T2D) is an increasingly important public health concern in Indonesia and is increasingly affecting adolescents at a growing rate due to lifestyle transitions and limited awareness. Evidence regarding adolescents' knowledge, attitudes, and practices (KAP) toward T2D in rural settings remains limited. This study assessed KAP levels related to T2D, identified sociodemographic factors associated with KAP outcomes, and examined interrelationships among KAP domains among rural Indonesian adolescents. METHODS: A cross-sectional study was conducted from September 2024 to February 2025 among 1,546 senior high school students in Kampar Regency, Riau Province. Participants were selected using multistage cluster sampling. Data were collected using a validated KAP questionnaire (Cronbach's alpha = 0.725). Descriptive and inferential statistics, including Mann-Whitney U tests, Kruskal-Wallis tests, Spearman's rank correlations, and multiple linear regression analyses, were used to examine KAP outcomes and associated factors. RESULTS: Participants demonstrated limited knowledge regarding T2D, particularly related to risk factors, symptoms, and complications. Although attitudes toward diabetes prevention were generally positive, preventive practices remained suboptimal, especially regarding physical activity. Female gender, peri-urban school location, higher academic rank, extracurricular participation, and prior exposure to diabetes information were associated with higher KAP scores. Knowledge was moderately associated with attitude but only weakly associated with preventive practices. CONCLUSIONS: Rural adolescents demonstrated limited diabetes-related knowledge and suboptimal preventive behaviors despite generally positive attitudes toward T2D prevention. Several sociodemographic and school-related factors were associated with KAP outcomes. However, the weak relationship between knowledge and practice highlights a persistent gap between awareness and preventive behavior. School-based, peer-led, and after-school interventions that integrate education with behavioral reinforcement may strengthen diabetes prevention efforts among rural adolescents. CI - Copyright: (c) 2026 Kusumawati et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kusumawati, Nila AU - Kusumawati N AUID- ORCID: 0000-0002-0967-228X AD - Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America. AD - Indonesian Diabetes Center, Universitas Pahlawan Tuanku Tambusai, Kampar, Riau Province, Indonesia. FAU - Pijl, Hanno AU - Pijl H AD - Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. FAU - Alaofe, Halimatou AU - Alaofe H AUID- ORCID: 0000-0002-3011-9673 AD - Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America. FAU - Yani, Emul AU - Yani E AD - Faculty of Nursing, Institut Kesehatan Payung Negeri Pekanbaru, Pekanbaru, Riau Province, Indonesia. FAU - Puswati, Desti AU - Puswati D AD - Faculty of Nursing, Institut Kesehatan Payung Negeri Pekanbaru, Pekanbaru, Riau Province, Indonesia. FAU - Hamid, Abdul AU - Hamid A AD - Indonesian Diabetes Center, Universitas Pahlawan Tuanku Tambusai, Kampar, Riau Province, Indonesia. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - *Health Knowledge, Attitudes, Practice MH - *Diabetes Mellitus, Type 2/epidemiology/prevention & control/psychology MH - Cross-Sectional Studies MH - Indonesia/epidemiology MH - Rural Population MH - Surveys and Questionnaires MH - Risk Factors PMC - PMC13345253 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/08 18:52 MHDA- 2026/07/08 18:53 PMCR- 2026/07/08 CRDT- 2026/07/08 13:43 PHST- 2025/11/27 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/08 18:53 [medline] PHST- 2026/07/08 18:52 [pubmed] PHST- 2026/07/08 13:43 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - PONE-D-25-61411 [pii] AID - 10.1371/journal.pone.0352982 [doi] PST - epublish SO - PLoS One. 2026 Jul 8;21(7):e0352982. doi: 10.1371/journal.pone.0352982. eCollection 2026. PMID- 42418153 OWN - NLM STAT- Publisher LR - 20260708 IS - 2042-7174 (Electronic) IS - 0961-7671 (Linking) DP - 2026 Jul 8 TI - Assessing confidence of community pharmacists in inflammatory bowel disease management: a cross-sectional study in Malta. LID - riag089 [pii] LID - 10.1093/ijpp/riag089 [doi] AB - OBJECTIVES: To evaluate community pharmacists' confidence in the management of inflammatory bowel disease (IBD) and to identify areas in which pharmacist-led patient education and counselling could be strengthened. METHODS: This cross-sectional study was conducted in three phases; questionnaire development and review by an expert panel, reliability assessment, and dissemination to 100 community pharmacies selected through stratified random sampling across Malta. Pharmacists' confidence across 29 items was assessed using mean rating scores (MRS) on a 5-point Likert scale. Non-parametric analyses examined associations between confidence, demographic variables, and perceived barriers (P < .05 statistically significant). KEY FINDINGS: Ninety-four pharmacists completed the questionnaire; female (n = 65), > 5 years of community pharmacy experience (n = 56), worked 31-40 hours weekly (n = 39), Master of Pharmacy degree (n = 47). 'High' confidence (MRS >/=4/5) was reported for advice on diet and lifestyle, non-prescription medicines for symptom management, medicine storage/stability, and recognizing when referral was required. 'Moderate' confidence (MRS 3 to <4/5) was observed for adherence support, relapse, counselling on extraintestinal complications, dosage form administration, corticosteroids, methotrexate, aminosalicylates, and biologics. 'Low' confidence (MRS <3/5) was identified for counselling on thiopurines, non-prescription medicines associated with toxic megacolon, vaccines, and pregnancy and women of child-bearing age. The main reported barriers to providing advice were time constraints (n = 70) and patient-related communication challenges (n = 63). Years of experience, hours of practice, and inadequate private consultation space were not significantly associated with pharmacist confidence (P > .05). CONCLUSIONS: Community pharmacists were more confident in general counselling and referral-related support than in medication-specific counselling and more complex aspects of IBD care. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Royal College of Pharmacy. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Diyab, Aisha AU - Diyab A AD - Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, MSD 2080, Malta. FAU - Wirth, Francesca AU - Wirth F AUID- ORCID: 0000-0002-3225-2363 AD - Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, MSD 2080, Malta. LA - eng PT - Journal Article DEP - 20260708 PL - England TA - Int J Pharm Pract JT - The International journal of pharmacy practice JID - 9204243 SB - IM OTO - NOTNLM OT - community pharmacy services OT - counselling OT - inflammatory bowel disease OT - patient education OT - pharmacists EDAT- 2026/07/08 12:57 MHDA- 2026/07/08 12:57 CRDT- 2026/07/08 11:23 PHST- 2025/09/24 00:00 [received] PHST- 2026/05/25 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/08 12:57 [medline] PHST- 2026/07/08 12:57 [pubmed] PHST- 2026/07/08 11:23 [entrez] AID - 8728405 [pii] AID - 10.1093/ijpp/riag089 [doi] PST - aheadofprint SO - Int J Pharm Pract. 2026 Jul 8:riag089. doi: 10.1093/ijpp/riag089. PMID- 42417998 OWN - NLM STAT- Publisher LR - 20260902 IS - 1432-198X (Electronic) IS - 0931-041X (Linking) DP - 2026 Jul 8 TI - Implementation and evaluation of a quality improvement project to standardize food insecurity screening in a pediatric nephrology clinic. LID - 10.1007/s00467-026-07443-y [doi] AB - BACKGROUND: Food insecurity is common among children with kidney disease and may worsen health outcomes. Implementation of screening in pediatric subspecialty clinics has not been well described. METHODS: Universal in-person screening was developed, implemented, and evaluated at one of the two primary pediatric nephrology clinics within an academic children's hospital in California and compared with a control clinic over a 16-month study period. At the intervention clinic, medical assistants and licensed vocational nurses screened all in-person visits using a two-question tool. The second clinic served as the control and continued usual care, in which selected patients were screened during multidisciplinary visits by a renal nurse, dietitian, or social worker. An interrupted time series analysis assessed changes in screening rates over time, and a difference-in-differences analysis compared trends between the intervention and control clinics. Implementation outcomes were evaluated using the RE-AIM framework. RESULTS: After implementation, screening rates in Clinic A (intervention clinic) increased immediately by 33%, followed by a modest but sustained upward trend of 1.0 percentage point per month. Screening completion was maintained, indicating successful integration into the clinic workflow. Staff initially reported discomfort performing screening due to uncertainty about how to respond to positive results; this improved after workflow refinements, including the introduction of a standardized script and the assignment of a nephrology-specific licensed vocational nurse to support follow-up. Caregivers reported high comfort with the screening process. CONCLUSIONS: Food insecurity screening was feasible and acceptable in a pediatric nephrology clinic, with clear workflows and defined roles supporting sustainability. CI - (c) 2026. The Author(s), under exclusive licence to International Pediatric Nephrology Association. FAU - Glenn Lecea, Eva M AU - Glenn Lecea EM AUID- ORCID: 0000-0003-2944-998X AD - Department of Pediatrics, University of California, San Francisco, USA. evaglennmd@gmail.com. FAU - Winnicki, Erica AU - Winnicki E AD - Department of Pediatrics, University of California, San Francisco, USA. FAU - Oates, Aris AU - Oates A AD - Department of Pediatrics, University of California, San Francisco, USA. FAU - Franzon, Deborah AU - Franzon D AD - Department of Pediatrics, University of California, San Francisco, USA. FAU - Evans, Jennifer AU - Evans J AD - Department of Medicine, University of California, San Francisco, USA. FAU - Plantinga, Laura AU - Plantinga L AD - Department of Medicine, University of California, San Francisco, USA. FAU - Tuot, Delphine S AU - Tuot DS AD - Department of Medicine, University of California, San Francisco, USA. LA - eng GR - P30HS029738/HS/AHRQ HHS/United States GR - P30HS029738/HS/AHRQ HHS/United States GR - P30HS029738/PCORI/Patient-Centered Outcomes Research Institute/United States PT - Journal Article DEP - 20260708 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 SB - IM OTO - NOTNLM OT - COM-B OT - Food insecurity screening OT - Implementation science OT - Pediatric nephrology clinic OT - Quality improvement OT - RE-AIM COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2026/07/08 12:55 MHDA- 2026/07/08 12:55 CRDT- 2026/07/08 11:13 PHST- 2026/03/17 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/05/07 00:00 [revised] PHST- 2026/07/08 12:55 [pubmed] PHST- 2026/07/08 12:55 [medline] PHST- 2026/07/08 11:13 [entrez] AID - 10.1007/s00467-026-07443-y [pii] AID - 10.1007/s00467-026-07443-y [doi] PST - aheadofprint SO - Pediatr Nephrol. 2026 Jul 8. doi: 10.1007/s00467-026-07443-y. PMID- 42417925 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261008 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 93 IP - 9 DP - 2026 Sep TI - A Simple Clinical Prediction Model for Metabolic Dysfunction-Associated Steatotic Liver Disease in Adolescents with Obesity. PG - 933-938 LID - 10.1007/s12098-026-06301-x [doi] AB - OBJECTIVES: To develop and validate a simple, office-based screening tool for metabolic dysfunction-associated steatotic liver disease (MASLD) in adolescents with obesity using readily available clinical indicators. METHODS: This cross-sectional study utilized NHANES 2021-2023 data (derivation cohort, n = 100) and 2017-2020 data (temporal validation cohort, n = 149). MASLD was defined as controlled attenuation parameter (CAP) >/=245 dB/m. Model performance was assessed using area under the receiver operating characteristic curve (AUC). RESULTS: A simplified three-variable model incorporating alanine aminotransferase (ALT), triglycerides, and waist circumference demonstrated excellent discrimination (AUC 0.809, 95% CI: 0.721-0.897) in derivation and remained robust in validation (AUC 0.725, 95% CI: 0.636-0.814). Inclusion of homeostasis model assessment of insulin resistance (HOMA-IR) did not significantly improve performance (DeLong P >0.05). CONCLUSIONS: This validated three-parameter model requires no specialized tests or insulin measurement, providing a practical tool for frontline pediatricians to stratify MASLD risk during routine visits. CI - (c) 2026. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - Liao, Yang AU - Liao Y AUID- ORCID: 0009-0002-9412-4487 AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. dr_liaoyang@163.com. FAU - Wang, Fei AU - Wang F AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. FAU - Tian, Ting-Ting AU - Tian TT AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. FAU - Li, Xiu-Fen AU - Li XF AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. LA - eng PT - Journal Article DEP - 20260708 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 RN - EC 2.6.1.2 (Alanine Transaminase) RN - 0 (Triglycerides) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Male MH - *Fatty Liver/diagnosis/etiology MH - Alanine Transaminase/blood MH - *Pediatric Obesity/complications MH - Triglycerides/blood MH - Insulin Resistance MH - Nutrition Surveys MH - Waist Circumference OTO - NOTNLM OT - Adolescent OT - Alanine aminotransferase OT - Metabolic dysfunction-associated steatotic liver disease OT - Pediatric obesity OT - Screening tool OT - Triglycerides OT - Waist circumference COIS- Declarations. Conflict of Interest: None. EDAT- 2026/07/08 12:56 MHDA- 2026/08/28 11:46 CRDT- 2026/07/08 11:06 PHST- 2026/02/19 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/07/08 12:56 [pubmed] PHST- 2026/07/08 11:06 [entrez] AID - 10.1007/s12098-026-06301-x [pii] AID - 10.1007/s12098-026-06301-x [doi] PST - ppublish SO - Indian J Pediatr. 2026 Sep;93(9):933-938. doi: 10.1007/s12098-026-06301-x. Epub 2026 Jul 8. PMID- 42416279 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2235-2988 (Electronic) IS - 2235-2988 (Linking) VI - 16 DP - 2026 TI - Rapid and low-cost detection of six major pediatric enteric pathogens using a closed-tube PCR-invasive reaction assay. PG - 1841155 LID - 10.3389/fcimb.2026.1841155 [doi] LID - 1841155 AB - Diarrhea caused by bacterial and viral pathogens remains a major cause of childhood morbidity and mortality, leading to dehydration, malnutrition, and substantial healthcare burdens; rapid and accurate diagnosis is therefore essential for timely treatment. In clinical practice, detection still commonly relies on traditional methods such as stool culture and enzyme-linked immunosorbent assays. These approaches are not only time-consuming and lack sensitivity but also typically require separate, pathogen-specific tests, complicating comprehensive diagnosis. While quantitative PCR (qPCR) offers speed and sensitivity, dye-based methods lack specificity, and fluorescent probe-based assays are costly. To address these limitations, we developed an integrated assay that combines PCR with a sequence-specific invasive reaction (Invader) in a single closed tube. This method detects six major pediatric enteric pathogens: Shigella spp., Vibrio cholerae, non-typhoidal Salmonella, Campylobacter jejuni, rotavirus, and enteric adenovirus (types 40/41). The assay demonstrated high sensitivity, with detection limits as low as 2 copies per reaction for each target and exhibited no cross-reactivity. The entire process was completed within 45 minutes. By employing universal Invader probes, we reduced the cost per test to approximately 2 RMB. Validation using both simulated and clinical stool samples suggested the assay's potential reliability and consistency with standard methods. This closed-tube PCR-Invader assay provides a rapid, cost-effective, and unified platform for the parallel detection of six major diarrheal pathogens in a single test run. It shows promise as a practical alternative to current disparate and pathogen-specific testing strategies, with considerable potential for use in primary healthcare settings and large-scale screening to guide the management of childhood infectious diarrhea. CI - Copyright (c) 2026 Yang, Zhou, Zhang, Huang, Kong, Zheng, Zhang, Shen, Han, Liu and Lu. FAU - Yang, Nan AU - Yang N AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhou, Jin AU - Zhou J AD - Department of Clinical Laboratory, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhang, Han AU - Zhang H AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Huang, Yihsuan AU - Huang Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Kong, Guiping AU - Kong G AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zheng, Yucan AU - Zheng Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhang, Zhuo AU - Zhang Z AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Shen, Ying AU - Shen Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Han, Xiu AU - Han X AD - School of Basic Medical Sciences, Faculty of Medicine, Yangzhou University, Yangzhou, China. FAU - Liu, Zhifeng AU - Liu Z AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Lu, Yan AU - Lu Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260623 PL - Switzerland TA - Front Cell Infect Microbiol JT - Frontiers in cellular and infection microbiology JID - 101585359 SB - IM MH - Humans MH - Sensitivity and Specificity MH - *Molecular Diagnostic Techniques/methods/economics MH - *Polymerase Chain Reaction/methods/economics MH - *Diarrhea/diagnosis/virology/microbiology MH - Campylobacter jejuni/isolation & purification/genetics MH - Feces/virology/microbiology MH - Rotavirus/isolation & purification/genetics MH - Vibrio cholerae/isolation & purification/genetics MH - Shigella/isolation & purification/genetics MH - Rapid Diagnostic Tests PMC - PMC13337639 OTO - NOTNLM OT - closed-tube assay OT - co-infection detection OT - enteric pathogens OT - invasive reaction OT - rapid and low-cost detection COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/08 06:52 MHDA- 2026/07/08 20:04 PMCR- 2026/06/23 CRDT- 2026/07/08 04:40 PHST- 2026/03/28 00:00 [received] PHST- 2026/05/31 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/08 20:04 [medline] PHST- 2026/07/08 06:52 [pubmed] PHST- 2026/07/08 04:40 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.3389/fcimb.2026.1841155 [doi] PST - epublish SO - Front Cell Infect Microbiol. 2026 Jun 23;16:1841155. doi: 10.3389/fcimb.2026.1841155. eCollection 2026. PMID- 42415596 OWN - NLM STAT- Publisher LR - 20260708 IS - 1540-8159 (Electronic) IS - 0147-8389 (Linking) DP - 2026 Jul 8 TI - Internal Jugular Vein as an Alternative Access for Pacemaker Implantation: A Mostly Left IJ Case Series. LID - 10.1111/pace.70358 [doi] AB - BACKGROUND: Leadless pacemakers traditionally rely on femoral venous access, which may be limited in patients with unfavorable IVC anatomy, prior interventions, or situations where preserving femoral access is preferred. Internal jugular (IJ) access offers an alternative route, but real-world data on IJ implantation of single- and dual-chamber leadless devices remain limited. OBJECTIVE: To describe patient characteristics, procedural details, and outcomes of pacemaker implantation via IJ access. METHODS: We performed a retrospective case series of five patients who underwent Abbott Aveir leadless pacemaker implantation-ventricular (VR), atrial (AR), or dual-chamber-via right and left IJ access at a single center. Demographics, indications, rationale for IJ access, procedural course, and acute device parameters were reviewed. Outcomes included procedural success, access-related complications, and device performance at discharge. RESULTS: All five patients (mean age 41+/- 21 years; 40% female; BMI 25.9 +/- 6.7 kg/m(2)) underwent successful IJ access implantation. Indications for pacemaker included intermittent complete heart block (n = 1), sinus node dysfunction (n = 4). Reasons for selecting IJ access included avoidance of femoral access in young active patients (n = 2), complex IVC anatomy with failed femoral advancement (n = 1), improved sheath control and trajectory for atrial leadless deployment (n = 1), and concern that patient could not tolerate post procedure precautions due to neurocognitive disorder. Acute device performance was favorable. VR devices demonstrated pacing thresholds 0.25-1.0 V @ 0.4 ms, R-wave amplitudes 8.9-17.9 mV, and impedance 410-910 Omega. AR devices showed thresholds 0.75-5.0 V @ 0.4 ms, P-wave amplitudes 0.5-4.4 mV, and impedance 320-910 Omega. Dual-chamber systems had stable parameters in both chambers. There were no intraprocedural or access-related complications, including no pneumothorax, hematoma, venous thrombosis, embolization, or hemodynamic instability. All patients had stable device function at discharge. CONCLUSION: IJ vein access is a feasible and safe alternative for pacemaker implantation in patients with limited femoral access, including pediatric and complex adult populations. This approach allows effective device placement and stable pacing outcomes, avoiding femoral-related vascular complications. Further studies are needed to validate reproducibility and long-term performance. CI - (c) 2026 The Author(s). Pacing and Clinical Electrophysiology published by Wiley Periodicals LLC. FAU - Takagi, Maya Asami AU - Takagi MA AUID- ORCID: 0000-0003-0032-1130 AD - Department of Internal Medicine, University of California Davis Health System, Sacramento, California, USA. FAU - Leon, William AU - Leon W AD - Division of Cardiovascular Medicine, University of California Davis Health System, Sacramento, California, USA. FAU - Mackenzie, Colin AU - Mackenzie C AD - Division of Cardiovascular Medicine, University of California Davis Health System, Sacramento, California, USA. FAU - Cortez, Daniel AU - Cortez D AUID- ORCID: 0000-0001-9874-0733 AD - Division of Pediatric Cardiology, University of California Davis Health System, Sacramento, California, USA. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - Pacing Clin Electrophysiol JT - Pacing and clinical electrophysiology : PACE JID - 7803944 SB - IM OTO - NOTNLM OT - Aveir pacemaker OT - alternative venous access OT - cardiac pacing OT - internal jugular vein OT - leadless pacemaker EDAT- 2026/07/08 06:52 MHDA- 2026/07/08 06:52 CRDT- 2026/07/08 03:13 PHST- 2026/06/05 00:00 [revised] PHST- 2026/04/27 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/08 06:52 [medline] PHST- 2026/07/08 06:52 [pubmed] PHST- 2026/07/08 03:13 [entrez] AID - 10.1111/pace.70358 [doi] PST - aheadofprint SO - Pacing Clin Electrophysiol. 2026 Jul 8. doi: 10.1111/pace.70358. PMID- 42415366 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1526-9914 (Electronic) IS - 1526-9914 (Linking) VI - 27 IP - 7 DP - 2026 Jul TI - Evaluating the correlation between pediatric exposure rates and common body size surrogates in fluoroscopy. PG - e70659 LID - 10.1002/acm2.70659 [doi] LID - e70659 AB - PURPOSE: To quantify the degree of correlation between pediatric radiation exposure rates and commonly used body size surrogates: anteroposterior (AP) or lateral (LAT) body thickness, weight, height, body mass index (BMI), body surface area (BSA), and age, for general fluoroscopy (GF) and cardiac fluoroscopically guided interventional (cardiac FGI) examinations, as a way to identify the most predictive surrogate to optimize dose management and exposure control across a wide range of pediatric body sizes. METHODS: This retrospective study included 6447 GF examinations, from 4452 pediatric patients, and 2968 cardiac FGI examinations, from 1471 patients, aged from birth to 21 years. Reference air kerma (RAK) data, collected from a radiation dose index monitoring database, were corrected using calibration measurements with accuracy better than +/- 5%. Exposure rate was calculated as RAK divided by total fluoroscopy time. Patient body size surrogates: measured AP or LAT thickness, age, weight, height, BMI, and BSA were extracted or computed from recorded data. Correlations between log-transformed exposure rates and body size surrogates were evaluated using Pearson's correlation coefficients. Steiger's Z-test was applied to assess statistically significant differences between dependent correlations. RESULTS: For GF examinations, AP thickness correlated most strongly with exposure rate (r = 0.691), followed by BSA (r = 0.574) and weight (r = 0.568). BMI showed the weakest correlation (r = 0.446). For cardiac FGI examinations, weight demonstrated the highest correlation with exposure rate in both frontal (r = 0.689) and LAT (r = 0.794) planes, with BSA and LAT thickness performing similarly. All other correlations were significantly lower (p < 0.001). The superior performance of AP thickness in GF reflects its direct relationship to X-ray attenuation, whereas variable geometry and positioning during cardiac FGI favor weight as a more stable predictor. CONCLUSIONS: For pediatric fluoroscopy, AP thickness best predicts exposure rate in GF, while weight is the most reliable surrogate for cardiac FGI procedures. Selecting modality-specific size metrics enhances pediatric dose optimization and supports consistent radiation exposure management across all patient sizes. CI - (c) 2026 The Author(s). Journal of Applied Clinical Medical Physics published by Wiley Periodicals, LLC on behalf of The American Association of Physicists in Medicine. FAU - Strauss, Keith J AU - Strauss KJ AD - Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - Department of Radiology, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA. FAU - Somasundaram, Elanchezhian AU - Somasundaram E AD - Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - Department of Radiology, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA. FAU - Meier, Joseph G AU - Meier JG AD - Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - Department of Radiology, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA. FAU - Brady, Samuel L AU - Brady SL AD - Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - Department of Radiology, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA. LA - eng PT - Journal Article PL - United States TA - J Appl Clin Med Phys JT - Journal of applied clinical medical physics JID - 101089176 SB - IM MH - Humans MH - Fluoroscopy/methods MH - Child, Preschool MH - Child MH - Adolescent MH - Infant MH - *Body Size MH - Retrospective Studies MH - Female MH - Male MH - Infant, Newborn MH - Radiation Dosage MH - Young Adult MH - Body Mass Index MH - Organs at Risk/radiation effects MH - *Radiation Exposure/analysis MH - Body Surface Area PMC - PMC13341963 OTO - NOTNLM OT - fluoroscopy OT - patient size metrics OT - pediatric OT - quality assurance OT - radiation dose OT - reference air kerma COIS- The authors declare no conflicts of interest EDAT- 2026/07/08 06:53 MHDA- 2026/07/08 18:50 PMCR- 2026/07/07 CRDT- 2026/07/08 01:13 PHST- 2026/03/30 00:00 [revised] PHST- 2025/12/08 00:00 [received] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/07/08 18:50 [medline] PHST- 2026/07/08 06:53 [pubmed] PHST- 2026/07/08 01:13 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - ACM270659 [pii] AID - 10.1002/acm2.70659 [doi] PST - ppublish SO - J Appl Clin Med Phys. 2026 Jul;27(7):e70659. doi: 10.1002/acm2.70659. PMID- 42415218 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260910 LR - 20260911 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Jul 7 TI - Prevalence and clinical correlates of avoidant/restrictive food intake disorder in children and adolescents with Celiac disease: a cross-sectional study. LID - 10.1186/s40337-026-01699-3 [doi] LID - 212 AB - BACKGROUND: Avoidant/Restrictive Food Intake Disorder (ARFID) may represent a clinically important problem in celiac disease (CD), where lifelong dietary restriction, ongoing gastrointestinal symptoms, and food-related anxiety may promote food avoidance beyond gluten-containing foods and contribute to maladaptive eating patterns. Although adult studies have reported high rates of ARFID symptoms in CD, pediatric data are limited. This study aimed to evaluate the prevalence and clinical correlates of ARFID in children and adolescents with CD using a multidisciplinary assessment approach involving pediatric gastroenterology and child and adolescent psychiatry specialists, including anthropometric, nutritional, bone health, psychological, and health-related quality-of-life (QoL) correlates. METHODS: A cross-sectional study was conducted at a tertiary-care center involving children and adolescents aged 8-17 years with biopsy-confirmed CD (n = 101). Participants were assessed using a combination of clinical interviews and psychometric scales, including the Nine Item ARFID Screen (NIAS), the Revised Child Anxiety and Depression Scale (RCADS), and the Pediatric QoL Inventory (PedsQL). ARFID diagnosis was established through a DSM-5-guided clinical evaluation by two child and adolescent psychiatrists, and clinical and anthropometric data were collected alongside laboratory results. Multivariable regression models were used to identify factors independently associated with ARFID and clinical outcomes. RESULTS: The prevalence of ARFID in the cohort was 42.6%. Children with ARFID exhibited significantly lower weight and BMI z-scores (p < 0.001 and p = 0.002, respectively), a higher prevalence of osteopenia/osteoporosis (p = 0.005) and micronutrient deficiencies (p < 0.001), poorer QoL (p < 0.001), and higher anxiety and depressive symptom scores (p < 0.001 and p = 0.003, respectively). Presence of gastrointestinal symptoms and higher anxiety score were independently associated with ARFID in children and adolescents with CD. CONCLUSION: In this cohort, ARFID appeared to be a clinically relevant comorbidity in pediatric CD, with adverse physical and psychosocial correlates. Restrictive eating extending beyond gluten avoidance should be recognized during clinical assessment, particularly in children with gastrointestinal symptoms, prominent anxiety symptoms, poor weight gain, or persistent micronutrient deficiencies. Longitudinal studies are needed to clarify the clinical course of ARFID symptoms and to inform targeted multidisciplinary care in this population. CI - (c) 2026. The Author(s). FAU - Teke, Halenur AU - Teke H AUID- ORCID: 0009-0001-0143-3890 AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. drhalenurteke@gmail.com. FAU - Sogut, Aydan AU - Sogut A AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Mavi, Hilal Tuter AU - Mavi HT AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Teke, Selcuk AU - Teke S AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Ergen, Yasin Maruf AU - Ergen YM AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Akcay, Birce Izgi AU - Akcay BI AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Celebi, Seda Bozduman AU - Celebi SB AD - Department of Child and Adolescent Psychiatry, Basaksehir Cam ve Sakura City Hospital, Istanbul, Turkiye. FAU - Congologlu, Mehmet Ayhan AU - Congologlu MA AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Balamtekin, Necati AU - Balamtekin N AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260707 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13556089 OAB - Celiac disease requires lifelong treatment with a strict gluten-free diet. In some children and adolescents, eating difficulties may extend beyond avoiding gluten and develop into avoidant/restrictive food intake disorder (ARFID), an eating disorder marked by very limited eating that is not driven by body image concerns. In celiac disease, ongoing digestive symptoms, fear of symptoms after gluten exposure, and the burden of following a strict diet may increase vulnerability to this problem. This study examined how common ARFID was in young people with celiac disease and explored its clinical features. ARFID was identified in 42.6% of the study group. Children and adolescents with ARFID had lower weight, more nutritional problems, weaker bone health, more anxiety and depression symptoms, and lower quality of life than those without ARFID. Ongoing gastrointestinal symptoms and higher anxiety symptoms were the factors most strongly linked with ARFID. These findings suggest that when food restriction extends beyond medically necessary dietary rules, it may indicate a more serious eating problem with both physical and emotional effects. Care for young people with celiac disease may benefit from a multidisciplinary approach that includes pediatric gastroenterology, child and adolescent psychiatry, dietetics, and psychological support. OABL- eng OTO - NOTNLM OT - Anxiety OT - Avoidant/Restrictive food intake disorder (ARFID) OT - Bone mineral density OT - Gluten-free diet OT - Pediatric celiac disease COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Scientific Research Ethics Committee of the University of Health Sciences, Gulhane Training and Research Hospital (Decision No: 2025/182, Decision Date: 11.09.2025). Written informed consent was obtained from all participants and their parents or legal guardians after providing a comprehensive explanation of the study aims and procedures. All study procedures adhered to the ethical standards set forth in the Declaration of Helsinki. Competing interests: The authors declare no competing interests. EDAT- 2026/07/08 02:00 MHDA- 2026/07/08 02:01 PMCR- 2026/07/07 CRDT- 2026/07/08 00:00 PHST- 2026/03/17 00:00 [received] PHST- 2026/06/27 00:00 [accepted] PHST- 2026/07/08 02:01 [medline] PHST- 2026/07/08 02:00 [pubmed] PHST- 2026/07/08 00:00 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - 10.1186/s40337-026-01699-3 [pii] AID - 1699 [pii] AID - 10.1186/s40337-026-01699-3 [doi] PST - epublish SO - J Eat Disord. 2026 Jul 7;14(1):212. doi: 10.1186/s40337-026-01699-3. PMID- 42415184 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260708 LR - 20260813 IS - 2056-7529 (Electronic) IS - 2056-7529 (Linking) VI - 12 IP - 1 DP - 2026 Jul 7 TI - Opportunities, challenges, and sustainability of lay co-research teams in low resource community settings in Sri Lanka. LID - 10.1186/s40900-026-00933-1 [doi] LID - 110 AB - BACKGROUND: Community-led research (CLR) positions community members as active partners in generating knowledge about issues affecting their wellbeing. This approach is grounded in the principle that those closest to a problem are best placed to identify meaningful and sustainable solutions. In Sri Lanka's plantation sector, families face persistent socio-economic and health inequities, including limited access to education, nutrition, and healthcare. The Women in Community Research (WinCR) group was established to address these challenges by enabling community members to lead research, document local realities, and translate evidence into advocacy to inform policy and practice. METHODS: In 2019, two community health and development practitioners established a voluntary lay co-researcher group, WinCR, consisting of 12 women from plantation communities with an interest in research. Participants were recruited through an open invitation. A structured capacity-building programme was implemented, covering qualitative research methods, advocacy, and skills such as communication and leadership. Learning was participatory and supported through peer mentoring and continuous feedback. The group applied these skills in a community-led study on maternal and child nutrition and later expanded their work to areas including school attendance, early literacy, and early childhood development. This paper outlines the establishment and sustainability of WinCR, as well as the key opportunities and challenges encountered from February 2019 to November 2025. RESULTS: CLR created several opportunities. The co-researchers' lived experiences improved the cultural relevance of research tools, strengthened rapport with participants, and increased acceptance of findings. Capacity-building enhanced confidence, leadership, and recognition, leading to collaborations with government, non-governmental, and academic institutions. Key challenges included the intensive facilitation required for adult learning, low digital literacy, limited access to research materials in local languages, and initial skepticism from some professionals. Maintaining objectivity was occasionally difficult due to personal connections to the research topics. Research engagement remained focused on health, nutrition, education, and child development. CONCLUSION: Establishing and sustaining a lay co-researcher team in a deprived community is both feasible and valuable. CLR enhances research relevance, community ownership, and advocacy while empowering participants with new skills. Despite challenges related to training, recognition, and technological limitations, the WinCR initiative demonstrates the potential of community-led research and offers a practical model for inclusive research in underserved settings. CI - (c) 2026. The Author(s). FAU - Jayasinghe, Rukmi Anuradha AU - Jayasinghe RA AD - Women in Community Research (WinCR), Deniyaya, Sri Lanka. rukmi.ajayasinghe@gmail.com. AD - Institute for Research & Development in Health & Social Care, Colombo, Sri Lanka. rukmi.ajayasinghe@gmail.com. FAU - Jayasinghe, Oshini Sri AU - Jayasinghe OS AD - Women in Community Research (WinCR), Deniyaya, Sri Lanka. AD - Institute for Research & Development in Health & Social Care, Colombo, Sri Lanka. AD - University of Liverpool, Liverpool, UK. FAU - Preethika, Sujani AU - Preethika S AD - Women in Community Research (WinCR), Deniyaya, Sri Lanka. FAU - Manamperi, Kusumalatha AU - Manamperi K AD - Women in Community Research (WinCR), Deniyaya, Sri Lanka. FAU - Kandambi, Ranjani AU - Kandambi R AD - Women in Community Research (WinCR), Deniyaya, Sri Lanka. LA - eng PT - Journal Article DEP - 20260707 PL - England TA - Res Involv Engagem JT - Research involvement and engagement JID - 101708164 PMC - PMC13339442 OTO - NOTNLM OT - Adult learning OT - Advocacy OT - Community empowerment OT - Community engagement & involvement in research (CEI) OT - Community-led research (CLR) OT - Health and social inequities OT - Lay co-researchers OT - Participatory approach OT - Women in research COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/08 04:10 MHDA- 2026/07/08 04:11 PMCR- 2026/07/07 CRDT- 2026/07/07 23:59 PHST- 2025/11/30 00:00 [received] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/07/08 04:11 [medline] PHST- 2026/07/08 04:10 [pubmed] PHST- 2026/07/07 23:59 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - 10.1186/s40900-026-00933-1 [pii] AID - 933 [pii] AID - 10.1186/s40900-026-00933-1 [doi] PST - epublish SO - Res Involv Engagem. 2026 Jul 7;12(1):110. doi: 10.1186/s40900-026-00933-1. PMID- 42414927 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261028 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 7 TI - A randomized clinical trial comparing the efficacy of probiotic drops and sucrose in managing colic in early infancy. LID - 10.1186/s12887-026-07271-x [doi] LID - 1057 AB - BACKGROUND AND AIM: Infantile colic, characterized by prolonged crying episodes in otherwise healthy infants, affects 10-40% of babies worldwide. Although self-limiting, it causes significant caregiver distress and disrupts infant development. Probiotics may alleviate colic symptoms by modulating gut microbiota and reducing inflammation, while sucrose has been shown to reduce crying by activating endogenous opioid pathways. This randomized controlled trial (RCT) compared the efficacy of Pedilact probiotic drops versus a 20% sucrose solution in managing colic. METHODS: A total of 120 breastfed infants aged 1-5 months with colic were randomly assigned to receive either Pedilact drops or 20% sucrose solution. Primary outcomes (feeding duration, crying hours, and sleep duration) were assessed at baseline and after 14 and 21 days of treatment. RESULTS: Significant differences were observed between the two groups in feeding duration, crying hours, and sleep duration at the 14- and 21-day follow-ups. However, both groups showed similar trends of improvement over time. Repeated measures ANOVA confirmed significant between-group differences in these outcomes, while the progression of improvement was identical in both groups. CONCLUSION: This study provides preliminary evidence that Pedilact probiotic drops may serve as a safe and natural complementary therapy for reducing colic symptoms compared to sucrose alone. However, larger blinded trials are needed to validate these findings and address limitations such as reliance on parental reporting. TRIAL REGISTRATION: This study was IRCT registration number: IRCT20230625058574N1 (Registration date: 2023-07-27). CI - (c) 2026. The Author(s). FAU - Zaker Tavallaie, Fateme AU - Zaker Tavallaie F AUID- ORCID: 0000-0003-3375-0863 AD - Department of Pediatrics, School of Medicine Heshmatie Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran. FAU - Aldaghi, Mitra Azra AU - Aldaghi MA AD - Department of Gastroenterology Pediatrics, Sabzevar University of Medical Sciences, Sabzevar, Iran. FAU - Rasti Sani, Seyedmorteza AU - Rasti Sani S AD - Department of Pediatrics, School of Medicine Heshmatie Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran. FAU - Amiri, Parastoo AU - Amiri P AUID- ORCID: 0000-0002-3085-8652 AD - Clinical Research Development Unit, Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran. FAU - Hassanpour, Kazem AU - Hassanpour K AUID- ORCID: 0000-0001-6281-2571 AD - Department of Gastroenterology Pediatrics, Sabzevar University of Medical Sciences, Sabzevar, Iran. drhassanpour@yahoo.com. FAU - Raeesi, Neda AU - Raeesi N AD - Department of Gastroenterology Pediatrics, Sabzevar University of Medical Sciences, Sabzevar, Iran. LA - eng GR - 401204/Sabzevar University of Medical Sciences/ PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20260707 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 57-50-1 (Sucrose) SB - IM MH - Humans MH - *Colic/therapy/drug therapy MH - *Probiotics/therapeutic use MH - Infant MH - *Sucrose/therapeutic use/administration & dosage MH - Crying MH - Female MH - Male MH - Treatment Outcome MH - Sleep Duration MH - Breast Feeding PMC - PMC13700407 OTO - NOTNLM OT - Crying time OT - Infantile colic; Probiotics OT - Sleep duration OT - Sucrose COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki and its later amendments. This study was approved by the research council and Ethics Committee of Sabzevar University of Medical Sciences, Sabzevar, Iran. Written informed consents were obtained from all study participants' parents or other legal guardians. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/08 02:07 MHDA- 2026/10/26 05:30 PMCR- 2026/07/07 CRDT- 2026/07/07 23:46 PHST- 2025/05/27 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/10/26 05:30 [medline] PHST- 2026/07/08 02:07 [pubmed] PHST- 2026/07/07 23:46 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - 10.1186/s12887-026-07271-x [pii] AID - 7271 [pii] AID - 10.1186/s12887-026-07271-x [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 7;26(1):1057. doi: 10.1186/s12887-026-07271-x. PMID- 42414418 OWN - NLM STAT- Publisher LR - 20260707 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 7 TI - Motor and cognitive development is associated with anthropometry and severe zinc deficiency in infants, in rural Madagascar. LID - 10.1038/s41598-026-59463-1 [doi] AB - Globally, more than 250 million children under five fail to reach their developmental potential, with malnutrition representing a major contributing factor. In Madagascar, as in many low- and middle-income countries, malnutrition remains a serious public health concern. Although the high prevalence of micronutrient deficiencies, stunting, and wasting is well documented, their consequences for early motor and cognitive development, which can be assessed reliably by six months, are less studied. In 2019, a baseline data collection prior to intervention as part of a randomized controlled trial conducted in the Amparafaravola district assessed 706 children aged 6-7 months. The findings revealed high prevalence of stunting (28.6%), wasting (3.3%), anemia (39.2%), and micronutrient deficiencies (48.7% for thiamine deficiency and 6.2% for severe zinc deficiency for example). Cognitive scores, assessed with the Mullen Scales of Early Learning, were comparable to other vulnerable populations. At six months, cognitive scores were strongly associated with stunting, wasting and severe zinc deficiency (p < 0.01). Associations with other micronutrient indicators, including anemia, low ferritin and vitamin A deficiency, were weaker and not statistically significant. Addressing these challenges requires multisectoral and well-targeted interventions. Therefore, further research is needed to improve our understanding of the longitudinal relationships between nutritional status, health and environmental factors, and cognitive and motor development. CI - (c) 2026. The Author(s). FAU - Fortin, Sonia AU - Fortin S AD - Institut de Recherche Pour le Developpement (IRD), Montpellier, France. sonia.fortin@ird.fr. AD - UMR QualiSud Universite de Montpellier, CIRAD, IRD, SupAgro, Avignon Universite, Universite de la Reunion, Montpellier, France. sonia.fortin@ird.fr. AD - IRD, UMR QualiSud, 911 avenue Agropolis, 34394, Montpellier Cedex, France. sonia.fortin@ird.fr. FAU - Razafindratsima, Yannick AU - Razafindratsima Y AD - GRET Madagascar, Antananarivo, Madagascar. FAU - Razakandrainy, Andry AU - Razakandrainy A AD - GRET Madagascar, Antananarivo, Madagascar. FAU - Randremanana, Rindra AU - Randremanana R AD - Epidemiology and Clinical Research Unit, Institut Pasteur Madagascar, Antananarivo, Madagascar. FAU - Ralison, Charlotte AU - Ralison C AD - Department of Food and Nutrition Science, University of Antananarivo, Antananarivo, Madagascar. FAU - Baldwin, Dare AU - Baldwin D AD - Psychology and Clark Honors College, University of Oregon, Eugene, USA. FAU - Measelle, Jeffrey AU - Measelle J AD - Global Health Program, University of Oregon, Eugene, USA. FAU - Mouquet-Rivier, Claire AU - Mouquet-Rivier C AD - Institut de Recherche Pour le Developpement (IRD), Montpellier, France. AD - UMR QualiSud Universite de Montpellier, CIRAD, IRD, SupAgro, Avignon Universite, Universite de la Reunion, Montpellier, France. FAU - Wieringa, Frank T AU - Wieringa FT AD - Institut de Recherche Pour le Developpement (IRD), Montpellier, France. AD - UMR QualiSud Universite de Montpellier, CIRAD, IRD, SupAgro, Avignon Universite, Universite de la Reunion, Montpellier, France. LA - eng GR - Food/2016/380-032/EuropeAid/151093/DH/ACT/Multi/ GR - Food/2016/380-032/EuropeAid/151093/DH/ACT/Multi/ GR - Food/2016/380-032/EuropeAid/151093/DH/ACT/Multi/ GR - Food/2016/380-032/EuropeAid/151093/DH/ACT/Multi/ GR - Food/2016/380-032/EuropeAid/151093/DH/ACT/Multi/ GR - Food/2016/380-032/EuropeAid/151093/DH/ACT/Multi/ GR - Food/2016/380-032/EuropeAid/151093/DH/ACT/Multi/ GR - Food/2016/380-032/EuropeAid/151093/DH/ACT/Multi/ GR - Food/2016/380-032/EuropeAid/151093/DH/ACT/Multi/ PT - Journal Article DEP - 20260707 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/08 02:08 MHDA- 2026/07/08 02:08 CRDT- 2026/07/07 23:26 PHST- 2026/03/11 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/08 02:08 [medline] PHST- 2026/07/08 02:08 [pubmed] PHST- 2026/07/07 23:26 [entrez] AID - 10.1038/s41598-026-59463-1 [pii] AID - 10.1038/s41598-026-59463-1 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 7. doi: 10.1038/s41598-026-59463-1. PMID- 42413912 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260925 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 23 IP - 10 DP - 2026 Oct 1 TI - Are Active Schools Associated With Active Commuting? Examining the Prevalence and Determinants in Young People. PG - 1444-1452 LID - 10.1123/jpah.2025-0724 [doi] AB - BACKGROUND: This study aimed to determine the prevalence of active commuting to school among children and adolescents in the Valencian Community (Spain) and to examine potential differences according to sociodemographic, institutional, and behavioral variables. METHODS: A total of 2232 students (8-18 y; 52.2% girls) from 20 schools participated. Sociodemographic (gender, educational stage, socioeconomic status), environmental (type of school: Active vs Non-Active), and behavioral (physical activity levels) variables were assessed using validated self-report instruments. Descriptive and bivariate analyses were conducted using Rao-Scott-adjusted chi-square tests for complex samples, and associations between commuting modes and study variables were subsequently examined using cluster-adjusted generalized estimating equations. RESULTS: Overall, 69% of students actively commuted to and from school. Significant differences were observed by gender and socioeconomic status, whereas no differences were found by educational stage, school type, or physical activity level. When commuting modes were examined, walking was the predominant behavior while cycling was rare (1.3%). Boys and students from lower-income households were more likely to walk, and boys were also more likely than girls to cycle. CONCLUSIONS: The study reveals that most students engage in active commuting to school, mainly by walking, although significant disparities persist according to sociodemographic variables. These findings highlight the need for future research to explore the specific barriers and facilitators of active commuting to school in young people, particularly among girls. They also support the implementation and systematic evaluation of school-based strategies designed to reduce these disparities and promote active, healthy, and sustainable mobility within the school. FAU - Sanchis-Frances, Lucia AU - Sanchis-Frances L AUID- ORCID: 0009-0008-9197-480X AD - Universitat de Valencia, Valencia, Spain. FAU - Valencia-Peris, Alexandra AU - Valencia-Peris A AUID- ORCID: 0000-0002-2031-9743 AD - Universitat de Valencia, Valencia, Spain. FAU - Ferriz, Roberto AU - Ferriz R AUID- ORCID: 0000-0001-7041-4098 AD - Universitat de Valencia, Valencia, Spain. FAU - Lizandra, Jorge AU - Lizandra J AUID- ORCID: 0000-0001-5599-133X AD - Universitat de Valencia, Valencia, Spain. LA - eng PT - Journal Article DEP - 20260707 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Transportation/methods/statistics & numerical data MH - Male MH - Child MH - *Bicycling/statistics & numerical data MH - Walking/statistics & numerical data MH - *Schools/statistics & numerical data MH - Spain MH - Socioeconomic Factors MH - Students/statistics & numerical data MH - *Exercise MH - Sex Factors MH - Sociodemographic Factors OTO - NOTNLM OT - active transport OT - physical activity OT - program evaluation OT - youth EDAT- 2026/07/08 01:48 MHDA- 2026/09/25 17:32 CRDT- 2026/07/07 19:33 PHST- 2025/09/25 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/02 00:00 [accepted] PHST- 2026/09/25 17:32 [medline] PHST- 2026/07/08 01:48 [pubmed] PHST- 2026/07/07 19:33 [entrez] AID - 10.1123/jpah.2025-0724 [doi] PST - epublish SO - J Phys Act Health. 2026 Jul 7;23(10):1444-1452. doi: 10.1123/jpah.2025-0724. Print 2026 Oct 1. PMID- 42413906 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260729 IS - 1543-2920 (Electronic) IS - 0899-8493 (Linking) VI - 38 IP - 3 DP - 2026 Aug 1 TI - Finding the Goldilocks Zone for Toddler Accelerometry: How Many Days Are Needed for a Reliable Estimate of Physical Activity and Sedentary Time Using Machine Learning? PG - 293-298 LID - 10.1123/pes.2025-0147 [doi] AB - PURPOSE: To understand how many days and hours per day of accelerometer wear are needed for a reliable estimation of sedentary time and physical activity (PA) using machine learning (ML). METHOD: One hundred and nine toddlers wore an accelerometer on the right hip at home for 7 days. Time in sedentary time, light PA, moderate to vigorous PA, and total PA were assessed using a validated ML model for toddlers. Single-day intraclass coefficients were calculated for each minimum hours per day of wear time and each outcome. These intraclass coefficients were passed to the Spearman-Brown prophecy equation to determine the reliability of each hour per day and days combination (3-12 h, 1-10 d). RESULTS: Predicted reliabilities ranged from 0.32 to 0.98, increasing as both numbers of hours per day and number of days increased. Four days of 6 hours of wear balances a 0.7 reliability threshold while retaining 94% of participants. CONCLUSION: Our findings support the recommended 6 hours per day of wear for at least 4 days, as it balances acceptable reliability with participant retention. This recommendation is valid for this ML method, and we anticipate that it can be used to further explore sedentary time and PA in toddlers using ML advances. FAU - Letts, Elyse AU - Letts E AUID- ORCID: 0000-0002-2543-8346 AD - Department of Pediatrics, Child Health & Exercise Medicine Program, McMaster University,Hamilton, ON,Canada. FAU - da Silva, Sarah M AU - da Silva SM AUID- ORCID: 0009-0001-9512-9776 AD - Department of Pediatrics, Child Health & Exercise Medicine Program, McMaster University,Hamilton, ON,Canada. FAU - King-Dowling, Sara AU - King-Dowling S AUID- ORCID: 0000-0003-3670-8425 AD - Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA,USA. FAU - Di Cristofaro, Natascja AU - Di Cristofaro N AD - Department of Pediatrics, Child Health & Exercise Medicine Program, McMaster University,Hamilton, ON,Canada. FAU - Obeid, Joyce AU - Obeid J AUID- ORCID: 0000-0002-6209-1505 AD - Department of Pediatrics, Child Health & Exercise Medicine Program, McMaster University,Hamilton, ON,Canada. AD - Department of Kinesiology, McMaster University,Hamilton, ON,Canada. LA - eng PT - Journal Article DEP - 20260707 PL - United States TA - Pediatr Exerc Sci JT - Pediatric exercise science JID - 8909729 SB - IM MH - Humans MH - *Accelerometry/methods MH - *Sedentary Behavior MH - Reproducibility of Results MH - *Machine Learning MH - Male MH - Female MH - *Exercise MH - Time Factors MH - Child, Preschool OTO - NOTNLM OT - actigraphy OT - early years OT - reliability EDAT- 2026/07/08 01:49 MHDA- 2026/07/29 13:54 CRDT- 2026/07/07 19:32 PHST- 2025/11/05 00:00 [received] PHST- 2026/02/04 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/07/29 13:54 [medline] PHST- 2026/07/08 01:49 [pubmed] PHST- 2026/07/07 19:32 [entrez] AID - 10.1123/pes.2025-0147 [doi] PST - epublish SO - Pediatr Exerc Sci. 2026 Jul 7;38(3):293-298. doi: 10.1123/pes.2025-0147. Print 2026 Aug 1. PMID- 42413822 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260902 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Integrating executive function training with health behavior intervention for preschool obesity prevention in China: a cluster-randomized controlled trial. PG - 101427 LID - S0002-9165(26)00236-4 [pii] LID - 10.1016/j.ajcnut.2026.101427 [doi] AB - BACKGROUND: Preschool is a critical period for obesity prevention. However, few real-world interventions have integrated executive function (EF) enhancing activities with health behavior promotion. OBJECTIVES: To evaluated the effectiveness of a multilevel kindergarten-family intervention among preschoolers in China. METHODS: In this cluster-randomized controlled trial, 26 kindergartens in Wuhan were stratified by kindergarten educational tier and randomly assigned (1:1) to either the intervention or control group. The intervention comprised health education, EF-enhancing activities, environmental modifications, and family engagement strategies over 3 semesters. The primary outcome was change in body mass index z-score (BMIz); secondary outcomes included EF performance and health behaviors. Linear mixed models accounted for clustering and repeated measures; a bias-reduced linearization (CR2) cluster-robust small-sample-corrected sensitivity analysis was conducted. RESULTS: Of 1239 children included, 638 were assigned to the intervention group and 601 to the control group; 21.2% were classified as having overweight or obesity at baseline. In the primary analysis, BMIz gain was smaller in the interventions than in controls [mean difference (MD), -0.08; P = 0.043]. EF performance improved at midline in Digit Span Test 1 (MD: 0.28; P = 0.002), Digit Span Test 2 (MD: 0.23; P = 0.15), and Corsi Block Tapping Test 2 (MD: 0.41; P < 0.001). At the endpoint, the simplified Stroop day-night task showed a nominal improvement (MD: 0.48; P = 0.009). The healthy dietary consumption scores changed favorably (MD: -0.73; P = 0.017). Exploratory subgroup analyses suggested possible heterogeneity by kindergarten tier at midline (P for interaction = 0.086) and by sex at endpoint (P for interaction = 0.052), with a larger estimated endline effect among boys. CONCLUSIONS: This kindergarten-family intervention showed directionally favorable but statistically uncertain effects on BMIz gain after small-sample correction, alongside modest improvements in selected EF outcomes. These findings support the feasibility and potential promise of this approach for early obesity prevention, whereas larger trials are needed to confirm effectiveness, durability, and equity across settings. The trial was registered at the Chinese Clinical Trial Registry as ChiCTR2200058452 (9 April, 2022; https://www.chictr.org.cn/hvshowproject.html?id=205233&v=1.1). CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Wang, Miyuan AU - Wang M AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Xia, Wenqi AU - Xia W AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Xu, Ke AU - Xu K AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Evidence-based Nursing Center, West China Hospital, Sichuan University, Chengdu, China. FAU - Chen, Fengyan AU - Chen F AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wang, Yimin AU - Wang Y AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wei, Mengna AU - Wei M AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Deng, Weixi AU - Deng W AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zheng, Xinyi AU - Zheng X AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zhang, Zengzhen AU - Zhang Z AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Xiong, Jinrui AU - Xiong J AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wang, Lingyu AU - Wang L AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Lin, Yuxin AU - Lin Y AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wang, Youfa AU - Wang Y AD - Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an City, China. FAU - Zhang, Jianduan AU - Zhang J AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: jd_zh@hust.edu.cn. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260707 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - *Executive Function MH - Child, Preschool MH - Male MH - China MH - *Pediatric Obesity/prevention & control MH - Female MH - *Health Behavior MH - Body Mass Index MH - *Health Promotion OTO - NOTNLM OT - childhood obesity OT - cluster-randomized control trial OT - energy balance-related behavior OT - executive function OT - preschool intervention COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/08 01:43 MHDA- 2026/09/01 23:34 CRDT- 2026/07/07 19:14 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/28 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/08 01:43 [pubmed] PHST- 2026/07/07 19:14 [entrez] AID - S0002-9165(26)00236-4 [pii] AID - 10.1016/j.ajcnut.2026.101427 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101427. doi: 10.1016/j.ajcnut.2026.101427. Epub 2026 Jul 7. PMID- 42412896 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Longitudinal associations of academic stress with eating related patterns, nutrition, somatic indicators, and depressive symptoms in university students: A study protocol. PG - e0352779 LID - 10.1371/journal.pone.0352779 [doi] LID - e0352779 AB - INTRODUCTION: Academic stress (AS) can be understood as a multidimensional form of chronic stress that has been linked to adverse patterns across physical and mental health in university students. This protocol outlines a longitudinal, observational study to examine within-semester associations between AS and indicators of nutritional status, eating-related patterns, sleep quality, and depressive symptoms. By integrating physiological, behavioral, and psychological indicators within a repeated-measures framework, the study aims to generate evidence that can inform prevention-focused actions and early support strategies in university health contexts. HYPOTHESES: (i) Higher AS will be longitudinally associated with less favorable eating-related patterns, nutritional and somatic indicators, and higher depressive symptoms in university students. (ii) Higher AS will be associated with altered post-awakening cortisol dynamics, specifically a lower cortisol awakening response (CAR) and lower AUCi, together with a higher AUCg, and with higher salivary alpha-amylase (sAA) levels, consistent with stress-related activation of HPA-axis and sympathetic pathways. DESIGN AND PARTICIPANTS: A longitudinal, observational, nonexperimental design with repeated measurements will be implemented across three assessment cycles during an academic semester. A feasibility-based convenience sample will be recruited from undergraduate students (2nd to 4th year) enrolled in the Faculty of Medicine, University of Concepcion (Chile). Students receiving psychological or pharmacological treatment will be eligible to reflect real-world heterogeneity and support ecological validity. METHODS: Data will be collected through standardized questionnaires, nutritional assessments, biological sampling, and wearable-derived somatic indicators. Electronic surveys administered via REDCap will assess AS, perceived stress, eating-related patterns, and depressive symptoms. Diet will be assessed through interviewer-administered nutritional interviews, including repeated 24-hour dietary recalls treated as time-specific observations and modeled longitudinally as time-varying measures, and complemented by diet-quality and dietary inflammatory potential indices. Wearable devices will record nonclinical somatic indicators, including heart rate, oxygen saturation, and sleep-related metrics during monitoring periods. Saliva will be collected twice per week during each assessment cycle to quantify salivary cortisol dynamics and sAA activity, and peripheral blood samples obtained at baseline and end of semester will be used to determine lipid profile, fasting glucose, albumin, globulin, and total proteins. STATISTICAL ANALYSIS: Analyses will include descriptive and bivariate summaries, followed by multivariable models appropriate to outcome type. Longitudinal associations will be examined using mixed-effects models, and temporal cross-lagged associations will be explored using random-intercept cross-lagged panel models across the three assessment cycles. All inferences will be framed as associational given the observational design. EXPECTED RESULTS: Rather than prespecifying outcomes, this protocol is expected to generate longitudinal evidence on how within-semester variation in AS aligns with eating-related patterns, diet, nutritional and somatic indicators, depressive symptoms, and stress-related physiological indicators (salivary cortisol dynamics and sAA activity). The integrated, feasibility-oriented measurement framework may serve as a replicable template for future research and inform prevention-focused actions to support student well-being in university settings. CI - Copyright: (c) 2026 Rojas-Cardenas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Rojas-Cardenas, Pia AU - Rojas-Cardenas P AUID- ORCID: 0000-0002-6208-0830 AD - Programa de Doctorado en Salud Mental, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad Adventista de Chile, Nuble, Chile. FAU - Nazar, Gabriela AU - Nazar G AD - Departamento de Psicologia, Facultad de Ciencias Sociales, Universidad de Concepcion, Concepcion, Chile. FAU - Castillo-Navarrete, Juan Luis AU - Castillo-Navarrete JL AUID- ORCID: 0000-0002-7401-2384 AD - Programa de Doctorado en Salud Mental, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. AD - Departamento de Tecnologia Medica, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. AD - Programa de Neurociencia, Psiquiatria y Salud Mental, NEPSAM, Universidad de Concepcion, Concepcion, Chile. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260707 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - Cortisol Awakening Response MH - *Depression/psychology/physiopathology MH - *Feeding Behavior/psychology MH - Hydrocortisone/metabolism MH - Longitudinal Studies MH - *Nutritional Status MH - Saliva/metabolism MH - Sleep Quality MH - *Stress, Psychological/psychology/physiopathology/metabolism MH - *Students/psychology MH - Universities MH - Observational Studies as Topic PMC - PMC13340845 COIS- The authors declare no competing interests. Funding was provided by Agencia Nacional de Investigacion y Desarrollo (ANID), Chile: FONDECYT Iniciacion No. 11240383 (recipient: Juan Luis Castillo-Navarrete) and ANID Doctoral Scholarship No. 1340/2025 (recipient: Pia Rojas-Cardenas). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. EDAT- 2026/07/08 01:10 MHDA- 2026/07/08 01:11 PMCR- 2026/07/07 CRDT- 2026/07/07 13:43 PHST- 2025/12/18 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/08 01:11 [medline] PHST- 2026/07/08 01:10 [pubmed] PHST- 2026/07/07 13:43 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - PONE-D-25-67135 [pii] AID - 10.1371/journal.pone.0352779 [doi] PST - epublish SO - PLoS One. 2026 Jul 7;21(7):e0352779. doi: 10.1371/journal.pone.0352779. eCollection 2026. PMID- 42412396 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1440-172X (Electronic) IS - 1322-7114 (Print) IS - 1322-7114 (Linking) VI - 32 IP - 4 DP - 2026 Aug TI - Validity of the Translated Turkish Version of the Tool for Nutrition Risk Screening for Paediatric Cancer. PG - e70168 LID - 10.1111/ijn.70168 [doi] LID - e70168 AB - BACKGROUND: Malnutrition in paediatric cancer patients increases adverse clinical outcomes; however, methods for assessing malnutrition risk remain unclear. This study aimed to assess the validity of the Nutrition Risk Screening for Pediatric Cancer (NRS-PC). METHODS: This cross-sectional study was conducted in the paediatric oncology unit of a tertiary care university hospital. The nutritional risk and malnutrition status were assessed by the Nutrition Screening Tool for Childhood Cancer (SCAN) and Pediatric Subjective Global Nutritional Assessment (SGNA), respectively. Receiver-operator characteristic (ROC) curve method was used to evaluate the validity of NRS-PC. Sensitivity, specificity, positive and negative predictive values were calculated. RESULTS: The median age of children was 8 years, and 60.2% were boys. The prevalence of malnutrition was 48.4%. NRS-PC had excellent accuracy compared with SCAN (AUC: 0.87, 95% CI: 0.827-0.944; p < 0.001) and SGNA (AUC: 0.90, 95% CI: 0.847-0.951; p < 0.001). Using SGNA as a reference method, the NRS-PC tool had a sensitivity of 77.4%-100% and specificity of 24.2%-86.4% according to different cut-off points. CONCLUSION: The Turkish version of the NRS-PC is a simple, valid and practical method for nutritional risk screening in the paediatric oncology population. Further feasibility and acceptability studies are needed to determine the most appropriate screening tools in children. CI - (c) 2026 The Author(s). International Journal of Nursing Practice published by John Wiley & Sons Australia, Ltd. FAU - Meral, Buket AU - Meral B AUID- ORCID: 0000-0003-1664-9333 AD - Department of Child Health and Diseases Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey. FAU - Kangalgil, Melda AU - Kangalgil M AUID- ORCID: 0000-0003-2868-8903 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, Turkey. FAU - Erduran, Erol AU - Erduran E AD - Department of Pediatric Hematology and Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. LA - eng PT - Journal Article PT - Validation Study PL - Australia TA - Int J Nurs Pract JT - International journal of nursing practice JID - 9613615 SB - IM MH - Humans MH - Turkey MH - Male MH - Child MH - Cross-Sectional Studies MH - Female MH - *Nutrition Assessment MH - *Neoplasms/complications MH - *Malnutrition/diagnosis MH - Child, Preschool MH - Risk Assessment MH - Nutritional Status PMC - PMC13340497 OTO - NOTNLM OT - malnutrition OT - nurses OT - nursing OT - nutritional assessment OT - paediatric oncology OT - sensitivity OT - specificity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/07 12:34 MHDA- 2026/07/07 18:54 PMCR- 2026/07/07 CRDT- 2026/07/07 11:26 PHST- 2026/06/01 00:00 [revised] PHST- 2025/03/11 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/07 18:54 [medline] PHST- 2026/07/07 12:34 [pubmed] PHST- 2026/07/07 11:26 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - IJN70168 [pii] AID - 10.1111/ijn.70168 [doi] PST - ppublish SO - Int J Nurs Pract. 2026 Aug;32(4):e70168. doi: 10.1111/ijn.70168. PMID- 42410484 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261002 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Jul 6 TI - Misreporting of energy intake estimated by food records among adolescents in Lao People's Democratic Republic: a cross-sectional study. LID - 10.1186/s40795-026-01416-y [doi] LID - 203 AB - BACKGROUND: Accurate dietary assessment data is vital for understanding dietary patterns and the associated nutrition and health outcomes. However, research on misreporting from self-reported dietary assessment tools has remained limited in low- and middle-income countries. Our study aims to investigate energy intake misreporting and its determinants among adolescents in Lao People's Democratic Republic (PDR). METHODS: We conducted a cross-sectional secondary analysis of seven-day estimated food records collected from 405 adolescents aged 10-18 years attending secondary schools in Vientiane Province, Lao PDR, between March and April 2019. We identified energy intake misreporting using the Goldberg cut-off method, and analyzed factors associated with energy intake underreporting using multivariable logistic regression analyses. We compared the percentage energy intake from each food group between plausible reporters and underreporters, using the Mann-Whitney U-test. RESULTS: Approximately 61.2% of participants underreported and 0.3% overreported their energy intake. Older adolescents (15-18 years) were 50% less likely to be classified as underreporters than younger adolescents (10-14 years) (Adjusted Odds Ratio [AOR] = 0.54, 95% CI: 0.34-0.88). Higher Body Mass Index was associated with higher odds of underreporting (AOR = 1.09, 95% CI: 1.01-1.18), whereas higher number of reported snacks between meals was associated with lower odds of underreporting (AOR = 0.81, 95% CI: 0.76-0.86). Underreporting increased over the seven-day period (51.4% on day 1 to 65.9% on day 7). CONCLUSIONS: This study highlights a high prevalence of energy intake underreporting among Lao PDR adolescents when using the seven-day estimated food record method. While this prospective method has advantages, its accuracy depends on sustained participant engagement and motivation. Future research is needed to develop, adapt and validate tools, such as technology-assisted tools, for use among adolescents in Lao PDR. CI - (c) 2026. The Author(s). FAU - Kounnavong, Thidatheb AU - Kounnavong T AUID- ORCID: 0009-0007-5614-6147 AD - School of Tropical Medicine and Global Health, Nagasaki University, 1 Chome-12-4 Sakamoto, Nagasaki, 852-8102, Japan. thidatheb.kounnavong@nagasaki-u.ac.jp. FAU - Moji, Kazuhiko AU - Moji K AD - School of Tropical Medicine and Global Health, Nagasaki University, 1 Chome-12-4 Sakamoto, Nagasaki, 852-8102, Japan. moji.k273@gmail.com. FAU - Sato, Miho AU - Sato M AD - School of Tropical Medicine and Global Health, Nagasaki University, 1 Chome-12-4 Sakamoto, Nagasaki, 852-8102, Japan. FAU - Turner, Christopher AU - Turner C AD - Food and Markets Department, Natural Resources Institute, University of Greenwich, London, UK. FAU - Vonglokham, Manithong AU - Vonglokham M AD - Department of Health Policy and Health System Research, Lao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic. FAU - Ferguson, Elaine AU - Ferguson E AD - Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK. LA - eng PT - Journal Article DEP - 20260706 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13625445 OTO - NOTNLM OT - Adolescent OT - Cross sectional study OT - Dietary assessment OT - Energy intake OT - Food Record OT - Lao People's Democratic Republic OT - Misreporting OT - Technologies OT - Underreporting COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. The study utilized secondary data collected as part of a separate project conducted by the Lao Tropical and Public Health Institute, which received ethical approval from the National Ethical Committee for Health Research of Lao PDR (Protocol No. 013/2019/NECHR). Informed consent was obtained from all adolescent participants and their legal guardians before the data were collected. The study strictly followed the relevant guidelines and regulations. The dataset is fully anonymized and de-identified, ensuring that no individual participants could be identified or traced. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/07 00:38 MHDA- 2026/07/07 00:39 PMCR- 2026/07/06 CRDT- 2026/07/07 00:00 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/07/07 00:39 [medline] PHST- 2026/07/07 00:38 [pubmed] PHST- 2026/07/07 00:00 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - 10.1186/s40795-026-01416-y [pii] AID - 1416 [pii] AID - 10.1186/s40795-026-01416-y [doi] PST - epublish SO - BMC Nutr. 2026 Jul 6;12(1):203. doi: 10.1186/s40795-026-01416-y. PMID- 42409932 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20261001 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jul 6 TI - Normalization of muscle strength measures in barbell exercises by sex, age, and anthropometry: notes on allometry. LID - 10.1038/s41598-026-60646-z [doi] LID - 20797 AB - Accurate strength assessment requires consideration of individual anthropometric and demographic differences. Traditional absolute and body mass-normalized measures often fail to capture inter-individual variability, thereby limiting the precision of strength testing and classification. This study aimed to investigate the influence of age, body mass, height, and anthropometric characteristics on strength capacity and to systematically integrate these variables into a classification framework. A total of 393 individuals (197 females, 196 males), aged 16-64 years and ranging from beginners to elite powerlifters, were recruited. One-repetition maximum (1-RM) strength was assessed in the bench press (BP), back squat (SQ), and deadlift (DL). Age, height, body mass, and selected anthropometric variables including arm and leg lengths, were recorded. Multiple regression analyses were used to quantify the influence of these variables on 1-RM performance. Based on significant predictors, individualized z-scores were computed to standardize 1-RM values relative to relevant anthropometric and demographic factors. The applicability of these z-scores to interval-based classification frameworks was evaluated. Age, body mass, and height were identified as significant determinants of maximal strength across all 3 exercises. Incorporation of these variables into z-score calculation enabled a more precise and individualized assessment of strength performance. Attempts to apply z-scores to interval-based classification frameworks revealed substantial within-category heterogeneity, indicating that such frameworks are unsuitable for accurate strength classification. This study establishes an anthropometry- and demography-adjusted framework for strength assessment in BP, SQ, and DL among healthy adults aged 16-64 years. Standardized z-scores provide a biologically meaningful alternative to conventional normalization methods. The proposed z-score framework provides a reproducible, data-driven tool for individualized strength assessment in the BP, SQ and DL, with direct applications in sport science research, performance monitoring, and strength-based rehabilitation for healthy adults aged 16-64 years. CI - (c) 2026. The Author(s). FAU - Isenmann, Eduard AU - Isenmann E AUID- ORCID: 0000-0003-3300-5118 AD - Department of Fitness and Health, IST University of Applied Sciences, Duesseldorf, Germany. eisenmann@ist-hochschule.de. AD - Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany. eisenmann@ist-hochschule.de. FAU - Geisler, Stephan AU - Geisler S AD - Department of Fitness and Health, IST University of Applied Sciences, Duesseldorf, Germany. FAU - Havers, Tim AU - Havers T AD - Department of Fitness and Health, IST University of Applied Sciences, Duesseldorf, Germany. AD - Exercise Biology Group, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Gavanda, Simon AU - Gavanda S AD - Department of Fitness and Health, IST University of Applied Sciences, Duesseldorf, Germany. FAU - Diel, Patrick AU - Diel P AD - Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany. FAU - Held, Steffen AU - Held S AD - Department of Sport and Management, IST University of Applied Sciences, Duesseldorf, Germany. FAU - Flenker, Ulrich AU - Flenker U AD - Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260706 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Female MH - Adult MH - *Muscle Strength/physiology MH - Humans MH - Adolescent MH - Middle Aged MH - Male MH - Young Adult MH - *Anthropometry MH - Age Factors MH - *Weight Lifting/physiology MH - Sex Factors MH - *Exercise/physiology PMC - PMC13338387 OTO - NOTNLM OT - Allometric scaling OT - Framework OT - Maximal strength OT - Performance OT - Strength classification COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/07 00:39 MHDA- 2026/07/07 19:11 PMCR- 2026/07/06 CRDT- 2026/07/06 23:27 PHST- 2026/02/10 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/07/07 19:11 [medline] PHST- 2026/07/07 00:39 [pubmed] PHST- 2026/07/06 23:27 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - 10.1038/s41598-026-60646-z [pii] AID - 60646 [pii] AID - 10.1038/s41598-026-60646-z [doi] PST - epublish SO - Sci Rep. 2026 Jul 6;16(1):20797. doi: 10.1038/s41598-026-60646-z. PMID- 42409604 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1369-1600 (Electronic) IS - 1355-6215 (Print) IS - 1355-6215 (Linking) VI - 31 IP - 7 DP - 2026 Jul TI - Effects of Different Exercise Intensities on Internet Addiction in Adolescents and Young Adults: A Systematic Review and Network Meta-Analysis. PG - e70172 LID - 10.1111/adb.70172 [doi] LID - e70172 AB - This study employed a network meta-analysis to evaluate and compare the efficacy of different exercise intensities (light, moderate and vigorous) on internet addiction and related psychological symptoms in adolescents and young adults. We systematically searched eight databases for relevant randomised controlled trials. A total of 22 studies with 1438 samples were included. A pairwise meta-analysis indicated that exercise interventions across all intensities were associated with improvements in internet addiction, anxiety and negative moods, with moderate-intensity additionally improving depression. The results of the network meta-analysis suggested that light-intensity exercise (SMD = -2.61, 95% CI [-4.29, -0.93], p = 0.002), moderate-intensity exercise (SMD = -2.74, 95% CI [-4.25, -1.22], p < 0.0001) and high-intensity exercise (SMD = -2.55, 95% CI [-4.88, -0.22], p = 0.032) may be associated with a reduction in adolescents' internet addiction. Only moderate-intensity exercise may be associated with a reduction in depression (SMD = -1.19, 95% CI [-2.20, -0.18], p = 0.021) and anxiety (SMD = -1.90, 95% CI [-3.50, -0.30], p = 0.02); light-intensity and high-intensity exercise were not significantly associated with a reduction in depression and anxiety. Light-intensity exercise (SMD = -1.63, 95% CI [-2.85, -0.41], p = 0.009) and moderate-intensity exercise (SMD = -1.55, 95% CI [-2.56, -0.54], p = 0.003) may be associated with reductions in other negative moods. According to the probability ranking of the likelihood of the optimal intervention effect, moderate-intensity exercise (SUCRA = 71) ranked highest for interventions in adolescents' internet addiction, depression (SUCRA = 70.2), anxiety (SUCRA = 68.4) and light exercise (SUCRA = 67.9) ranked highest for negative moods. However, owing to the limitations of sample size and the quality of individual studies, the strength of evidence needs to be further validated by more standardised, high-quality studies. CI - (c) 2026 The Author(s). Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. FAU - Yu, Min AU - Yu M AD - School of Physical Education, Hunan University of Arts and Science, Changde, China. FAU - Chang, Yuanyuan AU - Chang Y AD - School of Physical Education and Health Engineering, Taiyuan University of Technology, Taiyuan, China. FAU - Kang, Haobo AU - Kang H AD - School of Physical Education and Health Engineering, Taiyuan University of Technology, Taiyuan, China. FAU - Mao, Wuyang AU - Mao W AD - School of Physical Education, Hunan University, Changsha, China. LA - eng GR - 25JGYB0441/Hunan Provincial Basic Education Teaching Reform Research Project/ PT - Journal Article PT - Network Meta-Analysis PT - Systematic Review PL - United States TA - Addict Biol JT - Addiction biology JID - 9604935 SB - IM MH - Adolescent MH - Humans MH - Young Adult MH - Anxiety/therapy/psychology MH - *Behavior, Addictive/therapy MH - Depression/therapy/psychology MH - *Exercise/psychology MH - Exercise Therapy/methods MH - Internet MH - *Internet Addiction Disorder/therapy/psychology PMC - PMC13337322 OTO - NOTNLM OT - anxiety OT - depression OT - exercise intensity OT - internet addiction OT - negative moods COIS- The authors declare no conflicts of interest. EDAT- 2026/07/07 00:39 MHDA- 2026/07/07 18:53 PMCR- 2026/07/06 CRDT- 2026/07/06 21:23 PHST- 2026/05/08 00:00 [revised] PHST- 2025/12/12 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/07 18:53 [medline] PHST- 2026/07/07 00:39 [pubmed] PHST- 2026/07/06 21:23 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - ADB70172 [pii] AID - 10.1111/adb.70172 [doi] PST - ppublish SO - Addict Biol. 2026 Jul;31(7):e70172. doi: 10.1111/adb.70172. PMID- 42406088 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 1437-1596 (Electronic) IS - 0937-9827 (Print) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Diagnostic performance of Demirjian's third molar maturation stages G, G1, and H for identifying the 18-year age threshold: a sex-specific study. PG - 4435-4443 LID - 10.1007/s00414-026-03904-z [doi] AB - Determining attainment of 18 years is a critical task in forensic age estimation. This study evaluated and compared the sex-specific diagnostic performance of conventional and refined third-molar maturation cut-offs, Demirjian stages G and H, and the refined stage G1 for identifying individuals aged >/= 18 years in a South Indian population. Panoramic radiographs of 599 individuals aged 14-22 years were retrospectively assessed. Mandibular left third molars were staged using the conventional Demirjian system and the Solari and Abramovitch modification. Diagnostic performance was evaluated separately for males and females using sensitivity, specificity, predictive values, likelihood ratios, accuracy, and post-test probabilities. Intra- and inter-examiner agreement was assessed using kappa statistics. Third-molar maturation effectively discriminated attainment of 18 years in both sexes, with stage-dependent trade-offs between sensitivity and specificity. Stages G and above and stages G1 and above demonstrated high sensitivity and strong exclusion of adulthood when negative, whereas stage H showed higher specificity and greater confirmatory value when present, particularly among females. Diagnostic performance of the refined G1 stage was comparable to that of stage G, with modest improvement in specificity and post-test probability in females. Inter-examiner agreement was excellent for stages G and H but only moderate for G1, indicating reduced reproducibility for the refined stage. In conclusion, conventional Demirjian stages G and H remain reliable and reproducible indicators for assessing attainment of 18 years. Although the refined G1 stage offers increased developmental resolution and supports probabilistic interpretation, its forensic utility is constrained by reduced inter-observer agreement. CI - (c) 2026. The Author(s). FAU - Balla, Sudheer Babu AU - Balla SB AUID- ORCID: 0000-0003-0977-3889 AD - Department of Rural Clinical Sciences, La Trobe University, Bendigo, 3550, Australia. s.balla@latrobe.edu.au. FAU - Nagarakanti, Naga Madhuri AU - Nagarakanti NM AD - Government Medical College, Mahbubnagar, Telangana, India. FAU - Chinni, Subramanyeswara Swamy AU - Chinni SS AD - Clinical Practitioner, Chicago, USA. FAU - Shahnaz, Waheeda AU - Shahnaz W AD - SVS Institute of Dental Sciences, Mahabubnagar, Telangana, India. FAU - Bojji, Manasa AU - Bojji M AD - Malla Reddy Dental College for Women, Hyderabad., Telangana, India. FAU - Pacha, Venkat Baghirath AU - Pacha VB AD - Panineeya Institute of Dental Sciences & Research Center, Hyderabad, Telangana, India. LA - eng PT - Journal Article DEP - 20260706 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 RN - Indian people SB - IM MH - Retrospective Studies MH - *Molar, Third/diagnostic imaging/growth & development MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - *Age Determination by Teeth/methods MH - Radiography, Panoramic MH - South Asian People PMC - PMC13658497 OTO - NOTNLM OT - Age of majority OT - Demirjian method OT - Dental age estimation OT - Diagnostic accuracy OT - Refined root stages OT - Third molar COIS- Declarations. Ethical standards: Yes. Ethics approval: Obtained. Research involving human participants, their data, or biological material: Radiographs were collected retrospectively from the archives. Human ethics and consent to participate: Not applicable. Competing interest: The authors declare no competing interests. EDAT- 2026/07/06 12:41 MHDA- 2026/10/12 17:30 PMCR- 2026/07/06 CRDT- 2026/07/06 11:15 PHST- 2026/04/04 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/06 12:41 [pubmed] PHST- 2026/07/06 11:15 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - 10.1007/s00414-026-03904-z [pii] AID - 3904 [pii] AID - 10.1007/s00414-026-03904-z [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):4435-4443. doi: 10.1007/s00414-026-03904-z. Epub 2026 Jul 6. PMID- 42405474 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2051-817X (Electronic) IS - 2051-817X (Linking) VI - 14 IP - 13 DP - 2026 Jul TI - Free-living associations between resting heart rate parameters and cardiometabolic health in adults. PG - e71008 LID - 10.14814/phy2.71008 [doi] LID - e71008 AB - This study examined associations between multi-day ultra-short resting heart rate (HR) parameters and cardiometabolic health under free-living conditions. Sixty-seven adults (18-59 years, 53% male) completed seven consecutive days of seated 1-min RR interval recordings after waking using a validated chest strap monitor. Log-transformed root mean square of successive differences (LnRMSSD(M)) and resting HR (HR(M)) were averaged across days and standardized. Cardiometabolic health status was defined as the number of metabolic syndrome (MetS) components present. Associations were assessed using Poisson regression adjusted for age and sex, with additional models including HR(M) and HR-adjusted LnRMSSD. Higher LnRMSSD(M) was associated with fewer MetS components (IRR = 0.79, 95% CI: 0.64-0.97), whereas higher HR(M) was associated with greater metabolic burden (IRR = 1.40, 95% CI: 1.10-1.77). When both variables were included, the association between LnRMSSD(M) and MetS was attenuated and no longer significant (IRR = 0.93, 95% CI: 0.72-1.22), while HR(M) remained significant (IRR = 1.33, 95% CI: 1.00-1.77). Resting HR parameters obtained through accessible devices were associated with cardiometabolic health, with resting HR accounting for much of the cross-sectional information captured by LnRMSSD. Remote cardiac monitoring may support early cardiometabolic risk identification and longitudinal health surveillance. CI - (c) 2026 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. FAU - Gonzalez-Fimbres, Roberto A AU - Gonzalez-Fimbres RA AUID- ORCID: 0000-0003-2166-7085 AD - Licenciatura en Entrenamiento Deportivo, Unidad Academica Hermosillo, Universidad Estatal de Sonora, Hermosillo, Sonora, Mexico. FAU - Cuevas-Castro, Claudia S AU - Cuevas-Castro CS AD - Licenciatura en Entrenamiento Deportivo, Unidad Academica Hermosillo, Universidad Estatal de Sonora, Hermosillo, Sonora, Mexico. FAU - Ramirez-Siqueiros, Maria G AU - Ramirez-Siqueiros MG AD - Licenciatura en Entrenamiento Deportivo, Unidad Academica Hermosillo, Universidad Estatal de Sonora, Hermosillo, Sonora, Mexico. FAU - Valencia-Falcon, Teresita AU - Valencia-Falcon T AD - Licenciatura en Entrenamiento Deportivo, Unidad Academica Hermosillo, Universidad Estatal de Sonora, Hermosillo, Sonora, Mexico. FAU - Flatt, Andrew AU - Flatt A AD - Health Sciences and Kinesiology, Biodynamics and Human Performance Center, Georgia Southern University, Savannah, Georgia, USA. LA - eng GR - UES-PII-23-UAH-LED-01/Universidad Estatal de Sonora/ PT - Journal Article PL - United States TA - Physiol Rep JT - Physiological reports JID - 101607800 SB - IM MH - Humans MH - *Heart Rate/physiology MH - Male MH - Female MH - Adult MH - *Metabolic Syndrome/physiopathology MH - Middle Aged MH - Young Adult MH - Adolescent MH - *Rest/physiology PMC - PMC13334455 OTO - NOTNLM OT - RMSSD OT - autonomic function OT - exercise physiology OT - metabolic health OT - physiological monitoring OT - wearable technology COIS- The authors report no financial or personal relationships with other people or organizations that could inappropriately influence or bias their work. The authors report no conflict of interest. EDAT- 2026/07/06 13:29 MHDA- 2026/07/06 13:30 PMCR- 2026/07/06 CRDT- 2026/07/06 06:14 PHST- 2026/06/22 00:00 [revised] PHST- 2026/06/12 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/07/06 13:30 [medline] PHST- 2026/07/06 13:29 [pubmed] PHST- 2026/07/06 06:14 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - PHY271008 [pii] AID - 10.14814/phy2.71008 [doi] PST - ppublish SO - Physiol Rep. 2026 Jul;14(13):e71008. doi: 10.14814/phy2.71008. PMID- 42404934 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Physical activity awareness and its relationship with motivation among college students: development and validation of a Multidimensional Scale. PG - 1856461 LID - 10.3389/fpubh.2026.1856461 [doi] LID - 1856461 AB - INTRODUCTION: Physical activity (PA) levels remain insufficient among young adults, particularly college students, whose behavioral patterns often persist into adulthood. Although psychological factors are recognized as important determinants of PA behavior, limited attention has been paid to how individuals perceive and interpret their own physical activity and surrounding context. This study aimed to develop and validate a multidimensional scale measuring college students' perceived PA awareness. METHODS: A sequential mixed-method design was employed. In the qualitative phase, focus group interviews were conducted to explore college students' understanding of PA awareness. Based on thematic analysis, four dimensions were identified: personal PA awareness, social support awareness, environmental awareness, and PA recommendation awareness. An initial item pool was then developed and administered to 994 undergraduate students from eight universities. Confirmatory factor analysis (CFA) was conducted to examine the factorial validity of the scale, and internal consistency reliability was assessed using Cronbach's alpha coefficients. RESULTS: CFA supported a stable four-factor structure with acceptable model fit indices (RMSEA = 0.046, SRMR = 0.035, CFI = 0.968). The subscales demonstrated satisfactory internal consistency, with Cronbach's ? values ranging from 0.741 to 0.919. These findings provide empirical support for the reliability and construct validity of the proposed scale. DISCUSSION: The findings suggest that PA awareness is a multidimensional psychological construct reflecting both individual perceptions and contextual influences. The developed scale may contribute to a better understanding of motivational processes underlying physical activity engagement among college students and provide a structured framework for future research on psychological determinants of PA behavior. CI - Copyright (c) 2026 Shangguan, Xie and Hamilton. FAU - Shangguan, Rulan AU - Shangguan R AD - School of Physical Education, South China University of Technology, Guangzhou, China. FAU - Xie, Jiajing AU - Xie J AD - School of Physical Education, South China University of Technology, Guangzhou, China. FAU - Hamilton, Xiaofen AU - Hamilton X AD - Department of Curriculum and Instruction, College of Education, The University of Texas at Austin, Austin, TX, United States. LA - eng PT - Journal Article PT - Validation Study DEP - 20260619 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/psychology/statistics & numerical data MH - Universities MH - Female MH - *Motivation MH - *Exercise/psychology MH - Young Adult MH - Reproducibility of Results MH - Male MH - Focus Groups MH - *Awareness MH - Psychometrics MH - Factor Analysis, Statistical MH - Surveys and Questionnaires/standards MH - Adolescent MH - Qualitative Research MH - Adult MH - *Health Knowledge, Attitudes, Practice PMC - PMC13328250 OTO - NOTNLM OT - college students OT - health behavior OT - mixed methods OT - physical activity awareness OT - psychometric validation OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/06 10:10 MHDA- 2026/07/06 12:41 PMCR- 2026/06/19 CRDT- 2026/07/06 05:40 PHST- 2026/04/15 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/06 12:41 [medline] PHST- 2026/07/06 10:10 [pubmed] PHST- 2026/07/06 05:40 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1856461 [doi] PST - epublish SO - Front Public Health. 2026 Jun 19;14:1856461. doi: 10.3389/fpubh.2026.1856461. eCollection 2026. PMID- 42403893 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260706 LR - 20260813 IS - 1178-6965 (Print) IS - 1178-6965 (Electronic) IS - 1178-6965 (Linking) VI - 19 DP - 2026 TI - Skeletal Muscle Mass and Visceral Fat are Independently Associated with Poorly Controlled Asthma in Children with Obesity: A Cross-Sectional Study. PG - 600914 LID - 10.2147/JAA.S600914 [doi] LID - 600914 AB - PURPOSE: The role of body composition-particularly skeletal muscle mass and visceral fat-in asthma control among children with obesity remains unclear. We compared body composition between children with obesity with and without asthma and examined associations with asthma control. PATIENTS AND METHODS: We enrolled 191 children with obesity aged 6-14 years (85 with asthma, 106 without). Skeletal muscle mass (SMM)-to-body weight (WT) ratio and visceral fat area (VFA) were measured by multi-frequency bioelectrical impedance analysis. Poorly controlled asthma was defined using validated cut-points: Childhood Asthma Control Test /=12). Variables were screened by least absolute shrinkage and selection operator logistic regression; the model was assessed by receiver operating characteristic curve, calibration, and decision-curve analyses. RESULTS: The obese-asthma group had lower SMM/WT than the simple-obesity group (30.17% vs 31.51%, P<0.001); VFA did not differ significantly (P=0.051). Among children with obese-asthma, the poorly controlled group showed lower SMM/WT (P=0.002) and higher VFA (P=0.011). In multivariable analysis, SMM/WT (OR=0.664 per 1%, 95% CI 0.497-0.889, P=0.006), VFA (OR=1.014 per 1 cm(2), 95% CI 1.001-1.028, P=0.034), maximal mid-expiratory flow (MMEF) percent predicted (OR=1.073, 95% CI 1.007-1.143, P=0.029), and extracellular water to total body water ratio (ECW/TBW) (OR=1.719 per 0.01, 95% CI 1.000-2.956, P=0.050) were independently associated with poorly controlled asthma. The area under the curve (AUC) was 0.807 (95% CI 0.709-0.905; sensitivity 76.9%, specificity 75.8%; mean absolute error 0.027). CONCLUSION: Lower SMM/WT, higher VFA, higher MMEF percent predicted, and higher ECW/TBW were independently associated with poorly controlled asthma in children with obesity. The four-variable model showed good discrimination (AUC=0.807). These exploratory associations require prospective validation before clinical application. CI - (c) 2026 Wang et al. FAU - Wang, Zhiyuan AU - Wang Z AUID- ORCID: 0000-0001-7990-9740 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Zhao, Junlin AU - Zhao J AUID- ORCID: 0009-0002-9080-9622 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Wang, Yanan AU - Wang Y AUID- ORCID: 0009-0008-3176-160X AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Dai, Qianqian AU - Dai Q AUID- ORCID: 0009-0005-7647-0812 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Qu, Shengmeng AU - Qu S AUID- ORCID: 0009-0004-2746-3408 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Ru, Liang AU - Ru L AUID- ORCID: 0009-0002-2200-3889 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. LA - eng PT - Journal Article DEP - 20260629 PL - New Zealand TA - J Asthma Allergy JT - Journal of asthma and allergy JID - 101543450 PMC - PMC13332121 OAB - WHY DID WE DO THIS STUDY? Obesity and asthma are both becoming more common in children. Children who have both conditions may have less well-controlled asthma. Doctors usually record only height and weight, which do not show how much muscle a child has or where body fat is stored. We wanted to learn whether measuring muscle and fat separately could help explain why some children with obesity have poorer asthma control. WHAT DID WE DO? We studied 191 children with obesity aged 6-14 years. We used a body-composition scanner to estimate muscle mass and visceral fat (the fat stored around internal organs). We compared children with and without asthma, and-among those with asthma-children whose symptoms were poorly controlled with the rest of the asthma group, who had comparatively better symptom control. WHAT DID WE FIND? Children with obesity and asthma had less muscle relative to their body weight than children with obesity alone. Among the children with asthma, those whose asthma was poorly controlled tended to have lower muscle mass and higher visceral fat. Using these measures, we built a preliminary tool to help estimate which children might be at higher risk of poor asthma control. WHAT DOES THIS MEAN? Looking at body composition, rather than weight alone, may give doctors additional information about asthma in children with obesity, and could support more individualized care in the future. Further studies in other groups of children are needed before these measures can be used in routine practice. OABL- eng OTO - NOTNLM OT - asthma OT - pediatric obesity OT - sarcopenic obesity OT - skeletal muscle mass OT - visceral fat COIS- The authors declare no competing interests in this work. EDAT- 2026/07/06 10:10 MHDA- 2026/07/06 10:11 PMCR- 2026/06/29 CRDT- 2026/07/06 05:28 PHST- 2026/02/03 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/06 10:11 [medline] PHST- 2026/07/06 10:10 [pubmed] PHST- 2026/07/06 05:28 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 600914 [pii] AID - 10.2147/JAA.S600914 [doi] PST - epublish SO - J Asthma Allergy. 2026 Jun 29;19:600914. doi: 10.2147/JAA.S600914. eCollection 2026. PMID- 42403888 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260706 LR - 20260813 IS - 1178-6965 (Print) IS - 1178-6965 (Electronic) IS - 1178-6965 (Linking) VI - 19 DP - 2026 TI - A Clinical Nomogram for Predicting Early Response to Biologics in Pediatric Allergic Asthma with Comorbid Allergic Rhinitis. PG - 604654 LID - 10.2147/JAA.S604654 [doi] LID - 604654 AB - BACKGROUND: The coexistence of allergic rhinitis (AR) and allergic asthma poses a significant burden on pediatric health. While biologics targeting type 2 inflammation have revolutionized treatment, individual responses vary significantly. There is a lack of practical tools to predict early therapeutic response before initiation. This study aimed to identify key baseline predictors and construct a nomogram to personalize the prediction of early response to biologics in children with AR and allergic asthma. METHODS: This retrospective cohort study included 246 children (recruited between January 2021 and August 2025) diagnosed with moderate-to-severe allergic AR and allergic asthma who received biologic therapy (Omalizumab or Dupilumab). Early response was assessed at 16 weeks based on a composite outcome involving the Asthma Control Test (ACT), visual analog scale (VAS) for nasal symptoms, and exacerbation history. Independent predictors were identified using LASSO regression and multivariate logistic regression analysis to build a nomogram. The model's performance was evaluated using the concordance index (C-index), calibration curves, and decision curve analysis (DCA). RESULTS: Of the 246 patients, 164 (66.7%) were classified as early responders. Multivariate analysis identified baseline fractional exhaled nitric oxide (FeNO), blood eosinophil count (EOS), total IgE levels, comorbidity of atopic dermatitis (AD), and Body Mass Index (BMI) as independent predictors. The developed nomogram demonstrated good discrimination with a C-index of 0.88 (95% CI: 0.83-0.93) in the training cohort and 0.85 (95% CI: 0.78-0.92) in the validation cohort. Calibration curves showed excellent agreement between predicted and observed probabilities. DCA indicated significant clinical net benefit across a wide range of threshold probabilities. CONCLUSION: We successfully developed a novel nomogram incorporating baseline type 2 inflammatory endotypes and AD comorbidity to predict early response to biologics in pediatric patients with allergic asthma and comorbid AR. This tool offers clinicians a practical method to screen potential "super-responders", thereby optimizing therapeutic decision-making and resource allocation. CI - (c) 2026 Wang et al. FAU - Wang, Lixin AU - Wang L AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Kang, Zhaopeng AU - Kang Z AD - Health Management Center, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Ma, Jun AU - Ma J AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Wang, Chuanxi AU - Wang C AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Jiang, Wanjin AU - Jiang W AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Huang, Jingjiang AU - Huang J AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Liu, Shaofeng AU - Liu S AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. LA - eng PT - Journal Article DEP - 20260630 PL - New Zealand TA - J Asthma Allergy JT - Journal of asthma and allergy JID - 101543450 PMC - PMC13332785 OTO - NOTNLM OT - allergic asthma OT - allergic rhinitis OT - biological therapy OT - nomogram OT - pediatrics OT - type 2 inflammation COIS- Lixin Wang and Zhaopeng Kang are co-first authors for this study. The authors declare that they have no competing interests for this work. EDAT- 2026/07/06 10:10 MHDA- 2026/07/06 10:11 PMCR- 2026/06/30 CRDT- 2026/07/06 05:28 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/06 10:11 [medline] PHST- 2026/07/06 10:10 [pubmed] PHST- 2026/07/06 05:28 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 604654 [pii] AID - 10.2147/JAA.S604654 [doi] PST - epublish SO - J Asthma Allergy. 2026 Jun 30;19:604654. doi: 10.2147/JAA.S604654. eCollection 2026. PMID- 42403308 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 83 IP - 4 DP - 2026 Oct TI - Heterogeneous outcomes in pediatric potential celiac disease: A multicenter longitudinal study. PG - 717-722 LID - 10.1002/jpn3.70501 [doi] AB - OBJECTIVES: Potential celiac disease (PCD) is defined by positive celiac serology without villous atrophy. We aimed to study the outcome of children with PCD consuming a gluten-containing diet (GCD) over time. METHODS: Children diagnosed with PCD between December 2018 and January 2022, in three pediatric gastroenterology centers, were longitudinally followed. Data were collected until October 2024, with a minimum follow-up of 12 months, unless celiac disease (CeD) was diagnosed earlier. Baseline data included demographics, celiac serology, and histological findings. Follow-up data included serology and biopsy results when performed. RESULTS: The cohort included 88 patients with PCD, with a mean follow-up of 39 (range 12- 69) months. During this period, 17 (19.5%) patients progressed to CeD. Normalization of anti-tissue transglutaminase antibodies (tTG), while continuing a GCD, occurred in 33/88 (37.5%) while the rest remained with PCD. Specifically, among 16 patients with tTG levels >x10 upper limit of normal (ULN) at PCD diagnosis, three (18.8%) progressed to CeD, six (37.5%) normalized tTG while continued GCD, and the rest remained unchanged. Asymptomatic patients had higher rates of tTG normalization (61.9% vs. 35.8%, p = 0.0011). Neither tTG levels, nor having Marsh 1 histology, had a significant effect on PCD outcomes. CONCLUSIONS: Among pediatric patients with PCD, during a mean follow-up of 3.3 years, one-fifth progressed to CeD. Baseline serology levels do not reliably predict future mucosal deterioration. Over a third of children with PCD may achieve serological normalization while maintaining a GCD. This heterogeneous pattern of PCD warrants periodic serological and histological follow-up. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Laxer, Barak AU - Laxer B AUID- ORCID: 0009-0003-6425-4106 AD - Pediatric Division, Kaplan Medical Center, Rehovot, Israel. FAU - Rinawi, Firas AU - Rinawi F AUID- ORCID: 0000-0001-7634-5310 AD - Pediatric Gastroenterology Unit Emek Medical Centre, Afula, Israel. AD - The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. FAU - Ziv-Sokolovskaya, Nadya AU - Ziv-Sokolovskaya N AD - Institute of Pathology, Kaplan Medical Center, Rehovot, Israel. FAU - Shamir, Raanan AU - Shamir R AD - Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach-Tikva, Israel. AD - Gray Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. FAU - Kori, Michal AU - Kori M AD - Pediatric Gastroenterology, Kaplan Medical Center, Rehovot, Israel. AD - Faculty of Medicine, Hebrew University Jerusalem, Jerusalem, Israel. FAU - Guz-Mark, Anat AU - Guz-Mark A AUID- ORCID: 0000-0003-4175-7432 AD - Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach-Tikva, Israel. AD - Gray Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. LA - eng GR - None/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260706 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - 0 (anti-transglutaminase autoantibody) RN - 0 (Autoantibodies) RN - EC 2.3.2.13 (Transglutaminases) SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Autoantibodies/blood MH - Biopsy MH - *Celiac Disease/diet therapy/diagnosis/pathology/blood MH - Diet, Gluten-Free MH - Disease Progression MH - Follow-Up Studies MH - Longitudinal Studies MH - Transglutaminases/immunology PMC - PMC13646031 OTO - NOTNLM OT - PCD OT - follow-up OT - histology OT - serology COIS- The authors declare no conflicts of interest. EDAT- 2026/07/06 06:31 MHDA- 2026/10/08 05:31 PMCR- 2026/10/08 CRDT- 2026/07/06 04:53 PHST- 2026/05/20 00:00 [revised] PHST- 2026/02/23 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/06 06:31 [pubmed] PHST- 2026/07/06 04:53 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - JPN370501 [pii] AID - 10.1002/jpn3.70501 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Oct;83(4):717-722. doi: 10.1002/jpn3.70501. Epub 2026 Jul 6. PMID- 42403118 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1681-7168 (Electronic) IS - 1022-386X (Linking) VI - 36 IP - 7 DP - 2026 Jul TI - Stature Estimation from Foot Anthropometry in a Pakistani Cohort. PG - 841-845 LID - 10.29271/jcpsp.2026.07.841 [doi] AB - OBJECTIVE: To investigate the relationships between an individual's height and various foot dimensions and to assess the statistical differences between right and left foot measurements. STUDY DESIGN: A cross-sectional study. Place and Duration of the Study: Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan, from August to October 2024. METHODOLOGY: Healthy individuals of either gender, aged 18 to 60 years, with no physical disability, and who could stand upright without assistance were invited to participate. Individuals with any visible spinal or foot deformity were excluded. Participants were assessed for stature and foot measurements. RESULTS: A total of 112 participants were included in this study. The mean height for both genders was 65.185 +/- 3.7482 inches; the mean left and right foot breadths were 4.566 +/- 2.8491 and 4.481 +/- 1.5324 inches, respectively; the mean left foot length (LFL) and right foot length (RFL) were 9.762 +/- 1.3573 and 9.591 +/- 1.5373 inches, respectively. Foot length (FL) in males (RFL: r = 0.129, LFL: r = 0.224) and females (RFL: r = 0.158, LFL: r = 0.519) had the strongest correlation of all the variables. Specifically, the LFL of females showed a significant correlation with their stature (p <0.001). CONCLUSION: This study corroborates the significant correlation between foot measurements and stature, particularly emphasising the reliability of FL as a predictor of height. KEY WORDS: Stature, Foot, Estimation, Foot anthropometry, Pakistan. FAU - Irshad, Raheela AU - Irshad R AD - Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan. FAU - Baig, Ramsha Urooj AU - Baig RU AD - Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan. FAU - Naz, Ramlah AU - Naz R AD - Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan. FAU - Fatima, Mehreen AU - Fatima M AD - Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan. LA - eng PT - Journal Article PL - Pakistan TA - J Coll Physicians Surg Pak JT - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JID - 9606447 SB - IM MH - Humans MH - Male MH - Female MH - *Foot/anatomy & histology MH - Pakistan MH - *Body Height MH - Adult MH - *Anthropometry/methods MH - Cross-Sectional Studies MH - Middle Aged MH - Adolescent MH - Young Adult EDAT- 2026/07/06 06:31 MHDA- 2026/07/06 06:32 CRDT- 2026/07/06 03:47 PHST- 2025/09/22 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/07/06 06:32 [medline] PHST- 2026/07/06 06:31 [pubmed] PHST- 2026/07/06 03:47 [entrez] AID - 040579197 [pii] AID - 10.29271/jcpsp.2026.07.841 [doi] PST - ppublish SO - J Coll Physicians Surg Pak. 2026 Jul;36(7):841-845. doi: 10.29271/jcpsp.2026.07.841. PMID- 42402933 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260901 IS - 1526-3231 (Electronic) IS - 0749-8063 (Linking) VI - 42 IP - 9 DP - 2026 Sep TI - Lateral Femoral Condyle Angle Is an Anatomic Risk Factor for Anterior Cruciate Ligament Primary Injury and Secondary Graft Rerupture. PG - 1748-1760 LID - 10.1002/arj.70322 [doi] AB - PURPOSE: To define the lateral femoral condylar angle (LFCA)-a parameter measuring condylar inclination-and assess its predictive capacity for primary and recurrent anterior cruciate ligament (ACL) injuries. METHODS: Patients aged 18 to 50 years who underwent primary ACL reconstruction between 2017 and 2022 were screened. Those with graft rerupture were matched 1:1:1 by sex, age, body mass index, and meniscal status to ACL-intact controls and patients without graft failure during a minimum 48-month follow-up. LFCA was measured as the angle between the long axis of the distal femur and the axis of the lateral femoral condyle, alongside 38 established parameters using preoperative 3.0-T magnetic resonance imaging scans. Intergroup differences were assessed with one-way analysis of variance; multivariate regression and receiver operating characteristic analyses identified independent predictors and evaluated predictive performance. RESULTS: The study included 540 patients (180 per group: primary ACL injury, rerupture, controls). One-way analysis of variance revealed a significant gradient in LFCA across controls (81.3 degrees , 95% CI: 80.8-81.8 degrees ), primary injuries (81.9 degrees , 95% CI: 81.5-82.3 degrees ), and reruptures (84.2 degrees , 95% CI: 83.7-84.6 degrees ) (P < .001). In multivariate models adjusted for baseline factors, LFCA independently predicted primary injury (odds ratio [OR] = 1.27, 95% CI: 1.13-1.42, P < .001; area under the curve [AUC] = .576) and rerupture (OR = 1.46, 95% CI: 1.21-1.76, P < .001; AUC = .704). Combined models incorporating LFCA with tibial slopes, notch angle, and notch height achieved an AUC of .847 for primary injury prediction, whereas models with LFCA, lateral condylar flexion curvature radius, slope asymmetry, and tibial AP distance reached an AUC of .817 for rerupture. LFCA alone with lateral condylar flexion curvature radius yielded an AUC of .777 for rerupture prediction. Sex-stratified analyses confirmed LFCA predicted rerupture in both male patients (OR = 1.44, 95% CI: 1.19-1.75) and female patients (OR = 1.49, 95% CI: 1.16-1.92), and primary injury in male patients (OR = 1.30, 95% CI: 1.15-1.48). CONCLUSIONS: LFCA is an independent predictor of ACL injury, showing particular strength in identifying Asian patients at high risk for graft rerupture. LEVEL OF EVIDENCE: Level III, retrospective case-control study. CI - (c) 2026 the Arthroscopy Association of North America. FAU - Wang, Ding-Yu AU - Wang DY AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Liu, Jia-Xin AU - Liu JX AUID- ORCID: 0009-0009-6600-7970 AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Du, Xin-Wei AU - Du XW AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Wang, Ling-Xiao AU - Wang LX AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Zhang, Song-Lin AU - Zhang SL AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Jiang, Dong AU - Jiang D AUID- ORCID: 0000-0003-4380-7683 AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. LA - eng GR - L242104/Beijing Natural Science Foundation/ GR - 82441025/National Natural Science Foundation of China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260705 PL - United States TA - Arthroscopy JT - Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association JID - 8506498 SB - IM MH - Humans MH - *Anterior Cruciate Ligament Injuries/surgery/diagnostic imaging MH - Male MH - Adult MH - Female MH - Risk Factors MH - Recurrence MH - *Femur/diagnostic imaging/anatomy & histology MH - *Anterior Cruciate Ligament Reconstruction/methods MH - Middle Aged MH - Young Adult MH - Magnetic Resonance Imaging MH - Adolescent MH - Retrospective Studies EDAT- 2026/07/06 06:32 MHDA- 2026/08/25 17:35 CRDT- 2026/07/06 02:33 PHST- 2025/06/10 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/08/25 17:35 [medline] PHST- 2026/07/06 06:32 [pubmed] PHST- 2026/07/06 02:33 [entrez] AID - 10.1002/arj.70322 [doi] PST - ppublish SO - Arthroscopy. 2026 Sep;42(9):1748-1760. doi: 10.1002/arj.70322. Epub 2026 Jul 5. PMID- 42402486 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Dental age assessment: orthopantomogram-based comparison of traditional methods and artificial intelligence in the adult population. PG - 4167-4179 LID - 10.1007/s00414-026-03908-9 [doi] AB - Dental age estimation in adults represents an important component of forensic odontology and medicolegal practice. Recent artificial intelligence (AI) approaches have demonstrated improved performance compared to traditional morphometric techniques. This study aimed to compare the reliability and accuracy of three conventional dental age estimation methods with an AI-based approach. A total of 1000 digital orthopantomograms of adults aged 18-79 years with known chronological age were retrieved from the Department of Dental Anthropology database at the University of Zagreb School of Dental Medicine. Dental age was assessed using Kvaal's, Drusini's, and Cameriere's methods in ImageJ, and compared with an AI-based convolutional neural network model developed at the University of Zagreb Faculty of Electrical Engineering and Computing. Intraclass correlation coefficient (ICC) analysis and Bland-Altman plots demonstrated excellent reliability of the AI-based method (ICC = 0.965), with a mean bias of + 4.31 years and superior precision (CV = 4.34%, SEP = 3.64 years). In contrast, traditional methods showed poor reliability: Cameriere (ICC = 0.376; bias of + 9.16 years), Drusini (ICC = 0.331; bias of + 2.21 years), and Kvaal (ICC = 0.310; bias of + 15.7 years). Applicability rates were highest for the AI-based method (91.1%), followed by Cameriere (70.8%), Kvaal (63.1%), and Drusini (39.5%). Although the AI model demonstrated a systematic tendency toward age overestimation, it outperformed conventional methods and shows strong potential for application in forensic dental practice. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Tomljenovic, Filipa AU - Tomljenovic F AUID- ORCID: 0009-0008-6629-3244 AD - Department of Dental Anthropology, University of Zagreb School of Dental Medicine, Zagreb, Croatia. fspehar@sfzg.hr. FAU - Vodanovic, Marin AU - Vodanovic M AUID- ORCID: 0000-0002-1935-8657 AD - Department of Dental Anthropology, University of Zagreb School of Dental Medicine, Zagreb, Croatia. AD - University Hospital Centre Zagreb, Zagreb, Croatia. FAU - Sribar, Andrej AU - Sribar A AUID- ORCID: 0000-0002-6517-9895 AD - Department of Dental Anthropology, University of Zagreb School of Dental Medicine, Zagreb, Croatia. AD - Dubrava University Hospital, Zagreb, Croatia. FAU - Brkic, Hrvoje AU - Brkic H AUID- ORCID: 0000-0003-4284-7739 AD - Department of Dental Anthropology, University of Zagreb School of Dental Medicine, Zagreb, Croatia. AD - University Hospital Centre Zagreb, Zagreb, Croatia. AD - University of Lisbon Faculty of Dental Medicine, Lisbon, Portugal. FAU - Milosevic, Denis AU - Milosevic D AUID- ORCID: 0000-0002-4214-178X AD - Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia. FAU - Subasic, Marko AU - Subasic M AUID- ORCID: 0000-0002-4321-4557 AD - Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260706 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Adult MH - *Radiography, Panoramic MH - Middle Aged MH - Adolescent MH - Aged MH - *Artificial Intelligence MH - Young Adult MH - Reproducibility of Results MH - Female MH - Male MH - Convolutional Neural Networks MH - Image Processing, Computer-Assisted OTO - NOTNLM OT - Artificial intelligence OT - Convolutional neural network OT - Deep learning OT - Dental age estimation OT - Forensic odontology OT - Panoramic radiography COIS- Declarations. Ethics approval: The study protocol was reviewed and approved by the Ethics Committee of the School of Dental Medicine, University of Zagreb (approval no. 05-PA-12-3/2024; December 10, 2024). The study was conducted in accordance with institutional guidelines and the Declaration of Helsinki. Informed consent: This study used retrospectively collected, fully anonymised radiographic data obtained during routine clinical practice. The Ethics Committee waived the requirement for informed consent due to the study's retrospective nature and the use of anonymised data. The study complied with the Declaration of Helsinki. Clinical trial number: not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/06 00:30 MHDA- 2026/10/12 17:30 CRDT- 2026/07/05 23:02 PHST- 2026/04/03 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/06 00:30 [pubmed] PHST- 2026/07/05 23:02 [entrez] AID - 10.1007/s00414-026-03908-9 [pii] AID - 10.1007/s00414-026-03908-9 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):4167-4179. doi: 10.1007/s00414-026-03908-9. Epub 2026 Jul 6. PMID- 42402421 OWN - NLM STAT- MEDLINE DCOM- 20260705 LR - 20260813 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 4 DP - 2026 Jul TI - Translation and Cross-Cultural Adaptation of the Family Nutrition and Physical Activity Screening Tool for Portuguese Well-Child Visits. PG - e70316 LID - 10.1111/cch.70316 [doi] LID - e70316 AB - BACKGROUND: Family environments play a critical role in shaping children's lifestyle behaviours that influence obesity risk. However, culturally validated instruments to assess these behaviours are lacking in Portuguese primary care. AIM: This study aims to translate and culturally adapt the Family Nutrition and Physical Activity (FNPA) screening tool for use in Portugal (FNPA-PT) and to evaluate its face and content validity through cognitive interviews with parents attending well-child visits. DESIGN AND METHODS: An exploratory, descriptive study followed internationally endorsed guidelines (Beaton; MAPI) for translation and cross-cultural adaptation. The process comprised seven stages: forward translations, synthesis, back translations, comparisons of back translations, expert committee review, cognitive debriefing and final proofreading. Ten parents of five-year-old children attending a public primary care centre in Lisbon completed the FNPA-PT while participating in individual cognitive interviews. Data were analysed using Content Analysis, guided by Tourangeau's four-stage response model. RESULTS: Semantic equivalence between forward and back translations was high (85% of items with satisfactory or perfect equivalence). Minor linguistic and cultural adaptations were introduced to improve clarity and contextual relevance. Cognitive interviews indicated that the FNPA-PT was well understood, acceptable to parents, and feasible to complete during well-child visits. Parents valued the questionnaire's comprehensiveness and its potential to enhance awareness and stimulate discussion about family health behaviours. Minor revisions addressed comprehension issues in three items related to milk consumption, screen time and sleep. CONCLUSIONS: The FNPA-PT demonstrated strong face and content validity and high acceptability among Portuguese parents. It provides a culturally appropriate, family-centred tool for health professionals to support early identification of obesogenic environments and to guide preventive counselling in primary care. The study also offers a transparent methodological pathway for translating and adapting behavioural measures across languages and settings. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Rodrigues, Sonia Borges AU - Rodrigues SB AUID- ORCID: 0000-0002-9453-4876 AD - Nursing Research, Innovation and Development Centre of Lisbon (CIDNUR), School of Nursing, Universidade de Lisboa, Lisbon, Portugal. AD - Department of Child and Adolescent Nursing, School of Nursing, Universidade de Lisboa, Lisbon, Portugal. FAU - Rodrigues, Ricardo Borges AU - Rodrigues RB AUID- ORCID: 0000-0002-6720-2905 AD - Department of Psychology, Instituto Universitario de Lisboa (Iscte-IUL), Lisbon, Portugal. AD - Centro de Investigacao e Intervencao Social (CIS-Iscte), Lisbon, Portugal. FAU - Saboga-Nunes, Luis AU - Saboga-Nunes L AD - Department of Public Health, Institute of Sociology, University of Education Freiburg, Freiburg, Germany. AD - UNESCO Chair and WHO Collaborating Center in Global Health & Education, Paris, France. FAU - Barros, Luisa AU - Barros L AD - Faculty of Psychology, University of Lisbon, Lisbon, Portugal. AD - CICPsi, Center for Research in Psychological Science, University of Lisbon, Lisbon, Portugal. FAU - Salantera, Sanna AU - Salantera S AUID- ORCID: 0000-0003-2529-6699 AD - Department of Nursing Science, Faculty of Medicine, University of Turku, Turku, Finland. AD - Turku University Hospital, Turku, Finland. LA - eng PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Portugal/epidemiology MH - Child, Preschool MH - Male MH - Female MH - Translations MH - Cross-Cultural Comparison MH - Surveys and Questionnaires MH - Reproducibility of Results MH - *Exercise MH - Primary Health Care MH - Parents/psychology MH - *Pediatric Obesity/prevention & control PMC - PMC13382483 OTO - NOTNLM OT - cognitive interviews OT - cultural adaptation OT - family nutrition and physical activity (FNPA) OT - paediatric obesity OT - patient-reported outcome measures OT - primary health care OT - well-child visits COIS- The authors declare no conflicts of interest. EDAT- 2026/07/06 04:10 MHDA- 2026/07/06 04:11 PMCR- 2026/07/20 CRDT- 2026/07/05 21:42 PHST- 2026/05/29 00:00 [revised] PHST- 2025/11/07 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/06 04:11 [medline] PHST- 2026/07/06 04:10 [pubmed] PHST- 2026/07/05 21:42 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - CCH70316 [pii] AID - 10.1111/cch.70316 [doi] PST - ppublish SO - Child Care Health Dev. 2026 Jul;52(4):e70316. doi: 10.1111/cch.70316. PMID- 42401849 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1471-2377 (Electronic) IS - 1471-2377 (Linking) VI - 26 IP - 1 DP - 2026 Jul 4 TI - Screen time patterns and cognitive screening outcomes (MoCA-Ina) in adolescents: a cross-sectional study. LID - 10.1186/s12883-026-05128-5 [doi] LID - 609 AB - BACKGROUND: Adolescent screen exposure is increasing, yet clinically interpretable thresholds for cognitive risk are unclear. This study examined associations between daily screen time and cognitive screening performance and derived a screen-time cutoff associated with cognitive impairment. METHODS: We conducted an observational cross-sectional study (March-April 2022) at a private junior high school in Indonesia during online learning. Students completed digital questionnaires reporting educational and recreational screen time and a directly reported overall estimate; a computed overall (educational + recreational) was generated to assess reporting consistency. Cognitive function was assessed using the MoCA-Ina, with < 24 as the primary impairment threshold based on recent psychometric evidence favoring lower cutoffs for improved classification accuracy. RESULTS: Sixty-seven adolescents were included (34 girls, 50.7%; 33 boys, 49.3%), with median age 13.0 years (12.0-16.0) and median MoCA-Ina 25.0 (19.0-31.0). MoCA-Ina did not differ by sex (girls 25.0 [19.0-31.0] vs. boys 26.0 [20.0-30.0]; p = 0.244). Recreational screen time correlated inversely with MoCA-Ina (rho = -0.446, p < 0.001), as did overall screen time (rho = -0.360, p = 0.003), whereas educational screen time was not associated (rho = -0.061, p = 0.624). In adjusted regression, overall screen time remained negatively associated with MoCA-Ina (beta = -0.24 per hour/day; 95% CI - 0.41 to - 0.07; p = 0.007), while age was positively associated (beta = 0.96; 95% CI 0.07 to 1.85; p = 0.034). All variance inflation factors were below 2.5, indicating no substantial multicollinearity. ROC analysis showed fair discrimination (AUC 0.66; optimism-corrected AUC after bootstrap internal validation [1,000 resamples]: 0.63) with an optimal cutoff > 8.97 h/day (sensitivity 83.3%, specificity 48.8%, PPV 47.6%, NPV 84.0%); risk of impairment was higher above the cutoff (RR 2.98; 95% CI 1.15-7.72; p = 0.010; OR 4.77; 95% CI 1.40-16.31). CONCLUSIONS: High daily screen exposure was associated with poorer cognitive screening performance. The > 8.97-hour/day threshold represents a preliminary, hypothesis-generating cutoff that may help identify adolescents at elevated likelihood of cognitive impairment, pending external validation in larger, more diverse samples. TRIAL REGISTRATION: 071/K-LKJ/ETIK/II/2022. CI - (c) 2026. The Author(s). FAU - Gunawan, Pricilla Yani AU - Gunawan PY AUID- ORCID: 0000-0002-5620-3267 AD - Department of Neurology, Faculty of Medicine, Universitas Pelita Harapan, Jl. Jenderal Sudirman No.15, Tangerang, Banten, 15810, Indonesia. pricilla.yani@outlook.com. AD - Department of Neurology, Siloam Hospitals Lippo Village, Tangerang, Indonesia. pricilla.yani@outlook.com. FAU - Andraina, Andraina AU - Andraina A AD - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia. FAU - Wijaya, Jeremiah Hilkiah AU - Wijaya JH AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. FAU - Arjuna, Yang Yang Endro AU - Arjuna YYE AUID- ORCID: 0000-0002-5916-1453 AD - Department of Neurology, Siloam Hospitals Lippo Village, Tangerang, Indonesia. AD - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia. FAU - Gunawan, Patricia Yulita AU - Gunawan PY AUID- ORCID: 0000-0002-3287-0671 AD - Department of Paediatrics, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia. AD - Department of Paediatrics, University of Oxford, Oxford, UK. LA - eng PT - Journal Article PT - Observational Study DEP - 20260704 PL - England TA - BMC Neurol JT - BMC neurology JID - 100968555 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Screen Time MH - Adolescent MH - Female MH - Child MH - *Cognitive Dysfunction/diagnosis/psychology MH - *Cognition MH - Media Exposure MH - Surveys and Questionnaires MH - Neuropsychological Tests MH - Indonesia PMC - PMC13613649 OTO - NOTNLM OT - Adolescent OT - Cognition OT - ROC curve OT - Screen time COIS- Declarations. Ethics approval and consent to participate: This observational cross-sectional study was reviewed and approved by the institutional ethics committee of the Faculty of Medicine, Pelita Harapan University (Approval No.: 071/K-LKJ/ETIK/II/2022). The study was conducted in accordance with the Declaration of Helsinki and applicable local regulations. Written informed consent to participate was obtained from all participants. For any participant under the age of 16 years, written informed consent was obtained from their parent or legal guardian prior to participation. Informed consent was obtained from all individual participants included in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/05 00:37 MHDA- 2026/09/25 05:31 PMCR- 2026/07/04 CRDT- 2026/07/04 23:34 PHST- 2026/02/10 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/09/25 05:31 [medline] PHST- 2026/07/05 00:37 [pubmed] PHST- 2026/07/04 23:34 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - 10.1186/s12883-026-05128-5 [pii] AID - 5128 [pii] AID - 10.1186/s12883-026-05128-5 [doi] PST - epublish SO - BMC Neurol. 2026 Jul 4;26(1):609. doi: 10.1186/s12883-026-05128-5. PMID- 42401398 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 226 DP - 2026 Nov 1 TI - Gratitude for food as a driver of improved dietary behaviors: A scoping review. PG - 108703 LID - S0195-6663(26)00265-5 [pii] LID - 10.1016/j.appet.2026.108703 [doi] AB - Gratitude for food (GF) is a positive emotional response linked to healthier dietary behaviors, mindful eating, and food waste reduction. Despite increasing research interest internationally and in Japan, existing research has not been systematically integrated, and measurement tools remain fragmented. This study aims to systematically map and synthesize international and Japanese studies on GF, clarify current knowledge, detail the characteristics and thematic focuses of existing research, critically examine the variety and validation status of GF measurement tools, and identify the cultural and methodological gaps within the literature. A scoping review following PRISMA-ScR guidelines was conducted. Searches of five databases-SCOPUS, PubMed, EBSCO host, Ichushi-web, and J-stage-in English and Japanese were conducted covering publications from 1995 to 2025. Data extraction included study characteristics, GF measurement tools, and intervention details. Quantitative text mining analyzed the research themes. Thirty-nine studies were included, encompassing cross-sectional, intervention, qualitative, mixed-methods, and scale development designs. Five research focus clusters emerged: school lunches, nutrition education programs, food waste, mindful eating, and scale development. Five validated GF scales were identified, some with cross-cultural adaptations, but their use and validation were fragmented. Intervention studies were predominantly non-randomized controlled trials in Japan, focusing on school-aged children, with mixed evidence on effectiveness. GF is a culturally nuanced construct with important implications for promoting healthier dietary habits, reducing food waste, and fostering mindful eating. Future research should focus on harmonizing measurement tools and conducting rigorous intervention studies to advance the field. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Kawasaki, Yui AU - Kawasaki Y AD - Institute for SDGs Promotion, Organization for Social Implementation of Sustainability, Ochanomizu University, 2-1-1 Otsuka Bunkyo-ku, Tokyo, 112-8610, Japan. Electronic address: kawasaki.yui@ocha.ac.jp. FAU - Nagao-Sato, Sayaka AU - Nagao-Sato S AD - Graduate School of Public Health, Shizuoka Graduate University of Public Health, 4-27-2, Kita Ando, Aoi-ku, Shizuoka, 420-0881, Japan. Electronic address: sysato@s-sph.ac.jp. FAU - Yoshii, Emi AU - Yoshii E AD - Department of Food and Health Sciences, Faculty of Health and Human Development, The University of Nagano, Japan. Electronic address: yoshii.emi@u-nagano.ac.jp. FAU - Akamatsu, Rie AU - Akamatsu R AD - Natural Science Division, Faculty of Core Research, Ochanomizu University, 2-1-1 Otsuka Bunkyo-ku, Tokyo, 112-8610, Japan. Electronic address: akamatsu.rie@ocha.ac.jp. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260704 PL - England TA - Appetite JT - Appetite JID - 8006808 RN - 0 (Food Loss and Waste) SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - *Diet, Healthy/psychology MH - Japan MH - Food Loss and Waste MH - Child MH - Mindfulness MH - *Food MH - Emotions MH - Health Behavior OTO - NOTNLM OT - Dietary behavior OT - Food waste OT - Gratitude OT - Mindful eating OT - Nutrition education COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yui Kawasaki reports financial support was provided by the Moritani Scholarship Foundation [no grant number]. EDAT- 2026/07/05 00:37 MHDA- 2026/08/08 00:40 CRDT- 2026/07/04 19:34 PHST- 2026/03/01 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/08 00:40 [medline] PHST- 2026/07/05 00:37 [pubmed] PHST- 2026/07/04 19:34 [entrez] AID - S0195-6663(26)00265-5 [pii] AID - 10.1016/j.appet.2026.108703 [doi] PST - ppublish SO - Appetite. 2026 Nov 1;226:108703. doi: 10.1016/j.appet.2026.108703. Epub 2026 Jul 4. PMID- 42400688 OWN - NLM STAT- MEDLINE DCOM- 20260704 LR - 20260813 IS - 1573-7322 (Electronic) IS - 1382-4147 (Print) IS - 1382-4147 (Linking) VI - 31 IP - 1 DP - 2026 Jul 4 TI - Mavacamten in adolescent obstructive hypertrophic cardiomyopathy: SCOUTing a way forward. LID - 10.1007/s10741-026-10655-x [doi] LID - 78 AB - Paediatric obstructive hypertrophic cardiomyopathy (oHCM) is a rare inherited cardiac disease that may present from childhood through adolescence and is associated with substantial long-term morbidity and mortality. Its management is based largely on observational studies and clinical experience and currently focusses on symptom improvement through medical therapy and, when indicated, septal reduction therapy to alleviate left ventricular outflow tract (LVOT) obstruction. In adult oHCM, mavacamten has established cardiac myosin inhibition as an effective strategy to reduce LVOT obstruction, but paediatric trial evidence has been lacking. The SCOUT-HCM trial is the first randomised placebo-controlled trial in adolescents to investigate the efficacy and safety of mavacamten for symptomatic oHCM. Among 44 adolescents (mean age 14.7 +/- 1.7 years) mavacamten significantly reduced Valsalva-provoked LVOT gradients at 28 weeks, confirming short-term physiological efficacy. Secondary and exploratory findings, including NYHA functional class, cardiac structure and biomarkers, showed a trend to improvement, without a signal of left ventricular systolic dysfunction. The positive results of SCOUT-HCM, align with larger and longer adult oHCM trials and are likely to influence clinical practice, supporting a cautious integration of mavacamten in adolescent oHCM management. Longer follow-up and broader paediatric studies should determine durability of benefit, validated patient-reported outcomes, exercise capacity, arrhythmia burden, long-term safety and the need for septal reduction therapy in paediatric oHCM. CI - (c) 2026. The Author(s). FAU - Bennetts, Joshua D AU - Bennetts JD AD - College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Ngo, Doan T M AU - Ngo DTM AD - College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Cheema, Baljash AU - Cheema B AD - Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Hosseini, Kaveh AU - Hosseini K AD - Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark. AD - Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Verheyen, Nicolas AU - Verheyen N AD - Division of Cardiology, Department of Internal Medicine, University Heart Center, Medical University of Graz, Graz, Austria. FAU - Santner, Viktoria AU - Santner V AD - Division of Cardiology, Department of Internal Medicine, University Heart Center, Medical University of Graz, Graz, Austria. FAU - Tomasoni, Daniela AU - Tomasoni D AD - Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. FAU - Sverdlov, Aaron L AU - Sverdlov AL AD - College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia. aaron.sverdlov@newcastle.edu.au. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. aaron.sverdlov@newcastle.edu.au. AD - Cardiovascular Department, John Hunter Hospital, Newcastle, NSW, Australia. aaron.sverdlov@newcastle.edu.au. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20260704 PL - United States TA - Heart Fail Rev JT - Heart failure reviews JID - 9612481 RN - 0 (MYK-461) RN - 0 (Benzylamines) RN - 56HH86ZVCT (Uracil) SB - IM MH - Humans MH - Adolescent MH - *Cardiomyopathy, Hypertrophic/drug therapy/physiopathology MH - *Ventricular Outflow Obstruction, Left/drug therapy/physiopathology MH - Treatment Outcome MH - Benzylamines MH - Uracil/analogs & derivatives PMC - PMC13332878 OTO - NOTNLM OT - Adolescents OT - Hypertrophic obstructive cardiomyopathy OT - Mavacamten OT - SCOUT-HCM COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/05 00:03 MHDA- 2026/07/05 00:04 PMCR- 2026/07/04 CRDT- 2026/07/04 11:04 PHST- 2026/05/23 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/06/23 00:00 [revised] PHST- 2026/07/05 00:04 [medline] PHST- 2026/07/05 00:03 [pubmed] PHST- 2026/07/04 11:04 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - 10.1007/s10741-026-10655-x [pii] AID - 10655 [pii] AID - 10.1007/s10741-026-10655-x [doi] PST - epublish SO - Heart Fail Rev. 2026 Jul 4;31(1):78. doi: 10.1007/s10741-026-10655-x. PMID- 42400239 OWN - NLM STAT- MEDLINE DCOM- 20260704 LR - 20260817 IS - 1369-7625 (Electronic) IS - 1369-6513 (Print) IS - 1369-6513 (Linking) VI - 29 IP - 4 DP - 2026 Aug TI - Exploring the Acceptability of Integrating Dietitians Into Primary Care Dental Services for Children. PG - e70753 LID - 10.1111/hex.70753 [doi] LID - e70753 AB - BACKGROUND: Dental caries is a common childhood non-communicable disease strongly associated with high sugar intake. Beyond oral health, a poor diet can affect children's growth, development, and overall well-being. While dietary advice is central to preventive dental care, some primary care dental clinics have introduced body mass index (BMI) assessments and further dietary advice to address wider nutritional concerns in children. However, these efforts are often constrained by limited nutrition training, time constraints and concerns about sensitivity. Integrating dietitians into primary dental care may help overcome these barriers by enhancing dietary guidance, supporting broader nutritional needs and facilitating structured BMI assessments with appropriate follow-up. AIM: To explore the acceptability of integrating dietitians into primary dental care for children, guided by the theoretical framework of acceptability (TFA). METHODS: Dental professionals and caregivers were recruited from South West England, and dietitians from across the United Kingdom (April-December 2024). Semi-structured interviews were analysed inductively using reflexive thematic analysis. Findings were interpreted through the TFA to examine how emotional, ethical and structural factors shaped perceptions of acceptability. RESULTS: Semi-structured interviews were conducted with 23 participants: 10 dental professionals, 6 dietitians and 7 caregivers. Four inductive themes captured participants reasoning: (1) Balancing enthusiasm and sensitivity; (2) Negotiating the realities of integration; (3) Clarifying boundaries and expertise and (4) Building collective confidence. These themes aligned closely with the TFA, showing how emotional, ethical and structural factors interacted. Acceptability emerged as a dynamic balance of emotional and ethical alignment, practical feasibility, conceptual clarity and shared confidence. Perceived effectiveness was a unifying thread, with integration seen as acceptable when safeguards ensured emotional safety, ethical grounding and organisational support. CONCLUSION: Integrating dietitians was viewed as widely acceptable when collaboratively, sensitively and structurally delivered and supported. CI - (c) 2026 The Author(s). Health Expectations published by John Wiley & Sons Ltd. FAU - Hallewell, Lauren AU - Hallewell L AUID- ORCID: 0009-0004-6039-1274 AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Bescos, Raul AU - Bescos R AUID- ORCID: 0000-0002-3939-4743 AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Brookes, Zoe AU - Brookes Z AUID- ORCID: 0000-0002-8096-6256 AD - Peninsula Dental School, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Parkin, Tracey AU - Parkin T AUID- ORCID: 0000-0002-7081-2253 AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Witton, Robert AU - Witton R AUID- ORCID: 0000-0002-6424-4376 AD - Peninsula Dental School, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Casas-Agustench, Patricia AU - Casas-Agustench P AUID- ORCID: 0000-0003-4424-1087 AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. LA - eng PT - Journal Article PL - England TA - Health Expect JT - Health expectations : an international journal of public participation in health care and health policy JID - 9815926 SB - IM MH - Humans MH - *Nutritionists/psychology MH - *Primary Health Care/organization & administration MH - Child MH - Female MH - *Dental Care for Children/organization & administration MH - Male MH - Interviews as Topic MH - United Kingdom MH - Attitude of Health Personnel MH - Caregivers/psychology MH - Adult MH - England MH - Dentists/psychology PMC - PMC13332333 OTO - NOTNLM OT - children OT - dentistry OT - dietitian OT - interprofessional OT - nutrition COIS- The authors declare no conflicts of interest. Relevant professional affiliations include the British Dietetic Association, British Dental Association, College of Dietitians-Nutritionists of Catalonia and Member of the Association for Nutritionists. EDAT- 2026/07/04 16:11 MHDA- 2026/07/04 16:12 PMCR- 2026/07/03 CRDT- 2026/07/04 02:23 PHST- 2026/05/14 00:00 [revised] PHST- 2025/11/12 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/04 16:12 [medline] PHST- 2026/07/04 16:11 [pubmed] PHST- 2026/07/04 02:23 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - HEX70753 [pii] AID - 10.1111/hex.70753 [doi] PST - ppublish SO - Health Expect. 2026 Aug;29(4):e70753. doi: 10.1111/hex.70753. PMID- 42399850 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 3 TI - Formative research on a post-discharge monitoring program using SQ-LNS to reduce acute malnutrition relapse risk in Mali : a qualitative study. LID - 10.1186/s12889-026-28378-x [doi] LID - 2296 AB - INTRODUCTION: Up to 75% of children treated for severe acute malnutrition (SAM) relapse within six months of recovery, yet evidence on post-discharge interventions remains limited. We conducted a formative assessment to understand how small-quantity lipid-based nutrient supplements (SQ-LNS) could be integrated in post-discharge care to prevent relapse. OBJECTIVE: This study aimed to inform whether and how a program integrating SQ-LNS into post-discharge monitoring could be implemented in Mali. Specifically, we aimed to: 1) identify barriers and enablers to post-discharge monitoring, 2) develop one or more post-discharge models based on recommendations, 3) understand the feasibility of these model(s), 4) describe acceptability of the model(s) and product, and 5) propose a final model to be piloted at larger scale. METHODS: This formative study comprised two iterative phases conducted between September 2024 and May 2025. In exploratory Phase One, we conducted semi-structured interviews with 12 caregivers of children with SAM and eight treatment providers, in triangulation with 13 focus groups among caregivers, health care workers (HCW's), and supervisors. Themes included current practices, anticipated challenges, and service delivery preferences. Findings informed a confirmatory Phase Two involving four direct observations of three delivery models implemented at four sites and 13 interviews with similar participants. Textual data were coded and thematically analyzed using Dedoose software. RESULTS: Although national guidelines recommend routine post-discharge monitoring for SAM children, it was rarely practiced due to limited awareness among HCW's. Both caregivers and HCW's supported the idea of post-SAM monitoring, preferring on-site over home visits for feasibility. Caregivers valued growth monitoring, interacting with HCW's, and nutritional supplementation. While unfamiliar with SQ-LNS, caregivers viewed it positively based on their experience with therapeutic foods. Three delivery models were tested: (1) weekly visits for one month transitioning to fortnightly thereafter, (2) fortnightly visits and program days, and (3) fortnightly visits for caregivers and weekly program days at the health site. Model three proved most feasible for caregivers and providers. CONCLUSION: This formative research informed a program design that aligns with caregiver preferences and health system capacity, requiring minimal external support. Fortnightly post-discharge monitoring paired with SQ-LNS supplementation at treatment sites is recommended. CI - (c) 2026. The Author(s). FAU - Heymsfield, Grace AU - Heymsfield G AD - International Rescue Committee, New York, NY, USA. grace.heymsfield@rescue.org. FAU - Kangas, Suvi T AU - Kangas ST AD - International Rescue Committee, Brussels, Belgium. FAU - Cichon, Bernardette AU - Cichon B AD - International Rescue Committee, London, UK. FAU - Coulibaly, Issa Niamanto AU - Coulibaly IN AD - International Rescue Committee, Bamako, Mali. FAU - Diarra, Niele Hawa AU - Diarra NH AD - International Rescue Committee, Bamako, Mali. FAU - Diassana, Koniba AU - Diassana K AD - International Rescue Committee, Bamako, Mali. FAU - Haidara, Alhousseyni AU - Haidara A AD - International Rescue Committee, Bamako, Mali. FAU - Ouologuem, Bareye AU - Ouologuem B AD - Sub-division of Nutrition, Ministry of Health, Bamako, Mali. FAU - Diarra, Samba AU - Diarra S AD - University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. FAU - Kodish, Stephen AU - Kodish S AD - Penn State University, Penn State, University Park, PA, USA. LA - eng PT - Journal Article DEP - 20260703 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Lipids) SB - IM MH - Humans MH - Mali MH - Qualitative Research MH - *Severe Acute Malnutrition/prevention & control MH - Infant MH - Child, Preschool MH - *Patient Discharge MH - *Dietary Supplements MH - Recurrence MH - Focus Groups MH - Female MH - Male MH - *Lipids/administration & dosage MH - Interviews as Topic MH - Caregivers/psychology PMC - PMC13445792 OTO - NOTNLM OT - Acceptability OT - Feasibility OT - Formative research OT - Mali OT - Severe acute malnutrition (SAM) OT - Small-quantity lipid-based nutrient supplement (SQ-LNS) COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Institutional Review Board of the International Rescue Committee (H 1.00.080) and the Ethical Committee of the University of Sciences, Techniques and Technologies of Bamako (N.2024/211/USTTB). The study was conducted in accordance with the Declaration of Helsinki. Informed oral consent was obtained from participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/04 00:33 MHDA- 2026/08/07 06:35 PMCR- 2026/07/03 CRDT- 2026/07/03 23:56 PHST- 2025/12/01 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/08/07 06:35 [medline] PHST- 2026/07/04 00:33 [pubmed] PHST- 2026/07/03 23:56 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - 10.1186/s12889-026-28378-x [pii] AID - 28378 [pii] AID - 10.1186/s12889-026-28378-x [doi] PST - epublish SO - BMC Public Health. 2026 Jul 3;26(1):2296. doi: 10.1186/s12889-026-28378-x. PMID- 42399820 OWN - NLM STAT- MEDLINE DCOM- 20261004 LR - 20261007 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 4 TI - Nomogram for predicting 6-month BMIZ changes in children with Crohn's disease: a single-center retrospective study. LID - 10.1186/s12887-026-07258-8 [doi] LID - 936 AB - BACKGROUND: Perianal disease (PD) is an aggressive phenotype in children with Crohn's disease (CD), but its measurable impact on short-term nutritional recovery remains understudied. This study aimed to evaluate the independent effect of PD on the 6-month Body Mass Index Z-score (BMIZ) trajectory and to develop a practical nomogram for early risk stratification in pediatric CD. METHODS: A single-center retrospective cohort of 51 pediatric CD patients (29 with PD and 22 without PD) with at least 6 months of follow-up was enrolled from a tertiary hospital in Fujian, southern China, between July 2017 and March 2025. BMIZ trajectories over time were estimated using linear mixed models (LMM). Predictors of 6-month DeltaBMIZ were screened using univariate regression (P < 0.20), followed by LASSO regression (tenfold cross-validation) to construct a nomogram. Model performance was internally validated using 1000 bootstrap resamples (R(2), MAE, RMSE) and calibration plots. Decision curve analysis (DCA) was performed to evaluate clinical utility for predicting inadequate nutritional recovery (DeltaBMIZ 20) among the SWE parameters, TM thickness emerged as the strongest independent predictor of malnutrition (OR = 0.428, p < 0.001). ROC analyses demonstrated that TM thickness yielded the highest diagnostic accuracy (AUC = 0.887). A cut-off value of approximately 11.15 mm for this parameter provided a sensitivity of 82.9% and specificity of 90.7%. The DeLong test results confirmed that the discriminatory power of TM thickness was statistically superior to that of the elastography data. CONCLUSIONS: TM thickness measurement via B-mode ultrasound is a practical, reproducible, and promising adjunctive point-of-care parameter for detecting malnutrition-induced muscle atrophy in pediatric patients, demonstrating superiority over SWE parameters; however, external multicenter validation is warranted before routine clinical implementation. CI - (c) 2026 Wiley Periodicals LLC. FAU - Ayvaz, Huseyin AU - Ayvaz H AUID- ORCID: 0000-0003-0267-3295 AD - Department of Radiology, Division of Pediatric Radiology, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Tasolar, Sevgi Demiroz AU - Tasolar SD AUID- ORCID: 0000-0002-9836-6814 AD - Department of Radiology, Division of Pediatric Radiology, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Gok, Emre AU - Gok E AUID- ORCID: 0000-0001-9458-8076 AD - Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Gungor, Sukru AU - Gungor S AUID- ORCID: 0000-0002-0433-5970 AD - Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Varol, Fatma Ilknur AU - Varol FI AUID- ORCID: 0000-0001-5212-218X AD - Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Tasolar, Mehmet Hakan AU - Tasolar MH AUID- ORCID: 0000-0002-5657-7170 AD - Department of Cardiology, Inonu University Faculty of Medicine, Malatya, Turkey. LA - eng PT - Journal Article DEP - 20260703 PL - United States TA - J Clin Ultrasound JT - Journal of clinical ultrasound : JCU JID - 0401663 SB - IM OTO - NOTNLM OT - muscle atrophy OT - pediatric malnutrition OT - shear wave elastography OT - temporal muscle OT - ultrasonography EDAT- 2026/07/04 00:33 MHDA- 2026/07/04 00:33 CRDT- 2026/07/03 21:42 PHST- 2026/06/20 00:00 [revised] PHST- 2026/04/07 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/04 00:33 [medline] PHST- 2026/07/04 00:33 [pubmed] PHST- 2026/07/03 21:42 [entrez] AID - 10.1002/jcu.70320 [doi] PST - aheadofprint SO - J Clin Ultrasound. 2026 Jul 3. doi: 10.1002/jcu.70320. PMID- 42398892 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1953-8022 (Electronic) IS - 1246-7820 (Linking) VI - 33 IP - 4 DP - 2026 Nov TI - Albumin priming enables safe and effective red blood cell exchange in low-weight children with sickle cell disease. PG - 229-234 LID - S1246-7820(26)00099-6 [pii] LID - 10.1016/j.tracli.2026.06.011 [doi] AB - Red blood cell (RBC) exchanges (RCE) are particularly efficient to treat and prevent complications in patients with sickle cell anemia (SCA). However, the low-weight of young children is a barrier to their use. Spectra Optia is a therapeutic apheresis platform that enables automatic priming to prevent hemodynamic complications in low-weight children. The easiest method is to use albumin for priming, which is allowed by the software. We conducted a retrospective monocenter analysis of the feasibility, safety, and efficacy of albumin priming during RCE (RCE/Alb-primed) in 19 children weighing 12 to 23kg for a total of 153 sessions. They were treated either on an emergency basis (8 children, 8 sessions), before surgery (2 children, 4 sessions) or as part of a RCE program (9 children, 141 sessions). Indications of RCE/Alb-primed sessions included: (i) an extracorporeal volume of the kit equal to 15% of the child's total blood volume; (ii) a weight of less than 20kg; or (iii) a weight between 20 and 25kg with a hematocrit (Hct) of 20% or less. We monitored Grade 2 adverse events (AEs) during the sessions, in extenso decreased blood pressure, increased heart rate and fatigue. Post-apheresis hematocrit and the fraction of cell remaining (FCR) values after RCE were compared to the expected ones. A low incidence of complications was observed in the 153 RCE/Alb-primed sessions with only 1 episodes of transient Grade 2 AEs. Post-apheresis Hct and FCR reached expected values with the RCE/Alb-primed method. In conclusion, RCE/Alb-primed seems to be safe and efficient in young SCA children and should be proposed systematically for curative RCE or prophylactic programs. CI - Copyright (c) 2026 Societe francophone de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved. FAU - Hequet, O AU - Hequet O AD - Service d'Apherese, etablissement francais du sang Rhone Alpes, centre hospitalier Lyon Sud, Pierre-Benite, France; Inserm U1111, CIRI, Centre International for Infectiology Research, universite de Lyon, Lyon, France. Electronic address: olivier.hequet@efs.sante.fr. FAU - Revesz, D AU - Revesz D AD - Service d'Apherese, etablissement francais du sang Rhone Alpes, centre hospitalier Lyon Sud, Pierre-Benite, France. FAU - Chelghoum, Y AU - Chelghoum Y AD - Service d'Apherese, etablissement francais du sang Rhone Alpes, centre hospitalier Lyon Sud, Pierre-Benite, France. FAU - Kebaili, K AU - Kebaili K AD - Institut d'hematologie et d'oncologie pediatrique, hospices civils de Lyon, Lyon, France. FAU - Peugnet, A L AU - Peugnet AL AD - Institut d'hematologie et d'oncologie pediatrique, hospices civils de Lyon, Lyon, France; Laboratoire interuniversitaire de biologie de la motricite (LIBM) EA7424, equipe "Biologie vasculaire et du globule rouge", universite Claude-Bernard Lyon 1, Lyon, France. FAU - Villars, A AU - Villars A AD - Service immuno-hematologie et distribution, etablissement francais du sang Auvergne Rhone Alpes, centre hospitalier Edouard-Herriot, Lyon, France. FAU - Baud, C AU - Baud C AD - Service immuno-hematologie et distribution, etablissement francais du sang Auvergne Rhone Alpes, centre hospitalier Lyon Sud, Lyon, France. FAU - Cognasse, F AU - Cognasse F AD - Departement scientifique, etablissement francais du sang Auvergne-Rhone-Alpes, Saint-Etienne, France; Inserm U1059 SAINBIOSE, universite Jean-Monnet, mines Saint-Etienne, Saint-Etienne, France. FAU - Guironnet-Paquet, A AU - Guironnet-Paquet A AD - Service d'Apherese, etablissement francais du sang Rhone Alpes, centre hospitalier Lyon Sud, Pierre-Benite, France; Inserm U1111, CIRI, Centre International for Infectiology Research, universite de Lyon, Lyon, France. FAU - Halfon-Domenech, C AU - Halfon-Domenech C AD - Institut d'hematologie et d'oncologie pediatrique, hospices civils de Lyon, Lyon, France. FAU - Joly, P AU - Joly P AD - Laboratoire interuniversitaire de biologie de la motricite (LIBM) EA7424, equipe "Biologie vasculaire et du globule rouge", universite Claude-Bernard Lyon 1, Lyon, France; Laboratoire de biologie medicale multi-site. service de biochimie et biologie moleculaire, hospices civils de Lyon, Lyon, France; Laboratoire d'excellence sur le globule rouge (Labex GR-Ex), Paris, France. FAU - Connes, P AU - Connes P AD - Laboratoire interuniversitaire de biologie de la motricite (LIBM) EA7424, equipe "Biologie vasculaire et du globule rouge", universite Claude-Bernard Lyon 1, Lyon, France; Laboratoire d'excellence sur le globule rouge (Labex GR-Ex), Paris, France. LA - eng PT - Journal Article DEP - 20260703 PL - France TA - Transfus Clin Biol JT - Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine JID - 9423846 RN - 0 (Albumins) SB - IM MH - Humans MH - *Anemia, Sickle Cell/therapy/blood MH - Retrospective Studies MH - *Erythrocyte Transfusion/methods/adverse effects MH - Female MH - Male MH - Child, Preschool MH - Child MH - *Albumins/administration & dosage/therapeutic use MH - Hematocrit MH - Feasibility Studies MH - Body Weight MH - Adolescent MH - Blood Component Removal/methods OTO - NOTNLM OT - Priming OT - Red blood cell exchange OT - Sickle cell disease EDAT- 2026/07/04 00:33 MHDA- 2026/10/23 23:30 CRDT- 2026/07/03 19:39 PHST- 2026/05/05 00:00 [received] PHST- 2026/06/28 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/10/23 23:30 [medline] PHST- 2026/07/04 00:33 [pubmed] PHST- 2026/07/03 19:39 [entrez] AID - S1246-7820(26)00099-6 [pii] AID - 10.1016/j.tracli.2026.06.011 [doi] PST - ppublish SO - Transfus Clin Biol. 2026 Nov;33(4):229-234. doi: 10.1016/j.tracli.2026.06.011. Epub 2026 Jul 3. PMID- 42397854 OWN - NLM STAT- Publisher LR - 20260703 IS - 1476-8305 (Electronic) IS - 1028-415X (Linking) DP - 2026 Jul 3 TI - Integrated analysis of nutrition profiles and dried blood spot proteomics reveals patterns associated with autism spectrum disorder. PG - 1-16 LID - 10.1080/1028415X.2026.2684633 [doi] AB - OBJECTIVES: To investigate whether dietary behavior-derived nutritional profiles and proteomic analysis of dried blood spots (DBS) could identify patterns associated with autism spectrum disorder (ASD). METHODS: A total of 29 children with ASD (mean age, 56.0 +/- 8.7 months; 23 boys) and 27 control children (mean age, 60.6 +/- 9.5 months; 20 boys) participated in the study. Three-day food records were used to assess nutrient and food group intakes. Blood samples were collected as DBS. To evaluate group separation, partial least squares discriminant analysis was applied to food group data, nutrient intake, and proteomic data. Balanced accuracy (average of sensitivity and specificity) was estimated using 5-fold cross-validation (100 repeats). Candidate markers were selected based on variable importance in projection (VIP) scores, followed by pathway enrichment analysis of proteomic candidates. Tripartite relationships among candidate nutritional and proteomic markers and clinical measures (Childhood Autism Rating Scale; Aberrant Behavior Checklist; Social Responsiveness Scale; Full-Scale IQ; Vineland Adaptive Behavior Scales) were explored using correlation heatmaps. RESULTS: We prioritized 18 candidate nutritional markers and 10 proteomic markers. The proteins were significantly enriched in nervous system pathways. Correlation analyses revealed several tripartite relationships among nutritional markers, proteomic markers, and clinical measures, including an S100A6-(omega-6 intake or meat intake)-clinical measures relationship and an ALDH18A1-nuts/seeds intake-clinical measures relationship. DISCUSSION: Specific combinations of nutritional profiles and DBS-derived proteomic signatures were associated with symptom severity and functional outcomes in children with ASD. Dietary intake may help interpret these molecular and clinical patterns. Future studies are necessary to elucidate these interrelationships. FAU - Kwon, Hoshik AU - Kwon H AUID- ORCID: 0009-0001-0591-2696 AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Yoon, Su-In AU - Yoon SI AD - Department of Food and Nutrition, Chungnam National University, Daejeon, Republic of Korea. FAU - Baek, Sooyeon AU - Baek S AD - Department of Food and Nutrition, Chungnam National University, Daejeon, Republic of Korea. FAU - Hyun, Yerin AU - Hyun Y AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Kim, Ju Yeon AU - Kim JY AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Park, Dong Hui AU - Park DH AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Yu, Jiyoung AU - Yu J AD - Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Cho, Jin Ah AU - Cho JA AD - Department of Food and Nutrition, Chungnam National University, Daejeon, Republic of Korea. AD - Glocal Life Care Convergence Program, Interdisciplinary Education Center for the Innovative Next Generation Leaders in Glocal Lifecare, Chungnam National University, Daejeon, Republic of Korea. FAU - Kim, Hyo-Won AU - Kim HW AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Kim, Kyunggon AU - Kim K AD - Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. AD - Department of Medical Informatics and Statistics, Brain Korea 21 plus, University of Ulsan College of Medicine, Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20260703 PL - England TA - Nutr Neurosci JT - Nutritional neuroscience JID - 100892202 SB - IM OTO - NOTNLM OT - Autism spectrum disorder OT - nutrition OT - proteomics EDAT- 2026/07/03 18:34 MHDA- 2026/07/03 18:34 CRDT- 2026/07/03 13:42 PHST- 2026/07/03 18:34 [medline] PHST- 2026/07/03 18:34 [pubmed] PHST- 2026/07/03 13:42 [entrez] AID - 10.1080/1028415X.2026.2684633 [doi] PST - aheadofprint SO - Nutr Neurosci. 2026 Jul 3:1-16. doi: 10.1080/1028415X.2026.2684633. PMID- 42397661 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jul 3 TI - An interactive web-based tool for computing BMI standard deviation scores in Italian children and adolescents using national growth references. LID - 10.1007/s40519-026-01887-9 [doi] LID - 86 AB - BACKGROUND: Body mass index (BMI) standard deviation scores (SDS) are essential for age- and sex-adjusted assessments in pediatric populations, including growth trajectories. Their accuracy depends on the use of population-specific reference data, as BMI distributions vary substantially across countries. Despite the availability of internationally recognized growth standards, no accessible computational tool tailored to Italian normative data has been previously described. OBJECTIVES: This paper describes the development and validation of an interactive, freely accessible web-based calculator for deriving BMI-SDS in Italian children and adolescents, based on the nationally representative Cacciari et al. (2006) growth reference dataset. METHODS: BMI-SDS computation is based on the LMS parameterization of Italian reference curves, which provide sex-specific L (skewness), M (median), and S (coefficient of variation) values at half-year age intervals from 2 to 20 years for a nationally representative Italian sample of approximately 70,000 children and adolescents. RESULTS: The tool was implemented in R using the Shiny web application framework and is hosted at https://turius.shinyapps.io/BMI_SDS_IT/ . Given user-entered weight, height, age, and sex, the tool computes BMI (kg/m(2)), derives the corresponding BMI-SDS and returns i) age- and sex-adjusted BMI-SDS; ii) the corresponding percentile; iii) a graphical representation of the individual's position on the reference distribution. CONCLUSIONS: The tool offers a straightforward, clinician- and researcher-friendly interface for computing age- and sex-standardized BMI scores using Italian-specific references, supporting more accurate weight-status classification in both clinical practice and epidemiological research. CI - (c) 2026. The Author(s). FAU - Tarchi, Livio AU - Tarchi L AUID- ORCID: 0000-0002-9931-5621 AD - Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini, 6, Florence, FI, Italy. livio.tarchi@unifi.it. AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. livio.tarchi@unifi.it. AD - University Hospital of Florence, Florence, FI, Italy. livio.tarchi@unifi.it. FAU - Mattesini, Elena AU - Mattesini E AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. FAU - Dani, Cristiano AU - Dani C AD - Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini, 6, Florence, FI, Italy. AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. FAU - D'Areglia, Eleonora AU - D'Areglia E AD - University Hospital of Florence, Florence, FI, Italy. FAU - Castellini, Giovanni AU - Castellini G AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. AD - University Hospital of Florence, Florence, FI, Italy. FAU - Ricca, Valdo AU - Ricca V AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. AD - University Hospital of Florence, Florence, FI, Italy. LA - eng GR - PE0000006/Ministero dell'Universita e della Ricerca/ PT - Journal Article DEP - 20260703 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Adolescent MH - *Body Mass Index MH - Child MH - Female MH - Italy MH - Male MH - Internet MH - Reference Values MH - Child, Preschool MH - Young Adult MH - Growth Charts MH - Body Weight/physiology MH - Software PMC - PMC13658362 OTO - NOTNLM OT - Anorexia OT - BMI z-score OT - Growth curve OT - Obesity OT - Overweight OT - Underweight OT - Weight COIS- Declarations. Ethics approval and consent to participate: Not applicable. The project does not involve testing on human subjects, user studies, or gathering data from users. The software analyzes or utilizes data that are already in the public domain and fully anonymized. The project does not process personally identifiable information or sensitive data. The software is not a diagnostic tool or part of a clinical trial. Competing interests: The authors declare no competing interests. EDAT- 2026/07/03 12:32 MHDA- 2026/10/13 05:31 PMCR- 2026/07/03 CRDT- 2026/07/03 11:16 PHST- 2026/03/20 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/10/13 05:31 [medline] PHST- 2026/07/03 12:32 [pubmed] PHST- 2026/07/03 11:16 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - 10.1007/s40519-026-01887-9 [pii] AID - 1887 [pii] AID - 10.1007/s40519-026-01887-9 [doi] PST - epublish SO - Eat Weight Disord. 2026 Jul 3;31(1):86. doi: 10.1007/s40519-026-01887-9. PMID- 42397038 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20260930 IS - 1440-1754 (Electronic) IS - 1034-4810 (Print) IS - 1034-4810 (Linking) VI - 62 IP - 9 DP - 2026 Sep TI - Impact of Access to Pasteurised Donor Human Milk on Rates of Necrotising Enterocolitis in Neonatal Units in Australia: A Cohort Study. PG - 1611-1620 LID - 10.1111/jpc.70472 [doi] AB - BACKGROUND AND AIM: In 2018, a pasteurised donor human milk (PDHM) service was established within Australia's national blood service, Lifeblood, and subsequently expanded to a national service. Before 2018, five milk banks operated in Australia, but most infants admitted to Australian neonatal intensive care units (NICUs) still did not have access to PDHM. This study aimed to compare infant outcomes before and after Australian NICUs had access to an assured supply of PDHM from Lifeblood. METHODS: Cohort study utilising Australian and New Zealand Neonatal Network data for infants born < 32 weeks' gestation admitted to 15 NICUs across Australia over a 3-year period (2018-2020; n = 4395 infants). The primary study factor was NICU access to an assured supply of PDHM from Lifeblood. Neonatal outcomes were compared in periods with "PDHM available" versus "PDHM not available". The primary outcome was the proportion of infants born < 28 weeks' gestation who developed NEC. Secondary outcomes included duration of parenteral nutrition, retinopathy of prematurity, infection, death, length of stay, weight at discharge, and breast milk feeding at discharge. RESULTS: After adjusting for confounding risks, NEC relative risk was 38% lower for infants born < 28 weeks' (aRR 0.62, 95% CI 0.46-0.83) when Lifeblood PDHM was available. Weight at discharge (2828.8 vs. 2939.56 g, p = 0.001) was lower when PDHM was available. Breast milk feeding at discharge, infections and death were not associated with PDHM availability. CONCLUSIONS: Reliable access to PDHM was associated with reduced risk of NEC for infants born < 28 weeks' gestation in Australian NICUs. CI - (c) 2026 The Author(s). Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Klein, Laura D AU - Klein LD AUID- ORCID: 0000-0002-7287-8029 AD - Australian Red Cross Lifeblood, Melbourne, Australia. FAU - Lui, Kei AU - Lui K AD - Division of Newborn Services, Royal Hospital for Women, Sydney, Australia. AD - School of Population Health, University of New South Wales, Sydney, Australia. FAU - Chughtai, Abrar A AU - Chughtai AA AD - School of Population Health, University of New South Wales, Sydney, Australia. FAU - Osborn, David A AU - Osborn DA AUID- ORCID: 0000-0001-7514-7400 AD - RPA Newborn Care, Royal Prince Alfred Hospital, Camperdown, Australia. FAU - Guaran, Robert AU - Guaran R AD - Liverpool Hospital, Liverpool, Australia. FAU - McPhee, Andrew J AU - McPhee AJ AD - Department of Neonatal Medicine, Women's and Children's Hospital, Adelaide, Australia. FAU - Brandenberg, Ulrike AU - Brandenberg U AD - Neonatal Intensive Care Unit, Nepean Hospital, Penrith, New South Wales, Australia. FAU - Callander, Ian AU - Callander I AD - Liverpool Hospital, Liverpool, Australia. FAU - Amir, Lisa H AU - Amir LH AUID- ORCID: 0000-0002-2510-1399 AD - Judith Lumley Centre, School of Nursing and Midwifery, La Trobe University, Melbourne, Australia. AD - Breastfeeding Service, Royal Women's Hospital, Parkville, Australia. FAU - Sulfaro, Christine AU - Sulfaro C AD - Australian Red Cross Lifeblood, Melbourne, Australia. FAU - Brown, Richard AU - Brown R AD - Australian Red Cross Lifeblood, Melbourne, Australia. FAU - Irving, David O AU - Irving DO AUID- ORCID: 0000-0003-2434-0686 AD - Australian Red Cross Lifeblood, Melbourne, Australia. AD - Faculty of Health, University of Technology, Sydney, Australia. FAU - Hoad, Veronica AU - Hoad V AUID- ORCID: 0000-0002-7827-3661 AD - Australian Red Cross Lifeblood, Melbourne, Australia. FAU - Pink, Joanne AU - Pink J AD - Australian Red Cross Lifeblood, Melbourne, Australia. FAU - Clifford, Vanessa AU - Clifford V AD - Australian Red Cross Lifeblood, Melbourne, Australia. AD - Department of Paediatrics, University of Melbourne, Melbourne, Australia. CN - Australian and New Zealand Neonatal Network LA - eng GR - Baxter International Foundation/ GR - 4-EML85BJ/Department of Health and Aged Care, Australian Government/ PT - Journal Article DEP - 20260703 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Infant, Newborn MH - Australia/epidemiology MH - *Milk, Human MH - *Intensive Care Units, Neonatal MH - *Enterocolitis, Necrotizing/epidemiology/prevention & control MH - Female MH - *Milk Banks MH - Cohort Studies MH - Male MH - *Pasteurization MH - Infant, Premature MH - New Zealand PMC - PMC13617227 COIS- Laura D. Klein, Christine Sulfaro, Richard Brown, David O. Irving, Veronica Hoad, Joanne Pink, and Vanessa Clifford are employees of Australian Red Cross Lifeblood, which supplies pasteurised donor human milk to hospitals in Australia. Lifeblood is a not-for-profit organisation that only accepts donations from voluntary, non-remunerated donors. Robert Guaran is Chair of the Pasteurised Donor Human Milk Clinical Advisory Committee, as a component of his role as a Senior Clinical Advisor-Neonatology in the NSW Ministry of Health. Robert Guaran is also an unpaid member of the Miracle Babies Foundation Board and Lifeblood Milk Clinical Advisory Board. In the past 3 years, Andrew J. McPhee has received research grant support from Fonterra and travel and conference support from Clover Corp to present a paper at a sponsored session. Ulrike Brandenberg is an unpaid member of the Lifeblood Milk Clinical Advisory Board. The authors declare no conflicts of interest. FIR - Morris, Scott IR - Morris S FIR - Schmidt, Peter IR - Schmidt P FIR - Chauhan, Manbir IR - Chauhan M FIR - Korostenski, Larissa IR - Korostenski L FIR - Sharp, Mary IR - Sharp M FIR - Resnick, Steven IR - Resnick S FIR - Thomas, Rebecca IR - Thomas R FIR - Strunk, Tobias IR - Strunk T FIR - Stack, Jacqueline IR - Stack J FIR - Birch, Pita IR - Birch P FIR - Oliver, Tori IR - Oliver T FIR - Casalaz, Dan IR - Casalaz D FIR - Holberton, Jim IR - Holberton J FIR - Stewart, Alice IR - Stewart A FIR - Hunt, Rod IR - Hunt R FIR - Tan, Kenneth IR - Tan K FIR - Cooke, Lucy IR - Cooke L FIR - Downe, Lyn IR - Downe L FIR - Davis, Jonathan IR - Davis J FIR - Stewart, Michael IR - Stewart M FIR - Berry, Andrew IR - Berry A FIR - Hickey, Leah IR - Hickey L FIR - Kgosiemang, Mantho IR - Kgosiemang M FIR - De Paoli, Tony IR - De Paoli T FIR - Spotswood, Naomi IR - Spotswood N FIR - Bolisetty, Srinivas IR - Bolisetty S FIR - Lui, Kei IR - Lui K FIR - Staub, Eveline IR - Staub E FIR - Greenhalgh, Mark IR - Greenhalgh M FIR - Koorts, Pieter IR - Koorts P FIR - Jacobs, Sue IR - Jacobs S FIR - Keir, Amy IR - Keir A FIR - Collins, Clare IR - Collins C FIR - Numa, Andrew IR - Numa A FIR - Carlisle, Hazel IR - Carlisle H FIR - Badawi, Nadia IR - Badawi N FIR - Popat, Himanshu IR - Popat H FIR - Alcock, Gary IR - Alcock G FIR - Luig, Melissa IR - Luig M FIR - Kent, Alison IR - Kent A FIR - Dixon, Bronwyn IR - Dixon B FIR - Darlow, Brian IR - Darlow B FIR - Fowlie, Peter IR - Fowlie P FIR - Kelly, Andrew IR - Kelly A FIR - Bloomfield, Guy IR - Bloomfield G FIR - Buksh, Mariam IR - Buksh M FIR - Battin, Malcolm IR - Battin M FIR - van den Boom, Jutta IR - van den Boom J FIR - Miller, Helen IR - Miller H FIR - Allermo-Fletcher, Angelica IR - Allermo-Fletcher A FIR - Jacobs, Claire IR - Jacobs C FIR - Rajadurai, Victor Samuel IR - Rajadurai VS FIR - Lam, Simon IR - Lam S FIR - Chambers, Georgina IR - Chambers G FIR - Barker, David IR - Barker D FIR - Dhawan, Anjali IR - Dhawan A FIR - Merida, Natalie IR - Merida N FIR - Harrison, Denise IR - Harrison D FIR - Tan, Kenneth IR - Tan K FIR - Austin, Nicola IR - Austin N FIR - Bajuk, Barbara IR - Bajuk B FIR - Jardine, Luke IR - Jardine L FIR - Meyer, Michael IR - Meyer M FIR - Schindler, Tim IR - Schindler T FIR - Stark, Michael IR - Stark M FIR - Strunk, Tobias IR - Strunk T FIR - Travadi, Javeed IR - Travadi J EDAT- 2026/07/03 16:10 MHDA- 2026/09/28 05:33 PMCR- 2026/09/28 CRDT- 2026/07/03 08:24 PHST- 2026/04/16 00:00 [revised] PHST- 2025/12/23 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/09/28 05:33 [medline] PHST- 2026/07/03 16:10 [pubmed] PHST- 2026/07/03 08:24 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - JPC70472 [pii] AID - 10.1111/jpc.70472 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Sep;62(9):1611-1620. doi: 10.1111/jpc.70472. Epub 2026 Jul 3. PMID- 42396673 OWN - NLM STAT- Publisher LR - 20260717 IS - 1475-2719 (Electronic) IS - 0029-6651 (Linking) DP - 2026 Jul 3 TI - Using positive social influences to increase children's vegetable intake. PG - 1-9 LID - 10.1017/S0029665126105060 [doi] AB - Despite the established health benefits of vegetables, most children do not consume enough to meet dietary recommendations. Early childhood is a critical period for shaping lifelong eating habits, and social eating experiences play an important role in this learning. This review synthesises evidence on how positive social influences support children's vegetable intake. Findings across shared eating occasions, positive eating atmosphere, modelling and social facilitation demonstrate that social experiences shape healthy dietary behaviour, including vegetable intake. The review also highlights the importance of individual differences, including children's eating behaviours and household characteristics such as socioeconomic status, food insecurity and household chaos, which may influence both the feasibility and effectiveness of creating positive social eating environments. In addition, the review identifies key opportunities for intervention and emphasises the need for more longitudinal research to understand how social eating processes evolve across development. Together, the evidence underscores the potential of positive social influences to enhance children's vegetable consumption and supports the development of tailored, socially grounded nutrition interventions. FAU - Edwards, Katie L AU - Edwards KL AUID- ORCID: 0000-0003-1076-8382 AD - School of Psychology, https://ror.org/03angcq70University of Birmingham, UK. FAU - Higgs, Suzanne AU - Higgs S AD - School of Psychology, https://ror.org/03angcq70University of Birmingham, UK. LA - eng PT - Journal Article PT - Review DEP - 20260703 PL - England TA - Proc Nutr Soc JT - The Proceedings of the Nutrition Society JID - 7505881 SB - IM OTO - NOTNLM OT - Children's eating OT - Eating atmosphere OT - Modelling OT - Social influences OT - Vegetable intake EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:31 CRDT- 2026/07/03 05:52 PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 06:31 [medline] PHST- 2026/07/03 05:52 [entrez] AID - S0029665126105060 [pii] AID - 10.1017/S0029665126105060 [doi] PST - aheadofprint SO - Proc Nutr Soc. 2026 Jul 3:1-9. doi: 10.1017/S0029665126105060. PMID- 42396614 OWN - NLM STAT- Publisher LR - 20260703 IS - 1365-2516 (Electronic) IS - 1351-8216 (Linking) DP - 2026 Jul 3 TI - Physical Activity and Sedentary Behaviour in Children With Haemophilia. LID - 10.1111/hae.70347 [doi] AB - INTRODUCTION: Physical activity (PA) is vital in child development, while inactivity remains a leading contributor to global mortality. Therapeutic advances have enabled greater PA in boys with haemophilia (BwH), yet robust UK data on objectively measured PA and sedentary behaviour (SB) across severities are limited. AIM: To investigate PA and SB in BwH and assess adherence to World Health Organization (WHO) guidelines for moderate-to-vigorous physical activity (MVPA). METHODS: Sub-analysis of a prospective cohort at a UK haemophilia centre (2018). Participants (n = 36; 6-16 years; all severities including inhibitors) wore hip mounted ActiGraph GT3X accelerometers for 7 days. Valid data required >/= 9 h/day for >/= 4 days. MVPA and SB were analysed using Evenson thresholds. Mixed-effects models with random intercepts examined demographic/clinical correlates of MVPA and SB and the odds of achieving >60 min/day of MVPA. RESULTS: Across 216 valid days median daily MVPA was 52.5 min/day (IQR: 30.9-80.2), with no significant differences by disease severity. Age was the only significant predictor of MVPA and SB: each additional year was associated with 7.6 fewer minutes of MVPA and 27.6 more minutes of SB per day (p < 0.01). Only 39.8% of valid days met the WHO MVPA guidelines. The probability of meeting this target declined from 79% at age 6to 8% at age 14. CONCLUSIONS: Most BwH did not meet WHO MVPA guidelines, though activity levels were encouraging. Age-related declines in MVPA and increases in SB mirror those seen in the general population, underscoring the need for early, tailored interventions to support lifelong activity in haemophilia. CI - (c) 2026 The Author(s). Haemophilia published by John Wiley & Sons Ltd. FAU - Bladen, Melanie AU - Bladen M AUID- ORCID: 0000-0002-7413-1906 AD - Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. AD - Physiotherapy, UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Alderson, Lucy AU - Alderson L AD - Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. FAU - Main, Eleanor AU - Main E AD - Physiotherapy, UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Cortina-Borja, Mario AU - Cortina-Borja M AD - Population, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK. LA - eng GR - 206936/Sir William Coxen Trust Fund/ PT - Journal Article DEP - 20260703 PL - England TA - Haemophilia JT - Haemophilia : the official journal of the World Federation of Hemophilia JID - 9442916 SB - IM OTO - NOTNLM OT - accelerometer OT - children OT - haemophilia OT - physical activity OT - sedentary behaviours EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:31 CRDT- 2026/07/03 05:34 PHST- 2026/01/28 00:00 [revised] PHST- 2025/09/04 00:00 [received] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/07/03 06:31 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:34 [entrez] AID - 10.1111/hae.70347 [doi] PST - aheadofprint SO - Haemophilia. 2026 Jul 3. doi: 10.1111/hae.70347. PMID- 42396129 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260703 LR - 20260813 IS - 3050-2225 (Electronic) IS - 3050-2225 (Linking) VI - 13 DP - 2026 Jan-Dec TI - Implementation of Child Life Services in Pediatric HSCT: A Pilot Study From Thailand. PG - 30502225261466108 LID - 10.1177/30502225261466108 [doi] LID - 30502225261466108 AB - BACKGROUND: Despite improved survival after pediatric hematopoietic stem cell transplantation (HSCT) in Thailand, many children experience physical and psychological distress. This pilot study evaluated the feasibility of a child life program and its preliminary effects on outcomes. METHODS: This pilot pre-post study included 10 children aged 2-8 years undergoing HSCT. The program comprised an HSCT educational video, therapeutic play, art therapy, online group activities, and homebound instruction after discharge. Outcomes were assessed at baseline and 6 months using the Pediatric Quality of Life Inventory (PedsQL), Child Behavior Checklist (CBCL), and Parenting Stress Index (PSI). Changes were analyzed using paired t-tests. RESULTS: PedsQL total, nausea, and nutrition scores improved significantly. PSI difficult child scores decreased slightly, whereas CBCL scores showed no significant changes. Six children returned to school within one year. CONCLUSION: Child life services were feasible and showed potential to improve short-term quality of life in HSCT patients. CI - (c) The Author(s) 2026. FAU - Yooyen, Keerati AU - Yooyen K AD - Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. RINGGOLD: 26687 FAU - Chuchottaworn, Kanokphan AU - Chuchottaworn K AD - Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. RINGGOLD: 26687 FAU - Pakakasama, Samart AU - Pakakasama S AD - Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. RINGGOLD: 26687 FAU - Chuthapisith, Jariya AU - Chuthapisith J AUID- ORCID: 0000-0001-7571-919X AD - Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. RINGGOLD: 26687 LA - eng PT - Journal Article DEP - 20260701 PL - United States TA - Sage Open Pediatr JT - Sage open pediatrics JID - 9919052035406676 PMC - PMC13323666 OTO - NOTNLM OT - HSCT OT - child life services OT - pediatric oncology OT - psychosocial intervention COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/03 10:11 MHDA- 2026/07/03 10:12 PMCR- 2026/07/01 CRDT- 2026/07/03 05:28 PHST- 2026/03/12 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/03 10:12 [medline] PHST- 2026/07/03 10:11 [pubmed] PHST- 2026/07/03 05:28 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.1177_30502225261466108 [pii] AID - 10.1177/30502225261466108 [doi] PST - epublish SO - Sage Open Pediatr. 2026 Jul 1;13:30502225261466108. doi: 10.1177/30502225261466108. eCollection 2026 Jan-Dec. PMID- 42395617 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260703 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Establishment of a CT-based prediction model for endotracheal tube size in infants aged <1 year. PG - 1796799 LID - 10.3389/fped.2026.1796799 [doi] LID - 1796799 AB - OBJECTIVE: By quantifying airway parameters on computed tomography (CT) and incorporating clinical factors such as age and prematurity, this study developed an airway prediction model for infants to provide more accurate guidance for endotracheal tube size selection and insertion depth in patients under one year of age. METHODS: A retrospective analysis of data on infants under one year of age who underwent preoperative anesthesia evaluation at Peking University People's Hospital from January 2020 to December 2022. Inclusion criteria: All enrolled infants underwent chest CT examination, with the scanning range covering the level of the cricoid cartilage. The development of cricoid cartilage was associated with laryngeal cartilage maturity. Its size and ossification degree change with age, sex, height and other factors. Therefore, we collected clinical data including the age, sex, gestational age, preterm birth, height and weight at birth and visit which may affect the shortest diameter of the cricoid cartilage in children. Infants with congenital laryngeal malformations, acquired nutritional deficiencies, hormonal abnormalities such as hypothyroidism, neck tumors and a history of maternal smoking during pregnancy were excluded. Accurately measure the shortest inner diameter of the cricoid cartilage and the distance from the cricoid cartilage to the carina on CT images. SPSS 24.0 software was used for simple and multiple linear regression analysis to screen key factors. Corresponding prediction models were established for the shortest cricoid cartilage diameter and the cricoid-to-carina distance, so as to facilitate the individualized selection of tracheal tube sizes and insertion depths in clinical practice. RESULTS: In this study, age and preterm birth were identified as independent influencing factors for the shortest cricoid cartilage diameter in infants [P = 0.008, 0.005(95% CI: 0.001 to 0.008); P = 0.022, -1.261 (95% CI: -2.321 to -0.201)]. The established prediction formulas were as follows: the shortest diameter of the cricoid cartilage in full-term infants (mm) = 6.119 + 0.005 x age; The shortest diameter of the cricoid cartilage in preterm infants (mm) = 6.119 + 0.005 x age-1.261. For the distance from the cricoid cartilage to the carina, age was the only significant influencing factor [P = 0.003, 35.725(95% CI: 0.016 to 0.073)], and carina formula was derived as follows: distance from the cricoid cartilage to the carina (mm) = 35.725 + 0.044 x age. CONCLUSION: Age and preterm status were independently associated with the shortest cricoid cartilage diameter in infants under one year of age, suggesting that preterm infants may require smaller endotracheal tubes than full-term infants of the same age. Age was also associated with the cricoid-to-carina distance. These CT-based findings may support more individualized airway management in infants. However, despite internal bootstrap validation, the model remains limited by the lack of external validation, small sample size, and highly specific ophthalmologic surgical population; therefore, broader validation is required before clinical generalization. CI - (c) 2026 Li, Sun, Wu and Tian. FAU - Li, Yan AU - Li Y AD - Department of Anesthesiology, Peking University People's Hospital, Beijing, China. FAU - Sun, Chao AU - Sun C AD - Department of Radiology, Peking University People's Hospital, Beijing, China. AD - Department of Medical Information Center, Peking University People's Hospital, Beijing, China. FAU - Wu, Yanqiu AU - Wu Y AD - Department of Medical Information Center, Peking University People's Hospital, Beijing, China. FAU - Tian, Xue AU - Tian X AD - Department of Anesthesiology, Peking University People's Hospital, Beijing, China. LA - eng PT - Journal Article DEP - 20260618 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13323497 OTO - NOTNLM OT - chest CT OT - cricoid cartilage OT - infants OT - preterm infants OT - tracheal intubation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:32 PMCR- 2026/06/18 CRDT- 2026/07/03 05:25 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/03 00:00 [revised] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/07/03 06:32 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:25 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.3389/fped.2026.1796799 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 18;14:1796799. doi: 10.3389/fped.2026.1796799. eCollection 2026. PMID- 42395293 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Mediating role of exercise behavioral intention in the relationship between exercise self-efficacy and physical activity levels in vocational education students. PG - 1833167 LID - 10.3389/fpubh.2026.1833167 [doi] LID - 1833167 AB - BACKGROUND: Social Cognitive Theory and the Theory of Planned Behavior suggest that self-efficacy influences physical activity through behavioral intention; however, evidence in vocational students is scarce. OBJECTIVE: This study examined whether exercise behavioral intention mediates the association between exercise self-efficacy and physical activity levels among vocational education students in Shanghai. METHODS: A cross sectional survey was conducted with 992 students from four vocational colleges. Participants completed validated measures of exercise self-efficacy (nine items, 1-10 scale), exercise behavioral intention (five items, 5-point Likert scale), and physical activity (IPAQ-SF). Data were analyzed using SPSS 25.0 (IBM Corporation, Armonk, New York, USA) and AMOS 26.0 (IBM Corporation, Armonk, New York, USA), adjusting for gender, age, and education level. RESULTS: Exercise self-efficacy was positively associated with exercise behavioral intention (r = 0.612, p < 0.001) and physical activity (r = 0.322, p < 0.001). Mediation analysis showed that behavioral intention partially mediated this relationship (indirect effect = 0.122, 95% CI [0.085, 0.163]), accounting for 45.19% of the total effect. CONCLUSION: Exercise self-efficacy is associated with physical activity both directly and indirectly via behavioral intention in vocational students. Interventions enhancing self-efficacy and behavioral intention may support higher activity levels, though longitudinal studies are needed to confirm directionality. CI - Copyright (c) 2026 Jing, Zhai, Xu, Wu and Wang. FAU - Jing, Ziyang AU - Jing Z AD - Shanghai Technician School, Shanghai University of Engineering Science, Shanghai, China. FAU - Zhai, Rongxuan AU - Zhai R AD - Department of Sports Medicine, Sport and Health Research Center, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Physical Education Department, Tongji University, Shanghai, China. FAU - Xu, Zihan AU - Xu Z AD - School of Public Administration, Hangzhou Normal University, Hangzhou, China. FAU - Wu, Xudong AU - Wu X AD - Shanghai Technician School, Shanghai University of Engineering Science, Shanghai, China. FAU - Wang, Lejun AU - Wang L AD - Department of Sports Medicine, Sport and Health Research Center, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Physical Education Department, Tongji University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260618 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Self Efficacy MH - *Intention MH - Female MH - *Exercise/psychology MH - Male MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - *Vocational Education MH - China MH - Young Adult MH - Surveys and Questionnaires MH - Adult MH - Theory of Planned Behavior MH - Adolescent PMC - PMC13323127 OTO - NOTNLM OT - exercise behavioral intention OT - exercise self-efficacy OT - mediating effect OT - physical activity OT - vocational education students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 16:10 PMCR- 2026/06/18 CRDT- 2026/07/03 05:20 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/07/03 16:10 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:20 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1833167 [doi] PST - epublish SO - Front Public Health. 2026 Jun 18;14:1833167. doi: 10.3389/fpubh.2026.1833167. eCollection 2026. PMID- 42395143 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260703 LR - 20260813 IS - 2475-0328 (Electronic) IS - 2475-0328 (Linking) VI - 10 IP - 4 DP - 2026 Jul TI - Preoperative Total Iron-Binding Capacity Is a Novel Surrogate Marker of Short- and Long-Term Outcomes After Liver Resection for Hepatocellular Carcinoma. PG - 1280-1288 LID - 10.1002/ags3.70206 [doi] AB - BACKGROUND: This study aimed to examine whether preoperative serum total iron-binding capacity (TIBC), which is directly proportional to transferrin level, correlates with short- and long-term outcomes after hepatectomy. METHODS: Preoperative TIBC levels, calculated by summing serum iron and unsaturated iron binding capacity, were evaluated in 577 patients who underwent hepatectomy for hepatocellular carcinoma. We defined TIBC < 274 mug/dL calculated by receiver-operating characteristic (ROC) analysis as low TIBC. We evaluated the relationship between preoperative TIBC levels and short- and long-term outcomes after hepatectomy. RESULTS: Low preoperative TIBC levels were correlated with lower body mass index, worse Child Pugh score, lower albumin, higher CRP, lower hemoglobin, lower serum iron, higher controlling nutritional status (CONUT) score, lower prognostic nutritional index (PNI), and larger tumor size compared to those in high TIBC levels (p = 0.0070, 0.0098, < 0.0001, 0.0008, 0.0086, 0.0018, 0.0008, < 0.0001, and 0.016, respectively). Patients with low preoperative TIBC levels experienced significantly more frequent postoperative complications of Clavien-Dindo classification (CDc) >/= II and III in univariate and multivariate analyses (CDc>/=II; hazard ratio [HR] 1.69, 95% confidence interval [CI] 1.010-2.799, p = 0.046/CDc>/=III; hazard ratio [HR] 1.92, 95% confidence interval [CI] 1.015-3.506, p = 0.045). Furthermore, these patients were significantly correlated with worse overall survival (OS) and relapse free survival (RFS) in univariate and multivariate analyses (OS; HR 3.24, 95% CI 1.783-5.805, p = 0.0002/RFS; HR 1.65, 95% CI 1.009-2.720, p = 0.046). CONCLUSION: Preoperative serum TIBC levels may be a novel surrogate marker of postoperative complications and long-term survival after hepatectomy. CI - (c) 2026 The Author(s). Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery. FAU - Yamane, Taishi AU - Yamane T AUID- ORCID: 0009-0001-1000-7738 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Hayashi, Hiromitsu AU - Hayashi H AUID- ORCID: 0000-0002-1832-4287 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Ogawa, Daisuke AU - Ogawa D AUID- ORCID: 0000-0001-5500-7996 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Kinoshita, Shotaro AU - Kinoshita S AUID- ORCID: 0000-0002-6690-4702 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Shiraishi, Yuta AU - Shiraishi Y AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Yamao, Takanobu AU - Yamao T AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Kitano, Yuki AU - Kitano Y AUID- ORCID: 0000-0001-6292-8670 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Miyata, Tatsunori AU - Miyata T AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Okabe, Hirohisa AU - Okabe H AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Iwatsuki, Masaaki AU - Iwatsuki M AUID- ORCID: 0000-0002-0886-4618 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. LA - eng PT - Journal Article DEP - 20260225 PL - Japan TA - Ann Gastroenterol Surg JT - Annals of gastroenterological surgery JID - 101718062 PMC - PMC13326819 OTO - NOTNLM OT - hepatocellular carcinoma OT - prognostic marker OT - total iron-binding capacity COIS- Masaaki Iwatsuki is an editorial member of Annals of Gastroenterological Surgery. EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:32 PMCR- 2026/02/25 CRDT- 2026/07/03 05:19 PHST- 2025/11/30 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/02/15 00:00 [accepted] PHST- 2026/07/03 06:32 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:19 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - AGS370206 [pii] AID - 10.1002/ags3.70206 [doi] PST - epublish SO - Ann Gastroenterol Surg. 2026 Feb 25;10(4):1280-1288. doi: 10.1002/ags3.70206. eCollection 2026 Jul. PMID- 42394860 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Development and validation of a food frequency questionnaire for national nutrition surveillance among Malaysian adolescents and adults. PG - e48 LID - 10.1017/jns.2026.10119 [doi] LID - e48 AB - Food habits vary across ethnic groups and geographical regions. However, validated dietary assessment tools accounting for such diversity remain limited. A semi-quantitative food frequency questionnaire (FFQ) was developed and validated to assess the habitual food intake of adolescents and adults across Malaysia. The 147-item FFQ was constructed using commonly consumed foods from five main ethnicities (Malay, Chinese, Indian, and Sabah and Sarawak indigenous groups) identified from national surveys. A cross-sectional validation study was conducted among purposively sampled healthy individuals aged 10-59 years from 16 administrative regions. Trained community nutritionists administered the FFQ to assess monthly intake, alongside a three-day dietary record and recall (3DRR) covering two weekdays and one weekend. Spearman's correlation, Bland-Altman plots, and quartile cross-classification evaluated the agreement between the FFQ and 3DRR for energy, macronutrients, and selected micronutrients (Vitamin C, thiamine, calcium, and iron). Respondents (n = 361; 50.3% adults, 49.7% adolescents) were 50.4% female and represented five main ethnicities (range: 15.8-25.2%), with 60.4% from Peninsular Malaysia. Energy intake estimated by the FFQ (median: 2285 kcal) was significantly higher than by the 3DRR (median: 1785 kcal; Wilcoxon p < 0.001). Spearman's correlation coefficients observed for energy (crude r = 0.31), and selected nutrients (energy-adjusted r range: 0.19-0.38), along with <10% of extreme quartile misclassification indicated acceptable ranking ability and agreement for most nutrients. Bland-Altman plots indicated no proportional bias for energy and macronutrients. In conclusion, the FFQ is a valid tool for assessing dietary intake within the multi-ethnic Malaysian population nationwide. CI - (c) The Author(s) 2026. FAU - Wong, Kimberly Yuin Y'ng AU - Wong KYY AUID- ORCID: 0000-0002-4745-8735 AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Zainuddin, Ahmad Ali AU - Zainuddin AA AUID- ORCID: 0000-0003-4016-6809 AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Salleh, Ruhaya AU - Salleh R AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Palaniveloo, Lalitha AU - Palaniveloo L AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Baharudin, Azli AU - Baharudin A AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Muhammad, Noor Ul-Aziha AU - Muhammad NU AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Amali, Khairul Hasnan AU - Amali KH AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Husni Zain, Sulhariza AU - Husni Zain S AUID- ORCID: 0000-0003-4155-8089 AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Lai, Wai Kent AU - Lai WK AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 LA - eng PT - Journal Article PT - Validation Study DEP - 20260701 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Adolescent MH - Malaysia MH - Female MH - Adult MH - Male MH - Child MH - Young Adult MH - Energy Intake MH - Cross-Sectional Studies MH - Surveys and Questionnaires/standards MH - *Feeding Behavior MH - Middle Aged MH - *Diet MH - Diet Records MH - *Nutrition Surveys MH - Nutrition Assessment MH - Micronutrients/administration & dosage MH - Nutrients/administration & dosage MH - Reproducibility of Results MH - Ethnicity MH - *Diet Surveys PMC - PMC13323619 OTO - NOTNLM OT - Dietary assessment OT - Food frequency questionnaire OT - Habitual food intake OT - Nutrition epidemiology OT - Validation COIS- All authors declare no conflicts of interest. EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:32 PMCR- 2026/07/01 CRDT- 2026/07/03 05:16 PHST- 2025/10/09 00:00 [received] PHST- 2026/05/15 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/07/03 06:32 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:16 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - S2048679026101190 [pii] AID - 10.1017/jns.2026.10119 [doi] PST - epublish SO - J Nutr Sci. 2026 Jul 1;15:e48. doi: 10.1017/jns.2026.10119. eCollection 2026. PMID- 42394842 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260703 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Physiological load and breath-holding in artistic swimming: a scoping review establishing historical baselines and evidence gaps in the context of the 2022-2025 rule changes. PG - 1855762 LID - 10.3389/fphys.2026.1855762 [doi] LID - 1855762 AB - BACKGROUND: The 2022-2025 scoring system assigns higher difficulty to complex hybrid elements and acrobatics, which consequently necessitate prolonged underwater immersion. Therefore, it is hypothesized that maximizing scores through extended underwater exertion potentially exposes artistic swimmers to increased physiological demands. Since most quantitative data predates the 2022 rules, traditional routine evidence may underrepresent current competitive stress. OBJECTIVE: This scoping review systematically map literature on artistic swimmers' physiological load and apnea characteristics, establishing a historical baseline to identify critical evidence gaps introduced by the 2022-2025 regulatory changes. METHODS: Following PRISMA-ScR guidelines and the PCC framework, a systematic search across four major databases identified peer-reviewed original research reporting physiological load and/or apnea-related outcomes in competitive artistic swimmers. RESULTS: Synthesis of 36 articles revealed: (1) Routine execution triggers autonomic conflict (concurrent sympathetic/parasympathetic activation), producing broad heart rate ranges (~56.5-203.8 bpm) Additionally, chronic sport-specific training is linked to distinct cardiovascular adaptations. (2) Apnea duration in late traditional (pre-2022) routines constitutes 59%-64% of total performance time. Post-routine blood lactate concentrations are reported ~5.93-11.5 mmol/L. The revised regulations assign higher scoring weights to complex hybrid elements(officially defined as a combination of five or more lower-limb movements performed with intentional apnea),which aligns with increased underwater duration (Time Underwater, TU), higher anaerobic metabolic contributions, and instances of post-exercise hypoxemia. (3) The "Base Mark" penalty mechanism (the minimum degree of difficulty applied for non-conforming or failed elements) correlates with increased cognitive load. Studies also report stress-induced cortisol elevations and altered recovery of heart rate variability under these conditions. (4) Adolescent athletes exhibit still-developing anaerobic and cardiovascular systems. Consequently, based on legacy baselines, recent discussions hypothesize that younger athletes performing the high-frequency, prolonged underwater choreography promoted by the new scoring system may be exposed to increased acute hypoxic stress. CONCLUSIONS: Artistic swimming's exertion and prolonged apnea involve autonomic co-activation, high anaerobic demands, and specific psychophysiological responses. Based on theoretical extrapolation from established physiological baselines, it is hypothesized that the 2022-2025 scoring system increases athletes' exposure to cardiovascular and metabolic loading, presenting safety considerations for adolescents. Since most evidence predates 2022, longitudinal research under valid competitive conditions is necessary to assess the new regulations' physiological impacts. SYSTEMATIC REVIEW REGISTRATION: https://osf.io/dxapc/, identifier 10.17605/OSF.IO/DXAPC. CI - Copyright (c) 2026 Zhou, Xiang, Wong, Wong, Zhao and Fan. FAU - Zhou, QiTing AU - Zhou Q AD - Faculty of Education, University of Macau, Macao, Macao SAR, China. FAU - Xiang, Yunan AU - Xiang Y AD - School of Sports Training, Wuhan Sports University, Wuhan, China. FAU - Wong, Soi Po AU - Wong SP AD - Faculty of Education, University of Macau, Macao, Macao SAR, China. FAU - Wong, U Kei AU - Wong UK AD - Faculty of Education, University of Macau, Macao, Macao SAR, China. FAU - Zhao, Yirui AU - Zhao Y AD - Faculty of Education, University of Macau, Macao, Macao SAR, China. FAU - Fan, Wenjing AU - Fan W AD - Faculty of Education, University of Macau, Macao, Macao SAR, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260618 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13322880 OTO - NOTNLM OT - apnea OT - artistic swimming OT - physiological load OT - rule changes OT - scoping review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:32 PMCR- 2026/06/18 CRDT- 2026/07/03 05:16 PHST- 2026/04/14 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/07/03 06:32 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:16 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.3389/fphys.2026.1855762 [doi] PST - epublish SO - Front Physiol. 2026 Jun 18;17:1855762. doi: 10.3389/fphys.2026.1855762. eCollection 2026. PMID- 42394836 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260703 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Effects of acute warm-up intensity and baseline fitness on running performance in adolescents. PG - 1819635 LID - 10.3389/fphys.2026.1819635 [doi] LID - 1819635 AB - This study investigated the interactive effects of acute warm-up intensity and baseline physical fitness on cardiovascular responses and subsequent running performance in adolescents within a school-based physical education setting. In a counterbalanced, repeated-measures crossover design, 132 adolescents completed a low-intensity warm-up (self-paced walking) and a moderate-intensity warm-up (modified interval-based circuit, ~70% estimated HRmax) on separate occasions, each followed by a 20-minute self-paced running task. After quality control, valid running performance data were obtained from 110 participants, and heart rate data were analyzed in a stratified subsample of 100 participants. Baseline fitness was categorized into middle-to-high fitness (grades 1-3) and low fitness (grades 4-5) based on national normative data from the Physical Activity Promotion System. Cardiovascular response, assessed as mean heart rate during the warm-up, and running performance outcomes, including total distance and mean speed, were analyzed using a mixed-effects model. A significant interaction between warm-up intensity and baseline fitness was observed for both total running distance (p = 0.027) and mean running speed (p = 0.030). Following the moderate-intensity warm-up, the middle-to-high fitness group demonstrated greater running distance and speed compared with the low-intensity condition, whereas the same standardized moderate-intensity warm-up did not improve performance in the low-fitness group. The moderate-intensity warm-up elicited higher mean heart rate than the low-intensity warm-up across participants (p < 0.0001), with no significant interaction between warm-up intensity and fitness level. These findings suggest that baseline fitness may moderate the performance response to an acute warm-up in adolescents. Overall, a universal warm-up prescription may not be equally effective across students with varying fitness levels, and individualized, relative-intensity approaches warrant further investigation in school-based physical education settings. CI - Copyright (c) 2026 Kim, Jeong, Park, Song, Kim, Yoon and Hurr. FAU - Kim, Yongwan AU - Kim Y AD - Department of Physical Education, College of Education, Jeonbuk National University, Jeonju, Republic of Korea. FAU - Jeong, Hyun-Chul AU - Jeong HC AD - Department of Physical Education, College of Education, Jeonbuk National University, Jeonju, Republic of Korea. FAU - Park, Suebin AU - Park S AD - Department of Physical Education, College of Education, Jeonbuk National University, Jeonju, Republic of Korea. FAU - Song, Eun Young AU - Song EY AD - Department of Physical Education, College of Education, Jeonbuk National University, Jeonju, Republic of Korea. AD - Center for Sports Science in Jeonbuk, Jeonbuk State Sports Council, Jeonju, Republic of Korea. FAU - Kim, Hyunji AU - Kim H AD - Department of Physical Education, College of Education, Jeonbuk National University, Jeonju, Republic of Korea. FAU - Yoon, Juseok AU - Yoon J AD - Department of Physical Education, College of Education, Jeonbuk National University, Jeonju, Republic of Korea. FAU - Hurr, Chansol AU - Hurr C AD - Department of Physical Education, College of Education, Jeonbuk National University, Jeonju, Republic of Korea. LA - eng PT - Journal Article DEP - 20260618 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13324993 OTO - NOTNLM OT - fitness level OT - heart rate OT - running performance OT - school-based intervention OT - warm-up intensity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/03 06:30 MHDA- 2026/07/03 06:31 PMCR- 2026/06/18 CRDT- 2026/07/03 05:16 PHST- 2026/02/28 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/03 06:31 [medline] PHST- 2026/07/03 06:30 [pubmed] PHST- 2026/07/03 05:16 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.3389/fphys.2026.1819635 [doi] PST - epublish SO - Front Physiol. 2026 Jun 18;17:1819635. doi: 10.3389/fphys.2026.1819635. eCollection 2026. PMID- 42394577 OWN - NLM STAT- Publisher LR - 20260703 IS - 1532-530X (Electronic) IS - 1064-0266 (Linking) DP - 2026 Jul 3 TI - Childhood abuse and neglect are differentially associated with quality of life changes during inpatient treatment for eating disorders. PG - 1-20 LID - 10.1080/10640266.2026.2695319 [doi] AB - Quality of life (QoL) is markedly impaired in eating disorders (EDs) and often remains compromised after treatment. Although adverse childhood experiences (ACEs) are linked to ED severity and prognosis, less is known about how specific ACE subtypes are associated with changes in functional outcomes. A sample of 221 cisgender women inpatients with EDs completed the Childhood Trauma Questionnaire (CTQ) and the Eating Disorder Quality of Life questionnaire (EDQoL) at admission and discharge. Moderation models examined whether ACE dimensions were associated with differences in the association between baseline and discharge QoL, adjusting for age, body mass index, and illness duration. Patients showed marked QoL impairment at admission and significant improvement by discharge. Emotional and physical neglect were differentially associated with QoL change patterns: higher emotional neglect was associated with weaker baseline-discharge continuity, whereas higher physical neglect was associated with stronger continuity. Overall, 54% of patients achieved reliable improvement. Abuse-only and neglect-only profiles were associated with a lower likelihood of reliable QoL improvement compared with no CTQ elevation. Specific forms of childhood adversity, particularly neglect, are differentially associated with short-term functional recovery during inpatient treatment for EDs, highlighting the relevance of ACE-informed, subtype-sensitive clinical approaches. FAU - Meneguzzo, Paolo AU - Meneguzzo P AUID- ORCID: 0000-0003-3323-6071 AD - Department of Neuroscience, University of Padova, Padova, Italy. AD - Padova Neuroscience Center, University of Padova, Padova, Italy. FAU - Bucci, Enrica AU - Bucci E AD - Eating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Vicenza, Italy. AD - Psycho-Nutritional Center, Verona-Vicenza, Italy. FAU - Pillan, Anna AU - Pillan A AD - Eating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Vicenza, Italy. AD - Psycho-Nutritional Center, Verona-Vicenza, Italy. FAU - Marzotto, Anna AU - Marzotto A AD - Eating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Vicenza, Italy. AD - Psycho-Nutritional Center, Verona-Vicenza, Italy. FAU - Garolla, Alice AU - Garolla A AD - Eating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Vicenza, Italy. AD - Psycho-Nutritional Center, Verona-Vicenza, Italy. FAU - Bonello, Elisa AU - Bonello E AD - Eating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Vicenza, Italy. AD - Psycho-Nutritional Center, Verona-Vicenza, Italy. FAU - Pettenuzzo, Filippo AU - Pettenuzzo F AD - Eating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Vicenza, Italy. AD - Psycho-Nutritional Center, Verona-Vicenza, Italy. FAU - Buscaglia, Francesca AU - Buscaglia F AD - Eating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Vicenza, Italy. AD - Psycho-Nutritional Center, Verona-Vicenza, Italy. FAU - Todisco, Patrizia AU - Todisco P AD - Eating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Vicenza, Italy. AD - Psycho-Nutritional Center, Verona-Vicenza, Italy. LA - eng PT - Journal Article DEP - 20260703 PL - United States TA - Eat Disord JT - Eating disorders JID - 9315161 SB - IM EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:31 CRDT- 2026/07/03 04:23 PHST- 2026/07/03 06:31 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 04:23 [entrez] AID - 10.1080/10640266.2026.2695319 [doi] PST - aheadofprint SO - Eat Disord. 2026 Jul 3:1-20. doi: 10.1080/10640266.2026.2695319. PMID- 42393793 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260813 IS - 1743-0003 (Electronic) IS - 1743-0003 (Linking) VI - 23 IP - 1 DP - 2026 Jul 2 TI - Determination of cut-off points for the Move4 accelerometer and assessment of energy expenditure in children and adolescents aged 6-16 years using manual wheelchairs: a validation and calibration study. LID - 10.1186/s12984-026-02085-5 [doi] LID - 204 AB - BACKGROUND: The present study aimed to determine activity intensity and validate the Move4 accelerometer and derive cut-off points to accurately classify wheelchair-based physical activity (PA) in children and adolescents. METHODS: A calibration and validation study with a test-retest design was performed in 24 children and adolescents (mean age 9.9 +/- 3.2 years; 50% girls) using manual wheelchairs. Participants used a manual wheelchair as their primary mode of mobility and were able propelling the wheelchair independently. Participants completed standardized activities while wearing Move4 sensors at the wrist, upper arm, and chest. In a subsample of 7 children and adolescents, energy expenditure was recorded using portable metabolic cart. Mean Amplitude Deviation (MAD) and Movement Acceleration Intensity (MAI) were processed to derive cut-off points for sedentary, light, moderate, and vigorous PA using CART models, and validity was assessed via Metabolic Equivalent (MET) and heart-rate responses. RESULTS: Both MAD and MAI values increased systematically across activity intensities, supporting good criterion validity. MET values showed progression from sedentary to vigorous tasks. Intensity-specific cut-off points were successfully established for all sensor placements, with consistently higher thresholds for MAI. Sensitivity and specificity analyses indicated the most balanced performance for the upper arm (MAD) and chest (MAI). Test-retest comparisons showed greater variability for MAD-based cut-offs, whereas MAI thresholds demonstrated higher stability, with deviations of approximately 4-5%. CONCLUSIONS: While both MAD and MAI validly reflected PA intensity, MAI showed greater temporal stability and test-retest robustness. These findings support the use of accelerometery for classifying PA in children and adolescents using wheelchairs and underscore the importance of selecting appropriate metrics and sensor positions. CI - (c) 2026. The Author(s). FAU - Seemuller, Selina AU - Seemuller S AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany. Selina.seemueller@fau.de. FAU - Reimers, Anne Kerstin AU - Reimers AK AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany. FAU - Meixner, Benedikt AU - Meixner B AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany. AD - Integrative and Experimental Exercise Science & Training, Julius-Maximilians-Universitat Wurzburg, Wurzburg, Germany. FAU - Engel, Florian AU - Engel F AD - Integrative and Experimental Exercise Science & Training, Julius-Maximilians-Universitat Wurzburg, Wurzburg, Germany. FAU - Beck, Franziska AU - Beck F AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany. LA - eng PT - Journal Article PT - Validation Study DEP - 20260702 PL - England TA - J Neuroeng Rehabil JT - Journal of neuroengineering and rehabilitation JID - 101232233 SB - IM MH - Humans MH - Female MH - Child MH - Adolescent MH - *Energy Metabolism/physiology MH - *Accelerometry/instrumentation/methods/standards MH - *Wheelchairs MH - Male MH - Calibration MH - Reproducibility of Results PMC - PMC13330353 COIS- Declarations. Ethics approval and consent to participate: The study was approved by the local Ethics Committee (Ref. No. 24-345-S) and was in accordance with the 1964 Declaration of Helsinki. All the participants or their parents/legal guardians, in case of minors, signed a written informed consent. Consent for publication: All participants gave their written consent. Competing interests: The authors declare no competing interests. EDAT- 2026/07/03 10:10 MHDA- 2026/07/03 10:11 PMCR- 2026/07/02 CRDT- 2026/07/03 00:19 PHST- 2026/02/11 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/07/03 10:11 [medline] PHST- 2026/07/03 10:10 [pubmed] PHST- 2026/07/03 00:19 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - 10.1186/s12984-026-02085-5 [pii] AID - 2085 [pii] AID - 10.1186/s12984-026-02085-5 [doi] PST - epublish SO - J Neuroeng Rehabil. 2026 Jul 2;23(1):204. doi: 10.1186/s12984-026-02085-5. PMID- 42393619 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 3 TI - Exposure to air pollutants is associated with adverse changes in hemoglobin trajectories and an increased risk of anemia in children and adolescents. LID - 10.1186/s12889-026-27895-z [doi] LID - 2837 AB - BACKGROUND: Air pollution is associated with anemia in children, however, longitudinal data supporting this association are insufficient. METHODS: From 2019 to 2023, we conducted a dynamic cohort study involving 33,900 participants from 119 primary and secondary schools across 16 districts in Shanghai. We obtained the daily average concentrations of five air pollutants (PM(2.5), O(3), NO(2), SO(2), and CO) based on school addresses using the China High Air Pollutants (CHAP) dataset to assess the exposure levels of the study subjects. We used latent class mixed models to determine the longitudinal trajectories of hemoglobin (Hb) and multinomial logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) between trajectory categories. Linear and logistic regression models were used to evaluate the associations between air pollutant exposure level and Hb and anemia risk, respectively, and Cox regression models was used for longitudinal validation. Interaction terms for gender, age, and body mass index (BMI) were used to explore the modifying effects of these factors. RESULTS: At the baseline survey, 3,213 students (9.48%) were identified as anemic, with a higher proportion of girls (63.8%). During an average follow-up period of 3.16 years, 1,685 participants (4.9%) were observed to develop anemia. Children's hemoglobin levels showed three different trajectory patterns throughout the study period. Exposure to PM(2.5) [OR (95% CI) = 2.124(1.853, 2.433)] was associated with adverse trajectory changes characterized by "low hemoglobin". Longitudinal analysis shows that exposure to PM(2.5) [HR = 1.213, 95% CI: (1.068, 1.376)], NO(2) [HR = 1.409, 95% CI: (1.254, 1.584)], and SO(2) [HR = 1.268, 95% CI: (1.172, 1.372)] is associated with an increased risk of anemia. Stratified analysis showed that the adverse effects of PM(2.5) exposure on anemia were more pronounced in younger or underweight children. The adverse effects of NO(2) exposure on anemia were more significant in older or obese children. The association between SO(2) exposure and the impact on anemia mainly appeared in male or younger children. CONCLUSIONS: Long-term exposure to air pollutants is associated with an increased burden of anemia in children and adolescents, and attention should be focused on vulnerable groups such as girls and underweight children. CI - (c) 2026. The Author(s). FAU - Zheng, Keyang AU - Zheng K AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Zhang, Fengyun AU - Zhang F AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Chu, Liting AU - Chu L AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Yang, Yanting AU - Yang Y AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Sun, Lijing AU - Sun L AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Huang, Yuting AU - Huang Y AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Qu, Shuangxiao AU - Qu S AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Huang, Shenglei AU - Huang S AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Qi, Wenjuan AU - Qi W AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Yang, Dongling AU - Yang D AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. yangdongling@scdc.sh.cn. FAU - Luo, Chunyan AU - Luo C AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. luochunyan_ess@163.com. LA - eng GR - GWVI-7/The Sixth Round of Shanghai Public Health Three Year Action Project (2023-2025)/ PT - Journal Article DEP - 20260703 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Air Pollutants) RN - 0 (Hemoglobins) RN - 0 (Particulate Matter) SB - IM MH - Humans MH - *Anemia/epidemiology/chemically induced MH - Female MH - Male MH - *Air Pollutants/adverse effects/analysis MH - China/epidemiology MH - Child MH - *Hemoglobins/analysis MH - *Environmental Exposure/adverse effects/analysis MH - Adolescent MH - Particulate Matter/adverse effects/analysis MH - *Air Pollution/adverse effects/analysis MH - Longitudinal Studies MH - Cohort Studies PMC - PMC13644236 OTO - NOTNLM OT - Adolescent OT - Air pollution OT - Anemia OT - Children OT - Hemoglobin COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. The study was approved by the Ethics Committee of the Shanghai Municipal Center for Disease Control and Prevention (No.2022-13). Participants and their guardians signed informed consent prior to data collection and informed consent was obtained from all included participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/03 06:31 MHDA- 2026/10/07 05:31 PMCR- 2026/07/03 CRDT- 2026/07/03 00:09 PHST- 2025/12/23 00:00 [received] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/10/07 05:31 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 00:09 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - 10.1186/s12889-026-27895-z [pii] AID - 27895 [pii] AID - 10.1186/s12889-026-27895-z [doi] PST - epublish SO - BMC Public Health. 2026 Jul 3;26(1):2837. doi: 10.1186/s12889-026-27895-z. PMID- 42393595 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260905 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jul 2 TI - Association of albumin-based inflammatory indices with adverse neonatal outcomes in intrahepatic cholestasis of pregnancy: a retrospective comparative study. LID - 10.1186/s12884-026-09555-7 [doi] LID - 990 AB - OBJECTIVE: To evaluate whether albumin-based inflammatory indices are associated with perinatal and neonatal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy (ICP). METHODS: This retrospective comparative study included 277 pregnant women who delivered at a tertiary referral center between January 2020 and December 2025 (ICP, n = 90; controls, n = 187). Albumin-based inflammatory indices were calculated from routine laboratory parameters obtained during the week of delivery. Perinatal and neonatal outcomes were compared between groups. Within the ICP group, associations between inflammatory indices and adverse outcomes were evaluated, and multivariable logistic regression analysis was performed to identify independent predictors within the ICP group of neonatal intensive care unit (NICU) admission. RESULTS: Gestational age at delivery and neonatal birth weight were significantly lower in the ICP group, while rates of preterm birth, low birth weight, and NICU admission were significantly higher compared with controls. Albumin-based inflammatory indices did not differ significantly between groups. Within the ICP group, low birth weight (< 2500 g) was associated with higher NAR (p = 0.031), whereas LAR (p = 0.094) and MAR (p = 0.129) were not statistically significant. NICU admission was associated with higher leukocyte-to-albumin ratio (LAR) (p = 0.036), neutrophil-to-albumin ratio (NAR) (p = 0.032), and monocyte-to-albumin ratio (MAR) (p = 0.017) in univariable analyses. In multivariable logistic regression analysis, higher LAR (OR 1.818, 95% CI 1.026-3.223; p = 0.041) and preterm birth < 37 weeks (OR 6.119, 95% CI 2.145-17.457; p = 0.001) remained independently associated with NICU admission. Exploratory ROC analysis performed within the ICP group demonstrated limited discriminatory performance for all evaluated indices, with modest accuracy observed for LAR (AUC = 0.67) and MAR (AUC = 0.65), whereas other indices, including NPAR (p = 0.455) and CAR (p = 0.065), showed poor and non-significant discriminatory performance. CONCLUSION: Albumin-based inflammatory indices demonstrated limited overall clinical utility in pregnancies complicated by ICP. Among these indices, leukocyte-to-albumin ratio was associated with NICU admission, suggesting a possible association between leukocyte-related inflammatory burden and neonatal outcomes. However, this finding should be interpreted with caution given the limited discriminatory performance of the evaluated indices and the potential for residual confounding. Further prospective studies are needed to validate this observation. CI - (c) 2026. The Author(s). FAU - Cicek, Sevil AU - Cicek S AUID- ORCID: 0000-0001-6147-8102 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. svlerslnn@gmail.com. FAU - Kapudere, Bilge AU - Kapudere B AUID- ORCID: 0000-0002-5622-3161 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Kaya Parspanci, Yasemin Beyza AU - Kaya Parspanci YB AUID- ORCID: 0000-0001-9639-7484 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Tavukcuoglu, Zehra AU - Tavukcuoglu Z AUID- ORCID: 0000-0001-6951-4761 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Soyupak, Berkay AU - Soyupak B AUID- ORCID: 0000-0003-0907-8608 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Eyiceoglu, Merve Amine AU - Eyiceoglu MA AUID- ORCID: 0009-0007-4435-693X AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Kutay Yilmaz, Feyza AU - Kutay Yilmaz F AUID- ORCID: 0000-0002-9575-5291 AD - Artvin Central Community Health Center, Artvin, Turkey. FAU - Ayaz, Reyhan AU - Ayaz R AUID- ORCID: 0000-0001-5261-1792 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260702 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Serum Albumin) RN - 0 (Biomarkers) RN - Intrahepatic Cholestasis of Pregnancy SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Cholestasis, Intrahepatic/blood/complications MH - Retrospective Studies MH - *Pregnancy Complications/blood MH - Adult MH - Infant, Newborn MH - Pregnancy Outcome MH - Intensive Care Units, Neonatal/statistics & numerical data MH - Premature Birth/epidemiology MH - *Serum Albumin/analysis MH - Gestational Age MH - *Inflammation/blood MH - Biomarkers/blood MH - Infant, Low Birth Weight MH - Birth Weight PMC - PMC13540199 OTO - NOTNLM OT - Albumin OT - Biomarkers OT - Inflammation OT - Intrahepatic cholestasis of pregnancy OT - NICU OT - Neonatal outcomes COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Non-Interventional Clinical Research Ethics Committee of Goztepe Prof. Dr. Suleyman Yalcin City Hospital (Approval No: 2025/0101; Date: 13 August 2025). Due to the retrospective design of the study, the requirement for informed consent was waived. All procedures were conducted in accordance with the Declaration of Helsinki, and patient data were anonymized prior to analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/03 06:31 MHDA- 2026/09/04 05:36 PMCR- 2026/07/02 CRDT- 2026/07/03 00:07 PHST- 2026/02/16 00:00 [received] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/09/04 05:36 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 00:07 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - 10.1186/s12884-026-09555-7 [pii] AID - 9555 [pii] AID - 10.1186/s12884-026-09555-7 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jul 2;26(1):990. doi: 10.1186/s12884-026-09555-7. PMID- 42393133 OWN - NLM STAT- Publisher LR - 20260702 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 2 TI - Expression and clinical significance of miR-223 in children with severe pneumonia. LID - 10.1038/s41598-026-59418-6 [doi] AB - Severe pneumonia poses a major life-threatening respiratory disease among children under 5 years old, and conventional laboratory markers lack sufficient specificity for its early identification and severity evaluation, highlighting an urgent need for novel sensitive and specific biomarkers. This study enrolled 107 children diagnosed with severe pneumonia and 107 age- and gender-matched healthy children from January 2024 to June 2025. Quantitative real-time PCR was applied to detect plasma miR-223 expression, and routine hematological, biochemical and coagulation indicators were simultaneously collected for all subjects. Statistical analyses including Mann-Whitney U test, multivariate logistic regression and ROC curve analysis were performed to explore the diagnostic value of miR-223. Plasma miR-223 expression was significantly elevated in children with severe pneumonia compared with healthy controls, and multivariate logistic regression identified miR-223, neutrophil percentage, albumin and fibrinogen as independent risk factors for pediatric severe pneumonia. Single miR-223 yielded an AUC of 0.90 for disease diagnosis, while the combined model of the four indicators achieved an AUC up to 0.99 with superior diagnostic accuracy and sensitivity. Age stratification analysis revealed that miR-223 upregulation existed across all age subgroups of patients, and age exerted no significant interference on its diagnostic performance. Moreover, higher miR-223 levels were correlated with severe complications, PICU admission and longer hospital stays, indicating its potential for disease stratification and short-term prognosis assessment. In summary, plasma miR-223 acts as a reliable molecular biomarker for pediatric severe pneumonia, and its combination with routine inflammatory, nutritional and coagulation markers greatly improves diagnostic efficiency, which provides a promising auxiliary tool for early diagnosis and clinical risk evaluation of children with severe pneumonia. CI - (c) 2026. The Author(s). FAU - Wang, Min AU - Wang M AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Wang, Juan AU - Wang J AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Chen, Mengmeng AU - Chen M AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Hu, Chong AU - Hu C AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Zhang, Yanzi AU - Zhang Y AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Zhu, Lingdong AU - Zhu L AUID- ORCID: 0000-0003-4630-9305 AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. zhulingdong_sduch@163.com. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. zhulingdong_sduch@163.com. LA - eng GR - 2023-2-139/Science and Technology Development Program of Jinan Municipal Health Commission/ PT - Journal Article DEP - 20260702 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Children OT - MicroRNA-223 OT - Serum OT - Severe pneumonia COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics statement: Ethical approval this study was approved by the Ethical Committee of Children's Hospital affiliated to Shandong University approval number: SDFE-IRB/P-2023031). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent: The requirement to obtain informed consent was waived. EDAT- 2026/07/03 04:10 MHDA- 2026/07/03 04:10 CRDT- 2026/07/02 23:21 PHST- 2026/01/26 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/07/03 04:10 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 23:21 [entrez] AID - 10.1038/s41598-026-59418-6 [pii] AID - 10.1038/s41598-026-59418-6 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 2. doi: 10.1038/s41598-026-59418-6. PMID- 42393014 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 2191-0278 (Electronic) IS - 0334-0139 (Linking) VI - 38 IP - 5 DP - 2026 Oct 1 TI - Cross-cultural adaptation and preliminary validation of the adolescent obesity environmental questionnaire (AOEQ) in LMICs: family, school, and peer contexts. PG - 369-375 LID - 10.1515/ijamh-2026-0037 [doi] AB - OBJECTIVES: Although adolescent obesity is a growing concern in low- and middle-income countries (LMICs), culturally adapted tools to assess environmental risk factors are limited. This study developed and conducted a preliminary validation of the Adolescent Obesity Environmental Questionnaire (AOEQ), with a design intended to be relevant for LMIC contexts. METHODS: Items were generated via literature review, adaptation of existing tools, and focus group discussions. Forward-backward translation and expert panel review ensured content validity. Five experts rated items using Content Validity Index (CVI), and face validity was evaluated with adolescents (FVI). RESULTS: The preliminary AOEQ included 40 items across three domains: family (27), school (6), and peer (7). Expert review showed high content validity (S-CVI/Ave=0.90; I-CVI 0.83-1.00). Face validity confirmed clarity and cultural appropriateness (S-FVI/Ave=0.94). Internal consistency was high (Cronbach's alpha=0.813-0.948). CONCLUSIONS: The AOEQ is a reliable, culturally valid tool for assessing obesogenic environments among Indonesian adolescents, with potential applicability to other adolescents in LMIC settings. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Erlena, Erlena AU - Erlena E AUID- ORCID: 0000-0002-4019-9443 AD - Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. AD - Faculty of Science, Horizon University, Karawang, Indonesia. FAU - Nurjannah, Intansari AU - Nurjannah I AD - Nursing Science Study Program, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. FAU - Achadiono, Deddy Nurwachid AU - Achadiono DN AD - Gadjah Mada University Faculty of Medicine, Dr. Sardjito, Yogyakarta, Indonesia. FAU - Wibawa, Tri AU - Wibawa T AUID- ORCID: 0000-0003-0477-4575 AD - Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. LA - eng PT - Journal Article PT - Validation Study DEP - 20260706 PL - Germany TA - Int J Adolesc Med Health JT - International journal of adolescent medicine and health JID - 8506960 SB - IM MH - Humans MH - Adolescent MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Female MH - *Pediatric Obesity MH - Developing Countries MH - Indonesia MH - Schools MH - Peer Group MH - Male MH - Family MH - Cross-Cultural Comparison MH - Psychometrics MH - Focus Groups MH - Risk Factors OTO - NOTNLM OT - Indonesia OT - adolescent obesity OT - environmental factors OT - low- and middle-income countries (LMICs) OT - questionnaire validation EDAT- 2026/07/03 04:10 MHDA- 2026/10/23 18:30 CRDT- 2026/07/02 23:02 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/10/23 18:30 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 23:02 [entrez] AID - ijamh-2026-0037 [pii] AID - 10.1515/ijamh-2026-0037 [doi] PST - epublish SO - Int J Adolesc Med Health. 2026 Jul 6;38(5):369-375. doi: 10.1515/ijamh-2026-0037. eCollection 2026 Oct 1. PMID- 42392592 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jul 2 TI - Development and Validation of an Explainable Machine Learning Model to Assess the Prevalence Probability of Gastrointestinal Heat Retention Syndrome in Children: Cross-Sectional Study. PG - e94775 LID - 10.2196/94775 [doi] LID - e94775 AB - BACKGROUND: Health problems associated with energy metabolism imbalance have received increasing attention. Our team was the first to propose the concept of gastrointestinal heat retention syndrome (GHRS). Triggered by high-calorie diets and excessive energy intake, GHRS is strongly associated with recurrent respiratory infections and other pediatric conditions in children. Existing research on GHRS has primarily focused on risk factor analyses, and no interpretable exploratory self-assessment model for estimating prevalence probability is currently available for routine household use. OBJECTIVE: This study aims to develop and validate an interpretable machine learning model to help caregivers conduct exploratory self-assessments of the probability that children meet the criteria for pediatric GHRS and to provide a practical assessment tool for household use. METHODS: This study conducted a questionnaire survey of kindergarten children in Longgang District, Shenzhen, China. Samples with missing information on GHRS-related symptoms and signs were excluded. Independent correlates were identified using univariate logistic analysis, collinearity testing, Least Absolute Shrinkage and Selection Operator regression, and multivariable logistic regression. After handling missing data and preprocessing, the dataset was randomly divided into training and test sets in an 8:2 ratio. SMOTETomek (Synthetic Minority Oversampling Technique Tomek Links) was included as a conservative resampling step in the training pipeline, and optimal features were selected using a combination of Pearson correlation analysis and recursive feature elimination. In addition, a Random Forest (RF) sensitivity analysis without SMOTETomek was performed, and the minimum required sample size was estimated according to the events per variable (EPV) rule. Seven machine learning models were developed and evaluated in terms of discrimination, calibration, and clinical utility. The SHAP (Shapley Additive Explanations) method was used to interpret the optimal model, which was subsequently deployed online using the Streamlit framework. RESULTS: A total of 120,198 questionnaires were collected, of which 108,447 were deemed valid and included in the analysis. The ratio of GHRS-positive to GHRS-negative cases was nearly balanced. The study identified 59 independent correlates of GHRS, including 10 protective factors and 49 risk factors. After data cleaning, a complete-case dataset of 49,798 participants was obtained, exceeding the minimum sample size requirement of 3747 cases based on the EPV rule. During internal validation, the RF model demonstrated acceptable discriminatory performance, stable calibration, and high net benefit in decision curve analysis, and was therefore selected as the primary analytical model. SHAP analysis identified 5 key predictive features. The resulting online tool collects information through 75 single-choice questions and automatically provides an estimated probability of GHRS together with lifestyle recommendations. CONCLUSIONS: Using cross-sectional data, this study developed and validated an interpretable model that enables caregivers to perform exploratory self-assessments of the probability that children meet the study-specific GHRS scale criteria. As a household self-screening tool, the model helps caregivers estimate this probability based on readily obtainable information and model-generated risk estimates. CI - (c)Senlong Hou, Jiyu Jiang, Xue Li, Mingze Yang, Qilin Chen, Xueyan Ma, Xiaohong Gu. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 02.07.2026. FAU - Hou, Senlong AU - Hou S AUID- ORCID: 0009-0005-1578-261X AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Jiang, Jiyu AU - Jiang J AUID- ORCID: 0009-0006-9994-546X AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Li, Xue AU - Li X AUID- ORCID: 0009-0006-6977-0419 AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Yang, Mingze AU - Yang M AUID- ORCID: 0009-0003-7604-2493 AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Chen, Qilin AU - Chen Q AUID- ORCID: 0009-0003-0501-5949 AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Ma, Xueyan AU - Ma X AUID- ORCID: 0000-0001-8622-7967 AD - Institute of Epidemic Diseases, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. FAU - Gu, Xiaohong AU - Gu X AUID- ORCID: 0000-0001-8361-9455 AD - Institute of Epidemic Diseases, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260702 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - *Machine Learning MH - Cross-Sectional Studies MH - Child MH - Prevalence MH - Female MH - *Gastrointestinal Diseases/epidemiology MH - Male MH - Child, Preschool MH - China/epidemiology MH - Surveys and Questionnaires PMC - PMC13376857 OTO - NOTNLM OT - energy metabolism OT - explainability OT - gastrointestinal heat retention syndrome OT - machine learning OT - prevalence probability assessment model COIS- Conflicts of Interest: None declared. EDAT- 2026/07/03 04:10 MHDA- 2026/07/03 04:11 PMCR- 2026/07/02 CRDT- 2026/07/02 19:53 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/03 00:00 [revised] PHST- 2026/07/03 04:11 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 19:53 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - v28i1e94775 [pii] AID - 10.2196/94775 [doi] PST - epublish SO - J Med Internet Res. 2026 Jul 2;28:e94775. doi: 10.2196/94775. PMID- 42392357 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260730 IS - 1872-8057 (Electronic) IS - 0303-7207 (Linking) VI - 620 DP - 2026 Oct TI - Blood-based microRNAs as biomarkers of insulin resistance in childhood obesity: A systematic review and meta-analysis. PG - 112856 LID - S0303-7207(26)00133-4 [pii] LID - 10.1016/j.mce.2026.112856 [doi] AB - Childhood obesity is closely linked to insulin resistance, but affected children are metabolically heterogeneous. Blood-based microRNAs (miRNAs) have emerged as potential minimally invasive biomarkers of early metabolic dysfunction. A systematic search of PubMed, Embase, Web of Science, and Scopus was conducted from database inception to April 1, 2026. Eligible studies included children or adolescents with obesity that evaluated blood-based miRNAs, including serum, plasma, or peripheral blood mononuclear cell-derived miRNAs, in relation to IR. Narrative synthesis was the primary approach. Study quality was assessed using the Newcastle-Ottawa Scale, and exploratory quantitative synthesis was performed only for comparable miRNA-outcome pairs with extractable correlation data. Twenty studies met the inclusion criteria; 7 were rated as low risk of bias, 11 as moderate risk, and 2 as high risk. Most studies had cross-sectional or case-control designs, and substantial heterogeneity was present in study populations, biological sample source, insulin resistance definitions, miRNA methods, and outcome reporting. Across the included studies, miR-122 was the most consistent candidate, showing recurrent up-regulation in adverse metabolic phenotypes and positive associations with HOMA-IR (r = 0.53; 95%CI, 0.35-0.67) or related IR markers (r = 0.60; 95%CI, 0.47-0.70). miR-29a also showed relatively consistent positive associations (r = 0.67; 95%CI, 0.59-0.73), particularly in cohorts with more severe metabolic impairment. Other candidates, including miR-146a, miR-34a, miR-191-3p, miR-30d-5p, and miR-221-3p, showed relevant but less consistent findings. Blood-based miRNAs are associated with IR in childhood obesity, with miR-122 emerging as the strongest and most recurrent candidate and miR-29a as another promising marker. However, the evidence remains heterogeneous and insufficient for clinical application. Larger, standardized, and longitudinal studies are needed to validate the most recurrent candidates and define their role in early risk stratification. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Wang, Lin AU - Wang L AD - Department of Acupuncture, Qingdao Traditional Chinese Medicine Hospital, Qingdao Hiser Hospital Affiliated of Qingdao University, Qingdao, 266000, China. FAU - Liu, Zhaofen AU - Liu Z AD - Department of Outpatient, Weifang People's Hospital, Weifang, 261041, China. Electronic address: lzf13906368234@outlook.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260702 PL - Ireland TA - Mol Cell Endocrinol JT - Molecular and cellular endocrinology JID - 7500844 RN - 0 (MicroRNAs) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Insulin Resistance/genetics MH - *MicroRNAs/blood/genetics MH - *Biomarkers/blood MH - *Pediatric Obesity/blood/genetics MH - Child OTO - NOTNLM OT - Childhood obesity OT - HOMA-IR OT - Insulin resistance OT - miR-122 OT - miR-29a OT - microRNA COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/03 04:10 MHDA- 2026/07/09 04:10 CRDT- 2026/07/02 19:30 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/09 04:10 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 19:30 [entrez] AID - S0303-7207(26)00133-4 [pii] AID - 10.1016/j.mce.2026.112856 [doi] PST - ppublish SO - Mol Cell Endocrinol. 2026 Oct;620:112856. doi: 10.1016/j.mce.2026.112856. Epub 2026 Jul 2. PMID- 42392350 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1879-176X (Electronic) IS - 0300-5712 (Linking) VI - 175 DP - 2026 Dec TI - Accuracy of 2D facial profile photographs under routine clinical conditions compared with 3D imaging. PG - 106878 LID - S0300-5712(26)00548-8 [pii] LID - 10.1016/j.jdent.2026.106878 [doi] AB - OBJECTIVE: To assess the accuracy of facial soft-tissue profile lines derived from two-dimensional (2D) photographs acquired under routine clinical conditions, using three-dimensional (3D) facial photographs as the reference standard. METHODS: This study analysed pre-existing 2D and 3D facial photographs of 160 orthodontic patients. True facial profile lines were generated from 3D photographs using an automated midsagittal plane based on best-fit superimposition of mirrored surface models. Corresponding profile lines were traced on 2D photographs. Fixed landmarks and sliding semilandmarks were placed on predefined profile curves, and configurations were analysed using geometric morphometrics. Pairwise Procrustes superimposition was performed, and Procrustes distances quantified discrepancies between 2D- and 3D-derived profiles. The effects of age and sex were evaluated. RESULTS: Significant differences were found between 2D-derived and 3D reference profiles (P < 0.001). The median discrepancy was 0.75 mm (IQR 0.79 mm; range 0.01-9.36 mm), with the largest differences in the lip region. Although mean discrepancies were small, variability at the individual level was considerable. Differences exceeding +/-1 mm and +/-2 mm occurred in 35.2% and 8.2% of measurements, respectively. Errors were greater in males and younger subjects, with no significant interaction. CONCLUSIONS: 2D photographs show statistically significant and clinically relevant discrepancies compared with 3D-based profiles. While average errors are small, individual variability should be considered when precise assessment is required. CLINICAL SIGNIFICANCE: Routine 2D facial photographs may be insufficient for accurate individual-level soft-tissue profile assessment. Clinicians should be cautious when using them for diagnosis or treatment planning where precision is critical. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Opacic, Jasmina AU - Opacic J AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Switzerland. FAU - Kanavakis, Georgios AU - Kanavakis G AD - Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, GR-11527 Athens, Greece. FAU - Halazonetis, Demetrios AU - Halazonetis D AD - Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, GR-11527 Athens, Greece. FAU - Gkantidis, Nikolaos AU - Gkantidis N AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Switzerland. Electronic address: nikolaos.gkantidis@unibe.ch. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260702 PL - England TA - J Dent JT - Journal of dentistry JID - 0354422 SB - IM MH - Humans MH - *Imaging, Three-Dimensional/statistics & numerical data/methods/standards MH - *Face/anatomy & histology MH - Male MH - Female MH - Adolescent MH - *Photography/statistics & numerical data/methods/standards MH - Image Processing, Computer-Assisted/statistics & numerical data/methods MH - Anatomic Landmarks/anatomy & histology MH - *Cephalometry/statistics & numerical data/methods MH - Young Adult MH - Age Factors MH - Adult MH - Sex Factors MH - Lip/anatomy & histology MH - Child MH - Reproducibility of Results OTO - NOTNLM OT - Data accuracy OT - Face OT - Geometric morphometrics OT - Midsagittal plane OT - Photography OT - Three-dimensional imaging OT - Two-dimensional imaging COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: D. Halazonetis owns stock in dHAL Software, the company that markets Viewbox 4. Demetrios Halazonetis was not involved in data generation and analysis, and thus, could not affect the study outcomes. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/03 04:10 MHDA- 2026/09/04 23:36 CRDT- 2026/07/02 19:30 PHST- 2026/03/28 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 19:30 [entrez] AID - S0300-5712(26)00548-8 [pii] AID - 10.1016/j.jdent.2026.106878 [doi] PST - ppublish SO - J Dent. 2026 Dec;175:106878. doi: 10.1016/j.jdent.2026.106878. Epub 2026 Jul 2. PMID- 42391866 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1873-4235 (Electronic) IS - 0956-5663 (Linking) VI - 311 DP - 2026 Nov 1 TI - Four-in-one multifunctional CoCu-NC@AuPt nanozyme integrated M13 phage-displayed nanobody based multimodal lateral flow immunoassay for bovine lactoferrin detection. PG - 118970 LID - S0956-5663(26)00602-0 [pii] LID - 10.1016/j.bios.2026.118970 [doi] AB - Bovine lactoferrin (LF) is widely used as a nutritional additive in infant formula and functional foods, but is also a milk allergen. Therefore, rapid and sensitive detection of LF is crucial for ensuring food quality and protecting public health. Here, we report a multimodal lateral flow immunoassay (LFIA) for LF detection that integrates an M13 phage-displayed nanobody (M13-Nb) with a "four-in-one" multifunctional nanozyme, namely an AuPt nanoparticle-loaded CoCu-embedded nitrogen-doped carbon nanocomposite (CoCu-NC@AuPt). The specific M13-Nb against LF was isolated from a naive nanobody library. The synthesized CoCu-NC@AuPt exhibits magnetic, colorimetric, peroxidase-mimetic, and photothermal properties, enabling magnetic enrichment and triple-mode sensing (colorimetric, catalytic colorimetric, and photothermal modes). The proposed assay achieved detection limits of 98 pg/mL, 8.49 pg/mL, and 37 pg/mL for the three detection modes, respectively. Practical applicability was verified in pasteurized milk, UHT milk, and yogurt samples, with recoveries of 86.2%-112.5% and coefficients of variation below 15%. This work provides a reliable and sensitive platform for on-site LF detection and demonstrates the potential of combining CoCu-NC@AuPt nanozyme with phage-displayed nanobodies to improve point-of-care testing performance. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Liu, Wanwan AU - Liu W AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China. FAU - Dong, Wenyi AU - Dong W AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China. FAU - Qiu, Yulou AU - Qiu Y AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. Electronic address: yulou@cjlu.edu.cn. FAU - Zhu, Yutao AU - Zhu Y AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China. FAU - Qiu, Jia AU - Qiu J AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China. FAU - Wang, Jianping AU - Wang J AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. FAU - Qin, Weiwei AU - Qin W AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. FAU - Shentu, Xuping AU - Shentu X AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. Electronic address: stxp@cjlu.edu.cn. FAU - Ye, Zihong AU - Ye Z AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. FAU - Yu, Xiaoping AU - Yu X AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. Electronic address: yxp@cjlu.edu.cn. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260630 PL - England TA - Biosens Bioelectron JT - Biosensors & bioelectronics JID - 9001289 RN - EC 3.4.21.- (Lactoferrin) RN - 0 (Single-Domain Antibodies) RN - 7440-44-0 (Carbon) SB - IM MH - *Lactoferrin/analysis/isolation & purification MH - Animals MH - Cattle MH - Immunoassay/methods MH - *Milk/chemistry MH - *Biosensing Techniques/methods MH - Limit of Detection MH - Bacteriophage M13/chemistry MH - *Single-Domain Antibodies/chemistry MH - Nanocomposites/chemistry/ultrastructure MH - Colorimetry MH - Carbon/chemistry MH - Food Analysis/methods MH - Metal Nanoparticles/chemistry OTO - NOTNLM OT - Lactoferrin OT - Lateral flow immunoassay OT - Multimodal detection OT - Nanobody OT - Nanozyme COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/03 04:10 MHDA- 2026/07/12 00:55 CRDT- 2026/07/02 18:08 PHST- 2026/04/14 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/27 00:00 [accepted] PHST- 2026/07/12 00:55 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 18:08 [entrez] AID - S0956-5663(26)00602-0 [pii] AID - 10.1016/j.bios.2026.118970 [doi] PST - ppublish SO - Biosens Bioelectron. 2026 Nov 1;311:118970. doi: 10.1016/j.bios.2026.118970. Epub 2026 Jun 30. PMID- 42390538 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20261010 IS - 1279-8517 (Electronic) IS - 0930-1038 (Linking) VI - 48 IP - 1 DP - 2026 Jul 2 TI - MRI-based normative orbital anthropometric measurements in pediatric populations: age-related variations and clinical implications. LID - 169 [pii] LID - 10.1007/s00276-026-03940-9 [doi] AB - PURPOSE: Accurate anthropometric data of the pediatric orbit is critical for diagnosing and managing various pediatric orbital pathologies and for planning surgical and reconstructive interventions. The purpose of this study was to establish MRI-based normative anthropometric data for pediatric orbital structures, analyze age-related variations, and evaluate interobserver reliability among expert neuroradiologists. METHODS: This retrospective study included 64 healthy pediatric patients (32 males, 32 females; age range, 1-17 years) who underwent MRI scans for indications unrelated to orbital pathology. Patients were categorized into three age groups: pre-school (3-6 years), school-age (7-12 years), and adolescent (13-17 years). MRI scans acquired at 1.5 Tesla and 3 Tesla were independently evaluated by three neuroradiologists to measure orbital anthropometric parameters, including extraocular muscle dimensions, orbital breadth, orbital height, interzygomatic line length, intercanthal distance, optic nerve sheath width, and optic nerve angle. Statistical analyses included Spearman's correlation, Kruskal-Wallis tests, Mann-Whitney U tests, and intraclass correlation coefficients (ICC) to assess interobserver reliability. RESULTS: Significant positive correlations were identified between patient age and orbital parameters, particularly the interzygomatic line length (Spearman's r = 0.772, p < 0.001). Orbital breadth (right: r = 0.674; left: r = 0.703) and orbital height (right: r = 0.608; left: r = 0.644) also significantly increased with advancing age (all p < 0.001). Interobserver reliability demonstrated excellent reproducibility, with ICC values notably high for orbital breadth (ICC = 0.92, 95% CI: 0.89-0.95) and orbital height (ICC = 0.90, 95% CI: 0.87-0.93). CONCLUSION: MRI-based normative anthropometric measurements provide precise and reliable reference values for pediatric orbital anatomy. These measurements reveal significant age-related developmental trends, enhancing diagnostic accuracy, clinical management, and surgical planning in pediatric orbital conditions. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature. FAU - Gulsever, Cafer Ikbal AU - Gulsever CI AD - Department of Neurosurgery, Hakkari State Hospital, Hakkari, Turkey. cafer.gulsever@gmail.com. FAU - Ates, Alaaddin AU - Ates A AD - Department of Radiology, Hakkari State Hospital, Hakkari, Turkey. FAU - Karli, Elif Hazal AU - Karli EH AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Karapinar, Edanur AU - Karapinar E AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Bayramoglu, Zuhal AU - Bayramoglu Z AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Cakir, Mehmet Semih AU - Cakir MS AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Durak, Gorkem AU - Durak G AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Sencer, Serra AU - Sencer S AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Barburoglu, Mehmet AU - Barburoglu M AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260702 PL - Germany TA - Surg Radiol Anat JT - Surgical and radiologic anatomy : SRA JID - 8608029 SB - IM MH - Humans MH - Child MH - Female MH - Child, Preschool MH - *Magnetic Resonance Imaging MH - Male MH - Adolescent MH - *Orbit/anatomy & histology/diagnostic imaging MH - Retrospective Studies MH - Infant MH - Reproducibility of Results MH - Reference Values MH - Anthropometry/methods MH - Age Factors MH - Observer Variation MH - Oculomotor Muscles/anatomy & histology/diagnostic imaging OTO - NOTNLM OT - Magnetic resonance imaging (MRI) OT - Normative data OT - Orbital anthropometry OT - Orbital measurements OT - Pediatric orbit COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: This study was approved by the Ethics Committee of Istanbul University, Istanbul Faculty of Medicine (Approval No. 12.05.2024-2476179). All procedures were performed in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. Consent to participate: Informed consent was obtained from all individual participants included in this study. For pediatric patients, written consent was provided by a parent or legal guardian prior to participation. Consent to publication: All authors have read and approved the final manuscript and consent to its publication. EDAT- 2026/07/02 12:33 MHDA- 2026/07/02 12:34 CRDT- 2026/07/02 11:03 PHST- 2025/09/24 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/07/02 12:34 [medline] PHST- 2026/07/02 12:33 [pubmed] PHST- 2026/07/02 11:03 [entrez] AID - 10.1007/s00276-026-03940-9 [pii] AID - 10.1007/s00276-026-03940-9 [doi] PST - epublish SO - Surg Radiol Anat. 2026 Jul 2;48(1):169. doi: 10.1007/s00276-026-03940-9. PMID- 42390372 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260905 IS - 2292-9495 (Electronic) IS - 2292-9495 (Linking) VI - 13 DP - 2026 Jul 2 TI - Evaluating the Viability of Virtual Reality for Children's Food Choice Research: Comparative Mixed Methods Study. PG - e88476 LID - 10.2196/88476 [doi] LID - e88476 AB - BACKGROUND: Virtual reality (VR) systems offer promising potential as a controlled platform to investigate human behaviors specifically related to food choices. Yet, little is known about its viability for conducting food choice studies with children, thus limiting the development of public health research. OBJECTIVE: This study aimed to investigate the viability of VR technology for understanding children's food choices, focusing specifically on perceptual differences between VR and real-life (RL) settings. We examined how children perceive and interact with food portion sizes and container sizes in VR as compared with an equivalent RL scenario. METHODS: A within-subject, mixed methods study was conducted with 437 children aged 5-12 years at a science museum. Participants engaged in a standardized food selection task for a simulated breakfast scenario, choosing portions of cereal and milk in 2 conditions: a head-mounted VR environment and a corresponding RL physical setup. Children's food selection behaviors were quantitatively compared across 3 independent variables: condition (VR vs RL), food healthiness (healthy vs unhealthy options), and container size (small, medium, and large). Qualitative and quantitative data were collected via postsession questionnaires assessing presence, embodiment, and simulator sickness, alongside detailed interaction logs from the VR environment. Data analysis used statistical comparisons and thematic analysis. RESULTS: The findings revealed both behavioral consistency and significant perceptual differences between the VR and RL conditions. A behavioral similarity was identified, as children served significantly larger portions of unhealthy food compared with healthy food in both conditions. Crucially, a difference was observed in size perception: children struggled to accurately match the size of bowls and glasses between the VR and RL conditions. Furthermore, while children reported low feelings of presence and embodiment within the VR scenario, they demonstrated a high degree of control and engagement in the virtual task. CONCLUSIONS: Our findings suggest that current state-of-the-art VR technology presents limitations in its viability for conducting food choice studies with children, particularly concerning accurate size and volume perception. Based on the findings, we provide 4 practical recommendations to guide the future development of immersive food environments, thereby supporting more reliable and ecologically valid food choice research with young populations. CI - (c) Deepti Aggarwal, Thuong Hoang, Sze-Yen Tan, Mohammadreza Mohebbi, Catherine G Russell. Originally published in JMIR Human Factors (https://humanfactors.jmir.org). FAU - Aggarwal, Deepti AU - Aggarwal D AUID- ORCID: 0000-0001-8946-4802 AD - School of Information Technology, Faculty of Science Engineering and Built Environment, Deakin University, Geelong, 3125, Australia, 61 92445280 ext 03. FAU - Hoang, Thuong AU - Hoang T AUID- ORCID: 0000-0001-7354-260X AD - School of Information Technology, Faculty of Science Engineering and Built Environment, Deakin University, Geelong, 3125, Australia, 61 92445280 ext 03. FAU - Tan, Sze-Yen AU - Tan SY AUID- ORCID: 0000-0002-9607-202X AD - School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, Australia. FAU - Mohebbi, Mohammadreza AU - Mohebbi M AUID- ORCID: 0000-0001-9713-7211 AD - Faculty of Health, Biostatistics Unit, Deakin University, Geelong, Australia. FAU - Russell, Catherine G AU - Russell CG AUID- ORCID: 0000-0002-0848-2724 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, Australia. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260702 PL - Canada TA - JMIR Hum Factors JT - JMIR human factors JID - 101666561 SB - IM MH - Humans MH - *Virtual Reality MH - Child MH - Male MH - *Food Preferences/psychology MH - Female MH - Child, Preschool MH - *Choice Behavior MH - *Child Behavior PMC - PMC13325622 OTO - NOTNLM OT - children OT - embodiment OT - food choices OT - immersion OT - portion size OT - virtual reality COIS- Conflicts of Interest: None declared. EDAT- 2026/07/02 12:34 MHDA- 2026/07/02 12:35 PMCR- 2026/07/02 CRDT- 2026/07/02 10:24 PHST- 2025/12/01 00:00 [received] PHST- 2026/03/20 00:00 [revised] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/07/02 12:35 [medline] PHST- 2026/07/02 12:34 [pubmed] PHST- 2026/07/02 10:24 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - v13i1e88476 [pii] AID - 88476 [pii] AID - 10.2196/88476 [doi] PST - epublish SO - JMIR Hum Factors. 2026 Jul 2;13:e88476. doi: 10.2196/88476. PMID- 42389673 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260702 LR - 20260813 IS - 2590-1133 (Electronic) IS - 2590-1133 (Linking) VI - 12 DP - 2026 Dec TI - Measuring neurodevelopment in iron-deficient children in sub-Saharan Africa: A systematic review of evidence and gaps. PG - 100274 LID - 10.1016/j.gloepi.2026.100274 [doi] LID - 100274 AB - Anemia and iron-deficiency anemia are prevalent in sub-Saharan Africa (SSA) and linked to impaired brain and developmental outcomes. Progress in understanding these effects is constrained by inconsistent developmental measurement and minimal neuroimaging. This review evaluated how brain growth, cognition, and developmental status have been measured among children under five exposed to anemia, iron deficiency (ID), or iron-deficiency anemia (IDA) in SSA, to assess the availability, reliability, and limitations of neurodevelopmental measurement approaches and implications for comparability and interpretation. A systematic review (PROSPERO CRD42024529208) was conducted following PRISMA guidelines. Six databases were searched for English-language studies published between Jan 1, 2013, and Apr 30, 2024, aligning with the WHO 2013-2025 global nutrition targets. Eligible studies included children aged 0-5 years in SSA exposed to anemia, ID, or IDA and reporting neurodevelopmental outcomes. Findings were synthesized narratively to characterize measurement heterogeneity, reliability reporting, and neuroimaging use. Evidence quality was appraised narratively based on study design and reporting completeness. Of 2254 records screened, 19 studies from nine countries met inclusion criteria. Fourteen studies assessed developmental status, 13 assessed cognition, and only three measured brain outcomes using MRI or near-infrared spectroscopy. Substantial heterogeneity in measurement constructs, assessment tools, cultural adaptations, scoring approaches, and timing of assessment precluded quantitative meta-analysis. Reliability reporting was limited, with psychometric indices reported in seven of 14 developmental studies and nine of 13 cognitive studies. Only three studies incorporated direct measures of brain structure or function, limiting opportunities to relate behavioral outcomes to brain development. Marked measurement heterogeneity, sparse reliability reporting, and the near-absence of neuroimaging constrain epidemiological inference, cross-study comparability, and mechanistic understanding of neurodevelopmental outcomes associated with anemia and ID in SSA. Strengthening culturally grounded assessment frameworks and more equitable, accessible approaches to objective brain measurement are priorities for improving measurement precision and understanding iron-related developmental outcomes. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Vokhiwa, Maclean AU - Vokhiwa M AD - Kamuzu University of Health Sciences (KUHeS), Blantyre, Malawi. AD - Training and Research Unit of Excellence (TRUE), Zomba, Malawi. FAU - Pitchford, Nicola AU - Pitchford N AD - International Centre for EdTech Impact, Stavanger, Norway. FAU - Cohee, Lauren AU - Cohee L AD - Pediatrics and Child Health, Liverpool School of Tropical Medicine, Liverpool, UK. FAU - Phiri, Kamija S AU - Phiri KS AD - Training and Research Unit of Excellence (TRUE), Zomba, Malawi. FAU - Umar, Eric AU - Umar E AD - Kamuzu University of Health Sciences (KUHeS), Blantyre, Malawi. LA - eng PT - Journal Article DEP - 20260619 PL - United States TA - Glob Epidemiol JT - Global epidemiology JID - 101759263 PMC - PMC13320419 OTO - NOTNLM OT - Africa OT - Anemia OT - Iron deficiency OT - Measurement equity OT - Neurodevelopment OT - Neuroimaging COIS- We declare no competing interests. EDAT- 2026/07/02 06:37 MHDA- 2026/07/02 06:38 PMCR- 2026/06/19 CRDT- 2026/07/02 05:09 PHST- 2026/01/14 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/07/02 06:38 [medline] PHST- 2026/07/02 06:37 [pubmed] PHST- 2026/07/02 05:09 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - S2590-1133(26)00033-7 [pii] AID - 100274 [pii] AID - 10.1016/j.gloepi.2026.100274 [doi] PST - epublish SO - Glob Epidemiol. 2026 Jun 19;12:100274. doi: 10.1016/j.gloepi.2026.100274. eCollection 2026 Dec. PMID- 42389040 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260702 LR - 20260813 IS - 2813-4540 (Electronic) IS - 2813-4540 (Linking) VI - 5 DP - 2026 TI - Monitoring physical health in child and adolescent mental health inpatient care: findings from the Y-Health longitudinal feasibility study. PG - 1731769 LID - 10.3389/frcha.2026.1731769 [doi] LID - 1731769 AB - BACKGROUND: Young people with serious mental illness (SMI) face significant physical health inequalities, including increased risk of obesity, diabetes, and other preventable conditions, contributing to a 15-20-year reduction in life expectancy. Those in CAMHS inpatient care are particularly vulnerable due to high levels of psychological distress, psychotropic medication, obesogenic environments and high levels of adverse health behaviours. However, research in this setting is limited. This study aimed to assess the feasibility of monitoring physical health in CAMHS inpatient services, changes to physical and mental health over 6-months and explore young people's experiences of health care. METHODS: A longitudinal feasibility study with a separate qualitative component was conducted across three CAMHS inpatient units, assessing physical and mental health at admission, 3-months and 6-months. Feasibility indicators and clinical outcomes including weight, cardiometabolic markers, lifestyle behaviours and wellbeing were collected through self-report, clinical records and physical health checks. A nested qualitative sub-study was conducted to explore participant experiences of physical health care in CAMHS. RESULTS: Twenty-seven participants were recruited across three CAMHS inpatient units, with 93% (n = 25) retained at 6-month follow-up. Completion of assessments was high at baseline but declined post-discharge. At baseline 37% individuals were overweight or obese, which increased to 50% overweight or obese at follow-up. Metabolic conditions were frequently observed across all timepoints. Physical activity remained low, and diet quality was poor. Mental health and functioning appeared to improve, with reductions in HONOSCA scores suggesting improvements to overall health. CONCLUSION: This study provides the first longitudinal feasibility evidence on monitoring physical health among young people in CAMHS inpatient care, demonstrating high acceptability during admission and identifying substantial challenges with post-discharge monitoring. While descriptive trends indicated a high prevalence of physical health risk factors, the study was not powered to detect meaningful change. These findings highlight the need for integrated, developmentally appropriate models of physical health monitoring across inpatient and community services. CI - (c) 2026 Carney, Imran, Law, Lovell, Ravindrarajah, Fenton, Green, Macafee, Erunkulu and Parker. FAU - Carney, Rebekah AU - Carney R AD - Youth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. AD - Division of Psychology and Mental Health, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. FAU - Imran, Shermin AU - Imran S AD - Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. FAU - Law, Heather AU - Law H AD - Youth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. FAU - Lovell, Karina AU - Lovell K AD - Division of Nursing, Midwifery and Social Work, University of Manchester, Manchester, United Kingdom. FAU - Ravindrarajah, Rathi AU - Ravindrarajah R AD - Division of Nursing, Midwifery and Social Work, University of Manchester, Manchester, United Kingdom. FAU - Fenton, Clare AU - Fenton C AD - Leeds and York Partnership Trust, Leeds, United Kingdom. FAU - Green, Nicola AU - Green N AD - Navigo Child and Adolescent Mental Health Service (Young Minds Matter), Northeast Lincolnshire, United Kingdom. FAU - Macafee, Gillian AU - Macafee G AD - Youth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. FAU - Erunkulu, Olorunleke AU - Erunkulu O AD - Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. FAU - Parker, Sophie AU - Parker S AD - Youth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. AD - Division of Psychology and Mental Health, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Front Child Adolesc Psychiatry JT - Frontiers in child and adolescent psychiatry JID - 9918627188506676 PMC - PMC13319068 OTO - NOTNLM OT - adolescent OT - health behaviour OT - longitudinal studies OT - mental health services OT - metabolic health OT - physical health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author RC declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/07/02 10:10 MHDA- 2026/07/02 10:11 PMCR- 2026/06/17 CRDT- 2026/07/02 05:02 PHST- 2025/10/29 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/07/02 10:11 [medline] PHST- 2026/07/02 10:10 [pubmed] PHST- 2026/07/02 05:02 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - 10.3389/frcha.2026.1731769 [doi] PST - epublish SO - Front Child Adolesc Psychiatry. 2026 Jun 17;5:1731769. doi: 10.3389/frcha.2026.1731769. eCollection 2026. PMID- 42388159 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260922 LR - 20260924 IS - 2287-8572 (Print) IS - 2287-8580 (Electronic) IS - 2287-8572 (Linking) VI - 69 IP - 5 DP - 2026 Sep TI - Predictive value of glycated hemoglobin levels for large for gestational age infants in women with pregestational diabetes according to body mass index. PG - 305-316 LID - 10.5468/ogs.26123 [doi] AB - OBJECTIVE: To evaluate whether pre-pregnancy body mass index (BMI) modifies the predictive ability of glycosylated hemoglobin (HbA1c) for large for gestational age (LGA) infants in women with pregestational diabetes. METHODS: This multicenter retrospective cohort study included 402 women with pregestational diabetes from 17 University Hospitals in South Korea. Pregestational diabetes included early-diagnosed gestational diabetes, type 1 diabetes, and type 2 diabetes. Participants were categorized by pre-pregnancy BMI (<25 vs. >/=25 kg/m2). The primary outcome was LGA birth. Logistic regression was used to assess the association between trimester-specific HbA1c levels and LGA in each BMI group. Receiver operating characteristic (ROC) curve analysis evaluated predictive performance. RESULTS: Among 402 women, 183 (45.5%) had a BMI <25 kg/m2 and 219 (54.5%) had a BMI >/=25 kg/m2. In the BMI <25 kg/m2 group, higher HbA1c levels in all trimesters were significantly associated with an increased risk of LGA, with the strongest association in the third trimester (odds ratio [OR], 2.28; 95% confidence interval [CI], 1.46-3.58). In women with BMI >/=25 kg/m2, only third-trimester HbA1c was significantly associated with LGA (OR, 1.455; 95% CI, 1.069-1.981). ROC analysis showed moderate discrimination for LGA prediction in women with BMI <25 kg/m2 (area under the curve [AUC], 0.70-0.82), but poor discrimination in those with BMI >/=25 kg/m2 (all AUCs /=25 kg/m2. FAU - Lee, Sujin AU - Lee S AD - Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Park, Suyeon AU - Park S AD - Department of Obstetrics and Gynecology, Inha University Hospital, School of Medicine, Inha University, Incheon, Korea. FAU - Sung, Ji-Hee AU - Sung JH AD - Department of Obstetrics and Gynecology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea. FAU - Seol, Hyun-Joo AU - Seol HJ AD - Department of Obstetrics and Gynecology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Korea. FAU - Lee, JoonHo AU - Lee J AD - Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. FAU - Kim, Seung-Chul AU - Kim SC AD - Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Korea. FAU - Choi, Sae-Kyoung AU - Choi SK AD - Department of Obstetrics and Gynecology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Lee, Seung Mi AU - Lee SM AD - Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. FAU - Lee, Se Jin AU - Lee SJ AD - Department of Obstetrics and Gynecology, Kangwon National University Hospital, College of Medicine, Kangwon National University, Chuncheon, Korea. FAU - Hwang, Han-Sung AU - Hwang HS AD - Department of Obstetrics and Gynecology, Konkuk University Hospital, School of Medicine, Konkuk University, Seoul, Korea. FAU - Lee, Gi-Su AU - Lee GS AD - Department of Obstetrics and Gynecology, Keimyung University Dongsan Hospital, School of Medicine, Keimyung University, Daegu, Korea. FAU - Park, Hyun-Soo AU - Park HS AD - Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang, Korea. AD - Family Medicine Residency, Providence St. Joseph Eureka Hospital, College of Medicine, Eureka, CA, USA. FAU - Lee, Soo-Jeong AU - Lee SJ AD - Department of Obstetrics and Gynecology, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea. FAU - Cho, Geum Joon AU - Cho GJ AD - Department of Obstetrics and Gynecology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Korea. FAU - Hong, Subeen AU - Hong S AD - Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. unihsy@catholic.ac.kr. FAU - Ko, Hyun Sun AU - Ko HS AD - Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. mongkoko@catholic.ac.kr. LA - eng GR - Patient-Centered Clinical Research Coordinating Center/ GR - RS-2023-KH137595/Ministry of Health and Welfare/ GR - Catholic Medical Center Research Foundation/ PT - Journal Article DEP - 20260701 PL - Korea (South) TA - Obstet Gynecol Sci JT - Obstetrics & gynecology science JID - 101602614 PMC - PMC13597153 OTO - NOTNLM OT - Body mass index OT - Diabetes mellitus OT - Infant OT - Large for gestational age OT - Pregnancy COIS- Conflict of interest The authors have no conflicts of interest relevant to this study to disclose. EDAT- 2026/07/02 10:10 MHDA- 2026/07/02 10:11 PMCR- 2026/09/01 CRDT- 2026/07/02 04:39 PHST- 2026/04/16 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/02 10:11 [medline] PHST- 2026/07/02 10:10 [pubmed] PHST- 2026/07/02 04:39 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - ogs.26123 [pii] AID - ogs-26123 [pii] AID - 10.5468/ogs.26123 [doi] PST - ppublish SO - Obstet Gynecol Sci. 2026 Sep;69(5):305-316. doi: 10.5468/ogs.26123. Epub 2026 Jul 1. PMID- 42388046 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260813 IS - 2314-6753 (Electronic) IS - 2314-6745 (Print) VI - 2026 IP - 1 DP - 2026 TI - Associations Between a Surrogate Index of Insulin Resistance and Hyperuricemia in Young and Middle-Aged Patients With Type 2 Diabetes Mellitus. PG - e6682372 LID - 10.1155/jdr/6682372 [doi] LID - 6682372 AB - BACKGROUND: This study is aimed at examining the associations between insulin resistance (IR) surrogate indices, including TyG, TyG-BMI, TG/HDL-C, and METS-IR, and hyperuricemia (HUA) in young and middle-aged patients with Type 2 diabetes mellitus (T2DM). METHODS: A total of 1005 patients with T2DM were included in this cross-sectional study. Participants were classified into HUA and nonhyperuricemia (NHUA) groups according to serum uric acid concentrations and further stratified by age into young (18-44 years) and middle-aged (45-59 years) subgroups. Multivariable logistic regression analyses were performed to assess the associations between IR surrogate indices and HUA. Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the discriminatory ability of these indices for HUA across sex- and age-specific subgroups. RESULTS: All IR surrogate indices were significantly higher in the HUA group than in the NHUA group. TyG and TG/HDL-C showed stable associations with HUA across the regression models, while the association for TyG-BMI was attenuated after additional adjustment when modeled continuously, although individuals in the highest quartile remained associated with higher odds of HUA. METS-IR was associated with HUA only in unadjusted models. Age-stratified analyses showed that none of the IR surrogate indices remained significantly associated with HUA after multivariable adjustment in younger patients, whereas TyG and TG/HDL-C remained associated with higher odds of HUA in middle-aged patients. ROC analyses indicated limited to moderate discriminatory performance (AUC < 0.75). TyG-BMI showed the highest AUC in younger patients (AUC = 0.715), while TG/HDL-C demonstrated relatively higher specificity in middle-aged patients. Sex-stratified analyses showed slightly higher AUC values in males than in females, although overall discrimination remained modest. CONCLUSION: IR surrogate indices showed varying associations with HUA in young and middle-aged patients with Type 2 diabetes. TyG and TG/HDL-C showed relatively stable associations with HUA across the regression models, whereas the associations for TyG-BMI and METS-IR were attenuated after additional adjustment. Overall, these indices demonstrated limited discriminatory performance and are not suitable as standalone diagnostic tools but may serve as adjunctive markers for preliminary risk stratification. CI - Copyright (c) 2026 Hongping Wang et al. Journal of Diabetes Research published by John Wiley & Sons Ltd. FAU - Wang, Hongping AU - Wang H AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Yang, Yunyi AU - Yang Y AUID- ORCID: 0000-0001-8280-2901 AD - Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Gao, Jie AU - Gao J AUID- ORCID: 0000-0003-3330-2219 AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Lei, Tao AU - Lei T AUID- ORCID: 0000-0002-5766-5113 AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Xia, Juan AU - Xia J AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Zhang, Cuiping AU - Zhang C AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Shen, Tian AU - Shen T AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Lu, Jun AU - Lu J AUID- ORCID: 0000-0002-8884-6291 AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Liu, Zongjun AU - Liu Z AUID- ORCID: 0000-0003-4993-2354 AD - Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. LA - eng GR - 2023ysxk01/Health System Independent Innovation Science Foundation of Shanghai Putuo District/ GR - 2024tszk02/Clinical Characteristic of Health System in Putuo District, Shanghai/ GR - ptkwws202417/Shanghai Putuo District Health System/ GR - ptkwws202302/Shanghai Putuo District Health System/ GR - ptkwws202217/Shanghai Putuo District Health System/ GR - 202240309/Shanghai Municipal Health Commission/ GR - ptzygzs2409/Putuo Inheritance Studio of Renowned TCM Physician Chen Yuelai, Shanghai/ PT - Journal Article PL - United States TA - J Diabetes Res JT - Journal of diabetes research JID - 101605237 RN - 0 (Biomarkers) RN - 268B43MJ25 (Uric Acid) RN - 0 (Triglycerides) RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/blood/complications/diagnosis MH - *Hyperuricemia/blood/diagnosis/complications MH - *Insulin Resistance/physiology MH - Middle Aged MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Adolescent MH - Biomarkers/blood MH - Young Adult MH - *Uric Acid/blood MH - ROC Curve MH - Body Mass Index MH - Age Factors MH - Triglycerides/blood MH - Cholesterol, HDL/blood MH - Risk Factors PMC - PMC13324239 OTO - NOTNLM OT - Type 2 diabetes mellitus OT - hyperuricemia OT - insulin resistance COIS- The authors declare no conflicts of interest. EDAT- 2026/07/02 10:10 MHDA- 2026/07/02 10:11 PMCR- 2026/07/02 CRDT- 2026/07/02 03:24 PHST- 2026/06/02 00:00 [revised] PHST- 2025/07/10 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/02 10:11 [medline] PHST- 2026/07/02 10:10 [pubmed] PHST- 2026/07/02 03:24 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - JDR6682372 [pii] AID - 10.1155/jdr/6682372 [doi] PST - ppublish SO - J Diabetes Res. 2026;2026(1):e6682372. doi: 10.1155/jdr/6682372. PMID- 42387533 OWN - NLM STAT- MEDLINE DCOM- 20260920 LR - 20260923 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jul 1 TI - Deep learning-based dental age classification from panoramic radiographs: a multi-granularity, multi-model comparative study. LID - 10.1186/s12903-026-09068-x [doi] LID - 1774 AB - OBJECTIVE: To evaluate the performance of a hybrid deep learning architecture, MaxViT-T, for fine-grained dental age estimation (DAE) and coarse-grained age-group classification using panoramic radiographs, and to interpret the model's decision-making process through Explainable AI (XAI). MATERIALS AND METHODS: A dataset of n = 2,761 panoramic radiographs from patients aged 6-18 years was used. Two classification tasks were performed: a 13-class fine-grained age estimation and a 3-group coarse-grained age classification (age ranges 6-9, 10-13, and 14-18 years, approximating the early mixed, late mixed, and permanent dentition periods). The hybrid MaxViT-T model was compared against ten other architectures, including CNNs and Transformers, using 5-fold stratified cross-validation. Model interpretability was assessed using Grad-CAM and SHAP. RESULTS: MaxViT-T achieved the highest performance in both tasks. For the 13-class age estimation, it reached an accuracy of 0.4980 with a Mean Absolute Error (MAE) of 0.71 years. Tolerance-based accuracy increased to 84.9% and 96.1% within 1 and 2 years, respectively. For the 3-group age classification, the model achieved 91.13% accuracy and an AUC of 0.9669. XAI analyses confirmed that the model's attention shifted from deciduous teeth and erupting permanent teeth in younger ages to third molar development in older ages, predominantly focusing on the mandibular region. CONCLUSION: The hybrid MaxViT-T architecture achieved the highest accuracy for dental age estimation among the evaluated models, although its advantage over the leading CNN and Transformer architectures was not statistically significant. Its decision behavior aligned with established odontogenic developmental landmarks, supporting the biological plausibility of the learned features. CI - (c) 2026. The Author(s). FAU - Gorgun, Esin Akol AU - Gorgun EA AUID- ORCID: 0000-0002-6711-7188 AD - Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Adiyaman University, Altinsehir Neighborhood, 3005 Street No:13, Adiyaman, 02040, Turkey. esinakol@adiyaman.edu.tr. FAU - Cakmakoglu, Ezgi Eroglu AU - Cakmakoglu EE AUID- ORCID: 0000-0002-5014-3099 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Adiyaman University, Adiyaman, 02040, Turkey. FAU - Sagmak, Savas AU - Sagmak S AUID- ORCID: 0000-0002-0082-6297 AD - Department of Restorative Dentistry, Faculty of Dentistry, Adiyaman University, Adiyaman, 02040, Turkey. FAU - Kutlu, Huseyin AU - Kutlu H AUID- ORCID: 0000-0003-0091-9984 AD - Department of Biostatistics and Medical Informatics, Faculty of Medicine, Adiyaman University, Adiyaman, 02040, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260701 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Deep Learning MH - *Radiography, Panoramic MH - Child MH - Adolescent MH - *Age Determination by Teeth/methods PMC - PMC13591680 OTO - NOTNLM OT - Deep learning OT - Dental age estimation OT - Explainable artificial intelligence OT - Forensic dentistry OT - Hybrid models OT - Multi-granularity classification COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this retrospective study was obtained from the Adiyaman University Non-Interventional Clinical Research Ethics Committee (Decision No: 2026/2-5). The requirement for informed consent to participate was waived by the same Ethics Committee due to the retrospective design of the study and the use of fully anonymized radiographic data, in accordance with national regulations governing retrospective studies using anonymized clinical data in Turkiye. All procedures were conducted in accordance with the principles of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/02 10:10 MHDA- 2026/09/21 05:34 PMCR- 2026/07/01 CRDT- 2026/07/02 00:53 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/21 05:34 [medline] PHST- 2026/07/02 10:10 [pubmed] PHST- 2026/07/02 00:53 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.1186/s12903-026-09068-x [pii] AID - 9068 [pii] AID - 10.1186/s12903-026-09068-x [doi] PST - epublish SO - BMC Oral Health. 2026 Jul 1;26(1):1774. doi: 10.1186/s12903-026-09068-x. PMID- 42387491 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20260924 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 2 TI - Improving healthy eating behaviour among in-school adolescents through collaborative instructional intervention: a theory-driven quasi-experimental study. LID - 10.1186/s12889-026-28391-0 [doi] LID - 2641 AB - BACKGROUND: Adolescence is a critical window for establishing dietary behaviours that shape long-term health outcomes. In Nigeria and other Sub-Saharan African countries, school-based nutrition education has been largely ineffective when delivered through conventional didactic approaches. This study evaluated the effect of a Health Belief Model-guided collaborative learning intervention on diet quality, nutrition knowledge, and perceived dietary behaviour among in-school adolescents in Ogun State, Nigeria. METHODS: A quasi-experimental, pre-test-post-test control group design was used. Three hundred adolescents aged 13-19 years from two public secondary schools in Odeda Local Government Area were recruited, with 150 assigned to each group. The intervention group received eight weeks of structured nutrition education delivered through collaborative learning techniques, while the control group received the same content through conventional didactic instruction. Diet quality was assessed using the Global Diet Quality Questionnaire (DQQ), nutrition knowledge using a validated 20-item questionnaire, and perceived dietary behaviour using an HBM-based scale. Data were analysed using paired t-tests, independent t-tests, Difference-in-Differences analysis, and ANCOVA. RESULTS: The intervention group demonstrated statistically significant improvements in dietary diversity (DDS: 33.74%), NCD-Protect score (153.22%), and GDR score (39.86%), while the NCD-Risk score showed no significant change in either group (p = 0.967). Nutrition knowledge improved significantly in the intervention group (DiD = 7.94; p = 0.007), with no meaningful change in the control group. All six HBM constructs improved significantly in the intervention group, including self-efficacy (13.46%) and perceived severity (18.96%). ANCOVA confirmed that the intervention independently predicted improvements in both dietary diversity and nutrition knowledge after adjusting for baseline scores and sociodemographic covariates. CONCLUSIONS: The findings of this study suggest that collaborative learning-based nutrition education guided by the Health Belief Model was associated with meaningful improvements in diet quality, nutrition knowledge, and health beliefs among in-school adolescents. These findings support further evaluation of participatory and theory-driven instructional approaches within school-based nutrition programming in Nigeria and similar low-resource settings, ideally through cluster-randomised designs involving larger numbers of schools. CI - (c) 2026. The Author(s). FAU - Ademiluyi, Dare D AU - Ademiluyi DD AUID- ORCID: 0000-0003-3154-3924 AD - Department of Human Nutrition and Dietetics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. ademiluyidare@gmail.com. FAU - Adepoju, Oladejo T AU - Adepoju OT AD - Department of Human Nutrition and Dietetics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. FAU - Oladosu, Gbenga S AU - Oladosu GS AUID- ORCID: 0000-0003-1207-8000 AD - Department of Human Nutrition and Dietetics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. AD - Department of Vocational Education (Home Economics Education Unit), Delta State University, Abraka, Delta State, Nigeria. FAU - Uthman-Akinhanmi, Yewande O AU - Uthman-Akinhanmi YO AUID- ORCID: 0000-0002-1033-2362 AD - Department of Home Science and Hospitality Management (Nutrition and Dietetics Unit), Olabisi Onabanjo University, Ago-iwoye, Ogun State, Nigeria. FAU - Akinsanya, Olubunmi B AU - Akinsanya OB AUID- ORCID: 0000-0002-2753-8463 AD - Department of Human Nutrition and Dietetics, Bells University of Technology, Ota, Ogun State, Nigeria. FAU - Adewale, Ifeyemi O AU - Adewale IO AD - Department of Food Science and Technology (Nutrition and Dietetics Unit), Bell University of Technology, Ota, Ogun State, Nigeria. FAU - Asha, Oluwatoyin E AU - Asha OE AD - Department of Agriculture and Agricultural Technology, Bells University of Technology, Ota, Ogun State, Nigeria. FAU - Olubiyi, Esther D AU - Olubiyi ED AUID- ORCID: 0009-0001-8048-5196 AD - Department of Nutrition and Dietetics, Federal Medical Centre, Abeokuta, Ogun State, Nigeria. FAU - Ojo-Adalumo, Ayobami R AU - Ojo-Adalumo AR AUID- ORCID: 0009-0005-6889-7322 AD - College of Nursing Science, Idi Aba, Abeokuta, Ogun State, Nigeria. FAU - Adepoju, Adeyinka B AU - Adepoju AB AUID- ORCID: 0009-0007-1012-7645 AD - Department of Nutrition and Dietetics, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria. FAU - Ogunniyi, Akinade E AU - Ogunniyi AE AUID- ORCID: 0009-0009-1961-3214 AD - Department of Human Nutrition and Dietetics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. FAU - Oyewunmi, Boluwatife T AU - Oyewunmi BT AUID- ORCID: 0009-0005-1927-4997 AD - Department of Nutrition and Dietetics, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria. LA - eng PT - Journal Article DEP - 20260702 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Nigeria MH - Female MH - *Diet, Healthy/psychology MH - Male MH - Young Adult MH - Health Knowledge, Attitudes, Practice MH - *Health Education/methods MH - Health Belief Model MH - Schools MH - Non-Randomized Controlled Trials as Topic MH - *School Health Services/organization & administration PMC - PMC13595612 OTO - NOTNLM OT - Adolescent nutrition OT - Collaborative learning OT - Diet quality OT - Health Belief Model OT - Nutrition education OT - Nutrition knowledge OT - School-based intervention COIS- Declarations. Ethics approval and consent to participate: Ethical clearance for this study was granted by the Health Research Ethics Committee of the Federal Medical Centre, Abeokuta (FMCA/470/HREC/17/2024/30). Throughout its conduct, the study adhered to internationally accepted ethical standards governing research involving human participants. Participation in this study was entirely voluntary and the study adhered to the tenets of the Helsinki Declaration at all stages. Before data collection commenced, all eligible students and their parents or guardians were provided with full information about the study's objectives, procedures, potential benefits, and the rights of participants. Written informed consent was secured from parents or legal guardians, and written informed assent was obtained from each adolescent participant. Taking part in the study was entirely voluntary, and all participants were made aware of their right to withdraw at any point without facing any consequence. To protect confidentiality, participants were assigned anonymised identification codes, and access to study data was limited strictly to members of the research team. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/02 06:39 MHDA- 2026/09/22 05:37 PMCR- 2026/07/02 CRDT- 2026/07/02 00:50 PHST- 2026/02/23 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/09/22 05:37 [medline] PHST- 2026/07/02 06:39 [pubmed] PHST- 2026/07/02 00:50 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - 10.1186/s12889-026-28391-0 [pii] AID - 28391 [pii] AID - 10.1186/s12889-026-28391-0 [doi] PST - epublish SO - BMC Public Health. 2026 Jul 2;26(1):2641. doi: 10.1186/s12889-026-28391-0. PMID- 42387446 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20260924 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Jul 1 TI - Impact of growth hormone preparation switching on treatment outcomes in children with growth hormone deficiency: a retrospective real-world cohort study. LID - 10.1186/s12902-026-02395-8 [doi] LID - 286 AB - BACKGROUND: Switching between recombinant human growth hormone (rhGH) preparations has become increasingly common in pediatric practice because of reimbursement policies, product availability, and patient preferences. However, concerns persist regarding potential effects on growth outcomes and biochemical responses in real-world settings. This study aimed to evaluate whether switching growth hormone (GH) preparations is associated with differences in growth and biochemical outcomes compared with continuing the same product in children with growth hormone deficiency (GHD). METHODS: This single-center retrospective cohort study included 130 children with GHD receiving GH therapy between 2019 and 2024: 66 who underwent a single switch between preparations and 64 who continued the same product. Annualized changes in height standard deviation score (SDS), height velocity, insulin-like growth factor-1 (IGF-1) SDS, and insulin-like growth factor binding protein-3 (IGFBP-3) SDS were assessed over predefined 12-month observation windows. Patients were additionally stratified according to GHD severity, defined by a peak GH response < 7 ng/mL (severe/complete GHD) or 7-10 ng/mL (partial/borderline GHD). Within-group comparisons were performed using Wilcoxon signed-rank or Friedman tests, and between-group comparisons were performed using Mann-Whitney U tests or chi-square tests, as appropriate. Multivariate linear regression analyses adjusted for age, pubertal status, GH dose, baseline height SDS, and GHD severity. RESULTS: Baseline demographic, auxological, and perinatal characteristics were similar between the groups. In both cohorts, height SDS, IGF-1 SDS, and IGFBP-3 SDS improved significantly during follow-up, whereas GH dose remained stable. When outcomes were compared during equivalent treatment intervals, no significant differences were observed between the switch and nonswitch groups in height velocity (8.72 +/- 2.64 vs. 8.42 +/- 1.62 cm/year; p = 0.108), DeltaHeight SDS (0.53 +/- 0.51 vs. 0.39 +/- 0.37; p = 0.206), DeltaIGF-1 SDS (0.82 +/- 0.69 vs. 0.71 +/- 0.54; p = 0.486), or DeltaIGFBP-3 SDS (0.86 +/- 0.90 vs. 0.64 +/- 0.45; p = 0.283). Similar findings were observed in patients with severe GHD (peak GH < 7 ng/mL). Multivariate regression analysis identified baseline height SDS and GH dose as independent predictors of 12-month height SDS change, whereas switch status and GHD severity were not independently associated with growth response. CONCLUSIONS: Switching between rhGH preparations was not associated with impaired growth or adverse biochemical outcomes in children with GHD. Growth and biochemical responses were comparable between switched and nonswitched patients during equivalent treatment intervals, including among patients with severe GHD. These findings support the clinical feasibility of switching between daily rhGH preparations when required because of reimbursement policies, product availability, or other practical clinical considerations. TRIAL REGISTRATION: Not applicable. CI - (c) 2026. The Author(s). FAU - Deligozoglu, Duygu AU - Deligozoglu D AUID- ORCID: 0000-0002-4804-3048 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. dyg_ertn@hotmail.com. FAU - Gokdemir, Irem AU - Gokdemir I AUID- ORCID: 0009-0002-2967-6437 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Genc, Can Alp AU - Genc CA AUID- ORCID: 0000-0003-0756-9745 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Buyukyilmaz, Gonul AU - Buyukyilmaz G AUID- ORCID: 0000-0001-7888-7295 AD - Department of Pediatric Endocrinology, Ankara Yildirim Beyazit University, Ankara, Turkey. FAU - Cetin, Sirmen Kizilcan AU - Cetin SK AUID- ORCID: 0000-0001-7397-3071 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Isik, Emregul AU - Isik E AUID- ORCID: 0000-0003-0162-6745 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Sengil, Hande Nur AU - Sengil HN AUID- ORCID: 0009-0006-9024-6283 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Tepe, Derya AU - Tepe D AUID- ORCID: 0000-0002-2935-3008 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Kocaay, Pinar AU - Kocaay P AUID- ORCID: 0000-0003-0850-0360 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Boyraz, Mehmet AU - Boyraz M AUID- ORCID: 0000-0002-4289-9128 AD - Department of Pediatric Endocrinology, Ankara Yildirim Beyazit University, Ankara, Turkey. FAU - Gurbuz, Fatih AU - Gurbuz F AUID- ORCID: 0000-0003-2160-9838 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. AD - Department of Pediatric Endocrinology, Ankara Yildirim Beyazit University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260701 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - 12629-01-5 (Human Growth Hormone) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 0 (Recombinant Proteins) RN - 0 (Insulin-Like Growth Factor Binding Protein 3) RN - 0 (IGF1 protein, human) SB - IM MH - Humans MH - Retrospective Studies MH - *Human Growth Hormone/deficiency/therapeutic use/administration & dosage MH - Female MH - Male MH - Child MH - Insulin-Like Growth Factor I/analysis/metabolism MH - Treatment Outcome MH - Body Height/drug effects MH - Follow-Up Studies MH - Recombinant Proteins/administration & dosage MH - *Growth Disorders/drug therapy MH - Adolescent MH - Insulin-Like Growth Factor Binding Protein 3/blood MH - *Drug Substitution MH - Prognosis MH - Child, Preschool PMC - PMC13595697 OTO - NOTNLM OT - Growth hormone deficiency OT - Growth hormone therapy OT - Growth response OT - Real-world study OT - Treatment switch COIS- Declarations. Ethics approval and consent to participate: This retrospective study involving human participant data was approved by the Institutional Ethics Committee of Ankara Bilkent City Hospital (Approval No: 2-24-516; Date: 18 September 2024). The requirement for informed consent to participate was waived by the ethics committee due to the retrospective design of the study, which used anonymized electronic medical records without direct patient contact. All procedures were conducted in accordance with the ethical standards of the institutional research committee and with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/02 06:37 MHDA- 2026/09/22 05:37 PMCR- 2026/07/01 CRDT- 2026/07/02 00:47 PHST- 2026/02/08 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/09/22 05:37 [medline] PHST- 2026/07/02 06:37 [pubmed] PHST- 2026/07/02 00:47 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.1186/s12902-026-02395-8 [pii] AID - 2395 [pii] AID - 10.1186/s12902-026-02395-8 [doi] PST - epublish SO - BMC Endocr Disord. 2026 Jul 1;26(1):286. doi: 10.1186/s12902-026-02395-8. PMID- 42386993 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 7 DP - 2026 Jul 2 TI - Validity and reliability of the Turkish version of the Physical Activity Parenting Questionnaire for Children. LID - 546 [pii] LID - 10.1007/s00431-026-07210-z [doi] AB - Parental practices play a critical role in shaping children's physical activity behaviors, particularly during early school age when parental influence remains strong. The Physical Activity Parenting Questionnaire for Children (PAP-C) is a child-reported, multidimensional instrument designed for children aged 7-10 years; however, no validated Turkish version is currently available. This study aimed to translate, culturally adapt, and evaluate the validity and reliability of the Turkish version of the PAP-C. This methodological, cross-sectional study included 279 children aged 7-10 years attending a pediatric outpatient clinic in Turkiye. The PAP-C was translated and culturally adapted following internationally accepted guidelines. Content validity was assessed. Construct validity was examined using confirmatory factor analysis (CFA). Reliability was evaluated using Cronbach's alpha and McDonald's omega. The study included 279 children (mean age: 8.6 years). The Turkish PAP-C demonstrated strong content validity (S-CVI). Sociodemographic variables showed no significant differences in scale scores, except for higher Involvement scores in children whose fathers had primary school education (p = 0.033). Confirmatory factor analysis confirmed an acceptable to good model fit (CFI: 0.923, TLI: 0.913, RMSEA: 0.055). Standardized factor loadings ranged from 0.599 to 0.866. All subscales exceeded empirical thresholds for convergent validity. The total scale showed good reliability (Omega: 0.951). HTMT values confirmed distinct discriminant validity among the three latent factors. CONCLUSION: The Turkish version of the PAP-C is a valid and reliable instrument for assessing children's perceptions of physical activity related parenting practices. It provides a culturally appropriate tool for both research and clinical assessment. WHAT IS KNOWN: * Parental practices are key determinants of children's physical activity behaviors, and children's perceptions of parenting are closely linked to motivation and engagement. * The Physical Activity Parenting Questionnaire for Children is a child-reported, multidimensional instrument grounded in Self-Determination Theory, capturing three parenting domains (Structure for Activity, Autonomy Support, and Involvement) and has been validated only in limited cultural contexts. WHAT IS NEW: * This study provides the first Turkish translation, cultural adaptation, and psychometric evaluation of the Physical Activity Parenting Questionnaire for Children in children aged 7-10 years. * Content validity was established with high item-level content validity index and scale-level content validity index based on the average method scores, demonstrating strong expert agreement on item relevance and cultural appropriateness. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Sivlim, Harun AU - Sivlim H AUID- ORCID: 0000-0003-3184-5519 AD - Bayburt Provincial Directorate of Health, Bayburt, Turkiye. FAU - Come, Ogulcan AU - Come O AUID- ORCID: 0000-0002-6624-832X AD - Faculty of Medicine, Department of Family Medicine, Dokuz Eylul University, Izmir, Turkey. ogulcancome@gmail.com. FAU - Laukkanen, Arto AU - Laukkanen A AUID- ORCID: 0000-0002-9722-0258 AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. LA - eng PT - Journal Article PT - Validation Study DEP - 20260702 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - Male MH - Reproducibility of Results MH - Turkey MH - Female MH - Cross-Sectional Studies MH - Surveys and Questionnaires/standards MH - *Exercise/psychology MH - *Parenting/psychology MH - Psychometrics MH - Factor Analysis, Statistical MH - Translations MH - Parent-Child Relations OTO - NOTNLM OT - Child-report OT - Parenting practices OT - Physical activity OT - Questionnaire validation OT - Reliability COIS- Declarations. Conflict of interest: The authors declare no competing interests. Declaration of generative AI and AI-assisted technologies: During the preparation of this work, the author(s) used ChatGPT-4o (OpenAI, 2025) in order to improve grammar, language clarity, and phrasing. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication. EDAT- 2026/07/02 00:33 MHDA- 2026/07/02 00:34 CRDT- 2026/07/01 23:42 PHST- 2026/02/03 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/06/21 00:00 [revised] PHST- 2026/07/02 00:34 [medline] PHST- 2026/07/02 00:33 [pubmed] PHST- 2026/07/01 23:42 [entrez] AID - 10.1007/s00431-026-07210-z [pii] AID - 10.1007/s00431-026-07210-z [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 2;185(7):546. doi: 10.1007/s00431-026-07210-z. PMID- 42386292 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 7 DP - 2026 Jul 1 TI - Physical Literacy through Active plaY and environmental affordances in outdoor kindergarten settings: a multidimensional approach to Unveiling Potential (PLAY UP) - study protocol for a cluster-randomised trial. PG - e120976 LID - 10.1136/bmjopen-2026-120976 [doi] LID - e120976 AB - INTRODUCTION: Outdoor active play is essential for children's health, well-being and holistic development. However, there is a lack of high-quality evidence on effective sustainable and scalable interventions that leverage outdoor play and environmental affordances to promote physical literacy, including motor competence, physical activity, engagement and motivation for movement in early childhood. In particular, limited research has examined how outdoor kindergarten environments can be intentionally used and optimised to support diverse forms of active play through social and other potential affordances, nor how educators can be supported to facilitate such processes. The PLAY UP project aims to address this gap by investigating how a co-created, affordance-based intervention, developed in collaboration with children and supported by educator training, can enhance preschool children's engagement in active play and multidimensional development in outdoor kindergarten settings. METHODS AND ANALYSIS: This study describes the protocol of a cluster-randomised trial to be conducted in Portugal, involving three kindergartens and up to 215 preschool children, their educators and parents. The protocol includes an initial pilot phase (approximately 75 children from one kindergarten) to assess feasibility, acceptability and implementation procedures, followed by a main study phase with intervention and wait-list control clusters. The intervention comprises 15 sessions delivered in outdoor kindergarten settings. PLAY UP adopts a multidimensional and multimethod approach combining quantitative and qualitative methods. Outcomes related to physical literacy, including physical activity, motor competence, engagement, enjoyment and motivation for movement, are assessed using questionnaires, standardised tasks, accelerometry, Global Positioning System-based positioning technologies and systematic observations, complemented by interviews. Data will be analysed using cluster-aware statistical models and integrative mixed-methods approaches. ETHICS AND DISSEMINATION: This study has been approved by the Ethics Committee of the University of Evora (Ref. #24101). Written informed consent was obtained from parents or legal guardians, and all data will be handled confidentially in accordance with ethical and data protection standards. Study findings will be disseminated through open-access peer-reviewed publications, scientific conferences and knowledge-transfer activities targeting education professionals and relevant stakeholders. TRIAL REGISTRATION NUMBER: NCT07355179. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Almeida, Gabriela AU - Almeida G AUID- ORCID: 0000-0002-6716-2114 AD - Department of Sport and Health, University of Evora, School of Health and Human Development, Evora, Portugal gsna@uevora.pt. AD - Comprehensive Health Research Centre (CHRC), Universidade de Evora, Evora, Portugal. FAU - Goncalves, Bruno AU - Goncalves B AD - Department of Sport and Health, University of Evora, School of Health and Human Development, Evora, Portugal. AD - Comprehensive Health Research Centre (CHRC), Universidade de Evora, Evora, Portugal. FAU - Luz, Carlos AU - Luz C AD - Escola Superior de Educacao de Lisboa, Ci&DEI, Instituto Politecnico de Lisboa, Lisbon, Portugal. FAU - Galhardas, Luis AU - Galhardas L AD - Department of Sport and Health, University of Evora, School of Health and Human Development, Evora, Portugal. AD - Comprehensive Health Research Centre (CHRC), Universidade de Evora, Evora, Portugal. FAU - Bilton, Helen AU - Bilton H AD - Institute of Education, University of Reading, Reading, UK. FAU - Marmeleira, Jose AU - Marmeleira J AD - Department of Sport and Health, University of Evora, School of Health and Human Development, Evora, Portugal. AD - Comprehensive Health Research Centre (CHRC), Universidade de Evora, Evora, Portugal. LA - eng SI - ClinicalTrials.gov/NCT07355179 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260701 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Play and Playthings MH - Child, Preschool MH - *Exercise MH - Portugal MH - Randomized Controlled Trials as Topic MH - Schools MH - Research Design PMC - PMC13358333 OTO - NOTNLM OT - child education OT - health OT - intervention OT - physical fitness COIS- Competing interests: None declared. EDAT- 2026/07/02 04:10 MHDA- 2026/07/02 04:11 PMCR- 2026/07/01 CRDT- 2026/07/01 21:03 PHST- 2026/07/02 04:11 [medline] PHST- 2026/07/02 04:10 [pubmed] PHST- 2026/07/01 21:03 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - bmjopen-2026-120976 [pii] AID - 10.1136/bmjopen-2026-120976 [doi] PST - epublish SO - BMJ Open. 2026 Jul 1;16(7):e120976. doi: 10.1136/bmjopen-2026-120976. PMID- 42385346 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 1875-595X (Electronic) IS - 0020-6539 (Print) IS - 0020-6539 (Linking) VI - 76 IP - 5 DP - 2026 Oct TI - CBCT-Based Clinico-Radiomic Nomogram Predicting Preoperative Mandibular Third Molar Difficulty: Development/Validation. PG - 109714 LID - S0020-6539(26)00307-2 [pii] LID - 10.1016/j.identj.2026.109714 [doi] LID - 109714 AB - OBJECTIVE: This study aimed to develop and validate a clinico-radiomic nomogram, integrating Cone-Beam Computed Tomography (CBCT) radiomic features with clinical characteristics, to predict the difficulty of mandibular third molar (MTM) extraction. METHODS: A retrospective cohort of 600 patients undergoing MTM extraction was divided into training and validation sets. Radiomic features were extracted from preoperative CBCT images. The Least Absolute Shrinkage and Selection Operator (LASSO) method was used to select key features and build a radiomic score (Rad-score). Multivariable logistic regression identified independent clinical predictors. A final nomogram was established by combining the Rad-score and clinical factors. The model's performance was assessed for discrimination (AUC), calibration (Hosmer-Lemeshow test), and clinical utility (Decision Curve Analysis - DCA). RESULTS: Eleven robust features were selected to construct a radiomic signature. The Rad-score was significantly higher in the high-difficulty group (P < .001). Five independent predictors were identified: Age, BMI, Pell & Gregory classification, Root Curvature, and the Rad-score. The combined clinico-radiomic nomogram demonstrated superior predictive performance in both training (AUC = 0.892) and validation (AUC = 0.865) cohorts, significantly outperforming models based solely on clinical or radiomic factors alone. The model showed excellent calibration between predicted and observed probabilities and demonstrated substantial clinical net benefit via DCA. CONCLUSION: The novel CBCT-based clinico-radiomic nomogram provides a noninvasive, accurate, and visual tool for the preoperative stratification of MTM extraction difficulty. This facilitates more informed surgical planning and personalised patient counselling. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Xu, Mingchen AU - Xu M AD - Department of Emergency General, Wuxi Stomatological Hospital, Wuxi City, Jiangsu Province, China. FAU - Wu, Yijun AU - Wu Y AD - Department of Emergency General, Wuxi Stomatological Hospital, Wuxi City, Jiangsu Province, China. Electronic address: 15906176640@163.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20260701 PL - England TA - Int Dent J JT - International dental journal JID - 0374714 SB - IM MH - Humans MH - *Nomograms MH - *Cone-Beam Computed Tomography/methods MH - *Molar, Third/surgery/diagnostic imaging MH - Female MH - Radiomics MH - Retrospective Studies MH - Male MH - Adult MH - *Tooth Extraction/methods MH - Mandible/diagnostic imaging/surgery MH - Young Adult MH - *Tooth, Impacted/surgery/diagnostic imaging MH - Adolescent PMC - PMC13355169 OTO - NOTNLM OT - Cone-beam computed tomography OT - Mandibular third molar OT - Nomogram OT - Radiomics OT - Tooth extraction EDAT- 2026/07/02 04:10 MHDA- 2026/09/16 05:36 PMCR- 2026/07/01 CRDT- 2026/07/01 18:02 PHST- 2026/04/15 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/09/16 05:36 [medline] PHST- 2026/07/02 04:10 [pubmed] PHST- 2026/07/01 18:02 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - S0020-6539(26)00307-2 [pii] AID - 109714 [pii] AID - 10.1016/j.identj.2026.109714 [doi] PST - ppublish SO - Int Dent J. 2026 Oct;76(5):109714. doi: 10.1016/j.identj.2026.109714. Epub 2026 Jul 1. PMID- 42641033 STAT- Publisher PB - Canadian Agency for Drugs and Technologies in Health CTI - CADTH Reimbursement Reviews and Recommendations DP - 2026 Jul BTI - Evolocumab: Therapeutic area: Dyslipidemia and lipid disorders: Reimbursement Review AB - WHAT IS HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA? * Homozygous familial hypercholesterolemia (HoFH) is a rare and life-threatening genetic disorder characterized by defects in the low-density lipoprotein (LDL) receptor-mediated clearance of low-density lipoprotein cholesterol (LDL-C). HoFH manifests as extreme elevations in LDL-C with untreated levels typically exceeding 10 mmol/L, which predisposes patients to accelerated atherosclerotic cardiovascular disease and premature mortality, often as early as childhood or young adulthood. Other clinical manifestations of HoFH may include tendon or cutaneous xanthomas and premature atherosclerosis. * HoFH is generally estimated to occur in approximately 1 in 300,000 to 1 in 400,000 individuals worldwide from 2014 to 2024. In Canada, 38 to 100 cases are estimated based on the overall population of 38,000,000 in 2018 to 2019. Quebec was reported to have a higher prevalence of HoFH due to founder effects. * Genetic testing for HoFH comprises assessing for mutations in the LDLR, APOB, PCSK9, and LDLRAP1 genes. In Canada, genetic confirmation of HoFH can complement clinical diagnosis; however, availability is variable across the country. Due to the rarity of the disease and the likelihood that many existing patients may already have undergone genetic testing, minimal health system impacts are anticipated from a testing perspective to establish eligibility for treatment with evolocumab. WHAT ARE THE TREATMENT GOALS AND CURRENT TREATMENT OPTIONS FOR HOFH? * Treatment goals for HoFH include reducing LDL-C as much and as early as possible to delay or prevent premature cardiovascular events and improve long-term survival. * Standard therapy includes high-intensity statins and ezetimibe, but these are often insufficient for most patients with HoFH. Lipoprotein apheresis is effective but burdensome, requiring frequent procedures, specialized centres, and vascular access. * Additional lipid-lowering therapies may be used. Alirocumab can be effective in patients with HoFH and residual LDL receptor activity. Evinacumab, lomitapide, and mipomersen are potent lipid-lowering therapies specifically indicated for the treatment of HoFH, but their use may be limited by variable efficacy (i.e., depending on specific gene mutation), safety concerns, high cost, and restricted availability. WHAT IS EVOLOCUMAB AND WHY DID CANADA'S DRUG AGENCY CONDUCT THIS REVIEW? * Evolocumab is a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor that is administered by subcutaneous injection. Health Canada has approved evolocumab as an adjunct to diet and other LDL-C-lowering therapies (e.g., statins, ezetimibe) in patients aged 10 years and older with HoFH who require additional lowering of LDL-C. * At the request of the participating public drug programs, Canada's Drug Agency (CDA-AMC) reviewed evolocumab to inform a recommendation on whether it should be reimbursed for HoFH. HOW DID CDA-AMC EVALUATE EVOLOCUMAB? * CDA-AMC reviewed the clinical evidence on the beneficial and harmful effects of evolocumab and compared the costs of evolocumab versus other treatments used in Canada for HoFH. Background therapy (e.g., statins or ezetimibe) alone or with placebo as well as background therapy combined with evinacumab, alirocumab, or lomitapide were considered relevant treatments to compare with evolocumab when added to background therapy. * The clinical evidence was identified through systematic searches for available studies. * CDA-AMC identified equity and ethical considerations relevant to evolocumab and HoFH. * The review was also informed by 1 clinician group submission and 1 industry submission in response to our call for input, and by input from the participating public drug programs regarding issues that may impact their ability to implement a recommendation. * One endocrinologist and 2 cardiologists (1 adult and 1 pediatric cardiologist) were consulted as part of the review process. WHAT WERE THE FINDINGS? CLINICAL EVIDENCE: * CDA-AMC reviewed the following clinical evidence: o.. one randomized controlled phase III trial (the TESLA Part B trial) comparing evolocumab with placebo in 50 patients aged 13 to 57 years with HoFH; o.. three reports addressing evidence gaps in the included trial. * The TESLA Part B trial demonstrated that evolocumab significantly reduced LDL-C levels by 30.9% more than placebo at 12 weeks in patients with HoFH on stable background therapy (moderate certainty). This reduction was clinically meaningful. o.. LDL-C reductions were greatest in patients with at least 1 LDL receptor allele exhibiting defective function. Patients with 2 null alleles in the LDLR gene, resulting in little to not functional LDL receptor activity, showed minimal or no response. However, the observed subgroup effects were considered as having low or very low credibility. o.. Evolocumab reduces apolipoprotein B levels compared with placebo in patients with HoFH (moderate certainty). o.. This trial did not report cardiovascular outcomes or health-related quality of life. o.. Evolocumab can be described as well tolerated in the TESLA Part B trial, with no serious treatment-related adverse events, but the certainty of the evidence is very low due to the small sample size and the short duration of the study. * In the open-label, single-arm TAUSSIG study, evolocumab demonstrated an acceptable safety profile over a median of 4.1 years, with a cardiovascular event rate of 2.7% per patient-year in the overall study population, which included adult patients with HoFH (35% of participants) and severe heterozygous hypercholesterolemia. * The pooled analysis of 3 open-label studies in adolescents (aged 10 to 17 years) showed evolocumab was well tolerated, with no new safety signals. Residual LDL receptor activity did not reliably predict response. * One report on 2 case reports in children younger than 10 years reported LDL-C reductions of approximately 30% with good tolerability. However, this is insufficient evidence to support routine use in patients younger than 10 years. No comparative or long-term evidence exists for this population. * No studies were identified that compared the efficacy and safety of evolocumab with other relevant comparators (e.g., evinacumab, alirocumab, lomitapide) in this patient population. ECONOMIC EVIDENCE: * Reimbursing evolocumab for HoFH can reduce costs to the public drug programs with an unknown impact on clinical outcomes. LA - eng PT - Review PT - Book PL - Ottawa (ON) RF - 29 EDAT- 2026/07/01 00:00 CRDT- 2026/07/01 00:00 AID - NBK624206 [bookaccession] PMID- 42385311 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260804 IS - 1873-2380 (Electronic) IS - 0021-9290 (Linking) VI - 205 DP - 2026 Aug TI - Relationship between knee adduction moment and knee contact forces during walking and running with modified foot progression angles. PG - 113443 LID - S0021-9290(26)00298-8 [pii] LID - 10.1016/j.jbiomech.2026.113443 [doi] AB - Knee osteoarthritis (KOA) is a leading cause of disability, influenced by both systemic and mechanical factors. Gait modifications, such as toe-in (TIN) and toe-out (TOUT) foot progression angles, can alter knee adduction moment (KAM) and knee contact forces (KCF), but the task-specific relationship between these measures in walking and running remains unclear. Twenty healthy adults (age 18-35 years) were randomly assigned to walking or running groups. Participants completed natural and modified gait trials: TIN for walking and TOUT for running. KAM was calculated using a clinically feasible inverse-dynamics workflow in Visual3D, while musculoskeletal modelling in OpenSim estimated KCF. Correlations between KAM and medial KCF were assessed, and paired t-tests or linear mixed models examined the effects of gait modifications. During natural walking, early stance KAM was moderately correlated with medial KCF (r = 0.484; p = 0.011), but this relationship disappeared during TIN walking. Both KAM and medial KCF decreased with TIN walking (p < 0.040). In natural running, peak KAM did not correlate with medial KCF, whereas a strong correlation emerged during TOUT running (r = 0.619; p < 0.001). TOUT running increased medial KCF (p = 0.041) without altering KAM. The relationship between KAM and medial KCF is task- and modification-dependent. KAM is a reasonable surrogate for medial loading during natural walking but not during modified gait or running. Toe-in walking reduces both KAM and KCF, supporting its use in gait interventions for knee OA. Conversely, toe-out running can increase medial KCF despite unchanged KAM, highlighting gait modifications beneficial during walking may not translate to running. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Subasinghe Arachchige, Ransi S S AU - Subasinghe Arachchige RSS AD - Human Movement Laboratory, School of Health Sciences, Western Sydney University, New South Wales, Australia. FAU - Cheung, Roy T H AU - Cheung RTH AD - Human Movement Laboratory, School of Health Sciences, Western Sydney University, New South Wales, Australia; Translational Health Research Institute, Western Sydney University, New South Wales, Australia. Electronic address: Roy.Cheung@westernsydney.edu.au. LA - eng PT - Journal Article DEP - 20260630 PL - United States TA - J Biomech JT - Journal of biomechanics JID - 0157375 SB - IM MH - Humans MH - *Running/physiology MH - *Walking/physiology MH - Young Adult MH - *Knee Joint/physiology MH - Adult MH - Female MH - *Gait/physiology MH - Biomechanical Phenomena MH - Male MH - Adolescent MH - *Foot/physiology MH - Osteoarthritis, Knee/physiopathology OTO - NOTNLM OT - Gait modification OT - Joint loading OT - Knee osteoarthritis OT - Musculoskeletal modelling COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/01 22:34 MHDA- 2026/08/09 15:18 CRDT- 2026/07/01 18:01 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/09 15:18 [medline] PHST- 2026/07/01 22:34 [pubmed] PHST- 2026/07/01 18:01 [entrez] AID - S0021-9290(26)00298-8 [pii] AID - 10.1016/j.jbiomech.2026.113443 [doi] PST - ppublish SO - J Biomech. 2026 Aug;205:113443. doi: 10.1016/j.jbiomech.2026.113443. Epub 2026 Jun 30. PMID- 42385006 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1678-4464 (Electronic) IS - 0102-311X (Print) IS - 0102-311X (Linking) VI - 42 DP - 2026 TI - Feasibility of a generative AI chatbot to support breastfeeding in the Brazilian Unified National Health System. PG - e00117825 LID - S0102-311X2026000105046 [pii] LID - 10.1590/0102-311XEN117825 [doi] LID - e00117825 AB - This exploratory feasibility study aimed to evaluate the usability, user experience, and preliminary impacts of a generative language model-based chatbot (Lhia 2.0) on maternal self-efficacy and attitudes toward breastfeeding. A total of 13 mothers receiving care at the Human Milk Bank of the University Hospital of the Federal University of Maranhao interacted with the chatbot via WhatsApp over 15 days. The following instruments were applied before and after the use of Lhia 2.0: the Breastfeeding Self-Efficacy Scale - Short Form (BSES-SF) and the Iowa Infant Feeding Attitude Scale (IIFAS). The User Experience Questionnaire - Short Version (UEQ-S) was applied after the interaction. Results indicated excellent usability (pragmatic quality = +2.36; hedonic quality = +2.57) and high engagement (average interaction time = 92 minutes). Statistically significant improvements were observed in BSES-SF (mean difference = 3.00; p = 0.042; Cohen's d = 0.778) and in IIFAS (mean difference = 3.50; p = 0.021; Cohen's d = 0.778). The results indicated high acceptance among mothers, with notable user engagement, excellent perceived usability, and positive effects on confidence and attitudes toward breastfeeding. Based on these findings, Lhia 2.0 is considered a feasible and promising tool for integration into breastfeeding promotion strategies, particularly within the context of the Brazilian Unified National Health System. FAU - Araujo Neto, Ari Pereira de AU - Araujo Neto AP AUID- ORCID: 0000-0001-6903-4127 AD - Universidade Federal do Delta do Parnaiba, Parnaiba, Brasil. AD - Hospital Universitario da Universidade Federal do Maranhao, Sao Luis, Brasil. FAU - Pinto, Giovanny Reboucas AU - Pinto GR AUID- ORCID: 0000-0001-9110-1840 AD - Universidade Federal do Delta do Parnaiba, Parnaiba, Brasil. FAU - Oliveira, Adonias Caetano de AU - Oliveira AC AUID- ORCID: 0000-0002-5643-2916 AD - Universidade Federal do Delta do Parnaiba, Parnaiba, Brasil. AD - Instituto Federal de Educacao, Ciencia e Tecnologia do Ceara, Tiangua, Brasil. FAU - Chagas, Simone Nunes Leal AU - Chagas SNL AUID- ORCID: 0000-0002-9536-9315 AD - Hospital Universitario da Universidade Federal do Maranhao, Sao Luis, Brasil. FAU - Conceicao, Francilidia Oliveira Vitorino de Assuncao AU - Conceicao FOVA AUID- ORCID: 0000-0002-0079-7502 AD - Universidade Federal do Maranhao, Sao Luis, Brasil. FAU - Teles, Ariel Soares AU - Teles AS AUID- ORCID: 0000-0002-0840-3870 AD - Programa de Pos-graduacao em Biotecnologia, Universidade Federal do Delta do Parnaiba, Parnaiba, Brasil. LA - eng PT - Journal Article DEP - 20260626 PL - Brazil TA - Cad Saude Publica JT - Cadernos de saude publica JID - 8901573 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - Brazil MH - Adult MH - Feasibility Studies MH - Surveys and Questionnaires MH - Self Efficacy MH - Generative Artificial Intelligence MH - *Mothers/psychology MH - National Health Programs MH - Young Adult PMC - PMC13313153 EDAT- 2026/07/01 18:33 MHDA- 2026/07/01 18:34 PMCR- 2026/06/26 CRDT- 2026/07/01 15:43 PHST- 2025/06/16 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/07/01 18:34 [medline] PHST- 2026/07/01 18:33 [pubmed] PHST- 2026/07/01 15:43 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - S0102-311X2026000105046 [pii] AID - 10.1590/0102-311XEN117825 [doi] PST - epublish SO - Cad Saude Publica. 2026 Jun 26;42:e00117825. doi: 10.1590/0102-311XEN117825. eCollection 2026. PMID- 42384157 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260813 IS - 1573-3521 (Electronic) IS - 0160-7715 (Print) IS - 0160-7715 (Linking) VI - 49 IP - 4 DP - 2026 Aug TI - Ecological predictors of daily dietary intake in black adolescents with overweight and obesity in the families improving together (FIT) for weight loss trial. PG - 631-643 LID - 10.1007/s10865-026-00686-y [doi] AB - Healthful eating habits (i.e., increased fruit and vegetable and decreased hyperpalatable energy-dense food and drink consumption) are important for preventing chronic disease risk (e.g., obesity) and improving overall health in Black adolescents.This study examines the intrapersonal, interpersonal, and environmental factors associated with daily dietary intake in Black adolescents with overweight and obesity. Baseline data were analyzed from 241 Black parent-adolescent dyads who participated in the Families Improving Together (FIT) for Weight Loss trial (Adolescent: Mage = 12.8 years, SD = 1.8; 63% female; MBMI% = 96.6, SD = 4.3). Intrapersonal factors included dietary motivation. Interpersonal factors included social support for diet from family. Environmental factors included access to food in the home. Dietary outcomes were measured using validated adolescent self-reported surveys. Separate multiple linear regressions revealed several associations between ecological factors and daily food intake. Greater access to more-healthful foods was associated with increased daily vegetable intake (beta = 0.18, SE = 0.08, p < .05), whereas greater access to less-healthful foods was associated with increased daily fruit intake (beta = 0.24, SE = 0.08, p < .05). Greater access to less-healthful foods was associated with increased daily energy-dense food intake (beta = 0.75, SE = 0.10, p < .001), whereas increased self-reported dietary motivation was associated with decreased daily energy-dense food intake (beta = -0.24, SE = 0.10, p < .05). Greater access to less-healthful foods (beta = 1.48, SE = 0.23, p < .001) and higher adolescent BMI (beta = 0.84, SE = 0.40, p < .05) was also associated with increased sugar-sweetened beverage consumption. These findings suggest that access to more-healthful foods is associated with greater vegetable intake, while restricting access to less-healthful foods and increased motivation for more healthful eating were associated with lower sugar-sweetened beverage and energy-dense food consumption among Black adolescents. These findings may inform future health promotion programs across various ecological levels of dietary behaviors in Black youth with overweight and obesity. CI - (c) 2026. The Author(s). FAU - White, Taylor R AU - White TR AUID- ORCID: 0000-0001-6540-0994 AD - Department of Psychology, University of South Carolina, Columbia, SC, USA. trw9@email.sc.edu. FAU - Wilson, Dawn K AU - Wilson DK AD - Department of Psychology, University of South Carolina, Columbia, SC, USA. FAU - Tucker, Sonali AU - Tucker S AD - Department of Psychology, University of South Carolina, Columbia, SC, USA. FAU - Sweeney, Allison AU - Sweeney A AD - School of Nursing, University of South Carolina, Columbia, SC, USA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260701 PL - United States TA - J Behav Med JT - Journal of behavioral medicine JID - 7807105 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Black or African American/psychology MH - Diet MH - Diet, Healthy MH - *Feeding Behavior/ethnology/psychology MH - Motivation MH - *Pediatric Obesity/ethnology/psychology/therapy MH - Social Support MH - Weight Loss PMC - PMC13385267 OTO - NOTNLM OT - Adolescent OT - Black or African American OT - Diet OT - Ecological OT - Food availability OT - Obesity COIS- Declarations. Conflict of interest: The authors declare no conflicts of interest. Ethical approval: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of the University of South Carolina (Protocol Code: Pro00016136, approved January 23, 2013). Consent to participate: Informed consent and assent were obtained from all subjects involved in the study. Trial registration: The FIT trial was registered on January 23, 2013, on ClinicalTrials.gov NCT01796067. EDAT- 2026/07/01 16:11 MHDA- 2026/07/21 06:34 PMCR- 2026/07/01 CRDT- 2026/07/01 11:06 PHST- 2025/12/12 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/07/21 06:34 [medline] PHST- 2026/07/01 16:11 [pubmed] PHST- 2026/07/01 11:06 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.1007/s10865-026-00686-y [pii] AID - 686 [pii] AID - 10.1007/s10865-026-00686-y [doi] PST - ppublish SO - J Behav Med. 2026 Aug;49(4):631-643. doi: 10.1007/s10865-026-00686-y. Epub 2026 Jul 1. PMID- 42383864 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260805 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 8 DP - 2026 Aug 24 TI - Evaluation of the relationship between HOMA-IR, triglyceride-glucose index, and triglyceride/HDL-cholesterol ratio with the presence and severity of hepatic steatosis in children with obesity. PG - 741-748 LID - 10.1515/jpem-2025-0738 [doi] AB - OBJECTIVES: Hepatic steatosis (HS) represents one of the most frequent metabolic complications of pediatric obesity and is closely linked with insulin resistance (IR). Although the homeostatic model assessment for insulin resistance (HOMA-IR) is widely used, lipid-derived indices such as the triglyceride-glucose (TyG) index and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio have recently emerged as simple IR surrogates. Data comparing these indices with HS severity in children remain limited. METHODS: This single-center retrospective study included 462 children aged 6-18 years with overweight or obesity who were evaluated between October 2023 and December 2024. Anthropometry, biochemical data, and ultrasonographic HS grading were obtained from medical records. HOMA-IR, TyG, and TG/HDL-C indices were calculated, and their associations with HS presence and severity were analyzed using correlation and multivariable regression models. RESULTS: HS was identified in 53.5 % of participants (grade 1: 29.9 %, grade 2: 16.6 %, grade 3: 6.0 %). Children with HS demonstrated significantly higher HOMA-IR, TyG index, and TG/HDL-C ratio compared with those without HS (all p<0.001). HOMA-IR increased progressively with HS grade (p<0.05), whereas TyG and TG/HDL-C did not display a significant gradient. Logistic regression confirmed that HOMA-IR was independently associated with HS severity (beta=0.261; 95 % CI: 0.030-0.078; p<0.001), while TyG and TG/HDL-C were not. ALT levels rose significantly with HS grade, whereas AST showed no severity-related pattern. CONCLUSIONS: HOMA-IR remains the strongest metabolic predictor of hepatic steatosis severity in pediatric obesity. Although TyG and TG/HDL-C reliably differentiate HS presence, they do not independently estimate HS progression. Lipid-derived markers may support non-insulin-based screening; however, HOMA-IR should be prioritized when stratifying steatosis risk. CI - (c) 2026 Walter de Gruyter GmbH, Berlin/Boston. FAU - Turan, Benay AU - Turan B AUID- ORCID: 0000-0002-6947-6782 AD - Izmir City Hospital, Pediatric Endocrinology Clinic, Izmir, Turkiye. FAU - Arslan, Emrullah AU - Arslan E AUID- ORCID: 0000-0003-3613-8119 AD - Izmir City Hospital, Pediatric Endocrinology Clinic, Izmir, Turkiye. FAU - Er, Eren AU - Er E AUID- ORCID: 0000-0003-4770-0365 AD - Izmir City Hospital, Pediatric Endocrinology Clinic, Izmir, Turkiye. FAU - Dundar, Bumin Nuri AU - Dundar BN AUID- ORCID: 0000-0002-7506-061X AD - Izmir Katip Celebi University, Pediatric Endocrinology Department, Izmir, Turkiye. LA - eng PT - Journal Article DEP - 20260702 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 RN - 0 (Triglycerides) RN - 0 (Cholesterol, HDL) RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - Male MH - *Insulin Resistance MH - Female MH - *Fatty Liver/etiology/blood/diagnosis/pathology MH - *Triglycerides/blood MH - Retrospective Studies MH - Adolescent MH - *Cholesterol, HDL/blood MH - *Blood Glucose/analysis MH - *Pediatric Obesity/complications/blood MH - Severity of Illness Index MH - *Biomarkers/blood MH - Follow-Up Studies MH - Prognosis MH - Body Mass Index OTO - NOTNLM OT - HOMA-IR OT - TG/HDL-C ratio OT - hepatic steatosis OT - insulin resistance OT - pediatric obesity OT - tyg index EDAT- 2026/07/01 12:47 MHDA- 2026/08/05 17:37 CRDT- 2026/07/01 10:03 PHST- 2025/12/24 00:00 [received] PHST- 2026/05/17 00:00 [accepted] PHST- 2026/08/05 17:37 [medline] PHST- 2026/07/01 12:47 [pubmed] PHST- 2026/07/01 10:03 [entrez] AID - jpem-2025-0738 [pii] AID - 10.1515/jpem-2025-0738 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 Jul 2;39(8):741-748. doi: 10.1515/jpem-2025-0738. Print 2026 Aug 24. PMID- 42383232 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2590-1613 (Electronic) IS - 2590-1613 (Linking) VI - 31 DP - 2026 Sep TI - Reproductive potential in classical galactosemia: A case series based perspective. PG - 100470 LID - 10.1016/j.eurox.2026.100470 [doi] LID - 100470 AB - INTRODUCTION: Classical galactosemia (CG), caused by galactose-1-phosphate uridylyltransferase (GALT) enzyme deficiency, is associated with premature ovarian insufficiency (POI) and subfertility. The last years, a counseling paradigm shift has been advocated with emphasis on subfertility instead of infertility because spontaneous pregnancy can occur. CASE PRESENTATIONS: We describe two women (aged 26 and 30 years) with genetically confirmed CG and POI, who conceived spontaneously. Both adhered to lifelong galactose-restricted diet and had regular endocrine monitoring. Their pregnancies were uncomplicated and each delivered a healthy infant at term. CONCLUSIONS: These cases are in line with the counseling paradigm shift, with natural conception being possible in CG. Reproductive counselling of girls and women with CG should entail fertility preservation and spontaneous pregnancy. In case of desired pregnancy, a period of two years to attempt conceiving should be advised. AMH is not a reliable prognostic parameter for predicting the reproductive potential in CG. CI - (c) 2026 The Authors. FAU - Panis, Bianca AU - Panis B AD - Department of Pediatrics, Genetic Metabolic Diseases, Mosakids hospital, Maastricht University Medical Centre, Maastricht, the Netherlands. FAU - van Golde, Ron Jt AU - van Golde RJ AD - Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, the Netherlands. AD - GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands. FAU - Brouwers, Martijn Cgj AU - Brouwers MC AD - Department of Endocrinology and Metabolic Diseases, Maastricht University Medical Centre, Maastricht, the Netherlands. AD - Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6200 MD, the Netherlands. FAU - Korver-Keularts, Irene Mlw AU - Korver-Keularts IM AD - Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, the Netherlands. AD - Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands. FAU - Noga, Marek J AU - Noga MJ AD - Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, the Netherlands. FAU - Rubio-Gozalbo, M Estela AU - Rubio-Gozalbo ME AD - Department of Pediatrics, Genetic Metabolic Diseases, Mosakids hospital, Maastricht University Medical Centre, Maastricht, the Netherlands. AD - GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands. AD - Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, the Netherlands. LA - eng PT - Journal Article DEP - 20260617 PL - Netherlands TA - Eur J Obstet Gynecol Reprod Biol X JT - European journal of obstetrics & gynecology and reproductive biology: X JID - 101750520 PMC - PMC13315757 OTO - NOTNLM OT - Case report OT - Classical galactosemia OT - Fertility counselling OT - Premature ovarian insufficiency OT - Spontaneous pregnancy COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/06/17 CRDT- 2026/07/01 05:22 PHST- 2026/03/01 00:00 [received] PHST- 2026/04/15 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 05:22 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - S2590-1613(26)00027-X [pii] AID - 100470 [pii] AID - 10.1016/j.eurox.2026.100470 [doi] PST - epublish SO - Eur J Obstet Gynecol Reprod Biol X. 2026 Jun 17;31:100470. doi: 10.1016/j.eurox.2026.100470. eCollection 2026 Sep. PMID- 42382932 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2094-9278 (Electronic) IS - 0001-6071 (Print) IS - 0001-6071 (Linking) VI - 60 IP - 10 DP - 2026 TI - Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Prenatal Disorders. PG - 210-227 LID - 10.47895/amp.v60i10.13595 [doi] AB - BACKGROUND: The Philippine Guidelines on Periodic Health Examination (PHEX) support the Universal Health Care Act by providing guidance on quality, accessible, and affordable screening services for Filipinos. Conditions that develop in the prenatal period are a major cause of neonatal deaths in the Philippines and account for 14% of deaths in children under five. OBJECTIVES: This guideline aims to provide evidence-based recommendations for screening prenatal disorders among asymptomatic, pregnant Filipino women. It also aims to equip general practitioners, obstetricsgynecology specialists, allied health professionals, patients, policymakers, regulatory agencies, and healthcare institutions with tools and guidance that facilitate informed, evidence-based healthcare decisions for pregnant women. METHODS: The development of this CPG followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to CPG development recommended in the Department of Health (DOH) Manual. Recommendations were finalized using the Evidence-to-Decision (EtD) framework. Evidence Review Experts conducted a systematic literature search and critically appraised recent local and international clinical guidelines. When necessary, they conducted de novo systematic reviews. Information on the benefits and harms of screening, cost-effectiveness, patient values and preferences, acceptability, feasibility, and its impact on equity was obtained. A multisectoral consensus panel reviewed the evidence and developed recommendations. A user-friendly web application and engagement with stakeholders for promotion and implementation were among the dissemination strategies. Experts conducted an external review to provide feedback on the methodology and recommendations. RESULTS: Eleven recommendations for different screening strategies to improve the health outcomes of pregnant women and neonates were developed. This CPG contains recommendations for the screening for maternal thyroid disease, gestational diabetes mellitus, group B Streptococcus infection, fetal aneuploidy, risk for preeclampsia, iron deficiency anemia, and undernutrition, and conducting cervical length measurements, first-trimester ultrasound, and second-trimester ultrasound. CONCLUSION: This CPG provides 11 evidence-based recommendations. Applicability in the local setting was carefully considered through the involvement of different stakeholders. The recommendations herein shall hold until new evidence on screening, diagnosing, or managing various risk factors and diseases emerges, or contingencies dictate updating this CPG. This guideline will be updated after three (3) years. CI - (c) 2026 Acta Medica Philippina. FAU - Germar, Maria Julieta Corazon V AU - Germar MJCV AD - College of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Palileo-Villanueva, Lia M AU - Palileo-Villanueva LM AD - College of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Suplido, Sherri Ann L AU - Suplido SAL AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Villaluz, Ma Susan B AU - Villaluz MSB AD - Cebu Puericulture Center and Maternity House, Inc., Cebu, Philippines. FAU - Gianan, Mike Justin A AU - Gianan MJA AD - Department of Family and Community Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Sy, Endrik H AU - Sy EH AD - Baguio General Hospital and Medical Center, Benguet, Philippines. FAU - Castillo, Betha Fe M AU - Castillo BFM AD - Dagupan Doctors Villaflor Memorial Hospital, Pangasinan, Philippines. FAU - Boransing, Potre Mairasna P AU - Boransing PMP AD - Amai Pakpak Medical Center, Marawi City, Philippines. FAU - De Peralta-Yambao, Helen B AU - De Peralta-Yambao HB AD - Cotabato Regional and Medical Center, Cotabato City, Philippines. FAU - Cacas, Maria Theresa G AU - Cacas MTG AD - University of the East Ramon Magsaysay Medical Center, Quezon City, Philippines. FAU - Besa, John Jefferson V AU - Besa JJV AD - College of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Masamayor, Ella Mae I AU - Masamayor EMI AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Malijan, Greco Mark B AU - Malijan GMB AD - Clinical Trial Service and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. FAU - Villanueva, Cary Amiel G AU - Villanueva CAG AD - Division of Pulmonary Medicine, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Villafuerte, Andrew Rufino C AU - Villafuerte ARC AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Cerrado, Johannes Paolo B AU - Cerrado JPB AD - Policy and Practice Research Group, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. FAU - Cruz, Marie Gene D AU - Cruz MGD AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - De Castro, Lea Roselle O AU - De Castro LRO AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Sucaldito, Ma Sergia Fatima C AU - Sucaldito MSFC AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Yoshida, Alfonso Syoei R AU - Yoshida ASR AD - AMOSUP Seamen's Hospital - Manila, Manila, Philippines. FAU - Geroy, Lester Sam A AU - Geroy LSA AD - Philippine Society of Public Health Physicians (PSPHP), Inc., Paranaque City, Philippines. FAU - Estrada, Elvie Udaundo AU - Estrada EU AD - Integrated Midwives Association of the Philippines, Pangasinan, Philippines. FAU - Garcia, Daisy Evangeline C AU - Garcia DEC AD - Ilocos Training and Regional Medical Center, La Union, Philippines. FAU - Sta Ana, Ferdinand B AU - Sta Ana FB AD - Municipal Health Office, Narra, Palawan, Philippines. FAU - Elises-Molon, Kristine Therese R AU - Elises-Molon KTR AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Silverio-Fernando, Karla Kristine AU - Silverio-Fernando KK AD - Manila Doctors Hospital, Manila, Philippines. FAU - Velayo, Clarissa L AU - Velayo CL AD - College of Medicine, University of the Philippines Manila, Manila, Philippines. AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - David-Bustamante, Lara Marie AU - David-Bustamante LM AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Diosana, Jo-Ann L AU - Diosana JL AD - Action for Economic Reforms (AER), Quezon City, Philippines. FAU - Silvestre, Maria Asuncion A AU - Silvestre MAA AD - Kalusugan ng Mag-Ina, Inc., (KMI), Quezon City, Philippines. FAU - Infantado-Alejandro, Myzelle Anne J AU - Infantado-Alejandro MAJ AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. AD - De La Salle Medical and Health Sciences Institute, Dasmarinas City, Cavite, Philippines. CN - Philippine Periodic Health Examination Task Force on Prenatal Disorders LA - eng PT - Journal Article DEP - 20260530 PL - Philippines TA - Acta Med Philipp JT - Acta medica Philippina JID - 0312677 PMC - PMC13316254 OTO - NOTNLM OT - antenatal care OT - maternal health OT - neonatal health OT - prenatal clinical practice guidelines OT - screening COIS- All authors declared no conflicts of interest. EDAT- 2026/07/01 06:33 MHDA- 2026/07/01 06:34 PMCR- 2026/05/30 CRDT- 2026/07/01 05:18 PHST- 2026/07/01 06:34 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 05:18 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - AMP-60-10-13595 [pii] AID - 10.47895/amp.v60i10.13595 [doi] PST - epublish SO - Acta Med Philipp. 2026 May 30;60(10):210-227. doi: 10.47895/amp.v60i10.13595. eCollection 2026. PMID- 42382929 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2094-9278 (Electronic) IS - 0001-6071 (Print) IS - 0001-6071 (Linking) VI - 60 IP - 10 DP - 2026 TI - 2021 Clinical Practice Guidelines on Periodic Health Examination. PG - 7-27 LID - 10.47895/amp.v60i10.12061 [doi] AB - BACKGROUND AND OBJECTIVE: The first Philippine Guidelines on Periodic Health Examination (PHEX) provided evidence-based recommendations for prevention strategies in the Philippines, published in 2004. This 2021 clinical practice guideline (CPG) on PHEX aimed to update the previous PHEX recommendations to align with the implementation of the Universal Health Care Act. This CPG aimed to guide primary care providers, specialists, patients, and the general public and provide recommendations for safe, accessible, and cost-effective screening practices. METHODS: We followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, including the GRADE Adolopment and Evidence-to-Decision framework (EtD). A multisectoral panel developed the recommendations by a formal consensus method upon evaluation of the evidence on benefits and harms, cost-effectiveness, patient values and preferences, acceptability, feasibility, and impact on equity. A conflicts of interest (COI) committee reviewed, evaluated, and managed the potential or declared conflicts of interest of this CPG's Task Force members. RESULTS: The 2020 PHEX CPG had 23 recommendation statements. Strong recommendations were made to screen for the following conditions 1) Hypertension, 2) Type 2 Diabetes Mellitus using fasting blood sugar, 3) Adult obesity using Body Mass Index (BMI), 4) Unhealthy alcohol use in adults, 5) Tobacco smoking, 6) Colorectal cancer, and 7) Cervical cancer.Weak recommendations were developed to screen for the following: 1) Lipid disorder among adults with cardiovascular risk factors, 2) Type 2 DM using HBA1C, 3) Acute malnutrition in children, 4) Unhealthy alcohol use in adolescents, 5) High-risk sexual behavior, 6) Depression, and 7) Pulmonary Tuberculosis using chest X-ray.On the other hand, strong recommendations were also made AGAINST screening for the following: 1) Developmental delay using developmental screening tools, 2) Coronary artery disease using ECG, and 3) Chronic Kidney Disease (CKD) using serum creatinine.Weak recommendations were also formulated AGAINST screening for the following: 1) Anemia using hemoglobin and/or hematocrit, 2) CKD using urinalysis, and 3) Lung cancer using chest X-ray. CONCLUSION: This guideline encourages adherence without restricting clinical judgment or patient-specific considerations. It also informs payers and policymakers without serving as the sole basis for financial or legal decisions. The strong recommendations in this CPG can be used as quality-of-care indicators when evaluating primary care programs. The recommendation statements will be updated at least every three years or as new evidence emerges. CI - (c) 2026 Acta Medica Philippina. FAU - Cabaluna, Ian Theodore G AU - Cabaluna ITG AD - Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila, Philippines. FAU - Sulit, Maria Vanessa V AU - Sulit MVV AD - Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila, Philippines. FAU - Infantado-Alejandro, Myzelle Anne J AU - Infantado-Alejandro MAJ AD - De La Salle Medical and Health Sciences Institute, Cavite, Philippines. FAU - Bayona, Howell Henrian G AU - Bayona HHG AD - Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila, Philippines. FAU - Dans, Leonila F AU - Dans LF AD - Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines. CN - 2021 Philippine Periodic Health Examination Guideline Task Force LA - eng PT - Journal Article DEP - 20260530 PL - Philippines TA - Acta Med Philipp JT - Acta medica Philippina JID - 0312677 PMC - PMC13316251 OTO - NOTNLM OT - guidelines OT - periodic health examination OT - prevention OT - screening COIS- All authors declared no conflicts of interest. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/05/30 CRDT- 2026/07/01 05:18 PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 05:18 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - AMP-60-10-12061 [pii] AID - 10.47895/amp.v60i10.12061 [doi] PST - epublish SO - Acta Med Philipp. 2026 May 30;60(10):7-27. doi: 10.47895/amp.v60i10.12061. eCollection 2026. PMID- 42382928 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2094-9278 (Electronic) IS - 0001-6071 (Print) IS - 0001-6071 (Linking) VI - 60 IP - 10 DP - 2026 TI - Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Renal, Metabolic, Nutritional, and Endocrine Disorders. PG - 196-209 LID - 10.47895/amp.v60i10.11674 [doi] AB - BACKGROUND AND OBJECTIVE: Renal, metabolic, nutritional, and endocrine disorders significantly affect Filipinos due to the resulting mortality, cardiovascular outcomes, and negative impact on quality of life. Screening for these disorders may lead to earlier detection and management of the disease, with subsequent improvement of clinical outcomes if early therapeutic options are available. This must be balanced with potential harms resulting from mislabeling and the adverse effects of treatment. The objective of this clinical practice guideline (CPG) is to provide recommendations to optimize patient care on screening for renal, metabolic, nutritional, and endocrine disorders among asymptomatic, apparently healthy Filipinos. METHODS: We followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to CPG development recommended in the Department of Health Manual. The process included 1) generation of critical questions and critical outcomes, 2) retrieval of current evidence, 3) synthesis and assessment of the evidence base for these critical questions, 4) formulation of draft recommendations, 5) convening of a multisectoral stakeholder panel that evaluated the evidence base and considered feasibility, values, and preferences in formulating recommendations, and 6) planning for dissemination, implementation, impact evaluation, and updating. We performed a systematic synthesis of evidence to address screening for high climacteric syndrome, hypocalcemia or hypercalcemia, prediabetes, chronic kidney disease, hyperuricemia, malnutrition, nutritional anemia, among asymptomatic, apparently healthy adult Filipinos, and sexual maturity among asymptomatic, apparently healthy adolescent Filipinos. RESULTS: After the presentation of the evidence synthesis and deliberation of the consensus panelists, this CPG provides 18 recommendation statements for the eight conditions. These statement recommendations serve as guides for the primary care physicians in their screening for the identified renal, metabolic, nutritional, and endocrine disorders. The CPG recommends AGAINST screening for high climacteric syndrome among asymptomatic, apparently healthy women aged 45-55 years using hormonal tests. Moreover, the guideline DOES NOT recommend the use of serum calcium, electrocardiogram, or bone mineral density in screening for hypocalcemia or hypercalcemia; estimated glomerular filtration rate, urine albumin concentration, urine albumin-creatinine ratio, and kidney ultrasonography in screening for chronic kidney disease; mid-upper arm circumference in screening for malnutrition; and, serum uric acid in screening for hyperuricemia for apparently healthy, asymptomatic adults. Routine assessment for sexual maturity among asymptomatic adolescents is also NOT recommended. However, the guideline recommends using fasting plasma glucose and hemoglobin A1C in screening for prediabetes and type 2 diabetes mellitus; waist circumference, waist-hip ratio, and body mass index in screening for malnutrition; and hemoglobin and red blood cell parameters in screening for nutritional anemia. CONCLUSION: The CPG for the Periodic Health Examination, a joint project of the Department of Health and the National Institutes of Health, addressed selected renal, metabolic, nutritional, and endocrine conditions and provided recommendations for their screening. The statements are made to guide the primary care physicians in the screening of identified renal, metabolic, nutritional, and endocrine disorders. These recommendations will be updated after three years or until new evidence arises. CI - (c) 2026 Acta Medica Philippina. FAU - Paz-Pacheco, Elizabeth AU - Paz-Pacheco E AD - Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Oliva, Raymond V AU - Oliva RV AD - Division of Hypertension, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Acuin, Cecilia S AU - Acuin CS AD - Institute of Human Nutrition and Food, University of the Philippines Los Banos, Laguna, Philippines. FAU - Tan, Rey Jaime M AU - Tan RJM AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Sarsagat, Jim Paulo D AU - Sarsagat JPD AD - Allied Care Experts Medical Center Palawan, Palawan, Philippines. CN - Philippine Periodic Health Examination Task Force on Screening for Renal, Metabolic, Nutrition, and Endocrine Disorders LA - eng PT - Journal Article DEP - 20260530 PL - Philippines TA - Acta Med Philipp JT - Acta medica Philippina JID - 0312677 PMC - PMC13316249 OTO - NOTNLM OT - anemia OT - chronic kidney diseases OT - climacteric OT - guidelines OT - hypercalcemia OT - hyperuricemia OT - hypocalcemia OT - malnutrition OT - menopause OT - obesity OT - prediabetes OT - sexual maturation COIS- All authors declared no conflicts of interest. EDAT- 2026/07/01 06:33 MHDA- 2026/07/01 06:34 PMCR- 2026/05/30 CRDT- 2026/07/01 05:18 PHST- 2026/07/01 06:34 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 05:18 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - AMP-60-10-11674 [pii] AID - 10.47895/amp.v60i10.11674 [doi] PST - epublish SO - Acta Med Philipp. 2026 May 30;60(10):196-209. doi: 10.47895/amp.v60i10.11674. eCollection 2026. PMID- 42382901 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - Development of a Nomogram for Peak Nasal Inspiratory Flow Among Indian Children: A Hospital-Based Observational Study. PG - e109948 LID - 10.7759/cureus.109948 [doi] LID - e109948 AB - OBJECTIVE: This study aimed to develop a nomogram for the peak nasal inspiratory flow (PNIF) meter among Indian children and to determine the cutoff value of peak nasal inspiratory flow to detect allergic rhinitis and the blocker variety, as well as to look for differences in PNIF value among age groups. METHODS: A cross-sectional study was conducted in the pediatric outpatient department of a tertiary hospital among children aged six to 17 years. The PNIF data were obtained along with demographic variables. Children were diagnosed with allergic rhinitis, with or without blockage symptoms, according to the Allergic Rhinitis and its Impact on Asthma (ARIA) classification. A total of 573 children were included after applying the exclusion criteria. Data analysis was done using SPSS Statistics version 25 (IBM Corp., Armonk, NY, USA) and Dxt version 1.0 (Biostatistics Resource and Training Centre, Christian Medical College Vellore, TN, IND). RESULTS: The mean PNIF value of all age groups was 67.95 L/min (standard deviation 13.46). The PNIF has a statistically significant but weak correlation with age and a statistically significant difference between age groups. Cutoff values for both allergic rhinitis and blocker varieties were 65 L/min, with varying sensitivity and specificity across age groups. Multiple linear regression analysis derived the equation for PNIF = 53.061 + (1.689 x age) + (1.312 x gender) + (-0.015 x BMI). CONCLUSION: The PNIF with set cutoff values can be used to diagnose allergic rhinitis and the blocker variety in Indian children. It can be used as a diagnostic tool to determine allergic rhinitis with modest diagnostic accuracy in the six to nine-year and 13 to 17-year age groups. For children more than 10 years of age, PNIF demonstrates clinical utility in determining the obstructive nasal phenotype. CI - Copyright (c) 2026, Mitra et al. FAU - Mitra, Samya AU - Mitra S AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Mishra, Nihar R AU - Mishra NR AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Singh, Ritesh AU - Singh R AD - Community and Family Medicine, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Sarkar, Subhankar AU - Sarkar S AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Das, Aditi AU - Das A AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Bhunia, Niladri S AU - Bhunia NS AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Bhowmick, Rohit AU - Bhowmick R AD - Pediatric Critical Care Medicine, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Sonowal, Rimjhim AU - Sonowal R AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. LA - eng PT - Journal Article DEP - 20260530 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13315212 OTO - NOTNLM OT - allergic rhinitis OT - clinical nomogram OT - indian children OT - peak nasal inspiratory flow OT - pediatric allergy COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee of All India Institute of Medical Sciences (AIIMS), Kalyani issued approval IEC/AIIMS/Kalyani/Meeting/2023/096. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/05/30 CRDT- 2026/07/01 05:18 PHST- 2026/05/30 00:00 [accepted] PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 05:18 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - 10.7759/cureus.109948 [doi] PST - epublish SO - Cureus. 2026 May 30;18(5):e109948. doi: 10.7759/cureus.109948. eCollection 2026 May. PMID- 42382799 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2590-1575 (Electronic) IS - 2590-1575 (Linking) VI - 37 DP - 2026 Jul TI - Simultaneous determination of vitamin A and E in infant formula using a modified QuEChERS approach coupled with ultrahigh-performance liquid chromatography-diode array detection. PG - 104131 LID - 10.1016/j.fochx.2026.104131 [doi] LID - 104131 AB - The simultaneous determination of vitamin A and E vitamers in complex matrices presents a significant analytical challenge. To address this, we validated a straightforward method based on a QuEChERS pretreatment coupled with ultrahigh-performance liquid chromatography and diode array detection (QuEChERS-UPLC-DAD). The modified QuEChERS pretreatment procedure integrates saponification and extraction processes into a single step, enabling efficient phase separation, reducing analysis time, and eliminating the need for a salting-out step. Notably, this approach simultaneously accomplishes a recovery of 83.2% to 100.5%, a relative standard deviation of less than 4.6%. The accuracy of the proposed QuEChERS-UPLC-DAD method was confirmed through comparison with a UPLC-IDMS/MS method and analysis of a commercial certified reference material (NIST SRM 1869). Importantly, the approach was successfully applied to analyze various complex dairy products, including infant formula, milk, yogurt, and dairy beverages. Therefore, QuEChERS-UPLC-DAD approach is well-suited for routine quality control and nutritional assessment. CI - (c) 2026 The Authors. FAU - Zhao, Xiaotong AU - Zhao X AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. AD - College of Chemistry, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. FAU - Li, Xiaomin AU - Li X AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. FAU - Luo, Shuangxia AU - Luo S AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. AD - College of Chemistry, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. FAU - Zhang, Xuanping AU - Zhang X AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. AD - College of Chemistry, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. FAU - Zhang, Qinghe AU - Zhang Q AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. FAU - Li, Xiuqin AU - Li X AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. FAU - Yin, Xiong AU - Yin X AD - College of Chemistry, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. LA - eng PT - Journal Article DEP - 20260623 PL - Netherlands TA - Food Chem X JT - Food chemistry: X JID - 101751436 PMC - PMC13316758 OTO - NOTNLM OT - Certified reference material OT - Commercial samples OT - Infant formula OT - QuEChERS-UPLC-DAD OT - Vitamers COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/01 06:34 MHDA- 2026/07/01 06:35 PMCR- 2026/06/23 CRDT- 2026/07/01 05:17 PHST- 2026/03/22 00:00 [received] PHST- 2026/06/17 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/01 06:35 [medline] PHST- 2026/07/01 06:34 [pubmed] PHST- 2026/07/01 05:17 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - S2590-1575(26)00652-8 [pii] AID - 104131 [pii] AID - 10.1016/j.fochx.2026.104131 [doi] PST - epublish SO - Food Chem X. 2026 Jun 23;37:104131. doi: 10.1016/j.fochx.2026.104131. eCollection 2026 Jul. PMID- 42382175 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 17 DP - 2026 TI - Pharmacogenomic impact and genetic architecture of toxicity in pediatric acute lymphoblastic leukemia induction therapy: an exploratory modeling approach. PG - 1830183 LID - 10.3389/fphar.2026.1830183 [doi] LID - 1830183 AB - Induction chemotherapy for pediatric Acute Lymphoblastic Leukemia (ALL) is highly curative but accompanied by a severe toxicity profile. Evaluating the genetic susceptibility to these adverse events could inform hypothesis-generating risk stratification. In this exploratory retrospective cohort study (N = 178), we investigated the influence of 14 candidate pharmacogenetic variants on the development of prevalent Adverse Drug Reactions (ADRs, >/= 10 events). Multiple logistic regression, adjusted for basic demographic and anthropometric covariates (age and body surface area), was utilized across comprehensive inheritance architectures (additive, dominant, recessive, and co-dominant). For clinical translation hypothesis generation, we applied LASSO-penalized logistic regression (alpha = 1), 10-fold cross-validation to derive parsimonious Pharmacogenetic Risk Scores (PGRS). Model performance was evaluated using the optimism-corrected Area Under the Receiver Operating Characteristic Curve (AUC) via 1000-iteration bootstrap resampling, and calibration was assessed via the Brier score. We observed several complex interactions, notably suggesting an increased risk of severe neutropenia in patients carrying a homozygous variant CYP3A5 rs776746 genotype (nominally significant OR 5.58, p = 0.006) and a potential pleiotropic protective effect from NFATC2 rs6021191 (OR 0.09, p = 0.001). Penalized selection allowed the construction of compact, multi-locus mathematical risk scores that demonstrated promising diagnostic discrimination for Neutropenia (optimism-corrected AUC 0.793, 95% CI 0.72-0.85; Brier score 0.12), while displaying limited to moderate performance for other clinically discriminating toxicities like Infection (AUC 0.650) and Gastrointestinal complications (AUC 0.607). The primary contribution of this study is the prioritization of pharmacogenomic candidate signals rather than the proposal of models ready for clinical intervention. The integration of alternative genotype parameterizations and regularized machine learning highlights pathways for future predictive research. However, given the retrospective nature of the study and inherent risks of internal optimism, these scores serve as biologically informed proof-of-concept models that strictly require robust prospective external validation. CI - Copyright (c) 2026 Gutierrez-Caceres, Alarcon-Concha, Aracena-Farias, Torres, Acuna, Sandoval, Silva, Ormeno, Oyarce, Cerpa and Martinez. FAU - Gutierrez-Caceres, Carolina AU - Gutierrez-Caceres C AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Faculty of Pharmacy, University of Concepcion, Concepcion, Chile. FAU - Alarcon-Concha, Claudio AU - Alarcon-Concha C AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Laboratory of Chemical Carcinogenesis and Pharmacogenetics (CQF), Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago, Chile. FAU - Aracena-Farias, Javiera AU - Aracena-Farias J AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. FAU - Torres, Esperanza AU - Torres E AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. FAU - Acuna, Ivan AU - Acuna I AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. FAU - Sandoval, Tamara AU - Sandoval T AD - Faculty of Pharmacy, University of Concepcion, Concepcion, Chile. FAU - Silva, Pamela AU - Silva P AD - Hospital de Ninos Roberto del Rio, Santiago, Chile. FAU - Ormeno, Maricruz AU - Ormeno M AD - Hospital Luis Calvo Mackenna, Santiago, Chile. FAU - Oyarce, Veronica AU - Oyarce V AD - Hospital Exequiel Gonzalez Cortes, Santiago, Chile. AD - Centro de Investigacion Clinica Avanzada (CICA) Hospital Exequiel Gonzalez Cortes - Facultad de Medicina Universidad de Chile, Santiago, Chile. FAU - Cerpa, Leslie C AU - Cerpa LC AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Laboratory of Chemical Carcinogenesis and Pharmacogenetics (CQF), Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago, Chile. AD - Center for Cancer Prevention and Control (CECAN), Santiago, Chile. AD - Latin American Network for Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Santiago, Chile. FAU - Martinez, Matias F AU - Martinez MF AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Centro de Investigacion Clinica Avanzada (CICA) Hospital Exequiel Gonzalez Cortes - Facultad de Medicina Universidad de Chile, Santiago, Chile. AD - Latin American Network for Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Santiago, Chile. LA - eng PT - Journal Article DEP - 20260616 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC13314868 OTO - NOTNLM OT - acute lymphoblastic leukemia OT - adverse drug reaction OT - pediatric oncohematology OT - pharmacogenomics OT - polygenic risk score (PGRS) OT - precision medicine COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/06/16 CRDT- 2026/07/01 05:09 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 05:09 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 1830183 [pii] AID - 10.3389/fphar.2026.1830183 [doi] PST - epublish SO - Front Pharmacol. 2026 Jun 16;17:1830183. doi: 10.3389/fphar.2026.1830183. eCollection 2026. PMID- 42382157 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2215-0161 (Print) IS - 2215-0161 (Electronic) IS - 2215-0161 (Linking) VI - 17 DP - 2026 Dec TI - Effectiveness of a posture education program in high school students: A randomized controlled trial protocol. PG - 104006 LID - 10.1016/j.mex.2026.104006 [doi] LID - 104006 AB - Adolescents are increasingly exposed to sedentary behaviours and poor ergonomic environments that may adversely affect posture, aerobic capacity, and psychological well-being. This article describes a standardized protocol for implementing and evaluating an 8-week Posture Education Program (PEP) among high school students aged 14-17 years using a randomized controlled trial design. The intervention includes postural awareness, core strengthening, ergonomic correction, guided movement, and reflective behavioural activities delivered during physical education sessions. The control group will continue standard physical education without posture-specific training. The program was developed using the ADDIE instructional framework, while the International Classification of Functioning, Disability and Health framework guided outcome selection. Primary outcomes include postural alignment, aerobic capacity, and lung function. Secondary outcomes include physical activity, psychological well-being, and ergonomic knowledge and behaviour. This protocol provides a reproducible framework for school-based posture education interventions and integrates multidimensional assessment of postural, cardiorespiratory, behavioural, and psychological outcomes within a school-based adolescent population. Structured 8-week school-based posture education intervention integrated into physical education sessions. Multidimensional assessment of posture, aerobic capacity, lung function, and psychological well-being. Reproducible randomized controlled trial protocol guided by ADDIE and ICF frameworks. CI - (c) 2026 The Author(s). FAU - Valaitham, Jeyanthi AU - Valaitham J AD - Physiotherapy Programme, Centre for Rehabilitation and Special Needs Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. FAU - Zanudin, Asfarina AU - Zanudin A AD - Physiotherapy Programme, Centre for Rehabilitation and Special Needs Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. FAU - Mohamad Nasri, Nurfaradilla AU - Mohamad Nasri N AD - Centre of Educational Leadership and Policy, Faculty of Education, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. FAU - Ramli, Ayiesah AU - Ramli A AD - Physiotherapy Programme, Centre for Rehabilitation and Special Needs Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. LA - eng PT - Journal Article DEP - 20260613 PL - Netherlands TA - MethodsX JT - MethodsX JID - 101639829 PMC - PMC13314789 OTO - NOTNLM OT - Adolescents OT - Cardiorespiratory fitness OT - Ergonomics OT - Postural alignment OT - Posture education OT - Randomized controlled trial OT - School-based intervention COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/01 06:34 MHDA- 2026/07/01 06:35 PMCR- 2026/06/13 CRDT- 2026/07/01 05:09 PHST- 2026/04/17 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/07/01 06:35 [medline] PHST- 2026/07/01 06:34 [pubmed] PHST- 2026/07/01 05:09 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - S2215-0161(26)00224-4 [pii] AID - 104006 [pii] AID - 10.1016/j.mex.2026.104006 [doi] PST - epublish SO - MethodsX. 2026 Jun 13;17:104006. doi: 10.1016/j.mex.2026.104006. eCollection 2026 Dec. PMID- 42382020 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 0915-5287 (Print) IS - 2187-5626 (Electronic) IS - 0915-5287 (Linking) VI - 38 IP - 7 DP - 2026 Jul TI - Design and development of a universal OMNI exertion faces scale. PG - 324-329 LID - 10.1589/jpts.38.324 [doi] AB - [Purpose] To design and develop a new OMNI Exertion Faces Scale (OMNI Faces) that uses universal design criteria to improve acceptability for measuring perceived exertion across age groups, physical activities, and clinical populations. [Methods] The OMNI Faces Scale was developed in collaboration with the original OMNI creator and refined through consultations with educators, speech-language pathologists, clinicians, and feedback from children and adults. Design considerations included universal accessibility, simplified instructions, and alignment with the Heart Rate Reserve method. [Design Features] The OMNI Faces Scale includes five verbal descriptors and five pictorial images to reduce inconsistencies with language, activity-specific visuals, and anchoring among prior versions. The OMNI Faces Scale is non-gendered, non-activity-specific, and has accessible fonts. Instructions were simplified to 71 words relevant for assessing perceived exertion during both aerobic and resistance activities. [Conclusions] The OMNI Faces Scale was designed to provide a versatile and inclusive tool for monitoring exertion in children and adults across a broad range of physical activity applications. Future research will validate its psychometric properties across populations and activity types and explore multilingual adaptations. CI - 2026(c)by the Society of Physical Therapy Science. Published by IPEC Inc. FAU - Schlessman, Amy AU - Schlessman A AD - Department of Rehabilitation Sciences, School of Medicine, Tufts University: 145 Harrison Avenue Boston, MA, USA. FAU - Wickstrom, Rick AU - Wickstrom R AD - Workability Systems, Inc., USA. FAU - Petrosino, Chris AU - Petrosino C AD - Sacred Heart University, USA. FAU - Robertson, Robert AU - Robertson R AD - University of Pittsburgh, USA. LA - eng PT - Journal Article DEP - 20260701 PL - Japan TA - J Phys Ther Sci JT - Journal of physical therapy science JID - 9105359 PMC - PMC13318445 OTO - NOTNLM OT - OMNI Faces Scale OT - Perceived exertion OT - Physical activity COIS- Authors Rick Wickstrom (second author), Amy Schlessman (first author), and Robert Robertson (fourth author) developed the OMNI Exertion Faces Scale. Christopher Petrosino (third author) declares no conflict of interest. This universal design project to develop the OMNI Faces Exertion Scale was Dr. Robertson's last research contribution as a Professor Emeritus at the University of Pittsburgh before he passed away peacefully on November 14, 2025, at age 82. His patience, clarity, and encouragement shaped countless careers of students and colleagues and reflected his lifelong passion for exercise science across the lifespan. EDAT- 2026/07/01 06:34 MHDA- 2026/07/01 06:35 PMCR- 2026/07/01 CRDT- 2026/07/01 05:07 PHST- 2026/01/08 00:00 [received] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/07/01 06:35 [medline] PHST- 2026/07/01 06:34 [pubmed] PHST- 2026/07/01 05:07 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 2025-152 [pii] AID - 10.1589/jpts.38.324 [doi] PST - ppublish SO - J Phys Ther Sci. 2026 Jul;38(7):324-329. doi: 10.1589/jpts.38.324. Epub 2026 Jul 1. PMID- 42381602 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - The Expanded Biopsychosocial Model Elucidates the Association Between Pre-Pregnancy Overweight/Obesity and Delayed Lactogenesis II: A Prospective Cohort Study. PG - e70225 LID - 10.1111/mcn.70225 [doi] LID - e70225 AB - Pre-pregnancy overweight or obesity delays the onset of lactogenesis II, posing an early barrier to achieving optimal infant nutrition and long-term health. However, the underlying pathophysiological mechanisms remain incompletely elucidated. This prospective cohort study conducted in China aimed to delineate the distinct pathways through which pre-pregnancy overweight/obesity, compared to normal body mass index (BMI), leads to delayed lactogenesis II. Guided by an expanded biopsychosocial framework, we enrolled and stratified 296 primiparous women into pre-pregnancy overweight/obese (n = 146) and normal BMI (n = 150) groups. Data on biological, psychological, social, and infant-related factors were collected prospectively at prenatal, delivery, and one-week postpartum stages. Structural equation modeling was used to identify and compare the mediating pathways between the two groups. Results demonstrated that the association between pre-pregnancy overweight/obesity and delayed lactogenesis II was primarily mediated through four distinct pathways: biological (e.g., breastfeeding difficulties: beta = 0.203, 95% CI: 0.144-0.265, p < 0.001), psychological (e.g., internalized weight stigma: beta = 0.095, 95% CI: 0.016-0.181, p = 0.026), social (e.g., reduced pro-breastfeeding practices: beta = 0.076, 95% CI: 0.017-0.144, p = 0.019), and infant-related (e.g., higher formula intake: beta = 0.114, 95% CI: 0.047-0.195, p = 0.003). This study validates the expanded biopsychosocial model by elucidating the distinct pathways through which pre-pregnancy overweight/obesity contributes to delayed lactogenesis II. These findings underscore the necessity for clinical practice to move beyond a purely biological focus and advocate for a paradigm shift in clinical support towards integrated, multi-faceted interventions tailored to this vulnerable population. TRIAL REGISTRATION: This study was registered at the Chinese Clinical Trial Registry (registry number: ChiCTR2200057038). The trial was registered on February 26, 2022. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Ren, Ziqi AU - Ren Z AUID- ORCID: 0000-0002-5285-5794 AD - School of Nursing, Nanjing Medical University, Nanjing, Jiangning District, China. FAU - Zhang, Aixia AU - Zhang A AUID- ORCID: 0000-0002-1266-0925 AD - Department of Nursing, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Qinhuai District, China. FAU - Zhang, Jingjing AU - Zhang J AD - Department of Nursing, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Qinhuai District, China. FAU - Fan, Xuemei AU - Fan X AD - Department of Nursing, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Qinhuai District, China. FAU - Tang, Huiting AU - Tang H AD - School of Nursing, Nanjing Medical University, Nanjing, Jiangning District, China. LA - eng GR - 72204123/National Natural Science Foundation of China Youth Program/ GR - FNF202102/Nursing Scientific Research at Fudan University/ GR - Jiangsu Education Departmentleft broken bracket2023right broken bracketNo.11/Project of "Nursing Science" Funded by the 4th Priority Discipline Development Program of Jiangsu Higher Education Institutions/ PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - Prospective Studies MH - Pregnancy MH - Adult MH - *Overweight/physiopathology MH - *Lactation/physiology/psychology MH - Breast Feeding/psychology/statistics & numerical data MH - *Obesity/physiopathology MH - China/epidemiology MH - Body Mass Index MH - *Pregnancy Complications MH - Infant, Newborn PMC - PMC13320373 OTO - NOTNLM OT - biopsychosocial model OT - breastfeeding OT - lactogenesis II OT - maternity care OT - mechanisms OT - mediating pathways OT - pre-pregnancy obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/01 06:33 MHDA- 2026/07/01 16:11 PMCR- 2026/07/01 CRDT- 2026/07/01 04:53 PHST- 2026/04/07 00:00 [revised] PHST- 2025/12/11 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/01 16:11 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 04:53 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - MCN70225 [pii] AID - 10.1111/mcn.70225 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70225. doi: 10.1111/mcn.70225. PMID- 42381598 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Potential Donors' Awareness and Perceived Feasibility of Donating Human Milk in Australia. PG - e70224 LID - 10.1111/mcn.70224 [doi] LID - e70224 AB - Human milk banks rely on voluntary donations from lactating individuals producing more milk than their baby needs, to make pasteurised donor human milk (PDHM) for preterm babies. Demand for PDHM is increasing, as is the need for donors. Few Australian studies have explored potential donors' awareness and perceived feasibility of donating to a milk bank. We aimed to survey women breastfeeding their own child (< 24 months) or pregnant (and intending to breastfeed), and residing in major metropolitan areas of Australia, to determine their awareness of milk banks, and interest in and perceived feasibility (ease, eligibility) of donating to a milk bank. 1221 participants completed the survey (112 pregnant women, 1109 breastfeeding women). Most (78%) had heard of milk banks, and 81.7% lived in an area eligible to donate to a milk bank, yet only 11% were aware of a milk bank in their area. Most (60%) pregnant women would prefer to use online sources or health professionals to find information about donation. Most breastfeeding women (77%) were interested in donating milk, however only 26% thought it would be easy to meet milk bank requirements, and that they would be eligible to donate. Barriers to donating for breastfeeding women involved having no excess milk to donate, lack of time to express/donate, and lack of space to store milk. Awareness raising of local milk banks, promotion of donation information amongst healthcare professionals, and modifications to improve feasibility of donation will likely engage new potential donors and ensure sustainability of milk banks. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Hyde, Melissa K AU - Hyde MK AUID- ORCID: 0000-0001-9616-2028 AD - School of Psychology, The University of Queensland, Brisbane, Queensland, Australia. AD - Strategic Transformation & Readiness, Australian Red Cross Lifeblood, Melbourne, Victoria, Australia. FAU - Newman, Claire AU - Newman C AUID- ORCID: 0000-0001-7614-931X AD - Strategy and Growth, Australian Red Cross Lifeblood, Alexandria, New South Wales, Australia. FAU - Edwards, Abigail R-A AU - Edwards AR AUID- ORCID: 0000-0002-1169-1738 AD - School of Psychology, The University of Queensland, Brisbane, Queensland, Australia. AD - Strategic Transformation & Readiness, Australian Red Cross Lifeblood, Melbourne, Victoria, Australia. FAU - Clifford, Vanessa AU - Clifford V AUID- ORCID: 0000-0001-9758-867X AD - Strategy and Growth, Australian Red Cross Lifeblood, Alexandria, New South Wales, Australia. AD - Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia. FAU - Masser, Barbara M AU - Masser BM AUID- ORCID: 0000-0001-9385-6497 AD - School of Psychology, The University of Queensland, Brisbane, Queensland, Australia. AD - Strategic Transformation & Readiness, Australian Red Cross Lifeblood, Melbourne, Victoria, Australia. AD - Department of Public Health and Primary Care, National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, England, UK. FAU - Klein, Laura D AU - Klein LD AUID- ORCID: 0000-0002-7287-8029 AD - Strategy and Growth, Australian Red Cross Lifeblood, Alexandria, New South Wales, Australia. LA - eng GR - #2024589/National Health and Medical Research Council/ GR - GO6587/Australian Government Department of Health, Disability and Ageing/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - *Milk Banks/statistics & numerical data MH - Australia MH - *Milk, Human MH - Adult MH - *Tissue Donors/psychology MH - Breast Feeding MH - *Health Knowledge, Attitudes, Practice MH - Pregnancy MH - Surveys and Questionnaires MH - Infant, Newborn MH - Young Adult MH - Feasibility Studies MH - Awareness MH - Infant PMC - PMC13320368 OTO - NOTNLM OT - attitudes OT - awareness OT - breastfeeding OT - human milk OT - milk banks OT - potential donors COIS- MKH, CN, AE, VC, BMM, and LDK are current or former employees or affiliates of Australian Red Cross Lifeblood, which provides pasteurised donor human milk to hospitals in Australia. The authors do not have any other conflicts of interest to declare. EDAT- 2026/07/01 06:33 MHDA- 2026/07/01 18:33 PMCR- 2026/07/01 CRDT- 2026/07/01 04:53 PHST- 2026/05/10 00:00 [revised] PHST- 2025/07/30 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/01 18:33 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 04:53 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - MCN70224 [pii] AID - 10.1111/mcn.70224 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70224. doi: 10.1111/mcn.70224. PMID- 42381294 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 1308-8734 (Print) IS - 1308-8742 (Electronic) IS - 1308-8734 (Linking) VI - 58 IP - 4 DP - 2026 Jun 15 TI - Peripheral Nitrosative Stress in Pediatric Anxiety Disorders: Elevated Serum Nitric Oxide Levels. PG - 1-6 LID - 10.5152/eurasianjmed.2026.251235 [doi] LID - e251235 AB - BACKGROUND: The developing pediatric brain is vulnerable to nitrosative stress. This study investigated serum nitric oxide (NO), inducible nitric oxide synthase (iNOS), and S-nitrosothiols (SNOs) as peripheral biomarkers in children with anxiety disorders (ADs) and their associations with symptom severity. METHODS: Eighty-one participants aged 7-17 years were enrolled, including 40 drug-naive participants with ADs and 41 age- and sex-matched healthy controls (HCs). Diagnoses were established using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version, DSM-5- Turkish version (K-SADS-PL-DSM-5-T). Symptom severity was assessed using the Screen for Child Anxiety Related Emotional Disorders (SCARED) and the Clinical Global Impression-Severity (CGI-S) Scale. Data were analyzed using between-group comparisons, correlation analyses, covariance analyses (MANCOVA/ ANCOVA), controlling for age, sex, and body mass index (BMI), and receiver operating characteristic (ROC) analysis. RESULTS: Serum NO levels were significantly higher in the AD group compared with HCs (P = .028), whereas iNOS and SNO levels did not differ (P > .05). In adjusted analyses controlling for age, sex, and BMI, NO remained significantly higher, and iNOS and SNO levels were also significantly higher in the AD group. No marker (NO, iNOS, SNOs) correlated significantly with anxiety severity (all P > .05). Receiver operating characteristic analysis indicated modest diagnostic accuracy for NO (area under the curve (AUC) = 0.629, 95% CI: 0.506-0.752, P = .046), while iNOS and SNOs were not significant. CONCLUSION: Elevated NO, alongside adjusted increases in iNOS and SNO, supports altered peripheral nitrosative signaling in pediatric ADs. Nitric oxide showed modest discriminative value. Cite this article as: Okuyucu M, Ceylan MF, Hesapcioglu ST, Kafali S, Neselioglu S, Erel O. Peripheral nitrosative stress in pediatric anxiety disorders: elevated serum nitric oxide levels. Eurasian J Med. 2026, 58(4), 1235, doi:10.5152/eurasianjmed.2026.251235. FAU - Okuyucu, Merve AU - Okuyucu M AD - Department of Child and Adolescent Psychiatry, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkiye. FAU - Ceylan, Mehmet Fatih AU - Ceylan MF AD - Department of Child and Adolescent Psychiatry, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. FAU - Hesapcioglu, Selma Tural AU - Hesapcioglu ST AD - Department of Child and Adolescent Psychiatry, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. FAU - Kafali, Seda AU - Kafali S AD - Department of Child and Adolescent Psychiatry, Kirikkale Yuksek Ihtisas Hospital, Kirikkale, Turkiye. FAU - Neselioglu, Salim AU - Neselioglu S AD - Department of Biochemistry, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. FAU - Erel, Ozcan AU - Erel O AD - Department of Biochemistry, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260615 PL - Turkey TA - Eurasian J Med JT - The Eurasian journal of medicine JID - 101557701 PMC - PMC13324883 COIS- Declaration of Interests: The authors have no conflicts of interest to declare. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/06/15 CRDT- 2026/07/01 01:42 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 01:42 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - eajm-58-4-251235 [pii] AID - 10.5152/eurasianjmed.2026.251235 [doi] PST - epublish SO - Eurasian J Med. 2026 Jun 15;58(4):1-6. doi: 10.5152/eurasianjmed.2026.251235. PMID- 42380924 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260925 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 30 TI - Low serum vitamin D levels are associated with neonatal indirect hyperbilirubinemia and prolonged phototherapy duration: a retrospective case-control study. LID - 10.1186/s12887-026-07234-2 [doi] LID - 896 AB - OBJECTIVE: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels, indirect hyperbilirubinemia severity, and phototherapy duration in term neonates. METHODS: This retrospective case-control study included 79 term neonates admitted to a tertiary neonatal intensive care unit between March 2023 and March 2024. Thirty-nine neonates requiring phototherapy for indirect hyperbilirubinemia (case group) were compared with 40 healthy term neonates (control group). Clinical and biochemical parameters, including bilirubin, 25(OH)D, calcium, phosphorus, magnesium, and alkaline phosphatase levels, were evaluated. Correlation, receiver operating characteristic [ROC], and multivariable regression analyses were performed to assess the association between vitamin D status and phototherapy duration in indirect hyperbilirubinemia. RESULTS: Serum 25(OH)D levels were significantly lower in neonates requiring phototherapy, with 75% demonstrating vitamin D deficiency (< 20 ng/mL). Lower vitamin D levels were associated with prolonged phototherapy duration (r = - 0.337, p = 0.036). Although no significant linear correlation was observed between serum 25(OH)D concentration and baseline bilirubin levels, neonates with vitamin D concentrations < 20 ng/mL exhibited significantly higher bilirubin levels than those with concentrations >/= 20 ng/mL. ROC analysis demonstrated moderate predictive performance for prolonged phototherapy duration (AUC = 0.78, 95% CI: 0.67-0.88). The optimal cutoff value was 17.2 ng/mL, yielding a sensitivity of 84% and specificity of 69%. Multivariable regression analysis identified serum vitamin D level and baseline bilirubin concentration as significant predictors of phototherapy duration. CONCLUSION: Lower serum 25(OH)D concentrations were associated with indirect hyperbilirubinemia and prolonged phototherapy duration in term neonates. Larger prospective studies are needed to confirm these findings and clarify their clinical significance. CI - (c) 2026. The Author(s). FAU - Demir, Batuhan Berk AU - Demir BB AUID- ORCID: 0000-0002-0349-5112 AD - Department of Pediatrics, Kutahya City Hospital/Kutahya Health Sciences University, Kutahya, Turkiye. mdbatuhanberkdemir@gmail.com. FAU - Hazer, Ilhan AU - Hazer I AD - Department of Pediatric Endocrinology, Kutahya City Hospital/Kutahya Health Sciences University, Kutahya, Turkiye. FAU - Turkeli, Ahmet AU - Turkeli A AD - Department of Pediatric Allergy and Immunology, Kutahya City Hospital/Kutahya Health Sciences University, Kutahya, Turkiye. LA - eng PT - Journal Article DEP - 20260630 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) RN - RFM9X3LJ49 (Bilirubin) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Retrospective Studies MH - *Phototherapy MH - Case-Control Studies MH - *Vitamin D/blood/analogs & derivatives MH - Infant, Newborn MH - Male MH - *Hyperbilirubinemia, Neonatal/therapy/blood/complications MH - Female MH - *Vitamin D Deficiency/complications/blood MH - ROC Curve MH - Bilirubin/blood MH - Biomarkers/blood PMC - PMC13599256 COIS- Declarations. Ethics approval and consent to participate: This retrospective case-control study was approved by the Kutahya Health Sciences University Non-Interventional Clinical Research Ethics Committee (Decision No: 2024/11-35; Date: 30 September 2024). The study was conducted in accordance with the ethical principles of the Declaration of Helsinki. As the study was retrospective and based on archived hospital records, informed consent was waived by the ethics committee. Competing interests: The authors declare no competing interests. EDAT- 2026/07/01 06:35 MHDA- 2026/09/23 05:35 PMCR- 2026/06/30 CRDT- 2026/07/01 00:41 PHST- 2026/05/01 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/23 05:35 [medline] PHST- 2026/07/01 06:35 [pubmed] PHST- 2026/07/01 00:41 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.1186/s12887-026-07234-2 [pii] AID - 7234 [pii] AID - 10.1186/s12887-026-07234-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 30;26(1):896. doi: 10.1186/s12887-026-07234-2. PMID- 42380910 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260920 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 30 TI - Predicting abnormal birth weight and identifying associated factors using machine learning in the Hararghe Health and Demographic Surveillance System, Ethiopia. LID - 10.1186/s12889-026-28135-0 [doi] LID - 2622 AB - BACKGROUND: Birth weight is a reliable indicator of intrauterine growth and an important predictor of neonatal survival, growth, and long-term development. Globally, approximately 15.5% of live births are low birth weight, and nearly 10% are macrosomic (high birth weight), with a substantial proportion of these cases occurring in sub-Saharan Africa. Birth weights outside the normal range of 2,500-4,000 g are considered abnormal and are associated with increased risks of neonatal and maternal complications. Ethiopia is similarly affected by the growing burden of abnormal birth weight. METHODS: A retrospective cross-sectional study design using secondary HDSS data collected from 2015 to 2022 was employed. This design was considered appropriate because the study aimed to develop machine learning models using routinely collected surveillance data to predict abnormal birth weight and identify associated factors, rather than to establish causal relationships. All singleton births were included, and those with missing birth weight data were excluded. Six machine learning algorithms identified from the literature were built and compared to identify the best-performing model for predicting abnormal birth weight. Prior observational studies and expert opinion were used to select the candidate features for all models. The synthetic minority oversampling technique (SMOTE) was used to manage the imbalance in the dataset. The dataset was split into training (80%, n = 9,242) and testing (20%, n = 2,311) subsets for model development and evaluation. Hyper-parametric tuning was performed using grid search combined with 10-fold cross-validation to optimize model performance and reduce over-fitting. Model performance was evaluated using the area under the receiver operating characteristic curve (AUROC), accuracy, precision, F1-score, and Kappa. Feature importance analysis was done using Shapley Additive explanation (SHAP) values. RESULTS: The Descriptive analysis of 11,553 singleton births showed that 10.78% of the newborns had high birth weight (HBW) and 9.28% had low birth weight (LBW). The eXtreme Gradient Boosting (XGBoost) model performed best by achieving an AUC of 0.835, an accuracy of 0.72, a precision of 0.67, an F1-score of 0.63, a recall of 0.54, and a kappa of 0.52 for abnormal birth weight prediction. The feature importance analysis showed that the top predictors for the low birth weight (LBW) include maternal educational status, age at first delivery, and antenatal care (ANC) visit, while high birth weight (HBW) was strongly predicted by antenatal care (ANC) visit, maternal literacy status, age at first delivery, and maternal education. CONCLUSION: Machine learning models showed moderate performance in predicting abnormal birth weight using HDSS surveillance data. Maternal educational characteristics, age at first delivery, and ANC utilization were identified as important predictive features. However, the findings should be interpreted cautiously because the model identified predictive associations rather than causal relationships. Further studies incorporating additional maternal clinical and nutritional variables, as well as external validation datasets, are recommended to improve predictive performance and generalizability. CI - (c) 2026. The Author(s). FAU - Abdeta, Sington AU - Abdeta S AD - College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. singtonabdeta128@gmail.com. FAU - Diop, Ousmane AU - Diop O AD - The Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal. FAU - Cygu, Steve AU - Cygu S AD - African Population and Health Research Center (APHRC), Nairobi, Kenya. FAU - Drame, Aboubacry AU - Drame A AD - Ministry of Health, Dakar, Senegal. FAU - Momanyi, Reinpeter AU - Momanyi R AD - African Population and Health Research Center (APHRC), Nairobi, Kenya. FAU - Endalamaw Dejene, Belayneh AU - Endalamaw Dejene B AD - University of Gondar, Gondar, Ethiopia. AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Tadele, Mulugeta AU - Tadele M AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Sintayehu, Yordanos AU - Sintayehu Y AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Barasa, Miranda AU - Barasa M AD - African Population and Health Research Center (APHRC), Nairobi, Kenya. FAU - Woldie, Mirkuzie AU - Woldie M AD - Fenot Associates, Addis Ababa, Ethiopia. FAU - Girma, Tsinuel AU - Girma T AD - Fenot Associates, Addis Ababa, Ethiopia. FAU - Tsegaye, Rosa AU - Tsegaye R AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Kiragga, Agnes AU - Kiragga A AD - African Population and Health Research Center (APHRC), Nairobi, Kenya. FAU - Adnew, Bethlehem AU - Adnew B AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Howe, Rawleigh AU - Howe R AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Dheresa, Merga AU - Dheresa M AD - College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. FAU - Abdisa, Alemseged AU - Abdisa A AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20260630 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Female MH - Retrospective Studies MH - Cross-Sectional Studies MH - Predictive Learning Models MH - *Machine Learning MH - *Birth Weight MH - Infant, Newborn MH - Prediction Algorithms MH - Adult MH - Risk Factors MH - Male MH - Classification Algorithms MH - *Population Surveillance MH - Pregnancy PMC - PMC13587436 OTO - NOTNLM OT - Abnormal birth weight OT - Associated factors OT - Ethiopia OT - Hararghe HDSS OT - Machine learning OT - Prediction COIS- Declarations. Ethics approval and consent to participate: The Hararghe Health and Demographic Surveillance System (HDSS) received ethical approval from the Institutional Review Board (IRB) of Haramaya University. During the original data collection, written informed consent was obtained from all participants aged 18 years and above, as well as from the legal guardians of participants under 18 years. Verbal assent was additionally obtained from children under 18 years. All procedures were conducted in accordance with the Declaration of Helsinki and other relevant guidelines. The Hararghe HDSS coordinator granted permission to access and use the HDSS data for research purposes. To maintain confidentiality, all data were de-identified before analysis, with personal identifiers such as names and child ID removed. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/01 06:33 MHDA- 2026/09/18 05:36 PMCR- 2026/06/30 CRDT- 2026/07/01 00:40 PHST- 2026/03/25 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/09/18 05:36 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 00:40 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.1186/s12889-026-28135-0 [pii] AID - 28135 [pii] AID - 10.1186/s12889-026-28135-0 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 30;26(1):2622. doi: 10.1186/s12889-026-28135-0. PMID- 42380694 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260831 IS - 1463-1326 (Electronic) IS - 1462-8902 (Print) IS - 1462-8902 (Linking) VI - 28 IP - 9 DP - 2026 Sep TI - Pubertal Stage-Based One-hour Postload Glucose Thresholds Improve Identification of Prediabetes and Type 2 Diabetes in Children With Overweight or Obesity. PG - 8469-8481 LID - 10.1111/dom.70969 [doi] AB - AIMS: One-hour postload plasma glucose (1h-PG) is an early marker of dysglycemia in adults, but its utility in children and adolescents is uncertain because insulin sensitivity changes during growth and puberty. We aimed to establish age- and pubertal stage-specific 1h-PG thresholds for identifying prediabetes and Type 2 diabetes (T2D) in children with overweight or obesity. MATERIALS AND METHODS: In this cross-sectional study, 4344 children and adolescents with overweight or obesity underwent an oral glucose tolerance test. Participants were classified into four groups: normal glucose tolerance (NGT) with normal 1 h-PG, NGT with elevated 1 h-PG, prediabetes and T2D. Insulin resistance and beta-cell function indices were assessed. Participants were stratified by chronological age and pubertal stage. The optimal 1h-PG cut-offs were obtained via receiver operating characteristic (ROC) and age- and pubertal stage-based thresholds were compared for diagnostic performance. These thresholds were then validated in two independent cohorts. RESULTS: Among individuals with NGT, those with elevated 1h-PG exhibited greater insulin resistance, impaired beta-cell function and a higher insulin area under the curve (29 916 vs. 23 524, p < 0.001). 1 h-PG levels increased with pubertal progression. Pubertal stage-specific thresholds showed superior discrimination compared with age-based stratification and adult cut-offs. Compared with adult thresholds (8.6 mmol/L for prediabetes and 11.6 mmol/L for T2D), a prepubertal cut-off of 7.78 mmol/L improved sensitivity for prediabetes (75.40% vs. 56.68%) and a pubertal cut-off of 10.48 mmol/L improved sensitivity for T2D (89.47% vs. 73.68%). CONCLUSIONS: Elevated 1h-PG proved to be a practical marker for identifying early metabolic dysfunction in children and adolescents with euglycemia. Given that widely used adult-derived cut-offs (8.6 and 11.6 mmol/L) are suboptimal for pediatric populations, we established pubertal stage-specific thresholds that outperformed both age-specific and adult-derived cut-offs. These stage-specific thresholds may serve as an effective screening tool for diabetes risk in children and adolescents with overweight or obesity. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Wu, Zhaoyuan AU - Wu Z AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Li, Yangxi AU - Li Y AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Qin, Zhewen AU - Qin Z AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Liu, Yaru AU - Liu Y AUID- ORCID: 0000-0002-9758-5951 AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Le, Kaixing AU - Le K AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Zhou, Xuelian AU - Zhou X AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Sun, Yan AU - Sun Y AD - Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. FAU - Huang, Ke AU - Huang K AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Wu, Wei AU - Wu W AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Dong, Guanping AU - Dong G AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Fu, Junfen AU - Fu J AUID- ORCID: 0000-0001-6405-1251 AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. LA - eng GR - 2023ZD0508200/Noncommunicable Chronic Diseases-National Science and Technology Major Project/ GR - 2023ZD0508204/Noncommunicable Chronic Diseases-National Science and Technology Major Project/ GR - Zhejiang Province Multidisciplinary Innovative Team for the Diagnosis and Treatment of Diabetes with Traditional Chinese Medicine/ GR - YXH2024YS028/2024 Shandong Medical Association Scientific Research Project/ PT - Journal Article DEP - 20260630 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/diagnosis/blood/complications MH - *Prediabetic State/diagnosis/blood/complications MH - Male MH - Child MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Glucose Tolerance Test MH - *Puberty/blood MH - *Blood Glucose/metabolism/analysis MH - Insulin Resistance MH - *Pediatric Obesity/complications/blood MH - *Overweight/complications/blood MH - Biomarkers/blood MH - Insulin-Secreting Cells PMC - PMC13448984 OTO - NOTNLM OT - 1-h postprandial plasma glucose OT - Type 2 diabetes OT - children OT - insulin resistance OT - beta cell function COIS- The authors declare no conflicts of interest. EDAT- 2026/07/01 10:11 MHDA- 2026/08/07 12:39 PMCR- 2026/08/07 CRDT- 2026/07/01 00:27 PHST- 2026/05/25 00:00 [revised] PHST- 2026/03/05 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/07 12:39 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 00:27 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - DOM70969 [pii] AID - 10.1111/dom.70969 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Sep;28(9):8469-8481. doi: 10.1111/dom.70969. Epub 2026 Jun 30. PMID- 42380517 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261008 IS - 1434-4726 (Electronic) IS - 0937-4477 (Linking) VI - 283 IP - 9 DP - 2026 Sep TI - Adenoid-Nasopharyngeal Ratio and craniofacial growth in Children: A two-center longitudinal study with threshold and causal analyses. PG - 5791-5802 LID - 10.1007/s00405-026-10387-6 [doi] AB - PURPOSE: Adenoid hypertrophy is a common cause of pediatric upper-airway obstruction and is suspected to contribute to "adenoid facies", but longitudinal thresholds and causal dose-response relations between the adenoid-nasopharyngeal (A/N) ratio and craniofacial growth indices remain unclear. METHODS: We performed a two-center longitudinal cohort study of children aged 3-10 years who underwent clinically indicated lateral nasopharyngeal or cephalometric radiography between July 2021 and July 2024 at tertiary pediatric hospitals in Shanghai and Chongqing, China. Children with at least two eligible radiographic visits were included. The exposure was the distance-based A/N ratio at the earlier visit. Outcomes were annualized changes in standard cephalometric angles and mesh-based vertex angles, with emphasis on cranial-base and posterior maxillary/nasopharyngeal angles. Thresholds were screened using single-break segmented regression, and causal dose-response functions were estimated using generalized propensity score models stratified by sex and age. RESULTS: A total of 4,271 children contributed 4,907 temporally ordered within-child radiograph visit pairs (each pair links an earlier and a later visit; children with >/= 3 visits contribute multiple pairs). The median baseline A/N ratio was 0.601 (interquartile range, 0.549-0.652). Across 189 angles, segmented regression identified a reproducible breakpoint band around A/N approximately 0.62-0.69. Generalized propensity score analyses showed positive, approximately linear dose-response functions for multiple cranial-base and posterior maxillary/nasopharyngeal angles, with global slopes typically 10-25 degrees /year per 1.0 increase in A/N and 80th-20th percentile contrasts of about 1-4 degrees /year. Baseline two-group comparisons showed synchronous reductions of about 3 degrees in SNA (sella-nasion-A angle) and SNB (sella-nasion-B angle) in children with adenoid hypertrophy, with ANB (A-nasion-B angle) largely unchanged. CONCLUSION: Higher radiographic A/N ratios were associated with threshold-sensitive, age- and sex-dependent craniofacial remodeling. As a 2D radiographic surrogate, A/N does not replace endoscopic or functional assessment. Combining A/N with selected cephalometric angles may help identify children who warrant closer follow-up and endoscopic evaluation during sensitive growth windows. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Duan, Bo AU - Duan B AD - Department of Otorhinolaryngology-Head and Neck Surgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. FAU - Zhang, Hengci AU - Zhang H AD - Department of OtolaryngologyNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, No. 136, Zhongshan 2Nd Road, Yuzhong District, Chongqing, 400014, China. FAU - Liang, Jia AU - Liang J AD - Department of OtolaryngologyNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, No. 136, Zhongshan 2Nd Road, Yuzhong District, Chongqing, 400014, China. FAU - Chen, Wenxia AU - Chen W AUID- ORCID: 0000-0002-6942-0666 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. chen_wenxia@fudan.edu.cn. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260630 PL - Germany TA - Eur Arch Otorhinolaryngol JT - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JID - 9002937 SB - IM MH - Humans MH - Child MH - *Adenoids/pathology/diagnostic imaging MH - Male MH - Child, Preschool MH - Female MH - Longitudinal Studies MH - Cephalometry MH - *Nasopharynx/diagnostic imaging/pathology MH - Hypertrophy MH - China MH - Skull Base MH - *Maxillofacial Development OTO - NOTNLM OT - Adenoid hypertrophy OT - Adenoid-nasopharyngeal ratio OT - Cephalometry OT - Craniofacial growth OT - Generalized propensity score OT - Pediatric airway COIS- Declarations. Ethical approval: The study protocol was approved by the institutional review boards of the participating centers and was conducted in accordance with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. To preserve masking during peer review, the names of the institutions and approval numbers are not disclosed in this version. Consent to participate: Informed consent was obtained or waived in accordance with local regulations and institutional policies for studies using clinically indicated, routinely acquired imaging data. Consent to publish: Not applicable. The manuscript does not contain any individual person's data in any form (including individual images). Role of the funder/sponsor: Not applicable. Trial registration: Not applicable. Competing interests: The authors declare that they have no competing interests that are directly or indirectly related to the work submitted for publication. Conflict of interest: The authors declare that they have no conflict of interest. EDAT- 2026/07/01 10:11 MHDA- 2026/09/25 17:32 CRDT- 2026/07/01 00:13 PHST- 2025/12/21 00:00 [received] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/09/25 17:32 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 00:13 [entrez] AID - 10.1007/s00405-026-10387-6 [pii] AID - 10.1007/s00405-026-10387-6 [doi] PST - ppublish SO - Eur Arch Otorhinolaryngol. 2026 Sep;283(9):5791-5802. doi: 10.1007/s00405-026-10387-6. Epub 2026 Jun 30. PMID- 42380385 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260817 IS - 1573-2800 (Electronic) IS - 0004-0002 (Print) IS - 0004-0002 (Linking) VI - 55 IP - 5 DP - 2026 May TI - Perceived Waist-to-Hip Ratio Predicts Attractiveness, Age, and Parity Judgments in Pre-Contemporary European Portraits of Clothed Women. PG - 2027-2039 LID - 10.1007/s10508-026-03485-3 [doi] AB - Women with a lower waist-to-hip ratio (WHR) are consistently judged as more attractive, a finding replicated across diverse populations and methods. From an evolutionary perspective, this preference may reflect selection for cues of female reproductive potential, as WHR reliably tracks both age and parity. However, virtually all previous studies present nude or minimally clothed bodies in highly standardized conditions, leaving open whether WHR-based judgments generalize to more ecologically valid settings and whether they extend beyond attractiveness to the reproductive traits WHR is a cue of. We addressed both questions by analyzing 608 painted female figures from European portraits (1650-1950), depicting fully clothed women in visually complex and minimally sexualized settings. Online Prolific observers (N = 1,525) independently estimated the body shape, attractiveness, age, and likelihood of previous childbirth from either the body or the face of the painted characters. Perceived WHR strongly predicted all three trait judgments: lower WHR was associated with higher attractiveness, younger perceived age, and lower perceived likelihood of previous childbirth. These relationships persisted after controlling for posture, body orientation, perceived weight, perceived facial age, artistic school, and date of the artwork. Our findings show that WHR-based perceptual heuristics are not artefacts of the narrow stimulus conditions used in prior research but persist in visually complex, clothed, and historically diverse depictions of women. They further suggest that fashion styles that exaggerate WHR may have functioned as strategic amplifiers of reproductively relevant cues, with implications for theories of mate choice, social signaling, fashion history, and cultural evolution. CI - (c) 2026. The Author(s). FAU - Bovet, Jeanne AU - Bovet J AUID- ORCID: 0000-0002-3997-8837 AD - School of Psychology, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK. jeanne.bovet@northumbria.ac.uk. FAU - Truchard, Valentine AU - Truchard V AD - Institut Jean Nicod, Departement d'etudes Cognitives, Ecole Normale Superieure, Universite PSL, EHESS, CNRS, Paris, France. FAU - Touzeau, Charlotte AU - Touzeau C AUID- ORCID: 0009-0009-6117-0891 AD - Institut Jean Nicod, Departement d'etudes Cognitives, Ecole Normale Superieure, Universite PSL, EHESS, CNRS, Paris, France. FAU - Chevallier, Coralie AU - Chevallier C AUID- ORCID: 0000-0002-7358-4962 AD - Institut Jean Nicod, Departement d'etudes Cognitives, Ecole Normale Superieure, Universite PSL, EHESS, CNRS, Paris, France. FAU - Baumard, Nicolas AU - Baumard N AUID- ORCID: 0000-0002-1439-9150 AD - Institut Jean Nicod, Departement d'etudes Cognitives, Ecole Normale Superieure, Universite PSL, EHESS, CNRS, Paris, France. LA - eng GR - ANR-17-EURE-0017/Agence Nationale de la Recherche/ GR - ANR-10-IDEX-0001-02/Agence Nationale de la Recherche/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260630 PL - United States TA - Arch Sex Behav JT - Archives of sexual behavior JID - 1273516 SB - IM MH - Humans MH - Female MH - *Judgment MH - Adult MH - *Waist-Hip Ratio MH - *Beauty MH - *Parity MH - Age Factors MH - *Portraits as Topic/psychology MH - Young Adult MH - Middle Aged MH - Cues PMC - PMC13427934 OTO - NOTNLM OT - Age OT - Attractiveness OT - Body perception OT - Historical portraits OT - Parity OT - Reproductive cues COIS- Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. Ethical Approval: Approval was obtained from the ethics committee of Northumbria University. The procedures used in this study adhere to the tenets of the Declaration of Helsinki. EDAT- 2026/07/01 06:34 MHDA- 2026/08/01 00:36 PMCR- 2026/06/30 CRDT- 2026/07/01 00:02 PHST- 2025/10/10 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/04/01 00:00 [revised] PHST- 2026/08/01 00:36 [medline] PHST- 2026/07/01 06:34 [pubmed] PHST- 2026/07/01 00:02 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.1007/s10508-026-03485-3 [pii] AID - 3485 [pii] AID - 10.1007/s10508-026-03485-3 [doi] PST - ppublish SO - Arch Sex Behav. 2026 May;55(5):2027-2039. doi: 10.1007/s10508-026-03485-3. Epub 2026 Jun 30. PMID- 42379716 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 30 TI - Development and internal validation of a neonatal mortality risk prediction model for low birthweight neonates in public hospitals, North-West Ethiopia: a prospective follow-up study. PG - e120111 LID - 10.1136/bmjopen-2026-120111 [doi] LID - e120111 AB - OBJECTIVES: This study aimed to develop and internally validate a neonatal mortality risk prediction model for low birthweight (LBW) neonates in public hospitals of North-West Ethiopia. DESIGN: An institution-based prospective follow-up study. SETTING: The study was conducted in seven hospitals, comprising three general hospitals and four primary hospitals, between 14 February and 31 October 2025. The general hospitals, Injibara, Finote Selam and Pawi, provide level II neonatal intensive care services, whereas the primary hospitals, Dangila, Chagni, Jawi and Gimja Bet, provide level I newborn care services. These hospitals are situated in the Awi, West Gojjam and Metekel zones of the Amhara and Benishangul Gumuz regions in north-western Ethiopia. PARTICIPANTS: 955 LBW neonates were enrolled in the study. Neonates born outside health facilities were excluded if their birth weight was unknown, particularly those delivered by traditional birth attendants, as were neonates whose first recorded weight was obtained more than 24 hours after birth. Participants were selected using consecutive sampling and data were collected electronically using the KoboCollect mobile application. OUTCOME MEASURES: Data were analysed using R software V.4.4.3. Least Absolute Shrinkage and Selection Operator regression and multivariable logistic regression were used to identify predictors and develop a simplified risk score and nomogram. Model performance was evaluated in terms of discrimination and calibration, while internal validation was performed using bootstrapping. The clinical utility of the model was assessed using decision curve analysis (DCA). RESULTS: The final model included nine predictors: sepsis, perinatal asphyxia, respiratory distress syndrome, absence of exclusive breastfeeding, absence of Kangaroo Mother Care, gestational ages of 28 weeks to <32 weeks and 32 weeks to <37 weeks, and birth weights of <1000 g and 1000-1499 g. The original model demonstrated good discrimination, with an area under the curve of 84.2% (95% CI 81.5% to 86.9%). After internal validation, the simplified risk score and nomogram achieved areas under the curve of 83.85% and 83.5%, respectively. The model showed excellent calibration before and after validation. DCA indicated that the model provides meaningful clinical benefit. CONCLUSIONS: The nomogram and simplified risk score demonstrated excellent calibration and good discriminatory performance. Their application in clinical settings may improve early intervention and potentially reduce neonatal mortality in Ethiopia by enabling rapid, individualised mortality-risk prediction among LBW neonates. However, external validation in different settings is required. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Eshetu, Daniel Mulat AU - Eshetu DM AUID- ORCID: 0009-0007-1201-904X AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia danielmulat81@gmail.com. FAU - Kassa, Assefa Andargie AU - Kassa AA AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Ayele, Wolde Melese AU - Ayele WM AUID- ORCID: 0000-0003-4830-3599 AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Kassahun, Mulatu AU - Kassahun M AUID- ORCID: 0009-0005-2973-8142 AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Zeleke, Shashitu Tadele AU - Zeleke ST AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Anagaw, Betelhem Mekuriaw AU - Anagaw BM AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Molla, Mikias Getahun AU - Molla MG AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Sharew, Kalaab Esubalew AU - Sharew KE AUID- ORCID: 0000-0001-5524-7754 AD - Department of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Abeje, Birhanu Kassie AU - Abeje BK AD - Biomedical Sciences Education and Service Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. FAU - Ayalew, Chalachew Abiyu AU - Ayalew CA AUID- ORCID: 0009-0008-2376-8983 AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260630 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Infant, Newborn MH - *Infant, Low Birth Weight MH - Hospitals, Public MH - *Infant Mortality MH - Prospective Studies MH - Female MH - Risk Assessment/methods MH - Male MH - Follow-Up Studies MH - Infant MH - Risk Factors MH - Prediction Algorithms MH - Birth Weight MH - Logistic Models MH - ROC Curve PMC - PMC13331094 OTO - NOTNLM OT - EPIDEMIOLOGIC STUDIES OT - Ethiopia OT - Mortality OT - NEONATOLOGY COIS- Competing interests: None declared. EDAT- 2026/07/01 00:35 MHDA- 2026/07/01 18:34 PMCR- 2026/06/30 CRDT- 2026/06/30 21:03 PHST- 2026/07/01 18:34 [medline] PHST- 2026/07/01 00:35 [pubmed] PHST- 2026/06/30 21:03 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - bmjopen-2026-120111 [pii] AID - 10.1136/bmjopen-2026-120111 [doi] PST - epublish SO - BMJ Open. 2026 Jun 30;16(6):e120111. doi: 10.1136/bmjopen-2026-120111. PMID- 42379099 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261021 IS - 1879-1271 (Electronic) IS - 0268-0033 (Linking) VI - 138 DP - 2026 Aug TI - Exploring real-world lumbar posture behaviour. A whole day comparison of individuals with low back pain and healthy controls. PG - 106908 LID - S0268-0033(26)00163-4 [pii] LID - 10.1016/j.clinbiomech.2026.106908 [doi] AB - BACKGROUND: Previous research of lumbar posture on individuals with low back pain (LBP) has produced conflicting findings compared to control groups. This research has been limited by environmental or task constraints. Real-world postural behaviour across an entire day remains poorly understood. This study examined whole-day lumbar posture characteristics in people with and without LBP using wearable sensors. METHODS: 13 people with LBP and 11 healthy controls volunteered for this study. A three-accelerometer setup was used to measure real-world lumbar posture classifying sitting and standing. Data were normalised to individual maximum ranges. Differences in measures of mean posture, variability, fidgeting, and posture-use frequency distributions, were derived. FINDINGS: An average of 350 min of data per person was available for analysis. Overall, between group differences were small. LBP demonstrated more flexed posture use in standing and a more flexed sitting frequency distribution. INTERPRETATION: Real-world posture behaviour was similar between individuals with and without LBP. Where differences were determined they related to temporal components such as frequencies which are masked with traditional postural estimates. These findings suggest that posture-pain relationships may vary substantially between individuals, emphasising the need for person-specific analysis in future research. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - McClintock, Frederick A AU - McClintock FA AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. Electronic address: fmcclintock@bournemouth.ac.uk. FAU - Callaway, Andrew J AU - Callaway AJ AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. FAU - Clark, Carol J AU - Clark CJ AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. FAU - Munoz-Gomez, Elena AU - Munoz-Gomez E AD - Research Unit in Clinical Biomechanics (UBIC), Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, 46010, Valencia, Spain. FAU - Alqhtani, Raee S AU - Alqhtani RS AD - College of Applied Medical Science, Najran University, Najran, P.O. Box 1988, Saudi Arabia. FAU - Williams, Jonathan M AU - Williams JM AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. LA - eng PT - Comparative Study PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260629 PL - England TA - Clin Biomech (Bristol) JT - Clinical biomechanics (Bristol, Avon) JID - 8611877 SB - IM MH - *Posture/physiology MH - *Low Back Pain/physiopathology MH - *Lumbar Vertebrae/physiopathology MH - Case-Control Studies MH - Wearable Electronic Devices MH - Healthy Volunteers MH - Accelerometry/instrumentation MH - Sitting Position MH - Standing Position MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged OTO - NOTNLM OT - Discomfort OT - Ecological validity OT - Field-based OT - Lordosis OT - Provocation OT - Spine OT - Variability COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2026/07/01 00:35 MHDA- 2026/07/15 12:37 CRDT- 2026/06/30 18:09 PHST- 2025/11/13 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/07/15 12:37 [medline] PHST- 2026/07/01 00:35 [pubmed] PHST- 2026/06/30 18:09 [entrez] AID - S0268-0033(26)00163-4 [pii] AID - 10.1016/j.clinbiomech.2026.106908 [doi] PST - ppublish SO - Clin Biomech (Bristol). 2026 Aug;138:106908. doi: 10.1016/j.clinbiomech.2026.106908. Epub 2026 Jun 29. PMID- 42379026 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260724 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 268 DP - 2026 Aug TI - Physical activity and loneliness in rural left-behind children: The mediating roles of social anxiety and self-concept. PG - 107262 LID - S0001-6918(26)01063-2 [pii] LID - 10.1016/j.actpsy.2026.107262 [doi] AB - BACKGROUND: Loneliness is a prominent mental health concern among rural left-behind children in China, yet the psychological pathways through which physical activity may be related to loneliness remain underexplored. OBJECTIVE: This study explores the psychosocial pathways linking physical activity to loneliness in rural left-behind children, with particular focus on the chain-mediating effects of self-concept and social anxiety. METHODS: A sample of 540 Chinese rural left-behind children completed the scales that assessed loneliness, physical activity, social anxiety, and self-concept. SPSS 27.0 was used to conduct the common method bias test, reliability analysis, and correlation analysis. Mplus 8.3 was then employed to explore the mediating roles of social anxiety and self-concept within a chained mediation model. RESULTS: Common method bias was determined to be within acceptable limits for this study. Key findings include: (1) A negative correlation exists between physical activity and loneliness, with physical activity substantially correlated with loneliness (beta = -0.322); (2) Social anxiety partially mediated the relationship between physical activity and loneliness (beta = -0.117), accounting for 22.1% of the total effect; (3) Self-concept also partially mediated the relationship between physical activity and loneliness (beta = -0.132), representing 24.9% of the total effect; (4) A conspicuous chain mediating effect was observed through social anxiety and self-concept (beta = -0.013), accounting for 3.5% of the total effect (all p < 0.001). CONCLUSION: Physical activity is directly and indirectly associated with loneliness among RLBC, with social anxiety and self-concept serving as mediating variables in a chain mediating pathway. These findings are consistent with attachment theory in that higher physical activity is associated with lower loneliness, which may reflect alternative sources of social connection; the observed patterns suggest that school-based physical activity programs designed to address social anxiety and self-concept could be associated with lower loneliness, though this awaits testing in longitudinal or experimental research. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Peng, Dianhui AU - Peng D AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China; Department of Art, Beijing Sport University, Beijing, China. FAU - Li, Si AU - Li S AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Luo, Yipin AU - Luo Y AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Li, Xiaolin AU - Li X AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Long, Jiayi AU - Long J AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Chen, Jiaxi AU - Chen J AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Lu, Chunxia AU - Lu C AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. Electronic address: luchunxia@hunnu.edu.cn. FAU - Wang, Yujuan AU - Wang Y AD - Sports and Health Promotion, Hunan University of Finance and Economics, Changsha, Hunan, China. Electronic address: wangyujuan@hufe.edu.cn. LA - eng PT - Journal Article DEP - 20260630 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - *Loneliness/psychology MH - *Self Concept MH - Female MH - Male MH - Child MH - *Rural Population MH - China MH - *Exercise/psychology MH - *Anxiety/psychology OTO - NOTNLM OT - Left-behind children OT - Loneliness OT - Physical activity OT - Self-concept OT - Social anxiety COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Chunxia Lu reports financial support was provided by the Social Science General Project of Hunan Province. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/01 00:35 MHDA- 2026/07/24 06:35 CRDT- 2026/06/30 18:07 PHST- 2025/05/13 00:00 [received] PHST- 2026/06/05 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/07/24 06:35 [medline] PHST- 2026/07/01 00:35 [pubmed] PHST- 2026/06/30 18:07 [entrez] AID - S0001-6918(26)01063-2 [pii] AID - 10.1016/j.actpsy.2026.107262 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Aug;268:107262. doi: 10.1016/j.actpsy.2026.107262. Epub 2026 Jun 30. PMID- 42378256 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260926 IS - 2369-2960 (Electronic) IS - 2369-2960 (Linking) VI - 12 DP - 2026 Jun 30 TI - Comparison of Measured 24-Hour Urinary Salt Excretion With Spot Urine and 24-Hour Dietary Recall Estimates Among Adolescents and Parents: Cross-Sectional Study. PG - e85549 LID - 10.2196/85549 [doi] LID - e85549 AB - BACKGROUND: Hypertension, a leading cause of cardiovascular disease, is a significant public health challenge, with urban India reporting prevalence rates up to 40%. Excessive salt intake, averaging 8 to 11 g/day in India, far exceeds the World Health Organization-recommended limit of 5 g/day and is a key modifiable risk factor. While 24-hour urine collection is the gold standard for measuring 24-hour urinary excreted salt levels, its practicality in large-scale studies is limited, necessitating alternative methods such as spot urine sampling and dietary recall. OBJECTIVE: This study aimed to address current knowledge gaps by evaluating 24-hour urinary excretory salt levels across age groups and comparing the gold standard of 24-hour urinary salt excretion with estimates from spot urine samples and 24-hour dietary recalls among adolescents and their parents in Chandigarh, India. METHODS: A cross-sectional survey was conducted among 462 adolescents and 395 parents from public schools in Chandigarh, part of a cluster randomized controlled trial focused on reducing chronic disease risk factors. Twenty-four-hour urinary excreted salt levels were measured via 24-hour urine collection, spot urine samples were analyzed with the Kawasaki, Tanaka, and INTERSALT equations, and 2 nonconsecutive 24-hour dietary recalls using a correction factor of 0.9. Bland-Altman plots were used to assess agreement between methods. RESULTS: The mean 24-hour urinary excreted salt levels measured via 24-hour urine samples were 6.95 g/day (SD 0.24; 95% CI 6.48-7.42) for adolescents and 7.73 g/day (SD 0.3; 95% CI 7.18-8.28) for parents. Spot urine estimates showed variability, with the INTERSALT equation with potassium yielding the closest results to 24-hour measurements for parents (mean 8.12, SD 0.4 g/d; 95% CI 7.36-8.95) and adolescents (mean 7.97, SD 0.4 g/day; 95% CI 7.16-8.77). Dietary recall underestimated 24-hour urinary excreted salt levels for both groups (mean 4.15, SD 0.08 g/day for adolescents and mean 3.62, SD 0.08 g/day for parents). CONCLUSIONS: Spot urine sampling, particularly the INTERSALT with potassium equation, offers a feasible alternative to 24-hour urine collection for estimating population-level 24-hour urinary excreted salt levels among adolescents and adults in resource-limited settings. Dietary recall alone significantly underestimates intake and should be supplemented with objective measures. These findings support the use of tailored estimation methods based on age for improved hypertension management strategies in India. CI - (c) Sandeep Kaur, Akashdeep Singh Chauhan, Rajesh Kumar, Manmeet Kaur. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org). FAU - Kaur, Sandeep AU - Kaur S AUID- ORCID: 0000-0003-3170-6703 AD - Faculty of Medicine, Imperial College London, Hammersmith Campus, London, W120NN, United Kingdom, 44 7570297460. AD - Indian Institute of Public Health-Delhi, Public Health Foundation of India, New Delhi, India. AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. FAU - Chauhan, Akashdeep Singh AU - Chauhan AS AUID- ORCID: 0000-0001-6791-2221 AD - Indian Institute of Public Health-Delhi, Public Health Foundation of India, New Delhi, India. AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. FAU - Kumar, Rajesh AU - Kumar R AUID- ORCID: 0000-0001-9750-3437 AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. AD - Health Equity Action Learnings Foundation, Chandigarh, India. FAU - Kaur, Manmeet AU - Kaur M AUID- ORCID: 0000-0003-2450-3115 AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. AD - Health Equity Action Learnings Foundation, Chandigarh, India. LA - eng SI - CTRI/CTRI/2019/09/021452 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260630 PL - Canada TA - JMIR Public Health Surveill JT - JMIR public health and surveillance JID - 101669345 RN - 0 (Sodium Chloride, Dietary) SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - India/epidemiology MH - Female MH - *Sodium Chloride, Dietary/urine MH - *Urine Specimen Collection/methods MH - *Parents/psychology MH - Child MH - Adult MH - *Urinalysis/methods MH - *Mental Recall PMC - PMC13317844 OTO - NOTNLM OT - 24-hour urine collection OT - adolescents OT - cardiovascular diseases OT - chronic diseases OT - dietary recall OT - excretory salt OT - hypertension OT - spot urine sampling OT - urinary excreted salt levels COIS- Conflicts of Interest: None declared. EDAT- 2026/06/30 22:37 MHDA- 2026/06/30 22:38 PMCR- 2026/06/30 CRDT- 2026/06/30 13:42 PHST- 2025/10/10 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/30 22:38 [medline] PHST- 2026/06/30 22:37 [pubmed] PHST- 2026/06/30 13:42 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - v12i1e85549 [pii] AID - 85549 [pii] AID - 10.2196/85549 [doi] PST - epublish SO - JMIR Public Health Surveill. 2026 Jun 30;12:e85549. doi: 10.2196/85549. PMID- 42378255 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Study Protocol for "Exploring the safety and therapeutic potential of psilocybin in the treatment of anorexia nervosa in adolescents and young adults". PG - e0352246 LID - 10.1371/journal.pone.0352246 [doi] LID - e0352246 AB - BACKGROUND: Anorexia nervosa (AN) is a severe psychiatric disorder with high morbidity, mortality, and relapse rates, most commonly emerging during adolescence. Despite specialized psychological and nutritional treatments, outcomes remain suboptimal, with high rates of relapse and chronicity. Psilocybin has been investigated with preliminary efficacy in other psychiatric conditions characterized by rigidity and treatment resistance, but clinical evidence in AN-particularly in adolescents-is limited. OBJECTIVE: The psiAN study aims to evaluate the safety, tolerability, and feasibility of psilocybin therapy combined with psychological support in adolescents and young adults with relapsing AN, while exploring clinical, experiential, and neurobiological correlates of change. METHODS: A phase IIa, open-label, randomized controlled trial enrolling individuals aged 16-35 years with DSM-5 AN and a history of relapse. Participants are randomized to receive either two administrations of psilocybin (25 mg) with manualized psychological support plus treatment as usual (TAU), or TAU alone. Primary outcomes focus on safety and tolerability, assessed through adverse events, psychiatric monitoring, and medical parameters measured from first dosing to primary endpoint. Secondary outcomes include change in eating disorder symptom severity, relapse composite measures, mood, well-being, personality traits from baseline to primary endpoint with follow-up to 12 months. Functional magnetic resonance imaging (fMRI) and peripheral brain-derived neurotrophic factor are included as exploratory mechanistic measures. fMRI will evaluate pre- to post-intervention changes in structural and functional connectivity and task-related responses during a simplified Monetary Incentive Delay task (MIDT) and a Calorie-Cue Task (CCT). ClinicalTrials.gov Identifier: NCT07169747. ETHICS AND DISSEMINATION: The study follows Good Clinical Practice (GCP), the Declaration of Helsinki, and EU Clinical Trials Regulation requirements, with staged inclusion of adolescents (16-17-year-olds) after a safety board review of adult data (18-35-year-olds). This protocol was prepared with reference to the SPIRIT 2025 guidelines (Chan et al., 2025) to enhance transparency and inform future trials. CI - Copyright: (c) 2026 Sjostrom et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sjostrom, David AU - Sjostrom D AUID- ORCID: 0000-0003-0004-1892 AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. FAU - Schau Ryback, Olea AU - Schau Ryback O AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Adult Psychiatry, Skane University Hospital, Lund, Sweden. FAU - Claesdotter Knutsson, Emma AU - Claesdotter Knutsson E AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Skane University Hospital, Lund, Sweden. FAU - Kajonius, Petri AU - Kajonius P AD - Department of Psychology, Lund University, Lund, Sweden. FAU - Jensen Sonden, Oskar AU - Jensen Sonden O AD - Department of Psychology, Lund University, Lund, Sweden. FAU - Carlbring, Per AU - Carlbring P AUID- ORCID: 0000-0002-2172-8813 AD - Department of Psychology, Stockholm University, Stockholm, Sweden. AD - School of Psychology, Korea University, Seoul, South Korea. FAU - Bjorkstrand, Johannes AU - Bjorkstrand J AD - Department of Psychology, Lund University, Lund, Sweden. FAU - Movahed Rad, Pouya AU - Movahed Rad P AUID- ORCID: 0000-0003-2041-3550 AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Adult Psychiatry, Skane University Hospital, Lund, Sweden. LA - eng SI - ClinicalTrials.gov/NCT07169747 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260630 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 2RV7212BP0 (Psilocybin) RN - 0 (Hallucinogens) SB - IM MH - Humans MH - *Anorexia Nervosa/drug therapy/psychology MH - *Psilocybin/therapeutic use/adverse effects/administration & dosage MH - Adolescent MH - Young Adult MH - Randomized Controlled Trials as Topic MH - Adult MH - Female MH - Clinical Trials, Phase II as Topic MH - Treatment Outcome MH - *Hallucinogens/therapeutic use/adverse effects PMC - PMC13318048 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/30 22:37 MHDA- 2026/06/30 22:38 PMCR- 2026/06/30 CRDT- 2026/06/30 13:34 PHST- 2026/05/18 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/30 22:38 [medline] PHST- 2026/06/30 22:37 [pubmed] PHST- 2026/06/30 13:34 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - PONE-D-26-20879 [pii] AID - 10.1371/journal.pone.0352246 [doi] PST - epublish SO - PLoS One. 2026 Jun 30;21(6):e0352246. doi: 10.1371/journal.pone.0352246. eCollection 2026. PMID- 42377367 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260820 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 43 IP - Spec No4 DP - 2026 Jul 20 TI - EnComCol Study on the diet of children and young people at home and in schools: design and methodology. PG - 41-45 LID - 10.20960/nh.06963 [doi] AB - EnComCol is an observational, crosssectional, multicentre study assessing diet in Spanish children and adolescents (6-17 years) by comparing intake at home with that in the school canteen. It is framed by the continuing burden of childhood overweight/obesity and Royal Decree 315/2025, which harmonises criteria for school menus and portions. The main aim is to identify differences in foods, beverages and nutrient intake according to canteen use, school ownership (public, charter, or private) and residence across six mainland regions, considering six daily mealtimes eating occasions. The sample comprises 1,000 urban participants, balanced by age (50 % 6-11; 50 % 12-17) and sex, with quotas for school type (75 % public, 20 % charter, 5 % private) and geographic distribution using Nielsen areas. For ages 6-11, quotas ensure a 50/50 split between canteen users and nonusers. Methods include a structured 24 hours recall dietary record plus sociodemographic, anthropometric and lifestyle variables. Data collection has three phases: recruitment and a technology-assisted interview; a food diary with telephone interview; and researcher telephone validation, with digital coding and nutrient conversion using updated food-composition tables. Analyses will use descriptive and inferential statistics, mean/proportion comparisons, multivariable models and stratification by age, sex, school type, canteen use and region (p < 0.05). Findings will enable direct comparison with prior research and quantification of critical nutrients (saturated fat, sugars and salt) across contexts. FAU - Urrialde, Rafael AU - Urrialde R AD - Department of Genetics, Physiology and Microbiology. Faculty of Biological Sciences. Universidad Complutense de Madrid. Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universid. FAU - Modrego, Javier AU - Modrego J AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Gesteiro, Eva AU - Gesteiro E AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Zapico, Augusto G AU - Zapico AG AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Lopez Flores, Jessica AU - Lopez Flores J AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Gonzalez-Gross, Marcela AU - Gonzalez-Gross M AD - ImFINE Research Group, Health and Human Performance Department, Faculty of Physical Activity and Sport Sciences, Universidad Politecnica de Madrid, 28040 Madrid. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study TT - Estudio EnComCol sobre alimentacion en poblacion infantil y juvenil en el hogar y colegios: diseno y metodologia. PL - Spain TA - Nutr Hosp JT - Nutricion hospitalaria JID - 9100365 SB - IM MH - Humans MH - Child MH - Female MH - *Schools MH - Male MH - Adolescent MH - *Diet MH - Cross-Sectional Studies MH - Spain/epidemiology MH - Research Design MH - Diet Records OTO - NOTNLM OT - Comedor escolar. Registro dietetico de 24 horas. Registro estilo de vida. Nutrientes criticos. Ninos. Adolescentes. EDAT- 2026/06/30 16:10 MHDA- 2026/07/20 06:38 CRDT- 2026/06/30 10:53 PHST- 2026/07/20 06:38 [medline] PHST- 2026/06/30 16:10 [pubmed] PHST- 2026/06/30 10:53 [entrez] AID - 10.20960/nh.06963 [doi] PST - ppublish SO - Nutr Hosp. 2026 Jul 20;43(Spec No4):41-45. doi: 10.20960/nh.06963. PMID- 42376979 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 2544-4646 (Electronic) IS - 1733-1331 (Print) IS - 1733-1331 (Linking) VI - 75 IP - 2 DP - 2026 Jun 1 TI - Longitudinal Changes in Selected Gut Microorganisms During Gluten-Free Diet in Pediatric Coeliac Disease. PG - 195-209 LID - 10.33073/pjm-2026-017 [doi] AB - Alterations in gut microbiota have been reported in coeliac disease (CeD). However, longitudinal evidence distinguishing disease-related effects from diet-driven changes after gluten-free diet initiation remains scarce, particularly in pediatric cohorts. The present study aimed to evaluate time-dependent changes in selected intestinal microorganisms in children with CeD before and during adherence to a gluten-free diet and to compare these findings with those of healthy controls. Microbial DNA isolates from stool samples of pediatric patients with CeD (n = 24) and healthy children (n = 24) were analyzed by quantitative real-time PCR. Samples from CeD patients were categorized into four time points: pre-diet, 6-month, 1-year, and 2-year follow-up. The healthy controls were assessed once. The prevalence and microbial load of selected microorganisms were evaluated. Bifidobacterium spp. remained highly prevalent across all time points, although their abundance varied significantly over follow-up, with the lowest levels at one year and higher levels at two years, comparable to those in controls. The prevalence of Candida tropicalis increased significantly during dietary treatment, reaching levels similar to those of healthy children after two years. Saccharomyces cerevisiae showed a gradual rise in prevalence and abundance, whereas Methanobrevibacter smithii remained infrequent with low and fluctuating microbial load. The duration of adherence to a gluten-free diet appears to influence gut microbial profiles in pediatric CeD. The selected gut microbiota microorganisms' assessment may serve as a complementary tool for understanding intestinal adaptation during dietary treatment, however, its routine clinical application requires further validation. CI - (c) 2026 Aleksandra Zieba et al. FAU - Zieba, Aleksandra AU - Zieba A AD - 1Student of Dietetics, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland. FAU - Drozdz, Kamil AU - Drozdz K AD - 2Department of Molecular Medical Microbiology, Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland. FAU - Krawczyk, Agnieszka AU - Krawczyk A AD - 2Department of Molecular Medical Microbiology, Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland. LA - eng PT - Journal Article DEP - 20260629 PL - Poland TA - Pol J Microbiol JT - Polish journal of microbiology JID - 101229003 SB - IM MH - Humans MH - *Celiac Disease/microbiology/diet therapy MH - *Diet, Gluten-Free MH - Child MH - *Gastrointestinal Microbiome MH - Male MH - Female MH - Feces/microbiology MH - Child, Preschool MH - *Bacteria/classification/genetics/isolation & purification MH - Longitudinal Studies MH - Adolescent PMC - PMC13446153 OTO - NOTNLM OT - coeliac disease OT - gluten-free diet OT - gut microbiota OT - pediatric patients OT - qPCR COIS- Conflict of interest The authors do not report any financial or personal connections with other persons or organizations, which might negatively affect the contents of this publication and/or claim authorship rights to this publication. EDAT- 2026/06/30 16:10 MHDA- 2026/08/06 12:37 PMCR- 2026/06/29 CRDT- 2026/06/30 08:14 PHST- 2026/02/12 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/08/06 12:37 [medline] PHST- 2026/06/30 16:10 [pubmed] PHST- 2026/06/30 08:14 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - pjm-2026-017 [pii] AID - 10.33073/pjm-2026-017 [doi] PST - epublish SO - Pol J Microbiol. 2026 Jun 29;75(2):195-209. doi: 10.33073/pjm-2026-017. eCollection 2026 Jun 1. PMID- 42376369 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 2174-0852 (Electronic) IS - 1697-2600 (Print) IS - 1697-2600 (Linking) VI - 26 IP - 2 DP - 2026 Apr-Jun TI - Accelerometer-derived movement phenotypes and adolescent mental health in pediatric obesity: A causal machine-learning study. PG - 100704 LID - 10.1016/j.ijchp.2026.100704 [doi] LID - 100704 AB - BACKGROUND: Children with overweight or obesity are at elevated risk for later-life mental health challenges, but the role of accelerometer-derived waking movement behaviors remains uncertain. Thus, we examined longitudinal associations of sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous-intensity physical activity (MVPA) at age 7 with later-life internalizing and externalizing problems. METHOD: We used data from the UK Millennium Cohort Study, focusing on children with overweight or obesity at age 7 who had valid accelerometer data and a complete set of predefined analytic variables (N = 858). Exposures were average daily minutes of SB, LPA, and MVPA. Outcomes were parent-reported Strengths and Difficulties Questionnaire-based internalizing and externalizing problems scores at ages 11 and 14. A generalized random forests approach was used to estimate average treatment effects (ATEs) and conditional average treatment effects (CATEs), adjusted for relevant demographic, socioeconomic, body mass index, parental distress, baseline mental health, and co-occurring movement intensities; day-of-week activity-pattern variables were used as exploratory candidate moderators. RESULTS: Estimated ATEs were small. After applying the Benjamini-Hochberg false-discovery-rate (FDR) correction across the 12 primary exposure-outcome tests, only the association between higher SB and lower internalizing problems at age 11 remained statistically significant (ATE = -0.013 SDQ points per additional min/day; 95% CI, -0.019 to -0.007; q < 0.001). No other pathway survived FDR correction, and other nominal or directionally suggestive estimates were interpreted as exploratory. CATE summaries and calibration tests provided limited evidence of reproducible heterogeneity. CONCLUSIONS: Accelerometer-derived waking movement behaviors at age 7 were associated with later SDQ problems scores in small and outcome-specific ways among children with overweight or obesity. Since the study is based on observational data and relies on measured-confounder assumptions, the findings should be interpreted cautiously, and as model-based estimates rather than definitive causal evidence. CI - (c) 2026 Published by Elsevier B.V. FAU - Pan, Siyu AU - Pan S AD - School of psychology, Wuhan Sports University, Wuhan, China. FAU - Wang, Peng AU - Wang P AD - School of psychology, Wuhan Sports University, Wuhan, China. AD - Department of Language, Literature, and Communication, Faculty of Humanities, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, the Netherlands. AD - Department of Psychology, Education, and Child Studies, Erasmus University Rotterdam, Rotterdam, P.O. Box 1738, the Netherlands. FAU - Herold, Fabian AU - Herold F AD - Department of Physiology, Faculty of Medicine, HMU Health and Medical University Erfurt, Erfurt, Thuringia 99089, Germany. FAU - Heath, Matthew AU - Heath M AD - School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, 1151 Richmond St, London, ON N6A 3K7, Canada. AD - Graduate Program in Neuroscience, University of Western Ontario, 1151 Richmond St, London, ON N6A 3K7, Canada. AD - Canadian Centre for Activity and Aging, University of Western Ontario, 1201 Western Rd, London, ON, N6G 1H1 Canada. FAU - Lee, Edmund Wei Jian AU - Lee EWJ AD - Department of Media and Communication, College of Liberal Arts and Social Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China. FAU - Law, Effie Lai-Chong AU - Law EL AD - Department of Computer Science (Human-Computer Interaction Group), Durham University, Durham, UK. FAU - Lowe, Cassandra J AU - Lowe CJ AD - Department of Psychology, University of Exeter, UK. FAU - Werneck, Andre AU - Werneck A AD - Center for Epidemiological Research in Nutrition and Health, Department of Nutrition, School of Public Health, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Gerber, Markus AU - Gerber M AD - Department of Sport, Exercise and Health, Faculty of Medicine, University of Basel, Grosse Allee 6, Basel 4052, Switzerland. FAU - Moreau, David AU - Moreau D AD - School of Psychology and Centre for Brain Research, University of Auckland, Auckland 1030 New Zealand. FAU - Mavilidi, Myrto AU - Mavilidi M AD - Faculty of Education, Southern Cross University, Lismore, Australia. AD - Physical Activity, Sport and Exercise (PASER) Research Theme, Southern Cross University, Lismore, Australia. FAU - Paas, Fred AU - Paas F AD - Department of Psychology, Education, and Child Studies, Erasmus University Rotterdam, Rotterdam, P.O. Box 1738, the Netherlands. AD - School of Education, University of New South Wales, Sydney, NSW 1466, Australia. FAU - Hallgren, Mats AU - Hallgren M AD - Department of Public Health Sciences, Karolinska Institutet, Nobels vag 12A, Stockholm 17177, Sweden. FAU - Xu, Xia AU - Xu X AD - School of psychology, Wuhan Sports University, Wuhan, China. FAU - Zou, Liye AU - Zou L AD - School of psychology, Wuhan Sports University, Wuhan, China. LA - eng PT - Journal Article DEP - 20260620 PL - Spain TA - Int J Clin Health Psychol JT - International journal of clinical and health psychology : IJCHP JID - 101237969 PMC - PMC13312474 OTO - NOTNLM OT - Accelerometry OT - Causal machine learning OT - Digital phenotyping OT - Mental health OT - Pediatric obesity OT - Wearable sensors COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/20 CRDT- 2026/06/30 05:27 PHST- 2026/04/04 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:27 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - S1697-2600(26)00040-2 [pii] AID - 100704 [pii] AID - 10.1016/j.ijchp.2026.100704 [doi] PST - ppublish SO - Int J Clin Health Psychol. 2026 Apr-Jun;26(2):100704. doi: 10.1016/j.ijchp.2026.100704. Epub 2026 Jun 20. PMID- 42376252 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Sense of Coherence in patients with stable schizophrenia: multidimensional determinants from a cross-sectional study of 438 inpatients in Guangzhou, China. PG - 1750488 LID - 10.3389/fpsyt.2026.1750488 [doi] LID - 1750488 AB - INTRODUCTION: Schizophrenia, a chronic psychiatric disorder, profoundly affects social functioning and quality of life. The Sense of Coherence (SOC), a core construct in salutogenic theory, plays a pivotal role in stress coping and recovery outcomes. While SOC has been studied in general populations, its determinants in stabilized schizophrenia inpatients remain underexplored. This study comprehensively investigated the Sense of Coherence (SOC) profile among stabilized schizophrenia inpatients by assessing its current status, exploring the interrelationships between SOC and demographic factors/Big Five personality traits (CBF-PI)/social support (SSRS), and identifying factors associated with SOC to inform potential personalized resilience-enhancing interventions. Findings may guide clinical strategies to enhance resilience and mental health recovery and potentially facilitate functional recovery in this population. PATIENTS AND METHODS: A cross-sectional study was conducted at a Guangzhou tertiary psychiatric hospital with 438 stabilized schizophrenia inpatients from November 2024 to February 2025. Data collection included demographic/clinical variables, Chinese Big Five Personality Inventory (CBF-PI), 13-item Sense of Coherence Scale (SOC-13), and the Social Support Rating Scale (SSRS). Statistical analyses were performed using SPSS version 27.0. Descriptive statistics were used to summarize the data and independent-samples t-tests and one-way analysis of variance (ANOVA) were employed to compare SOC scores across demographic and clinical groups. Pearson correlation analysis was conducted to examine the relationships between personality traits, social support, and sense of coherence and multiple linear regression analysis was utilized to identify independent factors influencing sense of coherence (P < 0.05). RESULT: The mean SOC score among the 438 stabilized schizophrenia inpatients was 53.35 +/- 11.81. SOC correlated positively with all five dimensions of CBF-PI-B (P < 0.05), as well as subjective social support (P < 0.01), while showing inverse correlations with objective support (p < 0.01) and support utilization subscales (P < 0.01), Multiple regression identified personal income(yes), frequency of physical activity (>/=3 times/week), and primary caregiver (Children) as significant SOC predictors. CONCLUSION: This study demonstrates that stabilized schizophrenia inpatients in a tertiary psychiatric setting exhibit generally lower Sense of Coherence (SOC) levels compared with healthy normative values and moderately lower than several outpatient schizophrenia samples. Higher SOC was significantly associated with having a personal income, frequent physical activity (>/=3 times/week), having children as primary caregivers, and Chinese Big Five Personality traits. Notably, while subjective support was positively correlated with SOC, objective support and support utilization showed negative associations. Given the moderate internal consistency of the SSRS (Cronbach's alpha = 0.626), the differential associations with social support dimensions should be interpreted cautiously. Concurrently, personality traits are relatively stable, their associations with SOC may inform indirect supportive strategies leveraging existing strengths rather than direct modification. These findings underscore the potential value of tailored interventions that enhance subjective support, promote structured recreational activities, and foster patients' perceived coping resources. Further cross-sectional and longitudinal outpatient studies are warranted to validate these results and elucidate the mechanisms underlying the support paradox. CI - Copyright (c) 2026 Liang, Niu, Huang, Chen, Wu, Chen, Liu, Shi and Zeng. FAU - Liang, Rongyu AU - Liang R AD - Department of Geriatric Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. FAU - Niu, Zangrui AU - Niu Z AD - School of Nursing, Guangzhou Medical University, Guangzhou, China. FAU - Huang, Yuanyuan AU - Huang Y AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Department of Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. AD - Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. FAU - Chen, Xiezhen AU - Chen X AD - School of Nursing, Guangzhou Medical University, Guangzhou, China. FAU - Wu, Fengchun AU - Wu F AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Department of Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. AD - Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. FAU - Chen, Xiaodong AU - Chen X AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Chronic Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Liu, Cuixia AU - Liu C AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Chronic Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Shi, Xiaolei AU - Shi X AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Cerebrovascular Disease Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Zeng, Gang AU - Zeng G AD - Nursing Department, Guangzhou Chest Hospital Affiliated to Guangdong Pharmaceutical University, Guangzhou, China. AD - State Key Laboratory of Respiratory Disease, Guangzhou, China. AD - Institute of Tuberculosis, Guangzhou Medical University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260615 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13311124 OTO - NOTNLM OT - Big Five Personality OT - Sense of Coherence OT - inpatients OT - schizophrenia OT - social support COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:25 PHST- 2025/12/18 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:25 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1750488 [doi] PST - epublish SO - Front Psychiatry. 2026 Jun 15;17:1750488. doi: 10.3389/fpsyt.2026.1750488. eCollection 2026. PMID- 42376024 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Characteristics, predictors, and management of post-extubation dysphagia in critically Ill children: a scoping review. PG - 1854127 LID - 10.3389/fped.2026.1854127 [doi] LID - 1854127 AB - BACKGROUND: Post-extubation dysphagia (PED) is a common complication in critically ill children, associated with aspiration, malnutrition, and prolonged hospitalization. Standardized pediatric-specific assessment and management pathways are lacking, and published studies show substantial heterogeneity in diagnostic criteria, assessment timing, and intervention strategies. OBJECTIVE: This scoping review maps available evidence on pediatric PED, addressing: (1) incidence and clinical characteristics; (2) categories and effect sizes of independent predictors; and (3) the current state of prediction tools, bedside screening instruments, and management strategies. METHODS: Nine databases were searched systematically-PubMed, Embase, Cochrane Library, Web of Science, CINAHL, CNKI, Wanfang, VIP, and CBM-with a search cutoff of 12 March 2026. Fifteen studies were included, encompassing cohort studies, randomized controlled trials, quasi-experimental studies, and scale-development studies. Data were synthesized narratively following the JBI scoping review methodological framework. RESULTS: Included studies were published between 2018 and 2026; 73.3% (11/15) appeared after 2022, originating primarily from mainland China (n = 10) and Brazil (n = 3). The clinical apparent incidence ranged from 28.36% to 68.94%. No included bedside assessment instrument was validated against VFSS or FEES,representing a central methodological gap in the current evidence base.Independent predictors were categorized into three evidence tiers: Tier 1: intubation duration, age, and IWS; Tier 2: neurological comorbidities and number of intubations >/=2; Tier 3:delirium.The CRISPED score is the only prediction tool with temporal internal validation (C-statistic 0.85-0.86). No assessment instrument has been validated against an instrumental gold standard. Interventions centered on oral motor training, with no standardization in frequency, intensity, or multidisciplinary integration. CONCLUSION: Pediatric PED incidence is high and core risk factors have been repeatedly reported across multiple multivariable models, but the field shows substantial heterogeneity in diagnostic definitions, assessment tools, and intervention protocols. The absence of instrumental validation for bedside assessment tools is the central limitation. Key gaps include the absence of gold-standard diagnostic accuracy studies, externally validated prediction models, and standardized intervention pathways. Future research should prioritize multicenter prospective studies to unify diagnostic criteria, develop age-appropriate bedside screening tools, and establish a nurse-led multidisciplinary management framework. SYSTEMATIC REVIEW REGISTRATION: Open Science Framework (OSF), identifier doi: 10.17605/OSF.IO/XSJ9B. CI - (c) 2026 Xue, Zhang, Zhao, Hu, Ju, Sun, Zhang, Zhang, Yang and Guan. FAU - Xue, Yaokang AU - Xue Y AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. AD - School of Nursing, Jilin University, Changchun, China. FAU - Zhang, Baorong AU - Zhang B AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Zhao, Xiaoshuang AU - Zhao X AD - Department of Nursing, The First Hospital of Jilin University, Changchun, China. FAU - Hu, Lili AU - Hu L AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Ju, Liting AU - Ju L AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. AD - School of Nursing, Jilin University, Changchun, China. FAU - Sun, Hairui AU - Sun H AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Zhang, Dan AU - Zhang D AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Zhang, Jiping AU - Zhang J AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Yang, Yuxuan AU - Yang Y AD - School of Nursing, Jilin University, Changchun, China. FAU - Guan, Ruixin AU - Guan R AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260615 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13311104 OTO - NOTNLM OT - management strategies OT - pediatric intensive care OT - pediatrics OT - post-extubation dysphagia OT - predictors OT - scoping review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:22 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:22 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/fped.2026.1854127 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 15;14:1854127. doi: 10.3389/fped.2026.1854127. eCollection 2026. PMID- 42375697 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 2673-4842 (Electronic) IS - 2673-4842 (Linking) VI - 7 DP - 2026 TI - Identifying dietary patterns and their association with oral health behaviors in young children: a parent-based cross-sectional study in Lithuania. PG - 1844389 LID - 10.3389/froh.2026.1844389 [doi] LID - 1844389 AB - BACKGROUND: Children's oral health and nutrition are interconnected, jointly influencing growth, oral development, and disease prevention such as caries. Despite this connection, they are often addressed separately in research and practice, underscoring the need for validated parental assessment tools that support integrated and interdisciplinary prevention strategies. METHODS: This cross-sectional study examined underlying dietary patterns among 420 children aged 5-12 years in Kaunas, Lithuania, based on parental reports. Data were collected as part of a broader investigation of oral health behavior (OHB) and knowledge. Children's consumption habits were assessed using 17 structured dietary items, which were further used to adapt nutritional assessment subscales. Ethical approval was obtained from Kaunas Kolegija HEI. Exploratory factor analysis (EFA) was conducted to identify underlying dietary dimensions, and associations with sociodemographic variables and OHB were examined using correlation and regression analyses. RESULTS: EFA revealed a three-factor model explaining 40.30% of total variance, comprising: "recommended healthy foods" (e.g., fruits, vegetables), "inappropriate drinks and snacks" (e.g., sugary beverages), and "dairy products." Dietary measures were not associated with parents' age, gender, or self-perceived nutrition knowledge. Parents' education type was positively associated with "dietary" and "recommended healthy foods", while children's age showed negative associations with these variables, indicating less healthy dietary patterns in older children. OHB was positively associated with "recommended healthy foods", "dietary", and fruit and vegetable intake, but negatively associated with inappropriate drinks and snacks. Regression analysis revealed that consumption of "recommended healthy foods" and "parental success in ensuring healthy eating" as significant independent predictors of optimal OHB. CONCLUSIONS: These findings provide empirical support a multidimensional, parent-based dietary assessment framework that captures distinct eating patterns relevant to oral health. Integrating such tools into oral health promotion may enhance early prevention strategies by linking dietary behaviors with oral hygiene practices in a structured and evidence-based manner. CI - (c) 2026 Buunk-Werkhoven, Tamuliene, Dailidaite and Maciuliene. FAU - Buunk-Werkhoven, Yvonne A B AU - Buunk-Werkhoven YAB AD - Faculty of Medicine, Oral Health Department, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. FAU - Tamuliene, Rasa AU - Tamuliene R AD - Faculty of Medicine, Oral Health Department, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. FAU - Dailidaite, Evelina AU - Dailidaite E AD - Faculty of Medicine, Department of Medical Technologies and Dietetics, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. FAU - Maciuliene, Daiva AU - Maciuliene D AD - Faculty of Medicine, Oral Health Department, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20260615 PL - Switzerland TA - Front Oral Health JT - Frontiers in oral health JID - 9918227262706676 PMC - PMC13311115 OTO - NOTNLM OT - Lithuania OT - health promotion OT - oral health and consumption habits OT - parental influence OT - pre- and primary school children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:19 PHST- 2026/03/31 00:00 [received] PHST- 2026/05/06 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:19 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/froh.2026.1844389 [doi] PST - epublish SO - Front Oral Health. 2026 Jun 15;7:1844389. doi: 10.3389/froh.2026.1844389. eCollection 2026. PMID- 42375325 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Development and validation of a clinical prediction model for poor ovarian response in assisted reproductive technology. PG - 1732869 LID - 10.3389/fendo.2026.1732869 [doi] LID - 1732869 AB - OBJECTIVE: The aim of this study was to develop and validate a predictive model for poor ovarian response (POR) in patients undergoing Assisted Reproductive Technology (ART). METHODS: This retrospective cohort study included 1,789 patients who underwent IVF/ICSI with a GnRH antagonist protocol at the reproductive medicine center of Shenyang Women's and Children's Hospital between January 2020 and December 2023. Data from January 2020 to April 2023 were used for model development, and data from May 2023 to December 2023 was used for validation. Clinical and ovarian reserve markers were collected. Four prediction models were developed and compared: (1) logistic regression with stepwise selection, (2) full-variable logistic regression, (3) LASSO regression with the minimum lambda (lambda_min) criterion, and (4) LASSO regression with the 1-standard error (1-SE) rule. The optimal model was selected based on discrimination (area under the receiver operating characteristic curve, AUC), calibration, and Brier score. RESULTS: The final model, based on stepwise logistic regression, identified AMH, basal FSH, BMI, and antral follicle count as significant predictors of POR. The model exhibited high discriminatory ability and good calibration across the training, internal validation, and test datasets. The nomogram developed from this model provides an easy-to-use tool for individualized risk prediction, enabling clinicians to optimize treatment strategies for patients at risk of POR. CONCLUSION: This study provides a comprehensive predictive model for POR in ART, incorporating a wide range of clinical and ovarian reserve markers. The stepwise logistic regression model offers superior predictive accuracy and clinical utility, making it a valuable tool for personalized ART management. The nomogram developed enhances decision-making in ART by offering an intuitive, evidence-based method for predicting POR risk. CI - Copyright (c) 2026 Xin, Cheng, Hu, Guo, Li, Zhao and Guo. FAU - Xin, Xin AU - Xin X AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Cheng, Zhaoxia AU - Cheng Z AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Hu, Ting AU - Hu T AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Guo, Yi AU - Guo Y AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Li, Nan AU - Li N AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Zhao, Junbo AU - Zhao J AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Guo, Shuaishuai AU - Guo S AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260615 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 80497-65-0 (Anti-Mullerian Hormone) SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - *Reproductive Techniques, Assisted MH - *Ovarian Reserve/physiology MH - Adult MH - *Ovulation Induction/methods MH - Prediction Algorithms MH - Anti-Mullerian Hormone/blood MH - Logistic Models MH - Nomograms MH - Fertilization in Vitro PMC - PMC13310710 OTO - NOTNLM OT - assisted reproductive technology OT - clinical prediction model OT - nomogram OT - ovarian reserve markers OT - poor ovarian response COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:15 PHST- 2025/10/26 00:00 [received] PHST- 2026/03/18 00:00 [revised] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:15 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/fendo.2026.1732869 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jun 15;17:1732869. doi: 10.3389/fendo.2026.1732869. eCollection 2026. PMID- 42374927 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 83 IP - 3 DP - 2026 Sep TI - Safety of infant milks: Contamination with cereulide. A commentary by ESPGHAN (European Society for Paediatric Gastroenterology, Hepatology, and Nutrition). PG - 371-373 LID - 10.1002/jpn3.70488 [doi] AB - Since late 2025, precautionary recalls of specific infant and follow-on formula batches in Europe have occurred due to contamination with cereulide, a heat- and acid-stable emetic toxin produced by certain Bacillus cereus strains. Contamination was traced to arachidonic acid (ARA)-containing algal oil from a single supplier; no viable bacteria were detected in the affected products. The European Food Safety Authority established a conservative acute reference dose for infants, and available monitoring data indicate that detected concentrations were generally low and unlikely to pose significant health risks, although some batches may have exceeded precautionary thresholds. This commentary reviews the toxicological background, current risk assessment, analytical challenges, and clinical implications. While cereulide should not be present beyond unavoidable trace levels in infant formula, risk management must remain proportionate and avoid promoting nutritionally inadequate substitutes. Ensuring validated analytical surveillance, stringent raw material control, transparent communication, and continued provision of appropriately regulated formulas containing recommended long-chain polyunsaturated fatty acids, including docosahexaenoic acid (DHA) and ARA, is essential to safeguard infant health and maintain public confidence. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Haiden, Nadja AU - Haiden N AUID- ORCID: 0000-0003-4806-0312 AD - Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. FAU - Fewtrell, Mary AU - Fewtrell M AUID- ORCID: 0000-0001-9783-3444 AD - UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Segerstad, Elin Hard Af AU - Segerstad EHA AUID- ORCID: 0000-0002-7676-1186 AD - Pediatric Research Instittute, Oslo University Hospital, Oslo, Norway. AD - Department of Pediatrics, Skane University Hospital, Malmoe, Sweden. FAU - Hojsak, Iva AU - Hojsak I AUID- ORCID: 0000-0003-3262-5964 AD - Children's Hospital Zagreb, University of Zagreb Medical School, Zagreb, Croatia. FAU - Norsa, Lorenzo AU - Norsa L AUID- ORCID: 0000-0003-3322-2921 AD - Pediatric Department, Vittore Buzzi Children's Hospital, Milan. AD - Department of Biomedical and Clinical Science, University of Milan, Milan, Italy. FAU - Koletzko, Berthold AU - Koletzko B AUID- ORCID: 0000-0002-5345-7165 AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Ludwig Maximilians Universitat Munich, Munich, Germany. AD - German Center for Child and Adolescent Health, site, Munich, Germany. LA - eng GR - None/ PT - Journal Article DEP - 20260630 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - 0 (cereulide) RN - 0 (Depsipeptides) SB - IM MH - Humans MH - *Food Contamination/analysis MH - *Infant Formula/chemistry/standards MH - *Depsipeptides/analysis/toxicity MH - Infant MH - *Food Safety MH - Risk Assessment MH - Europe MH - Bacillus cereus MH - Food Microbiology PMC - PMC13539648 OTO - NOTNLM OT - Bacillus cereus OT - infant formula OT - toxine COIS- Outside of submitted work: Nadja Haiden received honoraria, speakers fee, congress fee and/or participated in advisory boards of Baxter, Nutricia/Danone, Nestle, Hipp, Mead Johnson and Chiesi. Mary Fewtrel: None. Elin Hard af Segerstad received speakers fee from Fresenius Kabi, Dr Schar Sweden, and Semper Nutrition. Iva Hojsak received honoraria and speakers fee from Sandoz, Takeda, BioGaia, Hipp, Nutricia, Biocodex, Abbvie, Nestle and GM Pharma. Lorenzo Norsa: Received honoraria, speaker and congress fees and participated to advisory board for Nestle, Danone, Fresenius, Pfizer, Takeda, Sanofi, Vivsol, Zealand. Berthold Koletzko: LMU university hospital and its employee Berthold Koletzko benefitted from financial support for research and educational activities from Budenheim, Danone, DGC, Hipp, Nestle, Pfizer and reckitt. Berthold Koletzko is the Else Kroner Senior Professor of Paediatrics at LMU - University of Munich, financially supported by the charitable Else Kroner Fresenius Foundation, LMU Medical Faculty and LMU University Hospitals. EDAT- 2026/06/30 06:31 MHDA- 2026/09/03 17:36 PMCR- 2026/09/03 CRDT- 2026/06/30 04:03 PHST- 2026/03/18 00:00 [revised] PHST- 2026/03/18 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/09/03 17:36 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 04:03 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - JPN370488 [pii] AID - 10.1002/jpn3.70488 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Sep;83(3):371-373. doi: 10.1002/jpn3.70488. Epub 2026 Jun 30. PMID- 42374581 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260917 IS - 0778-7367 (Print) IS - 2049-3258 (Electronic) IS - 0778-7367 (Linking) VI - 84 IP - 1 DP - 2026 Jun 29 TI - International study of 24-hour movement behaviours among preschool children (SUNRISE): A pilot study from Nepal. LID - 10.1186/s13690-026-01984-2 [doi] LID - 204 AB - BACKGROUND: This study aimed to determine the proportion of Nepali preschool children (3-4 years of age) meeting the World Health Organization (WHO) 24- hour movement guidelines for physical activity (PA), sedentary behaviour and sleep by sex (male vs. female) and place of residence (urban vs. rural) and evaluate their executive functions and motor skills. Furthermore, it evaluated the feasibility and acceptability of methods proposed for the main SUNRISE study in diverse settings. METHODS: In this pilot study, a total of 99 preschool children, balancing sex and place of residence, each with one parent/caregiver, from Syangja District were recruited. Physical activity, sedentary behaviour and sleep were assessed using waist-worn ActiGraph accelerometers (ActiGraph wGT3x-BT) with >/= 1 valid 24-hour period of data, motor skills (gross and fine) were evaluated using the NIH Toolbox motor battery, and executive functions were assessed using the Early Years Toolbox. Eight focus group discussions (FGDs) were carried out with parents/caregivers, and a short interview was conducted with eight Early Childhood Development (ECD) centre teachers to explore the feasibility and acceptability of implementing the SUNRISE protocol. RESULTS: Only 10% of children met all components of the WHO 24-hour movement guidelines (>/= 180 min total PA, of which >/= 60 min were MVPA, /= 1 valid 24-hour period of data. Males and rural children accumulated more daily moderate-to-vigorous and vigorous physical activity than females and urban children, respectively. In contrast, females were more likely to meet screen time guidelines than males (66% vs. 42%, p = 0.018). Additionally, females had better inhibition control than males, and rural children had better working memory than urban children. Parent/caregivers and ECD teachers reported that the study procedures, including accelerometer use, were acceptable and feasible. CONCLUSIONS: Adherence to the full set of WHO movement guidelines was very low among preschool children in this study, with screen time emerging as the most challenging component. Targeted strategies are needed to promote healthier movement behaviours, particularly to reduce screen time. The findings support the feasibility and acceptability of conducting the main SUNRISE study in Nepal. CI - (c) 2026. The Author(s). FAU - Subedi, Narayan AU - Subedi N AD - Nepal Development Society, Kathmandu, Nepal. n.subedi@nedsnepal.org.np. AD - Nexus Institute of Research and Innovation, Kathmandu, Nepal. n.subedi@nedsnepal.org.np. FAU - Okely, Anthony D AU - Okely AD AD - School of Social Sciences, University of Wollongong, Wollongong, NSW, Australia. FAU - Bhandari, Buna AU - Bhandari B AD - Dwyer School of Health Sciences, Division of Health Sciences, Indiana University South Bend, South Bend, USA. FAU - Paudel, Susan AU - Paudel S AD - Nepal Development Society, Kathmandu, Nepal. AD - Centre for Adolescent Health, Department of Paediatrics, Melbourne Medical School, The University of Melbourne, Melbourne, Australia. LA - eng PT - Journal Article DEP - 20260629 PL - England TA - Arch Public Health JT - Archives of public health = Archives belges de sante publique JID - 9208826 PMC - PMC13576209 OTO - NOTNLM OT - 24-hour movement behaviour OT - Nepal OT - Physical activity OT - Preschool children OT - SUNRISE OT - Screen time OT - Urban and rural COIS- Declarations. Ethics approval and consent to participate: The SUNRISE pilot study received ethics approval from the Nepal Health Research Council (Registration number 225/2023). Written approval was obtained from the respective municipalities. All study participants (parents/caregivers) signed the informed consent form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/29 CRDT- 2026/06/30 00:07 PHST- 2025/11/28 00:00 [received] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 00:07 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 10.1186/s13690-026-01984-2 [pii] AID - 1984 [pii] AID - 10.1186/s13690-026-01984-2 [doi] PST - epublish SO - Arch Public Health. 2026 Jun 29;84(1):204. doi: 10.1186/s13690-026-01984-2. PMID- 42372278 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1539-3704 (Electronic) IS - 0003-4819 (Linking) VI - 179 IP - 9 DP - 2026 Sep TI - Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. PG - 1328-1337 LID - 10.7326/ANNALS-25-05468 [doi] AB - Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transformed obesity and diabetes management, with rapidly expanding indications and use among U.S. adults. Despite their promise, key questions remain about optimal treatment pathways, long-term safety, effectiveness across diverse populations, adherence, and economic impact. Real-world evidence (RWE) derived from electronic health records, claims, and other data sources could address these gaps, but unique challenges complicate its use, such as inconsistent insurance coverage, high discontinuation rates, medication shortages, compounded formulations, and off-label prescribing. To explore these issues, the National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop in May 2025 with experts from regulatory agencies, guideline committees, payers, and academia. Discussions focused on identifying knowledge gaps in GLP-1RA use, evaluating how RWE informs practice, assessing limitations of real-world data, and strategies to reduce bias in RWE. Presentations emphasized RWE's potential to complement randomized trials by capturing rare adverse events, long-term outcomes, and effectiveness in routine care. However, persistent challenges include data reliability, confounding, and incomplete capture of medication use and outcomes, particularly in pediatric and underserved populations. Coverage decisions remain heterogeneous across Medicare, Medicaid, and private payers and across time, underscoring the need for rigorous cost-benefit analyses. The workshop concluded that robust RWE is essential for developing value-based coverage policies and optimizing GLP-1RA use. Continued investment in high-quality data infrastructure and analytic methods will be critical to inform regulatory, clinical, and economic decisions as utilization expands. FAU - Arterburn, David AU - Arterburn D AD - Kaiser Permanente Washington Health Research Institute, Seattle, Washington (D.A.). FAU - Curtis, Lesley H AU - Curtis LH AUID- ORCID: 0000-0002-3286-9371 AD - Duke University School of Medicine, Durham, North Carolina (L.H.C., D.D., A.S.). FAU - Toh, Sengwee AU - Toh S AUID- ORCID: 0000-0002-5160-0810 AD - Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts (S.T., D.R.W.). FAU - Bradley, Marie C AU - Bradley MC AD - U.S. Food and Drug Administration, Washington, DC (M.C.B.). FAU - D'Alessio, David AU - D'Alessio D AD - Duke University School of Medicine, Durham, North Carolina (L.H.C., D.D., A.S.). FAU - Duchovny, Noelia AU - Duchovny N AUID- ORCID: 0009-0004-5626-0589 AD - Congressional Budget Office, Washington, DC (N.D.). FAU - Hines, David AU - Hines D AUID- ORCID: 0009-0000-8288-0029 AD - Metro Nashville Public Schools, Nashville, Tennessee (D.H.). FAU - Narain, Kimberly AU - Narain K AUID- ORCID: 0000-0001-8548-1728 AD - University of California, Los Angeles, Los Angeles, California (K.N.). FAU - Parekh, Anand AU - Parekh A AD - University of Michigan School of Public Health, Ann Arbor, Michigan (A.P.). FAU - Skinner, Asheley AU - Skinner A AD - Duke University School of Medicine, Durham, North Carolina (L.H.C., D.D., A.S.). FAU - Wee, Christina C AU - Wee CC AD - Annals of Internal Medicine and American College of Physicians, Philadelphia, Pennsylvania (C.C.W.). FAU - Wong, John B AU - Wong JB AUID- ORCID: 0000-0003-4203-9010 AD - Tufts University School of Medicine, Boston, Massachusetts (J.B.W.). FAU - Wright, Davene R AU - Wright DR AUID- ORCID: 0000-0002-8574-4572 AD - Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts (S.T., D.R.W.). FAU - Osganian, Stavroula K AU - Osganian SK AD - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland (S.K.O., C.H.). FAU - Hales, Craig AU - Hales C AUID- ORCID: 0000-0002-2355-1177 AD - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland (S.K.O., C.H.). LA - eng GR - K08 AG068372/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20260630 PL - United States TA - Ann Intern Med JT - Annals of internal medicine JID - 0372351 RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Hypoglycemic Agents) SB - IM MH - Humans MH - United States MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - *Hypoglycemic Agents/therapeutic use/economics/adverse effects MH - *Diabetes Mellitus, Type 2/drug therapy MH - *Insurance Coverage MH - National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) COIS- Disclosures: Disclosure forms are available with the article online. EDAT- 2026/06/29 22:36 MHDA- 2026/09/15 05:06 CRDT- 2026/06/29 17:03 PHST- 2026/09/15 05:06 [medline] PHST- 2026/06/29 22:36 [pubmed] PHST- 2026/06/29 17:03 [entrez] AID - 10.7326/ANNALS-25-05468 [doi] PST - ppublish SO - Ann Intern Med. 2026 Sep;179(9):1328-1337. doi: 10.7326/ANNALS-25-05468. Epub 2026 Jun 30. PMID- 42372031 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1360-0451 (Electronic) IS - 0954-0121 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Self-reported physical activity and associated health factors among individuals attending an urban HIV and sexual health clinic in the UK: a secondary analysis of a clinic-based cross-sectional survey. PG - 2137-2146 LID - 10.1080/09540121.2026.2686237 [doi] AB - Low levels of physical activity are associated with negative health consequences such as metabolic syndrome and depression, particularly among people living with HIV. Contemporary data on physical activity levels among people living with HIV in the United Kingdom are limited. In a cross-sectional survey, 280 respondents' (217 (78%) individuals living with and 62 (22%) without HIV) physical activity was assessed using the validated General Practice Physical Activity Questionnaire (GPPAQ). Socio-demographic characteristics and health factors were collected. A third of the respondents (33.21%) reported being physically active. Living with HIV (OR 0.35 (95%CI 0.19-0.62)), older age (OR 0.97 (95%CI 0.95-0.99)), Black ethnic background (OR 0.33 (95%CI 0.09-1.17)) and smoking (OR 0.55 (95%CI 0.27-1.11)) were associated with lower odds of being physically active in the univariate analyses. Risky alcohol consumption (OR 1.72 (95%CI 0.98-3.08)) and irregular dietary habits (OR 2.09 (95%CI 1.19-3.68)) were associated with being physically active. In the fully adjusted model, only the association between physical activity and HIVstatus persisted. Participants living with HIV were 59% less likely to report being physically active (adjusted OR 0.41, 95% CI 0.21-0.79). The low proportion of reported physical activity suggests a potential role for screening and guidance for exercise among HIV and sexual health clinic attendees. FAU - Bascombe, Florence AU - Bascombe F AUID- ORCID: 0000-0003-1005-6190 AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Mcalpine, Connor AU - Mcalpine C AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Milinkovic, Ana AU - Milinkovic A AD - Chelsea & Westminster Hospital NHS Foundation Trust, London, United Kingdom. FAU - Paredes, Jose Luis AU - Paredes JL AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Matthews, Rebecca AU - Matthews R AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Arenas-Pinto, Alejandro AU - Arenas-Pinto A AUID- ORCID: 0000-0002-3368-5005 AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. AD - MRC Clinical Trials Unit at UCL, London, United Kingdom. FAU - Suonpera, Emmi AU - Suonpera E AUID- ORCID: 0000-0001-9412-2516 AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. LA - eng PT - Journal Article DEP - 20260629 PL - England TA - AIDS Care JT - AIDS care JID - 8915313 SB - IM MH - Cross-Sectional Studies MH - *Exercise MH - United Kingdom MH - Self Report MH - Ambulatory Care Facilities/statistics & numerical data MH - *HIV Infections MH - *HIV Long-Term Survivors/statistics & numerical data MH - Surveys and Questionnaires MH - Health Behavior MH - Sexual Health MH - *Urban Health Services/statistics & numerical data MH - Socioeconomic Factors MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged OTO - NOTNLM OT - Cross-sectional OT - HIV OT - Physical activity OT - men who have sex with men OT - mental health EDAT- 2026/06/29 18:43 MHDA- 2026/10/07 17:33 CRDT- 2026/06/29 14:03 PHST- 2026/10/07 17:33 [medline] PHST- 2026/06/29 18:43 [pubmed] PHST- 2026/06/29 14:03 [entrez] AID - 10.1080/09540121.2026.2686237 [doi] PST - ppublish SO - AIDS Care. 2026 Oct;38(10):2137-2146. doi: 10.1080/09540121.2026.2686237. Epub 2026 Jun 29. PMID- 42371992 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1520-5118 (Electronic) IS - 0021-8561 (Linking) VI - 74 IP - 27 DP - 2026 Jul 15 TI - Unlocking the Potential of Lysophosphatidylcholine-Docosahexaenoic Acid in the Food Industry: From Biological Functions and Preparation to Safety Approvals and Market Prospects. PG - 20793-20818 LID - 10.1021/acs.jafc.5c17743 [doi] AB - Docosahexaenoic acid (DHA, C22:6, n-3) deficiency is associated with impaired neurodevelopment and neurodegenerative disorders, yet conventional DHA supplements show limited efficiency in brain targeting. Lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA) has attracted increasing interest because it aligns with MFSD2A-mediated transport and may improve DHA targeting to the brain. This review systematically summarizes sn-1/sn-2 LPC-DHA from a food and health perspective, covering its physicochemical features, biological rationale, preparation strategies, analytical characterization, safety concerns, regulatory progress, and application prospects. Particular emphasis is placed on synthesis of sn-1 LPC-DHA via enzymatic regioselective esterification of glycerophosphocholine (GPC), together with key constraints on yield and purity, including substrate solubility, water activity, oxidation, and acyl migration. We further highlight the need for standardized orthogonal analysis for reliable structural assignment. Current evidence supports the promise of LPC-DHA in maternal-infant nutrition, neurodegenerative intervention, and visual health, but stronger safety evaluation and clearer regulatory frameworks are still required. FAU - Wei, Teng AU - Wei T AD - College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi 330000, China. FAU - Wang, Yuan AU - Wang Y AD - College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi 330000, China. FAU - Zhang, Lei AU - Zhang L AD - State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi 330047, China. FAU - Wang, Xueqi AU - Wang X AD - State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi 330047, China. FAU - Xu, Yingzhi AU - Xu Y AD - College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi 330000, China. FAU - Wu, Na AU - Wu N AD - College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi 330000, China. FAU - Zhao, Yan AU - Zhao Y AD - College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi 330000, China. FAU - Li, Jing AU - Li J AUID- ORCID: 0000-0002-2271-7761 AD - State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi 330047, China. FAU - Tu, Yonggang AU - Tu Y AUID- ORCID: 0000-0003-3603-1565 AD - College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi 330000, China. LA - eng PT - Journal Article PT - Review DEP - 20260629 PL - United States TA - J Agric Food Chem JT - Journal of agricultural and food chemistry JID - 0374755 RN - 25167-62-8 (Docosahexaenoic Acids) RN - 0 (Lysophosphatidylcholines) SB - IM MH - *Docosahexaenoic Acids/chemistry/metabolism MH - Humans MH - *Lysophosphatidylcholines/chemistry/metabolism MH - Animals MH - Dietary Supplements/analysis MH - Food Industry MH - Brain/metabolism/drug effects OTO - NOTNLM OT - LPC-DHA OT - brain targeting OT - food industry OT - new DHA supplements OT - synthesis EDAT- 2026/06/29 18:43 MHDA- 2026/07/15 12:37 CRDT- 2026/06/29 13:53 PHST- 2026/07/15 12:37 [medline] PHST- 2026/06/29 18:43 [pubmed] PHST- 2026/06/29 13:53 [entrez] AID - 10.1021/acs.jafc.5c17743 [doi] PST - ppublish SO - J Agric Food Chem. 2026 Jul 15;74(27):20793-20818. doi: 10.1021/acs.jafc.5c17743. Epub 2026 Jun 29. PMID- 42371442 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - Maternal Knowledge, Attitudes, and Practices Regarding Complementary Feeding Among Children Under 2 Years of Age: An Urban-Rural Comparison in Jharkhand, India. PG - e109844 LID - 10.7759/cureus.109844 [doi] LID - e109844 AB - Background Appropriate complementary feeding during the period of 6-24 months is essential for meeting the growing nutritional requirements of infants that cannot be met by breast milk alone after six months of age. Maternal knowledge, attitudes, and practices (KAP) are critical determinants of infant feeding behavior. Urban-rural disparities in education, socioeconomic status, and healthcare access may contribute to differences in these practices. This study aimed to assess and compare maternal KAP regarding complementary feeding in urban and rural areas of Ranchi district, Jharkhand, using a validated scoring framework. Methods A community-based cross-sectional study was conducted among 305 mothers of children aged 6-24 months in urban Doranda (n=107) and rural Ormanjhi (n=198), the field practice areas of the Department of Community Medicine, RIMS, Ranchi. Data were collected using a pre-tested semi-structured questionnaire. KAP was assessed using a Bloom's cut-off-based scoring system: knowledge scores were classified as good (>/=80%), moderate (60-79%), or poor (<60%); attitude as positive, neutral, or negative; and practice as good, moderate, or poor. Associations were tested using the chi-square test, and ORs were calculated to describe KAP pathways. Statistical significance was set at p<0.05. Results Overall, 63.3% of mothers had good knowledge, 58.0% held positive attitudes, and 54.1% demonstrated good complementary feeding practices. Urban mothers performed significantly better across all three domains (p=0.032, p=0.041, and p=0.006, respectively). Good knowledge was strongly associated with positive attitude (OR=5.35; 95% CI: 3.23-8.86; p<0.001) and good practice (OR=4.47; 95% CI: 2.60-7.68; p<0.001). Positive attitude showed the strongest association with good complementary feeding practices (OR=5.27; 95% CI: 3.05-9.11; p<0.001). Maternal education and household income were the most significant sociodemographic determinants of KAP (p<0.001 for both). Conclusion While general awareness was relatively high, significant gaps existed in practices, particularly in rural areas. The study demonstrates a sequential pathway from knowledge to attitude to practice, with socioeconomic factors as the primary underlying determinants. Targeted nutrition education and behavior change communication through frontline health workers are essential to translate knowledge into improved complementary feeding practices. CI - Copyright (c) 2026, Kiran et al. FAU - Kiran, Kumari Asha AU - Kiran KA AD - Preventive Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Priya, Neha AU - Priya N AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Sunderam, Shalini AU - Sunderam S AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Anit, Anuj K AU - Anit AK AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Kumar, Dewesh AU - Kumar D AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Kujur, Anit AU - Kujur A AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. LA - eng PT - Journal Article DEP - 20260528 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13310283 OTO - NOTNLM OT - behaviour change communication OT - bloom's classification OT - child nutrition OT - complementary feeding OT - jharkhand OT - kap pathway OT - maternal kap OT - urban-rural comparison COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, Rajendra institute of Medical Sciences, Ranchi issued approval 312. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/06/29 12:32 MHDA- 2026/06/29 12:33 PMCR- 2026/05/28 CRDT- 2026/06/29 11:30 PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:32 [pubmed] PHST- 2026/06/29 11:30 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.7759/cureus.109844 [doi] PST - epublish SO - Cureus. 2026 May 28;18(5):e109844. doi: 10.7759/cureus.109844. eCollection 2026 May. PMID- 42371394 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260813 IS - 1573-6628 (Electronic) IS - 1092-7875 (Print) IS - 1092-7875 (Linking) VI - 30 IP - 7 DP - 2026 Jul TI - Multiple Output Gaussian Process Model for Predicting Low Birth Weight in Medellin, Colombia: An Alternative to Conventional Machine Learning Models. PG - 875-883 LID - 10.1007/s10995-026-04284-x [doi] AB - OBJECTIVE: To evaluate the methodological feasibility of a heterogeneous multi-output Gaussian process model for jointly handling a continuous birth outcome and its clinically used binary representation in routinely collected perinatal data, and to compare its predictive performance with that of conventional single-output models. METHODS: Routinely collected live-birth certificate data from Medellin, Colombia, covering births from 2012 to 2021, were analyzed. After cleaning and class balancing, the analytic dataset included 32,110 records. A heterogeneous multi-output Gaussian process model was trained to jointly model birth weight in grams with a Gaussian likelihood and low birth weight status with a Bernoulli likelihood. Predictive performance was compared with that of conventional single-output regression and classification models. RESULTS: The heterogeneous multi-output Gaussian process model achieved acceptable predictive performance (R(2) = 0.67 for birth weight and accuracy = 0.845 for low birth weight classification), with results comparable to those of models fitted separately for each task. These findings support the practical feasibility of modeling heterogeneous outputs within a single probabilistic framework. CONCLUSIONS: In this application, the heterogeneous multi-output Gaussian process model was a viable methodological alternative for jointly modeling birth weight in grams and its binary low-birth-weight classification. This study should be interpreted primarily as a methodological demonstration of a flexible multi-output framework in perinatal data that may be extended in future studies to jointly model other outcomes of greater direct relevance to public health. CI - (c) 2026. The Author(s). FAU - Salazar Blandon, Diego Alejandro AU - Salazar Blandon DA AUID- ORCID: 0000-0002-8724-7705 AD - School of Nursing, University of Antioquia, Medellin, Colombia. alejandro.salazar@udea.edu.co. FAU - Garcia Arias, Hernan Felipe AU - Garcia Arias HF AUID- ORCID: 0000-0002-2814-8838 AD - SISTEMIC research group, University of Antioquia, Medellin, Colombia. FAU - Giraldo Gutierrez, Juan Jose AU - Giraldo Gutierrez JJ AUID- ORCID: 0000-0002-9395-4289 AD - National Heart and Lung Institute, Imperial College London, London, UK. LA - eng PT - Journal Article DEP - 20260629 PL - United States TA - Matern Child Health J JT - Maternal and child health journal JID - 9715672 SB - IM MH - Humans MH - Colombia/epidemiology MH - *Infant, Low Birth Weight MH - *Machine Learning MH - Infant, Newborn MH - Predictive Learning Models MH - Normal Distribution MH - Female MH - Prediction Algorithms MH - Classification Algorithms MH - Birth Weight MH - Pregnancy MH - Birth Certificates MH - Models, Statistical PMC - PMC13451375 OTO - NOTNLM OT - Low birth weight OT - Machine learning OT - Models COIS- Declarations. Competing Interests: The authors declare that they have no competing interests. EDAT- 2026/06/29 12:33 MHDA- 2026/08/08 23:08 PMCR- 2026/06/29 CRDT- 2026/06/29 11:29 PHST- 2024/09/10 00:00 [received] PHST- 2026/05/16 00:00 [accepted] PHST- 2026/08/08 23:08 [medline] PHST- 2026/06/29 12:33 [pubmed] PHST- 2026/06/29 11:29 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 10.1007/s10995-026-04284-x [pii] AID - 4284 [pii] AID - 10.1007/s10995-026-04284-x [doi] PST - ppublish SO - Matern Child Health J. 2026 Jul;30(7):875-883. doi: 10.1007/s10995-026-04284-x. Epub 2026 Jun 29. PMID- 42370796 OWN - NLM STAT- Publisher LR - 20260629 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Jun 29 TI - Food insecurity, nutrition, and mental health in children after earthquake exposure: Evidence from Turkiye. PG - 2601060261464033 LID - 10.1177/02601060261464033 [doi] AB - BackgroundChildren are particularly vulnerable to the psychological and nutritional consequences of natural disasters such as earthquakes. Understanding the relationship between mental health outcomes and food insecurity is essential for effective post-disaster interventions.ObjectivesThis study aimed to assess the prevalence of post-traumatic stress disorder (PTSD), anxiety, and depressive symptoms among children exposed to the 2023 earthquake in Turkiye, and to examine their nutritional status and household food security.MethodsA multicenter, cross-sectional survey was conducted between March and August 2025 among 782 children aged 6-17 years from twelve earthquake-affected provinces. Participants were recruited using stratified cluster sampling from schools and community health centers. Psychological outcomes were assessed using validated instruments (CPSS, SCARED, CDI). Nutritional status was evaluated using anthropometric measurements, dietary diversity indicators, and standardized food security scales.ResultsOverall, 21.7% of participants met the CPSS cut-off for probable PTSD, with a higher prevalence among girls. Anxiety symptoms were identified in 25.8% and depressive symptoms in 21.4% of children. Nutritional assessment showed that 11.3% were underweight and 18.6% were overweight or obese. Additionally, 40.3% of households experienced food insecurity.ConclusionMental health problems and nutritional vulnerability frequently co-occur among children after earthquake exposure. Integrated interventions addressing both psychological well-being and food security are essential to support recovery in disaster-affected populations. FAU - Arslan, Nurgul AU - Arslan N AUID- ORCID: 0000-0002-7618-0859 AD - Department of Nutrition and Dietetics, Ataturk Faculty of Health Sciences, Dicle University, Diyarbakir, Turkiye. RINGGOLD: 37507 LA - eng PT - Journal Article DEP - 20260629 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Earthquakes OT - anxiety OT - children OT - depression OT - food security OT - mental health OT - nutritional status EDAT- 2026/06/29 12:33 MHDA- 2026/06/29 12:33 CRDT- 2026/06/29 09:43 PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:33 [pubmed] PHST- 2026/06/29 09:43 [entrez] AID - 10.1177/02601060261464033 [doi] PST - aheadofprint SO - Nutr Health. 2026 Jun 29:2601060261464033. doi: 10.1177/02601060261464033. PMID- 42370479 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260813 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 39 IP - 4 DP - 2026 Aug TI - Exploring Eating Patterns and Cooking Habits Among Emerging Adult College Students to Inform a Pilot Meal Kit Program. PG - e70299 LID - 10.1111/jhn.70299 [doi] LID - e70299 AB - INTRODUCTION: Emerging adult college students often experience poor diet quality (DQ) and rely heavily on ultra-processed foods (UPFs), such as sugary beverages, salty snacks, sweet snacks, and other calorie-dense, convenience foods. Meal kits, which provide pre-portioned ingredients and simple recipes, may offer a practical strategy to support healthier eating among emerging adults, yet their relevance and feasibility in college settings remain poorly understood. This study aims to assess the health behaviors, needs, and preferences of the target college student population to inform the development and feasibility of a pilot meal kit program. METHODS: This exploratory, community-informed research used a multi-method approach implemented in two phases: (1) an electronic survey of undergraduate students assessing sociodemographics, eating patterns, and meal preparation habits, and (2) virtual focus groups exploring protein intake, cooking behaviors, and desired meal-kit features. Quantitative data were analyzed using descriptive statistics, Pearson correlations, and logistic regression models. Qualitative data were coded using inductive thematic analysis. RESULTS: Students (N = 501) demonstrated low DQ (sHEI = 47.7 +/- 10.0/100), and 33.7% reported low or very low food security. Higher UPF intake (OR = 1.14, 95% CI [1.02, 1.25], p = 0.015), more frequent cooking (OR = 1.31, 95% CI [1.02, 1.70], p = 0.037), and greater food insecurity (OR = 1.08, 95% CI [1.003, 1.16], p = 0.042) significantly predicted interest in meal kits, although effect sizes were small (Nagelkerke R(2) = 0.015-0.023). Qualitative findings identified key barriers to healthy meal preparation, including limited time, inadequate kitchen access and equipment, financial constraints, and dissatisfaction with campus dining protein options. Students perceived meal kits as convenient and customizable but expressed concerns about affordability. CONCLUSION: Emerging adult college students face numerous barriers to healthy eating. Many view meal kits as a practical way to access convenient, nutritious meals. Affordable, culturally and economically tailored programs may help improve DQ and reduce reliance on UPFs. Findings support pilot testing a campus-based meal-kit program. CI - (c) 2026 The British Dietetic Association Ltd. FAU - Watras, Emma AU - Watras E AUID- ORCID: 0009-0003-4161-0024 AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. FAU - Mena, Noereem Z AU - Mena NZ AUID- ORCID: 0000-0002-7799-5566 AD - College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire, USA. FAU - Strout, Kelley AU - Strout K AUID- ORCID: 0000-0002-2575-1041 AD - School of Nursing, University of Maine, Orono, Maine, USA. FAU - Gayer, Kayla AU - Gayer K AUID- ORCID: 0000-0002-9038-0152 AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. FAU - Yerxa, Kathryn AU - Yerxa K AUID- ORCID: 0000-0001-9510-6358 AD - Cooperative Extension, University of Maine, Orono, Maine, USA. FAU - McNamara, Jade AU - McNamara J AUID- ORCID: 0000-0003-3242-330X AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. LA - eng GR - National Pork Board/ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Female MH - *Cooking/methods MH - *Students/psychology/statistics & numerical data MH - *Feeding Behavior/psychology MH - Young Adult MH - Universities MH - Pilot Projects MH - Male MH - *Meals/psychology MH - Adult MH - Food, Processed MH - *Diet, Healthy/psychology MH - Adolescent MH - Health Behavior MH - Food Preferences/psychology MH - Focus Groups MH - Fast Foods MH - Surveys and Questionnaires PMC - PMC13454157 OTO - NOTNLM OT - college students OT - cooking behaviors OT - diet quality OT - emerging adults OT - food insecurity OT - meal kits OT - ultra-processed foods COIS- The authors declare no conflicts of interest. EDAT- 2026/06/29 12:33 MHDA- 2026/06/29 12:34 PMCR- 2026/08/10 CRDT- 2026/06/29 07:23 PHST- 2026/05/27 00:00 [revised] PHST- 2026/02/19 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/29 12:34 [medline] PHST- 2026/06/29 12:33 [pubmed] PHST- 2026/06/29 07:23 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - JHN70299 [pii] AID - 10.1111/jhn.70299 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Aug;39(4):e70299. doi: 10.1111/jhn.70299. PMID- 42370376 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Childhood anemia and household salt iodization in Peru: population disparities among children aged 6-59 months. PG - 1865961 LID - 10.3389/fnut.2026.1865961 [doi] LID - 1865961 AB - BACKGROUND: Childhood anemia remains a priority public health problem in Peru. Although universal salt iodization is an established strategy to prevent iodine deficiency disorders, evidence on household-level salt iodization and disparities in anemia remains limited. OBJECTIVE: To estimate anemia prevalence and evaluate disparities according to the adequacy of iodine content in household salt among girls and boys aged 6 to 59 months in Peru, as well as to explore variation according to area of residence and household wealth level. METHODS: Analytical cross-sectional study using data from the Peruvian Demographic and Family Health Survey (ENDES) 2014-2023. We included 110,561 children aged 6 to 59 months with valid hemoglobin measurement and a household salt iodine rapid test. Anemia was defined as altitude-adjusted hemoglobin <11.0 g/dL. The main exposure was inadequate household salt iodization (<15 ppm), compared with adequate iodization (>/=15 ppm). Weighted prevalences, absolute gaps, and crude and adjusted prevalence ratios (PRs) were estimated using Poisson regression for complex survey design, adjusting for age and sex. RESULTS: The average weighted prevalence of anemia was 31.1% (95% CI: 30.7-31.6). Anemia was more frequent in households with inadequately iodized salt than in those with adequately iodized salt (35.73% vs. 30.49%). The absolute gap was 5.24 percentage points (95% CI: 3.7-6.7), and the crude PR was 1.17 (95% CI: 1.13-1.21). After adjustment for age and sex, the association remained (aPR = 1.16; 95% CI: 1.12-1.20). Absolute differences varied by area of residence and wealth quintile; no statistical evidence of additive-scale interaction was observed with extreme poverty or rural residence. Including 2024 as a sensitivity analysis did not materially change the estimate. CONCLUSION: Anemia was more frequent among children living in households with inadequately iodized salt. The findings support an interpretation centered on population disparities and nutritional vulnerability rather than on a direct causal relationship attributable to iodine in household salt. CI - Copyright (c) 2026 Briceno-Chavez, Portal-Valqui, Yoplac-Oyarce, Bustamante-Rodriguez, Ballena-Caicedo, Zuzunaga-Montoya and Vera-Ponce. FAU - Briceno-Chavez, Jhofree Einstein AU - Briceno-Chavez JE AD - Facultad de Medicina (FAMED), Universidad Nacional Toribio Rodriguez de Mendoza de Amazonas (UNTRM), Chachapoyas, Peru. FAU - Portal-Valqui, Lily Mabel AU - Portal-Valqui LM AD - Facultad de Medicina (FAMED), Universidad Nacional Toribio Rodriguez de Mendoza de Amazonas (UNTRM), Chachapoyas, Peru. FAU - Yoplac-Oyarce, Adriana Mishell AU - Yoplac-Oyarce AM AD - Facultad de Medicina (FAMED), Universidad Nacional Toribio Rodriguez de Mendoza de Amazonas (UNTRM), Chachapoyas, Peru. FAU - Bustamante-Rodriguez, Juan Carlos AU - Bustamante-Rodriguez JC AD - Facultad de Medicina (FAMED), Universidad Nacional Toribio Rodriguez de Mendoza de Amazonas (UNTRM), Chachapoyas, Peru. FAU - Ballena-Caicedo, Jhosmer AU - Ballena-Caicedo J AD - Facultad de Medicina (FAMED), Universidad Nacional Toribio Rodriguez de Mendoza de Amazonas (UNTRM), Chachapoyas, Peru. FAU - Zuzunaga-Montoya, Fiorella E AU - Zuzunaga-Montoya FE AD - Facultad de Medicina (FAMED), Universidad Nacional Toribio Rodriguez de Mendoza de Amazonas (UNTRM), Chachapoyas, Peru. FAU - Vera-Ponce, Victor Juan AU - Vera-Ponce VJ AD - Facultad de Medicina (FAMED), Universidad Nacional Toribio Rodriguez de Mendoza de Amazonas (UNTRM), Chachapoyas, Peru. LA - eng PT - Journal Article DEP - 20260612 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13307304 OTO - NOTNLM OT - Peru OT - anemia OT - child nutrition OT - health disparities OT - iodine OT - iodized salt COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/29 13:10 MHDA- 2026/06/29 13:11 PMCR- 2026/06/12 CRDT- 2026/06/29 07:05 PHST- 2026/04/26 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/29 13:11 [medline] PHST- 2026/06/29 13:10 [pubmed] PHST- 2026/06/29 07:05 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.3389/fnut.2026.1865961 [doi] PST - epublish SO - Front Nutr. 2026 Jun 12;13:1865961. doi: 10.3389/fnut.2026.1865961. eCollection 2026. PMID- 42370059 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 2753-4294 (Electronic) IS - 2753-4294 (Linking) VI - 4 IP - 2 DP - 2026 TI - Identifying developmental vulnerability through linear growth screening: a UK cross-sectional study. PG - e004567 LID - 10.1136/bmjph-2025-004567 [doi] LID - e004567 AB - INTRODUCTION: Linear growth in early childhood is routinely measured in the UK, but it is unclear whether indicators of linear growth faltering can flag children with neurodevelopmental vulnerability, especially in ethnically diverse urban settings. We tested whether short stature (stunting) or being short for genetic potential identifies children at risk of failing routine developmental screening at age 2-2.5 years. METHODS: We conducted a cross-sectional analysis among 555 children aged 24-30 months (mean 26.0 months, SD 1.5) attending Healthy Child Programme reviews in East London. The sample was ethnically diverse, with substantial proportions of Bangladeshi, White and other minority ethnic groups. Developmental vulnerability was defined as scoring below the Ages and Stages Questionnaire, Third Edition (ASQ-3) cut-off in >/=1 domain. The exposures were stunting (height-for-age z score <-2 SD) and being short for genetic potential, defined as deviation from mid-parental height (DMPH) <-2 SD. Associations were examined using binomial multivariable logistic regression adjusted for age, sex, prematurity, maternal education, ethnicity and household benefits. A subset (n=94) completed the Griffiths III Mental Development Scales (GMDS-III) to validate ASQ-3 classification. RESULTS: Overall, 141/555 (25.4%) children screened positive for developmental vulnerability on the ASQ-3. Children with developmental vulnerability had significantly lower GMDS-III scaled scores across multiple domains supporting criterion validity. We did not find evidence of an association between stunting and developmental vulnerability (adjusted OR 1.35, 95% CI 0.47 to 3.49). In contrast, children who were short for genetic potential (DMPH <-2 SD) had higher odds of developmental vulnerability (adjusted OR 4.18, 95% CI 1.13 to 14.78). CONCLUSIONS: In this urban UK cohort, deviation from genetic height potential, rather than stunting, identified children at increased risk of developmental vulnerability. Incorporating parental heights into routine growth surveillance could offer a simple trigger for earlier neurodevelopmental review. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Papasavva, Michael AU - Papasavva M AUID- ORCID: 0000-0003-2111-9783 AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Orr, Joanna AU - Orr J AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Cordani, Isabella AU - Cordani I AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Oloko, Lola AU - Oloko L AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Hutchinson, Celes AU - Hutchinson C AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Norton, Christopher AU - Norton C AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Kamaljit, Kaur AU - Kamaljit K AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Freer, Joseph AU - Freer J AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Walton, Robert AU - Walton R AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Storr, Helen L AU - Storr HL AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Smuk, Melanie AU - Smuk M AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Prendergast, Andrew J AU - Prendergast AJ AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13295896 OTO - NOTNLM OT - Humans OT - Public Health OT - Sociodemographic Factors COIS- None declared. EDAT- 2026/06/29 16:10 MHDA- 2026/06/29 16:11 PMCR- 2026/06/23 CRDT- 2026/06/29 07:03 PHST- 2025/11/19 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/29 16:11 [medline] PHST- 2026/06/29 16:10 [pubmed] PHST- 2026/06/29 07:03 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - bmjph-2025-004567 [pii] AID - 10.1136/bmjph-2025-004567 [doi] PST - epublish SO - BMJ Public Health. 2026 Jun 23;4(2):e004567. doi: 10.1136/bmjph-2025-004567. eCollection 2026. PMID- 42369452 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260923 IS - 2667-0097 (Electronic) IS - 2667-0097 (Linking) VI - 16 DP - 2026 Jun TI - Higher-volume breastmilk to improve growth among preterm infants in Zambia: A randomized clinical trial. LID - 100343 [pii] LID - 10.1016/j.gpeds.2026.100343 [doi] AB - OBJECTIVE: To test the hypothesis that among very preterm infants, higher-volume feeding versus usual-volume feeding with exclusive breastmilk improves growth at 40-weeks' postmenstrual age (PMA). DESIGN/METHODS: We conducted a randomized controlled trial among preterm infants 28 0/7 to 31 6/7 weeks' gestation or weighing 1000-1999 g at birth admitted to the Kangaroo Mother Care Ward at the Women and Newborn Hospital, Lusaka, Zambia between June 2022 and February 2023. Study participants were randomized with a 1:1 parallel allocation to usual-volume breastmilk (140-180 ml/kg/day) or higher-volume breastmilk (200-240 ml/kg/day) achieved with additional breastmilk expression. Daily measurements of feeding volume were recorded until discharge. Following hospital discharge, study participants were assessed at 40-weeks' postmenstrual age for weight, length, mid-arm circumference, and head circumference. The primary outcome was growth velocity from enrolment to 40-weeks' postmenstrual age. RESULTS: 190 preterm infants were enrolled. The mean+/-standard deviation (SD) number of days from enrollment to discharge was 9 +/- 4 days. Recorded breastmilk volumes during hospitalization differed between groups (239 +/-47 mL/kg/day in higher-volume versus 189+/-84 mL/kg/day in usual-volume; p < 0.001). There was no difference in growth velocity to 40 weeks' PMA between groups (mean+/-SD, higher-volume 14.1 +/- 4.8 g/kg/day versus usual-volume 14.6 +/- 5.4 g/kg/day; p = 0.51). The mid-arm circumference increased in the higher-volume group (10.9 +/- 1.3 cm versus 10.5 +/- 1.1 cm; p = 0.04) but other growth parameters did not differ at 40-weeks' postmenstrual age. Adverse outcomes did not differ. CONCLUSIONS: Higher-volume exclusive breastmilk feeding with breastmilk expression is feasible but did not improve growth velocity at 40-weeks' postmenstrual age in very preterm infants. FAU - Travers, Colm P AU - Travers CP AUID- ORCID: 0000-0002-3218-1024 AD - Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - Salas, Ariel A AU - Salas AA AD - Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - Jeffcoat, Seabrook AU - Jeffcoat S AD - Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - Lakhwani, Jyoti AU - Lakhwani J AD - Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. AD - Women and Newborn Hospital, University Teaching Hospitals, Lusaka, Zambia. FAU - Kapesa, Herbert AU - Kapesa H AD - Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. FAU - Nalwamba, Leukanji AU - Nalwamba L AD - Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. FAU - Carlo, Waldemar A AU - Carlo WA AD - Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - Manasyan, Albert AU - Manasyan A AD - Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, United States. AD - Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. LA - eng GR - K23 HD102554/HD/NICHD NIH HHS/United States GR - K23 HL157618/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260512 PL - United States TA - Glob Pediatr JT - Global pediatrics JID - 9918590689006676 PMC - PMC13298055 MID - NIHMS2187176 OTO - NOTNLM OT - Breast feeding OT - Enteral feeding OT - Growth and development OT - Infant low birth weight OT - Infant newborn OT - Infant nutrition disorders OT - Infant premature OT - Postnatal growth COIS- Conflicts of interest statement Potential Conflicts of Interest: The authors have no conflicts of interest relevant to this article to disclose. EDAT- 2026/06/29 16:10 MHDA- 2026/06/29 16:11 PMCR- 2026/06/26 CRDT- 2026/06/29 06:58 PHST- 2026/06/29 16:11 [medline] PHST- 2026/06/29 16:10 [pubmed] PHST- 2026/06/29 06:58 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 100343 [pii] AID - 10.1016/j.gpeds.2026.100343 [doi] PST - ppublish SO - Glob Pediatr. 2026 Jun;16:100343. doi: 10.1016/j.gpeds.2026.100343. Epub 2026 May 12. PMID- 42369321 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Association between achievement motivation and anxiety symptoms among college students. PG - 1868871 LID - 10.3389/fpsyg.2026.1868871 [doi] LID - 1868871 AB - BACKGROUND: Emotional problems are prevalent among college students, and many experience low levels of achievement motivation. This study investigated the correlation between achievement motivation and anxiety symptoms among medical students from Jining Medical University in Jining, China. METHOD: In September 2025, a cross-sectional study was performed among 3,173 college students in Jining City. Data were collected through electronic questionnaires consisting of three core components: sociodemographic characteristics, the Achievement Motivation Scale, and the 7-item Generalized anxiety symptoms Scale (GAD-7). Statistical analyses were conducted using SPSS 27.0 software, including univariate analysis, multiple logistic regression analysis and correlation analysis, to identify factors associated with anxiety symptoms and achievement motivation, as well as to verify the correlation between these two variables. RESULTS: A total of 3,173 questionnaires were distributed, and 2,827 valid questionnaires were collected, with an effective response rate of 89.09%; among the 2,827 college students surveyed, 28.76% reported mild anxiety symptoms, 4.89% reported moderate symptoms, and 1.31% reported severe symptoms. Achievement motivation analysis revealed that 59.43% of the participants exhibited high levels, while 35.58% showed low levels. Multivariate logistic regression analysis revealed that the severity of anxiety was significantly associated with being left behind in childhood, family income, parental health status, chronic diseases (respiratory/digestive systems), satisfaction with major, and academic planning (p < 0.05), but not with age, height, weight, gender, or BMI. The severe anxiety group exhibited more pronounced health risk behaviors and academic adaptation issues, necessitating targeted interventions. Related research has shown that anxiety severity was significantly positively correlated with failure avoidance motivation, and negatively correlated with success pursuit motivation. CONCLUSION: Our study reveals that anxiety symptoms are significantly associated with individual patterns of achievement motivation. Achievement motivation is closely correlated with anxiety symptoms among college students: fear of failure is linked to higher anxiety levels, while pursuit of success is related to lower anxiety levels. These findings suggest that motivational orientation adjustments may be an important target in mental health interventions, though causal direction remains to be established. To promote college students' mental health, schools should carry out adaptive motivation training programs to help students shift from a "failure-avoidance" motivational orientation toward a "success-pursuit" orientation. Meanwhile, targeted academic planning guidance should be integrated into mental health intervention, as academic planning showed a protective role against severe anxiety in the current study. While simultaneously strengthening psychological support and academic planning guidance for students with backgrounds such as left-behind experiences or family financial difficulties. CI - Copyright (c) 2026 Liu, Wang, Bai, Zhang, Li, Li, Dong, Zhang, Xu and Sun. FAU - Liu, Jiayu AU - Liu J AD - Clinical Medical College, Jining Medical University, Jining, Shandong, China. FAU - Wang, Chunting AU - Wang C AD - Fengtai District Center for Disease Control and Prevention, Beijing, China. FAU - Bai, Haoge AU - Bai H AD - Clinical Medical College, Jining Medical University, Jining, Shandong, China. FAU - Zhang, Hongwei AU - Zhang H AD - School of Educational Science, Jiangsu Normal University, Xuzhou, Jiangsu, China. FAU - Li, Jiale AU - Li J AD - College of Medical Imaging and Laboratory, Jining Medical University, Jining, Shandong, China. FAU - Li, Yixuan AU - Li Y AD - College of Medical Imaging and Laboratory, Jining Medical University, Jining, Shandong, China. FAU - Dong, Xin AU - Dong X AD - College of Mental Health, Jining Medical University, Jining, Shandong, China. FAU - Zhang, Xuanhe AU - Zhang X AD - Clinical Medical College (Affiliated Hospital), Jining Medical University, Jining, Shandong, China. FAU - Xu, Fangfang AU - Xu F AD - School of Mental Health (Research Institute of Mental Health), Jining Medical University, Jining, Shandong, China. FAU - Sun, Hao AU - Sun H AD - Clinical Medical College, Jining Medical University, Jining, Shandong, China. LA - eng PT - Journal Article DEP - 20260611 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13293948 OTO - NOTNLM OT - achievement motivation OT - anxiety symptoms OT - college students OT - educational psychology OT - emotional disorders COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/29 12:32 MHDA- 2026/06/29 12:33 PMCR- 2026/06/11 CRDT- 2026/06/29 06:56 PHST- 2026/04/29 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:32 [pubmed] PHST- 2026/06/29 06:56 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1868871 [doi] PST - epublish SO - Front Psychol. 2026 Jun 11;17:1868871. doi: 10.3389/fpsyg.2026.1868871. eCollection 2026. PMID- 42369304 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Mood changes of children and adolescents in dance classes: a prospective repeated-measures study. PG - 1719704 LID - 10.3389/fpsyg.2026.1719704 [doi] LID - 1719704 AB - INTRODUCTION: Adolescent mental health in the United States has deteriorated markedly over the past decade, with diagnosed mental or behavioral health conditions among 12-to-17-year-olds increasing 35% between 2016 and 2023, driven by a 61% rise in anxiety diagnoses and a 45% rise in depression. Community-based interventions combining physical activity, creative expression, and social connection represent a promising response. METHODS: This prospective repeated-measures study examined the association between structured dance education and mood among 256 children and adolescents (ages 5-17) at four studio locations. Over 4 months (February-May 2025), students completed 4,224 paired pre- and post-class mood ratings using a single-item emoji scale; the primary analytic sample comprised 4,059 sessions from 251 students. PANAS-C administrations provided a concurrent measure of dispositional affect, with each student's score anchored to the administration nearest the study close. Multilevel models accounted for the nested data structure (students contributing 1-109 sessions each). RESULTS: The intraclass correlation was 0.432. Post-class mood was significantly higher than pre-class mood (session-level Cohen's d = 0.27 [primary estimate] and per-student d_z = 0.43 [p < 0.001]) with 85.8% of sessions showing maintained or improved mood. A Tobit sensitivity analysis confirmed these patterns after adjusting for the 28.8% post-class ceiling rate. No covariate (including weekly frequency, class type, proficiency level, or instructor experience) explained significant additional variance. Individual differences dominated: random slopes improved model fit substantially (DeltaAIC = 201). Convergent validity between the emoji scale and PANAS-C Positive Affect was significant (r = 0.19, p = 0.011, n = 175), with the strongest association among students attending 4-6 classes per week (r = 0.51, n = 25). CONCLUSION: Dance participation was associated with a consistent acute mood benefit generalizing across genres, schedules, and experience levels; individual characteristics, rather than program features, accounted for most meaningful variation. The observational design precludes causal attribution. CI - Copyright (c) 2026 Henderson, Henderson, Robertson-Kraft and Levick. FAU - Henderson, Tiffany C AU - Henderson TC AD - Master of Applied Positive Psychology Program, University of Pennsylvania, Philadelphia, PA, United States. AD - Tiffany's Dance Academy, Livermore, CA, United States. FAU - Henderson, Paul R AU - Henderson PR AD - Raising the Barre, Livermore, CA, United States. FAU - Robertson-Kraft, Claire AU - Robertson-Kraft C AD - Master of Applied Positive Psychology Program, University of Pennsylvania, Philadelphia, PA, United States. FAU - Levick, Judy Saltzberg AU - Levick JS AD - Master of Applied Positive Psychology Program, University of Pennsylvania, Philadelphia, PA, United States. LA - eng PT - Journal Article DEP - 20260611 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13293843 OTO - NOTNLM OT - PANAS-C OT - children and adolescents OT - dance education OT - ecological momentary assessment OT - mood OT - multilevel modeling OT - positive psychology OT - well-being COIS- TH and PH are co-founders of Tiffany's Dance Academy, a for-profit dance studio business, and Raising the Barre, a 501(c)(3) youth-service nonprofit organization, both based in Livermore, CA, USA. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/29 12:32 MHDA- 2026/06/29 12:33 PMCR- 2026/06/11 CRDT- 2026/06/29 06:56 PHST- 2025/10/06 00:00 [received] PHST- 2026/04/14 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:32 [pubmed] PHST- 2026/06/29 06:56 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1719704 [doi] PST - epublish SO - Front Psychol. 2026 Jun 11;17:1719704. doi: 10.3389/fpsyg.2026.1719704. eCollection 2026. PMID- 42368948 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Formal uniforms as an environmental constraint on NEAT and adolescent obesity: a cross-sectional study in boarding schools. PG - 1817702 LID - 10.3389/fpubh.2026.1817702 [doi] LID - 1817702 AB - BACKGROUND: The rising prevalence of obesity in adolescents is commonly attributed to a decrease in moderate to vigorous physical activity (MVPA), but the role of environmental constraints on thermogenesis from non-exercise activities (NEAT) remains under-explored. School uniforms are a daily necessity and may be associated with physical or perceived barriers to spontaneous low-intensity movement. This study investigated the relationship between type of school uniform (formal versus athletic) and body mass index (BMI) and examined whether NEAT-related behaviors showed a statistical mediation pattern in a gender-specific manner. METHOD: A cross-sectional study was conducted in four 100 percent boarding secondary schools in China. A total of 1,068 adolescents were stratified by mandatory uniform type. NEAT-related behaviors were assessed using an adapted self-reported questionnaire and compared with accelerometry-derived metrics in a sedentary validation sub-sample (n = 108). Mediation analyses and moderated mediation analyses were conducted to examine the uniform type, NEAT-related behaviors, and BMI associations. RESULTS: Formal uniforms were significantly associated with higher BMI in women (Delta = 0.7 kg/m(2), p < 0.01) but not in men (p > 0.05). Mediation analyses suggested that this association was statistically mediated by lower NEAT-related behaviors [beta_indirect = 0.123, 95% CI (0.054, 0.208)], accounting for 60.3% of the total effect. Exploratory subgroup analyses showed a larger uniform-BMI difference among students in the lowest NEAT-related activity decile: in the lowest decile of sedentary behavior, the difference in body mass index between homogeneous groups widened from a negligible amount in highly active girls to a larger observed difference of 1.3 kg/m(2) (p < 0.01). CONCLUSION: Formal school uniforms were associated with lower NEAT-related movement and higher body mass index in adolescent females in this study population. This relationship was more pronounced among students with lower baseline activity levels, suggesting that restrictive clothing may act as an environmental constraint on spontaneous low-intensity movement. These findings suggest that movement-friendly school uniform designs may warrant further investigation in residential school settings. CI - Copyright (c) 2026 Wang, Lin, Zhang and Liu. FAU - Wang, Yuan AU - Wang Y AD - School Uniform Management Professional Committee, China Association for Campus Management, Beijing, China. FAU - Lin, Rubing AU - Lin R AD - Department of Orthopedics, Shenzhen Children's Hospital, Shenzhen, China. FAU - Zhang, Wei AU - Zhang W AD - Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, China. FAU - Liu, Yantong AU - Liu Y AD - Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, China. AD - Department of Computer and Information Engineering, Kunsan National University, Gunsan, Republic of Korea. LA - eng PT - Journal Article DEP - 20260612 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Adolescent MH - Body Mass Index MH - China/epidemiology MH - *Schools MH - *Pediatric Obesity/epidemiology MH - *Clothing/statistics & numerical data MH - *Thermogenesis/physiology MH - *Exercise/physiology MH - Accelerometry PMC - PMC13303609 OTO - NOTNLM OT - adolescent obesity OT - environmental constraint OT - gender disparity OT - non-exercise activity thermogenesis (NEAT) OT - school uniforms OT - sedentary behavior COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/29 16:10 MHDA- 2026/06/29 16:11 PMCR- 2026/06/12 CRDT- 2026/06/29 06:52 PHST- 2026/02/25 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/29 16:11 [medline] PHST- 2026/06/29 16:10 [pubmed] PHST- 2026/06/29 06:52 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1817702 [doi] PST - epublish SO - Front Public Health. 2026 Jun 12;14:1817702. doi: 10.3389/fpubh.2026.1817702. eCollection 2026. PMID- 42368298 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260926 IS - 1687-8728 (Print) IS - 1687-8736 (Electronic) IS - 1687-8728 (Linking) VI - 2026 DP - 2026 TI - Morphological Study of the Characteristics of Lips in Children With Mouth Breathing. PG - 1585193 LID - 10.1155/ijod/1585193 [doi] LID - 1585193 AB - OBJECTIVE: This study aimed to explore the association between long-term mouth breathing habits and the morphological characteristics of children's lips, providing a basis for clinical diagnosis and early intervention. Given the cross-sectional design and reliance on parental questionnaire-based exposure classification, causal inference is not warranted; findings are strictly associative. METHODS: A total of 210 children aged 6-12 years were enrolled, comprising 105 children clinically classified as long-term mouth-breathing children and 105 nasal-breathing children. Classification was based on a validated parental questionnaire with defined major and minor signs; objective airway assessment was not performed, which is acknowledged as a limitation. Lip morphological characteristics were analyzed from standardized lateral cephalograms. Quantitative parameters included protrusion of the subnasal region, upper lip, lower lip, and chin; length of the upper lip, lower lip, and chin; the ratio of upper lip length to lower lip length; nasolabial angle; mentolabial angle. Comparisons between groups used independent-samples t-tests with covariate adjustment (analysis of covariance [ANCOVA]) for age, sex, and BMI, and the Benjamini-Hochberg false discovery rate (FDR) correction for multiple comparisons. Effect sizes (Cohen's d) and 95% confidence intervals (CIs) are reported. RESULTS: Significant positive correlations were found among Ns to N' Vert, UL to N' Vert, LL to N' Vert, Pog' to N' Vert, UL-L, LL-L, and Cn-L. Compared with nasal-breathing children, mouth-breathing children showed decreased protrusion of the subnasal region and upper lip, retraction of the chin, a sharper nasolabial angle, and a more obtuse mentolabial angle. No significant difference in lower lip protrusion (LL to N' Vert) was found between groups (adjusted p = 0.225). Because all participants were recruited from an orthodontic clinic, these findings may not be generalizable to the general pediatric population. CONCLUSIONS: Mouth breathing is associated with significant differences in lip and facial soft-tissue morphology in children, particularly in the protrusion and length of the subnasal region, upper lip, and chin, as well as in nasolabial and mentolabial angles. Early identification and interdisciplinary management of mouth breathing may be important for preventing further morphological changes; however, longitudinal studies are needed to establish temporal relationships and causal mechanisms. CI - Copyright (c) 2026 Lu Wenting et al. International Journal of Dentistry published by John Wiley & Sons Ltd. FAU - Wenting, Lu AU - Wenting L AUID- ORCID: 0009-0000-3613-0550 AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Xiaowei, Wu AU - Xiaowei W AUID- ORCID: 0009-0000-7248-839X AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Shengdan, Yu AU - Shengdan Y AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Xin, Yan AU - Xin Y AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Mengyuan, Guo AU - Mengyuan G AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Lili, Hou AU - Lili H AUID- ORCID: 0000-0001-6489-1744 AD - Department of Nursing, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China, shsmu.edu.cn. FAU - Xiaogang, Pan AU - Xiaogang P AUID- ORCID: 0000-0001-8623-4526 AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Int J Dent JT - International journal of dentistry JID - 101524183 EIN - Int J Dent. 2026 Aug 11;2026:9769151. doi: 10.1155/ijod/9769151. PMID: 42591848 PMC - PMC13306110 OTO - NOTNLM OT - children OT - early intervention OT - lip morphological characteristics OT - mouth breathing COIS- The authors declare no conflicts of interest. EDAT- 2026/06/29 12:32 MHDA- 2026/06/29 12:33 PMCR- 2026/06/26 CRDT- 2026/06/29 06:46 PHST- 2025/05/20 00:00 [received] PHST- 2026/04/28 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:32 [pubmed] PHST- 2026/06/29 06:46 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - IJOD1585193 [pii] AID - 10.1155/ijod/1585193 [doi] PST - epublish SO - Int J Dent. 2026 Jun 26;2026:1585193. doi: 10.1155/ijod/1585193. eCollection 2026. PMID- 42366751 OWN - NLM STAT- Publisher LR - 20260629 IS - 1469-672X (Electronic) IS - 0264-6838 (Linking) DP - 2026 Jun 28 TI - Interpersonal psychotherapy for adolescent gestational weight gain and wellbeing: pilot and feasibility randomised controlled trial. PG - 1-17 LID - 10.1080/02646838.2026.2694056 [doi] AB - AIMS/BACKGROUND: Pregnant adolescents face adversities that heighten perinatal complications in mental (e.g. depression) and physical (e.g. excess gestational weight gain [GWG]) health. Depression may affect excess GWG through stress-related behaviours. We sought to pilot feasibility/acceptability of integrating a brief mental health intervention within prenatal care to address depression and stress-related behaviours contributing to excess GWG. DESIGN/METHODS: The current study reports recruitment/retention, feasibility, and intervention/protocol acceptability of a pilot randomised controlled trial with N = 37 pregnant 13-19-year-olds receiving multidisciplinary prenatal care (NCT03086161). Participants were randomised to 6 x 1-hour individual interpersonal psychotherapy sessions plus usual multidisciplinary prenatal care (IPT+UC) or usual care only (UC). Feasibility was tracked using CONSORT flow. Adolescents completed acceptability ratings at post-program. Within-condition and between-group changes in social functioning, depression, stress-related behaviours, and GWG were assessed from baseline to mid-programme and post-programme. RESULTS: 88% of potentially eligible patients enrolled. At mid-programme, 43% were retained in IPT+UC versus 38% in UC; at post-program 38% were retained in IPT+UC versus 35% in UC. Within IPT+UC, 47% received >/= 80% IPT dosage. Adolescents rated IPT acceptability above-average. Within-group, IPT+UC showed decreased mother-adolescent negative interactions at mid-programme (r = .76, p = .01) and post-programme (r = .63, p = .04). There was no difference in gestational weight gain between arms (epsilon(2) = .02, p = .87). CONCLUSION: Brief, integrated mental health therapy in multidisciplinary prenatal care for adolescents has feasible enrolment and may offer an acceptable approach for mental-physical health. Dosage and retention require refinement. Incorporating dissemination/implementation science principles is warranted in future tests of IPT to support the mental-physical health of pregnant adolescents. FAU - Joslin, Steffany AU - Joslin S AD - Department of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA. AD - Department of Pediatrics, Section of Endocrinology, University of Colorado Anschutz and Children's Hospital Colorado, Aurora, CO, USA. FAU - Gulley, Lauren D AU - Gulley LD AD - Department of Pediatrics, Section of Endocrinology, University of Colorado Anschutz and Children's Hospital Colorado, Aurora, CO, USA. FAU - Pyle, Laura AU - Pyle L AD - Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine, Seattle, WA, USA. FAU - Clark, Emma L M AU - Clark ELM AD - Department of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA. FAU - Tanofsky-Kraff, Marian AU - Tanofsky-Kraff M AD - Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, MD, USA. FAU - Nadeau, Kristen J AU - Nadeau KJ AD - Department of Pediatrics, Section of Endocrinology, University of Colorado Anschutz and Children's Hospital Colorado, Aurora, CO, USA. FAU - Barbour, Linda A AU - Barbour LA AD - Department of Medicine, University of Colorado Anschutz, Aurora, CO, USA. AD - Department of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO, USA. FAU - Scott, Stephen M AU - Scott SM AD - Department of Medicine, University of Colorado Anschutz, Aurora, CO, USA. AD - Department of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO, USA. FAU - Sheeder, Jeanelle L AU - Sheeder JL AD - Department of Medicine, University of Colorado Anschutz, Aurora, CO, USA. AD - Department of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO, USA. FAU - Shomaker, Lauren B AU - Shomaker LB AD - Department of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA. AD - Department of Pediatrics, Section of Endocrinology, University of Colorado Anschutz and Children's Hospital Colorado, Aurora, CO, USA. AD - Department of Community and Behavioral Health, Colorado School of Public Health, Aurora, CO, USA. LA - eng PT - Journal Article DEP - 20260628 PL - England TA - J Reprod Infant Psychol JT - Journal of reproductive and infant psychology JID - 8501885 SB - IM OTO - NOTNLM OT - Interpersonal psychotherapy OT - adolescence OT - depression OT - obesity, pregnancy EDAT- 2026/06/29 06:30 MHDA- 2026/06/29 06:30 CRDT- 2026/06/29 02:44 PHST- 2026/06/29 06:30 [medline] PHST- 2026/06/29 06:30 [pubmed] PHST- 2026/06/29 02:44 [entrez] AID - 10.1080/02646838.2026.2694056 [doi] PST - aheadofprint SO - J Reprod Infant Psychol. 2026 Jun 28:1-17. doi: 10.1080/02646838.2026.2694056. PMID- 42366551 OWN - NLM STAT- Publisher LR - 20260629 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) DP - 2026 Jun 28 TI - Group-based aquatic exercise for adolescents with down syndrome; a pilot study. PG - 1-11 LID - 10.1080/09638288.2026.2691633 [doi] AB - PURPOSE: Adolescents with Down syndrome (ADS) have reduced physical activity (PA) levels compared to peers. Aquatic exercise may appeal to ADS because the aquatic environment allows for increased ease of movement and mobility. However, research surrounding group-based aquatic exercise programs for ADS is limited. The purpose of the study was to investigate the safety, feasibility, and preliminary outcomes of group-based aquatic exercise for ADS. MATERIALS AND METHODS: Nine ADS, participated in a twice-weekly, one-hour group-based aquatic exercise class over eight weeks. Safety was assessed via heart rate monitoring and critical incidents. Feasibility was assessed through program adherence and parent perception of convenience. Outcome measures included the timed up-and-go test (TUG), five-repetition sit-to-stand test (FRSTST), six-minute walk test (6MWT), pediatric quality of life inventory (PedsQL TM), and a parent satisfaction survey. Scores were compared with pre- and post-intervention and at 4-week follow-up. RESULTS: There were no critical safety incidents. Program adherence was > 85%. Improvements in the 6MWT and the PedsQL TM were found (p < .017). Improvements exceeding the minimal detectable change were obtained for the 6MWT, TUG, FRSTST, and PedsQL TM. Parent satisfaction was high. CONCLUSION: Group-based aquatic exercise may provide a safe, feasible and effective alternative to PA in ADS. FAU - Conklin, Ashley B AU - Conklin AB AD - The Department of Rehabilitation and Movement Sciences at Rutgers, The State University of New Jersey. Rutgers University, Newark, NJ, USA. FAU - Martin, Kathy AU - Martin K AD - The Krannert School of Physical Therapy at The University of Indianapolis, The University of Indianapolis, Indianapolis, IN, USA. FAU - Ennis, Beth AU - Ennis B AD - Currently unaffiliated. FAU - Moore, Elizabeth AU - Moore E AD - The College of Health Sciences at The University of Indianapolis, The University of Indianapolis, Indianapolis, IN, USA. LA - eng PT - Journal Article DEP - 20260628 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM OAB - Adolescents with Down syndrome have reduced physical activity levels compared to their typically developing peers, placing them at higher risk of health-related complications and a sedentary lifestyle.A twice-weekly, 1-hour aquatic exercise program incorporating moderate intensity aerobic exercise and strength maneuvers was implemented with nine adolescents with Down syndrome over an 8 week period.The aquatic exercise program was safe, feasible and well received by all participants, with high levels of parent satisfaction reported.Despite the relatively small sample size, the preliminary results of this pilot study support the implementation of group-based aquatic exercise as a means of improving both social and physical health and well-being for adolescents with Down syndrome. OABL- eng OTO - NOTNLM OT - Down syndrome OT - adolescents OT - aquatic exercise OT - group exercise OT - physical activity EDAT- 2026/06/29 06:30 MHDA- 2026/06/29 06:30 CRDT- 2026/06/29 01:02 PHST- 2026/06/29 06:30 [medline] PHST- 2026/06/29 06:30 [pubmed] PHST- 2026/06/29 01:02 [entrez] AID - 10.1080/09638288.2026.2691633 [doi] PST - aheadofprint SO - Disabil Rehabil. 2026 Jun 28:1-11. doi: 10.1080/09638288.2026.2691633. PMID- 42366411 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 29 TI - A prospective longitudinal interventional cohort study on maternal nutrition and pregnancy outcomes in urban Cameroon (CAMELIA): study protocol. LID - 10.1186/s12884-026-09536-w [doi] LID - 1017 AB - BACKGROUND: Maternal nutritional exposures during pregnancy are critical determinants of maternal and neonatal outcomes, yet remain inadequately characterized in many African settings, including Cameroon. The CAMELIA (Cameroon Maternal and Early Life Assessment) cohort aims to evaluate maternal nutritional status early in pregnancy, implement a structured nutritional intervention, and assess its impact on maternal, neonatal, and long-term metabolic outcomes. METHODS: CAMELIA is a prospective, longitudinal interventional cohort enrolling 1,200 pregnant women at less than 22 weeks' gestation in an urban primary healthcare facility in Cameroon (Hopital Monseigneur Jean Zoa, Yaounde). Participants are recruited at the first antenatal visit and followed through delivery and up to 42 days postpartum. Data and biological samples are collected across four visits: at enrolment (< 22 weeks), between 24 and 32 weeks of gestation, at delivery, and at 42 days postpartum. A structured multi-modal nutritional intervention (SUN-APP program) is initiated at enrolment, delivered through individual counselling, group education, monthly interactive workshops, and digital health support via weekly WhatsApp and SMS messages. Gestational hyperglycaemia is screened using fasting capillary blood glucose at V1 and V2, applying a threshold of >/= 92 mg/dL. Primary outcomes are feasibility and acceptability of the intervention. Secondary outcomes include prevalence of gestational hyperglycaemia, hypertensive disorders, anaemia, low birth weight, and preterm birth. The study holds ethical approval from the Cameroon National Ethics Committee (CNERSH; approval no. 2025/04/1790/CE/CNERSH/SP) and is registered in the ISRCTN registry (ISRCTN13961105). CONCLUSIONS: The CAMELIA study provides a scalable and replicable framework for embedding structured nutritional risk screening and targeted interventions into routine antenatal care in a low-resource African setting. Findings will inform strategies for the prevention of gestational metabolic disorders and adverse perinatal outcomes across generations. TRIAL REGISTRATION: ISRCTN13961105. Registered 14 August 2025. CI - (c) 2026. The Author(s). FAU - Zemsi, Sylvain AU - Zemsi S AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Ekwoge, Diane AU - Ekwoge D AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Saha, Brice AU - Saha B AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Biochemistry, University of Bamenda, Bamenda, Cameroon. FAU - Kalla, Valdes AU - Kalla V AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Minkam, Azalee AU - Minkam A AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Ayeni, Doris AU - Ayeni D AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Tsanga, Michel AU - Tsanga M AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Ndi, Jean Arnaud AU - Ndi JA AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Powo, Arnold AU - Powo A AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Baban, Thierry AU - Baban T AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Toulouse National Polytechnique Institute, Toulouse, France. FAU - Guewo, Magellan AU - Guewo M AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Katte, Jean Claude AU - Katte JC AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - University of Exeter, Exeter, UK. FAU - Ondobo, Xavier AU - Ondobo X AD - Hopital Monseigneur Jean Zoa de Nkolndongo, Yaounde, Cameroon. FAU - Sobngwi-Tambekou, Joelle AU - Sobngwi-Tambekou J AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Fezeu, Leopold AU - Fezeu L AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Universite Sorbonne Paris Nord and Universite Paris Cite, INSERM, INRAE, CNAM, Centre for Research in Epidemiology and Statistics (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, F-93017, France. FAU - Sobngwi, Eugene AU - Sobngwi E AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. eugenesobngwi@gmail.com. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. eugenesobngwi@gmail.com. LA - eng PT - Journal Article DEP - 20260629 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Cameroon/epidemiology MH - Prospective Studies MH - *Pregnancy Outcome MH - Longitudinal Studies MH - Adult MH - *Maternal Nutritional Physiological Phenomena MH - Infant, Newborn MH - *Nutritional Status MH - *Prenatal Care/methods MH - *Pregnancy Complications/epidemiology MH - Premature Birth/epidemiology MH - Diabetes, Gestational/epidemiology MH - Urban Population PMC - PMC13576244 OTO - NOTNLM OT - Africa OT - Cameroon OT - Cohort study OT - Environmental exposure OT - Gestational diabetes OT - Hypertensive disorders OT - Maternal health OT - Neonatal outcomes OT - Nutrition OT - Pregnancy COIS- Declarations. Ethics approval and consent to participate: The CAMELIA study received ethical clearance from the National Ethics Committee for Research in Human Health (CNERSH) of Cameroon (approval no. 2025/04/1790/CE/CNERSH/SP). Written informed consent is obtained from all participants. For participants under 21 years of age, written parental consent and participant assent are required. All study procedures are conducted in accordance with Good Clinical Practice (ICH-GCP) and the Declaration of Helsinki. All information collected is kept strictly confidential. Participants are identified by a unique coded number; no names, addresses, or telephone numbers are disclosed to any researcher outside the core study team. Records and samples are securely archived for future research. Participants have explicitly consented to the storage of biological samples (blood and urine, including umbilical cord blood) in the RSD Institute biobank and to their use in future ethically approved research studies. The study protocol, information sheets, and consent forms have been submitted to the CNERSH for approval and remain subject to review for any substantial amendments. Any amendments will be communicated to the ISRCTN registry within 15 days. Competing interests: The authors declare no competing interests. EDAT- 2026/06/29 04:10 MHDA- 2026/09/15 05:36 PMCR- 2026/06/29 CRDT- 2026/06/28 23:25 PHST- 2026/05/21 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/15 05:36 [medline] PHST- 2026/06/29 04:10 [pubmed] PHST- 2026/06/28 23:25 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 10.1186/s12884-026-09536-w [pii] AID - 9536 [pii] AID - 10.1186/s12884-026-09536-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 29;26(1):1017. doi: 10.1186/s12884-026-09536-w. PMID- 42365683 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260824 IS - 1532-2122 (Electronic) IS - 1462-3889 (Linking) VI - 83 DP - 2026 Aug TI - Effect of an aerobic exercise-based programme throughout chemotherapy on cognitive function in patients with breast cancer: A non-randomized controlled study. PG - 103251 LID - S1462-3889(26)00156-0 [pii] LID - 10.1016/j.ejon.2026.103251 [doi] AB - PURPOSE: Chemotherapy-related cognitive impairment (CRCI) is a prevalent neurotoxicity in patients with breast cancer (BC), leading to cognitive decline and reduced quality of life. Exercise is recommended as a potential strategy to mitigate CRCI; however, optimal exercise modalities and protocols remain unclear. Moreover, implementing exercise during chemotherapy presents practical and adherence challenges, highlighting the need for feasible, targeted exercise interventions. This study aimed to evaluate the effects of an aerobic exercise programme delivered throughout chemotherapy on cognitive function in patients with BC. METHODS: A non-randomized controlled clinical trial was conducted in patients aged 18-65 years with stage I-III breast cancer undergoing chemotherapy. Participants received either usual care or an aerobic exercise-based programme delivered throughout chemotherapy, incorporating behavioural and social support components. Subjective and objective cognitive function, fatigue, quality of life, and physical fitness were assessed at baseline, mid-chemotherapy, and post-intervention. RESULTS: Fifty-nine patients (intervention group, n = 28 vs. control group, n = 31) were enrolled into the study, and 48 (24 per group) completed all tests at final-chemotherapy. Compared with the control group, significant improvements were observed in all measurements of cognitive function, fatigue, quality of life, and grip strength (healthy) after the intervention (p < .05). CONCLUSION: The aerobic exercise-based program had beneficial effects on cognitive function, fatigue, quality of life, and grip strength. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Liu, Yu AU - Liu Y AD - School of Nursing, Fujian Medical University, Fuzhou, 350122, PR China; School of Nursing, Capital Medical University, You An Men, Beijing, 100069, PR China. FAU - Su, Yali AU - Su Y AD - Department of Breast Oncology, Beijing Tiantan Hospital, Capital Medical University, South 4th Ring Road West, Beijing, 100050, PR China. FAU - Bai, Lixiao AU - Bai L AD - Department of Breast Cancer, The Fifth Medical Centre of Chinese People's Liberation Army (PLA) General Hospital, Beijing, PR China. FAU - Yang, Ailing AU - Yang A AD - Department of Breast Cancer, The Fifth Medical Centre of Chinese People's Liberation Army (PLA) General Hospital, Beijing, PR China. FAU - Zhao, Fuyun AU - Zhao F AD - School of Nursing, Capital Medical University, You An Men, Beijing, 100069, PR China. FAU - Liu, Jun-E AU - Liu JE AD - School of Nursing, Capital Medical University, You An Men, Beijing, 100069, PR China. Electronic address: liujune66@ccmu.edu.cn. FAU - Chen, Shaohua AU - Chen S AD - School of Nursing, Fujian Medical University, Fuzhou, 350122, PR China. Electronic address: chenshaohua0312@163.com. LA - eng PT - Controlled Clinical Trial PT - Journal Article DEP - 20260619 PL - Scotland TA - Eur J Oncol Nurs JT - European journal of oncology nursing : the official journal of European Oncology Nursing Society JID - 100885136 RN - 0 (Antineoplastic Agents) SB - IM MH - Humans MH - Female MH - *Breast Neoplasms/drug therapy/psychology MH - Middle Aged MH - Adult MH - Quality of Life MH - *Exercise Therapy/methods MH - Aged MH - *Cognition/physiology MH - *Antineoplastic Agents/adverse effects/therapeutic use MH - *Exercise/physiology MH - *Chemotherapy-Related Cognitive Impairment/prevention & control MH - Young Adult MH - Treatment Outcome MH - Adolescent MH - Physical Fitness OTO - NOTNLM OT - Behavior promotion OT - Breast cancer OT - Chemotherapy OT - Cognitive function OT - Exercise COIS- Declaration of competing interest The authors have no conflicts of interest to report. EDAT- 2026/06/28 18:31 MHDA- 2026/07/24 00:37 CRDT- 2026/06/28 18:00 PHST- 2026/03/03 00:00 [received] PHST- 2026/05/31 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/07/24 00:37 [medline] PHST- 2026/06/28 18:31 [pubmed] PHST- 2026/06/28 18:00 [entrez] AID - S1462-3889(26)00156-0 [pii] AID - 10.1016/j.ejon.2026.103251 [doi] PST - ppublish SO - Eur J Oncol Nurs. 2026 Aug;83:103251. doi: 10.1016/j.ejon.2026.103251. Epub 2026 Jun 19. PMID- 42365611 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260706 IS - 1471-2865 (Electronic) IS - 1358-2267 (Linking) VI - 31 IP - 3 DP - 2026 Jul TI - Reliability of Pressure Pain Threshold Measurements of Upper and Lower Limb Muscles of Young Swimmers: An Observational Study. PG - e70262 LID - 10.1002/pri.70262 [doi] AB - BACKGROUND AND PURPOSE: Objective measures should be combined with subjective assessments to monitor pain and discomfort, particularly in sports with a high prevalence of atraumatic injuries. Therefore, this study aimed to determine the reliability of pressure pain threshold (PPT) measurements in competitive swimmers and to explore the influence of intrinsic and extrinsic factors on PPT. METHODS: Forty-seven swimmers were included in the study. PPT was measured bilaterally in 10 muscles of the upper and lower limbs and trunk using a hand-held algometer. Two trained physiotherapists performed four consecutive evaluations on the same day, with a 5-min interval between repeated measures, in randomized order to minimize carryover effects. Intrinsic variables included age, body mass index, shoulder pain, injury history, and years of practice. Extrinsic variables included swimming style, swimming distance, competitive level, training frequency, and training duration. Reliability was assessed using intraclass correlation coefficients, standard error of measurement, minimal detectable change, and coefficient of variation. The influence of intrinsic and extrinsic factors on PPT was explored using multivariate analysis of variance. RESULTS: Reliability varied from good to excellent across all muscles, with ICC values between 0.75 and 0.95. Descriptive data indicated that swimmers competing at the national level had higher PPT values compared with regional/state athletes, and butterfly specialists showed slightly higher PPTs. Across all participants, lower limb muscles consistently exhibited higher PPT values than upper limb muscles (e.g., rectus femoris mean 4.2 kg/cm(2) vs. biceps brachii mean 2.8 kg/cm(2)). CONCLUSIONS: Reliability was high across all muscles, and PPT differences observed appear to reflect training level, stroke specialization, and muscle group characteristics rather than intrinsic or injury-related factors. Furthermore, applications up to 5 kgf are safe and well tolerated in the lower limb, which differs from the usual threshold of 2.55 kgf commonly used in the upper limb. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Carrion Caldeira Ribeiro, Gabriela AU - Carrion Caldeira Ribeiro G AUID- ORCID: 0000-0002-5952-7603 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Alves de Carvalho, Flavia AU - Alves de Carvalho F AUID- ORCID: 0000-0002-2740-4959 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Paes de Lima, Heloisa AU - Paes de Lima H AUID- ORCID: 0000-0002-1460-0141 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Moreira de Castro Pereira Perez Espinoza, Rafael AU - Moreira de Castro Pereira Perez Espinoza R AUID- ORCID: 0000-0002-8167-7448 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Machado da Silva, Isaque AU - Machado da Silva I AUID- ORCID: 0009-0002-8339-7287 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Zacharias de Souza, Ricardo AU - Zacharias de Souza R AUID- ORCID: 0009-0003-6411-017X AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Pastre, Carlos Marcelo AU - Pastre CM AUID- ORCID: 0000-0002-0213-6679 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article PT - Observational Study PL - United States TA - Physiother Res Int JT - Physiotherapy research international : the journal for researchers and clinicians in physical therapy JID - 9612022 SB - IM MH - Humans MH - *Swimming/physiology MH - Female MH - Reproducibility of Results MH - Male MH - *Pain Threshold/physiology MH - Adolescent MH - *Upper Extremity/physiology/physiopathology MH - *Pain Measurement/methods MH - *Lower Extremity/physiology MH - *Muscle, Skeletal/physiopathology MH - Pressure OTO - NOTNLM OT - muscle sensitivity OT - pressure algometry OT - swimmer EDAT- 2026/06/28 18:30 MHDA- 2026/06/28 18:31 CRDT- 2026/06/28 13:22 PHST- 2026/06/09 00:00 [revised] PHST- 2024/11/06 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/28 18:31 [medline] PHST- 2026/06/28 18:30 [pubmed] PHST- 2026/06/28 13:22 [entrez] AID - 10.1002/pri.70262 [doi] PST - ppublish SO - Physiother Res Int. 2026 Jul;31(3):e70262. doi: 10.1002/pri.70262. PMID- 42365345 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260917 IS - 1477-9560 (Print) IS - 1477-9560 (Electronic) IS - 1477-9560 (Linking) VI - 24 IP - 1 DP - 2026 Jun 27 TI - Association between D-dimer difference and risk of postoperative venous thromboembolism in endometrial cancer: a retrospective cohort study. LID - 10.1186/s12959-026-00893-2 [doi] LID - 84 AB - OBJECTIVE: To investigate the association between D-dimer level changes and venous thromboembolism (VTE) risk in endometrial cancer patients undergoing surgery. METHODS: This retrospective cohort study included 307 endometrial cancer patients who underwent surgical treatment at Fujian Maternity and Child Health Hospital between January 2022 and December 2024, with follow-up to December 2025. D-dimer change was the exposure variable and VTE occurrence the outcome. Multivariable logistic regression assessed independent effects after adjusting for 17 covariates, including age, body mass index, FIGO stage, and comorbidities. Threshold effect and stratified analyses were conducted. RESULTS: Each one-unit increase in D-dimer change was significantly associated with higher VTE risk (adjusted OR = 1.202; 95% CI: 1.076-1.342; P = 0.001). Nonlinear testing revealed a significant threshold effect (P < 0.001) at 3.78: below this threshold, VTE risk increased sharply (OR = 7.761; 95% CI: 4.286-14.051); above it, risk declined (OR = 0.643; 95% CI: 0.526-0.785). Mediation analysis showed anticoagulant therapy, infection, and caprinin had negligible mediating effects (proportion < 0.2%; P > 0.86). CONCLUSION: D-dimer level changes exhibit a nonlinear association with postoperative VTE risk, characterized by a distinct threshold effect. These hypothesis-generating findings suggest that monitoring D-dimer trajectories rather than absolute values may offer a novel dimension for perioperative VTE risk stratification, warranting prospective validation in multicenter cohorts before clinical application. CI - (c) 2026. The Author(s). FAU - Li, Weipeng AU - Li W AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zheng, Hui AU - Zheng H AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zhen, Lan AU - Zhen L AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Qiu, Qian AU - Qiu Q AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zhu, Leilei AU - Zhu L AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zhang, Rong AU - Zhang R AD - Department of Vascular Surgery & Interventional Therapy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Yi, Huan AU - Yi H AUID- ORCID: 0009-0009-9209-916X AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. yi.huan@fjmu.edu.cn. LA - eng GR - No.2025Y9627/the Joint Funds for the Innovation of Science and Technology,Fujian Province/ PT - Journal Article DEP - 20260627 PL - England TA - Thromb J JT - Thrombosis journal JID - 101170542 PMC - PMC13576260 OTO - NOTNLM OT - D-dimer OT - Endometrial cancer OT - Postoperative complications OT - Threshold effect OT - Venous thromboembolism COIS- Declarations. Ethical approval: This study was approved by the Ethics Committee of Fujian Provincial Maternal and Child Health Hospital and strictly adhered to the tenets of the Declaration of Helsinki (IRB: No. 2025KY115). Consent for publication: Not applicable. As this study was a retrospective analysis of de-identified data and the requirement for informed consent was waived by the institutional ethics committee, specific consent for publication was not required. Competing interests: The authors declare no competing interests. EDAT- 2026/06/28 04:09 MHDA- 2026/06/28 04:10 PMCR- 2026/06/27 CRDT- 2026/06/27 23:26 PHST- 2026/02/23 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/06/28 04:10 [medline] PHST- 2026/06/28 04:09 [pubmed] PHST- 2026/06/27 23:26 [entrez] PHST- 2026/06/27 00:00 [pmc-release] AID - 10.1186/s12959-026-00893-2 [pii] AID - 893 [pii] AID - 10.1186/s12959-026-00893-2 [doi] PST - epublish SO - Thromb J. 2026 Jun 27;24(1):84. doi: 10.1186/s12959-026-00893-2. PMID- 42365173 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261008 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 80 IP - 9 DP - 2026 Sep TI - Evaluation of a context-specific diet diversity score (DDS) for predicting micronutrient adequacy in 6-10-year-old rural Indian children. PG - 919-927 LID - 10.1038/s41430-026-01779-2 [doi] AB - BACKGROUND: Low diet diversity is the major contributor to micronutrient inadequacy among children, underscoring a need for a rapid assessment tool to assess micronutrient adequacy. OBJECTIVE: This study aimed to (i) develop a context-specific diet diversity score (DDS) tool (ii) evaluate the performance of the DDS scoring system against mean probability of adequacy for 10 micronutrients, 5 biomarkers of micronutrient status and (iii) identify an optimal DDS cut-off by applying minimum portion size threshold to support its potential use as a practical screening tool. METHODS: A cross-sectional study was conducted among 6-10-year-old children (n = 76) in two villages of Ghatkesar sub-district, Telangana. Portion sizes of commonly consumed fruits and vegetables were standardized. Data on household demographics, anthropometry, and biomarkers of micronutrient status were collected using a pretested questionnaire and standardized protocols. Three non-consecutive 24-hour-dietary-recalls were obtained using the weighment method. DDS was developed based on the nutrient content of consumed foods; minimum intake thresholds of 0.1 g, 5 g and 10 g was applied while scoring. Mean probability of adequacy (MPA) for 10 micronutrients was estimated using ICMR-EAR values. Correlations of DDS with MPA and biomarkers were examined, and sensitivity and specificity were assessed using ROC curves, considering MPA >/= 70% as adequate. RESULTS: The DDS included 13 food groups. Mean DDS (5 g threshold) was 8.67 +/- 1.50 and correlated significantly with MPA (r = 0.58), and hemoglobin (t = 2.07). A DDS-5 g cut-off of >/=10 predicted MPA > 70%, with an AUC of 0.89. CONCLUSION: The DDS showed good predictive performance for micronutrient adequacy, but requires further field validation before programmatic use. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Konapur, Archana AU - Konapur A AD - Nutrition Information Communication and Health Education (NICHE) Division, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. FAU - Krishnapillai, Madhavan Nair AU - Krishnapillai MN AD - Independent Researcher; Formerly, Micronutrient Research Group, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Director, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. FAU - Nagalla, Balakrishna AU - Nagalla B AUID- ORCID: 0000-0002-5613-0942 AD - Department of Statistics, Apollo Hospitals Educational & Research Foundation, Hyderabad, Telangana State, India. FAU - Gavaravarapu, SubbaRao M AU - Gavaravarapu SM AUID- ORCID: 0000-0003-4524-9646 AD - Nutrition Information Communication and Health Education (NICHE) Division, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. Subbarao.gm@icmr.gov.in. AD - Faculty of Medical Science, Academy for Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India. Subbarao.gm@icmr.gov.in. LA - eng GR - 5/9/1138/2014-NUT/Indian Council of Medical Research (ICMR)/ PT - Journal Article DEP - 20260627 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 RN - 0 (Micronutrients) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Micronutrients/administration & dosage/deficiency/blood MH - Child MH - Cross-Sectional Studies MH - India MH - Female MH - *Diet MH - Rural Population MH - *Nutrition Assessment MH - Male MH - Nutritional Status MH - Biomarkers/blood MH - Surveys and Questionnaires MH - Vegetables MH - Fruit MH - ROC Curve MH - Sensitivity and Specificity COIS- Competing interests: The authors declare no competing interests. Ethical approval: The study was approved by the Institutional Ethics Committee (IEC) of ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India (08/I/2014 & CR03/II/2016 (revised)); all methods were performed in accordance with the institutional guidelines and regulations. Written informed consent was obtained from all the participants before initiation of data collection. EDAT- 2026/06/28 00:38 MHDA- 2026/09/10 05:37 CRDT- 2026/06/27 23:19 PHST- 2025/10/23 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/05/25 00:00 [revised] PHST- 2026/09/10 05:37 [medline] PHST- 2026/06/28 00:38 [pubmed] PHST- 2026/06/27 23:19 [entrez] AID - 10.1038/s41430-026-01779-2 [pii] AID - 10.1038/s41430-026-01779-2 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Sep;80(9):919-927. doi: 10.1038/s41430-026-01779-2. Epub 2026 Jun 27. PMID- 42365169 OWN - NLM STAT- Publisher LR - 20260627 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 27 TI - Diet, lifestyle, metabolic markers, and socioeconomic status are associated with cognitive function in school-aged children from a population-based cohort. LID - 10.1038/s41390-026-05250-7 [doi] AB - BACKGROUND: Cognitive development is associated with diet, activity, sleep, metabolic health, and socioeconomic status. However, evidence remains limited, as most studies have focused on clinical groups or single factors. We examined the combined associations of these variables with cognitive function in school-aged children from the general population. METHODS: We evaluated 170 school-aged children from a population-based cohort (mean age 6.33 +/- 0.03 years; 49% female). Children were evaluated after an overnight fast (>8 h), and anthropometric, metabolic, and socioeconomic variables were evaluated. Diet and physical activity were assessed using validated questionnaires (Vioque FFQ and enKid). Cognitive function was assessed using NEPSY-II and TONI-2 subsets. Correlation and regression analyses were performed. RESULTS: Cognitive function was positively associated with Mediterranean diet adherence, sleep duration, socioeconomic status, and negatively associated with ultra-processed food intake, TV viewing, and metabolic markers including insulin resistance (HOMA-IR), C-reactive protein, and gamma-glutamyltransferase (all p < 0.05). Multivariate analyses showed that Mediterranean diet adherence (OR 2.18, 95%CI 1.08-4.40), economic status (OR 2.50, 95%CI 1.13-5.49), sleep duration (OR 2.90, 95%CI 1.42-5.92), and HOMA-IR (OR 0.47, 95%CI 0.23-0.96) as independently associated with cognitive outcomes, particularly in attention, language, and memory. CONCLUSIONS: Lifestyle factors and socioeconomic conditions are independently associated with cognitive function in children. IMPACT: Key message: Diet, sleep, metabolic health, and socioeconomic status are associated with cognitive function in school-aged children. Novelty: Simultaneously examines multiple factors associated with cognition in school-aged children from a population-based cohort. Impact on cognition: Mediterranean diet adherence, sleep duration, and metabolic health were positively associated with several cognitive domains, including attention, language, and memory. Practical use: Highlights the potential relevance of healthy lifestyles and social equity in relation to cognitive development. Broader significance: Highlights the multifactorial nature of cognitive development in children. CI - (c) 2026. The Author(s). FAU - Gomez-Vilarrubla, Ariadna AU - Gomez-Vilarrubla A AUID- ORCID: 0000-0001-8183-5218 AD - Maternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. FAU - Sanchez-Fernandez, Mario AU - Sanchez-Fernandez M AUID- ORCID: 0009-0009-7616-8559 AD - Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain. FAU - Puerto-Carranza, Elsa AU - Puerto-Carranza E AUID- ORCID: 0000-0003-3478-5072 AD - Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain. FAU - Martinez-Calcerrada, Jose-Maria AU - Martinez-Calcerrada JM AUID- ORCID: 0000-0002-4021-2513 AD - Maternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. FAU - Mas-Pares, Berta AU - Mas-Pares B AUID- ORCID: 0000-0001-8283-3089 AD - Pediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. FAU - Rivero-Martin, Maria-Jose AU - Rivero-Martin MJ AUID- ORCID: 0000-0003-2186-0475 AD - Department of Pediatrics, Hospital Universitario de Fuenlabrada, Madrid, Spain. FAU - Nso-Roca, Ana-Pilar AU - Nso-Roca AP AUID- ORCID: 0000-0002-0601-0213 AD - Department of Pediatrics, Hospital Universitario San Juan de Alicante, San Juan de Alicante, Spain. FAU - Alvarez-Monell, Adam AU - Alvarez-Monell A AUID- ORCID: 0000-0003-4806-3361 AD - Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universitat Autonoma de Barcelona (INc-UAB), Barcelona, Spain. FAU - Contreras-Rodriguez, Oren AU - Contreras-Rodriguez O AUID- ORCID: 0000-0001-8922-8084 AD - Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universitat Autonoma de Barcelona (INc-UAB), Barcelona, Spain. AD - CIBER Mental Health (CIBERSAM), Carlos III Health Institute, Madrid, Spain. FAU - Garre-Olmo, Josep AU - Garre-Olmo J AUID- ORCID: 0000-0002-7817-0814 AD - Department of Medical Sciences, University of Girona, Girona, Spain. FAU - Lopez-Bermejo, Abel AU - Lopez-Bermejo A AUID- ORCID: 0000-0002-5828-8911 AD - Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain. alopezbermejo@idibgi.org. AD - Pediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. alopezbermejo@idibgi.org. AD - Department of Medical Sciences, University of Girona, Girona, Spain. alopezbermejo@idibgi.org. FAU - Bassols, Judit AU - Bassols J AUID- ORCID: 0000-0001-8821-6655 AD - Maternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. jbassols@idibgi.org. LA - eng PT - Journal Article DEP - 20260627 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Patient consent: Written informed consent was obtained from the parents or legal guardians of all participating children prior to enrolment in the study. EDAT- 2026/06/28 00:37 MHDA- 2026/06/28 00:37 CRDT- 2026/06/27 23:19 PHST- 2025/10/28 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/05/28 00:00 [revised] PHST- 2026/06/28 00:37 [medline] PHST- 2026/06/28 00:37 [pubmed] PHST- 2026/06/27 23:19 [entrez] AID - 10.1038/s41390-026-05250-7 [pii] AID - 10.1038/s41390-026-05250-7 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 27. doi: 10.1038/s41390-026-05250-7. PMID- 42365081 OWN - NLM STAT- Publisher LR - 20260627 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jun 27 TI - Predicting children's undernutrition and its association with women's asset ownership in Ethiopia: spatial machine learning. LID - 10.1038/s41598-026-59905-w [doi] AB - Child undernutrition remains a critical public health concern, with prominent geographic and structural disparities in Ethiopia. Understanding how women's asset share and spatial context interact to affect nutritional risk is vital for effective interventions. This study investigates the spatial patterns of child undernutrition, its association with women's asset ownership and other covariates, and the predictive performance of spatial machine learning techniques in making predictions. Using the nationally representative ESPS 2021/22 for model development and internal validation through spatial cross-validation with a 70/30 split, alongside temporal validation employing ESPS I, 2018/19. The metrics were used to compare four machine learning algorithms (random forest, gradient-boosted trees, support vector machines, and geographical random forests) with spatial features to a spatial generalized linear mixed model. The semivariogram result showed a strong spatial dependence, which supported the use of spatial modeling. The women's asset ownership index, children's age, distance to nearest market, mothers' age, distance to nearest road, household size, child sex, region, toilet type, mother's religion, source of drinking water, and place of residence were significant factors. The results demonstrate a distinct inverse spatial correlation between women's asset ownership and child undernutrition, suggesting that women's economic empowerment functions as a protective structural part. The result of temporal validation showed a growing impact of geographic and contextual factors. Gradient-boosted trees and random forests with spatial features make it easy to model intricate nutritional outcomes in different settings. The results underline geographically targeted child nutrition programs and policies that bolster women's economic autonomy and resilience. Integrating spatial analytics and Gradient-boosted trees and random forests machine learning techniques with gender‑sensitive socioeconomic factors can strengthen precise public health strategies to reduce child undernutrition. CI - (c) 2026. The Author(s). FAU - Dessie, Dereje Bekele AU - Dessie DB AD - Department of Statistics, College of Natural and Computational Science, Madda Walabu University, Bale Robe, Ethiopia. derejebekele@hu.edu.et. AD - Department of Statistics, College of Natural and Computational Science, Hawassa University, Hawassa, Ethiopia. derejebekele@hu.edu.et. FAU - Kitawa, Yonas Shuke AU - Kitawa YS AD - Department of Statistics, College of Natural and Computational Science, Hawassa University, Hawassa, Ethiopia. FAU - Asfaw, Zeytu Gashaw AU - Asfaw ZG AD - Department of Epidemiology and Biostatistics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20260627 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Assets OT - Children OT - Machine learning OT - Undernutrition OT - Women COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The data were obtained via online registration and downloaded after the purpose of the analysis was communicated and approved. An approval for the use of the ESPS data set was gained from the World Bank Microdata Catalog: https://microdata.worldbank.org/collections/lsms. Ethics approval and participants' consent were not required, as this is publicly available data. EDAT- 2026/06/28 00:36 MHDA- 2026/06/28 00:36 CRDT- 2026/06/27 23:17 PHST- 2026/03/20 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2026/06/28 00:36 [pubmed] PHST- 2026/06/27 23:17 [entrez] AID - 10.1038/s41598-026-59905-w [pii] AID - 10.1038/s41598-026-59905-w [doi] PST - aheadofprint SO - Sci Rep. 2026 Jun 27. doi: 10.1038/s41598-026-59905-w. PMID- 42364891 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260908 IS - 1873-3492 (Electronic) IS - 0009-8981 (Linking) VI - 592 DP - 2027 Jan 1 TI - Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche. PG - 121207 LID - S0009-8981(26)00389-X [pii] LID - 10.1016/j.cca.2026.121207 [doi] AB - BACKGROUND: Distinguishing idiopathic central precocious puberty (ICPP) from premature thelarche (PT) remains a clinical challenge and often necessitates GnRH stimulation testing. Kisspeptin-10 (Kp-10), Neurokinin B (NKB), and Neuropeptide Y (NPY) are key regulators of GnRH secretion and may serve as surrogate biomarkers. We evaluated whether these neuropeptides, alone or in combination with basal gonadotropins, could provide clinically useful discrimination of ICPP and PT. METHODS: In this prospective study, Indian girls aged 6-9 years were enrolled as controls (n = 40), ICPP (n = 33), and PT (n = 23). Anthropometry, basal LH, FSH, estradiol, pelvic ultrasonography, and plasma Kp-10, NKB, and NPY levels were assessed. Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis. Logistic regression models assessed incremental predictive value: Model 1 included the Kp-10/basal LH ratio; Model 2 added bone age advancement (BA-CA); and Model 3 further included basal estradiol. Clinical utility was examined using decision curve analysis (DCA). RESULTS: Anthropometric parameters did not differ between ICPP and PT. Kp-10 and NKB levels were higher in both early-puberty groups than controls, but neither marker alone discriminated ICPP from PT. The composite Kp-10/basal LH ratio showed superior performance, with an ROC-derived cut-off <4.07 ng/mIU (sensitivity 72.7%, specificity 87.0%, accuracy 78%). All three models showed similar discrimination (AUC 0.78-0.79), with no meaningful improvement after adding BA-CA or estradiol. DCA demonstrated a higher net benefit for the Kp-10/basal LH ratio compared with treat-all or treat-none strategies across clinically relevant thresholds. CONCLUSION: The Kp-10/basal LH ratio provides robust discrimination and meaningful clinical utility in differentiating ICPP from PT and may reduce reliance on GnRH stimulation testing. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Banerjee, Antara A AU - Banerjee AA AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Bhanarkar, Shital R AU - Bhanarkar SR AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Kashikar, Swati AU - Kashikar S AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Keshwani, Rachna AU - Keshwani R AD - Bai Jerbai Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai 400 012, India. FAU - Walia, Shagun AU - Walia S AD - Bai Jerbai Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai 400 012, India. FAU - Kavya, D R AU - Kavya DR AD - Bai Jerbai Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai 400 012, India. FAU - Bombe, Shweta AU - Bombe S AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Pande, Shailesh AU - Pande S AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Modi, Deepak N AU - Modi DN AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Pathak, Bhakti R AU - Pathak BR AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Joshi, Beena AU - Joshi B AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Tandon, Deepti AU - Tandon D AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Patil, Anushree AU - Patil A AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Begum, Shahina AU - Begum S AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Mahale, Smita D AU - Mahale SD AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Rao, Sudha AU - Rao S AD - Bai Jerbai Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai 400 012, India. Electronic address: c_sudha@hotmail.com. FAU - Surve, Suchitra V AU - Surve SV AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. Electronic address: surves@nirrch.res.in. LA - eng PT - Journal Article DEP - 20260627 PL - Netherlands TA - Clin Chim Acta JT - Clinica chimica acta; international journal of clinical chemistry JID - 1302422 RN - 0 (Kisspeptins) RN - 9002-67-9 (Luteinizing Hormone) RN - 0 (KISS1 protein, human) SB - IM MH - Humans MH - *Puberty, Precocious/blood/diagnosis MH - *Kisspeptins/blood MH - Female MH - *Luteinizing Hormone/blood MH - Child MH - Prospective Studies OTO - NOTNLM OT - Idiopathic central precocious puberty OT - Kisspeptin OT - Luteinizing hormone OT - Neurokinin B OT - Premature thelarche COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/28 00:36 MHDA- 2026/09/08 23:35 CRDT- 2026/06/27 19:31 PHST- 2026/03/04 00:00 [received] PHST- 2026/06/19 00:00 [revised] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/09/08 23:35 [medline] PHST- 2026/06/28 00:36 [pubmed] PHST- 2026/06/27 19:31 [entrez] AID - S0009-8981(26)00389-X [pii] AID - 10.1016/j.cca.2026.121207 [doi] PST - ppublish SO - Clin Chim Acta. 2027 Jan 1;592:121207. doi: 10.1016/j.cca.2026.121207. Epub 2026 Jun 27. PMID- 42364851 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 226 DP - 2026 Nov 1 TI - Hedonic and practicality beliefs form a behaviour-proximal core associated with red and processed meat intake: An attitude network analysis. PG - 108694 LID - S0195-6663(26)00256-4 [pii] LID - 10.1016/j.appet.2026.108694 [doi] AB - Red and processed meat (RPM) consumption remains widespread in high-income populations despite consistent health and sustainability recommendations to reduce intake. Although attitudinal measures reliably predict meat-related intentions and intake, prior work has relied predominantly on aggregate affective and cognitive composites, which conceal how the evaluative system is organised: which evaluations are most structurally embedded, which bridge distinct clusters of meaning, and which sit closest to behaviour. We addressed this by applying an item-level Causal Attitude Network approach in a preregistered cross-sectional survey of 1554 UK adults. A regularised partial-correlation network (EBICglasso) was estimated on 21 evaluative items and a past-week RPM intake sum score; we examined community structure, node centrality, between-community connectivity, and the intake node's neighbourhood, complemented by hierarchical regressions on affective and cognitive composites. Walktrap community detection identified four communities (Hedonics, Morality, Benefits/Vitality, Practicality/Feasibility), with the intake node located within Practicality/Feasibility alongside planning, health, and sustainability-related content. The most central evaluative reactions reflected sensory reward and moral evaluation (e.g., pleasantness, tastiness, moral acceptability). Intake showed its strongest conditional association with planning, with smaller links to strength, pleasantness, sustainability, comfort, and pleasure. Between-community connectivity was concentrated in a few pathways, most notably Hedonics-Practicality/Feasibility and Practicality/Feasibility-Benefits/Vitality. Sex-stratified networks were highly similar despite higher intake among men. In regressions, the composites raised explained variance in intake from R(2) = .05 (demographics) to R(2) = .39, with a stronger association for the affective (beta = .45) than the cognitive composite (beta = .18). The architecture suggests, as hypothesis-generating rather than causal claims, that information-focused appeals about long-term consequences may have limited leverage and that intervention targets more plausibly lie in planning, feasibility, hedonic reliance, and benefit/vitality reframing. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Kraft, Pal AU - Kraft P AD - Department of Psychology, University of Oslo, P. O. Box 1094, Blindern, 0317, Oslo, Norway; Department of Psychology, Oslo New University College, Ullevalsveien 76, 0454, Oslo, Norway. Electronic address: pal.kraft@psykologi.uio.no. FAU - Kraft, Brage AU - Kraft B AD - Department of Behavioral Sciences, Oslo Metropolitan University, P. O. Box 4, St. Olavs plass, 0130, Oslo, Norway. Electronic address: brage.kraft@oslomet.no. LA - eng PT - Journal Article DEP - 20260627 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - United Kingdom MH - *Red Meat MH - *Feeding Behavior/psychology MH - Young Adult MH - *Food Preferences/psychology MH - *Meat Products MH - *Diet/psychology MH - Adolescent MH - Aged OTO - NOTNLM OT - Causal attitude network OT - Meat attitudes OT - Network analysis OT - Red meat OT - Sex differences COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/28 00:37 MHDA- 2026/08/08 00:37 CRDT- 2026/06/27 19:30 PHST- 2026/04/07 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/08/08 00:37 [medline] PHST- 2026/06/28 00:37 [pubmed] PHST- 2026/06/27 19:30 [entrez] AID - S0195-6663(26)00256-4 [pii] AID - 10.1016/j.appet.2026.108694 [doi] PST - ppublish SO - Appetite. 2026 Nov 1;226:108694. doi: 10.1016/j.appet.2026.108694. Epub 2026 Jun 27. PMID- 42364529 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260919 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 130 DP - 2026 Oct TI - Reliability and minimal detectable change of knee mechanics during gait and squatting, using markerless motion capture in the workplace. PG - 110266 LID - S0966-6362(26)00176-1 [pii] LID - 10.1016/j.gaitpost.2026.110266 [doi] AB - INTRODUCTION: Meaningful changes in joint mechanics within or across sessions require observed differences greater than measurement error. While markerless motion capture systems have achieved comparable gait parameters to marker-based methods, there is a knowledge gap for markerless approaches applied to postures adopted in the workplace in terms of reliability and minimal detectable change (MDC). OBJECTIVE: To compare within-session reliability, intersession reliability, and MDCs of peak knee angles and moments between walking and squatting in the workplace. METHODS: Three-dimensional markerless motion capture and force plates recorded gait and squat trials for twenty-one female early childhood educators [age: 41.6 yrs (10.7), BMI: 29.3 kg/m(2) (7.7); mean (SD)] before, and immediately following, their work shift. Intraclass correlation coefficients (ICC(2,2)) for reliabilities and MDCs were calculated from two trials or averages each session for peak knee flexion and peak knee adduction angles and moments. RESULTS: Within-session reliability was poor to excellent for gait (ICC(2,2)=0.24-0.94) and moderate to excellent for squats (ICC(2,2)=0.52-0.99). Intersession reliability was moderate to excellent for gait (ICC(2,2)=0.59-0.96) and poor to excellent for squats (ICC(2,2)=0.05-0.96). MDCs for peak knee joint angles and moments ranged from 1.6 to 9.9 degrees and 0.09-0.84 Nm/kg for gait, and 3.7 to 10.2 degrees and 0.05-0.24 Nm/kg for squats, respectively. DISCUSSION/CONCLUSION: Within-session and intersession reliability for peak knee outcomes was higher for squatting compared to gait, and peak knee moments had reduced within-session reliability compared to the peak knee angles. Squat peak knee flexion and adduction angles exceeded the 5 degrees MDC threshold, suggesting that larger differences are required to be interpreted as meaningful. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Hallman, Sarah M J AU - Hallman SMJ AD - Department of Kinesiology and Health Sciences, 200 University Avenue West, University of Waterloo, Waterloo, ON N2L 3G1, Canada. Electronic address: sarah.hallman@uwaterloo.ca. FAU - Peckett, Kimberly H AU - Peckett KH AD - Department of Kinesiology and Health Sciences, 200 University Avenue West, University of Waterloo, Waterloo, ON N2L 3G1, Canada. Electronic address: khpeckett@uwaterloo.ca. FAU - Acker, Stacey M AU - Acker SM AD - Department of Kinesiology and Health Sciences, 200 University Avenue West, University of Waterloo, Waterloo, ON N2L 3G1, Canada; Rehabilitation Sciences, McMaster University, Canada; Mechanical Engineering, Queen's University, Canada. Electronic address: stacey.acker@uwaterloo.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260622 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Humans MH - Female MH - Motion Capture MH - Reproducibility of Results MH - Biomechanical Phenomena MH - *Knee Joint/physiology MH - Adult MH - *Gait/physiology MH - Range of Motion, Articular/physiology MH - Workplace MH - *Posture/physiology OTO - NOTNLM OT - Early Childhood Educators OT - Knee OT - Markerless Motion Capture OT - Minimal Detectable Change OT - Reliability COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Stacey Acker reports financial support was provided by Natural Sciences and Engineering Research Council of Canada. Stacey Acker reports financial support was provided by Canadian Foundation for Innovation. Sarah Hallman reports financial support was provided by NSERC. Sarah Hallman reports financial support was provided by Ontario Ministry of Colleges and Universities. Kimberly Peckett reports financial support was provided by Natural Sciences and Engineering Research Council of Canada. Kimberly Peckett reports financial support was provided by Ontario Ministry of Colleges and Universities. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/28 00:36 MHDA- 2026/08/22 23:43 CRDT- 2026/06/27 18:08 PHST- 2026/02/06 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/06/28 00:36 [pubmed] PHST- 2026/06/27 18:08 [entrez] AID - S0966-6362(26)00176-1 [pii] AID - 10.1016/j.gaitpost.2026.110266 [doi] PST - ppublish SO - Gait Posture. 2026 Oct;130:110266. doi: 10.1016/j.gaitpost.2026.110266. Epub 2026 Jun 22. PMID- 42364424 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260901 IS - 1095-6859 (Electronic) IS - 0090-8258 (Linking) VI - 211 DP - 2026 Aug TI - PRO-PLATINUM: A randomized, double-blind, placebo controlled study to investigate the efficacy of a probiotic intervention on the gut and vaginal microbiome of ovarian cancer patients undergoing treatment with platinum chemotherapy. PG - 74-78 LID - S0090-8258(26)02036-6 [pii] LID - 10.1016/j.ygyno.2026.06.016 [doi] AB - BACKGROUND: PRO-PLATINUM evaluates whether a 5-strain probiotic formulation can favorably modulate the gut microbiome during platinum-based chemotherapy in ovarian cancer (OC), while assessing feasibility, safety, and translational correlates of response and toxicity. PATIENTS AND METHODS: PRO-PLATINUM is an IRB-approved, randomized, double-blind, placebo-controlled trial enrolling 124 patients with stage II-IV or platinum-sensitive recurrent high-grade OC receiving platinum-based chemotherapy. The study opened to enrollment in February 2026. Participants are randomized 1:1 to a 5-strain probiotic (WBF-038) or placebo, stratified by newly diagnosed advanced versus recurrent disease. The intervention contains inulin and five microbial strains: Akkermansia muciniphila, Anaerobutyricum hallii, Clostridium beijerinckii, Clostridium butyricum, and Bifidobacterium infantis, and is administered orally twice daily beginning within seven days of cycle 1 and continuing through seven days after the completion of cycle 6. Eligible patients must have ECOG performance status 0-2, adequate organ function, and no major probiotic-related contraindications. Stool, blood, and vaginal samples are collected at baseline, cycle 3, and cycle 6; tumor tissue is collected at surgery when available. The primary endpoint is change in gut microbiome composition by whole-genome metagenomic sequencing. Secondary endpoints include intervention adherence, biospecimen feasibility, recurrence-free survival, and overall survival. Exploratory endpoints include toxicity, postoperative infections, stool consistency, diet, medication and antibiotic exposure, quality of life, symptom burden, serum metabolomic and immune profiling, vaginal and tumor microbiome composition, and associations between microbial features and clinical outcomes. CONCLUSIONS: PRO-PLATINUM will evaluate treatment feasibility and safety and generate prospective translational data to inform future microbiome-directed strategies to improve treatment tolerance, quality of life, and outcomes in OC patients. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Chambers, Laura M AU - Chambers LM AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. Electronic address: laura.chambers@osumc.edu. FAU - Spakowicz, Daniel AU - Spakowicz D AD - Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Chalif, Julia AU - Chalif J AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - O'Connor, Reed AU - O'Connor R AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Kistenfeger, Quinn AU - Kistenfeger Q AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Mehra, Yogita AU - Mehra Y AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Mohssen, Mohamed AU - Mohssen M AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Abdeen, Cassidy AU - Abdeen C AD - The Ohio State University School of Medicine, USA. FAU - Haight, Paulina AU - Haight P AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Nagel, Christa AU - Nagel C AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Neff, Robert AU - Neff R AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Cohn, David AU - Cohn D AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Copeland, Larry J AU - Copeland LJ AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Backes, Floor AU - Backes F AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Cosgrove, Casey AU - Cosgrove C AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Hays, John AU - Hays J AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Dravillas, Caroline AU - Dravillas C AD - The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. FAU - McLaughlin, Eric AU - McLaughlin E AD - The Ohio State University School of Medicine, Department of Biostatistics, USA. FAU - O'Malley, David AU - O'Malley D AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260627 PL - United States TA - Gynecol Oncol JT - Gynecologic oncology JID - 0365304 RN - Q20Q21Q62J (Cisplatin) SB - IM MH - Humans MH - Female MH - Double-Blind Method MH - *Probiotics/administration & dosage/therapeutic use MH - *Ovarian Neoplasms/drug therapy/microbiology/pathology MH - *Gastrointestinal Microbiome/drug effects MH - *Vagina/microbiology MH - Middle Aged MH - Adult MH - *Antineoplastic Combined Chemotherapy Protocols/therapeutic use MH - *Microbiota/drug effects MH - Aged MH - Cisplatin/administration & dosage COIS- Declaration of competing interest The authors have no relevant conflicts of interest. EDAT- 2026/06/28 04:09 MHDA- 2026/08/08 00:37 CRDT- 2026/06/27 18:06 PHST- 2026/06/12 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/08/08 00:37 [medline] PHST- 2026/06/28 04:09 [pubmed] PHST- 2026/06/27 18:06 [entrez] AID - S0090-8258(26)02036-6 [pii] AID - 10.1016/j.ygyno.2026.06.016 [doi] PST - ppublish SO - Gynecol Oncol. 2026 Aug;211:74-78. doi: 10.1016/j.ygyno.2026.06.016. Epub 2026 Jun 27. PMID- 42364371 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260911 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 258 DP - 2026 Sep TI - Age-dependent performance of obesity measures in screening for cardiometabolic risk over the lifespan. PG - 106399 LID - S0033-3506(26)00268-4 [pii] LID - 10.1016/j.puhe.2026.106399 [doi] AB - OBJECTIVES: To evaluate age-specific associations of body mass index (BMI) and waist-to-height ratio (WHtR) with cardiometabolic risk and to explore potential age- and sex-specific screening thresholds. STUDY DESIGN: This cross-sectional study included 58,712 participants from the NHANES in the United States from 1999 to 2020. METHODS: Using data from 58,712 participants (aged 12-85 years) from NHANES 1999-2020, we analyzed age-stratified associations between obesity metrics (BMI, WHtR) and cardiometabolic risk (hypertension, dyslipidemia, diabetes). We used subsample population weights to produce estimates representative of the U.S. POPULATION: Covariates included demographics, lifestyle, socioeconomic factors, and medication use. Logistic regression, receiver operating characteristic (ROC) curves, and population attributable fraction were used. Exploratory age- and sex-specific screening thresholds were estimated using Youden's index. RESULTS: ROC analysis suggested that the discriminative performance of both BMI and WHtR for identifying prevalent cardiometabolic risk decreased with increasing age. The association between adiposity measures and prevalent cardiometabolic risk appeared to attenuate with age, as reflected by lower odds ratios and population attributable fractions. Nonlinear, J-shaped cross-sectional associations of BMI and WHtR with cardiometabolic risk were observed, particularly among older adults, in whom the risk appeared to plateau at higher adiposity levels. The screening performance of conventional obesity thresholds varied across age groups. The exploratory age- and sex-specific thresholds based on the maximum Youden index showed relatively balanced sensitivity and specificity, but require prospective validation. CONCLUSIONS: BMI and WHtR exhibited nonlinear associations with cardiometabolic risk. The strength of these associations and their discriminative performance appeared to decrease with age, suggesting that age- and sex-specific screening thresholds may warrant further investigation. CI - Copyright (c) 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Xue, Yongxi AU - Xue Y AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Qi, Qianjin AU - Qi Q AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Gao, Chaonan AU - Gao C AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Meng, Xin AU - Meng X AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Liu, Wei AU - Liu W AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Yan, Yinkun AU - Yan Y AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address: ykyan2011@163.com. LA - eng PT - Journal Article DEP - 20260627 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Cross-Sectional Studies MH - Aged MH - *Obesity/epidemiology/diagnosis MH - Adult MH - Adolescent MH - Body Mass Index MH - Aged, 80 and over MH - United States/epidemiology MH - Young Adult MH - *Cardiometabolic Risk Factors MH - Waist-Height Ratio MH - Nutrition Surveys MH - Child MH - Age Factors MH - *Cardiovascular Diseases/epidemiology MH - *Mass Screening OTO - NOTNLM OT - BMI OT - Cardiometabolic risk OT - Life-course epidemiology OT - Obesity OT - Waist-to-height ratio COIS- Declaration of competing interests The authors declared no conflict of interest. EDAT- 2026/06/28 04:09 MHDA- 2026/09/11 23:36 CRDT- 2026/06/27 18:04 PHST- 2025/11/02 00:00 [received] PHST- 2026/05/15 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/09/11 23:36 [medline] PHST- 2026/06/28 04:09 [pubmed] PHST- 2026/06/27 18:04 [entrez] AID - S0033-3506(26)00268-4 [pii] AID - 10.1016/j.puhe.2026.106399 [doi] PST - ppublish SO - Public Health. 2026 Sep;258:106399. doi: 10.1016/j.puhe.2026.106399. Epub 2026 Jun 27. PMID- 42363975 OWN - NLM STAT- Publisher LR - 20260702 IS - 1432-0932 (Electronic) IS - 0940-6719 (Linking) DP - 2026 Jun 27 TI - Comment on "Responsiveness and minimal clinically important changes of surface topography parameters in adolescents with idiopathic scoliosis: results from the schroth exercise trial". LID - 10.1007/s00586-026-10140-x [doi] AB - OBJECTIVE: To offer constructive comments on the recent study by Mohamed et al. published in European Spine Journal, with a focus on the clinical detectability of the proposed minimal clinically important changes (MCICs) for surface topography (ST) parameters, the robustness of the anchoring method, and the differential responsiveness between thoracic and lumbar curve subgroups, aiming to provide reference for future research on ST application in conservative management of adolescent idiopathic scoliosis (AIS). METHODS: This commentary was developed through logical analysis of the original study data and cross-referencing with existing literature, addressing three key aspects: (1) a theoretical comparison between the reported MCIC values and the inherent measurement error (minimal detectable change, MDC) of ST systems to evaluate their clinical discriminability; (2) an examination of the limitations of using the Global Rating of Change (GRC) scale as a single anchoring tool, with suggestions for incorporating the SRS-22 self-image domain and region-specific parameters as complementary measures; and (3) an interpretation of the discordance between ST parameter changes and patient perception in the thoracic subgroup, supported by independent evidence from postoperative AIS studies on the correlation between radiographic parameters and self-image RESULTS: The MCIC values proposed in the original study-0.27 mm for RMS and 0.49 mm for MaxDev-are substantially smaller than the known measurement errors of most ST systems. Without reporting the MDC, such "clinically important" changes may be indistinguishable from random noise. The correlation between GRC scores and ST parameter changes was only moderate (r approximately -0.5), and the use of a single global parameter failed to capture shoulder and waist asymmetries, limiting its ability to reflect clinically meaningful improvement in thoracic curves. Independent postoperative evidence supports the authors' hypothesis that lumbar curve changes are more readily perceived by patients, as residual thoracolumbar/lumbar curve magnitude, but not the main thoracic curve, correlates with SRS-22 self-image scores. CONCLUSION: The original study provides pioneering data on ST parameters in AIS; however, the clinical application of its MCIC values warrants cautious interpretation. Future studies should systematically report MDC to establish measurement reliability, employ multi-dimensional anchoring tools (e.g., SRS-22), and develop region-specific or composite ST parameters, particularly optimized for patients with thoracic curves, to more accurately capture patient-perceived clinical improvement. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Zhu, Hai AU - Zhu H AD - Graduate School of Gansu University of Traditional Chinese Medicine, Gansu, China. FAU - Wang, Zhengping AU - Wang Z AD - Graduate School of Gansu University of Traditional Chinese Medicine, Gansu, China. FAU - Feng, Yiwen AU - Feng Y AD - Graduate School of Gansu University of Traditional Chinese Medicine, Gansu, China. FAU - Liu, Yongming AU - Liu Y AD - Department of Spinal and Orthopedic Surgery IV, Gansu Provincial Hospital of Traditional Chinese Medicine, Gansu, China. Lymgszyydx123@163.com. LA - eng PT - Journal Article PT - Review DEP - 20260627 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Clinical outcome assessment OT - Minimal clinically important change OT - Minimal detectable change OT - Schroth exercises OT - Surface topography COIS- Declarations. Conflict of interests: The authors declare no competing interests. EDAT- 2026/06/27 12:38 MHDA- 2026/06/27 12:38 CRDT- 2026/06/27 11:04 PHST- 2026/06/16 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/27 12:38 [pubmed] PHST- 2026/06/27 12:38 [medline] PHST- 2026/06/27 11:04 [entrez] AID - 10.1007/s00586-026-10140-x [pii] AID - 10.1007/s00586-026-10140-x [doi] PST - aheadofprint SO - Eur Spine J. 2026 Jun 27. doi: 10.1007/s00586-026-10140-x. PMID- 42363556 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260916 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 26 DP - 2026 Jun 26 TI - Association between body fat indices and female infertility: A cross-sectional study. PG - e49327 LID - 10.1097/MD.0000000000049327 [doi] LID - e49327 AB - Excess body fat and its distribution are known to influence female reproductive function; however, the relationship between emerging body fat-related indices and infertility remains insufficiently explored. This study aimed to investigate the association between the Conicity Index (C-index), Relative Fat Mass (RFM), and Metabolic Score for Visceral Fat (METS-VF) and infertility among women of reproductive age in the United States. The study included women aged 18 to 45 years and assessed infertility using the National Health and Nutrition Examination Survey question RHQ074 on reproductive health. Multivariable logistic regression, adjusted for confounders, was used to analyze the association between body fat indices and infertility risk. Receiver operating characteristic curve analysis was conducted to evaluate each metric's predictive strength. Of 1103 women, 132 reported infertility. Infertile women had higher C-index (1.3 vs 1.27), RFM (43 vs 40), and METS-VF (8.24 vs 7.37) than fertile women. Each 1-unit increase in these indices was associated with higher odds of infertility (C-index odds ratio [OR] = 2.73, RFM OR = 1.07, METS-VF OR = 1.28). METS-VF had the highest predictive value (area under the curve = 0.65), as confirmed by random forest analysis. Positive associations between infertility and C-index, RFM, and METS-VF suggest that these indices could help assess infertility risk and support targeted reproductive health interventions. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Huang, Li AU - Huang L AD - Academy for Educational Development and Innovation, The Education University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Puding No. 2 Middle School, Anshun, Guizhou, People's Republic of China. FAU - Yang, Wei Jing AU - Yang WJ AUID- ORCID: 0009-0003-6704-7014 AD - Department of Gynecology, Puding County People's Hospital, Anshun, Guizhou, People's Republic of China. FAU - Kuang, Gui Rong AU - Kuang GR AD - Department of Reproductive Medicine, Anshun People's Hospital, Anshun, Guizhou, People's Republic of China. FAU - Li, Xiang Yan AU - Li XY AD - Department of Gynecology, Puding County People's Hospital, Anshun, Guizhou, People's Republic of China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Female MH - *Infertility, Female/epidemiology/etiology MH - Cross-Sectional Studies MH - Adult MH - Body Mass Index MH - Intra-Abdominal Fat MH - Nutrition Surveys MH - Middle Aged MH - Young Adult MH - United States/epidemiology MH - ROC Curve MH - Adolescent MH - Risk Factors MH - Obesity/complications MH - *Adipose Tissue PMC - PMC13313760 OTO - NOTNLM OT - Conicity Index (C-index) OT - Metabolic Score for Visceral Fat (METS-VF) OT - NHANES OT - Relative Fat Mass Index (RFM) OT - infertility COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/06/27 10:10 MHDA- 2026/06/28 10:11 PMCR- 2026/06/26 CRDT- 2026/06/27 01:00 PHST- 2026/02/02 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/28 10:11 [medline] PHST- 2026/06/27 10:10 [pubmed] PHST- 2026/06/27 01:00 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 00005792-202606260-00109 [pii] AID - MD-D-26-01949 [pii] AID - 10.1097/MD.0000000000049327 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 26;105(26):e49327. doi: 10.1097/MD.0000000000049327. PMID- 42363543 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260916 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 26 DP - 2026 Jun 26 TI - Serum total bilirubin and childhood asthma: Results of the NHANES 2007-2018 and Mendelian randomization study. PG - e49528 LID - 10.1097/MD.0000000000049528 [doi] LID - e49528 AB - Total bilirubin possesses antioxidant and immunomodulatory properties, and its role in childhood asthma is a topic of ongoing debate. We employed both a cross-sectional study and Mendelian randomization (MR) analysis to explore the link between serum total bilirubin and childhood asthma. In the cross-sectional study from the National Health and Nutrition Examination Survey 2007 to 2018, weighted logistic regression models were utilized to investigate the association between serum total bilirubin and childhood asthma. We also used restricted cubic splines to explore the dose-response relationship between the 2. The inverse-variance weighted method was used as the main method of MR analysis to explore the causal effect of exposure on outcomes. A total of 3238 participants were included in the cross-sectional study. Weighted logistic regression analysis encompassing all participants revealed no significant association between total bilirubin levels and the risk of childhood asthma (P > .05). The same results were obtained after categorizing participants into tertiles based on total bilirubin levels. The restricted cubic splines curve revealed an S-shaped relationship between total bilirubin levels and childhood asthma. MR analysis reveals no causal association between serum total bilirubin and childhood asthma (odds ratio [OR] = 0.974, P = .752), peak expiratory flow (OR = 1.002, P = .831), and forced expiratory volume in 1-second (OR = 1.005, P = .554). Our study did not support a causal relationship between serum total bilirubin and childhood asthma. Further studies with a larger number of cases are crucial to validate our findings. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - He, Lijun AU - He L AD - Department of Ultrasound, The Second Affiliated Hospital of Army Medical University, Chongqing, China. FAU - Wang, Kang AU - Wang K AUID- ORCID: 0000-0002-0967-3872 AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Army Medical University, Chongqing, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - RFM9X3LJ49 (Bilirubin) SB - IM MH - Humans MH - *Bilirubin/blood MH - *Asthma/blood/epidemiology/genetics MH - Female MH - Cross-Sectional Studies MH - Mendelian Randomization Analysis MH - Male MH - Nutrition Surveys MH - Child MH - Logistic Models MH - Risk Factors PMC - PMC13313767 OTO - NOTNLM OT - Mendelian randomization OT - National Health and Nutrition Examination Survey OT - childhood asthma OT - correlation OT - serum total bilirubin COIS- The authors have no funding or conflicts of interest to disclose. EDAT- 2026/06/27 10:10 MHDA- 2026/06/28 16:09 PMCR- 2026/06/26 CRDT- 2026/06/27 01:00 PHST- 2025/07/22 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/06/28 16:09 [medline] PHST- 2026/06/27 10:10 [pubmed] PHST- 2026/06/27 01:00 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 00005792-202606260-00096 [pii] AID - MD-D-25-09095 [pii] AID - 10.1097/MD.0000000000049528 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 26;105(26):e49528. doi: 10.1097/MD.0000000000049528. PMID- 42363402 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 1097-4598 (Electronic) IS - 0148-639X (Print) IS - 0148-639X (Linking) VI - 74 IP - 3 DP - 2026 Sep TI - The Use of the Four Square Step Test and the 10-m Walk/Run Test to Determine Fall Risk in Children With Duchenne Muscular Dystrophy. PG - 740-746 LID - 10.1002/mus.70325 [doi] AB - INTRODUCTION/AIMS: The identification of the risk of falling in Duchenne muscular dystrophy (DMD) is essential for the implementation of timely preventive approaches. This study aimed to examine the ability of the four square step test (FSST) and the 10-m walk/run test (10MWRT) to discriminate between fallers and non-fallers in children with DMD. METHODS: Ninety-five children with DMD were included in this study. Functional level was determined with the Vignos Scale. Children who had fallen at least once in the previous month were categorized as "fallers" (n = 50), while those who had not fallen were categorized as "non-fallers" (n = 45). The FSST and 10MWRT were performed. The Mann-Whitney U test was performed to examine group differences in the FSST and 10MWRT scores. The predictive values of the FSST and 10MWRT were determined with receiver operating characteristic curves. RESULTS: The demographic characteristics of fallers (median age: 9.50 years; median body mass index [BMI]: 19.02 kg/m(2)) and non-fallers (median age: 9.00 years; median BMI: 17.95) were similar (p > 0.05). Fallers demonstrated lower functional levels compared with non-fallers (p < 0.001). The FSST for fallers was 20.04 +/- 12.57 s while that for non-fallers was 11.44 +/- 2.94 s with a cut-off point of 13.10 s (p < 0.05). The 10MWRT for fallers and non-fallers were 9.42 +/- 4.77 and 5.36 +/- 2.10 s, respectively, with a cut-off point of 5.60 s (p < 0.05). DISCUSSION: The two outcome measures were shown to be sensitive and specific in determining the risk of falls in children with DMD. The cut-off points may guide professionals in planning a proactive rehabilitation program to reduce fall risk or minimize subsequent injuries. CI - (c) 2026 The Author(s). Muscle & Nerve published by Wiley Periodicals LLC. FAU - Bulut, Numan AU - Bulut N AUID- ORCID: 0000-0001-5427-1103 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. FAU - Aldirmaz, Esra AU - Aldirmaz E AUID- ORCID: 0000-0003-2132-4541 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. AD - Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Final International University, Mersin, Turkey. FAU - Alemdaroglu-Gurbuz, Ipek AU - Alemdaroglu-Gurbuz I AUID- ORCID: 0000-0001-5556-6608 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. FAU - Tunca, Oznur AU - Tunca O AUID- ORCID: 0000-0002-0855-9541 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Muscle Nerve JT - Muscle & nerve JID - 7803146 SB - IM MH - Humans MH - *Muscular Dystrophy, Duchenne/physiopathology/diagnosis MH - *Accidental Falls/prevention & control MH - Child MH - Male MH - *Walking/physiology MH - Female MH - *Exercise Test/methods MH - ROC Curve MH - *Walk Test/methods MH - Adolescent PMC - PMC13471885 OTO - NOTNLM OT - fall OT - gait OT - muscular dystrophy OT - physical therapy OT - timed functional test COIS- The authors declare no conflicts of interest. EDAT- 2026/06/27 10:10 MHDA- 2026/08/13 12:42 PMCR- 2026/08/13 CRDT- 2026/06/27 00:04 PHST- 2026/05/21 00:00 [revised] PHST- 2025/06/29 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/08/13 12:42 [medline] PHST- 2026/06/27 10:10 [pubmed] PHST- 2026/06/27 00:04 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - MUS70325 [pii] AID - 10.1002/mus.70325 [doi] PST - ppublish SO - Muscle Nerve. 2026 Sep;74(3):740-746. doi: 10.1002/mus.70325. Epub 2026 Jun 26. PMID- 42363297 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260923 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Jun 26 TI - Effects of an infant formula containing a whey protein concentrate on feeding tolerance and markers of intestinal immune defense in Chinese infants. LID - 10.1186/s40795-026-01395-0 [doi] LID - 194 AB - BACKGROUND: Human milk (HM) bioactive components can have immune modulatory functions, impact the gut microbiome, and may result in functional benefits when added to infant formula (IF). In this single-arm, prospective, intervention study, we tested the effectiveness of an IF with a whey protein concentrate co-enriched in alpha-lactalbumin, milk fat globule membrane (MFGM), and Sn-2 palmitate resulting in protein and lipid profiles observed in HM. The outcomes tested were feeding tolerance, Bifidobacteria abundance, and intestinal and immune health of Chinese infants. METHODS: Predominantly formula-fed (FF) and breastfed (BF) infants were enrolled between 3 and 28 days and assigned to the FF (N = 60) or BF (N = 60) group, per their feeding practice, for 6 weeks. The primary endpoint was Infant Gastrointestinal Symptom Questionnaire (IGSQ) index score assessed using a validated IGSQ-13 questionnaire after 6 weeks of intervention; non-inferiority of FF vs BF was tested. Secondary endpoints included fecal Bifidobacteria abundance assessed using shotgun metagenomics sequencing; fecal short chain fatty acids (SCFAs) analyzed by ultra-performance liquid chromatography-tandem mass spectrometry; fecal markers of immune response, inflammation, intestinal barrier integrity (secretory immunoglobulin A sIgA), cytokines, calprotectin, alpha1 antitrypsin, lipocalin-2) assessed using enzyme-linked immunosorbent assay; stool consistency assessed using gastrointestinal (GI) diary; anthropometric assessments; quality of life; physician reported adverse events; and use of medications. RESULTS: Good GI tolerance was observed in both groups at V2 (mean +/- SD IGSQ score FF: 19.9 +/- 7.4; BF: 16.8 +/- 4.2); difference of means 1.35 [95% CI: -1.312, 4.012]). After 6 weeks, Bifidobacterium genus relative abundance was not significantly different between the groups. Total SCFAs were significantly higher (p < 0.05) in the FF versus BF group, driven by increased levels of valeric and propanoic acids (p < 0.05 for both). The IGSQ domain scores, stool consistency, fecal markers of immunity, inflammation, and intestinal barrier integrity (except lipocalin-2 which was significantly higher in BF vs FF), anthropometric Z-scores, common illnesses, antibiotic use, and adverse events were not significantly different between groups at week 6. CONCLUSIONS: Our results support the effectiveness of this tested infant formula in supporting good GI tolerance, growth, specific intestinal and immune health markers, and Bifidobacteria abundance similar to that of the BF group. TRIAL REGISTRATION: NCT04880083 (2021-05-06). CI - (c) 2026. The Author(s). FAU - Wang, Ying AU - Wang Y AD - Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Min AU - Liu M AD - Shanghai Public Health Clinical Centre, Shanghai, China. FAU - Dogra, Shaillay Kumar AU - Dogra SK AD - Nestle Research, Societe Des Produits Nestle SA, 1000, Lausanne 26, Switzerland. FAU - Vidal, Karine AU - Vidal K AD - Nestle Research, Societe Des Produits Nestle SA, 1000, Lausanne 26, Switzerland. FAU - Godin, Jean-Philippe AU - Godin JP AD - Nestle Research, Societe Des Produits Nestle SA, 1000, Lausanne 26, Switzerland. FAU - Darwish, Noura AU - Darwish N AD - Clinical Research Unit, Societe Des Produits Nestle SA, 1000, Lausanne, Switzerland. FAU - Wei, Xiaona AU - Wei X AD - Nestle Research, Societe Des Produits Nestle SA, Singapore, 618802, Singapore. FAU - Reymond, Lucas AU - Reymond L AD - Clinical Research Unit, Societe Des Produits Nestle SA, 1000, Lausanne, Switzerland. FAU - Li, Qiaoji AU - Li Q AD - Nestle R&D (China) Ltd, Beijing, 100016, China. FAU - Dong, Jie AU - Dong J AD - Wyeth Nutrition, Shanghai, 200040, China. FAU - Vyllioti, Aikaterini Themis AU - Vyllioti AT AD - Clinical Research Unit, Societe Des Produits Nestle SA, 1000, Lausanne, Switzerland. FAU - Bettler, Jodi AU - Bettler J AD - Nestle Product Technology Center-Nutrition, Societe Des Produits Nestle SA, 1800, Vevey, Switzerland. FAU - Kennedy, Elaine AU - Kennedy E AD - Nestle Development Centre Nutrition, Wyeth Nutritionals Ireland Ltd., Askeaton, Co. Limerick, Ireland. FAU - Wang, Keqing AU - Wang K AD - BGI-Shenzhen, Shenzhen, 518083, China. FAU - Zhai, Qiangrong AU - Zhai Q AD - BGI-Shenzhen, Shenzhen, 518083, China. FAU - O'Regan, Jonathan AU - O'Regan J AD - Nestle Development Centre Nutrition, Wyeth Nutritionals Ireland Ltd., Askeaton, Co. Limerick, Ireland. FAU - Samuel, Tinu Mary AU - Samuel TM AD - Nestle Product Technology Center-Nutrition, Societe Des Produits Nestle SA, 1800, Vevey, Switzerland. FAU - Cai, Wei AU - Cai W AD - Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. caiw204@sjtu.edu.cn. AD - Shanghai Institute of Pediatric Research, Shanghai, China. caiw204@sjtu.edu.cn. LA - eng SI - ClinicalTrials.gov/NCT04880083 PT - Journal Article DEP - 20260626 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13591888 OTO - NOTNLM OT - Bifidobacteria OT - Sn-2-palmitate OT - Gastrointestinal tolerance OT - Growth OT - Infant formula OT - Intestinal and immune health OT - MFGM OT - alpha-lactalbumin COIS- Declarations. Ethics approval and consent to participate: This study was approved by the ethics committees at the two institutions in China which were the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (XHEC-C-2020-053-1, and the Ethics Committee of Shanghai Public Health Clinical Center (2020-E151-01, respectively and conducted in compliance with the Declaration of Helsinki and the International Conference on Harmonization Guidelines for Good Clinical Practice. This study was also approved by the Human Genetic Resource Administrative Committee of the Ministry of Science and Technology of China according to the applicable regulation before the study was initiated. Prior to enrollment, parent(s)/legally authorized representative provided written informed consent. This trial was registered on ClinicalTrials.gov (NCT04880083). Competing interests: TMS, SKD, KV, JPG, ND, XW, LR, QL, JD, JB, EK, and JR are employees of Societe des Produits Nestle S.A., the sponsors of this trial. ATV was an employee of Societe des Produits Nestle S.A. at the time the study was conducted. KW, QZ are employees of Beijing Genomics Institute, with whom Nestle had a service agreement. YW, ML and WC received a grant from Nestle to conduct the study. The investigational products were provided by Wyeth Nutritional (China) Co., Limited. Consent for publication: Not applicable as the manuscript does not contain data from any individual person. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:11 PMCR- 2026/06/26 CRDT- 2026/06/26 23:51 PHST- 2024/05/08 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/27 04:11 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:51 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.1186/s40795-026-01395-0 [pii] AID - 1395 [pii] AID - 10.1186/s40795-026-01395-0 [doi] PST - epublish SO - BMC Nutr. 2026 Jun 26;12(1):194. doi: 10.1186/s40795-026-01395-0. PMID- 42362956 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 7 DP - 2026 Jun 27 TI - Feasibility of image-based 3D avatar anthropometry assessment of pediatric obesity: a pilot study. LID - 534 [pii] LID - 10.1007/s00431-026-07187-9 [doi] AB - The purpose of this study is to evaluate the feasibility and validity of 3D avatar-based anthropometry for assessing anthropometric indicators of overweight and obesity in children based on artificial intelligence-derived 3D body reconstruction. This cross-sectional study included 171 children aged 8-10 years from five primary schools in southern Spain. Due to technical constraints of the reconstruction software, 75 children meeting predefined image quality and body weight requirements (>/= 30 kg) were eligible for 3D avatar analysis. Manual anthropometric measurements were obtained following International Society for the Advancement of Kinanthropometry (ISAK) standards and compared with avatar-derived circumferences. Agreement was assessed by using Wilcoxon tests, Spearman correlations, Bland-Altman analyses, and false discovery rate-adjusted comparisons. Avatar-derived circumferences were consistently greater than manual measurements, although waist-to-hip and waist-to-stature ratios demonstrated no significant differences. Avatar and manual circumferences were moderately to strongly correlated (Spearman's rho = 0.62-0.72; adjusted p < 0.05). However, the mean absolute errors ranged from 6.21 to 7.11 cm, and Bland-Altman analysis revealed systematic overestimation with wide limits of agreement, particularly for waist and hip circumferences. Despite these discrepancies, both methods similarly discriminated between weight status categories. CONCLUSION: Image-based 3D avatar anthropometry is a feasible, noninvasive approach for population-level screening and research in pediatric settings. Although the system reliably captures relative differences and body proportions, its current accuracy is insufficient for individual-level clinical assessment. Further algorithmic refinement and validation in lighter and more diverse pediatric populations are needed before clinical implementation. WHAT IS KNOWN: * Childhood obesity remains a major public health challenge requiring accurate monitoring. * Anthropometric assessment still relies mainly on manual measurements, while AI-based 3D body modeling offers a promising non-invasive alternative. WHAT IS NEW: * Image-based 3D avatar anthropometry is feasible in school settings but is constrained by technical requirements. * Avatar measurements are correlated with manual anthropometry and preserve weight status discrimination but demonstrate systematic overestimation and limited agreement. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Del Mar Ucles-Torrente, Maria AU - Del Mar Ucles-Torrente M AUID- ORCID: 0009-0005-3057-9062 AD - Department of Nursing, Pharmacology and Physiotherapy, University of Cordoba, Campus Menendez Pidal, 14071, Cordoba, Spain. AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. AD - Biomedicine Program, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. FAU - Ruiz-Gamarra, Gema Esperanza AU - Ruiz-Gamarra GE AUID- ORCID: 0009-0000-6124-2896 AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. AD - Biomedicine Program, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. AD - Clinical Management Unit, Health Center, Dr. Trujillo Street, Palma del Rio, 14700, Cordoba, Spain. FAU - Alcalde-Llergo, Jose Manuel AU - Alcalde-Llergo JM AUID- ORCID: 0000-0002-3607-260X AD - Computer Science, University of Cordoba, Campus de Rabanales, 14071, Cordoba, Andalucia, Spain. FAU - Vaquero-Alvarez, Manuel AU - Vaquero-Alvarez M AUID- ORCID: 0000-0001-9730-6310 AD - GC09 Nutrigenomics, Metabolic Syndrome, Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. AD - Faculty of Medicine and Nursing, University of Cordoba, 14071, Cordoba, Spain. FAU - Blancas-Sanchez, Isabel Maria AU - Blancas-Sanchez IM AD - GC09 Nutrigenomics, Metabolic Syndrome, Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. AD - Occidente Azahara Healthcare Center Cordoba, 14011, Cordoba, Spain. FAU - Aparicio-Martinez, Pilar AU - Aparicio-Martinez P AD - Department of Nursing, Pharmacology and Physiotherapy, University of Cordoba, Campus Menendez Pidal, 14071, Cordoba, Spain. n32apmap@uco.es. AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. n32apmap@uco.es. FAU - Vaquero-Abellan, Manuel AU - Vaquero-Abellan M AUID- ORCID: 0000-0002-0602-317X AD - Department of Nursing, Pharmacology and Physiotherapy, University of Cordoba, Campus Menendez Pidal, 14071, Cordoba, Spain. AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. LA - eng PT - Journal Article DEP - 20260627 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - Pilot Projects MH - *Avatar MH - Female MH - Feasibility Studies MH - Male MH - *Anthropometry/methods MH - Cross-Sectional Studies MH - *Imaging, Three-Dimensional/methods MH - *Pediatric Obesity/diagnosis MH - Spain MH - Reproducibility of Results MH - Artificial Intelligence OTO - NOTNLM OT - 3D avatar-based anthropometry OT - Modeling OT - Obesity OT - Pediatric OT - Photometric COIS- Declarations. Ethical Approval: The study was approved by the Bioethics Committee of the Reina Sofia University Hospital of Cordoba (Approval number: 5864). Informed consent: All of the participants and their parents/legal guardians received detailed information about the objectives, risks, and benefits of the study and provided written informed consent. Participation was voluntary, and participants could withdraw at any time without justification. Consent to participate: All of the participants provided consent to participate. Consent to publish: All of the participants gave permission for data use and later publication. Competing interests: The authors declare no competing interest. EDAT- 2026/06/27 00:58 MHDA- 2026/06/28 07:10 CRDT- 2026/06/26 23:26 PHST- 2026/01/22 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/28 07:10 [medline] PHST- 2026/06/27 00:58 [pubmed] PHST- 2026/06/26 23:26 [entrez] AID - 10.1007/s00431-026-07187-9 [pii] AID - 10.1007/s00431-026-07187-9 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jun 27;185(7):534. doi: 10.1007/s00431-026-07187-9. PMID- 42362911 OWN - NLM STAT- Publisher LR - 20260726 IS - 1559-064X (Electronic) IS - 1559-0631 (Linking) DP - 2026 Jun 26 TI - Diet and mycoestrogen exposure in a pregnancy cohort: the Jersey Babies pilot study. LID - 10.1038/s41370-026-00940-0 [doi] AB - BACKGROUND: Zearalenone (ZEN) is a grain-contaminating mycotoxin and potent estrogen receptor agonist linked to reproductive and perinatal disruption in animal models, with emerging epidemiologic evidence in humans. Despite widespread U.S. exposure, dietary sources remain unclear. OBJECTIVE: This pilot study assessed prenatal mycoestrogen exposure and related dietary sources in a U.S. pregnant cohort. METHODS: Pregnant women (n = 33) recruited in New Brunswick, NJ provided urine samples and completed time-matched 24-h dietary recalls at three points across pregnancy (Visit 1: 18-20 weeks; Visit 2: 24-26 weeks and Visit 3: 28-32 weeks gestation). Urinary mycoestrogens were quantified using LC/MSMS and corrected for specific gravity. RESULTS: At least one ZEN metabolite was detected in every sample (Visit, median: 1: 0.058 ng/mg; 2: 0.042 ng/mg; 3: 0.055 ng/mg), and intraclass correlation coefficients among detected metabolites ranged from 0.62 to 0.95. Across visits, Hispanic participants (39%) had 52-109% higher mycoestrogen concentrations compared to non-Hispanic participants (p < 0.05). Consumption of corn and other grain products within the past 24 h was strongly correlated with urinary concentrations of ZEN and its metabolites (r: 0.30-0.92; p < 0.05), with weaker positive correlations observed for oils and popcorn. SIGNIFICANCE: Given robust toxicologic evidence and emerging epidemiologic findings suggesting adverse maternal and child health impacts, identifying key exposure pathways is critical. IMPACT: This pilot study identifies corn and cereal-based foods as key contributors to ZEN prenatal exposure and highlights higher concentrations among Hispanic participants. By clarifying exposure pathways, these findings support improved food-safety monitoring and targeted strategies to reduce endocrine-disrupting chemical exposures during pregnancy. CI - (c) 2026. The Author(s). FAU - Rivera-Nunez, Zorimar AU - Rivera-Nunez Z AUID- ORCID: 0000-0002-0718-1807 AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. zorimar.nunez@rutgers.edu. AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. zorimar.nunez@rutgers.edu. FAU - Kinkade, Carolyn W AU - Kinkade CW AUID- ORCID: 0000-0002-8549-5553 AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. FAU - Juenke, Alyssa AU - Juenke A AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Hansel, Megan AU - Hansel M AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. FAU - Heltberg, Daniel AU - Heltberg D AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. AD - School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK. FAU - Sharada, Aditi AU - Sharada A AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. FAU - Anthony, Shabree AU - Anthony S AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Brinker, Anita AU - Brinker A AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Fields, Jessica AU - Fields J AD - Department of Obstetrics and Gynecology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA. FAU - Rosen, Todd AU - Rosen T AD - Department of Obstetrics and Gynecology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA. FAU - Palomares, Kristy AU - Palomares K AD - Department of Obstetrics and Gynecology, St. Peter's University Hospital, New Brunswick, NJ, USA. FAU - Buckley, Brian AU - Buckley B AUID- ORCID: 0000-0001-7336-4321 AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Aleksunes, Lauren M AU - Aleksunes LM AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. AD - Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA. FAU - Barrett, Emily S AU - Barrett ES AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. LA - eng GR - P30 ES005022/ES/NIEHS NIH HHS/United States GR - R01 ES037903/ES/NIEHS NIH HHS/United States GR - T32 ES007148/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20260626 PL - United States TA - J Expo Sci Environ Epidemiol JT - Journal of exposure science & environmental epidemiology JID - 101262796 SB - IM OTO - NOTNLM OT - Biomonitoring OT - Dietary exposure OT - Mycoestrogen OT - Mycotoxin OT - Pregnancy OT - Zearalenone COIS- Competing interests: ZRN, CWK, LMA and ESB mycoestrogen work has been funded by the NIH. Other authors declare no potential competing interests. Ethical approval: All study protocols were approved by the Rutgers and SPUH Institutional Review Boards and participants signed written informed consent before engaging in any study activities. EDAT- 2026/06/27 00:49 MHDA- 2026/06/27 00:49 CRDT- 2026/06/26 23:25 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/27 00:49 [medline] PHST- 2026/06/27 00:49 [pubmed] PHST- 2026/06/26 23:25 [entrez] AID - 10.1038/s41370-026-00940-0 [pii] AID - 10.1038/s41370-026-00940-0 [doi] PST - aheadofprint SO - J Expo Sci Environ Epidemiol. 2026 Jun 26. doi: 10.1038/s41370-026-00940-0. PMID- 42362794 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261016 IS - 1432-1084 (Electronic) IS - 0938-7994 (Print) IS - 0938-7994 (Linking) VI - 36 IP - 11 DP - 2026 Nov TI - Does adding a high-resolution 3D sequence improve the accuracy of erosion detection in pediatric sacroiliac joint MRI? PG - 8062-8071 LID - 10.1007/s00330-026-12709-y [doi] AB - OBJECTIVE: To evaluate whether adding an erosion-sensitive high-resolution 3D sequence to sacroiliac joint (SIJ) MRI protocols in children improves erosion detection and diagnosis of Juvenile Spondyloarthritis (JSpA). MATERIALS AND METHODS: SIJ-MRI were prospectively obtained in 84 children (50 girls, mean age 13.3 y) clinically suspected of JSpA, conforming to 2024 ASAS/SPARTAN recommendations including a volumetric interpolated breath-hold examination (VIBE) sequence. Three experienced radiologists recorded the presence of erosions, non-erosion bony defects, and the presence of JSpA, with confidence scoring for each, in 3 blinded re-randomized reading exercises: (1) T1-weighted spin-echo (T1) and short-tau inversion recovery (STIR) sequences only; (2) VIBE only; (3) all sequences. Discrepancies were resolved by consensus read-out. The reference standard was rheumatologist diagnosis of JSpA. RESULTS: MRI was considered indicative of JSpA in 14 cases (16.7%) on T1/STIR, 21 (25.0%) on VIBE only, and 15 (17.9%) with all sequences. In the three exercises, erosions were scored in 12 (14.3%), 22 (26.2%), and 13 (15.5%) cases, and non-erosion bony defects in 43 (51.2%), 79 (94.0%), and 80 (95.2%) cases. Sensitivity/specificity for JSpA diagnosis was 34.6/91.4%, 42.3/82.8%, and 38.5/91.4%, after consensus read-out 38.5/94.8%. Mean absolute values of confidence scores significantly improved for all features after adding VIBE, although inter-reader agreement did not consistently improve. CONCLUSION: Adding VIBE to T1/STIR significantly increased reader confidence in JSpA diagnosis. However, a trend toward improved sensitivity and specificity was not statistically significant. If the ASAS-SPARTAN SIJ MRI protocol is applied to children, all sequences must be interpreted together to avoid mistaking non-erosion defects for true erosions. KEY POINTS: Question Can the recently published ASAS-SPARTAN adult standardized image acquisition protocol for sacroiliac joint MRI be used for diagnostic evaluation of sacroiliitis in children suspected for Juvenile Spondyloarthropathy (JSpA)? Findings The ASAS/SPARTAN recommendations including a high-resolution 3D erosion-sensitive sequence can also be applied to children, resulting in significantly increased reader confidence, with a trend toward improved sensitivity/specificity for diagnosing JSpA, although not statistically significant. Clinical relevance The ASAS-SPARTAN adult sacroiliac joint MRI protocol can also be beneficially applied to children, as long as all sequences are interpreted together to avoid mistaking non-erosion defects (almost universally seen on the 3D erosion-sensitive sequences in children) for true erosions. CI - (c) 2026. The Author(s). FAU - Herregods, Nele AU - Herregods N AUID- ORCID: 0000-0003-0244-0168 AD - Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium. Nele.Herregods@uzgent.be. FAU - Lambert, Robert G W AU - Lambert RGW AD - Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. AD - Medical Imaging Consultants, Edmonton, Alberta, Canada. FAU - Wichuk, Stephanie AU - Wichuk S AD - Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. AD - Medical Imaging Consultants, Edmonton, Alberta, Canada. FAU - Schiettecatte, Eva AU - Schiettecatte E AD - Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium. FAU - Renson, Thomas AU - Renson T AD - Department of Pediatric Rheumatology, Ghent University Hospital, Ghent, Belgium. FAU - Dehoorne, Joke AU - Dehoorne J AD - Department of Pediatric Rheumatology, Ghent University Hospital, Ghent, Belgium. FAU - Jans, Lennart B O AU - Jans LBO AD - Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium. FAU - Jaremko, Jacob L AU - Jaremko JL AD - Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. AD - Medical Imaging Consultants, Edmonton, Alberta, Canada. LA - eng PT - Journal Article DEP - 20260627 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 SB - IM MH - Humans MH - Female MH - *Magnetic Resonance Imaging/methods MH - *Sacroiliac Joint/diagnostic imaging/pathology MH - Adolescent MH - *Imaging, Three-Dimensional/methods MH - Child MH - Male MH - Prospective Studies MH - Sensitivity and Specificity MH - Reproducibility of Results MH - Arthritis, Juvenile/diagnostic imaging PMC - PMC13661692 OTO - NOTNLM OT - Imaging, three-dimensional-sacroiliac joints OT - Juvenile idiopathic arthritis OT - Sacroiliitis OT - Spondyloarthropathies COIS- Compliance with ethical standards. Guarantor: The scientific guarantor of this publication is Nele Herregods. Conflict of interest: The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. Statistics and biometry: One of the authors (Stephanie Wichuk) has significant statistical expertise. Informed consent: Written informed consent was obtained from all patients in this study and from their parents. Ethical approval: This prospective study was approved by the Ghent University Hospital Ethics Committee. Study subjects or cohorts overlap: None. Methodology: Prospective Diagnostic Observational Performed at one institution EDAT- 2026/06/27 04:10 MHDA- 2026/10/13 23:35 PMCR- 2026/06/27 CRDT- 2026/06/26 23:22 PHST- 2025/12/12 00:00 [received] PHST- 2026/06/07 00:00 [accepted] PHST- 2026/05/08 00:00 [revised] PHST- 2026/10/13 23:35 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:22 [entrez] PHST- 2026/06/27 00:00 [pmc-release] AID - 10.1007/s00330-026-12709-y [pii] AID - 12709 [pii] AID - 10.1007/s00330-026-12709-y [doi] PST - ppublish SO - Eur Radiol. 2026 Nov;36(11):8062-8071. doi: 10.1007/s00330-026-12709-y. Epub 2026 Jun 27. PMID- 42362717 OWN - NLM STAT- Publisher LR - 20260626 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) DP - 2026 Jun 26 TI - Prevalence and biopsychosocial factors associated with overweight and obesity in adults with type 1 diabetes. LID - 10.1038/s41366-026-02147-7 [doi] AB - BACKGROUND: To describe the prevalence of overweight and obesity in adults living with type 1 diabetes and examine the association between biopsychosocial factors according to weight status. METHODS: A single-center, cross-sectional study was conducted in adults with type 1 diabetes attending a tertiary hospital between 2018 and 2020. Participants completed an online survey with validated questionnaires to assess physical activity; measure anxiety and depression; evaluate the perception of health-related quality of life [Spanish version of Diabetes Quality of Life Questionnaire (EsDQoL)], assess eating disorders [Spanish version of Diabetes Eating Problem Survey (EPAD-R)] and measure neuroticism. Sociodemographic data and information from the last outpatient visit regarding diabetes history, long-term complications, current insulin therapy, anthropometric measurements and laboratory data were also included. RESULTS: Data from 459 surveys were available for analysis. Participants had a mean (SD) of age of 44.7 (14.0) years; 55.6% were women; BMI 26.0 (4.7) kg/m(2) and the HbA(1c) was 7.57%. The prevalence of overweight (BMI 25-29.9 kg/m(2)) and obesity (BMI > 30 kg/m(2)) was 38.8% and 14.8%, respectively, with 10.6% being class I (30-34.9 kg/m(2)), 2.2% class II (35-39.9 kg/m(2)) and 2.0% class III (>40 kg/m(2)). Older age, living with a child/children, a higher EPAD-R score, a higher total insulin doses, receiving lipid-lowering therapy, and a higher EsDQoL score in the diabetes-related worries dimension were associated with a greater likelihood of living with obesity. CONCLUSIONS: Overweight and obesity are highly prevalent among adults living with type 1 diabetes, and the identified biopsychosocial factors reveals how excess weight arises from complex interactions among demographic, clinical, and psychological influences. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Tundidor, Diana AU - Tundidor D AUID- ORCID: 0000-0002-8629-9706 AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. FAU - Blanco, Jesus AU - Blanco J AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Canizares, Silvia AU - Canizares S AD - Clinical Psychology and Psychobiology Department, Section of Clinical Health Psychology, Clinical Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Segui, Nuria AU - Segui N AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Obach, Amadeu AU - Obach A AD - Clinical Psychology and Psychobiology Department, Section of Clinical Health Psychology, Clinical Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Molero, Judith AU - Molero J AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Conget, Ignacio AU - Conget I AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Gimenez, Marga AU - Gimenez M AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Vidal, Josep AU - Vidal J AUID- ORCID: 0000-0002-4564-4518 AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Flores, Lilliam AU - Flores L AUID- ORCID: 0000-0001-5765-8813 AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. lflores@clinic.cat. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. lflores@clinic.cat. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. lflores@clinic.cat. LA - eng PT - Journal Article DEP - 20260626 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/06/27 00:53 MHDA- 2026/06/27 00:53 CRDT- 2026/06/26 23:20 PHST- 2025/04/14 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/27 00:53 [medline] PHST- 2026/06/27 00:53 [pubmed] PHST- 2026/06/26 23:20 [entrez] AID - 10.1038/s41366-026-02147-7 [pii] AID - 10.1038/s41366-026-02147-7 [doi] PST - aheadofprint SO - Int J Obes (Lond). 2026 Jun 26. doi: 10.1038/s41366-026-02147-7. PMID- 42362716 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261011 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 9 DP - 2026 Sep TI - Reassessing BMI thresholds for obesity: a population-based study in Turkish adults. PG - 1988-1994 LID - 10.1038/s41366-026-02142-y [doi] AB - BACKGROUND: The global prevalence of obesity has been steadily increasing, posing major public health challenges. Current universal BMI cut-off points may not accurately reflect obesity risk across different ethnicities, including the Turkish population. OBJECTIVE: This study aimed to evaluate the relationship between body mass index (BMI) and body fat percentage (BF%) and determine appropriate BMI cut-off points for diagnosing obesity in Turkish adults. METHODS: A cross-sectional study was conducted among Turkish individuals aged 18-65 in four major districts of Kayseri. Anthropometric measurements were obtained, including height, weight, waist circumference, and hip circumference. Body composition was assessed using bioelectrical impedance analysis (BIA). ROC (Receiver Operating Characteristic) curve analysis was performed to identify optimal BMI cut-off points for predicting obesity based on BF%. Pearson correlation analysis evaluated the relationship between BMI and BF%. RESULTS: The participants had a mean age of 39.9 +/- 13.3 years, and 51.6% were female. A strong positive correlation between BMI and BF% was found for both women (r = 0.86, p < 0.001) and men (r = 0.68, p < 0.001). The optimal BMI cut-off point for detecting obesity was 28.76 kg/m(2) for the total sample, 28.80 kg/m(2) for women, and 28.76 kg/m(2) for men. Using these new thresholds, the obesity prevalence increased from 27.7% to 33.6%. The AUC values indicated excellent discriminative power for women (AUC = 0.98) and good discriminative power for men (AUC = 0.91). CONCLUSION: The current universal BMI cut-off points (>/=30 kg/m(2)) may underestimate obesity prevalence in the Turkish population. Establishing national and gender-specific BMI thresholds could improve the accuracy of obesity diagnosis and support more effective public health interventions targeting chronic non-communicable diseases. CI - (c) 2026. The Author(s). FAU - Zeynep Ozsaydi, Semiha AU - Zeynep Ozsaydi S AUID- ORCID: 0000-0003-0065-9633 AD - Health Directorate of Kayseri, Kayseri, Turkey. FAU - Durmus, Hasan AU - Durmus H AUID- ORCID: 0000-0001-5719-1475 AD - Department of Public Health, School of Medicine, Erciyes University, Kayseri, Turkey. hasandurmus@erciyes.edu.tr. FAU - Tekdemir, Leyla AU - Tekdemir L AUID- ORCID: 0000-0002-5130-4237 AD - Health Directorate of Kayseri, Kayseri, Turkey. FAU - Ozsaydi, Seckin AU - Ozsaydi S AUID- ORCID: 0000-0001-8350-288X AD - Health Directorate of Kayseri, Kayseri, Turkey. FAU - Borlu, Arda AU - Borlu A AUID- ORCID: 0000-0002-1424-8037 AD - Department of Public Health, School of Medicine, Erciyes University, Kayseri, Turkey. FAU - Oner, Neslihan AU - Oner N AUID- ORCID: 0000-0001-6773-4963 AD - Erciyes University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Kayseri, Turkey. LA - eng PT - Journal Article DEP - 20260626 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - *Body Mass Index MH - Female MH - Turkey/epidemiology MH - Male MH - Adult MH - *Obesity/epidemiology/diagnosis MH - Cross-Sectional Studies MH - Middle Aged MH - Prevalence MH - Body Composition MH - Adolescent MH - Young Adult MH - ROC Curve MH - Electric Impedance MH - Aged MH - Waist Circumference MH - Reference Values PMC - PMC13649583 COIS- Competing interests: The authors declare no competing interests. Ethical approval: Ethical approval for this study was obtained from the Erciyes University Clinical Research Ethics Committee (Approval No: 2024/212). All methods were performed in accordance with the relevant guidelines and regulations (e.g., Declaration of Helsinki). Informed consent: Informed consent was obtained from all subjects involved in the study. Written informed consent was obtained from all participants prior to their participation in the study. EDAT- 2026/06/27 04:10 MHDA- 2026/10/09 05:30 PMCR- 2026/06/26 CRDT- 2026/06/26 23:20 PHST- 2025/04/29 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/05/13 00:00 [revised] PHST- 2026/10/09 05:30 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:20 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.1038/s41366-026-02142-y [pii] AID - 2142 [pii] AID - 10.1038/s41366-026-02142-y [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Sep;50(9):1988-1994. doi: 10.1038/s41366-026-02142-y. Epub 2026 Jun 26. PMID- 42362698 OWN - NLM STAT- Publisher LR - 20260904 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 26 TI - 20/ (fasting C-peptide x fasting plasma glucose) as a novel marker for insulin resistance in obese children and adolescents. LID - 10.1038/s41390-026-05251-6 [doi] AB - BACKGROUND: Insulin resistance (IR) constitutes a critical pathophysiological mechanism linking pediatric obesity to type 2 diabetes mellitus (T2DM) and cardiovascular disease. Recent investigations in adult populations have proposed 20/ fasting C-peptide x fasting plasma glucose (20/ (Fcpep X FBG)) as a good biomarker for IR. We aimed to evaluate the diagnostic utility of this novel index in detecting IR among obese pediatric patients. METHODS: This case-control study included 100 children (50 obese and 50 controls), aged 6-16 years. Anthropometric, clinical, and laboratory assessments were performed, including fasting blood glucose, fasting serum insulin, fasting C-peptide, and lipid profile. IR was evaluated using HOMA-IR, HbA1c, TyG index, and 20/ (Fcpep X FBG). RESULTS: Obese children demonstrated significantly elevated metabolic parameters, including body mass index (BMI), HOMA-IR, and fasting C-peptide. The (20/Fcpep x FBG) index was significantly lower in obese subjects (0.10 +/- 0.04 vs. 0.18 +/- 0.05, p < 0.001) and exhibited strong inverse correlations with HOMA-IR, BMI, TyG index, and HbA1c. 20/ Fcpep X FBG can significantly predict IR at a cut-off 1.25 mL kg(-1)) and 29 (5.91%) showed high-risk gastric antrum morphology. Spearman correlation analysis demonstrated no significant association between prolonged fasting duration and GRV/WT (rho = 0.037, 95% CI: - 0.054 to 0.128, p = 0.41). GRV/WT correlated positively with age and negatively with body mass index. These findings suggest that prolonged preoperative fasting does not independently associate with GRV in pediatric patients. CI - (c) 2026. The Author(s). FAU - Wu, Qingda AU - Wu Q AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Liu, Bin AU - Liu B AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. AD - Department of Anesthesiology, Heyou Hospital, Foshan, China. FAU - Wang, Zhouwu AU - Wang Z AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Chen, Lingzhi AU - Chen L AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Liu, Hao AU - Liu H AD - Department of Anesthesiology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Zou, Qi AU - Zou Q AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Zhao, Yongzhen AU - Zhao Y AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Ding, Zhenhao AU - Ding Z AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Chen, Lu AU - Chen L AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. chenlu200505399@163.com. FAU - Zheng, Zhenwei AU - Zheng Z AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. wind_8228@163.com. LA - eng GR - No.72 [2024] - 159/Shantou Medical Health Science and Technology Project (CN)/ PT - Journal Article DEP - 20260626 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Fasting OT - Gastric residual volume OT - Gastric ultrasonography OT - Pediatric COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Institutional Review Board approval was obtained. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:10 CRDT- 2026/06/26 23:18 PHST- 2026/03/10 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:18 [entrez] AID - 10.1038/s41598-026-57602-2 [pii] AID - 10.1038/s41598-026-57602-2 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-57602-2. PMID- 42362607 OWN - NLM STAT- Publisher LR - 20260626 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jun 26 TI - The impact of exposure to fluoride in drinking water on intelligence in school age children in Iran. LID - 10.1038/s41598-026-56923-6 [doi] AB - The present study aimed to compare the intelligence quotient (IQ) and body mass index (BMI) of 161 school-aged children (10-12 years old) residing in two cities with different levels of fluoride (F(-)) in drinking-water: 0.02 mg/L in Lalehzar (City 1) and 1.15 mg/L, corresponding to the WHO guideline value, in Reyhanshahr (City 2), Kerman Province, southeastern Iran. Additionally, the study evaluated, for the first time in 2024, the associated non-carcinogenic health risk and investigated the potential role of aluminum (Al) in forming F-Al complexes that may cross the blood-brain barrier. IQ scores were assessed using Raven's Standard Progressive Matrices, and water samples were analyzed for aluminum and fluoride content. The mean aluminum concentrations were 0.01 mg/L in City 1 and 0.04 mg/L in City 2 (p < 0.001). The corresponding mean IQ scores were 108.55 +/- 11.50 and 110.41 +/- 9.53, respectively, showing no statistically significant difference (p = 0.264). Regression analysis revealed no significant association between Al concentration in drinking-water and IQ (p = 0.279). A significant inverse relationship was observed between fluoride concentration and BMI (p = 0.01). Due to the conflicting findings regarding whether fluoride is safe for children's intelligence within the WHO limits, it is not possible to make a definitive statement. However, an increase in fluoride concentration appeared to be associated with a reduction in BMI, likely due to fluoride's influence on growth parameters, particularly height development. Hazard quotient (HQ) values were below unity in both cities, indicating no potential risk associated with fluoride exposure. Although the estimated risk level in City 2 was below the safety threshold (HQ = 0.81), it was relatively close to unity, warranting attention. Therefore, it is recommended that local authorities monitor and, if feasible, reduce fluoride concentrations in drinking-water, limiting additional exposure to fluoride-containing products such as toothpaste and mouthwash. Longitudinal studies in broader age groups are needed to confirm these associations and clarify the underlying mechanisms. CI - (c) 2026. The Author(s). FAU - Rezaei, Mahdi AU - Rezaei M AUID- ORCID: 0000-0002-6939-1455 AD - Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran. AD - Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran. FAU - Karamoozian, Ali AU - Karamoozian A AUID- ORCID: 0000-0002-1677-2852 AD - Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. AD - Department of Biostatistics and Epidemiology, Kerman University of Medical Sciences, Kerman, Iran. FAU - Faraji, Maryam AU - Faraji M AUID- ORCID: 0000-0002-7220-4438 AD - Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran. m.faraji@kmu.ac.ir. AD - Department of Environmental Health Engineering, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran. m.faraji@kmu.ac.ir. LA - eng GR - 402001053/Environmental Health Engineering Research Center/ PT - Journal Article DEP - 20260626 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Body mass index OT - Children OT - Drinking-water OT - Fluoride OT - Intelligence quotient OT - Risk assessment COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: The current study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of "Kerman University of Medical Sciences" (Date: 20th May 2024 / No: IR.KMU.REC.1403.081). Consent to participate: Since the participants in the current study were under 18 years old (students aged 10-12), written informed consent was obtained from their parents. Consent to publish: The authors affirm that research participants' parents provided informed consent for using their studied data (parents' occupation and educational levels, family income, etc.), and their children's characteristics (height, weight, IQ score, BMI, etc.) anonymously in the current study and also for publishing. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:10 CRDT- 2026/06/26 23:17 PHST- 2025/02/17 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:17 [entrez] AID - 10.1038/s41598-026-56923-6 [pii] AID - 10.1038/s41598-026-56923-6 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-56923-6. PMID- 42362166 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260822 IS - 1873-6513 (Electronic) IS - 0885-3924 (Linking) VI - 72 IP - 4 DP - 2026 Oct TI - Perceived Stigma, Psychological Distress, and Symptom Burden in Decompensated Cirrhosis. PG - 457-466.e2 LID - S0885-3924(26)00860-2 [pii] LID - 10.1016/j.jpainsymman.2026.06.021 [doi] AB - CONTEXT: Despite perceived stigma's impact in HIV, mental illness, and obesity, its association with adverse outcomes in decompensated cirrhosis (DC) remains under-investigated. OBJECTIVES: We aimed to quantify liver-related perceived stigma and examine its associations with patient-reported psychological distress and symptom burden among patients with DC. METHODS: We conducted a cross-sectional study of outpatients with DC from August 2018 to September 2022. Participants completed validated instruments: the four-item perceived stigma domain from the Short-Form Liver Disease Quality of Life questionnaire (range 0-100; reverse-scored where higher scores = greater stigma), the Hospital Anxiety and Depression Scale (0-21; scores >/=8: clinically significant anxiety and depression symptoms), and the Revised Edmonton Symptom Assessment System (0-100; scores >/=40: moderate-to-severe burden). We used multivariable linear regression adjusted for age, gender, etiology, and DC severity. RESULTS: Among 218/312 (70%) eligible patients (median age 60 [interquartile range 51-65]; 54% male; 58% alcohol-related; median MELD-Na 16), mean stigma score was 34.3 (standard deviation 26.3). Greater stigma was reported by those with advanced disease (Child-Pugh A vs. B vs. C: 19.4 vs. 32.2 vs. 42.2; P = 0.001) and younger patients (18-44 vs. 45-64 vs. >/=65: 38.6 vs. 37.1 vs. 26.2; P = 0.019). In adjusted analyses, greater stigma was independently associated with higher depression symptoms (beta = 0.08, P < 0.001), anxiety symptoms (beta = 0.07, P < 0.001), and symptom burden (beta = 0.33, P < 0.001). CONCLUSIONS: Among patients with DC, younger adults and those with advanced disease reported greater perceived stigma, independently associated with higher psychological distress and symptom burden. These findings highlight perceived stigma as a modifiable target for palliative care-focused interventions to improve patient-reported outcomes in DC. CI - Copyright (c) 2026 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved. FAU - Bromfield, Brittany AU - Bromfield B AD - Department of Gastroenterology and Hepatology (B.B.), Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Zeng, Chengbo AU - Zeng C AD - Patient Reported Outcomes, Values, and Experience (PROVE) Center (C.Z.), Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Ojeaburu, Leslie AU - Ojeaburu L AD - Department of Medicine (L.O.), Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Mason, Nancy AU - Mason N AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Engel, Kirsten G AU - Engel KG AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Rowland, Michaela AU - Rowland M AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Kenimer, Sara AU - Kenimer S AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - O'Brien, Karen AU - O'Brien K AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Diop, Michelle S AU - Diop MS AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Donlan, John AU - Donlan J AD - Department of Internal Medicine (J.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Indriolo, Teresa AU - Indriolo T AD - Division of Pain Medicine (T.I.), Stanford University School of Medicine, Palo Alto, California, USA. FAU - Li, Lucinda AU - Li L AD - Department of Medicine, David Geffen School of Medicine at UCLA (L.L.), Los Angeles, California, USA. FAU - Zhu, Enya AU - Zhu E AD - Department of Medicine, Duke University School of Medicine (E.Z.), Durham, North Carolina, USA. FAU - Armstrong, Malia E AU - Armstrong ME AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Bizup, Grace AU - Bizup G AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Munroe, Will AU - Munroe W AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Dalvi, Anushka AU - Dalvi A AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Li, Xing AU - Li X AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Lau-Min, Kelsey S AU - Lau-Min KS AD - Division of Hematology and Oncology (K.S.L., A.E.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Brown, Cristal AU - Brown C AD - Department of Internal Medicine (C.B.), University of Texas at Austin Dell Medical School, Austin, Texas, USA. FAU - Zhang, Wei AU - Zhang W AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - El-Jawahri, Areej AU - El-Jawahri A AD - Division of Hematology and Oncology (K.S.L., A.E.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Ufere, Nneka N AU - Ufere NN AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address: nneka.ufere@mgh.harvard.edu. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - J Pain Symptom Manage JT - Journal of pain and symptom management JID - 8605836 SB - IM MH - Humans MH - Male MH - Female MH - Symptom Burden MH - *Liver Cirrhosis/psychology MH - Cross-Sectional Studies MH - Middle Aged MH - Aged MH - *Psychological Distress MH - *Social Stigma MH - Quality of Life MH - Depression MH - Anxiety MH - Severity of Illness Index OTO - NOTNLM OT - Decompensated cirrhosis OT - anxiety OT - depression OT - patient-reported outcomes OT - stigma OT - symptom burden EDAT- 2026/06/27 00:52 MHDA- 2026/08/22 23:43 CRDT- 2026/06/26 19:35 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/17 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/06/27 00:52 [pubmed] PHST- 2026/06/26 19:35 [entrez] AID - S0885-3924(26)00860-2 [pii] AID - 10.1016/j.jpainsymman.2026.06.021 [doi] PST - ppublish SO - J Pain Symptom Manage. 2026 Oct;72(4):457-466.e2. doi: 10.1016/j.jpainsymman.2026.06.021. Epub 2026 Jun 26. PMID- 42361874 OWN - NLM STAT- MEDLINE DCOM- 20260809 LR - 20260831 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 306 IP - Pt 1 DP - 2026 Sep 15 TI - Effects of a walk in a residential natural vs. urban environment on objective and subjective stress indicators in mothers and their infants. PG - 125125 LID - S0013-9351(26)01456-8 [pii] LID - 10.1016/j.envres.2026.125125 [doi] AB - Despite growing evidence that being in nature positively influences mood and stress, its effects on children are not well understood. Previous cross-sectional research suggests that greater green space in children's residential environments is associated with better mental health outcomes, but the causal relationship remains unclear. Moreover, the impact of such environments on infants has not yet been explored. To address these gaps, we conducted an experimental intervention study with 72 mother-infant dyads (mean infant age = 7.5 months) to examine the effects of natural vs. urban environments on their stress. To enhance ecological validity, the study took place in residential, everyday environments, and the walks were conducted independently of the experimenter team. The study employed a randomised crossover trial, in which each mother-infant pair completed two 45-min walks, one in a natural setting and one in an urban area. We assessed subjective and physiological stress indicators, including maternal self-reported stress, salivary cortisol in mothers and infants, and cortisol levels in mothers' breast milk. The results showed that mothers' subjective stress levels decreased after both walks (p = 0.001), accompanied by a reduction in arousal (p < 0.001). Additionally, salivary cortisol concentrations decreased after walks in both environments for mothers (p = 0.007) and infants (p = 0.007). Mothers further reported increased calmness (p = 0.001), greater pleasantness (p = 0.002), and improved mood (p < 0.001) after the both walks, while also rating the nature walk as more enjoyable (p < 0.001) and more attention-restorative (p < 0.001) than the urban walk. However, the type of environment did not significantly affect subjective or physiological stress levels in mothers and infants. These findings suggest that taking a walk outdoors was associated with reduced stress in mothers and infants, but that the environment may play less of a role in this effect. The results underscore the complex relationship between environmental exposure and stress, offering insights for future research into how different environments influence early-life stress regulation. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Sudimac, Sonja AU - Sudimac S AD - Max Planck Institute for Human Development, Center for Environmental Neuroscience, Lentzeallee 94, Berlin, 14195, Germany. Electronic address: sudimac@mpib-berlin.mpg.de. FAU - Drewelies, Johanna AU - Drewelies J AD - Max Planck Institute for Human Development, Center for Environmental Neuroscience, Lentzeallee 94, Berlin, 14195, Germany. FAU - de Weerth, Carolina AU - de Weerth C AD - Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Kapittelweg 29, Nijmegen, 6525 GD, the Netherlands. FAU - Kuhn, Simone AU - Kuhn S AD - Max Planck Institute for Human Development, Center for Environmental Neuroscience, Lentzeallee 94, Berlin, 14195, Germany; University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Martinistr. 52, Hamburg, 20251, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research Berlin, Germany and London, UK, Lentzeallee 94, Berlin, 14195, Germany; Psychiatric Environmental Neuroscience (PEN), Clinic for Psychiatry CCM, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Bonhoefferweg 3, Berlin, 10117, Germany. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260626 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Humans MH - Female MH - *Walking MH - Infant MH - *Mothers/psychology MH - Hydrocortisone/analysis MH - Adult MH - Subjective Stress MH - *Stress, Psychological MH - Saliva/chemistry MH - Cross-Over Studies MH - Milk, Human/chemistry MH - Urban Population MH - Male MH - Stress, Physiological OTO - NOTNLM OT - Cortisol OT - Environment OT - Infants OT - Natural OT - Stress OT - Urban OT - Walk COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/27 00:53 MHDA- 2026/08/10 00:40 CRDT- 2026/06/26 19:31 PHST- 2025/11/30 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/08/10 00:40 [medline] PHST- 2026/06/27 00:53 [pubmed] PHST- 2026/06/26 19:31 [entrez] AID - S0013-9351(26)01456-8 [pii] AID - 10.1016/j.envres.2026.125125 [doi] PST - ppublish SO - Environ Res. 2026 Sep 15;306(Pt 1):125125. doi: 10.1016/j.envres.2026.125125. Epub 2026 Jun 26. PMID- 42361335 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Jun 26 TI - Codevelopment of a Digital Screening and Intervention Tool to Improve Lifestyle Habits in Children: Focus Group Study With Parents and Clinicians. PG - e84304 LID - 10.2196/84304 [doi] LID - e84304 AB - BACKGROUND: Chronic preventable diseases represent a major burden in Canada, often rooted in unhealthy behaviors established during childhood. Despite recommendations for routine screening, most children are not assessed due to clinical barriers. This paper presents the early development of Project DISCO, a self-administered, digital preappointment tool to screen for and support healthy lifestyle behaviors, including physical activity, sleep, nutrition, and screen time, in children aged 2 to 12 years. OBJECTIVE: This study aimed to explore clinicians' and parents' needs and past experiences with health technology; integrate their insights into the development of a digital tool for promoting health behaviors; and evaluate the usability, relevance, and acceptability of this tool. METHODS: Three semistructured focus group and interview sessions were conducted with primary care clinicians and parents. Participants were recruited at the Groupe de Medecine de Famille Universitaire Saint-Hubert using purposive and convenience sampling: clinicians were recruited internally, whereas parents of children aged 2 to 12 years were invited via emails sent by clinic staff. Data were analyzed using a combination of inductive and deductive approaches. Findings informed iterative refinements throughout the codevelopment of the digital tool for promoting healthy lifestyle behaviors in children. RESULTS: A total of 8 participants took part in 6 discussions, including 5 parents of children aged 3 to 12 years and 3 primary care clinicians. Hybrid thematic analysis identified six themes: (1) the potential of a digital tool to promote healthy habits in pediatrics; (2) implementation challenges and opportunities, including integration of the tool into clinical workflow; (3) adherence to and engagement with the tool, with suggestions for reminders and involvement of nurses; (4) perceived limitations and improvement of the screening tool, particularly the nutrition and sleep questionnaires; (5) feedback on the screening report and intervention emphasizing clarity and actionable guidance; and (6) perceived clinical value and opportunity costs. Insights from these discussions guided refinements of the digital tool. CONCLUSIONS: The findings support the tool's relevance and inform its ongoing development. A feasibility study is planned prior to a randomized controlled trial. CI - (c)Alice Moyne, Tamara Perez, Trevor van Mierlo, Maryam Kebbe, Olivier Drouin. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org), 26.06.2026. FAU - Moyne, Alice AU - Moyne A AUID- ORCID: 0009-0008-0239-5954 AD - Department of Nutrition, Universite de Montreal, Montreal, QC, Canada. AD - Centre de recherche Azrieli du Centre Hospitalier Universitaire Sainte-Justine, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada. AD - Departement Prevention Cancer Environnement, Centre Leon Berard, Lyon, Auvergne-Rhone-Alpes, France. FAU - Perez, Tamara AU - Perez T AUID- ORCID: 0000-0002-9892-3043 AD - Centre de recherche Azrieli du Centre Hospitalier Universitaire Sainte-Justine, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada. FAU - van Mierlo, Trevor AU - van Mierlo T AUID- ORCID: 0000-0002-5675-0084 AD - Evolution Health, Toronto, ON, Canada. FAU - Kebbe, Maryam AU - Kebbe M AUID- ORCID: 0000-0001-7999-9299 AD - Faculty of Kinesiology, University of New Brunswick, Fredericton, NB, Canada. FAU - Drouin, Olivier AU - Drouin O AUID- ORCID: 0000-0003-1429-9341 AD - Department of Nutrition, Universite de Montreal, Montreal, QC, Canada. AD - Centre de recherche Azrieli du Centre Hospitalier Universitaire Sainte-Justine, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada. AD - Department of Pediatrics, Universite de Montreal, Montreal, QC, Canada. AD - Department of Pediatrics, Division of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada. AD - Department of Social and Preventive Medicine, School of Public Health, Universite de Montreal, Montreal, QC, Canada. LA - eng PT - Journal Article DEP - 20260626 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13354948 OTO - NOTNLM OT - digital tool OT - intervention OT - lifestyle behavior OT - pediatrics OT - qualitative study OT - screening COIS- Conflicts of Interest: None declared. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:11 PMCR- 2026/06/26 CRDT- 2026/06/26 16:53 PHST- 2025/09/17 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/04/16 00:00 [revised] PHST- 2026/06/27 04:11 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 16:53 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - v9i1e84304 [pii] AID - 10.2196/84304 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Jun 26;9:e84304. doi: 10.2196/84304. PMID- 42361330 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jun 26 TI - Digital Interventions Targeting Parents to Improve Early Childhood Movement, Nutrition, and Sleep Behaviors: Systematic Review. PG - e85525 LID - 10.2196/85525 [doi] LID - e85525 AB - BACKGROUND: Early childhood (0-5 years) is key for shaping health behaviors, yet optimal behaviors are rarely achieved. Digital health promotion interventions offer scalable support for families; however, most research has focused on childhood more broadly, leaving limited evidence for the early childhood period. OBJECTIVE: The primary aim of this systematic review was to examine whether autonomously delivered digital interventions targeting parents are effective at increasing physical activity, reducing sedentary behavior, improving nutrition (breastfeeding, feeding practices), and/or optimizing sleep among children aged 0-5 years. The secondary aim was to review the reporting of co-design practices, user engagement, and process evaluation, and to assess how engagement influences intervention effectiveness. METHODS: Seven databases were searched for randomized controlled trials (RCTs) evaluating autonomously delivered digital interventions targeting one or more of the following behaviors: physical activity, sedentary behavior, nutrition, or sleep among children (published to January 2026). Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for RCTs. Findings were narratively synthesized by target age-group and behavior, and the direction of effect was summarized in structured tables. RESULTS: Of the 14,352 identified records, 38 interventions (33 RCTs, 4 pilot RCTs, and 1 feasibility RCT) were included. Most studies focused on pregnancy to infancy (n=24; 0-1 y), followed by preschoolers (n=8; 3-5 y) and toddlers (n=6; 1-2 y). Intervention duration ranged from 2 weeks to 1000 days, and various digital formats were used (apps n=11, SMS text messaging n=10, web- or internet-based platforms n=6, WeChat [Tencent] n=3, tablet-based program n=2, a combination of app and SMS text messaging n=1, website and emails n=1, emails and SMS text messaging n=1, automated voice calls n=1, Facebook Messenger Chatbot [Meta] n=1, and online videos n=1). Interventions spanning pregnancy to infancy reported mixed findings for breastfeeding and feeding practices. Studies targeting toddlers showed improvements in sleep, mixed findings for diet and screen time, and no differences in physical activity. Most studies targeting preschoolers reported significant improvements for feeding practices and diet, but no differences in physical activity, sedentary behavior and sleep, and mixed findings for screen time. Most studies reported co-design or engagement (n=24), but few examined the impact of engagement on intervention effectiveness (n=6), and those that did reported mixed findings. Interpretation was limited by heterogeneous designs, inconsistent outcome measures, and mixed risk-of-bias ratings across studies. CONCLUSIONS: This review advances the field by synthesizing evidence on scalable digital interventions that support parents in promoting healthy lifestyle behaviors across the first 2000 days, together with key design and implementation factors that have rarely been reported in previous reviews. Unlike prior work, it focuses exclusively on autonomously delivered digital interventions in early childhood. Findings show heterogeneous designs and mixed effectiveness, and highlight 3 priority evidence gaps: limited studies in toddlers and preschoolers, incomplete reporting of engagement, and limited understanding of how engagement influences outcomes. These findings define priorities for future research to strengthen the evidence for scalable digital interventions in early childhood. CI - (c) Johanna Sandborg, Brittany L Reese, Sarah Marshall, Kylie D Hesketh, Rachel Laws, Katherine L Downing. Originally published in the Journal of Medical Internet Research (https://www.jmir.org). FAU - Sandborg, Johanna AU - Sandborg J AUID- ORCID: 0000-0003-0389-9333 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. FAU - Reese, Brittany L AU - Reese BL AUID- ORCID: 0000-0001-6242-0842 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. FAU - Marshall, Sarah AU - Marshall S AUID- ORCID: 0000-0002-1462-3087 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. AD - Sydney School of Public Health, The University of Sydney, Sydney, Australia. FAU - Hesketh, Kylie D AU - Hesketh KD AUID- ORCID: 0000-0002-2702-7110 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. FAU - Laws, Rachel AU - Laws R AUID- ORCID: 0000-0003-4328-1116 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. FAU - Downing, Katherine L AU - Downing KL AUID- ORCID: 0000-0002-6552-8506 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260626 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - *Sleep MH - Child, Preschool MH - *Parents MH - Infant MH - Female MH - *Exercise MH - *Health Promotion/methods MH - Digital Health MH - Digital Media MH - Infant, Newborn MH - Sedentary Behavior MH - Breast Feeding MH - *Health Behavior MH - *Nutritional Status MH - Randomized Controlled Trials as Topic PMC - PMC13309061 OTO - NOTNLM OT - breastfeeding OT - diet OT - digital OT - eHealth OT - mHealth OT - movement behaviours OT - physical activity OT - screen time OT - sedentary behaviour COIS- Conflicts of Interest: JS is a founder of Science4Families AB, but this company had no role in this research. No other disclosures were reported. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 18:37 PMCR- 2026/06/26 CRDT- 2026/06/26 16:52 PHST- 2025/10/08 00:00 [received] PHST- 2026/04/03 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/06/27 18:37 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 16:52 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - v28i1e85525 [pii] AID - 85525 [pii] AID - 10.2196/85525 [doi] PST - epublish SO - J Med Internet Res. 2026 Jun 26;28:e85525. doi: 10.2196/85525. PMID- 42359683 OWN - NLM STAT- Publisher LR - 20260626 IS - 1536-0911 (Electronic) IS - 1536-0903 (Linking) DP - 2026 Jun 26 TI - NICU Nurses' Attitudes Toward Adopting an Evidence-Based Practice Intervention to Improve Bone Mineralization in Preterm Infants. LID - 10.1097/ANC.0000000000001397 [doi] AB - BACKGROUND: Metabolic bone disease (MBD) is a disorder affecting bone mineralization that leads to short and long-term consequences. A daily exercise regimen consisting of passive range of motion (ROM) and gentle compression of upper and lower extremities shows promising results in improving bone mineralization in preterm infants. However, the lack of nursing literature suggests that nurses may underutilize these interventions. PURPOSE: This study examined Neonatal Intensive Care Unit (NICU) nurses' attitudes toward adopting passive ROM and gentle compression to improve bone mineralization in preterm infants and explored whether knowledge of MBD influences the implementation of these practices. METHODS: A quantitative, descriptive, cross-sectional survey of 238 NICU nurses was conducted. The Evidence-Based Practice Attitude Scale (EBPAS) assessed attitudes toward evidence-based interventions. Additional questions evaluated nurses' knowledge of MBD and their use of passive ROM and gentle compression in clinical practice. RESULTS: Results showed favorable attitudes toward evidence-based practice (EBPAS M = 2.92, SD = 0.565). In this sample, 23.1% of nurses reported routinely performing passive ROM, and 7.2% reported performing gentle compression of upper and lower extremities. The EBPAS demonstrated high reliability (alpha = 0.884) and strong convergent validity (r = 0.633). No significant differences were found by years of experience (P = .55) or certification (P = .39). Over half of respondents lacked knowledge about MBD etiology (53.4%) and prevention/treatment (59.7%). IMPLICATIONS FOR PRACTICE AND RESEARCH: Findings highlight a knowledge gap despite positive attitudes. Incorporating MBD education and exercise techniques into NICU training may help standardize these evidence-based interventions and improve outcomes for preterm infants. CI - Copyright (c) 2026 by The National Association of Neonatal Nurses. FAU - Melendez Vassall, Idamis AU - Melendez Vassall I AUID- ORCID: 0009-0006-3763-3508 AD - Author Affiliations: The Barbara H. Hagan School of Nursing & Health Sciences, Molloy University, Rockville Centre, New York (Melendez Vassall and Mannino); Northwell Health, North Shore University Hospital, Manhasset, New York (Melendez Vassall and Perveen); and Office of Research and Scholarship, Molloy University, Rockville Centre, New York, New York (Watters). FAU - Mannino, Jennifer Emilie AU - Mannino JE AUID- ORCID: 0000-0001-9238-2293 FAU - Watters, Pamela AU - Watters P FAU - Perveen, Shahana AU - Perveen S LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Adv Neonatal Care JT - Advances in neonatal care : official journal of the National Association of Neonatal Nurses JID - 101125644 SB - IM OTO - NOTNLM OT - bone mineralization OT - evidence-based practice attitudes scale (EBPAS) OT - gentle compression OT - metabolic bone disease OT - nurse attitude OT - premature infant OT - range of motion EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:10 CRDT- 2026/06/26 06:04 PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 06:04 [entrez] AID - 00149525-990000000-00284 [pii] AID - 10.1097/ANC.0000000000001397 [doi] PST - aheadofprint SO - Adv Neonatal Care. 2026 Jun 26. doi: 10.1097/ANC.0000000000001397. PMID- 42359254 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Obesity is associated with suppressed bone turnover: a systematic review and meta-analysis. PG - 1793838 LID - 10.3389/fphys.2026.1793838 [doi] LID - 1793838 AB - BACKGROUND: Obesity is an increasingly serious public health issue on a global scale. Although there is increasing research on the relationship between obesity and biochemical markers of bone turnover, this relationship is complex and unclear. We conducted a systematic review and meta-analysis aimed at comparing the concentrations of biochemical markers of bone turnover between individuals with obesity and those with normal-weight. METHOD: A systematic search was conducted using the PubMed, EMBASE, Web of Science, Cochrane Library, and EBSCO databases from database inception to December 15, 2025. Two researchers screened the literature according to the inclusion and exclusion criteria and extracted valid data for quality evaluation. RESULTS: The results ultimately included 14 articles with a total of 4612 subjects. Compared with normal-weight individuals, individuals with obesity showed no significant difference in alkaline phosphatase (ALP) levels. Procollagen type I N-terminal propeptide (PINP) levels were significantly reduced in individuals with obesity. Osteocalcin (OCN) levels were also decreased overall, but subgroup analysis showed that this reduction was significant in children and adolescents, whereas no significant difference was observed in adults. No significant difference was observed in C-terminal telopeptide of type I collagen (CTX-I) or N-terminal telopeptide of type I collagen (NTX) levels. CONCLUSION: This meta-analysis suggests that obesity is associated with suppressed bone turnover, mainly reflected by reduced levels of bone formation markers. PINP levels were significantly decreased in individuals with obesity, whereas the reduction in OCN appeared to be age-dependent, with significant suppression observed in children and adolescents but not in adults. However, the robustness of the bone resorption results is insufficient and requires further validation through additional studies. Further studies are needed to clarify the mechanisms by which obesity affects skeletal health and to identify potential targets for clinical intervention. CI - Copyright (c) 2026 Lin, Liu, Chen and Liu. FAU - Lin, Haiqi AU - Lin H AD - School of Physical Education and Sports Science, South China Normal University, Guangzhou, Guangdong, China. AD - College of Physical Education, South China University of Technology, Guangzhou, Guangdong, China. FAU - Liu, Xiaohua AU - Liu X AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Chen, Binglin AU - Chen B AD - The Second School of Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China. FAU - Liu, Chengyi AU - Liu C AD - School of Physical Education and Sports Science, South China Normal University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article PT - Review DEP - 20260610 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13290598 OTO - NOTNLM OT - bone OT - bone formation OT - bone resorption OT - bone turnover (markers) OT - obesity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/26 06:39 PMCR- 2026/06/10 CRDT- 2026/06/26 04:45 PHST- 2026/01/22 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/26 06:39 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 04:45 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.3389/fphys.2026.1793838 [doi] PST - epublish SO - Front Physiol. 2026 Jun 10;17:1793838. doi: 10.3389/fphys.2026.1793838. eCollection 2026. PMID- 42359135 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Exploring predictors of low nutritional literacy in maintenance hemodialysis patients: a machine learning and network analysis approach. PG - 1862524 LID - 10.3389/fpubh.2026.1862524 [doi] LID - 1862524 AB - BACKGROUND: Patients undergoing maintenance hemodialysis (MHD) commonly experience substantial self-care challenges due to the complexity and highly restrictive nature of their treatment regimens. Nutritional literacy is a critical determinant of effective self-management in this population. However, the main predictors of low nutritional literacy and their relationships remain unclear, limiting early targeted interventions. This study aimed to identify important predictors of low nutritional literacy in MHD patients and to explore how these predictors relate to each other. METHODS: This study included 712 patients on maintenance hemodialysis (MHD). Latent profile analysis was used to identify individuals with low nutritional literacy, followed by machine learning to screen for key predictors. SHAP analysis was employed to visualize the importance of these predictors. Finally, network analysis was used to investigate the underlying relationships among the key predictors. RESULTS: The LightGBM model demonstrated the best predictive performance, with an AUC of 0.817 and an F1-score of 0.738. The LightGBM model identified nine key predictors: social support, depression, anxiety, self-efficacy, educational level, dialysis frequency, age, living arrangement (living with a spouse and children), and place of residence. Among these, social support had the highest SHAP value. Network analysis revealed that self-efficacy served as the central predictor(rs = 0.56), showing a significant positive correlation with social support (EW = 0.148) and significant negative correlations with depression and anxiety(EW = -0.209, EW = -0.158). The stability and accuracy analyses of the network demonstrated good overall stability, with a correlation stability (CS) coefficient for strength centrality of 0.67. In addition, the Bootstrap 95% confidence intervals were within an acceptable range. CONCLUSION: In this study, the LightGBM model was used to identify nine key predictors of low nutritional literacy in MHD patients. Self-efficacy was confirmed as a core node in the predictor network for low nutritional literacy in this population. These findings provide reliable empirical evidence for the early clinical identification of MHD patients at high risk for low nutritional literacy. Furthermore, using self-efficacy as a core intervention target, healthcare professionals can implement targeted interventions for high-risk populations to effectively improve their nutritional literacy. This study offers important practical guidance for optimizing nutritional literacy and intervention strategies for MHD patients. CI - Copyright (c) 2026 Yao, Liu, Tan, Chen and Fang. FAU - Yao, Ling AU - Yao L AD - School of Nursing, University of South China, Hengyang, China. FAU - Liu, Yanling AU - Liu Y AD - The First Affiliated Hospital of Shaoyang University, Shaoyang, China. FAU - Tan, Xufeng AU - Tan X AD - School of Nursing, University of South China, Hengyang, China. FAU - Chen, Sisi AU - Chen S AD - School of Nursing, University of South China, Hengyang, China. FAU - Fang, Yanchun AU - Fang Y AD - Department of Public Health, Central Hospital of Shaoyang, Shaoyang, China. LA - eng PT - Journal Article DEP - 20260610 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Renal Dialysis/psychology MH - Female MH - *Machine Learning MH - *Health Literacy/statistics & numerical data MH - Male MH - Middle Aged MH - Self Efficacy MH - Social Support MH - Aged MH - Self Care MH - Predictive Learning Models MH - *Nutritional Status PMC - PMC13292423 OTO - NOTNLM OT - machine learning OT - maintenance hemodialysis patients OT - network analysis OT - nutritional literacy OT - predictors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/10 CRDT- 2026/06/26 04:44 PHST- 2026/04/22 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 04:44 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1862524 [doi] PST - epublish SO - Front Public Health. 2026 Jun 10;14:1862524. doi: 10.3389/fpubh.2026.1862524. eCollection 2026. PMID- 42358574 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Urinary fatty acid binding protein 2 as a biomarker of intestinal injury in pediatric celiac disease. PG - 1838294 LID - 10.3389/fped.2026.1838294 [doi] LID - 1838294 AB - OBJECTIVES: Celiac disease (CeD) is an autoimmune enteropathy triggered by gluten in genetically predisposed individuals, causing intestinal damage and impaired gut barrier integrity. Current diagnostic methods, such as serology and intestinal biopsy, are costly and invasive. Intestinal fatty acid binding protein (FABP2), exclusively expressed in the cytosol of mature enterocytes and released during injury, offers a potential non-invasive alternative biomarker. This study aimed to evaluate urinary FABP2 levels in pediatric patients undergoing gastrointestinal assessment or CeD follow-up to determine its potential as a non-invasive biomarker of intestinal integrity. METHODS: In this retrospective cross-sectional study, urinary FABP2 was measured in 103 pediatric patients evaluated for intestinal permeability using the lactulose/mannitol test. Based on serology and symptomatology, patients were categorized as controls (n = 65), CeD on gluten-free diet (GFD) > 6 months (n = 26), or active CeD (n = 12). Associations between FABP2 levels, serology, symptoms, and diagnosis were analyzed. RESULTS: FABP2 levels were significantly elevated in active CeD patients (47.7 pg/mL) compared with controls (9.65 pg/mL) (p < 0.05), but not in CeD patients on GFD (15.0 pg/mL). A receiver operating characteristic curve analysis confirmed the diagnostic potential of FABP2 as a biomarker for celiac disease (area under the curve = 0.7269; cutoff = 23.7 pg/mL; sensitivity = 66.7%, specificity = 76.9%). CONCLUSION: Our findings indicate that urinary FABP2 reflects intestinal epithelial injury and may serve as a non-invasive biomarker for assessing gut integrity and disease activity in CeD. However, larger prospective studies with histological correlation are needed to validate its diagnostic utility. CI - (c) 2026 Mehta, Kapoor, Milliron, Stoeckel, Ballelos, Tiqui, Deb, Abomoelak, Schreck and Mehta. FAU - Mehta, Vijay AU - Mehta V AD - Pediatric Gastroenterology, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. FAU - Kapoor, Nidhi AU - Kapoor N AD - Specialty Diagnostic Clinical and Translational Research Lab, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. FAU - Milliron, Chloe AU - Milliron C AD - University of Central Florida, Orlando, FL, United States. FAU - Stoeckel, Noah AU - Stoeckel N AD - Specialty Diagnostic Clinical and Translational Research Lab, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. FAU - Ballelos, Edwin AU - Ballelos E AD - University of Central Florida, Orlando, FL, United States. FAU - Tiqui, Katrina AU - Tiqui K AD - University of Central Florida, Orlando, FL, United States. FAU - Deb, Chirajyoti AU - Deb C AD - University of Central Florida, Orlando, FL, United States. FAU - Abomoelak, Bassam AU - Abomoelak B AD - Specialty Diagnostic Clinical and Translational Research Lab, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. FAU - Schreck, Mary AU - Schreck M AD - Orlando Health Medical Group Pediatric Specialty Practice Resources, Orlando, FL, United States. FAU - Mehta, Devendra AU - Mehta D AD - Pediatric Gastroenterology, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. LA - eng PT - Journal Article DEP - 20260610 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13290442 OTO - NOTNLM OT - autoimmune enteropathy OT - biomarker OT - intestinal integrity OT - intestinal permeability test OT - leaky gut OT - mucosal damage COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/26 16:11 PMCR- 2026/06/10 CRDT- 2026/06/26 04:38 PHST- 2026/03/25 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/26 16:11 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 04:38 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.3389/fped.2026.1838294 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 10;14:1838294. doi: 10.3389/fped.2026.1838294. eCollection 2026. PMID- 42358305 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Comparative evaluation of nutritional risk screening tools in hospitalized children with acute gastroenteritis. PG - 1841518 LID - 10.3389/fnut.2026.1841518 [doi] LID - 1841518 AB - BACKGROUND: Malnutrition is common in hospitalized children with acute gastroenteritis, yet the optimal nutritional risk screening tool for this population remains unclear. This study aimed to compare the diagnostic performance and clinical utility of STRONGkids, PYMS, and STAMP in identifying malnutrition among hospitalized children with acute gastroenteritis. METHODS: In this multicenter retrospective study, children hospitalized with acute gastroenteritis between January 2024 and January 2026 were identified from electronic medical records at admission. After exclusions, 855 children were included in the final analysis. Nutritional risk was retrospectively assessed using STRONGkids, PYMS, and STAMP. Nutritional status was classified according to body mass index-for-age z scores based on the World Health Organization growth reference. Receiver operating characteristic curve analysis was used to evaluate discriminatory performance, with pairwise comparisons performed using the DeLong test. Optimal cut-off values were determined using the Youden index, and decision curve analysis was performed to assess clinical utility. RESULTS: Of the 855 children included, 82 were malnourished and 773 had normal nutritional status. Compared with children with normal nutritional status, malnourished children were younger and had more vomiting and diarrhea episodes, longer hospital stay, higher screening scores, and more severe dehydration. PYMS showed the best discriminatory performance, with an AUC of 0.860 (95% CI, 0.824-0.896), followed by STAMP at 0.796 (95% CI, 0.748-0.845) and STRONGkids at 0.717 (95% CI, 0.658-0.776). PYMS performed significantly better than both STRONGkids and STAMP, and STAMP also outperformed STRONGkids. At the optimal cut-off of 3, PYMS had the highest sensitivity, specificity, Youden index, and negative predictive value. Decision curve analysis also supported the superior clinical utility of PYMS. CONCLUSION: Among the three screening tools, PYMS demonstrated the best overall performance for identifying malnutrition in hospitalized children with acute gastroenteritis and may be the most suitable tool for early nutritional risk screening in this population. CI - Copyright (c) 2026 Zhao, Li, Lin, Zhang, Li, Liu, Zhao and Mao. FAU - Zhao, Yue AU - Zhao Y AD - Department of Nursing, Lianyungang Maternity and Child Health Hospital, Lianyungang, Jiangsu, China. FAU - Li, Ziyang AU - Li Z AD - Department of Pediatrics, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu, China. FAU - Lin, Mingyue AU - Lin M AD - Department of Pediatrics, The Affiliated Lianyungang Hospital of Xuzhou Medical University (The First People's Hospital of Lianyungang), Lianyungang, Jiangsu, China. FAU - Zhang, Juan AU - Zhang J AD - Department of Nursing, Lianyungang Maternity and Child Health Hospital, Lianyungang, Jiangsu, China. FAU - Li, Zhongxiang AU - Li Z AD - Department of Pediatrics, Ganyu District Hospital of Traditional Chinese Medicine, Lianyungang, Jiangsu, China. FAU - Liu, Jiangyan AU - Liu J AD - Department of Pediatrics, The Affiliated Lianyungang Hospital of Xuzhou Medical University (The First People's Hospital of Lianyungang), Lianyungang, Jiangsu, China. FAU - Zhao, Qianye AU - Zhao Q AD - Department of Pediatrics, Lianyungang Maternity and Child Health Hospital, Lianyungang, Jiangsu, China. FAU - Mao, Kangwei AU - Mao K AD - Department of Pediatrics, The Affiliated Lianyungang Hospital of Xuzhou Medical University (The First People's Hospital of Lianyungang), Lianyungang, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260610 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13290602 OTO - NOTNLM OT - PYMS OT - STAMP OT - STRONGkids OT - acute gastroenteritis OT - malnutrition OT - nutritional risk screening OT - pediatric nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/26 06:39 PMCR- 2026/06/10 CRDT- 2026/06/26 04:34 PHST- 2026/03/28 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/26 06:39 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 04:34 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.3389/fnut.2026.1841518 [doi] PST - epublish SO - Front Nutr. 2026 Jun 10;13:1841518. doi: 10.3389/fnut.2026.1841518. eCollection 2026. PMID- 42356915 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 12 DP - 2026 Jun 21 TI - Explainable Machine Learning Using Sensor-Derived Biomechanical Features to Classify Elevated VALR-Related Loading Across Midsole Hardness Conditions in School-Aged Boys. LID - 10.3390/s26123942 [doi] LID - 3942 AB - (1) Background: Changes in midsole hardness may affect lower-limb impact loading during forefoot strike (FFS) running in children, yet the biomechanical basis for discriminating elevated VALR-related loading remains unclear. (2) Methods: Fourteen school-aged boys performed FFS running tests in experimental shoes with four midsole hardness levels (37, 42, 47, and 52 Shore C). Lower-limb kinematics and surface electromyography (sEMG) data were collected during the dominant leg stance phase. After preprocessing, VALR was calculated from 336 valid trials, and 28 stance-phase biomechanical features were extracted, yielding a final machine-learning dataset of 324 trials after excluding incomplete feature data. VALR was used to compare loading changes and define trial-level elevated-loading labels based on the median VALR value. Classification models were evaluated under participant-level GroupKFold validation, and XGBoost was retained for exploratory SHAP analysis. (3) Results: VALR showed an upward trend with increasing hardness, but no statistically supported change point was identified. XGBoost achieved an accuracy of 75.93%, precision of 74.14%, recall of 79.63%, F1-value of 0.768, and pooled out-of-fold AUC of 0.738. SHAP analysis indicated that distal and non-sagittal kinematic features contributed most to model classification. (4) Conclusions: Elevated VALR-related loading during children's FFS running may be characterized by a multi-feature model-based pattern rather than a fixed midsole hardness threshold. FAU - Chen, Yiyao AU - Chen Y AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Gao, Zixiang AU - Gao Z AUID- ORCID: 0000-0002-4345-8201 AD - Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada. FAU - Li, Fengping AU - Li F AUID- ORCID: 0009-0001-2206-2750 AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Wang, Dongxu AU - Wang D AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Pan, Jianqi AU - Pan J AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Wang, Yucheng AU - Wang Y AUID- ORCID: 0009-0003-1962-4147 AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Chen, Diwei AU - Chen D AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Zhou, Zhanyi AU - Zhou Z AD - Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain. FAU - Gao, Lidong AU - Gao L AD - Department of Material Science and Technology, Audi Hungaria Faculty of Automotive Engineering, Szechenyi Istvan University, 9026 Gyor, Hungary. FAU - Chen, Kuiyu AU - Chen K AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Ye, Zhaolong AU - Ye Z AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Gu, Yaodong AU - Gu Y AUID- ORCID: 0000-0003-2187-9440 AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. AD - Department of Kinesiology, Hungarian University of Sports Science, 1123 Budapest, Hungary. LA - eng PT - Journal Article DEP - 20260621 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Male MH - Biomechanical Phenomena/physiology MH - Electromyography MH - Hardness/physiology MH - *Machine Learning MH - *Running/physiology MH - Child MH - Shoes MH - Boosting Machine Learning Algorithms PMC - PMC13307089 OTO - NOTNLM OT - SHAP OT - XGBoost OT - elevated VALR-related loading OT - forefoot strike OT - midsole hardness OT - school-aged boys COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/26 13:10 MHDA- 2026/06/27 07:40 PMCR- 2026/06/21 CRDT- 2026/06/26 01:19 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/15 00:00 [revised] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/06/27 07:40 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:19 [entrez] PHST- 2026/06/21 00:00 [pmc-release] AID - s26123942 [pii] AID - sensors-26-03942 [pii] AID - 10.3390/s26123942 [doi] PST - epublish SO - Sensors (Basel). 2026 Jun 21;26(12):3942. doi: 10.3390/s26123942. PMID- 42356815 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 12 DP - 2026 Jun 17 TI - Prediction of Nocturnal Hypoglycemia Following Exercise in Type 1 Diabetes Using Temporally Structured CGM-Derived Digital Biomarkers. LID - 10.3390/s26123842 [doi] LID - 3842 AB - Nocturnal hypoglycemia (NH) following exercise represents a critical challenge in the management of type 1 diabetes (T1D), particularly in pediatric populations, where its occurrence is associated with severe adverse outcomes and increased caregiver burden. This study aimed to identify an interpretable early signature based on CGM-derived digital biomarkers of post-exercise NH risk in children and adolescents with T1D. CGM data from 49 pediatric subjects (DirecNet cohort) were used to extract several CGM metrics across two temporal configurations: (i) Exercise + Cumulative, where features were computed over the exercise window and over an extended window spanning from exercise onset through recovery (16:00-17:00 and 16:00-22:00); and (ii) Exercise + Post-exercise, where features were computed separately over two non-overlapping intervals, capturing the exercise phase and the subsequent recovery phase (16:00-17:00 and 17:00-22:00). A Random Forest classifier was trained within a Leave-One-Out Cross Validation framework, incorporating variance inflation factor (VIF)-based multicollinearity filtering, minimum redundancy-maximum relevance (mRMR) feature selection, and SMOTE-based class balancing. The Exercise + Post-exercise configuration achieved superior performance: balanced accuracy (BA) = 76.9%, F1-score = 0.71, Area Under Receiver Operating Characteristic Curve (ROC-AUC) = 0.75, outperforming the Exercise + Cumulative configuration; this result was achieved using only five features: CONGA-15_EX (short-term glucose variability during exercise) emerged as the most robust predictor, alongside below_54 and above_250 (time spent in hypoglycemic and hyperglycemic ranges), MAG (mean absolute glucose change), and GRADE_hypo (hypoglycemia risk score). The generalizability of the temporal framework was further supported by independent validation on the OhioT1DM free-living cohort, where the Exercise + Post-exercise configuration (BA = 76.3%, ROC-AUC = 0.804) again outperformed the cumulative approach. These results suggest that a small set of interpretable CGM-derived features, extracted from the exercise and recovery windows, can effectively discriminate pediatric T1D subjects at risk of NH, supporting the development of lightweight CGM-only decision support tools for safer exercise management. FAU - Piersanti, Agnese AU - Piersanti A AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Manes, Gaia Maria AU - Manes GM AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Del Giudice, Libera Lucia AU - Del Giudice LL AUID- ORCID: 0009-0008-0723-1289 AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Burattini, Laura AU - Burattini L AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Gobl, Christian AU - Gobl C AD - Department of Obstetrics and Gynaecology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. FAU - Tura, Andrea AU - Tura A AUID- ORCID: 0000-0003-3466-5900 AD - CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127 Padova, Italy. FAU - Morettini, Micaela AU - Morettini M AUID- ORCID: 0000-0002-8327-8379 AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/blood MH - *Hypoglycemia/diagnosis/blood MH - Continuous Glucose Monitoring MH - *Biomarkers/blood MH - *Exercise/physiology MH - Adolescent MH - Child MH - Female MH - Male MH - Blood Glucose/analysis PMC - PMC13307307 OTO - NOTNLM OT - SMOTE OT - continuous glucose monitoring OT - exercise OT - feature engineering OT - machine learning OT - nocturnal hypoglycemia OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/27 07:40 PMCR- 2026/06/17 CRDT- 2026/06/26 01:19 PHST- 2026/05/07 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/27 07:40 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:19 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - s26123842 [pii] AID - sensors-26-03842 [pii] AID - 10.3390/s26123842 [doi] PST - epublish SO - Sensors (Basel). 2026 Jun 17;26(12):3842. doi: 10.3390/s26123842. PMID- 42356382 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 19 TI - Assessing the Nutritional and Neurodevelopmental Status in Children Attending Preschools in a Neighborhood in Bogota, Colombia. LID - 10.3390/nu18121996 [doi] LID - 1996 AB - Background: Early childhood nutrition is strongly associated with neurodevelopmental outcomes, particularly in socially vulnerable settings. Limited evidence is available describing the relationship between nutritional status, food security, and neurodevelopment among preschool children in low-income urban areas of Colombia. This study aimed to evaluate nutritional status, household food insecurity, and neurodevelopmental outcomes in children attending early childhood centers in El Codito, Bogota, and to explore the association between anthropometric indicators and neurodevelopmental performance. Methods: A cross-sectional study was conducted in children enrolled in community childcare centers. Nutritional status was assessed using anthropometric indicators according to World Health Organization growth standards, including weight for age, height for age, and body mass index for age. Neurodevelopment was evaluated using the Escala Abreviada de Desarrollo (EAD). Household food insecurity was measured through a validated questionnaire. Descriptive statistics were performed, and associations between variables were analyzed using correlation tests and group comparisons according to data distribution. Results: Most participants presented adequate nutritional status; however, a proportion of children showed risk of stunting or excess weight. Neurodevelopmental scores were generally within expected ranges, although variability was observed across developmental domains. Significant associations were identified between certain anthropometric indicators and neurodevelopmental outcomes. Moderate to severe household food insecurity was identified in 21.4% of participating households. Conclusions: Nutritional status and household food insecurity represent important contextual factors for child health in vulnerable urban populations. These findings highlight the importance of integrated nutritional and developmental monitoring strategies within early childhood programs. Further longitudinal studies are required to clarify causal pathways and to guide targeted public health interventions in similar contexts. FAU - Aguilera-Arino, Laura Sofia AU - Aguilera-Arino LS AD - Neuroscience Research Group (Neuros), Centro de Neurociencia-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Talero-Gutierrez, Claudia AU - Talero-Gutierrez C AUID- ORCID: 0000-0003-1601-5015 AD - Neuroscience Research Group (Neuros), Centro de Neurociencia-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Velez-Van-Merbeeke, Alberto AU - Velez-Van-Merbeeke A AUID- ORCID: 0000-0002-8889-4170 AD - Neuroscience Research Group (Neuros), Centro de Neurociencia-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Pedraza-Lopez, Natalia AU - Pedraza-Lopez N AUID- ORCID: 0009-0001-3491-5212 AD - Clinical Research Group-Epidemiological Studies Line, School of Medicine and Health Sciences, Universidad del Rosario, Quinta de Mutis Campus, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Patino-Rattiva, Maria AU - Patino-Rattiva M AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Pastrana-Bustamante, Isabella AU - Pastrana-Bustamante I AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Ospina-Arias, Juan Andres AU - Ospina-Arias JA AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Quijano-Zauner, Mariana AU - Quijano-Zauner M AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Velasquez, Maria Jose AU - Velasquez MJ AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Carvajal-Rincon, Sara Sofia AU - Carvajal-Rincon SS AUID- ORCID: 0009-0001-7394-5588 AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Pinzon-Rondon, Angela Maria AU - Pinzon-Rondon AM AD - Clinical Research Group-Epidemiological Studies Line, School of Medicine and Health Sciences, Universidad del Rosario, Quinta de Mutis Campus, Carrera 24 #63c-69, Bogota 111221, Colombia. LA - eng PT - Journal Article DEP - 20260619 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Colombia/epidemiology MH - *Nutritional Status MH - Child, Preschool MH - Cross-Sectional Studies MH - Female MH - Male MH - Neurodevelopment MH - *Child Development MH - Food Insecurity MH - Anthropometry MH - Urban Population MH - Poverty PMC - PMC13305189 OTO - NOTNLM OT - anthropometry OT - child development OT - malnutrition OT - neurodevelopmental disorders OT - nutritional status COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:40 MHDA- 2026/06/27 07:10 PMCR- 2026/06/19 CRDT- 2026/06/26 01:17 PHST- 2026/05/12 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:40 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - nu18121996 [pii] AID - nutrients-18-01996 [pii] AID - 10.3390/nu18121996 [doi] PST - epublish SO - Nutrients. 2026 Jun 19;18(12):1996. doi: 10.3390/nu18121996. PMID- 42356370 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 19 TI - Eating Disorder Risk Among Italian University Students: A Cross-Sectional Screening Study Using BMI, EAT-26, and EDE-Q 6.0. LID - 10.3390/nu18121984 [doi] LID - 1984 AB - Background/Objectives: Eating disorders (EDs) are among the most severe psychiatric conditions affecting young people, with increasing prevalence in the post-pandemic period. This study assessed the prevalence of ED risk and dysfunctional eating behaviors among Italian university students, a population poorly characterized with respect to ED risk, and examined associations with key socio-demographic and anthropometric variables. Methods: A cross-sectional online screening study was conducted between August 2023 and February 2026 with 401 Italian university students (306 women and 95 men). Participants completed the validated Italian versions of the Eating Attitudes Test-26 (EAT-26) and the Eating Disorder Examination Questionnaire 6.0 (EDE-Q 6.0), alongside self-reported anthropometric data. Multiple linear regression analyses were performed to identify predictors of ED risk scores. Results: A total of 37.9% of participants had BMI outside the normal range (19.7% underweight; 18.2% overweight or obese). EAT-26 scores exceeded the clinical cut-off in 28.4% of participants (women: 35.6%; men: 5.3%). EDE-Q 6.0 global scores exceeded the clinical cut-off in 21.0% (women: 25.8%; men: 5.3%). Only 45.4% showed no anthropometric or questionnaire-based screening risk indicators (i.e., scores above the clinical cut-off on the EAT-26 or EDE-Q 6.0). BMI was negatively associated with EAT-26 scores in the total sample and in women, while a positive association between BMI and EDE-Q 6.0 scores was observed in men. Conclusions: A substantial proportion of Italian university students, particularly women, presented screening-based indicators of ED risk. The combined use of anthropometric and questionnaire-based screening tools provides a more comprehensive risk assessment than either measure alone, highlighting the need for multidimensional screening programs. FAU - Gosti, Valeria AU - Gosti V AUID- ORCID: 0009-0000-6071-2497 AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, 00193 Rome, Italy. AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Coletta, Antonella AU - Coletta A AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Vinci, Andrea Carolina AU - Vinci AC AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Massaro, Francesca AU - Massaro F AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Foti, Francesca AU - Foti F AD - Department of Educational Sciences, University of Catania, 95124 Catania, Italy. FAU - Koch, Giacomo AU - Koch G AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. AD - Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. FAU - Gelfo, Francesca AU - Gelfo F AUID- ORCID: 0000-0002-3935-2164 AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, 00193 Rome, Italy. AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Betti, Viviana AU - Betti V AUID- ORCID: 0000-0003-3429-2104 AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. AD - Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy. FAU - Petrosini, Laura AU - Petrosini L AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Picazio, Silvia AU - Picazio S AUID- ORCID: 0000-0002-1784-7537 AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, 00193 Rome, Italy. AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. LA - eng GR - GR-2019-2369640/Ministry of Health/ PT - Journal Article DEP - 20260619 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - Italy/epidemiology MH - *Feeding and Eating Disorders/epidemiology/diagnosis MH - *Students/psychology/statistics & numerical data MH - *Body Mass Index MH - Young Adult MH - Universities MH - Adult MH - Surveys and Questionnaires MH - Risk Factors MH - Prevalence MH - Adolescent MH - Feeding Behavior/psychology PMC - PMC13304807 OTO - NOTNLM OT - EAT-26 OT - EDE-Q 6.0 OT - body mass index OT - eating disorders OT - gender differences OT - university students COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/19 CRDT- 2026/06/26 01:17 PHST- 2026/05/11 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - nu18121984 [pii] AID - nutrients-18-01984 [pii] AID - 10.3390/nu18121984 [doi] PST - epublish SO - Nutrients. 2026 Jun 19;18(12):1984. doi: 10.3390/nu18121984. PMID- 42356367 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 18 TI - Effect of School-Based Physical Activity and Multi Micronutrient Supplementation on Micronutrient Concentrations Among Tanzanian Schoolchildren: Secondary Outcomes from the KaziAfya Cluster-Randomized Controlled Trial. LID - 10.3390/nu18121980 [doi] LID - 1980 AB - Background: Micronutrient deficiencies and physical inactivity can adversely affect child growth and development. This study assessed the effects of school-based physical activity and multi-micronutrient supplementation on micronutrient status among schoolchildren in Kilombero district, Tanzania. Methods: In a cluster-randomized trial, children aged 6-12 years were allocated to physical activity, multi-micronutrient supplementation, combined physical activity plus supplementation, or placebo control. Anthropometric and biochemical assessments were conducted at baseline, 14 months, and 26 months. Dried blood spot samples were available for 923 children at baseline. Complete-case analyses used biomarker-specific subsamples with valid baseline and 26-month measurements. Results: The primary complete-case sample included 243 children with valid paired measurements for zinc and serum transferrin receptor; vitamin D analyses were restricted to 52 children because of missing or invalid samples. At baseline, iron and vitamin D deficiencies were common, affecting 42.8% and 39.9% of children, respectively, while zinc deficiency affected 11.9%. At 26 months, allocation to the physical activity intervention was associated with lower odds of zinc deficiency, both when delivered alone (OR = 0.16) and when combined with supplementation (OR = 0.57). Supplementation alone was not significantly associated with reduced zinc deficiency. Iron status did not differ between intervention groups. Vitamin D findings should be interpreted with caution because analyses were based on a very small biomarker-specific subsample. Conclusions: School-based physical activity, alone or combined with multi-micronutrient supplementation, was associated with lower odds of zinc deficiency among Tanzanian schoolchildren. Supplementation alone showed no clear benefit for zinc or iron status. Vitamin D findings remain inconclusive because of substantial biomarker-specific missingness. Future trials should strengthen adherence monitoring, biomarker follow-up, and repeated assessment of dietary and contextual factors. FAU - Minja, Elihaika G AU - Minja EG AUID- ORCID: 0000-0002-8142-5427 AD - Department of Environmental Health and Ecological Sciences, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania. AD - Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123 Allschwil, Switzerland. AD - Faculty of Medicine, University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland. FAU - Mrimi, Emmanuel C AU - Mrimi EC AUID- ORCID: 0000-0002-6707-7040 AD - Department of Environmental Health and Ecological Sciences, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania. AD - Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123 Allschwil, Switzerland. AD - Faculty of Medicine, University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland. FAU - Mponzi, Winfrida P AU - Mponzi WP AD - Department of Environmental Health and Ecological Sciences, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania. AD - School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa. FAU - Beckmann, Johanna AU - Beckmann J AUID- ORCID: 0000-0002-3912-0128 AD - Department of Sport, Exercise and Health, University of Basel, Grosse Allee 6, CH-4052 Basel, Switzerland. FAU - Finda, Marceline F AU - Finda MF AD - Department of Environmental Health and Ecological Sciences, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania. AD - School of Life Science and Bioengineering, Nelson Mandela African Institution of Science & Technology, Arusha P.O. Box 447, Tanzania. FAU - Okumu, Fredros O AU - Okumu FO AD - Department of Environmental Health and Ecological Sciences, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania. AD - School of Life Science and Bioengineering, Nelson Mandela African Institution of Science & Technology, Arusha P.O. Box 447, Tanzania. AD - School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow G12 8QQ, UK. FAU - Lang, Christin AU - Lang C AUID- ORCID: 0000-0002-2532-9019 AD - Department of Sport, Exercise and Health, University of Basel, Grosse Allee 6, CH-4052 Basel, Switzerland. FAU - Gerber, Markus AU - Gerber M AUID- ORCID: 0000-0001-6140-8948 AD - School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa. FAU - Utzinger, Jurg AU - Utzinger J AD - Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123 Allschwil, Switzerland. AD - Faculty of Medicine, University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland. FAU - Long, Kurt Z AU - Long KZ AD - Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123 Allschwil, Switzerland. AD - Faculty of Medicine, University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland. LA - eng GR - 6071/Fondation Botnar/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260618 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Micronutrients) RN - J41CSQ7QDS (Zinc) RN - 0 (Biomarkers) RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - Child MH - Tanzania/epidemiology MH - *Micronutrients/administration & dosage/deficiency/blood MH - *Dietary Supplements MH - Female MH - Zinc/blood/deficiency MH - Male MH - *Exercise MH - Nutritional Status MH - Schools MH - Biomarkers/blood MH - Vitamin D/blood MH - Vitamin D Deficiency/prevention & control/epidemiology PMC - PMC13304761 OTO - NOTNLM OT - micronutrients status OT - multi-micronutrient supplementation OT - physical activity OT - randomized controlled trial OT - school children COIS- The authors declare that this study received funding from DSM Nutritional Products Ltd. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/18 CRDT- 2026/06/26 01:17 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - nu18121980 [pii] AID - nutrients-18-01980 [pii] AID - 10.3390/nu18121980 [doi] PST - epublish SO - Nutrients. 2026 Jun 18;18(12):1980. doi: 10.3390/nu18121980. PMID- 42356337 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 17 TI - Ultra-Processed Food Consumption Is Independently Associated with Higher HbA1c and Poor Glycemic Control in Adults with Type 2 Diabetes. LID - 10.3390/nu18121951 [doi] LID - 1951 AB - Background/Objectives: Ultra-processed food (UPF) consumption has been linked to type 2 diabetes mellitus (T2DM) incidence, but its association with glycemic control in individuals already living with T2DM remains less well characterized. We evaluated the relationship between UPF consumption, assessed with the Turkish version of the short Screening Questionnaire of Highly Processed Food Consumption (sQ-HPF), and HbA1c and poor glycemic control in adults with T2DM. Methods: In this single-centre, cross-sectional observational study, 425 adults aged 18-65 years with T2DM of at least 6 months' duration were consecutively recruited at a tertiary general internal medicine outpatient clinic. UPF consumption was assessed with the Turkish sQ-HPF (range 0-11; scores >/= 6 = high UPF consumption). HbA1c was the primary outcome (continuous and dichotomized at 7.0%). Multiple linear and binary logistic regression analyses were performed with hierarchical adjustment for age, sex, body mass index (BMI), diabetes duration, and insulin-based treatment. Results: Total UPF score was positively correlated with HbA1c (r = 0.423, p < 0.001). In the fully adjusted linear model, each one-point increase in total UPF score was associated with a 0.418% higher HbA1c (95% CI: 0.333-0.503; beta = 0.413; p < 0.001), explaining 28.9% of HbA1c variance. In the fully adjusted logistic model, each one-point increase in total UPF score was associated with 25.0% higher odds of poor glycemic control (OR = 1.250, 95% CI: 1.110-1.408, p < 0.001). Insulin-based treatment and male sex were also independent predictors. UPF score was not significantly associated with lipid parameters or C-reactive protein. Conclusions: Higher UPF consumption, captured by a brief validated screener, was independently associated with poorer glycemic control in Turkish adults with T2DM. Brief UPF screening may help identify patients who would benefit from targeted nutritional intervention. FAU - Otay Lule, Nezihe AU - Otay Lule N AUID- ORCID: 0000-0003-3664-6383 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gaziantep University, 27310 Gaziantep, Turkiye. FAU - Sahin, Serpil AU - Sahin S AUID- ORCID: 0009-0009-7541-202X AD - Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkiye. FAU - Lule, Kemal Ozan AU - Lule KO AUID- ORCID: 0000-0003-3582-9663 AD - Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkiye. FAU - Yildiz, Hamit AU - Yildiz H AUID- ORCID: 0000-0001-7858-5123 AD - Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkiye. LA - eng PT - Journal Article PT - Observational Study DEP - 20260617 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/blood MH - Middle Aged MH - Male MH - Female MH - *Glycated Hemoglobin/metabolism/analysis MH - Adult MH - Cross-Sectional Studies MH - *Glycemic Control MH - Food, Processed MH - Aged MH - *Blood Glucose/metabolism MH - *Fast Foods/adverse effects MH - Young Adult MH - Adolescent MH - Turkey PMC - PMC13304910 OTO - NOTNLM OT - HbA1c OT - cardiometabolic risk OT - glycemic control OT - sQ-HPF OT - type 2 diabetes mellitus OT - ultra-processed food COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/17 CRDT- 2026/06/26 01:17 PHST- 2026/05/27 00:00 [received] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - nu18121951 [pii] AID - nutrients-18-01951 [pii] AID - 10.3390/nu18121951 [doi] PST - epublish SO - Nutrients. 2026 Jun 17;18(12):1951. doi: 10.3390/nu18121951. PMID- 42356329 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 16 TI - Ketogenic Diet for Intensive Care Patients: A Scoping Review. LID - 10.3390/nu18121943 [doi] LID - 1943 AB - BACKGROUND: Critical illness leads to profound metabolic, neuroendocrine and immune disorders that affect the prognosis of patients treated in intensive care units (ICUs). The ketogenic diet, a high-fat and low-carbohydrate eating model, is gaining increasing importance as a potential metabolic intervention in the ICU. Preliminary data suggest that the ketogenic diet (KD) may support the control of seizures in a super-refractive epileptic state (SRSE), stabilize glycemia, reduce insulin demand, and modulate the immune response in sepsis. The aim of this review was to present a synthetic presentation of the current state of knowledge regarding use of the KD in intensive care patients. METHODS: The review was carried out in accordance with the guidelines of the Joanna Briggs Institute and PRISMA-ScR. PubMed, Scopus, EBSCO, Web of Science, Google Scholar and Cochrane Library databases were searched (10-19 April 2026) using the Population-Concept-Context model. Full-text observational studies, randomized trials and reviews of the use of KDs in ICU patients were included. Data extraction was performed independently by two reviewers. RESULTS: Of the 42 publications identified, seven studies were included in the analysis. The KD was feasible and safe in both critically ill adults and children. In SRSE, most patients achieved stable ketosis within a few days, which often allowed for reduction or discontinuation of anesthetics. In sepsis, the KD led to glycemic stabilization, reduced insulin demand and reduced immune deregulation; in one study, "after day 4, none of the patients in the KD group required insulin treatment." The KD also showed beneficial effects on cellular bioenergetics and mitochondrial function. The safety profile was acceptable and adverse reactions were manageable with appropriate monitoring. CONCLUSIONS: The KD represents a promising, non-pharmacological metabolic intervention in intensive care, particularly in the treatment of SRSE and in the stabilization of glucose metabolism in sepsis and other critical conditions. Despite the growing number of positive clinical observations, the available evidence remains limited due to small samples, heterogeneous protocols, and a lack of randomized trials. Further, well-designed prospective studies are needed to determine optimal KD implementation protocols and identify the patient populations that benefit most. FAU - Bryla, Julia AU - Bryla J AUID- ORCID: 0009-0006-6683-6419 AD - Institute of Nursing, Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, 35-310 Rzeszow, Poland. FAU - Szczupak, Mateusz AU - Szczupak M AUID- ORCID: 0009-0009-3094-2385 AD - Department of Anaesthesiology and Intensive Therapy in the Nicolaus Copernicus Hospital in Gdansk, 80-803 Gdansk, Poland. FAU - Krupa-Nurcek, Sabina AU - Krupa-Nurcek S AUID- ORCID: 0000-0002-3002-3153 AD - Department of Surgery, Faculty of Medicine, Collegium Medicum, University of Rzeszow, 35-310 Rzeszow, Poland. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260616 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Blood Glucose) RN - 0 (Insulin) SB - IM MH - Humans MH - Blood Glucose/metabolism MH - *Critical Care/methods MH - Critical Illness/therapy MH - *Diet, Ketogenic/methods MH - Insulin MH - Intensive Care Units MH - Sepsis/diet therapy PMC - PMC13305233 OTO - NOTNLM OT - KD OT - diet OT - intensive care OT - intensive therapy COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/16 CRDT- 2026/06/26 01:17 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - nu18121943 [pii] AID - nutrients-18-01943 [pii] AID - 10.3390/nu18121943 [doi] PST - epublish SO - Nutrients. 2026 Jun 16;18(12):1943. doi: 10.3390/nu18121943. PMID- 42356324 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 15 TI - Green Tea Consumption and Risk of All-Cause Mortality: Findings from a Prospective Cohort Study. LID - 10.3390/nu18121937 [doi] LID - 1937 AB - BACKGROUND/OBJECTIVES: There has been a growing concern about excessive caffeine consumption among heavy green tea drinkers on health outcomes, such as cardiovascular diseases or cancer. We evaluated the association between green tea consumption and risk of all-cause mortality in Vietnam. METHODS: We used data from the Hanoi Prospective Cohort Study, an ongoing study comprising 42,146 participants aged 10 or older in Northern Vietnam who have been followed up between 2007 and 2019. Green tea intake was derived from a validated semi-quantitative food frequency questionnaire. We performed a Cox proportional hazard regression model to calculate the hazard ratio (HR) and respective 95% confidence intervals (95% CIs) for the association between green tea consumption and risk of all-cause mortality, adjusted for potential confounding factor. RESULTS: After a median follow-up of 11 years (range: 0.13-11.64 years), we identified 2494 deaths. Overall, there was an inverse association between green tea intake and risk of all-cause mortality (HR(perSDincrement) = 0.93; 95% CI, 0.89-0.97, P(trend) < 0.001). This pattern was more pronounced in males (HR(perSDincrement) = 0.93; 95% CI, 0.89-0.97, P(trend) < 0.001) but not in females (HR(perSDincrement) = 0.94; 95% CI, 0.86-1.02, P(trend) = 0.12; P(heterogeneity) = 0.81). In stratified analysis, the inverse association pattern was seen in both younger and old age groups, in individuals with BMI < 23 kg/m(2), in both ever and never smokers, among ever alcohol drinkers and never coffee drinkers, and in individuals with and without history of type 2 diabetes (P(heterogeneity) = 0.31). CONCLUSIONS: Findings from the current study, the first prospective cohort study in Vietnam, suggest a protective effect of green tea consumption on risk of all-cause mortality. Further studies are warranted to validate our findings in similar population and settings. FAU - Le, Ngoan Tran AU - Le NT AUID- ORCID: 0000-0001-7862-492X AD - Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam. AD - Department of Clinical Research, Vinmec Healthcare System, Hanoi 100000, Vietnam. FAU - Pham, Yen Thi-Hai AU - Pham YT AD - University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA. AD - Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA. FAU - Nguyen, Hieu Lan AU - Nguyen HL AD - Department of Cardiovascular Diseases, Hanoi Medical University, Hanoi 100000, Vietnam. FAU - Le, Linh Thuy AU - Le LT AD - Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR (National Institute of Health and Medical Research, Mixed Research Unit), 75015 Paris, France. FAU - Nguyen, Ninh Thi AU - Nguyen NT AUID- ORCID: 0009-0008-6658-8675 AD - Department of Occupational Health, Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam. FAU - Vu, Thao Thu Thi AU - Vu TTT AUID- ORCID: 0009-0007-0413-3707 AD - General Daycare Inpatient Department, Hanoi Oncology Hospital, Hanoi 100000, Vietnam. FAU - Koriyama, Chihaya AU - Koriyama C AUID- ORCID: 0000-0003-3676-8866 AD - Department of Epidemiology and Preventive Medicine, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima 890-8544, Japan. FAU - Nguyen, Ha AU - Nguyen H AD - Department of Computer Science, Wayne State University, Detroit, MI 48202, USA. FAU - Nguyen, Tin C AU - Nguyen TC AUID- ORCID: 0000-0001-8001-9470 AD - Department of Industrial and Systems Engineering, Wayne State University, Detroit, MI 48202, USA. AD - Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA. FAU - Vo, Nam S AU - Vo NS AD - VinUni Big Data Research Institute, VinUniversity, Hanoi 100000, Vietnam. FAU - Wu, Lang AU - Wu L AD - LSU-LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. FAU - Cullen, Jennifer AU - Cullen J AD - Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA. AD - Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. FAU - Luu, Hung N AU - Luu HN AUID- ORCID: 0000-0002-2172-1849 AD - University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA. AD - Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA. AD - Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. LA - eng PT - Journal Article DEP - 20260615 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Tea) SB - IM MH - Humans MH - *Tea MH - Male MH - Prospective Studies MH - Female MH - Middle Aged MH - Vietnam/epidemiology MH - Risk Factors MH - Adult MH - Proportional Hazards Models MH - *Mortality MH - Adolescent MH - Young Adult MH - Child MH - Cause of Death MH - Aged PMC - PMC13304542 OTO - NOTNLM OT - Vietnam OT - all-cause mortality OT - green tea OT - prospective cohort study OT - risk COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 10:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/15 CRDT- 2026/06/26 01:17 PHST- 2026/03/31 00:00 [received] PHST- 2026/06/07 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 10:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - nu18121937 [pii] AID - nutrients-18-01937 [pii] AID - 10.3390/nu18121937 [doi] PST - epublish SO - Nutrients. 2026 Jun 15;18(12):1937. doi: 10.3390/nu18121937. PMID- 42356309 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 13 TI - Completion Rates of Food Frequency Questionnaires and Food Records in People with Chronic Conditions: Systematic Review and Meta-Analysis. LID - 10.3390/nu18121922 [doi] LID - 1922 AB - Background/Objectives: Dietary assessment tools are essential for quantifying food and nutrient intake, characterising dietary patterns, and informing nutrition research. Food Frequency Questionnaires (FFQs) and Food Records (FRs) are widely implemented in observational studies, but completion rates vary, which may compromise data quality, introduce bias, and limit the interpretation of findings. This review is intended to synthesise evidence from observational studies on completion rates of these tools in populations with chronic conditions. Methods: A systematic search of Medline, PubMed, Scopus, and Google Scholar was completed. Eligible studies were observational studies using an FFQ or FR published from January 2015 to May 2025 in people with a chronic condition. Methodological quality was evaluated using the Hoy Risk of Bias tool for observational studies of prevalence. Subgroup meta-analyses estimated pooled mean completion proportions with 95% confidence intervals, and heterogeneity was assessed using the I(2) statistic. This study was registered with the International Prospective Register of Systematic Reviews and reported according to PRISMA guidelines. Results: Of the 8921 records screened, 88 studies (n = 84,579 participants) met inclusion criteria. The combined FFQ and food record mean pooled completion rate was 79.1% (95% Confidence Interval (CI): 74.37-83.43%). However, substantial heterogeneity was observed, indicating considerable variability across studies. Subgroup analyses highlighted important differences by tool type, format, age group, and disease category. FFQs demonstrated higher completion rates (80.6%) than FRs (74.3%). Electronic formats had higher completion rates than paper formats. Completion rates were higher in adults than in pediatric cohorts, and varied by chronic condition type, with kidney disease associated with the highest completion rates. Conclusions: These findings highlight the importance of considering tailored dietary data collection strategies, particularly for paediatric and medically complex populations, and provide direction for enhancing the feasibility of dietary assessment collection in future research. FAU - Kyei, Amanda AU - Kyei A AD - School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Miglioretto, Chiara AU - Miglioretto C AUID- ORCID: 0009-0005-2013-3155 AD - School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW 2500, Australia. AD - Health Innovations, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Perez, Geraldine AU - Perez G AD - School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW 2500, Australia. AD - Health Innovations, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Lambert, Kelly AU - Lambert K AUID- ORCID: 0000-0001-5935-7328 AD - School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW 2500, Australia. AD - Health Innovations, University of Wollongong, Wollongong, NSW 2500, Australia. AD - Kidney Lifestyle Research Group, University of Wollongong, Wollongong, NSW 2500, Australia. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260613 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Chronic Disease MH - *Diet Records MH - *Nutrition Assessment MH - *Diet Surveys MH - Surveys and Questionnaires MH - Observational Studies as Topic MH - Female MH - Feeding Behavior MH - Adult MH - Diet MH - Male MH - Middle Aged PMC - PMC13306072 OTO - NOTNLM OT - chronic disease OT - dietary assessment OT - food frequency questionnaire OT - food record OT - meta-analysis OT - observational study OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:40 PMCR- 2026/06/13 CRDT- 2026/06/26 01:17 PHST- 2026/05/03 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/06/27 07:40 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - nu18121922 [pii] AID - nutrients-18-01922 [pii] AID - 10.3390/nu18121922 [doi] PST - epublish SO - Nutrients. 2026 Jun 13;18(12):1922. doi: 10.3390/nu18121922. PMID- 42356288 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 12 TI - Household Food Insecurity Risk and Weight Status Outcomes in Early Childhood: A Public Health Perspective. LID - 10.3390/nu18121900 [doi] LID - 1900 AB - BACKGROUND: Household food insecurity (HFI), defined as the lack of reliable access to adequate food because of limited money or resources, may influence children's nutritional status. This study aimed to examine the association between HFI risk, based on a single screening item, and underweight and obesity among kindergarten children in Nevada. METHODS: Cross-sectional data from the Kindergarten Health Survey (KHS) collected across three school years (2022-2023, 2023-2024, and 2024-2025) were analyzed using a pooled sample of 7267 children. HFI risk was assessed using one item from the Hunger Vital Sign. Weight status was determined using Body Mass Index (BMI) guidelines from the Centers for Disease Control and Prevention (CDC). Descriptive statistics and multinomial logistic regression examined associations between HFI risk and underweight and obesity, adjusting for confounders. RESULTS: Across the pooled sample, 16.3% were at risk for HFI, 16.0% were underweight, and 21.9% had obesity. In pooled analysis, HFI risk was associated with higher odds of obesity (Adjusted Odds Ratio [AOR] 1.29; 95% Confidence Interval [CI]: 1.05-1.59), but not underweight, compared with food-secure children. In year-specific analyses, higher odds of underweight were observed in 2023-2024 (AOR 1.74; 95% CI: 1.14-2.66) and 2024-2025 (AOR 1.58; 95% CI: 1.04-2.38). CONCLUSIONS: HFI risk was associated with obesity among kindergarten children in Nevada, while associations with underweight were observed only in certain school years and should be interpreted cautiously. These findings suggest HFI risk as an important early childhood health concern and support the need for nutrition support, family assistance, and longitudinal research. FAU - Haboush-Deloye, Amanda AU - Haboush-Deloye A AUID- ORCID: 0000-0001-8887-3452 AD - Nevada Institute for Children's Research and Policy, School of Public Health, University of Nevada Las Vegas, Las Vegas, NV 89119, USA. AD - Department of Social and Behavioral Health, School of Public Health, University of Nevada Las Vegas, Las Vegas, NV 89119, USA. FAU - Neupane, Smriti AU - Neupane S AUID- ORCID: 0009-0009-6463-1526 AD - Nevada Institute for Children's Research and Policy, School of Public Health, University of Nevada Las Vegas, Las Vegas, NV 89119, USA. FAU - Buccini, Gabriela AU - Buccini G AUID- ORCID: 0000-0001-6008-0987 AD - Department of Social and Behavioral Health, School of Public Health, University of Nevada Las Vegas, Las Vegas, NV 89119, USA. LA - eng PT - Journal Article DEP - 20260612 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Food Insecurity MH - Child, Preschool MH - Female MH - Male MH - Cross-Sectional Studies MH - *Thinness/epidemiology MH - Nevada/epidemiology MH - Nutritional Status MH - *Family Characteristics MH - *Public Health MH - Risk Factors MH - *Pediatric Obesity/epidemiology MH - Body Mass Index MH - *Body Weight MH - Child PMC - PMC13306024 OTO - NOTNLM OT - body mass index OT - children OT - household food insecurity OT - kindergarten OT - nutrition OT - obesity OT - underweight COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:40 PMCR- 2026/06/12 CRDT- 2026/06/26 01:17 PHST- 2026/04/29 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/27 07:40 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - nu18121900 [pii] AID - nutrients-18-01900 [pii] AID - 10.3390/nu18121900 [doi] PST - epublish SO - Nutrients. 2026 Jun 12;18(12):1900. doi: 10.3390/nu18121900. PMID- 42356286 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 11 TI - Socio-Demographic and Anthropometric Findings of Women Caregivers in Qwa-Qwa, Free State Province, South Africa. LID - 10.3390/nu18121898 [doi] LID - 1898 AB - Background: Women remain the primary caregivers globally, especially in rural, low-resource settings plagued by poverty, unemployment, low education and poor infrastructure. These factors limit caregiving capacity, heighten vulnerability and increase the risk of food insecurity in female-headed households. Objective: To establish a baseline profile of caregivers of primary school children. Methods: Phase 1 (baseline) of the study was conducted using a quantitative, exploratory cross-sectional survey design among 75 female caregivers of children aged 7-13 years in Qwa-Qwa, Free State Province. Participants were recruited using convenience sampling. Data were collected with a structured, pre-validated questionnaire on socio-demographics, alongside anthropometric measurements. Data were analysed using descriptive statistics. Results: Most participants were unemployed (73.3%) and had low educational attainment, with 86.7% having completed primary school or less. A substantial proportion of households (80.0%) reported a monthly income below R1000. Food insecurity was common, with 69.3% of caregivers reporting experiences of food shortages. Household infrastructure was limited, particularly in refuse removal services (96.0% without access). Despite these socio-economic constraints, a high prevalence of overweight and obesity (72.5%) was observed amongst the participants. Conclusions: Caregivers experience severe, overlapping socio-economic and environmental vulnerabilities alongside a high prevalence of overweight and obesity. The study highlights the need for multi-sectoral interventions focused on poverty reduction, rural infrastructure development, improved service delivery, women's empowerment and strengthened livelihood opportunities to improve household nutrition and resilience. FAU - Mangwane, Queen E M AU - Mangwane QEM AUID- ORCID: 0000-0002-3863-4135 AD - Department of Hospitality Management, Faculty of Management Sciences, Tshwane University of Technology, Pretoria 0001, South Africa. FAU - Egal, Abdulkadir AU - Egal A AUID- ORCID: 0000-0003-0303-6319 AD - Department of Tourism & Integrated Communication, Faculty of Human Sciences, Vaal University of Technology, Vanderbijlpark 1900, South Africa. FAU - Oosthuizen, Delia AU - Oosthuizen D AUID- ORCID: 0000-0001-7570-270X AD - Department of Tourism & Integrated Communication, Faculty of Human Sciences, Vaal University of Technology, Vanderbijlpark 1900, South Africa. LA - eng PT - Journal Article DEP - 20260611 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - South Africa/epidemiology MH - *Caregivers/statistics & numerical data MH - Cross-Sectional Studies MH - Child MH - Adolescent MH - Food Insecurity MH - Anthropometry MH - Adult MH - Socioeconomic Factors MH - Poverty MH - Overweight/epidemiology MH - Middle Aged MH - Food Supply MH - Obesity/epidemiology MH - Rural Population MH - Prevalence MH - Family Characteristics MH - Surveys and Questionnaires MH - Sociodemographic Factors PMC - PMC13304777 OTO - NOTNLM OT - anthropometric status OT - malnutrition OT - socioeconomic vulnerability OT - women caregivers COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/11 CRDT- 2026/06/26 01:17 PHST- 2026/04/20 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - nu18121898 [pii] AID - nutrients-18-01898 [pii] AID - 10.3390/nu18121898 [doi] PST - epublish SO - Nutrients. 2026 Jun 11;18(12):1898. doi: 10.3390/nu18121898. PMID- 42356284 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 11 TI - Sex-Stratified Correlates of Pulmonary Function in Mexican Children and Adolescents (6-17 Years) with Asthma: An Exploratory Analysis of HDL Cholesterol, BMI, and Pubertal Stage. LID - 10.3390/nu18121885 [doi] LID - 1885 AB - Background/Objectives: Pubertal maturation encompasses hormonal, somatic, and metabolic alterations that may influence pulmonary function in children with asthma. We evaluated the correlates of pulmonary function in pediatric asthma using sex-stratified analyses of pubertal stage, BMI z-score, asthma control (ACQ-6), and HDL cholesterol levels on FEV1, FVC, and the FEV1/FVC ratio (% predicted, NHANES III). Methods: A cross-sectional study was conducted with 118 children and adolescents with asthma (74 males and 44 females). The Tanner stages were categorized as pre-/early (I-II), mid (III), and late (IV). No participant had reached Tanner stage V at recruitment, and the reference category was composed predominantly of Tanner II participants; therefore, the pubertal contrast reflected early- versus mid-/late-pubertal physiology rather than a strictly prepubertal-versus-pubertal comparison. We performed hierarchical linear regression with bias-corrected and accelerated bootstrap inference (5000 replicates) for each sex and for all participants combined, complemented by a formal sex x predictor interaction test. Results: Mid- and late puberty were independently associated with reduced FEV1% and FVC% (beta -0.25 to -0.31), without affecting the FEV1/FVC ratio. Sex-stratified analyses were exploratory and identified apparently divergent predictor sets by sex: in males, the pubertal stage was significant in FEV1% and FVC% (beta -0.30 to -0.42), whereas the BMI z-score diminished the FEV1/FVC ratio (beta = -0.274). In females, FEV1% was associated with HDL-c (beta = 0.463), BMI z-score (beta = 0.429), and ACQ-6 score (beta = -0.306); the female FEV1/FVC% model showed a substantial apparent effect (Cohen's f(2) = 0.508), with ACQ-6 score and HDL-c as primary associated variables. The formal sex x predictor interaction test in the combined sample, however, did not reach statistical significance (DeltaR(2) = 0.037; p = 0.178), indicating that the sex-differential patterns observed in the stratified models were not confirmed as effect modifications. Conclusions: Sex-stratified exploratory analyses in this pediatric asthma cohort identified apparently divergent patterns of associations in males and females; however, the formal interaction test was not statistically significant, indicating that these stratified differences were not confirmed and require validation in adequately powered prospective cohorts. These findings identify HDL-c, body composition, and symptom control as candidate correlates of pulmonary function, with potential sex-related differences warranting further investigation. FAU - Reyes-Noriega, Nayely AU - Reyes-Noriega N AUID- ORCID: 0000-0002-1701-7517 AD - Laboratorio de Investigacion en Alergia e Inmunologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Cuauhtemoc, Mexico City 06720, Mexico. FAU - Leija-Martinez, Jose J AU - Leija-Martinez JJ AUID- ORCID: 0000-0002-7178-1786 AD - Hospital Regional de Alta Especialidad "Dr. Ignacio Morones Prieto", IMSS-Bienestar, Av. Venustiano Carranza No. 2395, San Luis Potosi 78290, Mexico. FAU - Sanchez-Munoz, Fausto AU - Sanchez-Munoz F AUID- ORCID: 0000-0001-6556-1632 AD - Departamento de Fisiologia, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City 14080, Mexico. FAU - Hernandez-Diazcouder, Adrian AU - Hernandez-Diazcouder A AUID- ORCID: 0000-0001-6569-2851 AD - Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico. FAU - Alonso, Claudia Tavera AU - Alonso CT AD - Laboratorio Central, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City 14080, Mexico. FAU - Villafana, Santiago AU - Villafana S AUID- ORCID: 0000-0002-8660-7393 AD - Laboratorio de Terapia Genica Experimental, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico City 11340, Mexico. FAU - Diaz, Dario Jorge Mario Molina AU - Diaz DJMM AD - Departamento de Endocrinologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Cuauhtemoc, Mexico City 06720, Mexico. FAU - Del-Rio-Navarro, Blanca E AU - Del-Rio-Navarro BE AUID- ORCID: 0000-0001-6441-8869 AD - Laboratorio de Investigacion en Alergia e Inmunologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Cuauhtemoc, Mexico City 06720, Mexico. FAU - Huang, Fengyang AU - Huang F AUID- ORCID: 0000-0002-6503-694X AD - Laboratorio de Investigacion en Obesidad y Asma, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. LA - eng GR - HIM/2021/023.SSa. 1748/Federal Government of Mexico/ GR - HIM/2022/044.SSa. 1809/Federal Government of Mexico/ GR - HIM/2023/015 SSa. 1857/Federal Government of Mexico/ GR - HIM/2024/045 SSa. 1943/Federal Government of Mexico/ PT - Journal Article DEP - 20260611 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Male MH - *Asthma/physiopathology/blood MH - *Cholesterol, HDL/blood MH - Cross-Sectional Studies MH - *Body Mass Index MH - *Puberty/physiology MH - Mexico MH - Sex Factors MH - *Lung/physiopathology MH - Respiratory Function Tests MH - Forced Expiratory Volume MH - Vital Capacity PMC - PMC13305537 OTO - NOTNLM OT - FEV1 OT - FVC OT - HDL cholesterol OT - adolescents OT - asthma OT - asthma control OT - children OT - pubertal development OT - sex differences COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/11 CRDT- 2026/06/26 01:17 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - nu18121885 [pii] AID - nutrients-18-01885 [pii] AID - 10.3390/nu18121885 [doi] PST - epublish SO - Nutrients. 2026 Jun 11;18(12):1885. doi: 10.3390/nu18121885. PMID- 42356247 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 9 TI - Food Industry By-Products as Natural Preservatives: Supporting Adolescent Food Literacy and Critical Food Choices. LID - 10.3390/nu18121859 [doi] LID - 1859 AB - This review aims to critically examine food industry by-products as potential sources of natural preservatives and to discuss how this evidence can be translated into adolescent food literacy, label interpretation, and critical food choices. Adolescents are increasingly exposed to food labels and claims about "natural," "clean-label," "upcycled," "sustainable," and "circular" foods, which may not always be transparent or supported by sufficient evidence regarding their safety, efficacy, sensory quality, consumer acceptance, or environmental benefit. Therefore, they need more than nutritional information; they need to interpret labels, question sustainability claims, and understand how food innovations are produced, tested, communicated, and regulated. Food by-products such as fruit and vegetable pomaces, peels, seeds, skins, olive and wine residues, cereal by-products, coffee silverskin, and cocoa residues are promising resources for clean-label preservation and circular food systems because they may contain phenolics, flavonoids, carotenoids, anthocyanins, essential oils, pectin, dietary fibers, and other compounds with antioxidant, antimicrobial, coloring, stabilizing, and texturizing properties. However, the bioactive potential alone does not guarantee that a by-product-derived ingredient is safe, effective, acceptable, scalable, or sustainable. Its use requires extraction, stabilization, real-food validation, safety assessment, sensory optimization, regulatory compliance, and sustainability evaluation. The review concludes that by-product-derived natural preservatives are both technological resources and educational tools. Future research and education should connect food preservation, label interpretation, food safety, sensory quality, sustainability evidence, and consumer decision-making to empower adolescents as critical consumers and informed agents of change in sustainable food systems. FAU - Silva, Paula AU - Silva P AUID- ORCID: 0000-0001-7204-6006 AD - Department of Microscopy, School of Medicine and Biomedical Sciences (ICBAS), University of Porto (U. Porto), Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal. AD - iNOVA Media Lab, ICNOVA-NOVA Institute of Communication, NOVA School of Social Sciences and Humanities, Universidade NOVA de Lisboa, 1069-061 Lisbon, Portugal. LA - eng GR - 10/C06-i07/2024.P11729/European Union/ PT - Journal Article PT - Review DEP - 20260609 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Food Preservatives) SB - IM MH - Humans MH - Adolescent MH - Food Labeling MH - *Food Preservatives MH - *Food Preferences MH - *Food Industry MH - Consumer Behavior MH - Choice Behavior PMC - PMC13304532 OTO - NOTNLM OT - adolescent food literacy OT - circular food systems OT - food industry by-products OT - food labels OT - food waste valorization OT - natural preservatives OT - sustainable food choices COIS- The author declares no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/09 CRDT- 2026/06/26 01:17 PHST- 2026/05/16 00:00 [received] PHST- 2026/06/05 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - nu18121859 [pii] AID - nutrients-18-01859 [pii] AID - 10.3390/nu18121859 [doi] PST - epublish SO - Nutrients. 2026 Jun 9;18(12):1859. doi: 10.3390/nu18121859. PMID- 42356236 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 8 TI - Feasibility and Preliminary Dietary Outcomes of the Smart Family Lifestyle Counseling Intervention in Greek Primary Care: A Single-Arm Pilot Study from Health4Eukids. LID - 10.3390/nu18121848 [doi] LID - 1848 AB - BACKGROUND: Childhood obesity is a complex public health issue in which parental perceptions and family dietary behaviors are pivotal. This study assessed the feasibility of the Smart Family lifestyle counseling intervention in Greek primary care. It explored changes in children's dietary behaviors relative to parental weight perception and Mediterranean diet adherence. METHODS: A single-arm pretest-posttest pilot study was conducted in Patras, Greece, from Health4EUKids Joint Action. The intervention consisted of four monthly face-to-face counseling sessions using the Smart Family methodology. In total, 49 parent-child dyads (aged 2-12 years) completed the program. Data collection included child anthropometric measurements, validated food frequency questionnaires, parental perception of child weight status, and parental Mediterranean diet adherence. RESULTS: Parents who underestimated their child's weight status had significantly higher Mediterranean diet scores than those who overestimated (p = 0.032); those with low adherence tended to overestimate and those with moderate adherence to underestimate. The largest reduction was observed for sweets and desserts (median -2.35 servings/week), with significant reductions in sugar-sweetened beverages, grains and cereals, whole wheat products, and dairy. Fish and vegetable intake increased significantly, but fruit intake did not change. Changes in fast food and red meat differed significantly across Mediterranean diet score tertiles, with larger decreases in the lower tertiles. CONCLUSIONS: Smart Family counseling was feasible to deliver through trained healthcare professionals in Greek primary care over four months, with reductions in selected discretionary foods observed alongside the intervention. Parental weight perception and Mediterranean diet adherence emerged as potential barriers to change although the findings are exploratory and require confirmation in a future controlled trial. FAU - Magriplis, Emmanuella AU - Magriplis E AUID- ORCID: 0000-0001-6517-6857 AD - Laboratory of Dietetics & Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece. AD - Laboratory of Public Health, Epidemiology and Quality of Life, Medical School, University of Patras, 26540 Patras, Greece. FAU - Myrintzou, Niki AU - Myrintzou N AD - Laboratory of Dietetics & Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece. FAU - Desli, Ios-Ioanna AU - Desli II AUID- ORCID: 0009-0005-5221-841X AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Papachatzi, Eleni AU - Papachatzi E AUID- ORCID: 0000-0003-4095-6827 AD - Department of Pediatrics, University General Hospital of Patras, 26504 Patras, Greece. FAU - Vantarakis, Apostolos AU - Vantarakis A AUID- ORCID: 0000-0003-4411-3739 AD - Laboratory of Public Health, Epidemiology and Quality of Life, Medical School, University of Patras, 26540 Patras, Greece. LA - eng GR - 101079944/European Health and Digital Executive Agency/ PT - Journal Article DEP - 20260608 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Pilot Projects MH - Greece MH - Male MH - Female MH - Feasibility Studies MH - Primary Health Care MH - *Counseling/methods MH - Child MH - Diet, Mediterranean MH - Child, Preschool MH - *Pediatric Obesity/prevention & control MH - *Life Style MH - Parents/psychology MH - *Feeding Behavior MH - Adult PMC - PMC13304528 OTO - NOTNLM OT - Mediterranean diet OT - Smart Family OT - childhood obesity OT - dietary behavior OT - family-based intervention OT - feasibility OT - parental perception OT - pilot study OT - primary care COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 07:10 PMCR- 2026/06/08 CRDT- 2026/06/26 01:17 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - nu18121848 [pii] AID - nutrients-18-01848 [pii] AID - 10.3390/nu18121848 [doi] PST - epublish SO - Nutrients. 2026 Jun 8;18(12):1848. doi: 10.3390/nu18121848. PMID- 42356232 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 8 TI - Comparing a 7-Day Food Diary and Repeated 24-Hour Dietary Recall for Estimating Usual and Operational Definitions of Acute Intake in Danish Adults. LID - 10.3390/nu18121845 [doi] LID - 1845 AB - Background: Accurate dietary assessment is essential for estimating habitual and acute exposures. This study compared a 7-day food diary (7dFD) and repeated 24-h dietary recall (2x24hDR) for habitual and acute intake. Habitual fish and n-3 PUFA estimates were evaluated against whole-blood EPA and DHA, and acute intake of fish, rye bread, and coffee was explored using operational indicators. Methods: In a within-subject comparative design, 120 Danish adults aged 18-60 years completed both methods. Fish and n-3 fatty acid intakes were compared with whole-blood EPA and DHA. Usual fish intake from 2x24hDR was estimated using the Multiple Source Method (MSM) with Food Propensity Questionnaire (FPQ) data. Acute intake was assessed using single-day, consumption-day, single-meal, maximum-day, and meal-weighted estimates. Results: EPA, DHA, total fish, and fatty fish intakes estimated from the 7dFD and MSM-adjusted 2x24hDR correlated with biomarkers r = 0.23-0.46. Supplement inclusion improved EPA and DHA correlations (r = 0.26-0.59). The unadjusted 2x24hDR identified fewer fish consumers than the 7dFD (63% vs. 88%), whereas FPQ-based modelling identified 97%. Acute intake estimates varied by method and definition: the 2x24hDR produced higher short-term and upper- percentile estimates, while the 7dFD produced more stable distributions. Limitations include modest sample size, upper-percentile uncertainty, and non-equivalent supplement assessment. Conclusions: In this adult convenience sample, the 7dFD provided more stable habitual intake estimates, whereas the 2x24hDR produced higher short-term and upper-percentile estimates under the applied operational acute-intake definitions. These findings are context-dependent and should not be taken as evidence that either method is generally superior. FAU - Biltoft-Jensen, Anja AU - Biltoft-Jensen A AUID- ORCID: 0000-0002-6607-7575 AD - National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark. FAU - Aristizabal-Henao, Juan J AU - Aristizabal-Henao JJ AUID- ORCID: 0000-0002-2085-2396 AD - BPGbio, BPGbio Inc., Waltham, MA 02451, USA. AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada. FAU - Stark, Ken D AU - Stark KD AUID- ORCID: 0000-0001-7828-4072 AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada. FAU - Christensen, Tue AU - Christensen T AUID- ORCID: 0000-0001-7693-7359 AD - National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260608 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 25167-62-8 (Docosahexaenoic Acids) RN - AAN7QOV9EA (Eicosapentaenoic Acid) RN - 0 (Fatty Acids, Omega-3) SB - IM MH - Humans MH - Adult MH - *Diet Records MH - Middle Aged MH - Male MH - Female MH - Denmark MH - Young Adult MH - Adolescent MH - *Mental Recall MH - *Diet MH - Docosahexaenoic Acids/blood/administration & dosage MH - Fishes MH - Eicosapentaenoic Acid/blood/administration & dosage MH - Seafood MH - Animals MH - Nutrition Assessment MH - *Feeding Behavior MH - Fatty Acids, Omega-3/blood/administration & dosage PMC - PMC13306161 OTO - NOTNLM OT - 24-h dietary recall OT - 7-day food diary OT - DHA OT - EPA OT - acute dietary intake OT - dietary assessment OT - fish intake OT - usual dietary intake OT - validation OT - whole-blood biomarkers COIS- K.S. is on the Board of Directors of the International Society for the Study of Fatty Acids and Lipids (ISSFAL). J.J.A.-H. completed this research at the University of Waterloo during his Ph.D. and currently works for BPGbio Inc., a company that provides lipidomic analyses. The company and the Board of Directors of ISSFAL had no role in the design of the study; in data collection, in analysis, or interpretation; in the writing of the manuscript; or in the decision to publish. A.B. and T.C declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 07:41 PMCR- 2026/06/08 CRDT- 2026/06/26 01:17 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/27 07:41 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - nu18121845 [pii] AID - nutrients-18-01845 [pii] AID - 10.3390/nu18121845 [doi] PST - epublish SO - Nutrients. 2026 Jun 8;18(12):1845. doi: 10.3390/nu18121845. PMID- 42355722 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 12 DP - 2026 Jun 12 TI - Concordance Between Anthropometric Formula Predictions and Chest Radiograph-Confirmed Endotracheal Tube Depth in Young Infants: A Retrospective Cohort Study from Saudi Arabia. LID - 10.3390/jcm15124554 [doi] LID - 4554 AB - Background: Accurate endotracheal tube (ETT) insertion depth is critical in infants and young children, where tracheal malposition carries significant risk. Formula-based depth estimation is widely used at the bedside, but the performance of published formulas in children under two years of age admitted to a general PICU remains poorly characterized. Methods: A retrospective, single-center study was conducted at the PICU of King Saud Medical City, Riyadh. A total of 115 patients aged 1-24 months requiring orotracheal intubation were included. ETT depth was predicted using five established formulas: height-based [(H/10)+5], weight-based [W+6], ETT size-based [ETTx3], Lee weight-based [5.5+0.5W], and Lee height-based [3+0.1H]. Agreement between predicted and radiographically confirmed insertion depth was assessed using Lin's concordance correlation coefficient (CCC), Bland-Altman analysis, and clinical classification of predictions. Results: None of the five formulas achieved acceptable concordance (CCC < 0.75 for all). The height-based formula performed best among published formulas, with negligible bias and the highest proportion of clinically acceptable predictions. Both Lee formulas showed near-universal systematic underestimation and are not suitable for this age group. Over half of all intubations resulted in non-ideal ETT position on the first post-intubation chest X-ray. Novel cohort-derived regression equations outperformed all published formulas, with the weight-based equation (Depth = 0.385 x Weight + 9.145) emerging as the strongest predictor of insertion depth. Conclusions: No published formula achieved reliable concordance with radiographic ETT depth in children aged 1-24 months. The cohort-derived weight-based formula represents a more accurate bedside tool for this population and warrants prospective external validation. Post-intubation radiographic verification remains essential. FAU - Mavrych, Volodymyr AU - Mavrych V AUID- ORCID: 0009-0009-1159-4573 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Majeed, Kashif AU - Majeed K AUID- ORCID: 0009-0007-0870-639X AD - Pediatric Intensive Care Unit, King Saud Medical City, Riyadh 12746, Saudi Arabia. FAU - Alshehri, Saleh AU - Alshehri S AUID- ORCID: 0009-0001-0388-5102 AD - Pediatric Intensive Care Unit, King Saud Medical City, Riyadh 12746, Saudi Arabia. FAU - Yasmin, Uzma AU - Yasmin U AUID- ORCID: 0009-0007-0147-8814 AD - Pediatric Emergency, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Kashif, Muhammad Rayyan AU - Kashif MR AUID- ORCID: 0009-0004-1665-6888 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Kashif, Ayesha AU - Kashif A AUID- ORCID: 0009-0001-6208-2131 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Mahdi, Warda AU - Mahdi W AUID- ORCID: 0009-0006-7040-8222 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Talha, Raghd AU - Talha R AUID- ORCID: 0009-0008-1238-8213 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Bolgova, Olena AU - Bolgova O AUID- ORCID: 0009-0002-9496-9754 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260612 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13301687 OTO - NOTNLM OT - concordance correlation coefficient OT - endotracheal tube OT - insertion depth OT - intensive care OT - pediatric intubation COIS- The authors declare no conflicts of interest, financial or otherwise. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/12 CRDT- 2026/06/26 01:15 PHST- 2026/05/06 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:15 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - jcm15124554 [pii] AID - jcm-15-04554 [pii] AID - 10.3390/jcm15124554 [doi] PST - epublish SO - J Clin Med. 2026 Jun 12;15(12):4554. doi: 10.3390/jcm15124554. PMID- 42355461 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 16 IP - 6 DP - 2026 Jun 1 TI - The Association Between Consumption of Foods/Food Groups and the Risk of Overweight/Obesity and Metabolically Unhealthy Obesity in Children and Adolescents: A Systematic Review and Meta-Analysis. LID - 10.3390/life16060934 [doi] LID - 934 AB - Existing studies have suggested an association between consumption of foods/food groups and the risk of childhood overweight/obesity (OV/OB) and metabolic unhealthy obesity (MUO). However, they are heterogeneous in terms of design, samples and outcomes, and most do not provide evidence of long-term longitudinal associations given their cross-sectional nature. The aim of the present work was to systematically review longitudinal evidence of the association between foods/food groups and the risk of OV/OB and MUO in children and adolescents aged 2-19 years. Two databases (Scopus and PubMed) were searched for original research conducted in Western countries. Prospective epidemiological studies (PES) and randomized controlled trials (RCTs) with exposures/interventions related to the consumption of foods/food groups, OV/OB- or MUO-related outcomes and >/=1-year follow-up were considered eligible. A narrative evidence synthesis, complemented by random-effects meta-analyses where feasible, was performed. The review protocol was registered in PROSPERO (ID: CRD42024496148). The narrative synthesis of 23 longitudinal studies revealed a detrimental effect of sugar-sweetened beverages (SSBs) (n = 8/10 PESs and 1/2 RCTs) and ultra-processed foods (UPFs) (n = 2/3 PESs), and a beneficial effect of full/higher-fat dairy products (n = 2/3 PESs) on OV/OB-related outcomes, although certainty in evidence was (very) low. Evidence was inconclusive for artificially sweetened beverages, fruits and vegetables (primarily 100% fruit juices), milk and total dairy products. Random-effects meta-analysis of PESs focusing on SSBs revealed a positive association with follow-up body mass index (n = 3, pooled beta: 0.16 kg/m(2), 95%CI: 0.09, 0.23) but a non-significant association with change in BMI (n = 3, pooled beta: 0.07 kg/m(2), 95%CI: -0.05, 0.19). Only 1 PES reported on MUO-related outcomes and revealed a potential beneficial link between higher-fat milk intake and selected cardiometabolic indices. In conclusion, consumption of SSBs is positively associated with indicators of childhood OV/OB risk. A detrimental effect of UPFs and a beneficial effect of higher-fat dairy products on childhood adiposity outcomes were also observed, but the available evidence remains limited and insufficient to draw robust conclusions. Data for other foods/food groups and OV/OB, as well as for their link with childhood MUO, remain scarce and inconclusive. FAU - Bature, Fidelia AU - Bature F AD - Institute for Health Research, Putteridge Bury Campus, University of Bedfordshire, Luton LU28LE, UK. FAU - Georgoulis, Michael AU - Georgoulis M AUID- ORCID: 0000-0003-4619-2100 AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 17676 Athens, Greece. FAU - Kyrkili, Athanasia AU - Kyrkili A AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 17676 Athens, Greece. FAU - Kontogianni, Meropi D AU - Kontogianni MD AUID- ORCID: 0000-0003-3168-8867 AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 17676 Athens, Greece. FAU - Koti, Zoi-Eleni AU - Koti ZE AD - Ukemed Global Ltd. 121, Prodromou Street Offices 713-715, 2064 Nicosia, Cyprus. FAU - Kapsala, Chara AU - Kapsala C AD - Ukemed Global Ltd. 121, Prodromou Street Offices 713-715, 2064 Nicosia, Cyprus. FAU - Korma, Iliana AU - Korma I AD - Ukemed Global Ltd. 121, Prodromou Street Offices 713-715, 2064 Nicosia, Cyprus. FAU - Pappas, Yannis AU - Pappas Y AUID- ORCID: 0000-0003-3087-860X AD - Institute for Health Research, Putteridge Bury Campus, University of Bedfordshire, Luton LU28LE, UK. LA - eng GR - No 101080718/the European Union's HORIZON 2022 research and innovation program/ PT - Journal Article PT - Review DEP - 20260601 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC13302376 OTO - NOTNLM OT - children OT - food groups OT - foods OT - obesity OT - overweight OT - systematic review COIS- Authors Zoi-Eleni Koti, Chara Kapsala and Iliana Korma were employed by the company UKEMED GLOBAL LtD. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/01 CRDT- 2026/06/26 01:14 PHST- 2026/02/14 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:14 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - life16060934 [pii] AID - life-16-00934 [pii] AID - 10.3390/life16060934 [doi] PST - epublish SO - Life (Basel). 2026 Jun 1;16(6):934. doi: 10.3390/life16060934. PMID- 42355398 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 16 IP - 6 DP - 2026 May 22 TI - The Mediating Effect of Physical Fitness on the Relationship Between Developmental Coordination Disorder and Physical Activity in School-Aged Children-An Observational Study. LID - 10.3390/life16060870 [doi] LID - 870 AB - Evidence remains limited on the interconnections between developmental coordination disorder (DCD), health-related physical fitness-including body composition, flexibility, strength of lower body, and cardiorespiratory fitness-and objectively measured physical activity (PA) in school-aged children. This study aimed to (1) examine differences in physical fitness and PA between children with and without DCD and (2) investigate whether physical fitness functions as a mediator in the association between DCD and PA in school-aged children. Sixty-three children aged 6.5-8 years (12 DCD, 19.05%) who provided valid data were enrolled. Mediation analysis was conducted using the PROCESS macro for SPSS. Flexibility significantly mediates the relationship of DCD to vigorous PA (VPA) (effect = 3.202, bootstrap SE = 1.682, 95% bootstrap CI = 0.463, 7.078), as well as DCD to moderate-to-vigorous (MVPA) (effect = 5.194, bootstrap SE = 2.903, 95% bootstrap CI = 0.434, 11.778). Additionally, there was a significant mediating effect of lower muscle strength on the relationship between DCD and VPA (effect = -1.943, bootstrap SE = 1.297, 95% bootstrap CI = -5.112, -0.021), and DCD and counts per minute (CPM) in axis 2 (effect = -34.388, bootstrap SE = 20.212, 95% bootstrap CI = -80.819, -1.353). The findings highlight flexibility and lower-body strength as potential mechanisms underlying the association between DCD and PA participation. These factors may represent candidate intervention targets; however, their roles require confirmation in larger samples and longitudinal designs. FAU - Tran, Huynh-Truc AU - Tran HT AUID- ORCID: 0000-0002-2077-2150 AD - Department of Public Health, China Medical University, Taichung 406040, Taiwan. FAU - Ho, Wen-Chao AU - Ho WC AUID- ORCID: 0000-0002-6095-3335 AD - Department of Public Health, China Medical University, Taichung 406040, Taiwan. FAU - Chou, Li-Wei AU - Chou LW AUID- ORCID: 0000-0002-3540-6225 AD - Department of Physical Therapy and Graduate Institute of Rehabilitation Science, China Medical University, Taichung 406040, Taiwan. AD - Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung 404332, Taiwan. AD - Department of Physical Medicine and Rehabilitation, Asia University Hospital, Asia University, Taichung 413505, Taiwan. FAU - Li, Yao-Chuen AU - Li YC AUID- ORCID: 0000-0002-9156-4033 AD - Department of Physical Therapy and Graduate Institute of Rehabilitation Science, China Medical University, Taichung 406040, Taiwan. AD - Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung 404332, Taiwan. LA - eng GR - NSTC 112-2410-H-039-006-MY2/National Science and Technology Council/ GR - CMU112-MF-95/China Medical University/ PT - Journal Article DEP - 20260522 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC13302645 OTO - NOTNLM OT - accelerometry OT - developmental coordination disorder OT - flexibility OT - lower-body strength OT - mediation OT - physical activity COIS- The authors reported no conflicts of interest. EDAT- 2026/06/26 06:39 MHDA- 2026/06/26 06:40 PMCR- 2026/05/22 CRDT- 2026/06/26 01:14 PHST- 2026/04/05 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/26 06:40 [medline] PHST- 2026/06/26 06:39 [pubmed] PHST- 2026/06/26 01:14 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - life16060870 [pii] AID - life-16-00870 [pii] AID - 10.3390/life16060870 [doi] PST - epublish SO - Life (Basel). 2026 May 22;16(6):870. doi: 10.3390/life16060870. PMID- 42354613 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 12 DP - 2026 Jun 18 TI - Early Postpartum Milk-Expression and Expressed-Milk Feeding Practices in Relation to Breastfeeding Outcomes: A Systematic Review. LID - 10.3390/healthcare14121755 [doi] LID - 1755 AB - Background/Objectives: Early postpartum milk expression is common, but its relationship with later breastfeeding outcomes depends on the clinical context in which expression is used. This systematic review examined distinct exposure domains, including expression method, timing and intensity of expression, expressed-milk feeding modality, composite in-hospital feeding patterns, and clinically indicated expression in pump-dependent populations. Methods: Following PRISMA 2020 guidance, primary studies of postpartum milk expression, breast pump use, or expressed breast-milk feeding were identified and synthesized using a PECO framework. Because included studies differed substantially in population, exposure definition, comparator structure, and outcome measurement, meta-analysis was not undertaken. Instead, studies were grouped a priori into exposure families, and conclusions were derived within each domain while explicitly considering risk of bias was assessed using RoB 2, version of 22 August 2019, for randomized trials and the original 2016 version of ROBINS-I for non-randomized studies. Results: Seventeen studies met the eligibility criteria. In healthy term dyads, routine early pumping or exclusive/predominant expressed-milk feeding was generally associated with less favorable breastfeeding continuation than direct feeding at the breast, although these associations were mainly derived from observational studies at serious risk of confounding by indication. In preterm, separated, or otherwise pump-dependent dyads, earlier and more frequent milk expression was associated with improved early lactation outcomes, including lactogenesis, milk yield, or achievement of full lactation; evidence for longer-term breastfeeding continuation was more limited. Broad population-level definitions of any pump use produced less consistent findings and were not directly comparable with studies of exclusive expressed-milk feeding. Conclusions: Early postpartum milk expression should be interpreted as a context-dependent practice rather than as a uniform exposure. The strongest clinical inference is that direct breastfeeding should be supported when feasible in healthy term dyads, whereas early and frequent expression remains necessary and potentially beneficial when direct breastfeeding is not immediately possible. FAU - Dagla, Maria AU - Dagla M AUID- ORCID: 0000-0003-4871-999X AD - Laboratory of Midwifery Care During Antenatal and Post Natal Period-Breastfeeding, Department of Midwifery, School of Health & Care Sciences, University of West Attica, 12243 Athens, Greece. FAU - Brani, Panagiota AU - Brani P AD - Laboratory of Midwifery Care During Antenatal and Post Natal Period-Breastfeeding, Department of Midwifery, School of Health & Care Sciences, University of West Attica, 12243 Athens, Greece. FAU - Dagla, Calliope AU - Dagla C AD - Laboratory of Midwifery Care During Antenatal and Post Natal Period-Breastfeeding, Department of Midwifery, School of Health & Care Sciences, University of West Attica, 12243 Athens, Greece. FAU - Tsolaridou, Eleni AU - Tsolaridou E AD - Laboratory of Midwifery Care During Antenatal and Post Natal Period-Breastfeeding, Department of Midwifery, School of Health & Care Sciences, University of West Attica, 12243 Athens, Greece. FAU - Louverdi, Sevasti AU - Louverdi S AD - Laboratory of Midwifery Care During Antenatal and Post Natal Period-Breastfeeding, Department of Midwifery, School of Health & Care Sciences, University of West Attica, 12243 Athens, Greece. FAU - Antoniou, Evangelia AU - Antoniou E AUID- ORCID: 0000-0003-4494-3089 AD - Laboratory of Midwifery Care During Antenatal and Post Natal Period-Breastfeeding, Department of Midwifery, School of Health & Care Sciences, University of West Attica, 12243 Athens, Greece. FAU - Tomara, Eirini AU - Tomara E AD - Laboratory of Midwifery Care During Antenatal and Post Natal Period-Breastfeeding, Department of Midwifery, School of Health & Care Sciences, University of West Attica, 12243 Athens, Greece. LA - eng PT - Journal Article PT - Review DEP - 20260618 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13299557 OTO - NOTNLM OT - breast milk expression OT - breast pump use OT - breastfeeding duration OT - breastfeeding outcomes OT - early postpartum period OT - exclusive breastfeeding OT - expressed breast milk feeding OT - lactation OT - maternal-infant feeding practices OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 10:10 MHDA- 2026/06/26 10:11 PMCR- 2026/06/18 CRDT- 2026/06/26 01:11 PHST- 2026/03/30 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/26 10:11 [medline] PHST- 2026/06/26 10:10 [pubmed] PHST- 2026/06/26 01:11 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - healthcare14121755 [pii] AID - healthcare-14-01755 [pii] AID - 10.3390/healthcare14121755 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jun 18;14(12):1755. doi: 10.3390/healthcare14121755. PMID- 42354482 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 12 DP - 2026 Jun 9 TI - Climate Change Worry and Flourishing Among Chinese University Students: The Roles of Anxiety-Depressive Symptoms and Physical Activity. LID - 10.3390/healthcare14121624 [doi] LID - 1624 AB - Background/Objectives: Climate change worry is an emerging concern in youth mental health, but little is known about how it is associated with positive psychological functioning among university students. This study examined whether climate change worry was associated with flourishing and whether this association showed a cross-sectional statistical indirect effect through anxiety and depressive symptoms, with physical activity specified as a first-stage boundary condition. Methods: A cross-sectional anonymous survey was conducted in 2026 using convenience sampling among students from four universities located in three provincial-level regions of China, covering southern, western, and central areas. After predefined quality control procedures, 2826 valid responses were included. Climate change worry, anxiety and depressive symptoms, flourishing, and physical activity were assessed using the Climate Change Worry Scale (CCWS), the Patient Health Questionnaire-4 (PHQ-4), the Flourishing Scale (FS), and the Physical Activity Rating Scale-3 (PARS-3), respectively. Pearson correlations and conditional process analyses were conducted using the PROCESS macro, with 5000 bootstrap samples. Results: Climate change worry was positively associated with anxiety and depressive symptoms (r = 0.331, p < 0.001) and negatively associated with flourishing (r = -0.193, p < 0.001). Anxiety and depressive symptoms were negatively associated with flourishing (r = -0.486, p < 0.001). The cross-sectional statistical indirect effect through anxiety and depressive symptoms was significant (indirect effect = -0.1277, 95% bootstrap CI: [-0.1441, -0.1123]). Physical activity was statistically associated with a weaker first-stage association between climate change worry and anxiety/depressive symptoms (B = -0.0014, p < 0.001; DeltaR(2) = 0.0064). The index of moderated mediation was significant (0.0014, 95% bootstrap CI: [0.0008, 0.0020]). Conclusions: Climate change worry was statistically associated with lower flourishing, primarily through higher anxiety and depressive symptoms. Physical activity was associated with a weaker first-stage association, but the moderation effect was small in practical magnitude. Given the cross-sectional and self-report design, these findings should be interpreted as conditional statistical associations rather than causal or protective effects. FAU - Liu, Shiqi AU - Liu S AD - School of Physical Education, Xinjiang Normal University, Urumqi 830017, China. FAU - Tan, Yanli AU - Tan Y AD - School of Physical Education, Xinjiang Normal University, Urumqi 830017, China. FAU - Zang, Liuhong AU - Zang L AD - School of Physical Education, Xinjiang Normal University, Urumqi 830017, China. LA - eng GR - 2025BTY153./Xinjiang Normal University/ PT - Journal Article DEP - 20260609 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13299314 OTO - NOTNLM OT - anxiety and depressive symptoms OT - climate change worry OT - conditional process analysis OT - flourishing OT - physical activity OT - university students COIS- The authors declare no conflicts of interest. The funder had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/26 06:40 MHDA- 2026/06/26 06:41 PMCR- 2026/06/09 CRDT- 2026/06/26 01:11 PHST- 2026/04/29 00:00 [received] PHST- 2026/05/23 00:00 [revised] PHST- 2026/05/24 00:00 [accepted] PHST- 2026/06/26 06:41 [medline] PHST- 2026/06/26 06:40 [pubmed] PHST- 2026/06/26 01:11 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - healthcare14121624 [pii] AID - healthcare-14-01624 [pii] AID - 10.3390/healthcare14121624 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jun 9;14(12):1624. doi: 10.3390/healthcare14121624. PMID- 42354349 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20261020 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 Jun 20 TI - Physical Activity of University Students During COVID-19 Restrictions: Evidence from Poland. LID - 10.3390/ijerph23060820 [doi] LID - 820 AB - This study aims to empirically analyze the patterns, intensity, and perceived barriers to physical activity among Polish university students during the COVID-19 pandemic. The research utilized a diagnostic survey method, employing a questionnaire. The online survey was conducted from December 2020 to May 2022 via the Webankieta.pl platform. The minimum sample size, calculated using the standard formula for estimating a proportion in a large population, was set at 1100 participants and was exceeded, with 1260 students providing valid responses. The results show that over half (55.8%, mainly women) of the respondents did not participate in regular physical activity during the pandemic. Participants cited lack of desire, fatigue, and low motivation-not pandemic restrictions-as primary reasons. Conversely, 44.2% of respondents, mostly men, reported engaging in regular physical activity. Most engaged in moderate-intensity activities two to five times a week, with vigorous activities performed slightly less often. Women were more likely to do both types, while men favored strength training. The most common activities included walking (61.6%), simple gymnastic exercises (43.1%), strength training with equipment (35.0%), cycling (34.5%), and calisthenics (30.2%). The majority (81.3%) exercised at home or nearby (33.4%). Reported barriers, especially among those who exercised regularly, were pandemic-related, such as limited or closed access to gyms, fitness centers, and pools (59.1%), along with time constraints (44.7%) and low motivation or determination (32.0%). The findings emphasize the importance of targeted interventions to boost physical activity among university students, particularly women and those with fewer financial resources. Universities should consider implementing programs that promote accessible, regular activity and initiatives to enhance motivation and foster long-term, health-promoting habits. FAU - Gabryjonczyk, Piotr AU - Gabryjonczyk P AUID- ORCID: 0000-0002-8815-9723 AD - Institute of Economics and Finance, Warsaw University of Life Sciences-SGGW, 02-787 Warsaw, Poland. FAU - Jeczmyk, Anna AU - Jeczmyk A AUID- ORCID: 0000-0001-7863-2217 AD - Faculty of Economics, Poznan University of Life Sciences, 60-637 Poznan, Poland. FAU - Wojcieszak-Zbierska, Monika AU - Wojcieszak-Zbierska M AUID- ORCID: 0000-0002-9962-2648 AD - Faculty of Economics, Poznan University of Life Sciences, 60-637 Poznan, Poland. FAU - Uglis, Jaroslaw AU - Uglis J AUID- ORCID: 0000-0001-6653-2745 AD - Faculty of Economics, Poznan University of Life Sciences, 60-637 Poznan, Poland. FAU - Zawadka, Jan AU - Zawadka J AUID- ORCID: 0000-0003-1979-0607 AD - Institute of Economics and Finance, Warsaw University of Life Sciences-SGGW, 02-787 Warsaw, Poland. LA - eng PT - Journal Article DEP - 20260620 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Poland/epidemiology MH - *Students/statistics & numerical data/psychology MH - Universities MH - *COVID-19/epidemiology/prevention & control MH - Male MH - Female MH - *Exercise MH - Young Adult MH - Adult MH - Surveys and Questionnaires MH - Motivation MH - SARS-CoV-2 MH - Adolescent PMC - PMC13300500 OTO - NOTNLM OT - COVID-19 OT - Polish university students OT - pandemic OT - physical activity OT - physical effort COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 04:10 PMCR- 2026/06/20 CRDT- 2026/06/26 01:10 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/23 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - ijerph23060820 [pii] AID - ijerph-23-00820 [pii] AID - 10.3390/ijerph23060820 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Jun 20;23(6):820. doi: 10.3390/ijerph23060820. PMID- 42354335 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20261024 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 Jun 17 TI - Association Between Physical Activity, Body Mass Index, and Aerobic Capacity in Periurban Adolescents. LID - 10.3390/ijerph23060806 [doi] LID - 806 AB - Adolescence is a critical window for health behavior consolidation, yet the combined influence of physical activity level (PAL) and the body mass index (BMI) on aerobic capacity remains understudied, especially in transitioning periurban environments. This study examined the association between PAL, BMI, and aerobic capacity in adolescents from Monteria, Colombia. A cross-sectional study was conducted among 112 adolescents (aged 12-17 years). Aerobic capacity was assessed using the 20 m shuttle run test (Course Navette), and PAL was measured via the validated Assessment of Physical Activity Levels Questionnaire (APALQ), following standard fitness assessment protocols. Multivariable linear regression models were utilized to estimate independent associations, adjusting for age and sex. The multivariable model was significant (F = 8.45; p < 0.001), explaining 21% of the variance in aerobic capacity (adjusted R(2) = 0.21). PAL was positively and independently associated with aerobic capacity (B = 0.22; 95% CI: 0.05-0.38; p = 0.010), regardless of BMI. While age showed a positive association (B = 0.09; p = 0.032) and sex was inversely associated (B = -0.39; p < 0.001), BMI did not emerge as an independent predictor in the adjusted model (B = -0.04; p = 0.080). Aerobic capacity in adolescents is more consistently explained by behavioral factors (what they "do") than by anthropometric status (what they "weigh"). These findings support a paradigm shift in pediatric public health, prioritizing high-intensity movement overweight control to improve cardiorespiratory fitness in transitioning urban territories. FAU - Sepulveda, Fabian AU - Sepulveda F AUID- ORCID: 0000-0002-2715-3184 AD - Programa de Maestria en Epidemiologia de la, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. FAU - Penata-Taborda, Ana AU - Penata-Taborda A AUID- ORCID: 0000-0001-8698-612X AD - Grupo de Investigacion Biomedica y Biologia Molecular, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. FAU - Bru-Cordero, Osnamir AU - Bru-Cordero O AUID- ORCID: 0000-0001-9425-9475 AD - Direccion Academica, Universidad Nacional de Colombia Sede de La Paz, Cesar 200017, Colombia. FAU - Montoya-Alvarez, Leily AU - Montoya-Alvarez L AUID- ORCID: 0000-0002-3806-7986 AD - Grupo de Investigacion MOSABI, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. FAU - Humanez-Alvarez, Alicia AU - Humanez-Alvarez A AUID- ORCID: 0000-0002-3114-6235 AD - Grupo de Investigacion Biomedica y Biologia Molecular, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Body Mass Index MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - *Exercise MH - Colombia MH - *Cardiorespiratory Fitness MH - *Physical Fitness PMC - PMC13299683 OTO - NOTNLM OT - behavioral determinants and multivariable analysis OT - cardiorespiratory fitness OT - nutritional status OT - periurban health COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; the collection, analyses, or interpretation of data; the writing of the manuscript; or the decision to publish the results. EDAT- 2026/06/26 13:10 MHDA- 2026/06/27 04:10 PMCR- 2026/06/17 CRDT- 2026/06/26 01:10 PHST- 2025/12/15 00:00 [received] PHST- 2026/03/02 00:00 [revised] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - ijerph23060806 [pii] AID - ijerph-23-00806 [pii] AID - 10.3390/ijerph23060806 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Jun 17;23(6):806. doi: 10.3390/ijerph23060806. PMID- 42354263 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 May 30 TI - Psychological Distress and Associated Factors Among High-School Students in Makkah, Saudi Arabia: A Cross-Sectional Study Using the Arabic GHQ-30. LID - 10.3390/ijerph23060733 [doi] LID - 733 AB - BACKGROUND: Mental health problems often begin in adolescence, yet early detection and intervention remain limited. This study assesses the prevalence of psychological distress and its correlates among high-school students in Makkah, Saudi Arabia, and explores whether specific symptom clusters of depression, anxiety and bipolar/mania can be identified using the General Health Questionnaire-30 (GHQ-30). METHODS: A cross-sectional survey was conducted during the 2025-2026 academic year using stratified cluster sampling. A total of 535 students aged 15-18 years completed a questionnaire containing the validated Arabic GHQ-30 and demographic, socioeconomic and lifestyle items. The GHQ-30 was scored with binary 0-0-1-1 scoring (cut-off >/= 6) to define cases of psychological distress. Item clusters were used to screen for probable depression, anxiety and bipolar/mania. Descriptive statistics characterized the sample. Associations were examined using chi-square tests and multivariable logistic regression. RESULTS: Overall, 70.5% of participants screened positive for psychological distress. The prevalences of probable depression, anxiety and bipolar/mania were 33.1%, 28.2% and 31.2%, respectively. In adjusted models, female gender, insufficient sleep, lack of physical activity and exposure to bullying were associated with increased odds of psychological distress; longer sleep was protective. History of mental health conditions was a strong predictor of probable depression, whereas medication use was protective. Older age and higher paternal education were protective for anxiety. Bullying was the most consistent predictor across all symptom clusters. CONCLUSIONS: Psychological distress is highly prevalent among Makkah high-school students. Key determinants include gender, sleep duration, lack of physical activity and bullying. Routine school-based mental health screening, sleep-hygiene education, anti-bullying initiatives and early referral pathways are warranted. Further research should examine and validate GHQ-30 item clusters for specific disorders. FAU - Hashim, Arwa Hesham AU - Hashim AH AD - Saudi Board Program of Preventive Medicine, Program, Makkah Health Cluster, Makkah 24242, Saudi Arabia. FAU - Khan, Adeel Ahmed AU - Khan AA AUID- ORCID: 0000-0003-2724-8113 AD - Saudi Board Program of Preventive Medicine, Program, Makkah Health Cluster, Makkah 24242, Saudi Arabia. FAU - Hayat, Aalia Akhtar AU - Hayat AA AUID- ORCID: 0000-0001-6609-0879 AD - Department of Child Psychiatry, Maternity and Children Hospital, Makkah Health Cluster, Makkah 24242, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260530 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - *Students/psychology/statistics & numerical data MH - Male MH - *Psychological Distress MH - Surveys and Questionnaires MH - Prevalence MH - *Stress, Psychological/epidemiology MH - Depression/epidemiology PMC - PMC13299696 OTO - NOTNLM OT - GHQ-30 OT - Saudi Arabia OT - adolescent mental health OT - bullying OT - cross-sectional study OT - high-school students OT - physical activity OT - psychological distress OT - school-based screening OT - sleep duration COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 07:10 PMCR- 2026/05/30 CRDT- 2026/06/26 01:10 PHST- 2026/04/20 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - ijerph23060733 [pii] AID - ijerph-23-00733 [pii] AID - 10.3390/ijerph23060733 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 May 30;23(6):733. doi: 10.3390/ijerph23060733. PMID- 42354229 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 May 25 TI - Prevalence, Risk Factors, and Preventive Strategies of Hypertension Among Young Adults in the United Arab Emirates. LID - 10.3390/ijerph23060698 [doi] LID - 698 AB - Background: Hypertension is one of the most common noncommunicable diseases. Objectives: This research assessed the magnitude of hypertension among young adults, identified its key determinants, and explored potential strategies adopted for prevention. Methods: A cross-sectional design was employed, including 1606 participants aged 18 years and older, recruited through convenience sampling from universities and community settings. Data were collected using a content-validated questionnaire covering sociodemographic information, personal and family medical history, and lifestyle habits. Results: Of the participants, 993 (61.8%) reported hypertension, nearly double previous national estimates. Male gender, age >/= 30 years, and family history were significant risk factors, along with smoking, alcohol use, sedentary lifestyle, and unhealthy diet, while physical activity and dietary modification were protective. Despite high prevalence, only 22.1% had controlled blood pressure and 17.8% adhered to medication, with 51.5% relying on herbal remedies. Conclusions: These findings highlight the urgent need for early screening, youth-focused awareness, and culturally tailored interventions to reduce hypertension and prevent long-term cardiovascular complications. Hypertension among young adults in the UAE is a major public health concern, requiring integrated strategies combining education, lifestyle modification, and medical management to improve outcomes. FAU - Raid Hussain Aljubori, Aws AU - Raid Hussain Aljubori A AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Abutartour, Mahmoud Nabil M AU - Abutartour MNM AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Abdulla Darwish Ali, Ibrahim AU - Abdulla Darwish Ali I AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Ghaith Al Haj Younes, Mohammed AU - Ghaith Al Haj Younes M AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Muttappallymyalil, Jayakumary AU - Muttappallymyalil J AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. LA - eng PT - Journal Article DEP - 20260525 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Hypertension/epidemiology/prevention & control/etiology MH - Male MH - Female MH - Risk Factors MH - United Arab Emirates/epidemiology MH - Prevalence MH - Young Adult MH - Cross-Sectional Studies MH - Adult MH - Adolescent MH - Life Style MH - Surveys and Questionnaires PMC - PMC13299299 OTO - NOTNLM OT - UAE OT - hypertension OT - prevalence OT - preventive practices OT - young adults COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 04:10 PMCR- 2026/05/25 CRDT- 2026/06/26 01:10 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - ijerph23060698 [pii] AID - ijerph-23-00698 [pii] AID - 10.3390/ijerph23060698 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 May 25;23(6):698. doi: 10.3390/ijerph23060698. PMID- 42354070 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 12 DP - 2026 Jun 11 TI - Aflatoxin M1 in Milk from South-Central and Northwest China: Prevalence and Integrated Risk Characterization for Different Age-Sex Groups of Consumers. LID - 10.3390/foods15122102 [doi] LID - 2102 AB - Aflatoxin M1 (AFM1) is a Group 1 human carcinogen that poses a public health risk through milk contamination. This study investigated AFM1 contamination in pasteurized and ultra-high temperature (UHT) milk from south-central and northwest China, and assessed the associated health risks for consumers based on age, sex, and milk consumption scenarios. In total, 902 milk samples (493 pasteurized, 409 UHT) were collected during the summer and winter seasons of 2023-2024. AFM1 levels were determined using a validated enzyme-linked immunosorbent assay. AFM1 was detected in 75.39% of samples (mean concentration, 12.35 +/- 10.27 ng/L; maximum, 75.57 ng/L). While 1.55% of samples exceeded the EU maximum limit (50 ng/L), all complied with the Chinese limit (500 ng/L). Contamination was significantly higher in south-central China than northwest China, higher in winter than summer, and higher in pasteurized milk than UHT milk (p < 0.05). Preschool children in south-central China consuming 400 mL/day of milk are the group with the highest AFM11 exposure risk. And the margin of exposure and population risk of liver cancer suggested little carcinogenic risk. Therefore, targeted monitoring strategies for AFM1 in milk are recommended, along with dietary guidance for high-risk groups, especially vulnerable young children, to mitigate exposure. FAU - Zhang, Xue AU - Zhang X AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Zhang, Ting AU - Zhang T AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Zhang, Jie AU - Zhang J AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Qiu, Yinsheng AU - Qiu Y AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Lu, Qirong AU - Lu Q AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Xiong, Jianglin AU - Xiong J AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Wang, Chong AU - Wang C AUID- ORCID: 0000-0003-2770-4836 AD - Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, China. LA - eng GR - 2025C04036/Zhejiang Provincial Science and Technology Plan Project/ GR - 2025ZDXT15-03/Zhejiang Animal Husbandry Industry Technology Project and Cooperative Extension Plan of Major Agricultural Technologies of Zhejiang Province/ GR - 2026SNJF067/Science and Technology Cooperation Plan of "SanNongJiuFang" of Zhejiang Province/ GR - K2024-1-1-17, K2024-1-1-18, K2024-1-1-19/Jiaxing Commissioner Project/ PT - Journal Article DEP - 20260611 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13298350 OTO - NOTNLM OT - China OT - aflatoxin M1 OT - milk OT - prevalence OT - risk characterization COIS- The authors declare that there is no conflict of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/26 16:11 PMCR- 2026/06/11 CRDT- 2026/06/26 01:09 PHST- 2026/05/09 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/26 16:11 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - foods15122102 [pii] AID - foods-15-02102 [pii] AID - 10.3390/foods15122102 [doi] PST - epublish SO - Foods. 2026 Jun 11;15(12):2102. doi: 10.3390/foods15122102. PMID- 42353998 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 6 DP - 2026 Jun 18 TI - Gut Microbiome Responses to Nutritional and Lifestyle Interventions in Pediatric Obesity: A Systematic Review Toward Precision Nutrition. LID - 10.3390/children13060828 [doi] LID - 828 AB - Background: Childhood obesity is increasingly associated with gut microbiome dysbiosis. This systematic review (PROSPERO CRD420251131354) evaluates evidence from studies published between 2020 and 2026 assessing how nutritional and lifestyle interventions influence gut microbiota in children with obesity. Methods: A systematic search of PubMed, EMBASE and EBSCO identified 21 interventional studies involving children aged 5-18 years with obesity, with the last search conducted in April 2026. Interventions comprised prebiotics, probiotics, synbiotics, postbiotics, high-fiber diets, calorie-restricted dietary approaches, and lifestyle modifications such as physical activity. Microbiome outcomes were analyzed using 16S rRNA sequencing, quantitative real-time polymerase chain reaction (qPCR), or metagenomics. Risk of bias was evaluated using the RoB 2 and ROBINS-I (version 2) tools. Due to substantial heterogeneity in study design, participant characteristics, intervention types, and analytical methods, a meta-analysis was not feasible. Results: Across 21 studies, nutritional interventions included measurable but heterogeneous alterations in gut microbiome composition. Inulin supplementation was associated with a significant increase in alpha diversity and with higher relative abundances of Bifidobacterium, Blautia, Megasphaera, Subdoligranulum, and Eubacterium coprostanoligenes. Synbiotic supplementation increased Prevotella and Dialister and reduced the Firmicutes/Bacteroidetes ratio. High-fiber dietary interventions increased Faecalibacterium, Bifidobacterium, and Clostridium, while reducing Bacteroides, and were associated with shifts in metabolic pathways related to carbohydrate, lipid, and nucleotide metabolism. Calorie-restricted diets and combined diet-exercise interventions increased beneficial taxa such as Akkermansia muciniphila, improved microbial diversity, and correlated with favorable metabolic and anthropometric outcomes. Overall, nutritional and lifestyle interventions in pediatric obesity were associated with taxon-specific and context-dependent microbiome changes, rather than uniform restructuring. Conclusions: Nutritional interventions can modulate gut microbiota diversity, composition, and predicted function in pediatric obesity; however, the observed effects vary substantially across studies. The limited number of trials, small sample sizes, and methodological heterogeneity underscore the need for larger, standardized studies to better define clinical and therapeutic implications. FAU - Margasoiu, Iuliana AU - Margasoiu I AUID- ORCID: 0009-0004-4944-1445 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Pinzariu, Alin Constantin AU - Pinzariu AC AUID- ORCID: 0000-0001-5730-1662 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Manole, Lorena Mihaela AU - Manole LM AUID- ORCID: 0009-0003-6798-9984 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Spoiala, Elena-Lia AU - Spoiala EL AUID- ORCID: 0000-0002-7015-0085 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Paduraru, Gabriela AU - Paduraru G AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Ghiga, Gabriela AU - Ghiga G AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Popa, Irene Paula AU - Popa IP AUID- ORCID: 0009-0009-6543-1454 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Serban, Dragomir Nicolae AU - Serban DN AUID- ORCID: 0000-0001-6642-105X AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Serban, Ionela Lacramioara AU - Serban IL AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Trandafir, Laura Mihaela AU - Trandafir LM AUID- ORCID: 0000-0002-8326-7610 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. LA - eng GR - SMIS code 351058/Grigore T. Popa University of Medicine and Pharmacy/ PT - Journal Article PT - Review DEP - 20260618 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13297285 OTO - NOTNLM OT - children OT - dietary intervention OT - gut microbiota OT - lifestyle intervention OT - obesity OT - physical activity OT - postbiotic OT - prebiotic OT - probiotic OT - synbiotic COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/18 CRDT- 2026/06/26 01:09 PHST- 2026/05/15 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - children13060828 [pii] AID - children-13-00828 [pii] AID - 10.3390/children13060828 [doi] PST - epublish SO - Children (Basel). 2026 Jun 18;13(6):828. doi: 10.3390/children13060828. PMID- 42353995 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 6 DP - 2026 Jun 17 TI - Physical Activity as a Mediator of the Relationship Between Mediterranean Diet Adherence and Anxiety Symptoms in Chilean Adolescents: A Cross-Sectional Study. LID - 10.3390/children13060825 [doi] LID - 825 AB - BACKGROUND: Adolescent mental health is a global concern, with lifestyle factors such as diet and physical activity (PA) playing a crucial role. While the Mediterranean Diet adherence (MDA) is known for its neuroprotective benefits on mental health, the mechanisms by which they are related remain unclear. Therefore, the aim of this study was twofold: (1) to examine the associations between MDA, PA, and screen time (ST) with anxiety symptoms, depression, stress, and total psychological distress in Chilean adolescents; and (2) to determine whether PA mediates the relationship between MDA and anxiety symptoms. METHODS: A cross-sectional study was conducted with 322 Chilean school-aged adolescents 158 males and 164 females (14.98 +/- 1.96 years). Mental health outcomes (depression, anxiety, and stress) and lifestyle behaviors, including MDA, PA, and ST, were comprehensively assessed using validated self-reported questionnaires. RESULTS: After adjusting for age and sex, multiple linear regression models showed that higher MDA was significantly and inversely associated with anxiety (b = -0.23, p = 0.044), stress (b = -0.25, p = 0.022), and total psychological distress (b = -0.72, p = 0.022). Conversely, ST was identified as a consistent risk factor, positively predicting higher levels of anxiety (b = 0.45, p = 0.008), stress (b = 0.42, p = 0.008), and total distress (b = 1.11, p = 0.014). Furthermore, PA was inversely linked to anxiety (b = -0.35, p = 0.013) and successfully mediated the relationship between MDA and anxiety symptoms (Indirect Effect = -0.047, 95% CI: -0.10 to -0.01). No significant mediation effects were observed for depression or stress. CONCLUSIONS: The present study identifies robust inverse associations between MDA and symptoms of anxiety, depression, and stress in Chilean adolescents. A key finding is the specific pattern of relationships observed: while higher MDA is directly linked to lower levels of depression and stress, its association with anxiety is shared with levels of PA. Despite these findings, the cross-sectional nature of the study limits the establishment of causal relationships, and further longitudinal research is needed to confirm these directional pathways. FAU - Caamano-Navarrete, Felipe AU - Caamano-Navarrete F AUID- ORCID: 0000-0002-6884-589X AD - Physical Education Career, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Hernandez-Mosqueira, Claudio AU - Hernandez-Mosqueira C AUID- ORCID: 0000-0001-9392-2319 AD - Departamento de Ciencias de la Educacion, Universidad del Bio-Bio, Chillan 3780000, Chile. FAU - Contreras-Diaz, Guido AU - Contreras-Diaz G AD - Escuela de Kinesiologia, Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Lago Panguipulli 1390, Puerto Montt 5501842, Chile. FAU - Del-Cuerpo, Indya AU - Del-Cuerpo I AUID- ORCID: 0000-0002-2949-7896 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, 18071 Granada, Spain. FAU - Jerez-Mayorga, Daniel AU - Jerez-Mayorga D AUID- ORCID: 0000-0002-6878-8004 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, 18071 Granada, Spain. AD - Exercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile. FAU - Herrera-Valenzuela, Tomas AU - Herrera-Valenzuela T AUID- ORCID: 0000-0002-5219-5896 AD - Department of Physical Activity, Sports and Health Sciences, Faculty of Medical Sciences, Universidad de Santiago de Chile (USACH), Santiago 8370003, Chile. FAU - Guzman-Munoz, Eduardo AU - Guzman-Munoz E AUID- ORCID: 0000-0001-7001-9004 AD - School of Kinesiology, Faculty of Health, Universidad Santo Tomas, Talca 3460000, Chile. FAU - Hernandez-Martinez, Jordan AU - Hernandez-Martinez J AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. AD - Department of Education, Faculty of Humanities, Universidad de la Serena, La Serena 1700000, Chile. FAU - Valdes-Badilla, Pablo AU - Valdes-Badilla P AUID- ORCID: 0000-0002-3948-8280 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3460000, Chile. AD - Sports Coach Career, Faculty of Life Sciences, Universidad Vina del Mar, Vina del Mar 2520000, Chile. FAU - Nunez-Espinosa, Cristian AU - Nunez-Espinosa C AUID- ORCID: 0000-0002-9896-7062 AD - Escuela de Medicina, Universidad de Magallanes, Punta Arenas 6200000, Chile. AD - Centro Asistencial Docente y de Investigacion, Universidad de Magallanes, Punta Arenas 6200000, Chile. AD - Red Interuniversitaria de Envejecimiento Saludable de Latinoamerica y Caribe (RIES-LAC), Punta Arenas 6200000, Chile. FAU - Delgado-Floody, Pedro AU - Delgado-Floody P AUID- ORCID: 0000-0001-9952-993X AD - Department of Physical Education, Sport and Recreation, Universidad de La Frontera, Temuco 4811230, Chile. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13298326 OTO - NOTNLM OT - adolescents OT - anxiety OT - depression OT - mediation analysis OT - mediterranean diet OT - mental health OT - physical activity COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/17 CRDT- 2026/06/26 01:09 PHST- 2026/04/30 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - children13060825 [pii] AID - children-13-00825 [pii] AID - 10.3390/children13060825 [doi] PST - epublish SO - Children (Basel). 2026 Jun 17;13(6):825. doi: 10.3390/children13060825. PMID- 42353939 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 6 DP - 2026 Jun 1 TI - Moving Beyond Technique: A Conceptual Perspective for the Cuevas Medek Exercise Aligned with Modern Neuroscience. LID - 10.3390/children13060769 [doi] LID - 769 AB - Despite its increasing use in pediatric neurorehabilitation, Cuevas Medek Exercise (CME) remains rooted in clinical tradition, with limited theoretical articulation in relation to contemporary models of motor development, control, and learning. While clinical observations and reports from practice suggest possible functional benefits in children with motor delays, the absence of a conceptual framework limits its integration into evidence-informed physical therapy practice and education. This perspective proposes a conceptual model for CME that aligns its core principles with current theoretical constructs in motor behavior and developmental neuroscience. By examining key elements of CME-such as distal initiation, postural challenge, and task variability-through the lens of affordances, self-organization, and experience-dependent plasticity, the article presents CME not merely as a technique, but as a conceptual developmental approach informed by embodied action. We argue that such reframing may support more rigorous clinical reasoning, contribute to interdisciplinary dialogue, and inform a theoretical basis for future research exploring the proposed mechanisms and potential effects of CME. More broadly, this perspective contributes to ongoing discussions on how clinically derived interventions can be conceptually integrated within contemporary rehabilitation science. While the present article does not provide empirical validation, it offers a theoretical framework intended to inform future investigation and critical reflection in pediatric physical therapy. FAU - Becker, Cristiano AU - Becker C AD - CB Center Therapies and CME Courses, Cunha Pora 89890-000, SC, Brazil. FAU - Goulardins, Juliana Barbosa AU - Goulardins JB AUID- ORCID: 0000-0003-2639-6122 AD - Escola Bahiana de Medicina e Saude Publica, Salvador 40290-000, BA, Brazil. FAU - Marques, Juliana Cristina Fernandes Bilhar AU - Marques JCFB AUID- ORCID: 0000-0003-0429-1258 AD - Neurologic Rehabilitation Clinic, Sao Paulo 03410-010, SP, Brazil. FAU - Gajardo, Ramon Jeronimo Cuevas AU - Gajardo RJC AD - CME Therapy Spa, Santiago 7550000, Chile. LA - eng PT - Journal Article DEP - 20260601 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13296991 OTO - NOTNLM OT - Cuevas Medek Exercise OT - motor skills OT - neuroplasticity OT - pediatric rehabilitation OT - physical therapy COIS- J.B.G. is a certified Cuevas Medek Exercise (CME) Level 1 therapist, and J.C.B.F.M. is a certified CME Level 2 therapist. C.B. is a CME Level 4 therapist and certified instructor of the method. R.J.C.G., co-author of this manuscript, is the developer of the Cuevas Medek Exercise approach and has family ties to the founder of the method. The authors declare that the present manuscript is a conceptual perspective article and does not report experimental efficacy data or commercial evaluation of CME. The authors further declare that these affiliations did not influence the content or interpretation of this manuscript. EDAT- 2026/06/26 06:39 MHDA- 2026/06/26 06:40 PMCR- 2026/06/01 CRDT- 2026/06/26 01:09 PHST- 2026/04/29 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/26 06:40 [medline] PHST- 2026/06/26 06:39 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - children13060769 [pii] AID - children-13-00769 [pii] AID - 10.3390/children13060769 [doi] PST - epublish SO - Children (Basel). 2026 Jun 1;13(6):769. doi: 10.3390/children13060769. PMID- 42353900 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 6 DP - 2026 May 24 TI - Serum Zonulin and Chitinase (CHI3L1) as Biomarkers of Intestinal Permeability and Disease Activity in Pediatric Celiac Disease. LID - 10.3390/children13060730 [doi] LID - 730 AB - Objectives: To evaluate serum zonulin and CHI3L1 as indicators of intestinal permeability and disease activity in pediatric celiac disease and to explore their associations with histopathological findings and nutritional status. Methods: This prospective cross-sectional study included 131 pediatric patients with CD (aged 2-18 years) and 42 healthy controls. Patients were classified as newly diagnosed, gluten-free diet (GFD)-adherent, or GFD-nonadherent. Body mass index was calculated, and serum levels of micronutrients, zonulin, and CHI3L1 were measured using a sandwich enzyme-linked immunosorbent assay. Associations with histopathological findings, serological markers, and nutritional parameters were analyzed. Results: Age and sex distributions were similar across groups (mean age: 10.9 +/- 4.27 years). Serum zonulin and CHI3L1 levels were moderately positively correlated (r = 0.525, p < 0.001). Both biomarkers showed significant positive correlations with Marsh scores and tissue transglutaminase IgA levels. Zonulin was inversely correlated with hemoglobin, serum iron, and ferritin, whereas CHI3L1 showed negative correlations with hemoglobin and folate. Parathyroid hormone levels were positively correlated with both biomarkers. Receiver operating characteristic analysis demonstrated acceptable discriminatory performance for distinguishing CD from controls (AUC: 0.713 for zonulin and 0.709 for CHI3L1). Conclusions: Serum zonulin and CHI3L1 levels are associated with disease activity and mucosal injury in pediatric CD but do not directly reflect micronutrient status. These biomarkers may complement conventional monitoring parameters by providing additional information on intestinal permeability and inflammatory activity during follow-up. FAU - Tok, Aysegul Cebe AU - Tok AC AD - Department of Pediatric Gastroenterology, Etlik City Hospital, University of Health Sciences, Ankara 06010, Turkiye. FAU - Sayin, Oya AU - Sayin O AUID- ORCID: 0000-0003-0879-9091 AD - Department of Medical Laboratory Techniques, Vocational School of Health Services, Dokuz Eylul University, Izmir 35340, Turkiye. LA - eng PT - Journal Article DEP - 20260524 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13298287 OTO - NOTNLM OT - Marsh classification OT - gluten-free diet adherence OT - intestinal barrier function OT - mucosal injury OT - serological biomarkers COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 10:10 MHDA- 2026/06/26 10:11 PMCR- 2026/05/24 CRDT- 2026/06/26 01:09 PHST- 2026/04/11 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/26 10:11 [medline] PHST- 2026/06/26 10:10 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/05/24 00:00 [pmc-release] AID - children13060730 [pii] AID - children-13-00730 [pii] AID - 10.3390/children13060730 [doi] PST - epublish SO - Children (Basel). 2026 May 24;13(6):730. doi: 10.3390/children13060730. PMID- 42353899 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 6 DP - 2026 May 24 TI - Multimodal Exercise and Nutritional Interventions in Pediatric Cancer: Effects on Physical Function, Body Composition, and Metabolic Health-A Narrative Review. LID - 10.3390/children13060729 [doi] LID - 729 AB - Survival rates in pediatric cancer have increased substantially over recent decades. However, children and survivors frequently experience treatment-related alterations in physical function, body composition, bone health, and metabolic regulation. Chemotherapy, glucocorticoid exposure, physical inactivity, nutritional imbalance, and inflammatory and neuroendocrine disturbances may contribute to reduced lean mass, decreased bone mineral density, sarcopenic obesity, and long-term cardiometabolic risk. This narrative review critically summarizes current evidence on multimodal exercise and nutritional interventions in pediatric oncology, with particular attention to their effects on physical function, body composition, nutritional status, and metabolic health. Literature searches were conducted in PubMed, Scopus, and Web of Science up to April 2026, combining contextual evidence with studies evaluating combined exercise and nutritional strategies. Current evidence suggests that structured and supervised exercise, particularly resistance and combined aerobic-resistance training, is feasible and safe, and may improve cardiorespiratory fitness, muscle strength, functional capacity, and body composition. Nutritional care should be individualized, prioritizing adequate protein intake, micronutrient status, periodic reassessment of energy requirements, and body composition rather than relying on BMI alone. Nevertheless, available findings remain limited by small sample sizes, heterogeneous protocols, variable supervision, inconsistent outcome assessment, and limited long-term follow-up. Integrating exercise, nutrition, and regular monitoring into pediatric oncology care may help mitigate treatment-related functional and metabolic complications. Future studies should prioritize adequately powered randomized trials, standardized intervention protocols, objective monitoring of exercise intensity, harmonized body composition and functional outcomes, and longer follow-up to define clinically applicable multimodal care models. FAU - Ibanez-Camacho, Antonio AU - Ibanez-Camacho A AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14071 Cordoba, Spain. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AUID- ORCID: 0000-0003-0817-6804 AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14071 Cordoba, Spain. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AUID- ORCID: 0000-0002-0198-2793 AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14071 Cordoba, Spain. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Ciencias de la Actividad Fisica y el Deporte, Escuela Universitaria de Osuna (Centro Adscrito a la Universidad de Sevilla), 41640 Osuna, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AUID- ORCID: 0000-0002-9007-0242 AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14071 Cordoba, Spain. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Llorente-Cantarero, Francisco Jesus AU - Llorente-Cantarero FJ AUID- ORCID: 0000-0003-0018-2011 AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14071 Cordoba, Spain. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. LA - eng PT - Journal Article PT - Review DEP - 20260524 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13297246 OTO - NOTNLM OT - autonomic dysfunction OT - body composition OT - cancer survivors OT - exercise OT - nutrition therapy OT - pediatric leukemia OT - resistance training OT - sarcopenic obesity OT - sleep disturbances COIS- The authors declare no conflict of interest. EDAT- 2026/06/26 10:10 MHDA- 2026/06/26 10:11 PMCR- 2026/05/24 CRDT- 2026/06/26 01:09 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/26 10:11 [medline] PHST- 2026/06/26 10:10 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/05/24 00:00 [pmc-release] AID - children13060729 [pii] AID - children-13-00729 [pii] AID - 10.3390/children13060729 [doi] PST - epublish SO - Children (Basel). 2026 May 24;13(6):729. doi: 10.3390/children13060729. PMID- 42352833 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 6 DP - 2026 Jun 15 TI - Daily Routines and Habits in Individuals with Attention Deficit Hyperactivity Disorder: A Scoping Review. LID - 10.3390/bs16061000 [doi] LID - 1000 AB - This scoping review examined the current literature on routines and habits in individuals with attention deficit hyperactivity disorder (ADHD). To our knowledge, research in this area remains limited. Therefore, this review mapped which areas of daily routines are most affected in children and adults with ADHD and explored related assessments and interventions. A comprehensive search was conducted across four databases: PubMed, Scopus, CINAHL, and PsycINFO, using keywords including "attention deficit hyperactivity disorder," "ADHD," "routine," "habit," and "lifestyle." The findings identified four main domains in which individuals with ADHD experience difficulties: sleep hygiene, feeding, physical activity, and sedentary behaviors, with sleep hygiene addressed in more than half of the included studies. Study habits were addressed in only one included study. Among the 31 included studies, six involved interventions. The review also found that no validated assessment was specifically designed to measure routines or habits in individuals with ADHD, and that broader measures of routines, habits, or lifestyle were often non-validated or developed for a single project. Overall, the existing studies were concentrated primarily in pediatric populations, with limited research involving adults. These findings highlight important gaps in the literature and underscore the need for more research on routines and habits in adults with ADHD. They also support the development of assessments and interventions that specifically address these areas. FAU - Almudayfir, Ibrahim AU - Almudayfir I AD - Occupational Therapy Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh 1148, Saudi Arabia. AD - Rehabilitation Science Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Abdulkarim, Lama AU - Abdulkarim L AD - Independent Researcher, Riyadh 13343, Saudi Arabia. FAU - Rosenstein, Rachael AU - Rosenstein R AD - Outreach Therapy, Pittsburgh, PA 15213, USA. FAU - Yuen, Hon K AU - Yuen HK AUID- ORCID: 0000-0001-5696-1845 AD - Department of Occupational Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA. LA - eng PT - Journal Article PT - Review DEP - 20260615 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13295911 OTO - NOTNLM OT - ADHD OT - habit OT - lifestyle OT - routine OT - scoping review COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/15 CRDT- 2026/06/26 01:05 PHST- 2026/02/22 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:05 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - bs16061000 [pii] AID - behavsci-16-01000 [pii] AID - 10.3390/bs16061000 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jun 15;16(6):1000. doi: 10.3390/bs16061000. PMID- 42352707 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 6 DP - 2026 Jun 1 TI - Predicting Intrinsic Motivation After an Adventure Education Program in Primary Schools: Enjoyment, Self-Confidence and Resilience According to Gender. LID - 10.3390/bs16060874 [doi] LID - 874 AB - This study aimed to describe the pre-post changes in intrinsic motivation observed following the implementation of a parkour-based Adventure Education (AE) program in primary school students, and to examine the role of enjoyment, self-confidence, and resilience as variables statistically associated with intrinsic motivation, considering differences according to time (pre-test-post-test) and gender. The sample consisted of 492 fifth- and sixth-grade primary education students (249 boys and 243 girls) with a mean age of 10.67 years, enrolled in 12 Spanish schools. A quasi-experimental design with pre-test and post-test measures was used following the implementation of a seven-session program based on the Pedagogical Model of Adventure Education. Data were collected using instruments validated in the Spanish population: the intrinsic motivation subscale of the Perceived Locus of Causality Scale, the Physical Activity Enjoyment Scale to measure enjoyment, the self-confidence subscale of the Competitive State Anxiety Inventory, and the Connor-Davidson Resilience Scale to assess resilience. Statistical analysis was performed using SPSS 28.0 software, conducting descriptive analyses, correlations, and hierarchical multiple linear regressions to examine the statistical associations among the variables at each measurement point, along with a 2 x 2 repeated-measures ANOVA (time x gender). Post-test scores were significantly higher than pre-test scores for intrinsic motivation, enjoyment, self-confidence and resilience. Enjoyment was the variable most strongly statistically associated with intrinsic motivation, followed by self-confidence and resilience. The ANOVA showed a significant main effect of time, while no significant time x gender interaction was detected, meaning that the study found no evidence that the pre-post change differed between boys and girls. Given the single-arm pre-post design and the absence of a control group, these findings should be interpreted as preliminary descriptive evidence of pre-post change and associations, and not as a causal test of the program's effectiveness. FAU - Calmaestra-Sanchez, Andres AU - Calmaestra-Sanchez A AUID- ORCID: 0000-0001-6916-2284 AD - Department of Didactics of Musical, Plastic and Bodily Expression, University of Granada, 18015 Granada, Spain. FAU - Baena-Extremera, Antonio AU - Baena-Extremera A AUID- ORCID: 0000-0002-3597-4038 AD - Department of Didactics of Musical, Plastic and Bodily Expression, University of Granada, 18015 Granada, Spain. FAU - Gonzalez-Ruiz, Josue AU - Gonzalez-Ruiz J AUID- ORCID: 0000-0003-4977-9433 AD - Department of Didactics of Musical, Plastic and Bodily Expression, University of Granada, 18015 Granada, Spain. FAU - Sanchez-Fuentes, Jose Antonio AU - Sanchez-Fuentes JA AUID- ORCID: 0000-0003-3575-3507 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport, Faculty of Sport Sciences, University of Murcia, 30720 Murcia, Spain. LA - eng PT - Journal Article DEP - 20260601 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13296333 OTO - NOTNLM OT - adventure education OT - motivation OT - parkour COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/26 06:39 PMCR- 2026/06/01 CRDT- 2026/06/26 01:05 PHST- 2026/04/06 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/26 06:39 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:05 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - bs16060874 [pii] AID - behavsci-16-00874 [pii] AID - 10.3390/bs16060874 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jun 1;16(6):874. doi: 10.3390/bs16060874. PMID- 42351663 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 14 IP - 6 DP - 2026 May 29 TI - Organoids in Pediatric Congenital Hepatobiliary Diseases: Current Status and Progress in Clinical Translational Research. LID - 10.3390/biomedicines14061233 [doi] LID - 1233 AB - Organoids are three-dimensional culture systems that self-organize and partially recapitulate the architecture, cellular composition, and functional properties of native tissues. In pediatric congenital hepatobiliary diseases, persistent cholestasis, bile duct maldevelopment, epithelial injury, and progressive fibrosis often lead to cirrhosis, liver failure, or the necessity for liver transplantation. Compared with conventional two-dimensional cell culture and animal models, hepatobiliary organoids provide patient-derived, human-relevant platforms for modeling disease mechanisms, evaluating therapeutic responses, and exploring regenerative strategies. Unlike previous reviews that mainly discuss general organoid culture systems or broad liver disease modeling, this review is organized around clinically oriented translational endpoints, including mechanistic target discovery, prognostic stratification, therapeutic validation, and regenerative reconstruction. We further discuss current barriers to clinical translation, including reproducibility, scalability, vascularization, immune integration, manufacturing standardization, and patient-specific genetic, environmental, and dietary modifiers. By integrating disease-specific mechanisms with translational applications, this review provides a framework for understanding how organoid-based platforms may contribute to future diagnosis, risk assessment, therapeutic decision-making, and regenerative medicine in pediatric congenital hepatobiliary disorders. FAU - Zhang, Shanshan AU - Zhang S AUID- ORCID: 0009-0007-8447-5271 AD - Department of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, and Key Laboratory of Neonatal Disease, Ministry of Health, Children's Hospital of Fudan University, Shanghai 201102, China. FAU - Jiang, Jingying AU - Jiang J AD - Department of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, and Key Laboratory of Neonatal Disease, Ministry of Health, Children's Hospital of Fudan University, Shanghai 201102, China. FAU - Zheng, Shan AU - Zheng S AD - Department of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, and Key Laboratory of Neonatal Disease, Ministry of Health, Children's Hospital of Fudan University, Shanghai 201102, China. LA - eng GR - shslczdzk05703/Shanghai Public Health Clinical Center/ PT - Journal Article PT - Review DEP - 20260529 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC13297528 OTO - NOTNLM OT - congenital hepatobiliary diseases OT - mechanisms and translation OT - organoids COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:40 MHDA- 2026/06/26 06:41 PMCR- 2026/05/29 CRDT- 2026/06/26 01:01 PHST- 2026/03/31 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/26 06:41 [medline] PHST- 2026/06/26 06:40 [pubmed] PHST- 2026/06/26 01:01 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - biomedicines14061233 [pii] AID - biomedicines-14-01233 [pii] AID - 10.3390/biomedicines14061233 [doi] PST - epublish SO - Biomedicines. 2026 May 29;14(6):1233. doi: 10.3390/biomedicines14061233. PMID- 42351315 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260911 IS - 2046-4053 (Electronic) IS - 2046-4053 (Linking) VI - 15 IP - 1 DP - 2026 Jun 25 TI - A critical systematic review of the impact of sedentarism and physical inactivity on the cognitive performance of children. LID - 10.1186/s13643-026-03172-3 [doi] LID - 247 AB - OBJECTIVE: Sedentarism and physical inactivity are growing concerns for global health institutions, especially with the rising number of adolescents failing to meet daily physical activity guidelines. These inactive lifestyles can adversely affect cognitive functions during development. Thus, a systematic review of observational studies was conducted to evaluate the impact of sedentary behavior and physical inactivity on cognitive performance in children aged 6 to 12. METHODS: Eligible studies included English-language observational designs (such as cohort and case-control studies), enrolling neurotypical children classified as sedentary, insufficiently active, or physically inactive (experimental group), compared to active children (control group), according to ACSM recommendations. Studies were also required to report outcomes related to executive functions, academic performance metrics, memory, and attention. Systematic searches were conducted in MEDLINE (PubMed), Embase, Cochrane Library, Web of Science, and Scopus, from inception to February 2026. Risk of bias was assessed using the Risk Of Bias In Non-randomised Studies-of Exposure (ROBINS-E) tool. Data were synthesized through a narrative method. RESULTS: Of the 5438 articles initially identified, two studies directly compared inactive and active groups with contrasting results. One showed negative associations between light, moderate physical activity, and total activity time with verbal and perceptual skills in the active group, alongside positive effects of vigorous PA and sedentary behavior on verbal skills. The other pointed positive dose-response effects of sustained moderate-to-vigorous PA trajectories on academic achievement (reading, mathematics, language). However, caution is advised when interpreting these results due to the high risk of bias in both studies, lack of control for confounding variables, and insufficient information on missing data and blinding procedures. While other studies show significant associations between physical activity and cognitive measures, it is crucial to question whether group compositions accurately reflect the cognitive effects of exercise. Given the limited number of articles meeting international physical activity organization criteria, caution is recommended when interpreting the cognitive effects of physical activity-related exposures in children. CONCLUSIONS: This review introduces a novel data analysis approach that classified groups based on established physical activity recommendations, aiming to standardize group criteria. This method potentially sparks essential debates on group definitions and contributes to enhancing the methodological quality of future observational or experimental studies, enabling more robust and reliable data interpretation. CI - (c) 2026. The Author(s). FAU - Petraconi, Nathalia AU - Petraconi N AD - Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil. nathaliapetraconi@hotmail.com. FAU - Henrique, Jessica Salles AU - Henrique JS AD - Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil. FAU - Cardoso, Fabrizio Dos Santos AU - Cardoso FDS AD - Hospital do Cancer de Muriae, Fundacao Cristiano Varella (FCV), Muriae, MG, Brazil. AD - Afya Centro Universitario Itaperuna (UNIREDENTOR), Itaperuna, RJ, Brazil. AD - Hospital Sao Vicente de Paulo (HSVP), Bom Jesus do Itabapoana, RJ, Brazil. FAU - Vital, Flavia Maria Ribeiro AU - Vital FMR AD - Hospital do Cancer de Muriae, Fundacao Cristiano Varella (FCV), Muriae, MG, Brazil. AD - Afya Centro Universitario Itaperuna (UNIREDENTOR), Itaperuna, RJ, Brazil. AD - Vital Knowledge, Muriae, MG, Brazil. FAU - Arida, Ricardo Mario AU - Arida RM AD - Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil. AD - Rede Nacional de Ciencia para Educacao (Rede CpE), Rio de Janeiro, RJ, Brazil. FAU - Martins, Camila Bertini AU - Martins CB AD - Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil. FAU - Gomes da Silva, Sergio AU - Gomes da Silva S AD - Hospital do Cancer de Muriae, Fundacao Cristiano Varella (FCV), Muriae, MG, Brazil. sgomesilva@hotmail.com. AD - Afya Centro Universitario Itaperuna (UNIREDENTOR), Itaperuna, RJ, Brazil. sgomesilva@hotmail.com. AD - Rede Nacional de Ciencia para Educacao (Rede CpE), Rio de Janeiro, RJ, Brazil. sgomesilva@hotmail.com. AD - D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil. sgomesilva@hotmail.com. LA - eng GR - 301771/2022-7/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20260625 PL - England TA - Syst Rev JT - Systematic reviews JID - 101580575 SB - IM MH - Humans MH - Child MH - *Sedentary Behavior MH - *Cognition/physiology MH - *Exercise MH - Executive Function PMC - PMC13555928 OTO - NOTNLM OT - Academic achievement OT - Child OT - Executive function OT - Physical fitness OT - Physical inactivity OT - Sedentary behavior COIS- Declarations. Competing interests: The authors declare that they have no conflicts of interest. All authors read and approved the final manuscript. EDAT- 2026/06/26 13:10 MHDA- 2026/09/09 11:38 PMCR- 2026/06/25 CRDT- 2026/06/26 00:05 PHST- 2024/06/14 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 00:05 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s13643-026-03172-3 [pii] AID - 3172 [pii] AID - 10.1186/s13643-026-03172-3 [doi] PST - epublish SO - Syst Rev. 2026 Jun 25;15(1):247. doi: 10.1186/s13643-026-03172-3. PMID- 42351134 OWN - NLM STAT- MEDLINE DCOM- 20260927 LR - 20260930 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Dietary patterns and oral health practices among primary school children aged 6-15 years in urban informal settlements of Eldoret City, Kenya. LID - 10.1186/s12903-026-08778-6 [doi] LID - 1850 AB - BACKGROUND: Dental caries remains one of the most prevalent chronic conditions among school-aged children, disproportionately affecting those in informal settlements where dietary risks and preventive oral health services are limited. AIM: This study assessed dietary patterns, oral hygiene practices, and their association with dental caries among primary school children aged 6-15 years in informal settlements of Eldoret City in Uasin Gishu County, Kenya. METHODS: The study adopted a school-based cross-sectional design and involved 407 primary school children selected using proportionate stratified random sampling. Data was collected using a validated and pretested structured questionnaire, while clinical oral assessment was based on WHO field guidelines for the examination of dental caries. Data was analyzed using SPSS v.26. Chi-square tests assessed associations, and bivariate and multivariate logistic regression models were used to identify independent dietary patterns and oral hygiene practices associated with dental caries. RESULTS: Out of 407 children, 55.3% were females, and their average mean age was 12.15 +/- 2.98 years. The prevalence of dental caries was 26.0% (95% CI: 21.8-30.3). Daily consumption of sugary foods and beverages and suboptimal oral hygiene practices were relatively high. Multivariate logistic regression models revealed daily intake of biscuits, cakes, sweet pies, and buns (AOR = 2.31; 95% CI: 1.36-3.74; p = 0.004), daily consumption of sweets and candy (AOR = 2.42; 95% CI: 1.35-3.91; p = 0.006), brushing less than twice daily (AOR = 2.92; 95% CI: 1.18-3.87; p = 0.023), and not using fluoride toothpaste (AOR = 1.83; 95% CI: 1.12-2.61; p = 0.043) were independently associated with higher odds of dental caries among primary school children. CONCLUSION: Integrated school- and community-based prevention strategies targeting dietary patterns and oral hygiene promotion are urgently needed to reduce preventable oral health inequities among vulnerable schoolchildren. CI - (c) 2026. The Author(s). FAU - Wandia, Florence AU - Wandia F AD - School of Health Sciences, University of Kabianga, Kericho, Kericho County, Kenya. FAU - Wanzala, Joel AU - Wanzala J AD - School of Health Sciences, University of Kabianga, Kericho, Kericho County, Kenya. abbysansiojoel@gmail.com. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Child MH - Female MH - Kenya/epidemiology MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - *Dental Caries/epidemiology MH - *Oral Hygiene/statistics & numerical data MH - *Feeding Behavior MH - *Diet/statistics & numerical data MH - Prevalence MH - *Oral Health MH - Toothbrushing/statistics & numerical data MH - Urban Population MH - Fluoride Treatment PMC - PMC13617819 OTO - NOTNLM OT - Dental caries OT - Dietary patterns OT - Informal settlement OT - Kenya OT - Oral health practices OT - School children COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Institutional Scientific Ethics Review Committee (ISERC) of the University of Eastern Africa Baraton (UEAB/ISERC/05/02/2025). The study received a research permit/license for the National Commission for Science, Technology and Innovation (NACOSTI/P/25/4175815). Additionally, permission was sought from the Ministry of Education and selected primary school administration. Informed consent was obtained from the parents or legal guardians of all the participants, as they aged 15 years and below. Researchers explained the aim, benefits, duration, and the activities that the study involved to parents and guardians. Participation was voluntary, and participants were informed that they could withdraw from the study at any time without consequences. Confidentiality and privacy were maintained by using anonymized data and private interviews. Additionally, the study adhered to the principles of the Declaration of Helsinki on ethical research involving human participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:50 MHDA- 2026/09/28 05:33 PMCR- 2026/06/25 CRDT- 2026/06/25 23:59 PHST- 2026/02/20 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/09/28 05:33 [medline] PHST- 2026/06/26 00:50 [pubmed] PHST- 2026/06/25 23:59 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12903-026-08778-6 [pii] AID - 8778 [pii] AID - 10.1186/s12903-026-08778-6 [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 25;26(1):1850. doi: 10.1186/s12903-026-08778-6. PMID- 42351094 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260918 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Strengthening cancer prevention in european schools: a randomized controlled trial of digital interventions in adolescents: the SUNRISE program. LID - 10.1186/s12889-026-28185-4 [doi] LID - 2558 AB - BACKGROUND: Cancer remains a leading cause of mortality worldwide, with a substantial proportion of cases attributable to modifiable lifestyle-related risk factors that emerge during adolescence and often persist into adulthood. Despite the importance of this developmental period for habit formation, evidence on scalable, theory-driven, and sustainable school-based prevention interventions remains limited. The SUNRISE project addresses this gap by evaluating a co-created, digitally supported life-skills programme designed for routine school settings. METHODS: SUNRISE is a pragmatic, multinational, cluster randomised controlled trial conducted in approximately 80 primary and secondary schools across eight European countries (Greece, Switzerland, Slovenia, Spain, Cyprus, Italy, Belgium, and Romania), recruiting around 4,000 students. Classes are randomised at the class level (3:1) to either a six-month digitally enhanced life-skills intervention or standard education. The primary aim of the study is to evaluate the feasibility, implementation, and sustainability of the intervention in real-world school settings, with secondary exploratory assessment of behavioural outcomes. The intervention integrates multiple digital components, including a mobile-based life-skills coaching programme, a conversational assistant, educational and serious games, influencer-led media literacy content, moderated social interaction platforms, and teacher-led educational modules. Intervention design is guided by the Capability-Opportunity-Motivation Behaviour (COM-B) model and developed through systematic co-creation with students, educators, parents, public health experts, and policymakers within a School Living Lab framework. Feasibility, implementation, and sustainability are evaluated using the RE-AIM and PRISM frameworks. Secondary behavioural outcomes include substance use, dietary and physical activity behaviours, mental well-being, stress, social skills, critical thinking towards media and advertising, and critical coping with food-related information, assessed at baseline, 6 months, and 18 months. DISCUSSION: SUNRISE integrates behavioural science, participatory design, and digital innovation to address adolescent health behaviours in real-world educational contexts. By embedding implementation and sustainability evaluation alongside behavioural outcomes, the study aims to generate actionable evidence on how multi-component digital interventions can be adopted, adapted, and maintained across diverse school systems. Findings are expected to inform future large-scale, theory-driven, equitable, and sustainable cancer prevention strategies targeting adolescents across Europe. TRIAL REGISTRATION: NCT06931847 (registration date: 2025-04-09). CI - (c) 2026. The Author(s). FAU - Barasoain, Maitane AU - Barasoain M AUID- ORCID: 0000-0002-9142-4161 AD - Biobizkaia Health Research Institute, Plaza Cruces 12, Barakaldo, Bizkaia, 48903, Spain. FAU - Velez-Del-Burgo, Ainara AU - Velez-Del-Burgo A AUID- ORCID: 0000-0002-1283-2336 AD - Biobizkaia Health Research Institute, Plaza Cruces 12, Barakaldo, Bizkaia, 48903, Spain. FAU - Astigarraga, Itziar AU - Astigarraga I AUID- ORCID: 0000-0002-5012-0137 AD - Cruces University Hospital, Osakidetza, Barakaldo, Bizkaia, Spain. FAU - Haug, Severin AU - Haug S AUID- ORCID: 0000-0002-6539-5045 AD - Swiss Research Institute for Public Health and Addiction ISGF, University of Zurich, Zurich, Switzerland. FAU - Kiselev, Nikolai AU - Kiselev N AUID- ORCID: 0000-0003-0617-0353 AD - Swiss Research Institute for Public Health and Addiction ISGF, University of Zurich, Zurich, Switzerland. FAU - Koutra, Kleio AU - Koutra K AUID- ORCID: 0000-0001-9713-5013 AD - Department of Social Work, Social Applied Research and Social Work Lab, Hellenic Mediterranean University, Chania, Greece. FAU - Kilintzis, Vassilis AU - Kilintzis V AUID- ORCID: 0000-0002-9783-6757 AD - BMI Lab, ECE-HMU & CBML, FORTH-ICS, Thessaloniki, Greece. FAU - Krini, Maria AU - Krini M AUID- ORCID: 0000-0001-8122-963X AD - Pagkyprios Syndesmos Karkinopathon Kai Filon 1986 (PASYKAF), Department of Research and Development, Nicosia, Cyprus. FAU - Pampaka, Theophano AU - Pampaka T AD - Pagkyprios Syndesmos Karkinopathon Kai Filon 1986 (PASYKAF), Department of Research and Development, Nicosia, Cyprus. FAU - Hudders, Liselot AU - Hudders L AUID- ORCID: 0000-0002-9585-7175 AD - Dept. of Communication Sciences, Center for Persuasive Communication, Ghent University, Ghent, Belgium. FAU - De Keyzer, Eline AU - De Keyzer E AUID- ORCID: 0009-0003-9321-0516 AD - Dept. of Communication Sciences, Center for Persuasive Communication, Ghent University, Ghent, Belgium. FAU - Serrano, Polonca AU - Serrano P AUID- ORCID: 0000-0002-5240-7748 AD - Alma Mater Europaea University, Maribor, Slovenia. FAU - Pilotti, Chiara AU - Pilotti C AD - FAVO ETS ODV, Federazione Italiana delle Associazioni di Volontariato in Oncologia ETS - Organizzazione di Volontariato, Rome, Italy. FAU - Del Campo, Laura AU - Del Campo L AD - FAVO ETS ODV, Federazione Italiana delle Associazioni di Volontariato in Oncologia ETS - Organizzazione di Volontariato, Rome, Italy. FAU - Nicoara, Delia AU - Nicoara D AUID- ORCID: 0000-0003-1010-3049 AD - Institute of Oncology Prof. Dr. Ion Chiricuta: Cluj-Napoca, Cluj-Napoca County, Romania. FAU - Nicoara, Niculina AU - Nicoara N AUID- ORCID: 0009-0008-7642-165X AD - Institute of Oncology Prof. Dr. Ion Chiricuta: Cluj-Napoca, Cluj-Napoca County, Romania. FAU - Molina-Barcelo, Ana AU - Molina-Barcelo A AUID- ORCID: 0000-0001-5113-6475 AD - Cancer and Public Health Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, Valencia, Spain. FAU - de Pablo Pardo, Teresa AU - de Pablo Pardo T AUID- ORCID: 0009-0004-7878-9643 AD - Cancer and Public Health Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, Valencia, Spain. FAU - Verduyn, Stefanie AU - Verduyn S AD - GEZOND, Flemish Institute for Healthy Living, Brussels, Belgium. FAU - Cea, Gloria AU - Cea G AUID- ORCID: 0000-0002-6947-4672 AD - BRIDG OU, Tallinn, Estonia. FAU - Katsapi, Chrysoula AU - Katsapi C AUID- ORCID: 0000-0002-3538-0432 AD - Department of Social Work, Social Applied Research and Social Work Lab, Hellenic Mediterranean University, Chania, Greece. FAU - Segal, Lucas Javier AU - Segal LJ AUID- ORCID: 0009-0005-5544-2994 AD - PredictBy Research and Consulting, Barcelona, Spain. FAU - Tsoupouroglou, Iraklis AU - Tsoupouroglou I AUID- ORCID: 0000-0003-4666-1237 AD - Lab of Medical Physics and Digital Innovation, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Guerra, Barbara AU - Guerra B AUID- ORCID: 0000-0003-3389-1973 AD - PARTICLE Summary, Lisbon, Portugal. FAU - Triantafyllidis, Andreas AU - Triantafyllidis A AUID- ORCID: 0000-0002-6938-8256 AD - Information Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, Greece. FAU - Arana-Arri, Eunate AU - Arana-Arri E AUID- ORCID: 0000-0001-9759-333X AD - Biobizkaia Health Research Institute, Plaza Cruces 12, Barakaldo, Bizkaia, 48903, Spain. eunate.aranaarri@osakidetza.eus. AD - Cruces University Hospital, Osakidetza, Barakaldo, Bizkaia, Spain. eunate.aranaarri@osakidetza.eus. CN - SUNRISE Study Group LA - eng SI - ClinicalTrials.gov/NCT06931847 PT - Journal Article PT - Multicenter Study PT - Pragmatic Clinical Trial PT - Randomized Controlled Trial DEP - 20260625 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Europe MH - *Health Promotion/methods MH - *Neoplasms/prevention & control MH - Program Evaluation MH - *School Health Services/organization & administration MH - Schools PMC - PMC13555859 OTO - NOTNLM OT - Adolescent health OT - Cancer prevention OT - Cluster randomised controlled trial OT - Digital health intervention OT - Health promotion OT - Implementation science OT - Life skills OT - School-based intervention COIS- Declarations. Ethics approval and consent to participate: All procedures performed in the study adhered to the ethical standards of the institutional research Ethics Committee of each Country and the 1964 Declaration of Helsinki and its subsequent amendments. This article does not contain any studies with animals performed by any authors. Consent to participate will be obtained from patients before their involvement in the study. Age-appropriate participant information sheets and consent/assent forms for different age groups, as well as for parents or legal guardians, are provided in Supplementary Material (Supplementary File 5). The protocol has been approved by the local clinical research ethics committees. Details of ethics approvals, including approval reference numbers, are provided in Supplementary Material (Supplementary File 4). Consent for publication: Not applicable. Competing interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. FIR - Segkouli, Sofia IR - Segkouli S FIR - Laloumis, Nikos IR - Laloumis N FIR - Alexiadis, Anastasios IR - Alexiadis A FIR - Lithoxoidou, Evdoxia-Eirini IR - Lithoxoidou EE FIR - Spirou, Aggeliki IR - Spirou A FIR - Georgiadis, Charalabos IR - Georgiadis C FIR - Kafetzopoulos, Sotirios IR - Kafetzopoulos S FIR - Votis, Konstantinos IR - Votis K FIR - Tzovaras, Dimitrios IR - Tzovaras D FIR - Kondylakis, Haridimos IR - Kondylakis H FIR - Lina, Pelekidou IR - Lina P FIR - Pityanou, Konstantina IR - Pityanou K FIR - Micheli, Katerina IR - Micheli K FIR - Samara, Rafaela IR - Samara R FIR - Konstantinidis, Theocharis IR - Konstantinidis T FIR - Maniadi, Evaggelia IR - Maniadi E FIR - Markakis, Evangelos IR - Markakis E FIR - Tziraki, Charikleia IR - Tziraki C FIR - Marias, Kostas IR - Marias K FIR - Tsiknakis, Emmanouil IR - Tsiknakis E FIR - Philippou, Nicolas IR - Philippou N FIR - Xydia, Stavri IR - Xydia S FIR - Ferentinou, Marisa IR - Ferentinou M FIR - DeJans, Steffi IR - DeJans S FIR - Van de Sompel, Dieneke IR - Van de Sompel D FIR - Beuckels, Emma IR - Beuckels E FIR - Pearce, Hayley IR - Pearce H FIR - Schreiner, Tania IR - Schreiner T FIR - Albert, Yvette IR - Albert Y FIR - Bogataj, David IR - Bogataj D FIR - Inkret, Anja IR - Inkret A FIR - Goswami, Nandu IR - Goswami N FIR - Bamidis, Panagiotis IR - Bamidis P FIR - Reppou, Sofia IR - Reppou S FIR - Spachos, Dimitrios IR - Spachos D FIR - Gallego, Alba IR - Gallego A FIR - Mallo, Irene IR - Mallo I FIR - Buhid, Eduardo IR - Buhid E FIR - Fico, Giuseppe IR - Fico G FIR - Cabrera, Maria Fernanda IR - Cabrera MF FIR - Villanueva, Francisco Lupianez IR - Villanueva FL FIR - Van der Feen, Justine IR - Van der Feen J FIR - Dietrich, Nick IR - Dietrich N FIR - Roca-Umbert, Ana IR - Roca-Umbert A FIR - Manso, Marco IR - Manso M FIR - Pires, Jose IR - Pires J FIR - Vanaclocha, Mercedes IR - Vanaclocha M FIR - Romeo, Paula IR - Romeo P FIR - Manyogil, Belen IR - Manyogil B FIR - Gandia, Mireia IR - Gandia M FIR - Garcia, Oscar IR - Garcia O FIR - Marulanda, Erika IR - Marulanda E FIR - Valentinotti, Rachele IR - Valentinotti R FIR - Iannelli, Elisabetta IR - Iannelli E FIR - De Lorenzo, Francesco IR - De Lorenzo F FIR - De Persis, Davide IR - De Persis D FIR - Summa, Alice IR - Summa A FIR - Sanchez Perez, Alvaro IR - Sanchez Perez A FIR - Peiro Callizo, Enrique IR - Peiro Callizo E FIR - Orcajo-Lago, Janire IR - Orcajo-Lago J FIR - Meijide, Susana IR - Meijide S FIR - Idoyaga-Uribbarrena, Jon Eneko IR - Idoyaga-Uribbarrena JE FIR - Gomez-Sanchez, Veronica IR - Gomez-Sanchez V FIR - Martin-Rodriguez, Haizea IR - Martin-Rodriguez H FIR - de Bareno, Macarena IR - de Bareno M FIR - Llarena, Marta IR - Llarena M FIR - Liakopoulos, Vassilis IR - Liakopoulos V FIR - Panagopoulou, Maria IR - Panagopoulou M FIR - Mavromanolakis, Giorgos IR - Mavromanolakis G FIR - Manteli, Maria IR - Manteli M FIR - Koulouris, Pavlos IR - Koulouris P FIR - Sotiriou, Sofoklis IR - Sotiriou S FIR - Neven, Loes IR - Neven L FIR - Rizvi, Katie IR - Rizvi K FIR - Rusu, Oana IR - Rusu O FIR - Todea, Diana IR - Todea D FIR - Cristea, Laura IR - Cristea L FIR - Trifulescu, Cristina IR - Trifulescu C FIR - Wenger, Andreas IR - Wenger A FIR - Boumparis, Niko IR - Boumparis N FIR - Studhalter, Olivia IR - Studhalter O FIR - Champion, Katrina IR - Champion K FIR - Teesson, Maree IR - Teesson M FIR - Newton, Nicola IR - Newton N EDAT- 2026/06/26 04:10 MHDA- 2026/09/09 07:07 PMCR- 2026/06/25 CRDT- 2026/06/25 23:58 PHST- 2026/01/31 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/26 04:10 [pubmed] PHST- 2026/06/25 23:58 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12889-026-28185-4 [pii] AID - 28185 [pii] AID - 10.1186/s12889-026-28185-4 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 25;26(1):2558. doi: 10.1186/s12889-026-28185-4. PMID- 42351021 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1471-2369 (Electronic) IS - 1471-2369 (Linking) VI - 27 IP - 1 DP - 2026 Jun 25 TI - Screening for urinary abnormalities in healthy school children living in an African urban megacity. LID - 10.1186/s12882-026-05151-1 [doi] LID - 391 AB - BACKGROUND: Urinary screening is a useful and non-invasive tool for identifying occult kidney disease in asymptomatic children and may be an important initial step in preventing progressive kidney disease. However, this screening is not commonly performed in children living in low-resource countries, including the Democratic Republic of the Congo (DRC). This study aimed to determine the prevalence of albuminuria and its associated factors among healthy school children living in DRC. In addition, the study examined the prevalence of urinary abnormalities detected by dipstick in this population. METHODS: This cross-sectional study was conducted in 17 schools in Kinshasa. A multistage sampling procedure was applied, and 497 healthy school children aged 6 to 16 were randomly recruited. Anthropometric and clinical data were collected. Using a single-sample measurement, urinary albumin-to-creatinine ratio (ACR) was determined by an immunoturbidimetric method, and dipstick tests were performed to detect other urinary abnormalities (leukocyturia, nitrituria, proteinuria, hematuria). Albuminuria was defined as ACR >/= 30 mg/g. Logistic regression was used to identify clinical factors associated with albuminuria. RESULTS: Among the 497 school children (208 boys and 289 girls), 58 had single-sample albuminuria, corresponding to a prevalence of 11.7%. There was no significant association between albuminuria and clinical variables based on univariate logistic regression analysis. Dipstick urinary abnormalities were present in 113 children (22.7%). Specifically, leukocyturia, nitrituria, proteinuria, and hematuria were detected in 14.3%, 1.6%, 8.2%, and 1.6% of participants, respectively. Leukocyturia and nitrituria were significantly more common among girls (p < 0.001). CONCLUSION: Urinary abnormalities are common among asymptomatic school children in the DRC. Although a single measurement was performed, these results raise the relevant question of the usefulness of urinary screening in children living in resource-limited settings. However, the feasibility, cost, and potential benefits of such a program warrant further evaluation in these settings. CI - (c) 2026. The Author(s). FAU - Nkoy, Agathe Bikupe AU - Nkoy AB AUID- ORCID: 0000-0002-1563-380X AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. agath.nkoy@gmail.com. FAU - Matoka, Therance Tobo AU - Matoka TT AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. FAU - Minimbu, Orielle Mafuta AU - Minimbu OM AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. FAU - Odio, Bienvenu Matondo AU - Odio BM AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. FAU - Levtchenko, Elena AU - Levtchenko E AD - Department of Pediatric Nephrology, Amsterdam University Medical Centers, Amsterdam, The Netherlands. FAU - Ekulu, Pepe Mfutu AU - Ekulu PM AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Nephrol JT - BMC nephrology JID - 100967793 SB - IM MH - Humans MH - Female MH - Child MH - Male MH - Cross-Sectional Studies MH - *Albuminuria/epidemiology/diagnosis/urine MH - Democratic Republic of the Congo/epidemiology MH - *Mass Screening/methods MH - Adolescent MH - Prevalence MH - *Urban Population MH - Urinalysis MH - Proteinuria/epidemiology/diagnosis PMC - PMC13317383 OTO - NOTNLM OT - African children OT - Albuminuria OT - Dipstick OT - Proteinuria OT - Screening COIS- Declarations. Ethical approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki, approved by the National Ethics Committee of the Kinshasa School of Public Health (ESP/CE/256/2019) and was authorized by the relevant administrative and school authorities. Written informed consent was obtained from parents or legal guardians of children before the recruitment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:42 MHDA- 2026/06/30 06:31 PMCR- 2026/06/25 CRDT- 2026/06/25 23:56 PHST- 2026/02/08 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/06/30 06:31 [medline] PHST- 2026/06/26 00:42 [pubmed] PHST- 2026/06/25 23:56 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12882-026-05151-1 [pii] AID - 5151 [pii] AID - 10.1186/s12882-026-05151-1 [doi] PST - epublish SO - BMC Nephrol. 2026 Jun 25;27(1):391. doi: 10.1186/s12882-026-05151-1. PMID- 42351010 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Breaking down breakfast: the relationship between morning meals and learning difficulties in adolescents. LID - 10.1186/s12887-026-07085-x [doi] LID - 856 AB - BACKGROUND: Learning difficulties (LDs) impair academic performance and cognitive function. Dietary factors, particularly the composition of breakfast, may influence LDs. OBJECTIVE: To examine the association between breakfast composition and LDs in adolescents. METHODS: A cross-sectional study was conducted among 501 adolescents aged 10-19 from four schools in Jahrom, Iran. Trained dietitians collected dietary data using three non-consecutive 24-hour recalls (two on weekdays and one on a weekend). Weight and height were measured following a standardized protocol. Additionally, LDs were assessed using the validated Colorado Learning Difficulties Score (CLDS) questionnaire. Higher scores of CLDS reflect greater LDs. RESULTS: Using the CLDS, adolescents were classified into four equal quartiles. In all food group analyses, adolescents who consumed fewer than one serving/day were considered the reference group. Adolescents who consumed more than one serving of dairy had lower odds of being in the highest CLDS quartile (1-2 servings: OR 0.42; 95% CI 0.20-0.87; 3-4 servings: OR 0.19; 95% CI 0.07-0.47; >4 servings: OR 0.22; 95% CI 0.05-0.86). Furthermore, adolescents who consumed more than four servings of simple sugar had higher odds of being in the highest CLDS quartile (> 4 servings: OR 3.60; 95% CI 1.09-11.8). CONCLUSION: Our findings suggest that higher dairy intake and lower consumption of simple sugar waere associated with lower odds of LDs in adolescents. Further longitudinal studies are warranted. CI - (c) 2026. The Author(s). FAU - Rahmanian, Reza AU - Rahmanian R AUID- ORCID: 0009-0004-0125-5096 AD - School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Pirbasti, Ali Razeghi AU - Pirbasti AR AUID- ORCID: 0009-0003-7237-5784 AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Shaygantabar, Mohsen AU - Shaygantabar M AUID- ORCID: 0009-0006-5483-9495 AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Javaheri-Tafti, Fatemeh AU - Javaheri-Tafti F AUID- ORCID: 0009-0002-3299-2684 AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Bahreini-Boroujeni, Leyli Zahra AU - Bahreini-Boroujeni LZ AUID- ORCID: 0009-0006-3898-051X AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Hatami, Alireza AU - Hatami A AUID- ORCID: 0009-0001-8712-0165 AD - Department of Clinical Nutrition School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Khoshrang, Andisheh AU - Khoshrang A AUID- ORCID: 0009-0009-3149-2873 AD - School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Sajedi, Leila AU - Sajedi L AUID- ORCID: 0009-0003-0330-7657 AD - Department of Education, Faculty of Teachers Education, Farhangian University, Shiraz, Iran. FAU - Ajami, Marjan AU - Ajami M AUID- ORCID: 0000-0002-6820-550X AD - Department of Food and Nutrition Policy and Planning Research, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Esmaili, Mina AU - Esmaili M AUID- ORCID: 0000-0002-8422-7864 AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Houshiarrad, Anahita AU - Houshiarrad A AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. anahrad@yahoo.com. FAU - Doaei, Saeid AU - Doaei S AUID- ORCID: 0000-0002-2532-7478 AD - Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, P.O. Box 19395-4741, Iran. Sdoaei@sbmu.ac.ir. AD - Unit of Nutrition and Cancer, Cancer Epidemiology Research Program Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. Sdoaei@sbmu.ac.ir. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Adolescent MH - *Learning Disabilities/etiology/epidemiology MH - Cross-Sectional Studies MH - *Breakfast/psychology MH - Child MH - Female MH - Male MH - Iran MH - *Feeding Behavior PMC - PMC13560118 OTO - NOTNLM OT - Breakfast OT - Cognitive function OT - Diary intake OT - Learning disabilities COIS- Declarations. Ethics approval and consent to participate: The research received approval from the Ethics Committee of the National Nutrition and Food Technology Research Institute at Shahid Beheshti University of Medical Sciences, Iran (IR.SBMU.NNFTRI.REC.1402.052). The study adheres to the principles outlined in the Declaration of Helsinki. All participants provided written informed consent before participating in this study. All personal information about participants will be kept secure in a database. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:51 MHDA- 2026/09/10 05:36 PMCR- 2026/06/25 CRDT- 2026/06/25 23:55 PHST- 2025/11/26 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/09/10 05:36 [medline] PHST- 2026/06/26 00:51 [pubmed] PHST- 2026/06/25 23:55 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12887-026-07085-x [pii] AID - 7085 [pii] AID - 10.1186/s12887-026-07085-x [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 25;26(1):856. doi: 10.1186/s12887-026-07085-x. PMID- 42351008 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Reclassification of SGA and EUGR in very preterm infants after the introduction of Fenton-2025: a retrospective cohort comparison with INTERGROWTH-21st and Fenton-2013. LID - 10.1186/s12887-026-07215-5 [doi] LID - 855 AB - BACKGROUND: In very preterm infants, the classification of small for gestational age (SGA) and extrauterine growth restriction (EUGR) depends on the growth chart used. In this context, the classification implications of the newly introduced Fenton-2025 curves have not yet been evaluated in this population. We compared SGA and EUGR classification across Fenton-2025, INTERGROWTH-21st, and Fenton-2013, and examined chart-specific associations between EUGR and major neonatal morbidities. METHODS: This retrospective single-centre cohort study included 272 infants born at 24-32 weeks' gestation. SGA was defined as birth weight below the 10th percentile. EUGR was defined as discharge weight-for-age Z score below - 2. Associations between chart-defined EUGR and neonatal morbidities were examined using multivariable logistic regression adjusted for gestational age, birth weight, and sex. RESULTS: SGA rates differed in rank order across the three charts, being lowest with Fenton-2013 (9.9%), intermediate with INTERGROWTH-21st (15.8%), and highest with Fenton-2025 (24.3%). For EUGR, the ordering was different: rates were lowest with INTERGROWTH-21st (26.1%), intermediate with Fenton-2013 (33.5%), and highest with Fenton-2025 (40.8%). Despite this difference in rank order, the three charts showed a nested classification pattern. Compared with INTERGROWTH-21st, Fenton-2025 classified 56% more infants (n = 40) as EUGR. Nevertheless, in adjusted analyses, infants classified as EUGR according to the Fenton 2013 and INTERGROWTH-21st charts were associated with higher adjusted odds (aOR 6.37, 95% CI 2.07-19.57, and aOR 5.03, 95% CI 1.82-13.90, respectively) of necrotising enterocolitis (>/= stage II) compared to non-EUGR infants, and this higher adjusted odds persisted after reclassification using the Fenton 2025 chart (aOR 4.96, 95% CI 1.68-14.64). CONCLUSIONS: Fenton-2025 applies a more inclusionary approach in classifying very preterm infants as SGA and EUGR compared with INTERGROWTH-21st and Fenton-2013. The clinical implications of this broader classification require further outcome-linked validation. CI - (c) 2026. The Author(s). FAU - Gur, Kutlay AU - Gur K AUID- ORCID: 0000-0001-6444-8101 AD - Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, 34668, Turkiye. kutlaygur@gmail.com. FAU - Topcuoglu, Sevilay AU - Topcuoglu S AUID- ORCID: 0000-0002-1117-196X AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. FAU - Dincer, Emre AU - Dincer E AUID- ORCID: 0000-0003-1429-3206 AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. FAU - Ozalkaya, Elif AU - Ozalkaya E AUID- ORCID: 0000-0002-0992-1493 AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. FAU - Karatekin, Guner AU - Karatekin G AUID- ORCID: 0000-0001-7112-0323 AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260625 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Retrospective Studies MH - Infant, Newborn MH - *Infant, Small for Gestational Age/growth & development MH - Female MH - Male MH - *Growth Charts MH - *Fetal Growth Retardation/classification/diagnosis MH - *Infant, Premature/growth & development MH - Logistic Models MH - Gestational Age PMC - PMC13560381 OTO - NOTNLM OT - Extrauterine Growth Restriction OT - Fenton Growth Chart OT - Growth Charts OT - INTERGROWTH-21st OT - Infant, Very Premature OT - Small for Gestational Age COIS- Declarations. Ethics approval and consent to participate: Retrospective data collection was approved by the Clinical Research Ethics Committee of Zeynep Kamil Women and Children's Diseases Training and Research Hospital (Decision No. 93, Date: 21 April 2021). The updated Fenton-2025 reanalysis for the current manuscript was approved by the Zeynep Kamil Hospital Non-Interventional Research Ethics Committee (Decision No. 26, Date: 25 February 2026). The study was conducted in accordance with the Declaration of Helsinki. Owing to the retrospective nature of the updated reanalysis and the use of previously recorded hospital data, separate informed consent to participate was not required, as stated in the ethics application approved by the Zeynep Kamil Hospital Non-Interventional Research Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:50 MHDA- 2026/09/10 05:36 PMCR- 2026/06/25 CRDT- 2026/06/25 23:55 PHST- 2026/04/22 00:00 [received] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/09/10 05:36 [medline] PHST- 2026/06/26 00:50 [pubmed] PHST- 2026/06/25 23:55 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12887-026-07215-5 [pii] AID - 7215 [pii] AID - 10.1186/s12887-026-07215-5 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 25;26(1):855. doi: 10.1186/s12887-026-07215-5. PMID- 42350989 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - The hidden bias of missing data: multiple imputation reveals geographic disparities and nutrition-WASH synergy as drivers of childhood diarrhea in Nigeria- a cross-sectional analysis of 33,924 children. LID - 10.1186/s12887-026-07206-6 [doi] LID - 861 AB - OBJECTIVE: To investigate the determinants of childhood diarrhea in Nigeria, examining socio-economic, geographic, nutritional, and WASH factors, while systematically comparing Multiple Imputation by Chained Equations (MICE) versus Complete Case Analysis (CCA) to demonstrate how missing data methods bias conclusions. METHODS: A secondary cross-sectional analysis was conducted using the latest Nigerian Demographic and Health Survey (2018 NDHS) data on 33,924 under-5 children. The primary outcome was a caregiver-reported diarrhea incidence. Independent predictors were identified using multivariable logistic regression. Robustness was tested by sensitivity analyses through comparison between MICE, CCA and testing principal results under Missing Not at Random (MNAR) assumptions. Multi-dimensional risk heatmaps and correlation networks illustrated interactive risks. RESULTS: Diarrhea prevalence was 12.0%. Profound geo-economic and geographical disparities were uncovered; residing in the North-East was the strongest risk factor (aOR = 2.61), while wealth and maternal education demonstrated protective associations. There was a very high synergistic interaction between poor nutrition and WASH, with combined high-risk categories having the greatest prevalence of diarrhea (15.4%). Intake of eggs had a strong protective association (aOR = 0.87) that persisted under MNAR models. Sensitivity analyses revealed CCA-generated biased estimates, masking protective effects of education and inducing spurious risks for vitamin A and fruit consumption. CONCLUSION: Childhood diarrhea in Nigeria is driven by a complex interplay of interacting factors. Effective control requires a mix of integrated, multi-sectoral interventions involving WASH, nutrition, and poverty concurrently, focusing on high-burden zones. Methodologically, advanced management of missing data is critical to produce valid evidence. CI - (c) 2026. The Author(s). FAU - Ashaolu, Joseph Opeolu AU - Ashaolu JO AD - Institute for Global Health Innovations, Duy Tan University, 550000, Da Nang, Viet Nam. AD - Faculty of Medicine, Duy Tan University, Viet Nam, 550000, Da Nang, Viet Nam. FAU - Kaisi, Lydia Amin AU - Kaisi LA AD - Department of Public health, China Medical University, Taichung, Taiwan. FAU - Alabi, Gbenga Oluwaseyi AU - Alabi GO AD - Forestry and Agriculture Biotechnology Institute (FABI), University of Pretoria, Pretoria, South Africa. FAU - Esther, Omoyajowo A AU - Esther OA AD - Department of Biochemistry, Dominion University, Ibadan, Nigeria. FAU - Sylvain, Y M AU - Sylvain YM AD - National institute of Public Health, Centre de recherche en Sante de Nouna (CrSN), Nouna, Burkina Faso. sylvinsome@yahoo.fr. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Nigeria/epidemiology MH - *Diarrhea/epidemiology/etiology MH - Male MH - Female MH - Infant MH - Child, Preschool MH - Prevalence MH - Risk Factors MH - Bias MH - Socioeconomic Disparities in Health MH - Secondary Data Analysis MH - *Nutritional Status MH - Incidence MH - Health Surveys PMC - PMC13563736 OTO - NOTNLM OT - Childhood Diarrhea OT - Missing Data OT - Nigeria OT - Nutrition-WASH Synergy OT - Socio-economic Disparities COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki (World Medical Association). The study also employed the use of data extraction (secondary analysis) of an already collected dataset, and the survey personnel obtained ethical approval from the National Ethic Committee of the Federal Ministry of Health Abuja, Nigeria and ICF International, Rockville, MD, USA. Informed consent was obtained from study participants prior to participation in the survey. Permission to use and analyze the data set was obtained by registering the study on the Demographic and Health Survey (DHS) website. Competing interests: The authors declare no competing interests. Conflict of interest: The authors declare no conflicts of interest. EDAT- 2026/06/26 04:10 MHDA- 2026/09/11 05:36 PMCR- 2026/06/25 CRDT- 2026/06/25 23:55 PHST- 2026/01/08 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/11 05:36 [medline] PHST- 2026/06/26 04:10 [pubmed] PHST- 2026/06/25 23:55 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12887-026-07206-6 [pii] AID - 7206 [pii] AID - 10.1186/s12887-026-07206-6 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 25;26(1):861. doi: 10.1186/s12887-026-07206-6. PMID- 42350907 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260625 IS - 1742-7843 (Electronic) IS - 1742-7835 (Linking) VI - 139 IP - 2 DP - 2026 Aug TI - Association Between Urinary Heavy Metals and Developmental Disorders in Children Aged 6-15 Years: A Study Based on the NHANES Database. PG - e70266 LID - 10.1111/bcpt.70266 [doi] AB - This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2018, enrolling a total of 4525 children and adolescents aged 6-15 years. Weighted logistic regression, weighted quantile sum (WQS) regression and quantile g-computation (qgcomp) models were applied to explore the associations between nine urinary heavy metals (UHMs) and developmental disorders (DDs). After full covariate adjustment, urinary lead (Pb) (OR = 1.30, 95% CI: 1.10-1.54) and urinary antimony (Sb) (OR = 1.41, 95% CI: 1.18-1.69) were found to be positively correlated with DDs. Combined exposure models further identified a positive joint relationship between the mixture of UHMs and DDs, with Pb and Sb serving as the major contributing components. Sensitivity analyses that defined DDs solely based on receipt of special education or early intervention services yielded consistent findings. Given the limitations inherent to the cross-sectional design, single-spot urine sampling and heterogeneous outcome definitions, the present findings can only demonstrate correlational relationships, and further longitudinal investigations are required for conclusive validation. CI - (c) 2026 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd. FAU - Liao, Yanping AU - Liao Y AD - Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, Fujian, China. FAU - Zhan, Lingling AU - Zhan L AD - Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, Fujian, China. FAU - Li, Hong AU - Li H AUID- ORCID: 0009-0004-1125-7079 AD - Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, Fujian, China. LA - eng PT - Journal Article PL - England TA - Basic Clin Pharmacol Toxicol JT - Basic & clinical pharmacology & toxicology JID - 101208422 RN - 0 (Metals, Heavy) RN - 2P299V784P (Lead) RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - *Metals, Heavy/urine MH - Adolescent MH - Nutrition Surveys MH - Female MH - Male MH - *Developmental Disabilities/urine/epidemiology MH - United States/epidemiology MH - *Environmental Exposure/adverse effects/analysis MH - Lead/urine MH - Databases, Factual MH - *Environmental Pollutants/urine OAB - Exposure to heavy metals may raise the risk of developmental disorders (DDs) in children. This study analysed urine samples from over 4500 US children aged 6-15 for nine metals. Higher levels of lead and antimony were linked to greater odds of having a DD. When considering all metals together, lead and antimony were the main drivers of increased risk. The link with lead was stronger in boys, while antimony affected both boys and girls. Reducing exposure to these metals could help prevent DDs, especially in vulnerable groups like boys. OABL- eng OTO - NOTNLM OT - NHANES OT - children OT - developmental disorders OT - urinary heavy metals EDAT- 2026/06/26 00:47 MHDA- 2026/06/27 04:10 CRDT- 2026/06/25 23:34 PHST- 2026/06/10 00:00 [revised] PHST- 2026/03/20 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 00:47 [pubmed] PHST- 2026/06/25 23:34 [entrez] AID - 10.1111/bcpt.70266 [doi] PST - ppublish SO - Basic Clin Pharmacol Toxicol. 2026 Aug;139(2):e70266. doi: 10.1111/bcpt.70266. PMID- 42350848 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1865-5785 (Electronic) IS - 1868-9256 (Print) IS - 1865-5785 (Linking) VI - 19 IP - 1 DP - 2026 Jun 25 TI - Diagnostic potential of Q-flags (RBC agglutination? and fragments?) in beta thalassemia carriers: a comparative analysis with nutritional anemias. LID - 10.1007/s12308-026-00710-9 [doi] LID - 35 AB - INTRODUCTION: Beta thalassemia carriers have hereditary anemia marked by ineffective erythropoiesis and hemolysis, leading to considerable variation in red blood cell (RBC) morphology. Automated hematology analyzers equipped with quality flags (Q-flags) can identify abnormal RBC populations. This study evaluates the diagnostic performance of two Q-flags (RBC Agglutination? and Fragments?) in differentiating beta thalassemia from common nutritional anemias. METHODS: This study was conducted on complete blood count (CBC) data from 37 patients with beta thalassemia carriers and 3317 patients with nutritional anemias, including 2780 with iron deficiency anemia, 478 with vitamin B12 deficiency, and 59 with folate deficiency. All data were obtained using Sysmex hematology analyzers. The Shapiro-Wilk test assessed the distribution of data, and group comparisons were performed using the Mann-Whitney U test. Receiver operating characteristic (ROC) curve analysis was employed to determine the cutoff values of Q-flag parameters. RESULTS: Patients with beta thalassemia demonstrated significantly lower values for Q-flag (RBC Agglutination?) and significantly higher values for Q-flag (Fragments?) compared to those with nutritional anemias. The median (interquartile range) for Q-flag (RBC Agglutination?) was 40.0 (40.0-50.0), and for Q-flag (Fragments?) it was 40.0 (20.0-60.0). Significant differences were also noted in routinely reported hematological indices such as MCV, MCH, MCHC, and MicroR%. ROC analysis revealed that cutoff value of 60.0 for Q-flag (RBC Agglutination?) and 20.0 for Q-flag (Fragments?) had reasonable sensitivity and specificity for distinguishing beta thalassemia from nutritional anemias. CONCLUSION: There is a possibility that both Q-flags demonstrate strong discriminatory ability for beta thalassemia carriers in comparison to nutritional anemias and serve as useful screening tools within routine hematology workflows. CI - (c) 2026. The Author(s). FAU - Shaikh, Muhammad Shariq AU - Shaikh MS AUID- ORCID: 0000-0003-2938-7416 AD - Section of Hematology & Transfusion Medicine, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Stadium Road, Karachi, 74800, Pakistan. muhammad.shariq@aku.edu. FAU - Nunes, Joao Marcelo Martins AU - Nunes JMM AD - Sysmex Asia Pacific, R & D Centre, 9 Tampines Grande, Asia Green, #06-18, Singapore, 528735, Singapore. FAU - Kono, Mari AU - Kono M AD - Sysmex Asia Pacific, R & D Centre, 9 Tampines Grande, Asia Green, #06-18, Singapore, 528735, Singapore. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260625 PL - Germany TA - J Hematop JT - Journal of hematopathology JID - 101491976 SB - IM MH - Humans MH - *beta-Thalassemia/blood/diagnosis/genetics MH - Female MH - Male MH - Adult MH - Adolescent MH - Anemia, Iron-Deficiency/blood/diagnosis MH - Heterozygote MH - *Erythrocytes, Abnormal/pathology MH - *Anemia/diagnosis/blood MH - Young Adult MH - Child PMC - PMC13303572 OTO - NOTNLM OT - Anemia diagnostics OT - Beta thalassemia carrier OT - Hematology analyzer flagging OT - RBC variation COIS- Declarations. Ethical approval: This study used anonymized laboratory data obtained from routine clinical testing. In accordance with institutional policy, ethical approvals and exemptions were obtained from the Aga Khan University Ethical Review Committee (AKU ERC #2024-9824-29,527) and the Sysmex Ethics Review Committee (Sysmex ERC #2024-025). In addition, approval was granted by the Research Ethics Committee of the National Bioethics Committee for Research, National Institute of Health (Ref No. 4-87/NBC-1138/23/471) for retrospective analyses not involving patient contact or identifiable information. Informed consent: Not applicable. Consent for publication: Not applicable. Conflict of interest: Joao Marcelo Martins Nunes and Mari Kono are employed in Sysmex group. EDAT- 2026/06/26 00:44 MHDA- 2026/06/27 04:10 PMCR- 2026/06/25 CRDT- 2026/06/25 23:32 PHST- 2025/12/10 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 00:44 [pubmed] PHST- 2026/06/25 23:32 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1007/s12308-026-00710-9 [pii] AID - 710 [pii] AID - 10.1007/s12308-026-00710-9 [doi] PST - epublish SO - J Hematop. 2026 Jun 25;19(1):35. doi: 10.1007/s12308-026-00710-9. PMID- 42349796 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 226 DP - 2026 Nov 1 TI - Why we eat: Development and validation of a 7-factor Motivations for Eating Profile (MEP-7). PG - 108699 LID - S0195-6663(26)00261-8 [pii] LID - 10.1016/j.appet.2026.108699 [doi] AB - Understanding why people eat is crucial for the prevention and management of overeating and obesity, but existing psychometric tools typically assess a narrow set of motivational constructs. The current study developed a comprehensive, theory-driven questionnaire from a recently validated framework of eating behaviour traits derived from 18 existing eating behaviour scales and evaluated its psychometric properties and external validity. Study 1 used a structured review panel of n = 30 adults and applied item response theory to a survey of n = 1279 adults, to select items from widely used eating behaviour scales and novel items for 'pleasure' and 'health'. Study 2 surveyed a UK-representative adult sample (1042 females, 968 males) to perform exploratory (n = 1005) and confirmatory (n = 1005) factor analyses. Internal consistency, measurement invariance, and associations between latent motives and body mass index (BMI), self-reported weight change, lifetime weight loss attempts, eating rate and physical activity were examined. Exploratory and confirmatory factor analyses revealed a seven-factor, 28-item model (reactive eating, restricted eating, negative emotional eating, positive emotional eating, homeostatic eating, eating for pleasure and eating for health) with good model fit (CFI = 0.993, SRMR = 0.045, RMSEA = 0.046) and good to excellent reliability (omegaT = 0.77-0.93). Scalar invariance by sex, age, and education was supported. Latent motives showed theoretically consistent associations with external outcomes: higher reactive and negative emotional eating related to higher BMI and faster eating rate; homeostatic and health motives related to lower BMI and higher physical activity. The 7-Factor Motivation for Eating Profile (MEP-7) provides a brief, psychometrically robust profile of seven eating behaviour motivations with evidence of predictive validity. The MEP-7 supports research and clinical phenotyping and may inform behaviour change strategies for weight management. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Dakin, Clarissa AU - Dakin C AD - School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: psccda@leeds.ac. FAU - Finlayson, Graham AU - Finlayson G AD - Appetite Control and Energy Balance Research Group (ACEB), School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, UK. FAU - James Stubbs, R AU - James Stubbs R AD - Appetite Control and Energy Balance Research Group (ACEB), School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20260625 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - *Motivation MH - Male MH - *Feeding Behavior/psychology MH - Adult MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Psychometrics MH - Body Mass Index MH - Emotional Eating MH - Factor Analysis, Statistical MH - Middle Aged MH - Young Adult MH - United Kingdom MH - *Eating/psychology MH - Obesity/psychology MH - Exercise/psychology MH - Adolescent MH - Pleasure OTO - NOTNLM OT - Eating behaviour traits OT - Factor analysis OT - Item response theory OT - Motivations for eating OT - Psychometrics OT - Weight management COIS- Declaration of competing interest Pr. James Stubbs and Dr Clarissa Dakin declare that they consult for Slimming World UK through the University of Leeds. Slimming World were not involved in the analysis or interpretation of this articles. No other authors declare a conflict of interest. EDAT- 2026/06/26 00:47 MHDA- 2026/08/08 00:40 CRDT- 2026/06/25 19:32 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/08/08 00:40 [medline] PHST- 2026/06/26 00:47 [pubmed] PHST- 2026/06/25 19:32 [entrez] AID - S0195-6663(26)00261-8 [pii] AID - 10.1016/j.appet.2026.108699 [doi] PST - ppublish SO - Appetite. 2026 Nov 1;226:108699. doi: 10.1016/j.appet.2026.108699. Epub 2026 Jun 25. PMID- 42348754 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20261006 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jul 13 TI - An AI-Assisted Tool to Predict Continuous Glucose Monitor Adherence in Children With Type 1 Diabetes in Oman: Protocol for a Multiphase Mixed Methods Translational Study. PG - e99626 LID - 10.2196/99626 [doi] LID - e99626 AB - BACKGROUND: Type 1 diabetes mellitus (T1DM) in children requires sustained self-management to achieve glycemic targets. Continuous glucose monitoring (CGM) has transformed pediatric diabetes care; yet, adherence to device wear remains inconsistent. In May 2024, Oman launched a national initiative distributing CGMs to children with T1DM across all governorates, creating a real-world opportunity to study adherence determinants and to develop a locally validated AI-assisted predictive tool. OBJECTIVE: This multiphase translational research project aims to (1) characterize the population of Omani children with T1DM; (2) identify demographic, psychosocial, dietary, and physical activity correlates of optimal CGM use; (3) develop, train, and validate an AI-assisted behavioral predictive tool "OMNIdiasense" to forecast CGM adherence prior to device dispensing; and (4) pilot test the OMNIdiasense tool. METHODS: Three sequential, interlinked substudies will be conducted. Substudy 1 is a retrospective cohort analysis of routinely collected Al Shifa data for all children who received CGMs between July 2024 and February 2025, with glycemic, anthropometric, and laboratory outcomes compared at baseline and at >/=3 months. Outputs on adherence prevalence, and clinical predictors become the structured input layer for the proposed AI model. Substudy 2 is a cross-sectional, mixed methods study using face-to-face structured interviews with a randomly selected sample of children aged 10-18 years, classified as "CGM optimizers" (>/=6 days/week) or "CGM subusers" (<6 days/week or discontinued); responses across validated behavioral, stress, and dietary instruments are compared. Outputs are the psychosocial and behavioral feature set, qualitative themes, and effect sizes that drive feature selection for the AI model. Substudy 3 develops the AI tool (OMNIdiasense), comprising (1) a quasi-experimental single-arm pilot among 100 existing CGM subusers and (2) a parallel pilot randomized controlled trial (n=50; 25 intervention, 25 control) among newly diagnosed children, with assessments at baseline, 3, 6, and 12 months. The primary outcome is between-group difference in CGM adherence; secondary outcomes include hemoglobin A(1c), anthropometric, cardiovascular, and laboratory measures, and barriers to use. Reporting will follow SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2025 (interventional component), STROBE (Strengthening the Reporting of Observational Studies in Epidemiology; observational component), the CONSORT (Consolidated Standards of Reporting Trials) 2025 extension for pilot and feasibility trials, COREQ (Consolidated Criteria for Reporting Qualitative Research; qualitative component), and TRIPOD+AI (Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis + Artificial Intelligence; predictive model). RESULTS: The proposed AI tool is intended as a decision-support adjunct and not a gatekeeping mechanism for CGM access. CONCLUSIONS: To our knowledge, OMNIdiasense is the first AI tool in the Gulf Cooperation Council region to predict pediatric CGM adherence. By targeting behaviorally vulnerable patients before sensor distribution, OMNIdiasense is expected to support clinical benefit and reduce financial waste. TRIAL REGISTRATION: ISRCTN Registry ISRCTN15827616; https://doi.org/10.1186/ISRCTN15827616. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/99626. CI - (c)Thamra Al Ghafri, Saud Al Harthi, Asma Bait Ishaq, Huwaida Al Harthi, Maryam Al Muaini, Rahma Al-Ghadani, Ahmed Aljufaili, Mohamed Al Harb, Abdullah Al Saadi, Abdelhamid Abdessalem, Noushath Shaffi, Mohamed Ahmed, Said Jaboob, Nadia Al Maqbali, Moza Al-Shehhi, Talib Al Kalbani, Amal Al Shukaili, Jannat Al Harthi. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 13.07.2026. FAU - Al Ghafri, Thamra AU - Al Ghafri T AUID- ORCID: 0000-0002-4818-9565 AD - Directorate General of Health Services, Muscat, Oman. AD - Sultan Qaboos University, Muscat, Muscat, Oman. FAU - Al Harthi, Saud AU - Al Harthi S AUID- ORCID: 0000-0002-5457-4662 AD - Ministry of Health, Directorate General of Khaula Hospital, Muscat, Oman. FAU - Bait Ishaq, Asma AU - Bait Ishaq A AUID- ORCID: 0009-0009-7263-2692 AD - Directorate General of Health Services, Muscat, Oman. FAU - Al Harthi, Huwaida AU - Al Harthi H AUID- ORCID: 0009-0004-1540-5796 AD - Directorate General of Health Services, Muscat, Oman. FAU - Al Muaini, Maryam AU - Al Muaini M AUID- ORCID: 0009-0002-4555-427X AD - Ministry of Health, Ministry of Health, Batina, Oman. FAU - Al-Ghadani, Rahma AU - Al-Ghadani R AUID- ORCID: 0009-0008-1130-7987 AD - Ministry of Health, Ministry of Health, Batina, Oman. FAU - Aljufaili, Ahmed AU - Aljufaili A AUID- ORCID: 0009-0004-0480-3422 AD - Ministry of Health, Ministry of Health, Sharqiyah, Oman. FAU - Al Harb, Mohamed AU - Al Harb M AUID- ORCID: 0009-0007-7035-2350 AD - Ministry of Health, Ministry of Health, Sharqiyah, Oman. FAU - Al Saadi, Abdullah AU - Al Saadi A AUID- ORCID: 0009-0007-8798-0353 AD - Ministry of Health, Ministry of Health, Sharqiyah, Oman. FAU - Abdessalem, Abdelhamid AU - Abdessalem A AUID- ORCID: 0000-0003-2950-2875 AD - Sultan Qaboos University, Muscat, Muscat, Oman. FAU - Shaffi, Noushath AU - Shaffi N AUID- ORCID: 0000-0001-9243-8402 AD - Sultan Qaboos University, Muscat, Muscat, Oman. FAU - Ahmed, Mohamed AU - Ahmed M AUID- ORCID: 0009-0000-9458-9087 AD - Ministry of Health, Ministry of Health, AlWosta, Oman. FAU - Jaboob, Said AU - Jaboob S AUID- ORCID: 0009-0009-6411-7244 AD - Ministry of Health, Ministry of Health, Dhofar, Oman. FAU - Al Maqbali, Nadia AU - Al Maqbali N AUID- ORCID: 0000-0002-9926-6452 AD - Ministry of Health, Ministry of Health, Aldhahira, Oman. FAU - Al-Shehhi, Moza AU - Al-Shehhi M AUID- ORCID: 0000-0002-1001-2043 AD - Ministry of Health, Ministry of Health, Musandam, Oman. FAU - Al Kalbani, Talib AU - Al Kalbani T AUID- ORCID: 0000-0003-4585-0992 AD - Ministry of Health, Ministry of Health, Buraimi, Oman. FAU - Al Shukaili, Amal AU - Al Shukaili A AUID- ORCID: 0009-0002-6884-6689 AD - Ministry of Health, Ministry of Health, Aldakhilyah, Oman. FAU - Al Harthi, Jannat AU - Al Harthi J AUID- ORCID: 0009-0007-4182-5462 AD - National University of Science and Technology, Sohar, Oman. LA - eng SI - ISRCTN/ISRCTN15827616 PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260713 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 RN - 0 (Blood Glucose) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Artificial Intelligence MH - Blood Glucose/analysis MH - *Blood Glucose Self-Monitoring MH - *Continuous Glucose Monitoring/methods MH - *Diabetes Mellitus, Type 1/blood/psychology MH - Oman MH - *Patient Compliance/statistics & numerical data MH - Retrospective Studies MH - Observational Studies as Topic PMC - PMC13408470 OTO - NOTNLM OT - adherence OT - adolescent OT - artificial intelligence OT - behavioral prediction OT - continuous glucose monitoring OT - machine learning OT - pediatric OT - type 1 diabetes. COIS- Conflicts of Interest: None declared. EDAT- 2026/06/26 04:10 MHDA- 2026/07/14 12:34 PMCR- 2026/07/13 CRDT- 2026/06/25 14:53 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/06/21 00:00 [revised] PHST- 2026/07/14 12:34 [medline] PHST- 2026/06/26 04:10 [pubmed] PHST- 2026/06/25 14:53 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - v15i1e99626 [pii] AID - 10.2196/99626 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jul 13;15:e99626. doi: 10.2196/99626. PMID- 42348623 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260629 IS - 2327-2228 (Electronic) VI - 109 IP - 7 DP - 2026 Jul 1 TI - An Open Pilot Trial of a Physical Activity (PA) Intervention Designed to Address Barriers Experienced by Hispanic and Black Mothers. PG - 18-26 AB - INTRODUCTION: Mothers, especially those with marginalized identities, often struggle to meet physical activity (PA) guidelines. We examined feasibility, acceptability, and preliminary efficacy of Moms on the Move (MOMs), a community-based PA promotion intervention targeting Hispanic and Black mothers delivered in partnership with a youth sports organization in Providence, RI. METHODS: Feasibility targets centered around enrollment (i.e., n>30 participants), retention (i.e., >80% of participants through follow-up), and assessment (i.e., collection of PA data from >80% of participants at multiple timepoints), while acceptability targets centered around participant satisfaction (i.e., >80% of participants being satisfied with the intervention). For preliminary efficacy, we assessed weekly minutes of moderate-to- vigorous intensity PA (MVPA) via 7-Day PA Recall (PAR) at baseline, intervention end (8 weeks), and follow-up (12 weeks), and examined within-person changes in MVPA over time using paired T-tests. Stratified analysis was used to examine differences between participants who were already meeting the national guideline of >150 minutes of MVPA per week at baseline and those who were not. RESULTS: We met recruitment (n=35) and retention (94%) targets but only collected PA data at multiple timepoints from 21 participants (64%). Most participants (94%) were satisfied with the intervention, all (100%) said they learned from the program, and all (100%) said they would recommend participation to a friend. Participants who were not meeting the MVPA guideline at baseline (n=12) reported an increase in MVPA at both intervention end (mean change: 110.27 minutes, Cohen's d: 0.89) and follow-up (mean change: 82.09 minutes, Cohen's d: 0.76). CONCLUSIONS: Findings around recruitment, retention, and participant satisfaction were promising, though assessing MVPA via the PAR, which requires a semi-structured interview, proved challenging. Nonetheless, the findings, which also showed that insufficiently active mothers had significantly higher levels of MVPA at intervention end and follow-up, support testing MOMs in a fully powered, randomized controlled trial. FAU - von Ash, Tayla AU - von Ash T AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. FAU - Gupta-Louis, Sugandha K AU - Gupta-Louis SK AD - Department of Psychology, Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY. FAU - O'Hagan, Belinda AU - O'Hagan B AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. FAU - Onu, Michael AU - Onu M AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. FAU - Dunsiger, Shira AU - Dunsiger S AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. FAU - Maxwell, Zoe AU - Maxwell Z AD - Weight Control and Diabetes Research Center, Brown University, Providence, RI. FAU - Alacron, Ashlie AU - Alacron A AD - Weight Control and Diabetes Research Center, Brown University, Providence, RI. FAU - Brown, Candace S AU - Brown CS AD - Department of Epidemiology and Com- munity Health, University of North Carolina, Charlotte, NC. FAU - Marcus, Bess H AU - Marcus BH AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. LA - eng PT - Journal Article DEP - 20260701 PL - United States TA - R I Med J (2013) JT - Rhode Island medical journal (2013) JID - 101605827 SB - IM MH - Humans MH - Pilot Projects MH - *Hispanic or Latino MH - Female MH - *Exercise MH - *Black or African American MH - *Mothers/psychology MH - *Health Promotion/methods MH - Adult MH - Feasibility Studies OTO - NOTNLM OT - community-based OT - mothers OT - physical activity OT - pilot OT - youth sports EDAT- 2026/06/26 00:53 MHDA- 2026/06/26 00:54 CRDT- 2026/06/25 13:44 PHST- 2026/06/26 00:54 [medline] PHST- 2026/06/26 00:53 [pubmed] PHST- 2026/06/25 13:44 [entrez] PST - epublish SO - R I Med J (2013). 2026 Jul 1;109(7):18-26. PMID- 42348608 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260811 IS - 1473-6519 (Electronic) IS - 1363-1950 (Linking) VI - 29 IP - 5 DP - 2026 Sep 1 TI - Pediatric and adolescent nutritional and metabolic assessment in the precision era. PG - 441-447 LID - 10.1097/MCO.0000000000001244 [doi] AB - PURPOSE OF REVIEW: To summarize recent methodological and technological advances in assessing nutritional and metabolic status among pediatric and adolescent populations, with emphasis on their translational value within precision and personalized nutrition. This review highlights how integrative, multi-omics, and digital approaches may complement the evaluation of body composition, dietary intake, metabolic profiling, and behavioral monitoring in youth. RECENT FINDINGS: Recent findings suggest that combining compositional imaging (DXA, 3D optical, ultrasound) with bioelectrical and omic biomarkers may improve multidimensional nutritional profiling. Digital dietary assessment, biosensors, and continuous glucose monitoring may enhance real-time dietary and metabolic characterization in selected research or clinical contexts. Moreover, machine-learning models and multi-omic integration show promise individualized risk prediction and adaptive feedback, although their clinical utility requires further validation. However, standardization of protocols and pediatric reference datasets remains a key challenge. SUMMARY: Nutritional and metabolic assessment in children and adolescents is progressively moving toward integrative frameworks that combine imaging, omics, and digital monitoring. These approaches may support more individualized and developmentally sensitive evaluations, but harmonization of protocols, ethical governance, accessibility, and pediatric reference datasets remain essential before broad clinical implementation. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid. AD - Ciencias de la Actividad Fisica y El Deporte, Escuela Universitaria de Osuna (Centro Adscrito a la Universidad de Sevilla), Osuna. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba. AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), RD21/0012/0008, Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0007), Instituto de Salud Carlos III, Madrid. FAU - Llorente-Cantarero, Francisco Jesus AU - Llorente-Cantarero FJ AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid. AD - Department of Specific Didactics, Faculty of Education, University of Cordoba, Cordoba, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid. LA - eng PT - Journal Article PT - Review DEP - 20260603 PL - England TA - Curr Opin Clin Nutr Metab Care JT - Current opinion in clinical nutrition and metabolic care JID - 9804399 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - Adolescent MH - *Nutrition Assessment MH - *Precision Medicine/methods MH - *Nutritional Status MH - Multiomics MH - Digital Health MH - Machine Learning MH - Biomarkers MH - Body Composition OTO - NOTNLM OT - dietary assessment OT - machine learning OT - multi-omics integration OT - pediatric nutrition OT - personalized intervention EDAT- 2026/06/26 00:43 MHDA- 2026/08/06 12:37 CRDT- 2026/06/25 13:44 PHST- 2026/08/06 12:37 [medline] PHST- 2026/06/26 00:43 [pubmed] PHST- 2026/06/25 13:44 [entrez] AID - 00075197-202609000-00004 [pii] AID - 10.1097/MCO.0000000000001244 [doi] PST - ppublish SO - Curr Opin Clin Nutr Metab Care. 2026 Sep 1;29(5):441-447. doi: 10.1097/MCO.0000000000001244. Epub 2026 Jun 3. PMID- 42347953 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20261010 IS - 1432-5195 (Electronic) IS - 0341-2695 (Linking) VI - 50 IP - 7 DP - 2026 Jul TI - Efficacy of scapular-focused rehabilitation protocol on shoulder function following Proximal Humeral Internal Locking System fixation for proximal humeral fractures: a randomized controlled trial. PG - 1661-1672 LID - 10.1007/s00264-026-06914-z [doi] AB - BACKGROUND: Proximal humeral fractures (PHFs) are a significant healthcare burden, representing the third most common osteoporotic fracture in older adults. Although open reduction and internal fixation (ORIF) with the Proximal Humeral Internal Locking System (PHILOS) provides a reliable rate of osseous union, postoperative complications such as shoulder stiffness and residual pain remain prevalent. Current rehabilitation protocols are predominantly glenohumeral-centric and often overlook fracture-associated scapular dyskinesis. This randomized controlled trial (RCT) aims to evaluate whether incorporating a systematic scapular control and stabilization program into standard postoperative rehabilitation yields superior outcomes after PHILOS fixation. METHODS: A single-centre, prospective RCT was conducted from June 1, 2023, to December 31, 2024. Sixty eligible patients (aged 18 to 80 years) with severely displaced two- or three-part PHFs were randomized (1:1) to a scapular-focused rehabilitation (SFR) group (n = 30) or a standard rehabilitation (SR) group (n = 30). Both groups attended supervised physiotherapy twice weekly for 12 weeks, with the SFR group receiving additional systematic scapular stabilization exercises. The primary outcome was the Constant-Murley score (CMS) at 12 months. Secondary outcomes included the Disabilities of the Shoulder, Arm, and Hand (DASH) score, the American Shoulder and Elbow Surgeons (ASES) score, the Shoulder Pain and Disability Index (SPADI), and visual analog scale (VAS) pain scores assessed at one, three, six and 12 months, along with EuroQol (EQ) scores, patient-reported satisfaction and radiographic evaluations (neck-shaft angle [NSA] and humeral head height [HHH]). RESULTS: Baseline characteristics were well balanced between the two cohorts. The SFR group had significantly higher adjusted mean CMS at 1 month (46.1 +/- 7.5 vs. 41.5 +/- 8.4; P = 0.039) and three months (63.4 +/- 9.6 vs. 57.2 +/- 9.1; P = 0.018) postoperatively than the SR group. Similarly, the SFR cohort had significantly superior DASH, ASES, SPADI pain, and VAS pain scores at one and three months (all P < 0.05). Furthermore, health-related quality of life, comprehensively evaluated via EQ-5D and EQ-VAS indices (P < 0.05), as well as patient-reported satisfaction metrics (P < 0.001), were markedly higher in the experimental cohort during the initial three months of intensive rehabilitation. However, these functional differences attenuated over time, with no statistically significant differences in CMS (P = 0.325) or secondary clinical outcomes at the 12-month final follow-up. Radiographic analysis revealed no significant intergroup differences in NSA or HHH at any time point (P = 0.600 and P = 0.462 at 3 months, respectively), indicating that the targeted intervention did not compromise construct stability. CONCLUSION: Incorporating systematic scapular-focused exercises into standard postoperative rehabilitation after PHILOS fixation for PHFs serves as a beneficial adjunct that significantly accelerates early functional recovery, reduces early postoperative pain, and improves patients' overall health utility and satisfaction in the early stages. These early gains are achieved without compromising fracture reduction or implant stability. Although long-term functional outcomes converge by 12 months, this accelerated recovery trajectory provides substantial clinical value by effectively reducing the burden of early postoperative disability in a vulnerable demographic. CI - (c) 2026. The Author(s) under exclusive licence to SICOT aisbl. FAU - Li, Linwei AU - Li L AD - Department of Trauma Center and Orthopedic Surgery, the First People's Hospital of Changzhou Affiliated with Soochow University, Changzhou, Jiangsu, China. FAU - Zhang, Jinlong AU - Zhang J AD - Department of Trauma Center and Orthopedic Surgery, the First People's Hospital of Changzhou Affiliated with Soochow University, Changzhou, Jiangsu, China. FAU - Zong, Lujie AU - Zong L AD - Department of Trauma Center and Orthopedic Surgery, the First People's Hospital of Changzhou Affiliated with Soochow University, Changzhou, Jiangsu, China. FAU - Tan, Chunye AU - Tan C AD - Department of Trauma Center and Orthopedic Surgery, the First People's Hospital of Changzhou Affiliated with Soochow University, Changzhou, Jiangsu, China. FAU - Huang, Zhihui AU - Huang Z AD - Department of Trauma Center and Orthopedic Surgery, the First People's Hospital of Changzhou Affiliated with Soochow University, Changzhou, Jiangsu, China. FAU - Ma, Wenming AU - Ma W AD - Department of Trauma Center and Orthopedic Surgery, the First People's Hospital of Changzhou Affiliated with Soochow University, Changzhou, Jiangsu, China. FAU - Zhao, Yiwen AU - Zhao Y AD - Department of Trauma Center and Orthopedic Surgery, the First People's Hospital of Changzhou Affiliated with Soochow University, Changzhou, Jiangsu, China. zyw3362@suda.edu.cn. FAU - Chen, Yi AU - Chen Y AD - Department of Trauma Center and Orthopedic Surgery, the First People's Hospital of Changzhou Affiliated with Soochow University, Changzhou, Jiangsu, China. chenyi19910525@163.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20260625 PL - Germany TA - Int Orthop JT - International orthopaedics JID - 7705431 SB - IM MH - Humans MH - Female MH - *Scapula MH - *Shoulder Fractures/surgery/rehabilitation MH - Male MH - Treatment Outcome MH - Aged MH - Middle Aged MH - Prospective Studies MH - Aged, 80 and over MH - *Fracture Fixation, Internal/rehabilitation/methods MH - Adult MH - Range of Motion, Articular MH - Young Adult MH - Shoulder Joint/physiopathology MH - Adolescent MH - Recovery of Function OTO - NOTNLM OT - PHILOS OT - Proximal humeral fractures OT - Randomized controlled trial OT - Rehabilitation OT - Scapular stabilization COIS- Declarations. Ethical approval: This research was approved by the Ethics Committee of the First People's Hospital of Changzhou. Competing interests: The authors declare no competing interests. EDAT- 2026/06/25 16:09 MHDA- 2026/07/27 12:36 CRDT- 2026/06/25 11:13 PHST- 2026/04/19 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/27 12:36 [medline] PHST- 2026/06/25 16:09 [pubmed] PHST- 2026/06/25 11:13 [entrez] AID - 10.1007/s00264-026-06914-z [pii] AID - 10.1007/s00264-026-06914-z [doi] PST - ppublish SO - Int Orthop. 2026 Jul;50(7):1661-1672. doi: 10.1007/s00264-026-06914-z. Epub 2026 Jun 25. PMID- 42347433 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2305-6304 (Electronic) IS - 2305-6304 (Linking) VI - 14 IP - 6 DP - 2026 Jun 20 TI - Storage-Dependent Changes in Microplastic-Associated Recoverable Residues in Yogurt Containing Bifidobacterium longum subsp. infantis. LID - 10.3390/toxics14060535 [doi] LID - 535 AB - Microplastics (MPs) are increasingly detected in dairy products, raising food-safety concerns. Their behavior in complex food matrices and interactions with probiotic microorganisms remain poorly understood. This exploratory study evaluated storage-dependent changes in operationally defined, digestion-resistant recoverable residues in yogurt containing Bifidobacterium longum subsp. infantis (ATCC 15697). Yogurt samples were prepared with polypropylene (PP), polyethylene (PE), and polystyrene (PS), individually and in combination, and analyzed over 21 days of refrigerated storage. Gravimetric values served as relative, operational indicators of recoverable residues-not validated absolute polymer masses-while polymer identity was qualitatively confirmed by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). B. longum subsp. infantis remained viable throughout storage (6.3-8.2 log(10) CFU/g). All MP-containing groups showed consistent storage-associated decreases in recoverable residue fractions, greatest in PP, followed by PE and PS; probiotic-free controls remained stable. Polymer-specific Py-GC/MS signals were detectable at all time points. Because polymer identity was retained and the workflow was not validated for absolute recovery, findings are interpreted as storage-associated changes in extractability, filterability, and/or residue recovery-not as polymer degradation, mineralization, or biological removal. These in vitro observations are limited to the yogurt matrix and do not support extrapolation to livestock exposure, human dietary risk, or farm-to-fork transfer. Within these limits, the findings provide a preliminary, hypothesis-generating perspective on probiotic-microplastic interactions in fermented dairy products. FAU - Akkemik, Yasin AU - Akkemik Y AUID- ORCID: 0000-0002-9086-0324 AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu 37100, Turkiye. FAU - Ozcan, Sedat AU - Ozcan S AUID- ORCID: 0000-0001-9235-4049 AD - Department of Veterinary, Menemen Vocational School, Izmir Bakircay University, Izmir 35660, Turkiye. FAU - Dogan, Veysel AU - Dogan V AD - Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu 37100, Turkiye. FAU - Gokmen, Sedat AU - Gokmen S AD - Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu 37100, Turkiye. FAU - Tufekci, Enis Fuat AU - Tufekci EF AUID- ORCID: 0000-0001-5051-2694 AD - Department of Basic Medical Sciences, Faculty of Medicine, Kastamonu University, Kastamonu 37100, Turkiye. FAU - Erat, Salih AU - Erat S AUID- ORCID: 0000-0003-4413-6041 AD - Department of Veterinary, Menemen Vocational School, Izmir Bakircay University, Izmir 35660, Turkiye. LA - eng GR - BBAP.2024.007/Izmir Bakircay University/ PT - Journal Article DEP - 20260620 PL - Switzerland TA - Toxics JT - Toxics JID - 101639637 PMC - PMC13307711 OTO - NOTNLM OT - Bifidobacterium longum subsp. infantis OT - Py-GC/MS OT - dairy food safety OT - exploratory study OT - microplastics OT - probiotic-microplastic interactions OT - recoverable residue OT - yogurt COIS- The authors declare no conflicts of interest. EDAT- 2026/06/25 12:38 MHDA- 2026/06/25 12:39 PMCR- 2026/06/20 CRDT- 2026/06/25 09:55 PHST- 2026/05/04 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/25 12:39 [medline] PHST- 2026/06/25 12:38 [pubmed] PHST- 2026/06/25 09:55 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - toxics14060535 [pii] AID - toxics-14-00535 [pii] AID - 10.3390/toxics14060535 [doi] PST - epublish SO - Toxics. 2026 Jun 20;14(6):535. doi: 10.3390/toxics14060535. PMID- 42347082 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2571-841X (Electronic) IS - 2571-841X (Linking) VI - 9 IP - 2 DP - 2026 May 28 TI - Predictive Analysis of Extubation Failure in the Paediatric Intensive Care Unit in Bloemfontein, South Africa. LID - 10.3390/reports9020169 [doi] LID - 169 AB - Background: Extubation failure (EF) is a significant complication, and it is associated with increased mortality, prolonged hospital stays and extended mechanical ventilation (MV). Determining reliable predictors of EF could improve the clinical decision-making and outcomes. Objectives: Determine the outcomes and predictors of EF in a paediatric intensive care unit (PICU) and develop predictive models using machine learning algorithms. Methods: A retrospective cohort study (n = 824) was conducted in two PICUs in participants who underwent planned extubation (January 2018-December 2022). Demographic characteristics, clinical parameters, ventilator setting, laboratory findings and extubation outcomes were collected. Univariate and multivariate analysis were performed to identify significant predictors of EF. Six machine learning algorithms-Logistic Regression (LR), Artificial Neural Network (ANN), Extreme Gradient Boosting (XGBoost), Random Forest (RF), Support Vector Machine (SVM) and Decision Tree (DT)-were developed and validated for prediction of EF. Results: The overall EF rate was 231 (28%). Multivariate analysis identified a mechanical ventilation for a duration of 3 days or more (aOR 4.49, 95% CI 3.24-6.57, p < 0.001), use of neuromuscular blockade (aOR 1.32, 95% CI 1.07-1.63, p = 0.009), and administration of vasopressors (aOR 1.57, 95% CI 1.24-2.01, p < 0.001) as significant independent predictors of EF. The ANN and LR models demonstrated the highest performance with AUCROC of 0.87 +/- 0.04 and 0.86 +/- 0.02, respectively. Conclusions: Extubation failure was common in our setting (28%) compared to other studies. Days of ventilation, undernutrition, use of neuromuscular blockade, use of vasopressors or inotropes and CNS comorbidity were associated with EF. The main cause of EF was upper airway obstruction. FAU - Buankuna, Mbaya AU - Buankuna M AD - Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, Free State, South Africa. FAU - Sempa, Joseph B AU - Sempa JB AD - Department of Biostatistics, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, Free State, South Africa. FAU - Khaliq, Olive P AU - Khaliq OP AD - Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, Free State, South Africa. FAU - Pienaar, Michael A AU - Pienaar MA AUID- ORCID: 0000-0001-6427-0278 AD - Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, Free State, South Africa. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - Reports (MDPI) JT - Reports (MDPI) JID - 101757880 PMC - PMC13306389 OTO - NOTNLM OT - extubation failure OT - intensive care OT - mechanical ventilation OT - paediatrics COIS- The authors declare no conflicts of interest. EDAT- 2026/06/25 12:38 MHDA- 2026/06/25 12:39 PMCR- 2026/05/28 CRDT- 2026/06/25 09:53 PHST- 2026/02/13 00:00 [received] PHST- 2026/03/31 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/25 12:39 [medline] PHST- 2026/06/25 12:38 [pubmed] PHST- 2026/06/25 09:53 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - reports9020169 [pii] AID - reports-09-00169 [pii] AID - 10.3390/reports9020169 [doi] PST - epublish SO - Reports (MDPI). 2026 May 28;9(2):169. doi: 10.3390/reports9020169. PMID- 42346830 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 2 DP - 2026 Jun 5 TI - Virtual Reality-Supported Speech Therapy in Children with Developmental Language Disorder: A Randomized Controlled Trial. LID - 10.3390/medsci14020291 [doi] LID - 291 AB - BACKGROUND/OBJECTIVES: Digital technologies are increasingly explored as complementary tools in speech and language therapy for children with neurodevelopmental disorders. However, evidence on virtual reality-based interventions for children with developmental language disorder (DLD) remains limited. This study aimed to evaluate the effects of a Virtual Reality Rehabilitation System (VRRS)-based language intervention combined with standard speech therapy in preschool children with DLD. Secondary objectives included assessing the feasibility, usability, and safety of the VRRS-integrated intervention. METHODS: A randomized controlled pilot study was conducted in preschool children diagnosed with DLD. Participants were allocated to an experimental group receiving VRRS-based language intervention integrated with conventional therapy or to a control group receiving standard speech therapy alone. Both groups attended two 60 min sessions per week for six months. Clinical language outcomes were assessed at baseline (T0) and post-intervention (T1). Feasibility was evaluated through adherence and retention rates, usability through a therapist-completed questionnaire, and safety through monitoring of adverse events during sessions. RESULTS: All participants in the experimental group completed the intervention (100% retention). No adverse events were observed. Therapists reported good usability of the VRRS system, highlighting ease of exercise customization, intuitive monitoring of progress, and good integration into routine therapy. CONCLUSIONS: VRRS-based activities integrated into conventional speech therapy appear feasible, safe, and well accepted in preschool children with DLD. Further controlled studies with larger samples are needed to confirm these findings. TRIAL REGISTRATION: ClinicalTrials.gov (NCT07438639). FAU - De Domenico, Carmela AU - De Domenico C AUID- ORCID: 0009-0007-8868-8485 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - La Fauci, Margherita AU - La Fauci M AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Mancuso, Noemi AU - Mancuso N AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Caputo, Mariarita AU - Caputo M AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Di Cara, Marcella AU - Di Cara M AUID- ORCID: 0000-0002-4275-4340 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Piccolo, Adriana AU - Piccolo A AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Fulgenzi, Alessia AU - Fulgenzi A AUID- ORCID: 0009-0000-4028-1407 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Borzelli, Daniele AU - Borzelli D AUID- ORCID: 0000-0002-9456-0177 AD - Laboratory of Physiology, Department of Translational Medicine, Universita del Piemonte Orientale, 28100 Novara, Italy. AD - Laboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy. FAU - Impallomeni, Caterina AU - Impallomeni C AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Tripodi, Emanuela AU - Tripodi E AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Calabro, Rocco Salvatore AU - Calabro RS AUID- ORCID: 0000-0002-8566-3166 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Quartarone, Angelo AU - Quartarone A AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Cucinotta, Francesca AU - Cucinotta F AUID- ORCID: 0000-0001-8477-7826 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. LA - eng SI - ClinicalTrials.gov/NCT07438639 GR - Ministero della Salute/ PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20260605 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Language Development Disorders/therapy/rehabilitation MH - Child, Preschool MH - Male MH - Female MH - *Virtual Reality MH - *Speech Therapy/methods MH - Pilot Projects MH - Language Therapy/methods MH - Treatment Outcome PMC - PMC13304140 OTO - NOTNLM OT - developmental language disorder OT - neurodevelopmental disorders OT - speech therapy intervention OT - virtual reality rehabilitation system COIS- The authors declare no conflicts of interest. EDAT- 2026/06/25 16:09 MHDA- 2026/06/25 16:10 PMCR- 2026/06/05 CRDT- 2026/06/25 09:45 PHST- 2026/03/24 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/25 16:10 [medline] PHST- 2026/06/25 16:09 [pubmed] PHST- 2026/06/25 09:45 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - medsci14020291 [pii] AID - medsci-14-00291 [pii] AID - 10.3390/medsci14020291 [doi] PST - epublish SO - Med Sci (Basel). 2026 Jun 5;14(2):291. doi: 10.3390/medsci14020291. PMID- 42346744 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 2 DP - 2026 May 28 TI - Skeletal Age Evaluation with BAUSport(TM) Ultrasound in Young Slovak Female Athletes and Non-Athletes-A Cross-Sectional Study. LID - 10.3390/jfmk11020215 [doi] LID - 215 AB - Background: Biological maturity assessment is increasingly discussed in youth sport because chronological age alone does not reflect inter-individual variation in growth and pubertal timing. Ultrasound-based systems such as BAUSport provide a radiation-free alternative to radiographic skeletal age assessment. This exploratory cross-sectional study examined skeletal age (SA) in Slovak female volleyball players, track-and-field athletes, and non-athletes using BAUSport, while acknowledging substantial age differences between groups. Methods: Eighty girls (55 non-athletes, 13 volleyball players, 12 track-and-field athletes; aged 6.85-14.41 years) underwent anthropometric measurement and skeletal age (SA) assessment with BAUSport. Chronological age (CA) was calculated as decimal age from birth date to measurement date. Groups were not age-matched; volleyball players were on average markedly older than the other groups. Skeletal maturity was categorized as early, on-time, or late using a +/-1.0-year SA-CA threshold. Menarche status was recorded as an indicator of pubertal development. Group differences were evaluated using chi-square or Fisher's exact tests as appropriate, while differences in SA and SA-CA according to menarche status were assessed using Welch's t-test. Results: Volleyball players were older (12.90 +/- 0.95 years) than non-athletes (10.22 +/- 2.40 years) and track-and-field athletes (8.47 +/- 1.51 years). They also demonstrated the largest mean SA-CA difference (+1.98 +/- 0.73 years). The distribution of maturity categories differed across groups (chi(2)(4) = 14.32, p = 0.006, Cramer's V = 0.30). Post-menarcheal girls exhibited significantly higher skeletal age and SA-CA values compared to pre-menarcheal girls. However, the substantial age disparity between groups represents a primary confounding factor and limits interpretation of sport-specific effects. Conclusions: This study demonstrates the practical application of BAUSport for rapid, radiation-free skeletal age assessment in youth. Differences according to menarche status support the biological relevance of skeletal maturity assessment. However, no valid between-group sport-specific inferences can be made because the groups were not age-matched and puberty is the dominant driver of skeletal maturation. Larger, age-matched studies are required before drawing conclusions regarding sport-specific selection patterns. FAU - Svabova Nee Uhrova, Petra AU - Svabova Nee Uhrova P AUID- ORCID: 0000-0001-7497-4359 AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University Bratislava, Ilkovicova 6, Mlynska dolina, 842 15 Bratislava, Slovakia. AD - National Sports Centre, Olympijske namestie 14290/1, 831 04 Bratislava, Slovakia. FAU - Cihova, Iveta AU - Cihova I AD - National Sports Centre, Olympijske namestie 14290/1, 831 04 Bratislava, Slovakia. AD - Department of Track and Field, Faculty of Physical Education and Sports, Comenius University Bratislava, Nabr. arm. gen. L. Svobodu 9, 814 69 Bratislava, Slovakia. FAU - Sotak, Michal AU - Sotak M AUID- ORCID: 0009-0000-2966-4597 AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University Bratislava, Ilkovicova 6, Mlynska dolina, 842 15 Bratislava, Slovakia. FAU - Falbova, Darina AU - Falbova D AUID- ORCID: 0000-0003-2672-0965 AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University Bratislava, Ilkovicova 6, Mlynska dolina, 842 15 Bratislava, Slovakia. FAU - Vorobelova, Lenka AU - Vorobelova L AUID- ORCID: 0009-0009-2211-1581 AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University Bratislava, Ilkovicova 6, Mlynska dolina, 842 15 Bratislava, Slovakia. FAU - Benus, Radoslav AU - Benus R AUID- ORCID: 0000-0001-5917-1689 AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University Bratislava, Ilkovicova 6, Mlynska dolina, 842 15 Bratislava, Slovakia. FAU - Bundova, Lucia AU - Bundova L AUID- ORCID: 0009-0006-7941-2121 AD - National Sports Centre, Olympijske namestie 14290/1, 831 04 Bratislava, Slovakia. AD - Department of Pre-Primary and Primary Education, Faculty of Education, Comenius University Bratislava, Soltesovej 4, 811 08 Bratislava, Slovakia. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13301617 OTO - NOTNLM OT - BAUSportTM OT - maturation timing OT - skeletal age OT - ultrasound OT - volleyball OT - youth athletes COIS- The authors declare that there is no conflict of interest regarding this manuscript. EDAT- 2026/06/25 19:09 MHDA- 2026/06/25 19:10 PMCR- 2026/05/28 CRDT- 2026/06/25 09:44 PHST- 2026/03/05 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/25 19:10 [medline] PHST- 2026/06/25 19:09 [pubmed] PHST- 2026/06/25 09:44 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - jfmk11020215 [pii] AID - jfmk-11-00215 [pii] AID - 10.3390/jfmk11020215 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 May 28;11(2):215. doi: 10.3390/jfmk11020215. PMID- 42346395 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2218-1989 (Print) IS - 2218-1989 (Electronic) IS - 2218-1989 (Linking) VI - 16 IP - 6 DP - 2026 Jun 14 TI - Discriminative Ability of TyG, TyG-WC, BAI, FGIR, and QUICKI Indexes in Identifying Metabolic Syndrome in a Pediatric Population with Obesity. LID - 10.3390/metabo16060415 [doi] LID - 415 AB - Background/Objectives: Pediatric obesity is closely associated with metabolic syndrome (MetS), a condition linked to increased cardiometabolic risk. Early identification of high-risk individuals remains challenging. This study aimed to evaluate the diagnostic performance of selected anthropometric, metabolic dysfunction and insulin resistance indexes for identifying MetS in children and adolescents with obesity. Methods: In this retrospective, cross-sectional, single-center study, 758 children and adolescents with obesity (mean age 14.8 +/- 2.1 years; 59.9% females) hospitalized for a body weight-reduction program were included. MetS was defined according to International Diabetes Federation criteria, in which central obesity is a mandatory diagnostic component. The triglyceride-glucose (TyG), TyG-waist circumference (TyG-WC), body adiposity index (BAI), fasting glucose-to-insulin ratio (FGIR), and quantitative insulin sensitivity check index (QUICKI) were calculated. Receiver operating characteristic curve analysis was used to assess their discriminative ability. Results: The prevalence of MetS was 27.8% and was significantly higher in males than females (34.9% vs. 23.1%, p < 0.0001). TyG and TyG-WC showed the best discriminative performance (AUC 0.75 and 0.76, respectively), although with only moderate sensitivity and specificity. FGIR and QUICKI demonstrated lower accuracy (AUC 0.64 and 0.63), whereas BAI showed no discriminative ability (AUC 0.48). These findings were consistent across sexes, although sex-specific differences in both MetS prevalence and optimal cut-off values were observed. Correlation analyses confirmed moderate associations between TyG-based indexes and MetS, whereas other indexes showed weaker relationships. Conclusions: In the present cohort of children and adolescents with obesity, TyG and TyG-WC showed the best performance in identifying MetS compared with the other evaluated indexes. However, their performance remained moderate, and the proposed cut-off values require validation in independent populations. These indexes may represent simple supportive screening and risk-stratification tools but should be used alongside comprehensive clinical assessment and established diagnostic criteria rather than as stand-alone diagnostic measures. FAU - Tamini, Sofia AU - Tamini S AUID- ORCID: 0000-0002-2503-5117 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Bondesan, Adele AU - Bondesan A AUID- ORCID: 0000-0002-9145-5400 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Caroli, Diana AU - Caroli D AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Frigerio, Francesca AU - Frigerio F AUID- ORCID: 0009-0007-1227-1747 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Sartorio, Alessandro AU - Sartorio A AUID- ORCID: 0000-0002-9620-4133 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. LA - eng GR - ricerca corrente/Ministry of Health/ PT - Journal Article DEP - 20260614 PL - Switzerland TA - Metabolites JT - Metabolites JID - 101578790 PMC - PMC13303531 OTO - NOTNLM OT - FGIR OT - MetS OT - QUICKI OT - TyG OT - TyG-WC OT - adolescents OT - children OT - metabolic syndrome OT - obesity OT - pediatric obesity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/25 19:09 MHDA- 2026/06/25 19:10 PMCR- 2026/06/14 CRDT- 2026/06/25 09:43 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/25 19:10 [medline] PHST- 2026/06/25 19:09 [pubmed] PHST- 2026/06/25 09:43 [entrez] PHST- 2026/06/14 00:00 [pmc-release] AID - metabo16060415 [pii] AID - metabolites-16-00415 [pii] AID - 10.3390/metabo16060415 [doi] PST - epublish SO - Metabolites. 2026 Jun 14;16(6):415. doi: 10.3390/metabo16060415. PMID- 42345641 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2543-6031 (Electronic) IS - 2451-4934 (Print) IS - 2451-4934 (Linking) VI - 94 IP - 3 DP - 2026 Jun 5 TI - Impact of Highly Effective CFTR Modulator Therapy on Physical Activity, Sleep, and Sinonasal Symptoms in Preschool Children with Cystic Fibrosis: A Prospective Single-Center Pilot Study. LID - 10.3390/arm94030036 [doi] LID - 36 AB - Background: Highly effective CFTR modulation with Elexacaftor/Tezacaftor/Ivacaftor (ETI) markedly improves clinical outcomes in people with cystic fibrosis (CF). Data on its effects on physical activity, sleep, sinonasal symptoms, and parent-perceived outcomes in preschool-aged children are limited. Methods: In this prospective, observational, single-center cohort study, ten children with cystic fibrosis (aged 2-6 years) and at least one CFTR variant eligible for ETI were included. Data were collected using wrist-worn Garmin vivofit Junior 2 activity trackers and standardized questionnaires one month before ETI initiation and at 1, 3, 6, and 12 months after start of ETI. Outcomes included step count, minutes of moderate-to-vigorous physical activity, sleep parameters, sinonasal symptoms, and parental perceptions. Results: ETI was well tolerated. Sweat chloride levels decreased significantly. Physical activity improved at 3 and 6 months (step count and active minutes/day; p < 0.05) but declined to near-baseline levels at 12 months. Parental assessments of physical and sporting performance showed sustained improvement. Sleep duration remained stable, with no changes in deep or light sleep phases or nighttime awakenings. Sinonasal symptoms remained low. Discussion & Conclusions: Preliminary findings of this exploratory pilot study show that improvement in physical activity after three and six months of ETI therapy might be attributable to seasonality, as therapy was started in winter months. No changes in sleep duration or sleep patterns are reassuring in this small cohort of young children with CF. ETI therapy was safe and well tolerated. Parental appraisal of their children's physical performance improved after start of ETI. Longitudinal, controlled studies involving larger cohorts are required to validate these findings and to account for potential confounding factors, such as age-dependent changes and individual and environmental factors such as seasonal variation. FAU - Schellhorn, Stella AU - Schellhorn S AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Schmidt, Hanna AU - Schmidt H AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Janda, Ales AU - Janda A AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Gulke, Doris AU - Gulke D AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Toth, Monika AU - Toth M AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Fabricius, Dorit AU - Fabricius D AUID- ORCID: 0000-0002-2019-8101 AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Bode, Sebastian F N AU - Bode SFN AUID- ORCID: 0000-0001-7217-3312 AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. LA - eng PT - Journal Article PT - Observational Study DEP - 20260605 PL - Switzerland TA - Adv Respir Med JT - Advances in respiratory medicine JID - 101697329 RN - 0 (Aminophenols) RN - 0 (Quinolones) RN - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator) RN - 0 (Pyrazoles) RN - 0 (Benzodioxoles) RN - 0 (Indoles) RN - 0 (Pyridines) RN - RRN67GMB0V (elexacaftor) RN - 8RW88Y506K (tezacaftor) RN - 0 (Drug Combinations) RN - 1Y740ILL1Z (ivacaftor) RN - 0 (Thiophenes) RN - 0 (Pyrrolidines) SB - IM MH - Humans MH - Pilot Projects MH - Prospective Studies MH - Child, Preschool MH - Female MH - Male MH - *Cystic Fibrosis/drug therapy/complications/physiopathology MH - Child MH - *Exercise MH - *Aminophenols/therapeutic use MH - *Quinolones/therapeutic use MH - *Cystic Fibrosis Transmembrane Conductance Regulator/genetics MH - *Pyrazoles/therapeutic use MH - *Benzodioxoles/therapeutic use MH - *Indoles/therapeutic use MH - *Pyridines/therapeutic use MH - *Sleep/drug effects MH - Drug Combinations MH - Thiophenes/therapeutic use MH - Pyrrolidines PMC - PMC13296162 OTO - NOTNLM OT - CFTR-modulator OT - actigraphy OT - activity OT - cystic fibrosis OT - preschool children OT - sinonasal symptoms OT - sleep OT - wearables COIS- The authors declare no conflict of interest. EDAT- 2026/06/25 12:38 MHDA- 2026/06/25 12:39 PMCR- 2026/06/05 CRDT- 2026/06/25 09:33 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/25 12:39 [medline] PHST- 2026/06/25 12:38 [pubmed] PHST- 2026/06/25 09:33 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - arm94030036 [pii] AID - arm-94-00036 [pii] AID - 10.3390/arm94030036 [doi] PST - epublish SO - Adv Respir Med. 2026 Jun 5;94(3):36. doi: 10.3390/arm94030036. PMID- 42344529 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 1178-2390 (Print) IS - 1178-2390 (Electronic) IS - 1178-2390 (Linking) VI - 19 DP - 2026 TI - Family Empowerment for Stunting Prevention in Children Aged 0-2 Years: A Concept Analysis. PG - 616138 LID - 10.2147/JMDH.S616138 [doi] LID - 616138 AB - BACKGROUND: Stunting in children aged 0-2 years remains a major global health challenge, particularly in low‑ and middle‑income countries, with long‑term consequences for growth and development. Although family empowerment is widely promoted as a strategy for stunting prevention, its conceptualization within stimulation, early detection, and family‑centered care remains fragmented. METHODS: Guided by Walker and Avant's concept analysis framework, this study systematically examined literature retrieved from PubMed, Scopus, and Google Scholar (July 2025). Studies were screened for relevance to family empowerment, caregiving, health literacy, and growth monitoring in the context of children aged 0-2 years. RESULTS: Twenty‑seven eligible studies were synthesized to refine the construct of family empowerment in stunting prevention. Across the reviewed literature, family empowerment was consistently conceptualized as a multidimensional process characterized by five interrelated attributes-reflective decision‑making, self‑efficacy, participation, health literacy integration, and resource mobilization-positioning families as active agents in growth monitoring, stimulation, and timely intervention during the first 1000 days of life. CONCLUSION: This analysis reframes family empowerment as a strategic, family‑centered pathway for stunting prevention. By advancing conceptual clarity within nursing and culturally diverse caregiving contexts, the findings inform practice and policy through the integration of empowerment indicators alongside growth monitoring and highlight priorities for future research focused on culturally responsive validation of empowerment measures. CI - (c) 2026 Sutini et al. FAU - Sutini, Titin AU - Sutini T AUID- ORCID: 0000-0003-1077-0992 AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. AD - Faculty of Nursing, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia. FAU - Rakhmawati, Windy AU - Rakhmawati W AUID- ORCID: 0000-0001-7173-4886 AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. FAU - Mediani, Henny Suzana AU - Mediani HS AUID- ORCID: 0000-0001-6960-3692 AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. FAU - Permatasari, Tria Astika Endah AU - Permatasari TAE AUID- ORCID: 0000-0001-9589-3814 AD - Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia. LA - eng PT - Journal Article PT - Review DEP - 20260618 PL - New Zealand TA - J Multidiscip Healthc JT - Journal of multidisciplinary healthcare JID - 101512691 PMC - PMC13290388 OTO - NOTNLM OT - child nutrition OT - concept analysis OT - early childhood OT - family empowerment OT - family-centre care OT - stunting prevention COIS- The authors declare no conflicts of interest in this work. EDAT- 2026/06/25 06:37 MHDA- 2026/06/25 06:38 PMCR- 2026/06/18 CRDT- 2026/06/25 04:40 PHST- 2026/04/11 00:00 [received] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/06/25 06:38 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 04:40 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 616138 [pii] AID - 10.2147/JMDH.S616138 [doi] PST - epublish SO - J Multidiscip Healthc. 2026 Jun 18;19:616138. doi: 10.2147/JMDH.S616138. eCollection 2026. PMID- 42344510 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 1662-5161 (Print) IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 20 DP - 2026 TI - Building an auxiliary diagnostic and treatment efficacy prediction model for adolescent depression using machine learning based on electroencephalography technology. PG - 1774822 LID - 10.3389/fnhum.2026.1774822 [doi] LID - 1774822 AB - BACKGROUND: Adolescent depression, characterized by high incidence rates and significant recurrence risks, has emerged as a major global public health concern. Current diagnosis relies predominantly on subjective questionnaires, lacking objective biomarkers and presenting challenges for early identification. Although exercise intervention is recommended as a safe and effective first-line non-pharmacological treatment, individual responses vary considerably. Approximately 30-40% of patients experience limited symptom improvement, necessitating reliable neurobiological markers to predict intervention response and enable precision exercise prescription. Resting-state electroencephalography (rs-EEG), with its non-invasive nature, low cost, and high temporal resolution, represents an ideal tool for identifying objective markers of depression. This study aims to construct a high-performance auxiliary diagnostic model for adolescent depression based on static and dynamic functional connectivity features of rs-EEG, combined with machine learning algorithms. It further seeks to identify neurophysiological biomarkers capable of predicting exercise intervention efficacy, thereby providing objective and practical technical support for early identification and individualized non-pharmacological interventions. METHODOLOGY: This study employed a machine learning framework combining diagnostic and predictive models. The diagnostic model aimed to identify depressed individuals among healthy adolescents (N = 155) and those with subclinical depression (N = 149), whilst the predictive model focused on the emotional response to a virtual reality-based exercise intervention within the same depressed cohort (N = 149), categorizing participants into high, moderate, and low responders. Six-minute resting-state EEG signals were collected, preprocessed, and segmented into 78 brain regions using the Schaefer template. These regions were then grouped into five core networks (sensory-motor, dorsal attention, salience, default mode, and central executive networks). Forty-five phase-locked functional connectivity features across the theta, alpha, and beta frequency bands were subsequently extracted. A three-stage feature selection method (random forest importance ranking, Pearson correlation redundancy removal, exhaustive search to determine optimal subsets) was employed to screen key neural biomarkers. Four classification models - logistic regression, support vector machines, random forest, and XGBoost - were constructed and compared. Ten-fold cross-validation and grid search were employed to optimize hyperparameters, with performance evaluated using accuracy, recall, precision, F1-score, and AUC-ROC. Finally, the SHAP framework was applied for model interpretability analysis, revealing the contributions and interactions of key brain network features. RESULTS: Diagnostic model: The XGBoost model demonstrated exceptional performance in distinguishing SCD patients from healthy controls (AUC of 0.994, accuracy of 96.7%). Core biomarkers primarily concentrated on connections within the dorsal attention network (DAN), salience network (SN), and sensorimotor network (SMN) across the beta and alpha frequency bands, with intra-DAN connections in the beta band contributing most significantly. SHAP interaction dependency analysis further revealed complex nonlinear interaction patterns that may underlie, including a "fork-collider" synergistic structure centered on beta-DAN and theta-SMN-DAN, cross-frequency inhibition of beta-DAN by alpha-SN, and dynamic gating of beta-DMN by alpha-SMN-DAN. The results of this study indicate that subclinical depression (ScD) manifests as a pattern of synergistic dysregulation involving multiple frequency bands and brain networks. In terms of predictive modeling, support vector machines (SVMs) performed best in predicting the response of ScD patients to exercise intervention, with baseline positive affect (PA) levels and functional connectivity between the somatosensory motor network (SMN) and the dorsal attentional network (DAN) in the beta-band identified as key predictors. Furthermore, the patterns of feature interactions revealed by the model provide a testable framework for understanding the underlying model-derived neurophysiological patterns of subclinical depression from the perspective of multi-frequency, multi-network dyssynchrony; however, these results should still be interpreted as statistical associations rather than direct evidence of biological causality. SHAP analysis revealed an interpretable integration pathway ("behavior-driven --> core coordination --> dynamic gating --> frequency band balance"), providing model-driven insights into the role of behavior-neural integration in personalized interventions. CONCLUSION: This study systematically elucidates for the first time the intricate model-derived neurophysiological patterns of subclinical depression at the multi-frequency brain network level. It confirms the substantial potential of EEG functional connectivity as an objective biomarker while providing an interpretable neurophysiological basis for the precise selection of exercise interventions. These findings deepen our understanding of the early pathophysiology of depression and lay a robust foundation for developing low-cost, non-invasive tools for early screening and personalized treatment decision-making. CI - Copyright (c) 2026 Peng, Chi, Yang, Ren, Li and Fan. FAU - Peng, Ting AU - Peng T AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Chi, Aiping AU - Chi A AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Yang, Jinghui AU - Yang J AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Ren, Yizhong AU - Ren Y AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Li, Yanru AU - Li Y AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Fan, Jing AU - Fan J AD - Shaanxi Vocational and Technical College, Xi'an, Shaanxi, China. LA - eng PT - Journal Article DEP - 20260609 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC13286898 OTO - NOTNLM OT - adolescents OT - depressive symptoms OT - diagnostic model OT - electroencephalography OT - machine learning OT - predictive model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/25 06:37 MHDA- 2026/06/25 06:38 PMCR- 2026/06/09 CRDT- 2026/06/25 04:39 PHST- 2025/12/24 00:00 [received] PHST- 2026/04/28 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/06/25 06:38 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 04:39 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - 10.3389/fnhum.2026.1774822 [doi] PST - epublish SO - Front Hum Neurosci. 2026 Jun 9;20:1774822. doi: 10.3389/fnhum.2026.1774822. eCollection 2026. PMID- 42344477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2691-3593 (Electronic) IS - 2691-3593 (Linking) VI - 7 IP - 2 DP - 2026 Jun TI - Patient-Reported Outcomes and Body Mass Index in Adolescents and Young Adults After Gender-Affirming Chest Surgery: A Single-Center Cross-Sectional Study. PG - e679 LID - 10.1097/AS9.0000000000000679 [doi] AB - OBJECTIVE: To assess the impact of body mass index (BMI) on patient-reported outcomes after gender-affirming chest surgery in adolescents. BACKGROUND: Despite most previous studies finding no association between BMI and patient-reported outcomes in adults undergoing gender-affirming chest surgery, BMI eligibility requirements remain widely used. Moreover, little data exists regarding the impact of BMI on these outcomes in adolescents. METHODS: A cross-sectional, patient-reported outcome survey study was conducted at a pediatric hospital from April to July 2024. Eligible individuals were at least 1-year postoperative from gender-affirming chest surgery. The primary outcome was the effect of BMI on scores from 7 validated patient-reported outcome measures, including BODY-Q Chest and Nipple, Gender Congruence and Life Satisfaction, Satisfaction with Decision, and Decision Regret Scale, compared between adolescent and young adult cohorts. RESULTS: Among 77 participants who completed the survey, 42 (54.5%) underwent surgery as adolescents and 35 (45.5%) as young adults. Patient-reported outcomes evaluating appearance satisfaction, psychosocial well-being, and decisional satisfaction were high, whereas decisional regret was low. Scores did not significantly differ between adolescent and young adult cohorts, and most patient-reported outcome measures were not significantly influenced by BMI. CONCLUSION: After gender-affirming chest surgery, both adolescents and young adults reported high appearance satisfaction, psychosocial well-being, and decisional satisfaction, along with low decisional regret. For the majority of patient-reported outcomes, these positive results were not associated with BMI, suggesting that gender-affirming chest surgery is associated with high quality of life for adolescents and young adults regardless of BMI. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, Inc. FAU - Haley, Caleb AU - Haley C AD - From the Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI. AD - National Clinician Scholars Program, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI. FAU - Younoszai, Maya AU - Younoszai M AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Roblee, Cole V AU - Roblee CV AD - Department of Surgery, Swedish Medical Center, Seattle, WA. FAU - Haugen, Peter AU - Haugen P AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Araya-Colvin, Justine AU - Araya-Colvin J AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Brydges, Hilliard T AU - Brydges HT AD - Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA. FAU - Nguyen, Alisha AU - Nguyen A AD - Elson S. Floyd College of Medicine, Washington State University, Spokane, WA. FAU - Tople, Tannon AU - Tople T AD - University of Minnesota Twin Cities School of Medicine, Minneapolis, MN. FAU - Faino, Anna V AU - Faino AV AD - Core for Biostatistics, Epidemiology and Analytics in Research, Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA. FAU - Gopalan, Maya AU - Gopalan M AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Eble, Danielle AU - Eble D AD - Division of Plastic Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR. FAU - Ettinger, Russell E AU - Ettinger RE AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. AD - Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA. FAU - Morrison, Shane D AU - Morrison SD AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. AD - Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA. AD - Department of Urology, University of Washington Medical Center, Seattle, WA. LA - eng PT - Journal Article DEP - 20260527 PL - United States TA - Ann Surg Open JT - Annals of surgery open : perspectives of surgical history, education, and clinical approaches JID - 101769928 PMC - PMC13290217 OTO - NOTNLM OT - adolescents OT - body mass index OT - gender-affirming surgery OT - obesity OT - patient-reported outcomes COIS- Disclosure: The authors declare that they have nothing to disclose. EDAT- 2026/06/25 06:36 MHDA- 2026/06/25 06:37 PMCR- 2026/05/27 CRDT- 2026/06/25 04:39 PHST- 2026/01/23 00:00 [received] PHST- 2026/04/25 00:00 [accepted] PHST- 2026/06/25 06:37 [medline] PHST- 2026/06/25 06:36 [pubmed] PHST- 2026/06/25 04:39 [entrez] PHST- 2026/05/27 00:00 [pmc-release] AID - AOSO-D-26-00020 [pii] AID - 10.1097/AS9.0000000000000679 [doi] PST - epublish SO - Ann Surg Open. 2026 May 27;7(2):e679. doi: 10.1097/AS9.0000000000000679. eCollection 2026 Jun. PMID- 42344264 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - The mediating role of perceived physical literacy in the relationship between physical activity and cardiorespiratory fitness among Spanish adolescents: the ENERGYCO Study. PG - 1823971 LID - 10.3389/fpubh.2026.1823971 [doi] LID - 1823971 AB - BACKGROUND: Physical literacy (PL) may help explain the variability in health benefits associated with physical activity (PA) during adolescence. However, evidence examining the mediating role of perceived PL in the relationship between PA and cardiorespiratory fitness (CRF) in adolescents is scarce. OBJECTIVE: To examine whether perceived PL mediates the association between PA and indirectly estimated CRF based on a field test in adolescents. METHODS: Cross-sectional analyses were conducted using baseline data from the ENERGY expenditure of COmmuting to school study (ENERGYCO), which included 273 Spanish adolescents (median: 14.3 years; IQR: 2.1; 46.9% girls in the full sample [n = 273] and 47.7% girls in the analytical sample [n = 262]), 262 of whom had complete data for PA and perceived PL. Perceived PL was assessed via the Spanish Physical Literacy Perception Instrument for Adolescents (S-PPLI; Cronbach's alpha = 0.85). PA was assessed via the Spanish Youth Activity Profile (YAP-S). CRF was assessed via the 20-m shuttle run test and estimated maximum oxygen consumption (VO(2)max). Associations were examined via Spearman correlations and mediation analyses adjusted for sex, years from peak height velocity, body mass index (BMI), and socioeconomic status. RESULTS: Mediation analyses showed a significant indirect effect of PA on VO(2)max through perceived PL (indirect effect = 0.61, 95% bias-corrected and accelerated confidence interval (BCa CI: 0.14-1.16), accounting for 54.2% of the total effect. In domain-specific analyses, communication with others (indirect effect = 0.38, 95% BCa CI: 0.05-0.77) and knowledge and understanding (indirect effect = 0.60, 95% BCa CI: 0.17-1.08) significantly mediated the PA-VO(2)max association, whereas no significant mediation was observed for the sense of self and self-confidence domain (indirect effect = 0.27, 95% BCa CI: -0.08 to 0.68). CONCLUSION: Perceived PL mediated the association between PA and CRF in adolescents. These findings support an indirect pathway linking PA to aerobic fitness through perceived PL, although causal inferences cannot be drawn because of the cross-sectional design. CI - Copyright (c) 2026 Valle-Munoz, Jaakkola, Lopez-Gil and Villa-Gonzalez. FAU - Valle-Munoz, Victor Manuel AU - Valle-Munoz VM AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Jaakkola, Timo AU - Jaakkola T AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco, Chile. FAU - Villa-Gonzalez, Emilio AU - Villa-Gonzalez E AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. LA - eng PT - Journal Article DEP - 20260609 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Cardiorespiratory Fitness/physiology/psychology MH - Female MH - Spain MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - *Exercise/psychology/physiology MH - *Health Literacy/statistics & numerical data PMC - PMC13287042 OTO - NOTNLM OT - adolescence OT - cardiorespiratory fitness OT - health OT - physical activity OT - physical literacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/25 06:37 MHDA- 2026/06/25 06:38 PMCR- 2026/06/09 CRDT- 2026/06/25 04:37 PHST- 2026/03/05 00:00 [received] PHST- 2026/05/02 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/25 06:38 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 04:37 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1823971 [doi] PST - epublish SO - Front Public Health. 2026 Jun 9;14:1823971. doi: 10.3389/fpubh.2026.1823971. eCollection 2026. PMID- 42344116 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Heroes in motion - a six-year quality report and patient evaluation of a real-world exercise therapy program in pediatric oncology. PG - 1819559 LID - 10.3389/fped.2026.1819559 [doi] LID - 1819559 AB - INTRODUCTION: Rising survival rates in pediatric oncology underscore the importance of interventions that support short- and long-term bio-psycho-social health. Exercise therapy is now recognized as a key component of tertiary prevention and provides survival benefits. In 2020, the "Heroes in Motion" (HIM) program was established at the Department of Pediatric Hematology and Oncology in Freiburg to provide exercise interventions for patients and their families. This real-world service-based evaluation summarizes six years of program implementation, monitoring, and quality improvement, including patient- and parent-reported satisfaction data. METHODS: This multi-method evaluation integrates (a) quantitative data on exercise therapy details combined with structured program documentation and continuous process monitoring (2020-2025) and (b) findings from two satisfaction surveys conducted in 2020 and 2025. RESULTS: A total of 457 patients (age range: 1-24 years) participated in the HIM program over six years. During the evaluation period, 3.860 inpatient and 813 outpatient sessions were completed. Participation covered diverse diagnoses, with increasing family involvement following the introduction of the family-centered outpatient exercise program in 2023. Satisfaction remained consistently high, with 74% (n = 14) in 2020 and 81% (n = 13) in 2025 reporting being very satisfied. Participants highlighted individualized care, motivation, and perceived bio-psycho-social benefits. Across all age groups, demand for more frequent sessions and improved exercise facilities (e.g., an exercise room) was consistently expressed. DISCUSSION: The HIM program proved feasible, safe, and well accepted in a real-world pediatric oncology setting. Ongoing structural development and increasing family involvement emphasize the relevance of exercise therapy within supportive care. Future efforts will focus on establishing a multimodal, family-centered program as part of routine clinical practice. CI - (c) 2026 Ohnmacht, Kunder, Benz, Feuchtinger and Puzik. FAU - Ohnmacht, Carolin AU - Ohnmacht C AD - Department of Pediatric Hematology and Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Kunder, Alina AU - Kunder A AD - Department of Pediatric Hematology and Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Benz, Sina AU - Benz S AD - Department of Sport and Sport Science, University of Freiburg, Freiburg, Germany. FAU - Feuchtinger, Tobias AU - Feuchtinger T AD - Department of Pediatric Hematology and Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Puzik, Alexander AU - Puzik A AD - Department of Pediatric Hematology and Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. LA - eng PT - Journal Article DEP - 20260609 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13286956 OTO - NOTNLM OT - exercise therapy OT - family-centered OT - patient satisfaction OT - pediatric oncology OT - program implementation OT - supportive care COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/25 06:36 MHDA- 2026/06/25 06:37 PMCR- 2026/06/09 CRDT- 2026/06/25 04:35 PHST- 2026/02/27 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/25 06:37 [medline] PHST- 2026/06/25 06:36 [pubmed] PHST- 2026/06/25 04:35 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - 10.3389/fped.2026.1819559 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 9;14:1819559. doi: 10.3389/fped.2026.1819559. eCollection 2026. PMID- 42343872 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260717 IS - 1651-2006 (Electronic) IS - 1401-7431 (Linking) VI - 60 IP - 1 DP - 2026 Dec TI - A novel risk score based on exercise capacity to predict prognosis in adults with congenital heart disease. PG - 2690782 LID - 10.1080/14017431.2026.2690782 [doi] AB - BACKGROUND: Exercise capacity (EC) is a key prognostic indicator in adults with congenital heart disease (ACHD), closely associated with all-cause mortality. Thus, EC may serve a valuable tool for risk-stratification in ACHD. We propose a novel risk score incorporating EC, age, and lesion complexity to improve mortality risk prediction in ACHD. METHODS: This observational study utilized data from the Swedish National Register of Congenital Heart Disease. Adults aged 18 to 60 years who had completed at least one bicycle ergometer exercise test were included. EC was classified according to percentage of predicted capacity (% ECpred): normal (>70%), moderately impaired (50-70%), severely impaired (<50%). Patients were followed for ten years or until death. Odds ratios for mortality were used to derive a 5-point risk-score to estimate 10-year mortality, with the following point allocation: % ECpred 50-70 = 1 point, <50% = 2 points; age 25-40 years = 1 point, 40-60 years = 2 points; moderate/severe lesion complexity = 1 point. Internal validation of risk score resulted in a median AUC of 0.72 for training data, and 0.70 for test data. RESULTS: In total, 1,525 patients (mean age 31.1 +/- 11.8 years; 44% women) were included, where 104 deaths occurred during follow-up. Risk scores ranged from 0 to 5, corresponding to 10-year mortality rates of 1%, 3%, 5%, 10%, 18%, and 34%, respectively. CONCLUSION: A simple risk score incorporating exercise capacity, age, and congenital heart lesion complexity can effectively stratify ACHD patients to 10-year risk of all-cause mortality following an exercise test. FAU - Dalman-Skogby, Sandra AU - Dalman-Skogby S AD - Department of Diagnostics and Intervention, Umea Universitet, Umea, Sweden. AD - Region Vastra Gotaland, Sahlgrenska University Hospital, Children's Heart Center, Gothenburg, Sweden. FAU - Wiklund, Urban AU - Wiklund U AD - Department of Diagnostics and Intervention, Biomedical Engineering and Radiation Physics, Umea University, Umea, Sweden. FAU - Wikner, Anna AU - Wikner A AD - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden. FAU - Rinnstrom, Daniel AU - Rinnstrom D AD - Department of Diagnostics and Intervention, Umea Universitet, Umea, Sweden. FAU - Christersson, Christina AU - Christersson C AD - Department of Medical Sciences, Cardiology, Uppsala University, Sweden. FAU - Sorensson, Peder AU - Sorensson P AD - Department of Cardiology, Karolinska University Hospital, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. FAU - Trzebiatowska-Krzynska, Aleksandra AU - Trzebiatowska-Krzynska A AD - Department of Cardiology and Department of Medicine and Health Sciences, Linkoping University, Linkoping, Sweden. FAU - Mandalenakis, Zacharias AU - Mandalenakis Z AD - Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Hlebowicz, Joanna AU - Hlebowicz J AD - Department of Cardiology, Skane University Hospital, Lund, Sweden. AD - Department of Clinical Science, Lund University, Lund, Sweden. FAU - Sandberg, Camilla AU - Sandberg C AD - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden. AD - Department of Community Health and Rehabilitation, Umea University, Umea, Sweden. FAU - Johansson, Bengt AU - Johansson B AUID- ORCID: 0000-0003-0976-6910 AD - Department of Diagnostics and Intervention, Umea Universitet, Umea, Sweden. LA - eng PT - Journal Article PT - Observational Study DEP - 20260703 PL - England TA - Scand Cardiovasc J JT - Scandinavian cardiovascular journal : SCJ JID - 9708377 SB - IM MH - Humans MH - *Heart Defects, Congenital/physiopathology/mortality/diagnosis MH - *Exercise Tolerance MH - Adult MH - Risk Assessment MH - Female MH - Middle Aged MH - *Exercise Test MH - Predictive Value of Tests MH - Prognosis MH - Sweden MH - Male MH - Registries MH - Young Adult MH - Adolescent MH - Time Factors MH - Age Factors MH - Risk Factors MH - *Decision Support Techniques MH - Reproducibility of Results MH - Odds Ratio MH - Severity of Illness Index MH - Area Under Curve OTO - NOTNLM OT - Congenital OT - exercise test OT - exercise tolerance OT - heart defects OT - mortality OT - risk assessment EDAT- 2026/06/25 06:36 MHDA- 2026/07/03 16:10 CRDT- 2026/06/25 04:22 PHST- 2026/07/03 16:10 [medline] PHST- 2026/06/25 06:36 [pubmed] PHST- 2026/06/25 04:22 [entrez] AID - 10.1080/14017431.2026.2690782 [doi] PST - ppublish SO - Scand Cardiovasc J. 2026 Dec;60(1):2690782. doi: 10.1080/14017431.2026.2690782. Epub 2026 Jul 3. PMID- 42343553 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260911 IS - 1437-4331 (Electronic) IS - 1434-6621 (Linking) VI - 64 IP - 10 DP - 2026 Sep 25 TI - Performance of the European Kidney Function Consortium (EKFC) creatinine-based eGFR equation and other eGFR equations in a north European population. A multicentre study in Norway. PG - 2207-2215 LID - 10.1515/cclm-2026-0464 [doi] AB - OBJECTIVES: Accurate estimation of glomerular filtration rate (eGFR) is necessary for early detection and staging of chronic kidney disease (CKD), risk stratification, and guiding therapies that prevent complications and progression to advanced CKD. This study aimed to evaluate the performance of different eGFR equations in a large national cohort. METHODS: This multicentre study was conducted at six university hospitals in Norway. Retrospective data from patient's medical records from 2005 to 2024 for 5,552 adults and 2,981 children were used to validate several creatinine-based eGFR equations against measured GFR (mGFR) by Iohexol clearance. Performance was assessed using median bias and P30 accuracy (proportion of eGFR within +/-30 % of mGFR). RESULTS: The European Kidney Function Consortium (EKFC) creatinine-based eGFR equation outperformed the CKD-EPI 2009 and 2021, the Modification of Diet in Renal Disease (MDRD) in adults, the Schwarts bedside and the CKiD U25 equations in children >/=2 years and was comparable to the Lund-Malmo equation (LM) in adults. Both CKD-EPI equations had the lowest accuracy and were overestimating GFR in young people (<25 years) and elderly patients (>/=65 years). Replacing the CKD-EPI equations with the EKFC equation will result in lower eGFR values and a higher prevalence of CKD stages 3-5. Replacing the LM and MDRD with the EKFC equation will result in higher eGFR and a lower prevalence of CKD stages 3-5. CONCLUSIONS: The EKFC equation was overall the best suited creatinine-based eGFR equation for this Norwegian population from 2 years of age. Clinicians should be informed about clinical implications of shifting from other equations to the EKFC equation. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Averina, Maria AU - Averina M AUID- ORCID: 0000-0003-0195-1871 AD - Department of Laboratory Medicine, University Hospital of North Norway (UNN), Tromso, Norway. AD - Department of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromso, Norway. FAU - Brun, Atle AU - Brun A AD - Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway. FAU - Skadberg, Oyvind AU - Skadberg O AD - Laboratory of Clinical Biochemistry, Stavanger University Hospital, Stavanger, Norway. FAU - Lofblad, Lena AU - Lofblad L AD - Department of Medical Biochemistry, Laboratory Clinic, St. Olavs Hospital, Trondheim, Norway. AD - Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. FAU - Michaelsen, Anette AU - Michaelsen A AD - Department of Laboratory Medicine, University Hospital of North Norway (UNN), Tromso, Norway. FAU - Bergan, Stein AU - Bergan S AD - Department of Pharmacology, Oslo University Hospital, Oslo, Norway. FAU - Asberg, Anders AU - Asberg A AD - Department of Transplantation Medicine, Division of Surgery and Specialized Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway. AD - Department of Pharmacy, University of Oslo, Oslo, Norway. FAU - Lien, Mads Roald AU - Lien MR AD - Department of Medical Biochemistry, Laboratory Medicine Clinic, Oslo University Hospital, Oslo, Norway. FAU - Melsom, Toralf AU - Melsom T AD - Department of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromso, Norway. AD - Department of Nephrology, University Hospital of North Norway (UNN), Tromso, Norway. FAU - Eide, Ivar Anders AU - Eide IA AD - Department of Kidney Medicine, Akershus University Hospital, Oslo, Norway. AD - Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway. FAU - Keil, Thomas Morten AU - Keil TM AD - Department of Nuclear Medicine, St. Olavs Hospital, Trondheim, Norway. FAU - Skrunes, Rannveig AU - Skrunes R AD - Department of Medicine, Section of Nephrology, Haukeland University Hospital, Bergen, Norway. FAU - Nome, Ragnhild Veline AU - Nome RV AD - Department of Medical Biochemistry, Laboratory Medicine Clinic, Oslo University Hospital, Oslo, Norway. FAU - Vethe, Nils Tore AU - Vethe NT AD - Department of Pharmacology, Oslo University Hospital, Oslo, Norway. AD - Department of Pharmacy, University of Oslo, Oslo, Norway. FAU - Sithiravel, Cindhya AU - Sithiravel C AD - Department of Laboratory Medicine, Akershus University Hospital, Oslo, Norway. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260626 PL - Germany TA - Clin Chem Lab Med JT - Clinical chemistry and laboratory medicine JID - 9806306 RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - *Glomerular Filtration Rate MH - *Creatinine/blood MH - Norway MH - Female MH - Male MH - Adult MH - Child MH - Retrospective Studies MH - Aged MH - Middle Aged MH - Adolescent MH - *Renal Insufficiency, Chronic/diagnosis/physiopathology MH - Child, Preschool MH - Young Adult MH - *Kidney Function Tests MH - Aged, 80 and over OTO - NOTNLM OT - CKD-EPI OT - European Kidney Function Consortium (EKFC) OT - Iohexol OT - Lund-Malmo OT - Modification of Diet in Renal Disease (MDRD) OT - eGFR EDAT- 2026/06/25 06:35 MHDA- 2026/08/27 17:35 CRDT- 2026/06/25 01:03 PHST- 2026/03/24 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/08/27 17:35 [medline] PHST- 2026/06/25 06:35 [pubmed] PHST- 2026/06/25 01:03 [entrez] AID - cclm-2026-0464 [pii] AID - 10.1515/cclm-2026-0464 [doi] PST - epublish SO - Clin Chem Lab Med. 2026 Jun 26;64(10):2207-2215. doi: 10.1515/cclm-2026-0464. Print 2026 Sep 25. PMID- 42343262 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 24 TI - Agreement between random upper arm circumference and standard mid-upper arm circumference for identifying acute malnutrition among children aged 6-59 months in Southwest Ethiopia. LID - 10.1186/s12887-026-07125-6 [doi] LID - 851 AB - BACKGROUND: Mid-Upper Arm Circumference (MUAC) is a widely used, rapid, and low-cost anthropometric tool for community-based screening of acute malnutrition among children. However, accurate MUAC assessment requires identification of the midpoint of the upper arm and proper tape placement, which may contribute to inter-observer variability and inconsistencies in field measurements. Random Upper Arm Circumference (RUAC) has been proposed as a simpler alternative for community screening. Nevertheless, evidence regarding the agreement and validity of RUAC compared with standard MUAC for identifying wasting among Ethiopian children remains limited. Therefore, this study aimed to assess the concordance and validity of RUAC compared with MUAC in identifying wasting among children aged 6-59 months in Southwest Ethiopia. METHODS: A community-based cross-sectional study was conducted among 591 children aged 6-59 months in Southwest Ethiopia from June 2 to June 30, 2023. Participants were selected using simple random sampling from child registration lists used as the sampling frame. Paired RUAC and standard MUAC measurements were obtained from each child to assess agreement between the two methods. Children were classified as wasted using the MUAC cut-off value of < 12.5 cm, and RUAC was categorized using the same threshold. Data were analyzed using SPSS version 26. Agreement between RUAC and MUAC was evaluated using Cohen's Kappa for categorical measures and Bland-Altman analysis for continuous measurements. Diagnostic performance was assessed using sensitivity, specificity, positive predictive value, negative predictive value, and receiver operating characteristic (ROC) curve analysis. Assumptions for statistical analyses were checked before analysis. RESULTS: Among the participants, 61 (10.4%) children were classified as wasted using standard MUAC measurements. Significant agreement was observed between RUAC and standard MUAC classifications (kappa = 0.69; 95% CI: 0.60-0.79; p < 0.001). Using standard MUAC as the reference method, RUAC demonstrated a sensitivity of 81.6% (95% CI: 71.9%-89.0%) and specificity of 95.2% (95% CI: 93.1%-96.9%) for identifying wasting among children aged 6-59 months. The positive predictive value and negative predictive value of RUAC were 66.2% (95% CI: 55.0%-76.2%) and 97.8% (95% CI: 96.1%-98.9%), respectively. RUAC also demonstrated excellent diagnostic performance, with an area under the curve of 0.99 (95% CI: 0.98-0.99) for severe acute malnutrition and 0.94 (95% CI: 0.93-0.96) for moderate acute malnutrition. CONCLUSION: RUAC showed substantial agreement with standard MUAC and acceptable diagnostic performance for identifying wasting among children aged 6-59 months in Southwest Ethiopia. However, the evidence is limited to a single-site cross-sectional study, therefore, generalization beyond the study population is not justified. Further validation across different Ethiopian settings is recommended. CI - (c) 2026. The Author(s). FAU - Husen, Anuwar AU - Husen A AD - Masha Health Center, Sheka Zone, Southwest, Ethiopia. AD - Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. FAU - Berhane, Anteneh AU - Berhane A AUID- ORCID: 0000-0001-5078-8703 AD - School of Public Health, College of Health and Medical Sciences, Haramaya University, Harer, Ethiopia. antishaction@gmail.com. FAU - Teshome, Melese Sinaga AU - Teshome MS AD - Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. AD - Rehabilitation Research Centre (REVAL), Rehabilitation Sciences and Physiotherapy, Hasselt University, Wetenschapspark 7, Diepenbeek, 3590, Belgium. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260624 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Ethiopia MH - *Arm/anatomy & histology MH - Infant MH - Child, Preschool MH - Cross-Sectional Studies MH - Male MH - Female MH - *Anthropometry/methods MH - Reproducibility of Results MH - *Wasting Syndrome/diagnosis MH - Sensitivity and Specificity MH - Mass Screening/methods MH - Acute Disease PMC - PMC13560134 OTO - NOTNLM OT - Concordance OT - Correlation OT - Ethiopia OT - Mid-upper arm circumference OT - Random upper arm circumference OT - Validity OT - Wasting COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and its later amendments. Ethical approval was obtained from the Institutional Review Board of Jimma University, Institute of Health (reference number JUIH/IRB/501/23). Permission to conduct the study was also obtained from the relevant local health authorities. Written informed consent was obtained from the legal guardians of all participating children to data collection. Participation was entirely voluntary, and caregivers were informed of their right to withdraw from the study at any time without any consequences. Confidentiality of the collected information was ensured by assigning anonymized identification codes and restricting data access to the research team only. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/25 06:37 MHDA- 2026/09/10 05:37 PMCR- 2026/06/24 CRDT- 2026/06/25 00:25 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/09/10 05:37 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 00:25 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1186/s12887-026-07125-6 [pii] AID - 7125 [pii] AID - 10.1186/s12887-026-07125-6 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 24;26(1):851. doi: 10.1186/s12887-026-07125-6. PMID- 42343232 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260911 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Predicting the risk of unplanned cesarean delivery at admission to guide labor process management: a retrospective cohort study in Southwest China. LID - 10.1186/s12884-026-09470-x [doi] LID - 1001 AB - BACKGROUND: Following the implementation of the three-child policy in China, an increasing number of pregnant people prefer vaginal delivery over cesarean delivery. However, concerns about unplanned cesarean delivery during labor have increased the demand for a quantitative risk assessment tool. Therefore, developing a prediction model tailored for pregnant Chinese people is essential for assisting clinical decision-making. OBJECTIVE: This study aimed to identify risk factors associated with unplanned cesarean delivery during a trial of labor and to develop a predictive model for determining this risk at admission. METHODS: This single-center retrospective cohort study analyzed 1,532 pregnant people with a term, singleton, cephalic pregnancy without a history of uterine surgery who were admitted for a trial of labor (April-December 2021). Of these, 138 underwent unplanned cesarean delivery and 1,394 achieved vaginal delivery. Predictors were selected via LASSO regression from an initial set of 13 candidate variables and used to build a multivariate logistic nomogram. The model was assessed by its AUC, sensitivity, specificity, accuracy, positive predictive value, negative predictive value and calibration (Hosmer-Lemeshow test). Clinical utility was evaluated via decision curve analysis, and internal validation was conducted via 1,000 bootstrap repetitions. RESULTS: Eight variables were identified as significant predictors of delivery mode: maternal height, maternal BMI, history of vaginal delivery, Bishop score at admission, premature rupture of membranes, gestational age, complications, and estimated fetal weight. The predictive model achieved an AUC of 0.811 (95% CI: 0.774-0.848). The Hosmer-Lemeshow test indicated P = 0.513. Internal validation yielded a mean AUC of 0.804 and a Brier score of 0.071, demonstrating good discrimination and calibration. CONCLUSION: A nomogram-based predictive model was developed to assess the risk of unplanned cesarean delivery during trial of labor. This model provides a quantitative tool to guide clinicians in risk assessment and optimize labor management, potentially reducing complications associated with unplanned cesarean deliveries. CI - (c) 2026. The Author(s). FAU - Yang, Zhuo AU - Yang Z AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhang, Huicong AU - Zhang H AD - Whiting School of Engineering, Johns Hopkins University, Baltimore, USA. FAU - Zheng, Yue AU - Zheng Y AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Chang, Shufang AU - Chang S AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Sun, Jiangchuan AU - Sun J AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. sunjiangchuan@126.com. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Cesarean Section/statistics & numerical data MH - China MH - Adult MH - *Trial of Labor MH - Risk Factors MH - Risk Assessment/methods MH - Nomograms PMC - PMC13555930 OTO - NOTNLM OT - Clinical decision-making OT - LASSO regression OT - Nomogram OT - Predictive factors OT - Risk prediction model OT - Unplanned cesarean delivery OT - Vaginal trial of labor COIS- Declarations. Ethics approval and consent to participate: The Ethics Committee of the Second Affiliated Hospital of Chongqing Medical University approved this study and waived the need for informed consent because of the retrospective nature of this study. The research was conducted according to the ethical standard of the Helsinki Declaration, and the patient data were stored anonymously in a dedicated database. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/25 06:38 MHDA- 2026/09/09 07:07 PMCR- 2026/06/25 CRDT- 2026/06/25 00:24 PHST- 2025/09/09 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/25 06:38 [pubmed] PHST- 2026/06/25 00:24 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12884-026-09470-x [pii] AID - 9470 [pii] AID - 10.1186/s12884-026-09470-x [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 25;26(1):1001. doi: 10.1186/s12884-026-09470-x. PMID- 42342487 OWN - NLM STAT- Publisher LR - 20260727 IS - 1558-075X (Electronic) IS - 0146-0005 (Linking) VI - 50 IP - 5 DP - 2026 Aug TI - Standardizing outcome measures in preterm infant nutrition research: Use of anthropometry and body composition in the neonatal intensive care unit. PG - 152271 LID - S0146-0005(26)00060-1 [pii] LID - 10.1016/j.semperi.2026.152271 [doi] AB - Nutritional care and growth patterns in the neonatal intensive care unit (NICU) can impact lifelong health. Standardized measurement and reporting of growth outcomes are critical to improve the quality of information generated in research and population surveillance, facilitate comparisons and meta-analyses across individual studies, and strengthen the evidence used to generate clinical practice recommendations. Anthropometrics, specifically weight, length, and head circumference, are feasible and practical methods to monitor nutritional status. For research purposes, we recommend these anthropometrics be measured at birth (as a measure of fetal growth), 28 days old (to assess short-term growth), and 36 weeks postmenstrual age (PMA) (to determine the postnatal growth pattern in the NICU). We also encourage recording number of days to regain birthweight as a measure of short-term growth. Research publications should describe clearly the methods used to measure anthropometrics and reference curves used to calculate z-scores. Body composition is a complementary marker of nutritional status, but currently validated techniques have practical limitations in the NICU. When body composition tools are available, fat-free mass and fat mass should be measured at approximately 36 weeks PMA. We also describe key knowledge gaps and research priorities regarding growth patterns of preterm infants in the NICU. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Bell, Katherine A AU - Bell KA AD - Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: kbell7@bwh.harvard.edu. FAU - Calkins, Kara L AU - Calkins KL AD - Division of Neonatology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. FAU - Gollins, Laura A AU - Gollins LA AD - Department of Pediatrics, Division of Neonatology, Texas Children's Hospital, Houston, TX, USA. FAU - McNelis, Kera AU - McNelis K AD - Division of Neonatology, Department of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, GA, USA. FAU - Strobel, Katie M AU - Strobel KM AD - Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260624 PL - United States TA - Semin Perinatol JT - Seminars in perinatology JID - 7801132 SB - IM OTO - NOTNLM OT - Anthropometrics OT - Body composition OT - Growth OT - Infant OT - Malnutrition OT - Neonate OT - Preterm COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Katherine Bell reports a relationship with National Institute of Child Health and Human Development that includes: funding grants. Katherine Bell reports a relationship with Allen Foundation Inc that includes: funding grants. Katie Strobel reports a relationship with National Institute of Child Health and Human Development that includes: funding grants. Katie Strobel reports a relationship with Gerber Foundation that includes: funding grants. Katie Strobel reports a relationship with University of Washington Nutrition Obesity Research Center that includes: funding grants. Katie Strobel reports a relationship with Robert W. Anderson Endowed Fund that includes: funding grants. Katie Strobel reports a relationship with NEC Society that includes: funding grants. Kera McNelis reports a relationship with National Institute of Diabetes and Digestive and Kidney Diseases that includes: funding grants. Kera McNelis reports a relationship with ELGAN Study (site PI) that includes: funding grants and travel reimbursement. Kara Calkins reports a relationship with Fresenius Kabi USA LLC that includes: consulting or advisory and funding grants. Kara Calkins reports a relationship with Mead Johnson Nutrition Company that includes: consulting or advisory, funding grants, and speaking and lecture fees. Kara Calkins reports a relationship with Baxter International Inc that includes: consulting or advisory. Kara Calkins reports a relationship with Premier Research that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/25 00:33 MHDA- 2026/06/25 00:33 CRDT- 2026/06/24 21:55 PHST- 2026/05/11 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/25 00:33 [pubmed] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/24 21:55 [entrez] AID - S0146-0005(26)00060-1 [pii] AID - 10.1016/j.semperi.2026.152271 [doi] PST - ppublish SO - Semin Perinatol. 2026 Aug;50(5):152271. doi: 10.1016/j.semperi.2026.152271. Epub 2026 Jun 24. PMID- 42342393 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 24 TI - Can an active outdoor living initiative in kindergartens in two disadvantaged neighbourhoods increase physical activity among children? Findings from a within-subject design of the Happy Healthy Active Children initiative. PG - e120060 LID - 10.1136/bmjopen-2026-120060 [doi] LID - e120060 AB - OBJECTIVE: To investigate whether the Happy Healthy Active Children (HHAC) initiative increased children's time spent in different physical activity (PA) intensities in kindergartens located in disadvantaged neighbourhoods. DESIGN: A within-subject design, nested within the HHAC initiative, with children acting as their own controls. SETTING: Seven kindergartens in the adjacent disadvantaged neighbourhoods of Tingbjerg and Husum located in Copenhagen, Denmark. PARTICIPANTS: Children aged 3-5 years attending participating kindergartens. A total of n=51 children provided valid accelerometer data from at least one HHAC activity day and one regular kindergarten day. INTERVENTION: HHAC is a partnership-based initiative promoting active outdoor living through co-created activities centred around play, nature and cooking. In the kindergarten setting, activities were implemented one day per week over 10 weeks from the second half of 2023 to the first half of 2024. OUTCOME MEASURES: PA was measured using thigh-worn Axivity AX3 accelerometers over two 10-day periods during the initiative. Time spent in moderate-to-vigorous PA (MVPA), light PA and sedentary behaviour (SB) was compared between HHAC activity days and regular kindergarten days. RESULTS: Compared with regular days, children spent significantly more time in MVPA (8.6 min, p=0.002) and significantly less time in SB (9.2 min, p=0.007) on HHAC activity days. Play activity days showed the largest effects, with increased time spent in MVPA (13.2 min, p=0.002) and significantly less time spent in SB (19.2 min, p<0.001). No significant differences were observed for nature or cooking activities. CONCLUSION: The HHAC initiative, particularly its play-based activities, increased MVPA and reduced SB among children in kindergartens located in disadvantaged neighbourhoods. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Mullertz, Alberte Laura Oest AU - Mullertz ALO AUID- ORCID: 0009-0000-1153-5594 AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark alom@nexs.ku.dk. AD - Center for Clinical Research and Prevention, Frederiksberg Hospital, Frederiksberg, Denmark. FAU - Stage, Anna AU - Stage A AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. AD - Center for Clinical Research and Prevention, Frederiksberg Hospital, Frederiksberg, Denmark. FAU - Bloch, Paul AU - Bloch P AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Elsborg, Peter AU - Elsborg P AD - Center for Clinical Research and Prevention, Frederiksberg Hospital, Frederiksberg, Denmark. FAU - Termansen, Tina AU - Termansen T AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Stougard, Maria AU - Stougard M AUID- ORCID: 0000-0002-5573-4971 AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Herlev, Denmark. LA - eng PT - Journal Article DEP - 20260624 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Exercise MH - Male MH - Child, Preschool MH - Denmark MH - Female MH - *Health Promotion/methods MH - Accelerometry MH - Sedentary Behavior MH - Vulnerable Populations MH - Neighborhood Characteristics MH - Schools MH - Play and Playthings PMC - PMC13295874 OTO - NOTNLM OT - Child OT - Community-Based Participatory Research OT - Exercise OT - PUBLIC HEALTH OT - Primary Prevention COIS- Competing interests: None declared. EDAT- 2026/06/25 00:34 MHDA- 2026/06/25 00:35 PMCR- 2026/06/24 CRDT- 2026/06/24 21:23 PHST- 2026/06/25 00:35 [medline] PHST- 2026/06/25 00:34 [pubmed] PHST- 2026/06/24 21:23 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - bmjopen-2026-120060 [pii] AID - 10.1136/bmjopen-2026-120060 [doi] PST - epublish SO - BMJ Open. 2026 Jun 24;16(6):e120060. doi: 10.1136/bmjopen-2026-120060. PMID- 42341672 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260828 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 148 IP - 4 DP - 2026 Aug TI - Ketogenic diet therapy in pyruvate dehydrogenase deficiency: Global clinical practice from literature and survey data. PG - 110190 LID - S1096-7192(26)00473-7 [pii] LID - 10.1016/j.ymgme.2026.110190 [doi] AB - BACKGROUND: Pyruvate dehydrogenase deficiency (PDHD) is a rare mitochondrial disorder characterized by impaired carbohydrate metabolism, resulting in lactic acidosis and neurological dysfunction. Ketogenic diet therapy (KDT) is commonly used to bypass defective glucose metabolism; however, evidence guiding clinical practice remains limited. OBJECTIVE: To evaluate global clinical practice and published evidence regarding the use of KDT in children and young people with PDHD. METHODS: A combined literature review and international clinician survey were conducted. A systematic search identified studies reporting KDT use in PDHD. Two international surveys targeting registered dietitians and medical doctors collected data on clinical practice, diet initiation, monitoring, outcomes, and adverse effects. RESULTS: Forty studies describing 129 patients were identified, predominantly case reports or series. Survey responses were obtained from 41 dietitians (142 patients) and 14 physicians (64 patients) across multiple regions. All physician respondents supported referral for KDT at diagnosis regardless of genotype. Classical ketogenic diets were most commonly prescribed, though modified approaches were frequently used in clinical practice to improve feasibility and palatability. Target beta-hydroxybutyrate levels typically ranged between 2 and 4 mmol/L, although treatment was frequently individualized. Findings demonstrated improvements in seizure control, motor function, cognition, and quality of life. Adverse effects were primarily gastrointestinal. CONCLUSIONS: KDT is a widely used and generally well tolerated therapeutic strategy for PDHD across genotypes and age groups, with reported clinical benefits extending beyond seizure control. Clinical practice demonstrates variability, reflecting the limited high-quality evidence base. Development of standardized but flexible clinical guidelines and further longitudinal studies are needed to optimize patient outcomes. CI - Crown Copyright (c) 2026. Published by Elsevier Inc. All rights reserved. FAU - Madsen, Sarianne AU - Madsen S AD - UCSF Benioff Children's Hospital San Francisco, 1825 Fourth Street, Fifth Floor, 5A, San Francisco, CA 94158, USA. Electronic address: sarianne.madsen@ucsf.edu. FAU - Allender, Brooke AU - Allender B AD - The Royal Children's Hospital Melbourne, Lemington Rd, Parkville, VIC 3052, Australia. Electronic address: brooke.allender@rch.org.au. FAU - Blackford, Robyn AU - Blackford R AD - Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Box 29, Chicago, IL 60611, USA. Electronic address: rblackford@luriechildrens.org. FAU - Bollard, Tessa AU - Bollard T AD - Sydney Children's Hospital, Randwick, High Street, Randwick 2031, NSW, Australia. Electronic address: tessa.bollard@health.nsw.gov.au. FAU - Comerford, Annabel AU - Comerford A AD - Women's and Children's Health Network, 72 King William Road, North Adelaide, South Australia, Australia 5006. Electronic address: annabel.comerford@sa.gov.au. FAU - Johnson, Meredith L AU - Johnson ML AD - Children's Healthcare of Atlanta, 1001 Johnson Ferry Road NE, Atlanta, GA 30342, USA. Electronic address: meredith.johnson2@choa.org. FAU - Sinha, Rachel AU - Sinha R AD - The Royal Children's Hospital Melbourne, Lemington Rd, Parkville, VIC 3052, Australia. Electronic address: rachel.sinha@rch.org.au. FAU - Vanatta, Lisa AU - Vanatta L AD - Barrow Neurological Institute at Phoenix Children's, 1919 E. Thomas Road, Phoenix, AZ 85016, USA. Electronic address: lvanatta@phoenixchildrens.com. FAU - Whiteley, Victoria J AU - Whiteley VJ AD - Royal Manchester Children's Hospital, Oxford Road, Manchester M13 9WL, UK. Electronic address: victoria.whiteley@mft.nhs.uk. FAU - Schoeler, Natasha E AU - Schoeler NE AD - UCL Great Ormond Street Institute of Child Health, University College London, Gower Street, London WC1E 6BT, UK; Great Ormond Street Hospital for Children, Great Ormond St, London WC1N 3JH, UK. Electronic address: n.schoeler@ucl.ac.uk. CN - Ketogenic Dietitians Research Network LA - eng PT - Journal Article PT - Systematic Review DEP - 20260618 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Diet, Ketogenic/methods/adverse effects MH - *Pyruvate Dehydrogenase Complex Deficiency Disease/diet therapy MH - Surveys and Questionnaires MH - Treatment Outcome OTO - NOTNLM OT - Ketogenic diet therapy OT - Pyruvate dehydrogenase deficiency COIS- Declaration of competing interest SM received scholarship from Charlie Foundation to attend a conference. BA has received grants from Vitaflo and Metabolic Dietary Disorders Australia (NPO) to attend conferences. RB is a consultant to Nutricia North America and received scholarship from Charlie Foundation. TB received funding from Vitaflo Australia and Nutricia Advanced Medical Nutrition for accommodation and flights. AC has received grants from Nutricia Advanced Medical Nutrition and Vitaflo Australia. MLJ is a consultant to Ajinomoto Cambrooke and Nutricia North America and previously received scholarship from Charlie Foundation. RS has received grants from Nutricia Advanced Medical Nutrition and Vitaflo to attend conferences. LV previously received funding for research from Ajinomoto Cambrooke; Consultant to Nutricia North America; scholarship from Charlie Foundation; and honoraria from Keto Hope Foundation, Functional formularies, and Dr. Schaer. VJW has received grants from Nutricia Advanced Medical Nutrition, Vitaflo and Matthew's Friends Charity, and honoraria from Nutricia Advanced Medical Nutrition, Vitaflo, Dr. Schaer and Ajinomoto Cambrooke. NES was previously supported for a research post by Vitaflo. She has received grants from Nutricia Advanced Medical Nutrition, Vitaflo and Matthew's Friends Charity, and honoraria from Nutricia Advanced Medical Nutrition, Vitaflo, Dr. Schaer, Proveca and Grin Therapeutics Inc. EDAT- 2026/06/25 00:33 MHDA- 2026/07/16 12:40 CRDT- 2026/06/24 18:10 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/30 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/16 12:40 [medline] PHST- 2026/06/25 00:33 [pubmed] PHST- 2026/06/24 18:10 [entrez] AID - S1096-7192(26)00473-7 [pii] AID - 10.1016/j.ymgme.2026.110190 [doi] PST - ppublish SO - Mol Genet Metab. 2026 Aug;148(4):110190. doi: 10.1016/j.ymgme.2026.110190. Epub 2026 Jun 18. PMID- 42341584 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260909 IS - 1873-3573 (Electronic) IS - 0039-9140 (Linking) VI - 311 DP - 2027 Jan 1 TI - Determination of multiclass contaminants in colostrum by HS-SPME-GC-MS/MS: method development and validation. PG - 130203 LID - S0039-9140(26)00859-3 [pii] LID - 10.1016/j.talanta.2026.130203 [doi] AB - Breast milk is the primary source of nutrition for newborns. In addition to its well-established nutritional and immunological benefits, breast milk may also serve as a pathway for exposure to environmental contaminants, including pesticides and pharmaceuticals and personal care products (PPCPs). In this context, colostrum is especially relevant because it is the first food consumed by neonates, who are highly vulnerable to chemical stressors due to their physiological immaturity. Early-life exposure to these compounds may affect the development of the neurological, endocrine, and immune systems. Therefore, the determination of these contaminants in colostrum is essential to better understand maternal and neonatal exposure. This study aimed to develop a method employing HS-SPME and GC-MS/MS for the determination of multiclass contaminants in colostrum. Under standardized extraction conditions, a polyacrylate fiber was used. The LODs of the method ranged from 0.15 to 0.76 ng mL(-1,) and the LOQs ranged from 0.5 to 2.5 ng mL(-1). Accuracy and precision showed recovery values ranging from 43 to 120%, with RSD <22% for all analytes. Of the 26 analyzed samples, 10 contained at least one detected analyte, including five parabens and atrazine. The proposed method proved to be accurate, precise, solvent-free, and suitable for monitoring contaminants in colostrum. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Meireles, Anna Carolina Nickel AU - Meireles ACN AD - Post-graduate Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. FAU - Barbosa, Sergiane Caldas AU - Barbosa SC AD - Post-graduate Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. FAU - Kupski, Larine AU - Kupski L AD - Post-graduate Program in Food Engineering and Science, Escola de Quimica e Alimentos, Laboratorio de Micotoxinas e Ciencias de Alimentos (LAMCA), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. FAU - Arias, Jean Lucas de Oliveira AU - Arias JLO AD - Post-graduate Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. FAU - da Hora, Vanusa Pousada AU - da Hora VP AD - Post-graduate Program in Health Sciences, Faculdade de Medicina, Nucleo Interdisciplinar de Virologia e Imunologia (NIVI), Universidade Federal do Rio Grande, Rio Grande, RS, 96203-900, Brazil. FAU - Merib, Josias AU - Merib J AD - Post-graduate Program in Biosciences, Departamento de Farmacociencias, Grupo de Pesquisa em Preparo de Amostras e Cromatografia (GEPAC), Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, RS, 90050-170, Brazil. FAU - Primel, Ednei Gilberto AU - Primel EG AD - Post-graduate Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. Electronic address: eprimelfurg@gmail.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20260623 PL - Netherlands TA - Talanta JT - Talanta JID - 2984816R RN - 0 (Pesticides) RN - 0 (Parabens) RN - 0 (Environmental Pollutants) SB - IM MH - *Colostrum/chemistry MH - Humans MH - Gas Chromatography-Mass Spectrometry/methods MH - Female MH - Tandem Mass Spectrometry/methods MH - Solid Phase Microextraction/methods MH - Pesticides/analysis MH - Parabens/analysis MH - Limit of Detection MH - *Environmental Pollutants/analysis MH - Infant, Newborn OTO - NOTNLM OT - Biological sample OT - Emerging contaminants OT - Gas chromatography OT - Human milk OT - Solid-Phase Microextraction COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/25 00:34 MHDA- 2026/09/09 11:38 CRDT- 2026/06/24 18:08 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/06/25 00:34 [pubmed] PHST- 2026/06/24 18:08 [entrez] AID - S0039-9140(26)00859-3 [pii] AID - 10.1016/j.talanta.2026.130203 [doi] PST - ppublish SO - Talanta. 2027 Jan 1;311:130203. doi: 10.1016/j.talanta.2026.130203. Epub 2026 Jun 23. PMID- 42341365 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260928 IS - 1873-7811 (Electronic) IS - 0272-7358 (Linking) VI - 128 DP - 2026 Aug TI - Effects of mindfulness and mindful eating on food intake and appetite: a systematic review and meta-analysis. PG - 102780 LID - S0272-7358(26)00089-9 [pii] LID - 10.1016/j.cpr.2026.102780 [doi] AB - Mindfulness, mindful eating and intuitive eating practices are associated with healthier eating and lower body weight. However, experimental research in this area has shown mixed effects on food intake and theoretical accounts are underdeveloped. This systematic review and meta-analysis aimed to examine the effect of mindfulness, mindful eating and intuitive eating interventions on food intake and appetite (hunger and fullness) in adults and children and compare effects across different subgroups to investigate potential mechanisms of action. Five electronic databases (PsycINFO, MEDLINE, EMBASE, Web of Science and Scopus) were searched for studies that experimentally manipulated mindfulness and/or mindful eating and/or intuitive eating, included a non-mindfulness control group and measured food intake (kcal or grams or percentage consumed or number of pieces consumed) and/or appetite (using visual analogue scales). Forty-one articles assessing mindfulness and mindful eating interventions were included (no relevant intuitive eating interventions were identified). Random-effects meta-analyses showed that mindfulness/mindful eating reduced food intake (n = 46 studies, SMD = -0.24, 95% CI [-0.35, -0.12], p < 0.001) but had no statistically significant effect on appetite (n = 11 studies). There were no significant subgroup differences observed between studies with different settings, interventions or food intake measures. However, effect sizes were substantially larger in laboratory-based studies. Overall, findings indicate that mindfulness and mindful eating reliably reduce food intake in controlled settings, but currently there is no evidence they influence appetite. The review underscores the need for higher quality and more ecologically valid studies using sensitive, real-world measures of appetite and food intake, and further work to clarify the mechanisms of action underpinning the effects of mindfulness and mindful eating. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Ahmadyar, Khaleda AU - Ahmadyar K AD - Department of Psychology and Neuroscience, City St George's, University of London, London, UK. FAU - Zhang, Qing AU - Zhang Q AD - School of Psychological Science, University of Bristol, Bristol, UK. Electronic address: qing.zhang.2020@bristol.ac.uk. FAU - Ferriday, Danielle AU - Ferriday D AD - School of Psychological Science, University of Bristol, Bristol, UK; NIHR Bristol Biomedical Research Centre, University of Bristol, Bristol, UK. FAU - Hinton, Elanor C AU - Hinton EC AD - NIHR Bristol Biomedical Research Centre, University of Bristol, Bristol, UK. FAU - Robinson, Eric AU - Robinson E AD - Department of Psychology, University of Liverpool, Liverpool, UK. FAU - Jones, Andrew AU - Jones A AD - Department of Psychology, Liverpool John Moores University, Liverpool, UK. FAU - Bogosian, Angeliki AU - Bogosian A AD - Department of Psychology and Neuroscience, City St George's, University of London, London, UK. FAU - Chen, Ge AU - Chen G AD - NIHR Bristol Biomedical Research Centre, University of Bristol, Bristol, UK. FAU - Tapper, Katy AU - Tapper K AD - Department of Psychology and Neuroscience, City St George's, University of London, London, UK. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20260616 PL - United States TA - Clin Psychol Rev JT - Clinical psychology review JID - 8111117 SB - IM MH - Humans MH - *Mindfulness/methods MH - *Appetite/physiology MH - *Eating/psychology/physiology MH - *Feeding Behavior/psychology/physiology OTO - NOTNLM OT - Appetite OT - Eating behavior OT - Energy intake OT - Mindful eating OT - Mindfulness COIS- Declaration of competing interest No conflict of interest is identified by the authors. EDAT- 2026/06/24 18:34 MHDA- 2026/08/06 11:36 CRDT- 2026/06/24 18:01 PHST- 2026/02/06 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/08/06 11:36 [medline] PHST- 2026/06/24 18:34 [pubmed] PHST- 2026/06/24 18:01 [entrez] AID - S0272-7358(26)00089-9 [pii] AID - 10.1016/j.cpr.2026.102780 [doi] PST - ppublish SO - Clin Psychol Rev. 2026 Aug;128:102780. doi: 10.1016/j.cpr.2026.102780. Epub 2026 Jun 16. PMID- 42341183 OWN - NLM STAT- Publisher LR - 20260624 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) DP - 2026 Jun 24 TI - Ultra-Processed Foods and Health Outcomes in Children and Adults: An Updated Narrative Umbrella Review With a Focus on Dose-Response. LID - nuag099 [pii] LID - 10.1093/nutrit/nuag099 [doi] AB - Ultra-processed foods (UPFs) now contribute a substantial share of total energy intake. A growing body of evidence has linked UPF consumption to adverse health outcomes, but existing umbrella reviews are mainly restricted to studies published before mid-2023 and have seldom rigorously examined the shape of dose-response relationships, evaluating both linearity and nonlinearity. The aim of this study was to synthesize updated meta-analytic evidence on associations between UPF consumption and major health outcomes in children and adults. A narrative umbrella review synthesized meta-analyses of studies published through December 9, 2025. Outcomes included obesity, type 2 diabetes (T2D), cardio-cerebrovascular diseases (CCVDs), nonalcoholic fatty liver disease (NAFLD), cognition, mental health (anxiety and depression), dental health, cancer, and all-cause mortality. For each outcome, a lead meta-analysis was selected by comprehensiveness, recency, and methodological quality (separately for children and adults when feasible). Methodological quality was assessed using a ROBIS (Risk of Bias Assessment Tool for Systematic Reviews)-adapted tool. Certainty of evidence was rated with GRADE (Grading of Recommendations, Assessment, Development and Evaluation). Twelve lead meta-analyses (mainly from observational studies) covering 13 outcomes were identified (4/13 in children). Across all but 1 outcome, higher (vs lower) UPF consumption was associated with increased risk (see graphical abstract). Dose-response evidence indicated a 10% higher risk per 10% increase in UPF intake for T2D, a curvilinear risk increase for CCVDs, and no significant association for NAFLD; for other outcomes, rigorous dose-response analyses were lacking. Certainty of evidence was high for 1 outcome, moderate for 6, and low for 6 other outcomes. This updated umbrella review confirmed harmful associations of UPFs with multiple health outcomes, and added insights on children's health, cognition, dental health, CCVDs, and dose-response. Despite remaining methodological gaps (including observational-based and nonrigorous dose-response analyses), current evidence supports population-wide strategies to reduce UPF intake. Systematic Review Registration: PROSPERO registration no. CRD420251230427. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the International Life Sciences Institute. FAU - Descarpentrie, Alexandra AU - Descarpentrie A AUID- ORCID: 0000-0002-2666-5380 AD - Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, United States. FAU - Peare, Anna AU - Peare A AD - Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, United States. FAU - Goran, Michael I AU - Goran MI AD - Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, United States. LA - eng PT - Journal Article DEP - 20260624 PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM OTO - NOTNLM OT - health outcomes OT - ultra-processed foods OT - umbrella review EDAT- 2026/06/24 18:35 MHDA- 2026/06/24 18:35 CRDT- 2026/06/24 14:53 PHST- 2026/06/24 18:35 [medline] PHST- 2026/06/24 18:35 [pubmed] PHST- 2026/06/24 14:53 [entrez] AID - 8715784 [pii] AID - 10.1093/nutrit/nuag099 [doi] PST - aheadofprint SO - Nutr Rev. 2026 Jun 24:nuag099. doi: 10.1093/nutrit/nuag099. PMID- 42340620 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261003 IS - 1720-8386 (Electronic) IS - 0391-4097 (Print) IS - 0391-4097 (Linking) VI - 49 IP - 10 DP - 2026 Oct TI - Determinants of pubertal progression and final height in premature pubarche. PG - 2795-2802 LID - 10.1007/s40618-026-02957-6 [doi] AB - BACKGROUND: Premature pubarche (PP), defined as the early onset of pubic hair and often associated with mild androgen excess, is a common reason for referral to a pediatric endocrinologist. A small proportion of cases may progress to central precocious puberty (CPP). Data on the factors determining pubertal tempo and associated growth outcomes in these individuals are limited. OBJECTIVE: To identify predictors of pubertal progression and final height (FH) in girls with PP and to evaluate growth outcomes in those progressing to CPP. DESIGN-METHODS: We retrospectively analyzed 88 girls with PP who attained FH; 13 progressed to CPP (PP-to-CPP). Auxological data, bone age (BA), pubertal development, and plasma androgen profiles were evaluated. RESULTS: At presentation, corrected height SDS (CH-SDS) in girls with PP correlated with BA-SDS and BA/chronological age (BA/CA) ratio (p=0.03 and p=0.007). Corrected FH-SDS was positively associated with baseline CH-SDS in both PP and PP-to-CPP groups (p<0.001 and p=0.0002). Compared with PP, the PP-to-CPP group had higher baseline CH-SDS, BA-SDS and BA/CA ratio (all p=0.02). Baseline CH-SDS was the strongest independent predictor of corrected FH-SDS (p<0.001), while BMI-SDS showed a negative association (p=0.003). Baseline dehydroepiandrosterone-sulfate (DHEA-S) was not associated with CH-SDS, BA advancement, progression to CPP, or corrected FH-SDS in either group. Receiver operating characteristic (ROC) analyses for progression to CPP identified a BA/CA cutoff of 1.2; and a CH-SDS cutoff of 1.8 (p=0.01). CONCLUSION: Growth relative to genetic potential and skeletal maturation at presentation were the strongest predictors of progression to CPP and FH outcomes in girls with PP. Although DHEA-S reflects adrenal maturation and early androgen exposure, baseline DHEA-S concentrations were not associated with progression to CPP or long-term growth outcomes in our cohort. CI - (c) 2026. The Author(s). FAU - Helvacioglu, Didem AU - Helvacioglu D AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Canbaz, Aylin Tugba AU - Canbaz AT AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Eltan, Mehmet AU - Eltan M AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Cosar, Feride AU - Cosar F AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Turan, Serap AU - Turan S AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Bereket, Abdullah AU - Bereket A AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Guran, Tulay AU - Guran T AUID- ORCID: 0000-0003-2658-6866 AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. tulayguran@yahoo.com. LA - eng PT - Journal Article DEP - 20260624 PL - Italy TA - J Endocrinol Invest JT - Journal of endocrinological investigation JID - 7806594 SB - IM MH - Humans MH - Female MH - *Puberty, Precocious/physiopathology/blood/diagnosis MH - Retrospective Studies MH - Child MH - *Body Height/physiology MH - *Puberty/physiology MH - Follow-Up Studies MH - Disease Progression MH - Prognosis PMC - PMC13627192 OTO - NOTNLM OT - Bone age OT - DHEA-S OT - Final height OT - Precocious puberty OT - Premature adrenarche OT - Premature pubarche COIS- Declarations. Disclosure: The authors have nothing to disclose. EDAT- 2026/06/24 12:35 MHDA- 2026/09/30 17:32 PMCR- 2026/06/24 CRDT- 2026/06/24 11:20 PHST- 2026/04/25 00:00 [received] PHST- 2026/06/14 00:00 [accepted] PHST- 2026/09/30 17:32 [medline] PHST- 2026/06/24 12:35 [pubmed] PHST- 2026/06/24 11:20 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1007/s40618-026-02957-6 [pii] AID - 2957 [pii] AID - 10.1007/s40618-026-02957-6 [doi] PST - ppublish SO - J Endocrinol Invest. 2026 Oct;49(10):2795-2802. doi: 10.1007/s40618-026-02957-6. Epub 2026 Jun 24. PMID- 42340201 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260818 IS - 1728-0591 (Electronic) IS - 1728-0583 (Linking) VI - 37 IP - 2 DP - 2026 Aug TI - The associations between screen time and mental health in children aged 0-12: A systematic review. PG - 201-231 LID - 10.2989/17280583.2026.2661687 [doi] AB - BACKGROUND: : It is advised that children up to two years of age avoid any screen time (i.e., using digital screens), that those between the ages of two and five years should not exceed one hour per day, and that children aged five to 12 years should only have access to two hours of screen time per day. However, in the digital age, parents find it difficult to control the time their children spend on screens. AIM: : This article aimed to systematically synthesise the evidence on the associations between screen time and mental health outcomes in children aged 0 to 12 years. METHOD: : A systematic literature review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The search was defined according to the Population, Exposure, Comparator, and Outcomes (PECO) strategy, using the descriptors 'children', 'screen time' and 'mental health' when searching the databases PubMed, Scopus, and PsycINFO. Articles were included if they directly evaluated the associations between screen time and mental health, measured the results using validated instruments, included children aged 0 to 12 years, and were published since 2013. The Newcastle-Ottawa scale was used to check the methodological quality of the studies. The results were described by presenting the characteristics of the studies, the quality assessment, and the associations between screen time and mental health in longitudinal and cross-sectional studies. RESULTS: : This review assessed the quality of evidence and the frequency with which different mental health problems have been investigated in relation to screen time in children. Fifty-two studies were included, with most addressing attention deficit-hyperactivity disorder (n = 19), conduct problems (n = 13), externalising symptoms (n = 9), depression (n = 11), and anxiety (n = 9). Symptoms of attention deficit-hyperactivity disorder, oppositional defiant disorder, mood symptoms, emotional and social difficulties, conduct problems, low self-esteem, and sleep disturbances were positively associated with screen time, presenting evidence considered to be of high quality. LIMITATIONS: : Although this review concluded that screen time significantly affects children's mental health, some limitations should be noted. The lack of longitudinal data made it difficult to establish a clear causal relationship in most studies, and screen time measures may have introduced a potentia memory bias, as well as relying on parental recall. CONCLUSION: : Screen time warrants careful consideration in relation to children's mental health. Promoting off-screen activities may be crucial to reducing the risk of unfavourable mental health outcomes associated with exposure to the digital environment. Future research should focus on longitudinal studies to understand the causal relationships between children's psychosocial responses to the different purposes of screen use and the type of content to which they are exposed. FAU - Santos, Renata Maria Silva AU - Santos RMS AUID- ORCID: 0000-0001-5737-7712 AD - Federal University of Minas Gerais, Graduate Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Ventura, Samara de Alcantara AU - Ventura SA AUID- ORCID: 0000-0003-4167-8961 AD - Federal University of Minas Gerais, Scientific Research Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Goncalves, Maria Eduarda Oliveira de Albuquerque AU - Goncalves MEOA AUID- ORCID: 0009-0007-0839-9529 AD - Federal University of Minas Gerais, Scientific Research Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Nogueira, Yago Jean de Almeida AU - Nogueira YJA AUID- ORCID: 0000-0001-6215-4310 AD - Federal University of Minas Gerais, Scientific Research Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Mendes, Camila Guimaraes AU - Mendes CG AUID- ORCID: 0000-0001-8176-814X AD - Federal University of Minas Gerais, Graduate Program Children and Adolescent Health, Belo Horizonte, Minas Gerais, Brazil. FAU - Miranda, Debora Marques AU - Miranda DM AUID- ORCID: 0000-0002-7081-8401 AD - Federal University of Minas Gerais, Department of Pediatrics, Belo Horizonte, Minas Gerais, Brazil. FAU - Romano-Silva, Marco Aurelio AU - Romano-Silva MA AUID- ORCID: 0000-0002-6558-4639 AD - Federal University of Minas Gerais, Department of Psychiatry, Belo Horizonte, Minas Gerais, Brazil. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260624 PL - South Africa TA - J Child Adolesc Ment Health JT - Journal of child and adolescent mental health JID - 101242019 SB - IM MH - Child MH - Child, Preschool MH - Humans MH - Infant MH - Digital Media MH - Media Exposure MH - *Mental Health MH - *Screen Time MH - Male MH - Female MH - Infant, Newborn OTO - NOTNLM OT - children OT - media OT - mental health OT - screen time EDAT- 2026/06/24 12:36 MHDA- 2026/07/20 12:40 CRDT- 2026/06/24 09:53 PHST- 2026/07/20 12:40 [medline] PHST- 2026/06/24 12:36 [pubmed] PHST- 2026/06/24 09:53 [entrez] AID - 10.2989/17280583.2026.2661687 [doi] PST - ppublish SO - J Child Adolesc Ment Health. 2026 Aug;37(2):201-231. doi: 10.2989/17280583.2026.2661687. Epub 2026 Jun 24. PMID- 42340009 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260908 IS - 1365-2788 (Electronic) IS - 0964-2633 (Print) IS - 0964-2633 (Linking) VI - 70 IP - 10 DP - 2026 Oct TI - Validation of the Q87.11 ICD Code for Prader-Willi Syndrome. PG - 1125-1129 LID - 10.1111/jir.70140 [doi] AB - BACKGROUND: Prader-Willi syndrome (PWS) is a rare genetic disorder that is identified by the ICD-10 code Q87.11. Although this code has been used in several large studies, its diagnostic validity has not been evaluated. This study assessed the accuracy of the Q87.11 code for identifying individuals with PWS. METHODS: The electronic health record (EHR) of a large health system was reviewed for patients with the Q87.11 code. Additionally, a 10% random sample of patients with free-text evidence of possible PWS but no code was reviewed. All charts were assessed for PWS using expert review. Diagnostic validity of the Q87.11 code was assessed at both the individual level (i.e., using a single diagnostic code at any point in the EHR to define the patient as having PWS) and encounter level (looking at coding behaviour for individual inpatient or outpatient episodes of care) using sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). RESULTS: Of 2 718 218 patients with >/= 4 recorded encounters, 126 had at least one Q87.11 code; 122 were confirmed to have PWS by chart review. This yielded a PPV of 96.8% (95% CI: 92.0%-99.1%). Full-chart review of patients with text evidence of PWS but no code estimated a code sensitivity of 92.4% (95% CI: 68.9%-100%) and specificity and NPV of 100%. On a per-encounter basis, sensitivity was 79.4% (95% CI: 62.6%-91.1%) for inpatient and 46.0% (95% CI: 44.1%-47.9%) for outpatient visits. CONCLUSIONS: A single use of the Q87.11 diagnostic code produces excellent sensitivity, specificity, PPV and NPV for identifying patients with PWS, although sensitivity is lower for individual outpatient encounters compared with inpatient ones. The overall accuracy of the Q87.11 code supports the validity of using this code in the analysis of administrative claims datasets. CI - (c) 2026 MENCAP and John Wiley & Sons Ltd. FAU - Luccarelli, James AU - Luccarelli J AUID- ORCID: 0000-0002-1606-3917 AD - Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Strong, Theresa V AU - Strong TV AUID- ORCID: 0000-0001-6783-8703 AD - Foundation for Prader-Willi Research, Covina, California, USA. FAU - McCoy, Thomas H Jr AU - McCoy TH Jr AD - Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. LA - eng GR - T32 MH112485/MH/NIMH NIH HHS/United States GR - Foundation for Prader-Willi Research/ GR - T32MH112485/MH/NIMH NIH HHS/United States GR - T32MH112485/MH/NIMH NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20260624 PL - England TA - J Intellect Disabil Res JT - Journal of intellectual disability research : JIDR JID - 9206090 SB - IM MH - Humans MH - *Prader-Willi Syndrome/diagnosis MH - *International Classification of Diseases/standards MH - Female MH - Child MH - Child, Preschool MH - Adolescent MH - Male MH - Adult MH - *Electronic Health Records/statistics & numerical data/standards MH - Young Adult MH - Sensitivity and Specificity MH - Infant MH - Middle Aged PMC - PMC13374534 MID - NIHMS2192231 OTO - NOTNLM OT - Prader-Willi syndrome OT - coding OT - cohort studies OT - detection COIS- J.L. receives funding from Harvard Medical School Dupont Warren Fellowship and Livingston Awards, the Rappaport Foundation, the American Academy of Child and Adolescent Psychiatry and the Foundation for Prader-Willi Research. He has received equity and consulting fees from Revival Therapeutics Inc. and consulting fees from Soleno Therapeutics. T.V.S. is an employee of the Foundation for Prader-Willi Research and has received consulting fees from Soleno Therapeutics. T.H.M. receives funding, through his institution, from National Institute of Health, Telefonica Alfa, InterSystems, Philips Research North America and honoraria from Springer Nature publishing. EDAT- 2026/06/24 12:36 MHDA- 2026/09/08 23:35 PMCR- 2026/09/09 CRDT- 2026/06/24 09:39 PHST- 2026/06/15 00:00 [revised] PHST- 2025/08/20 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/09/08 23:35 [medline] PHST- 2026/06/24 12:36 [pubmed] PHST- 2026/06/24 09:39 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - JIR70140 [pii] AID - 10.1111/jir.70140 [doi] PST - ppublish SO - J Intellect Disabil Res. 2026 Oct;70(10):1125-1129. doi: 10.1111/jir.70140. Epub 2026 Jun 24. PMID- 42339977 OWN - NLM STAT- Publisher LR - 20260624 IS - 1532-530X (Electronic) IS - 1064-0266 (Linking) DP - 2026 Jun 24 TI - Maintenance of symptoms and weight-related gains following residential eating disorder treatment at discharge and one-year follow-up. PG - 1-23 LID - 10.1080/10640266.2026.2692537 [doi] AB - Eating disorders (EDs) are severe conditions with high relapse rates. Residential treatment may support recovery, yet long-term outcomes require further evaluation. This study examined changes in psychological symptoms and weight-related outcomes from intake to discharge and one-year follow-up in 275 female adolescents and adults admitted to a residential ED program. Participants completed measures of ED symptoms, anxiety, depression, and weight (BMI or %mBMI for adolescents) at each timepoint. Multilevel modeling, reliable change index (RCI), and clinically significant change (CSC) analyses evaluated symptom trajectories and treatment response. Adolescents and adults demonstrated large, clinically meaningful group-level improvements from intake to discharge across ED symptoms, anxiety, depression, and BMI. While small rebounds occurred between discharge and follow-up, net gains were substantial (p's < .001). Adults presented with more severe ED and anxiety symptoms than adolescents, but these differences were no longer significant by one-year follow-up. RCI/CSC analyses indicated that approximately 30-50% of the participants maintained clinically significant improvements at one-year follow-up on various outcomes. Most participants (70.9%) did not return to inpatient hospitalization or residential treatment within the year following discharge. Overall, residential treatment was associated with meaningful group-level symptoms and weight improvements that were generally sustained over a year, with substantial individual-level variation, providing additional data for its role in supporting ED recovery. FAU - Knudsen, Francesca M AU - Knudsen FM AUID- ORCID: 0009-0003-4241-8990 AD - Department of Psychology, Utah State University, Logan, UT, USA. FAU - Schwartz, Sarah E AU - Schwartz SE AUID- ORCID: 0000-0001-9980-7493 AD - Department of Psychology, Utah State University, Logan, UT, USA. FAU - Fitzpatrick, Madison AU - Fitzpatrick M AUID- ORCID: 0009-0008-9357-9918 AD - Department of Psychology, Utah State University, Logan, UT, USA. FAU - Chanenson, Samuel R AU - Chanenson SR AUID- ORCID: 0009-0003-8327-3097 AD - Department of Psychology, University of Richmond, Richmond, VA, USA. FAU - Lensegrav-Benson, Tera AU - Lensegrav-Benson T AD - Avalon Hills Eating Disorder Specialists, Logan, UT, USA. AD - Mindful Path Psychological Services, Logan, UT, USA. FAU - Quakenbush, Benita AU - Quakenbush B AD - Mindful Path Psychological Services, Logan, UT, USA. FAU - Twohig, Michael P AU - Twohig MP AUID- ORCID: 0000-0003-2936-5962 AD - Department of Psychology, Utah State University, Logan, UT, USA. LA - eng PT - Journal Article DEP - 20260624 PL - United States TA - Eat Disord JT - Eating disorders JID - 9315161 SB - IM EDAT- 2026/06/24 12:36 MHDA- 2026/06/24 12:36 CRDT- 2026/06/24 09:38 PHST- 2026/06/24 12:36 [medline] PHST- 2026/06/24 12:36 [pubmed] PHST- 2026/06/24 09:38 [entrez] AID - 10.1080/10640266.2026.2692537 [doi] PST - aheadofprint SO - Eat Disord. 2026 Jun 24:1-23. doi: 10.1080/10640266.2026.2692537. PMID- 42339945 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260813 IS - 2317-1782 (Electronic) IS - 2317-1782 (Linking) VI - 38 IP - 4 DP - 2026 TI - Habitual lip and tongue posture in infants with Trisomy 21: characterization and associated factors. PG - e20250157 LID - S2317-17822026000400608 [pii] LID - 10.1590/2317-1782/e20250157pt [doi] LID - e20250157 AB - PURPOSE: To characterize the habitual lip and tongue posture in infants with trisomy 21 and to verify its association with age, sex, and clinical characteristics. METHODS: This is an observational, cross-sectional, analytical study with a sample of 61 infants with trisomy 21, with a mean age of 7.4 +/- 6.2 months. The habitual lip and tongue posture was obtained through the analysis of videos of the infants' faces. Data regarding age, sex, and clinical conditions were collected from the participants' medical records. The study response variables were the habitual tongue and lip postures predominantly adopted by the infants. Explanatory variables included age, sex, prematurity, birth weight, heart disease, hypothyroidism, lung disease, breastfeeding, and use of bottles and pacifiers. Data were analyzed using descriptive statistics and Pearson's chi-square test for association between variables, with a 5% significance level. The study used 20% of the videos to verify the kappa coefficient and obtain intrarater and interrater agreement, classified as excellent and substantial, respectively. RESULTS: The longest postures were parted lips (48.2%) and tongue inside the oral cavity (32.4%). Lip posture was associated with age at the time of assessment and birth weight, and tongue posture was associated with breastfeeding. CONCLUSION: Younger chronological age at the time of assessment and higher birth weight were associated with better lip posture, while breastfeeding was associated with better tongue posture. FAU - Godinho, Leticia Pereira Quintaes AU - Godinho LPQ AUID- ORCID: 0009-0004-0959-3735 AD - Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil. FAU - Campos, Larissa Melgaco AU - Campos LM AUID- ORCID: 0009-0007-2571-376X AD - Programa de Pos-graduacao em Ciencias Fonoaudiologicas, Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil. FAU - Motta, Andrea Rodrigues AU - Motta AR AUID- ORCID: 0000-0002-1582-3785 AD - Programa de Pos-graduacao em Ciencias Fonoaudiologicas, Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil. AD - Departamento de Fonoaudiologia, Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil. FAU - Furlan, Renata Maria Moreira Moraes AU - Furlan RMMM AUID- ORCID: 0000-0001-7588-9316 AD - Programa de Pos-graduacao em Ciencias Fonoaudiologicas, Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil. AD - Departamento de Fonoaudiologia, Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil. LA - por LA - eng PT - Journal Article PT - Observational Study TT - Postura habitual dos labios e da lingua em lactentes com Trissomia do 21: caracterizacao e fatores associados. DEP - 20260619 PL - Brazil TA - Codas JT - CoDAS JID - 101623246 SB - IM MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - Age Factors MH - Birth Weight MH - Breast Feeding MH - Cross-Sectional Studies MH - *Down Syndrome/physiopathology MH - *Lip/physiology/physiopathology MH - Tongue/physiology MH - *Tongue Habits PMC - PMC13322487 COIS- Conflict of interests: nothing to declare. EDAT- 2026/06/24 12:35 MHDA- 2026/06/25 00:34 PMCR- 2026/06/19 CRDT- 2026/06/24 09:37 PHST- 2025/05/09 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/06/25 00:34 [medline] PHST- 2026/06/24 12:35 [pubmed] PHST- 2026/06/24 09:37 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - S2317-17822026000400608 [pii] AID - codas20250157_PT [pii] AID - 10.1590/2317-1782/e20250157pt [doi] PST - epublish SO - Codas. 2026 Jun 19;38(4):e20250157. doi: 10.1590/2317-1782/e20250157pt. eCollection 2026. PMID- 42339687 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260624 IS - 1471-2865 (Electronic) IS - 1358-2267 (Linking) VI - 31 IP - 3 DP - 2026 Jul TI - Aerobic Exercise Combined With Repetitive Transcranial Magnetic Stimulation in College Students at Suicide Risk: Protocol for a Single-Centre Non-Randomised Controlled Pilot Study. PG - e70263 LID - 10.1002/pri.70263 [doi] AB - BACKGROUND: College students are vulnerable to depressive symptoms, suicidal ideation, sleep disturbance, and stress-related psychological problems. Aerobic exercise and repetitive transcranial magnetic stimulation (rTMS) have each shown therapeutic potential in affective disorders, but evidence on their combined application in college students at suicide risk remains limited, particularly when neurophysiological outcomes are considered. OBJECTIVES: To evaluate the feasibility, safety, and preliminary effects of aerobic exercise combined with rTMS on suicidal ideation, depressive symptoms, sleep, and prefrontal functional activation in college students at suicide risk. METHODS: This prospective single-centre non-randomised controlled pilot study will enrol students aged 18-21 years who are identified as being at suicide risk by the Xinhai University Crisis Intervention System. At-risk participants will enter one of three groups: active rTMS plus aerobic exercise, sham rTMS plus aerobic exercise, or standardised group psychological intervention/usual support. A separately recruited healthy reference cohort will complete the same assessment schedule without active treatment. Active rTMS will be delivered over the left dorsolateral prefrontal cortex at 10 Hz and 120% of the individual motor threshold once daily for 2 weeks. Aerobic exercise will be prescribed at a target heart-rate zone of 135-164 beats/min for 30-60 min per session every 2 days for 2 weeks, with heart rate and adherence objectively monitored. OUTCOME MEASURES: The primary outcomes are changes in the Self-rating Idea of Suicide Scale (SIOSS) total score and Self-rating Depression Scale (SDS) standard score from baseline to week 4. Secondary outcomes include SIOSS and SDS dimensions, total sleep time, task-related and resting-state functional near-infrared spectroscopy (fNIRS) measures, adherence, concomitant care, and adverse events. ETHICS AND DISSEMINATION: The study was approved by the Ethical Review Committee of Yancheng First People's Hospital (Approval No. 2023-K-230) and the Ethics Committee of INTI International University (Approval No. INTI-IU/FHLS-RC/BTCMI/AUGUST2022/003). Findings will be disseminated through peer-reviewed publications and academic conferences. TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2400079723. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Yu, Cui AU - Yu C AUID- ORCID: 0009-0005-7604-3992 AD - Jiangsu Medical College, Yancheng, China. FAU - Lu, Yuwen AU - Lu Y AD - Jiangsu Vocational Institute of Commerce, Nanjing, China. FAU - Peng, Cheng AU - Peng C AD - Jiangsu Medical College, Yancheng, China. FAU - Wang, Ziyi AU - Wang Z AD - Jiangsu Medical College, Yancheng, China. FAU - Wong, Ling Shing AU - Wong LS AUID- ORCID: 0000-0002-5869-0804 AD - INTI International University, Nilai, Malaysia. FAU - Dong, Xinchun AU - Dong X AUID- ORCID: 0009-0002-9717-6151 AD - Jiangsu Medical College, Yancheng, China. LA - eng GR - 2022B02/Jiangsu Primary Health Development and General Medicine Education Research Center/ GR - JSS-L-2024024/2024 Jiangsu Provincial Social Education Planning Project/ GR - C/2024/01/98/2024 Jiangsu Provincial Education Science Planning Project Youth Special/ GR - Z202512/The Major Research Project of the Wuxi Municipal Health Commission/ GR - Q202419/Youth Project of the Wuxi Municipal Health Commission/ PT - Journal Article PL - United States TA - Physiother Res Int JT - Physiotherapy research international : the journal for researchers and clinicians in physical therapy JID - 9612022 SB - IM MH - Humans MH - Pilot Projects MH - Young Adult MH - *Transcranial Magnetic Stimulation/methods MH - Female MH - Adolescent MH - Prospective Studies MH - Male MH - *Exercise/psychology MH - *Students/psychology MH - *Suicide Prevention MH - Depression/therapy MH - Suicidal Ideation MH - Feasibility Studies MH - Universities OTO - NOTNLM OT - aerobic exercise OT - college students OT - depression OT - feasibility studies OT - functional near-infrared spectroscopy OT - repetitive transcranial magnetic stimulation OT - sleep OT - suicidal ideation OT - suicide risk EDAT- 2026/06/24 12:35 MHDA- 2026/06/25 00:34 CRDT- 2026/06/24 06:33 PHST- 2026/05/26 00:00 [revised] PHST- 2026/04/19 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/06/25 00:34 [medline] PHST- 2026/06/24 12:35 [pubmed] PHST- 2026/06/24 06:33 [entrez] AID - 10.1002/pri.70263 [doi] PST - ppublish SO - Physiother Res Int. 2026 Jul;31(3):e70263. doi: 10.1002/pri.70263. PMID- 42339555 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260911 IS - 1365-2788 (Electronic) IS - 0964-2633 (Print) IS - 0964-2633 (Linking) VI - 70 IP - 10 DP - 2026 Oct TI - Assessing the Diagnostic Performance of Triglyceride-Glucose-Based Indices for Early Detection of Metabolic Syndrome in Paediatric Down Syndrome. PG - 1022-1032 LID - 10.1111/jir.70134 [doi] AB - BACKGROUND: Down syndrome (DS) youth have an increased risk of metabolic syndrome (MetS). This study assessed the diagnostic performance of the triglyceride-glucose index (TyG) and its derivatives-TyG-BMI, TyG-waist circumference (WC) and TyG-waist-to-height ratio (WHtR) in detecting MetS compared with traditional markers. METHODS: We retrospectively analysed data from 60 DS patients and 40 controls; IR was estimated using HOMA-IR, TyG, TyG-BMI, TyG-WC and TyG-WHtR indices. MetS was defined by the presence of at least three of the following criteria: BMI z-score >/= 2 SD and/or WC/H ratio >/= 0.5; fasting glucose > 100 mg/dL and/or pathological HOMA-IR; dyslipidaemia; hypertension. RESULTS: MetS prevalence was 15% in DS. HOMA-IR showed the highest sensitivity (0.667) and specificity (0.80) to detect MetS, while TyG demonstrated similar performance (sensitivity 0.667; specificity 0.843) and the best overall accuracy (0.817). Composite indices showed moderate accuracy but high specificity. CONCLUSIONS: TyG, being simple and cost-effective, may be a valuable alternative for early MetS detection in DS. CI - (c) 2026 The Author(s). Journal of Intellectual Disability Research published by MENCAP and John Wiley & Sons Ltd. FAU - Calcaterra, Valeria AU - Calcaterra V AUID- ORCID: 0000-0002-2137-5974 AD - Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy. AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Labati, Lucia AU - Labati L AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, Milan, Italy. FAU - Gazzarri, Alessandra Anna AU - Gazzarri AA AD - Associazione Vivi Down Onlus, Milan, Italy. FAU - De Lorenzo, Alice AU - De Lorenzo A AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Scavone, Ilaria Anna Maria AU - Scavone IAM AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, Milan, Italy. LA - eng PT - Journal Article DEP - 20260624 PL - England TA - J Intellect Disabil Res JT - Journal of intellectual disability research : JIDR JID - 9206090 RN - 0 (Triglycerides) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Metabolic Syndrome/diagnosis/epidemiology/blood MH - *Triglycerides/blood MH - Female MH - Retrospective Studies MH - Child MH - Early Diagnosis MH - *Down Syndrome/epidemiology/blood MH - Male MH - *Blood Glucose/metabolism MH - Adolescent MH - Sensitivity and Specificity MH - Child, Preschool PMC - PMC13553318 OTO - NOTNLM OT - Down syndrome OT - HOMA-IR OT - children OT - metabolic syndrome OT - paediatrics OT - triglyceride-glucose-based indices COIS- The authors declare no conflicts of interest. EDAT- 2026/06/24 06:39 MHDA- 2026/09/08 23:35 PMCR- 2026/09/09 CRDT- 2026/06/24 05:03 PHST- 2026/05/29 00:00 [revised] PHST- 2025/10/24 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/09/08 23:35 [medline] PHST- 2026/06/24 06:39 [pubmed] PHST- 2026/06/24 05:03 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - JIR70134 [pii] AID - 10.1111/jir.70134 [doi] PST - ppublish SO - J Intellect Disabil Res. 2026 Oct;70(10):1022-1032. doi: 10.1111/jir.70134. Epub 2026 Jun 24. PMID- 42339358 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260624 LR - 20260913 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Health-related perceptions and drinking motives as actionable targets for precision prevention of high sugar-sweetened beverage intake among Chinese adolescents. PG - 1803900 LID - 10.3389/fnut.2026.1803900 [doi] LID - 1803900 AB - OBJECTIVE: To quantify the contribution of modifiable individual risk factors (MIRFs)-particularly health-related perceptions and drinking motives-to high sugar-sweetened beverage (SSB) intake among adolescents, and to evaluate their relevance as actionable targets for precision-oriented prevention. METHODS: A school-based survey was conducted among 1,466 Chinese junior high school students to assess SSB consumption and related individual-level factors. Multivariable logistic regression was used to identify factors associated with high SSB intake. To illustrate the practical value of these modifiable factors for identifying and targeting high-risk individuals, a population-based risk stratification approach was applied and evaluated using internal and external datasets. Model performance was assessed using the area under the receiver operating characteristic curve (AUC-ROC), calibration curves, and decision curve analysis (DCA). RESULTS: Four MIRFs-drinking SSBs as water (OR = 13.00, 95% CI: 7.33-23.07, R (2) = 11.12%), belief in no health effects ["Yes": OR = 10.61(4.82-23.34); "Unsure": OR = 2.37 (1.21-4.62); R (2) = 4.99%], a strong desire to consume SSBs (OR = 2.45, 1.49-4.02, R (2) = 1.91%), and drinking due to boredom (OR = 2.27, 1.25-4.13, R (2) = 1.00%)-were strongly associated with high SSB intake (p < 0.05), collectively accounting for 71.1% of the model-explained variance. The full model demonstrated good discrimination, with AUCs of 0.858 in the training set, 0.736 in the internal validation set, and 0.751 in the external validation set, along with satisfactory calibration. A simplified model including only these MIRFs showed comparable net benefit in DCA, supporting their potential utility for efficient screening and risk stratification. CONCLUSION: Health-related perceptions and non-physiological drinking motives are key modifiable correlates of high SSB intake among adolescents. An MIRF-based screening and targeting approach may support precision prevention strategies and more efficient allocation of intervention resources in school- and community-based public health programs. CI - Copyright (c) 2026 Peng, Yi, Yan, Chen, Zhou, Bai, Sheng, Fang, Wang, Lin and Wu. FAU - Peng, Yuting AU - Peng Y AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. AD - Department of Health Management, Changzhou Health Vocational Technology College, Changzhou, China. FAU - Yi, Junyao AU - Yi J AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Yan, Xiaoyun AU - Yan X AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Chen, Xinyi AU - Chen X AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Zhou, Yu AU - Zhou Y AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Bai, Zijun AU - Bai Z AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Sheng, Zuyun AU - Sheng Z AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Fang, Dawei AU - Fang D AD - Jiangsu Defuxiyun Health Technology Co., Ltd, Nanjing, China. FAU - Wang, Danyang AU - Wang D AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Lin, Xiaofang AU - Lin X AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Wu, Jieshu AU - Wu J AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260608 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13283865 OTO - NOTNLM OT - adolescent OT - drinking motives OT - health-related perceptions OT - modifiable individual risk factors OT - nutritional epidemiology OT - precision prevention OT - sugar-sweetened beverage COIS- DF was employed by Jiangsu Defuxiyun Health Technology Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/24 06:39 PMCR- 2026/06/08 CRDT- 2026/06/24 04:46 PHST- 2026/02/04 00:00 [received] PHST- 2026/04/07 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/24 06:39 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 04:46 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.3389/fnut.2026.1803900 [doi] PST - epublish SO - Front Nutr. 2026 Jun 8;13:1803900. doi: 10.3389/fnut.2026.1803900. eCollection 2026. PMID- 42339296 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260922 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Comparison of Chinese and international birth weight standards in predicting early childhood growth outcomes: a retrospective cohort study. PG - 1810686 LID - 10.3389/fped.2026.1810686 [doi] LID - 1810686 AB - BACKGROUND: Birth weight serves as a key predictor for long-term health trajectories. Currently, both international and Chinese standards are used to evaluate birth weight. This study aims to compare the Chinese Newborn Growth Standards (CNGS) and the INTERGROWTH-21st (IG-21) standards in terms of birth weight classification and their predictive performance for the wasting and possible risk of overweight during infancy and toddlerhood. METHODS: This retrospective cohort study included 1,149 full-term singleton infants with longitudinal growth data recorded at 1, 2, and 3 years of age. Birth weight was categorized according to both the CNGS and IG-21 standards. Wasting and possible risk of overweight during infancy and toddlerhood were assessed according to World Health Organization (WHO) standards. Agreement between the two classification systems was evaluated using the weighted Kappa statistic. The predictive performance of each standard for growth outcomes was compared using modified Poisson regression models. RESULTS: The CNGS and IG-21 standards showed high agreement (Kappa = 0.856). In terms of predictive performance, based on the CNGS, small for gestational age (SGA) was significantly associated with wasting at 1 and 2 years, and large for gestational age (LGA) was significantly associated with possible risk of overweight at 2 years. In contrast, based on the IG-21 standards, only SGA showed a significant association with wasting across all follow-up ages. Overall, the CNGS demonstrated higher specificity in predicting wasting and possible risk of overweight in infants and toddlers. CONCLUSION: Although the CNGS and IG-21 standards showed high agreement, the CNGS demonstrated superior predictive validity for growth outcomes during infancy and toddlerhood, particularly for possible risk of overweight. CI - (c) 2026 Zhang, Zhang, Gao, Li, Zhang, Liu and Li. FAU - Zhang, Ting AU - Zhang T AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Zhang, Zhenyu AU - Zhang Z AD - School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China. FAU - Gao, Mai AU - Gao M AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Li, Ziyun AU - Li Z AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Zhang, Li AU - Zhang L AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Liu, Huijuan AU - Liu H AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Li, Yan AU - Li Y AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. LA - eng PT - Journal Article DEP - 20260608 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 EIN - Front Pediatr. 2026 Jul 20;14:1905752. doi: 10.3389/fped.2026.1905752. PMID: 42549124 PMC - PMC13284055 OTO - NOTNLM OT - birth weight OT - growth standards OT - possible risk of overweight OT - predictive validity OT - wasting COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/24 06:36 MHDA- 2026/06/24 06:37 PMCR- 2026/06/08 CRDT- 2026/06/24 04:45 PHST- 2026/02/13 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/24 06:36 [pubmed] PHST- 2026/06/24 06:37 [medline] PHST- 2026/06/24 04:45 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1810686 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 8;14:1810686. doi: 10.3389/fped.2026.1810686. eCollection 2026. PMID- 42339295 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260624 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - A novel nutritional tool to identify infants at risk of stunting. PG - 1782208 LID - 10.3389/fped.2026.1782208 [doi] LID - 1782208 AB - OBJECTIVE: This study aimed to develop and validate a novel scoring system and prediction algorithm integrating growth, nutritional, and biochemical indicators for the identification of infant stunting, defined as length-for-age Z-score < -2 standard deviations according to the World Health Organization (WHO) Child Growth Standards. METHODS: A retrospective cohort of 380 infants (aged 0-12 months) undergoing routine health examinations was enrolled. Participants were randomly allocated to a training set (n = 266) and a internal validation set (n = 114) in a 7:3 ratio. In the training set, univariate analysis identified candidate indicators (P < 0.05). Multivariate logistic regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression were subsequently used to select independent predictors and prevent overfitting. Three machine learning models-Random Forest, Gradient Boosting, and Support Vector Machine-were constructed. Model performance was evaluated using the Area Under the Receiver Operating Characteristic Curve (AUC), calibration curves, and Decision Curve Analysis. Interpretability was assessed via SHapley Additive exPlanations (SHAP) values. A visual nomogram was developed. RESULTS: Baseline characteristics were comparable between the training and internal validation sets (P > 0.05). Five indicators were significantly associated with stunting, including infant weight Z-score, length Z-score, length growth velocity, diversity of complementary foods, and hemoglobin (Hb). Length growth velocity was the strongest predictor (OR=0.340, 95% CI: 0.211-0.548, P < 0.001). LASSO regression confirmed infant weight Z-score, length Z-score, length growth velocity, number of complementary food types, and Hb as the optimal variable combination. The Gradient Boosting model demonstrated superior performance, with an AUC of 0.861 (95% CI: 0.784-0.938) in the training set and 0.850 (95% CI: 0.699-1.000) in the internal validation set. Its calibration was excellent, and decision curve analysis indicated a higher net benefit across a wide risk threshold range. SHAP analysis identified infant weight Z-score as the most critical predictive variable. The nomogram provided a practical tool for quantitative risk assessment. CONCLUSION: The developed nutritional scoring system and Gradient Boosting prediction algorithm exhibited robust performance in identifying infants at risk of stunting. This tool facilitates early quantitative risk assessment and supports targeted clinical interventions. CI - (c) 2026 Wei, Su, Wei and Zhan. FAU - Wei, Qian AU - Wei Q AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. FAU - Su, Dandan AU - Su D AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. FAU - Wei, Jihong AU - Wei J AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. FAU - Zhan, Yaowu AU - Zhan Y AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. LA - eng PT - Journal Article DEP - 20260608 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13283820 OTO - NOTNLM OT - SHAP values OT - infant growth faltering OT - machine learning OT - nutritional scoring system OT - prediction algorithm COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/24 06:39 PMCR- 2026/06/08 CRDT- 2026/06/24 04:45 PHST- 2026/01/06 00:00 [received] PHST- 2026/05/21 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/24 06:39 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 04:45 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1782208 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 8;14:1782208. doi: 10.3389/fped.2026.1782208. eCollection 2026. PMID- 42339293 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260624 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Baseline gut microbiome features associated with fecal calprotectin response to exclusive enteral nutrition in pediatric Crohn's disease. PG - 1833193 LID - 10.3389/fped.2026.1833193 [doi] LID - 1833193 AB - BACKGROUND AND AIMS: Exclusive enteral nutrition is an established induction therapy for pediatric Crohn's disease, but biochemical response varies across patients. We assessed whether baseline gut microbiome features were associated with fecal calprotectin response and whether treatment-related taxonomic shifts could be interpreted alongside reported fecal biochemical summaries. METHODS: We re-analyzed a public pediatric cohort (PRJEB14084). Paired baseline and end-of-treatment microbiome profiles were summarized as within-subject genus-level changes. Reported stool biochemical summaries were used as contextual data. Baseline model performance was explored by repeated nested cross-validation with calibration assessment. An independent pediatric cohort (PRJEB33603) was used only for summary-level external comparison. RESULTS: Several genera changed consistently during treatment. Stool biochemical summaries showed lower total amino acids and tryptophan and higher secondary bile-acid proportion and hydrophobicity index at the end of treatment. The baseline model showed modest discrimination with broad uncertainty (mean area under the receiver operating characteristic curve, 0.655; 95% confidence interval, 0.450-0.850). In the external comparison, 7 of 12 overlapping genera showed concordant directions. CONCLUSION: In this public cohort, baseline microbiome features showed an exploratory association with fecal calprotectin response, but the estimates were imprecise. External comparison was limited to published summary tables, and all inferences remain association-based. CI - (c) 2026 Zheng and Chen. FAU - Zheng, Hongwei AU - Zheng H AD - School of Medicine, Quanzhou Medical College, Quanzhou, Fujian, China. FAU - Chen, Wenbiao AU - Chen W AD - School of Medicine, Quanzhou Medical College, Quanzhou, Fujian, China. LA - eng PT - Journal Article DEP - 20260608 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13284047 OTO - NOTNLM OT - 16S rRNA gene sequencing OT - exclusive enteral nutrition OT - fecal calprotectin OT - gut microbiome OT - pediatric Crohn's disease COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/24 06:39 PMCR- 2026/06/08 CRDT- 2026/06/24 04:45 PHST- 2026/03/18 00:00 [received] PHST- 2026/04/26 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/24 06:39 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 04:45 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1833193 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 8;14:1833193. doi: 10.3389/fped.2026.1833193. eCollection 2026. PMID- 42338068 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2398-9238 (Electronic) IS - 2398-9238 (Linking) VI - 9 IP - 4 DP - 2026 Jul TI - Dietary Phytochemical Index and Its Relationship With Diminished Ovarian Reserve: Evidence From a Case-Control Study. PG - e70201 LID - 10.1002/edm2.70201 [doi] LID - e70201 AB - INTRODUCTION: Diminished ovarian reserve (DOR) represents a significant contributor to female infertility and adverse reproductive outcomes. Although diet may play a role, the specific impact of phytochemical-rich dietary patterns remains underexplored. So, we aimed to investigate the association between adherence to a dietary phytochemical index (DPI) and the likelihood of DOR among women attending fertility clinics. METHODS: This case-control study enrolled 370 women, comprising 120 individuals diagnosed with DOR and 250 age- and body mass index (BMI)-matched controls with normal ovarian reserve. A validated semi-quantitative food frequency questionnaire (FFQ) was applied to assess dietary intakes and, accordingly, DPI was calculated as the proportion of total energy intake obtained from phytochemical-abundant foods. Antral follicle count (AFC) and serum anti-Mullerian hormone (AMH) measurements were utilized as indicators of ovarian reserve. The association between DPI and the odds of DOR was investigated using multivariable logistic regression models. RESULTS: Our findings showed that higher DPI was associated with a reduced odds of DOR (Q4 vs. Q1 OR: 0.79; 95% CI: 0.55-0.93; p-trend = 0.010). After adjustment for physical activity and energy intake, the association remained significant (OR: 0.80; 95% CI: 0.54-0.95; p-trend = 0.033). In the fully adjusted model, which included additional adjustments for fat mass and body mass index, women in the highest DPI quartile had 27% lower odds of DOR compared to those in the lowest quartile (OR: 0.73; 95% CI: 0.42-0.97; p-trend = 0.02). Besides, in the control group, AFC differed significantly across DPI quartiles (p < 0.001), with the highest mean in the second quartile. CONCLUSION: Our findings suggest that a phytochemical-rich diet may help reduce the odds of DOR, highlighting the role of diet in reproductive health. However, further prospective studies and mechanistic research are warranted to confirm these results and clarify underlying pathways. CI - (c) 2026 The Author(s). Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. FAU - Khodarahmi, Mahdieh AU - Khodarahmi M AUID- ORCID: 0000-0002-0689-6958 AD - Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Askari, Gholamreza AU - Askari G AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Vajdi, Mahdi AU - Vajdi M AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Mokari-Yamchi, Amin AU - Mokari-Yamchi A AD - Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran. FAU - Ghasemi-Tehrani, Hatav AU - Ghasemi-Tehrani H AD - Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Kalatehjari, Maryam AU - Kalatehjari M AD - Obstetrics & Gynecology Department, University of Washington, Seattle, USA. FAU - Ghavami, Abed AU - Ghavami A AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng GR - 2401257/Isfahan University of Medical Sciences/ PT - Journal Article PT - Observational Study PL - England TA - Endocrinol Diabetes Metab JT - Endocrinology, diabetes & metabolism JID - 101732442 RN - 0 (Phytochemicals) RN - 80497-65-0 (Anti-Mullerian Hormone) SB - IM MH - Case-Control Studies MH - *Diet/adverse effects/statistics & numerical data MH - *Phytochemicals/administration & dosage MH - *Ovarian Reserve/drug effects/physiology MH - *Eating/physiology MH - Humans MH - Female MH - Adult MH - Body Mass Index MH - Infertility, Female/epidemiology/etiology MH - Diet Surveys MH - Anti-Mullerian Hormone/blood MH - Ovarian Follicle/drug effects MH - Adolescent MH - Young Adult MH - Middle Aged PMC - PMC13291195 OTO - NOTNLM OT - dietary phytochemical index OT - diminished ovarian reserve OT - infertility OT - ovarian function OT - phytochemicals COIS- The authors declare no conflicts interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/25 00:33 PMCR- 2026/06/23 CRDT- 2026/06/24 02:23 PHST- 2026/02/08 00:00 [revised] PHST- 2025/11/04 00:00 [received] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 02:23 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - EDM270201 [pii] AID - 10.1002/edm2.70201 [doi] PST - ppublish SO - Endocrinol Diabetes Metab. 2026 Jul;9(4):e70201. doi: 10.1002/edm2.70201. PMID- 42337997 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20261020 IS - 1556-8342 (Electronic) IS - 1556-8253 (Linking) VI - 21 IP - 9 DP - 2026 Sep TI - The Effects of Postpartum Foot Massage on Maternal Breastfeeding Success, Sleep Quality, and Newborn Stress: A Randomized Controlled Trial. PG - 513-524 LID - 10.1177/15568253261457845 [doi] AB - OBJECTIVE: This study was conducted to evaluate the effects of foot massage applied to the mother in the early postpartum period on breastfeeding success, sleep quality, and newborn stress levels. METHOD: The study was conducted using a parallel-group randomized controlled trial design. The study included 70 primiparous postpartum women who had vaginal deliveries at a public hospital in southern Turkiye between December 2024 and August 2025. Participants were randomized into intervention (n = 35) and control (n = 35) groups. The intervention group received a total of 12 sessions (30 minutes each) of foot massage, three times a week for four weeks, starting from the first week postpartum, in addition to standard postpartum care. The control group received only standard postpartum care. Data were collected using the Personal Information Form, LATCH Breastfeeding Charting System and Documentation Tool, Pittsburgh Sleep Quality Index (PSQI), and the Newborn Stress Scale (NSS). The Mann-Whitney U test, Wilcoxon signed-rank test, and Friedman test were used for data analysis; statistical significance was set at p < 0.05. RESULTS: Initially, the groups were similar in sociodemographic and clinical characteristics (p > 0.05). Lactation success (LATCH) scores increased significantly in the intervention group in weekly measurements, and statistically significant differences were found at the 1st, 2nd, and 3rd follow-ups compared with the control group (p < 0.001). Sleep quality (PSQI) scores decreased significantly in the intervention group in the pre-test-post-test comparison (improvement in sleep quality) (p < 0.001). At the same time, no significant change was observed in the control group (p = 0.087). NSS scores decreased more markedly in the intervention group, with significant between-group differences observed at the 2nd and 3rd follow-ups (p < 0.001). CONCLUSION: Foot massage applied to the mother in the postpartum period increases breastfeeding success, improves maternal sleep quality, and reduces newborn stress levels. Foot massage can be considered an effective, safe, and feasible nonpharmacological intervention in postpartum care practices. FAU - Keceli, Melek Nur AU - Keceli MN AD - Kahramanmaras Necip Fazil Sehir Hastanesi, Kahramanmaras, Turkey. FAU - Oztas, Hatice Gul AU - Oztas HG AUID- ORCID: 0000-0003-3574-2509 AD - Department of Midwifery, Faculty of Health Sciences, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. LA - eng SI - ClinicalTrials.gov/NCT06786481 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260623 PL - United States TA - Breastfeed Med JT - Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine JID - 101260777 SB - IM MH - Humans MH - Female MH - *Massage/methods MH - *Breast Feeding/psychology MH - Infant, Newborn MH - Adult MH - *Postpartum Period/psychology MH - *Stress, Psychological/prevention & control MH - Sleep Quality MH - *Mothers/psychology MH - *Foot MH - Pregnancy MH - *Postnatal Care/methods MH - Lactation OTO - NOTNLM OT - breastfeeding success OT - foot massage OT - midwifery OT - newborn stress OT - postpartum care OT - sleep quality COIS- Disclosure StatementNo competing financial interests exist. EDAT- 2026/06/24 06:39 MHDA- 2026/08/02 00:30 CRDT- 2026/06/24 02:04 PHST- 2026/08/02 00:30 [medline] PHST- 2026/06/24 06:39 [pubmed] PHST- 2026/06/24 02:04 [entrez] AID - 10.1177/15568253261457845 [doi] PST - ppublish SO - Breastfeed Med. 2026 Sep;21(9):513-524. doi: 10.1177/15568253261457845. Epub 2026 Jun 23. PMID- 42337511 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 24 TI - Nonlinear association between body mass index and physical fitness in primary school children: a single-school cross-sectional study using generalized additive models. LID - 10.1186/s12887-026-07226-2 [doi] LID - 843 AB - BACKGROUND: Body mass index (BMI) is associated with physical fitness in children, but the functional form of this relationship is debated. Using routinely collected fitness-monitoring data from a single primary school, this study examined whether BMI is nonlinearly associated with physical fitness in primary school children, treating the analysis as a methodological, single-school demonstration rather than a population-representative survey. METHODS: We analysed records from 1,572 students (808 boys, 764 girls; Grades 1-6) nested within 37 classes in one school in Tianfu New Area, Sichuan, China. BMI was calculated from measured height and weight. Four fitness indicators available for the whole sample-vital capacity, 50-m sprint, sit-and-reach, and 1-min rope skipping-were analysed as the primary outcomes; a composite index (mean of sex- and grade-standardised z-scores, with the 50-m sprint reverse-coded so that higher scores denote better fitness) was retained as a secondary descriptive summary. Quadratic regression and generalized additive models (GAMs; penalised cubic B-splines) adjusted for sex and grade were used to model BMI. Primary overall and sex-stratified models used cluster-robust standard errors at the class level; grade-stratified exploratory models, each based on only a few classes, were assessed with model-based smooth tests. Nonlinearity was quantified with the effective degrees of freedom (EDF) of the BMI smooth and a Wald test, and exploratory subgroup analyses were corrected for multiple comparisons (Benjamini-Hochberg false discovery rate, FDR). RESULTS: The class-level intraclass correlation was non-negligible for BMI (0.124) and the 50-m sprint (0.085), confirming the need to account for clustering. After cluster-robust adjustment, BMI showed a statistically supported nonlinear association with the 50-m sprint (EDF = 4.4, P < 0.001), 1-min rope skipping (EDF = 5.1, P < 0.001), and the composite index (EDF = 5.7, P < 0.001), but not with vital capacity (EDF = 1.0, P = 0.44). For the 50-m sprint the best predicted performance was well localised at a BMI of about 16.2 kg/m(2); for 1-min rope skipping the optimum was less precisely located, and for the composite index the cluster bootstrap did not identify a stable interior optimum (it spread the maximum across approximately 15.7-21.2 kg/m(2), with a median of approximately 19.7 kg/m(2) well above the full-sample point estimate). Predicted performance declined at both lower and higher BMI. The quadratic turning point (~ 18.5 kg/m(2)) was higher than the GAM peak and moved toward the GAM estimate when sparse BMI tails were trimmed, indicating sensitivity of the parabola to extreme values. In exploratory, FDR-corrected subgroup analyses, nonlinearity remained statistically supported in girls and in Grades 1 and 3 but not in boys or other grades; these subgroup findings are hypothesis-generating only. CONCLUSIONS: In this single-school sample, the BMI-fitness association was nonlinear for speed- and coordination-related tasks; for the 50-m sprint the best predicted performance was well localised at an intermediate BMI (about 16.2 kg/m(2)), whereas for the composite index no stable single optimum could be identified. Because the data come from one school and lack body-composition and physical-activity measures, the estimated optima are sample-specific descriptive features and should not be read as intervention targets. The study illustrates how routine school fitness data and GAMs can describe BMI-fitness patterns beyond categorical comparisons, and motivates multi-school, longitudinal confirmation. CI - (c) 2026. The Author(s). FAU - Zhu, Junhui AU - Zhu J AD - Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Malaysia. FAU - Zhao, Mingling AU - Zhao M AD - School of Urban Construction, Chengdu Polytechnic, Chengdu, China. FAU - Zheng, Meiling AU - Zheng M AD - Tianfu School of Tsinghua University High School, Meishan, China. FAU - Wang, Ling AU - Wang L AD - Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Malaysia. FAU - Li, Qiuyue AU - Li Q AD - School of Physical Education and Big Health, Sichuan Technology and Business University, Chengdu, China. 1039571063@qq.com. LA - eng PT - Journal Article DEP - 20260624 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Body Mass Index MH - *Physical Fitness/physiology MH - Male MH - Child MH - Cross-Sectional Studies MH - Female MH - China MH - Schools MH - Nonlinear Dynamics PMC - PMC13555981 OTO - NOTNLM OT - Body mass index OT - Children OT - Cluster-robust inference OT - Generalized additive models OT - Nonlinear association OT - Physical fitness OT - School health COIS- Declarations. Ethics approval and consent to participate: This study involving human participants was reviewed and approved by the Ethics Committee of Yibin University (Approval No. YBULLXS26041601). All procedures were performed in accordance with the Declaration of Helsinki and relevant guidelines and regulations. Written informed consent was obtained from the participants' legal guardians, and assent was obtained from the children where appropriate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/24 06:37 MHDA- 2026/09/09 11:38 PMCR- 2026/06/24 CRDT- 2026/06/24 00:07 PHST- 2026/04/22 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/06/24 06:37 [pubmed] PHST- 2026/06/24 00:07 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1186/s12887-026-07226-2 [pii] AID - 7226 [pii] AID - 10.1186/s12887-026-07226-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 24;26(1):843. doi: 10.1186/s12887-026-07226-2. PMID- 42337484 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Single-model deep learning approach for simultaneous cervical vertebral maturation staging and skeletal jaw relationship on lateral cephalograms using YOLOv8 and CNN. LID - 10.1186/s12903-026-08578-y [doi] LID - 1107 AB - BACKGROUND: This study aimed to develop an integrated artificial intelligence (AI) pipeline for cervical vertebral maturation (CVM) staging and skeletal jaw relationships and to validate its output against the results of human observers. METHODS: A total of 720 lateral cephalograms were collected from the archives of the orthodontic department. The participants' ages ranged from 8 to 18 years. Cephalograms were categorized into six cervical stages based on McNamara's criteria and classified into skeletal Class I, II, and III patterns based on their ANB angles. The dataset was divided into a training set (n = 540) and a test set (n = 180). The training set was used to train a convolutional neural network (CNN) and a YOLOv8 model. The test set of cephalograms was coded and randomly assigned to two orthodontists for comparison with the AI model results using weighted kappa and Cohen's kappa statistical analyses to verify accuracy. RESULTS: For human observers, the interobserver agreement ranges were as follows: (kappaw approximately 0.976-0.989) for skeletal classification and (kappaw approximately 0.956-0.999) for CVM staging, while the intra-observer reliability was also almost perfect for both methods (kappaw approximately 0.82- 0.85). Substantial agreement was found between the generated AI model and human observers for skeletal classification (kappa = 0.725) and CVM staging (kappa = 0.786). Both results were statistically significant (p < 0.01). CONCLUSIONS: Within the limitations of this study, the AI model exhibited substantial agreement with human observers for CVM staging and skeletal assessment, demonstrating its potential viability as a clinical decision-support tool. CI - (c) 2026. The Author(s). FAU - Alotaibi, Naif Munawir AU - Alotaibi NM AUID- ORCID: 0009-0002-2383-3462 AD - Orthodontic Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. dr.naifmo@gmail.com. FAU - Kamel, Ahmed Mohamed AU - Kamel AM AUID- ORCID: 0000-0003-1940-5270 AD - Orthodontic Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. FAU - Khalil, Abeer Twakol AU - Khalil AT AUID- ORCID: 0000-0003-4223-2144 AD - Department of Electronic and Communication Engineering, Faculty of Engineering, Mansoura University, Mansoura, Egypt. FAU - Hammad, Shaza Mohammad AU - Hammad SM AUID- ORCID: 0000-0002-6662-5068 AD - Orthodontic Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Cervical Vertebrae/growth & development/diagnostic imaging MH - *Cephalometry/methods MH - Child MH - Adolescent MH - *Deep Learning MH - Convolutional Neural Networks MH - Female MH - *Age Determination by Skeleton/methods MH - Male PMC - PMC13289470 OTO - NOTNLM OT - Artificial intelligence OT - Cervical vertebral maturation OT - Skeletal classification. COIS- Declarations. Ethics approval and consent to participate: This study was approved by the dental research ethics committee of the Faculty of Dentistry at Mansoura University in Egypt (code no. A0703024OR) and conducted in accordance with the Declaration of Helsinki. The need for informed consent was waived by the committee due to the nature of the study and the anonymization of all data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/24 06:38 MHDA- 2026/06/24 18:35 PMCR- 2026/06/23 CRDT- 2026/06/24 00:06 PHST- 2025/11/12 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/06/24 18:35 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 00:06 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12903-026-08578-y [pii] AID - 8578 [pii] AID - 10.1186/s12903-026-08578-y [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 23;26(1):1107. doi: 10.1186/s12903-026-08578-y. PMID- 42337459 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260918 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Respiratory function profiling using non-invasive methods in children aged 7-18 years: a hospital based study from North India. LID - 10.1186/s12887-026-07138-1 [doi] LID - 842 AB - BACKGROUND: Respiratory health during childhood is crucial for optimal growth and long-term well-being. Early lung function impairment may remain clinically silent, yet predispose to chronic respiratory morbidity. While spirometry is the standard for assessing airway function, its routine use in children is often limited. Simple bedside tests such as Single Breath Count (SBC), Breath Holding Time (BHT), and Peak Expiratory Flow Rate (PEFR) are non-invasive, inexpensive, and feasible in outpatient and community settings, and may serve as practical screening tools for early detection of ventilatory dysfunction. METHODOLOGY: This hospital-based observational study was conducted in the Department of Pediatrics at a tertiary care teaching hospital in North-Western Uttar Pradesh after ethical approval and informed consent. Children aged 7-18 years attending the outpatient department were enrolled; those with acute respiratory illness or severe systemic disease were excluded. Anthropometry was recorded, and respiratory function was assessed using SBC, BHT, and PEFR following standardized protocols. These respiratory parameters were analyzed in relation to age, height, and BMI using descriptive and inferential statistical methods. RESULTS: Among 190 children (mean age 11.5 +/- 2.1 years), mean SBC, BHT, and PEFR were 32.4 +/- 12.9, 30.4 +/- 10.9, and 170.8 +/- 60.4 L/min, respectively. All respiratory parameters increased with age, with PEFR peaking at 13 years. SBC and BHT showed significant positive associations with PEFR; There was a statistically significant positive correlation between SBC, BHT, PEFR and anthropometric parameters. On regression analysis, age and height were found to significantly influence the PEFR reading. CONCLUSION: Breath-holding time and height are significant predictors of PEFR in children. Simple bedside respiratory measures, SBC and BHT, may serve as practical adjuncts for assessing pulmonary function in resource-limited settings. CI - (c) 2026. The Author(s). FAU - Mendiratta, Kashika AU - Mendiratta K AD - Department of Pediatrics, Sharda School of Medical Sciences & Research, Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India. FAU - Nair, Smita AU - Nair S AD - Department of Pediatrics, Sharda School of Medical Sciences & Research, Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India. FAU - Bothra, Meenakshi AU - Bothra M AUID- ORCID: 0000-0001-5144-5577 AD - Department of Pediatrics, Sharda School of Medical Sciences & Research, Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India. meenakshi.bothra@sharda.ac.in. FAU - Kalra, Aayushi AU - Kalra A AD - Jaipuria Institute of Management, Noida, India. LA - eng PT - Journal Article PT - Observational Study DEP - 20260623 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - India MH - Female MH - *Respiratory Function Tests/methods MH - Peak Expiratory Flow Rate MH - Spirometry PMC - PMC13555908 OTO - NOTNLM OT - Breath holding time (BHT) OT - Peak expiratory flow rate (PEFR) OT - Pediatric lung function OT - Pulmonary function screening OT - School-aged children OT - Single breath count (SBC) OT - Spirometry COIS- Declarations. Ethics approval and consent to participate: The study received approval from the institutional ethics committee, vide letter no. Ref.No. SU/SMS&R/76-A/2025/228 dated 05-08-2025. Informed consent was obtained from mothers before enrolment. Patient confidentiality was strictly maintained. Participation in the study did not affect the standard of care provided to patients. Consent for publication: No individual data or patient photos are being shared in this manuscript Competing interests: The authors declare no competing interests. EDAT- 2026/06/24 06:39 MHDA- 2026/09/09 11:38 PMCR- 2026/06/23 CRDT- 2026/06/24 00:04 PHST- 2026/02/23 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/06/24 06:39 [pubmed] PHST- 2026/06/24 00:04 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12887-026-07138-1 [pii] AID - 7138 [pii] AID - 10.1186/s12887-026-07138-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 23;26(1):842. doi: 10.1186/s12887-026-07138-1. PMID- 42337032 OWN - NLM STAT- Publisher LR - 20260811 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 23 TI - Serum FAM132A/Adipolin correlates with endothelial dysfunction in children with obesity. LID - 10.1038/s41390-026-05240-9 [doi] AB - BACKGROUND: Early cardiovascular risk in children demands biomarkers linking adiposity to vascular injury. We examined whether serum FAM132A (Adipolin) associates with endothelial dysfunction markers in Chinese children with obesity. METHODS: In a STROBE-guided single-center case-control study (Sep 2023-Mar 2024), we enrolled 82 children with obesity and 50 age-matched normal-weight controls; all participants underwent clinical assessment and anthropometry, and serum FAM132A, adiponectin, leptin and endothelial markers VCAM-1, E-selectin and ESM-1 were measured by ELISA. Multiple linear regression tested independent associations with adjustment for age, sex, pubertal stage, HOMA-IR and leptin. RESULTS: Mean FAM132A was higher in the obesity group (0.97 +/- 0.13 vs 0.79 +/- 0.07 ng/ml, p < 0.001) and correlated positively with BMI, SDS-BMI, WHR, ALT and the three endothelial markers. In fully adjusted models FAM132A independently predicted VCAM-1 (beta = 1.110, p = 0.040), E-selectin (beta = 1.210, p = 0.043) and ESM-1 (beta = 1.257, p = 0.041); these associations persisted after accounting for insulin resistance and were independent of classic adipokines. CONCLUSION: Serum FAM132A is paradoxically elevated in pediatric obesity and independently associated with endothelial activation, suggesting compensatory upregulation in early metabolic stress and potential utility as an early vascular injury biomarker and merits longitudinal validation. IMPACT: Serum FAM132A elevated in obese Chinese children. FAM132A correlates with endothelial markers VCAM-1, E-selectin, and ESM-1. Associations independent of insulin resistance and classic adipokines. Suggests compensatory upregulation during early metabolic stress. IMPLICATION: FAM132A as early biomarker for pediatric vascular injury. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Jin, Yan AU - Jin Y AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Department of Neonatology, Shaanxi Sen-gong Hospital, Xi'an, Shaanxi, China. FAU - Ding, Yi AU - Ding Y AD - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Li, Hua AU - Li H AD - Preventive Healthcare Department, Xi'an Children's Hospital, Xi'an, Shaanxi, China. FAU - Lian, Biyao AU - Lian B AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Wu, Xiaokang AU - Wu X AD - Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi 'an, Shaanxi, China. FAU - Gao, Ning AU - Gao N AD - Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi 'an, Shaanxi, China. FAU - Zhang, Wen AU - Zhang W AD - Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi 'an, Shaanxi, China. FAU - Yin, Chunyan AU - Yin C AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. yinchunyan0624@163.com. LA - eng PT - Journal Article DEP - 20260623 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki. The study protocol was approved by the Institutional Ethics Committee of the Second Affiliated Hospital of Xi'an Jiaotong University (Approval No: 2023144). Written informed consent was obtained from the parents or legal guardians of all participants, and verbal assent was obtained from the children. EDAT- 2026/06/24 00:42 MHDA- 2026/06/24 00:42 CRDT- 2026/06/23 23:21 PHST- 2025/12/08 00:00 [received] PHST- 2026/05/17 00:00 [accepted] PHST- 2026/05/10 00:00 [revised] PHST- 2026/06/24 00:42 [pubmed] PHST- 2026/06/24 00:42 [medline] PHST- 2026/06/23 23:21 [entrez] AID - 10.1038/s41390-026-05240-9 [pii] AID - 10.1038/s41390-026-05240-9 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 23. doi: 10.1038/s41390-026-05240-9. PMID- 42336795 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260813 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Jun 23 TI - Mealtime behaviours, diet quality and parental stress in children with autism spectrum disorder: a cross-sectional study from Turkiye. LID - 10.1136/bmjpo-2025-004226 [doi] LID - e004226 AB - BACKGROUND: Feeding difficulties in children with Autism Spectrum Disorder (ASD) are prevalent, adversely affecting both the child's nutritional status and the family's psychosocial well-being. This study aimed to examine the interrelationships between mealtime behaviours, diet quality and parental stress in children with ASD. METHODS: A cross-sectional study was conducted with 111 parents of children diagnosed with ASD (mean age: 6.8+/-3.5 years) in Antalya, Turkiye. Data were collected via face-to-face interviews using validated tools (Brief Autism Mealtime Behaviour Inventory (BAMBI), parental mealtime strategies, parental stress scale, Quality of Life questionnaire in autism). Diet quality was evaluated using the Healthy Eating Index-2020, derived from 3-day food consumption records. Multivariate linear regression was used to identify independent predictors of diet quality. RESULTS: The prevalence of poor diet quality was alarmingly high (94.5%). Multivariate regression revealed that problematic mealtime behaviours (BAMBI) were a strong independent predictor of lower diet quality (B=-0.370, p<0.001), even after adjusting for sociodemographic factors. While overall proactive parental strategies positively predicted diet quality, specific accommodative practices like preparing special meals correlated negatively. Furthermore, caregivers of girls reported significantly higher stress (p=0.017) and perceived autism-related burden (p=0.003) compared with caregivers of boys. CONCLUSIONS: Severe mealtime behavioural dysregulation in ASD intrinsically compromises diet quality and elevates parental psychosocial burden. Clinical management requires a multidisciplinary, family-centred approach integrating behavioural feeding support with caregiver stress management. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Ozyildirim, Caner AU - Ozyildirim C AUID- ORCID: 0000-0001-8227-9575 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Karacil Ermumcu, Merve Seyda AU - Karacil Ermumcu MS AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Mutlu, Meryem Ece AU - Mutlu ME AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Baran, Ilgin AU - Baran I AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Salim, Hediye AU - Salim H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Seremet Kurklu, Nilgun AU - Seremet Kurklu N AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey nseremetkurklu@akdeniz.edu.tr. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - *Autism Spectrum Disorder/psychology MH - Child MH - *Stress, Psychological/epidemiology MH - *Feeding Behavior/psychology MH - *Parents/psychology MH - *Meals/psychology MH - Child, Preschool MH - Quality of Life MH - Surveys and Questionnaires MH - *Diet PMC - PMC13295970 OTO - NOTNLM OT - Child Health COIS- Competing interests: None declared. EDAT- 2026/06/24 00:43 MHDA- 2026/06/24 18:35 PMCR- 2026/06/23 CRDT- 2026/06/23 22:33 PHST- 2025/10/30 00:00 [received] PHST- 2026/05/30 00:00 [accepted] PHST- 2026/06/24 18:35 [medline] PHST- 2026/06/24 00:43 [pubmed] PHST- 2026/06/23 22:33 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-004226 [pii] AID - bmjpo-2025-004226 [pii] AID - 10.1136/bmjpo-2025-004226 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Jun 23;10(1):e004226. doi: 10.1136/bmjpo-2025-004226. PMID- 42336570 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260624 IS - 1001-0742 (Print) IS - 1001-0742 (Linking) VI - 166 DP - 2026 Aug TI - Associations between prenatal exposure to indoor air pollution and ambient particulate matter with infant growth. PG - 648-657 LID - S1001-0742(26)00041-0 [pii] LID - 10.1016/j.jes.2026.01.042 [doi] AB - Despite growing concern, the developmental effects of prenatal exposure to indoor and ambient particulate pollution remain poorly characterized. This study examined their individual and joint associations with infant growth. Embedded in the PKUBC-T birth cohort (initiated in June 2018, China), this study included 1068 mother-infant pairs. The PM(1) and PM(2.5) concentrations from the last menstrual period to delivery were predicted via a validated machine learning model, whereas PM(2.5) constituents' concentrations were derived via a modified Community Multiscale Air Quality Model. Indoor air pollution was assessed via questionnaires covering four dimensions. Infant growth was evaluated using body mass index (BMI) Z-scores and weight-for-length (WFL) Z-scores at one year, with overweight/obesity (OWOB) defined by World Health Organization standards. Generalized linear regression indicated that increased exposure to indoor air pollution was associated with elevated BMI Z-scores (beta = 0.089, 95 % CI: 0.007, 0.171) and WFL Z-scores (beta = 0.094, 95 % CI: 0.013, 0.176) in offspring. PM(1) and PM(2.5) also exhibited positive associations with these growth indicators. Infants whose mothers were exposed to higher levels of organic carbon (OC), elementary carbon (EC), NH(4)(+) and SO(4)(2-) had an elevated risk of overweight/obesity (OWOB). Stratified analyses revealed that joint exposure to PM(1) above the median and indoor air pollution was related to increased infant growth, despite nonsignificant multiplicative interaction effects. Similar joint effects were observed for indoor air pollution and PM(2.5), along with its constituents. This study highlights synergistic harms of combined indoor-outdoor air pollution on infant growth, reinforcing the need for integrated policies targeting indoor combustion and ambient PM reduction to safeguard early-life development. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Lyu, Jinlang AU - Lyu J AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Li, Tiantian AU - Li T AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. FAU - Zhou, Shuang AU - Zhou S AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China. FAU - Yuan, Xin AU - Yuan X AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Bao, Zheng AU - Bao Z AD - Tongzhou Maternal and Child Health Care Hospital of Beijing, Beijing 101101, China. FAU - Han, Na AU - Han N AD - Tongzhou Maternal and Child Health Care Hospital of Beijing, Beijing 101101, China. FAU - Chen, Gongbo AU - Chen G AD - Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne 3800, Australia. FAU - Ji, Yuelong AU - Ji Y AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Li, Qin AU - Li Q AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Liu, Jue AU - Liu J AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Hui AU - Wang H AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Hu, Jianlin AU - Hu J AD - Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Nanjing University of Information Science & Technology, Nanjing 210044, China. FAU - Liu, Ting AU - Liu T AD - Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Nanjing University of Information Science & Technology, Nanjing 210044, China. FAU - Guo, Yuming AU - Guo Y AD - Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne 3800, Australia. FAU - Li, Yan AU - Li Y AD - Research Center for Child Health, Department of Child Health Care, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Qingdao, Shandong 250014, China. FAU - Wang, Hai-Jun AU - Wang HJ AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. Electronic address: whjun@pku.edu.cn. LA - eng PT - Journal Article DEP - 20260120 PL - Netherlands TA - J Environ Sci (China) JT - Journal of environmental sciences (China) JID - 100967627 RN - 0 (Particulate Matter) RN - 0 (Air Pollutants) SB - IM MH - Humans MH - *Particulate Matter/analysis/adverse effects MH - *Air Pollution, Indoor/statistics & numerical data/adverse effects MH - Female MH - *Maternal Exposure/statistics & numerical data MH - *Air Pollutants/analysis MH - Infant MH - China/epidemiology MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/epidemiology MH - *Child Development/drug effects OTO - NOTNLM OT - Adiposity OT - Air pollution OT - Indoor OT - Infant OT - PM(1) OT - PM(2.5) COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/24 00:45 MHDA- 2026/06/25 00:33 CRDT- 2026/06/23 20:54 PHST- 2025/07/17 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/17 00:00 [accepted] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/24 00:45 [pubmed] PHST- 2026/06/23 20:54 [entrez] AID - S1001-0742(26)00041-0 [pii] AID - 10.1016/j.jes.2026.01.042 [doi] PST - ppublish SO - J Environ Sci (China). 2026 Aug;166:648-657. doi: 10.1016/j.jes.2026.01.042. Epub 2026 Jan 20. PMID- 42336084 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260808 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 406 DP - 2026 Oct 1 TI - A family-based risk assessment of PBDE exposure using a multi-pathway approach: Integrating diet, dust, air and serum measurements. PG - 128627 LID - S0269-7491(26)00997-8 [pii] LID - 10.1016/j.envpol.2026.128627 [doi] AB - A family-based, multi-matrix exposure assessment for polybrominated diphenyl ethers (PBDEs) was implemented to allow comparison of intake pathways and differentiation between shared household exposure and individual-level determinants. The study comprised 124 participants from 48 South Korean households (48 adolescents, 48 mothers and 28 fathers). PBDEs were analysed in indoor air and dust samples per household, three-day whole-meal composite dietary samples and serum per individual, with sampling conducted between August 2020 and January 2021. Dietary intake was the dominant intake pathway, contributing a median of 85.3% of total summation operatorPBDE estimated daily intake (EDI), followed by dust ingestion (11.9%), air inhalation (1.06%), and dermal absorption (0.026%). Median total EDIs were highest for adolescents (4940 pg/kg body weight/day), followed by fathers (3560 pg/kg bw/day) and mothers (2970 pg/kg bw/day), without significant differences. Exposure variability was primarily individual rather than family-based, with family membership explaining approximately 19% of variability (intraclass correlation coefficient = 0.19). Within families, the median ratio between the highest and lowest exposed individuals was 3.8 and exceeded 10 in the upper quartile. Total EDIs were dominated by higher-brominated congeners, particularly BDE-209, whereas serum profiles showed lower representation of BDE-209, reflecting the differences between short-term intake and longer-term accumulation. Mixture risk characterization using the European Food Safety Authority margin of exposure framework suggested limited population-level health concern. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - McGrath, Thomas J AU - McGrath TJ AD - Institute of Health and Environment, Seoul National University, Seoul, 08826, Republic of Korea. FAU - Mok, Sori AU - Mok S AD - Department of Marine Science and Convergence Technology, Hanyang University ERICA, Ansan, 15588, Republic of Korea. FAU - Lim, Jae-Eun AU - Lim JE AD - Department of Marine Science and Convergence Technology, Hanyang University ERICA, Ansan, 15588, Republic of Korea. FAU - Park, Jeongim AU - Park J AD - Department of Environmental Health Sciences, Soonchunhyang University, Asan, 31538, Republic of Korea. FAU - Choi, Kyungho AU - Choi K AD - Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea. FAU - Kho, Younglim AU - Kho Y AD - Department of Health, Environment & Safety, Eulji University, Seongnam, 13135, Republic of Korea. FAU - Kim, Sungkyoon AU - Kim S AD - Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea. FAU - Moon, Hyo-Bang AU - Moon HB AD - Department of Marine Science and Convergence Technology, Hanyang University ERICA, Ansan, 15588, Republic of Korea. Electronic address: hbmoon@hanyang.ac.kr. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Halogenated Diphenyl Ethers) RN - 0 (Dust) RN - 0 (Environmental Pollutants) RN - 0 (Air Pollutants) SB - IM MH - *Halogenated Diphenyl Ethers/analysis/blood MH - Humans MH - *Dust/analysis MH - Risk Assessment MH - Diet MH - *Environmental Exposure/statistics & numerical data/analysis MH - Republic of Korea MH - Male MH - Adult MH - Female MH - Adolescent MH - Environmental Monitoring MH - *Environmental Pollutants/analysis MH - *Dietary Exposure MH - Air Pollutants/analysis OTO - NOTNLM OT - Human biomonitoring OT - Margin of exposure OT - Multi-pathway exposure OT - Persistent organic pollutants OT - Polybrominated diphenyl ethers (PBDEs) COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/24 00:42 MHDA- 2026/08/08 23:08 CRDT- 2026/06/23 19:32 PHST- 2026/03/25 00:00 [received] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/08/08 23:08 [medline] PHST- 2026/06/24 00:42 [pubmed] PHST- 2026/06/23 19:32 [entrez] AID - S0269-7491(26)00997-8 [pii] AID - 10.1016/j.envpol.2026.128627 [doi] PST - ppublish SO - Environ Pollut. 2026 Oct 1;406:128627. doi: 10.1016/j.envpol.2026.128627. Epub 2026 Jun 23. PMID- 42335465 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260904 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Jun 23 TI - Different Dimensions of Social Support on Social Media and Leisure-Time Physical Activity Intentions Among Chinese College Students Applying the Theory of Planned Behavior: A Cross-Sectional Study. PG - e90020 LID - 10.2196/90020 [doi] LID - e90020 AB - BACKGROUND: Leisure-time physical activity (LTPA) participation among Chinese college students remains insufficient despite growing public health concerns regarding sedentary lifestyles and obesity. Social media platforms have increasingly become important channels for delivering social support related to physical activity (PA); however, different dimensions of social support on social media may exert distinct psychological influences on exercise intentions. OBJECTIVE: Guided by the theory of planned behavior, this study aimed to examine the direct and indirect relationships between different dimensions of social support on social media and Chinese college students' intentions to engage in LTPA. METHODS: A cross-sectional online survey was conducted among undergraduate and graduate students from a comprehensive university in East China between February and June 2022. A total of 310 valid responses were analyzed using structural equation modeling in R. Three dimensions of social support on social media, including companionship support, informational support, and self-esteem support, were examined as predictors of LTPA intention, with the theory of planned behavior constructs (attitude, subjective norms, and perceived behavioral control) modeled as mediators. Demographic characteristics, BMI, social media use, and prior PA behaviors were included as covariates. RESULTS: Companionship support demonstrated the strongest positive association with LTPA intention, including both a direct effect (beta=.348; P=.005) and an indirect effect through attitudes toward PA (beta=.286; P=.002). Self-esteem support also showed a significant positive indirect association with LTPA intention via attitude (beta=.138; P=.02). In contrast, informational support demonstrated a significant negative indirect effect on LTPA intention through attitude (beta=-.291; P<.001). Subjective norms and perceived behavioral control did not significantly mediate the relationships between social support dimensions and LTPA intention. The findings suggest that companionship-oriented interactions on social media may strengthen positive exercise attitudes, whereas excessive or low-credibility informational content may undermine exercise motivation. CONCLUSIONS: Different dimensions of social support on social media play distinct roles in shaping Chinese college students' intentions to engage in LTPA. Social media-based PA interventions should prioritize companionship and esteem support while improving the credibility, personalization, and quality of informational support to reduce potential negative effects associated with misinformation and information overload. CI - (c) Ni Zhang, Carolyn Madison Chang, Yu Zhang, Lu Guo, Qizhi Xu. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Zhang, Ni AU - Zhang N AUID- ORCID: 0000-0002-1811-2655 AD - Department of Public Health, San Jose State University, San Jose, CA, United States. FAU - Chang, Carolyn Madison AU - Chang CM AUID- ORCID: 0009-0008-5244-9383 AD - Department of Public Health, San Jose State University, San Jose, CA, United States. FAU - Zhang, Yu AU - Zhang Y AUID- ORCID: 0009-0006-4478-3088 AD - Department of Communication of Science and Technology, School of Humanities and Social Sciences, University of Science and Technology of China, 96# Jinzhai Road, Hefei, Anhui, 230026, China, 86 13155108598. FAU - Guo, Lu AU - Guo L AUID- ORCID: 0009-0006-6448-419X AD - School of Literature and Arts, Southwest University of Science and Technology, Mianyang, Sichuan, China. FAU - Xu, Qizhi AU - Xu Q AUID- ORCID: 0009-0002-9578-783X AD - Department of Communication of Science and Technology, School of Humanities and Social Sciences, University of Science and Technology of China, 96# Jinzhai Road, Hefei, Anhui, 230026, China, 86 13155108598. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260623 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Female MH - Theory of Planned Behavior MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - *Exercise/psychology MH - China MH - Universities/organization & administration MH - Male MH - *Social Media/statistics & numerical data/standards MH - *Social Support MH - *Intention MH - *Leisure Activities/psychology MH - Young Adult MH - Adult MH - Surveys and Questionnaires MH - Adolescent PMC - PMC13290102 OTO - NOTNLM OT - Chinese college students OT - TPB OT - companionship support OT - esteem support OT - informational support OT - leisure-time physical activities OT - social support on social media OT - theory of planned behavior COIS- Conflicts of Interest: None declared. EDAT- 2026/06/23 18:33 MHDA- 2026/06/23 18:34 PMCR- 2026/06/23 CRDT- 2026/06/23 17:02 PHST- 2025/12/20 00:00 [received] PHST- 2026/06/03 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 18:33 [pubmed] PHST- 2026/06/23 17:02 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - v10i1e90020 [pii] AID - 90020 [pii] AID - 10.2196/90020 [doi] PST - epublish SO - JMIR Form Res. 2026 Jun 23;10:e90020. doi: 10.2196/90020. PMID- 42335426 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260813 IS - 1473-5687 (Electronic) IS - 0954-691X (Linking) VI - 38 IP - 8 DP - 2026 Aug 1 TI - Association between albumin-bilirubin score, model for end-stage liver disease score, platelet-albumin-bilirubin score, and acute-on-chronic liver failure complications: a cross-sectional study in a Chinese population. PG - 959-970 LID - 10.1097/MEG.0000000000003221 [doi] AB - BACKGROUND AND AIMS: Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation and high short-term mortality. We investigated whether the albumin-bilirubin (ALBI) score, model for end-stage liver disease (MELD) score, and platelet-albumin-bilirubin (PALBI) score independently predict major ACLF complications. METHODS: This retrospective cross-sectional study enrolled 2104 ACLF patients (2017-2024) fulfilling Asian Pacific Association for the Study of the Liver 2019 criteria. ALBI, MELD, and PALBI were calculated within 48 h of admission. Multivariable logistic regression, restricted cubic spline, and receiver operating characteristic (ROC) analyses assessed associations with ascites, hepatic encephalopathy, hepatorenal syndrome (HRS), coagulopathy, splenomegaly, and spontaneous bacterial peritonitis. RESULTS: All three scores increased significantly with worsening Child-Pugh class (P < 0.001). Per SD increase, ALBI predicted all six complications with adjusted odds ratios (ORs) ranging from 1.98 to 8.73. MELD showed similar predictive ability (ORs: 2.58-7.26). PALBI quartiles 2 and 3 remained significantly associated with HRS (P = 0.007 and P = 0.011, respectively). Restricted cubic spline revealed nonlinear dose-response relationships (P-nonlinearity < 0.005). ROC area under the curve values were consistently higher for MELD than ALBI and PALBI. Subgroup analyses confirmed stability across age, sex, BMI, smoking, and alcohol use. CONCLUSION: ALBI, MELD, and PALBI scores simply and reliably identify ACLF complications, helping clinicians intensify monitoring and tailor therapy for high-risk patients. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Xie, Jiejie AU - Xie J AD - Department of Gastroenterology. FAU - Pei, Xiong AU - Pei X AD - Department of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan. FAU - Wang, Longyan AU - Wang L AD - Department of Gastroenterology. FAU - Ma, Xiaopu AU - Ma X AD - Department of Gastroenterology, Affiliated Hospital of Xizang Minzu University, Xianyang City, Shaanxi, China. FAU - Xie, Yan AU - Xie Y AD - Department of Gastroenterology. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - Eur J Gastroenterol Hepatol JT - European journal of gastroenterology & hepatology JID - 9000874 RN - RFM9X3LJ49 (Bilirubin) RN - 0 (Serum Albumin) RN - 0 (Biomarkers) RN - Chinese people SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - *Acute-On-Chronic Liver Failure/blood/complications/diagnosis MH - Retrospective Studies MH - *Bilirubin/blood MH - Middle Aged MH - China/epidemiology MH - Severity of Illness Index MH - *Serum Albumin MH - Predictive Value of Tests MH - ROC Curve MH - Platelet Count MH - Hepatorenal Syndrome/etiology MH - Risk Factors MH - Biomarkers/blood MH - Adult MH - Aged MH - Prognosis MH - Ascites/etiology MH - East Asian People OTO - NOTNLM OT - Albumin-Bilirubin score OT - Chinese cohort OT - Platelet-Albumin-Bilirubin Index score OT - ROC analysis OT - ascites OT - hepatic encephalopathy OT - hepatorenal syndrome OT - model for end-stage liver disease score OT - restricted cubic spline OT - spontaneous bacterial peritonitis OT - threshold effect EDAT- 2026/06/23 18:33 MHDA- 2026/06/23 18:34 CRDT- 2026/06/23 16:03 PHST- 2025/11/15 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 18:33 [pubmed] PHST- 2026/06/23 16:03 [entrez] AID - 00042737-202608000-00009 [pii] AID - 10.1097/MEG.0000000000003221 [doi] PST - ppublish SO - Eur J Gastroenterol Hepatol. 2026 Aug 1;38(8):959-970. doi: 10.1097/MEG.0000000000003221. Epub 2026 Jun 25. PMID- 42335179 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Predicting elevated transcranial doppler velocity among patients with sickle cell anemia in Uganda: A cross-sectional study. PG - e0351700 LID - 10.1371/journal.pone.0351700 [doi] LID - e0351700 AB - BACKGROUND: Sickle cell anemia (SCA) is an autosomal recessive blood disorder resulting from a specific point mutation in the beta-globin gene. Over half a million children are born with sickle cell anemia annually. Transcranial Doppler (TCD) velocity is an accurate predictor of the risk of stroke among children with sickle cell anemia. Unfortunately, TCD screening is not routinely done in developing countries due to limited resources. There is a need to develop a model that predicts elevated TCD velocity, utilizing routinely collected data to guide management of children with sickle cell anemia. METHODS: We conducted a cross-sectional study from 1st July 2024-30th August 2024 among children with SCA attending the Sickle Cell Clinic. We developed a risk-prediction model for elevated TCD (>/= 170 cm/s) using sociodemographic, hematological, and clinical factors. We used the least absolute shrinkage and selection operator (LASSO) penalized regression to select the best subset of predictors of increased TCD velocity. Model performance was assessed by determining the discrimination using the area under the curve and calibration by drawing a calibration plot. RESULTS: We enrolled 385 children; the mean age was 10.3 (SD 3.8) years. The prevalence of elevated TCD, defined as >/=170 cm/s was 8.3% (95% CI: 5.8, 11.5; n = 32/385). Using a lambda of 0.008, the final model had 12 predictors. The predictors included neuropathy, red blood cell count, heart rate, age, adherence to hydroxyurea, headache, hematocrit, serum lactate dehydrogenase, gender, malnutrition, blood transfusion, and neutrophils. The model predicted elevated TCD with an AUC of 84.7% (95%CI: 74.7, 90.8). CONCLUSION: We developed and validated a model to predict elevated TCD among children living with SCA in Uganda. Further exploration is needed to assess whether this model predicts stroke. CI - Copyright: (c) 2026 Nayiga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Nayiga, Doreen AU - Nayiga D AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Mukunya, David AU - Mukunya D AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Odoch, Simon AU - Odoch S AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Oguttu, Faith AU - Oguttu F AUID- ORCID: 0009-0006-7481-3321 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Munabi, Ian AU - Munabi I AD - Department of Anatomy, Makerere University, Kampala, Uganda. FAU - Musaba, Milton W AU - Musaba MW AD - Department of Obstetrics and Gynecology, Busitema University, Mbale, Uganda. FAU - Kimbugwe, Charles AU - Kimbugwe C AD - Mbale regional referral hospital, Mbale, Uganda. FAU - Makoko, Brian Tonny AU - Makoko BT AUID- ORCID: 0000-0002-6254-4797 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Babuya, Jonathan AU - Babuya J AUID- ORCID: 0000-0001-7586-3386 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Mugabi, Joshua AU - Mugabi J AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Nyalihama, Alain AU - Nyalihama A AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Chebet, Martin AU - Chebet M AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Rynn, Lisa AU - Rynn L AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Kizito, Samuel AU - Kizito S AD - Silver School of Social Work, New York University, New York, New York, United States of America. FAU - Ssentumbwe, Vincent AU - Ssentumbwe V AD - Division of Computational and Data Science, Washington University, St. Louis, Missouri, United States of America. FAU - Kiguli, Sarah AU - Kiguli S AD - Department of Pediatrics and Child Health, Makerere University, Kampala, Uganda. FAU - Olupot, Peter Olupot AU - Olupot PO AUID- ORCID: 0000-0002-5757-609X AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. LA - eng PT - Journal Article DEP - 20260623 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Anemia, Sickle Cell/diagnostic imaging/physiopathology/complications MH - Cross-Sectional Studies MH - Female MH - *Ultrasonography, Doppler, Transcranial/methods MH - Uganda/epidemiology MH - Male MH - Child MH - Blood Flow Velocity MH - Adolescent MH - Stroke/diagnostic imaging/etiology MH - Child, Preschool PMC - PMC13289871 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/23 18:34 MHDA- 2026/06/23 18:35 PMCR- 2026/06/23 CRDT- 2026/06/23 13:43 PHST- 2025/09/22 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/23 18:35 [medline] PHST- 2026/06/23 18:34 [pubmed] PHST- 2026/06/23 13:43 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - PONE-D-25-51516 [pii] AID - 10.1371/journal.pone.0351700 [doi] PST - epublish SO - PLoS One. 2026 Jun 23;21(6):e0351700. doi: 10.1371/journal.pone.0351700. eCollection 2026. PMID- 42335117 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260623 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 40 IP - 7 DP - 2026 Jul 1 TI - Improving Base Running Diagnostics With Foot Pod Technology: Intersession Reliability of Linear and Curvilinear Running Performance. PG - e714-e720 LID - 10.1519/JSC.0000000000005417 [doi] AB - Martinez-Rodriguez, JA, Crotin, RL, Neville, J, Barcelo, RA, and Cronin, JB. Improving base running diagnostics with foot pod technology: Intersession reliability of linear and curvilinear running performance. J Strength Cond Res 40(7): e714-e720, 2026-The purpose of this study was to determine the intersession reliability of foot pod technology for quantifying kinematic measures over the 54.7-m straight-line sprint (linear) and home-to-second base sprint (curvilinear). Twelve, trained male high school baseball position players, performed 3 identical sessions separated by at least 2 days. Eight kinematic measures (maximum speed, average speed and right and left ground contact time, stride length, push-off, and impact) were quantified over 2 linear and 2 curvilinear trials, which were divided into segments-home to first, first to second, and home to second, for a total of 60 comparisons across 3 testing occasions. There was no evidence (p > 0.05) of systematic change in any of the variables between sessions, with 91% of the mean percent changes <2%. In terms of absolute consistency, 94% of coefficients of variation (CVs) were under 10%, with 63% of the CVs under 5%. Regarding relative consistency, for the curvilinear segments 1 and 2, and total segment, 80, 56, and 80% of the between-session comparisons had intraclass correlation coefficients (ICC) greater than 0.74, respectively. The nonsignificant small percentage changes in the mean, low CVs, and good to excellent reliability of the ICCs for the most part indicate that foot pod technology can be used to reliably quantify linear and curvilinear base running performance measures with confidence. Consequently, this information can be used to better quantify base running efficiency and inform exercise prescription to improve base running performance. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - Martinez-Rodriguez, Jose Antonio AU - Martinez-Rodriguez JA AUID- ORCID: 0000-0001-8338-2873 AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. FAU - Crotin, Ryan L AU - Crotin RL AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. AD - Department of Kinesiology, Louisiana Tech University, Ruston, Louisiana. AD - ArmCare.com, Indialantic, Florida; and. FAU - Neville, Jonathon AU - Neville J AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. FAU - Barcelo, Roderick A AU - Barcelo RA AD - Athletic Department, Carlos Beltran Baseball Academy, Florida, Puerto Rico. FAU - Cronin, John B AU - Cronin JB AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. AD - Athlete Training and Health, Houston, Texas. LA - eng PT - Journal Article DEP - 20260304 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Running/physiology MH - Male MH - Biomechanical Phenomena MH - Reproducibility of Results MH - *Athletic Performance/physiology MH - Adolescent MH - *Baseball/physiology MH - Foot/physiology OTO - NOTNLM OT - high-frequency technology OT - kinematic measures EDAT- 2026/06/23 18:34 MHDA- 2026/06/23 18:35 CRDT- 2026/06/23 13:35 PHST- 2026/06/23 18:35 [medline] PHST- 2026/06/23 18:34 [pubmed] PHST- 2026/06/23 13:35 [entrez] AID - 00124278-202607000-00018 [pii] AID - 10.1519/JSC.0000000000005417 [doi] PST - ppublish SO - J Strength Cond Res. 2026 Jul 1;40(7):e714-e720. doi: 10.1519/JSC.0000000000005417. Epub 2026 Mar 4. PMID- 42334852 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260826 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 6 DP - 2026 Jun 1 TI - Maternal Cardiovascular Health During Pregnancy and Offspring Developmental Delay. PG - e2618804 LID - 10.1001/jamanetworkopen.2026.18804 [doi] LID - e2618804 AB - IMPORTANCE: Developmental delay affects daily living, social functioning, and mental health. Maternal cardiovascular health (CVH) during pregnancy may indicate an adverse intrauterine environment, but its association with developmental delay is unclear. OBJECTIVE: To examine the association between maternal CVH during pregnancy and developmental delay in offspring at 4 years of age. DESIGN, SETTING, AND PARTICIPANTS: This cohort study enrolled patients between July 19, 2013, and March 31, 2017, with 5 years of follow-up, at obstetric hospitals and clinics in Miyagi Prefecture, Japan. Participants included eligible mother and offspring pairs enrolled in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Offspring were followed up until age 4 years. Data analyses were conducted from November 12, 2024, to March 24, 2026. EXPOSURE: Maternal CVH during pregnancy, which was assessed using Life's Essential 8 metrics (diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure). Each metric was scored on a scale of 0 (least favorable) to 100 (most favorable), and these scores were used to categorize mothers as having high (80-100), moderate (50-79), or low (0-49) CVH. MAIN OUTCOMES AND MEASURES: Developmental delay at age 4 years, which was evaluated by the mother using the validated Japanese version of Ages and Stages Questionnaire, Third Edition. This instrument has 5 domains: communication, gross motor, fine motor, problem solving, and personal-social skills. Domain-specific delay was defined as 2 or more SDs below the mean score, and developmental delay in total was defined as delay in 1 or more of the 5 domains. RESULTS: Among 19 160 eligible mother and offspring pairs, 8238 (43.0%) were analyzed. Offspring were assessed at a mean (SD) age of 4.1 (0.2) years and included 4299 males (52.2%). Among mothers with high, moderate, and low CVH, 154 (8.8%), 763 (12.1%), and 33 (16.8%), respectively, had offspring with developmental delay in total. Compared with high CVH, moderate (risk ratio [RR], 1.30; 95% CI, 1.09-1.54) and low (RR, 1.62; 95% CI, 1.11-2.36) CVH during pregnancy were associated with developmental delay in total. Low CVH was associated with higher prevalence of developmental delay across all 5 domains, with personal-social domain having the largest effect size (RR, 2.23; 95% CI, 1.23-4.07; P for trend = .002) and communication domain having the smallest effect size (RR, 1.40; 95% CI, 0.69-2.85; P for trend = .03). CONCLUSIONS AND RELEVANCE: In this cohort study of mother and offspring pairs in Japan, better maternal CVH during pregnancy was associated with a lower risk of offspring developmental delay at age 4 years. FAU - Ohseto, Hisashi AU - Ohseto H AD - Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan. FAU - Ishikuro, Mami AU - Ishikuro M AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Chen, Geng AU - Chen G AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. FAU - Takahashi, Ippei AU - Takahashi I AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. FAU - Shinoda, Genki AU - Shinoda G AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Noda, Aoi AU - Noda A AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Miyagi, Japan. FAU - Murakami, Keiko AU - Murakami K AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Health and Social Behavior, School of Public Health, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. FAU - Orui, Masatsugu AU - Orui M AD - Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Takase, Masato AU - Takase M AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Iwama, Noriyuki AU - Iwama N AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Center for Maternal and Perinatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan. FAU - Kikuya, Masahiro AU - Kikuya M AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Hygiene and Public Health, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan. FAU - Metoki, Hirohito AU - Metoki H AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan. FAU - Hozawa, Atsushi AU - Hozawa A AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Epidemiology, School of Public Health, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. FAU - Obara, Taku AU - Obara T AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Miyagi, Japan. FAU - Kuriyama, Shinichi AU - Kuriyama S AD - Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260601 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Adult MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Pregnancy MH - Cohort Studies MH - *Developmental Disabilities/epidemiology/etiology MH - *Developmental Origins of Health and Disease/epidemiology MH - Japan/epidemiology MH - *Maternal Health/statistics & numerical data PMC - PMC13291893 COIS- Conflict of Interest Disclosures: Dr Ishikuro reported receiving grants from Japan Agency for Medical Research and Development and the Ministry of Education, Culture, Sports, Science, and Technology during the conduct of the study. No other disclosures were reported. EDAT- 2026/06/23 12:35 MHDA- 2026/06/23 18:34 PMCR- 2026/06/23 CRDT- 2026/06/23 11:33 PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 12:35 [pubmed] PHST- 2026/06/23 11:33 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 2850602 [pii] AID - zoi260523 [pii] AID - 10.1001/jamanetworkopen.2026.18804 [doi] PST - epublish SO - JAMA Netw Open. 2026 Jun 1;9(6):e2618804. doi: 10.1001/jamanetworkopen.2026.18804. PMID- 42334792 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20261010 IS - 2161-3311 (Electronic) IS - 2161-3311 (Linking) VI - 15 IP - 1 DP - 2026 Jun 23 TI - Dietary Interventions Targeting Maternal Obesity: Intergenerational Effects, Mechanisms, and Translational Insights. LID - 56 [pii] LID - 10.1007/s13668-026-00778-w [doi] AB - PURPOSE OF REVIEW: Maternal obesity is a major public health challenge that elevates pregnancy risks and predisposes offspring to lifelong metabolic disorders. Nutrition, as a modifiable determinant of the intrauterine environment, offers opportunities to interrupt this intergenerational cycle. This review synthesizes evidence on polyphenols, vitamins, omega-3 fatty acids, dietary fiber, probiotics, prebiotics, whole grains, and iron, highlighting underlying mechanisms and translational implications for maternal and offspring health. RECENT FINDINGS: Preclinical studies demonstrate that these interventions improve maternal metabolism, modulate placental function, regulate gut microbiota, alter breast milk composition, and influence epigenetic programming. Clinical evidence is relatively strong for folic acid and vitamin D, whereas evidence for dietary fiber is emerging, with long-term offspring outcomes still insufficiently investigated. Polyphenols and omega-3 fatty acids exert antioxidant and anti-inflammatory effects, but translation is constrained by low bioavailability and limited safety data. Probiotics and prebiotics show potential in modulating maternal-infant gut health, yet trial outcomes are inconsistent and strain-specific. Whole grains and fortified foods may represent feasible options for population-level implementation, although robust longitudinal studies in obese pregnancies are still lacking. Dietary interventions hold promise for mitigating maternal obesity by improving metabolism, reducing inflammation, supporting placental function, and modulating gut microbiota, breast milk composition, and epigenetic programming. However, evidence is largely preclinical and long-term human data are limited. Future research should prioritize well-designed clinical trials and personalized approaches tailored to maternal phenotype and nutritional status to enable effective, scalable strategies for breaking the intergenerational cycle of obesity. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Li, Xiaolin AU - Li X AD - College of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001, China. AD - Food Laboratory of Zhongyuan, Henan University of Technology, Zhengzhou, 450001, China. FAU - Liu, Ming AU - Liu M AD - College of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001, China. AD - Food Laboratory of Zhongyuan, Henan University of Technology, Zhengzhou, 450001, China. FAU - Liao, Aimei AU - Liao A AD - Food Laboratory of Zhongyuan, Henan University of Technology, Zhengzhou, 450001, China. FAU - Pan, Long AU - Pan L AD - Food Laboratory of Zhongyuan, Henan University of Technology, Zhengzhou, 450001, China. FAU - Liu, Jin AU - Liu J AD - Systems Engineering Institute, Beijing, 100010, China. FAU - Zhou, Jingbo AU - Zhou J AD - Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, 510642, China. zhoujingbo@gdaas.cn. FAU - Huang, Jihong AU - Huang J AD - College of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001, China. huangjih1216@126.com. AD - State Key Laboratory of Crop Stress Adaptation and Improvement, College of Agriculture, Henan University, Kaifeng, 475004, China. huangjih1216@126.com. AD - Food Laboratory of Zhongyuan, Henan University of Technology, Zhengzhou, 450001, China. huangjih1216@126.com. LA - eng GR - Z20221341069 and Z20231811012/Central Government Guides the Local Science and Technology Development Special Fund/ PT - Journal Article PT - Review DEP - 20260623 PL - United States TA - Curr Nutr Rep JT - Current nutrition reports JID - 101587480 RN - 0 (Prebiotics) RN - 0 (Dietary Fiber) RN - 0 (Fatty Acids, Omega-3) RN - 0 (Polyphenols) RN - 0 (Vitamins) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pregnancy in Obesity/diet therapy MH - Prebiotics/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - Probiotics/administration & dosage MH - *Diet MH - Dietary Fiber/administration & dosage MH - Developmental Origins of Health and Disease MH - Gastrointestinal Microbiome MH - Fatty Acids, Omega-3/administration & dosage MH - Polyphenols/administration & dosage MH - Animals MH - Epigenesis, Genetic MH - Vitamins/administration & dosage OTO - NOTNLM OT - Dietary interventions OT - Gut microbiota OT - Maternal obesity OT - Offspring OT - Placenta COIS- Declarations. Competing interests: The authors declare no competing interests. Human and Animal Rights and Informed Consent: This article does not contain any studies with human or animal subjects performed by any of the authors. EDAT- 2026/06/23 12:35 MHDA- 2026/06/23 18:33 CRDT- 2026/06/23 11:22 PHST- 2025/09/11 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/23 18:33 [medline] PHST- 2026/06/23 12:35 [pubmed] PHST- 2026/06/23 11:22 [entrez] AID - 10.1007/s13668-026-00778-w [pii] AID - 10.1007/s13668-026-00778-w [doi] PST - epublish SO - Curr Nutr Rep. 2026 Jun 23;15(1):56. doi: 10.1007/s13668-026-00778-w. PMID- 42334665 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20261010 IS - 1534-3170 (Electronic) IS - 1523-3782 (Linking) VI - 28 IP - 1 DP - 2026 Jun 23 TI - Diagnosis and Management of Loeys-Dietz Syndrome: Evidence Gaps and Future Directions. LID - 61 [pii] LID - 10.1007/s11886-026-02383-3 [doi] AB - PURPOSE OF REVIEW: This review summarizes current knowledge on Loeys-Dietz syndrome (LDS), including its genetic basis, multisystem manifestations, diagnosis, surveillance, and management. It also highlights key evidence gaps in risk stratification, medical therapy, imaging surveillance, surgical thresholds, and care of pregnant and pediatric patients. RECENT FINDINGS: Although understanding of the genetic basis and clinical spectrum of LDS has improved, LDS-specific evidence remains limited. LDS is increasingly recognized as a multisystem disorder with aggressive aortic disease, extra-aortic vascular involvement, skeletal, craniofacial, allergic, gastrointestinal, and neurodevelopmental manifestations. Current recommendations are largely based on expert consensus and experience with related connective tissue disorders. Most available research focuses on the aortic root and ascending aorta, with less evidence guiding management of peripheral vascular disease. LDS requires early diagnosis, individualized risk assessment, and multidisciplinary longitudinal care supported by genetic evaluation, biomarker-based approaches, multimodality imaging, and structured surveillance. Future research should focus on multicenter registries, genotype-phenotype correlations, biomarker validation, advanced imaging, and LDS-specific therapeutic studies to develop evidence-based guidelines and improve long-term outcomes. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Abdalla, Hesham M AU - Abdalla HM AD - Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA. FAU - Abdelnabi, Mahmoud AU - Abdelnabi M AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. Abdelnabi.Mahmoud@mayo.edu. FAU - Khedr, Ahmed AU - Khedr A AD - Department of Cardiovascular Surgery, Mayo Clinic, Phoenix, AZ, USA. FAU - Jamal, Fares AU - Jamal F AD - Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ, USA. FAU - Nwaezeapu, Karldon Iwuchukwu AU - Nwaezeapu KI AD - Department of Internal Medicine, Trintiy Health, Ann Arbor, MI, USA. FAU - Raslan, Mohammed Alaa AU - Raslan MA AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Ibrahim, Ramzi AU - Ibrahim R AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Pham, Hoang Nhat AU - Pham HN AD - Department of Medicine, University of Arizona, Tucson, AZ, USA. AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Pathangey, Girish AU - Pathangey G AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Abdul Nabi, Hussein AU - Abdul Nabi H AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Dreher, Luke AU - Dreher L AD - Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA. FAU - Osundiji, Mayowa A AU - Osundiji MA AD - Department of Clinical Genomics, Mayo Clinic, Scottsdale, AZ, 85259, USA. FAU - Coutinho, Thais D AU - Coutinho TD AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Arsanjani, Reza AU - Arsanjani R AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Shamoun, Fadi AU - Shamoun F AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Ayoub, Chadi AU - Ayoub C AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. LA - eng PT - Journal Article PT - Review DEP - 20260623 PL - United States TA - Curr Cardiol Rep JT - Current cardiology reports JID - 100888969 SB - IM MH - Humans MH - *Loeys-Dietz Syndrome/diagnosis/therapy/genetics MH - Female MH - Pregnancy MH - Risk Assessment OTO - NOTNLM OT - Aortic aneurysm OT - Aortic dissection OT - Aortopathies OT - Loeys-dietz syndrome OT - Management OT - Non-skeletal manifestations OT - Pediatric considerations OT - Pregnancy OT - Surveillance OT - TGF-beta signaling COIS- Declarations. Competing interests: The authors declare no competing interests. Human and Animal Rights and Informed Consent: This article does not contain any studies with human, or animal subjects performed by any of the authors. EDAT- 2026/06/23 12:36 MHDA- 2026/06/23 18:34 CRDT- 2026/06/23 11:18 PHST- 2026/06/02 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 12:36 [pubmed] PHST- 2026/06/23 11:18 [entrez] AID - 10.1007/s11886-026-02383-3 [pii] AID - 10.1007/s11886-026-02383-3 [doi] PST - epublish SO - Curr Cardiol Rep. 2026 Jun 23;28(1):61. doi: 10.1007/s11886-026-02383-3. PMID- 42334526 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 2210-6014 (Electronic) IS - 2210-6006 (Print) IS - 2210-6006 (Linking) VI - 16 IP - 1 DP - 2026 Jun 23 TI - Anemia and Cardiometabolic Risk in Indian University Students: Findings from a Health Screening Program. LID - 10.1007/s44197-026-00597-w [doi] LID - 111 AB - BACKGROUND: College students represent a population that is considered clinically at low risk; yet, early adulthood constitutes a crucial time point when nutritional and metabolic risks manifest themselves. This retrospective observational study evaluated anemia, blood pressure, and body mass index (BMI) characteristics of college students undergoing a health screening examination organized by their university in India. METHODS: Anonymized electronic health records were analyzed for 13,628 college students between the ages of 18 and 30 years old attending annual health screening from 1 June 2023 to 31 May 2024. The sample consisted of 77.2% of the eligible students. BMI, blood pressure, and hemoglobin levels were classified according to international standards. Gender-based differences were explored through chi-square tests and Cramer's V measures. Association between anemia and screening-confirmed hypertension was assessed using Pearson correlations and multiple logistic regression. In addition, model discrimination, calibration, classification parameters, and internal validation were evaluated. RESULTS: There were 7,012 (51.5%) female students and 6,616 (48.5%) male students in the sample population. In total, 47.3% of the students were either overweight or obese, 8,081 (59.3%) fulfilled the criteria for high blood pressure according to the ACC/AHA guidelines, while 7,227 (53.0%) fulfilled WHO guidelines for anemia based on gender. Hypertension screening was also more common among men (66.6%) compared to women (52.4%; p < 0.001). In the adjusted models, being male was significantly linked with anemia and hypertension screening, while being overweight was significantly linked with hypertension screening. CONCLUSION: This study showed the high prevalence of undiagnosed anemia and cardiometabolic risks among university students, suggesting the importance of health promoting universities in systematic screening programs and follow-ups. CI - (c) 2026. The Author(s). FAU - Yeravdekar, Rajiv AU - Yeravdekar R AD - Faculty of Medical & Health Sciences, Symbiosis International (Deemed University), Gram Lavale, Pune, Maharashtra, India. FAU - Chandak, Alaka AU - Chandak A AD - Symbiosis Institute of Health Sciences (SIHS), Symbiosis International (Deemed University), Pune, Maharashtra, India. dralaka@sihs.edu.in. AD - , Pune, India. dralaka@sihs.edu.in. LA - eng PT - Journal Article PT - Observational Study DEP - 20260623 PL - Switzerland TA - J Epidemiol Glob Health JT - Journal of epidemiology and global health JID - 101592084 SB - IM MH - Humans MH - Male MH - Female MH - *Students/statistics & numerical data MH - Universities MH - Retrospective Studies MH - Adult MH - Young Adult MH - India/epidemiology MH - *Anemia/epidemiology MH - Mass Screening MH - Adolescent MH - Body Mass Index MH - *Hypertension/epidemiology MH - *Cardiometabolic Risk Factors MH - Blood Pressure PMC - PMC13575005 OTO - NOTNLM OT - Anemia OT - Cardiometabolic risks OT - Electronic medical records OT - Health promoting universities OT - High blood pressure OT - Student health OT - Universities COIS- Declarations. Ethical approval: Ethics approval was obtained from the Institutional Ethics Committee of Symbiosis International (Deemed University), Approval No. SIU/IEC/1137. Consent to participate: The requirement for individual informed consent was waived by the Institutional Ethics Committee because the study used anonymized retrospective EHR data. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 12:36 MHDA- 2026/09/15 05:36 PMCR- 2026/06/23 CRDT- 2026/06/23 11:05 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/09/15 05:36 [medline] PHST- 2026/06/23 12:36 [pubmed] PHST- 2026/06/23 11:05 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1007/s44197-026-00597-w [pii] AID - 597 [pii] AID - 10.1007/s44197-026-00597-w [doi] PST - epublish SO - J Epidemiol Glob Health. 2026 Jun 23;16(1):111. doi: 10.1007/s44197-026-00597-w. PMID- 42334123 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1098-240X (Electronic) IS - 0160-6891 (Print) IS - 0160-6891 (Linking) VI - 49 IP - 5 DP - 2026 Oct TI - The Psychometric Properties of the Caregiver Feeding Style Questionnaire: A Cross-Cultural Validation in Spanish Parents. PG - 657-667 LID - 10.1002/nur.70093 [doi] AB - Parental feeding styles are a key dimension of parent-child interactions during mealtimes and have a significant influence on children's development. Through their impact on children's eating behaviours, these styles are a key focus for enhancing the well-being of both the child and the family as a whole. This study aimed to cross-culturally adapt, translate, and validate the Caregiver Feeding Style Questionnaire (CFSQ) in a Spanish sample. This is a cross-sectional study that conducted in a Spanish cohort. Data were collected at four time points, from hospital discharge until the children were aged 7-10 years old. As part of the CFSQ validation study, the original English version underwent linguistic validation, which included 20 cognitive interviews with parents. Confirmatory factor analysis (CFA) of the CFSQ was then conducted using the cohort sample. A total of 194 Spanish parents of children aged 7-10 years old completed the CFSQ. Some items were slightly modified to improve cultural adaptation. Two CFA models were tested: a bidimensional and a unidimensional model. Both showed acceptable fit indices: bidimensional model -X(2) = 3,385.28 (df = 171; p < 0.001), CFI = 0.902, TLI = 0.889, RMSEA = 0.104 (90%CI 0.094-0.115), and SRMR = 0.09; unidimensional model- X(2) = 2,714.22 (df = 78; p < 0.001), CFI = 0.880, TLI = 0.900, RMSEA = 0.145 (90%CI 0.130-0.161), and SRMR = 0.094-. Both models demonstrated adequate internal consistency. In conclusion, the Spanish version of the CFSQ showed adequate structural validity and psychometric properties. While both models were acceptable, the shorter unidimensional version is preferable due to its parsimony and performance. CI - (c) 2026 The Author(s). Research in Nursing & Health published by Wiley Periodicals LLC. FAU - Lozano-Casanova, Mar AU - Lozano-Casanova M AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Escribano, Silvia AU - Escribano S AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Oliver-Roig, Antonio AU - Oliver-Roig A AUID- ORCID: 0000-0001-9171-820X AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Gutierrez-Hervas, Ana AU - Gutierrez-Hervas A AUID- ORCID: 0000-0003-3210-7200 AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Richart-Martinez, Miguel AU - Richart-Martinez M AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Sospedra, Isabel AU - Sospedra I AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. LA - eng GR - PI14/01549/Instituto de Salud Carlos III/ GR - GRE21-08B/Universidad de Alicante/ PT - Journal Article PT - Validation Study DEP - 20260623 PL - United States TA - Res Nurs Health JT - Research in nursing & health JID - 7806136 SB - IM MH - Humans MH - Child MH - Psychometrics MH - Spain MH - Surveys and Questionnaires/standards MH - Female MH - Cross-Sectional Studies MH - Male MH - Cross-Cultural Comparison MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - *Parents/psychology MH - *Parent-Child Relations MH - Adult MH - *Caregivers/psychology PMC - PMC13539630 COIS- The authors declare no conflicts of interest. EDAT- 2026/06/23 12:34 MHDA- 2026/09/03 17:36 PMCR- 2026/09/03 CRDT- 2026/06/23 08:32 PHST- 2026/05/18 00:00 [revised] PHST- 2025/11/23 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/03 17:36 [medline] PHST- 2026/06/23 12:34 [pubmed] PHST- 2026/06/23 08:32 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - NUR70093 [pii] AID - 10.1002/nur.70093 [doi] PST - ppublish SO - Res Nurs Health. 2026 Oct;49(5):657-667. doi: 10.1002/nur.70093. Epub 2026 Jun 23. PMID- 42334025 OWN - NLM STAT- Publisher LR - 20260623 IS - 1600-0528 (Electronic) IS - 0301-5661 (Linking) DP - 2026 Jun 23 TI - Implementation of Child Healthy Weight Guidelines in the Dental Setting: A Pilot Study. LID - 10.1111/cdoe.70088 [doi] AB - BACKGROUND: There has been an increasing prevalence of childhood overweight and obesity worldwide and locally, with a quarter of Australian children now considered overweight. To address this, the New South Wales government in Australia released guidelines calling for all public dental services to identify children above a healthy weight and refer them to appropriate services. This study was part of a larger study that aimed to codesign and pilot implementation strategies to facilitate the translation of these guidelines into dental staff's practice. METHODS: A pre-post-test design was used to evaluate the strategies across two health districts in NSW. Strategies were codesigned by dental staff and parents of patients and included linguistically appropriate resources; discharge summaries from referral pathways; refresher training; involvement of dental assistants; templates for longitudinal BMI measures and growth assessment flyers for patients. A validated questionnaire measuring intention to engage in the guidelines and self-reported practice was distributed to interested staff before and after the delivery of strategies (2019-2022). Data describing dental staff's' actual practices over this time were also retrieved from patient information management systems. Descriptive and inferential statistics were used to assess the study outcomes and any differences across districts (n = 16). RESULTS: There was no improvement in behavioural determinants of providing a growth assessment as indicated by the overall intention to engage in Children's Healthy Weight guideline (iCHEW) scale scores, however attitude scores had the largest observed improvement (from 30.1 to 35.2) and this was most pronounced in District 2 (27.2-34.3). A significant improvement in adherence to children's healthy weight guidelines was also seen in District 2 (increase of 20.54%, 95% CI 14.09-27.44). In District 1, children had 1.5 times the odds of receiving a growth assessment if they were treated by a dental officer (OR = 1.54; 95% CI 1.00-1.72). Conversely, children in District 2 had significantly lower odds of receiving a growth assessment if they were treated by a dental officer (OR = 0.203; 95% CI 0.12-0.35) or if they were treated at a satellite clinic (OR = 0.572; 95% CI 0.45-0.73). CONCLUSION: Dental staff can play a key role in addressing childhood overweight and obesity, although this can be challenging. The findings suggested some improvements in behavioural determinants and self-reported behaviours following supportive strategies. Further research to confirm these findings using larger sample sizes is recommended. CI - (c) 2026 The Author(s). Community Dentistry and Oral Epidemiology published by John Wiley & Sons Ltd. FAU - Villarosa, Amy R AU - Villarosa AR AUID- ORCID: 0000-0003-3198-472X AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. FAU - Maneze, Della AU - Maneze D AUID- ORCID: 0000-0001-6475-8804 AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia. FAU - Ramjan, Lucie AU - Ramjan L AUID- ORCID: 0000-0001-7815-3005 AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia. FAU - Patterson-Norrie, Tiffany AU - Patterson-Norrie T AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - School of Medicine, Faculty of Health, Western Sydney University, Sydney, New South Wales, Australia. FAU - Srinivas, Ravi AU - Srinivas R AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - Oral Health Services, South Western Sydney Local Health District, Sydney, New South Wales, Australia. AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Yaacoub, Albert AU - Yaacoub A AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Oral Health Services, Nepean Blue Mountains Local Health District, Sydney, New South Wales, Australia. FAU - Kumar, Tanya AU - Kumar T AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Oral Health Services, Nepean Blue Mountains Local Health District, Sydney, New South Wales, Australia. FAU - George, Ajesh AU - George A AUID- ORCID: 0000-0002-6795-2546 AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia. AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. LA - eng GR - GNT1168119/National Health and Medical Research Council/ GR - GNT1168119/Western Sydney University/ PT - Journal Article DEP - 20260623 PL - Denmark TA - Community Dent Oral Epidemiol JT - Community dentistry and oral epidemiology JID - 0410263 SB - IM OTO - NOTNLM OT - dental staff OT - dentist OT - guidelines OT - implementation OT - oral health EDAT- 2026/06/23 12:35 MHDA- 2026/06/23 12:35 CRDT- 2026/06/23 08:13 PHST- 2026/04/07 00:00 [revised] PHST- 2024/11/05 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/23 12:35 [medline] PHST- 2026/06/23 12:35 [pubmed] PHST- 2026/06/23 08:13 [entrez] AID - 10.1111/cdoe.70088 [doi] PST - aheadofprint SO - Community Dent Oral Epidemiol. 2026 Jun 23. doi: 10.1111/cdoe.70088. PMID- 42333937 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260803 IS - 1758-0854 (Electronic) IS - 1758-0854 (Linking) VI - 18 IP - 3 DP - 2026 Jun TI - Developing a mix-method protocol to assess green space quality for multiage health-related activities. PG - e70176 LID - 10.1111/aphw.70176 [doi] AB - The development of an urban green space (UGS) quality assessment protocol addressing the health-related activities of older adults and children represents a sustainable approach to promoting health and well-being. Although most protocols have been developed for physical activity, few have considered other categories of health-related activities that encompass multiple age groups. This study develops a mixed-method green space for multiage health-related activities (GMHA) protocol to assess UGS quality for older adults, children, and the general population across different health-related activities, including physical activity and social interaction. Five conventional domains of facility, amenity, aesthetics, maintenance, safety, and incivilities audited by systematic observation are integrated with the geospatial domains of natural environments and spatial configuration, supported by unmanned aerial vehicle and space syntax techniques. Seventy UGS samples were tested for interrater reliability via intraclass correlation coefficients. The relative importance of each UGS domain in the protocol was further examined using a spatial autoregressive (SAR) model. Content validity is substantiated by scholarship. Preliminary tests verified quantitative reliability and concurrent validity. SAR results revealed varying associations between UGS domains and multiage health-related activities, highlighting the significance of the environment-individual-activity interaction. GMHA can facilitate targeting UGS quality enhancement across broader contexts and populations to benefit health and well-being. CI - (c) 2026 International Association of Applied Psychology. FAU - Chen, Shuolei AU - Chen S AUID- ORCID: 0000-0002-4891-4077 AD - College of Landscape Architecture, Nanjing Forestry University, Nanjing, China. FAU - Wang, Chongxiao AU - Wang C AUID- ORCID: 0009-0005-8361-8969 AD - College of Environment + Design, University of Georgia, Athens, Georgia, USA. FAU - Cheng, Shi AU - Cheng S AD - College of Architecture, Southeast University, Nanjing, China. FAU - Yang, Zhuoheng AU - Yang Z AD - College of Design and Engineering, National University of Singapore, Singapore, Singapore. FAU - Wang, Yan AU - Wang Y AD - College of Landscape Architecture, Nanjing Forestry University, Nanjing, China. LA - eng GR - 52308066/National Natural Science Foundation of China/ GR - BK20230401/Natural Science Foundation of Jiangsu Province/ GR - 2023M741720/China Postdoctoral Science Foundation/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Appl Psychol Health Well Being JT - Applied psychology. Health and well-being JID - 101502957 SB - IM MH - Humans MH - Reproducibility of Results MH - Aged MH - *Environment Design/standards MH - *Exercise MH - Female MH - Male MH - *Social Interaction OTO - NOTNLM OT - children OT - elder OT - geospatial OT - health and well-beings OT - physical activity OT - social interaction OT - urban green space EDAT- 2026/06/23 12:34 MHDA- 2026/06/23 12:35 CRDT- 2026/06/23 07:54 PHST- 2025/07/07 00:00 [received] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/23 12:35 [medline] PHST- 2026/06/23 12:34 [pubmed] PHST- 2026/06/23 07:54 [entrez] AID - 10.1111/aphw.70176 [doi] PST - ppublish SO - Appl Psychol Health Well Being. 2026 Jun;18(3):e70176. doi: 10.1111/aphw.70176. PMID- 42333538 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261007 IS - 1839-2628 (Electronic) IS - 1832-4274 (Linking) VI - 29 IP - 4 DP - 2026 Aug TI - The Population-Based Hungarian Twin Registry: Current Register Data, Researches and Linkages. PG - 378-384 LID - 10.1017/thg.2026.10075 [doi] AB - The Hungarian Twin Registry (HTR) has operated as a population-based registry since 2021, following its establishment at Semmelweis University in Budapest. In recent years, the HTR infrastructure has been substantially expanded, including blood storage facilities, information technology systems, a phone bank and voicemail system, and administrative resources. Adult twins (aged >/=18 years) and relatives (parents, foster parents, or caregivers) of twins under 18 years of age can register via the registry's website or by voicemail following a nationwide identification and notification process. The registration questionnaire consists of eight sections covering sociodemographic and anthropometric characteristics, smoking habits, and medical history, including diseases, surgeries, and therapies. By December 20, 2025, a total of 12,676 twin individuals and their parents or guardians had registered, including 7244 adult twins and 5432 parents or guardians of minors. Based on self-reported data, 44.1% of registered adult twins were monozygotic (MZ) and 55.9% dizygotic (DZ), while among registered children 23.5% were MZ and 76.5% DZ. Of the registered adult twins, 68.4% were female. The HTR offers substantial potential for linkage with national health databases, enabling enrichment of phenotypic and outcome data without additional participant burden. In particular, linkage with the Hungarian National Cancer Registry and other health-related databases is feasible under appropriate ethical approval and data protection procedures and may support long-term follow-up and disease-specific analyses. The article also summarizes current research projects conducted within the HTR, which has become the largest population-based twin registry in Central and Eastern Europe based on the number of registrations. FAU - Tarnoki, David Laszlo AU - Tarnoki DL AUID- ORCID: 0000-0002-7001-7647 AD - Medical Imaging Centre, Semmelweis University, Hungary. ROR: https://ror.org/01g9ty582 AD - National Tumor Biology Laboratory, National Institute of Oncology, Hungary. AD - Hungarian Twin Registry Foundation, Hungary. FAU - Piroska, Marton AU - Piroska M AD - Medical Imaging Centre, Semmelweis University, Hungary. ROR: https://ror.org/01g9ty582 AD - Hungarian Twin Registry Foundation, Hungary. FAU - Melicher, Dora AU - Melicher D AD - Hungarian Twin Registry Foundation, Hungary. AD - Department of Emergency Medicine, Semmelweis University, Hungary. FAU - Metneki, Julia AU - Metneki J AD - Hungarian Twin Registry Foundation, Hungary. FAU - Littvay, Levente AU - Littvay L AD - Hungarian Twin Registry Foundation, Hungary. AD - HUN-REN Centre for Social Sciences, Hungarian Research Network, Hungary. FAU - Tarnoki, Adam Domonkos Domonkos AU - Tarnoki ADD AUID- ORCID: 0000-0001-5909-3780 AD - Medical Imaging Centre, Semmelweis University, Hungary. ROR: https://ror.org/01g9ty582 AD - Hungarian Twin Registry Foundation, Hungary. AD - Oncologic Imaging and Invasive Diagnostic Centre, National Tumor Biology Laboratory, Orszagos Onkologiai Intezet, Hungary. ROR: https://ror.org/02kjgsq44 LA - eng PT - Journal Article PT - Twin Study DEP - 20260623 PL - England TA - Twin Res Hum Genet JT - Twin research and human genetics : the official journal of the International Society for Twin Studies JID - 101244624 SB - IM MH - Humans MH - *Registries/statistics & numerical data MH - Female MH - Hungary/epidemiology MH - *Twins, Dizygotic/genetics/statistics & numerical data MH - Male MH - *Twins, Monozygotic/genetics/statistics & numerical data MH - Adult MH - *Diseases in Twins/epidemiology/genetics MH - Middle Aged MH - Adolescent MH - Child MH - Aged MH - Young Adult MH - Child, Preschool OTO - NOTNLM OT - Discordant twin studies OT - Hungarian Twin Registry OT - Population-based registry EDAT- 2026/06/23 11:34 MHDA- 2026/10/06 11:31 CRDT- 2026/06/23 05:53 PHST- 2026/10/06 11:31 [medline] PHST- 2026/06/23 11:34 [pubmed] PHST- 2026/06/23 05:53 [entrez] AID - S1832427426100759 [pii] AID - 10.1017/thg.2026.10075 [doi] PST - ppublish SO - Twin Res Hum Genet. 2026 Aug;29(4):378-384. doi: 10.1017/thg.2026.10075. Epub 2026 Jun 23. PMID- 42333529 OWN - NLM STAT- Publisher LR - 20260623 IS - 1536-3724 (Electronic) IS - 1050-642X (Linking) DP - 2026 Jun 24 TI - The Effect of Performance Training on Sideline Concussion Assessments in Adolescent Athletes: A Pilot Investigation. LID - 10.1097/JSM.0000000000001493 [doi] AB - OBJECTIVE: The vestibular ocular motor screen (VOMS) and the Sport Concussion Assessment Tool 6 (SCAT6) are point-of-care concussion assessments administered immediately or soon after sports participation or exercise. To retain validity and accuracy, the results of these tests should not be affected by sporting activity. We assessed the effect on the mVOMS (modified VOMS) and SCAT6 immediately and 20 minutes after performance training in high school athletes. DESIGN: Nonrandomized pilot experimental study. SETTING: High School, Buffalo, NY. PARTICIPANTS: Nonconcussed athletes (n = 23, 39% male, 15.5 +/- 1.0 years). INDEPENDENT VARIABLE: Performance Training (pretraining, post-training, 20 minutes post-training). MAIN OUTCOME MEASURES: mVOMS and SCAT6 scores (standardized assessment of concussion, modified balance error scoring system, timed tandem gait [TTG], dual task tandem gait [DTTG]). RESULTS: TTG (P = 0.005) and DTTG (P = 0.045) improved significantly from prepractice to immediate postpractice and from pretraining to 20 minutes post-training (TTG [P = 0.002], DTTG [P = 0.006]). There were no other differences in SCAT6 or mVOMS scores among the 3 time points. CONCLUSIONS: SCAT6 and mVOMS performance was not adversely affected by moderately intense exercise training in high school athletes. TTG and DTTG performance improved after exercise, consistent with the learning effect. Further research should be conducted across other populations to increase generalizability. Clinicians should be confident that fatigue and exertion from acute performance training activities are not likely to affect the performance of these widely used sideline concussion assessment tools. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Chizuk, Haley AU - Chizuk H AUID- ORCID: 0000-0003-2113-0536 AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Marshall, Kendall AU - Marshall K AD - Sports Medicine Department, Excelsior Orthopaedics, Amherst, New York. FAU - Yunke, Alexander AU - Yunke A AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Kaiser, Ethan AU - Kaiser E AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Thavisin, Tiffany AU - Thavisin T AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. FAU - Adebiyi, Halleluyah AU - Adebiyi H AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Sardinia, William AU - Sardinia W AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Tousignant, Joseph R AU - Tousignant JR AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Leddy, John AU - Leddy J AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Haider, Mohammad N AU - Haider MN AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Jain, Rajiv K AU - Jain RK AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. LA - eng PT - Journal Article DEP - 20260624 PL - United States TA - Clin J Sport Med JT - Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine JID - 9103300 SB - IM OTO - NOTNLM OT - concussion OT - concussion assessment OT - exercise OT - pediatrics OT - point-of-care assessments COIS- The authors report no conflicts of interest. EDAT- 2026/06/23 11:34 MHDA- 2026/06/23 11:34 CRDT- 2026/06/23 05:52 PHST- 2025/10/27 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/23 11:34 [medline] PHST- 2026/06/23 11:34 [pubmed] PHST- 2026/06/23 05:52 [entrez] AID - 00042752-990000000-00435 [pii] AID - 10.1097/JSM.0000000000001493 [doi] PST - aheadofprint SO - Clin J Sport Med. 2026 Jun 24. doi: 10.1097/JSM.0000000000001493. PMID- 42332988 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260910 IS - 1651-2227 (Electronic) IS - 0803-5253 (Print) IS - 0803-5253 (Linking) VI - 115 IP - 10 DP - 2026 Oct TI - Fasting Biomarkers and Glycated Haemoglobin Identify Children With Excess Weight at Risk of Dysglycaemia and Guide Oral Glucose Tolerance Testing. PG - 2305-2314 LID - 10.1111/apa.70657 [doi] AB - AIM: Childhood obesity has been strongly associated with insulin resistance and dysglycaemia. We aimed to evaluate fasting biomarkers and glycated haemoglobin (HbA1c) for identifying children at risk and guiding the need for oral glucose tolerance testing (OGTT). METHODS: This single-centre study included 475 consecutive children aged 5-18 years with excess weight who underwent OGTT. Insulin resistance and dysglycaemia were defined based on OGTT-derived indices. Fasting glucose (FG), fasting insulin (FI), homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of beta-cell function (HOMA-beta), and HbA1c were evaluated. Receiver operating characteristic (ROC) analysis was used to determine optimal cut-offs for predicting dysglycaemia. RESULTS: The cohort comprised 281 girls (59.2%) and 194 boys, with a median age of 13.8 years. Insulin resistance was present in 81.5% (387/475) and dysglycaemia in 18.9% (90/475). FG above the 90th percentile, FI and HOMA-IR above the 97.5th percentile, and HbA1c >/= 39 mmol/mol (5.7%) were significantly associated with dysglycaemia (p < 0.05). ROC analysis for the entire cohort identified FG 5.27 mmol/L, HbA1c 39 mmol/mol, and HOMA-IR 4.88 as significant cut-offs (all p < 0.001). CONCLUSION: Fasting biomarkers and HbA1c identified children with excess weight at risk of dysglycaemia, providing practical thresholds to guide the need for OGTT. CI - (c) 2026 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. FAU - Sarikaya, Emre AU - Sarikaya E AD - Department of Paediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkiye. FAU - Kilci, Fatih AU - Kilci F AUID- ORCID: 0000-0003-4040-7908 AD - Department of Paediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkiye. FAU - Murat, Nurhan Ozcan AU - Murat NO AD - Department of Paediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkiye. LA - eng PT - Journal Article DEP - 20260622 PL - Norway TA - Acta Paediatr JT - Acta paediatrica (Oslo, Norway : 1992) JID - 9205968 RN - 0 (Biomarkers) RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Biomarkers/blood MH - Glucose Tolerance Test MH - Child MH - *Glycated Hemoglobin/analysis/metabolism MH - Male MH - Fasting/blood MH - Child, Preschool MH - Adolescent MH - Insulin Resistance MH - Blood Glucose/analysis MH - *Pediatric Obesity/blood/complications PMC - PMC13552578 OTO - NOTNLM OT - childhood obesity OT - fasting glucose OT - fasting insulin OT - homeostatic model assessment of insulin resistance OT - oral glucose tolerance test COIS- The authors declare no conflicts of interest. EDAT- 2026/06/23 11:37 MHDA- 2026/09/08 17:36 PMCR- 2026/09/08 CRDT- 2026/06/23 03:13 PHST- 2026/04/09 00:00 [revised] PHST- 2026/01/15 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/09/08 17:36 [medline] PHST- 2026/06/23 11:37 [pubmed] PHST- 2026/06/23 03:13 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - APA70657 [pii] AID - 10.1111/apa.70657 [doi] PST - ppublish SO - Acta Paediatr. 2026 Oct;115(10):2305-2314. doi: 10.1111/apa.70657. Epub 2026 Jun 22. PMID- 42332830 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260922 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Jun 22 TI - Developing new energy intake reference values for the Saudi population. LID - 10.1186/s40795-026-01392-3 [doi] LID - 120 AB - BACKGROUND: This study updates the average requirement for energy intake (AR-EI) for the Saudi population, thereby addressing outdated references. Previous estimates relied on generalized equations and non-specific data, which often led to overestimations. This study aimed to establish new AR-EI values for Saudi population. METHODS: The study methodology combined two complementary approaches to estimate energy requirements. For adults, a factorial approach was used, incorporating physical activity levels observed in the Saudi population along with reference values for body weight and height, applied in published Saudi predictive equations for Basal Metabolic Rate (BMR). For infants, children, and adolescents (0-17 years), the study used Total Energy Expenditure (TEE) predictive equations derived from multi-country doubly labeled water (DLW) studies. RESULTS: After calculating the requirements across different age groups and sexes, the value representing the average that meets the needs of 50% of the population was identified and adopted as the AR-EI. The AR-EI values ranged from 393 kcal/day during the first six months to 778 kcal/day by 12 months for male infants, while female infants required 364-748 kcal/day. Among children and adolescents, AR-EI values ranged from 912 to 3147 kcal/day. For adults, the AR-EI was estimated at 2207 kcal/day for men and 1708 kcal/day for women under current activity levels. With increased physical activity, these requirements rose to 3153 kcal/day for men and 2440 kcal/day for women. CONCLUSIONS: This study identified significant overestimations in previous references owing to the reliance on generalized equations and outdated data. By incorporating Saudi-specific data, these findings provide accurate and practical benchmarks for energy intake. These results serve as a foundation for evidence-based nutritional guidelines, promoting public health and reducing the incidence of diet-related diseases. CI - (c) 2026. The Author(s). FAU - Alhumaidan, Omar AU - Alhumaidan O AD - Saudi Food and Drug Authority (SFDA), Riyadh, Kingdom of Saudi Arabia. oahumaidan@sfda.gov.sa. AD - Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia. oahumaidan@sfda.gov.sa. FAU - Almajwal, Ali AU - Almajwal A AD - Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia. FAU - Alsaif, Mohammed AU - Alsaif M AD - Saudi Food and Drug Authority (SFDA), Riyadh, Kingdom of Saudi Arabia. AD - Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia. LA - eng PT - Journal Article DEP - 20260622 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13296159 OTO - NOTNLM OT - Body Weight OT - Caloric OT - Energy intake OT - Nutrition OT - Reference Value COIS- Declarations: "The views expressed in this paper are those of the author(s) and do not necessarily reflect those of the SFDA or its stakeholders. Guaranteeing the accuracy and validity of the data is the sole responsibility of the research team." Ethics approval and consent to participate: This study was conducted as a secondary analysis of previously published data on anthropometric reference measurements and reported metabolic rates. No primary data were collected from human participants. The study protocol was reviewed by the Regulatory Research Committee of the Saudi Food and Drug Authority (Reference No. FD-2025-003). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:35 MHDA- 2026/06/23 11:36 PMCR- 2026/06/22 CRDT- 2026/06/23 01:17 PHST- 2025/01/06 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/06/23 11:36 [medline] PHST- 2026/06/23 11:35 [pubmed] PHST- 2026/06/23 01:17 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s40795-026-01392-3 [pii] AID - 1392 [pii] AID - 10.1186/s40795-026-01392-3 [doi] PST - epublish SO - BMC Nutr. 2026 Jun 22;12(1):120. doi: 10.1186/s40795-026-01392-3. PMID- 42332742 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260909 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 22 TI - From systemic immune dysregulation to oral disease: evidence linking food allergies and oral manifestations- a systematic review. LID - 10.1186/s12903-026-08964-6 [doi] LID - 1658 AB - BACKGROUND: Food allergy is a common immune-mediated condition in children and is increasingly recognized to affect the oral cavity. Oral manifestations may represent early signs of allergic sensitization and can influence oral health, nutrition, and quality of life. This systematic review aimed to synthesize the available evidence on oral manifestations associated with food allergies in pediatric populations. METHODS: A systematic literature search was conducted in PubMed Medline, Scopus, Web of Science, and the Cochrane Library for studies published up to December 2025. Eligibility criteria included observational and clinical studies published in English that reported oral or dental manifestations in children and adolescents aged 0-18 years with diagnosed IgE-mediated or non-IgE-mediated food allergy. Study selection, data extraction, and risk of bias assessment were performed independently by two reviewers in accordance with PRISMA 2020 guidelines. The quality of included studies was assessed using the Newcastle-Ottawa Scale. RESULTS: Twelve pediatric studies met the inclusion criteria. The most frequently reported oral manifestations were itching and tingling of the lips, tongue, palate, and oral mucosa following ingestion of specific foods, particularly fruits and nuts. Mild labial and oral mucosal swelling were also commonly described. These symptoms were consistent with oral allergy syndrome and were most frequently observed in school-aged children with pollen sensitization. Oral manifestations occurred rapidly after food exposure and were reproducible across different populations and geographic regions. CONCLUSION: Oral manifestations are common features of pediatric food allergy and frequently represent localized IgE-mediated reactions. Recognition of these symptoms is important for early identification of food allergy and appropriate referral. Increased awareness among pediatric dentists may contribute to improved detection and multidisciplinary management of affected children. CI - (c) 2026. The Author(s). FAU - Sharma, Pratyasha AU - Sharma P AUID- ORCID: 0009-0001-0513-648X AD - Department of Pediatric & Preventive Dentistry, NITTE (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka, 575018, India. FAU - Bhandary, Srikala AU - Bhandary S AUID- ORCID: 0000-0001-7682-0345 AD - Department of Pediatric & Preventive Dentistry, NITTE (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka, 575018, India. docsrikala@gmail.com. FAU - Das, Sayan AU - Das S AUID- ORCID: 0009-0005-9473-7760 AD - Department of Pediatric & Preventive Dentistry, NITTE (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka, 575018, India. FAU - Taha, Syed AU - Taha S AUID- ORCID: 0009-0006-5109-7078 AD - Department of Pediatric & Preventive Dentistry, NITTE (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka, 575018, India. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260622 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Food Hypersensitivity/immunology/complications MH - Child MH - *Mouth Diseases/immunology/etiology MH - Adolescent MH - Child, Preschool MH - Infant MH - Oral Allergy Syndrome PMC - PMC13540877 OTO - NOTNLM OT - Children OT - Food allergy OT - Oral allergy syndrome OT - Oral manifestations OT - Pediatric dentistry COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:34 MHDA- 2026/09/03 05:36 PMCR- 2026/06/22 CRDT- 2026/06/23 01:12 PHST- 2025/12/29 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/03 05:36 [medline] PHST- 2026/06/23 11:34 [pubmed] PHST- 2026/06/23 01:12 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12903-026-08964-6 [pii] AID - 8964 [pii] AID - 10.1186/s12903-026-08964-6 [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 22;26(1):1658. doi: 10.1186/s12903-026-08964-6. PMID- 42332731 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1477-7827 (Electronic) IS - 1477-7827 (Linking) VI - 24 IP - 1 DP - 2026 Jun 22 TI - Association of celiac disease with menstrual and hormonal disturbances: a systematic review and meta-analysis. LID - 10.1186/s12958-026-01572-7 [doi] LID - 82 AB - BACKGROUND: Disturbances in the female reproductive system are known extraintestinal manifestations of celiac disease (CD). However, the reliability of the existing literature is limited by small study populations and heterogeneous study designs. This study is the first systematic review and meta-analysis to synthesize all available evidence and provide a comprehensive evaluation of the association between CD and female menstrual and hormonal parameters. METHODS: A systematic literature search was conducted in PubMed, Scopus, and Cochrane Central databases using keywords related to CD, menstrual characteristics, and hormonal markers. Studies published until August 2025 were included. RESULTS: Our analysis demonstrated a significantly higher mean age at menarche in girls with CD compared with controls [pooled mean difference (MD): 0.64 years, 95% confidence interval (CI): 0.32 to 0.95, p = 0.0007), as well as an increased risk of abnormal uterine bleeding [pooled odds ratio (OR): 2.11, 95% CI: 1.23 to 3.63, p < 0.05] and amenorrhea (pooled OR: 4.03, 95% CI: 1.11 to 14.65, p = 0.0394). Menopausal age was not found to be earlier in women with CD (pooled MD: -1.31 years, 95% CI: -3.02 to 0.40, p = 0.1053). Adherence to a gluten-free diet was not associated with age at menarche when adherent and non-adherent patients were compared (pooled MD: 0.56 years, 95% CI: -0.72 to 1.83, p = 0.260). Furthermore, none of the evaluated biochemical hormonal markers (FSH, LH, estradiol, prolactin, and AMH) differed significantly between women with CD and controls. CONCLUSION: This systematic review and meta-analysis reinforces the existing evidence that CD may adversely affect several aspects of menstrual health in women without significantly impacting biochemical hormonal markers. CI - (c) 2026. The Author(s). FAU - Delis, Michail AU - Delis M AD - 1 st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, Thessaloniki, Greece. mdelisa@auth.gr. FAU - Emmanouilidou-Fotoulaki, Elpida AU - Emmanouilidou-Fotoulaki E AD - 1 st Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, "Hippokration" General Hospital, Thessaloniki, Greece. FAU - Iordanidou, Eirini AU - Iordanidou E AD - 1 st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, Thessaloniki, Greece. FAU - Tsimperidis, Achilleas G AU - Tsimperidis AG AD - Gastroenterology and Hepatology Division, 2nd Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, "Hippokration" General Hospital, Thessaloniki, Greece. FAU - Giouleme, Olga AU - Giouleme O AD - Gastroenterology and Hepatology Division, 2nd Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, "Hippokration" General Hospital, Thessaloniki, Greece. FAU - Goulis, Dimitrios G AU - Goulis DG AD - 1 st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, Thessaloniki, Greece. FAU - Theodoridis, Theodoros AU - Theodoridis T AD - 1 st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, Thessaloniki, Greece. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260622 PL - England TA - Reprod Biol Endocrinol JT - Reproductive biology and endocrinology : RB&E JID - 101153627 SB - IM MH - Humans MH - *Celiac Disease/complications/physiopathology MH - Female MH - *Menstruation Disturbances/etiology/epidemiology MH - Menarche/physiology PMC - PMC13555964 OTO - NOTNLM OT - Celiac disease OT - Hormonal OT - Menarche OT - Menopause OT - Menstrual OT - Ovarian COIS- Declarations. Ethics approval and consent to participate: Not applicable. This study is a systematic review and meta-analysis of previously published studies and did not involve the collection of new data from human participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:34 MHDA- 2026/09/09 07:07 PMCR- 2026/06/22 CRDT- 2026/06/23 01:12 PHST- 2026/02/17 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/23 11:34 [pubmed] PHST- 2026/06/23 01:12 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12958-026-01572-7 [pii] AID - 1572 [pii] AID - 10.1186/s12958-026-01572-7 [doi] PST - epublish SO - Reprod Biol Endocrinol. 2026 Jun 22;24(1):82. doi: 10.1186/s12958-026-01572-7. PMID- 42332665 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260909 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Evaluation of the application of three dimensional-printed occlusal splint in conservative treatment of condylar fractures. LID - 10.1186/s12903-026-08927-x [doi] LID - 1505 AB - BACKGROUND: Conservative treatment of condylar fractures requires the use of occlusal splints. However, limited mouth opening, pain, and tooth damage often prevent timely impression taking, which hinders the fabrication of the occlusal splints. Therefore, there is an urgent need for a convenient and new method. The objective of this study is to evaluate the clinical outcomes and feasibility of innovative 3D-printed occlusal splints for the conservative treatment of condylar fractures. METHODS: This was a retrospective observational case series study aimed to investigate the clinical outcomes of 3D-printed occlusal splints in the conservative treatment of condylar fractures. The patients were divided into pediatric, adolescent, and adult groups according to age. The 3D-printed occlusal splint was secured to the maxilla for 2 months. Patients were instructed to perform mouth-opening exercises daily. Mouth opening was recorded before treatment and at the 3-month follow-up. Data were statistically analyzed. RESULTS: After 3 months of follow-up, no patients reported persistent pain, with mouth-opening and masticatory functions recovered. The postoperative mouth opening of all three groups was significantly greater compared with preoperative values, and the difference was statistically significant (P < 0.05). Regarding deviation of the mandible during mouth opening, the adolescent group showed significant improvement postoperatively (P < 0.05), whereas no statistically significant difference was observed in the pediatric group and the adult group. CONCLUSION: The use of a 3D-printed occlusal splint combined with mouth-opening exercises is a feasible approach for the conservative treatment of condylar fractures. CI - (c) 2026. The Author(s). FAU - Zhang, Difei AU - Zhang D AD - State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People's Republic of China. FAU - Lv, Kun AU - Lv K AD - State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People's Republic of China. lvkun@whu.edu.cn. AD - Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, People's Republic of China. lvkun@whu.edu.cn. LA - eng PT - Journal Article PT - Observational Study DEP - 20260623 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Occlusal Splints MH - *Mandibular Condyle/injuries MH - *Printing, Three-Dimensional MH - Adolescent MH - *Mandibular Fractures/therapy MH - Retrospective Studies MH - Female MH - Adult MH - Child MH - Male MH - Young Adult MH - Treatment Outcome MH - *Conservative Treatment PMC - PMC13483849 OTO - NOTNLM OT - Condyle OT - Conservative Treatment OT - Fracture OT - Mandibular OT - Occlusal Splints OT - Three-Dimensional Printing COIS- Declarations. Ethics approval and consent to participate: We have read the Helsinki Declaration and have followed the guidelines in this investigation. A specific informed consent form was designed, and the study was approved by the Medical Ethics Committee of Wuhan University School of Stomatology(No. WDKQ2024C23; No. WDKQ2025C01). All participants in this study provided written informed consent prior to their involvement. Consent for publication: All presentations of case reports have consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:36 MHDA- 2026/08/19 14:49 PMCR- 2026/06/23 CRDT- 2026/06/23 01:08 PHST- 2025/11/30 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/08/19 14:49 [medline] PHST- 2026/06/23 11:36 [pubmed] PHST- 2026/06/23 01:08 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12903-026-08927-x [pii] AID - 8927 [pii] AID - 10.1186/s12903-026-08927-x [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 23;26(1):1505. doi: 10.1186/s12903-026-08927-x. PMID- 42332646 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260926 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Psychometric properties of the weight self-stigma questionnaire and weight bias internalization scale in postpartum women. LID - 10.1186/s12884-026-09528-w [doi] LID - 1050 AB - BACKGROUND: Weight stigma internalization among postpartum women may differ from other populations owing to childbirth, breastfeeding, and postnatal physical recovery. Two instruments to assess the concept of weight stigma internalization-the Weight Self-Stigma Questionnaire (WSSQ) and the Weight Bias Internalization Scale (WBIS)-have not been validated in postpartum women. This study aims to evaluate and compare the reliability, factor structure, and concurrent validity between the WBIS and WSSQ in Chinese postpartum women. METHODS: A total of 476 postpartum women (mean age 30.96 +/- 4.67 years) completed the WSSQ and WBIS, as well as other relevant measures regarding perceived weight stigma, psychological outcomes, and eating behaviors. Height and weight were used to calculate the body mass index (BMI). Statistical analyses were performed using internal consistency analysis, confirmatory factor analysis, and correlation analysis. RESULTS: Both the WSSQ and the WBIS were found to have excellent internal consistency. In addition, both were associated with postpartum BMI, perceived weight stigma, adverse psychological outcomes, and restrained and emotional eating behaviors. Differently, the two-factor structure of the WSSQ was supported among postpartum women, but the one-factor WBIS was not. CONCLUSION: The WSSQ is a reliable and valid measurement tool for assessing weight stigma internalization in postpartum women. The structure of WBIS requires further validation and modification in future research. CI - (c) 2026. The Author(s). FAU - Pan, Ting AU - Pan T AD - School of Nursing, Changsha Medical University, Changsha, Hunan, China. AD - Xiangya School of Nursing, Central South University, Changsha, Hunan, China. FAU - Peng, Jiayuan AU - Peng J AD - Xiangyin Campus of Xiangxing College, Hunan University of Chinese Medicine, Yueyang, Hunan, China. AD - Hunan Institute of Traffic Engineering, Hengyang, Hunan, China. FAU - Tan, Xiangmin AU - Tan X AD - School of rural health, Monash University, Melbourne, VIC, Australia. FAU - Sun, Mei AU - Sun M AUID- ORCID: 0000-0001-5341-0845 AD - School of Nursing, Changsha Medical University, Changsha, Hunan, China. smnjw2008@126.com. AD - Xiangya School of Nursing, Central South University, Changsha, Hunan, China. smnjw2008@126.com. LA - eng GR - 22-464/China Medical Board Open Competition Program/ GR - 2026RC9046/Hunan Province Science and Technology Innovation Project/ PT - Journal Article PT - Validation Study DEP - 20260623 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - *Postpartum Period/psychology MH - Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Social Stigma MH - Adult MH - Body Mass Index MH - *Self Concept MH - Factor Analysis, Statistical MH - *Body Weight MH - *Body Image/psychology MH - Emotional Eating MH - China PMC - PMC13602467 OTO - NOTNLM OT - Assessment OT - Postpartum women OT - Psychometric properties OT - Self-stigma OT - Weight bias OT - Weight stigma COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the School of Nursing, Central South University (Approval No. E2021108). All participants provided verbal and written informed consent before study participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:35 MHDA- 2026/09/24 05:36 PMCR- 2026/06/23 CRDT- 2026/06/23 01:07 PHST- 2024/08/23 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/24 05:36 [medline] PHST- 2026/06/23 11:35 [pubmed] PHST- 2026/06/23 01:07 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12884-026-09528-w [pii] AID - 9528 [pii] AID - 10.1186/s12884-026-09528-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 23;26(1):1050. doi: 10.1186/s12884-026-09528-w. PMID- 42332642 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260909 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 22 TI - Forensic dental age estimation in a Pakistani population: validation of Atlas methods and development of a population-specific reference model. LID - 10.1186/s12903-026-08994-0 [doi] LID - 1652 AB - BACKGROUND: Accurate age estimation is essential in forensic and clinical contexts, particularly where birth records are unavailable. Dental development assessed through radiographic calcification is considered a reliable indicator. However, atlas-based methods have demonstrated variable accuracy across populations. This study aimed to evaluate the accuracy and agreement of the Schour and Massler chart and the London Atlas, and to develop a population-specific dental development scheme for a Pakistani cohort. METHODS: A cross-sectional forensic validation study was conducted using 700 digital panoramic radiographs of individuals aged 4.0-17.9 years, stratified by age and sex. Dental age was estimated using both methods and compared with the chronological age. The analyses included paired t-tests, correlation, intraclass correlation coefficient, Bland-Altman analysis, and linear regression. The predictive performance was assessed using the mean absolute error and proportions within +/- 1 and +/- 2 years. RESULTS: Both methods demonstrated strong correlations (r > 0.90) and high ICCs (> 0.85). The London Atlas showed lower mean bias (~ 0.2-0.4 years), narrower limits of agreement (+/- 1.5-2.0 years), and higher predictive accuracy (overall R(2) = 0.997; sex-stratified subgroup range: R(2) = 0.92-0.95) than the Schour and Massler method (overall R(2) = 0.982; sex-stratified subgroup range: R(2) = 0.85-0.90). Accuracy within +/- 1 year was higher for the London Atlas (> 75%) compared with Schour and Massler (< 65%), while both exceeded 90% within +/- 2 years. Population-specific analyses revealed a delay in early dental development. CONCLUSIONS: The London Atlas demonstrated superior agreement and predictive performance; however, population-specific variations limit its universal applicability. The newly developed Pak Atlas provides a more accurate reference for forensic age estimation in the Pakistani population, with direct relevance to medico-legal age assessment. CI - (c) 2026. The Author(s). FAU - Faraz, Syed Abul AU - Faraz SA AD - Department of Oral Biology, Liaquat College of Medicine & Dentistry, Karachi, Pakistan. FAU - Ahmed, Imtiaz AU - Ahmed I AD - Department of Orthodontics, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan. FAU - Zaidi, Syed Jaffar Abbas AU - Zaidi SJA AUID- ORCID: 0000-0002-2564-7818 AD - Department of Oral Biology & Digital Learning Centre, Dow Dental College, Dow University of Health Sciences, Karachi, Sindh, 74200, Pakistan. jaffar.zaidi@duhs.edu.pk. LA - eng PT - Journal Article PT - Validation Study DEP - 20260622 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Radiography, Panoramic MH - Child, Preschool MH - Pakistan MH - Child MH - Female MH - Cross-Sectional Studies MH - Male MH - Adolescent MH - Reference Values MH - *Forensic Dentistry/methods MH - Tooth Calcification PMC - PMC13536816 OTO - NOTNLM OT - Adolescent OT - Age determination by teeth OT - Forensic dentistry OT - Panoramic OT - Radiography OT - Tooth development COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Review Board of the Dow University of Health Sciences (IRB-843/DUHS/Approval/2017/36). Informed consent was obtained from all participants and/or their legal guardians (s). All experiments were performed in accordance with the relevant guidelines and regulations (such as the Declaration of Helsinki). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:37 MHDA- 2026/09/02 05:36 PMCR- 2026/06/22 CRDT- 2026/06/23 01:07 PHST- 2026/04/19 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/23 11:37 [pubmed] PHST- 2026/06/23 01:07 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12903-026-08994-0 [pii] AID - 8994 [pii] AID - 10.1186/s12903-026-08994-0 [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 22;26(1):1652. doi: 10.1186/s12903-026-08994-0. PMID- 42332636 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260908 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Bridging Respiratory Exposures, Asthma, and Environmental Health in Corpus Christi (BREATHE-CC): a prospective cohort study protocol. LID - 10.1186/s12889-026-28265-5 [doi] LID - 2521 AB - BACKGROUND: Childhood asthma disproportionately affects Hispanic children in the United States. Nevertheless, few longitudinal cohorts exist in Gulf Coast communities where environmental exposures may compound sociodemographic vulnerabilities. Corpus Christi, a majority-Hispanic city with high levels of petrochemical industrial operations, reports higher asthma prevalence than state and national averages. BREATHE-CC (Bridging Respiratory Exposures, Asthma, and Environmental Health in Corpus Christi) is a prospective cohort designed to investigate the role of air pollutants, household conditions, and social determinants of health in asthma exacerbations and wheezing phenotypes. METHODS: Approximately 200 children less than 10 years of age with asthma will be enrolled from Driscoll Children's Hospital. Enrolled participants complete baseline assessments and are followed monthly for up to 18 months using a parent-reported modified ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire that captures household exposures, asthma exacerbations, and wheezing episodes. Questionnaire responses will be validated and supplemented with electronic health record (EHR) reviews. Daily air pollutant concentrations (PM(2.5), PM(10), O(3), SO(2)) from the Texas Commission on Environmental Quality (TCEQ) and U.S. Environmental Protection Agency (EPA) monitoring stations will be linked to participants' addresses. Generalized Additive Models (GAMs) and Poisson regressions will assess the associations between air pollutant exposures, household risk factors, asthma exacerbations, and wheezing phenotypes, adjusting for age, sex, body mass index (BMI), and other sociodemographic indicators. Group-Based Trajectory Modeling (GBTM) will identify latent phenotypes of wheezing. DISCUSSION: This is a longitudinal cohort examining Hispanic children residing in the Gulf Coast petrochemical corridor. In particular, the study integrates granular geospatial environmental monitoring to link daily air pollutant exposure levels with asthma exacerbation risk. GBTM will also be used to identify latent wheezing phenotypes, especially focusing on differences between infectious and non-infectious wheezing. Recruitment will occur at a single hospital in the Coastal Bend region with a modest sample size, which may limit generalizability. REGISTRATION: Clinical trial number: not applicable. Open Science Framework [ https://osf.io/tbg6y/overview?view_only=87309518c35b4d78a7bbe79d5fa70ceb ]. CI - (c) 2026. The Author(s). FAU - Warden, Donald E AU - Warden DE AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Meyers, Aidan AU - Meyers A AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Almekhlabi, Hiea AU - Almekhlabi H AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Kuchavaram, Manasa AU - Kuchavaram M AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Richmond, Erin AU - Richmond E AD - Global Institute for Hispanic Health, Corpus Christi, USA. FAU - Allison-Hoien, Mari AU - Allison-Hoien M AD - Global Institute for Hispanic Health, Corpus Christi, USA. FAU - Jin, Lei AU - Jin L AD - College of Science, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Johnson, Natalie AU - Johnson N AD - School of Public Health, Texas A&M University, College Station, USA. FAU - Roberts, Jon AU - Roberts J AD - Department of Pediatric Pulmonology, Driscoll Children's Hospital, Corpus Christi, USA. FAU - Melaram, Rajesh AU - Melaram R AUID- ORCID: 0000-0001-5223-5993 AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. rajesh.melaram@tamucc.edu. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Air Pollutants) SB - IM MH - Humans MH - *Asthma/epidemiology MH - Prospective Studies MH - *Environmental Exposure/adverse effects/analysis MH - Child MH - Male MH - Child, Preschool MH - Female MH - Air Pollutants/analysis/adverse effects MH - Texas/epidemiology MH - *Environmental Health MH - Respiratory Sounds MH - Infant MH - *Hispanic or Latino/statistics & numerical data MH - Research Design MH - Air Pollution/adverse effects PMC - PMC13540882 OTO - NOTNLM OT - Air pollutants OT - Asthma exacerbation OT - Children OT - Household OT - Wheezing COIS- Declarations. Ethics approval and consent to participate: This study adheres to the Declaration of Helsinki. Ethical approval was granted by the DCHIRB (FY2025-85). Written informed consent is obtained from parents/guardians. Study data are collected and managed using REDCap hosted at Texas A&M University - Corpus Christi. REDCap provides audit trails for tracking data changes and user activity. Furthermore, a data use and management protocol has been developed to secure data access and protect personal identifying information. REDCap study IDs are unique to patients, and the linkage between BREATHE-CC ID and DCH ID will be stored on a separate server accessible only to key study personnel. Patient addresses and date of birth will be anonymized by authorized personnel and transformed into calculated variables (age and geocoded address with a jitter). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:37 MHDA- 2026/09/03 05:37 PMCR- 2026/06/23 CRDT- 2026/06/23 01:07 PHST- 2026/04/25 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/09/03 05:37 [medline] PHST- 2026/06/23 11:37 [pubmed] PHST- 2026/06/23 01:07 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12889-026-28265-5 [pii] AID - 28265 [pii] AID - 10.1186/s12889-026-28265-5 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 23;26(1):2521. doi: 10.1186/s12889-026-28265-5. PMID- 42332628 OWN - NLM STAT- Publisher LR - 20260623 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) DP - 2026 Jun 23 TI - Urinary proteomic profiling identifies candidate biomarkers for pediatric MAFLD in comparison with obesity and healthy controls. LID - 10.1186/s12887-026-07070-4 [doi] AB - PURPOSE: This exploratory pilot study, employing a single-center and cross-sectional design, aimed to characterize urinary protein alterations associated with pediatric metabolic-associated fatty liver disease (MAFLD) and to identify preliminary candidate proteins associated with MAFLD status within a cohort of children with obesity. METHODS: In this single-center, cross-sectional observational study, urine samples were collected from 39 children and assigned to three groups: healthy controls (n = 10), simple obesity (n = 14), and obesity with MAFLD (diagnosed by ultrasonography, n = 15). Data-independent acquisition (DIA)-based quantitative proteomics was performed. After quality control, shared proteins across groups were analyzed by one-way ANOVA and trend clustering. Functional enrichment was conducted using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Pearson correlation was used to examine associations between key proteins and clinical metabolic indicators. Exploratory discriminatory potential within this cohort was assessed using Receiver operating characteristic (ROC) curves. RESULTS: A total of 2,824 intersecting proteins were identified, and 49 showed significant differences among the three groups. Trend analysis and fold-change filtering (|log(2)FC| > 0.585) identified 19 core proteins with consistent expression gradients across the healthy, obese, and MAFLD groups. Among these, 6-phosphogluconolactonase (PGLS), dipeptidyl peptidase 7 (DPP7), and complement factor I (CFI) demonstrated notable correlations with liver function markers and glucose-lipid metabolic indices. ROC analysis indicated that PGLS provided the strongest discrimination. CONCLUSION: We performed urinary proteomic profiling to characterize metabolic alterations in pediatric MAFLD. Our analysis identified distinct protein signatures across the HC-OB-MAFLD spectrum, highlighting metabolic dysregulation, oxidative stress, and complement activation as primary features of disease progression. While PGLS, DPP7, and CFI emerged as potential biomarkers, PGLS demonstrated the greatest potential for distinguishing MAFLD from simple obesity in this specific cohort. Due to the small sample size (n = 39) and cross-sectional design, these results provide preliminary molecular insights that require large-scale, longitudinal validation to confirm their clinical utility. TRIAL REGISTRATION: International Traditional Medicine Clinical Trial Registry ITMCTR2025001222, December 31, 2024. Retrospectively registered. CI - (c) 2026. The Author(s). FAU - Zhang, Xiaohui AU - Zhang X AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Zhu, Zhongyi AU - Zhu Z AD - Department of Traditional Chinese Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Zhou, Zhaoxin AU - Zhou Z AD - Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China. FAU - Liu, Chang AU - Liu C AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Du, Lina AU - Du L AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Guo, Ziyun AU - Guo Z AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Pu, Guowei AU - Pu G AD - Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China. FAU - He, Qiang AU - He Q AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. bch_hq@126.com. FAU - Yang, Yan AU - Yang Y AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. yy2303@sina.com. LA - eng GR - No. 2024-2-2095/Capital's Funds for Health Improvement and Research/ PT - Journal Article DEP - 20260623 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM OTO - NOTNLM OT - Childhood obesity OT - Metabolic-associated fatty liver disease (MAFLD) OT - Noninvasive biomarkers OT - Pediatrics OT - Urinary proteomics COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Medical Ethics Committee of Beijing Children's Hospital, Capital Medical University (approval No. [2024]-Y-095-D). The study was registered at the International Traditional Medicine Clinical Trial Registry (ITMCTR2025001222) on December 31, 2024 (Retrospectively registered). Written informed consent was obtained from all participating children and their legal guardians prior to enrollment, in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:34 MHDA- 2026/06/23 11:34 CRDT- 2026/06/23 01:07 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/23 11:34 [medline] PHST- 2026/06/23 11:34 [pubmed] PHST- 2026/06/23 01:07 [entrez] AID - 10.1186/s12887-026-07070-4 [pii] AID - 10.1186/s12887-026-07070-4 [doi] PST - aheadofprint SO - BMC Pediatr. 2026 Jun 23. doi: 10.1186/s12887-026-07070-4. PMID- 42332600 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 22 TI - Self-assessment risk scoring system for early screening of preterm birth in low resource settings. LID - 10.1186/s12884-026-09519-x [doi] LID - 980 AB - INTRODUCTION: Preterm birth is a leading cause of neonatal mortality and morbidity globally. According to the World Health Organization (WHO), 15 million babies were born prematurely in 2010. Indonesia has the fifth-highest number of preterm births in the world, with 675,700 occurring every year. Early screening for preterm birth is crucial, but many health centers in low-resource settings lack the equipment required to do so. This study aims to develop a scoring system that can predict preterm birth based on socio-demographics, nutrition, lifestyle, previous pregnancy history, and maternal condition. The goal is to create a simple, fast, and inexpensive method that can be easily accessed for early screening in low-resource settings. METHODS: This case-control study was conducted between June 2021 and June 2022 at Cipto Mangunkusumo General Hospital, Jakarta. Subjects were categorized into preterm and control groups. Clinical data were obtained through history taking and medical records and analyzed using IBM SPSS 23. Significant variables in bivariate analysis underwent multivariable analysis through logistic regression. The receiver operating characteristics (ROC) indicate how accurately the risk-scoring system performs. The validity of the scoring formula was analyzed using the Hosmer-Lemeshow test. The performance of the score was assessed using the area under the curve parameter. RESULTS: Multivariate analysis showed that socioeconomic level, antenatal visits, history of preterm, hypertension, and weight gain during pregnancy were independent predictors of preterm birth, with an area under the curve of 0.844 (95% CI 0.802-0.885) and p < 0.001, indicating a good predictive ability. Hosmer-Lemeshow test showed a well-fitted model (p = 0.26). Based on the scoring system in this study, the cut-off >/= 4 had a sensitivity and specificity of 81.3% and 82.2%, respectively, in predicting preterm birth. CONCLUSION: Socioeconomic level, history of preterm delivery, antenatal visits, weight gain during pregnancy, and history of hypertension were independent predictors associated with preterm birth. CI - (c) 2026. The Author(s). FAU - Novianti, Lisa AU - Novianti L AUID- ORCID: 0009-0007-5156-8412 AD - Obstetrics and Gynaecology Department, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia. FAU - Irwinda, Rima AU - Irwinda R AUID- ORCID: 0000-0002-6260-6273 AD - Maternal Fetal Division, Obstetrics and Gynaecology Department, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia. rima.irwinda@yahoo.com. FAU - Saroyo, Yudianto Budi AU - Saroyo YB AD - Maternal Fetal Division, Obstetrics and Gynaecology Department, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia. FAU - Hiksas, Rabbania AU - Hiksas R AUID- ORCID: 0000-0001-8740-3918 AD - Obstetrics and Gynaecology Department, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia. LA - eng PT - Journal Article DEP - 20260622 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - *Premature Birth/diagnosis/epidemiology MH - Indonesia/epidemiology MH - Pregnancy MH - Case-Control Studies MH - Risk Assessment/methods MH - Resource-Limited Settings MH - Adult MH - Infant, Newborn MH - ROC Curve MH - Risk Factors PMC - PMC13536780 OTO - NOTNLM OT - Preterm birth OT - Risk-scoring COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethical Committee of the Faculty of Medicine Universitas Indonesia (Letter number S. 71/SPE/IX/2022). This was a retrospective study, thus only clinically relevant information from medical records were restricted. Written informed consent from all participants was waived by the Ethical Committee as this study also did not affect patients' treatment and health. Consent for publication: No consent was taken from patients during their enrollment into the study. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:35 MHDA- 2026/09/02 05:36 PMCR- 2026/06/22 CRDT- 2026/06/23 01:06 PHST- 2024/03/13 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/23 11:35 [pubmed] PHST- 2026/06/23 01:06 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12884-026-09519-x [pii] AID - 9519 [pii] AID - 10.1186/s12884-026-09519-x [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 22;26(1):980. doi: 10.1186/s12884-026-09519-x. PMID- 42332536 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260926 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 25 DP - 2026 Jun 19 TI - Association of triglyceride to high-density lipoprotein cholesterol and low-density lipoprotein to high-density lipoprotein cholesterol ratios with glycemic control in type 2 diabetes mellitus: A cross-sectional study from a Libyan clinical cohort. PG - e49337 LID - 10.1097/MD.0000000000049337 [doi] LID - e49337 AB - Poor glycemic control in type 2 diabetes mellitus (T2DM) is frequently associated with adverse lipid profiles, including elevated triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C). Lipid ratios, including TG/HDL-C (triglycerides/high-density lipoprotein cholesterol) and LDL-C/HDL-C (low-density/ high-density lipoprotein cholesterol), may serve as simple markers of insulin resistance and cardiometabolic risk. This study aimed to investigate the association between glycemic control and lipid parameters, including TG, HDL-C, and lipid ratios, in a Libyan cohort of T2DM patients. In this retrospective cross-sectional study, 363 T2DM patients (140 males, 223 females) aged 18 to 80 years attending a diabetic polyclinic in Benghazi between January 2022 and January 2024 were included. Clinical and biochemical data, including fasting lipid profiles and glycated hemoglobin (HbA1c), were extracted from patient records. Participants were classified according to glycemic control (HbA1c < 7% vs >/=7%). Associations between lipid parameters, lipid ratios, and glycemic control were assessed using multivariable logistic regression adjusted for age, sex, BMI, duration of diabetes, and statin use. Patients with uncontrolled HbA1c (>/=7%) had significantly higher TG/HDL-C ratios (3.79 +/- 2.52 vs 2.92 +/- 2.42; P = .007) and LDL-C/HDL-C ratios (2.55 +/- 1.30 vs 1.95 +/- 1.05; P < .001) compared with those with controlled HbA1c. In multivariable logistic regression analysis, higher low-density lipoprotein cholesterol (LDL-C) levels were significantly associated with uncontrolled HbA1c (OR = 1.02; 95% CI: 1.01-1.03; P < .001). When lipid ratios were evaluated, the LDL-C/HDL-C ratio remained significantly associated with uncontrolled HbA1c (OR = 1.05; 95% CI: 1.02-1.09; P = .003). Lipid ratios, particularly LDL-C/HDL-C, were associated with poor glycemic control in type 2 diabetes mellitus; however, their clinical utility requires further validation in prospective studies. Integrated management of dyslipidemia and glycemic control is essential to reduce cardiovascular complications in this population. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Mahmoud, Sahar H AU - Mahmoud SH AUID- ORCID: 0009-0003-4715-1244 AD - Department of Physiology, Faculty of Medicine, Benghazi University, Benghazi, Libya. FAU - Elfargani, Fatma R AU - Elfargani FR AD - Department of Physiology, Faculty of Medicine, Benghazi University, Benghazi, Libya. FAU - Mohamed, Nagwa AU - Mohamed N AD - Department of Physiology, Faculty of Medicine, Benghazi University, Benghazi, Libya. FAU - Khader, Yousef AU - Khader Y AD - Department of Public Health, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Triglycerides) RN - 0 (Cholesterol, HDL) RN - 0 (Glycated Hemoglobin) RN - 0 (Cholesterol, LDL) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/blood MH - Female MH - Male MH - Cross-Sectional Studies MH - *Triglycerides/blood MH - Middle Aged MH - *Cholesterol, HDL/blood MH - Retrospective Studies MH - *Glycemic Control MH - Aged MH - Glycated Hemoglobin/analysis MH - Aged, 80 and over MH - *Cholesterol, LDL/blood MH - Adult MH - Libya MH - Blood Glucose MH - Young Adult MH - Adolescent PMC - PMC13286382 OTO - NOTNLM OT - HDL-C OT - LDL-C/HDL-C ratio OT - TG/HDL-C ratio OT - dyslipidemia OT - glycemic control OT - inflammation OT - triglycerides OT - type 2 diabetes mellitus COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/06/23 11:35 MHDA- 2026/06/23 12:34 PMCR- 2026/06/19 CRDT- 2026/06/23 01:02 PHST- 2026/03/12 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/23 12:34 [medline] PHST- 2026/06/23 11:35 [pubmed] PHST- 2026/06/23 01:02 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 00005792-202606190-00098 [pii] AID - MD-D-26-03886 [pii] AID - 10.1097/MD.0000000000049337 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 19;105(25):e49337. doi: 10.1097/MD.0000000000049337. PMID- 42332484 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260821 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 25 DP - 2026 Jun 19 TI - Agreement and clinical relevance of mid-upper arm circumference in acute, chronic, and concurrent pediatric malnutrition: A retrospective cross-sectional study. PG - e49335 LID - 10.1097/MD.0000000000049335 [doi] LID - e49335 AB - Mid-upper arm circumference (MUAC) is widely used for screening pediatric malnutrition due to its simplicity and feasibility. Although its relationship with anthropometric indicators including weight-for-height (WFH), body mass index (BMI)-for-age, and height-for-age has been previously examined, the degree of agreement and its clinical implications remain variable. This study aimed to evaluate the agreement and clinical relevance of MUAC in assessing acute, chronic, and concurrent malnutrition. This retrospective cross-sectional study included 473 children (0-18 years) evaluated for malnutrition at a tertiary pediatric gastroenterology clinic. Nutritional status was classified using World Health Organization growth standards based on WFH, BMI-for-age, and height-for-age z-scores. MUAC was analyzed as absolute values and MUAC-for-age z-score categories. Acute malnutrition was identified in 72.9% of participants, chronic malnutrition in 18.2%, and concurrent malnutrition in 8.9%. MUAC classified 83.7% of children as malnourished and detected a higher proportion of mild malnutrition than BMI-for-age and WFH classifications. MUAC severity showed a moderate correlation with WFH classifications in children <5 years (rho = 0.447, P <.001) and a strong correlation with BMI-for-age classifications in those >/= 5 years (rho = 0.649, P <.001). Agreement between MUAC-based severity categories and anthropometric classifications was fair for WFH (kappa = 0.33) and moderate for BMI-for-age (kappa = 0.55). Children with concurrent malnutrition were more frequently classified into moderate or severe MUAC categories (P <.01). MUAC showed fair-to-moderate agreement and moderate-to-strong correlations with BMI-for-age and WFH indicators of acute malnutrition, whereas its associations with chronic malnutrition were weaker. It identifies a higher proportion of children with mild malnutrition and reflects the severity of concurrent malnutrition. These findings support the potential complementary role of MUAC in routine anthropometric assessment and suggest that it may contribute to the early identification of pediatric malnutrition. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Arslan, Melike AU - Arslan M AUID- ORCID: 0000-0002-0107-4699 AD - Division of Pediatric Gastroenterology, Department of Pediatrics, Konya City Hospital, Konya, Turkiye. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Cross-Sectional Studies MH - Retrospective Studies MH - Child, Preschool MH - *Arm/anatomy & histology MH - Infant MH - Female MH - Male MH - Body Mass Index MH - Child MH - *Anthropometry/methods MH - Adolescent MH - *Malnutrition/diagnosis MH - *Child Nutrition Disorders/diagnosis MH - Chronic Disease MH - Nutritional Status MH - Acute Disease MH - Infant, Newborn PMC - PMC13286424 OTO - NOTNLM OT - acute malnutrition OT - anthropometric assessment OT - concurrent malnutrition OT - mid-upper arm circumference (muac) OT - pediatric malnutrition COIS- The authors has no funding and conflicts of interest to declare. EDAT- 2026/06/23 11:37 MHDA- 2026/06/23 18:34 PMCR- 2026/06/19 CRDT- 2026/06/23 01:02 PHST- 2026/03/09 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 11:37 [pubmed] PHST- 2026/06/23 01:02 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 00005792-202606190-00046 [pii] AID - MD-D-26-03621 [pii] AID - 10.1097/MD.0000000000049335 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 19;105(25):e49335. doi: 10.1097/MD.0000000000049335. PMID- 42331937 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261005 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 22 TI - Correlation analysis of blood metabolites and periventricular leukomalacia in preterm infants two weeks postnatally. LID - 10.1038/s41598-026-58150-5 [doi] LID - 28434 AB - Periventricular leukomalacia (PVL) is a neonatal brain injury disease that may cause neurodevelopmental disorders. In this study, our objective was to compare the differences in blood metabolites between preterm infants with and without PVL. We also aimed to screen for potential metabolic markers related to the early identification of PVL. Preterm infants diagnosed with periventricular leukomalacia (PVL) by cranial imaging were assigned to the PVL group (n = 32), while those without a PVL diagnosis were assigned to the control group (n = 68). Blood metabolite levels were measured at 2 weeks postnatally using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Most blood metabolite concentrations were statistically different between the two groups (P < 0.05). The results of the OPLS-DA model identification analysis and validation show that the model is valid. Of the 12 blood metabolites with predicted variable importance (VIP) > 1, those with the highest VIP scores included octadecadienoylcarnitine (C18:2), 3-hydroxy-isovalerylcarnitine (C4DC), 3-oH-octadecylcarnitine (C18OH), 3-hydroxy-cetacylcarnitine (C16OH), Adipylcarnitine (C6DC), and Tyrosine (Tyr). The S-plot shows that the blood metabolites C4DC, Ornithine (Orn), C16OH, and C18:2 are biased towards the two poles. The univariate analysis for cross-validation showed that C18:2, C4DC, C18OH, and C16OH concentrations in blood metabolites were significantly different between the two groups (P < 0.001). The results of multivariate logistic regression analysis showed that a high concentration of Tyr was negatively associated with the occurrence of PVL (P = 0.031), while a longer duration of parenteral nutrition (PN) and a higher Orn concentration were positively correlated with PVL (all P < 0.05). Receiver Operating Characteristic (ROC) curve analysis indicated that C18:2 had a relatively high discriminatory ability for PVL among the detected metabolites, but it did not show independent statistical significance in the multivariate logistic regression analysis. The most significant difference in the blood metabolite concentrations between the two groups was observed for C18:2. Enrichment analysis showed that fatty acid degradation is the most likely major mechanistic pathway involved in the development of PVL. There is a certain correlation between early blood metabolite levels and PVL occurrence in premature infants. Although C18:2 shows a certain discriminatory ability, the value of it as an early detection indicator still needs further research. CI - (c) 2026. The Author(s). FAU - Zhang, Caiyu AU - Zhang C AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. FAU - Yu, Muchun AU - Yu M AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. FAU - He, Lu AU - He L AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. FAU - Sun, Zhihong AU - Sun Z AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. FAU - Sun, Huiqing AU - Sun H AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. s_huiqing@sina.com. LA - eng GR - YXKC2021022/Henan Province Young and Middle-Aged Health Science and Technology Innovation Leading Talent Training Project/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260622 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Leukomalacia, Periventricular/blood/diagnosis MH - Infant, Newborn MH - Female MH - Male MH - *Infant, Premature/blood MH - Biomarkers/blood MH - Tandem Mass Spectrometry PMC - PMC13562565 OTO - NOTNLM OT - Gestational age OT - Metabolites OT - Periventricular leukomalacia OT - Preterm infants OT - Tyrosine COIS- Declarations. Competing interests: The authors have no relevant financial or non-financial interests to disclose. Ethical approval: This study was approved by the Ethics Committee of Henan Children's Hospital (approval number: 2024- KY- 0030) and followed the principles of the Declaration of Helsinki. The purpose and details of the study were explained to the families of all infants participating in the study, and written informed consent was signed. Consent for publication: All authors, parents or legal guardians of the child have consented to publication. EDAT- 2026/06/23 00:34 MHDA- 2026/09/11 05:36 PMCR- 2026/06/22 CRDT- 2026/06/22 23:37 PHST- 2025/11/25 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/11 05:36 [medline] PHST- 2026/06/23 00:34 [pubmed] PHST- 2026/06/22 23:37 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1038/s41598-026-58150-5 [pii] AID - 58150 [pii] AID - 10.1038/s41598-026-58150-5 [doi] PST - epublish SO - Sci Rep. 2026 Jun 22;16(1):28434. doi: 10.1038/s41598-026-58150-5. PMID- 42331896 OWN - NLM STAT- Publisher LR - 20260622 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jun 22 TI - Comprehensive behavioral and demographic correlates in myopia risk among Tibetan adolescents: a machine learning analysis using non‑cycloplegic refraction. LID - 10.1038/s41598-026-58744-z [doi] AB - Myopia is a global public health concern, especially among children and adolescents. This exploratory study aimed to develop a myopia risk prediction model for Tibetan adolescents using interpretable machine learning, while explicitly acknowledging the methodological limitations of non-cycloplegic refraction and self-reported data. We included 735 Tibetan adolescents. An XGBoost algorithm was used to build a binary classification model, with the SHAP method applied for feature interpretation. Data were split into 80% training and 20% test sets to analyze associations between behavioral, demographic factors, and myopia risk. Myopia was defined using non-cycloplegic autorefraction (uncorrected visual acuity < 5.0 [logMAR 0.0] and spherical equivalent /=50% reduction in seizure frequency or seizure freedom at six months. EEG changes were compared between responders and non-responders, and receiver operating characteristic analysis was performed to evaluate the association between early EEG changes and clinical outcome. RESULTS: Thirty-four patients were included, of whom 23 (67.6%) were classified as responders at six months. Baseline EEG characteristics did not differ between responders and non-responders. At one month, responders showed a significant reduction in IED index, whereas no significant change was observed in non-responders. A reduction in IED index of approximately 40% was associated with clinical response, demonstrating good discriminative performance. Changes in background EEG activity were observed in both groups and were not associated with seizure outcome. CONCLUSION: Early reduction in IED index on routine sleep EEG is associated with favorable clinical response to the ketogenic diet. Routine EEG assessment may offer supportive electrophysiological information during early follow-up of KD therapy in pediatric drug-resistant epilepsy. CI - Copyright (c) 2026 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. FAU - Yavuz, Merve AU - Yavuz M AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: drmerveyavuz@hotmail.com. FAU - Unalp, Aycan AU - Unalp A AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: aycan.unalp67@gmail.com. FAU - Gulagiz, Feyza AU - Gulagiz F AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: feyzagulagiz@gmail.com. FAU - Guzin, Yigithan AU - Guzin Y AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: yguzin@hotmail.com. FAU - Yilmaz, Unsal AU - Yilmaz U AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: drunsalyilmaz@yahoo.com. LA - eng PT - Journal Article DEP - 20260610 PL - England TA - Seizure JT - Seizure JID - 9306979 SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - Male MH - *Electroencephalography MH - Female MH - *Drug Resistant Epilepsy/diet therapy/physiopathology MH - Retrospective Studies MH - Child MH - Treatment Outcome MH - Child, Preschool MH - *Brain/physiopathology MH - Adolescent MH - Seizures/physiopathology/diet therapy OTO - NOTNLM OT - Epilepsy OT - Interictal epileptiform discharge index OT - Ketogenic diet COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/22 21:07 MHDA- 2026/07/16 12:40 CRDT- 2026/06/22 18:08 PHST- 2026/02/11 00:00 [received] PHST- 2026/05/02 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/16 12:40 [medline] PHST- 2026/06/22 21:07 [pubmed] PHST- 2026/06/22 18:08 [entrez] AID - S1059-1311(26)00176-7 [pii] AID - 10.1016/j.seizure.2026.06.004 [doi] PST - ppublish SO - Seizure. 2026 Aug;140:149-156. doi: 10.1016/j.seizure.2026.06.004. Epub 2026 Jun 10. PMID- 42330798 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1878-7487 (Electronic) IS - 1752-928X (Linking) VI - 121 DP - 2026 Jul TI - Dental age estimation in the Chhattisgarhi population: A comparative study of Demirjian and Willems methods. PG - 103195 LID - S1752-928X(26)00127-7 [pii] LID - 10.1016/j.jflm.2026.103195 [doi] AB - BACKGROUND: Forensic identification, pediatric dentistry, and medico-legal investigations all often utilize dental age estimation. Demirjian and Willems methods are frequently used when estimating dental maturity; however, their accuracy varies across different groups, pointing to the need for population specific validation. AIM: Aim of the current study was to compare and assess the reliability of the Demirjian and Willems for estimating dental age in the children from the Indian state of Chhattisgarh. METHODS: A retrospective cross-sectional study was conducted using 142 orthopantomograms of children aged 10-16 years. Dental age was estimated using Demirjian and Willems methods based on the developmental stages of the seven left mandibular permanent teeth. The accuracy was assessed using mean error (ME) and mean absolute error (MAE). Pearson correlation and paired t-tests were used to evaluate statistical analysis. RESULTS: The Demirjian method showed a tendency to overestimate age in younger individuals and underestimate age in older age groups. The Willems method demonstrated comparatively smaller deviations from chronological age and often yielded better and more reliable age estimates. Both methods show positive correlation between chronological age and dental age. CONCLUSION: The Willems method showed higher accuracy than the Demirjian method in this Chhattisgarhi population for dental age estimation. CI - Copyright (c) 2026 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved. FAU - Tiwari, Archana AU - Tiwari A AD - Department of Forensic Medicine and Toxicology All India Institute of Medical Sciences Raipur, Chhattisgarh, 492099, India. Electronic address: stiwari98archana@gmail.com. FAU - Indurkar, Shubham Kumar AU - Indurkar SK AD - Department of Forensic Medicine and Toxicology Raipur Institute of Medical Sciences, Raipur, Chhattisgarh, 493441, India. Electronic address: shubhamindurkar55@gmail.com. FAU - Chavali, Krishnadutt AU - Chavali K AD - Department of Forensic Medicine and Toxicology All India Institute of Medical Sciences Raipur, Chhattisgarh, 492099, India. Electronic address: drkhchavali@aiimsraipur.edu.in. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260621 PL - England TA - J Forensic Leg Med JT - Journal of forensic and legal medicine JID - 101300022 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Child MH - Radiography, Panoramic MH - Adolescent MH - Retrospective Studies MH - India MH - Cross-Sectional Studies MH - Male MH - Female MH - Reproducibility of Results MH - Forensic Dentistry MH - *Tooth/growth & development/diagnostic imaging MH - Tooth Calcification OTO - NOTNLM OT - Demirjian method OT - Dental age estimation OT - Forensic odontology OT - Orthopantomogram OT - Willems method EDAT- 2026/06/22 21:07 MHDA- 2026/07/07 18:56 CRDT- 2026/06/22 18:07 PHST- 2026/05/29 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/07/07 18:56 [medline] PHST- 2026/06/22 21:07 [pubmed] PHST- 2026/06/22 18:07 [entrez] AID - S1752-928X(26)00127-7 [pii] AID - 10.1016/j.jflm.2026.103195 [doi] PST - ppublish SO - J Forensic Leg Med. 2026 Jul;121:103195. doi: 10.1016/j.jflm.2026.103195. Epub 2026 Jun 21. PMID- 42330757 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260915 IS - 1472-6491 (Electronic) IS - 1472-6483 (Linking) VI - 53 IP - 3 DP - 2026 Sep TI - Effect of a pro-fertility diet combined with omega-3 supplementation on embryo quality in infertile women undergoing IVF: a randomized controlled trial. PG - 105661 LID - S1472-6483(26)00202-6 [pii] LID - 10.1016/j.rbmo.2026.105661 [doi] AB - RESEARCH QUESTION: Does adherence to a pro-fertility diet (PFD) combined with omega-3 supplementation improve the fertilization rate and embryo quality in infertile women undergoing IVF? DESIGN: A randomized, single-blind, parallel clinical trial was conducted from June 2024 to June 2025 among 180 infertile women aged 18-42 years undergoing IVF at Hazrat Maryam Fertility Center, Isfahan, Iran. Participants were randomized (1:1) to receive either a structured PFD with daily omega-3 (1000 mg), vitamin D (1000 IU), folate (1 mg) and vitamin B12 (500 microg) supplementation for 60 days, or general dietary advice based on the Healthy Eating Plate model plus 500 microg/day folic acid. Fertilization rate, embryo formation rate and embryo quality (grades A-D) were evaluated. RESULTS: Compared with controls, the intervention group had significantly higher fertilization rates (0.81 +/- 0.16 versus 0.66 +/- 0.24; P < 0.001) and embryo formation rates (0.79 +/- 0.26 versus 0.62 +/- 0.30; P < 0.001), and an increased number of embryos formed (3.78 +/- 2.34 versus 2.22 +/- 1.46; P < 0.001). Additionally, the proportion of grade A embryos was markedly higher in the intervention group (45.2% versus 21.7%; P = 0.003). CONCLUSION: Adherence to a PFD combined with omega-3 supplementation significantly improved the fertilization rate and embryo quality in women undergoing IVF. This combined nutritional intervention represents a safe, feasible and cost-effective adjunctive approach to optimize embryological outcomes in assisted reproductive technology. CI - Copyright (c) 2026 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. FAU - Ghadimi Yari, Mahnaz AU - Ghadimi Yari M AD - Nutrition and Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Ghasemi-Tehrani, Hatav AU - Ghasemi-Tehrani H AD - Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Feizi, Awat AU - Feizi A AD - Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Ziaei, Rahele AU - Ziaei R AD - Nutrition and Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Derakhshan, Marzieh AU - Derakhshan M AD - Shahid Beheshti Fertility Center, Department of Anatomy and Reproductive Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Rouhani, Mohammad H AU - Rouhani MH AD - Nutrition and Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: sm_rouhani@nutr.mui.ac.ir. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260227 PL - Netherlands TA - Reprod Biomed Online JT - Reproductive biomedicine online JID - 101122473 RN - 0 (Fatty Acids, Omega-3) RN - 935E97BOY8 (Folic Acid) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Pregnancy MH - Young Adult MH - *Diet MH - *Dietary Supplements MH - *Fatty Acids, Omega-3/administration & dosage MH - *Fertilization in Vitro/methods MH - Folic Acid/administration & dosage MH - *Infertility, Female/therapy MH - Iran MH - Pregnancy Rate MH - Single-Blind Method OTO - NOTNLM OT - Assisted reproductive technology OT - Embryo quality OT - IVF OT - Infertility OT - Omega-3 fatty acids OT - Pro-fertility diet EDAT- 2026/06/22 21:07 MHDA- 2026/09/03 23:36 CRDT- 2026/06/22 18:06 PHST- 2025/10/21 00:00 [received] PHST- 2026/01/23 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/09/03 23:36 [medline] PHST- 2026/06/22 21:07 [pubmed] PHST- 2026/06/22 18:06 [entrez] AID - S1472-6483(26)00202-6 [pii] AID - 10.1016/j.rbmo.2026.105661 [doi] PST - ppublish SO - Reprod Biomed Online. 2026 Sep;53(3):105661. doi: 10.1016/j.rbmo.2026.105661. Epub 2026 Feb 27. PMID- 42330079 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260824 IS - 1940-087X (Electronic) IS - 1940-087X (Linking) IP - 232 DP - 2026 Jun 2 TI - Mental Health, Sleep, and Eating Patterns Among Saudi Adults During Ramadan Fasting - A Cross-Sectional Study. LID - 10.3791/70640 [doi] AB - Ramadan fasting involves marked shifts in sleep-wake cycles, dietary habits, and daily routines, all of which may influence psychological well-being. Although Ramadan represents a naturalistic model of structured, time-restricted fasting, limited research in Saudi Arabia has explored how sociodemographic factors shape mental health, sleep, and eating behaviors during this period. This study examined these outcomes in adults across multiple regions of the country. A descriptive cross-sectional survey was conducted in March 2025 among adults aged 18-60 years residing in Saudi Arabia who observed daytime fasting during Ramadan. A total of 464 participants were recruited through convenience sampling. Data were collected using a validated, culturally adapted questionnaire that assessed psychological well-being, sleep patterns, and eating behaviors. Analyses included descriptive statistics, chi-square tests, and multivariable logistic regression, with p < 0.05 as the significance threshold. Most respondents were female (56.5%) and aged 18-40 years (77.1%). Female sex was significantly associated with depressive feelings and reduced interest (p < 0.05) and independently predicted psychological distress (AOR = 1.35, 95% CI: 1.08-1.72). Adults aged 26-39 and 40-60 years showed higher odds of sleep disturbance and altered eating behaviors (p < 0.05). Participants from the Eastern region demonstrated elevated odds of psychological distress (AOR = 1.80), sleep disturbances (AOR = 2.05), and changes in eating patterns (AOR = 1.50). Employment status was associated with daytime fatigue and non-hunger-driven eating patterns. Ramadan-related lifestyle changes are associated with measurable variations in psychological well-being, sleep quality, and eating behavior. Women, middle-aged adults, and residents of the eastern region appeared to be more vulnerable to these effects. Tailored public health strategies promoting mental health, sleep hygiene, and healthy eating during altered daily routines may help mitigate these impacts. FAU - Albaik, Mai AU - Albaik M AD - Department of Chemistry, Preparatory Year Program, Batterjee Medical College; mai.albaik@bmc.edu.sa. FAU - Sulaiman, Sarah Ali AU - Sulaiman SA AD - General Medicine Practice Program, Batterjee Medical College. FAU - Alyamani, Shaza Abdullah AU - Alyamani SA AD - Department of Biology, Preparatory Year Program, Batterjee Medical College. FAU - Thalib, Husna Irfan AU - Thalib HI AD - General Medicine Practice Program, Batterjee Medical College. FAU - Tahir, Khadijah AU - Tahir K AD - General Medicine Practice Program, Batterjee Medical College. FAU - Hifni, Badriah Abdullah AU - Hifni BA AD - Department of Biology, Preparatory Year Program, Batterjee Medical College. LA - eng PT - Journal Article PT - Video-Audio Media DEP - 20260602 PL - United States TA - J Vis Exp JT - Journal of visualized experiments : JoVE JID - 101313252 SB - IM MH - Humans MH - Adult MH - Saudi Arabia MH - Cross-Sectional Studies MH - Female MH - Male MH - *Sleep/physiology MH - Young Adult MH - Middle Aged MH - *Feeding Behavior/physiology/psychology MH - Adolescent MH - *Fasting/psychology/physiology MH - *Mental Health MH - *Islam MH - Intermittent Fasting EDAT- 2026/06/22 19:01 MHDA- 2026/06/22 19:02 CRDT- 2026/06/22 14:04 PHST- 2026/06/22 19:02 [medline] PHST- 2026/06/22 19:01 [pubmed] PHST- 2026/06/22 14:04 [entrez] AID - 10.3791/70640 [doi] PST - epublish SO - J Vis Exp. 2026 Jun 2;(232). doi: 10.3791/70640. PMID- 42329961 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Dietary supplement consumption among active individuals in Saudi Arabia. PG - e0351208 LID - 10.1371/journal.pone.0351208 [doi] LID - e0351208 AB - BACKGROUND: Despite the increasing use of dietary supplements in Saudi Arabia, accurate information on their consumption patterns and predictors is essential for effective policy planning. OBJECTIVE: This study aimed to estimate the prevalence of dietary supplement consumption, assess perceptions regarding their health effects, and identify demographic, health-related, and knowledge- and practice-based factors influencing their use among active individuals in Saudi Arabia. METHODS: This cross-sectional study identified predictors of dietary supplement consumption using a Likert-scale questionnaire adapted from validated local and international tools with minor modifications. Structural equation modeling was conducted by defining multiple sets of regression equations. The analyses were performed using R software (Version 4.1.2) with the lavaan and semPlot packages. A two-tailed p-value < 0.05 was considered statistically significant. RESULTS: A total of 3,800 active individuals from 13 Saudi Arabian regions participated in this study. The prevalence of dietary supplement use among active individuals was 63.82%. Health characteristics and knowledge and practice domains showed a highly significant influence on supplement consumption, whereas the demographic domain did not show a significant association in the structural equation model, although several demographic variables were significantly associated with supplement use in bivariate analysis. CONCLUSION: The prevalence of dietary supplement use among physically active individuals in Saudi Arabia exceeded the prevalence rates reported in several international populations, with more than three out of every five participants indicating use of dietary supplements. CI - Copyright: (c) 2026 Alsayegh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Alsayegh, Abdulrahman A AU - Alsayegh AA AUID- ORCID: 0000-0001-6948-4582 AD - Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Alzaben, Abeer S AU - Alzaben AS AUID- ORCID: 0000-0001-9813-1524 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Abu Haddash, Yahya M AU - Abu Haddash YM AD - Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Busayli, Abdulrahman M AU - Busayli AM AD - Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Chandika, Rama M AU - Chandika RM AD - Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Alsuhaibani, Munirah N AU - Alsuhaibani MN AD - Saudi Food and Drug Authority, Riyadh, Kingdom of Saudi Arabia. FAU - Albishi, Sara A AU - Albishi SA AUID- ORCID: 0009-0001-7930-2743 AD - Clinical Nutrition Department, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al-Batin, Saudi Arabia. FAU - Hanbazaza, Mahitab A AU - Hanbazaza MA AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Abuzaid, Omar I AU - Abuzaid OI AD - Department of Clinical Nutrition, College of Applied Medical Sciences, Imam Abdulrahman bin Faisal University, Dammam, Kingdom of Saudi Arabia. FAU - Alkhalaf, Majed M AU - Alkhalaf MM AD - Executive Directorate of Public Health Policies and Regulations at Saudi Public Health Authority, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260622 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Cross-Sectional Studies MH - *Dietary Supplements/statistics & numerical data MH - Saudi Arabia MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires/statistics & numerical data MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - *Exercise/statistics & numerical data PMC - PMC13286177 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/22 19:00 MHDA- 2026/06/22 19:01 PMCR- 2026/06/22 CRDT- 2026/06/22 13:42 PHST- 2025/05/24 00:00 [received] PHST- 2026/05/24 00:00 [accepted] PHST- 2026/06/22 19:01 [medline] PHST- 2026/06/22 19:00 [pubmed] PHST- 2026/06/22 13:42 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - PONE-D-25-22005 [pii] AID - 10.1371/journal.pone.0351208 [doi] PST - epublish SO - PLoS One. 2026 Jun 22;21(6):e0351208. doi: 10.1371/journal.pone.0351208. eCollection 2026. PMID- 42329656 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260908 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 180 IP - 9 DP - 2026 Sep 1 TI - Obesity Management Pharmacotherapies and Lifestyle Treatment for Pediatric Obesity Management: A Systematic Review and Network Meta-Analysis. PG - 961-974 LID - 10.1001/jamapediatrics.2026.2248 [doi] AB - IMPORTANCE: Pediatric obesity is a global health challenge. Although health behavior and lifestyle treatment (HBLT) is foundational, the comparative effectiveness of HBLT, various pharmacotherapies, and their combinations remains unclear. OBJECTIVE: To compare the effectiveness of obesity management pharmacotherapies, structured lifestyle treatment, and their combinations on weight management outcomes in children and adolescents living with obesity. DATA SOURCES: A systematic search was conducted in 4 electronic databases (Embase, CENTRAL, PsycINFO, and PubMed) from inception to June 17, 2025. DATA SELECTION: Randomized clinical trials (RCTs) involving children and adolescents (aged 10-19 years) with obesity were selected. Interventions included lifestyle treatment (HBLT and counseling), obesity management pharmacotherapies (glucagon-like peptide-1 receptor agonists, metformin, orlistat, phentermine topiramate), or their combination vs control. DATA EXTRACTION AND SYNTHESIS: Data were extracted and validity assessed according to PRISMA guidelines. A random-effects network meta-analysis was used to pool data. Meta-regression was used to explore outcome moderators. MAIN OUTCOMES AND MEASURES: Primary outcomes were body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and BMI z score; secondary outcomes included waist circumference (WC), fat mass (FM), and lean mass (LM). RESULTS: A total of 42 RCTs with 3835 participants (median [IQR] age, 14.5 [13.3-15.1] years; 2270 female [59.2%]) were included. Treatments combining pharmacotherapy and lifestyle treatment demonstrated the greatest efficacy across all adiposity-related outcomes. Semaglutide plus counseling was associated with the largest BMI reduction (mean difference, -8.31; 95% CI, -12.33 to -4.28) and BMI z score reduction (mean difference, -1.80; 95% CI, -2.39 to -1.21), although this estimate was based on a limited number of studies. All pharmacological treatments were more effective when paired with lifestyle treatment, associated with significantly greater BMI and BMI z score reductions than the same medications alone. Based on the primary analysis, HBLT as monotherapy was associated with substantial decreases in BMI (mean difference, -3.85; 95% CI, -4.91 to -2.80) and BMI z score (mean difference, -0.89; 95% CI, -1.17 to -0.61) vs control. CONCLUSIONS AND RELEVANCE: Finding of this systematic review and network meta-analysis suggest that combining lifestyle treatment with obesity management medications was associated with the greatest short-term (typically 6 to 12 months) weight reduction in adolescents with obesity. HBLT remained an indispensable component of any effective weight management, delivering meaningful weight loss and healthier body composition on its own. Combined with lifestyle treatment, pharmacotherapy was a key component, not solely an adjunct, associated with the greatest BMI and BMI z score improvements, and long-term sustainability and safety were monitored. FAU - Wan, Ke-Wen AU - Wan KW AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. AD - Dr Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Lei, Evander Fung-Chau AU - Lei EF AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. AD - Dr Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Liu, Ying AU - Liu Y AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Taddese, Asefa Adimasu AU - Taddese AA AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Ip, Patrick AU - Ip P AD - Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Torbahn, Gabriel AU - Torbahn G AD - Department of Pediatrics, Paracelsus Medical University, Klinikum Nurnberg, Universitatsklinik der Paracelsus Medizinischen Privatuniversitat Nurnberg, Nuremberg, Germany. AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity research unit, Paracelsus Medical University, Salzburg, Austria. FAU - Weghuber, Daniel AU - Weghuber D AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity research unit, Paracelsus Medical University, Salzburg, Austria. FAU - Huang, Wendy Y AU - Huang WY AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. AD - Dr Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Tam, Bjorn T AU - Tam BT AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. AD - Dr Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. LA - eng PT - Journal Article PT - Network Meta-Analysis PT - Systematic Review PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 RN - 0 (Anti-Obesity Agents) RN - 9100L32L2N (Metformin) RN - 53AXN4NNHX (Semaglutide) SB - IM MH - Humans MH - Child MH - *Pediatric Obesity/therapy/drug therapy MH - Adolescent MH - *Anti-Obesity Agents/therapeutic use MH - *Life Style MH - *Obesity Management/methods MH - Combined Modality Therapy MH - Body Mass Index MH - Metformin/therapeutic use MH - Semaglutide PMC - PMC13288192 COIS- Conflict of Interest Disclosures: Dr Torbahn reported having a board membership of the Working Group Obesity in Childhood and Adolescence of the German Association for the Study of Obesity; being a co-opted board member of the European Childhood Obesity Group; and receiving travel grants or reimbursements from the European Association for the Study of Obesity, the German Association for the Study of Obesity, and the European Childhood Obesity Group outside the submitted work. Dr Weghuber reported receiving consulting fees from Novo Nordisk, Eli Lilly, and Rhythm Pharmaceuticals outside the submitted work. No other disclosures were reported. EDAT- 2026/06/22 13:42 MHDA- 2026/09/08 17:36 PMCR- 2027/06/22 CRDT- 2026/06/22 11:33 PHST- 2026/09/08 17:36 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 11:33 [entrez] PHST- 2027/06/22 00:00 [pmc-release] AID - 2850145 [pii] AID - poi260032 [pii] AID - 10.1001/jamapediatrics.2026.2248 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Sep 1;180(9):961-974. doi: 10.1001/jamapediatrics.2026.2248. PMID- 42329506 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 1573-7365 (Electronic) IS - 0885-7490 (Print) IS - 0885-7490 (Linking) VI - 41 IP - 1 DP - 2026 Jun 22 TI - Treatment strategies, radiological recovery, and neurodevelopmental outcomes in paediatric Maple Syrup Urine Disease: a 20-year single-centre experience from Turkiye. LID - 10.1007/s11011-026-01896-8 [doi] LID - 140 AB - Maple Syrup Urine Disease (MSUD) is a rare autosomal recessive metabolic disorder characterised by defective branched-chain amino acid (BCAA) catabolism, leading to neurotoxicity, recurrent metabolic crises, and neurodevelopmental impairment. Evidence on long-term outcomes in paediatric cohorts, particularly with pharmacological adjuncts such as sodium phenylbutyrate (NaPBA) and radiological recovery, remains limited. We undertook a retrospective review of 13 paediatric patients with MSUD (69.2% classic phenotype, 30.8% intermittent) followed at a tertiary metabolic centre in Turkiye between 2003 and 2022. Demographic, biochemical, neurodevelopmental, neuroimaging, and genetic data were evaluated, with specific attention to dietary management, haemodialysis during acute decompensation, and NaPBA therapy. All patients exhibited neurodevelopmental delay, which was more pronounced in the classic phenotype. Milestone-level analysis demonstrated delays in walking (85%), sentence formation (92.3%), and toilet training (92.3%). One year after dietary intervention, mean plasma concentrations of leucine, isoleucine, and valine decreased by 60.9%, 55.9%, and 65.0%, respectively (p < 0.01). Haemodialysis during metabolic crises rapidly reduced leucine (- 73.8%) and ammonia (- 66%), though was more frequently required in patients with the classic phenotype. NaPBA treatment was associated with lower leucine levels during follow-up (p < 0.05). Baseline MRI abnormalities were identified in 87% of patients; 57% showed complete resolution post-treatment, with partial radiological improvement observed alongside clinical follow-up. A phenotype-specific approach combining early dietary intervention, timely haemodialysis in acute crises, and selective use of NaPBA may support metabolic stabilisation and radiological improvement in selected patients. Larger multicentre studies are warranted to validate these findings and refine management protocols. CI - (c) 2026. The Author(s). FAU - Uylas, Kemal AU - Uylas K AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Yazici, Havva AU - Yazici H AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Altinok, Yasemin Atik AU - Altinok YA AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Celik, Merve Yoldas AU - Celik MY AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Karapinar, Fehime Erdem AU - Karapinar FE AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Ozkaya, Pinar Yazici AU - Ozkaya PY AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Isik, Esra AU - Isik E AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Eraslan, Cenk AU - Eraslan C AD - Department of Radiology, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Canda, Ebru AU - Canda E AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Cogulu, Ozgur AU - Cogulu O AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Karapinar, Bulent AU - Karapinar B AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Habif, Sara AU - Habif S AD - Department of Biochemistry, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Coker, Mahmut AU - Coker M AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Ucar, Sema Kalkan AU - Ucar SK AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. semakalkan@hotmail.com. LA - eng PT - Journal Article DEP - 20260622 PL - United States TA - Metab Brain Dis JT - Metabolic brain disease JID - 8610370 RN - 0 (Phenylbutyrates) RN - GMW67QNF9C (Leucine) SB - IM MH - Humans MH - *Maple Syrup Urine Disease/diagnostic imaging/therapy/blood MH - Female MH - Retrospective Studies MH - Male MH - Treatment Outcome MH - Infant MH - Child, Preschool MH - Phenylbutyrates/therapeutic use MH - Magnetic Resonance Imaging MH - Child MH - Leucine/blood PMC - PMC13287102 OTO - NOTNLM OT - Branched-chain amino acids OT - Haemodialysis OT - MRI OT - Maple syrup urine disease OT - Neurodevelopment OT - Sodium phenylbutyrate COIS- Declarations. Ethical declarations: The study protocol was approved by the Ege University Medical Research Ethics Committee (approval date: 09.09.2022, decision number: 22-9 T/30) and was conducted in accordance with the principles of the Declaration of Helsinki. Competing interests: The authors declare no competing interests. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 19:12 PMCR- 2026/06/22 CRDT- 2026/06/22 11:17 PHST- 2026/01/07 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/22 19:12 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 11:17 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1007/s11011-026-01896-8 [pii] AID - 1896 [pii] AID - 10.1007/s11011-026-01896-8 [doi] PST - epublish SO - Metab Brain Dis. 2026 Jun 22;41(1):140. doi: 10.1007/s11011-026-01896-8. PMID- 42329372 OWN - NLM STAT- MEDLINE DCOM- 20261025 LR - 20261028 IS - 1435-165X (Electronic) IS - 1018-8827 (Print) IS - 1018-8827 (Linking) VI - 35 IP - 10 DP - 2026 Oct TI - The weight concerns scale in Australian adolescents: Factor structure, gender invariance, and screening utility. PG - 3313-3323 LID - 10.1007/s00787-026-03101-8 [doi] AB - Despite the increased incidence of disordered eating among adolescents and low help-seeking rates, there is currently a lack of evidence supporting use of screening tools for this population. The present study aimed to address this gap by examining the factor structure, gender invariance, and psychological correlates of the Weight Concerns Scale (WCS) in a large sample of Australian adolescents to evaluate its potential suitability as a screening tool. Participants (n = 1022) aged 12-17 (M(age) = 14.73; SD = 1.55) were recruited from five public secondary schools in South Australia between May and August 2023. All participants completed the WCS and psychological measures of life satisfaction, resilience, psychological distress, self-injurious thoughts and behaviours. Confirmatory factor analysis replicated the original one-factor structure: chi(2)(5) = 44.83, p < .001, RMSEA = 0.09, CFI = 0.99. Measurement non-invariance was found by gender and socio-economic-status, suggesting the scale functions differently across these subgroups. A cut-off score of >/= 47 on WCS was associated with elevated psychological distress across all groups except for boys from lower socio-economic-status backgrounds. The present study is the first to apply confirmatory factor analysis to the WCS in adolescents. Future research needs to establish validity of the WCS as a screen in adolescents in terms of associations with ED psychopathology and behaviours. In addition, validation against diagnostic interview is crucial to establishing the WCS as a screening tool. CI - (c) 2026. The Author(s). FAU - Radunz, Marcela AU - Radunz M AUID- ORCID: 0000-0002-2858-0313 AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. marcela.radunz@flinders.edu.au. FAU - Jabs, Maya AU - Jabs M AUID- ORCID: 0009-0000-8369-1086 AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. FAU - King, Daniel L AU - King DL AUID- ORCID: 0000-0002-1762-2581 AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. FAU - Wade, Tracey D AU - Wade TD AUID- ORCID: 0000-0003-4402-770X AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. LA - eng PT - Journal Article DEP - 20260622 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Factor Analysis, Statistical MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Psychometrics MH - Child MH - Sex Factors MH - Australia MH - *Psychiatric Status Rating Scales/standards MH - Surveys and Questionnaires MH - South Australia MH - Mass Screening MH - *Body Weight MH - Psychological Distress PMC - PMC13696600 OTO - NOTNLM OT - Adolescents OT - Eating disorders OT - Factor structure OT - Screening tool OT - Weight concerns COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/22 13:44 MHDA- 2026/10/25 17:31 PMCR- 2026/06/22 CRDT- 2026/06/22 11:13 PHST- 2025/05/07 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/10/25 17:31 [medline] PHST- 2026/06/22 13:44 [pubmed] PHST- 2026/06/22 11:13 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1007/s00787-026-03101-8 [pii] AID - 3101 [pii] AID - 10.1007/s00787-026-03101-8 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2026 Oct;35(10):3313-3323. doi: 10.1007/s00787-026-03101-8. Epub 2026 Jun 22. PMID- 42328216 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 0974-7052 (Print) IS - 0975-1904 (Electronic) IS - 0974-7052 (Linking) VI - 19 IP - 3 DP - 2026 Mar TI - Association Between Junk Food Consumption and Behavioral Outcomes in 10-15-year-old Children: A Cross-sectional Questionnaire-based Study. PG - 318-323 LID - 10.5005/jp-journals-10005-3474 [doi] AB - BACKGROUND: Dietary habits and food consumption patterns have long been a focus of interest for both researchers and healthcare professionals. In recent years, growing awareness of the role of nutrition in overall well-being, along with a noticeable rise in diet-related health problems, has intensified this focus. Furthermore, increased concern is surfacing regarding the effect of junk food has on the behavior patterns among children; however, there is limited evidence. The present questionnaire study aims to investigate the association between junk food consumption and behavioral issues among 10-15-year-old children attending schools in and around Rajanagaram, Andhra Pradesh. METHODS: A cross-sectional study was conducted among 1,500 students using a validated dietary questionnaire and the Strengths and Difficulties Questionnaire (SDQ) adolescent self-report version. Junk food consumption (based on IAP guidelines) and behavioral categories were evaluated from the reported questionnaires, and the association between the two variables was analyzed statistically using Chi-square and Pearson correlation tests. RESULTS: Moderate junk food consumption was reported by 71.3% of children, with 11.8% reporting severe intake. SDQ revealed 81.6% had abnormal behavior scores, predominantly hyperactivity (54.78%) and conduct problems (67.02%). Although Pearson correlation was statistically nonsignificant (p = 0.963), a trend of increased behavioral issues with higher junk food intake was observed. CONCLUSION: A high prevalence of behavioral disturbances was seen among children with moderate to severe junk food consumption. Educational and policy-based interventions focusing on nutrition are urgently needed. HOW TO CITE THIS ARTICLE: Markapurapu BS, Balakrishnan V, Martha S, et al. Association Between Junk Food Consumption and Behavioral Outcomes in 10-15-year-old Children: A Cross-sectional Questionnaire-based Study. Int J Clin Pediatr Dent 2026;19(3):318-323. CI - Copyright (c) 2026; The Authors. FAU - Markapurapu, Baba S AU - Markapurapu BS AUID- ORCID: 0009-0000-0031-1202 AD - Department of Pediatric and Preventive Dentistry, Dr NTR University of Health Sciences, Vijayawada, Andhra Pradesh, India. FAU - Balakrishnan, Veena AU - Balakrishnan V AUID- ORCID: 0009-0009-1469-6559 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Martha, Satyam AU - Martha S AUID- ORCID: 0000-0003-4739-3000 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Maganti, Sri R AU - Maganti SR AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Haritha, K AU - Haritha K AUID- ORCID: 0000-0003-3968-9987 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Yaramala, Harshitha AU - Yaramala H AUID- ORCID: 0009-0002-3172-2092 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. LA - eng PT - Journal Article DEP - 20260302 PL - India TA - Int J Clin Pediatr Dent JT - International journal of clinical pediatric dentistry JID - 101585405 PMC - PMC13280508 OTO - NOTNLM OT - Adolescent behavior OT - Cross-sectional study OT - Junk food OT - Schoolchildren OT - Strengths and Difficulties Questionnaire COIS- Source of support: Nil Conflict of interest: NoneConflict of interest: None EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/04/01 CRDT- 2026/06/22 07:23 PHST- 2025/06/21 00:00 [received] PHST- 2025/07/21 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 07:23 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.5005/jp-journals-10005-3474 [doi] PST - ppublish SO - Int J Clin Pediatr Dent. 2026 Mar;19(3):318-323. doi: 10.5005/jp-journals-10005-3474. Epub 2026 Mar 2. PMID- 42327899 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Recombinant human IGF-1 alleviates dyslipidemia induced by lactational maternal dietary restriction. PG - 1829936 LID - 10.3389/fped.2026.1829936 [doi] LID - 1829936 AB - BACKGROUND: Extrauterine growth restriction (EUGR) critically impacts preterm infants, often due to nutritional deficiency. Lactational protein restriction can disrupt offspring glucose/lipid metabolism by altering gene expression and increasing branched-chain amino acid catabolism. OBJECTIVE: This study aimed to investigate the effects of postpartum maternal dietary restriction (MDR) on growth and lipid metabolism in Sprague-Dawley (SD) rat offspring, and to explore the underlying mechanisms through Agilent microarray-based transcriptomic analysis. METHODS: An EUGR rat model was established by maternal dietary restriction. Body weight, body length, serum insulin-like growth factor-1 (IGF-1), and lipid profiles were monitored from postnatal day 1 to day 21. To evaluate therapeutic effects, a separate cohort of EUGR pups received recombinant human IGF-1 (rhIGF-1) or PBS. Liver transcriptomic analysis was conducted to identify differentially expressed genes. Based on transcriptomic results, lipoprotein lipase (LPL) was overexpressed in HepG2 cells for in vitro functional validation. RESULTS: At 3 weeks of age, EUGR pups showed significantly lower body weight and length than controls (p < 0.01). Serum triglycerides (TG) were reduced in EUGR rats (p < 0.05), whereas total cholesterol and HDL-C were elevated. rhIGF-1 treatment did not improve growth, but significantly reduced HDL-C compared with PBS. Liver transcriptomics revealed altered expression of lipid-metabolism genes in EUGR animals; notably, LPL expression was increased. In HepG2 cells, LPL overexpression significantly downregulated the lipogenic genes ACACA and SCD (p < 0.01). CONCLUSION: Maternal dietary restriction induces EUGR in rats, characterized by growth impairment and dyslipidemia. rhIGF-1 treatment failed to improve growth but modulated HDL-C levels. Liver transcriptomics in EUGR animals show upregulation of LPL, and in vitro experiments demonstrate that LPL can downregulate ACACA and SCD, suggesting that the LPL/ACACA/SCD pathway may underlie the observed triglyceride alterations in EUGR. CI - (c) 2026 Liu, Ma, Cui and Feng. FAU - Liu, Xin AU - Liu X AD - Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China. AD - Neonatal Intensive Care Unit, Department of Pediatrics, Peking University First Hospital, Beijing, China. FAU - Ma, Yuanyuan AU - Ma Y AD - Laboratory of Animal Facility, Peking University First Hospital, Beijing, China. FAU - Cui, Hong AU - Cui H AD - Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China. FAU - Feng, Qi AU - Feng Q AD - Neonatal Intensive Care Unit, Department of Pediatrics, Peking University First Hospital, Beijing, China. LA - eng PT - Journal Article DEP - 20260604 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13275451 OTO - NOTNLM OT - IGF-1 OT - extrauterine growth restriction OT - lactational dietary restriction OT - lipid metabolism OT - rat animal model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 13:43 PMCR- 2026/06/04 CRDT- 2026/06/22 07:20 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/22 13:43 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 07:20 [entrez] PHST- 2026/06/04 00:00 [pmc-release] AID - 10.3389/fped.2026.1829936 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 4;14:1829936. doi: 10.3389/fped.2026.1829936. eCollection 2026. PMID- 42327482 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Shear Wave Elastography in Children: Normative Values and the Impact of Healthy Habits in a Cross-Sectional Study. PG - e72653 LID - 10.1002/hsr2.72653 [doi] LID - e72653 AB - OBJECTIVES: Biomechanical properties of the musculoskeletal system are important to understand muscle function, but they are difficult to assess noninvasively. Shear wave elastography (SWE) allows objective quantification of muscle elasticity. However, normative data and the influence of lifestyle habits on muscle elasticity in children remain unclear, particularly across multiple upper and lower limb muscles and in relation to modifiable healthy behaviors. The main objective was to assess muscle elasticity at rest and during maximum passive stretching (MPS) in children using SWE, and to address existing gaps by evaluating multiple muscles from both limbs, as well as to evaluate the influence of lifestyle factors, with particular attention to healthy habits. DESIGN AND METHODS: SWE was used to measure the elasticity of the biceps brachii, pronator teres, adductor longus, lateral gastrocnemius, and soleus in 44 typically developing children (mean age 8.9 years; range 3-14 years; 27 females). Measurements were taken at rest and MPS. Data included anthropometry, physical fitness, Mediterranean diet adherence, moderate-to-vigorous physical activity (MVPA), and sleep duration, allowing the exploration of lifestyle-related determinants of muscle elasticity. RESULTS: Reliability estimates exceeded 0.91, indicating excellent consistency. SWE values increased with higher Mediterranean adherence during MPS in all muscles, while at rest, an inverse relationship appeared in biceps and pronator teres. Sleep time was negatively associated with SWE at rest and positively adductor longus during MPS. MVPA showed some associations without consistent patterns. CONCLUSIONS: SWE is a reliable and objective technique to evaluate muscle elasticity in typically developing children. By providing multi-muscle reference data from both upper and lower limbs and demonstrating associations with diet and sleep, this study extends current pediatric SWE literature beyond feasibility and reliability. These findings suggest that SWE could help quantify the physiological impact of healthy habits on muscle properties during childhood. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Casellas-Vidal, Dolors AU - Casellas-Vidal D AUID- ORCID: 0000-0001-9560-6758 AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group [Girona Biomedical Research Institute]-IDIBGI Institute of Health Assistance (IAS), Parc Hospitalari Marti i Julia Girona Spain. FAU - Font-Llado, Raquel AU - Font-Llado R AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. AD - Research Group of Culture and Education, Institute of Educational Research University of Girona Girona Spain. FAU - Osiniri, Ines AU - Osiniri I AD - Servei de Pediatria, Clinica Bofill Girona Spain. FAU - Camos-Carreras, Maria AU - Camos-Carreras M AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group [Girona Biomedical Research Institute]-IDIBGI Institute of Health Assistance (IAS), Parc Hospitalari Marti i Julia Girona Spain. FAU - Ruiz-Eizmendi, Aintzane AU - Ruiz-Eizmendi A AD - Servei de Rehabilitacio Hospital Universitari Doctor Josep Trueta Girona Spain. FAU - Serrano-Ferrer, Juan AU - Serrano-Ferrer J AUID- ORCID: 0009-0001-6080-2772 AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. FAU - Casellas, Joaquim AU - Casellas J AD - Departament de Ciencia Animal i dels Aliments Universitat Autonoma de Barcelona Bellaterra Spain. FAU - Lopez-Bermejo, Abel AU - Lopez-Bermejo A AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Pediatric Endocrinology Group Girona Biomedical Research Institute (IDIBGI) Salt Spain. FAU - Prats-Puig, Anna AU - Prats-Puig A AUID- ORCID: 0000-0002-5253-3808 AD - Research Group of Health and Health Care, Nursing Department University of Girona Girona Spain. LA - eng PT - Journal Article DEP - 20260619 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13281414 OTO - NOTNLM OT - children OT - healthy habits OT - lifestyle factors OT - muscle elasticity OT - shear wave elastography COIS- The authors declare no conflicts of interest. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 13:43 PMCR- 2026/06/19 CRDT- 2026/06/22 07:15 PHST- 2025/11/13 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/06/22 13:43 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 07:15 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - HSR272653 [pii] AID - 10.1002/hsr2.72653 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 19;9(6):e72653. doi: 10.1002/hsr2.72653. eCollection 2026 Jun. PMID- 42327477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Psychometric Properties of the Participation Motivation Questionnaire Among Hungarian Female Students. PG - e72696 LID - 10.1002/hsr2.72696 [doi] LID - e72696 AB - BACKGROUND AND AIM: Based on the self-determination theory (SDT), this study primarily aimed to examine the reliability and validity of the Hungarian version of the Participation Motivation Questionnaire (PMQ) among 13-15-year-old female students, and secondarily to describe their motivational profiles and the relationships between motives and physical activity level. METHODS: Three hundred twenty-five female students (mean age = 14.07; SD = 0.87) from nine different schools-wealthy, moderate, and lower income- were randomly sampled from Budapest and its suburbs. Exploratory Factor Analysis was used with the maximum likelihood extraction method and varimax rotation. To establish construct validity, Confirmatory Factor Analysis was conducted. Internal consistency of the questionnaire and its subscales was assessed using Cronbach's alpha. RESULTS: A 27‑item, six-factor solution emerged, partially differing from the original eight-factor structure, and showed acceptable internal consistency (alpha = 0.73-0.84). Associations between motivational factors and sociodemographic characteristics (age, socioeconomic status, urban-rural residence) and physical activity level revealed significant effects of sociodemographic factors on motivation. Fitness emerged as the only motivational factor showing a strong, direct relationship with adolescents' physical activity level. In terms of SDT, intrinsic‑oriented, health‑ and mastery‑related reasons appeared more important than ego‑related and extrinsic reasons for encouraging female students to be physically active. Given the cross-sectional design and the urban-skewed sample, these subgroup findings should be interpreted with caution and considered as a means of generating hypotheses. CONCLUSION: In conclusion, the Hungarian version of the PMQ appears suitable for assessing participation motives among female students in school and sport-related settings and may support educators and practitioners in better understanding motivational patterns when planning and evaluating physical activity programmes. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Ghazvini, Narges AU - Ghazvini N AUID- ORCID: 0000-0001-7335-3948 AD - Doctoral School, Hungarian University of Sports Science Budapest Hungary. AD - Department of Pedagogy Hungarian University of Sports Science Budapest Hungary. FAU - Hamar, Pal AU - Hamar P AUID- ORCID: 0009-0008-8651-3013 AD - Department of Pedagogy Hungarian University of Sports Science Budapest Hungary. AD - Sapientia Hungarian University of Transylvania Sf. Gheorghe Romania. AD - Ludovika University of Public Service Budapest Hungary. FAU - Takacs, Johanna AU - Takacs J AUID- ORCID: 0000-0002-8709-8826 AD - Department of Social Sciences Semmelweis University Budapest Hungary. FAU - Petridis, Leonidas AU - Petridis L AUID- ORCID: 0000-0002-8534-7550 AD - Research Center for Sport Physiology Hungarian University of Sport Science Budapest Hungary. FAU - Soos, Istvan AU - Soos I AUID- ORCID: 0000-0002-5511-9477 AD - Department of Pedagogy Hungarian University of Sports Science Budapest Hungary. LA - eng PT - Journal Article DEP - 20260620 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13282752 OTO - NOTNLM OT - Hungarian female students OT - participation motivation questionnaire OT - physical activity OT - self-determination theory OT - sociodemographic factors COIS- The authors declare no conflicts of interest. EDAT- 2026/06/22 13:44 MHDA- 2026/06/22 13:45 PMCR- 2026/06/20 CRDT- 2026/06/22 07:15 PHST- 2025/11/18 00:00 [received] PHST- 2026/03/09 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/22 13:45 [medline] PHST- 2026/06/22 13:44 [pubmed] PHST- 2026/06/22 07:15 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - HSR272696 [pii] AID - 10.1002/hsr2.72696 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 20;9(6):e72696. doi: 10.1002/hsr2.72696. eCollection 2026 Jun. PMID- 42326953 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Cross-cultural adaptation and validation of the health-promoting lifestyle profile II for Mongolian university students. PG - 1846655 LID - 10.3389/fpubh.2026.1846655 [doi] LID - 1846655 AB - BACKGROUND: University lifestyle can have lasting effects on students' health, yet culturally validated instruments to examine health-promoting lifestyles are lacking in Mongolia. This study aimed to adapt the Health-Promoting Lifestyle Profile II (HPLP-II) and to assess the validity and reliability of its Mongolian version among students in Ulaanbaatar. METHODS: A cross-sectional study was conducted with 827 undergraduate students from three universities in Ulaanbaatar, Mongolia. The instrument was translated from English into Mongolian using standard forward- and backward-translation procedures. The final version retained six dimensions and 51 items. Construct validity was assessed using confirmatory factor analysis for a six-component structure, and internal consistency was evaluated using Cronbach's alpha and McDonald's omega. FINDINGS: Confirmatory factor analysis indicated a good fit for the six-factor structure (chi (2) = 14233.03; df = 1,275; p < 0.001; CFI = 0.95, GFI = 0.95, TLI = 0.95, SRMR = 0.065, and RMSEA = 0.031). The overall HPLP-II demonstrated high internal consistency (omega = 0.92, alpha = 0.91). However, the nutrition dimension exhibited the lowest reliability and factor loadings, suggesting revision for future studies. CONCLUSION: The Mongolian version of the HPLP-II demonstrated acceptable reliability and construct validity, supporting the use of a six-dimensional, 51-item instrument to assess health-promoting lifestyles among Mongolian university students. These findings provide a foundation for future health-promotion interventions in Mongolian university settings. CI - Copyright (c) 2026 Uitumen and Tarko. FAU - Uitumen, Erdenezul AU - Uitumen E AD - Doctoral School of Education, Faculty of Humanities and Social Sciences, University of Szeged, Szeged, Hungary. AD - Department of Nutrition, School of Public Health, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia. FAU - Tarko, Klara AU - Tarko K AD - Juhasz Gyula Faculty of Education, Institute of Applied Health Sciences and Environmental Education, University of Szeged, Szeged, Hungary. LA - eng PT - Journal Article PT - Validation Study DEP - 20260605 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/statistics & numerical data/psychology MH - Universities MH - Mongolia MH - Female MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Male MH - Young Adult MH - Surveys and Questionnaires/standards MH - *Health Promotion MH - *Healthy Lifestyle MH - *Cross-Cultural Comparison MH - Adult MH - *Life Style MH - Psychometrics MH - Adolescent PMC - PMC13279628 OTO - NOTNLM OT - Mongolia OT - health-promoting lifestyle OT - reliability OT - university students OT - validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/06/05 CRDT- 2026/06/22 07:09 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 07:09 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1846655 [doi] PST - epublish SO - Front Public Health. 2026 Jun 5;14:1846655. doi: 10.3389/fpubh.2026.1846655. eCollection 2026. PMID- 42326410 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - Human milk microbiota: origins, determinants, and roles in maternal-infant microbial transmission and infant microbiome assembly. PG - 1790225 LID - 10.3389/fmicb.2026.1790225 [doi] LID - 1790225 AB - Human milk is a complex and dynamic biological fluid that provides essential nutrients and harbors a diverse, functional microbiota, playing a critical role in infant microbial colonization and early life development. The milk microbiota is derived from multiple maternal and environmental sources, including the maternal gut via the entero-mammary pathway, the mammary and skin microbiota, infant oral microbes through retrograde flow, and environmental exposures. Its composition is influenced by a range of factors, such as maternal metabolic and health status, diet, and antibiotic use, as well as delivery mode, lactation stage, infant characteristics, and geographic context. Human milk contributes to the establishment of oral, airway, and gut microbial communities by transferring key taxa such as Bifidobacterium and Lactobacillus, which are commonly detected in milk; however, direct evidence of specific strains establishing in the infant gut remains limited. Breastfeeding may partially compensate for microbiome deficits in cesarean-delivered, preterm, and antibiotic-exposed infants, supporting protection against infections, allergies, asthma, obesity, and other health outcomes. Translational strategies may help modulate the milk microbiota. These include maternal probiotic or prebiotic supplementation, dietary optimization, and approaches targeting microbiota or bioactive milk components. Such strategies offer feasible and cost-effective means to support healthy infant microbiome development. However, methodological constraints including low-biomass contamination, sequencing biases, and limited strain-level resolution remain significant challenges in accurately characterizing the human milk microbiota. Despite substantial advances, the relative contributions of distinct transmission routes, the persistence of maternal strains, and the efficacy of targeted maternal interventions remain incompletely understood. Addressing these gaps will be essential for refining strategies to promote healthy microbiome maturation and improve lifelong health outcomes. CI - Copyright (c) 2026 Ma, Peng, Qin, Cai, Tan and Gao. FAU - Ma, Guangyu AU - Ma G AD - Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Peng, Leixi AU - Peng L AD - Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Qin, Lang AU - Qin L AD - Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Cai, Rui AU - Cai R AD - Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Tan, Xi AU - Tan X AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Gao, Rui AU - Gao R AD - Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. LA - eng PT - Journal Article PT - Review DEP - 20260605 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC13278873 OTO - NOTNLM OT - breastfeeding OT - dietary modifications OT - human milk microbiota OT - infant healthy OT - infant microbiota OT - maternal-infant microbial transfer OT - prebiotics OT - probiotics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 13:43 PMCR- 2026/06/05 CRDT- 2026/06/22 07:05 PHST- 2026/01/17 00:00 [received] PHST- 2026/05/03 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/22 13:43 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 07:05 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1790225 [doi] PST - epublish SO - Front Microbiol. 2026 Jun 5;17:1790225. doi: 10.3389/fmicb.2026.1790225. eCollection 2026. PMID- 42326162 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - A Retrospective Comparison of Transcutaneous and End-Tidal Carbon Dioxide Monitoring in Pediatric Polysomnography. PG - e109308 LID - 10.7759/cureus.109308 [doi] LID - e109308 AB - Background Accurate monitoring of carbon dioxide (CO(2)) is important in pediatric polysomnography (PSG), particularly for identifying nocturnal hypoventilation, a condition with significant clinical consequences in children, especially those with neuromuscular or pulmonary disorders. Two primary modalities are available for non-invasive CO(2) estimation: end-tidal CO(2) (EtCO(2)) and transcutaneous CO(2) (TcCO(2)). While both are widely used, their diagnostic equivalence remains unclear. This study aimed to address the clinical question of whether TcCO(2) and EtCO(2) measurements in pediatric PSG can replace each other. Methods A single-center retrospective study was conducted by including pediatric patients who underwent PSG with concurrent EtCO(2) and TcCO(2) monitoring. For each patient, mean, maximum, and minimum CO(2) values, as well as sleep duration with values exceeding 50 mmHg, were extracted and analyzed between the two modalities. The diagnostic rates of nocturnal hypoventilation as defined by the American Academy of Sleep Medicine (AASM) Manual were also compared. Results Among 127 children (median age 11 years, interquartile range age eight to 14), based on the Bland-Altman analysis, a positive mean bias was observed in all three comparisons, suggesting that EtCO(2) measurements were systematically lower than TcCO(2). Wide 95% limits of agreement in all TcCO(2) and EtCO(2) measurements were observed. A weakly positive correlation but with marginal statistical significance was noted between mean TcCO(2) and EtCO(2) values (rs=0.173, p=0.052). Maximum TcCO(2) and EtCO(2) values were also only weakly correlated (rs=0.288, p=0.001). The median of mean TcCO(2) was significantly higher than that of mean EtCO(2): 42.95 mmHg vs. 39.00 mmHg, respectively (Z = -8.06, p < 0.001). The median of maximum TcCO(2) was also significantly higher than that of maximum EtCO(2) values: 47.40 mmHg vs. 44.00 mmHg, respectively (Z = -7.50, p < 0.001). However, no statistically significant difference was observed for the corresponding minimum values (36.60 mmHg vs. 35.00 mmHg; Z = -1.94, p = 0.052). Ten out of 127 (7.9%) patients were diagnosed with hypoventilation by TcCO(2) measurement, none of whom could be diagnosed based on EtCO(2) measurement. Subgroup analysis by age, sex, obstructive sleep apnea (OSA) severity, obesity, craniofacial abnormalities, tonsillar hypertrophy, and syndromic diagnosis yielded no significantly different findings. Conclusions Our study suggested that EtCO(2) and TcCO(2) measurements in pediatric PSG may not be interchangeable, given the observed suboptimal agreement between the two modalities, i.e., the tendency for TcCO(2) values to be higher than EtCO(2), and the weak and mostly statistically insignificant correlation observed for CO(2) measurements. However, in the absence of arterial blood gas (ABG) as a reference standard, it was not possible to determine which modality more accurately reflects true arterial CO(2) levels or was more reliable for identifying nocturnal hypoventilation. CI - Copyright (c) 2026, Tsui et al. FAU - Tsui, Tak Kong AU - Tsui TK AD - Pediatrics, Pamela Youde Nethersole Eastern Hospital, Hong Kong, CHN. LA - eng PT - Journal Article DEP - 20260520 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13282146 OTO - NOTNLM OT - end-tidal co2 monitoring OT - nocturnal hypoventilation OT - obstructive sleep apnoea OT - paedatrics OT - polysomnography OT - trancutaneous co2 monitoring COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Hospital Authority Central Institutional Review Board issued approval PAED-2026-024. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/05/20 CRDT- 2026/06/22 07:03 PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 07:03 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.7759/cureus.109308 [doi] PST - epublish SO - Cureus. 2026 May 20;18(5):e109308. doi: 10.7759/cureus.109308. eCollection 2026 May. PMID- 42325832 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260813 IS - 3006-6514 (Electronic) IS - 3006-6506 (Print) IS - 3006-6506 (Linking) VI - 3 IP - 2 DP - 2026 TI - Harnessing Artificial Intelligence for Hypothesis Generation in Childhood Asthma: Insights from NHANES. LID - 10003 [pii] LID - 10.70322/jrbtm.2026.10003 [doi] AB - Although large language models (LLMs) have undergone substantial development, their applicability to epidemiological research has not been sufficiently examined. This study aims to develop and evaluate an LLM-based framework for hypothesis generation and testing, demonstrating its application in childhood asthma in the National Health and Nutrition Examination Survey (NHANES). Pilot study was conducted to explore factors associated with childhood asthma in the 2001-2020 NHANES cycles. A modular agent system was developed, including Database Query, Statistic, Paper Search, and Paper Download tools, along with two LLM models (Key Generator and Hypothesis Tester). Multivariable logistic regression was used to test for the association between each variable and current asthma, generating a tentative affirmative claim. The Key Generator module produced keywords for literature search, the Paper Search and Paper Download tools queried PubMed and retrieved relevant studies, and the Hypothesis Tester module synthesized evidence and determined the support for claims for each variable. Keywords and conclusions were reviewed by researchers and validated using multiple LLMs (ChatGPT, DeepSeek, and Gemini) to ensure consistency and robustness. 25,839 children with (n = 2928) and without (n = 22,911) current asthma, and 10,359 variables were included in the multivariable analysis, which yielded 100 variables associated with asthma. Of these, 21 were directly related to asthma (supporting published studies), 43 were indirectly related to asthma (based on background knowledge, though not explicitly discussed in the available publications), and 34 were unrelated to asthma. Two variables were excluded due to a lack of discriminative keywords. This study demonstrates the effectiveness of LLM-based models for generating and testing hypotheses about childhood asthma. FAU - Liu, Jing AU - Liu J AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Han, Yueh-Ying AU - Han YY AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Ye, Xiangyu AU - Ye X AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Rosser, Franziska J AU - Rosser FJ AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Gaietto, Kristina M AU - Gaietto KM AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Zhao, Chongyue AU - Zhao C AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Chen, Wei AU - Chen W AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. AD - Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. FAU - Celedon, Juan C AU - Celedon JC AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. LA - eng GR - R01 HL152475/HL/NHLBI NIH HHS/United States GR - R01 HL168539/HL/NHLBI NIH HHS/United States GR - T32 HL129949/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260428 PL - China TA - J Respir Biol Transl Med JT - Journal of respiratory biology and translational medicine JID - 9918786787606676 PMC - PMC13278482 MID - NIHMS2180431 OTO - NOTNLM OT - Artificial intelligence OT - Asthma OT - Children OT - Risk factors COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/06/19 CRDT- 2026/06/22 07:00 PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 07:00 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10003 [pii] AID - 10.70322/jrbtm.2026.10003 [doi] PST - ppublish SO - J Respir Biol Transl Med. 2026;3(2):10003. doi: 10.70322/jrbtm.2026.10003. Epub 2026 Apr 28. PMID- 42325730 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Dietary assessment tools for children and adolescents in Latin America: a scoping review. PG - e46 LID - 10.1017/jns.2026.10116 [doi] LID - e46 AB - Accurately assessing dietary intake in children and adolescents is essential for understanding dietary patterns and informing public health strategies. In Latin America, rapid nutrition transitions and increasing childhood obesity highlight the need for culturally appropriate, validated dietary assessment tools (DATs). However, methodological challenges and limited regional data hinder effective dietary surveillance. This scoping review identified and characterised DATs used among children and adolescents (5-18 years) in Latin America, examining tool types, features, validation and regional coverage. Following Joanna Briggs Institute and PRISMA-ScR guidelines, comprehensive searches were conducted in EMBASE, Web of Science, PubMed, and LILACS (April 2024) in English, Spanish, and Portuguese. Eligible studies included original research developing, validating, or applying DATs in Latin American populations. Of 13,946 records screened, 105 reports met the inclusion criteria. Brazil and Mexico contributed the most studies, while six countries (Paraguay, El Salvador, Nicaragua, Panama, Honduras, and Belize) had none. Forty-three DATs were identified, 77% of which were food frequency questionnaires (FFQs). Half targeted adolescents, 39% children, and 11% both groups. Most were interviewer-administered (58%) and applied in person (49%), with only 19% conducted online, reflecting regional digital limitations. Validation was reported for 70% of tools, primarily against 24 HR. The DAT landscape in Latin America remains dominated by FFQs and traditional administration methods, with limited use of digital platforms. Developing age-appropriate, validated and culturally adapted digital DATs is essential to strengthen dietary surveillance and guide effective nutrition policies across the region. CI - (c) The Author(s) 2026. FAU - Vidal, Milca AU - Vidal M AUID- ORCID: 0009-0002-9328-8981 AD - Food Science and Nutrition, University of Leeds Faculty of Environment, UK. ROR: https://ror.org/024mrxd33 FAU - Iqbal, Muhammed AU - Iqbal M AD - Food Science and Nutrition, University of Leeds Faculty of Environment, UK. ROR: https://ror.org/024mrxd33 AD - Clinical nutrition, Politeknik Negeri Jember, Indonesia. FAU - Cade, Janet AU - Cade J AD - Nutrition Epidemiology Group, University of Leeds, UK. FAU - Nykjaer, Camilla AU - Nykjaer C AD - School of Biomedical Sciences, University of Leeds Faculty of Biological Sciences, UK. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260617 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Child MH - Adolescent MH - Latin America MH - *Nutrition Assessment MH - Child, Preschool MH - *Diet MH - *Diet Surveys/methods PMC - PMC13279971 OTO - NOTNLM OT - Adolescents OT - Children OT - Dietary assessment tool OT - Latin America OT - Scoping Review COIS- The author(s) declare none. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 19:00 PMCR- 2026/06/17 CRDT- 2026/06/22 06:59 PHST- 2025/11/10 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/22 19:00 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 06:59 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - S2048679026101165 [pii] AID - 10.1017/jns.2026.10116 [doi] PST - epublish SO - J Nutr Sci. 2026 Jun 17;15:e46. doi: 10.1017/jns.2026.10116. eCollection 2026. PMID- 42325327 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Family sports environment and emotional regulation in Chinese adolescents: the mediating roles of sports lifestyle and parent-child interaction. PG - 1812203 LID - 10.3389/fpsyg.2026.1812203 [doi] LID - 1812203 AB - Against the backdrop of increasingly prominent mental health issues among adolescents, insufficient development of the family sports environment, a key external factor associated with emotional regulation, has emerged as a critical but often overlooked determinant of psychological stability and resilience among Chinese youth. In particular, the absence of an active sports lifestyle and structured parent-child interaction patterns may be associated with impaired emotional regulation processes, highlighting the need to examine the associational pathways. OBJECTIVE: This study aimed to investigate the association between the family sports environment and emotional regulation abilities among Chinese adolescents and to explore the serial indirect associations of sports; lifestyle and parent-child relationship within a theoretically informed mediation model. METHODS: A cluster sampling survey was conducted among 750 Chinese adolescents. Data were collected using the Family Sports Environment Scale, the Adolescent Emotional Regulation Scale, the Sports Lifestyle Scale, and the Parent-Child Relationship Scale. All variables were measured at a single time point using self-report questionnaires. RESULTS: (1) No statistically significant differences were observed across gender or age in family sports environment, emotional regulation, sports lifestyle, or parent-child relationship (p > 0.05); (2) The family sports environment was significantly and positively associated with emotional regulation (r = 0.698, p < 0.001). Regression analyses indicated that the total effect of family sports environment on emotional regulation was significant (unstandardized coefficient, B = 0.292; t = 26.811, p < 0.001). while the direct effect also remained significant (standardized coefficient,beta = 0.207; t = 3.829, p < 0.001). In addition, the family sports environment was significantly associated with variations in sports lifestyle (B = 1.957, t = 37.969, p < 0.001) and parent-child relationship (B = 0.292, t = 8.445, p < 0.001). Sports lifestyle was significantly associated with variations in parent-child relationship (beta = 0.226, t = 15.931, p < 0.001) and emotional regulation (beta = 0.203, t = 8.400, p < 0.001). Moreover, the parent-child relationship was significantly associated with variations in emotional regulation (beta = 0.524, t = 9.175, p < 0.001); (3) Sports lifestyle and parent-child relationship both demonstrated significant mediating associations in the relationship between family sports environment and adolescent emotional regulation, consistent with a serial mediation model of associations. CONCLUSION: The family sports environment was significantly associated with healthier sports lifestyles among Chinese adolescents and more positive parent-child relationships, and was also indirectly associated with emotional regulation abilities through the sequential mediating effects of these two factors. Sports lifestyles and parent-child relationships function as key intermediary pathways linking the family sports environment to adolescents' emotional regulation, thereby providing a theoretically informed explanation of the observed associative pathways. From a practical perspective, these findings suggest that optimizing the family sports environment, encouraging parent-child engagement in physical activities, and fostering regular physical activity habits among adolescents may be supportive contextual factors for improving emotional regulation and supporting mental health development. Such strategies may also provide valuable implications for family-based sports guidance and adolescent mental health support practices. However, this study is subject to limitations related to sample representativeness and cross-sectional research design. Future research is encouraged to employ longitudinal designs and incorporate more comprehensive family-context variables to further examine and validate these associations. CI - Copyright (c) 2026 Zhou, Liu and Xiang. FAU - Zhou, Zhixing AU - Zhou Z AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Liu, Weijian AU - Liu W AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Xiang, Jun AU - Xiang J AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. LA - eng PT - Journal Article DEP - 20260604 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13275267 OTO - NOTNLM OT - adolescents OT - emotional regulation OT - family sports environment OT - mediating effect OT - mental health OT - parent-child relationship OT - psychological resilience OT - sports lifestyle COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 13:43 PMCR- 2026/06/04 CRDT- 2026/06/22 06:56 PHST- 2026/02/16 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/22 13:43 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 06:56 [entrez] PHST- 2026/06/04 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1812203 [doi] PST - epublish SO - Front Psychol. 2026 Jun 4;17:1812203. doi: 10.3389/fpsyg.2026.1812203. eCollection 2026. PMID- 42325257 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260926 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 14 DP - 2025 TI - Gender and Narrative Writing in Elementary Schools: A Qualitative Study Supporting Inclusive Education. PG - 1317 LID - 10.12688/f1000research.171604.2 [doi] LID - 1317 AB - BACKGROUND: This study investigates gender differences in narrative writing among primary school students to promote inclusive education, as narrative writing reflects embedded gender norms that influence literacy development and classroom equity. By examining these differences, this study aims to highlight how gender stereotypes can marginalize certain narrative styles and inform pedagogical strategies for Indonesian schools. METHODS: This qualitative case study with quantitative analysis examined 33 handwritten narratives from fifth-grade students (12 boys, 21 girls) and interviews with 10 students. SES data were collected through a parent questionnaire covering education, occupation, and home literacy environment. Two blind raters evaluated the narratives, with moderate inter-rater reliability (Cohen's kappa = 0.434). Thematic analysis was supplemented with t-tests and Pearson correlations to examine gender differences and the relationship between SES and narrative quality. RESULTS: The results showed that female students excelled notably in organization (mean score 18,4 vs. 15,1 for males), grammar (9,95 vs. 8,15), and writing conventions (2,7 vs. 2,2), indicating greater coherence, grammatical accuracy, and technical precision in their narratives. In contrast, male students scored slightly higher on content (26 vs. 25,3), driven by a marginally higher focus on characterization, though females led in plot complexity and setting detail. Language scores were comparable between genders. The overall final narrative score favored females (68,95 vs. 63,95). Correlation analysis revealed significant relationships between maternal education, home literacy environment, and narrative quality. CONCLUSIONS: Gender stereotypes shape literacy practices and may perpetuate educational inequalities. The study recommends gender-sensitive rubrics, cross-gender writing exercises, and teacher training to support inclusive education that validates diverse student voices. CI - Copyright: (c) 2026 Wulan Anggraeni S et al. FAU - Wulan Anggraeni, Sri AU - Wulan Anggraeni S AUID- ORCID: 0009-0006-4178-7403 AD - Faculty of Education Sciences, Universitas Pendidikan Indonesia Fakultas Ilmu Pendidikan, Bandung, West Java, 40154, Indonesia. AD - Faculty of Teacher Training and Education, Universitas Buana Perjuangan Karawang, Karawang Regency, West Java, 41361, Indonesia. FAU - Sunendar, Dadang AU - Sunendar D AD - Faculty of Language and Literature Education, Universitas Pendidikan Indonesia Fakultas Pendidikan Bahasa dan Seni, Bandung, West Java, 40154, Indonesia. FAU - Cahyani, Isah AU - Cahyani I AD - Faculty of Language and Literature Education, Universitas Pendidikan Indonesia Fakultas Pendidikan Bahasa dan Seni, Bandung, West Java, 40154, Indonesia. LA - eng SI - figshare/10.6084/m9.figshare.31697821 PT - Journal Article DEP - 20260502 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Humans MH - Female MH - *Writing MH - Male MH - *Schools MH - Child MH - *Narration MH - Qualitative Research MH - Students MH - Sex Factors PMC - PMC13282602 OTO - NOTNLM OT - elementary education OT - gender and literacy OT - gender stereotypes OT - inclusive education OT - narrative writing COIS- No competing interests were disclosed. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/05/02 CRDT- 2026/06/22 06:55 PHST- 2026/03/14 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 06:55 [entrez] PHST- 2026/05/02 00:00 [pmc-release] AID - 10.12688/f1000research.171604.2 [doi] PST - epublish SO - F1000Res. 2026 May 2;14:1317. doi: 10.12688/f1000research.171604.2. eCollection 2025. PMID- 42324999 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260922 IS - 1524-4539 (Electronic) IS - 0009-7322 (Print) IS - 0009-7322 (Linking) VI - 154 IP - 7 DP - 2026 Aug 18 TI - Consumption of Fructose-Containing Food and Beverage Sources in Childhood Through to Adulthood and Risk of Hypertension: A Prospective Cohort Study. PG - 612-623 LID - 10.1161/CIRCULATIONAHA.125.077666 [doi] AB - BACKGROUND: High intakes of fructose-containing sugars among children and adolescents is implicated in obesity and related comorbidities, including hypertension. However, sugar-sweetened beverages (SSBs), fruit juices, and whole fruit have different nutritional profiles and matrices, which may confer different effects on blood pressure. METHODS: GUTS (Growing Up Today Study) is a longitudinal cohort of 25 749 individuals (55% female) drawn from 2 enrollment waves, GUTS 1 (n=16 875; baseline 1996) and GUTS II (n=10 918; baseline 2004), followed up prospectively through 2021 (mean age at enrollment, 12 years; mean age at end of follow-up, 36 years). Participants provided updated information on lifestyle, health status, and habitual diet through validated food frequency questionnaires every 1 to 4 years. We conducted multivariable adjusted Cox proportional hazards regression models to estimate the associations of total fructose and SSB, fruit juice, and whole fruit intake (cumulative averages) with incident hypertension (hazard ratios [HRs] and 95% CIs), adjusting for major diet and lifestyle factors. We also modeled substitutions of SSBs or fruit juice with whole fruit, milk, and water. RESULTS: During up to 25 years of follow-up, 1625 participants (6.3%) reported a hypertension diagnosis. Total fructose intake was not associated with incident hypertension (highest versus lowest quintile HR, 1.07 [95% CI, 0.92, 1.25]; P(trend)<0.001). However, participants with the highest intake of SSBs (>/=2 servings/d versus <3 servings/week) and fruit juice (>/=1.5 servings/d versus <1 serving/wk) had a higher risk of hypertension (HR, 1.52 [95% CI, 1.27, 1.83]; P(trend)<0.001 and HR, 1.35 [95% CI, 1.06, 1.71]; P(trend)=0.018, respectively). In contrast, whole fruit was not associated with hypertension (highest versus lowest category HR, 0.79 [95% CI, 0.59, 1.05]; P(trend)=0.08). Replacing 1 serving/d of SSB with milk, water, or whole fruit was associated with a 13% (95% CI, 5%, 20%), 9% (95% CI, 3%, 15%), and 22% (95% CI, 11%, 31%) lower risk of hypertension, respectively. In addition, replacing fruit juice with whole fruit was associated with a 19% (95% CI, 3%, 32%) lower risk of hypertension. CONCLUSIONS: SSB and fruit juice intakes were positively associated with a higher risk of hypertension independently of overall diet quality, physical activity, and other factors. Our findings support public health guidelines to limit the overconsumption of SSBs and fruit juice starting in childhood to protect against the development of hypertension. FAU - Nguyen, Michelle AU - Nguyen M AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). FAU - AlEssa, Hala B AU - AlEssa HB AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Public Health Practice, College of Public Health, Kuwait University, Kuwait City (H.B.A.). FAU - Glenn, Andrea J AU - Glenn AJ AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Nutrition and Food Studies, New York University, New York City (A.J.G.). FAU - Tobias, Deirdre K AU - Tobias DK AUID- ORCID: 0000-0003-0020-9552 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Medicine, Division of Preventive Medicine (D.K.T.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. FAU - Chavarro, Jorge E AU - Chavarro JE AUID- ORCID: 0000-0002-4436-9630 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Epidemiology (J.E.C., W.C.W., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Medicine, Channing Division of Network Medicine (J.E.C., F.B.H.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. FAU - Willett, Walter C AU - Willett WC AUID- ORCID: 0000-0003-1458-7597 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Epidemiology (J.E.C., W.C.W., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA. FAU - Hu, Frank B AU - Hu FB AUID- ORCID: 0000-0002-8233-6274 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Epidemiology (J.E.C., W.C.W., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Medicine, Channing Division of Network Medicine (J.E.C., F.B.H.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. FAU - Hanley, Anthony J AU - Hanley AJ AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Division of Endocrinology (A.J.H.), University of Toronto, ON Canada. AD - Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada (A.J.H.). FAU - Birken, Catherine S AU - Birken CS AUID- ORCID: 0000-0003-0308-8645 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Department of Paediatrics (C.S.B.), University of Toronto, ON Canada. AD - Department of Medicine, Temerty Faculty of Medicine (C.S.B., J.L.S.), University of Toronto, ON Canada. AD - Child Health Evaluative Sciences, SickKids Research Institute, Toronto, ON, Canada (C.S.B.). FAU - Sievenpiper, John L AU - Sievenpiper JL AUID- ORCID: 0000-0002-3270-5772 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Department of Medicine, Temerty Faculty of Medicine (C.S.B., J.L.S.), University of Toronto, ON Canada. AD - Toronto 3D Knowledge Synthesis & Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, Division of Endocrinology & Metabolism, and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada (J.L.S.). FAU - Malik, Vasanti S AU - Malik VS AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. LA - eng GR - U01 HL145386/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260622 PL - United States TA - Circulation JT - Circulation JID - 0147763 RN - 30237-26-4 (Fructose) SB - IM MH - Humans MH - Female MH - *Fructose/adverse effects/administration & dosage MH - *Hypertension/epidemiology/diagnosis/etiology MH - Child MH - Prospective Studies MH - Male MH - *Sugar-Sweetened Beverages/adverse effects MH - Risk Factors MH - Adolescent MH - *Fruit and Vegetable Juices/adverse effects MH - Adult MH - *Beverages/adverse effects MH - Longitudinal Studies MH - Young Adult MH - Fruit MH - Incidence PMC - PMC13288772 MID - NIHMS2176243 OTO - NOTNLM OT - fructose OT - fruit OT - fruit and vegetable juices OT - hypertension OT - sugar-sweetened beverages COIS- Dr AlEssa is supported by the 2017 Faculty Research grant at the Middle East Initiative, Harvard Kennedy School by the Kuwait Foundation for the Advancement of Sciences, and by the Cardiovascular Health Research Grant 2023 by the Kuwait Heart Foundation. Dr Tobias is funded by the National Institutes of Health/National Institute for National Institute of Diabetes and Digestive and Kidney Diseases for related research. Dr Glenn has received travel support and/or honoraria from the Lawson Centre Nutrition Digital Series (University of Toronto), the Good Food Institute, Vinasoy, and the British Nutrition Society. Dr Hanley has received research grants from the Canadian Institutes of Health Research, Diabetes Canada, the Canadian Foundation for Innovation, the Canada Research Chairs Program, the Canadian Foundation for Innovation, and Dairy Farmers of Canada. Dr Sievenpiper has received research support from the Canadian Foundation for Innovation, Ontario Research Fund, Province of Ontario Ministry of Research and Innovation and Science, Canadian Institutes of Health Research, Diabetes Canada, American Society for Nutrition, National Honey Board (US Department of Agriculture honey "Checkoff" program), Institute for the Advancement of Food and Nutrition Sciences, Pulse Canada, Quaker Oats Center of Excellence, INC International Nut and Dried Fruit Council Foundation, The United Soybean Board (US Department of Agriculture soy "Checkoff" program), Protein Industries Canada (a government of Canada Global Innovation Cluster), Almond Board of California, European Fruit Juice Association, The Tate and Lyle Nutritional Research Fund at the University of Toronto, The Glycemic Control and Cardiovascular Disease in Type 2 Diabetes Fund at the University of Toronto (a fund established by the Alberta Pulse Growers), The Plant Protein Fund at the University of Toronto (a fund that has received contributions from IFF among other donors), The Plant Milk Fund at the University of Toronto (a fund established by the Karuna Foundation through Vegan Grants), and The Nutrition Trialists Network Fund at the University of Toronto (a fund established by donations from the Calorie Control Council, Physicians Committee for Responsible Medicine, and Login5 Foundation). He has received food donations to support randomized controlled trials from the Almond Board of California, California Walnut Commission, Danone, Nutrartis, Soylent, and Dairy Farmers of Canada. He has received travel support, speaker fees, and/or honoraria from FoodMinds LLC, Nestle, Abbott, General Mills, Nutrition Communications, International Food Information Council, Arab Beverage Association, International Sweeteners Association, Calorie Control Council, Phynova, International Stevia Council, Mantra Pharma Inc, Chinese Institute of Food Science and Technology, and Collaborative CME and Research Network. He has or has had ad hoc consulting arrangements with Almond Board of California, Perkins Coie LLP, Tate & Lyle, Ingredion, and Brightseed. He is on the Clinical Practice Guidelines Expert Committees of Diabetes Canada, European Association for the Study of Diabetes, Canadian Cardiovascular Society, and Obesity Canada/Canadian Association of Bariatric Physicians and Surgeons. He serves as an unpaid member of the Board of Trustees of the Institute for the Advancement of Food and Nutrition Sciences. He is a director at large of the Canadian Nutrition Society, founding member of the International Carbohydrate Quality Consortium, Executive Board member of the Diabetes and Nutrition Study Group of the European Association for the Study of Diabetes, and director of the Toronto 3D Knowledge Synthesis and Clinical Trials foundation. His spouse is a former employee of Nestle Health Science and AB InBev. Dr Malik has received funding from the Canada Research Chairs Program; Connaught New Researcher Award, University of Toronto; The Joannah & Brian Lawson Centre for Child Nutrition, University of Toronto; Temerty Faculty of Medicine Pathway Grant, University of Toronto; Canada Foundation for Innovation; Ontario Research Fund, Canadian Institutes of Health Research, National Institutes of Health, and has served as a consultant for the City and County of San Francisco for litigation related to health warning labels on SSBs and on the Robert Wood Johnson Healthy Eating Research Advisory Committee for child beverage guidance. Dr Birken received funding from Canadian Institutes of Health Research, Heart & Stroke Foundation of Canada, Physician Services Inc, The Edwin S.H. Leong Centre for Healthy Children, University of Toronto and Hospital for Sick Children, the Centre for Addiction and Mental Health, Joannah & Brian Lawson Centre for Child Nutrition, University of Toronto, and a Walmart Canada Regional Community Grant, administered through SickKids Foundation. The other authors report no conflicts. EDAT- 2026/06/22 06:45 MHDA- 2026/08/17 17:45 PMCR- 2026/06/24 CRDT- 2026/06/22 05:03 PHST- 2026/08/17 17:45 [medline] PHST- 2026/06/22 06:45 [pubmed] PHST- 2026/06/22 05:03 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1161/CIRCULATIONAHA.125.077666 [doi] PST - ppublish SO - Circulation. 2026 Aug 18;154(7):612-623. doi: 10.1161/CIRCULATIONAHA.125.077666. Epub 2026 Jun 22. PMID- 42324958 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260911 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 83 IP - 3 DP - 2026 Sep TI - Development and validation of the new French ORALQUEST scale for evaluating feeding difficulties in young children. PG - 528-535 LID - 10.1002/jpn3.70491 [doi] AB - OBJECTIVE: Feeding difficulties are common in children with and without somatic conditions. Our objective was to develop a parent-report questionnaire (ORALQUEST) designed to be administered by a professional and to assess feeding difficulties in children aged 9 months to 6 years. METHODS: The questionnaire explores four domains: eating behavior, oral skills, tactile and oral sensitivity, and family environment. A validation study was done in 338 children seen for feeding difficulties (n = 74) or receiving follow-up for conditions at risk for feeding difficulties (n = 264). We assessed the validity and reliability of the tool and we conducted a receiver operating characteristic (ROC) analysis to determine the best total-score cutoff. RESULTS: The final version of the ORALQUEST has 40 items and produces a total score and four sub-scores. Structural validity, internal consistency, and reliability were excellent; convergent validity was good to acceptable but was challenging to assess given the absence of similar tools for comparisons. The optimal total-score cutoff was 27. Among children seen for feeding difficulties, 85% had a total score >/= 27. Total scores above the cutoff were less common than expected in children with chronic conditions (esophageal atresia, 39%; autism spectrum disorder, 42%; complex congenital heart disease, 29%; Robin sequence, 31%; and cleft palate, 18%). CONCLUSION: ORALQUEST for assessing feeding difficulties in young children demonstrated good psychometric properties in children with and without somatic conditions. The investigation by ORALQUEST of four domains may help to determine the best management strategy. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT04133038 (Clinicaltrials.gov) https://clinicaltrials.gov/study/NCT04133038. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Thouvenin, Beatrice AU - Thouvenin B AD - General Paediatric Unit, Necker University Hospital, Paris, France. FAU - Ould-Ammar, Redha AU - Ould-Ammar R AD - Unit of Clinical Research, AP-HP, University Necker Hospital, Paris, France. FAU - Ouss, Lisa AU - Ouss L AD - Child Psychiatry Unit, Necker University Hospital, Paris, France. FAU - Gavelle, Pascale AU - Gavelle P AD - Maxillo Facial Surgery Unit, Necker University Hospital, Paris, France. FAU - Disnan, Giulia AU - Disnan G AD - Paediatric Surgery, Necker University Hospital, Paris, France. FAU - Royer, Aurelie AU - Royer A AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. FAU - Vegas, Nancy AU - Vegas N AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. AD - Paris Cite University, Paris, France. FAU - Fraysseix, Catherine du AU - Fraysseix CD AD - General Paediatric Unit, Necker University Hospital, Paris, France. FAU - Adnot, Pauline AU - Adnot P AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. FAU - Barbieri, Valeria AU - Barbieri V AD - General Paediatric Unit, Necker University Hospital, Paris, France. FAU - Hassler, Christine AU - Hassler C AD - CESP Centre of Epidemiology and Population Health, INSERM, Villejuif, France. FAU - Elie, Caroline AU - Elie C AD - Unit of Clinical Research, AP-HP, University Necker Hospital, Paris, France. AD - Universite Paris Cite, Inserm, Pharmacologie et Evaluations Des Therapeutiques Chez L'enfant Et La Femme Enceinte, Paris, France. FAU - Barry, Caroline AU - Barry C AD - CESP Centre of Epidemiology and Population Health, INSERM, Villejuif, France. FAU - Abadie, Veronique AU - Abadie V AUID- ORCID: 0000-0002-3525-1921 AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. AD - Paris Cite University, Paris, France. AD - CESP Centre of Epidemiology and Population Health, INSERM, Villejuif, France. LA - eng SI - ClinicalTrials.gov/NCT04133038 GR - Assistance Publique - Hopitaux de Paris/ PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260622 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Feeding and Eating Disorders of Childhood/diagnosis/psychology MH - *Feeding Behavior/psychology MH - Parents MH - Psychometrics MH - Reproducibility of Results MH - ROC Curve MH - Surveys and Questionnaires/standards PMC - PMC13539697 OTO - NOTNLM OT - assessment OT - pediatric nutrition OT - psychometric qualities COIS- The authors declare no conflicts of interest. EDAT- 2026/06/22 06:46 MHDA- 2026/09/03 17:36 PMCR- 2026/09/03 CRDT- 2026/06/22 04:23 PHST- 2026/05/20 00:00 [revised] PHST- 2025/11/23 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/03 17:36 [medline] PHST- 2026/06/22 06:46 [pubmed] PHST- 2026/06/22 04:23 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - JPN370491 [pii] AID - 10.1002/jpn3.70491 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Sep;83(3):528-535. doi: 10.1002/jpn3.70491. Epub 2026 Jun 22. PMID- 42324895 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 1097-0142 (Electronic) IS - 0008-543X (Print) IS - 0008-543X (Linking) VI - 132 IP - 13 DP - 2026 Jul 1 TI - Demographic, birth, parental characteristics, and the risk of early-onset colorectal cancer: A population-based nested case-control study in California. PG - e70458 LID - 10.1002/cncr.70458 [doi] LID - e70458 AB - BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before the age of 50 years, has been increasing. The relationship between demographic, birth, and parental characteristics and risk of EOCRC has not been elucidated. METHODS: This study included 1221 cases born and diagnosed with EOCRC at the age of 0 to 39 years in California during 1988 through 2021 and 61,050 frequency-matched controls based on birth year. Odds ratios (OR) and 95% CIs were estimated using multivariable logistic regression models. RESULTS: Based on multivariable analysis, males had 34% higher risk of EOCRC compared to females (OR = 1.34; 95% CI, 1.20-1.51), and Hispanic ethnicity was associated with 43% higher risk of EOCRC (OR for Hispanic versus non-Hispanic White = 1.34; 95% CI, 1.20-1.51). Having a foreign-born mother was associated with a lower risk of EOCRC (OR = 0.85; 95% CI, 0.73-0.97). Among females, every 500-g increase in birthweight was associated with 10% increase in EOCRC risk (OR = 1.10; 95% CI, 1.01-1.21) and having a father aged >/=35 years was associated with higher risk of EOCRC (OR = 1.56; 95% CI, 1.08-2.25). No other demographic, birth, and parental characteristic was significantly associated with risk of EOCRC. CONCLUSION: High birthweight, male sex, Hispanic ethnicity, and older paternal age are potential risk factors for EOCRC. Maternal birthplace, which is associated with diet, smoking patterns, other health-promoting characteristics, may be protective against EOCRC. These factors require future research for validation and evaluation of possible mechanisms. CI - (c) 2026 The Author(s). Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society. FAU - Siddique, Sunny AU - Siddique S AUID- ORCID: 0000-0002-5746-1161 AD - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA. FAU - Wang, Rong AU - Wang R AUID- ORCID: 0000-0002-2169-4174 AD - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA. FAU - Berardi, Domenica AU - Berardi D AD - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA. FAU - Johnson, Caroline H AU - Johnson CH AD - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA. FAU - Wiemels, Joseph L AU - Wiemels JL AD - Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. FAU - Metayer, Catherine AU - Metayer C AUID- ORCID: 0000-0003-3467-4145 AD - Division of Epidemiology, School of Public Health, University of California, Berkeley, California, USA. FAU - Ma, Xiaomei AU - Ma X AD - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA. LA - eng GR - F31 CA281335/CA/NCI NIH HHS/United States GR - 2T32CA250803-06/CA/NCI NIH HHS/United States PT - Journal Article PL - United States TA - Cancer JT - Cancer JID - 0374236 SB - IM MH - Humans MH - Female MH - California/epidemiology MH - *Colorectal Neoplasms/epidemiology MH - Male MH - Case-Control Studies MH - Risk Factors MH - Adult MH - Infant MH - Infant, Newborn MH - Adolescent MH - Child, Preschool MH - Child MH - Young Adult MH - Age of Onset MH - Parents MH - Birth Weight MH - Incidence MH - Paternal Age PMC - PMC13284631 OTO - NOTNLM OT - Hispanic ethnicity OT - birth characteristics OT - birthweight OT - colorectal cancer risk factors OT - early-life exposures OT - early-onset colorectal cancer OT - parental characteristics OT - paternal age OT - sex differences COIS- R.W. reported receiving grants from Flatiron Health outside the submitted work. X.M. reported receiving consultation fees from Bristol Myers Squibb outside the submitted work. EDAT- 2026/06/22 06:46 MHDA- 2026/06/22 13:42 PMCR- 2026/06/22 CRDT- 2026/06/22 03:12 PHST- 2026/04/17 00:00 [revised] PHST- 2025/11/21 00:00 [received] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/06/22 13:42 [medline] PHST- 2026/06/22 06:46 [pubmed] PHST- 2026/06/22 03:12 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - CNCR70458 [pii] AID - 10.1002/cncr.70458 [doi] PST - ppublish SO - Cancer. 2026 Jul 1;132(13):e70458. doi: 10.1002/cncr.70458. PMID- 42324459 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260908 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 22 TI - Determinants of out-of-home food consumption: development and validation of a multidimensional scale in a Brazilian sample. LID - 10.1186/s12889-026-28251-x [doi] LID - 2509 AB - BACKGROUND: Out-of-home food consumption has become an integral component of contemporary dietary patterns, particularly in urban contexts. Evidence suggests that eating outside the home is associated with diet quality, nutritional intake, and broader public health outcomes. However, Brazil lacks validated multidimensional instruments capable of comprehensively assessing the economic, behavioral, and experiential determinants underlying this behavior. This study aimed to develop and validate the Scale of Determinant Factors in Out-of-Home Food Consumption (SDF-OHFC) and to examine the structural relationships among its dimensions. METHODS: A cross-sectional study was conducted with 426 Brazilian adults who reported consuming food outside the home at least once per week. Data were collected through an online survey and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The measurement model was assessed for reliability, convergent and discriminant validity. Structural relationships were tested using bootstrapping procedures (5,000 resamples), and predictive performance was evaluated through R(2), Q(2), RMSE, and MAE. Measurement invariance was examined across sex, marital status, and geographic regions. RESULTS: The SDF-OHFC comprises five dimensions: economic aspects, convenience, habits and personal preferences, social and experiential aspects, and perceived food quality. The scale demonstrated satisfactory internal consistency (Cronbach's alpha = 0.705-0.762), composite reliability (> 0.70), and convergent validity (AVE > 0.50). All hypothesized structural relationships were statistically significant (p < 0.05). Economic aspects played a central antecedent role, positively influencing convenience and habits, and negatively influencing social and experiential aspects. Convenience and social and experiential dimensions were positively associated with perceived food quality. Structural invariance was confirmed across all tested demographic groups. CONCLUSIONS: The SDF-OHFC is a valid and reliable multidimensional instrument for assessing determinants of out-of-home food consumption in Brazil. By integrating economic, behavioral, and experiential factors within a single framework, the scale supports public health research and policy development aimed at improving urban food environments, promoting healthier eating practices, and addressing structural determinants of dietary behavior. CI - (c) 2026. The Author(s). FAU - Lopes, Luis Felipe Dias AU - Lopes LFD AUID- ORCID: 0000-0002-2438-0226 AD - Federal University of Santa Maria, Santa Maria, Brazil. lflopes67@yahoo.com.br. FAU - Pegoraro, Daniela AU - Pegoraro D AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - de Oliveira, Rayssa Cleide AU - de Oliveira RC AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - Lopes, Eduarda Grando AU - Lopes EG AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - Saragozo, Rosangela Arruda AU - Saragozo RA AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - da Silva, Deoclecio Junior Cardoso AU - da Silva DJC AD - Pontifical Catholic University of Parana, Curitiba, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260622 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Brazil MH - Female MH - Male MH - Cross-Sectional Studies MH - Adult MH - Reproducibility of Results MH - Middle Aged MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires/standards MH - Young Adult MH - Adolescent MH - Socioeconomic Factors PMC - PMC13536861 OTO - NOTNLM OT - Brazil OT - Eating behavior OT - Food environment OT - Out-of-home food consumption OT - Psychometric validation OT - Public health COIS- Declarations. Ethical approval and consent to participate: This study was conducted in accordance with the ethical standards for research involving human participants. The research protocol was reviewed and approved by the Research Ethics Committee of the Federal University of Santa Maria, Brazil (Approval No. 4,469,026; CAAE: 40303720.5.0000.5346). All participants provided informed consent prior to participation. Data collection was anonymous, voluntary, and conducted in compliance with national and international ethical guidelines. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/22 00:43 MHDA- 2026/09/02 05:36 PMCR- 2026/06/22 CRDT- 2026/06/21 23:29 PHST- 2026/02/14 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/22 00:43 [pubmed] PHST- 2026/06/21 23:29 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12889-026-28251-x [pii] AID - 28251 [pii] AID - 10.1186/s12889-026-28251-x [doi] PST - epublish SO - BMC Public Health. 2026 Jun 22;26(1):2509. doi: 10.1186/s12889-026-28251-x. PMID- 42324338 OWN - NLM STAT- Publisher LR - 20260721 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 21 TI - Serum inflammatory and metabolic signatures accelerate precocious puberty in obese children. LID - 10.1038/s41390-026-05214-x [doi] AB - BACKGROUND: This study aimed to characterize the interplay of metabolic, hormonal, and inflammatory factors in precocious puberty and obesity. METHODS: This cross-sectional study enrolled 417 children were included Control (n = 97), Obesity (n = 102), Central Precocious Puberty (CPP, n = 103), and obesity with precocious puberty group (OPP, n = 115) groups. Basic anthropometric, hormonal, metabolic, and inflammatory indicators were analyzed. Group comparisons were performed using ANOVA/Kruskal-Wallis tests. Receiver operating characteristic (ROC) curve was applied to assess biomarkers for predicting precocious puberty in obese children, and Spearman correlation evaluated biomarker relationships. RESULTS: Bone age advancement and elevated levels of LH, FSH, and IGF-1 were observed in both the CPP and OPP group compared to the Controls. ROC curve indicated that IGF-1 had high predictive value (AUC = 0.810) for precocious puberty in obese children. The Obesity and OPP groups exhibited significantly elevated triglycerides, liver enzymes (GGT, ALT), and inflammatory indices (NLR, WBC) relative to the CPP group. OPP correlated positively with LH, FSH, TC, NLR, and IGF-1. CONCLUSION: Obesity-associated precocious puberty involves concurrent elevations in hormonal, metabolic, and inflammatory biomarkers. Clinical management of pubertal disorders in children with obesity should incorporate integrated assessment of inflammatory and metabolic dysregulation alongside endocrine markers. IMPACT: It provides comparative evidence that the obesity-associated precocious puberty exhibits a more severe metabolic and inflammatory profile than the Central Precocious Puberty without obesity, suggesting obesity exacerbates these dysregulations alongside puberty timing. The findings strongly argue that clinical management of precocious puberty in obese children requires an integrated approach, assessing not just hormonal markers but also metabolic health and inflammation for comprehensive evaluation. It underscores the complex interplay and potential shared mechanisms between metabolic dysfunction, inflammation, and the hormonal activation of puberty, emphasizing the need for future research to investigate these interconnected pathways in pediatric endocrine disorders. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Wang, Li AU - Wang L AD - Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China. FAU - Yan, Heqiu AU - Yan H AD - Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China. FAU - Liu, Jun AU - Liu J AD - Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Endocrine Genetics and Metabolism, School of Medicine, Chengdu Women's and Children's Center Hospital, University of Electronic Science and Technology of China, Chengdu, China. FAU - Cheng, Xinran AU - Cheng X AD - Department of Endocrine Genetics and Metabolism, School of Medicine, Chengdu Women's and Children's Center Hospital, University of Electronic Science and Technology of China, Chengdu, China. FAU - Yao, Haibo AU - Yao H AD - Department of Medical Records, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Tang, Fang AU - Tang F AD - Department of Endocrine Genetics and Metabolism, School of Medicine, Chengdu Women's and Children's Center Hospital, University of Electronic Science and Technology of China, Chengdu, China. FAU - Luo, Mengjun AU - Luo M AD - Department of Clinical Laboratory, Chengdu Women's and Children's Center Hospital. School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. 462816877@qq.com. LA - eng PT - Journal Article DEP - 20260621 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was reviewed and approved by the Ethics Committee of Chengdu Women and Children's Central Hospital (Grant No.2021(140)) and conducted in accordance with the Declaration of Helsinki. The parents and/or legal guardian provided their written informed consent to participate in this study. EDAT- 2026/06/22 00:43 MHDA- 2026/06/22 00:43 CRDT- 2026/06/21 23:21 PHST- 2025/07/22 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2025/11/04 00:00 [revised] PHST- 2026/06/22 00:43 [pubmed] PHST- 2026/06/22 00:43 [medline] PHST- 2026/06/21 23:21 [entrez] AID - 10.1038/s41390-026-05214-x [pii] AID - 10.1038/s41390-026-05214-x [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 21. doi: 10.1038/s41390-026-05214-x. PMID- 42324210 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260621 IS - 1476-4954 (Electronic) IS - 1476-4954 (Linking) VI - 39 IP - 1 DP - 2026 Dec TI - Association between maternal cardiovascular health assessed by modified Life's Essential 8 and risks of adverse pregnancy outcomes. PG - 2682080 LID - 10.1080/14767058.2026.2682080 [doi] AB - BACKGROUND: The American Heart Association (AHA) has updated the definition of cardiovascular health (CVH) from "Life's Simple 7" (LS7) to "Life's Essential 8" (LE8). The association between gestational LE8 CVH status and adverse pregnancy outcomes is unclear. METHODS: We recruited pregnant women from the China birth cohort study during 6-13(+6) gestation weeks and followed them up until delivery to identify pregnancy outcomes. According to the modified AHA definitions, baseline gestational modified LE8 (mLE8) and LS7 CVH scores were calculated based on body mass index, nicotine exposure, physical activity, diet, blood pressure, blood glucose, and lipid levels. Multivariable adjusted logistic regression and receiver operating characteristic (ROC) curves were used to investigate the association between gestational CVH and adverse pregnancy outcomes. RESULTS: Among the 5168 pregnant women finally included, the overall gestational mLE8 CVH score was 81.4 +/- 9.6 points. After multivariate adjustment, each 10-points increase in the total overall gestational mLE8 CVH score was significantly associated with a decreased risk of pregnancy loss [odds ratio (OR) = 0.85, 95% CI: 0.76-0.95), hypertensive disorders of pregnancy (OR = 0.50, 95% CI: 0.44-0.58), gestational diabetes mellitus (GDM) (OR = 0.62, 95% CI: 0.57-0.67), preterm birth (OR = 0.76, 95% CI: 0.67-0.86), large-for-gestational age (LGA) (OR = 0.81, 95% CI: 0.73-0.90), and cesarean delivery (OR = 0.77, 95% CI: 0.72-0.82)]. The areas under the ROC curves (AUC) of mLE8 were higher than those of LS7 for pregnancy loss (0.553 vs. 0.537, p = 0.031), GDM (0.626 vs. 0.615, p = 0.023), LGA (0.575 vs. 0.557, p = 0.016), and cesarean delivery (0.574 vs. 0.564, p = 0.005). CONCLUSIONS: Higher gestational mLE8 CVH scores in the first trimester are significantly associated with a lower risk of adverse pregnancy outcomes. Although the capacity to predict adverse pregnancy outcomes was modest, mLE8 slightly outperformed LS7 in predicting PE, GDM, LGA, and cesarean delivery. FAU - Gao, Shen AU - Gao S AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Su, Shaofei AU - Su S AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Zhang, Enjie AU - Zhang E AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Zhang, Yue AU - Zhang Y AD - Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Liu, Jianhui AU - Liu J AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Xie, Shuanghua AU - Xie S AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Cui, Yuchen AU - Cui Y AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Li, Shuangying AU - Li S AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Yue, Wentao AU - Yue W AD - Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Liu, Ruixia AU - Liu R AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Yin, Chenghong AU - Yin C AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. LA - eng PT - Journal Article DEP - 20260621 PL - England TA - J Matern Fetal Neonatal Med JT - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JID - 101136916 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - *Pregnancy Outcome/epidemiology MH - China/epidemiology MH - Infant, Large for Gestational Age MH - Risk Factors MH - Vascular Health MH - *Maternal Health MH - Infant, Newborn MH - Cohort Studies OTO - NOTNLM OT - Cardiovascular health OT - Life's Essential 8 OT - Life's Simple 7 OT - cohort study OT - pregnancy outcomes EDAT- 2026/06/22 00:43 MHDA- 2026/06/22 13:42 CRDT- 2026/06/21 22:23 PHST- 2026/06/22 13:42 [medline] PHST- 2026/06/22 00:43 [pubmed] PHST- 2026/06/21 22:23 [entrez] AID - 10.1080/14767058.2026.2682080 [doi] PST - ppublish SO - J Matern Fetal Neonatal Med. 2026 Dec;39(1):2682080. doi: 10.1080/14767058.2026.2682080. Epub 2026 Jun 21. PMID- 42323926 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260820 IS - 1873-2364 (Electronic) IS - 0960-8966 (Linking) VI - 65 DP - 2026 Aug TI - Systematic review of outcome measures in facioscapulohumeral dystrophy (FSHD): validated, usable, and feasible tools for assessing function, performance, and strength. PG - 106470 LID - S0960-8966(26)00138-0 [pii] LID - 10.1016/j.nmd.2026.106470 [doi] AB - Facioscapulohumeral dystrophy (FSHD) is a dominantly inherited muscle-wasting condition with no approved therapies. Symptom variability complicates clinical evaluation, and despite the necessity of function-based measures to bridge research and real-world outcomes, no international consensus on a core assessment set exists. This systematic review evaluated the psychometric properties, feasibility, and comprehensiveness of published function-based outcome measures in FSHD, to help guide late-phase trials, and clinical practice. A systematic search of six databases with a data cut in January 2026 identified 366 studies and 51 outcome measures, which were appraised using the COSMIN framework. The results showed that while the FSHD Clinical Score, Clinical Severity Score, and 6-minute walk test are the most frequently utilised, no measure achieved higher than a 'Moderate' rating. Most supporting evidence remains 'Low,' with critical gaps identified for wheelchair users and paediatric populations. Digital outcome measures showed promise for improving responsiveness and enabling remote assessment.Our systematic review highlights an urgent need for a consensus-based approach to harmonize data together with international efforts such as MOVE/RESOLVE-FSHD providing direct support to upcoming initiatives like ENMC-FSHD-outcomes- workshop and the PaLaDIn project. Such efforts will allow researchers to enhance real-world evidence synthesis and improve success of future clinical trials. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Hewamadduma, Channa AU - Hewamadduma C AD - Academic Unit of Neuromuscular Disorders, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, , UK; Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. Electronic address: chewamadduma1@sheffield.ac.uk. FAU - Street, Jon AU - Street J AD - Academic Unit of Neuromuscular Disorders, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, , UK; Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. FAU - Massey, Charlotte AU - Massey C AD - Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. FAU - McDermott, Christopher J AU - McDermott CJ AD - Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. FAU - Weatherley, Emma AU - Weatherley E AD - FSHD Global Research Foundation, Sydney, Australia. FAU - Voermans, Nicol C AU - Voermans NC AD - Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands. FAU - Statland, Jeff AU - Statland J AD - Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA. FAU - Schoser, Benedikt AU - Schoser B AD - Friedrich-Baur-Institute, Department of Neurology LMU Clinic Munich, Munich, Germany. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260611 PL - England TA - Neuromuscul Disord JT - Neuromuscular disorders : NMD JID - 9111470 SB - IM MH - *Muscular Dystrophy, Facioscapulohumeral/physiopathology/diagnosis/therapy MH - Humans MH - *Outcome Assessment, Health Care MH - *Muscle Strength MH - Psychometrics MH - Severity of Illness Index OTO - NOTNLM OT - COSMIN OT - FSHD OT - Facioscapulohumeral muscular dystrophy OT - Outcome measures OT - Systematic review COIS- Declaration of competing interest CH: NCI/PI in clinical trials sponsored by UCB, Roche, Biogen, Avidity, Dyne, Argenx, JnJ, Remgen, Alexion, and Novartis and have received speaker honoraria and consultancy from UCB, Roche, Biogen, Avidity, Argenx, Alexion and Novartis. JS: received travel grant from FSHD Society CM: discloses the following conflicts of interest: Consultancy: Dyne therapeutics, Avidity, Lupin Neurosciences, Arthex Bio tech, PepGen. CJM: reports no conflicts of interest relevant to this work JS: received grant funding from NIH, CDC, MDA, FSHD Society, FSHD Canada, Friends of FSHD Research, ALSA; consultant or on scientific advisory board or steering committee for Avidity, Dyne, Roche, Novartis, Scholar Rock, Alnylam, Vertex, Souffle, Merck, and Sanofi NV: Consultancy: Avidity, Spolia, Astellas and Souffle (all financial compensation paid to her institution). BS: discloses the following conflicts of interest: Research support: DFG CAESAR, EU Horizon 2022 ComPASS; PaLaDIn; Entry-DM. Lecture support: Amicus, Alexion, Argenx, Astellas, Kedrion, Sanofi. Consultancy: Amicus, Astellas, Avidity, Denali, Dyne, Johnson&Johnson, Sanofi, Souffle, UCB. EDAT- 2026/06/21 22:33 MHDA- 2026/08/04 00:35 CRDT- 2026/06/21 17:59 PHST- 2026/04/18 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/06/21 22:33 [pubmed] PHST- 2026/06/21 17:59 [entrez] AID - S0960-8966(26)00138-0 [pii] AID - 10.1016/j.nmd.2026.106470 [doi] PST - ppublish SO - Neuromuscul Disord. 2026 Aug;65:106470. doi: 10.1016/j.nmd.2026.106470. Epub 2026 Jun 11. PMID- 42323690 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260913 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jun 20 TI - Karyotype-specific cardiovascular and metabolic profiles in Turner syndrome: a retrospective echocardiographic study. LID - 10.1186/s13023-026-04457-5 [doi] LID - 315 AB - BACKGROUND: Turner syndrome (TS) is associated with cardiovascular abnormalities and metabolic risk, but karyotype-specific phenotypes remain incompletely defined, particularly in pediatric and adolescent cohorts assessed by transthoracic echocardiography (TTE). METHODS: We conducted a retrospective cross-sectional study of 289 patients with TS evaluated between October 2016 and October 2023. Patients were grouped as 45,X monosomy (n = 149) or mosaic/structural karyotypes (n = 140). Baseline or preoperative TTE data were used. The primary endpoint was a clinically relevant structural cardiovascular disease (CVD) composite based on explicit baseline/preoperative diagnoses of major lesions; patent foramen ovale, isolated persistent left superior vena cava, and minor valve regurgitation were treated as descriptive findings. Aortic dilatation based on ASI > 20 mm/m(2) was analyzed separately as an aortic-size phenotype. RESULTS: The structural CVD composite was more frequent in the 45,X group than in the mosaic/structural group (49/149 [32.9%] vs. 26/140 [18.6%], p = 0.006). In multivariable logistic regression, 45,X remained associated with the structural CVD composite after adjustment for age, BMI, systolic blood pressure, LDL-C, and HOMA-IR (OR 1.88, 95% CI 1.05-3.35; p = 0.033). Aortic dilatation by ASI > 20 mm/m(2) did not differ significantly between groups (28.9% vs. 32.9%, p = 0.462). Elevated total cholesterol was more frequent in the 45,X group, and LDL-C was independently associated with the structural CVD composite. LVDD was modestly lower in the 45,X group (33.6 +/- 6.6 vs. 35.4 +/- 6.4 mm; p = 0.017). CONCLUSIONS: In this single-center TS cohort, 45,X monosomy was associated with a higher burden of clinically relevant structural cardiovascular abnormalities and an adverse lipid profile, whereas ASI-defined aortic dilatation alone did not differ significantly by karyotype. These findings support karyotype-aware cardiovascular surveillance, while underscoring the need for cautious interpretation of small TTE differences and validation in multicenter longitudinal studies. CI - (c) 2026. The Author(s). FAU - Huang, Yinchun AU - Huang Y AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Luo, Song AU - Luo S AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Qi, Yiying AU - Qi Y AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Qin, Shuang AU - Qin S AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Yue, Chaomin AU - Yue C AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Lu, Qinsheng AU - Lu Q AD - Division of Uterine Vascular Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Lash, Gendie E AU - Lash GE AD - Division of Uterine Vascular Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Li, Li AU - Li L AUID- ORCID: 0000-0001-8832-0575 AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. lilyli1973@126.com. LA - eng GR - 2023A1515010216/Science Fund for Distinguished Young Scholars of Guangdong Province/ GR - 2022B1515120074/Basic and Applied Basic Research Foundation of Guangdong Province/ GR - 2024A03J1175/Guangzhou Science, Technology and Innovation Commission/ PT - Journal Article DEP - 20260620 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - *Turner Syndrome/genetics/metabolism/diagnostic imaging MH - Female MH - Retrospective Studies MH - Echocardiography/methods MH - Cross-Sectional Studies MH - Adolescent MH - Karyotype MH - Child MH - Cardiovascular Diseases/genetics/metabolism MH - Karyotyping PMC - PMC13563905 OTO - NOTNLM OT - 45,X OT - Aortic size index OT - Cardiovascular disease OT - Dyslipidemia OT - Echocardiography OT - Karyotype OT - Mosaicism OT - Turner syndrome COIS- Declarations. Ethics approval and consent to participate: The study protocol was reviewed and approved by the Scientific Research Ethics Committee of Guangzhou Women and Children's Medical Center, Guangzhou Medical University (approval No. Sui Fu Er Ke Lun Pi Zi [2025] No. 261A01; approval date: 14 August 2025). Informed consent was obtained from participants and/or their legal guardians in accordance with the approved protocol. All data were analyzed in aggregate form without identifying individual participants. Consent for publication: Informed consent for the publication of data was obtained from all participants or their legal caregivers. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/06/21 22:34 MHDA- 2026/09/11 05:36 PMCR- 2026/06/20 CRDT- 2026/06/20 23:27 PHST- 2025/12/24 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/11 05:36 [medline] PHST- 2026/06/21 22:34 [pubmed] PHST- 2026/06/20 23:27 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - 10.1186/s13023-026-04457-5 [pii] AID - 4457 [pii] AID - 10.1186/s13023-026-04457-5 [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jun 20;21(1):315. doi: 10.1186/s13023-026-04457-5. PMID- 42323577 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260917 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 20 TI - Evaluability and feasibility of an intervention combining gaming and social activities to improve mental wellbeing and health behaviour in adolescents facing social challenges. LID - 10.1186/s12887-026-07172-z [doi] LID - 821 AB - BACKGROUND: Adolescents in Denmark increasingly report poor mental wellbeing and health behaviour. Additionally, they spend less time being physically active and being with friends and more time on gaming and social media. The eHOOD intervention was developed to address physical and mental wellbeing of adolescents in vulnerable positions using their motivation for gaming to engage them in a community entailing physical and social activity, and education with peers. This study aimed to assess the evaluability of the eHOOD intervention, to develop an evaluation design, and to test the feasibility and acceptability of the evaluation design and the intervention. METHODS: Evaluability assessment was performed by a working group in a series of workshop-style meetings involving a literature review, creation of a theory of change, and preparation of an evaluation plan including outcome measures, instruments, and data collection procedures. Subsequently the evaluation design and the intervention were tested in a single arm feasibility study. Participants were 13 adolescents aged 13-16 years. The participants met with a coach and a local pedagogue in an after-school club four hours a week for 25 weeks practicing gaming, engaging in physical and social activities, and learning about healthy lifestyle habits through education and communal cooking and dining. Feasibility and acceptability of outcome measures, instruments, and data collection procedures were assessed, and initial changes in outcome measures were measured. Recruitment and retainment of participants were monitored, and participants' motivation for and benefits of participating were explored. Data were collected with qualitative and quantitative methods. RESULTS: An evaluation plan was developed and found to be suitable for use in the subsequent feasibility study. The evaluation design was overall feasible and acceptable, although several important adjustments to measurements and data collection procedures were identified. Initial changes in wellbeing were observed and the World Health Organization-Five Well-Being Index (WHO-5) was deemed relevant as a primary outcome in future evaluation. The intervention was found feasible and acceptable among participants in the present format. CONCLUSIONS: This combined evaluability assessment and feasibility study suggests that the eHOOD intervention is ready for larger-scale evaluation, although refinements to outcome measures and data collection procedures are warranted before effectiveness can be evaluated. TRIAL REGISTRATION: ClinicalTrials.gov, March 23, 2026. Identifier NCT07489365. Retrospectively registered. CI - (c) 2026. The Author(s). FAU - Grew, Julie Christina AU - Grew JC AUID- ORCID: 0000-0001-5770-9174 AD - Center for Clinical Research and Prevention, Copenhagen University Hospital - Frederiksberg, Nordre Fasanvej 57, Hovedvejen 5, Frederiksberg, 2000, Denmark. julie.grew@regionh.dk. FAU - Gotzsche, Nina AU - Gotzsche N AD - Center for Clinical Research and Prevention, Copenhagen University Hospital - Frederiksberg, Nordre Fasanvej 57, Hovedvejen 5, Frederiksberg, 2000, Denmark. FAU - Broberg, Lotte AU - Broberg L AD - Center for Clinical Research and Prevention, Copenhagen University Hospital - Frederiksberg, Nordre Fasanvej 57, Hovedvejen 5, Frederiksberg, 2000, Denmark. AD - Department of Gynecology and Obstetrics, Slagelse Hospital, Faelledvej 14, Slagelse, 4200, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, 2200, Denmark. FAU - Schiotz, Michaela Louise AU - Schiotz ML AD - Center for Clinical Research and Prevention, Copenhagen University Hospital - Frederiksberg, Nordre Fasanvej 57, Hovedvejen 5, Frederiksberg, 2000, Denmark. AD - Department of Public Health, University of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark. LA - eng SI - ClinicalTrials.gov/NCT07489365 PT - Clinical Trial PT - Journal Article DEP - 20260620 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - *Adolescent Behavior/psychology MH - Denmark MH - Exercise/psychology MH - Feasibility Studies MH - *Health Behavior MH - *Health Promotion/methods MH - *Mental Health MH - Motivation MH - Program Evaluation MH - Psychological Well-Being MH - *Video Games/psychology PMC - PMC13536880 OTO - NOTNLM OT - Acceptability OT - Adolescents OT - Evaluability assessment OT - Evaluation design OT - Feasibility OT - Gaming OT - Loneliness OT - Mental wellbeing OT - Physical activity OT - Social activity COIS- Declarations. Ethics approval and consent to participate: The Danish Data Protection Agency assessed the study and categorized it as a quality improvement project, of which registration is redundant. The Regional Health Research Ethics Committees in the Capital Region of Denmark waived the need for ethical approval of the project (ref. no.: F-25073292). Informed consent to participate was obtained from the parents of the participants who were under the age of 16. One participant was 16 years old and, therefore, gave written informed consent herself. The study was performed in accordance with the Declaration of Helsinki. All data were handled in accordance with the GDPR. The study was retrospectively registered at ClinicalTrials.gov (NCT07489365) on March 23, 2026. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/21 22:33 MHDA- 2026/09/02 05:36 PMCR- 2026/06/20 CRDT- 2026/06/20 23:24 PHST- 2026/03/30 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/21 22:33 [pubmed] PHST- 2026/06/20 23:24 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - 10.1186/s12887-026-07172-z [pii] AID - 7172 [pii] AID - 10.1186/s12887-026-07172-z [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 20;26(1):821. doi: 10.1186/s12887-026-07172-z. PMID- 42322788 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260808 IS - 1872-8421 (Electronic) IS - 0165-5728 (Linking) VI - 419 DP - 2026 Oct TI - Brain volumetric changes in pediatric seronegative autoimmune encephalitis: A case-control study. PG - 579009 LID - S0165-5728(26)00158-X [pii] LID - 10.1016/j.jneuroim.2026.579009 [doi] AB - Seronegative autoimmune encephalitis (SNAE) is an increasingly recognized entity in pediatric neurology, yet quantitative neuroimaging data remain scarce. This study aimed to evaluate regional brain volumetric differences between children diagnosed with SNAE and age- and sex-matched healthy controls using automated MRI volumetry. Fifteen children with SNAE (median age 12 years; 9 males, 6 females) and 45 age- and sex-matched healthy controls were enrolled. Three-dimensional T1-weighted MRI data were processed using the volBrain automated brain volumetry pipeline. Whole brain, grey matter, white matter, and subcortical structure volumes (thalamus, putamen, caudate, pallidum, hippocampus, amygdala, cerebellum, and brainstem) were compared between groups. Receiver operating characteristic (ROC) curve analysis was performed to determine the discriminative value of significantly different volumetric parameters. Patients with SNAE demonstrated significantly lower absolute grey matter, thalamus, putamen, and pallidum volumes compared with healthy controls after Bonferroni correction. Following ICV-normalization, only putamen and pallidum volumes remained significantly reduced in the patient group. ROC analyses demonstrated significant discriminative performance for several volumetric parameters, with putamen showing the numerically highest AUROC among absolute volumetric measures (AUROC = 0.875) and pallidum showing the highest AUROC among ICV-normalized measures (AUROC = 0.769). Pairwise DeLong comparisons revealed that the ROC performances of these parameters were statistically indistinguishable within this sample. Automated brain volumetry may provide quantitative information complementary to conventional MRI evaluation in pediatric SNAE. Larger prospective studies are needed to validate the clinical significance of these findings. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Deniz, Adnan AU - Deniz A AD - Department of Pediatric Neurology, Kocaeli City Hospital, Kocaeli, Turkiye. Electronic address: adnandeniz85@hotmail.com. FAU - Ozer, Torehan AU - Ozer T AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. FAU - Balci, Sibel AU - Balci S AD - Department of Biostatistics, Faculty of Medicine, Marmara University, Istanbul, Turkiye. FAU - Gunes, Ayfer Sakarya AU - Gunes AS AD - Department of Pediatric Neurology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. FAU - Orgun, Leman Tekin AU - Orgun LT AD - Department of Pediatric Neurology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. FAU - Anik, Yonca AU - Anik Y AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. FAU - Kara, Bulent AU - Kara B AD - Department of Pediatric Neurology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. LA - eng PT - Journal Article DEP - 20260619 PL - Netherlands TA - J Neuroimmunol JT - Journal of neuroimmunology JID - 8109498 RN - Hashimoto's encephalitis SB - IM MH - Humans MH - Female MH - Child MH - Male MH - *Brain/diagnostic imaging/pathology MH - Case-Control Studies MH - Magnetic Resonance Imaging/methods MH - Adolescent MH - *Encephalitis/diagnostic imaging/pathology/blood MH - Organ Size MH - *Hashimoto Disease/diagnostic imaging/pathology OTO - NOTNLM OT - Brain volumetry OT - Cerebellum OT - MRI OT - Pediatric OT - Putamen OT - Seronegative autoimmune encephalitis OT - Subcortical structures COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/06/21 22:38 MHDA- 2026/08/09 00:43 CRDT- 2026/06/20 18:04 PHST- 2026/03/30 00:00 [received] PHST- 2026/06/13 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/09 00:43 [medline] PHST- 2026/06/21 22:38 [pubmed] PHST- 2026/06/20 18:04 [entrez] AID - S0165-5728(26)00158-X [pii] AID - 10.1016/j.jneuroim.2026.579009 [doi] PST - ppublish SO - J Neuroimmunol. 2026 Oct;419:579009. doi: 10.1016/j.jneuroim.2026.579009. Epub 2026 Jun 19. PMID- 42322732 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260805 IS - 1872-7131 (Electronic) IS - 0387-7604 (Linking) VI - 48 IP - 4 DP - 2026 Aug TI - Urine protein/osmolality and creatinine/osmolality ratios for assessing proteinuria and motor function in children with spinal muscular atrophy. PG - 104563 LID - S0387-7604(26)00064-1 [pii] LID - 10.1016/j.braindev.2026.104563 [doi] AB - BACKGROUND: Spinal muscular atrophy (SMA) is characterized by the degeneration of anterior horn motor neurons. While nusinersen has altered the natural course of SMA, it may accumulate in the kidneys, leading to proteinuria. Therefore, routine pre-dose urine monitoring for proteinuria is recommended. To address this issue, we aimed to evaluate the urinary protein-to-osmolality ratio (U(Pr/Osm)). We also aimed to evaluate the relation of urinary creatinine-to-osmolality ratio (U(Cr/Osm)) to motor function scores. METHODS: A retrospective study was performed on 42 SMA patients. U(Pr/Cr), U(Pr/Osm), and U(Cr/Osm) ratios were calculated. U(Pr/Cr) and U(Pr/Osm) were compared for the presence of proteinuria, while correlation analysis between U(Cr/Osm) and motor scores was performed using CHOP INTEND in patients aged 0-2 years and HFMSE separately in the 2-6 years, 6-12 years, and > 12 years age groups. Furthermore, laboratory parameters were compared between ambulatory and non-ambulatory patients. RESULTS: The cohort included 17 patients with SMA type 1, 18 with type 2, and 7 with type 3. Proteinuria was detected in 35 (83%) patients using U(Pr/Cr), whereas only 4 (10%) or 9 (21%) patients had proteinuria with respect to different U(Pr/Osm) cut-offs defined in the literature. U(Cr/Osm) was significantly higher in ambulatory patients. On the other hand, U(Cr/Osm) was correlated with HFMSE scores in the older age groups (6-12 years and > 12 years) (r = 0.553, p = 0.033; r = 0.717, p = 0.02). CONCLUSIONS: The U(Pr/Osm) test may be a reliable alternative for assessing proteinuria in patients with SMA. U(Cr/Osm) may also be associated with motor function in patients with later-stage SMA. CI - Copyright (c) 2024. Published by Elsevier B.V. FAU - Senol, Huseyin Bahadir AU - Senol HB AD - Department of Pediatric Neurology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. Electronic address: huseyinbahadirsenol@gmail.com. FAU - Yildiz, Gizem AU - Yildiz G AD - Department of Pediatric Nephrology, Denizli State Hospital, Denizli, Turkey. FAU - Caglar, Ezgi AU - Caglar E AD - Department of Pediatric Neurology, Mersin University Faculty of Medicine, Mersin, Turkey. FAU - Komur, Mustafa AU - Komur M AD - Department of Pediatric Neurology, Mersin University Faculty of Medicine, Mersin, Turkey. FAU - Dogan, Gizem AU - Dogan G AD - Department of Pediatric Neurology, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey. FAU - Uzan, Gamze Sarikaya AU - Uzan GS AD - Department of Pediatric Neurology, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey. FAU - Polat, Ayse Ipek AU - Polat AI AD - Department of Pediatric Neurology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. FAU - Aydin, Adem AU - Aydin A AD - Department of Pediatric Neurology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. FAU - Hiz, Ayse Semra AU - Hiz AS AD - Department of Pediatric Neurology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. FAU - Soylu, Alper AU - Soylu A AD - Department of Pediatric Nephrology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. FAU - Yis, Uluc AU - Yis U AD - Department of Pediatric Neurology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. LA - eng PT - Journal Article DEP - 20260620 PL - Netherlands TA - Brain Dev JT - Brain & development JID - 7909235 RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - *Proteinuria/urine/diagnosis/physiopathology MH - Child MH - Male MH - Retrospective Studies MH - Child, Preschool MH - Female MH - *Creatinine/urine MH - Osmolar Concentration MH - Infant MH - *Muscular Atrophy, Spinal/urine/physiopathology/complications MH - Adolescent MH - *Motor Activity/physiology OTO - NOTNLM OT - Antisense oligonucleotide OT - Motor assessment OT - Nusinersen OT - Proteinuria OT - Spinal muscular atrophy OT - Urine creatinine/osmolality OT - Urine osmolality OT - Urine protein/osmolality COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/21 22:31 MHDA- 2026/08/06 11:36 CRDT- 2026/06/20 18:02 PHST- 2026/02/09 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/08/06 11:36 [medline] PHST- 2026/06/21 22:31 [pubmed] PHST- 2026/06/20 18:02 [entrez] AID - S0387-7604(26)00064-1 [pii] AID - 10.1016/j.braindev.2026.104563 [doi] PST - ppublish SO - Brain Dev. 2026 Aug;48(4):104563. doi: 10.1016/j.braindev.2026.104563. Epub 2026 Jun 20. PMID- 42322639 OWN - NLM STAT- MEDLINE DCOM- 20260620 LR - 20260620 IS - 1464-3502 (Electronic) IS - 0735-0414 (Linking) VI - 61 IP - 4 DP - 2026 May 13 TI - Interpretable machine learning for rare events: an inverse probability weighted application to understanding glucagon-like peptide-1 receptor agonists use and incident alcohol-related disorder. LID - agag045 [pii] LID - 10.1093/alcalc/agag045 [doi] AB - OBJECTIVE: Large administrative datasets enable investigation of rare outcomes, but accurate individual-level prediction remains challenging. Emerging evidence suggests that glucagon-like peptide-1 receptor agonists (GLP-1 RAs), used to treat diabetes and obesity, may reduce alcohol craving and intake. We examined predictors of incident alcohol-related disorder (ARD) using inverse probability-weighted (IPW) machine learning models, focusing on GLP-1 RA use. METHODS: We conducted a retrospective cohort study using the MarketScan Multi-State Medicaid Database (N = 96 460). Type 2 diabetic adults aged 18-64 years with GLP-1 RA prescription coverage (2022-2023) and no ARD in 2022 were included. Baseline variables included demographics, social risk factors (Z-codes), comorbidities, insurance characteristics, and GLP-1 RA use. Propensity scores were used to derive stabilized IPW weights to adjust for confounding in GLP-1 RA exposure. An Extreme Gradient Boosting model with IPW was trained using a 70/30 train-test split with five-fold cross-validation and probability calibration. Performance was evaluated using Area Under the Receiver Operating Characteristics Curve (AUROC), recall, and precision. Model interpretability was assessed using SHapley Additive exPlanations (SHAP). RESULTS: GLP-1 RAs were used by 21.7% of individuals; 2.1% (N = 2004) developed incident ARD. The model demonstrated modest discrimination (AUROC = 0.67). Recall and precision were 0.28 and 0.05, respectively. SHAP analysis ranked GLP-1 RA use as the sixth most influential predictor and showed an association with lower predicted ARD risk. CONCLUSION: Predicting rare outcomes remains difficult, particularly for identifying positive cases. Interpretable machine learning identified GLP-1 RA use as an important feature associated with lower predicted ARD risk, warranting further investigation. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Medical Council on Alcohol and Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Gautam, Rinoj AU - Gautam R AD - College of Pharmacy, UNT Health, Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. FAU - Wang, Hao AU - Wang H AUID- ORCID: 0000-0002-5105-0951 AD - Department of Emergency Medicine, JPS Health Network, 1500 S. Main St., Fort Worth, TX 76104, United States. FAU - Zhou, Bo AU - Zhou B AD - College of Pharmacy, UNT Health, Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. FAU - Neba, Rolake AU - Neba R AD - College of Pharmacy, UNT Health, Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. FAU - Sambamoorthi, Usha AU - Sambamoorthi U AD - Health Outcomes Research and AI Innovation, Department of Pharmacy Practice, School of Pharmacy, Temple University, 1801 N. Broad St., Philadelphia, PA 19140, United States. LA - eng GR - 5S21MD012472-05/National Institute on Minority Health and Health Disparities through the Texas Center for Health Disparities (NIMHD)/ GR - 1OT2OD032581-01/National Institutes of Health/Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity/ PT - Journal Article PL - England TA - Alcohol Alcohol JT - Alcohol and alcoholism (Oxford, Oxfordshire) JID - 8310684 RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) SB - IM MH - Humans MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - *Machine Learning MH - Retrospective Studies MH - Female MH - Adult MH - Middle Aged MH - Male MH - Predictive Learning Models MH - *Diabetes Mellitus, Type 2/drug therapy MH - *Alcohol-Related Disorders/epidemiology MH - Young Adult MH - United States/epidemiology MH - Adolescent MH - Prediction Algorithms MH - Probability MH - Boosting Machine Learning Algorithms OTO - NOTNLM OT - GLP-1 receptor agonists OT - Medicaid OT - alcohol-related disorder OT - inverse probability weighting OT - machine learning EDAT- 2026/06/21 22:34 MHDA- 2026/06/21 22:35 CRDT- 2026/06/20 14:33 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/16 00:00 [accepted] PHST- 2026/06/21 22:35 [medline] PHST- 2026/06/21 22:34 [pubmed] PHST- 2026/06/20 14:33 [entrez] AID - 8712561 [pii] AID - 10.1093/alcalc/agag045 [doi] PST - ppublish SO - Alcohol Alcohol. 2026 May 13;61(4):agag045. doi: 10.1093/alcalc/agag045. PMID- 42322485 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260620 LR - 20260813 IS - 2199-1170 (Print) IS - 2198-9761 (Electronic) IS - 2198-9761 (Linking) VI - 12 IP - 1 DP - 2026 Jun 20 TI - Temporal Trends in Health-Related Components of Physical Fitness of European Children and Adolescents from 1965 to 2025: A Systematic Review of Data on 417,362 Participants from 20 Countries. LID - 10.1186/s40798-026-01032-x [doi] LID - 77 AB - BACKGROUND: Physical fitness is an important indicator of health during childhood and adolescence. Several components of physical fitness showed declining trends, with periods of acceleration or stabilisation depending on the component. Although Europe is the most studied continent, existing reviews have largely relied on single-test approaches or descriptive summaries, without simultaneously examining all health-related components, accounting for between-study variability analyses, or extending monitoring beyond 2014 to include the COVID-19 pandemic. This systematic review aims to analyse temporal trends of health-related components of physical fitness in European children and adolescents aged 6-16 years, examining differences by sex and age groups. METHODS: A systematic search was conducted in PubMed, Web of Science, SPORTDiscus and Scopus up to December 2025. Eligible studies were conducted in European countries and included children and adolescents aged 6-16 years, using repeated cross-sectional designs and reporting physical fitness components at two or more time points including sample sizes, means and standard deviations. Study quality was assessed with a modified Downs and Black checklist. Data were standardised into z scores based on sample-weighted means and standard deviations, considering the study, physical fitness component, sex and age. Linear mixed models were developed for each physical fitness component to estimate trends (linear, quadratic or cubic) and interactions by sex or age group. RESULTS: Thirty-eight studies were included, representing 417,362 children and adolescents, from 20 European countries between 1965 and 2023. Cardiorespiratory endurance increased until the 1980s, then declined with a deceleration between 2015 and 2023. Body composition decreased linearly up to 2022, more markedly among males. Upper-body strength declined from the 1970s to 2020s, stabilising between the 1980s and 2000s. Lower-body strength increased until the 1980s and declined until 2023. Flexibility declined continuously, with an accelerated decrease after the 2000s. CONCLUSIONS: Health-related components of physical fitness showed persistent declines among European children and adolescents, with differences in the shape and magnitude of trends. These findings highlight the heterogeneity of the available evidence and the need for a standardised, valid and feasible European fitness test battery. Public initiatives should continue to promote adherence to physical activity guidelines, particularly muscle-strengthening recommendations. REGISTRATION: PROSPERO ID: CRD42024609888. CI - (c) 2026. The Author(s). FAU - Domingo-Del-Val, Daniel AU - Domingo-Del-Val D AD - EXER-GENUD (Exercise-Growth, Exercise, Nutrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain. AD - Facultad de Medicina, Departamento de Fisiatria y Enfermeria, Universidad de Zaragoza, Zaragoza, Spain. AD - Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza, 50013, Zaragoza, Spain. AD - Red Espanola de Investigacion en Ejercicio Fisico y Salud, EXERNET, Universidad de Zaragoza, 50009, Zaragoza, Spain. FAU - Lozano-Berges, Gabriel AU - Lozano-Berges G AD - EXER-GENUD (Exercise-Growth, Exercise, Nutrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain. AD - Facultad de Ciencias de la Salud y del Deporte, Departamento de Fisiatria y Enfermeria, Universidad de Zaragoza, Huesca, Spain. AD - Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza, 50013, Zaragoza, Spain. AD - Red Espanola de Investigacion en Ejercicio Fisico y Salud, EXERNET, Universidad de Zaragoza, 50009, Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain. FAU - Moradell, Ana AU - Moradell A AD - EXER-GENUD (Exercise-Growth, Exercise, Nutrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain. AD - Facultad de Ciencias de la Salud y del Deporte, Departamento de Fisiatria y Enfermeria, Universidad de Zaragoza, Huesca, Spain. AD - Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza, 50013, Zaragoza, Spain. AD - Red Espanola de Investigacion en Ejercicio Fisico y Salud, EXERNET, Universidad de Zaragoza, 50009, Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain. FAU - Gomez-Bruton, Alejandro AU - Gomez-Bruton A AD - EXER-GENUD (Exercise-Growth, Exercise, Nutrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain. AD - Facultad de Ciencias de la Salud y del Deporte, Departamento de Fisiatria y Enfermeria, Universidad de Zaragoza, Huesca, Spain. AD - Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza, 50013, Zaragoza, Spain. AD - Red Espanola de Investigacion en Ejercicio Fisico y Salud, EXERNET, Universidad de Zaragoza, 50009, Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain. FAU - Matute-Llorente, Angel AU - Matute-Llorente A AUID- ORCID: 0000-0001-8500-1667 AD - EXER-GENUD (Exercise-Growth, Exercise, Nutrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain. amatute@unizar.es. AD - Facultad de Ciencias de la Salud y del Deporte, Departamento de Fisiatria y Enfermeria, Universidad de Zaragoza, Huesca, Spain. amatute@unizar.es. AD - Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. amatute@unizar.es. AD - Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza, 50013, Zaragoza, Spain. amatute@unizar.es. AD - Red Espanola de Investigacion en Ejercicio Fisico y Salud, EXERNET, Universidad de Zaragoza, 50009, Zaragoza, Spain. amatute@unizar.es. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain. amatute@unizar.es. FAU - Casajus, Jose Antonio AU - Casajus JA AD - EXER-GENUD (Exercise-Growth, Exercise, Nutrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain. AD - Facultad de Medicina, Departamento de Fisiatria y Enfermeria, Universidad de Zaragoza, Zaragoza, Spain. AD - Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza, 50013, Zaragoza, Spain. AD - Red Espanola de Investigacion en Ejercicio Fisico y Salud, EXERNET, Universidad de Zaragoza, 50009, Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain. LA - eng GR - CUS/621/2023/Gobierno de Aragon/ PT - Journal Article PT - Systematic Review DEP - 20260620 PL - Switzerland TA - Sports Med Open JT - Sports medicine - open JID - 101662568 PMC - PMC13283270 OTO - NOTNLM OT - Adolescents OT - Body composition OT - Cardiorespiratory endurance OT - Children OT - Declining trends OT - Europe OT - Flexibility OT - Health-related physical fitness OT - Linear mixed models OT - Strength OT - Systematic review OT - Temporal trends OT - Youth COIS- Declarations. Ethics Approval and Consent to Participate: Not applicable. Consent for Publication: Not applicable. Competing Interests: The authors declare that they have no competing interests. EDAT- 2026/06/21 22:36 MHDA- 2026/06/21 22:37 PMCR- 2026/06/20 CRDT- 2026/06/20 11:16 PHST- 2025/07/09 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/06/21 22:37 [medline] PHST- 2026/06/21 22:36 [pubmed] PHST- 2026/06/20 11:16 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - 10.1186/s40798-026-01032-x [pii] AID - 1032 [pii] AID - 10.1186/s40798-026-01032-x [doi] PST - epublish SO - Sports Med Open. 2026 Jun 20;12(1):77. doi: 10.1186/s40798-026-01032-x. PMID- 42322204 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20261016 IS - 1536-4844 (Electronic) IS - 1078-0998 (Print) IS - 1078-0998 (Linking) VI - 32 IP - 8 DP - 2026 Aug 1 TI - Modified Crohn's Disease Exclusion Diet and exclusive enteral nutrition (EEN) resolve oral dysbiosis in pediatric Crohn's disease: a prospective cohort study. PG - 1587-1599 LID - 10.1093/ibd/izag107 [doi] AB - BACKGROUND AND AIMS: Changes to the oral microbiome have been reported in patients with Crohn's disease (CD). The aim of this study was to determine the characteristics and dynamics of the oral microbiome in children randomized to 1 of 2 nutritional treatments for CD. METHODS: Participants (n = 54) in this randomized controlled trial (NCT02843100) received the Crohn's Disease Exclusion Diet (CDED) with either partial enteral nutrition (PEN; n = 28) or exclusive enteral nutrition (EEN; n = 26). The oral microbiome was assessed via swabs from the dorsum of the tongue and the buccal gingiva by 16S rRNA sequencing at 0, 2, 8, 14, 24, and 52 weeks. RESULTS: There were no significant differences in primary or clinical outcomes between the 2 groups. Due to the COVID-19 pandemic, sampling by 24 weeks was limited to 34 participants. At week 0, moderate-severe disease activity (Pediatric Crohn's Disease Activity Index [PCDAI] > 30) was associated with decreased Porphyromonas, Haemophilus, Alloprevotella, Neisseria, and Bergeyella species and increased Actinomyces. As patients entered remission (PCDAI < 10), we observed a restoration in the abundance of these taxa. A modified oral dysbiosis index (MODI) was generated, capable of distinguishing mild from moderate-severe disease activity based on microbiome profiles. Dysbiosis decreased as treatment continued and patients entered remission. Patients on CDED exhibited more significant dysbiosis index changes at weeks 8-24, compared with the EEN group. Application of the index across published oral microbiome data sets validated its ability to discriminate health from CD. CONCLUSION: Oral microbiome changes in pediatric CD reflect disease activity and parallel therapeutic response to CDED and EEN over time. Additional validation of the proposed dysbiosis index should be undertaken in adequately powered future studies. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. FAU - Moran, Gary P AU - Moran GP AUID- ORCID: 0000-0003-0469-1788 AD - School of Dental Science, Trinity College Dublin and Dublin Dental University Hospital, Dublin D02 F859, Ireland. FAU - McQuillan, Adam AU - McQuillan A AD - School of Dental Science, Trinity College Dublin and Dublin Dental University Hospital, Dublin D02 F859, Ireland. FAU - Ho, Gwo-Tzer AU - Ho GT AUID- ORCID: 0000-0002-6014-372X AD - School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom. FAU - Whelan, Robert J AU - Whelan RJ AD - School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom. FAU - Navas-Lopez, Victor Manuel AU - Navas-Lopez VM AD - Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, Biomedical Research Institute of Malaga (IBIMA), Malaga 29590, Spain. FAU - Lawrence, Sally AU - Lawrence S AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC V6H 3V4, Canada. FAU - Rolandsdotter, Helena AU - Rolandsdotter H AD - Department of Clinical Science and Education, Sodersjukhuset, Karolinska Institutet, 171 77 Stockholm, Sweden. AD - Department of Gastroenterology, Sachs' Children and Youth Hospital, Sodersjukhuset, 118 83 Stockholm, Sweden. FAU - Olen, Ola AU - Olen O AD - Department of Gastroenterology, Sachs' Children and Youth Hospital, Sodersjukhuset, 118 83 Stockholm, Sweden. AD - Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, 171 77 Stockholm, Sweden. FAU - Martin-de-Carpi, Javier AU - Martin-de-Carpi J AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Sant Joan de Deu Barcelona, 08950 Barcelona, Spain. FAU - Sigall Boneh, Rotem AU - Sigall Boneh R AD - Pediatric Gastroenterology and Nutrition Unit, The E. Wolfson Medical Center, Holon, 58100, Israel. FAU - Wine, Eytan AU - Wine E AD - Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada. AD - Department of Physiology, University of Alberta, Edmonton, AB T6G 1C9, Canada. AD - Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto M5G 1X8, Canada. FAU - Hussey, Seamus AU - Hussey S AD - Department of Paediatrics, University of Medicine and Health Sciences, RCSI Dublin and University College Dublin D02 YN77, Ireland. AD - DOCHAS Group, Children's Health Ireland, Dublin D12 N512, Ireland. LA - eng GR - c/18/2/Children's Health Foundation/ GR - NCRC c/18/2/Children's Health Foundation, Dublin, Ireland/ PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Inflamm Bowel Dis JT - Inflammatory bowel diseases JID - 9508162 RN - Pediatric Crohn's disease SB - IM CIN - Inflamm Bowel Dis. 2026 Sep 1;32(9):1864-1865. doi: 10.1093/ibd/izag149. PMID: 42520306 MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Crohn Disease/microbiology/diet therapy/therapy MH - *Dysbiosis/microbiology/therapy/etiology MH - *Enteral Nutrition/methods MH - Microbiota MH - *Mouth/microbiology MH - Prospective Studies PMC - PMC13414547 OTO - NOTNLM OT - Crohn's Disease Exclusion Diet OT - Crohn's disease OT - exclusive enteral nutrition OT - oral microbiome OT - pediatric COIS- The following authors declare these potential conflicts of interest: S.H.-Research grant from Takeda and Janssen in the past 3 years. No conflict for this study. V.M.N.-L.-Consultation fee, research grant, royalties, or honorarium from Ordesa, Adacyte, Nutricia, Pfizer, AbbVie, Takeda, and Nestle Health Science. S.L.-Educational fees from Takeda and McKesson outside the submitted work. H.J.R.-Nutricia, Semper and Adacyte for research support and speaker fee. None of those have any relation to the present study. A.O.-Research support and advisory board for AbbVie, research site for AbbVie, Janssen, Pfizer, Eli Lilly. F.J.M.C.-Honoraria for talks and advisory from Abbvie, Nestle Health Science, MSD, Adacyte, Janssen. O.O.-Dr. Olen has been PI on projects at Karolinska Institutet financed by grants from Janssen, Takeda, AbbVie, Pfizer, Bristol Myers Squibb, and Ferring, and also report grants from Pfizer, AbbVie, Galapagos, and Janssen in the context of national safety monitoring programs. None of those studies have any relation to the present study. J.V.L.-Nestle Health Sciences consulting/research support/speaker fee and Janssen (Research Support/Travel). R.S.B.-Received funds for consulting or speaker-from Nestle Health Science, Takeda, Megapharm and Janssen; serves on advisory board for Evinature. E.W.-Advisory board: AbbVie, Nestle Health Science, Pfizer, BioJamp; Speaker: AbbVie, Nestle Health Science, Janssen, Mead Johnson Nutrition. G.P.M., A.McQ., G.H., and R.J.W., no conflicts to declare. EDAT- 2026/06/21 22:36 MHDA- 2026/07/30 00:38 PMCR- 2026/06/20 CRDT- 2026/06/20 06:52 PHST- 2025/12/15 00:00 [received] PHST- 2026/05/09 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/06/21 22:36 [pubmed] PHST- 2026/06/20 06:52 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - 8712085 [pii] AID - izag107 [pii] AID - 10.1093/ibd/izag107 [doi] PST - ppublish SO - Inflamm Bowel Dis. 2026 Aug 1;32(8):1587-1599. doi: 10.1093/ibd/izag107. PMID- 42321957 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260830 LR - 20260902 IS - 2662-2211 (Electronic) IS - 2662-2211 (Linking) VI - 7 IP - 1 DP - 2026 Jun 19 TI - Roll-Out Implementation Optimization (ROIO) trial to develop and test the implementation of a food security screening and referral process: a study protocol. LID - 10.1186/s43058-026-01025-7 [doi] LID - 171 AB - BACKGROUND: Food insecurity (FI) is associated with poorer physical and mental health outcomes, exacerbation of chronic diseases, and decreased access to healthcare. Children experiencing FI face additional risks, including lower psychosocial functioning and reduced academic achievement. Although national initiatives call for integrating nutrition support services into healthcare, clinical workflows for FI screening and referral remain inconsistently implemented and difficult to sustain. The goal of this study is to refine, adapt, and optimize a comprehensive FI screening and referral program, and identify effective implementation strategies for pediatric healthcare systems. METHODS: We will use a RollOut Implementation and Optimization (ROIO) trial design to iteratively implement and refine the implementation strategies for our FI screening and referral program (I-FRESH: Implementing Food Referrals for Equity and Sustained Health) across 4 pediatric clinics. I-FRESH includes: (1) FI screening; (2) assessment of family needs and readiness to access services; (3) referral and navigation support to community nutrition programs; and (4) follow-up to assess fit, utilization, and ongoing needs. The Pragmatic, Robust Implementation and Sustainability Model (PRISM) will guide adaptation and evaluation of contextual determinants, while RE-AIM will guide assessment of outcomes (implementation feasibility and acceptability, fidelity, adoption, reach, effectiveness, and maintenance). We will identify several implementation strategies to increase the likelihood that I-FRESH can be successfully implemented and sustained in a pediatric healthcare system. We will enroll 240 participants and assess preliminary effectiveness on family‑level food security and pediatric nutrition‑related health outcomes (e.g. weight status, blood pressure, lipids, HbA1c, liver function tests). The information gathered in this trial will be utilized in the development of a fully powered Type 2 Hybrid Effectiveness-Implementation Trial that will test the effectiveness of the identified implementation strategies and impact of the FI program on clinical outcomes. DISCUSSION: By integrating PRISM and RE-AIM within an iterative ROIO design, this study will generate a scalable, contextresponsive implementation model for addressing FI in pediatric healthcare settings. Findings will inform sustainable strategies that link families to highquality nutrition support programs and improve nutritionrelated health outcomes for lowincome children. TRIAL REGISTRATION: NCT06661538. CI - (c) 2026. The Author(s). FAU - Rhee, Kyung E AU - Rhee KE AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. K1rhee@health.ucsd.edu. AD - Rady Children's Health, San Diego, CA, USA. K1rhee@health.ucsd.edu. AD - Department of Pediatrics, UC San Diego School of Medicine, 9500 Gilman Drive, MC 0874, La Jolla, CA, 92093, USA. K1rhee@health.ucsd.edu. FAU - Hiller-Venegas, Sarah AU - Hiller-Venegas S AD - Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA. FAU - Viglione, Clare AU - Viglione C AD - Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA. FAU - Polich, Michelle A AU - Polich MA AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. AD - Rady Children's Health, San Diego, CA, USA. FAU - Huang, Jeannie S AU - Huang JS AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. AD - Rady Children's Health, San Diego, CA, USA. FAU - Kim, Jane J AU - Kim JJ AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. AD - Rady Children's Health, San Diego, CA, USA. FAU - Bajwa, Mandeep S AU - Bajwa MS AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. AD - Rady Children's Health, San Diego, CA, USA. FAU - Zive, Michelle AU - Zive M AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. FAU - Eichen, Dawn M AU - Eichen DM AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. FAU - Strong, David R AU - Strong DR AD - Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA. AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. FAU - Stadnick, Nicole A AU - Stadnick NA AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. AD - UC San Diego ACTRI Dissemination and Implementation Science Center, La Jolla, CA, USA. AD - Child and Adolescent Services Research Center, San Diego, CA, USA. FAU - Brookman-Frazee, Lauren AU - Brookman-Frazee L AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. AD - UC San Diego ACTRI Dissemination and Implementation Science Center, La Jolla, CA, USA. AD - Child and Adolescent Services Research Center, San Diego, CA, USA. LA - eng SI - ClinicalTrials.gov/NCT06661538 GR - R01 DK140573/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260619 PL - England TA - Implement Sci Commun JT - Implementation science communications JID - 101764360 PMC - PMC13528015 OTO - NOTNLM OT - Food insecurity OT - Nutrition insecurity OT - PRISM OT - Pediatrics OT - RE-AIM OT - Roll-Out Implementation and Optimization (ROIO) trial COIS- Declarations. Ethics approval and consent to participate: This study obtained ethics approval from the University of California San Diego Institutional Review Board (protocol # 810869). Consent for publication: Not applicable Competing interests: The authors declare no competing interests. EDAT- 2026/06/20 00:39 MHDA- 2026/06/20 00:40 PMCR- 2026/06/19 CRDT- 2026/06/19 23:53 PHST- 2026/05/01 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/20 00:40 [medline] PHST- 2026/06/20 00:39 [pubmed] PHST- 2026/06/19 23:53 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1186/s43058-026-01025-7 [pii] AID - 1025 [pii] AID - 10.1186/s43058-026-01025-7 [doi] PST - epublish SO - Implement Sci Commun. 2026 Jun 19;7(1):171. doi: 10.1186/s43058-026-01025-7. PMID- 42321828 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1746-4358 (Electronic) IS - 1746-4358 (Linking) VI - 21 IP - 1 DP - 2026 Jun 19 TI - Strengthening breastfeeding counseling through a two-phase training and implementation intervention in Ecuador's local healthcare system. LID - 10.1186/s13006-026-00866-1 [doi] LID - 82 AB - BACKGROUND: Breastfeeding counseling is a key intervention to promote optimal infant feeding, particularly when delivered individually and in person. Its effectiveness depends on the quality of healthcare training, which remains variable. In Ecuador, public services primarily rely on group-based strategies with limited access to individualized support, reinforcing inequalities given the high cost of private services. This study describes an intervention co-developed with the local health system to strengthen provider capacity and implement an individualized counseling model in a rural setting. METHODS: This practice-based case study was conducted in two phases between 2023 and 2024. In Phase I, 32 primary-level healthcare professionals participated in an 80-hour training program combining theoretical and practical components focused on technical skills, communication, and supportive counseling. Focus group discussions informed curriculum adjustments and explored changes in perceptions and competencies. In Phase II, a breastfeeding counseling room was established and staffed by ten trained healthcare professionals. Standardized digital records were used to document user characteristics and consultation topics. Data were analyzed descriptively using Stata and thematically using MAXQDA. RESULTS: Ten of 32 providers (31%) completed the training. A total of 305 counseling sessions were conducted with 247 women, most of whom were lactating (76.5%), aged 18-29 years (68%), and residing in the local catchment area (87.9%). The most frequent consultation topics included breastfeeding technique, nipple pain, perceived low milk supply, and milk expression and storage. Sessions averaged 36 min. Users included adolescents and women with varying levels of maternal experience, highlighting diverse counseling needs. The intervention emphasized individualized, empathetic, and context-sensitive support. CONCLUSIONS: The intervention was feasible within a public primary healthcare setting and addressed key gaps in access to individualized breastfeeding support. It demonstrated the relevance of combining technical and relational competencies in counseling and the importance of integrating such services within existing health systems. These findings provide practical insights for the implementation of similar models in resource-constrained settings. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Orozco, Fadya AU - Orozco F AUID- ORCID: 0000-0002-5743-6898 AD - Centro de Transferencia de Tecnologia CTT-USFQ, Universidad San Francisco de Quito USFQ, Quito, Ecuador. orozcofadya@gmail.com. AD - Fundacion Tejiendo Maternidades e Infancias - TEMI, Quito, Ecuador. orozcofadya@gmail.com. FAU - Herrera-Fontana, Maria Elisa AU - Herrera-Fontana ME AD - Universidad San Francisco de Quito USFQ, Quito, Ecuador. FAU - Montenegro, Stephanie AU - Montenegro S AD - Centro de Transferencia de Tecnologia CTT-USFQ, Universidad San Francisco de Quito USFQ, Quito, Ecuador. AD - Fundacion Tejiendo Maternidades e Infancias - TEMI, Quito, Ecuador. FAU - Munoz, Fabian AU - Munoz F AD - Visor Analisis Estadistico Cia. Ltda., Quito, Ecuador. FAU - Molina, Johanna AU - Molina J AD - DP17-Oficina Tecnica 17-OT 10 Cayambe - PedroMoncayo, Cayambe, Ecuador. FAU - Chicaiza, Alicia AU - Chicaiza A AD - DP17-Oficina Tecnica 17-OT 10 Cayambe - PedroMoncayo, Cayambe, Ecuador. FAU - Handal, Alexis J AU - Handal AJ AD - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA. LA - eng GR - R01 ES026603/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20260619 PL - England TA - Int Breastfeed J JT - International breastfeeding journal JID - 101251562 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Ecuador MH - *Counseling/education/methods MH - Female MH - Adult MH - *Health Personnel/education MH - Young Adult MH - Adolescent MH - Infant MH - Infant, Newborn PMC - PMC13536587 OTO - NOTNLM OT - Breastfeeding OT - Breastfeeding counseling OT - Educational intervention OT - Healthcare professionals OT - Training COIS- Declarations. Ethics approval and consent to participate: The course of the intervention had the ethical approval of the Ethical Committee for Research in Humans of Universidad San Francisco de Quito (CEISH, ID 2017-177IN; approved February 8, 2018) within the framework of the SEMILLA study. Likewise, District Health Division 17D10 (Cayambe-Pedro Moncayo) authorized its implementation in the study area. All the focus groups participants gave their oral consent in advance. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/20 00:38 MHDA- 2026/09/02 05:36 PMCR- 2026/06/19 CRDT- 2026/06/19 23:49 PHST- 2025/12/12 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/20 00:38 [pubmed] PHST- 2026/06/19 23:49 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1186/s13006-026-00866-1 [pii] AID - 866 [pii] AID - 10.1186/s13006-026-00866-1 [doi] PST - epublish SO - Int Breastfeed J. 2026 Jun 19;21(1):82. doi: 10.1186/s13006-026-00866-1. PMID- 42321687 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1471-2415 (Electronic) IS - 1471-2415 (Linking) VI - 26 IP - 1 DP - 2026 Jun 19 TI - Agreement between Pentacam HR and Visionix VX650 system for corneal and anterior chamber parameters. LID - 10.1186/s12886-026-05054-7 [doi] LID - 534 AB - PURPOSE: To evaluate the agreement in anterior segment measurements obtained with Pentacam HR and Visionix VX650 topographers, in terms of keratometry, pachymetry and anterior chamber parameters in healthy eyes. METHODS: Inclusion criteria consisted of healthy eyes with no history of ocular pathology or surgery. Measurements of central corneal thickness (CCT), minimum corneal thickness (MCT), anterior and posterior keratometry (K1, K2), anterior chamber depth (ACD), and anterior chamber angle (ACA) were taken using the Pentacam HR and Visionix VX650. Differences between devices were assessed with paired Student's t-tests, and agreement was evaluated using Bland-Altman plots. RESULTS: Fifty-five eyes from 55 healthy participants mean age 32.55 +/- 12.60 years) were examined. Anterior keratometry and MCT showed clinically acceptable agreement between devices, with no significant differences (p > 0.164). Pentacam HR reported steeper posterior keratometry, smaller ACD, lower CCT and larger ACA values compared with VX650 (p < 0.001). For CCT and MCT, ranges of agreement were large, with values of +/- 27.07 and 55.41 mum, respectively. However, the ranges of agreement for anterior K1 and K2 were smaller, with values of +/- 0.11 and 0.11 mm, respectively. Likewise, the ranges of agreement for ACD and ACA were also clinically significant, with a clear trend of VX650 to provide longer ACD measurements and lower ACA estimates. CONCLUSIONS: Anterior corneal keratometry measured with the Pentacam HR and Visionix VX650 exhibit acceptable inter-device agreement. However, caution should be exercised regarding their interchangeability, especially when making decisions that require precise thickness (refractive surgery screening) or anterior chamber parameters (phakic intraocular lens implantation). CI - (c) 2026. The Author(s). FAU - Barberan-Bernardos, Laura AU - Barberan-Bernardos L AD - Department of Optics, Pharmacology and Anatomy, University of Alicante, Crta San Vicente del Raspeig s/n, San Vicente del Raspeig, Alicante, 03016, Spain. FAU - Ariza-Gracia, Miguel Angel AU - Ariza-Gracia MA AD - ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. FAU - Pinero, David P AU - Pinero DP AD - Department of Optics, Pharmacology and Anatomy, University of Alicante, Crta San Vicente del Raspeig s/n, San Vicente del Raspeig, Alicante, 03016, Spain. david.pinyero@ua.es. AD - Department of Ophthalmology (IMQO-Oftalmar), Vithas Medimar International Hospital, Alicante, Spain. david.pinyero@ua.es. LA - eng GR - CIACIF/2022/073/Generalitat Valenciana/ PT - Comparative Study PT - Journal Article DEP - 20260619 PL - England TA - BMC Ophthalmol JT - BMC ophthalmology JID - 100967802 SB - IM MH - Humans MH - *Corneal Topography/instrumentation MH - *Anterior Chamber/anatomy & histology MH - Female MH - Adult MH - *Cornea/anatomy & histology MH - Male MH - Corneal Pachymetry/instrumentation MH - Middle Aged MH - Young Adult MH - Reproducibility of Results MH - Healthy Volunteers MH - Adolescent MH - Prospective Studies PMC - PMC13536767 OTO - NOTNLM OT - Anterior segment imaging OT - Corneal topography OT - Keratometry OT - Pachymetry OT - Pentacam HR OT - Visionix VX650 COIS- Declarations. Ethical approval: The study followed the tenets of the Declaration of Helsinki and was approved by the ethics committee of the University of Alicante (UA-2023-01-19_2). Consent to participate: All recruited patients were informed about the nature of the study and provided written informed consent prior to their inclusion. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/20 00:38 MHDA- 2026/09/02 05:36 PMCR- 2026/06/19 CRDT- 2026/06/19 23:45 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/20 00:38 [pubmed] PHST- 2026/06/19 23:45 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1186/s12886-026-05054-7 [pii] AID - 5054 [pii] AID - 10.1186/s12886-026-05054-7 [doi] PST - epublish SO - BMC Ophthalmol. 2026 Jun 19;26(1):534. doi: 10.1186/s12886-026-05054-7. PMID- 42321595 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 10 DP - 2026 Oct TI - Comparative Properties of Two Self-Report Measures of Avoidant/Restrictive Food Intake Disorder: Psychometric and Clinical Utility. PG - 2226-2236 LID - 10.1002/eat.70151 [doi] AB - OBJECTIVES: We compared two measures of Avoidant/Restrictive Food Intake Disorder (ARFID)-the NIAS and the PARDI-AR-Q to determine which demonstrates better psychometric and clinical utility. METHODS: The study was pre-registered (OSF; DOI 10.17605/OSF.IO/N8WBF). Participants (aged >/= 18 years, BMI > 18.5) were recruited via Prolific and screened via a short written description of their fussy eating behaviors. After review, eligible participants (N = 156) were invited to complete a second online survey, consisting of the NIAS, PARDI-AR-Q, GAD-7, PHQ-9, CIA, and EDE-Q7. Exploratory factor analyses were conducted separately for the NIAS and PARDI-AR-Q dimensions, and then on combined items. Pearson's correlations examined associations within and across both ARFID measures. Categorical agreement between measures was examined. Correlations and multiple regressions determined the extent to which ARFID subscales accounted for variance across the broader clinical outcomes. RESULTS: All subscales within and across the NIAS and PARDI-AR-Q were significantly and positively correlated. The weakest association was observed between the NIAS Picky Eating subscale and the PARDI-AR-Q Sensory Sensitivity subscale-a pattern supported by the combined exploratory factor analysis, which yielded a four-factor model. The NIAS and PARDI-AR-Q showed significant, moderate case agreement. The PARDI-AR-Q showed much stronger evidence of clinical validity. DISCUSSION: Overall, the PARDI-AR-Q demonstrated greater clinical validity than the NIAS. The weak association between Picky Eating and Sensory Sensitivity suggests these measures capture distinct behavioral and motivational components of ARFID. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Nicholls-Clow, Rebecca AU - Nicholls-Clow R AUID- ORCID: 0009-0007-9941-5415 AD - School of Psychology, University of Sheffield, Sheffield, UK. FAU - Prudenzi, Arianna AU - Prudenzi A AUID- ORCID: 0000-0002-5185-2807 AD - School of Psychology, University of Sheffield, Sheffield, UK. FAU - Waller, Glenn AU - Waller G AUID- ORCID: 0000-0001-7794-9546 AD - Department of Psychology, University of Warwick, Coventry, UK. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260619 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Psychometrics MH - Female MH - Adult MH - Male MH - *Self Report MH - *Avoidant Restrictive Food Intake Disorder/diagnosis/psychology MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Middle Aged MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Factor Analysis, Statistical PMC - PMC13655934 OTO - NOTNLM OT - Avoidant/Restrictive Food Intake Disorder (ARFID) OT - NIAS OT - PARDI-AR-Q OT - clinical utility OT - eating disorders OT - psychometrics OT - self-report measures COIS- The authors declare no conflicts of interest. EDAT- 2026/06/20 00:37 MHDA- 2026/10/12 11:41 PMCR- 2026/10/12 CRDT- 2026/06/19 23:26 PHST- 2026/04/29 00:00 [revised] PHST- 2026/02/26 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/06/20 00:37 [pubmed] PHST- 2026/06/19 23:26 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - EAT70151 [pii] AID - 10.1002/eat.70151 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Oct;59(10):2226-2236. doi: 10.1002/eat.70151. Epub 2026 Jun 19. PMID- 42321360 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20261007 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 19 TI - Medicine ball throw distance weighted with height-to-mass ratio aligns with other physical fitness tasks. LID - 10.1038/s41598-026-58353-w [doi] LID - 28114 AB - The traditional Medicine Ball Throw (MBT(T)) for assessing upper-extremity explosive strength inherently favours heavier and taller participants. We designed three alternative indices to adjust for this anthropometric bias: (1) multiplying MBT(T) by the height-to-mass ratio (MBT(A1)), (2) dividing MBT(T) by the product of mass and height (MBT(A2)), and (3) dividing MBT(T) by the body mass index (MBT(A3)). Using age- and sex-adjusted LMS-based z-scores from two independent cohorts (821 children, aged 8.3 +/- 0.7 years; 354 adolescents, aged 14.4 +/- 2.2 years), we compared the variants' alignment with the concave BMI-profiles of five standard fitness tests (6-minute run, standing long jump, jump sideways, 4 x 10 m shuttle run, push-ups). The three anthropometrically enriched variants yielded significantly better goodness of fit than MBT(T) with MBT(A1) performing best overall. Furthermore, when deployed as independent covariates, the enriched indices demonstrated systematically higher predictive power for standard fitness tasks than the unadjusted distance. We recommend adjusting MBT(T) via the height-to-mass ratio for a fairer assessment, though its structural overlap with BMI requires caution in predictive models. CI - (c) 2026. The Author(s). FAU - Jarnig, Gerald AU - Jarnig G AUID- ORCID: 0000-0003-0885-5866 AD - Department of Human Movement Science, Sport and Health, University of Graz, Mozartgasse 14, Graz, Austria. gerald.jarnig@uni-graz.at. FAU - Kliegl, Reinhold AU - Kliegl R AUID- ORCID: 0000-0002-0180-8488 AD - Department of Sports and Health Sciences, Division of Training and Movement Sciences, University of Potsdam, Potsdam, Germany. FAU - Kerbl, Reinhold AU - Kerbl R AUID- ORCID: 0009-0007-3567-2877 AD - Department of Pediatrics and Adolescent Medicine, LKH Hochsteiermark, Leoben, Austria. FAU - van Poppel, Mireille N M AU - van Poppel MNM AUID- ORCID: 0000-0001-5694-4324 AD - Department of Human Movement Science, Sport and Health, University of Graz, Mozartgasse 14, Graz, Austria. LA - eng GR - GZ:2025-0.021.608/Austrian Federal Ministry for Arts, Culture, Civil Service and Sport/ GR - GZ:2024-0.780.614/Austrian Federal Ministry of Education, Science and Research/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260619 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Physical Fitness/physiology MH - Body Mass Index MH - Adolescent MH - Female MH - Male MH - Child MH - *Body Height MH - Exercise Test/methods MH - Anthropometry PMC - PMC13554187 OTO - NOTNLM OT - Anthropometry OT - Athletic performance OT - Height-to-mass ratio OT - Medicine ball throw OT - Model validation OT - Physical fitness OT - Upper body strength COIS- Declarations. Competing interests: The authors declare no competing interests. Institutional review board: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Research Ethics Committee of the University of Graz, Styria, Austria (GZ. 39/68/63 ex 2021/22). Informed consent: Informed consent was obtained from all the subjects involved in the study. EDAT- 2026/06/20 00:37 MHDA- 2026/09/09 07:07 PMCR- 2026/06/19 CRDT- 2026/06/19 23:20 PHST- 2026/02/07 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/20 00:37 [pubmed] PHST- 2026/06/19 23:20 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1038/s41598-026-58353-w [pii] AID - 58353 [pii] AID - 10.1038/s41598-026-58353-w [doi] PST - epublish SO - Sci Rep. 2026 Jun 19;16(1):28114. doi: 10.1038/s41598-026-58353-w. PMID- 42321344 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20261005 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 19 TI - Associations of lifestyle and biological factors with body image among reproductive-aged women: a cross-sectional study. LID - 10.1038/s41598-026-56798-7 [doi] LID - 28125 AB - This study aimed to identify lifestyle and biological factors associated with body image among reproductive-aged women, focusing on physical activity, sedentary time, sleep, BMI, premenstrual symptoms (PMS), and sleep quality. A secondary aim was to explore interrelationships among these factors to contextualise their combined association with body image. In this cross-sectional online survey, 291 women aged 18-45 years participated (mean age: 27.16 +/- 0.36 years). Validated questionnaires were used to assess body image (Body Appreciation Scale), physical activity (Global Physical Activity Questionnaire), sleep quality (Sleep Quality Scale), BMI, and PMS (Premenstrual Assessment Form-Short Form). Data were analysed with IBM SPSS 28.0 using multivariable linear regression and correlation analyses (p < 0.05). Higher BMI, greater PMS severity, poorer sleep quality and longer sedentary time were significantly associated with lower body appreciation. Correlations were found between PMS and sleep quality (r = 0.309; p < 0.001), PMS and work-related moderate activity (r = 0.119; p = 0.043), and sleep quality and work-related moderate activity (r = 0.169; p = 0.004). No significant associations were observed for recreational physical activity with PMS (r=-0.041; p = 0.544) or sleep quality (r=-0.040; p = 0.498). Body image in reproductive-aged women was associated with both lifestyle behaviours and biological symptom burden. The findings suggest that supporting positive body image may benefit from integrated approaches addressing sedentary behaviour, sleep quality and menstrual health alongside weight-related factors. CI - (c) 2026. The Author(s). FAU - Dozsa-Juhasz, Olivia AU - Dozsa-Juhasz O AD - Institute of Physiotherapy and Sport Science, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. FAU - Premusz, Viktoria AU - Premusz V AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. FAU - Acs, Pongrac AU - Acs P AD - Physical Activity Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary. FAU - Hock, Marta AU - Hock M AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. FAU - Makai, Alexandra AU - Makai A AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. alexandra.makai@etk.pte.hu. LA - eng PT - Journal Article DEP - 20260619 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Adult MH - Cross-Sectional Studies MH - *Body Image/psychology MH - *Life Style MH - Middle Aged MH - Body Mass Index MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Exercise MH - Sleep Quality MH - Sedentary Behavior MH - Premenstrual Syndrome/psychology MH - Sleep MH - Body Satisfaction PMC - PMC13554112 OTO - NOTNLM OT - 24-hour movement behaviours OT - Body image OT - Premenstrual syndrome OT - Sleep quality OT - Women's health COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The study was registered by the U.S. National Institute of Health (clinicaltrial.gov, Identifier: NCT06146673; date of registration: 23/11/2023) and approved by the Medical Research Council of Hungary (Identifier: BM/23899-1/2023). A research protocol adhering to the principles of the Helsinki Declaration was followed. Participants provided voluntary, uninfluenced consent for the anonymous use and publication of their data following appropriate information provision. EDAT- 2026/06/20 00:38 MHDA- 2026/09/09 07:07 PMCR- 2026/06/19 CRDT- 2026/06/19 23:19 PHST- 2025/11/04 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/20 00:38 [pubmed] PHST- 2026/06/19 23:19 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1038/s41598-026-56798-7 [pii] AID - 56798 [pii] AID - 10.1038/s41598-026-56798-7 [doi] PST - epublish SO - Sci Rep. 2026 Jun 19;16(1):28125. doi: 10.1038/s41598-026-56798-7. PMID- 42320787 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260923 IS - 1559-2030 (Electronic) IS - 1551-7144 (Print) IS - 1551-7144 (Linking) VI - 168 DP - 2026 Sep TI - Protocol for a randomized, controlled trial of a bioactive dietary polyphenol preparation to promote resilience in healthy individuals. PG - 108382 LID - S1551-7144(26)00168-0 [pii] LID - 10.1016/j.cct.2026.108382 [doi] AB - Botanicals and nutritional supplements have gained tremendous popularity as natural approaches to enhancing physical and mental health. However, alongside this trend, there is a growing recognition of the importance of rigorous human studies to validate the absorption, bioavailability, safety and physiological effects of these botanicals. Understanding the effects of these compounds on stress-related outcomes is crucial for ensuring their efficacy and safety to promote stress resilience and overall health. This report describes the design of a parallel arm, randomized, double-blind, placebo-controlled clinical trial to assess the absorption and bioavailability of a 5-week intervention of a daily Bioactive Dietary Polyphenol Preparation (BDPP) consisting of Concord grape juice (CGJ), grape seed polyphenol extract (GSPE), and trans-resveratrol (RSV). Healthy adults (ages 18-55 years) are randomized to receive low, medium, or high doses of BDPP or matching placebo. In addition to pharmacokinetic profiling, the study will evaluate the effects of BDPP on immune function and behavioral measures of stress. The trier social stress test (TSST) will probe acute response to stress. Findings from this trial are intended to lay the foundation for future, larger studies of BDPP and other natural polyphenol-rich products investigating the clinical utility of phenolic supplements for stress resilience and health. CI - Published by Elsevier Inc. FAU - Marchidan, M M AU - Marchidan MM AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Rizk, M M AU - Rizk MM AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Karpman, E AU - Karpman E AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Lizzano, A AU - Lizzano A AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Fremont, R AU - Fremont R AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Dobbs, M F AU - Dobbs MF AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Lee, J H AU - Lee JH AD - Centers for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Irizar, H AU - Irizar H AD - Centers for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Lyu, W AU - Lyu W AD - New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and the Rutgers Core Facility for Natural Products and Bioanalysis, New Brunswick, NJ, United States; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States. FAU - Yin, Z AU - Yin Z AD - New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and the Rutgers Core Facility for Natural Products and Bioanalysis, New Brunswick, NJ, United States. FAU - Wu, Q AU - Wu Q AD - New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and the Rutgers Core Facility for Natural Products and Bioanalysis, New Brunswick, NJ, United States; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States. FAU - Simon, J E AU - Simon JE AD - New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and the Rutgers Core Facility for Natural Products and Bioanalysis, New Brunswick, NJ, United States; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States. FAU - Ferruzzi, M AU - Ferruzzi M AD - Department of Food, Bioprocessing and Nutrition Sciences, Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, United States. FAU - Pasinetti, G M AU - Pasinetti GM AD - Geriatrics Research, Education and Clinical Center (GRECC), James J. Peters VA Medical Center, Bronx, NY, United States; The Bronx Veterans Medical Research Foundation, Bronx, NY, USA; VA Sequencing Collaborations United for Research and Epidemiology (seqCURE), James J. Peters VA Medical Center, Bronx, NY, USA. Electronic address: giulio.pasinetti@va.gov. FAU - Murrough, J W AU - Murrough JW AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States; VISN 2 Mental Illness Research, Education, and Clinical Centers (MIRECC), James J. Peters VA Medical Center, Bronx, New York, United States. Electronic address: james.murrough@mssm.edu. LA - eng GR - R01 MH104559/MH/NIMH NIH HHS/United States GR - U19 AT010835/AT/NCCIH NIH HHS/United States GR - UL1 TR004419/TR/NCATS NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260619 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 RN - 0 (Grape Seed Extract) RN - 0 (Polyphenols) RN - Q369O8926L (Resveratrol) RN - 0 (Stilbenes) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Biological Availability MH - Dietary Supplements MH - Double-Blind Method MH - Fruit and Vegetable Juices MH - *Grape Seed Extract/pharmacokinetics/administration & dosage MH - *Polyphenols/pharmacokinetics/administration & dosage MH - Research Design MH - *Resilience, Psychological MH - Resveratrol MH - *Stilbenes/pharmacokinetics MH - *Stress, Psychological/drug therapy PMC - PMC13405406 MID - NIHMS2194333 OTO - NOTNLM OT - Clinical trial OT - Complementary and alternative medicine OT - Immune system OT - Inflammation OT - Methodology OT - Polyphenols OT - Stress COIS- Declaration of competing interest Mario G. Ferruzzi reports funding provided by NIH-NCCIH. MGF serves as a trustee/director on the boards of non-profit societies the Institute for the Advancement of Food and Nutrition Sciences and the International Food Information Council. MGF serves as a member of the board of directors for Sensient Technologies which manufactures food ingredients including flavors and colors If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. James E. Simon reports funds from the New Jersey Agricultural Experiment Station (NJAES) via a 5-year HATCH project #NJ12170; Accession #1025914 which supports a broad range of research with natural products and health and at times some lab supplies in support of this project were purchased. James W. Murrough is a full-time employee of the Icahn School of Medicine at Mount Sinai and a part-time employee of the U.S. Department of Veterans Affairs. In the past 36 months, Dr. Murrough has provided paid consultation services for Acadia Pharmaceuticals, Autobahn Therapeutics, Inc., Biohaven Pharmaceuticals, Inc., Clexio Biosciences, Definium Therapeutics, Frontier Pharma, LLC, HMP Collective, Janssen Pharmaceuticals, Merck & Co., Inc., Otsuka Pharmaceutical, Ltd, WCG Clinical, and Inc., Xenon Pharmaceuticals, Inc. Dr. Murrough is a named inventor on patent applications filed by the Icahn School of Medicine at Mount Sinai covering methods for the treatment of mood and anxiety disorders, including approaches involving KCNQ channel openers, psychedelic compounds, immunotherapeutic strategies, and digital/sensor-based interventions for emotion regulation. None of these applications has been issued as a patent or licensed, and Dr. Murrough has received no royalties or financial benefit from them. All other authors report no conflicts of interest. EDAT- 2026/06/20 00:39 MHDA- 2026/08/12 23:34 PMCR- 2026/07/28 CRDT- 2026/06/19 19:36 PHST- 2025/03/01 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/08/12 23:34 [medline] PHST- 2026/06/20 00:39 [pubmed] PHST- 2026/06/19 19:36 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - S1551-7144(26)00168-0 [pii] AID - 10.1016/j.cct.2026.108382 [doi] PST - ppublish SO - Contemp Clin Trials. 2026 Sep;168:108382. doi: 10.1016/j.cct.2026.108382. Epub 2026 Jun 19. PMID- 42319240 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 1758-2652 (Electronic) IS - 1758-2652 (Linking) VI - 29 Suppl 1 IP - Suppl 1 DP - 2026 Jun TI - Optimizing Identification and Care of Pregnant/Breastfeeding Women Living With HIV in Resource-Limited Settings. PG - e70126 LID - 10.1002/jia2.70126 [doi] LID - e70126 AB - INTRODUCTION: Since the mid-1990s, there have been major advances in diagnosing and providing antiretroviral therapy (ART) for pregnant women living with HIV (WLWH) in both resource-rich and resource-limited settings. Initial progress was based on the 1994 landmark perinatal trial, which showed 67% reduction in vertical transmission among infants born to non-breastfeeding mothers in the United States when zidovudine was given during pregnancy, at labour/delivery and for 6 weeks after birth. International perinatal trials began testing "short-course" zidovudine regimens during late pregnancy and at labour/delivery to develop cost-effective, feasible and deliverable interventions for low-resource environments. More recent research has focused on the delivery of cost-effective combination triple ART during pregnancy and breastfeeding for WLWH. The latest trial results indicate that providing lifetime maternal ART at the time of antenatal diagnosis improves overall survival and decreases morbidity, while reducing vertical transmission to <1%. DISCUSSION: Translation of clinical trial results into successful widescale programme implementation remains a major challenge, particularly in low- and middle-income countries with high HIV seroprevalence and weak maternal and child health infrastructure. Interventions recommended earlier in the global epidemic are no longer adequate, but key points of the perinatal cascade of services remain crucial to both ensure successful HIV care for WLWH and maximize reductions in vertical transmission. Notable progress made in Botswana and Uganda is valuable to highlight country-led successes. Rapid HIV testing for pregnant women whose status is unknown, followed by immediate implementation of lifetime maternal ART, and linkage to long-term HIV care/treatment are essential. Counselling on adherence, as well as the use of long-acting ART regimens and holistic support for women's care, including psychosocial support, are also needed. A current major challenge has been the sudden reduction in international donor funding, which has had a significant negative impact on continuity and effective delivery of HIV care/treatment services. CONCLUSIONS: Much progress has been made in advancing HIV interventions and programmes for WLWH and pregnant and breastfeeding mothers. However, several challenges persist, which compromise delivery of effective interventions on the path to eliminate perinatal HIV transmission, and care/treatment remains suboptimal for WLWH, especially in resource-limited settings. CI - (c) 2026 The Author(s). Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. FAU - Fowler, Mary Glenn AU - Fowler MG AUID- ORCID: 0000-0003-4484-9009 AD - Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. FAU - Chou, Victoria B AU - Chou VB AUID- ORCID: 0000-0003-3215-5544 AD - Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Musoke, Philippa AU - Musoke P AD - MU-JHU Research Collaboration, Kampala, Uganda. LA - eng PT - Journal Article PL - Switzerland TA - J Int AIDS Soc JT - Journal of the International AIDS Society JID - 101478566 RN - 0 (Anti-HIV Agents) SB - IM MH - Female MH - Humans MH - Pregnancy MH - Anti-HIV Agents/therapeutic use MH - *Breast Feeding MH - *HIV Infections/diagnosis/drug therapy MH - *Infectious Disease Transmission, Vertical/prevention & control MH - *Pregnancy Complications, Infectious/diagnosis/drug therapy MH - *Resource-Limited Settings PMC - PMC13281401 COIS- The authors have no conflicts of interest to disclose. EDAT- 2026/06/19 12:37 MHDA- 2026/06/19 12:38 PMCR- 2026/06/19 CRDT- 2026/06/19 09:24 PHST- 2026/05/10 00:00 [revised] PHST- 2025/12/03 00:00 [received] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/19 12:38 [medline] PHST- 2026/06/19 12:37 [pubmed] PHST- 2026/06/19 09:24 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - JIA270126 [pii] AID - 10.1002/jia2.70126 [doi] PST - ppublish SO - J Int AIDS Soc. 2026 Jun;29 Suppl 1(Suppl 1):e70126. doi: 10.1002/jia2.70126. PMID- 42318828 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260827 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Adolescent Acceptability of School and Home Micronutrient Supplementation and Nutrition Curriculum in Mozambique. PG - e70211 LID - 10.1111/mcn.70211 [doi] LID - e70211 AB - Iron-deficiency anemia is the most common micronutrient deficiency and a leading cause of disability-adjusted life years among adolescent girls and young women (AGYW) globally. Although multiple micronutrient supplementation (MMS) provides a broader range of micronutrients than iron-folic acid supplementation (IFAS) prior to conception, the acceptability of MMS and home-based supplementation strategies remains underexplored. We assessed the acceptability of MMS, IFAS, and a contextualized nutrition curriculum delivered via school clubs in a two-arm cluster-randomized trial across three rural secondary schools in Monapo District, Mozambique. Fourteen teachers (clusters) were randomized to deliver either weekly school-based IFAS or daily home-based MMS. A total of 492 AGYW aged 13-20 years were enrolled (240 IFAS; 252 MMS); both arms received the same nutrition curriculum. Participants in both arms reported increased energy, improved appetite, and relief from menstrual symptoms. IFAS was significantly more acceptable than MMS for smell, and some participants perceived the once-weekly IFAS regimen as less burdensome than daily MMS. Some AGYW also reported that male peers perceived MMS as birth control, or assumed the girls were pregnant, due to the image of a pregnant woman on the pill bottle. Ratings of the nutrition curriculum and teachers' facilitation were positive in both arms. Participants generally preferred the regimen they were assigned, and family support facilitated adherence. These findings suggest home-based supplementation may be a feasible and acceptable strategy for reaching in-school and out-of-school AGYW in Mozambique. Including boys in future interventions and redesigning the MMS label could help reduce misconceptions and enhance acceptability. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Bauler, Sarah AU - Bauler S AUID- ORCID: 0000-0001-6911-8021 AD - World Vision International, London, England, UK. AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - George, Christine Marie AU - George CM AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Leontsini, Elli AU - Leontsini E AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Mandlate, Mateus AU - Mandlate M AD - World Vision Mozambique, Monapo, Nampula Province, Mozambique. FAU - Gittelsohn, Joel AU - Gittelsohn J AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Perin, Jamie AU - Perin J AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Kirwa, Titus AU - Kirwa T AD - World Vision International, London, England, UK. FAU - Tse, Carmen AU - Tse C AD - World Vision International, London, England, UK. FAU - Bernardo, Tui AU - Bernardo T AD - World Vision Mozambique, Monapo, Nampula Province, Mozambique. FAU - Davis, Tom AU - Davis T AD - Global Health Consultant, Torrevieja, Alicante, Spain. FAU - Tolossa, Asrat Dibaba AU - Tolossa AD AD - World Vision Canada, Toronto, Ontario, Canada. FAU - Dias, Antonio Santana AU - Dias AS AD - World Vision International, London, England, UK. FAU - Wong, Julianne AU - Wong J AD - World Vision International, London, England, UK. FAU - Moises, Lucilia AU - Moises L AD - World Vision Mozambique, Monapo, Nampula Province, Mozambique. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 RN - 0 (Micronutrients) RN - 935E97BOY8 (Folic Acid) SB - IM MH - Humans MH - *Dietary Supplements MH - Female MH - Mozambique MH - Adolescent MH - *Micronutrients/administration & dosage MH - Young Adult MH - Male MH - Curriculum MH - *Anemia, Iron-Deficiency/prevention & control MH - Schools MH - *Patient Acceptance of Health Care MH - Rural Population MH - Folic Acid/administration & dosage PMC - PMC13280799 OTO - NOTNLM OT - Mozambique OT - acceptability OT - adolescent anemia OT - multiple micronutrient supplementation OT - nutrition curriculum OT - supplement COIS- The authors declare no conflicts of interest. EDAT- 2026/06/19 12:36 MHDA- 2026/06/19 12:37 PMCR- 2026/06/19 CRDT- 2026/06/19 06:33 PHST- 2026/05/08 00:00 [revised] PHST- 2025/09/01 00:00 [received] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/06/19 12:37 [medline] PHST- 2026/06/19 12:36 [pubmed] PHST- 2026/06/19 06:33 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - MCN70211 [pii] AID - 10.1111/mcn.70211 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70211. doi: 10.1111/mcn.70211. PMID- 42318005 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Machine learning-based prediction models for severe Mycoplasma pneumoniae pneumonia in Chinese children: a systematic review and meta-analysis of prediction model performance. PG - 1793116 LID - 10.3389/fpubh.2026.1793116 [doi] LID - 1793116 AB - OBJECTIVES: This study aimed to systematically evaluate the predictive performance and methodological characteristics of machine learning-based models for predicting progression to severe Mycoplasma pneumoniae pneumonia (SMPP) in pediatric patients. METHODS: A comprehensive literature search was conducted in PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, and Wanfang databases from inception to November 2025 to identify studies developing or validating prediction models for SMPP in children. Data on study characteristics, modeling algorithms, predictors, and performance metrics were extracted. A narrative synthesis was performed to summarize model characteristics, predictors, and modeling approaches, while model discrimination was quantitatively synthesized using pooled area under the receiver operating characteristic curve (AUC). Subgroup analyses were conducted according to modeling algorithms. Methodological quality and risk of bias were assessed using the PROBAST tool. RESULTS: A total of 13 studies were included. The reported prevalence of hypoglycemia ranged from 17 to 33%. The AUC for predictive models ranged from 0.81 to 0.90. Subgroup analyses showed that machine learning-based models such as XGBoost and random forest generally reported higher AUC values compared with other modeling approaches. Commonly reported predictors included age, insulin use, body mass index, HbA1c, creatinine, and history of hypoglycemia. CONCLUSION: Research on risk prediction models for SMPP in children is still at a developmental stage. Although current models demonstrate high discriminatory performance, methodological limitations and limited clinical translation remain. Future studies should focus on developing robust, interpretable machine learning models and facilitating their integration into pediatric clinical practice. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/ CRD42020190338. CI - Copyright (c) 2026 Cao, Nie, Wu and Liu. FAU - Cao, Juan AU - Cao J AD - College of Medicine and Health Sciences, China Three Gorges University, Yichang, Hubei, China. FAU - Nie, Jiao AU - Nie J AD - Department of Nursing, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China. FAU - Wu, Danxia AU - Wu D AD - Department of Respiratory Medicine, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China. FAU - Liu, Huiqin AU - Liu H AD - The First College of Clinical Medicine, China Three Gorges University, Yichang Central People's Hospital, Yichang, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260603 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Child MH - Humans MH - Boosting Machine Learning Algorithms MH - China/epidemiology MH - *Machine Learning MH - Mycoplasma pneumoniae MH - *Pneumonia, Mycoplasma/diagnosis/epidemiology MH - Predictive Learning Models MH - East Asian People PMC - PMC13272165 OTO - NOTNLM OT - machine learning OT - meta-analysis OT - pediatrics OT - prediction model OT - severe Mycoplasma pneumoniae pneumonia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/19 06:32 MHDA- 2026/06/19 06:33 PMCR- 2026/06/03 CRDT- 2026/06/19 04:53 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/19 06:33 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 04:53 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1793116 [doi] PST - epublish SO - Front Public Health. 2026 Jun 3;14:1793116. doi: 10.3389/fpubh.2026.1793116. eCollection 2026. PMID- 42317576 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260619 LR - 20260813 IS - 2753-6130 (Electronic) IS - 2753-6130 (Linking) VI - 15 DP - 2026 Jan-Dec TI - Increasing Physical, Emotional, and Social Wellbeing in Adolescents Following a Multi-Week Indian Classical Dance Program: Results From a Single-Arm Pilot Study. PG - 27536130261459352 LID - 10.1177/27536130261459352 [doi] LID - 27536130261459352 AB - BACKGROUND: The physical, emotional, and social wellbeing of U.S. high school-aged adolescents is a growing public health concern. OBJECTIVE: To describe the development and initial effects of an 8-week Bharatanatyam (Indian Classical Dance) intervention on wellbeing indicators in Midwestern high school students. METHODS: Using a single arm design, freshmen at a Midwestern high school completed an ethics-approved 8-week Bharatanatyam program teaching movements rooted in social cognitive theory and cultural foundations. At baseline, four, and 8 weeks, participants completed PROMIS Pediatric Profile-25 (Physical Function Mobility, Anxiety, Depressive Symptoms, Fatigue, Peer Relations, Pain Interference, and Pain Intensity), Body Appreciation Scale, Anti-Bias Behavior Scale (PSABBS), State Mindfulness Scale, and an 8-item acceptability questionnaire. Analyses included descriptive statistics, paired t-tests, Cohen's d effect sizes, Pearson's correlations, and linear regressions. RESULTS: Forty-six students provided assent and parental consent and completed the intervention. Most were female (62%) and Caucasian (80%). Feasibility and retention indicators were high (83-89%). Fifty-nine percent reported independent exercise 2-5 times weekly. Controlling for exercise frequency, significant decreases (P < 0.05) were observed between baseline and 8 weeks in PROMIS Anxiety (d = .80), Depressive Symptoms (d = .51), Fatigue (d = .61), and Pain Intensity (d = .77), with significant increases in Peer Relations (d = .80) and Body Appreciation (d = .97). Positive associations were found between anti-bias attitudes and lower anxiety (r = .485, P < .05), depressive symptoms (r = .510, P < .01), fatigue (r = .395, P < .05), and pain intensity (r = .567, P < .05). Anti-bias attitudes had significant associations with pain intensity, depression, and anxiety, and mindfulness was significantly associated with (P < .05) body appreciation. CONCLUSION: This study provides initial evidence that an 8-week Bharatanatyam program improved emotional health and physical symptoms (ie, fatigue and pain) among adolescents, with mindfulness and anti-bias attitudes associated with overall wellbeing. Further testing with more rigorous study designs is warranted. CI - (c) The Author(s) 2026. FAU - Parthasarathy, Shruti AU - Parthasarathy S AUID- ORCID: 0009-0000-3523-3128 AD - Yale School of Public Health, Yale University, New Haven, CT, USA. AD - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. RINGGOLD: 12244 FAU - Sauer, Christina AU - Sauer C AD - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. RINGGOLD: 12244 FAU - Horowitz, Bruriah AU - Horowitz B AD - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. RINGGOLD: 12244 FAU - Victorson, David AU - Victorson D AUID- ORCID: 0000-0002-3530-8633 AD - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. RINGGOLD: 12244 LA - eng PT - Journal Article DEP - 20260616 PL - United States TA - Glob Adv Integr Med Health JT - Global advances in integrative medicine and health JID - 9918556687906676 PMC - PMC13272864 OTO - NOTNLM OT - adolescent OT - bharatanatyam OT - wellbeing COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/19 06:32 MHDA- 2026/06/19 06:33 PMCR- 2026/06/16 CRDT- 2026/06/19 04:49 PHST- 2025/11/23 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/19 06:33 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 04:49 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1177_27536130261459352 [pii] AID - 10.1177/27536130261459352 [doi] PST - epublish SO - Glob Adv Integr Med Health. 2026 Jun 16;15:27536130261459352. doi: 10.1177/27536130261459352. eCollection 2026 Jan-Dec. PMID- 42316462 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260619 LR - 20260813 IS - 1738-3684 (Print) IS - 1976-3026 (Electronic) IS - 1738-3684 (Linking) VI - 23 IP - 6 DP - 2026 Jun TI - Paraben and Phthalate Exposure in Adolescents With Attention-Deficit/Hyperactivity Disorder: A Case-Control Study. PG - 773-789 LID - 10.30773/pi.2025.0444 [doi] AB - OBJECTIVE: This case-control study compared urinary concentrations of parabens and phthalate metabolites between adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy peers and examined whether product-use behaviors accounted for observed exposure differences. METHODS: Adolescents aged 12-17 years with clinically diagnosed ADHD (n=39) and age- and sex-matched healthy controls (n=41) were recruited. Urinary concentrations of seven parabens and ten phthalate metabolites were quantified using validated high-performance liquid chromatography and gas chromatography-mass spectrometry protocols. ADHD symptoms were assessed using Conners Parent and Adolescent Rating Scales. Group comparisons were conducted using t-tests with effect sizes (Cohen's d). Multivariable logistic regression, factorial analysis of covariance (ANCOVA) models (reporting partial eta(2)), and multiple mediation analyses were performed, adjusting for household income, parental education, and body mass index. RESULTS: Differences in the urinary concentrations of several parabens and phthalate metabolites were observed between adolescents with ADHD and controls. However, detection frequencies varied across analytes, and findings for compounds with low detection frequency should be interpreted with caution. In multivariable logistic regression, an association between dimethyl phthalate and ADHD status was observed (odds ratio=6.13; 95% confidence interval, 1.10-34.34), with improved model discrimination (Deltachi(2)=17.2, p=0.002; area under the receiver operating characteristic curve, 0.856-->0.921); however, this finding should be interpreted with caution given its low detection frequency. In ANCOVA models adjusting for product-use behaviors, group differences remained significant only for dimethyl phthalate (F(1, 71)=7.97, p=0.006, eta(2)=0.099); however, this finding should likewise be interpreted with caution due to its low detection frequency. Mediation analyses indicated that recent personal care product use did not substantially mediate the association between ADHD status and chemical exposure levels. CONCLUSION: Adolescents with ADHD showed differences in internal exposure to selected parabens and phthalate metabolites. These findings should be interpreted with caution, particularly for analytes with low detection frequency. Overall, these findings suggest that exposure differences may reflect behavior-linked vulnerability patterns during adolescence rather than short-term cosmetic use alone. Longitudinal studies are needed to clarify temporal and causal pathways. FAU - Terzioglu, Merve Aktas AU - Terzioglu MA AD - Pamukkale University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Denizli, Turkiye. merveaktasterzioglu@gmail.com. FAU - Patlar, Seyfiye AU - Patlar S AD - Pamukkale University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Denizli, Turkiye. FAU - Onac, Canan AU - Onac C AD - Pamukkale University, Faculty of Science, Department of Chemistry and Advanced Technology Application and Research Center, Denizli, Turkiye. FAU - Cort, Aysegul AU - Cort A AD - Pamukkale University, Faculty of Medicine, Department of Biochemistry, Denizli, Turkiye. FAU - Ata, Melek Tunc AU - Ata MT AD - Pamukkale University, Faculty of Medicine, Department of Physiology, Denizli, Turkiye. LA - eng GR - 2023IAP003/Pamukkale University/ PT - Journal Article DEP - 20260608 PL - Korea (South) TA - Psychiatry Investig JT - Psychiatry investigation JID - 101242994 PMC - PMC13284555 OTO - NOTNLM OT - ADHD OT - Adolescent mental health OT - Paraben exposure OT - Personal care products OT - Phthalate exposure COIS- Conflicts of Interest The authors have no potential conflicts of interest to disclose. EDAT- 2026/06/19 06:33 MHDA- 2026/06/19 06:34 PMCR- 2026/06/01 CRDT- 2026/06/19 00:39 PHST- 2025/12/04 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/06/19 06:34 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:39 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - pi.2025.0444 [pii] AID - pi-2025-0444 [pii] AID - 10.30773/pi.2025.0444 [doi] PST - ppublish SO - Psychiatry Investig. 2026 Jun;23(6):773-789. doi: 10.30773/pi.2025.0444. Epub 2026 Jun 8. PMID- 42316387 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260906 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Metabolic risk profiling in childhood obesity through hormonal dysfunction and genetic variants: findings from a retrospective study. LID - 10.1186/s12902-026-02336-5 [doi] LID - 253 AB - BACKGROUND: Childhood obesity is frequently accompanied by endocrine dysfunction and genetic susceptibility, but their combined contribution to metabolic risk remains insufficiently defined. This retrospective study evaluated hormonal, metabolic, and genetic determinants of metabolic syndrome (MetS) in children and adolescents with obesity. METHODS: Electronic medical records from January 2021 to May 2025 were reviewed. A total of 429 children and adolescents with obesity were included. Clinical, biochemical, endocrine, and targeted SNP genotyping data for FTO rs9939609, MC4R rs17782313, and LEPR rs1137101 were analyzed. MetS was defined according to pediatric criteria. Multivariable logistic regression and receiver operating characteristic analysis were performed. RESULTS: MetS was present in 187 participants (43.6%). Fasting glucose averaged 5.3 +/- 0.5 mmol/L, HbA1c averaged 5.24 +/- 0.22%, and median HOMA-IR was 4.4 (2.7-5.7). Insulin resistance was observed in 68.0% of Tanner stage I participants and 73.3% of Tanner stage II-V participants. Elevated HOMA-IR was strongly associated with MetS (OR = 2.89, 95% CI: 1.71-4.99, P < 0.001). Leptin was positively associated with MetS risk (OR = 1.32, 95% CI: 1.02-1.70, P = 0.033), whereas adiponectin was inversely associated (OR = 0.63, 95% CI: 0.49-0.80, P < 0.001). FTO and MC4R risk allele carriage independently predicted MetS, with ORs of 1.88 and 1.71, respectively. The combined endocrine-genetic model showed acceptable discrimination (AUC = 0.751). CONCLUSION: Insulin resistance, adipokine imbalance, and FTO/MC4R variants were independently associated with MetS in pediatric obesity. Integrated endocrine-genetic profiling may improve early metabolic risk stratification. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Shi, Xueqin AU - Shi X AD - Department of Adolescent Health, Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yancheng, Jiangsu, 224002, China. FAU - Wang, Qianqian AU - Wang Q AD - Department of Adolescent Health, Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yancheng, Jiangsu, 224002, China. FAU - Yin, Wenli AU - Yin W AD - Department of Adolescent Health, Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yancheng, Jiangsu, 224002, China. FAU - Zhou, Chong AU - Zhou C AD - Department of Adolescent Health, Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yancheng, Jiangsu, 224002, China. zyx15189379320@163.com. LA - eng PT - Journal Article DEP - 20260618 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - EC 1.14.11.33 (FTO protein, human) RN - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) RN - 0 (Receptor, Melanocortin, Type 4) RN - 0 (MC4R protein, human) RN - 0 (Receptors, Leptin) RN - 0 (LEPR protein, human) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - *Metabolic Syndrome/genetics/epidemiology/etiology/metabolism MH - Child MH - Male MH - *Pediatric Obesity/genetics/complications/metabolism MH - *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics MH - Adolescent MH - *Polymorphism, Single Nucleotide MH - Insulin Resistance MH - Receptor, Melanocortin, Type 4/genetics MH - Receptors, Leptin/genetics MH - Genetic Predisposition to Disease MH - Follow-Up Studies MH - Risk Factors MH - Prognosis MH - *Biomarkers/analysis PMC - PMC13543467 OTO - NOTNLM OT - Adipokines OT - Childhood obesity OT - FTO OT - Insulin resistance OT - MC4R OT - Metabolic syndrome COIS- Declarations. Ethical approval: This study has been approved by the Ethics Committee of Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University (Approval Number: 2025-LW-016). The Ethics Committee reviewed and approved the retrospective use of anonymized clinical and biochemical data, as well as the targeted genotyping of predefined obesity-related SNPs for the archived remaining blood samples. No additional sample collection was conducted. Since the risk of this study was extremely low, de-identified retrospective data and remaining biological samples were used, and it would not affect the diagnosis, treatment or clinical management of patients. Therefore, the Ethics Committee waived the requirement for individual informed consent. Consent to participate: Ethical approval was obtained from the Institutional Review Board of the hospital, and, as the study was retrospective and all data were anonymized, the requirement for informed consent was waived. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/09/04 05:36 PMCR- 2026/06/18 CRDT- 2026/06/19 00:20 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/09/04 05:36 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:20 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12902-026-02336-5 [pii] AID - 2336 [pii] AID - 10.1186/s12902-026-02336-5 [doi] PST - epublish SO - BMC Endocr Disord. 2026 Jun 18;26(1):253. doi: 10.1186/s12902-026-02336-5. PMID- 42316363 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260619 LR - 20260813 IS - 3059-4057 (Electronic) IS - 3059-4057 (Linking) VI - 12 IP - 1 DP - 2026 Jun 19 TI - Pulmonary adverse events associated with GLP-1 receptor agonists: a systematic review of respiratory safety signals. LID - 10.1186/s40842-026-00311-6 [doi] LID - 43 AB - BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are among the most rapidly growing drug classes in contemporary medicine, approved for type 2 diabetes mellitus (T2DM) and obesity management. Although gastrointestinal adverse effects are well characterised, the pulmonary safety profile of GLP-1 RAs remains incompletely defined, representing an important evidence gap given the scale of global prescribing. OBJECTIVE: This systematic review aims to synthesise published evidence on respiratory adverse events temporally associated with GLP-1 RA therapy in adults, characterise their patterns and severity, appraise the risk of bias using validated design-appropriate tools, describe proposed pathophysiological mechanisms, and grade the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Given the heterogeneity of the included evidence-spanning case reports, pharmacovigilance analyses, and observational cohorts-this review is framed primarily as a signal-detection and evidence-mapping exercise rather than a causal-inference analysis. ELIGIBILITY CRITERIA: Adults (>/= 18 years) receiving any approved GLP-1 RA for any indication. Eligible study designs included randomised controlled trials (RCTs), retrospective and prospective observational cohorts, pharmacovigilance disproportionality analyses, and case reports or series. Studies were excluded if they enrolled paediatric populations, involved animal or in vitro experiments, reported only metabolic or cardiovascular outcomes without respiratory adverse-event data, or were narrative reviews, editorials, or commentaries without primary data. METHODS: A systematic review was conducted following PRISMA 2020 guidelines (PROSPERO: CRD420261305875). PubMed, Embase, and Scopus were searched from inception to January 2026. Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB2) tool for RCTs, the Newcastle-Ottawa Scale (NOS) for cohort studies, and Joanna Briggs Institute (JBI) checklists for case reports, case series, and pharmacovigilance studies. GRADE was applied at the outcome-domain level; evidence from uncontrolled designs (case reports, case series, pharmacovigilance analyses) was initially rated very low certainty, as these designs are inherently uncontrolled and start below the lowest GRADE tier. Given substantial heterogeneity, meta-analytic pooling was not performed; a pre-specified narrative synthesis following the Synthesis Without Meta-Analysis (SWiM) reporting guideline was conducted. RESULTS: Nineteen studies met inclusion criteria: four RCTs (n = 1,884 participants), five retrospective cohort studies (n = 1,122,653 participants), three pharmacovigilance analyses (n = 498,892 spontaneous adverse-event reports), and seven case reports or case series (n = 13 patients). Spontaneous reports do not represent unique exposed individuals and were not pooled with participant counts. Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low); three of five cohort studies were rated moderate and one high risk by NOS (one cohort study rating not reported, classified as not reported/unable to rate); all three pharmacovigilance studies were rated high risk by JBI; and case reports were rated as methodologically adequate by JBI, though these instruments cannot overcome the inherent anecdotal nature and very limited generalisability of single-case designs. Upper respiratory tract infections (URTIs) were the most frequently reported adverse event (8 of 12 reporting studies, 66.7%), occurring at rates comparable to controls across RCTs (GRADE: MODERATE certainty). Pharmacovigilance analyses identified disproportionate reporting signals for dyspnoea and asthma-like events, particularly with exenatide, using the reporting odds ratio (ROR 2.14, 95% CI 1.88-2.43; Cazzola 2024); these signals are hypothesis-generating only and do not establish causality or incidence. Serious adverse events reported in temporal association with GLP-1 RA exposure included anaphylaxis with bronchospasm (n = 4 cases), acute eosinophilic pneumonia (n = 1), perioperative aspiration pneumonitis or pneumonia (multiple perioperative cases across two cohort studies and one case series), acute respiratory distress syndrome (ARDS; n = 2, one fatal requiring extracorporeal membrane oxygenation [ECMO]), and spontaneous pneumomediastinum (n = 1). A large global retrospective cohort study (n = 331,863 matched patients; Henney 2024) demonstrated a potentially meaningful reduction in incident pneumonia with GLP-1 RAs compared with dipeptidyl peptidase-4 (DPP-4) inhibitors (hazard ratio [HR] 0.60, 95% confidence interval [CI] 0.58-0.62; GRADE: LOW certainty); this finding should be interpreted cautiously given the retrospective design, active and non-inert comparator, and likelihood of residual confounding. Evidence certainty for serious respiratory events was very low, driven by sparse case reports and high-risk pharmacovigilance data. CONCLUSION: GLP-1 RA therapy has a respiratory safety profile that is neither uniformly benign nor hazardous, stratified by mechanism, agent subclass, and clinical context. Common upper airway symptoms are mild and comparable to controls. Rare but clinically consequential events-including anaphylaxis, eosinophilic pneumonia, perioperative aspiration, and ARDS-have been reported in temporal association with GLP-1 RA exposure, predominantly in case reports and pharmacovigilance data of very low certainty; these signals are hypothesis-generating and should not be interpreted as confirmed causal risks. Exendin-4-based agents (exenatide and lixisenatide) appear to carry the highest reported risk of hypersensitivity reactions, attributable to their non-human structural origin. Clinicians should maintain heightened awareness for aspiration risk in perioperative settings; individualised, extended pre-procedural fasting intervals calibrated to the specific agent's pharmacokinetic profile should be considered. Prospective, standardised, and adequately powered studies with pre-specified respiratory endpoints are required to move from signal detection to causal inference. CI - (c) 2026. The Author(s). FAU - Ahuja, Aarushi AU - Ahuja A AD - Department of Internal Medicine, Maulana Azad Medical College, New Delhi, Delhi, India. FAU - Prasad, Sai AU - Prasad S AD - Department of Internal Medicine, S. Nijalingappa Medical College, Navanagar, Bagalkote, Karnataka, 587102, India. saiprasad.jadi@gmail.com. FAU - Manoharan, Sahana AU - Manoharan S AD - Department of Internal Medicine, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India. FAU - Sen, Arya AU - Sen A AD - Department of Internal Medicine, Medical College and Hospital Kolkata, Kolkata, West Bengal, India. FAU - Rana, Richa AU - Rana R AD - Department of Internal Medicine, GMERS Medical College Sola, Ahmedabad, Gujarat, India. FAU - Mody, Mansi AU - Mody M AD - Department of Internal Medicine, MP Shah Government Medical College, Jamnagar, Gujarat, India. FAU - Paras, Fnu AU - Paras F AD - Department of Internal Medicine, Government Medical College Patiala, Patiala, Punjab, India. FAU - Archita, Archita AU - Archita A AD - Department of Internal Medicine, Ziauddin University, Karachi, Pakistan. FAU - Shaik, Sana AU - Shaik S AD - Department of Internal Medicine, Tbilisi State Medical University, Tbilisi, Georgia. FAU - Mehta, Kartik AU - Mehta K AD - Department of Internal Medicine, Maulana Azad Medical College, New Delhi, Delhi, India. FAU - Manoj, Rachel AU - Manoj R AD - Department of Internal Medicine, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova. FAU - Mishra, Prakashini AU - Mishra P AD - Department of Internal Medicine, Government Medical College, Chandigarh, India. FAU - Mehta, Subhi AU - Mehta S AD - Department of Internal Medicine, LLRM Medical College, Meerut, Uttar Pradesh, India. FAU - Kapoor, Pulkit AU - Kapoor P AD - Department of Internal Medicine, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India. LA - eng PT - Journal Article PT - Review DEP - 20260619 PL - England TA - Cardiovasc Diabetol Endocrinol Rep JT - Cardiovascular diabetology. Endocrinology reports JID - 9918994893106676 PMC - PMC13281493 OTO - NOTNLM OT - Aspiration pneumonia OT - Exenatide OT - GLP-1 receptor agonists OT - GRADE OT - Liraglutide OT - Pharmacovigilance OT - Pulmonary adverse events OT - Respiratory safety OT - Semaglutide OT - Systematic review COIS- Declarations. Ethics approval and consent to participate: Not applicable. This study is a systematic review of previously published data and does not involve human participants or patient-level identifiable data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/06/19 06:34 PMCR- 2026/06/19 CRDT- 2026/06/19 00:19 PHST- 2026/03/27 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/06/19 06:34 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:19 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1186/s40842-026-00311-6 [pii] AID - 311 [pii] AID - 10.1186/s40842-026-00311-6 [doi] PST - epublish SO - Cardiovasc Diabetol Endocrinol Rep. 2026 Jun 19;12(1):43. doi: 10.1186/s40842-026-00311-6. PMID- 42316345 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Suicidal ideation and suicide attempts among adolescents and youth in the aftermath of the Tigray war, 2024: prevalence and associated factors. LID - 10.1186/s12888-026-08284-7 [doi] LID - 687 AB - BACKGROUND: Suicide is a leading cause of death among adolescents and youth globally and represents an important public health concern in low- and middle-income and conflict-affected settings. Prior evidence from Ethiopia showed substantial levels of suicidal behavior among young populations even before the recent conflict. Exposure to war-related trauma, violence, displacement, and disruption of health and social systems may further increase the risk of suicidality among adolescents and youth. However, there is limited evidence regarding suicidal ideation and suicide attempts among adolescents and youth in post-war Tigray, Ethiopia. Therefore, this study aimed to assess the prevalence and associated factors of suicidal ideation and suicide attempts among adolescents and youth in the aftermath of the Tigray War. METHODS: A school-based cross-sectional study was conducted among 599 adolescents and youth aged 15-24 years in post-war Tigray, Ethiopia, of whom 57.4% were female. Data were collected using validated tools assessing suicidal ideation, suicide attempts, depression, anxiety, post-traumatic stress disorder, and exposure to violence. Bivariate and multivariable logistic regression analyses were performed to identify factors associated with suicidal ideation and suicide attempts. RESULTS: The prevalence of suicidal ideation was 19.9% (95% CI: 16.7%, 23.3%), while the prevalence of suicide attempts was 9.7% (95% CI: 7.4%, 12.3%).Depression, anxiety, and post-traumatic stress disorder were significantly associated with both suicidal ideation and attempts. Sexual abuse and witnessing physical violence increased the odds of suicidal Attempts. However, physical activity was protective against suicidal ideation. CONCLUSION: The findings suggest that suicidal ideation and suicidal attempts represent important mental health concerns among adolescents and youth in post-war Tigray. Depression, anxiety, PTSD symptoms, and trauma-related experiences were significantly associated with suicidality in this study. Given the cross-sectional nature of the study, causal relationships cannot be inferred. Nevertheless, the findings underscore the need for strengthened adolescent mental health services and trauma-informed support programs in conflict-affected settings. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Gebrehiwot, Tesfay Gebreslassie AU - Gebrehiwot TG AD - Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. gslassie2023@gmail.com. FAU - Woldemariam, Guesh Teklu AU - Woldemariam GT AD - Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Tadese, Haileslassie Tesfay AU - Tadese HT AD - Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Gebremedhin, Haftom Tesfay AU - Gebremedhin HT AD - Department of Psychiatry, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Beraki, Mulu Ftwi AU - Beraki MF AD - Department of Midwifery, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Berhe, Abadi Kidanemariam AU - Berhe AK AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. AD - Tigray Health Research Institute, Mekelle, Tigray, Ethiopia. FAU - Gebremariam, Alem AU - Gebremariam A AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. AD - Tigray Health Research Institute, Mekelle, Tigray, Ethiopia. FAU - Gebre, Yemane Gebremariam AU - Gebre YG AD - Department of Pediatrics, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Alemseged, Embay Amare AU - Alemseged EA AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Tesfau, Yemane Berhane AU - Tesfau YB AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. LA - eng PT - Journal Article DEP - 20260618 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Humans MH - *Suicidal Ideation MH - Ethiopia/epidemiology MH - Female MH - Adolescent MH - *Suicide, Attempted/statistics & numerical data/psychology MH - Prevalence MH - Male MH - Cross-Sectional Studies MH - Young Adult MH - Stress Disorders, Post-Traumatic/epidemiology/psychology MH - Exposure to Violence/statistics & numerical data/psychology MH - Risk Factors MH - Depression/epidemiology MH - Anxiety/epidemiology PMC - PMC13539823 OTO - NOTNLM OT - Ethiopia OT - Post-war OT - Suicidal ideation OT - Suicide attempt OT - Tigray OT - Youth COIS- Declarations. Ethical approval and consent to participate: The study was conducted after Ethical approval was secured from the Adigrat University College of Medicine and Health Sciences Health Research Ethics Review Committee (Reference Number: ADU.CMHS/HRERC/0009/2024) and permission letters were secured from the relevant education offices. Written informed consent was obtained from participants, and assent was obtained from those under 18 years of age in accordance with ethical guidelines. All participants were assured that their involvement was voluntary, would not impact their academic standing, and that the confidentiality of their data would be strictly maintained. A trained and qualified facilitator was available on-site for students to consult with any study-related questions. During the data collection process, privacy was ensured through appropriate seating arrangements and supervision procedures to maintain confidentiality and minimize peer influence during questionnaire completion. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:32 MHDA- 2026/09/03 05:37 PMCR- 2026/06/18 CRDT- 2026/06/19 00:18 PHST- 2025/12/17 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/09/03 05:37 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 00:18 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12888-026-08284-7 [pii] AID - 8284 [pii] AID - 10.1186/s12888-026-08284-7 [doi] PST - epublish SO - BMC Psychiatry. 2026 Jun 18;26(1):687. doi: 10.1186/s12888-026-08284-7. PMID- 42316329 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Jun 18 TI - The feasibility of a novel exercise therapy and activity modification intervention for patients with Sever's disease. LID - 10.1186/s40814-026-01850-6 [doi] LID - 125 AB - BACKGROUND: Sever's disease (calcaneal apophysitis) is a common cause of heel pain in physically active youth. Evidence-based treatment options are limited, with no consensus for the standard of care. This study aimed to assess the feasibility of delivering an intervention comprising exercise therapy and pain-guided activity modification for youth patients with Sever's disease and to describe patient symptoms, functional limitations, psychosocial factors, and ultrasound imaging findings to inform future clinical trials. METHODS: This single-cohort study enrolled patients between 7 and 17 years old with Sever's disease. Participants received a comprehensive 12-week intervention combining daily Achilles-tendon loading exercises, activity modification using a pain-monitoring model, and patient education. Training diaries were provided to monitor adherence, daily activities, and pain. Feasibility was assessed via recruitment and retention rates, daily activity modification adherence, rehabilitation adherence, and safety. Secondary outcomes (patient-reported outcome measures, functional test battery, and ultrasound imaging) were collected at baseline and at 4-, 8-, and 12 weeks and were reported descriptively to characterize the biopsychosocial burden of the condition and inform selection of outcomes and hypotheses for future clinical trials. RESULTS: Of the 13 participants enrolled (7F/6 M, (mean +/- SD) age 11.5 +/- 2.5 years, BMI 21.6 +/- 4.6 kg/m(2)), recruitment and retention rate was 65% and 69%, respectively. Activity modification adherence was 91 +/- 28% (range 37-100%), and rehabilitation adherence was 91 +/- 25% (range 25-100%). Three adverse events occurred and each was unrelated to participation. All participants expressed satisfaction with the intervention (75% [10/10] very satisfied). CONCLUSIONS: Our findings support that this exercise therapy and activity modification intervention is feasible, safe, and appropriate for the treatment of Sever's disease. Intervention satisfaction ratings and favorable global rating of change scores reported imply that educating patients to use a pain-monitoring model, allowing for modified physical activity, is not detrimental to patients with Sever's disease. A larger randomized controlled trial is warranted to evaluate the effectiveness of this intervention. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04816188. Registered 18th of March, 2021 retrospectively. CI - (c) 2026. The Author(s). FAU - Hanlon, Shawn L AU - Hanlon SL AUID- ORCID: 0000-0002-5866-9853 AD - Department of Kinesiology, California State University, Fullerton, CA, USA. shanlon@fullerton.edu. AD - Department of Physical Therapy, University of Delaware, Newark, DE, USA. shanlon@fullerton.edu. FAU - Seymore, Kayla D AU - Seymore KD AD - Department of Physical Therapy, University of Delaware, Newark, DE, USA. FAU - Potter, Morgan N AU - Potter MN AD - Department of Physical Therapy, University of Delaware, Newark, DE, USA. FAU - Bley, Bradley C AU - Bley BC AD - Delaware Sports Medicine, Wilmington, DE, USA. FAU - Silbernagel, Karin Gravare AU - Silbernagel KG AD - Department of Physical Therapy, University of Delaware, Newark, DE, USA. LA - eng SI - ClinicalTrials.gov/NCT04816188 GR - 001_2021/Eastern Athletic Trainer's Association/ GR - R01AR07203401/AR/NIAMS NIH HHS/United States GR - T32HD007490/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - 1920DGP08/National Athletic Trainer's Association Research and Education Foundation/ GR - R01 AR072034/AR/NIAMS NIH HHS/United States GR - T32 HD007490/HD/NICHD NIH HHS/United States GR - R01AR07203401/AR/NIAMS NIH HHS/United States PT - Journal Article DEP - 20260618 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13520403 OTO - NOTNLM OT - Apophysitis OT - Overuse injury OT - Pediatric OT - Treatment OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: This study was approved by the University of Delaware Institutional Review Board (ID: 1652996-3) and is registered with ClinicalTrials.gov (ID: NCT04816188). Written parental permission and child assent were required for all participants before enrollment. Consent for publication: Not applicable. Competing interests: All authors declare that they have no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/06/19 06:34 PMCR- 2026/06/18 CRDT- 2026/06/19 00:17 PHST- 2024/11/15 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/06/19 06:34 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:17 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s40814-026-01850-6 [pii] AID - 1850 [pii] AID - 10.1186/s40814-026-01850-6 [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Jun 18;12(1):125. doi: 10.1186/s40814-026-01850-6. PMID- 42316104 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260830 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Consumption of ultra-processed foods and associated factors in Spanish children aged 8-12 years: a cross-sectional analysis within the INMA cohort study. LID - 10.1186/s12889-026-28008-6 [doi] LID - 2471 AB - BACKGROUND: The consumption of ultra-processed foods (UPF) has been associated with adverse health effects. The predictors of consumption, particularly in high-intake groups like children and adolescents, are scarcely understood. METHODS: We evaluated UPF consumption and associated factors among male and female Spanish children aged 8-12 years participating in the INMA birth cohort. We cross-sectionally analyzed data from 1565 mother-child pairs at age 8 and 314 pairs at age 12. Children's diets were assessed using validated food frequency questionnaires. UPF consumption was defined using the NOVA classification and categorized into tertiles. The associations between maternal-child characteristics and children's UPF consumption were analyzed using multinomial logistic regression to estimate relative risk ratios (RRR) and 95% confidence intervals (95%CI). RESULTS: At age 8, high UPF consumption was associated with low maternal social class, RRR = 2.22 (1.46-3.37), moderate maternal UPF consumption during pregnancy, RRR = 1.87 (1.35-2.58), high maternal UPF consumption during pregnancy, RRR = 3.47 (2.40-4.99), being male, RRR = 1.76 (1.34-2.30), and high children's TV viewing, RRR = 1.76 (1.19-2.60). At age 12, high UPF consumption was associated with high maternal UPF consumption during pregnancy, RRR = 3.09 (1.27-7.50), and high children's TV viewing, RRR = 2.34 (1.05-5.21), although it was inversely associated with maternal university education, RRR = 0.21 (0.06-0.69), and high children's physical activity, RRR = 0.43 (0.20-0.93). CONCLUSIONS: Maternal factors such as high UPF consumption during pregnancy, low social class and low education level, and low physical activity and TV watching during childhood and adolescence, were predictors of higher UPF consumption at the age of 8 and 12 years. CI - (c) 2026. The Author(s). FAU - Compan-Gabucio, Laura-Maria AU - Compan-Gabucio LM AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Department of Surgery and Pathology, Miguel Hernandez University, Sant Joan d'Alacant, Valencian Community, Alicante, 03550, Spain. FAU - Oncina-Canovas, Alejandro AU - Oncina-Canovas A AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Torres-Collado, Laura AU - Torres-Collado L AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Fernandez-Tardon, Guillermo AU - Fernandez-Tardon G AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Health Research Institute of the Principality of Asturias (ISPA), Asturias, Asturias, Principality of Asturias, Oviedo, 33011, Spain. AD - Faculty of Medicine, Community of Madrid, Universidad Nebrija, Hoyo de Manzanares, Community of Madrid, Madrid, 28015, Spain. FAU - Tardon, Adonina AU - Tardon A AD - Health Research Institute of the Principality of Asturias (ISPA), Asturias, Asturias, Principality of Asturias, Oviedo, 33011, Spain. AD - Faculty of Medicine, Community of Madrid, Universidad Nebrija, Hoyo de Manzanares, Community of Madrid, Madrid, 28015, Spain. FAU - Santa-Marina Rodriguez, Loreto AU - Santa-Marina Rodriguez L AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Barroeta, Ziortza AU - Barroeta Z AD - Department of Preventive Medicine and Public Health, University of the Basque Country UPV/EHU, Basque Country, Leioa, Biscay, Basque Country, 48940, Spain. FAU - Vrijheid, Martine AU - Vrijheid M AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - ISGlobal, Barcelona, Catalonia, 08036, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, 08005, Spain. FAU - Warkentin, Sarah AU - Warkentin S AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - ISGlobal, Barcelona, Catalonia, 08036, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, 08005, Spain. FAU - Llop, Sabrina AU - Llop S AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Epidemiology and Environmental Health Joint Research Unit, FISABIO, Valencian Community, Valencian Community, Valencia, 46020, Spain. FAU - Soler-Blasco, Raquel AU - Soler-Blasco R AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Epidemiology and Environmental Health Joint Research Unit, FISABIO, Valencian Community, Valencian Community, Valencia, 46020, Spain. FAU - Ojeda-Belokon, Carolina AU - Ojeda-Belokon C AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Garcia-de-la-Hera, Manuela AU - Garcia-de-la-Hera M AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Vioque, Jesus AU - Vioque J AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. vioque@umh.es. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. vioque@umh.es. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. vioque@umh.es. AD - Department of Preventive Medicine and Public Health, University of the Basque Country UPV/EHU, Basque Country, Leioa, Biscay, Basque Country, 48940, Spain. vioque@umh.es. AD - H feminine de la Ciencia y Ginecologia, Facultad de Medicina, Avda. Ramon y Cajal s/n. 03550-Sant Joan d'Alacant, Valencian Community, Alicante, Spain. vioque@umh.es. FAU - Gonzalez-Palacios, Sandra AU - Gonzalez-Palacios S AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. LA - eng GR - CEX2023-0001290-S/MCIN/AEI/ 10.13039/501100011033, and support from the Generalitat de Catalunya/ GR - 2021 BP 00058/Agency for Management of University and Research Grants with a Beatriu de Pinos post-doctoral fellowship/ GR - CIGE2023/142/Generalitat Valenciana/ GR - PROMETEO-CIPROM/2024/66/Generalitat Valenciana/ GR - grant code PN22_CGE45/General Council of Official Nursing Boards of Spain and the Spanish Institute of Nursing Research/ GR - 04-541-6-2024-0153-N/"Personal Investigador en Formacion" from the "Universidad Miguel Hernandez de Elche"/ GR - PI11/01007/Instituto de Salud Carlos III/ GR - Project PI23/01568/Instituto de Salud Carlos III/ GR - ESP24PI02/2024/Consorcio Centro de Investigacion Biomedica en Red/ PT - Journal Article DEP - 20260618 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Child MH - Female MH - Spain MH - Male MH - Cross-Sectional Studies MH - *Fast Foods/statistics & numerical data MH - *Diet/statistics & numerical data MH - Cohort Studies MH - Birth Cohort PMC - PMC13523201 OTO - NOTNLM OT - Adolescents OT - Birth cohort study OT - Children OT - Determinants OT - Sex-specific OT - Ultra-Processed Foods COIS- Declarations. Ethics approval and consent to participate: All pregnant women provided written informed consent prior to their inclusion in the study. In the case of their offspring, written informed consent was obtained from their parents or legal guardians. The study was conducted in accordance with the principles of the Declaration of Helsinki and its later amendments. The study protocol was approved by the following Ethics Committees: the Clinical Research Ethics Committee of Hospital Universitario La Fe (Valencia, Spain); the Clinical Research Ethics Committee of Area Sanitaria de Gipuzkoa (Gipuzkoa, Spain); the Clinical Research Ethics Committee of Parc de Salut del Mar (Barcelona, Spain); and the Clinical Research Ethics Committee of the Principado de Asturias (Spain). The present work was additionally approved by the Clinical Research Ethics Committee of the Alicante Health Department - Hospital General (Ref.: PI2024-087, June 19, 2024). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/08/28 11:46 PMCR- 2026/06/18 CRDT- 2026/06/19 00:07 PHST- 2026/03/20 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:07 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12889-026-28008-6 [pii] AID - 28008 [pii] AID - 10.1186/s12889-026-28008-6 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 18;26(1):2471. doi: 10.1186/s12889-026-28008-6. PMID- 42316044 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Machine learning to improve the prediction of Large for Gestational Age (LGA) neonates: a cohort study. LID - 10.1186/s12884-026-09411-8 [doi] LID - 956 AB - BACKGROUND: Prediction of Large for Gestational Age (LGA) risk is important as it can enable earlier, more effective interventions, and avoid or mitigate cumulative injury to both mother and baby at the time of delivery. The goal of this research is to improve the prediction of LGA using machine learning (ML) models and variables that are widely available as that allow for broad intervention in late pregnancy and during delivery. METHODS: An improved prediction of LGA was achieved using twelve ML models with hyperparameter optimization. Also, to improve the LGA prediction a data augmentation method was employed in the training set. Additionally, improvement in LGA prediction was obtained with four variable selection methods employed to identify the most significant variables. To rank the best models on the validation set after training, the Area under the Receiver Operating Characteristic Curve (AUROC) was used. Finally, to assess the generalization performance, the best models were evaluated on the test set. RESULTS: Our method enabled us to identify several models with high sensitivity and specificity. The best models included those that achieved a sensitivity of 0.84, a specificity of 0.84, an accuracy of 0.84, and AUCROC 0.83, requiring 14 variables. Another model reached an accuracy of 0.87, a sensitivity of 0.71, and a specificity of 0.90 with an AUCROC of 0.83 (14 variables). Additionally, a model with a sensitivity of 0.58, the same as that described by Hadlock et al. [1] for ultrasound, required 10 variables, and reached an accuracy of 0.91, a specificity of 0.97, and an AUCROC of 0.86. Both models included maternal BMI (body mass index), First Control, Maternal Weight, BMI Last Control, and EFW (estimated fetal weight) as the most important variables. CONCLUSIONS: The main contributions of our study include the prediction of LGA using data obtained from standard clinical evaluations during prenatal care, as well as the development ML models, tuning the hyperparameters to improve prediction results, thus achieving high levels of sensitivity and specificity. To achieve optimal LGA prediction outcomes across different models, a data augmentation approach is introduced, an important improvement in LGA prediction over using only Hadlock's ultrasound formula. CI - (c) 2026. The Author(s). FAU - Cubillos, Gabriel AU - Cubillos G AD - Department of Electrical Engineering, Universidad de Chile, Av. Tupper 2007, Santiago, 8370451, Chile. AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. FAU - Monckeberg, Max AU - Monckeberg M AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. FAU - Plaza, Alejandra AU - Plaza A AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. FAU - Morgan, Maria AU - Morgan M AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. FAU - Estevez, Pablo A AU - Estevez PA AD - Department of Electrical Engineering, Universidad de Chile, Av. Tupper 2007, Santiago, 8370451, Chile. AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. FAU - Choolani, Mahesh AU - Choolani M AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. FAU - Kemp, Matthew W AU - Kemp MW AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. FAU - Li, Sarah W L AU - Li SWL AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. FAU - Illanes, Sebastian E AU - Illanes SE AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. sillanes@uandes.cl. AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. sillanes@uandes.cl. AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. sillanes@uandes.cl. FAU - Perez, Claudio A AU - Perez CA AD - Department of Electrical Engineering, Universidad de Chile, Av. Tupper 2007, Santiago, 8370451, Chile. clperez@ing.uchile.cl. AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. clperez@ing.uchile.cl. LA - eng GR - IMPACT, #FB210024/Agencia Nacional de Investigacion y Desarrollo (ANID)/ PT - Journal Article DEP - 20260618 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Infant, Large for Gestational Age MH - Predictive Learning Models MH - Infant, Newborn MH - *Machine Learning MH - Prediction Algorithms MH - ROC Curve MH - Sensitivity and Specificity MH - Gestational Age MH - Cohort Studies MH - Area Under Curve MH - Adult MH - Classification Algorithms MH - Ultrasonography, Prenatal MH - *Fetal Macrosomia/diagnosis PMC - PMC13520273 OTO - NOTNLM OT - Commonly accessible variables OT - Data augmentation techniques OT - LGA prediction OT - Large for Gestational Age (LGA) OT - Machine learning algorithms OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: The data usage was approved by the by the institutional review board (IRB) of Hospital Parroquial de San Bernardo, Santiago, Chile, who determined that the research does not involve human subjects because the study uses previously collected, de-identified data. The "Comite de Etica del Hospital Parroquial de San Bernardo" waived the need for informed consent. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:32 MHDA- 2026/08/27 05:35 PMCR- 2026/06/18 CRDT- 2026/06/19 00:05 PHST- 2024/09/17 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 00:05 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12884-026-09411-8 [pii] AID - 9411 [pii] AID - 10.1186/s12884-026-09411-8 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 18;26(1):956. doi: 10.1186/s12884-026-09411-8. PMID- 42315960 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261008 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 80 IP - 9 DP - 2026 Sep TI - Comparative machine learning modeling of resting energy expenditure estimation in mechanically ventilated children after cardiac surgery. PG - 949-957 LID - 10.1038/s41430-026-01775-6 [doi] AB - OBJECTIVE: Nutrition status is vital for children's recovery following cardiac surgery, with substantial inter-individual variability in metabolic demands. We aimed to develop machine learning (ML) models of postoperative resting energy expenditure (REE) by analysing the influential factors. METHODS: We retrospectively analyzed children who underwent indirect calorimetry (IC) for valid REE measurements within 4 to 24 h after cardiac surgery between January 2021 and December 2022 at our center. Nine ML algorithms were trained to predict REE. Bland-Altman analysis assessed agreement with measured REE, and SHAP was used for population-level interpretation and a representative patient case. RESULTS: A total of 278 mechanically ventilated children were analyzed. REE measured by IC ranged from 387 to 2642 kcal/d (715 [550, 964]). The root mean square error (RMSE) of the ML models ranged from 226 (95% CI: 184-267) to 281 (95% CI: 225-344) kcal/d, while the range for conventional equations was 249 (95% CI: 215-287) to 282 (95% CI: 252-315) kcal/d. Regularized linear models achieved the highest R(2) of 0.64 (95% CI: 0.49-0.76). The top 10 most important variables associated with REE in the optimal model are weight, age, height, preoperative serum albumin, preoperative CK-MB, vasoactive inotropic score (VIS), CPB time, postoperative LVEDD Z-score, gender, and postoperative NT-proBNP. CONCLUSIONS: This study developed ML models to predict REE in children after cardiac surgery, with some models outperforming conventional equations. These findings highlight the potential of machine learning to optimize postoperative nutritional management by accurately capturing the non-linear metabolic response to surgical stress. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Li, Chenyu AU - Li C AUID- ORCID: 0009-0002-0211-0441 AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zhu, Zhiyuan AU - Zhu Z AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Wang, Shilin AU - Wang S AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Li, Chao AU - Li C AD - Capital Center for Children's Health, Capital Institute of Pediatrics, Capital Medical University, Beijing, China. FAU - Lu, Zhongyuan AU - Lu Z AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Chen, Qinnan AU - Chen Q AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Wang, Xu AU - Wang X AUID- ORCID: 0000-0002-4887-3367 AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. fwpicu@163.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260618 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Female MH - *Machine Learning MH - *Respiration, Artificial MH - Male MH - *Cardiac Surgical Procedures MH - Retrospective Studies MH - Calorimetry, Indirect MH - Child, Preschool MH - Infant MH - *Basal Metabolism/physiology MH - Postoperative Period MH - Child MH - Nutritional Status MH - Predictive Learning Models MH - *Energy Metabolism COIS- Competing interests: The authors declare no competing interests. Ethical approval: This study was approved by the Ethics Committee of the Fuwai Hospital in 2022 (ID: 2022-1859). This study complied with the ethical principles laid out in the Helsinki Declaration of 1975, as revised in 2008. Informed consent: In this study, the ethics committee approved the waiver of informed consent. EDAT- 2026/06/19 00:36 MHDA- 2026/09/10 05:37 CRDT- 2026/06/18 23:34 PHST- 2025/08/12 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/05/01 00:00 [revised] PHST- 2026/09/10 05:37 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 23:34 [entrez] AID - 10.1038/s41430-026-01775-6 [pii] AID - 10.1038/s41430-026-01775-6 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Sep;80(9):949-957. doi: 10.1038/s41430-026-01775-6. Epub 2026 Jun 18. PMID- 42315803 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260922 IS - 2730-7174 (Electronic) IS - 2730-7166 (Print) IS - 2730-7166 (Linking) VI - 54 IP - 4 DP - 2026 Jun 18 TI - Feasibility and Acceptability of a Smartphone and Wearable Assessment Protocol for Adolescents with Depression. LID - 10.1007/s10802-026-01464-9 [doi] LID - 78 AB - Smartphones and wearables are low-burden tools for assessing real-time mood and behavior. Although these methods have been used with adolescents for behavioral tracking (e.g., activity, sleep), less is known about longer-term use (beyond one week) with adolescents with depression and about mobile sensing for monitoring mood for any adolescent population. This study examined acceptability and feasibility of a one-month EMA, actigraphy, and mobile sensing protocol for adolescents with elevated depressive symptoms. Adolescents aged 12 to 18 (N = 69; Mage = 15.46; 67% assigned female at birth; 42% White; 71% Hispanic or Latine; 38% sexual minority) completed EMA surveys on depressive symptoms, processes, and affect multiple times daily via a smartphone app that also collected passive sensor data (e.g., motion, geolocation). An actigraph measured physical activity and sleep. A feedback interview assessed protocol acceptability. Most participants (91%) completed all components, were willing to participate again (91%), and would recommend participation to peers (93%). EMA response rates improved (mean completion 57% to 66%) after shifting to a semi-personalized schedule with extended response windows. Actigraph wear time was high (> 70%) despite device-related issues. Sensor data availability varied by operating system, and privacy concerns influenced participation. Adherence was correlated within and between modalities, suggesting that individual compliance played a central role in consistent engagement. Findings support the feasibility and acceptability of smartphone and wearable methods for capturing real-world mood and behavior in adolescents, however careful attention to design, engagement, and ethical considerations remains essential. CI - (c) 2026. The Author(s). FAU - Guo, Jenny AU - Guo J AUID- ORCID: 0000-0002-3535-5181 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. jguo033@fiu.edu. FAU - Frederick, Jennifer AU - Frederick J AUID- ORCID: 0000-0001-9411-4284 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. FAU - Cunningham, Lindsey AU - Cunningham L AUID- ORCID: 0000-0003-4700-5231 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. FAU - Jacobson, Nicholas C AU - Jacobson NC AUID- ORCID: 0000-0002-8832-4741 AD - Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA. AD - Quantitative Biomedical Sciences Program, Dartmouth College, Hanover, NH, USA. AD - Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA. AD - Department of Psychiatry, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA. FAU - Fisher, Aaron J AU - Fisher AJ AUID- ORCID: 0000-0001-9754-4618 AD - Department of Psychology, University of California, Berkeley, Berkeley, CA, USA. FAU - Pettit, Jeremy W AU - Pettit JW AUID- ORCID: 0000-0002-7426-9411 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. FAU - McMakin, Dana L AU - McMakin DL AUID- ORCID: 0000-0002-6954-4204 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. FAU - Ng, Mei Yi AU - Ng MY AUID- ORCID: 0000-0002-1399-0133 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. LA - eng GR - R21 MH126394/MH/NIMH NIH HHS/United States GR - R21MH126394/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. DEP - 20260618 PL - United States TA - Res Child Adolesc Psychopathol JT - Research on child and adolescent psychopathology JID - 101773609 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Smartphone MH - Feasibility Studies MH - *Actigraphy/instrumentation MH - Child MH - *Wearable Electronic Devices MH - *Depression/diagnosis MH - Male MH - *Mobile Applications MH - *Ecological Momentary Assessment MH - Sleep MH - Digital Health MH - *Patient Acceptance of Health Care PMC - PMC13279485 OTO - NOTNLM OT - Actigraphy OT - Depressive disorder OT - Ecological momentary assessment OT - Feasibility study OT - Mobile sensing OT - Smartphone COIS- Declarations. Ethical Approval: The study was approved by the Institutional Review Board of Florida International University in April 2020 (IRB-20-0257) and renewed annually thereafter. The study was conducted in accordance with the ethical standards of the American Psychological Association. Informed consent was obtained from all individual participants included in the study. Conflict of Interest: The authors declare that they have no conflicts of interest to disclose. EDAT- 2026/06/19 00:36 MHDA- 2026/06/19 00:37 PMCR- 2026/06/18 CRDT- 2026/06/18 23:26 PHST- 2025/11/24 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/06/19 00:37 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 23:26 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1007/s10802-026-01464-9 [pii] AID - 1464 [pii] AID - 10.1007/s10802-026-01464-9 [doi] PST - epublish SO - Res Child Adolesc Psychopathol. 2026 Jun 18;54(4):78. doi: 10.1007/s10802-026-01464-9. PMID- 42315727 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261011 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 9 DP - 2026 Sep TI - Toward an intergenerational model of metabolic and bariatric surgery: reframing the household as the unit of care. PG - 1893-1898 LID - 10.1038/s41366-026-02131-1 [doi] AB - Obesity is a chronic, relapsing disease that increasingly spans generations within households, yet contemporary metabolic and bariatric surgery (MBS) models remain oriented toward individuals or single-generation patients. A growing body of evidence demonstrates that obesity risk, behaviors, and treatment responses cluster within family systems, and that MBS produces measurable metabolic and behavioral effects among untreated spouses, partners, and children. Concurrently, decades of pediatric research confirm that caregiver engagement and integration is one of the strongest determinants of successful obesity treatment. Together, these observations support a paradigm shift toward an intergenerational, family-centered model of MBS, in which the household becomes the unit of care. This perspective synthesizes evidence supporting the biological, behavioral, and environmental interdependence of obesity within families and outlines a comprehensive framework for implementing household-level bariatric care. Core components include integrated pediatric-adult clinical infrastructure; combined multidisciplinary teams trained across the age spectrum; harmonized protocols for evaluation, education, and follow-up; coordinated scheduling and workflow alignment; and family-based behavioral strategies that promote shared goals, consistent routines, and mutual accountability. Operational and policy innovations, such as cross-departmental agreements, unified electronic health records, and coordinated billing can facilitate sustainable implementation. We further identify research priorities, including quantifying metabolic ripple effects among untreated family members, evaluating bundled household-level interventions, and developing validated metrics to assess changes in the home environment. Treating the household as the patient offers a promising strategy to enhance medical obesity treatment, surgical durability, improve adherence, and disrupt intergenerational transmission of obesity. As obesity increasingly presents as a family condition, an intergenerational MBS model may help realign treatment with the realities of lived experience and improve outcomes across generations. CI - (c) 2026. The Author(s). FAU - Vidmar, Alaina P AU - Vidmar AP AUID- ORCID: 0000-0003-3790-6255 AD - Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of USC, Los Angeles, CA, USA. avidmar@chla.usc.edu. FAU - Samakar, Kamran AU - Samakar K AUID- ORCID: 0000-0002-1710-6245 AD - Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles and Keck School of Medicine of USC,, Los Angeles, CA, USA. AD - Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, USA. FAU - Martin, Matthew J AU - Martin MJ AD - Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles and Keck School of Medicine of USC,, Los Angeles, CA, USA. AD - Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, USA. FAU - Morton, John Magana AU - Morton JM AD - Department of Surgery, Yale School of Medicine, New Haven, CT, USA. LA - eng PT - Journal Article PT - Review DEP - 20260618 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - *Bariatric Surgery MH - Child MH - *Intergenerational Relations MH - *Obesity/surgery MH - Female PMC - PMC13649551 COIS- Competing interests: The authors have no pertinent financial interests/personal relationships relevant to the submitted manuscript. Financial interests/personal relationships not relevant to the submitted manuscript include: APV: Soleno Pharmaceuticals: consulting; Lilly and Company: funding research grant; Rhythm Pharmaceuticals: funding research grant. All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/19 00:36 MHDA- 2026/10/09 05:30 PMCR- 2026/06/18 CRDT- 2026/06/18 23:23 PHST- 2026/02/17 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/05/05 00:00 [revised] PHST- 2026/10/09 05:30 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 23:23 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1038/s41366-026-02131-1 [pii] AID - 2131 [pii] AID - 10.1038/s41366-026-02131-1 [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Sep;50(9):1893-1898. doi: 10.1038/s41366-026-02131-1. Epub 2026 Jun 18. PMID- 42315306 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260902 IS - 1535-5667 (Electronic) IS - 0161-5505 (Linking) VI - 67 IP - 9 DP - 2026 Sep 2 TI - Pediatric Reference Ranges for Glomerular Filtration Rate Determined by a Single Injection of (99m)Tc-DTPA. PG - 1469-1473 LID - 10.2967/jnumed.125.271392 [doi] AB - Determination of glomerular filtration rate (GFR) with (99m)Tc-labeled diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) is a validated method to assess renal function, but there are no well-established pediatric reference ranges for GFR. The aim of this study was to establish reference GFRs in children and young adults. Methods: GFR was calculated for 235 reference subjects (median age, 4.86 y; range, 20 d to 24.8 y) using (99m)Tc-DTPA at Boston Children's Hospital between 2000 and 2020. This included 220 patients for prechemotherapy evaluation and 15 potential kidney donors. GFR was determined using a single-compartment model after a single intravenous injection technique and serial blood sampling at 2, 3, and 4 h. Data were analyzed by age, corrected for body surface area, and normalized to a body surface area of 1.73 m(2) The 95% reference ranges were calculated as mean +/- 1.96 SD. Results: GFR increased with age, likely reflecting increased functional renal mass. Lower normalized GFR in children younger than 1 y may reflect renal immaturity. Conclusion: The use of a single injection of (99m)Tc-DTPA revealed that GFR increases with age, likely reflecting increased renal mass. Further, in patients younger than 1 y, GFR rapidly increases initially, with a subsequent more gradual increase, reaching the adult level by approximately 2 y of age. Between 2 and 10 y of age, the GFR slightly exceeds the adult level, stabilizing at a slightly lower adult level by 10 y of age. CI - (c) 2026 by the Society of Nuclear Medicine and Molecular Imaging. FAU - Zukotynski, Katherine A AU - Zukotynski KA AD - Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada; katherine.zukotynski@utoronto.ca. AD - Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. AD - Department of Diagnostic and Interventional Radiology, Roswell Park Comprehensive Cancer Center, Buffalo, New York. FAU - Grant, Frederick D AU - Grant FD AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Du, Leanne AU - Du L AD - Department of Medical Imaging, Gold Coast University Hospital, Southport, Queensland, Australia. FAU - Hsiao, Edward AU - Hsiao E AD - Melanoma Institute Australia, University of Sydney, Sydney, New South Wales, Australia. AD - Royal North Shore Hospital, Sydney, New South Wales, Australia. FAU - Zurakowski, David AU - Zurakowski D AD - Boston Children's Hospital, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts; and. FAU - Valencia, Valentina Ferrer AU - Valencia VF AD - Boston Children's Hospital, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts; and. FAU - Treves, S Ted AU - Treves ST AD - Harvard Medical School, Boston, Massachusetts; and. AD - Brigham and Women's Hospital, Boston, Massachusetts. FAU - Fahey, Frederic H AU - Fahey FH AD - Boston Children's Hospital, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts; and. LA - eng PT - Journal Article DEP - 20260902 PL - United States TA - J Nucl Med JT - Journal of nuclear medicine : official publication, Society of Nuclear Medicine JID - 0217410 RN - VW78417PU1 (Technetium Tc 99m Pentetate) RN - 0 (Radiopharmaceuticals) SB - IM MH - Humans MH - *Technetium Tc 99m Pentetate/administration & dosage MH - *Glomerular Filtration Rate MH - Reference Values MH - Child, Preschool MH - Child MH - Female MH - Male MH - Infant MH - Adolescent MH - Young Adult MH - Kidney Function Tests/standards MH - Infant, Newborn MH - Radiopharmaceuticals/administration & dosage OTO - NOTNLM OT - 99mTc-DTPA OT - glomerular filtration rate OT - pediatric reference ranges OT - renal function OT - single-injection technique EDAT- 2026/06/19 00:36 MHDA- 2026/09/03 01:19 CRDT- 2026/06/18 21:33 PHST- 2026/01/05 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/09/03 01:19 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 21:33 [entrez] AID - jnumed.125.271392 [pii] AID - 10.2967/jnumed.125.271392 [doi] PST - epublish SO - J Nucl Med. 2026 Sep 2;67(9):1469-1473. doi: 10.2967/jnumed.125.271392. PMID- 42315145 OWN - NLM STAT- Publisher LR - 20260618 IS - 1741-2889 (Electronic) IS - 1367-4935 (Linking) DP - 2026 Jun 18 TI - Validation of a parent-report version of the Emotional Eating Scale Adapted for Children and Adolescents Short-Form in American mothers. PG - 13674935261459838 LID - 10.1177/13674935261459838 [doi] AB - Emotional eating is associated with negative outcomes in children, including elevated weight status and disordered eating. The current study assessed the preliminary psychometric properties of a 10-item parent-report version of the Emotional Eating Scale Adapted for Children (EES-C) Short-Form. Participants were 324 mothers of children ages 5-12 years. The parent-report version of the EES-C Short-Form and the Child Feeding Questionnaire were administered to mothers in the United States online. Cronbach's alpha for the parent-report version of the EES-C-Short-Form was in the excellent range (alpha = .94). Mothers reported significantly higher levels of emotional eating in overweight/obese children than healthy weight children eating (effect size = 0.45, p < .001). Maternal reports of their child's emotional eating on the EES-C-Short-Form were associated with maternal concern about their child's weight (r = .285; 95% confidence interval = .18-.39), restricted eating (r = .238; 95% confidence interval = .13-.35), and monitoring of their child's food intake (r = .136; 95% confidence interval = .02-.25) on the Child Feeding Questionnaire, supporting convergent validity. A unidimensional model produced a good fit (chi(2) (35) = 70.31, p = 0.00, CFI = .999, SRMR = .036). Taken as a whole, this study provides preliminary support for the reliability and validity of the parent version of the EES-C Short-Form. FAU - Summers, Emma AU - Summers E AUID- ORCID: 0009-0003-2562-5189 AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA. RINGGOLD: 14643 FAU - Limbers, Christine A AU - Limbers CA AUID- ORCID: 0000-0002-4880-1865 AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA. RINGGOLD: 14643 LA - eng PT - Journal Article DEP - 20260618 PL - England TA - J Child Health Care JT - Journal of child health care : for professionals working with children in the hospital and community JID - 9806360 SB - IM OTO - NOTNLM OT - child OT - emotional eating OT - parents OT - psychometrics EDAT- 2026/06/19 00:36 MHDA- 2026/06/19 00:36 CRDT- 2026/06/18 19:53 PHST- 2026/06/19 00:36 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 19:53 [entrez] AID - 10.1177/13674935261459838 [doi] PST - aheadofprint SO - J Child Health Care. 2026 Jun 18:13674935261459838. doi: 10.1177/13674935261459838. PMID- 42314901 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260918 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 10 DP - 2026 Oct TI - Construct and Criterion Validity of the Comprehensive Food Skills Questionnaire. PG - 156396 LID - S2212-2672(26)00111-5 [pii] LID - 10.1016/j.jand.2026.156396 [doi] AB - BACKGROUND: Increased implementation of teaching kitchens requires a tool with adequate psychometric properties for assessing food skills. One such tool is the 39-item Food Skills Questionnaire, with established face and content validity, and interitem and test-retest reliability. Recently, 8 items were added to create the Comprehensive Food Skills Questionnaire (CFSQ), requiring further validation. OBJECTIVE: The objective of this study was to assess the construct and criterion validity of the CFSQ. DESIGN: This study used a pre-post study design. PARTICIPANTS/SETTING: Year 1 (n = 234; September 2023 and January 2024) and 2 (n = 88; September 2022) students in foods and nutrition courses at a Canadian university completed the CFSQ precourse, with n = 177 (December 2023 and April 2024) and n = 80 postcourse responses (April 2023), respectively. MAIN OUTCOME MEASURES: The primary outcome was total food skills, assessed in 3 domains: Food Selection and Planning, Food Preparation, and Food Safety and Storage. STATISTICAL ANALYSIS: t Tests and analyses of variance were used to test known-group construct validity, and criterion validity was assessed using a 1-sample t test, Bland-Altman plot, and linear regression. RESULTS: Total food skills (mean +/- SD) were significantly higher in known groups: women vs men (Year 1, 70.1 +/- 11.5 vs 63.0 +/- 14.7, respectively; P = .02); those with vs without a previous foods/nutrition/cooking course (Year 1, 70.2 +/- 11.3 vs 66.3 +/- 14.0, respectively; P = .048); primary vs nonprimary cooks (Year 1, 74.1 +/- 12.2 vs 66.5 +/- 11.5; P < .001; Year 2, 80.8 +/- 9.4 vs 69.4 +/- 14.1, respectively; P < .001), greater vs less teen meal preparation (Year 1, 74.4 +/- 11.5 vs 64.1 +/- 12.5, respectively; P < .001; Year 2, 80.2 +/- 9.3 vs 67.9 +/- 17.2, respectively; P < .01), and post- vs precourse (Year 1, 71.8 +/- 11.5 vs 68.9 +/- 12.1; P < .001 and Year 2, 82.1 +/- 9.8 vs 76.0 +/- 12.8; P < .001, respectively). A hypothesized group, greater vs less teen grocery shopping, was also significantly higher (Year 1, 73.8 +/- 10.4 vs 64.3 +/- 12.2; P < .001 and Year 2, 78.7 +/- 10.0 vs 65.5 +/- 17.4 ; P < .01, respectively). A 1-sample t test comparing the mean difference of total food skills and course evaluations (-0.89 +/- 13.4) to 0 was not significant (P = .58). Bland-Altman plot and linear regression (unstandardized beta coefficient = -.084; P = .71) indicated no proportional bias. CONCLUSIONS: The CFSQ demonstrates good construct and criterion validity and is appropriate for assessing food skills in research or practice-based teaching kitchens. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Ulloa, Tahlia AU - Ulloa T AD - Community Health Centres of Northumberland, Port Hope, Ontario, Canada. FAU - Wang, Jinghan AU - Wang J AD - Brescia School of Food and Nutritional Sciences, Faculty of Health Sciences, Western University, London, Ontario, Canada. FAU - Yang, Ying Tong AU - Yang YT AD - Seasons Care Inc, Tecumseh, Ontario, Canada. FAU - Dworatzek, Paula D N AU - Dworatzek PDN AD - Brescia School of Food and Nutritional Sciences, Faculty of Health Sciences, Western University, London, Ontario, Canada. Electronic address: pdworatz@uwo.ca. LA - eng PT - Journal Article PT - Validation Study DEP - 20260618 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - Female MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Male MH - Psychometrics MH - Young Adult MH - *Cooking MH - Canada MH - Adult MH - Food Preferences MH - Food Safety MH - Students/statistics & numerical data/psychology MH - Food Handling MH - *Nutritional Sciences/education OTO - NOTNLM OT - Culinary medicine OT - Food literacy OT - Food skills OT - Teaching kitchen OT - Validity EDAT- 2026/06/19 00:36 MHDA- 2026/09/18 23:36 CRDT- 2026/06/18 19:31 PHST- 2025/03/20 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/18 23:36 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 19:31 [entrez] AID - S2212-2672(26)00111-5 [pii] AID - 10.1016/j.jand.2026.156396 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Oct;126(10):156396. doi: 10.1016/j.jand.2026.156396. Epub 2026 Jun 18. PMID- 42313808 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Implementation research to develop and optimize delivery models for evidence-based anemia control interventions in India: Protocol for the precision-driven response for anemia control and sustainable health (PRAKASH) study. PG - e0351414 LID - 10.1371/journal.pone.0351414 [doi] LID - e0351414 AB - BACKGROUND: Government of India launched Anemia Mukt Bharat (AMB) program in 2018. Despite its implementation, the prevalence of anemia remains high. To address the gaps in coverage, adherence and effective implementation, the Indian Council of Medical Research (ICMR) initiated the Precision driven Response for Anemia Control and Sustainable Health (PRAKASH) study. It is an implementation research study aimed at co-developing and optimizing a district-level model of evidence-based anemia control interventions. The intended goal is to reduce anemia prevalence to 20% or lower through scalable, context-specific, and sustainable strategies. METHODS: This multi-site study targets six key population groups: children (aged 6-59 months and 5-9 years), adolescents boys and girls (10-19 years), women of reproductive age (20-49 years) and pregnant women. Interventions are anchored in six pillar i. Test-Treat-Track until resolution, ii. prophylactic iron and folic acid supplementation, ensuring high complianceiii. anemia-relevant health interventions, iv. fortified rice distribution, v. dietary diversification and promotion of iron-rich foods, and vi. behavior change communication through Jan Andolan. Anemia prevalence will be estimated through a series of community-based cross-sectional surveys. Mixed methods approach will be employed to assess barriers and enablers at the individual, household, facility, and community levels. The study will utilize implementation science frameworks, including Consolidated Framework for Implementation Research (CFIR) and Expert Recommendations for Implementing Change (ERIC), to guide iterative implementation, real-time model refinement, and monitoring of performance. Information on outcome indicators will be collected to evaluate anemia prevalence, fidelity, feasibility, and service delivery improvements. CONCLUSION: The study will try to readdress the implementation challenges across diverse regions and aims to develop a comprehensive and replicable model for the AMB 2.0 program. The study is likely to contribute to the global evidence base on implementation science for anemia reduction in low- and middle-income countries. CI - Copyright: (c) 2026 Bansal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Bansal, Priyanka Gupta AU - Bansal PG AUID- ORCID: 0000-0002-1058-0956 AD - Division of Reproductive, Child Health and Nutrition, Indian Council of Medical Research, New Delhi, India. FAU - Mazumder, Sarmila AU - Mazumder S AD - Society for Applied Studies, New Delhi, India. FAU - Sharma, Neeraj AU - Sharma N AUID- ORCID: 0000-0003-1006-6321 AD - Society for Applied Studies, New Delhi, India. FAU - Kulkarni, Ragini AU - Kulkarni R AD - Department of Operational and Implementation Research, Indian Council of Medical Research - National Institute for Research in Reproductive and Child Health, Mumbai, Maharashtra, India. FAU - Thankachan, Prashanth AU - Thankachan P AD - Division of Nutrition, St. John's Research Institute, Bangalore, Karnataka, India. FAU - Prasad, Pankaj AU - Prasad P AD - Department of Community and Family Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India. FAU - Panda, Bhuputra AU - Panda B AD - School of Public Health, KIIT Deemed to be University, Bhubaneswar, Odisha, India. FAU - Banjara, Santosh Kumar AU - Banjara SK AUID- ORCID: 0000-0002-0893-9552 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Chowdhury, Ranadip AU - Chowdhury R AD - Society for Applied Studies, New Delhi, India. FAU - Chandiok, Ketaki AU - Chandiok K AD - Division of Reproductive, Child Health and Nutrition, Indian Council of Medical Research, New Delhi, India. CN - Zaozianlungliu Gonmei CN - PRAKASH Study Group LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260618 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 935E97BOY8 (Folic Acid) RN - E1UOL152H7 (Iron) SB - IM MH - Adolescent MH - Adult MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Middle Aged MH - Pregnancy MH - Young Adult MH - *Anemia/prevention & control/epidemiology MH - Dietary Supplements MH - Folic Acid MH - India/epidemiology MH - Iron MH - Prevalence MH - Multicenter Studies as Topic MH - Observational Studies as Topic PMC - PMC13278398 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/18 18:32 MHDA- 2026/06/18 18:33 PMCR- 2026/06/18 CRDT- 2026/06/18 13:42 PHST- 2025/12/16 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/18 18:33 [medline] PHST- 2026/06/18 18:32 [pubmed] PHST- 2026/06/18 13:42 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - PONE-D-25-62936 [pii] AID - 10.1371/journal.pone.0351414 [doi] PST - epublish SO - PLoS One. 2026 Jun 18;21(6):e0351414. doi: 10.1371/journal.pone.0351414. eCollection 2026. PMID- 42313740 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - The validity and reliability of a biometrically accurate, photorealistic set of young adult body size scales based on 3D scans of White Europeans. PG - e0351658 LID - 10.1371/journal.pone.0351658 [doi] LID - e0351658 AB - Young adults are a high-risk group for weight-related health problems but are often overlooked in weight management intervention design. Validated visual tools that accurately depict body size are needed to improve communication and intervention strategies. This study validated innovative, photo-realistic, gender-specific body size scales of young adults (aged 18), created from 3D scans to depict systematic changes in adiposity. A total of 110 young adults (aged 18-25) completed two behavioural tasks: (1) estimating the relative size of the bodies and (2) ranking them in ascending order of weight. To assess reliability, participants repeated the tasks three days later. Participants accurately estimated relative body sizes and ranked the images in line with the systematic BMI changes across the scales. Test-retest analyses showed good to excellent reliability for both tasks. The young adult body size scales are anthropometrically accurate, reliable, and valid tools for body size estimation tasks. They provide a robust resource for research, clinical communication, and intervention design focused on young adults. CI - Copyright: (c) 2026 Ridley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ridley, Bethany J AU - Ridley BJ AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Cornelissen, Piers L AU - Cornelissen PL AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Kramer, Robin S S AU - Kramer RSS AD - School of Psychology, Sport Science and Wellbeing, University of Lincoln, Lincoln, United Kingdom. FAU - Maalin, Nadia AU - Maalin N AUID- ORCID: 0000-0001-7055-1658 AD - Department of Psychology and Counselling, Birmingham City University, Birmingham, United Kingdom. FAU - Mohamed, Sophie AU - Mohamed S AD - Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, United Kingdom. FAU - Tovee, Martin J AU - Tovee MJ AUID- ORCID: 0000-0001-9642-4462 AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. LA - eng PT - Journal Article PT - Validation Study DEP - 20260618 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Male MH - *Body Size MH - Young Adult MH - Adult MH - Adolescent MH - Reproducibility of Results MH - *Imaging, Three-Dimensional/methods MH - White People MH - Body Mass Index MH - *Anthropometry/methods PMC - PMC13278476 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/18 18:33 MHDA- 2026/06/18 18:34 PMCR- 2026/06/18 CRDT- 2026/06/18 13:33 PHST- 2025/10/23 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/18 18:34 [medline] PHST- 2026/06/18 18:33 [pubmed] PHST- 2026/06/18 13:33 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - PONE-D-25-54538 [pii] AID - 10.1371/journal.pone.0351658 [doi] PST - epublish SO - PLoS One. 2026 Jun 18;21(6):e0351658. doi: 10.1371/journal.pone.0351658. eCollection 2026. PMID- 42312730 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 1520-5851 (Electronic) IS - 0013-936X (Linking) VI - 60 IP - 25 DP - 2026 Jun 30 TI - A Multitracer Reconciliation Approach for Estimating Child-Specific Dust and Soil Ingestion Rates. PG - 17574-17585 LID - 10.1021/acs.est.5c14979 [doi] AB - Reliable quantification of children's ingestion of dust and soil is essential for accurate exposure and risk assessment. Yet, most existing estimation strategies, typically relying on a single tracer element or evaluating multiple tracers independently, suffer from measurement uncertainties, the burdensome collection of excreta volumes, incomplete accounting of exposure and elimination pathways, reliance on population-average assumptions, and the inability to distinguish dust ingestion from soil ingestion. To address these limitations, we develop a novel "multitracer" reconciliation approach that estimates individual-level ingestion rates of dust and soil particles by jointly using concurrent measurements of multiple elements in dust, soil, urine, and fecal samples and mathematically identifying the physiologically plausible solution that best satisfies all tracer-specific mass-balance equations simultaneously. This approach supports deriving personalized dust and soil ingestion rates that maintain physiological plausibility while minimizing inconsistencies across tracers. Applied to 112 U.S. children representing diverse demographic backgrounds, our approach produced estimates of dust, soil, and "combined" dust and soil ingestion rates (medians: 38, 10, and 75 mg/day, respectively; the sum of dust and soil medians differs from the "combined" median because individual children had varying relative contributions from dust and soil). These estimates agree with reference values provided in the U.S. EPA's Exposure Factors Handbook. Ingestion patterns varied with age, season, race/ethnicity, and body-mass-index category. This multitracer reconciliation framework provides a data-driven foundation for reducing uncertainty in exposure factors and refining child-specific risk characterization. FAU - Li, Yongcheng AU - Li Y AUID- ORCID: 0009-0005-3448-8950 AD - School of Public Health, University of Nevada, Reno, Reno, Nevada 89557, United States. AD - Desert Research Institute, Reno, Nevada 89512, United States. FAU - Dina, Olufunke AU - Dina O AD - Desert Research Institute, Reno, Nevada 89512, United States. FAU - Fu, You AU - Fu Y AD - School of Public Health, University of Nevada, Reno, Reno, Nevada 89557, United States. FAU - Son, Yeongkwon AU - Son Y AUID- ORCID: 0000-0002-4773-6838 AD - Desert Research Institute, Reno, Nevada 89512, United States. FAU - Hurbain, Patrick AU - Hurbain P AUID- ORCID: 0000-0002-5660-3279 AD - School of Public Health, University of Nevada, Reno, Reno, Nevada 89557, United States. AD - Desert Research Institute, Reno, Nevada 89512, United States. FAU - Li, Dingsheng AU - Li D AUID- ORCID: 0000-0002-8432-4023 AD - School of Public Health, University of Nevada, Reno, Reno, Nevada 89557, United States. FAU - Li, Li AU - Li L AUID- ORCID: 0000-0002-5157-7366 AD - School of Public Health, University of Nevada, Reno, Reno, Nevada 89557, United States. LA - eng PT - Journal Article DEP - 20260618 PL - United States TA - Environ Sci Technol JT - Environmental science & technology JID - 0213155 RN - 0 (Dust) RN - 0 (Soil) SB - IM MH - *Dust/analysis MH - Humans MH - *Soil MH - Child MH - Environmental Exposure OTO - NOTNLM OT - child health OT - dust OT - ingestion OT - soil OT - tracer EDAT- 2026/06/18 12:33 MHDA- 2026/06/30 06:31 CRDT- 2026/06/18 08:22 PHST- 2026/06/30 06:31 [medline] PHST- 2026/06/18 12:33 [pubmed] PHST- 2026/06/18 08:22 [entrez] AID - 10.1021/acs.est.5c14979 [doi] PST - ppublish SO - Environ Sci Technol. 2026 Jun 30;60(25):17574-17585. doi: 10.1021/acs.est.5c14979. Epub 2026 Jun 18. PMID- 42312671 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260910 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Jun 18 TI - Development and validation of the Brazilian Dietary Guidelines Adherence Score (BraScore): a novel index to assess the adherence to the Dietary Guidelines for the Brazilian Population. PG - e141 LID - 10.1017/S1368980026102936 [doi] LID - e141 AB - OBJECTIVE: We aimed to describe the development and evaluation of the Brazilian Dietary Guidelines Adherence Score (BraScore). DESIGN: The process comprised multiple steps: defining guiding principles, identifying food components, setting scoring cut-off points and assessing validity and reliability. SETTING: Nationally representative sample of the Brazilian population. PARTICIPANTS: 46 164 Brazilians aged >/= 10 years. RESULTS: The BraScore has ten components: to be consumed (legumes; fruits; vegetables and diversity), to be limited (red meat; other animal-based foods; processed foods; table sugar and cooking salt) and to be avoided (ultra-processed foods). Scores range from 0 to 100, with higher values indicating greater adherence to the Dietary Guidelines. Analyses showed a weak correlation with energy intake (coefficient: -0.12) and substantial variability among individuals (1st percentile: 20.5; 99th: 77.7). Scree plot analysis revealed multidimensionality, indicating four distinct patterns. The scores differentiated population groups (older adults and rural residents had higher scores) and were high for diets developed by nutritionists (84.6-97.6 points). The reliability analysis yielded a coefficient of 0.6, suggesting acceptable internal consistency. CONCLUSIONS: The BraScore is a valid and reliable tool to assess adherence to the Dietary Guidelines for the Brazilian Population. FAU - Souza, Thays Nascimento AU - Souza TN AUID- ORCID: 0000-0001-5405-5398 AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. FAU - Gabe, Kamila Tiemann AU - Gabe KT AUID- ORCID: 0000-0001-5138-9552 AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. FAU - Cacau, Leandro Teixeira AU - Cacau LT AUID- ORCID: 0000-0003-1681-5960 AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. FAU - Carneiro, Leticia Barroso Vertulli AU - Carneiro LBV AUID- ORCID: 0000-0003-0832-2293 AD - Universidade Federal do Rio de Janeiro, Instituto de Estudos em Saude Coletiva, Brazil. FAU - Lassale, Camille AU - Lassale C AD - Barcelona Institute for Global Health, Spain. AD - Pompeu Fabra University, Spain. AD - Instituto de Salud Carlos III, Spain. FAU - Levy, Renata Bertazzi AU - Levy RB AUID- ORCID: 0000-0001-5388-7002 AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Department of Preventive Medicine, University of Sao Paulo, Brazil. AD - Institute for Biomedical Research of Salamanca, Spain. FAU - Castro, Ines Rugani Ribeiro de AU - Castro IRR AD - Universidade Estadual do Rio de Janeiro, Brazil. FAU - Louzada, Maria Laura da Costa AU - Louzada MLDC AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20260618 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Brazil MH - *Nutrition Policy MH - Female MH - Adult MH - Reproducibility of Results MH - Middle Aged MH - Male MH - Child MH - *Diet/standards/statistics & numerical data MH - Young Adult MH - Adolescent MH - *Guideline Adherence/statistics & numerical data MH - Aged MH - *Diet Surveys MH - Energy Intake PMC - PMC13434578 OTO - NOTNLM OT - Diet index OT - Food guide OT - Healthy eating indices OT - Nutritional epidemiology OT - Ultra-processed foods COIS- There are no conflicts of interest. EDAT- 2026/06/18 12:33 MHDA- 2026/07/11 01:09 PMCR- 2026/06/18 CRDT- 2026/06/18 07:34 PHST- 2026/07/11 01:09 [medline] PHST- 2026/06/18 12:33 [pubmed] PHST- 2026/06/18 07:34 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - S1368980026102936 [pii] AID - 10.1017/S1368980026102936 [doi] PST - epublish SO - Public Health Nutr. 2026 Jun 18;29(1):e141. doi: 10.1017/S1368980026102936. PMID- 42312484 OWN - NLM STAT- Publisher LR - 20260618 IS - 1557-1246 (Electronic) IS - 1087-0547 (Linking) DP - 2026 Jun 18 TI - Association of Inflammatory Biomarkers With ADHD and Moderating Effect of Leisure-Time Physical Activity in Adolescents: A Cross-Sectional Study Based on NHANES. PG - 10870547261458103 LID - 10.1177/10870547261458103 [doi] AB - INTRODUCTION: Research findings on specific inflammatory markers (e.g., CRP) in ADHD show considerable heterogeneity. Meanwhile, the potential moderating role of leisure-time physical activity (LTPA) in this relationship is underexplored. METHODS: Based on data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2004, 4,817 adolescents aged 12 to 19 were included. This study used logistic regression analysis and restricted cubic splines (RCS) to explore the association between inflammatory biomarkers and ADHD. Interactive analyses were performed to assess the moderating effect of LTPA on this relationship. Furthermore, subgroup analyses were conducted to validate the robustness of the observed effects. RESULTS: After adjusting for all confounding factors, each 1 mg/L increment in C-reactive protein (CRP) was associated with a 9% higher ADHD risk (OR = 1.09, 95% CI [1.01, 1.18]). The chronic low-grade inflammation (CLGI) group exhibited a 57% higher risk of ADHD (OR = 1.57, 95% CI [1.14, 2.15]) compared to the non-GLGI group. The non-linear analysis further revealed that the risk of ADHD reached its peak when CRP was 2.75 mg/L (OR = 1.89, 95% CI [1.39, 2.57]). Compared with the group engaging in less than 60 min of LTPA daily, the association between ADHD and CRP was moderated in the "LTPA >/=60 min/day" group (p for interaction = .04). CONCLUSIONS: Elevated CRP levels are positively associated with ADHD. More than 60 min/day LTPA may moderate the association between CRP and the risk of ADHD. FAU - Pan, Keyu AU - Pan K AUID- ORCID: 0009-0004-9716-7970 AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Jin, Shanru AU - Jin S AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Gao, Xiang AU - Gao X AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - He, Changshuang AU - He C AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Shi, Beibei AU - Shi B AD - School of Exercise and Health, Shanghai University of Sport, China. AD - School of Physical Education, Shandong University, China. FAU - Zhang, Meng AU - Zhang M AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Wei, Yiting AU - Wei Y AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Quan, Minghui AU - Quan M AD - School of Exercise and Health, Shanghai University of Sport, China. LA - eng PT - Journal Article DEP - 20260618 PL - United States TA - J Atten Disord JT - Journal of attention disorders JID - 9615686 SB - IM OTO - NOTNLM OT - ADHD OT - CLGI OT - CRP OT - LTPA OT - inflammatory biomarkers EDAT- 2026/06/18 06:31 MHDA- 2026/06/18 06:31 CRDT- 2026/06/18 05:53 PHST- 2026/06/18 06:31 [medline] PHST- 2026/06/18 06:31 [pubmed] PHST- 2026/06/18 05:53 [entrez] AID - 10.1177/10870547261458103 [doi] PST - aheadofprint SO - J Atten Disord. 2026 Jun 18:10870547261458103. doi: 10.1177/10870547261458103. PMID- 42312269 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260618 LR - 20260813 IS - 0971-9261 (Print) IS - 1998-3891 (Electronic) IS - 0971-9261 (Linking) VI - 31 IP - 3 DP - 2026 May-Jun TI - Outcomes of Silver Nitrate Application in the Treatment of Pilonidal Sinus Disease in Children. PG - 369-371 LID - 10.4103/jiaps.jiaps_312_25 [doi] AB - OBJECTIVE: This study aimed to retrospectively evaluate the clinical outcomes, recurrence rates, and safety profile of silver nitrate application in pediatric patients diagnosed with pilonidal sinus disease, with a minimum follow-up of 12 months. MATERIALS AND METHODS: Pediatric patients diagnosed with pilonidal sinus disease and treated with silver nitrate between January 2024 and January 2025 were retrospectively reviewed. Demographic features, comorbidities, body mass index (BMI), number of sinus openings, treatment duration, number of applications, complications, and recurrence rates were recorded. A maximum of four weekly applications was planned. Absence of discharge or swelling at the end of treatment and sustained symptom-free status during follow-up were considered successful outcomes. This study was approved by the Institutional Ethics Committee (Approval No: 2024-KAEK-39), and informed consent was obtained from patient's guardians. Clinical follow-up was conducted at 1, 3, 6, and 12 months posttreatment. RESULTS: A total of 49 patients were included (20 males, 40.8%; 29 females, 59.2%) with a mean age of 15.5 years (range: 13-17). The average number of sinus openings was 2.04. Complete healing was achieved in 42 patients (85.7%), while seven patients (14.3%) required surgical intervention due to persistent discharge after four applications. The mean number of silver nitrate applications required for complete healing was 3.1. Mean BMI was 22.4, and no significant comorbidities were observed. No acute complications such as infection, bleeding, skin irritation, or seroma were observed, and a monitoring protocol for adverse events was followed. During the 12-month follow-up period, no recurrences were detected. CONCLUSION: Silver nitrate application represents a safe, effective, minimally invasive, and cost-efficient treatment modality for pilonidal sinus disease in children. The absence of recurrence in the 12-month follow-up suggests that silver nitrate may serve as a reliable first-line conservative management strategy before surgical intervention is considered. CI - Copyright: (c) 2026 Journal of Indian Association of Pediatric Surgeons. FAU - Telsiz, Filiz Gunduz AU - Telsiz FG AD - Department of Pediatric Surgery, Gaziantep Cengiz Gokcek Maternity and Children's Hospital, Gaziantep, Turkey. LA - eng PT - Journal Article DEP - 20260505 PL - India TA - J Indian Assoc Pediatr Surg JT - Journal of Indian Association of Pediatric Surgeons JID - 101179870 PMC - PMC13271697 OTO - NOTNLM OT - Children OT - minimally invasive treatment OT - pilonidal sinus OT - recurrence OT - silver nitrate COIS- There are no conflicts of interest. EDAT- 2026/06/18 06:32 MHDA- 2026/06/18 06:33 PMCR- 2026/05/01 CRDT- 2026/06/18 04:46 PHST- 2025/09/03 00:00 [received] PHST- 2025/10/20 00:00 [revised] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/06/18 06:33 [medline] PHST- 2026/06/18 06:32 [pubmed] PHST- 2026/06/18 04:46 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - JIAPS-31-369 [pii] AID - 10.4103/jiaps.jiaps_312_25 [doi] PST - ppublish SO - J Indian Assoc Pediatr Surg. 2026 May-Jun;31(3):369-371. doi: 10.4103/jiaps.jiaps_312_25. Epub 2026 May 5. PMID- 42312170 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260618 LR - 20260813 IS - 2575-9108 (Electronic) IS - 2575-9108 (Linking) VI - 9 IP - 6 DP - 2026 Jun 12 TI - Age-Driven Physiologically Based Pharmacokinetic Modeling of Empagliflozin: Toward Precision Dosing in Youth. PG - 1412-1425 LID - 10.1021/acsptsci.5c00772 [doi] AB - Type 2 diabetes mellitus (T2DM) is a multifactorial disease that affects both adults and children. Treating T2DM in children poses a challenge because of the difficulties in conducting clinical trials in this special population. Empagliflozin (EMPA) is an antidiabetic drug belonging to the class of sodium-glucose cotransporter 2 (SGLT2) inhibitors and reversibly inhibits glucose reabsorption in the proximal tubules of the kidneys. This drug is a great candidate for treating T2DM in children due to its action on diabetes and other effects such as cardio- and nephroprotection. Despite its therapeutic advantages, the most appropriate dose for the treatment of T2DM in children is still unknown. In this context, new methodological approaches (NAMs) are necessary to overcome these obstacles. Physiologically based pharmacokinetic modeling (PBPK) emerges as a promising and regulatory-accepted approach that can be used to predict the most suitable dose for children. Therefore, the aim of this study was to construct the PBPK model for the oral administration of EMPA in children with healthy and obese weights. Following a literature search, pharmacokinetic and physicochemical parameters of the drug, along with physiological characteristics from selected studies for validation, were obtained for the model development. A PBPK model of EMPA was developed and verified in the adult population by comparing the simulated plasma exposure to the observed data. After validation for healthy adults, the model was scaled for children with healthy and obese weights according to the WHO metrics. The parameters that showed the most significant changes were the C (max) and AUC values. In children with healthy weights, C (max) was 1.93 and 1.39 times higher in the 10-12 year-old and 13-14 year-old groups, respectively, compared to adults receiving a 10 mg dose. Similarly, AUC increased by 1.81 and 1.48 times in the 10-12 year-old and 13-14 year-old groups, respectively, among healthy children. In obese children aged 10-12, C (max) and AUC were altered, showing increases of 1.77 and 1.81 times, respectively. The developed and validated empagliflozin PBPK model in adults provided a robust basis for extending research to pediatric populations. Simulations indicated the need for dose adjustments in pediatric patients, particularly for healthy children aged 10-14 and obese children aged 10-12. These adjustments are essential to minimizing adverse effects, ensuring the safe and effective use of empagliflozin in these age groups. CI - (c) 2026 The Authors. Published by American Chemical Society. FAU - Milhm, Gabriela Pereira AU - Milhm GP AUID- ORCID: 0009-0007-4517-5305 AD - Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho, 373, bloco L subsolo, Cidade Universitaria, Rio de Janeiro, Brazil 21941-902. FAU - Moreira, Fernanda de Lima AU - Moreira FL AUID- ORCID: 0000-0001-7699-2665 AD - Laboratory of Pharmacometrics, Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil 21941-902. FAU - Abrahim-Vieira, Barbara de Azevedo AU - Abrahim-Vieira BA AUID- ORCID: 0000-0001-6444-0169 AD - Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho, 373, bloco L subsolo, Cidade Universitaria, Rio de Janeiro, Brazil 21941-902. LA - eng PT - Journal Article DEP - 20260529 PL - United States TA - ACS Pharmacol Transl Sci JT - ACS pharmacology & translational science JID - 101721411 PMC - PMC13270446 OTO - NOTNLM OT - PBPK (physiologically based pharmacokinetic model) OT - SGLT2 (sodium-glucose cotransporter 2) OT - T2DM OT - empagliflozin OT - pediatric OT - type 2 diabetes mellitus EDAT- 2026/06/18 06:32 MHDA- 2026/06/18 06:33 PMCR- 2026/05/29 CRDT- 2026/06/18 04:45 PHST- 2025/11/26 00:00 [received] PHST- 2026/05/06 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/18 06:33 [medline] PHST- 2026/06/18 06:32 [pubmed] PHST- 2026/06/18 04:45 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.1021/acsptsci.5c00772 [doi] PST - epublish SO - ACS Pharmacol Transl Sci. 2026 May 29;9(6):1412-1425. doi: 10.1021/acsptsci.5c00772. eCollection 2026 Jun 12. PMID- 42311940 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260618 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Comparing food literacy by grade, sex, and food education exposure: construct validation of the food literacy BITE scale. PG - 1819437 LID - 10.3389/fnut.2026.1819437 [doi] LID - 1819437 AB - BACKGROUND: Food literacy provides a framework for understanding dietary behaviors in children and can inform priorities for and evaluate the effectiveness of food education interventions. The 4-dimension Food Literacy BITE scale is built on a child-centered food literacy framework and has been structurally validated in U.S. elementary schoolchildren. We conducted additional validity testing to assess the tool's generalizability, ability to differentiate mean food literacy by grade, sex, and food education exposure, and the association of food literacy score with food group consumption frequencies. MATERIALS AND METHODS: We administered the Food Literacy BITE scale and food frequency questionnaires to n = 690 4 (th) and 5 (th) -grade students from 10 elementary schools in Washington, DC, and Kentucky (52.5% 4 (th) grade, 55.8% 4+ years of food education, 52.8% girls). Stepwise series of multiple-group confirmatory factor analysis models assessed measurement invariance by grade, sex, and school-level food education history. We examined group differences in overall food literacy score and dimension scores using latent means and used multilevel modeling for the food education exposure analysis to account for clustering within schools. We used weighted regression with robust standard errors to investigate associations between food literacy scores and food group consumption frequencies, aggregated by school and grade (n = 20). RESULTS: Item interpretation was consistent across groups, with full scalar invariance established by grade and partial scalar invariance by sex and food education history (4+years vs. new/none). Girls scored higher than boys in the "confidence in everyday food skills" dimension (p = 0.03). Mean food literacy was higher in the group from schools offering 4+ years of experiential food education (p = 0.03), driven by higher scores in the "valuing shared food experiences" (p = 0.02) and "food systems and nutrition knowledge" (p = 0.04) dimensions. In the multilevel models, only the difference in "valuing shared food experiences" remained significant. CONCLUSION: Results support generalizable use of the Food Literacy BITE scale in the U.S. and areas with similar food practices and environments. The tool's ability to differentiate between food education exposure history suggests it may be useful in identifying best practices for food education interventions targeting late childhood. CI - Copyright (c) 2026 St. Pierre, Bingenheimer, van Dam and Sacheck. FAU - St Pierre, Christine AU - St Pierre C AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. FAU - Bingenheimer, Jeffrey B AU - Bingenheimer JB AD - Department of Prevention and Community Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. FAU - van Dam, Rob M AU - van Dam RM AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. FAU - Sacheck, Jennifer M AU - Sacheck JM AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. AD - Department of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, RI, United States. LA - eng PT - Journal Article DEP - 20260602 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13268878 OTO - NOTNLM OT - children OT - food education OT - food literacy OT - measurement properties OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/18 06:32 MHDA- 2026/06/18 06:33 PMCR- 2026/06/02 CRDT- 2026/06/18 04:42 PHST- 2026/02/27 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/18 06:33 [medline] PHST- 2026/06/18 06:32 [pubmed] PHST- 2026/06/18 04:42 [entrez] PHST- 2026/06/02 00:00 [pmc-release] AID - 10.3389/fnut.2026.1819437 [doi] PST - epublish SO - Front Nutr. 2026 Jun 2;13:1819437. doi: 10.3389/fnut.2026.1819437. eCollection 2026. PMID- 42310262 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260910 IS - 1573-6628 (Electronic) IS - 1092-7875 (Print) IS - 1092-7875 (Linking) VI - 30 IP - 8 DP - 2026 Aug TI - Baby-Feed Pilot Trial for Improving Diet and Weight Gain in Infants and Toddlers. PG - 1017-1027 LID - 10.1007/s10995-026-04282-z [doi] AB - OBJECTIVE: To pilot test the initial efficacy of the Baby-Feed website for improving infant diet quality (main outcome) and weight gain (exploratory outcome) compared to usual care. METHODS: This was a 3-month randomized clinical trial, in which two healthcare providers and 50 caregivers of healthy-term infants (4-12 months) in a community health center were recruited. Participants were randomized to usual care or access to the Baby-Feed website, which assesses infants' diets, provides automated results, and delivers feedback. Measures were assessed at baseline and at the end of the study: diet quality from a validated infant food frequency questionnaire (FFQ), self-reported weight/length to calculate rate of weight gain, and a validated self-efficacy questionnaire. Changes were compared using analysis of covariance or Chi-square/Fisher's Exact test. RESULTS: Baseline characteristics were similar between groups (n = 25 intervention; n = 25 control). Most caregivers were mothers (92%) and Hispanic (86%). Change in total diet quality scores was higher in the intervention (-2.95 +/- 6.53) vs. controls (-7.69 +/- 7.84; p = 0.031). Healthy weight gain was higher in the intervention group (n = 21, 95%) vs. controls (n = 14, 58%; p = 0.006). Changes in the self-efficacy score for promoting healthy foods were associated with changes in the fruit score (r = 0.46; p = 0.03), and changes in the self-efficacy score for limiting unhealthy foods were associated with changes in the juice score (r = 0.45; p = 0.04) only in the intervention group. CONCLUSIONS: Using Baby-Feed for 3 months improved diet quality and the rate of weight gain compared with controls in this small and short pilot trial. A larger, longer trial with a more diverse population is needed to confirm the results. TRIAL REGISTRY: https://clinicaltrials.gov/ : NCT05062824. CI - (c) 2026. The Author(s). FAU - Bolton, Jennifer AU - Bolton J AUID- ORCID: 0000-0002-8324-9113 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Wang, Wenjia AU - Wang W AUID- ORCID: 0000-0002-1967-0405 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. AD - Vertically Integrated Projects, Knight Foundation School of Computing and Information Sciences, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA. FAU - Coccia, Catherine AU - Coccia C AUID- ORCID: 0000-0002-8086-4479 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Narayanan, Vijaya AU - Narayanan V AUID- ORCID: 0009-0003-6685-1430 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Varella, Marcia AU - Varella M AUID- ORCID: 0000-0003-2626-8825 AD - Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street AHC1, Miami, FL, 33199, USA. FAU - Hannan, Jean AU - Hannan J AUID- ORCID: 0000-0003-3740-620X AD - Nicole Wertheim College of Nursing & Health Sciences, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Palacios, Cristina AU - Palacios C AUID- ORCID: 0000-0001-9437-0376 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. crpalaci@fiu.edu. AD - Department of Dietetics and Nutrition in the Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street, AHC 5-313, Miami, 33199, FL, USA. crpalaci@fiu.edu. LA - eng SI - ClinicalTrials.gov/NCT05062824 GR - Children's Trust/Children's Trust/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260618 PL - United States TA - Matern Child Health J JT - Maternal and child health journal JID - 9715672 SB - IM MH - Humans MH - Infant MH - *Weight Gain/physiology MH - Pilot Projects MH - Female MH - Male MH - *Diet/standards MH - *Infant Food MH - Surveys and Questionnaires MH - Infant Nutritional Physiological Phenomena MH - Internet PMC - PMC13503433 OTO - NOTNLM OT - Diet quality OT - Infant OT - Intervention OT - Website OT - Weight gain COIS- Declarations. Competing Interests: The authors have not disclosed any competing interests. Ethical Approval: Study procedures were approved by the IRB at Florida International University (Protocol Number: 20-0498). Data Sharing: Deidentified individual participant data (including the data dictionary) underlying the results reported in this study will be made available upon reasonable request to the corresponding author. EDAT- 2026/06/18 00:31 MHDA- 2026/08/25 05:34 PMCR- 2026/06/18 CRDT- 2026/06/17 23:26 PHST- 2025/03/08 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/06/18 00:31 [pubmed] PHST- 2026/06/17 23:26 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1007/s10995-026-04282-z [pii] AID - 4282 [pii] AID - 10.1007/s10995-026-04282-z [doi] PST - ppublish SO - Matern Child Health J. 2026 Aug;30(8):1017-1027. doi: 10.1007/s10995-026-04282-z. Epub 2026 Jun 18. PMID- 42310167 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260831 LR - 20260903 IS - 2731-4383 (Electronic) IS - 2731-4383 (Linking) VI - 6 IP - 1 DP - 2026 Jun 17 TI - A is for ___ : Narrative Medicine Framework for Mental Health Empowerment and Self-Authorship in Asian American Communities. LID - 10.1007/s44192-026-00490-9 [doi] LID - 164 AB - Mental health stigma and underutilization of psychiatric care remain significant challenges in Asian American, Native Hawaiian, and Pacific Islander (AANHPI) communities, driven by cultural norms of silence, the model minority myth, and structural barriers to care. Narrative medicine, a clinical approach that utilizes storytelling, reflective writing, and deep listening, offers a promising approach to address these challenges by centering identity, voice, and meaning making in mental health engagement, processes that are foundational to psychological healing. In this Perspective, we describe "A is for ___", a novel narrative medicine-based empowerment framework developed through A-Team Med, a community-based nonprofit organization. The framework is left intentionally blank to symbolize the tremendous diversity of the AANHPI experience and counter monolithic representations of Asian American identity. Applied in community settings, the framework invites participants to complete the prompt "A is for ___" by selecting a personally meaningful word beginning with the letter "A" that reflects the individual's AANHPI lived experience. This open-ended structure serves as an accessible entry point for self-authorship, critical reflection, and dialogue about the AANHPI experience and mental health topics traditionally underdiscussed within this community. We situate this intervention within theories of narrative identity, cultural psychiatry, and the social determinants of mental health. We describe the implementation of this framework in a community workshop with over 50 AANHPI adolescents across multiple underserved community centers in Los Angeles. Author observations of participant experiences suggest that the exercise facilitated emotional expression, reduced stigma surrounding mental health conversations, and fostered validation and a sense of belonging. We further discuss practical applications of this framework in clinical encounters, community psychoeducation, and youth programs, as well as its potential for digital and telehealth adaptation. By reframing mental health engagement through narrative agency rather than pathology, "A is for ___" offers a low-cost, scalable, and culturally responsive tool to support mental health destigmatization and empowerment in AANHPI and other marginalized communities. CI - (c) 2026. The Author(s). FAU - Yan, Matthew J AU - Yan MJ AUID- ORCID: 0000-0001-8301-1941 AD - A-Team Med, Los Angeles, CA, USA. matthewyan@mednet.ucla.edu. AD - , . matthewyan@mednet.ucla.edu. AD - David Geffen School of Medicine, University of California, Los Angeles (UCLA), 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. matthewyan@mednet.ucla.edu. AD - Harvard Business School, Boston, MA, USA. matthewyan@mednet.ucla.edu. AD - Department of Stem Cell and Regenerative Biology, Harvard Graduate School of Arts and Sciences, Boston, MA, USA. matthewyan@mednet.ucla.edu. AD - Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, MA, USA. matthewyan@mednet.ucla.edu. FAU - Lee, Hannah J AU - Lee HJ AD - A-Team Med, Los Angeles, CA, USA. AD - . AD - David Geffen School of Medicine, University of California, Los Angeles (UCLA), 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. AD - Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA. FAU - Yan, Alexander J AU - Yan AJ AD - A-Team Med, Los Angeles, CA, USA. AD - . FAU - Yan, Victoria C AU - Yan VC AUID- ORCID: 0000-0003-0837-5184 AD - A-Team Med, Los Angeles, CA, USA. AD - . AD - University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Bahk, Jason E AU - Bahk JE AD - A-Team Med, Los Angeles, CA, USA. AD - . AD - David Geffen School of Medicine, University of California, Los Angeles (UCLA), 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. FAU - Chen, Justin A AU - Chen JA AUID- ORCID: 0000-0002-1504-0094 AD - Department of Psychiatry, Weill Cornell Medicine/New York-Presbyterian, New York, NY, USA. FAU - Trinh, Nhi-Ha T AU - Trinh NT AUID- ORCID: 0000-0001-7812-9187 AD - Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. FAU - Ng, Warren Y K AU - Ng WYK AD - Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, USA. FAU - Lu, Francis G AU - Lu FG AUID- ORCID: 0000-0002-2032-2379 AD - Department of Psychiatry, University of California Davis, Davis, CA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260617 PL - Switzerland TA - Discov Ment Health JT - Discover mental health JID - 9918350483906676 PMC - PMC13530052 OTO - NOTNLM OT - A is for ___ OT - A-Team Med OT - AANHPI OT - Asian American OT - Community health OT - Cultural psychiatry OT - Destigmatization OT - Empowerment OT - Identity OT - Mental health OT - Narrative medicine OT - Public health OT - Self-authorship OT - Storytelling COIS- Declarations. Ethics approval and consent to participate: This manuscript is a Perspective article and does not involve human subjects research. No identifiable participant data were collected or analyzed. As such, ethical approval was not required. Consent for publication: Not applicable. This manuscript does not include patient data, personal identifiers, or images requiring consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/06/18 00:31 MHDA- 2026/06/18 00:32 PMCR- 2026/06/17 CRDT- 2026/06/17 23:22 PHST- 2025/10/21 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/06/18 00:32 [medline] PHST- 2026/06/18 00:31 [pubmed] PHST- 2026/06/17 23:22 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - 10.1007/s44192-026-00490-9 [pii] AID - 490 [pii] AID - 10.1007/s44192-026-00490-9 [doi] PST - epublish SO - Discov Ment Health. 2026 Jun 17;6(1):164. doi: 10.1007/s44192-026-00490-9. PMID- 42309860 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 2255-534X (Electronic) IS - 2255-534X (Linking) VI - 91 IP - 2 DP - 2026 Apr-Jun TI - Clinical guideline of the Asociacion Mexicana de Gastroenterologia for the diagnosis and treatment of lactose ingestion-related disorders. PG - 231-253 LID - S2255-534X(26)00063-0 [pii] LID - 10.1016/j.rgmxen.2026.02.002 [doi] AB - The aim of the present Clinical Guideline of the Asociacion Mexicana de Gastroenterologia was to establish clear, updated, evidence-based recommendations for the diagnosis and treatment of lactose ingestion-related disorders (LIRDs), to improve diagnostic accuracy and promote effective, patient-centered clinical management. The methodology employed consisted of a Delphi process coordinated by three experts, with the participation of 15 Mexican specialists (gastroenterologists, pediatricians, and nutritionists). Three working groups (epidemiology/definitions, diagnosis, and treatment) were formed that thoroughly reviewed the medical literature published between 2010 and 2025. A total of 26 statements were formulated. The main results included the precise definition of the different LIRD phenotypes (lactase nonpersistence, hypolactasia, clinical lactose intolerance, self-perceived lactose intolerance, and lactose sensitivity); diagnostic test standardization, highlighting the lactose breath test as a highly sensitive noninvasive tool, complemented by genetic studies and biochemical tests; and the recommendation of personalized treatments ranging from the selective reduction of dietary lactose to the use of exogenous enzymes (lactase) and fermented dairy products. Likewise, the importance of avoiding unnecessary dietary restrictions that could compromise calcium and vitamin D intake was emphasized. Altogether, the present consensus provides a comprehensive framework to optimize the clinical care of patients with LIRDs in Mexico. CI - Copyright (c) 2026. Published by Masson Doyma Mexico S.A. FAU - Remes-Troche, J M AU - Remes-Troche JM AD - Laboratorio de Fisiologia Digestiva y Motilidad Gastrointestinal, Instituto de Investigaciones Medico Biologicas, Universidad Veracruzana, Veracruz, Mexico. Electronic address: jose.remes.troche@gmail.com. FAU - Amieva-Balmori, M AU - Amieva-Balmori M AD - Laboratorio de Fisiologia Digestiva y Motilidad Gastrointestinal, Instituto de Investigaciones Medico Biologicas, Universidad Veracruzana, Veracruz, Mexico. FAU - Uscanga-Dominguez, L F AU - Uscanga-Dominguez LF AD - Departamento de Gastroenterologia y Laboratorio de Motilidad Gastrointestinal, Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Mexico City, Mexico. FAU - Coss-Adame, E AU - Coss-Adame E AD - Departamento de Gastroenterologia y Laboratorio de Motilidad Gastrointestinal, Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Mexico City, Mexico. FAU - Bernal-Reyes, R AU - Bernal-Reyes R AD - Medica Delta, Pachuca, Hidalgo, Mexico. FAU - Carmona-Sanchez, R AU - Carmona-Sanchez R AD - Practica Privada, San Luis Potosi, Mexico. FAU - Francisco, M R AU - Francisco MR AD - Laboratorio de Fisiologia Digestiva y Motilidad Gastrointestinal, Instituto de Investigaciones Medico Biologicas, Universidad Veracruzana, Veracruz, Mexico. FAU - Garcia-Zermeno, K R AU - Garcia-Zermeno KR AD - Centro Integral de Gastroenterologia y Motilidad Avanzada (CIGMA), Boca del Rio, Veracruz, Mexico. FAU - Gomez-Castanos, P C AU - Gomez-Castanos PC AD - Centro de Investigacion y Docencia en Ciencias de la Salud, Universidad Autonoma de Sinaloa, Sinaloa, Mexico. FAU - Gomez-Escudero, O AU - Gomez-Escudero O AD - Clinica de Gastroenterologia, Endoscopia Digestiva y Motilidad Gastrointestinal, Hospital Angeles de Puebla, Puebla, Mexico. FAU - Huerta de la Torre, M F AU - Huerta de la Torre MF AD - Hospital Angeles de Torreon, Mexico. FAU - Icaza-Chavez, M E AU - Icaza-Chavez ME AD - Christus Mugerza Faro del Mayab, Merida, Yucatan, Mexico. FAU - Martinez-Vazquez, S E AU - Martinez-Vazquez SE AD - Departamento de Gastroenterologia y Laboratorio de Motilidad Gastrointestinal, Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Mexico City, Mexico. FAU - Milke-Garcia, M P AU - Milke-Garcia MP AD - Departamento de Hemato Oncologia, Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Mexico City, Mexico. FAU - Montijo-Barrios, E AU - Montijo-Barrios E AD - Servicio de Gastroenterologia Pediatrica, Instituto Nacional de Pediatria, Mexico City, Mexico. FAU - Sanchez-Ramirez, C A AU - Sanchez-Ramirez CA AD - Facultad de Medicina, Universidad de Colima, Colima, Mexico. FAU - Toro-Monjaraz, E AU - Toro-Monjaraz E AD - Servicio de Gastroenterologia Pediatrica, Instituto Nacional de Pediatria, Mexico City, Mexico. FAU - Valdovinos-Diaz, M A AU - Valdovinos-Diaz MA AD - Hospital Medica Sur, Mexico City, Mexico. LA - eng PT - Journal Article PT - Practice Guideline DEP - 20260617 PL - Mexico TA - Rev Gastroenterol Mex (Engl Ed) JT - Revista de gastroenterologia de Mexico (English) JID - 101778603 RN - EC 3.2.1.108 (Lactase) RN - J2B2A4N98G (Lactose) SB - IM MH - Humans MH - *Lactose Intolerance/diagnosis/therapy MH - Mexico MH - Lactase/therapeutic use MH - Lactose OTO - NOTNLM OT - Deficient digestion OT - Digestion deficiente OT - Hipolactasia OT - Hypolactasia OT - Intolerance OT - Intolerancia OT - Lactasa OT - Lactase OT - Lactosa OT - Lactose OT - Mexico OT - Mexico COIS- Declaration of competing interest The authors declare that there is no conflict of interest. EDAT- 2026/06/18 00:32 MHDA- 2026/06/27 18:37 CRDT- 2026/06/17 21:57 PHST- 2025/10/17 00:00 [received] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/06/27 18:37 [medline] PHST- 2026/06/18 00:32 [pubmed] PHST- 2026/06/17 21:57 [entrez] AID - S2255-534X(26)00063-0 [pii] AID - 10.1016/j.rgmxen.2026.02.002 [doi] PST - ppublish SO - Rev Gastroenterol Mex (Engl Ed). 2026 Apr-Jun;91(2):231-253. doi: 10.1016/j.rgmxen.2026.02.002. Epub 2026 Jun 17. PMID- 42309663 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 17 TI - Measuring multisector nutrition and health intervention coverage using composite coverage analysis methods: a scoping review and methodological guidance. PG - e111298 LID - 10.1136/bmjopen-2025-111298 [doi] LID - e111298 AB - OBJECTIVES: Composite indices provide an opportunity to measure the reach of multisector strategies as countries progress towards Sustainable Development Goals and the achievement of nutrition, health and other sectoral targets. Composite measures allow for the measurement of nutrition and health intervention coverage across sectors and can be used to benchmark progress, track nutrition goals and assess inequities of multisector nutrition interventions. Of the many composite indices in use to measure health and nutrition intervention coverage and population status as a means of assessing progress in achieving health and nutrition targets, few have been previously documented in the nutrition and health literature, nor have these indicators been described in detail. This scoping review aimed to identify composite coverage indices that capture nutrition and health intervention coverage or status, summarise their estimation methodologies and validation approaches and evaluate their strengths and weaknesses. DESIGN: Scoping review conducted in accordance with the Joanna Briggs Institute Reviewer Manual following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) verification list. DATA SOURCES: PubMed, EMBASE, Scopus, Google Scholar and Global Health registries were searched from 1980 to 3 March 2026. ELIGIBILITY CRITERIA: We included studies of any design that described, used or developed a composite measurement of health or nutrition intervention coverage or status. DATA EXTRACTION AND SYNTHESIS: One reviewer screened the titles and abstracts and full text using Covidence and abstracted data from each article using Microsoft Excel using standardised methods. RESULTS: We retrieved and screened a total of 7120 records of which 154 articles were included. We identified a total of 56 unique indices (25 universal healthcare coverage; 14 reproductive, maternal, newborn, child health (RMNCH) coverage; 10 nutritional status, food security or nutrition intervention coverage; 6 health service coverage and 1 combined universal healthcare, health risk factors and nutrition coverage measure). We identified three major formula construction methodologies: normative (n=34), statistical (n=13) and participatory (n=10). Together, the indices employed six different aggregation methods: weighted linear mean (n=28), geometric mean (n=13), linear mean (n=9), random-effects meta-analysis (n=6), summation (n=2) and weighted geometric mean (n=1). More than one third of the indices identified have not been validated in the literature (n=21). CONCLUSIONS: Our review identified a significant gap in composite nutrition intervention coverage index availability, methodological frameworks for index design and index validation. There is a need for additional resources for guiding policy and programme actors to develop validated, fit for purpose composite nutrition-specific and nutrition-sensitive coverage indices. We propose that a framework be developed for stakeholders to guide composite index construction for multisectoral nutrition intervention coverage measurement. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Morrison, Taylor AU - Morrison T AUID- ORCID: 0009-0006-5346-5946 AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA tmorri45@alumni.jh.edu. FAU - Akseer, Nadia AU - Akseer N AUID- ORCID: 0000-0002-3802-7298 AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Heidkamp, Rebecca AU - Heidkamp R AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Maiga, Abdoulaye AU - Maiga A AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Tasic, Hana AU - Tasic H AUID- ORCID: 0009-0006-0589-3612 AD - Modern Scientist Global, St Catharines, Ontario, Canada. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260617 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Nutritional Status PMC - PMC13288883 OTO - NOTNLM OT - Health Equity OT - Health Services Accessibility OT - Health policy COIS- Competing interests: None declared. EDAT- 2026/06/18 00:32 MHDA- 2026/06/18 00:33 PMCR- 2026/06/17 CRDT- 2026/06/17 21:12 PHST- 2026/06/18 00:33 [medline] PHST- 2026/06/18 00:32 [pubmed] PHST- 2026/06/17 21:12 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - bmjopen-2025-111298 [pii] AID - 10.1136/bmjopen-2025-111298 [doi] PST - epublish SO - BMJ Open. 2026 Jun 17;16(6):e111298. doi: 10.1136/bmjopen-2025-111298. PMID- 42308182 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - A risk assessment indicator system for common diseases in children and adolescents. PG - e0351870 LID - 10.1371/journal.pone.0351870 [doi] LID - e0351870 AB - BACKGROUND: Adolescence is a critical stage for healthy development. Currently, common diseases such as myopia, obesity, dental caries, and spinal curvature abnormalities are highly prevalent among children and adolescents, with an obvious trend of younger onset. These diseases are caused by the complex interaction of multi-dimensional factors. However, existing interventions are mostly limited to individual diseases, lacking systematic prevention and control tools. Therefore, there is an urgent need to construct a scientific evaluation index system for health-influencing factors. OBJECTIVE: Targeting the four key common diseases emphasized in China's national health policies - myopia, obesity, dental caries, and spinal curvature abnormalities - among children and adolescents aged 7-19 years, this study constructed a multi-dimensional risk assessment indicator system to support evidence-based prevention and policy-making for this population. METHODS: Guided by the National Program of Action for Children's Development in China (2021-2030) and the "Healthy China 2030" Planning Outline, a three-level indicator framework was initially formulated through literature research and expert meetings. The Delphi expert consultation method was adopted for two rounds of screening and optimization of indicators. Experts scored each indicator on a scale of 1-5 in terms of importance, feasibility, and sensitivity, with indicators excluded if their mean score was < 3.5 and coefficient of variation >0.3. RESULTS: The effective return rate of the two-round Delphi is 100.0%, the mean expert familiarity coefficient (Cs) was 0.83, and the mean judgment coefficient (Ca) was 0.93, and the expert authoritative coefficient (Cr) value is 0.88. In the second round of consultation, the importance coordination coefficient is 0.284, the feasibility coordination coefficient is 0.185, and the sensitivity coordination coefficient is 0.314, all of which are statistically significant (P < 0.001). This indicator system consists of a total of 55 three-level indicators. CONCLUSION: Validated through two rounds of expert deliberation, the indicator system demonstrates sound scientific rigor. The preliminary development of a risk assessment indicator system for common diseases in children and adolescents can be used for the measurement of the level of factors affecting the health of common diseases in children and adolescents after its reliability and validity are verified in practical applications. CI - Copyright: (c) 2026 Shao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Shao, Yun AU - Shao Y AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. FAU - Hu, Bohan AU - Hu B AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. FAU - Lu, Yuting AU - Lu Y AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. FAU - Yu, Shuo AU - Yu S AD - NHC Key Laboratory of Health Technology Assessment (Fudan University), Shanghai, China. FAU - Liang, Ji AU - Liang J AUID- ORCID: 0000-0002-6844-5036 AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. LA - eng PT - Journal Article DEP - 20260617 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Child MH - Adolescent MH - Risk Assessment/methods MH - China/epidemiology MH - Female MH - Male MH - *Dental Caries/epidemiology/prevention & control MH - *Myopia/epidemiology/prevention & control MH - *Obesity/epidemiology/prevention & control MH - Young Adult PMC - PMC13274816 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/17 18:35 MHDA- 2026/06/17 18:36 PMCR- 2026/06/17 CRDT- 2026/06/17 13:33 PHST- 2025/11/08 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/17 18:36 [medline] PHST- 2026/06/17 18:35 [pubmed] PHST- 2026/06/17 13:33 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - PONE-D-25-58634 [pii] AID - 10.1371/journal.pone.0351870 [doi] PST - epublish SO - PLoS One. 2026 Jun 17;21(6):e0351870. doi: 10.1371/journal.pone.0351870. eCollection 2026. PMID- 42307362 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1474-7049 (Electronic) IS - 1474-7049 (Linking) VI - 24 IP - 2 DP - 2026 Apr-Jun TI - Buttocks or Breasts? Identifying Latent Subgroups in Male Preferences for Female Bodily Features. PG - 14747049261452897 LID - 10.1177/14747049261452897 [doi] LID - 14747049261452897 AB - Among the various physical traits that serve as secondary sexual characteristics, breasts and buttocks are visually conspicuous cues used in male mate evaluation because they signal youth, fertility, developmental stability, and nutritional status. Although these features have been extensively studied, less is known about the extent to which men differ in the relative importance they place on each trait. Latent Profile Analysis (LPA) identified distinct subgroups of Norwegian men (N = 395) based on how much importance they placed on breasts and buttocks in their evaluations of romantic partners. A four-class solution emerged, comprising Highly Body-Oriented (53%), Moderately Body-Oriented (20%), Buttocks-Oriented (18%), and Body-Unoriented (9%) subgroups. Predictors such as egalitarianism, materialism, and preferences for sexiness were, as expected, significantly associated with class membership, providing support for the validity of the typology. Notably, a consistent buttocks-oriented class emerged across all LPA solutions, whereas no distinct breasts-oriented group was found, as ratings of breasts persistently co-occurred with high ratings of buttocks, suggesting that breasts do not function as a primary preference in isolation. These findings reveal that buttocks may occupy a more central and stable role than breasts in male mate preferences, offering novel insights into the structure of physical attraction and heterogeneity in the male mating mind. FAU - Mehmetoglu, Mehmet AU - Mehmetoglu M AUID- ORCID: 0000-0002-6092-8551 AD - Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway. RINGGOLD: 8018 LA - eng PT - Journal Article DEP - 20260617 PL - England TA - Evol Psychol JT - Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior JID - 101219668 SB - IM MH - Humans MH - Male MH - Adult MH - *Breast MH - Young Adult MH - Buttocks MH - *Sexual Partners/psychology MH - *Choice Behavior/physiology MH - Norway MH - Female PMC - PMC13276209 OTO - NOTNLM OT - LPA OT - attractiveness OT - bodily OT - breasts OT - buttocks OT - male preference OT - physical COIS- Declaration of Conflicting InterestsThe author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/17 13:28 MHDA- 2026/06/17 13:29 PMCR- 2026/06/17 CRDT- 2026/06/17 09:23 PHST- 2026/06/17 13:29 [medline] PHST- 2026/06/17 13:28 [pubmed] PHST- 2026/06/17 09:23 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - 10.1177_14747049261452897 [pii] AID - 10.1177/14747049261452897 [doi] PST - ppublish SO - Evol Psychol. 2026 Apr-Jun;24(2):14747049261452897. doi: 10.1177/14747049261452897. Epub 2026 Jun 17. PMID- 42307272 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1807-3107 (Electronic) IS - 1806-8324 (Print) IS - 1806-8324 (Linking) VI - 40 DP - 2026 TI - Evaluation of the impacted upper canine and maxillary sinus dimensions using cone beam computed tomography. PG - e031 LID - S1806-83242026000108601 [pii] LID - 10.1590/1807-3107bor-2026.vol40.031 [doi] LID - e031 AB - This study aimed use cone beam computed tomography (CBCT) to compare the maxillary sinus volume and transverse dimensions between sides with and without palatally impacted maxillary canines. The CBCT records of 47 patients with unilateral palatally impacted canines (18 males, 29 females; mean age: 22.19 +/- 7.71 years) were included. The maxillary sinus volume was measured using semiautomatic segmentation, and transversal maxillary dimensions were assessed in the posterior region. Deviation of the nasal septum and alveolar pneumatization were also evaluated. Statistical analyses were performed using SPSS 25.0 with a significance level set at p < 0.05. As compared with the nonimpacted side, the maxillary and molar basal widths were significantly smaller and the septum deviation angle was greater on the impacted side (p < 0.05). A one-unit increase in the septal deviation angle increased the probability of impaction by 1.177 times. A negative correlation was detected between the maxillary sinus intensity and zygomatic width, molar basal width, and molar alveolar width (r = 0.431, 0.316, and 0.351, respectively). The incidence of pathological sinus findings did not differ significantly between sides (38.3% vs. 51.06%). Similarly, the rates of alveolar pneumatization were comparable (51.06% vs. 48.94%). The mean sinus volumes were 13,147.96 voxels on the impacted side and 13,194.38 voxels on the nonimpacted side, with no significant difference (p > 0.05). In conclusion, although palatally impacted maxillary canines are associated with narrower posterior maxillary transverse dimensions and increased septal deviation, they do not have a considerable effect on the maxillary sinus volume. These findings provide clinically relevant information for orthodontic diagnosis and surgical planning. FAU - Kurnaz, Merve AU - Kurnaz M AUID- ORCID: 0000-0003-2945-755X AD - Istanbul Kent University, School of Dentistry, Department of Orthodontics, Istanbul, Turkey. FAU - Kaygisiz, Emine AU - Kaygisiz E AUID- ORCID: 0000-0003-2087-7048 AD - Private Practice, Bursa, Turkey. FAU - Akay, Gulsun AU - Akay G AUID- ORCID: 0000-0002-1767-1383 AD - Gazi University, School of Dentistry, Department of Dentomaxillofacial Radiology, Ankara, Turkey. FAU - Gungor, Kahraman AU - Gungor K AUID- ORCID: 0000-0001-6336-4424 AD - Gazi University, School of Dentistry, Department of Dentomaxillofacial Radiology, Ankara, Turkey. FAU - Tortop, Tuba AU - Tortop T AUID- ORCID: 0000-0001-6153-2412 AD - Gazi University, School of Dentistry, Department of Orthodontics, Ankara, Turkey. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260612 PL - Brazil TA - Braz Oral Res JT - Brazilian oral research JID - 101307187 SB - IM MH - Humans MH - *Cone-Beam Computed Tomography/methods MH - Female MH - *Maxillary Sinus/diagnostic imaging/pathology MH - *Tooth, Impacted/diagnostic imaging/pathology MH - Reference Values MH - Male MH - *Cuspid/diagnostic imaging MH - Young Adult MH - Adult MH - Reproducibility of Results MH - Adolescent MH - Statistics, Nonparametric MH - Maxilla/diagnostic imaging MH - Organ Size PMC - PMC13263044 COIS- Declaration of interest: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript. EDAT- 2026/06/17 13:28 MHDA- 2026/06/17 13:29 PMCR- 2026/06/12 CRDT- 2026/06/17 09:22 PHST- 2025/08/28 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/06/17 13:29 [medline] PHST- 2026/06/17 13:28 [pubmed] PHST- 2026/06/17 09:22 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - S1806-83242026000108601 [pii] AID - 10.1590/1807-3107bor-2026.vol40.031 [doi] PST - epublish SO - Braz Oral Res. 2026 Jun 12;40:e031. doi: 10.1590/1807-3107bor-2026.vol40.031. eCollection 2026. PMID- 42307182 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1552-5783 (Electronic) IS - 0146-0404 (Print) IS - 0146-0404 (Linking) VI - 67 IP - 6 DP - 2026 Jun 1 TI - Early Prediction Model for Retinopathy of Prematurity Using Placental and Neonatal Risk Factors. PG - 35 LID - 10.1167/iovs.67.6.35 [doi] LID - 35 AB - PURPOSE: Existing prediction models for retinopathy of prematurity (ROP) primarily focus on screening reduction which occur 5 to 7 weeks after birth. We hypothesized that high-risk neonates could be identified much earlier if placental and early postnatal risk factors are incorporated, so that this high risk can be considered during neonatal treatment well before ROP screening begins. METHODS: We included 591 neonates born 1.0). Induction remission, TRM, complications, and treatment toxicity were compared across the three groups. Multivariate logistic regression analysis was performed to identify the associations between nutritional indicator changes and induction treatment outcomes. Receiver operating characteristic (ROC) curves were evaluated the predictive performance of weight Z-score decline for treatment toxicities and remission-phase mortality. RESULTS: Clinical data of a total of 62 pediatric patients (34 males, 28 females; mean age 7.3 +/- 3.6 years) were analyzed. Longitudinal monitoring revealed a consistent decline - then - recovery trend for weight Z-score, BMI Z-score, and serum albumin: all indicators decreased continuously from T0 to T2, followed by gradual recovery from T2 to T3. Weight Z-score and BMI Z-score reached their nadirs at T2, while serum albumin bottomed out at T1. Patients with severe weight Z-score decline showed significantly lower remission rates (56.3% vs. 88.5% in mild and 75.0% in moderate groups) and higher TRM (18.8%) and complication rates (87.5%). They also experienced more frequent gastrointestinal, hepatic, and infectious toxicities, and higher remission-phase mortality (12.5% vs. 0.0 and 5.0%). Multivariate analysis identified weight Z-score decline > 1.0 (OR = 4.826, 95%CI: 2.673-8.725) and serum albumin decline > 10 g/L (OR = 3.715, 95%CI: 2.012-6.857) as independent risk factors for poor outcomes. ROC analysis confirmed strong predictive value of weight Z-score decline for gastrointestinal toxicity (AUC = 0.823), hepatic toxicity (AUC = 0.812), infectious toxicity (AUC = 0.854), and remission-phase mortality (AUC = 0.881). CONCLUSION: The nutritional status of pediatric patients with newly diagnosed AML follows a distinct decline-then-recovery longitudinal pattern during induction chemotherapy. Greater decline and slower recovery are significantly associated with worse treatment outcomes. Weight Z-score decline serves as a robust predictor of subsequent toxicities and mortality, supporting its use alongside traditional static assessments. These findings provide an evidence-based rationale for initiating nutritional support by the time chemotherapy ends. CI - Copyright (c) 2026 Liu, Yan and Li. FAU - Liu, Chun-Lei AU - Liu CL AD - Department of Information Technology, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan, Shandong, China. FAU - Yan, Fan-Ling AU - Yan FL AD - Department of Pediatrics, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan, Shandong, China. FAU - Li, Xiao-Ling AU - Li XL AD - Department of Pediatrics, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan, Shandong, China. LA - eng PT - Journal Article DEP - 20260601 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13265345 OTO - NOTNLM OT - induction chemotherapy OT - longitudinal changes OT - nutritional status OT - pediatric acute myeloid leukemia OT - serum albumin OT - treatment outcomes OT - treatment toxicity OT - weight Z-score COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/17 06:31 MHDA- 2026/06/17 06:32 PMCR- 2026/06/01 CRDT- 2026/06/17 05:16 PHST- 2026/03/26 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/17 06:32 [medline] PHST- 2026/06/17 06:31 [pubmed] PHST- 2026/06/17 05:16 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.3389/fmed.2026.1839597 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Jun 1;13:1839597. doi: 10.3389/fmed.2026.1839597. eCollection 2026. PMID- 42305912 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260617 LR - 20260813 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 10 IP - 6 DP - 2026 Jun TI - Comparison of WHO and Centers for Disease Control and Prevention Growth References for Classifying Height and Weight Status in Young Children in the United States-Affiliated Pacific. PG - 107714 LID - 10.1016/j.cdnut.2026.107714 [doi] LID - 107714 AB - BACKGROUND: Multiple international growth reference systems exist for classifying child undernutrition and excess weight, yet different references yield systematically different prevalence estimates. This has important implications for surveillance in Pacific Islander populations, where both the Centers for Disease Control and Prevention (CDC) and WHO references are used across jurisdictions. OBJECTIVES: This study aimed to quantify classification discrepancies between WHO Growth Standards (ages 2-5 y), WHO Growth Reference (ages 6-8 y), and CDC Growth Charts (ages 2-8 y) in Pacific Islander children, and to assess implications for population health surveillance. METHODS: This secondary cross-sectional analysis used 2014 data from the Children's Healthy Living Program (n = 5499 children aged 2-8 y from 11 Pacific jurisdictions). Weight and height were measured by trained, standardized measurers. Children were classified by each reference system using SAS programs provided by the WHO and CDC. Agreement was evaluated using McNemar's test, kappa coefficients, and percent agreement. RESULTS: Height-for-age agreement was high across both age groups (>/=98.3%). BMI-for-age agreement differed substantially by age: poor for ages 2 to 5 y (kappa = 0.26; 85.5% agreement) and high for ages 6 to 8 y (kappa = 0.86; 97.9% agreement). For ages 2 to 5 y, the WHO classified 11 percentage points more children as overweight than the CDC. When identical percentile cutoffs were applied across reference datasets, prevalence differences narrowed substantially, indicating that most discrepancies result from differing classification criteria rather than reference population differences. CONCLUSIONS: Growth reference selection introduces systematic measurement bias into Pacific Islander child health surveillance. Surveillance systems should maintain reference consistency over time, explicitly report reference criteria, and consider dual reporting to enable valid temporal and geographic comparisons. Future research should evaluate which reference better predicts health outcomes in this population. CI - (c) 2026 The Author(s). FAU - Yamanaka, Ashley B AU - Yamanaka AB AD - Department of Human Nutrition, Food and Animal Sciences, College of Tropical Agriculture and Human Resilience, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Davis, James D AU - Davis JD AD - Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Wilkens, Lynne R AU - Wilkens LR AD - University of Hawai'i Cancer Center, Population Sciences in the Pacific, Honolulu, HI, United States. FAU - Hurwitz, Eric L AU - Hurwitz EL AD - Department of Public Health Sciences, Thomson School of Social Work & Public Health, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Fialkowski, Marie K AU - Fialkowski MK AD - University of Hawai'i Cancer Center, Population Sciences in the Pacific, Honolulu, HI, United States. FAU - Coleman, Patricia AU - Coleman P AD - Cooperative Research, Extension and Education Services, Northern Marianas College, Saipan, MP, United States. FAU - Deenik, Jonathan AU - Deenik J AD - Department of Tropical Plant and Soil Sciences, College of Tropical Agriculture and Human Resilience, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Fleming, Travis AU - Fleming T AD - Agriculture, Community and Natural Resources Division, American Samoa Community College, Pago Pago, AS, United States. FAU - Guerrero, Rachael Leon AU - Guerrero RL AD - College of Natural and Applied Sciences, University of Guam, Mangilao, GU, United States. FAU - Novotny, Rachel AU - Novotny R AD - Department of Human Nutrition, Food and Animal Sciences, College of Tropical Agriculture and Human Resilience, University of Hawai'i at Manoa, Honolulu, HI, United States. LA - eng PT - Journal Article DEP - 20260513 PL - United States TA - Curr Dev Nutr JT - Current developments in nutrition JID - 101717957 PMC - PMC13267550 OTO - NOTNLM OT - BMI-for-age OT - CDC OT - Pacific Islander OT - WHO OT - child growth OT - growth references OT - health disparities OT - obesity surveillance OT - pediatric anthropometry OT - stunting COIS- LRW is a member of the Current Developments of Nutrition Statistical Review Board. The authors have no conflicts of interest to declare. EDAT- 2026/06/17 06:32 MHDA- 2026/06/17 06:33 PMCR- 2026/05/13 CRDT- 2026/06/17 05:15 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/06/17 06:33 [medline] PHST- 2026/06/17 06:32 [pubmed] PHST- 2026/06/17 05:15 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - S2475-2991(26)00079-X [pii] AID - 107714 [pii] AID - 10.1016/j.cdnut.2026.107714 [doi] PST - epublish SO - Curr Dev Nutr. 2026 May 13;10(6):107714. doi: 10.1016/j.cdnut.2026.107714. eCollection 2026 Jun. PMID- 42305418 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260617 LR - 20260813 IS - 2590-1613 (Electronic) IS - 2590-1613 (Linking) VI - 30 DP - 2026 Jun TI - A sophisticated predictive framework for identifying obstructive sleep apnea syndrome in women with obesity during pregnancy. PG - 100465 LID - 10.1016/j.eurox.2026.100465 [doi] LID - 100465 AB - OBJECTIVE: To develop a risk prediction model of obstructive sleep apnea syndrome (OSAS) in obese pregnant women in order to facilitate early intervention. METHODS: We retrospectively analyzed polysomnography confirmed OSAS cases (n = 828) from Hefei Maternal and Child Health Hospital (Jan 1st,2023-Jan 1st,2025). Cases were classified according to the onset of the OSAS during pregnancy: non-occurrence (n = 526) and occurrence (n = 302). Predictive factors were determined using univariate logistic regression (P < 0.1), LASSO regularization (lambda = 0.007) and multivariate logistic regression. RESULTS: Five independent predictors were identified: tongue size, sleep position, neck circumference, Berlin Questionnaire score and Epworth Sleepiness Scale score. The model was found to have an area under the curve (AUC) of 0.811, good calibration (Hosmer-Lemeshow P = 0.275), low average absolute error (0.017), and net clinical benefit across risk thresholds (0.04-0.95). CONCLUSION: This five-variable model is a reliable predictor of the risk of OSAS in obese pregnant women and is useful for timely prenatal screening, risk stratification, and early management. CI - (c) 2026 The Authors. FAU - Jiang, Chen AU - Jiang C AD - Hefei Maternal and Child Health Care Hospital, No. 15, Yimin Street, Lu Yang District, Hefei City, Anhui Province, China. FAU - Zhou, Hong AU - Zhou H AD - Hefei Maternal and Child Health Care Hospital, No. 15, Yimin Street, Lu Yang District, Hefei City, Anhui Province, China. FAU - Yi, Jiao AU - Yi J AD - Hefei Maternal and Child Health Care Hospital, No. 15, Yimin Street, Lu Yang District, Hefei City, Anhui Province, China. FAU - Chen, Xianxia AU - Chen X AD - Hefei Maternal and Child Health Care Hospital, No. 15, Yimin Street, Lu Yang District, Hefei City, Anhui Province, China. LA - eng PT - Journal Article DEP - 20260601 PL - Netherlands TA - Eur J Obstet Gynecol Reprod Biol X JT - European journal of obstetrics & gynecology and reproductive biology: X JID - 101750520 PMC - PMC13265645 OTO - NOTNLM OT - Obesity in pregnancy OT - Obstructive sleep apnea syndrome OT - Prediction model OT - Regression analysis COIS- The authors have no competing interests to declare. EDAT- 2026/06/17 06:31 MHDA- 2026/06/17 06:32 PMCR- 2026/06/01 CRDT- 2026/06/17 05:07 PHST- 2026/04/06 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/17 06:32 [medline] PHST- 2026/06/17 06:31 [pubmed] PHST- 2026/06/17 05:07 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - S2590-1613(26)00022-0 [pii] AID - 100465 [pii] AID - 10.1016/j.eurox.2026.100465 [doi] PST - epublish SO - Eur J Obstet Gynecol Reprod Biol X. 2026 Jun 1;30:100465. doi: 10.1016/j.eurox.2026.100465. eCollection 2026 Jun. PMID- 42304432 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260813 IS - 1868-7083 (Electronic) IS - 1868-7075 (Print) IS - 1868-7075 (Linking) VI - 18 IP - 1 DP - 2026 Jun 16 TI - Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study. LID - 10.1186/s13148-026-02177-y [doi] LID - 118 AB - BACKGROUND: Blood-based DNA methylation has been linked to obesity and metabolic health, yet its relationship to adipose tissue function remains incompletely understood. This study aimed to investigate the epigenetic regulation of EIF5A (Eukaryotic translation initiation factor 5A-1) and TGIF1 (TGFB Induced Factor Homeobox 1) across blood and adipose tissue in obesity. METHODS: Candidate genes were identified using a multi-step gene selection approach integrating transcriptomic and epigenomic data from blood and adipose tissue samples obtained from children and adults across four diverse population- and disease-focused cohorts. Genes were prioritized based on differential DNA methylation and gene expression in obesity. Targeted bisulfite sequencing of EIF5A and TGIF1 was conducted in blood samples from adults across BMI-defined groups and from children prior to the development of obesity, to validate candidate loci and to examine associations with metabolic and adipocyte-related phenotypes. RESULTS: In adults from the Leipzig Obesity BioBank, blood DNA methylation (N = 150) of both EIF5A and TGIF1 was significantly increased in individuals with obesity. EIF5A mRNA expression (N = 1554) was significantly higher in omental-visceral adipose tissue compared with subcutaneous adipose tissue. Blood DNA methylation of EIF5A was associated with body mass index (BMI), glycated hemoglobin (HbA1c), and leukocyte counts, particularly among individuals with type 2 diabetes mellitus. In children, blood DNA methylation (N = 75) of EIF5A was associated with longitudinal HbA1c trajectories. For TGIF1, DNA methylation levels were increased in subcutaneous adipose tissue (N = 219) of children with obesity and correlated with fasting serum insulin concentrations. Across cohorts, TGIF1 regulation in both blood and adipose tissue showed consistent associations with adipocyte size. Notably, blood DNA methylation of TGIF1 in childhood was associated with body fat mass and HbA1c at later follow-up despite normal weight at baseline. CONCLUSION: EIF5A and TGIF1 DNA methylation represent cross-tissue epigenetic signatures linking blood-based DNA methylation to adipose tissue dysfunction, adipocyte hypertrophy, and early metabolic risk. These findings support the potential of blood DNA methylation markers to reflect adipose tissue health and metabolic outcomes across the lifespan. CI - (c) 2026. The Author(s). FAU - Ruf, Sophie AU - Ruf S AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. FAU - Hoffmann, Anne AU - Hoffmann A AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. FAU - Muller, Luise AU - Muller L AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. FAU - Landgraf, Kathrin AU - Landgraf K AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - Center for Pediatric Research, Leipzig University, Medical Faculty, University Hospital for Children and Adolescents, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. FAU - Vogel, Mandy AU - Vogel M AD - Center for Pediatric Research, Leipzig University, Medical Faculty, University Hospital for Children and Adolescents, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. AD - LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany. FAU - Jorsboe, Emil AU - Jorsboe E AD - Nuffield Department of Population Health, University of Oxford, Oxford, UK. AD - Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. AD - Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. AD - Center for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark. FAU - Kubitz, Phil AU - Kubitz P AD - Else Kroner-Fresenius-Center for Nutritional Medicine, Chair of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany. AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Dietrich, Arne AU - Dietrich A AD - Medical Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University of Leipzig, Leipzig, Germany. FAU - Ghosh, Adhideb AU - Ghosh A AD - Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. FAU - Noe, Falko AU - Noe F AD - Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. FAU - Wolfrum, Christian AU - Wolfrum C AD - Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. FAU - Claussnitzer, Melina AU - Claussnitzer M AD - Medical and Population Genetics Program & Broad Diabetes Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. AD - Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. AD - Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. FAU - Hauner, Hans AU - Hauner H AD - Else Kroner-Fresenius-Center for Nutritional Medicine, Chair of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany. AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Stumvoll, Michael AU - Stumvoll M AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany. FAU - Baber, Ronny AU - Baber R AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. AD - LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, Leipzig University, Leipzig, Germany. FAU - Bluher, Matthias AU - Bluher M AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. FAU - Korner, Antje AU - Korner A AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - Center for Pediatric Research, Leipzig University, Medical Faculty, University Hospital for Children and Adolescents, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. AD - LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany. FAU - Kovacs, Peter AU - Kovacs P AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. peter.kovacs@medizin.uni-leipzig.de. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. peter.kovacs@medizin.uni-leipzig.de. FAU - Keller, Maria AU - Keller M AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. maria.keller@helmholtz-munich.de. AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. maria.keller@helmholtz-munich.de. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. maria.keller@helmholtz-munich.de. LA - eng PT - Journal Article DEP - 20260616 PL - Germany TA - Clin Epigenetics JT - Clinical epigenetics JID - 101516977 RN - 0 (Homeodomain Proteins) RN - 0 (RNA-Binding Proteins) RN - 0 (Eukaryotic Translation Initiation Factor 5A) RN - 0 (Peptide Initiation Factors) RN - 0 (Repressor Proteins) RN - 0 (TGIF1 protein, human) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *DNA Methylation MH - Female MH - Male MH - *Homeodomain Proteins/genetics/blood MH - *Obesity/genetics/blood/metabolism MH - *RNA-Binding Proteins/genetics/blood MH - Eukaryotic Translation Initiation Factor 5A MH - *Peptide Initiation Factors/genetics/blood MH - *Repressor Proteins/genetics/blood MH - *Adipose Tissue/metabolism MH - Child MH - Cohort Studies MH - Adult MH - Epigenesis, Genetic MH - Body Mass Index MH - Middle Aged MH - Glycated Hemoglobin PMC - PMC13274240 OTO - NOTNLM OT - Adipose tissue OT - Blood OT - Childhood OT - DNA methylation OT - Epigenetics OT - Metabolism OT - Obesity OT - mRNA expression COIS- Declarations. Ethics approval and consent to participate: All participants or their parents gave written informed consent to participate in the studies. Procedures were approved by the University of Leipzig's ethics committee (LIFE Adult: Reg. No. 263-2009-14122009; LOBB: Reg. No. 159-12-21052012, 017ek-2012; LIFE Child: Reg. No. 264-10-19042010; Leipzig AT Childhood cohort: Reg. No. 265-08, 265-08-ff, NCT02208141) and conducted according to the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: MB received honoraria as a consultant and speaker from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Lilly, Novo Nordisk, Novartis, and Sanofi. All other authors declare no conflicts of interest. The funders had no role in the design of the study, the collection, analyses, or interpretation of data, in the decision to publish the results and the writing of the manuscript. EDAT- 2026/06/17 06:31 MHDA- 2026/06/18 06:32 PMCR- 2026/06/16 CRDT- 2026/06/17 00:13 PHST- 2026/02/27 00:00 [received] PHST- 2026/05/30 00:00 [accepted] PHST- 2026/06/18 06:32 [medline] PHST- 2026/06/17 06:31 [pubmed] PHST- 2026/06/17 00:13 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s13148-026-02177-y [pii] AID - 2177 [pii] AID - 10.1186/s13148-026-02177-y [doi] PST - epublish SO - Clin Epigenetics. 2026 Jun 16;18(1):118. doi: 10.1186/s13148-026-02177-y. PMID- 42304284 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 16 TI - Timing of primary maxillary tooth eruption in preterm compared to term infants: a retrospective longitudinal cohort study. LID - 10.1186/s12903-026-08851-0 [doi] LID - 1064 AB - BACKGROUND: Reported eruption times of primary teeth in term and preterm infants are largely based on detection of visible tooth structure at the gingival level by parents, paediatricians, or dentists. Furthermore, there is a lack of quantitative data on primary tooth eruption velocity in the literature. This study aimed to compare eruption timing, eruption velocity, and maximum crown length by modelling longitudinal crown eruption trajectories in term and preterm infants. METHODS: This retrospective longitudinal cohort study included 100 infants (51 preterm, 49 full-term) who were followed from the first weeks after birth with quarterly assessments over four years. A total of 626 serial maxillary plaster casts were obtained as part of a prospective clinical trial registered at clinicaltrials.gov (NCT00408746). The crown length of 1,885 primary teeth (central and lateral incisors, canines, first molars) was measured by one investigator on digitised casts using Blender software. Intrarater reliability was evaluated using intraclass correlation coefficients (ICC). Timing and velocity of eruption were estimated using a non-linear asymptotic growth model. RESULTS: Measurement reliability was excellent (ICC = 0.996). Comparing chronological age revealed that preterm infants had a mean eruption delay of 2.7 months compared to full-term infants, with a significant delay observed for canines (4.5 months). However, when corrected age (chronological age minus days born before 37 gestational weeks) was used, a mean delay of only 1.4 months with no significant differences was found. Model-derived eruption preceded commonly reported clinical eruption ages by 6.2 months in preterm and 7.7 months in full-term infants. The model-estimated maximum crown lengths were slightly smaller in preterm infants, though these differences were not statistically significant. Eruption velocity followed a non-linear pattern, with preterm infants showing a tendency towards higher eruption rates, suggesting catch-up growth. CONCLUSIONS: Based on our model, eruption timings reported in the literature likely correspond to clinical observations made when primary teeth have attained about half of their final crown height. Consequently, crown exposure through gingiva appears to occur on average about six months prior to clinically visible eruption. Although preterm infants show a delay in tooth eruption when assessed by their chronological age, this difference resolves after correction for prematurity. CI - (c) 2026. The Author(s). FAU - Hohoff, Ariane AU - Hohoff A AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Bosse, Linda AU - Bosse L AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Stamm, Thomas AU - Stamm T AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Schmid, Jonas Q AU - Schmid JQ AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Kanemeier, Moritz AU - Kanemeier M AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. kanemeier@uni-muenster.de. LA - eng SI - ClinicalTrials.gov/NCT00408746 PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260616 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - *Infant, Premature/physiology MH - Longitudinal Studies MH - Maxilla MH - Odontometry/methods MH - Retrospective Studies MH - Time Factors MH - Tooth Crown/anatomy & histology/growth & development MH - *Tooth Eruption/physiology MH - *Tooth, Deciduous/growth & development PMC - PMC13273975 OTO - NOTNLM OT - Preterm OT - Term OT - Tooth eruption COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the Medical Association Westphalia-Lippe (vdl/Ro, 13.04.1999). Informed consent to participate was obtained from the parents of infants involved in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/17 06:32 MHDA- 2026/06/17 06:33 PMCR- 2026/06/16 CRDT- 2026/06/17 00:06 PHST- 2026/03/27 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/17 06:33 [medline] PHST- 2026/06/17 06:32 [pubmed] PHST- 2026/06/17 00:06 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s12903-026-08851-0 [pii] AID - 8851 [pii] AID - 10.1186/s12903-026-08851-0 [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 16;26(1):1064. doi: 10.1186/s12903-026-08851-0. PMID- 42304271 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 16 TI - Base deficit and alactic base excess are promising early biological markers in pediatric sepsis. LID - 10.1186/s12887-026-07152-3 [doi] LID - 712 AB - BACKGROUND AND AIMS: The diagnosis and management of pediatric sepsis remain challenging and time-sensitive. Early biological markers that may identify patients at risk of progression to septic shock are needed. Base deficit (BD) has been associated with adverse outcomes in adult sepsis, while alactic base excess (ABE) reflects non-lactate metabolic acidosis. This study aimed to evaluate the performance of BD and ABE compared with lactate in pediatric sepsis and to assess their association with time to progression to septic shock. METHODS: This retrospective single-center cohort study included pediatric patients with sepsis between January 1, 2020, and September 1, 2024. Biomarkers were obtained at initial presentation prior to resuscitation. BD and ABE were categorized into normal, abnormal, and extremely abnormal groups based on distribution thresholds, while lactate was classified as normal (2.2 mmol/L). Diagnostic performance was assessed using ROC curve analysis. Time-to-event analyses were performed using Kaplan-Meier curves and multivariable Cox regression models adjusted for BMI, CRP, albumin, and Phoenix Sepsis Score. RESULTS: A total of 44 patients were included, of whom 30 (68.18%) developed septic shock. Lactate demonstrated lower discriminative performance (AUC 0.624, 95% CI 0.447-0.800) compared with BD (AUC 0.940, 95% CI 0.875-0.999) and ABE (AUC 0.905, 95% CI 0.813-0.997). Both BD and ABE showed higher sensitivity and specificity for identifying patients who progressed to septic shock. In adjusted analyses, abnormal and extremely abnormal ABE and BD were associated with an increased hazard of progression to septic shock. Median time to shock was shortest in patients with extremely abnormal BD and ABE (approximately 8-9 hours), followed by abnormal lactate (13 hours), abnormal ABE (17 hours), and abnormal BD (18 hours). CONCLUSIONS: BD and ABE were associated with progression to septic shock in pediatric sepsis and may provide clinically relevant information for early risk stratification. In this cohort, these markers demonstrated stronger discriminative performance than lactate and may reflect metabolic disturbances present earlier in the disease course. However, these findings should be interpreted cautiously given the retrospective design and require prospective multicenter validation before clinical implementation. CI - (c) 2026. The Author(s). FAU - Assaad, Amani AU - Assaad A AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Majdalani, Marianne AU - Majdalani M AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Ismail, Ali AU - Ismail A AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Moukhaiber, Jihane AU - Moukhaiber J AUID- ORCID: 0009-0008-4370-9809 AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. jm88@aub.edu.lb. LA - eng PT - Journal Article DEP - 20260616 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Biomarkers) RN - 33X04XA5AT (Lactic Acid) SB - IM MH - Humans MH - Biomarkers/blood MH - Retrospective Studies MH - Female MH - *Sepsis/blood/diagnosis/complications MH - Male MH - Child MH - *Lactic Acid/blood MH - Shock, Septic/diagnosis/blood/etiology MH - Child, Preschool MH - Disease Progression MH - Infant MH - ROC Curve MH - *Acid-Base Imbalance/diagnosis/blood PMC - PMC13445687 OTO - NOTNLM OT - Alactic base excess. OT - Base deficit OT - Lactate OT - Pediatrics OT - Sepsis OT - Septic shock COIS- Declarations. Ethical approval and consent to participate: The Institutional Review Board at AUBMC approved this study (BIO-2024-0043) on October 24, 2024, in accordance with the ethical principles of Belmont, 1979. Waiver for consent was approved by the Institutional Review Board as this is a retrospective observational study, and the research team are not involved in the clinical care of the collected patients. The waiver did not adversely affect the rights or welfare of the subjects, as their information was coded and handled with confidentiality, ensuring privacy and compliance with the ethical standards. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/17 06:32 MHDA- 2026/08/06 11:36 PMCR- 2026/06/16 CRDT- 2026/06/17 00:05 PHST- 2025/08/22 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/08/06 11:36 [medline] PHST- 2026/06/17 06:32 [pubmed] PHST- 2026/06/17 00:05 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s12887-026-07152-3 [pii] AID - 7152 [pii] AID - 10.1186/s12887-026-07152-3 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 16;26(1):712. doi: 10.1186/s12887-026-07152-3. PMID- 42304257 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260917 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 16 TI - Cross-cultural adaptation of the Spanish version of the Swimming with Independent Measure (SWIM). LID - 10.1186/s12887-026-07054-4 [doi] LID - 796 AB - BACKGROUND: Assessing aquatic functional abilities is essential for designing effective interventions for children and adolescents who undergo aquatic activities and/or therapy. However, there is a lack of validated instruments in Spanish addressing this need. The Swimming with Independent Measure (SWIM) assesses functional performance in aquatic environments across typical and atypical development. This study aimed to cross-culturally adapt and to evaluate content equivalence and face validity of the SWIM for use with Spanish-speaking professionals working in aquatic environments with children and adolescents. METHOD: A methodological study was conducted to perform the cross-cultural adaptation of the SWIM and evaluate its content equivalence and face validity. Cross-cultural adaptation followed Beaton's six-phase methodology: translation, synthesis, back-translation, expert committee review, and pilot testing. Two translators and two back-translators performed the linguistic adaptation. A multidisciplinary expert committee (n = 5) evaluated content equivalence, and 20 professionals meeting predefined eligibility criteria participated in pilot testing. Content equivalence was assessed during the expert committee review, while face validity was evaluated during pilot testing. RESULTS: After two expert committee rounds, 83.6% of items were classified as conceptually equivalent and 16.4% as similar. Content equivalence indices improved from Ave-CVI = 0.93 to 1.00 and UA-CVI = 0.73 to 1.00. Pilot testing with 20 professionals confirmed adequate comprehensibility, requiring minor revisions to a few items. The final Spanish version showed adequate content equivalence and satisfactory face validity. CONCLUSIONS: The Spanish version of the SWIM was cross-culturally adapted, demonstrating semantic, conceptual, idiomatic, and content equivalence with the original, and showed adequate face validity. CI - (c) 2026. The Author(s). FAU - Gavina-Barroso, Maria Isabel AU - Gavina-Barroso MI AUID- ORCID: 0000-0002-5685-7252 AD - Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Physiotherapy. Campus de Villaviciosa, Calle Tajo s/n, Villaviciosa de Odon, Madrid, 28670, Spain. FAU - Pacheco-da-Costa, Soraya AU - Pacheco-da-Costa S AUID- ORCID: 0000-0002-2226-3560 AD - Universidad de Alcala. Faculty of Medicine and Health Sciences. Department of Nursing and Physiotherapy. Neuromusculoskeletal Physical Therapy in Stages of Life Research Group (FINEMEV). Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Campus Universitario Externo, Autovia A2, km 33,200, Alcala de Henares, 28805, Spain. soraya.pacheco@uah.es. FAU - Rodriguez-Costa, Isabel AU - Rodriguez-Costa I AUID- ORCID: 0000-0002-6645-2187 AD - Universidad de Alcala. Faculty of Medicine and Health Sciences, Department of Nursing and Physical Therapy, Humanization in the Intervention of Physiotherapy for the Integral Attention to the People (HIPATIA) Research Group, Campus Universitario Externo, Autovia A2, km 33,200, Alcala de Henares, 28805, Spain. FAU - Garcia-Perez-de-Sevilla, Guillermo AU - Garcia-Perez-de-Sevilla G AUID- ORCID: 0000-0002-2689-1767 AD - Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Physiotherapy, Campus de Villaviciosa, Calle Tajo s/n, Villaviciosa de Odon, Madrid, 28670, Spain. FAU - Martinez-Caro, Leticia AU - Martinez-Caro L AUID- ORCID: 0000-0003-3486-4678 AD - Faculty of Health Sciences, UNIR., Avda. de La Paz, 137, Logrono, La Rioja, 26006, Spain. FAU - Sanchez-Sanchez, Beatriz AU - Sanchez-Sanchez B AUID- ORCID: 0000-0002-0223-9707 AD - Universidad de Alcala. Faculty of Medicine and Health Sciences. Department of Nursing and Physiotherapy, Physiotherapy in Women's Health (FPSM) Research Group, Campus Universitario Externo, Autovia A2, km 33,200, Alcala de Henares, 28805, Spain. AD - Ramon y Cajal Institute of Health Research - IRYCIS, Hospital Universitario Ramon y Cajal, Madrid, 28034, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20260616 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Swimming/physiology MH - *Cross-Cultural Comparison MH - Child MH - Reproducibility of Results MH - Adolescent MH - Translations MH - Spain MH - Male MH - Female MH - Pilot Projects PMC - PMC13520382 OTO - NOTNLM OT - Aquatic functional abilities OT - Aquatic therapy OT - Content equivalence OT - Cross-cultural adaptation OT - Face validity OT - Halliwick concept OT - Motor function in water COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Hospital Clinico San Carlos Ethics Committee, under the reference number CI 19/495-E. All procedures were conducted in accordance with established ethical standards and relevant guidelines. Competing interests: The authors declare no competing interests. EDAT- 2026/06/17 06:32 MHDA- 2026/08/27 05:35 PMCR- 2026/06/16 CRDT- 2026/06/17 00:05 PHST- 2025/07/30 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/06/17 06:32 [pubmed] PHST- 2026/06/17 00:05 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s12887-026-07054-4 [pii] AID - 7054 [pii] AID - 10.1186/s12887-026-07054-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 16;26(1):796. doi: 10.1186/s12887-026-07054-4. PMID- 42303482 OWN - NLM STAT- Publisher LR - 20260616 IS - 1532-9453 (Electronic) IS - 1055-8586 (Linking) DP - 2026 Jun 7 TI - Appendicitis as a model for pediatric surgical quality improvement and standardization. PG - 151663 LID - S1055-8586(26)00079-X [pii] LID - 10.1016/j.sempedsurg.2026.151663 [doi] AB - Appendicitis serves as a model for pathway-driven quality improvement (QI) in pediatric surgical care. The high case volume, predictable clinical trajectory, and measurable outcomes associated with acute appendicitis care facilitate identification of unwarranted practice variation and allow standardization to be feasible at scale. Starting in the mid-2010s, several QI initiatives transformed appendicitis management in children. This review highlights four QI efforts in pediatric appendicitis management including the shift of diagnostic imaging from routine computed tomography to ultrasound-first strategies, improved opioid stewardship, de-implementation of low-value practices such as routine total parenteral nutrition utilization, and generation of severity-guided clinical practice guidelines that decreased postoperative antibiotic durations. Across these domains, improvement followed a consistent progression through phases of documented variation, evidence consolidation, structured local implementation, guideline alignment, and eventually sustained monitoring of guideline-based practices. Continued progress will require ongoing development of pediatric-specific evidence, dissemination of evidence-based practices into broader practice settings, and focused efforts to ensure equitable implementation across populations. QI efforts for appendicitis serve as a transferable blueprint for value-based and safety-focused pediatric care, demonstrating that unwarranted variation can be reduced when evidence-based practices are embedded into structured clinical guidelines, process metrics and outcomes are measured transparently, and principles are reinforced through coordinated dissemination. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Borst, Johanna M AU - Borst JM AD - Division of Pediatric Surgery, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Raval, Mehul V AU - Raval MV AD - Division of Pediatric Surgery, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: mraval@luriechildrens.org. LA - eng PT - Journal Article DEP - 20260607 PL - United States TA - Semin Pediatr Surg JT - Seminars in pediatric surgery JID - 9216162 SB - IM OTO - NOTNLM OT - Antibiotic stewardship OT - Clinical practice guidelines OT - De-implementation OT - Pediatric appendicitis OT - Quality improvement OT - Standardized care COIS- Declaration of competing interest The authors report no conflicts of interest relevant to this article. EDAT- 2026/06/17 00:36 MHDA- 2026/06/17 00:36 CRDT- 2026/06/16 21:56 PHST- 2026/04/16 00:00 [received] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/06/17 00:36 [medline] PHST- 2026/06/17 00:36 [pubmed] PHST- 2026/06/16 21:56 [entrez] AID - S1055-8586(26)00079-X [pii] AID - 10.1016/j.sempedsurg.2026.151663 [doi] PST - aheadofprint SO - Semin Pediatr Surg. 2026 Jun 7:151663. doi: 10.1016/j.sempedsurg.2026.151663. PMID- 42303130 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260928 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 75 DP - 2026 Oct TI - Chyme reinfusion for management of double enterostomies and entero-atmospheric fistulae in adult patients: An updated systematic review. PG - 103399 LID - S2405-4577(26)00496-1 [pii] LID - 10.1016/j.clnesp.2026.103399 [doi] AB - BACKGROUND & AIMS: Management of intestinal failure is costly, complex and associated with significant morbidity. Emerging evidence suggests that chyme reinfusion therapy is a safe, effective and promising technique in patients with intestinal failure. This review aims to assess the safety and benefits of chyme reinfusion therapy among patients with double enterostomy or enteroatmospheric fistulae. METHODS: A systematic review of the literature was conducted on 23rd March 2025. MEDLINE, EMBASE, CINAHL, Cochrane Library, and Scopus databases were searched for literature published between January 2019 and March 2025. Conference proceedings from 21 intestinal failure, gastroenterology, and gastrointestinal surgical conferences were searched on 7th April 2025. Articles eligible for inclusion reported on clinical or economic outcomes for CRT (using any method) performed in adult patients with an enterostomy or intestinal fistula, irrespective of the study design. Exclusion criteria were studies of neonatal or paediatric patients, animal studies, letters, editorials, and books. Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklists. A narrative synthesis was performed. RESULTS: Twenty-six reports from 23 studies provided outcomes for 620 patients undergoing CRT. Eighty per cent of patients (8 studies) ceased parenteral nutrition following CRT, with significant reductions in a further 5 studies. There were improvements in weight or BMI in 11 studies, reduction in intestinal output in 7 studies, correction or improvement in liver function test derangement in 8 studies, and improved markers of enterocyte function in 4 studies. Despite some technical issues and common early gastrointestinal side effects, CRT was well tolerated with few major adverse events. CONCLUSIONS: This updated systematic review supports current evidence that CRT is safe and beneficial for patients with IF secondary to DES or EAF, particularly due to reduction of parenteral nutrition and stomal losses, correction of biochemical LFT derangement, and improved enterocyte function. Built-for-purpose devices appear to improve usability, but appropriate patient selection remains essential to ensure benefit and mitigation of harm with these devices. We hope this review will provide a contemporary overview of the evidence and the knowledge gaps regarding chyme reinfusion therapy. REGISTRATION: PROSPERO (ID: CRD42023389095). CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Keane, Celia AU - Keane C AD - Department of Surgery, The University of Auckland, Auckland, Aotearoa, New Zealand; The Insides Company, Aotearoa, New Zealand; Department of Surgery, Te Tai Tokerau, Te Whatu Ora, Aotearoa, New Zealand. Electronic address: celia.keane@tewhatuora.govt.nz. FAU - Wells, Cameron AU - Wells C AD - Department of Surgery, The University of Auckland, Auckland, Aotearoa, New Zealand. FAU - Bhat, Sameer AU - Bhat S AD - Department of Surgery, The University of Auckland, Auckland, Aotearoa, New Zealand; Department of Surgery, Wellington Regional Hospital, Te Whatu Ora - Capital, Coast, and Hutt Valley, Wellington, Aotearoa, New Zealand. FAU - Liu, Chen AU - Liu C AD - Department of Surgery, The University of Auckland, Auckland, Aotearoa, New Zealand; Department of Colorectal Surgery, Concord Repatriation General Hospital, Sydney Local Health District, NSW, Australia. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260616 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Adult MH - Female MH - Humans MH - *Enterostomy/methods MH - *Intestinal Failure/therapy MH - *Intestinal Fistula/therapy MH - Treatment Outcome OTO - NOTNLM OT - Fistula OT - Ileostomy OT - Intestinal failure OT - chyme OT - re-feeding COIS- Declaration of interests CK is a medical advisor for the Insides Company. CL used the Insides System in a RCT of CRT during his doctoral studies. The remaining authors have no relevant conflicts to declare. EDAT- 2026/06/17 00:36 MHDA- 2026/09/23 05:35 CRDT- 2026/06/16 19:36 PHST- 2026/02/01 00:00 [received] PHST- 2026/05/21 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/09/23 05:35 [medline] PHST- 2026/06/17 00:36 [pubmed] PHST- 2026/06/16 19:36 [entrez] AID - S2405-4577(26)00496-1 [pii] AID - 10.1016/j.clnesp.2026.103399 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Oct;75:103399. doi: 10.1016/j.clnesp.2026.103399. Epub 2026 Jun 16. PMID- 42302825 OWN - NLM STAT- Publisher LR - 20260616 IS - 1098-8785 (Electronic) IS - 0735-1631 (Linking) DP - 2026 Jun 16 TI - Association between Gestational Weight Gain and Neonatal Hypoxic and Traumatic Events: Results from a Large Retrospective Cohort. LID - 10.1055/a-2884-9010 [doi] AB - OBJECTIVE: Most of the published studies focus on the relationship between gestational weight gain (GWG) and maternal outcomes, and less so on the neonatal outcomes. Furthermore, optimal GWG ranges defined by the Institute of Medicine were challenged by research showing the benefits of smaller GWG for overweight and obese mothers. Therefore, we intended to assess whether there is an association between GWG and hypoxic or traumatic events in the neonate, especially among overweight and obese mothers, as we sought the best methodological approach to study GWG. STUDY DESIGN: We used the Consortium on Safe Labor data, a retrospective cohort study collecting pregnancy data from 2002 to 2008 in 12 U.S. centers. The association between GWG and neonatal morbidity was estimated in singleton gestations >/= 37 weeks' gestation using binomial logistic regression models. GWG was analyzed as a continuous linear, continuous quadratic, categorical, and binary variable. The Hosmer-Lemeshow test (HL) assessed calibration of the models, the Brier score evaluated calibration and the overall model performance, whereas the area under the receiver-operating characteristic curve (AUC) measured discrimination. RESULTS: Among 104,599 mothers 24,609 (23.5%) were overweight and 19,324 (18.5%) obese; 7,974 (7.6%) infants experienced hypoxic, whereas 2,031 (1.9%) developed traumatic morbidity. The risk of infant morbidity increased with GWG, with thresholds of 6 to 23 kg for ischemic events, and 4 to 21 kg for traumatic events (p < 0.05). Multivariable models showed adequate calibration for traumatic, and for hypoxic events, the latter only when GWG was analyzed as a quadratic or categorical variable (HL tests, p > 0.01). In contrast, discrimination was poor for all models (AUCs /=IV), bone marrow involvement, elevated serum lactate dehydrogenase (LDH) level (>500 IU/L), sTMTV, sDmax, and the PET-based risk group were significant prognostic factors for event-free survival ( P < 0.05). For overall survival, significant factors included LDH level, sTMTV, sDmax, and the PET-based risk group ( P < 0.05). The PET-based risk stratification was also reflected in survival outcomes. CONCLUSIONS: sTMTV and sDmax derived from FDG PET/CT are significant prognostic biomarkers in pediatric NHL. Their combination enables effective stratification of pediatric patients with NHL into distinct risk groups and may inform future risk-adapted management strategies, potentially improving survival in this population. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Hwang, Sang Hyun AU - Hwang SH AUID- ORCID: 0000-0002-8130-6671 AD - Department of Nuclear Medicine, Severance Hospital. FAU - Ahn, Won Kee AU - Ahn WK AUID- ORCID: 0000-0003-3668-7396 AD - Department of Pediatrics, Division of Pediatric Hematology and Oncology, Yonsei University College of Medicine. AD - Department of Pediatric Hemato-Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea. FAU - Cho, Hojin AU - Cho H AD - Department of Nuclear Medicine, Severance Hospital. FAU - Lee, Hae Won AU - Lee HW AUID- ORCID: 0000-0002-6088-7470 AD - Department of Pediatrics, Division of Pediatric Hematology and Oncology, Yonsei University College of Medicine. AD - Department of Pediatric Hemato-Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea. FAU - Han, Jung Woo AU - Han JW AUID- ORCID: 0000-0001-8936-1205 AD - Department of Pediatrics, Division of Pediatric Hematology and Oncology, Yonsei University College of Medicine. AD - Department of Pediatric Hemato-Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea. FAU - Hahn, Seung Min AU - Hahn SM AUID- ORCID: 0000-0001-9832-6380 AD - Department of Pediatrics, Division of Pediatric Hematology and Oncology, Yonsei University College of Medicine. AD - Department of Pediatric Hemato-Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea. FAU - Kang, Won Jun AU - Kang WJ AD - Department of Nuclear Medicine, Severance Hospital. LA - eng PT - Journal Article DEP - 20260617 PL - United States TA - Clin Nucl Med JT - Clinical nuclear medicine JID - 7611109 RN - 0Z5B2CJX4D (Fluorodeoxyglucose F18) SB - IM MH - Humans MH - *Positron Emission Tomography Computed Tomography MH - *Fluorodeoxyglucose F18 MH - Female MH - *Lymphoma, Non-Hodgkin/diagnostic imaging/pathology/metabolism MH - Child MH - Male MH - Child, Preschool MH - Infant MH - *Tumor Burden MH - Adolescent MH - Retrospective Studies MH - Risk Assessment MH - Prognosis OTO - NOTNLM OT - FDG OT - PET-CT OT - children OT - non-Hodgkin lymphoma OT - tumor burden OT - tumor dissemination COIS- Conflicts of interest and sources of funding: none declared. EDAT- 2026/06/17 00:36 MHDA- 2026/07/08 01:11 CRDT- 2026/06/16 18:13 PHST- 2026/03/09 00:00 [received] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/07/08 01:11 [medline] PHST- 2026/06/17 00:36 [pubmed] PHST- 2026/06/16 18:13 [entrez] AID - 00003072-990000000-02336 [pii] AID - 10.1097/RLU.0000000000006556 [doi] PST - ppublish SO - Clin Nucl Med. 2026 Aug 1;51(8):e577-e582. doi: 10.1097/RLU.0000000000006556. Epub 2026 Jun 17. PMID- 42302708 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1525-1438 (Electronic) IS - 1048-891X (Linking) VI - 36 IP - 7 DP - 2026 Jul TI - Menopausal hormone therapy prescription and ovary-sparing surgery in women with pre-menopausal endometrial cancer: a Swedish PremEnCa study. PG - 104776 LID - S1048-891X(26)00307-5 [pii] LID - 10.1016/j.ijgc.2026.104776 [doi] AB - OBJECTIVE: The use of ovary-sparing surgery and menopausal hormone therapy after endometrial cancer is controversial, requiring a balance between a presumed increased risk of recurrence and the well-known adverse effects of premature menopause. Studies on this topic, specifically in pre-menopausal women, are scarce and heterogeneous. This nationwide, population-based, retrospectively conducted cohort study aimed to describe the use of ovary-sparing surgery and post-treatment menopausal hormone therapy in pre-menopausal women with endometrial cancer and to analyze related factors. METHODS: The study population comprised women aged 0.05). Gender-specific analysis revealed significant differences between the control group and all three AIS subgroups in women (p < 0.05), while in males, significant differences were seen solely between the mild and moderate AIS groups and the control group (p < 0.05). CONCLUSION: The results of this study suggest elevated 2D:4D ratios may signify reduced androgen or increased estrogen exposure during the prenatal phase and are correlated with AIS. The 2D:4D ratio may function as an economical, non-invasive biomarker for AIS. Subsequent research should investigate the viability of this biomarker for clinical screening and therapeutic strategizing. This work is among the first in the literature to assess the 2D:4D ratio in relation to AIS, indicating its potential to significantly enhance the existing body of research. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Isik, Mustafa AU - Isik M AD - Department of Orthopedics and Traumatology, School of Medicine, Gaziantep University, Gaziantep, Turkey. FAU - Unat, Beytullah AU - Unat B AD - Department of Orthopedics and Traumatology, School of Medicine, Gaziantep Islam Science and Technology University, Gaziantep, Turkey. FAU - Gonder, Nevzat AU - Gonder N AD - Department of Orthopedics and Traumatology, School of Medicine, Gaziantep University, Gaziantep, Turkey. FAU - Kaya, Onur AU - Kaya O AD - Department of Orthopaedics and Traumatology, Gaziantep City Hospital, Gaziantep, Turkey. FAU - Ozturk, Cansu AU - Ozturk C AD - Department of Anatomy, School of Medicine, Gaziantep Islam Science and Technology University, Gaziantep, Turkey; Gaziantep University Graduate School of Health Sciences, Gaziantep, Turkey. FAU - Tasdemir, Rabia AU - Tasdemir R AD - Department of Anatomy, School of Medicine, Gaziantep Islam Science and Technology University, Gaziantep, Turkey. Electronic address: rabia.tasdemir@gibtu.edu.tr. LA - eng PT - Journal Article DEP - 20260610 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging/epidemiology MH - Adolescent MH - Female MH - Child MH - Male MH - *Fingers/diagnostic imaging/anatomy & histology MH - *Digit Ratios MH - Case-Control Studies MH - Retrospective Studies MH - Cross-Sectional Studies OTO - NOTNLM OT - 2D:4D ratio OT - Adolescent idiopathic scoliosis OT - Biomarker OT - Cobb angle OT - Prenatal hormones COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/17 00:36 MHDA- 2026/09/04 23:36 CRDT- 2026/06/16 18:07 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/06/17 00:36 [pubmed] PHST- 2026/06/16 18:07 [entrez] AID - S0378-3782(26)00133-7 [pii] AID - 10.1016/j.earlhumdev.2026.106608 [doi] PST - ppublish SO - Early Hum Dev. 2026 Nov;222:106608. doi: 10.1016/j.earlhumdev.2026.106608. Epub 2026 Jun 10. PMID- 42302445 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Adaptation of the Mindful Eating Scale to Turkish for the adolescent population: A validity and reliability study. PG - 184-192 LID - S0882-5963(26)00275-7 [pii] LID - 10.1016/j.pedn.2026.06.010 [doi] AB - PURPOSE: This study aimed to examine the psychometric properties of the Turkish version of the Mindful Eating Scale among adolescents. METHOD: The research was conducted methodologically with a sample of 800 adolescents. Data were collected using a Sociodemographic Information Form and the Mindful Eating Scale. Statistical analyses included language, content, and construct validity (Confirmatory Factor Analysis), as well as internal consistency and test-retest reliability. RESULTS: The mean age of the adolescents participating in the study was 15.72 +/- 0.87. the final scale consisted of 24 item and six sub-dimensions. Of the adolescents, 94.3% did not have any nutrition-related diseases, 58.1% had knowledge about mindful eating, and 83.3% had not received nutrition education. Factor loadings of the scale were found to range between 0.317 and 0.846. All items significantly contributed to their respective factors. Fit indices were found to be chi2/df = 3.489, GFI = 0.91, IFI = 0.90, CFI = 0.90, RMSEA = 0.05, and SRMR = 0.06. These values indicate that the scale's fit is acceptable and at a good level. Cronbach's alpha coefficient of the scale was 0.78, indicating good internal consistency. CONCLUSION: The Mindful Eating Scale, presented in its Turkish version, is a valid and reliable tool. It can be effectively used by school counselors, dietitians, pediatric nurses and healthcare providers and researchers to assess nutritional behaviors in adolescent populations and develop mindful awareness-based interventions. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Arslan, Nurten AU - Arslan N AD - Department of Pediatric Nursing, Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. Electronic address: nurten.arslan@beun.edu.tr. FAU - Kurtuncu, Meltem AU - Kurtuncu M AD - Department of Pediatric Nursing, Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. FAU - Celik, Melike Yavas AU - Celik MY AD - Department of Midwifery, Faculty of Health Sciences, Gazianetep University, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20260616 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Adolescent MH - Turkey MH - Reproducibility of Results MH - Female MH - Psychometrics MH - Male MH - Surveys and Questionnaires MH - *Mindfulness MH - *Feeding Behavior/psychology MH - *Adolescent Behavior/psychology OTO - NOTNLM OT - Adolescent OT - Adolescent nutrition OT - Awareness OT - Mindful eating OT - Psychometric properties OT - Validity and reliability COIS- Declaration of competing interest There is no conflict of interest between the authors. EDAT- 2026/06/17 00:36 MHDA- 2026/09/07 23:34 CRDT- 2026/06/16 18:04 PHST- 2026/01/07 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/06/17 00:36 [pubmed] PHST- 2026/06/16 18:04 [entrez] AID - S0882-5963(26)00275-7 [pii] AID - 10.1016/j.pedn.2026.06.010 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:184-192. doi: 10.1016/j.pedn.2026.06.010. Epub 2026 Jun 16. PMID- 42301711 OWN - NLM STAT- MEDLINE DCOM- 20260616 LR - 20260827 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 6 DP - 2026 Jun 1 TI - Sociodemographic, Health Care, and Clinical Factors Associated With Metabolic Bariatric Surgery Uptake Among US Adults With Obesity. PG - e2618686 LID - 10.1001/jamanetworkopen.2026.18686 [doi] LID - e2618686 AB - IMPORTANCE: Metabolic bariatric surgery (MBS) is a highly effective but underused treatment for obesity. Greater understanding of diagnosis and referral pathways are needed to help inform appropriate treatment options for obesity. OBJECTIVE: To examine factors associated with uptake of MBS among individuals with incident obesity diagnosis. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used insurance claims data from the Merative MarketScan Commercial Claims and Encounters Database to identify a cohort of individuals aged 18 to 64 years with an incident obesity diagnosis (index) in inpatient and outpatient settings between January 1, 2018, and December 31, 2022, as well as MBS uptake within 12 months of index to December 31, 2023. EXPOSURES: Diagnoses classified using Agency for Healthcare Research and Quality Clinical Classifications Software Refined and therapeutic classes (Red Book) of drugs taken within the 12-month period prior to index date, as well as sociodemographic and health care factors determined at the index date. MAIN OUTCOMES AND MEASURES: Factors associated with MBS uptake were examined using machine learning methods and multivariable logistic regression. Exclusion criteria included pregnancy-related visits; missing International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, body mass index (BMI) Z-code; or prior MBS. The top 25 factors identified by a random forest model were ranked by Shapley Additive Explanation (SHAP) values, and odds ratios (ORs) were estimated for each top factor in a multivariable logistic regression model. RESULTS: In this study of 109 849 individuals (mean [SD] age, 41.4 [11.8] years; 63 992 women [58.3%]) with an initial obesity diagnosis, 3268 (3.0%) received MBS within 12 months of index. The area under the receiver operating characteristic curve score was 0.88 (95% CI, 0.87-0.90). The top factors identified by the random forest model included surgeon (not elsewhere classified [NEC]) as provider (which includes medical institutions and organizations as well as health care professionals) (mean SHAP value, 0.00918 [95% CI, 0.00893-0.00945]), BMI category (mean SHAP value, 0.00501 [95% CI, 0.00499-0.00503]), family practice as provider (mean SHAP value, 0.00372 [95% CI, 0.00370-0.00374]), and female sex (mean SHAP value, 0.00370 [95% CI, 0.00368-0.00371]). Surgeon (NEC) as provider had the largest OR (18.97 [95% CI, 17.11-21.02]), followed by other provider types (orthopedic surgeon: OR, 5.33 [95% CI, 4.54-6.24]; dietitian: OR, 2.51 [95% CI, 1.97-3.20]). Several medication (antidiabetic agents, miscellaneous: OR, 1.42 [95% CI, 1.25-1.62]; psychotherapeutics, antidepressants: OR, 1.13 [95% CI, 1.01-1.25]), diagnostic (depressive disorders: OR, 1.16 [95% CI, 1.02-1.33]), and sociodemographic variables (female sex: OR, 2.45 [95% CI, 2.22-2.71]) were also significantly associated with MBS. There was a significant decrease in MBS uptake for individuals with incident obesity diagnosis in more recent year-quarters from 2019 through 2022. CONCLUSIONS AND RELEVANCE: In this cohort study of individuals with an initial obesity diagnosis, uptake of MBS was patterned by demographic, clinical, and health care factors. This finding suggests substantial opportunity to improve access to MBS through targeted policies and interventions. FAU - Raquib, Rafeya V AU - Raquib RV AD - Department of Global Health, Boston University School of Public Health, Boston, Massachusetts. FAU - Tokarski, Allison AU - Tokarski A AD - Johnson & Johnson MedTech, Cincinnati, Ohio. FAU - Doshi, Ishita AU - Doshi I AD - Johnson & Johnson MedTech, Raritan, New Jersey. FAU - Afolabi, Mosadoluwa AU - Afolabi M AD - Johnson & Johnson MedTech, New Brunswick, New Jersey. FAU - Tomaszewski, Jorg AU - Tomaszewski J AD - Johnson & Johnson MedTech, Raritan, New Jersey. FAU - Johnston, Stephen AU - Johnston S AD - Johnson & Johnson MedTech, New Brunswick, New Jersey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260601 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - *Bariatric Surgery/statistics & numerical data MH - Female MH - Adult MH - *Obesity/surgery/epidemiology MH - United States/epidemiology MH - Middle Aged MH - Male MH - Adolescent MH - Young Adult MH - Cohort Studies MH - Socioeconomic Factors PMC - PMC13273493 COIS- Conflict of Interest Disclosures: Ms Tokarski reported being an employee of Johnson & Johnson Inc during the conduct of the study. Ms Doshi reported being an employee and stockholder of Johnson & Johnson Inc. Ms Afolabi reported being an employee of Johnson & Johnson Inc during the conduct of the study. Dr Tomaszewski reported being an employee and shareholder of Johnson & Johnson MedTech Surgery. Dr Johnston reported being an employee of Johnson & Johnson during the conduct of the study. No other disclosures were reported. EDAT- 2026/06/16 13:32 MHDA- 2026/06/16 13:33 PMCR- 2026/06/16 CRDT- 2026/06/16 11:33 PHST- 2026/06/16 13:33 [medline] PHST- 2026/06/16 13:32 [pubmed] PHST- 2026/06/16 11:33 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 2850418 [pii] AID - zoi260521 [pii] AID - 10.1001/jamanetworkopen.2026.18686 [doi] PST - epublish SO - JAMA Netw Open. 2026 Jun 1;9(6):e2618686. doi: 10.1001/jamanetworkopen.2026.18686. PMID- 42298961 OWN - NLM STAT- Publisher LR - 20260708 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Jun 16 TI - Diet quality and risk of using medication for hypertension up to 11 years after delivery: testing the predictive validity of a proposed revision of the Nutri-Score and the current Nutri-Score in the NewTools project. PG - 1-9 LID - 10.1017/S0007114526107697 [doi] AB - The aim of this study was to investigate the predictive validity of a proposed revision of the Nutri-Score and the current Nutri-Score by investigating associations between the diet quality scores measured in mid-pregnancy and the risk of dispensed prescription of medications for hypertension up to 11 years following delivery and blood pressure mid-pregnancy. The study population (n 70 730) were participants in the Norwegian Mother, Father and Child Cohort Study. Food intake was assessed in mid-pregnancy using a validated FFQ. Nutritional scores for each food item were calculated based on content of energy, sugars, saturated fat, salt, fibre, protein, fruit, vegetables and legumes. Diet quality scores were derived using energy-weighted means of nutritional scores. Anti-hypertensive medications were registered in the national prescription database. We estimated hazard ratios (HRs) with 95 % CIs using Cox regression models. During a mean follow-up of 6 years, 4736 (6.7 %) women were dispensed prescription for medications for hypertension. There was a non-linear association between diet quality and hypertension medication. Compared with the median diet quality score, poorer diet quality (90th percentile of the score) was associated with higher risk of medications for hypertension (HR = 1.08, 95 % CI 1.02, 1.14) and cross-sectional high diastolic blood pressure (OR = 1.18, 95 % CI 1.03, 1.32). Both diet quality scores yielded similar results overall. Poorer diet quality during pregnancy, assessed with a proposed version, and the current Nutri-Score, was associated with a higher risk of medications for hypertension, indicating its usefulness as a valuable tool for guiding consumers and improving public health. FAU - Amberntsson, Anna AU - Amberntsson A AUID- ORCID: 0000-0003-3510-9789 AD - Department of Food Safety, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. AD - Centre for Sustainable Diets, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. FAU - Abel, Marianne Hope AU - Abel MH AD - Centre for Sustainable Diets, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. AD - Centre for Evaluation of Public Health Measures, Norwegian Institute of Public Health, Norway. AD - Department of Physical Health and Ageing, Norwegian Institute of Public Health, Norway. FAU - Paulsen, Mari Mohn AU - Paulsen MM AD - Department of Food Safety, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. AD - Centre for Sustainable Diets, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. FAU - Andersen, Lene Frost AU - Andersen LF AD - Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway. FAU - Oyen, Jannike AU - Oyen J AD - Department of Seafood and Nutrition, Institute of Marine Research, Norway. AD - Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Norway. FAU - Rosendahl-Riise, Hanne AU - Rosendahl-Riise H AUID- ORCID: 0000-0002-1497-416X AD - Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Norway. FAU - Brantsaeter, Anne Lise AU - Brantsaeter AL AUID- ORCID: 0000-0001-6315-7134 AD - Department of Food Safety, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. AD - Centre for Sustainable Diets, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. LA - eng PT - Journal Article DEP - 20260616 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Food rating system OT - Front-of-pack nutrition label OT - MoBa OT - Nutri-Score OT - Nutrient profiling OT - Nutritional quality OT - Predictive validity EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:35 CRDT- 2026/06/16 02:43 PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 06:35 [medline] PHST- 2026/06/16 02:43 [entrez] AID - S0007114526107697 [pii] AID - 10.1017/S0007114526107697 [doi] PST - aheadofprint SO - Br J Nutr. 2026 Jun 16:1-9. doi: 10.1017/S0007114526107697. PMID- 42298737 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260823 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Jun 15 TI - GAIN: a multicenter pilot protocol for early initiation of enteral feeds in neonates with simple gastroschisis. LID - 10.1186/s40814-026-01860-4 [doi] LID - 123 AB - BACKGROUND: Gastroschisis is a congenital abdominal wall defect characterized by severe gut dysmotility. These neonates often face lengthy hospital stays, prolonged parenteral nutrition dependence, and complications such as growth faltering, sepsis, and intestinal failure. Feeding practices for neonates with gastroschisis vary and emphasize extended bowel rest and delayed feeding initiation. Usual practices in determining timing to start feeds include awaiting return of bowel function which typically consists of low Replogle output volume, color changing from bilious to clear and/or passing stool. However, emerging studies suggest that early initiation of feeds through standardized protocols may improve outcomes. The Gastroschisis And Early Infant Nutrition (GAIN) Study aims to test the feasibility of an early feeding approach in neonates with simple gastroschisis. METHODS: This two-site single-arm feasibility trial aims to enroll neonates with presumed simple gastroschisis over 30 months. The intervention has two main components: Replogle suction tube removal within 24 h of abdominal closure and starting small-volume human milk feeds within 48 h of abdominal closure. Feeding volume will be advanced as tolerated, following the University of California Fetal Consortium pathway, which is standard care. Feasibility outcomes include enrollment rate, protocol adherence, fidelity, and withdrawal rate. Exploratory outcomes include hospitalization length, time to full feeds, duration of parenteral nutrition, use of human milk, breastfeeding rates, and anthropometric measurements. Safety measures involve monitoring for feeding-related complications, infections, and unexpected surgical interventions. DISCUSSION: This feasibility trial of early feeding initiation in neonates with gastroschisis is a critical step towards addressing the need for a standardized feeding approach. Findings will inform future clinical trials and challenge the need for prolonged bowel rest. Standardizing early feeding practices could reduce practice variation, improve gut motility, and the overall health of neonates with gastroschisis. SYSTEMATIC REVIEW REGISTRATION: NCT06878950. CI - (c) 2026. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. FAU - Cacho, Nicole T AU - Cacho NT AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. FAU - Cera, Anjali J AU - Cera AJ AD - Department of Pediatrics, Kaiser Permanente, Roseville, CA, 95661, USA. FAU - Tancredi, Daniel J AU - Tancredi DJ AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. FAU - Wieck, Minna M AU - Wieck MM AD - Department of Surgery, University of California Davis, Sacramento, CA, 95817, USA. FAU - Anderson, Jamie E AU - Anderson JE AD - Department of Surgery, University of California Davis, Sacramento, CA, 95817, USA. FAU - Leegwater, Alexandra J AU - Leegwater AJ AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. FAU - Uy, Cherry C AU - Uy CC AD - Department of Pediatrics, University of California, Irvine, Irvine, CA, 92697, USA. FAU - Guner, Yigit S AU - Guner YS AD - Department of Surgery, Children's Hospital of Orange County, Orange, CA, 92868, USA. FAU - DeUgarte, Daniel A AU - DeUgarte DA AD - Department of Surgery, University of California, Los Angeles, CA, 90095, USA. FAU - Rosenthal, Jennifer L AU - Rosenthal JL AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. FAU - Calkins, Kara L AU - Calkins KL AD - Department of Pediatrics, University of California, Los Angeles, CA, 90095, USA. FAU - Bautista, Geoanna M AU - Bautista GM AUID- ORCID: 0000-0003-0245-9272 AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. gmbautista@health.ucdavis.edu. CN - University of California Fetal Consortium (UCfC) LA - eng SI - ClinicalTrials.gov/NCT06878950 GR - K08 DK143334/DK/NIDDK NIH HHS/United States GR - KL2 TR001859/TR/NCATS NIH HHS/United States GR - L40 DK137356/DK/NIDDK NIH HHS/United States GR - UL1 TR001860/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260615 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13495323 OTO - NOTNLM OT - Early feeds OT - Feasibility trial OT - Gastroschisis OT - Neonatal intensive care unit OT - Rare disease COIS- Declarations. Ethics approval and consent to participate: If the parent is eligible and agrees to participate, they must sign a paper consent form within the first 24 h of abdominal closure. If signed during pregnancy, the infant will undergo additional screening at delivery to ensure they meet study criteria. The signed form, containing identifiable information, will be stored in a locked cabinet in the NICU, accessible only to study staff. A copy will be uploaded to the electronic medical records of either the mother, the infant, or both. Parents will receive a signed copy for their records. Obtaining local IRB-approved informed consent is a basic ethical obligation and a legal requirement for researchers unless waived by the IRB. Informed consent is a key protection defined by: HHS regulations at 45 CFR part 46 and FDA regulations at 21 CFR part 50. Competing interests: KLC has received research support from Fresenius Kabi, Mead Johnson, and Premier Research. KLC has served as an advisor for Fresenius Kabi, Mead Johnson, Baxter, and Prolacta. KLC serves as an institutional principal investigator, with no salary funding, for a consortium database sponsored by Mead Johnson. All other authors declare that they have no competing interests. FIR - Ong, Twila IR - Ong T FIR - Bedford-Mu, Christa IR - Bedford-Mu C FIR - Wright, Katy IR - Wright K FIR - Usher, Kenzie IR - Usher K EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:36 PMCR- 2026/06/15 CRDT- 2026/06/16 00:49 PHST- 2025/09/10 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/16 06:36 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:49 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1186/s40814-026-01860-4 [pii] AID - 1860 [pii] AID - 10.1186/s40814-026-01860-4 [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Jun 15;12(1):123. doi: 10.1186/s40814-026-01860-4. PMID- 42298718 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260825 LR - 20260827 IS - 1756-0381 (Print) IS - 1756-0381 (Electronic) IS - 1756-0381 (Linking) VI - 19 IP - 1 DP - 2026 Jun 15 TI - Clinically actionable classification tool for childhood and adult atopic dermatitis via explainable AI: a retrospective cross-sectional study optimizing diagnostic accuracy. LID - 10.1186/s13040-026-00565-x [doi] LID - 66 AB - BACKGROUND: Despite the critical role of early identification in managing atopic dermatitis (AD), current studies are limited by the absence of adult-specific risk stratification models and imbalanced cohort data, hindering effective risk profiling. OBJECTIVE: We aimed to address this deficiency by developing models for AD diagnostic classification through robust machine learning techniques, with a focus on integrating personalized risk factors to improve the identification and characterization of AD in both children and adults. METHODS: The study employed multiracial cross-sectional data from the National Health And Nutrition Examination Survey (NHANES) in which children (age < 20) and adults (age >/= 20) with self-reported AD endpoints were extracted from 1999 to 2006. Comprehensive class balancing and machine learning techniques were employed to develop a set of AD classification models for different age groups. The models were assessed using five-fold cross-validation for internal validation and internal hold-out validations using a test set composed of raw data. The optimal model for each subgroup, with the best accuracy to classify AD presence, was determined and assessed by ACC, F1-score, MCC, and ROC curve. Key features and their contributions to each classification decision are interpreted by permutation feature importance (PFI) and SHapley Additive explanations (SHAP). We compared and further analyzed demographic and nutritional indicators that have significant associations. RESULTS: Of 22,635 qualified participants, 1118 (13.47%) children and 1732 (12.80%) adults were identified as having AD. The pronounced class imbalance within the dataset led to baseline models yielding accuracies in the range of merely 0.500-0.503. Following the implementation of class balancing techniques and diverse modeling methods, the refined model, utilizing accessible variables from both children and adults, achieved markedly enhanced performance (ACC: 0.835-0.885, F1-score: 0.834-0.884, AUC: 0.913-0.957). Explainable AI revealed opposing effects of dietary antioxidants between children and adults, highlighting age-specific associated mechanisms. CONCLUSION: The classification models for both childhood and adult AD have demonstrated robust discriminative ability and potential utility for case identification in both internal and internal hold-out validations. These models address the challenge in accurate, individualized classification for childhood and adult AD, demonstrating strong discriminative potential in our validation cohorts. We have developed a novel AD diagnostic identification system specifically for both children and adults based on readily accessible demographic, clinical, and nutritional features, which enable the characterization of individuals with a high probability of having AD and the pinpointing of their associated features. This provides a methodological foundation for future research into early management strategies for AD, which could ultimately aim to minimize adverse impacts and modify disease progression. CI - (c) 2026. The Author(s). FAU - Zhou, Rong AU - Zhou R AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. FAU - Zhang, Weiming AU - Zhang W AD - Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei, 430022, China. FAU - Zhou, Lingyue AU - Zhou L AD - Institute of Innovation and Applied Research, Hunan University of Chinese Medicine, Changsha, 410208, China. FAU - Zhu, Qin AU - Zhu Q AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. FAU - Zhang, Jinqing AU - Zhang J AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. FAU - Wang, Shiyu AU - Wang S AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. FAU - Wang, Chang AU - Wang C AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. 2005040@hnucm.edu.cn. LA - eng PT - Journal Article DEP - 20260615 PL - England TA - BioData Min JT - BioData mining JID - 101319161 PMC - PMC13505055 OTO - NOTNLM OT - Atopic dermatitis OT - Class imbalance OT - Classification model OT - Explainable artificial intelligence OT - Machine learning COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:36 PMCR- 2026/06/15 CRDT- 2026/06/16 00:48 PHST- 2025/12/03 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/06/16 06:36 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:48 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1186/s13040-026-00565-x [pii] AID - 565 [pii] AID - 10.1186/s13040-026-00565-x [doi] PST - epublish SO - BioData Min. 2026 Jun 15;19(1):66. doi: 10.1186/s13040-026-00565-x. PMID- 42298498 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260909 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 26 IP - 1 DP - 2026 Jun 15 TI - Health-promoting lifestyle among women living in suburban areas of northeastern Iran: A cross-sectional study. LID - 10.1186/s12905-026-04605-w [doi] LID - 423 AB - INTRODUCTION: Women, especially in urban marginalized areas, face a set of challenges and limitations in the field of health promotion. Considering the key role of women in family and community health, and their vulnerability in marginalized conditions, this study aimed to examine health-promoting lifestyle in women living in urban marginalized areas, to identify their needs and provide a foundation for designing evidence-based interventions and effective policies to improve women's health. METHODS: This cross-sectional, descriptive-analytical study was conducted in 2025 on 295 women living in a suburban area of Mashhad, northeastern Iran, using multi-stage sampling. After ethical approval and written informed consent, participants completed a demographic questionnaire and the Health-Promoting Lifestyle Profile II (HPLP-II), whose Persian version has confirmed validity and reliability in Iran (Cronbach's alpha = 0.82). Data were analyzed in SPSS version 25 using descriptive and analytical statistics including Kruskal-Wallis, Mann-Whitney U, and Spearman correlation tests with a significance level of p < 0.05. RESULTS: The mean age of the women was 37.25 +/- 10.63 years and mean total health-promoting lifestyle score was 127.87 +/- 26.91, with the highest mean score in the spiritual growth dimension (26.02 +/- 5.58). Analyses showed a significant inverse relationship between age, number of children, BMI, and lifestyle score (P < 0.05), and lower lifestyle scores among women with chronic diseases such as hypertension and hyperlipidemia (P < 0.05). A significant increase in lifestyle score with higher family income (P < 0.05), and differences in mean lifestyle scores based on marital status and educational level (P < 0.05). DISCUSSION AND CONCLUSION: The findings indicate that the overall level of health-promoting lifestyle among women living in marginalized areas is moderate and associated with various individual and social factors. These findings suggest that improving women's health in such settings requires attention to both personal behaviors and broader economic and educational contexts. Further studies are recommended to design and assess interventions that effectively address these factors. CI - (c) 2026. The Author(s). FAU - Rastgoo, Faezeh AU - Rastgoo F AD - Student Research Committee, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Davoudi, Nayyereh AU - Davoudi N AD - Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Najafi, Samane AU - Najafi S AD - Student Research Committee, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Talab, HamidReza Zendeh AU - Talab HZ AD - Department of Community Health Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran. zendehtalabhr@mums.ac.ir. LA - eng GR - 4040112/Mashhad University of Medical Sciences/ PT - Journal Article DEP - 20260615 PL - England TA - BMC Womens Health JT - BMC women's health JID - 101088690 SB - IM MH - Humans MH - Female MH - Iran MH - Cross-Sectional Studies MH - Adult MH - Middle Aged MH - *Suburban Population/statistics & numerical data MH - *Healthy Lifestyle MH - *Health Promotion MH - *Women's Health MH - Surveys and Questionnaires MH - *Life Style PMC - PMC13495348 OTO - NOTNLM OT - Health Promotion OT - Iran OT - Life Style OT - Suburban Population OT - Women COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Mashhad University of Medical Sciences, Mashhad, Iran, under the ethics code IR.MUMS.NURSE.REC.1404.041. All procedures were conducted in accordance with the Declaration of Helsinki and relevant ethical guidelines and regulations. Eligible women were invited to participate after receiving information about the study objectives and procedures, and written informed consent was obtained from all participants prior to data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 06:35 MHDA- 2026/08/21 05:35 PMCR- 2026/06/15 CRDT- 2026/06/16 00:38 PHST- 2025/09/07 00:00 [received] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/08/21 05:35 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:38 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1186/s12905-026-04605-w [pii] AID - 4605 [pii] AID - 10.1186/s12905-026-04605-w [doi] PST - epublish SO - BMC Womens Health. 2026 Jun 15;26(1):423. doi: 10.1186/s12905-026-04605-w. PMID- 42298474 OWN - NLM STAT- Publisher LR - 20260616 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) DP - 2026 Jun 15 TI - First trimester, one-tube screening for pregnancy complications via placental biomarkers. LID - 10.1186/s12884-026-09417-2 [doi] AB - BACKGROUND: Early pregnancy screening to identify high-risk women for targeted prevention is effective for reducing pregnancy complications. Placental biomarkers, including PlGF and PAPP-A, are linked to adverse outcomes, yet their combined predictive value for pregnancy complications remains unclear. Here, a retrospective cohort study was conducted to assess first-trimester prediction models incorporating PlGF, PAPP-A, and maternal factors for major obstetric complications. METHODS: This was a retrospective cohort study using data that were prospectively collected during first-trimester screening. A cohort study was conducted at the International Peace Maternity and Child Health Hospital of China Welfare Institution (Shanghai, China) from December 2021 to October 2022. A total of 4046 participants were recruited during the first-trimester screening, excluding those with miscarriages and those without delivery data. In our routine screening, all pregnant women were tested for placental growth factor (PlGF) and pregnancy-associated plasma protein A (PAPP-A). The mean arterial pressure (MAP) and uterine artery pulsatility index (UTPI) were also measured in accordance with the Fetal Medicine Foundation guidelines, along with maternal characteristics and medical history collected via face-to-face interviews. Multivariable logistic regression was used for model development. Model performance was evaluated by the area under the receiver operating characteristic curve (AUC). RESULTS: Among 4046 initially recruited participants, data from 3910 participants regarding fetal growth restriction (FGR), gestational diabetes mellitus (GDM), placenta previa and preterm birth (PTB) were analyzed. For the PE analysis, a subgroup of 1,588 women with available UTPI measurements was evaluated. The best models for predicting FGR were the indicator height, PAPP-A levels, and PlGF levels, with an AUC of 0.742 (95% CI: 0.633-0.851). Regarding GDM prediction, the model including BMI and PAPP-A levels had the best AUC (0.667, 95% CI: 0.622-0.713). With respect to placenta previa prediction, the model including age and PlGF levels had the best AUC (0.765, 95% CI: 0.588-0.941). For PTB, indicators such as the PlGF multiples of the median (MoM), PAPP-A, type I diabetes and systemic lupus erythematosus had the best performance, with an AUC of 0.665 (95% CI: 0.553-0.776). For PE screening using the Fetal Medicine Foundation (FMF) competing-risk model (PAPP-A, PIGF, MAP, and UTPI), the model achieved an AUC of 0.847 for preterm PE (< 37 weeks), with a detection rate of 50.00%, and an AUC of 0.777 for term PE (>/= 37 weeks), with a detection rate of 95.12% at the recommended risk cutoff of 1 in 100. CONCLUSION: First-trimester screening using PlGF, PAPP-A, and maternal factors shows preliminary associations with common obstetric complications, suggesting the potential utility of these biomarkers in early risk stratification, providing a proof-of-concept tool for early risk stratification and improved management of high-risk pregnancies to reduce maternal and fetal morbidity. However, these models require validation in larger, more diverse populations before clinical consideration. CI - (c) 2026. The Author(s). FAU - Hua, Renyi AU - Hua R AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Li, Shuyuan AU - Li S AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Han, Xu AU - Han X AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Tang, Ziyuan AU - Tang Z AD - Revvity, Ltd., Women and Children Diagnosis, Shanghai, China. FAU - Ye, Baoying AU - Ye B AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Tan, Yuru AU - Tan Y AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Wang, Shan AU - Wang S AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Sun, Jinling AU - Sun J AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Cheng, Weiwei AU - Cheng W AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. wwcheng29@163.com. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. wwcheng29@163.com. FAU - Wang, Yanlin AU - Wang Y AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. wyanlin@163.com. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. wyanlin@163.com. LA - eng PT - Journal Article DEP - 20260615 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM OTO - NOTNLM OT - Fetal growth restriction OT - First trimester OT - Placenta previa OT - Placental biomarkers OT - Pre-eclampsia OT - Pregnancy OT - Preterm birth COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Review Board of the International Peace Maternity and Child Health Hospital Affiliated with the Shanghai JiaoTong University School of Medicine (Approval No. GKLW2019-20).Written informed consent was obtained from all participants prior to enrollment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:35 CRDT- 2026/06/16 00:37 PHST- 2025/02/13 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/16 06:35 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:37 [entrez] AID - 10.1186/s12884-026-09417-2 [pii] AID - 10.1186/s12884-026-09417-2 [doi] PST - aheadofprint SO - BMC Pregnancy Childbirth. 2026 Jun 15. doi: 10.1186/s12884-026-09417-2. PMID- 42298466 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 15 TI - Impact of early postoperative enteral nutrition initiation timing on infection rate and nutritional status in children with congenital heart disease. LID - 10.1186/s12887-026-06975-4 [doi] LID - 784 AB - BACKGROUND: The optimal timing for initiating enteral nutrition after congenital heart disease surgery remains controversial. This study aimed to evaluate the impact of early versus delayed enteral nutrition initiation on postoperative infection rate and nutritional status in pediatric congenital heart disease patients. METHODS: A retrospective cohort study was conducted on 246 children (aged 1 month to 3 years) who underwent congenital heart disease surgery between January 2021 and December 2023. Patients were divided into early enteral nutrition group (enteral nutrition initiated 24 h postoperatively, n = 118). Primary outcomes included postoperative infection rate and nutritional parameters. Secondary outcomes included ICU length of stay, hospital length of stay, and mechanical ventilation duration. RESULTS: The early enteral nutrition group demonstrated significantly lower nosocomial infection rate (14.84% vs. 27.12%, P = 0.016) and surgical site infection rate (3.91% vs. 10.17%, P = 0.047). Postoperative day 7 serum albumin (35.62 +/- 4.18 vs. 32.47 +/- 5.23 g/L, P < 0.001) and prealbumin levels (168.35 +/- 42.67 vs. 142.58 +/- 38.94 mg/L, P < 0.001) were significantly higher in the early enteral nutrition group. The early enteral nutrition group also showed shorter ICU stay (5.38 +/- 2.14 vs. 7.25 +/- 3.42 days, P < 0.001) and hospital stay (12.45 +/- 4.36 vs. 16.82 +/- 5.78 days, P < 0.001). Multivariate logistic regression identified delayed enteral nutrition initiation as an independent risk factor for nosocomial infection (OR = 2.18, 95% CI: 1.12-4.24, P = 0.022). CONCLUSIONS: In this retrospective cohort study, early enteral nutrition initiation within 24 h after congenital heart disease surgery was associated with reduced infection rates, improved nutritional status, and shorter hospital stay in pediatric patients, predominantly those undergoing repair of septal defects. These observations suggest a potential benefit of early enteral nutrition in selected pediatric cardiac surgery patients; however, prospective validation is warranted before broad implementation, given the inherent limitations of the retrospective design and the predominantly lower-complexity patient population studied. CI - (c) 2026. The Author(s). FAU - Ye, Li AU - Ye L AD - Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. xiaoyeer2025@163.com. FAU - Chen, Maoting AU - Chen M AD - Department of Nursing, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. FAU - Wei, Qianling AU - Wei Q AD - Department of Nursing, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. FAU - Wang, Yue AU - Wang Y AD - Department of Nursing, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. LA - eng PT - Journal Article DEP - 20260615 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Heart Defects, Congenital/surgery MH - Retrospective Studies MH - Infant MH - *Enteral Nutrition/methods MH - *Nutritional Status MH - Female MH - Child, Preschool MH - Length of Stay/statistics & numerical data MH - Male MH - Time Factors MH - *Postoperative Care/methods MH - *Cross Infection/epidemiology/prevention & control MH - *Surgical Wound Infection/epidemiology/prevention & control MH - *Postoperative Complications/prevention & control/epidemiology MH - Respiration, Artificial/statistics & numerical data MH - Cardiac Surgical Procedures PMC - PMC13508520 OTO - NOTNLM OT - Congenital heart disease OT - Enteral nutrition OT - Infection OT - Nutritional status OT - Pediatric cardiac surgery COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of West China Hospital of Sichuan University (approval number: 2025PS1899K). Given the retrospective nature of this study, the requirement for informed consent was waived by the Institutional Review Board of West China Hospital of Sichuan University in accordance with the national regulations for medical research involving human subjects. All study participants were minors (under the age of 16 years), and although individual informed consent was waived for this retrospective analysis, all included patients' parents or legal guardians had provided written informed consent for the original medical procedures and the use of anonymized medical data for research purposes at the time of hospital admission, as per institutional policy. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 06:35 MHDA- 2026/08/26 05:36 PMCR- 2026/06/15 CRDT- 2026/06/16 00:36 PHST- 2026/01/22 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/08/26 05:36 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:36 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1186/s12887-026-06975-4 [pii] AID - 6975 [pii] AID - 10.1186/s12887-026-06975-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 15;26(1):784. doi: 10.1186/s12887-026-06975-4. PMID- 42298014 OWN - NLM STAT- Publisher LR - 20260615 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 15 TI - Nutritional screening predicts prolonged stay in LMIC pediatric oncology settings: SCAN validation in Brazilian children. LID - 10.1038/s41390-026-05200-3 [doi] AB - BACKGROUND: Malnutrition affects 50-90% of children with cancer in low- and middle-income countries (LMICs) and worsens clinical outcomes. The Nutrition Screening Tool for Childhood Cancer (SCAN) is cancer-specific but has not been validated in Brazilian Portuguese. We aimed to evaluate the diagnostic accuracy of the Brazilian Portuguese SCAN (SCAN pt-BR) against STRONGkids and to examine its association with prolonged hospitalization and ICU admission. METHODS: Prospective diagnostic-accuracy study at a tertiary pediatric oncology center in Brazil (February-December 2021). Consecutive inpatients aged 1-18 years with expected stay >/=48 h were screened within 24-48 h of admission by pediatric dietitians using SCAN pt-BR and STRONGkids. RESULTS: Of 262 children (median age 8.8 years, 52.7% male, 41.2% hematologic malignancies), 70.2% were classified as at risk by SCAN pt-BR. Against STRONGkids >/=4, SCAN showed sensitivity 94.6%, specificity 43.2%, and ROC-AUC 0.863. SCAN risk independently predicted prolonged stay (adjusted OR 2.33, 95% CI 1.29-4.30, p = 0.006) but not ICU admission (adjusted OR 0.96, p = 0.899). CONCLUSION: SCAN pt-BR showed adequate screening performance and independently predicted prolonged hospitalization in Brazilian children with cancer. These results support its use for admission nutritional triage in LMIC pediatric oncology settings. IMPACT: SCAN identified 70.2% of children as at nutritional risk and predicted prolonged hospitalization (adjusted OR 2.33, 95% CI 1.29-4.30) independently of age, tumor group, and STRONGkids classification. Against STRONGkids high-risk classification, SCAN pt-BR showed high sensitivity (94.6%), high negative predictive value (93.6%), and ROC-AUC of 0.863. Gastrointestinal symptoms, poor oral intake, and recent weight loss were the most frequently endorsed symptom-related items that children classified as at nutritional risk, suggesting that SCAN detects acute nutritional deterioration rather than static disease characteristics. Routine application at admission could direct early dietetic referral to children most likely to require prolonged inpatient care. CI - (c) 2026. The Author(s). FAU - Duarte, Mariana Murra AU - Duarte MM AD - Department of Clinical Nutrition, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - da Silva, Marielle Ferreira AU - da Silva MF AD - Department of Clinical Nutrition, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - Alexandre, Maynara Cristina AU - Alexandre MC AD - Department of Clinical Nutrition, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - Fermino, Marise Lopes AU - Fermino ML AD - Barretos Medical School, Faculdade de Ciencias da Saude "Dr Paulo Prata" (FACISB), Barretos, SP, Brazil. FAU - do Nascimento, Ana Laura Balduino AU - do Nascimento ALB AD - Barretos Medical School, Faculdade de Ciencias da Saude "Dr Paulo Prata" (FACISB), Barretos, SP, Brazil. AD - "Innovation in Healthcare" Post-graduation Program, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - de Oliveira, Wilson Elias Jr AU - de Oliveira WE Jr AUID- ORCID: 0000-0001-9812-6282 AD - "Innovation in Healthcare" Post-graduation Program, Barretos Cancer Hospital, Barretos, SP, Brazil. woliveirajr.cipe@gmail.com. AD - Department of Pediatric Surgery, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. woliveirajr.cipe@gmail.com. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: This study was conducted in accordance with the Declaration of Helsinki and Brazilian national research ethics guidelines. The protocol was approved by the Research Ethics Committee of the Hospital de Cancer de Barretos (REB #3.827.548/2019). Written informed consent was obtained from all parents or legal guardians before enrollment. EDAT- 2026/06/16 00:33 MHDA- 2026/06/16 00:33 CRDT- 2026/06/15 23:37 PHST- 2026/02/11 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/05/12 00:00 [revised] PHST- 2026/06/16 00:33 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 23:37 [entrez] AID - 10.1038/s41390-026-05200-3 [pii] AID - 10.1038/s41390-026-05200-3 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 15. doi: 10.1038/s41390-026-05200-3. PMID- 42298003 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20261023 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 15 TI - Dietary patterns are associated with premenstrual symptoms: a cross-sectional study among women from Central Europe. LID - 10.1038/s41598-026-58236-0 [doi] LID - 27317 AB - To date, only a few studies have examined the relationship between dietary patterns and premenstrual syndrome (PMS), and these have been limited to Asian populations with inconclusive results, while studies in European populations are lacking. Therefore, this study aimed to examine the associations between dietary patterns and the severity of PMS in young women from a European population. This cross-sectional study included 609 women aged 18-35 years. Premenstrual symptoms and their severity were assessed using the validated Premenstrual Symptoms Screening Tool, dietary intake data were collected using a semiquantitative food frequency questionnaire, and dietary patterns were determined via K-means clustering of 13 food groups. Three dietary patterns (DPs) were identified: Healthy-DP, Western-DP, and Low-food-DP (characterized by low consumption of all food groups). In the multivariable-adjusted logistic regression model, compared with the Healthy-DP, women adhering to the Western-DP had significantly higher odds of being classified into the Severe-PMS group (OR:2.35, 95%CI:1.02-5.44). Similarly, those following the Low-food-DP had higher odds of both Moderate-PMS (OR:2.92, 95%CI:1.09-7.84) and Severe-PMS (OR:3.01, 95% CI:1.14-7.92). These findings highlight potential associations between dietary patterns and PMS severity; however, due to the cross-sectional design of the study, no causal conclusions can be drawn. CI - (c) 2026. The Author(s). FAU - Granda, Dominika AU - Granda D AD - Department of Nutrition Physiology, Institute of Sport, National Research Institute, Trylogii 2/16, Warsaw, 01-982, Poland. dominika.granda@insp.pl. AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, Warsaw, 02-787, Poland. dominika.granda@insp.pl. FAU - Szmidt, Maria Karolina AU - Szmidt MK AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, Warsaw, 02-787, Poland. maria_szmidt@sggw.edu.pl. FAU - Jarmuzek-Orska, Patrycja AU - Jarmuzek-Orska P AD - Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Zlotej Jesieni 1, Cracow, 31-826, Poland. FAU - Kaluza, Joanna AU - Kaluza J AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, Warsaw, 02-787, Poland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260615 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - *Premenstrual Syndrome/epidemiology/etiology MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - Adolescent MH - *Diet/adverse effects MH - Europe/epidemiology MH - *Feeding Behavior MH - Surveys and Questionnaires PMC - PMC13530195 OTO - NOTNLM OT - Cluster analysis OT - Diet OT - Dietary patterns OT - Nutrition OT - Premenstrual syndrome OT - Premenstrual syndrome screening tool COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 00:33 MHDA- 2026/09/01 05:41 PMCR- 2026/06/15 CRDT- 2026/06/15 23:37 PHST- 2025/10/23 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/01 05:41 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 23:37 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1038/s41598-026-58236-0 [pii] AID - 58236 [pii] AID - 10.1038/s41598-026-58236-0 [doi] PST - epublish SO - Sci Rep. 2026 Jun 15;16(1):27317. doi: 10.1038/s41598-026-58236-0. PMID- 42297455 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 15 TI - Tuberculosis death prediction calculator for prospective use at diagnosis in resource-constrained programme settings: a statewide cohort study. PG - e116110 LID - 10.1136/bmjopen-2025-116110 [doi] LID - e116110 AB - OBJECTIVES: To develop predictive models for early and overall tuberculosis (TB) deaths for prospective use at TB diagnosis in resource-constrained TB programme settings. DESIGN: Statewide cohort study using routinely captured secondary data. SETTING: With the majority of TB deaths being early (within 2 months), India's TB programme's information management system (Ni-kshay)-dependent death prediction models (using age, gender, TB site, previous treatment, microbiological confirmation, HIV, diabetes and bank account availability) are not feasible for prospective use, as few variables are captured at diagnosis. Utilising routinely captured triage variables for severe illness at diagnosis (body mass index, pedal oedema, respiratory rate, oxygen saturation and ability to stand without support) from an ongoing statewide and state-specific differentiated TB care initiative to reduce TB deaths in Tamil Nadu state (southern India, 80 million population with 0.1 million annual notifications), robust models for prospective use were developed. PARTICIPANTS: Adults (aged >/=15 years) with TB (not known to be drug-resistant at diagnosis) that were notified from public facilities of Tamil Nadu from July 2022 to June 2023. OUTCOME MEASURES: Early and overall (within 12 months of notification) TB deaths. Area under the receiver operating characteristic curve (AUC) was used to assess accuracy of models built using modified Poisson regression. RESULTS: Among 55 971 adults, the overall death rate was 7.4%, and 67.9% of the deaths were early. In predicting overall deaths, accuracy of the model using all Ni-kshay variables (AUC 0.716 (95% CI 0.707 to 0.725)) was as good as the model using triage variables for severe illness only (AUC 0.701 (95% CI 0.691 to 0.711)). To the latter, adding potentially capturable Ni-kshay variables at diagnosis (age, gender, TB site, previous treatment and microbiological confirmation) significantly improved model accuracy (AUC 0.754 (95% CI 0.745 to 0.763)). Further addition of remaining Ni-kshay variables did not improve accuracy significantly. Death prediction equations were generated for these models. CONCLUSION: Simple and easily measurable triage variables for severe illness should be routinely captured at TB diagnosis. A death prediction calculator (http://44.208.93.99/) based on these variables (specifically triage variables for severe illness combined with age, gender, TB site, previous treatment and microbiological confirmation) may be used by Indian states and high TB burden countries seeking scalable, data-driven interventions to reduce TB deaths. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Shanmugasundaram, Suseendar AU - Shanmugasundaram S AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Shewade, Hemant Deepak AU - Shewade HD AUID- ORCID: 0000-0002-8242-1911 AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India hemantjipmer@gmail.com. FAU - Srinivasan, Ramalingam AU - Srinivasan R AD - Infectious Disease Epidemiology, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Frederick, Asha AU - Frederick A AD - State TB Office, Government of Tamil Nadu, Chennai, India. FAU - Sabarinathan, Ramasamy AU - Sabarinathan R AD - Computing and Information Sciences, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Harish, Premkumar AU - Harish P AD - ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Balu, Deepan AU - Balu D AD - S.A. Engineering College, Chennai, Chennai, India. FAU - Melfha, Jeen M AU - Melfha JM AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Gayathri, Kumari AU - Gayathri K AD - School of Public Health, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Vijayaprabha, Radhakrishnan AU - Vijayaprabha R AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Jeyakumar, Annadurai AU - Jeyakumar A AD - School of Public Health, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Kabir, Dilsadh AU - Kabir D AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Eraivan, Meikappan AU - Eraivan M AD - State TB Office, Government of Tamil Nadu, Chennai, India. FAU - Bhatnagar, Tarun AU - Bhatnagar T AUID- ORCID: 0000-0002-5603-1418 AD - School of Public Health, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Murhekar, Manoj V AU - Murhekar MV AUID- ORCID: 0000-0002-1720-7628 AD - Infectious Disease Epidemiology, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. LA - eng PT - Journal Article DEP - 20260615 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - India/epidemiology MH - *Tuberculosis/mortality/diagnosis MH - Adult MH - Male MH - Resource-Limited Settings MH - Female MH - Prospective Studies MH - Middle Aged MH - Young Adult MH - Triage MH - Adolescent MH - Cohort Studies MH - ROC Curve PMC - PMC13319640 OTO - NOTNLM OT - Differentiated TB care OT - Operational Research OT - Predictive models OT - Risk stratification OT - TB mortality OT - Triaging for severe illness COIS- Competing interests: None. EDAT- 2026/06/16 00:33 MHDA- 2026/06/16 00:34 PMCR- 2026/06/15 CRDT- 2026/06/15 20:53 PHST- 2026/06/16 00:34 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 20:53 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - bmjopen-2025-116110 [pii] AID - 10.1136/bmjopen-2025-116110 [doi] PST - epublish SO - BMJ Open. 2026 Jun 15;16(6):e116110. doi: 10.1136/bmjopen-2025-116110. PMID- 42297336 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260915 IS - 1097-6833 (Electronic) IS - 0022-3476 (Linking) VI - 297 DP - 2026 Oct TI - Ambulatory Blood Pressure Thresholds and Left Ventricular Hypertrophy in Children Aged 6-12 Years: A Pediatric Nephrology Research Consortium Study. PG - 115194 LID - S0022-3476(26)00222-2 [pii] LID - 10.1016/j.jpeds.2026.115194 [doi] AB - OBJECTIVE: To evaluate the diagnostic performance of ambulatory blood pressure monitoring (ABPM) thresholds for predicting left ventricular hypertrophy (LVH) in children aged 6-12 years. STUDY DESIGN: A retrospective, multicenter study was conducted across 11 Pediatric Nephrology Research Consortium sites and included children aged 6-12 years who underwent ABPM and 2-dimensional echocardiography for diagnostic assessment of elevated BP. The diagnostic accuracy of fixed ABPM thresholds and the current 95th percentile for sex and height were assessed using area under the receiver operating characteristic, sensitivity, specificity, and Youden index. Multivariable logistic regression models, adjusted for age, sex, and body mass index z-score, were used to evaluate associations of ABPM thresholds with LVH. RESULTS: Among 279 children, hypertension was present in 51% and LVH in approximately 20%. Across all systolic and diastolic ABPM thresholds tested, area under the receiver operating characteristic values ranged from 0.5 to 0.6, indicating poor discriminatory performance, including analyses restricted to children without chronic kidney disease or obesity. Although daytime and 24-hour BP thresholds were not significantly associated with LVH, a night-time systolic BP of >/=110 mm Hg and a night-time diastolic BP of >/=70 mm Hg both increased the odds of LVH by approximately 2-fold (OR for night-time SBP, 1.93; 95% CI, 1.07-3.50; P = .03; and OR for night-time DBP, 2.27; 95% CI, 1.08-4.76; P = .03). CONCLUSIONS: In this multicenter cohort of US children aged 6-12 years, percentile-based and fixed ABPM thresholds demonstrated limited ability to discriminate LVH. Night-time systolic and diastolic BPs showed the strongest associations with LVH, underscoring the importance of nocturnal BP assessment. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Jahan, Afsana AU - Jahan A AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. FAU - Schuchman, Matthew AU - Schuchman M AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. FAU - Abdullah, Mahie AU - Abdullah M AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. FAU - McLaughlin, Meghan AU - McLaughlin M AD - Department of Pediatrics, University of Rochester Medical Center, Rochester, NY. FAU - Cadiz, Emilia Maria AU - Cadiz EM AD - Department of Pediatric Nephrology, Phoenix Children Hospital, Phoenix, AZ. FAU - Manchanda, Eshanika AU - Manchanda E AD - Department of Nephrology, Children's Mercy Hospital, University of Missouri School of Medicine, Kansas City, MO. FAU - Chishti, Aftab AU - Chishti A AD - Division of Pediatric Nephrology, Golisano Children's at the University of Kentucky, Lexington, KY. FAU - Murphy, Maggie AU - Murphy M AD - Division of Pediatric Nephrology, Golisano Children's at the University of Kentucky, Lexington, KY. FAU - Twichell, Sarah AU - Twichell S AD - Division pf Pediatric Nephrology, Larner College of Medicine, University of Vermont, Burlington, VT. FAU - Mazo, Alexandra AU - Mazo A AD - Pediatric Nephrology Division, Maria Fareri Children's Hospital, Westchester Medical Center, Boston Children's Health Physicians, New York Medical College, New York, NY; Division of Pediatric Nephrology, Loma Linda University Children's Hospital, Loma Linda, CA. FAU - Samsonov, Dmitry AU - Samsonov D AD - Pediatric Nephrology Division, Maria Fareri Children's Hospital, Westchester Medical Center, Boston Children's Health Physicians, New York Medical College, New York, NY. FAU - Maniar, Aesha AU - Maniar A AD - Division of Pediatric Nephrology, Atrium Health Levine Children's Specialty Center, a Facility of Carolinas Medical Center, Wake Forest, NC. FAU - Kim, Hannah AU - Kim H AD - Division of Pediatric Nephrology, Weill Cornell Medicine, New York, NY. FAU - Lomanta, Francis AU - Lomanta F AD - Division of Pediatric Nephrology & Hypertension, University of Utah, Salt Lake City, UT. FAU - Patibandla, Ashok Chakravarthy AU - Patibandla AC AD - Division of Pediatric Nephrology & Hypertension, University of Utah, Salt Lake City, UT. FAU - Frank, Rachel AU - Frank R AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. FAU - Srivastava, Tarak AU - Srivastava T AD - Department of Nephrology, Children's Mercy Hospital, University of Missouri School of Medicine, Kansas City, MO. FAU - Yamaguchi, Ikuyo AU - Yamaguchi I AD - Division of Pediatric Nephrology & Hypertension, University of Utah, Salt Lake City, UT. FAU - Sethna, Christine AU - Sethna C AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. Electronic address: csethna@northwell.edu. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260615 PL - United States TA - J Pediatr JT - The Journal of pediatrics JID - 0375410 SB - IM MH - Humans MH - Child MH - *Hypertrophy, Left Ventricular/diagnosis/physiopathology MH - Female MH - Male MH - *Blood Pressure Monitoring, Ambulatory MH - Retrospective Studies MH - *Hypertension/diagnosis/complications MH - Blood Pressure MH - ROC Curve MH - Echocardiography MH - Sensitivity and Specificity OTO - NOTNLM OT - ambulatory blood pressure monitoring OT - blood pressure thresholds OT - childhood hypertension OT - left ventricular hypertrophy COIS- Declaration of Competing Interest C.S. is funded by NIH/NHLBI1R01HL162912-01A1 and NIH/NIDDKR01DK131091. C.S. has served on the advisory board for Novo Nordisk, Otsuka, and Apellis and as a consultant to Travere Therapeutics. EDAT- 2026/06/16 00:33 MHDA- 2026/09/15 23:35 CRDT- 2026/06/15 19:35 PHST- 2026/02/04 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/09/15 23:35 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 19:35 [entrez] AID - S0022-3476(26)00222-2 [pii] AID - 10.1016/j.jpeds.2026.115194 [doi] PST - ppublish SO - J Pediatr. 2026 Oct;297:115194. doi: 10.1016/j.jpeds.2026.115194. Epub 2026 Jun 15. PMID- 42297042 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 1678-4782 (Electronic) IS - 0021-7557 (Print) IS - 0021-7557 (Linking) VI - 102 IP - 5 DP - 2026 Sep-Oct TI - Validity of the Khamis-Roche method, relative to bone age, in Portuguese children and adolescents from 11 to 15 years. PG - 101578 LID - S0021-7557(26)00080-X [pii] LID - 10.1016/j.jped.2026.101578 [doi] LID - 101578 AB - OBJECTIVE: to validate maturity status classification, based on %PAH, relative to SA, in a sample of Portuguese children and adolescents of both sexes. METHODS: BA was measured by the Tanner-Whitehouse-3 method, the PAH and %PAH were estimated by the Tanner-Whitehouse-3 method (BA- PAH, % BA-PAH) and the Khamis-Roche method (KR- PAH, %KR- PAH) in 371 children (171 girls). Intraclass Correlation Coefficients and Bland-Altman plots were performance between BA-PAH / BA-%PAH and KR- PAH/%KR- PAH methods. Two-way Analysis of Variance (ANOVA) was made to evaluate the effect of sex and maturity status. RESULTS: The average mean differences between BA-PAH and KR-PAH was 0.2 +/- 4.2 cm in boys and 0.6 +/- 3.1 cm in girls (p > 0.05) and between BA-% PAH and KR-% PAH was -0.1 +/- 2.1% in boys and 0.4 +/- 1.8% in girls (p > 0.05). A high interclass correlation coefficient was higher than 0.91 for BA-% PAH and KR-% PAH. Early maturity status was related to negative differences between BA- KR PAH. CONCLUSION: KR % PAH presented a good agreement and might be a valid estimate of biological maturity status in average maturing children and adolescents. CI - Copyright (c) 2026 The Authors. Published by Elsevier Espana S.L.U. All rights reserved. FAU - Fragoso, Isabel AU - Fragoso I AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Laboratory of Physiology and Biochemistry of Exercise, CIPER, Lisboa, Portugal. Electronic address: ifragoso@fmh.ulisboa.pt. FAU - Albuquerque, Joao AU - Albuquerque J AD - Universidade de Lisboa, Faculdade de Ciencias, Centro de Estatistica e Aplicacoes, Lisboa, Portugal. FAU - Teles, Julia AU - Teles J AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Mathematical Methods Unit, CIPER, Lisboa, Portugal. FAU - Bonito, Fabiana AU - Bonito F AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Laboratory of Physiology and Biochemistry of Exercise, CIPER, Lisboa, Portugal. FAU - Massuca, Luis Miguel AU - Massuca LM AD - Universidade Lusofona de Humanidades e Tecnologias, Faculdade de Educacao Fisica e Desporto, CIEFDES, Lisboa, Portugal; Instituto Superior de Ciencias Policiais e Seguranca Interna, ICPOL, Lisboa, Portugal. FAU - Moura, Fernando Paiva AU - Moura FP AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Laboratory of Physiology and Biochemistry of Exercise, CIPER, Lisboa, Portugal. FAU - Barrigas, Carlos AU - Barrigas C AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Laboratory of Physiology and Biochemistry of Exercise, CIPER, Lisboa, Portugal. FAU - Flores, Luis Alberto AU - Flores LA AD - Autonomous University of Chihuahua, Faculty of Physical Culture Sciences, Chihuahua, Mexico. LA - eng PT - Journal Article PT - Validation Study DEP - 20260703 PL - Brazil TA - J Pediatr (Rio J) JT - Jornal de pediatria JID - 2985188R SB - IM MH - Humans MH - Female MH - Portugal MH - Male MH - Child MH - Adolescent MH - *Age Determination by Skeleton/methods MH - Reproducibility of Results PMC - PMC13355637 OTO - NOTNLM OT - Anthropometry OT - Biological maturation OT - Percentage of adult stature OT - Somatic maturity OT - TW3 COIS- Conflicts of interest The authors report no conflict of interest. EDAT- 2026/06/16 00:33 MHDA- 2026/09/16 23:34 PMCR- 2026/07/03 CRDT- 2026/06/15 19:21 PHST- 2026/01/13 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/09/16 23:34 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 19:21 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - S0021-7557(26)00080-X [pii] AID - 101578 [pii] AID - 10.1016/j.jped.2026.101578 [doi] PST - ppublish SO - J Pediatr (Rio J). 2026 Sep-Oct;102(5):101578. doi: 10.1016/j.jped.2026.101578. Epub 2026 Jul 3. PMID- 28520347 STAT- Publisher DRDT- 20260616 CTDT- 20120308 PB - National Center for Biotechnology Information (US) DP - 2012 TI - Warfarin Therapy and VKORC1 and CYP Genotype. BTI - Medical Genetics Summaries AB - Warfarin (brand name Coumadin) is an anticoagulant (blood thinner). Warfarin acts by inhibiting the synthesis of vitamin K-dependent clotting factors II, VII, IX and X, and is used in the prevention and treatment of various thrombotic disorders (1). Warfarin is a drug with narrow therapeutic index; thus, a small change in its plasma levels can result in concentration-dependent adverse drug reactions or therapeutic failure. As such, the therapeutic dose of warfarin must be tailored for each individual based on response, which is measured by the INR (International Normalized Ratio), and the condition being treated (1). There is a wide inter-individual variability -up to twenty-fold-in the dose of warfarin required to achieve therapeutic anticoagulation, and the time it takes to reach target INR. Approximately half of this variability is caused by both clinical or lifestyle factors (for example, an individual's age, body mass index, gender, diet, smoking status, ethnicity/race, existing conditions, and concomitant medications) and by genetic variants in the VKORC1, CYP2C9 and CYP4F2 genes, and the CYP2C gene cluster rs12777823 variant (1). The VKORC1 and CYP2C9 variants are the most important known genetic determinants of warfarin dosing. Warfarin targets VKORC1, an enzyme involved in vitamin K recycling. A common VKORC1 variant, c.-1639G>A, is associated with warfarin sensitivity and lower dose requirements. The CYP2C9 enzyme metabolizes S-warfarin, the more potent stereoisomer, and CYP2C9 variants with reduced activity are also associated with lower dose requirements (2). The FDA-approved drug label for warfarin states that CYP2C9 and VKORC1 genotype information, when available, can assist in the selection of the initial and maintenance dose of warfarin. The label provides 2 sets of warfarin dosing recommendations, for when the CYP2C9 and VKORC1 genotypes are either known (Table 1) or not known (taking into account clinical factors, the initial dose of warfarin is usually 2-5 mg once daily and maintenance doses are typically 2-10 mg daily) (1). The 2017 Update of the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing provides warfarin dosing recommendations for adults and pediatric individuals. Recommendations from CPIC state that these dosing guidelines are applied after a warfarin dose has been calculated using a validated pharmacogenetic algorithm, which includes genotype information for VKORC1, c.-1639G>A and CYP2C9 (Figure 1) (2). More recently, the Dutch Pharmacogenetics Working Group (DPWG) of the Royal Dutch Association for the Advancement of Pharmacy (KNMP) has published recommendations for the initial standard dose of warfarin (3). A dose reduction is recommended for individuals who are CYP2C9 poor (PM) and intermediate metabolizers (IM) (with the exception of IM with the CYP2C9*1/*2 genotype, no dose change is required), and a dose reduction is recommended for individuals who have 2 copies of the VKORC1 c.-1639G>A variant allele (c.-1639G>A/A) (Table 2) (4, 5). In addition, genetic variation in the CYP4F2 gene and a variant near the CYP2C gene cluster, rs12777823, have been associated with warfarin dosing. The CYP4F2*3 variant is associated with a modest increase in warfarin dose requirements, notably in individuals with European or Asian ancestry who are more likely to have this variant allele than other ancestral populations. Individuals with African ancestry are more likely than other ancestral groups to have the rs12777823 A/G or A/A genotype that has been associated with decreased warfarin dose requirements. FAU - Dean, Laura AU - Dean L AD - NCBI FAU - Kane, Megan AU - Kane M AD - NCBI LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Warfarin OT - warfarin therapy OT - Coumadin OT - warfarin response OT - coumadin response OT - anticoagulation OT - blood thinner OT - VKORC1 OT - CYP2C9 OT - CYP4F2 OT - INR EDAT- 2026/06/16 00:00 CRDT- 2026/06/16 00:00 AID - NBK84174 [bookaccession] PMID- 42296607 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20261006 IS - 1879-1409 (Electronic) IS - 0305-4179 (Linking) VI - 52 IP - 8 DP - 2026 Nov TI - Burning questions: ED management of pediatric burns at a non-burn health care system. PG - 108071 LID - S0305-4179(26)00223-8 [pii] LID - 10.1016/j.burns.2026.108071 [doi] AB - INTRODUCTION: American Burn Association (ABA) referral criteria help identify patients to be transferred. Limited data exist on characteristics of patients being transferred and utilization of these criteria at non-burn centers (NBC). OBJECTIVES: To describe pediatric emergency department (ED) disposition practices at a non-burn center and compare these practices to ABA referral criteria. DESIGN/METHODS: Retrospective review of electronic records of patients < 18 years old, with discharge diagnosis of burn at a non-burn healthcare system, from December 2016 to June 2022, was performed. Descriptive statistics and multivariable logistic regression was used to analyze transfer rates and determine odds ratios of different factors, comparing transferred and discharged patients. RESULTS: 1231 cases were identified with 35% transferred. Of the 65% of patients discharged, 52% met ABA referral criteria. For all visits, 64% met at least one ABA criterion, of which 47% were transferred. Infants had greatest odds of transfer (OR 9.62, 95% CI 4.6 - 20.1). Burns to high-risk anatomical zones (OR 5.89, 95% CI 4.1 - 8.4), those with > 20% total body surface area (OR 16.86, 95% CI 4.3 - 66.7) and full/partial thickness burns (OR 11.47, 95% CI 5.5 - 23.9) were also all associated with highest odds of transfer. CONCLUSION: The majority of visits met ABA criteria for transfer to a burn center; however, only about half those qualified were transferred. Some may have been appropriately discharged. Infants, large burns, burns to high-risk anatomic zones, or full/partial thickness burns were more often transferred indicating appropriate adherence to the established guideline. These data suggest that ABA criteria are very broad for pediatrics and do not have face validity for community physicians. Further work is needed to refine pediatric ABA referral criteria. CI - Copyright (c) 2026 Elsevier Ltd and International Society of Burns Injuries. All rights reserved. FAU - Nandavar, Akshay Vivek AU - Nandavar AV AD - Department of Pediatric Emergency Medicine, Corewell Health/William Beaumont University Hospital, Royal Oak, MI, USA. Electronic address: akshayvivek.nandavar@ochsner.org. FAU - Seo, David Seungwoo AU - Seo DS AD - Oakland University William Beaumont School of Medicine, Rochester, MI, USA. FAU - Swor, Robert A AU - Swor RA AD - Department of Emergency Medicine, Corewell Health/William Beaumont University Hospital, Royal Oak, MI, USA. FAU - Menoch, Margaret J A AU - Menoch MJA AD - Department of Pediatric Emergency Medicine, Corewell Health/William Beaumont University Hospital, Royal Oak, MI, USA. LA - eng PT - Journal Article DEP - 20260518 PL - Netherlands TA - Burns JT - Burns : journal of the International Society for Burn Injuries JID - 8913178 SB - IM MH - Humans MH - *Burns/therapy/epidemiology MH - Retrospective Studies MH - Female MH - Child MH - *Emergency Service, Hospital/statistics & numerical data/organization & administration MH - Infant MH - Child, Preschool MH - Male MH - Adolescent MH - *Referral and Consultation/statistics & numerical data MH - *Patient Transfer/statistics & numerical data MH - Emergency Room Visits MH - Logistic Models MH - Body Surface Area MH - Infant, Newborn MH - Patient Discharge/statistics & numerical data MH - Odds Ratio OTO - NOTNLM OT - Burn OT - Emergency department OT - Non-burn center OT - Pediatric OT - Transfer COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/15 18:34 MHDA- 2026/09/16 23:34 CRDT- 2026/06/15 18:01 PHST- 2025/06/25 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/09/16 23:34 [medline] PHST- 2026/06/15 18:34 [pubmed] PHST- 2026/06/15 18:01 [entrez] AID - S0305-4179(26)00223-8 [pii] AID - 10.1016/j.burns.2026.108071 [doi] PST - ppublish SO - Burns. 2026 Nov;52(8):108071. doi: 10.1016/j.burns.2026.108071. Epub 2026 May 18. PMID- 42296558 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260922 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 Jun 15 TI - A Pilot mHealth Text Messaging Program Targeting Parents During the First 2000 Days: Nonrandomized Repeat Cross-Sectional Analysis to Evaluate Feasibility, Engagement, Acceptability, and Potential Effectiveness. PG - e83162 LID - 10.2196/83162 [doi] LID - e83162 AB - BACKGROUND: The first 2000 days can profoundly influence long-term health. Healthy Beginnings for Hunter New England Kids (HB4HNEKids) is an SMS text messaging program delivered alongside routine Child and Family Health Nursing (CFHN) care, which provides families with evidence-based, age- and stage-related preventive health information across the first 2000 days. OBJECTIVE: This pilot study aimed to explore the feasibility, engagement, and acceptability of the HB4HNEKids program. It also aimed to explore the potential effectiveness of the program at 6 and/or 12 months post partum on outcomes including breastfeeding, child diet, child movement, and parental mental well-being. METHODS: During the pilot phase (October 2021 to July 2024), project records were used to assess the number of families enrolled, number of SMS text messages sent (feasibility), and the number of opt outs (engagement). Repeat cross-sectional surveys were conducted at 5-7 months post partum and again at 12-14 months post partum using validated survey instruments. Using convenience sampling methods, survey participants consisted of birthing parents who had received HB4HNEKids and a concurrent nonrandomized comparison group that did not receive the program. Surveys assessed parental self-reported engagement with the messages, program acceptability, breastfeeding status, child diet, child movement, and parental mental well-being. Mixed linear regression analyses were conducted to calculate mean differences and odds ratios. RESULTS: During the pilot phase, HB4HNEKids was delivered to 6243 families (73.4% of families contacted by CFHN). A total of 383 birthing parents completed the survey at 6 months (99/383, 26% receiving HB4HNEKids), and 283 completed the survey at 12 months (104/283, 37% receiving HB4HNEKids). Of the survey participants who received HB4HNEKids (n=200), between 76% and 83% reported that they always or very often read the SMS text messages, spending on average 5-7 minutes engaged with the content. At both survey time points, more than 90% of participants receiving HB4HNEKids agreed that the program was acceptable. Child daily intake of vegetables was significantly higher in the HB4HNEKids group (adjusted mean difference 0.23, 95% CI 0.07-0.40; P=.006) than in the comparison group at 12 months. Parents receiving HB4HNEKids also reported significantly better mental well-being scores (P=.005). While HB4HNEKids participants reported breastfeeding rates 5 percentage points greater than comparison participants at 6 and 12 months, this result was not statistically significant. There were no statistically significant differences between HB4HNEKids, and comparison participant responses related to child movement behaviors. CONCLUSIONS: The HB4HNEKids SMS text messaging program is feasible to deliver at scale alongside routine CFHN care and is highly acceptable and engaging to parents. This pragmatic evaluation of the pilot, embedded into usual care, indicates potential effectiveness of the program for improving child vegetable intakes and parental mental well-being. Further evaluation of this program using robust methodology is needed to determine the effectiveness of this innovative mHealth program across the first 2000 days. CI - (c) Jacklyn Jackson, Nayerra Hudson, Tessa Delaney, Alison L Brown, Sienna Kavalec, Jessica Pinfold, Rebecca Sewter, Hannah McCormick, Rebecca Liackman, Christophe Lecathelinais, Lynda Davies, Luke Wolfenden, Daniel Groombridge, Belinda Tully, Sinead Redman, Tauri Smart, Nafiseh Ghafournia, Paul David Craven, Rachel Sutherland. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Jackson, Jacklyn AU - Jackson J AUID- ORCID: 0000-0001-7633-0418 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. FAU - Hudson, Nayerra AU - Hudson N AUID- ORCID: 0000-0002-0069-1564 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Delaney, Tessa AU - Delaney T AUID- ORCID: 0000-0002-2756-4821 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Brown, Alison L AU - Brown AL AUID- ORCID: 0000-0002-4233-7467 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. FAU - Kavalec, Sienna AU - Kavalec S AUID- ORCID: 0009-0003-7605-4646 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. FAU - Pinfold, Jessica AU - Pinfold J AUID- ORCID: 0009-0006-4308-9430 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Sewter, Rebecca AU - Sewter R AUID- ORCID: 0009-0008-4388-1334 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - McCormick, Hannah AU - McCormick H AUID- ORCID: 0009-0009-2157-244X AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Liackman, Rebecca AU - Liackman R AUID- ORCID: 0009-0008-0958-4598 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Lecathelinais, Christophe AU - Lecathelinais C AUID- ORCID: 0000-0002-8931-473X AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Davies, Lynda AU - Davies L AUID- ORCID: 0000-0002-2747-5589 AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Wolfenden, Luke AU - Wolfenden L AUID- ORCID: 0000-0002-6178-3868 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. FAU - Groombridge, Daniel AU - Groombridge D AUID- ORCID: 0000-0002-8393-6431 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Tully, Belinda AU - Tully B AUID- ORCID: 0009-0006-4626-7466 AD - Hunter New England Local Health District, New Lambton, Australia. AD - Armajun Health Service Aboriginal Corporation, Inverell, Australia. FAU - Redman, Sinead AU - Redman S AUID- ORCID: 0009-0006-8960-5568 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Smart, Tauri AU - Smart T AUID- ORCID: 0009-0008-9204-1788 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Ghafournia, Nafiseh AU - Ghafournia N AUID- ORCID: 0000-0002-7688-5138 AD - Hunter Medical Research Institute, Newcastle, Australia. AD - School of Humanities, Creative Industries and Social Sciences, The University of Newcastle, Callaghan, Australia. AD - Western Sydney Local Health District, Paramatta, Australia. FAU - Craven, Paul David AU - Craven PD AUID- ORCID: 0009-0005-5343-0893 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Sutherland, Rachel AU - Sutherland R AUID- ORCID: 0000-0003-0470-7663 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260615 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - *Text Messaging/statistics & numerical data/standards/instrumentation MH - Pilot Projects MH - Cross-Sectional Studies MH - Female MH - Male MH - *Parents/psychology MH - Feasibility Studies MH - Adult MH - Surveys and Questionnaires MH - Telemedicine/standards/statistics & numerical data MH - Program Evaluation/methods PMC - PMC13270169 OTO - NOTNLM OT - acceptability OT - child health OT - cross-sectional OT - digital health OT - feasibility OT - first 2000 days OT - mHealth OT - text message COIS- Conflicts of Interest: None declared. EDAT- 2026/06/15 18:34 MHDA- 2026/06/16 00:33 PMCR- 2026/06/15 CRDT- 2026/06/15 17:53 PHST- 2025/08/28 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/16 00:33 [medline] PHST- 2026/06/15 18:34 [pubmed] PHST- 2026/06/15 17:53 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - v14i1e83162 [pii] AID - 83162 [pii] AID - 10.2196/83162 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Jun 15;14:e83162. doi: 10.2196/83162. PMID- 42295709 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 163 IP - 6 DP - 2026 Jun TI - Household food insecurity in urban slums and its association with nutritional status of under-five children in Salem District, Tamil Nadu. PG - 838-846 LID - 10.25259/IJMR_2123_2025 [pii] AB - Background and objectives Household food security is defined as physical and economic access to sufficient, safe, and nutritious food for an active and healthy life. Evidence suggests that urban poor are more food insecure (51%-Delhi and 74.6%-Vellore) than rural poor. Food insecurity adversely affects under-five children's nutritional status. This study aimed to assess prevalence, determinants, and its association with child-nutrition in urban slums of Salem district, Tamil Nadu. Methods A community-based cross-sectional study was conducted among 363 randomly selected households between January to September 2023 using multi-stage random sampling. Data were collected from primary-care-givers using a validated-semi-structured-questionnaire (USAID-HFIAS) followed by measurement of daily raw food consumption and anthropometry of under-five children. Statistical analysis was performed in SPSSv16.0 using Chi-square/Fisher's test, ANOVA and regression with P<0.05 taken as significant. Results Household food insecurity prevalence was 82.1%, with 20.1% severe. Mean food consumption was significantly lower among insecure households. Determinants included age/gender of household head, single earning member, dependents, and irregular use of public distribution system. Children with normal nutrition had 2.75 [P<0.05;95% confidence interval (C.I):1.31-5.75] times odds of belonging to secure households. Interpretation and conclusions Food insecurity was closely linked to under-five malnutrition, underscoring the need for interventions addressing affordability and structural factors such as housing, healthcare access, and resource distribution. FAU - Arumugam, Daivik Padmavathi AU - Arumugam DP AD - Department of Community Medicine, Government Namakkal Medical College, Chennai, Tamil Nadu, India. FAU - Ramasamy, Umamaheswari AU - Ramasamy U AD - Institute of Community Medicine, Madras Medical College, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Humans MH - *Food Insecurity MH - *Nutritional Status MH - Female MH - India/epidemiology MH - Poverty Areas MH - Child, Preschool MH - Male MH - Infant MH - Urban Population MH - Cross-Sectional Studies MH - Family Characteristics MH - Food Supply MH - Rural Population MH - Poverty MH - Malnutrition/epidemiology MH - Socioeconomic Factors PMC - PMC13289621 OTO - NOTNLM OT - Food insecurity OT - Nutritional status OT - Preschool OT - Socio-economic factors OT - Urban population COIS- None. EDAT- 2026/06/15 12:55 MHDA- 2026/06/15 12:56 PMCR- 2026/06/01 CRDT- 2026/06/15 11:22 PHST- 2025/08/11 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/06/15 12:56 [medline] PHST- 2026/06/15 12:55 [pubmed] PHST- 2026/06/15 11:22 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.25259/IJMR_2123_2025 [pii] AID - 10.25259/IJMR_2123_2025 [doi] PST - ppublish SO - Indian J Med Res. 2026 Jun;163(6):838-846. doi: 10.25259/IJMR_2123_2025. PMID- 42295704 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260804 IS - 1559-0720 (Electronic) IS - 0163-4984 (Linking) VI - 204 IP - 9 DP - 2026 Sep TI - Effects of iodine content in school meals on the results of iodine nutritional surveys using spot urine samples. PG - 7212-7225 LID - 10.1007/s12011-026-05183-6 [doi] AB - Adequate iodine intake is essential for maintaining thyroid function. School meal iodine content (SMIC) is one of the main sources of iodine for schoolchildren. The median urinary iodine concentration (mUIC) in spot urine samples is a reliable indicator of a population's iodine status. The aim of this study is to explore the association between SMIC and mUIC in school-children aged 6-12 year. From 2013-2023 we estimated the SMIC from school lunch menus and compared it to mUIC. Overall, 15,091 children from 115 elementary schools in 25 regions across Japan were included. The mUIC was 294.5 mug/L suggesting adequate iodine intake. The median value of SMIC over a one-month period was 53.0 mug/meal and there was a positive correlation of mUIC with the SMIC (Spermann r = 0.5040) or the SMIC prior to urine sampling (r = 0.4816). Between the two survey years the mUICs decreased by 31.8 to 77.2% in Rishiri Island, Rebun Island, Nakashibetsu and Hiroshima despite no significant change in SMIC over a one-month period except in Rebun Island. The average SMIC, SMIC consumed immediately prior to urine collection, and the time elapsed between the last school meal and urine collection were possible factors that may influence mUIC values. The high mUIC value observed in our earlier survey was partially due to the influence of school lunches. Although school lunches make a significant contribution to iodine nutrition, SMIC can be a potential pitfall for school-based surveys using spot urine samples. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Fuse, Yozen AU - Fuse Y AUID- ORCID: 0000-0001-6716-8367 AD - Research Committee On Iodine Related Health Problems, Foundation for Growth Science, Tokyo, Japan. fsyzn@fgs.or.jp. FAU - Tsukada, Nobu AU - Tsukada N AD - Institute of Nutrition Sciences, Japan Nutrition University, Saitama, Japan. FAU - Yamaguchi, Mayu AU - Yamaguchi M AD - Department of Nutrition and Dietetics, Kamakura Women's University, Kanagawa, Japan. FAU - Ito, Yoshiya AU - Ito Y AUID- ORCID: 0000-0001-7905-6661 AD - Research Committee On Iodine Related Health Problems, Foundation for Growth Science, Tokyo, Japan. AD - Division of Clinical Medicine, Japanese Red Cross Hokkaido College of Nursing, Kitami, Japan. FAU - Shishiba, Yoshimasa AU - Shishiba Y AD - Research Committee On Iodine Related Health Problems, Foundation for Growth Science, Tokyo, Japan. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Biol Trace Elem Res JT - Biological trace element research JID - 7911509 RN - 9679TC07X4 (Iodine) SB - IM MH - Humans MH - *Iodine/urine/administration & dosage MH - Child MH - *Schools MH - Male MH - Female MH - Japan MH - *Nutrition Surveys MH - *Food Services MH - Nutritional Status OTO - NOTNLM OT - Children OT - Iodine survey OT - School meals OT - Urinary iodine COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Japanese Red Cross Hokkaido College of Nursing (December 19, 2013/No. 170 and March 15, 2018/No. 29-291). Competing Interests: The authors declare no competing interests. EDAT- 2026/06/15 12:52 MHDA- 2026/08/04 12:46 CRDT- 2026/06/15 11:22 PHST- 2026/02/14 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/08/04 12:46 [medline] PHST- 2026/06/15 12:52 [pubmed] PHST- 2026/06/15 11:22 [entrez] AID - 10.1007/s12011-026-05183-6 [pii] AID - 10.1007/s12011-026-05183-6 [doi] PST - ppublish SO - Biol Trace Elem Res. 2026 Sep;204(9):7212-7225. doi: 10.1007/s12011-026-05183-6. Epub 2026 Jun 15. PMID- 42295494 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260922 IS - 1573-2649 (Electronic) IS - 0962-9343 (Print) IS - 0962-9343 (Linking) VI - 35 IP - 8 DP - 2026 Jun 15 TI - Trends in cardiometabolic disease and health-related quality of life in the United States, 2001-2022. LID - 10.1007/s11136-026-04300-1 [doi] LID - 195 AB - PURPOSE: To examine associations between cardiometabolic conditions and health-related quality of life (HRQoL) and evaluate temporal trends in condition-associated HRQoL decrements from 2001 to 2022. METHODS: We analyzed nationally representative data from U.S. adults aged >/= 18 years in the Medical Expenditure Panel Survey (2001-2022), excluding years without BMI data collection (2017, 2019, 2021). HRQoL was measured using EQ-5D utilities mapped from SF-12 scores with a validated algorithm. For each year, survey-weighted multivariable regression models estimated associations of sociodemographic characteristics, BMI, and six cardiometabolic conditions with HRQoL. Temporal trends in condition-associated HRQoL decrements were assessed using meta-regression. To estimate recent average associations, we pooled data from 2015, 2016, 2018, and 2022. RESULTS: HRQoL improved over time, with lower values in 2001-2012 than 2013-2022 and an increase from its lowest value in 2012 (0.873) to highest in 2018 (0.888). Stroke contributed the greatest adjusted HRQoL decrement, followed by heart disease, diabetes, high blood pressure, obesity, and high cholesterol. Diabetes- and heart disease-associated decrements attenuated linearly over time (-0.0500 in 2001 to -0.0414 in 2022 and -0.0611 to -0.0487, respectively) , whereas high blood pressure-associated decrement was greatest around 2012 (-0.0361 in 2001, -0.0404 in 2012, and - 0.0313 in 2022) and obesity-associated decrement was smallest around 2012 (- 0.0311, - 0.0290, and - 0.0370). CONCLUSIONS: Changes in condition-associated HRQoL decrements over time suggest that utility values may not remain constant across calendar years. Smaller decrements for diabetes and heart disease may reflect better treatment and management, whereas the growing obesity-related decrement may indicate changes in the national severity of obesity. These patterns highlight the need for current, nationally representative utility estimates in population health research. CI - (c) 2026. The Author(s). FAU - Yang, Danwei AU - Yang D AUID- ORCID: 0000-0003-3858-4673 AD - Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. FAU - Kim, David D AU - Kim DD AUID- ORCID: 0000-0002-3383-8972 AD - Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. David.Kim@bsd.uchicago.edu. AD - Department of Medicine, University of Chicago, Chicago, IL, USA. David.Kim@bsd.uchicago.edu. LA - eng GR - R01 MD019094/MD/NIMHD NIH HHS/United States GR - R01MD019094/NH/NIH HHS/United States PT - Journal Article DEP - 20260615 PL - Netherlands TA - Qual Life Res JT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JID - 9210257 SB - IM MH - Humans MH - *Quality of Life MH - United States/epidemiology MH - Female MH - Middle Aged MH - Adult MH - Male MH - *Cardiovascular Diseases/epidemiology MH - Aged MH - *Health Status MH - Young Adult MH - Body Mass Index MH - Adolescent MH - Obesity/epidemiology MH - Surveys and Questionnaires PMC - PMC13269321 OAB - Cardiometabolic conditions such as diabetes, heart disease, stroke, high blood pressure, obesity, and high cholesterol are common chronic diseases in the United States and can reduce health-related quality of life. However, it is unclear whether their impact on health-related quality of life has changed over time as disease management and treatment have improved. Using nationally representative survey data from U.S. adults collected between 2001 and 2022, we estimated how much each cardiometabolic condition reduced health-related quality of life and whether the condition-specific estimates have changed over time. Overall health-related quality of life improved between 2001 and 2022, with the greatest gains among older adults. Stroke had the largest negative impact on health-related quality of life, followed by heart disease, diabetes, high blood pressure, obesity, and high cholesterol. The health-related quality-of-life gap between adults with and without diabetes or heart disease has narrowed over time, a pattern consistent with improved disease management and treatment. In contrast, the quality-of-life gap associated with obesity increased in recent years, a pattern consistent with the rise in severe obesity nationally. Researchers and policymakers may use up to date quality of life estimates rather than older figures when evaluating the burden of cardiometabolic disease. Using updated disease-attributable health-related quality of life estimates would better reflect the current burden of cardiometabolic disease. OABL- eng OTO - NOTNLM OT - Cardiometabolic diseases OT - EQ-5D OT - Health-related quality of life (HRQoL) OT - Temporal trends COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: This study used de-identified, publicly available data from the Medical Expenditure Panel Survey, which is conducted by the Agency for Healthcare Research and Quality. No identifiable human subjects data were used. Consent to participate: Not applicable. Consent for publication: Not applicable. Preprint server: A previous version of this manuscript was posted on medRxiv as a preprint. The current manuscript has been revised in response to peer-review comments and differs from the posted preprint. DOI: 10.64898/2026.02.20.26346754. EDAT- 2026/06/15 12:52 MHDA- 2026/06/15 12:53 PMCR- 2026/06/15 CRDT- 2026/06/15 11:18 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/15 12:53 [medline] PHST- 2026/06/15 12:52 [pubmed] PHST- 2026/06/15 11:18 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1007/s11136-026-04300-1 [pii] AID - 4300 [pii] AID - 10.1007/s11136-026-04300-1 [doi] PST - epublish SO - Qual Life Res. 2026 Jun 15;35(8):195. doi: 10.1007/s11136-026-04300-1. PMID- 42295221 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20261008 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Maladaptive exercise: A psychometric investigation. PG - 716-728 LID - 10.1037/pas0001479 [doi] AB - There are multiple conceptualizations of maladaptive exercise with each being assessed by different measures. This has led to challenges in integrating the literature. Better understanding of the underlying processes of maladaptive exercise is needed to better conceptualize the construct. The present study used data from two independent samples, a college student sample (n = 497), identified primarily as female (72%), male (22%), White (38%), and Black (22%), and a sample recruited for their exercise engagement (n = 500), identified primarily as female (41%), male (56%), White (57%), and Black (20%). All participants completed self-report measures, including measures of maladaptive exercise (i.e., the Exercise Dependence Scale-Revised, Exercise Addiction Inventory-3, and Compulsive Exercise Test) and assessments of focal criterion variables for the problematic behavior (i.e., impulsivity, compulsivity, and eating disorder pathology). We used exploratory factor analysis to examine the overlapping and distinct content across measures of maladaptive exercise. We then examined correlations between the focal criterion variables and the measures of maladaptive exercise and latent factors. In both samples, the exploratory factor analysis suggested a four-factor solution reflecting tolerance and structure, impairment, exercise worries, and affect regulation. Our findings highlight the overlapping and distinct qualities of the varying assessment instruments and how those qualities map onto the potential underlying processes of maladaptive exercise. Future work should continue to refine the features of a broad definition of maladaptive exercise and develop a self-report measure that integrates the content from the existing measures. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Schleyer, Brooke AU - Schleyer B AUID- ORCID: 0009-0008-0375-0487 AD - Department of Psychology and Neuroscience, Temple University. FAU - Olino, Thomas M AU - Olino TM AUID- ORCID: 0000-0001-5139-8571 AD - Department of Psychology and Neuroscience, Temple University. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - Female MH - Male MH - Psychometrics MH - Young Adult MH - *Exercise/psychology MH - Adult MH - Adolescent MH - Factor Analysis, Statistical MH - *Behavior, Addictive/psychology/diagnosis MH - *Feeding and Eating Disorders/psychology MH - Impulsive Behavior MH - Compulsive Exercise MH - Self Report MH - Students/psychology EDAT- 2026/06/15 12:52 MHDA- 2026/09/21 17:47 CRDT- 2026/06/15 11:03 PHST- 2026/09/21 17:47 [medline] PHST- 2026/06/15 12:52 [pubmed] PHST- 2026/06/15 11:03 [entrez] AID - 2027-83726-001 [pii] AID - 10.1037/pas0001479 [doi] PST - ppublish SO - Psychol Assess. 2026 Oct;38(10):716-728. doi: 10.1037/pas0001479. Epub 2026 Jun 15. PMID- 42294843 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260819 IS - 1440-1754 (Electronic) IS - 1034-4810 (Print) IS - 1034-4810 (Linking) VI - 62 IP - 8 DP - 2026 Aug TI - The Accuracy of a Commercial Wearable Neonatal Home-Monitoring Device: A Simulation Study. PG - 1509-1519 LID - 10.1111/jpc.70471 [doi] AB - OBJECTIVE: Wearable newborn-monitoring devices are increasingly popular and widely available for home use. One approach includes the use of accelerometer detection of breathing movements. We investigated the accuracy of breathing and apnoea detection by a wearable accelerometer in a simulated environment. DESIGN: This study used simulation as a method to evaluate the performance of a wearable accelerometer-based breathing detection device. A term mannequin fitted with an accelerometer suit wirelessly linked to a mobile app (Goldilocks) was NeoPuff ventilated through a cuffed endotracheal tube. Peak inspiratory pressure (PIP) levels of 5-25 cmH(2)O were delivered with zero end expiratory pressure. Each trial consisted of 30 s of ventilation, followed by simulated apnoea (n = 150). App-based detection and alert times were recorded blinded to ventilation status. Detection accuracy across PIP levels was analyzed using Kruskal-Wallis tests followed by Dunn's multiple comparisons with Bonferroni correction. RESULTS: PIP level affected both apnoea detection (H(4) = 58.9, p < 0.0001) and breathing detection (H(4) = 86.5, p < 0.001) with performance reduced at 5 cmH(2)O compared to higher PIP. Apnoea and breathing detection were most accurate at 20 cmH(2)O. Mean (SD) apnoea detection alarm times ranged between 31(0) and 60(22.6) seconds, with no difference between PIP group (H(4) = 9.3, p > 0.05). CONCLUSIONS: The accelerometer displayed pressure-dependent accuracy, increasing with higher PIP, suggesting a minimum pressure threshold is needed for reliable monitoring. App alert times varied greatly, compounding the accuracy of adverse event detection. To determine their true utility, rigorous investigation of neonatal wearable home-monitoring devices is required. CI - (c) 2026 The Author(s). Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Noone, Amelia N AU - Noone AN AUID- ORCID: 0000-0002-1174-1870 AD - Robinson Research Institute, College of Health, Adelaide University, Adelaide, South Australia, Australia. FAU - Bailey, Danielle N AU - Bailey DN AD - Robinson Research Institute, College of Health, Adelaide University, Adelaide, South Australia, Australia. FAU - Crawford, Tara M AU - Crawford TM AD - Robinson Research Institute, College of Health, Adelaide University, Adelaide, South Australia, Australia. FAU - Richards, Shem AU - Richards S AD - Goldilocks Suit, Adelaide, South Australia, Australia. FAU - Andersen, Chad C AU - Andersen CC AD - Robinson Research Institute, College of Health, Adelaide University, Adelaide, South Australia, Australia. AD - Department of Neonatal Medicine, Women's and Children's Hospital, Adelaide, South Australia, Australia. FAU - Stark, Michael J AU - Stark MJ AUID- ORCID: 0000-0003-1835-8679 AD - Robinson Research Institute, College of Health, Adelaide University, Adelaide, South Australia, Australia. AD - Department of Neonatal Medicine, Women's and Children's Hospital, Adelaide, South Australia, Australia. LA - eng PT - Journal Article DEP - 20260615 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - *Wearable Electronic Devices MH - Infant, Newborn MH - Manikins MH - Monitoring, Physiologic/instrumentation MH - *Accelerometry/instrumentation MH - *Apnea/diagnosis MH - Respiration MH - Equipment Design PMC - PMC13480716 OTO - NOTNLM OT - accelerometry OT - apnoea OT - infant OT - mannequin OT - simulation OT - wearable electronic device COIS- S.R. is the founder of Goldilocks and supplied the Goldilocks Suit for research use and conducted blinded data analysis. EDAT- 2026/06/15 12:52 MHDA- 2026/08/17 17:45 PMCR- 2026/08/17 CRDT- 2026/06/15 08:44 PHST- 2026/05/05 00:00 [revised] PHST- 2025/12/22 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/08/17 17:45 [medline] PHST- 2026/06/15 12:52 [pubmed] PHST- 2026/06/15 08:44 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - JPC70471 [pii] AID - 10.1111/jpc.70471 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Aug;62(8):1509-1519. doi: 10.1111/jpc.70471. Epub 2026 Jun 15. PMID- 42294390 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 1662-5153 (Print) IS - 1662-5153 (Electronic) IS - 1662-5153 (Linking) VI - 20 DP - 2026 TI - Physical activity, sedentary behavior, and cognitive function in children and adolescents: a scoping review of dose-response relationships, screen time interactions, and public health implications. PG - 1848119 LID - 10.3389/fnbeh.2026.1848119 [doi] LID - 1848119 AB - BACKGROUND: Physical inactivity among children and adolescents has reached critical levels worldwide, with approximately 81% of school-aged youth failing to meet the World Health Organization recommendation of at least 60 min of moderate-to-vigorous physical activity per day. At the same time, screen-based sedentary behaviors have increased substantially, raising concerns about their combined impact on brain development, cognitive processes, and behavioral regulation. Although extensive research exists, evidence regarding dose-response relationships, neurobiological mechanisms, and the moderating role of screen-related behaviors remains fragmented. OBJECTIVES: This scoping review aimed to systematically map the evidence linking physical activity and sedentary behavior with cognitive outcomes in children and adolescents, examine dose-response patterns, synthesize underlying neurobiological mechanisms (including brain-derived neurotrophic factor and neuroplasticity), and evaluate the moderating influence of screen time and smartphone-related behaviors. METHODS: The review followed PRISMA-ScR guidelines and the Joanna Briggs Institute methodology. Six electronic databases (PubMed/MEDLINE, Scopus, Web of Science, SPORTDiscus, PsycINFO, and CINAHL) were searched for studies published between January 2000 and March 2026. Eligibility criteria were defined using the Population-Concept-Context framework. Two independent reviewers conducted screening, achieving strong inter-rater reliability (kappa = 0.84). RESULTS: Of 2,843 records identified, 60 studies met inclusion criteria across four thematic domains: physical activity and cognitive outcomes, dose-response parameters, neurobiological mechanisms, and screen-based sedentary behavior including nomophobia. Chronic physical activity, particularly in school-based and clinical ADHD settings, was consistently associated with executive function improvements across included systematic reviews and trials. Screen time exceeding 4 h per day was associated with anxiety, depressive symptoms, and attentional deficits in observational data. Evidence on exercise-induced BDNF upregulation, contingent on structured exposure (>/=3 sessions/week, >/=12 weeks), is restricted to five pediatric RCTs and warrants cautious interpretation. CONCLUSION: This scoping review maps consistent associations between physical activity and improved cognitive function in youth, mediated through neurobiological pathways that vary in strength across study designs and populations. Excessive screen exposure is associated with cognitive risk in observational data. Integrated public health frameworks addressing physical activity, screen time, and sleep represent a priority direction for future longitudinal research and policy development. CI - Copyright (c) 2026 Dergaa, Dhahbi, Dergaa, Razzak, Ceylan, Stefanica, Muntean and Guelmami. FAU - Dergaa, Ismail AU - Dergaa I AD - Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba, Tunisia. AD - Research Unit of Physical Activity, Sport, and Health, UR18JS01, National Observatory on Sport, Tunis, Tunisia. AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Dhahbi, Wissem AU - Dhahbi W AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Dergaa, Mohamed Amine AU - Dergaa MA AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Razzak, Mortadha AU - Razzak M AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AD - Department of Physical Education and Sports Teaching, Faculty of Sport Sciences, Ataturk University, Erzurum, Turkiye. FAU - Stefanica, Valentina AU - Stefanica V AD - Department of Physical Education and Sport, Faculty of Sciences, Physical Education and Informatics, National University of Science and Technology Politehnica Bucharest, Pitesti University Center, Pitesti, Romania. FAU - Muntean, Raul Ioan AU - Muntean RI AD - Department of Physical Education and Sport, Faculty of Law and Social Sciences, University "1 Decembrie 1918" of Alba Iulia, Alba Iulia, Romania. FAU - Guelmami, Noomen AU - Guelmami N AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. LA - eng PT - Journal Article PT - Review DEP - 20260529 PL - Switzerland TA - Front Behav Neurosci JT - Frontiers in behavioral neuroscience JID - 101477952 PMC - PMC13260285 OTO - NOTNLM OT - BDNF OT - academic performance OT - brain development OT - children OT - cognitive function OT - dose-response OT - executive function OT - neuroplasticity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/05/29 CRDT- 2026/06/15 07:45 PHST- 2026/04/05 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:45 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.3389/fnbeh.2026.1848119 [doi] PST - epublish SO - Front Behav Neurosci. 2026 May 29;20:1848119. doi: 10.3389/fnbeh.2026.1848119. eCollection 2026. PMID- 42293961 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - The influence of adolescents' perceived task value in sport on exercise adherence: the chain mediating roles of general self-efficacy and action planning. PG - 1828334 LID - 10.3389/fpsyg.2026.1828334 [doi] LID - 1828334 AB - OBJECTIVE: This study examined the association between adolescents' perceived task value in sport and exercise adherence, as well as whether this association was explained by a serial mediation pathway through general self-efficacy and action planning. METHODS: A questionnaire-based cross-sectional survey was conducted from September 15 to December 15, 2025. Participants were 572 Chinese secondary-school students recruited from Tianjin, Guangxi, Hebei, and Liaoning. Measures assessed perceived task value in sport, general self-efficacy, action planning, and exercise adherence. Pearson correlations were computed, and a serial mediation model was tested using SPSS PROCESS (Model 6) with standardized coefficients and 5,000 bootstrap resamples to generate bias-corrected 95% confidence intervals (CIs). RESULTS: Perceived task value in sport was positively correlated with general self-efficacy (r = 0.184), action planning (r = 0.238), and exercise adherence (r = 0.372; all p < 0.001). General self-efficacy correlated with action planning (r = 0.324) and exercise adherence (r = 0.321), and action planning correlated with exercise adherence (r = 0.291) (all p < 0.001). Perceived task value predicted general self-efficacy (beta = 0.184, p < 0.001) and, with general self-efficacy, predicted action planning (beta = 0.185 and beta = 0.290, respectively; both p < 0.001). In the final model, all three predicted exercise adherence (beta = 0.296, beta = 0.218, and beta = 0.150, respectively; all p < 0.001). Bootstrap analyzes supported partial mediation: the total effect was beta = 0.372 (95% BootCI [0.296, 0.449]) and the direct effect remained significant at beta = 0.296 (95% BootCI [0.221, 0.372]). All indirect pathways were significant: the general self-efficacy path (0.040, 95% BootCI [0.019, 0.067]), the action planning path (0.028, 95% BootCI [0.010, 0.052]), and the serial path via general self-efficacy and action planning (0.008, 95% BootCI [0.003, 0.016]); the total indirect effect was 0.076 (95% BootCI [0.044, 0.114]). CONCLUSION: Adolescents who perceive higher task value in sport report stronger exercise adherence, both directly and indirectly through greater general self-efficacy and more concrete action planning. Interventions may enhance adherence by strengthening task value perceptions, building efficacy through mastery experiences and feedback, and training adolescents to formulate feasible action plans. CI - Copyright (c) 2026 Zhang, Wang, Zhou, Jing and Song. FAU - Zhang, Jingwen AU - Zhang J AD - School of Physical Education and Health, Guangxi Science and Technology Normal University, Laibin, Guangxi, China. AD - Keimyung University, Daegu, Republic of Korea. FAU - Wang, Zhenyu AU - Wang Z AD - Keimyung University, Daegu, Republic of Korea. FAU - Zhou, Yang AU - Zhou Y AD - School of Physical Education and Health, Guangxi Science and Technology Normal University, Laibin, Guangxi, China. FAU - Jing, Wen AU - Jing W AD - School of Physical Education, Bohai University, Liaoning, Liaoning, China. FAU - Song, Pengwei AU - Song P AD - School of Physical Education and Health, Guangxi Science and Technology Normal University, Laibin, Guangxi, China. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13253321 OTO - NOTNLM OT - action planning OT - adolescents OT - exercise adherence OT - general self-efficacy OT - perceived task value in sport COIS- The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 12:48 MHDA- 2026/06/15 12:49 PMCR- 2026/05/28 CRDT- 2026/06/15 07:42 PHST- 2026/03/11 00:00 [received] PHST- 2026/05/03 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/06/15 12:49 [medline] PHST- 2026/06/15 12:48 [pubmed] PHST- 2026/06/15 07:42 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1828334 [doi] PST - epublish SO - Front Psychol. 2026 May 28;17:1828334. doi: 10.3389/fpsyg.2026.1828334. eCollection 2026. PMID- 42293510 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2517-729X (Print) IS - 2517-729X (Electronic) IS - 2517-729X (Linking) VI - 39 IP - 3 DP - 2026 Jun TI - Exercise type, dose and mental health outcomes in youth: Which types and doses are sufficient? PG - e70031 LID - 10.1002/gps3.70031 [doi] LID - e70031 AB - BACKGROUND: Although experimental evidence supports links between exercise and certain mental health indicators, epidemiological research has focused primarily on the dose-response effect of a single type of exercise, overlooking potential differences across exercise types in their associations with overall and specific mental health outcomes. AIMS: To examine the associations between different types of exercise and multiple mental health outcomes, including depression, anxiety, post-traumatic stress disorder, suicidal ideation, suicide attempts and nonsuicidal self-injury, and to explore their dose-response relationships in terms of exercise frequency and duration. METHODS: Data were drawn from a large-scale, cross-sectional study of 79 011 university students in Jilin Province, China, in 2021 via an online survey. Mental health outcomes were evaluated using validated scales and diagnoses. Propensity score matching was first applied to balance covariates between exercise types. Logistic regression analysis was then used to examine the associations between exercise types and mental health outcomes. Additionally, generalised additive models were employed to explore the dose-response relationships between exercise frequency/duration and mental health outcomes, adjusting for sociodemographic factors. RESULTS: Among the 79 011 students reporting participation in physical exercise, team ball sports showed the strongest protective associations, followed by single anaerobic activities, two-player racket sports, single moderate-intensity aerobic sports and single low-intensity aerobic sports. U-shaped associations were observed between exercise frequency, duration and mental health outcomes. Exercising three to four times per week for 90-120 min was associated with a lower probability of reporting mental health problems, whereas excessive exercise was associated with poorer outcomes. CONCLUSION: Participation in different types of exercise is differentially associated with mental health outcomes, with team ball sports showing the most favourable associations. Optimal levels of exercise dosage vary between exercise types, suggesting that individuals may benefit from selecting exercise patterns that best support their mental health. CI - (c) 2026 The Author(s). General Psychiatry published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Mental Health Center. FAU - Wang, Huagen AU - Wang H AUID- ORCID: 0000-0002-1532-9365 AD - Department of Psychology, School of Humanities and Social Sciences Beijing Forestry University Beijing China. FAU - Aku, Yisheng AU - Aku Y AD - Vanke School of Public Health Tsinghua University Beijing China. AD - College of Athletic Training Chengdu Sports University Chengdu Sichuan China. FAU - Xu, Shicun AU - Xu S AD - Northeast Asian Research Center Jilin University Changchun Jilin China. AD - Department of Population, Resources and Environment, Northeast Asian Studies College Jilin University Changchun Jilin China. FAU - Ren, Zhanbing AU - Ren Z AD - College of Physical Education Shenzhen University Shenzhen Guangdong China. FAU - Zhang, Yingjie AU - Zhang Y AD - Tsinghua University Hospital Beijing China. FAU - Chen, Runsen AU - Chen R AUID- ORCID: 0000-0003-3398-5750 AD - Vanke School of Public Health Tsinghua University Beijing China. AD - Institute for Healthy China Tsinghua University Beijing China. FAU - An, Jing AU - An J AUID- ORCID: 0009-0005-6539-4981 AD - Beijing Huilongguan Hospital, Capital Medical University Beijing China. AD - Huilongguan Clinical Medical School Peking University Beijing China. AD - WHO Collaborating Center for Research and Training in Suicide Prevention Beijing China. LA - eng PT - Journal Article DEP - 20260612 PL - United States TA - Gen Psychiatr JT - General psychiatry JID - 101735271 PMC - PMC13261303 COIS- The authors declare no conflicts of interest. EDAT- 2026/06/15 12:53 MHDA- 2026/06/15 12:54 PMCR- 2026/06/12 CRDT- 2026/06/15 07:39 PHST- 2025/06/05 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/06/15 12:54 [medline] PHST- 2026/06/15 12:53 [pubmed] PHST- 2026/06/15 07:39 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - GPS370031 [pii] AID - 10.1002/gps3.70031 [doi] PST - ppublish SO - Gen Psychiatr. 2026 Jun;39(3):e70031. doi: 10.1002/gps3.70031. Epub 2026 Jun 12. PMID- 42293213 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Integrating health promotion into biology education: effects of classroom and extracurricular interventions in rural adolescents. PG - 1813900 LID - 10.3389/fnut.2026.1813900 [doi] LID - 1813900 AB - OBJECTIVE: Aim to explore the feasibility and preliminary impact of classroom-based and extracurricular interventions within eighth-grade biology curriculum to improve health promotion behavior (HPB) and multidimensional health of rural adolescents in China. METHODS: An exploratory study with two surveys was conducted at eighth-grade students in a Chinese rural middle school. The intervention combined theoretical classroom instruction with practical extracurricular activities, all embedded within the biology curriculum. Given the incomplete pairing of the two survey samples, the data were analyzed as independent samples. Statistical significance was assessed using the Chi-square test for categorical variables and the Mann-Whitney U test for continuous variables. RESULTS: Analyses indicated that the intervention was associated with significant positive outcomes. Compared with the first survey, the second had significantly higher overall HPB scores (p = 0.006, r = 0.155). Specifically, significant increases were observed in exercise behavior (p < 0.001, r = 0.231) and health responsibility (p = 0.004, r = 0.162). Additionally, the second survey group reported significantly better outcomes across multidimensional health, including self-reported health (p = 0.030, r = 0.121), physical health (p = 0.003, r = 0.167), and mental health (p = 0.009, r = 0.146). Subgroup analyses across both survey time points further revealed that the HPB-high group consistently scored significantly higher than the HPB-low group across all three health dimensions (all p < 0.001, r >/= 0.460). CONCLUSION: This exploratory study confirmed the feasibility of classroom-based and extracurricular intervention and its potential to improve adolescent health. The observed correlation between high HPB and better health outcomes only suggests an association and the need for targeted support. Our findings recommend a collaborative model in which educators and health professionals jointly develop and implement interventions to advance the holistic development of rural adolescents. CI - Copyright (c) 2026 Chen, Dang and Tian. FAU - Chen, Jie AU - Chen J AD - School of Marxism, Xinyang Normal University, Xinyang, Henan, China. FAU - Dang, Ruiping AU - Dang R AD - College of Life Science, Xinyang Normal University, Xinyang, Henan, China. FAU - Tian, Hua AU - Tian H AD - College of Tea and Food Science, Xinyang Normal University, Xinyang, Henan, China. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13253422 OTO - NOTNLM OT - biology teacher OT - health promotion behaviors OT - intervention OT - multidimensional health OT - rural school students OT - school nurses COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 12:53 MHDA- 2026/06/15 12:54 PMCR- 2026/05/28 CRDT- 2026/06/15 07:36 PHST- 2026/02/19 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/06/15 12:54 [medline] PHST- 2026/06/15 12:53 [pubmed] PHST- 2026/06/15 07:36 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.3389/fnut.2026.1813900 [doi] PST - epublish SO - Front Nutr. 2026 May 28;13:1813900. doi: 10.3389/fnut.2026.1813900. eCollection 2026. PMID- 42293103 OWN - NLM STAT- In-Process DCOM- 20260615 LR - 20260828 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 17 DP - 2026 TI - Highlighting the value of polymyography in childhood onset movement disorders. PG - 1771878 LID - 10.3389/fneur.2026.1771878 [doi] LID - 1771878 AB - INTRODUCTION: Characterizing hyperkinetic Movement Disorders (MD) in children is challenging, particularly when distinguishing tremor from myoclonus. Polymyography (EMG combined with accelerometry) and EEG jerk-locked back-averaging are well-established diagnostic tools in adults but are rarely applied in paediatric population. This study aimed to assess the feasibility and contribution of individualized neurophysiological investigations to the classification of hyperkinetic MD in children. MATERIALS AND METHODS: We retrospectively reviewed clinical and neurophysiological data from consecutive patients who underwent polymyography over a two-year period being referred for unclear clinical MD phenomenology. A pediatric MD specialist and a neurophysiologist jointly performed evaluations. RESULTS: 56/60 patients were included (four were excluded due to absent MD during recording or lack of cooperation). Myoclonus was the most frequent polymyography diagnosis (55%), followed by tremor (36%). Initial clinical diagnoses were confirmed in 62% of cases: all suspected cases of myoclonus were validated, whereas 48% patients initially diagnosed with tremor were reclassified as having myoclonus. Polymyography revealed additional MD in 18% of patients, most often myoclonus, and supported a neurofunctional aetiology in one case. After the polymyography, symptomatic pharmacological treatment-mainly for tremor and cortical myoclonus-was proposed in 34%. Additional genetic investigations were suggested in 30% of patients. DISCUSSION AND CONCLUSION: Polymyography proved feasible even in young children, including those with intellectual disability. Combined with expertise of an MD specialist, polymyography significantly improves diagnostic accuracy, particularly tremor vs. myoclonus, and guides both aetiologic and therapeutic management. These findings highlight the value of integrating polymyography into paediatric MD evaluation. CI - Copyright (c) 2026 Moretti, Ravelli, Ahmar, Dorison, De Salins, Rodriguez, Deiva, Vermersch, Triboulet, Valence, Harion, Burglen, Apartis and Doummar. FAU - Moretti, Raffaella AU - Moretti R AD - Department of Clinical Neurophysiology, Armand Trousseau Hospital, AP-HP-Sorbonne Universite, Paris, France. FAU - Ravelli, Claudia AU - Ravelli C AD - Department of Paediatric Neurology, Armand Trousseau Hospital, Referral Centre for Neurogenetic Rare Disease, APHP-Sorbonne Universite, Paris, France. FAU - Ahmar, Yara AU - Ahmar Y AD - Department of Clinical Neurophysiology, Saint-Antoine Hospital and Pitie-Salpetriere Hospital, APHP-Sorbonne Universite, Paris, France. FAU - Dorison, Nathalie AU - Dorison N AD - Unite Dyspa, Neurochirurgie Pediatrique, Hopital Fondation Rothschild, Paris, France. FAU - De Salins, Marie AU - De Salins M AD - Department of Clinical Neurophysiology, Armand Trousseau Hospital, AP-HP-Sorbonne Universite, Paris, France. FAU - Rodriguez, Diana AU - Rodriguez D AD - Department of Paediatric Neurology, Armand Trousseau Hospital, Referral Centre for Neurogenetic Rare Disease, APHP-Sorbonne Universite, Paris, France. AD - Sorbonne University, Paris, France. FAU - Deiva, Kumaran AU - Deiva K AD - Sorbonne University, Paris, France. AD - Department of Paediatric Neurology, Armand Trousseau Hospital, AP-HP Sorbonne University Hospital, Paris, France. FAU - Vermersch, Anne Isabelle AU - Vermersch AI AD - Department of Clinical Neurophysiology, Armand Trousseau Hospital, AP-HP-Sorbonne Universite, Paris, France. FAU - Triboulet, Minh Hanh AU - Triboulet MH AD - Department of Clinical Neurophysiology, Armand Trousseau Hospital, AP-HP-Sorbonne Universite, Paris, France. AD - Department of Paediatric Neurology, Armand Trousseau Hospital, AP-HP Sorbonne University Hospital, Paris, France. FAU - Valence, Stephanie AU - Valence S AD - Service de Neurologie Pediatrique, Hopital Armand Trousseau, AP-HP Sorbonne Universite, Paris, France. AD - Centre de Reference Maladies Rares "Deficience Intellectuelle de Cause Rare et Polyhandicap", Paris, France. FAU - Harion, Madeleine AU - Harion M AD - Service de Neurologie Pediatrique, Hopital Armand Trousseau, AP-HP Sorbonne Universite, Paris, France. AD - Centre de Reference Maladies Rares "Deficience Intellectuelle de Cause Rare et Polyhandicap", Paris, France. FAU - Burglen, Lydie AU - Burglen L AD - Sorbonne University, Paris, France. AD - Centre de Reference des Malformations et Maladies Congenitales du Cervelet et Laboratoire de Neurogenetique Pediatrique, Departement de genetique, Hopital Armand Trousseau, Paris, France. FAU - Apartis, Emmanuelle AU - Apartis E AD - Department of Clinical Neurophysiology, Saint-Antoine Hospital and Pitie-Salpetriere Hospital, APHP-Sorbonne Universite, Paris, France. AD - Paris Brain Institute, ICM, Inserm, CNRS, Sorbonne Universite, Paris, France. FAU - Doummar, Diane AU - Doummar D AD - Department of Paediatric Neurology, Armand Trousseau Hospital, Referral Centre for Neurogenetic Rare Disease, APHP-Sorbonne Universite, Paris, France. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC13253225 OTO - NOTNLM OT - childhood OT - dystonia OT - myoclonus OT - neurophysiology OT - paediatric movement disorders OT - polymyography OT - tremor COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor VL declared a past co-authorship with the authors CR and ND. EDAT- 2026/06/15 12:54 MHDA- 2026/06/15 12:55 PMCR- 2026/05/28 CRDT- 2026/06/15 07:35 PHST- 2025/12/19 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/06/15 12:55 [medline] PHST- 2026/06/15 12:54 [pubmed] PHST- 2026/06/15 07:35 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.3389/fneur.2026.1771878 [doi] PST - epublish SO - Front Neurol. 2026 May 28;17:1771878. doi: 10.3389/fneur.2026.1771878. eCollection 2026. PMID- 42292924 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2377-9608 (Electronic) IS - 2377-9608 (Linking) VI - 12 DP - 2026 Jan-Dec TI - Innovations in Pediatric Nursing: Emerging Technologies Including Virtual Reality, Telehealth, Artificial Intelligence, and Digital Mental Health-A Scoping Review. PG - 23779608261433684 LID - 10.1177/23779608261433684 [doi] LID - 23779608261433684 AB - BACKGROUND: Pediatric nursing is rapidly evolving with the integration of innovative technologies aimed at improving healthcare delivery and outcomes for children. OBJECTIVES: To map the extent and characteristics of pediatric nursing literature on (1) virtual reality (VR) for procedural care, (2) telehealth models, (3) artificial intelligence (AI)-supported diagnostics, (4) technology-enabled obesity interventions, and (5) digital mental-health tools; and to identify outcomes studied, populations/settings, study designs, and research gaps. METHODS: A scoping review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines was conducted. Peer-reviewed articles published from 2010 to 2024 were retrieved from PubMed, CINAHL, Scopus, Cochrane Library, and Google Scholar. Inclusion criteria were studies involving pediatric populations and addressing one of the specified technologies or interventions. RESULTS: Twenty-five studies were included. VR was effective in reducing procedural pain and anxiety. Telehealth improved care access, especially in underserved areas. AI-supported early diagnosis of diseases such as congenital heart defects. Nursing interventions for childhood obesity were most effective when multidisciplinary and personalized. Digital tools helped pediatric patients manage mental health conditions associated with chronic illness. However, gaps exist in long-term effectiveness, scalability, and integration. CONCLUSIONS: Emerging technologies in pediatric nursing offer substantial benefits but require further validation and structured implementation. Future research should focus on standardizing protocols, assessing cost-effectiveness, and addressing equity in access. CI - (c) The Author(s) 2026. FAU - Mohamed, Shimmaa Mansour Moustafa AU - Mohamed SMM AUID- ORCID: 0000-0002-2956-610X AD - Department of Nursing, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia. RINGGOLD: 488770 LA - eng PT - Journal Article PT - Review DEP - 20260612 PL - United States TA - SAGE Open Nurs JT - SAGE open nursing JID - 101724853 PMC - PMC13263502 OTO - NOTNLM OT - children OT - new graduate/graduate nurse OT - pediatrics OT - scoping review COIS- The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/06/12 CRDT- 2026/06/15 07:33 PHST- 2025/08/05 00:00 [received] PHST- 2026/02/27 00:00 [revised] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:33 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.1177_23779608261433684 [pii] AID - 10.1177/23779608261433684 [doi] PST - epublish SO - SAGE Open Nurs. 2026 Jun 12;12:23779608261433684. doi: 10.1177/23779608261433684. eCollection 2026 Jan-Dec. PMID- 42292890 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 18 DP - 2026 TI - Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. PG - 612886 LID - 10.2147/IJWH.S612886 [doi] LID - 612886 AB - This commentary examines gestational diabetes mellitus (GDM) as an under-recognised contributor to adverse maternal and neonatal outcomes among Somali women and in comparable fragile settings. GDM is associated with pre-eclampsia, macrosomia, obstructed labour, stillbirth, neonatal morbidity, and later type 2 diabetes in women and offspring. Globally, hyperglycaemia in pregnancy affects approximately one in six live births, yet detection and management remain least accessible in low-resource and conflict-affected settings. Somalia has high maternal and neonatal mortality, but local GDM prevalence data are not available and routine screening is rarely embedded in antenatal care. Drawing on WHO guidance, international evidence, and literature on Somali, East African, migrant, and humanitarian populations, we argue that GDM is made invisible by overlapping clinical, social, and health-system factors: early-life undernutrition, nutritional transition, high fertility, short birth intervals, limited antenatal access, weak diagnostic supply chains, low awareness of asymptomatic "sugar disease", and limited policy attention to pregnancy-related non-communicable diseases. These gaps convert a detectable and manageable condition into preventable complications, including obstructed labour, postpartum haemorrhage, hypertensive disorders, stillbirth, neonatal hypoglycaemia, and intergenerational diabetes risk. Practical responses include pragmatic risk-based or simplified glucose screening where oral glucose tolerance testing is not feasible, reliable access to glucometers and strips, midwife-led protocols, Somali-language education, engagement of families and community leaders while protecting women's autonomy, postpartum follow-up linked to immunisation and child-health contacts, and inclusion of GDM indicators in maternal health information systems. Recognising and addressing GDM is essential for reducing preventable maternal and neonatal harm and for strengthening equitable women's healthcare in fragile settings. CI - (c) 2026 Mudei et al. FAU - Mudei, Nasteho Mohamud AU - Mudei NM AUID- ORCID: 0009-0002-2744-9230 AD - Department of Obstetrics and Gynecology, Dr. Sumait Hospital, SIMAD University, Mogadishu, Banaadir, Somalia. FAU - Adawe, Mariam Mohamed Mohamud AU - Adawe MMM AD - Department of Obstetrics and Gynecology, Dr. Sumait Hospital, SIMAD University, Mogadishu, Banaadir, Somalia. FAU - Ali, Hamdi Abdi AU - Ali HA AD - Dr. Sumait Hospital, SIMAD University, Mogadishu, Banaadir, Somalia. FAU - Mohamud, Kadra Hassan AU - Mohamud KH AD - Department of Pediatrics, Dr. Sumait Hospital, SIMAD University, Mogadishu, Banaadir, Somalia. LA - eng PT - Journal Article DEP - 20260608 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC13263419 OTO - NOTNLM OT - antenatal care OT - fragile settings OT - gestational diabetes mellitus OT - maternal mortality OT - neonatal mortality OT - non-communicable diseases OT - postpartum follow-up COIS- The authors report no conflicts of interest in this work. EDAT- 2026/06/15 12:54 MHDA- 2026/06/15 12:55 PMCR- 2026/06/08 CRDT- 2026/06/15 07:32 PHST- 2026/03/29 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/15 12:55 [medline] PHST- 2026/06/15 12:54 [pubmed] PHST- 2026/06/15 07:32 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 612886 [pii] AID - 10.2147/IJWH.S612886 [doi] PST - epublish SO - Int J Womens Health. 2026 Jun 8;18:612886. doi: 10.2147/IJWH.S612886. eCollection 2026. PMID- 42292640 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 5 DP - 2026 May 31 TI - Combining bioinformatics and machine learning to identify common mechanisms and biomarkers of childhood asthma and obesity. PG - 182 LID - 10.21037/tp-2026-1-0108 [doi] LID - 182 AB - BACKGROUND: Childhood asthma (CA), a chronic inflammatory disorder of the airways, and childhood obesity (CO), characterized by low-grade systemic inflammation, frequently coexist. This study seeks to elucidate shared biological mechanisms underlying CA and CO and to identify potential biomarkers via comprehensive bioinformatics analyses of public datasets. METHODS: CA and CO gene expression datasets were retrieved from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) common to both conditions were identified, with hub genes (HGs) screened via four machine learning (ML) algorithms. The diagnostic performance of candidate HGs was evaluated utilizing receiver operating characteristic (ROC) curve analysis. Functional characterization was conducted utilizing Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and single-gene gene set enrichment analysis (GSEA). In addition, competitive endogenous RNA (ceRNA) networks were constructed to further explore regulatory relationships and shared pathogenic mechanisms. RESULTS: There were 25 key genes closely linked to CA and CO identified. Enrichment analyses indicated the main involvement of these genes in immune and inflammatory responses, as well as extracellular matrix organization and tissue remodeling. ML analyses ultimately identified NTRK2 and RGS1 as HGs, which demonstrated favorable diagnostic performance in ROC analyses. Furthermore, a ceRNA regulatory network comprising 104 long noncoding RNAs (lncRNAs), 80 microRNAs (miRNAs), and the two HGs was constructed. CONCLUSIONS: This study identified NTRK2 and RGS1 as key HGs shared between CA and CO, presenting fresh insights into their common pathogenic mechanisms. These findings possibly contribute to developing improved diagnostic biomarkers and targeted therapeutic strategies for CA comorbid with obesity. CI - (c) AME Publishing Company. FAU - Gou, Hao AU - Gou H AD - Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China. AD - Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhou, Hongyun AU - Zhou H AD - Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhao, Mengjie AU - Zhao M AD - Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhang, Xiaojin AU - Zhang X AD - Department of Library, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhao, Qiong AU - Zhao Q AD - Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China. AD - Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. LA - eng PT - Journal Article DEP - 20260424 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13263428 OTO - NOTNLM OT - Childhood asthma (CA) OT - bioinformatics OT - childhood obesity (CO) OT - machine learning (ML) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0108/coif). The authors have no conflicts of interest to declare. EDAT- 2026/06/15 12:48 MHDA- 2026/06/15 12:49 PMCR- 2026/05/31 CRDT- 2026/06/15 07:29 PHST- 2026/01/27 00:00 [received] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/06/15 12:49 [medline] PHST- 2026/06/15 12:48 [pubmed] PHST- 2026/06/15 07:29 [entrez] PHST- 2026/05/31 00:00 [pmc-release] AID - tp-15-05-182 [pii] AID - 10.21037/tp-2026-1-0108 [doi] PST - ppublish SO - Transl Pediatr. 2026 May 31;15(5):182. doi: 10.21037/tp-2026-1-0108. Epub 2026 Apr 24. PMID- 42291859 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - Caregiver Feeding Practices and Their Association With Nutritional Status in Children Aged 0-5 Years: A Descriptive Cross-Sectional Study From a Tertiary Care Center in North India. PG - e108756 LID - 10.7759/cureus.108756 [doi] LID - e108756 AB - Background Adequate nutrition in the first five years of life is critical for optimal physical growth, cognitive development, and long-term health outcomes. Caregiver feeding practices are an important factor associated with nutritional outcomes in young children with a spectrum of behaviors ranging from responsive feeding to more controlling strategies. While responsive feeding has been linked to better growth outcomes, the impact of specific feeding behaviors on child nutritional status in tertiary pediatric settings in North India remains poorly characterized. Therefore, this study aimed to evaluate caregiver feeding practices using a validated tool and examine their association with nutritional status in children aged 0-5 years. Objectives The objective of this study is to assess caregiver feeding practices using the Feeding Practices and Structure Questionnaire (FPSQ) and examine their association with nutritional status (Indian Academy of Pediatrics IAP grading) in children aged 0-5 years attending the outpatient department of a tertiary care pediatric center, in order to identify feeding behaviors associated with malnutrition in this setting. Materials and methods A descriptive cross-sectional study was carried out over a period of three months in the outpatient department of pediatrics at Christian Medical College, Ludhiana. A total of 150 caregivers of children aged 0-5 years were enrolled. After obtaining informed consent, each caregiver was administered a structured questionnaire (Feeding Practices and Structure Questionnaire FPSQ), which is a validated tool assessing both feeding practices and feeding patterns. Simultaneously, anthropometric measurements of the children were recorded, and their nutritional status was classified using the Indian Academy of Pediatrics (IAP) grading system. The collected data were analyzed to assess the association between feeding behavior and nutritional status. Results Out of 150 children, 83.3% were normally nourished, 16% had mild malnutrition, and 0.7% had moderate malnutrition. Responsive feeding behaviors such as feeding on demand and shared family meals were the most commonly reported practices. In the milk-feeding group, feeding on demand showed a significant association with better nutritional status (p = 0.015). In the semi-solid group, parent-led feeding was significantly associated with malnutrition (p = 0.008). Conclusion Feeding on demand was associated with better nutritional outcomes in milk-fed children, while parent-led feeding was associated with malnutrition in the semi-solid-feeding group. These findings are hypothesis-generating, given the cross-sectional design, and reverse causality cannot be excluded. Responsive feeding counseling may be a relevant avenue for nutritional improvement in routine pediatric outpatient care. CI - Copyright (c) 2026, John et al. FAU - John, Sharon R AU - John SR AD - Pediatrics and Child Health, Christian Medical College and Hospital, Ludhiana, Ludhiana, IND. FAU - Singh, Ruby AU - Singh R AD - Pediatrics and Child Health, Christian Medical College and Hospital, Ludhiana, Ludhiana, IND. LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13260016 OTO - NOTNLM OT - anthropometry OT - caregivers' influence OT - children OT - feeding pattern OT - malnutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. The Institutional Ethics Committee of Christian Medical College, Ludhiana, issued approval IECBMHR/202411-506/Apprvl-STS-Proj/CMC&H. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/05/12 CRDT- 2026/06/15 07:23 PHST- 2026/04/02 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:23 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.7759/cureus.108756 [doi] PST - epublish SO - Cureus. 2026 May 12;18(5):e108756. doi: 10.7759/cureus.108756. eCollection 2026 May. PMID- 42291790 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 19 DP - 2026 Sep TI - Development of program requirements for obesity medicine fellowship training in the U.S. PG - 100282 LID - 10.1016/j.obpill.2026.100282 [doi] LID - 100282 AB - BACKGROUND: Subspecialty fellowship training programs typically adhere to program requirements for graduate medical education for their field, which are established by accreditation organizations. However, US-based obesity medicine fellowships currently lack this guidance. Therefore, our objective was to develop and validate subspecialty fellowship program requirements for both adult and pediatric obesity medicine in the US. METHODS: A work group from the Obesity Medicine Fellowship Council (OMFC) was convened to define program requirements for obesity medicine (OM) fellowships, including standards for curricular and clinical experiences during training. Draft program requirements for adult OM and pediatric OM fellowships were developed through an iterative consensus group process with repeated cycles of drafting and revising by an expert work group who then gained input from the American Board of Obesity Medicine and leadership from all OMFC-recognized fellowship programs. The draft documents were subsequently revised and then validated through a national survey to all US-based OM fellowship programs, where adult OM fellowships evaluated the adult OM program requirements and pediatric OM fellowships evaluated the pediatric OM program requirements. Respondents were asked to 'approve'/'not approve' each proposed section with space for comments. An agreement of at least 75% among respondents was set as the threshold a priori for retaining a program requirement. RESULTS: Representatives from all adult and pediatric OM fellowship programs participated in the survey (n = 31). All items met the minimum threshold of >/=75% approving the requirement for both adult and pediatric OM fellowship programs. Comments for revisions on specific elements were primarily related to changes in language and formatting rather than conceptual underpinnings. CONCLUSION: A group consensus method strengthened by inclusion of a national survey of OM fellowship program directors resulted in carefully-developed and broadly-vetted program requirements. These OM fellowship program requirements offer educators and trainees a roadmap to develop comprehensive OM training. CI - (c) 2026 The Authors. FAU - Schmidt, Stacy L AU - Schmidt SL AD - Obesity Medicine Fellowship Council, Denver, CO, USA. FAU - Sabet, Amin AU - Sabet A AD - University of Massachusetts Chan Medical School, Worcester, MA, USA. FAU - Wong, Denise H AU - Wong DH AD - Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. FAU - Gilden, Adam H AU - Gilden AH AD - University of Colorado School of Medicine, Aurora, CO, USA. FAU - Wickham, Edmond P AU - Wickham EP AD - Virginia Commonwealth University School of Medicine, Richmond, VA, USA. FAU - Raatz, Sarah AU - Raatz S AD - University of Minnesota Medical School, Minneapolis, MN, USA. FAU - Fox, Claudia K AU - Fox CK AD - University of Minnesota Medical School, Minneapolis, MN, USA. FAU - Gudzune, Kimberly A AU - Gudzune KA AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. LA - eng PT - Journal Article DEP - 20260608 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13263674 OTO - NOTNLM OT - Clinical competence OT - Obesity management OT - Specialty boards COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Stacy Schmidt reports financial support was provided by Novo Nordisk Inc. Edmond P. Wickham 3rd reports a relationship with Novo Nordisk that includes: funding grants. Sarah Raatz reports a relationship with Novo Nordisk that includes: funding grants. Sarah Raatz reports a relationship with Eli Lilly and Company that includes: funding grants. Claudia K. Fox reports a relationship with Novo Nordisk Inc that includes: funding grants. Claudia K. Fox reports a relationship with Eli Lilly and Company that includes: funding grants. Amin Sabet reports a relationship with Abbott Laboratories that includes: equity or stocks. Amin Sabet reports a relationship with AbbVie that includes: equity or stocks. Amin Sabet reports a relationship with Eli Lilly and Company that includes: equity or stocks. Amin Sabet reports a relationship with Johnson and Johnson that includes: equity or stocks. Amin Sabet reports a relationship with Merck & Co Inc that includes: equity or stocks. Amin Sabet reports a relationship with Novo Nordisk that includes: equity or stocks. Kimberly A. Gudzune reports a relationship with Novo Nordisk Inc that includes: consulting or advisory, funding grants, and travel reimbursement. Kimberly A. Gudzune reports a relationship with Eli Lilly and Company that includes: consulting or advisory and travel reimbursement. Kimberly A. Gudzune has patent with royalties paid to Johns Hopkins ACG System. Given his role as an editor for Obesity Pillars, Amin Sabet had no involvement in the peer review of this article and had no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to another journal editor. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/06/08 CRDT- 2026/06/15 07:22 PHST- 2026/05/06 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:22 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - S2667-3681(26)00038-0 [pii] AID - 100282 [pii] AID - 10.1016/j.obpill.2026.100282 [doi] PST - epublish SO - Obes Pillars. 2026 Jun 8;19:100282. doi: 10.1016/j.obpill.2026.100282. eCollection 2026 Sep. PMID- 42290922 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2673-6101 (Electronic) IS - 2673-6101 (Print) IS - 2673-6101 (Linking) VI - 7 DP - 2026 TI - An online program focusing on modifiable lifestyle and environmental interventions was associated with improved pediatric eczema symptoms: results from a retrospective observational study. PG - 1759379 LID - 10.3389/falgy.2026.1759379 [doi] LID - 1759379 AB - BACKGROUND: Pediatric eczema is a highly prevalent condition that often causes substantial suffering among affected children and their families. The goal of this study was to evaluate the effects of an integrative program for parents of children with eczema that simultaneously addressed multiple modifiable lifestyle and environmental risk factors. METHODS: Children with eczema diagnosis who began the online eczema program and provided outcomes data from May 2024 to May 2025 were eligible. The primary outcome was the Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD), a validated measure of eczema symptoms and burden. Outcomes were assessed at baseline and at one month, two months, and six months after beginning the program. Changes in mean PO-SCORAD scores from baseline throughout the duration of the study were assessed with analysis of variance (ANOVA). Multivariate linear regression modeling of PO-SCORAD scores using population-averaged generalized estimating equations (GEE) were also constructed accounting for baseline PO-SCORAD scores and adjusting for age, sex, presence of any allergy, use of topical corticosteroids, and use of antihistamines. RESULTS: 197 participants were included in the study. The mean baseline PO-SCORAD score was 51.4, which is considered severe eczema. PO-SCORAD scores improved over the course of the study (p < 0.0001) and there were statistically significant and clinically meaningful improvements noted after one month (11.3 points, 22.0% improvement), two months (17.8 points, 34.6% improvement), and six months (27.2 points, 52.9% improvement) in the program (p < 0.0001). After accounting for baseline PO-SCORAD scores and covariates in regression modeling, there was a 22.5-point (p < 0.0001) improvement in PO-SCORAD scores from baseline to final assessment. There was a 31.4-point decrease in PO-SCORAD scores from baseline to final assessment (p < 0.0001, 47.2% improvement) among the subgroup of participants with severe eczema symptoms at baseline. CONCLUSIONS: An online program focusing on modifiable lifestyle and environmental modifications was associated with clinically meaningful symptom improvements among children with eczema. Symptoms improved relatively quickly and the greatest improvements were noted among children with severe symptoms at baseline. Further prospective studies will help generate more conclusive evidence of the causal effects of multimodal intervention focused on modifiable lifestyle factors and environmental exposures on pediatric eczema symptoms. CI - (c) 2026 Temple, Golden, Temple and D'Adamo. FAU - Temple, Ana-Maria AU - Temple AM AD - Integrative Health Carolinas, Charlotte, NC, United States. FAU - Golden, Desta AU - Golden D AD - Global Integrative Health Institute, Charlotte, NC, United States. FAU - Temple, John D AU - Temple JD AD - Integrative Health Carolinas, Charlotte, NC, United States. FAU - D'Adamo, Christopher R AU - D'Adamo CR AD - OvationLab, Richmond, VA, United States. AD - Documenting Hope, Windsor, CT, United States. AD - Department of Family and Community Medicine, University of Maryland School of Medicine, Baltimore, MD, United States. LA - eng SI - figshare/10.6084/m9.figshare.30647390 PT - Journal Article DEP - 20260529 PL - Switzerland TA - Front Allergy JT - Frontiers in allergy JID - 9918227355906676 PMC - PMC13260383 OTO - NOTNLM OT - eczema OT - environmental toxins OT - functional medicine OT - integrative medicine OT - microbiome OT - nutrition OT - pediatric OT - stress COIS- AMT and JT are owners of Integrative Health Courses. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 12:51 MHDA- 2026/06/15 12:52 PMCR- 2026/05/29 CRDT- 2026/06/15 07:16 PHST- 2025/12/02 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/06/15 12:52 [medline] PHST- 2026/06/15 12:51 [pubmed] PHST- 2026/06/15 07:16 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.3389/falgy.2026.1759379 [doi] PST - epublish SO - Front Allergy. 2026 May 29;7:1759379. doi: 10.3389/falgy.2026.1759379. eCollection 2026. PMID- 42290744 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Translation, cross-cultural adaptation and preliminary application of the premature infant oral motor intervention in Chinese neonatal nursing practice: a pilot randomized controlled trial. PG - 1784065 LID - 10.3389/fped.2026.1784065 [doi] LID - 1784065 AB - BACKGROUND: Oral motor intervention plays a critical role in facilitating nutritional intake and supporting neurodevelopmental outcomes in preterm infants. The Premature Infant Oral Motor Intervention (PIOMI) is a standardized, five-minute, eight-step manual protocol designed to enhance oral-motor skills and sucking performance in very preterm infants. AIM: To translate, culturally adapt, and preliminarily validate the PIOMI for neonatal nurses in mainland China, and to pilot-test its clinical feasibility and preliminary efficacy on oral sucking performance in very-preterm infants. DESIGN: This study employed a two-phase translation and testing approach. Phase 1 comprised Brislin's six-step translation, a two-round electronic Delphi (e-Delphi) process, and assessment of content validity and implementation consistency. Phase 2 involved a parallel-group pilot randomized controlled trial. METHODS: This study cross-culturally adapted the Premature Infant Oral Motor Intervention (PIOMI) into Chinese using Brislin's framework, finalized the mainland Chinese version (CMV-PIOMI) via a two-round e-Delphi expert consensus (n = 21), assessed its implementation consistency (n = 117), and evaluated its efficacy on preterm infants' oral sucking ability through a randomized controlled trial (n = 76). RESULTS: The Delphi response rate was 85.71% (n = 18), I-CVI ranged from 0.88 to 1.00, and S-CVI/Ave was 0.96, with six amendments incorporated. Among the 117 NICU nurses, the Pearson correlation coefficient for implementation consistency was 0.68 (p < 0.001), and paired CMV-PIOMI operational scores did not differ systematically (27.95 +/- 0.48 vs. 27.99 +/- 0.45, p = 0.266). In the pilot RCT (n = 76), baseline characteristics were comparable, and the proportion of preterm infants with normal sucking patterns was higher in the intervention group (50.0%) than in the control group (21.1%) (95% CI: 7.0% to 47.2%; p = 0.008). CONCLUSIONS: The Chinese PIOMI shows satisfactory content validity and acceptable implementation consistency and is feasible for delivery by bedside nurses. Preliminary evidence suggests improved oral sucking performance in very preterm infants, but larger, fully powered multicenter trials are needed to confirm these initial findings.Clinical Trial Registration: Chinese Clinical Trial Registry (ChiCTR) ID: ChiCTR2300070320. CI - (c) 2026 Wu, Chen, Fu, Ding, Wu, Yuan and Zhou. FAU - Wu, Nana AU - Wu N AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Chen, Xia AU - Chen X AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Fu, Jie AU - Fu J AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Ding, Liwen AU - Ding L AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Wu, Shuang AU - Wu S AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Yuan, Sushan AU - Yuan S AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Zhou, Hong AU - Zhou H AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. LA - eng PT - Journal Article DEP - 20260529 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13260545 OTO - NOTNLM OT - PIOMI OT - cross-cultural adaptation OT - e-Delphi OT - premature infants OT - translation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/05/29 CRDT- 2026/06/15 07:15 PHST- 2026/01/09 00:00 [received] PHST- 2026/03/23 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:15 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.3389/fped.2026.1784065 [doi] PST - epublish SO - Front Pediatr. 2026 May 29;14:1784065. doi: 10.3389/fped.2026.1784065. eCollection 2026. PMID- 42290410 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260918 IS - 1879-8365 (Electronic) IS - 0926-9630 (Linking) VI - 337 DP - 2026 Jun 15 TI - Side-Shift Therapy as Translation-Dominant 3D Auto-Correction in Adolescent Idiopathic Scoliosis: A Clinical-Mathematical Framework for Stratified PSSE. PG - 6-10 LID - 10.3233/SHTI260733 [doi] AB - Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity characterised by coronal curvature, axial rotation, and altered trunk translation. Radiographic indices (e.g., Cobb angle) quantify structure but incompletely represent functional correctability, a core target of physiotherapeutic scoliosis-specific exercises (PSSE). Side-Shift Therapy (SST), originating from the RNOH tradition (Mehta, 1985) and operationalised via a mobility classification (Betts et al., 2014), is a voluntary lateral translation of the trunk relative to the pelvis (not a side-bend). This paper presents a biomechanics-first teaching framework linking functional spinal unit (FSU) mechanics, thoracic ring behaviour, motor control sequencing, and growth-modulation hypotheses. FSUs are modelled as 6-DOF systems with translation-rotation coupling; in simplified terms, Ktt represents resistance to translation and Ktr represents how rotation changes when translation is performed (short note: coupling = rotation response during translation). Load-path optimisation is framed via an apical bending moment approximation M approximately Fg.dlat (dlat = lateral moment arm). Time-under-load is explained using viscoelastic forms where eta captures time-dependence. In growing spines, a Hueter-Volkmann-type simplification gdot = g0 - ksigma is used to describe stress-sensitive growth (k = stress sensitivity). Clinically, original mobility Types (1: beyond midline; 2: to midline; 3: cannot reach midline) are retained with reported substantial reliability (kappa approximately 0.76-0.77). A multiplanar update adds transverse modifiers for Types 1-2: A (rotation reduces), B (rotation persists), C (rotation worsens), providing a pragmatic proxy for coupling behaviour and thoracic compliance. The framework supports stratified PSSE prescription and outlines testable targets for reliability, responsiveness, and predictive validity. FAU - Betts, Tony AU - Betts T AD - Royal National Orthopaedic Hospital (RNOH), Stanmore, UK. CN - Scoliosis Interest Group (SIG) LA - eng PT - Journal Article PL - Netherlands TA - Stud Health Technol Inform JT - Studies in health technology and informatics JID - 9214582 SB - IM MH - *Scoliosis/physiopathology/therapy/rehabilitation MH - Humans MH - Adolescent MH - Biomechanical Phenomena MH - *Exercise Therapy/methods OTO - NOTNLM OT - PSSE OT - Side Shift Therapy EDAT- 2026/06/15 11:37 MHDA- 2026/06/15 12:49 CRDT- 2026/06/15 05:43 PHST- 2026/06/15 12:49 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/15 05:43 [entrez] AID - SHTI260733 [pii] AID - 10.3233/SHTI260733 [doi] PST - ppublish SO - Stud Health Technol Inform. 2026 Jun 15;337:6-10. doi: 10.3233/SHTI260733. PMID- 42290215 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261012 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) VI - 59 IP - 10 DP - 2026 Oct TI - Structural Validity of a Short Form of the Eating Disorder Examination Questionnaire in Adolescents Diagnosed With an Eating Disorder. PG - 2196-2206 LID - 10.1002/eat.70146 [doi] AB - OBJECTIVE: This study aimed to assess the structural validity and readability of a brief 7-item version of the Eating Disorder Examination Questionnaire (the EDE-Q7) among adolescents. METHOD: Latent variable analysis was used in a sample of 263 adolescents (age range = 13-17.99y) diagnosed with an eating disorder and recruited from treatment centres in the United States of America and Australia. Several indices were used to provide different estimates of overall model fit. RESULTS: The EDE-Q7 showed good fit to the data, although absolute fit indices suggested some evidence of imperfect fit. Several other models (both brief and full-item versions) failed to meet most criteria indicating good fit. The subscales of the EDE-Q7 showed significant correlations with several disordered eating behaviors, suggesting convergent validity. Review of the EDE-Q7 suggests ease of readability for adolescents from at least 11 years of age. DISCUSSION: This is one of the first clinical studies to support the EDE-Q7 as a brief, valid assessment of eating psychopathology that can be used with adolescents as well as adults. The results indicate that the EDE-Q7 might be appropriate for assessing eating pathology among adolescents from the age of 13 years. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Jenkins, Paul E AU - Jenkins PE AUID- ORCID: 0000-0003-1673-2903 AD - School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK. FAU - Gorrell, Sasha AU - Gorrell S AUID- ORCID: 0000-0002-8861-8547 AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA. FAU - Accurso, Erin C AU - Accurso EC AUID- ORCID: 0000-0002-5521-6381 AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA. AD - Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, San Francisco, California, USA. FAU - Eckhardt, Sarah AU - Eckhardt S AUID- ORCID: 0000-0003-0824-4328 AD - Center for the Treatment of Eating Disorders, Children's Minnesota, St Paul, Minnesota, USA. FAU - Hughes, Elizabeth K AU - Hughes EK AUID- ORCID: 0000-0002-4377-5610 AD - Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. AD - Murdoch Children's Research Institute, Parkville, Victoria, Australia. FAU - Le Grange, Daniel AU - Le Grange D AUID- ORCID: 0000-0001-7293-9496 AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA. FAU - Sawyer, Susan M AU - Sawyer SM AUID- ORCID: 0000-0002-9095-358X AD - Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. AD - Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Centre for Adolescent Health, Royal Children's Hospital, Parkville, Victoria, Australia. FAU - Rienecke, Renee D AU - Rienecke RD AUID- ORCID: 0000-0003-0423-7403 AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois, USA. LA - eng GR - Baker Foundation/ GR - Victorian Government's Operational Infrastructure Support Program/ GR - Goven Family Foundation/ PT - Journal Article PT - Validation Study DEP - 20260615 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Adolescent MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Surveys and Questionnaires/standards MH - Female MH - Reproducibility of Results MH - Psychometrics MH - Male MH - Australia OTO - NOTNLM OT - assessment OT - eating disorder examination-questionnaire OT - latent variable analysis OT - patient-reported outcome measures OT - psychometrics OT - readability EDAT- 2026/06/15 11:37 MHDA- 2026/10/12 11:41 CRDT- 2026/06/15 03:33 PHST- 2026/05/28 00:00 [revised] PHST- 2026/02/27 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/15 03:33 [entrez] AID - 10.1002/eat.70146 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Oct;59(10):2196-2206. doi: 10.1002/eat.70146. Epub 2026 Jun 15. PMID- 42290012 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2026 IP - 1 DP - 2026 TI - Accuracy and Reliability of Dental Age Estimation Methods in Iranian Children: A Systematic Review and Meta-Analysis. PG - e9351167 LID - 10.1155/bmri/9351167 [doi] LID - 9351167 AB - OBJECTIVES: This study is aimed at systematically evaluating the accuracy and reliability of dental age (DA) estimation methods and conducting a meta-analysis of studies on different DA estimation methods in Iranian children. METHODS: A systematic search of English and Persian literature from database inception to March 2024 was conducted across international and national databases to identify eligible studies on DA estimation using radiographs in Iranian children. Studies that used dental radiographs from healthy individuals aged 3-18 years and reported the mean difference (MD) between DA and chronological age (CA) were included. The meta-analysis calculated the MD between dental and chronological age, with 95% confidence intervals (CIs), to assess the applicability of the DA method for estimating CA in the Iranian population. RESULTS: Twenty-seven eligible published articles were included in this study. Demirjian's method overestimated age (overall MD: males: +0.784 years; females: +0.323 years). Among the alternative methods studied in the systematic review, Moorrees and Nolla's methods tended to underestimate age, whereas Cameriere, Smith, and London Atlas'methods tended to overestimate age. CONCLUSION: Most methods studied consistently overestimated age and should be used cautiously in forensic age estimation, underscoring the importance of tailoring methods such as the Demarjian method for the Iranian population to ensure accuracy and relevance in professional practice. Additional studies employing similar methodologies and focusing on the customization of dental age estimation methods are recommended to improve accuracy and applicability across diverse populations. CI - Copyright (c) 2026 Razieh Jabbarian et al. BioMed Research International published by John Wiley & Sons Ltd. FAU - Jabbarian, Razieh AU - Jabbarian R AUID- ORCID: 0000-0002-9142-8998 AD - Department of Pediatric Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. FAU - Ranjbaran, Mehdi AU - Ranjbaran M AUID- ORCID: 0000-0002-0313-3373 AD - Department of Epidemiology and Biostatistics, Non-Communicable Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. FAU - Mokhlesi, Aida AU - Mokhlesi A AUID- ORCID: 0000-0003-1612-1571 AD - Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. AD - USERN Office, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. AD - Student Research Committee, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. AD - Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran, usern.tums.ac.ir. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Child MH - Iran MH - Child, Preschool MH - Reproducibility of Results MH - Adolescent MH - Female MH - Male MH - *Tooth/diagnostic imaging PMC - PMC13265831 OTO - NOTNLM OT - Demirjian's method OT - Iranian children OT - chronological age OT - dental age estimation OT - meta-analysis OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/06/15 11:37 MHDA- 2026/06/15 11:38 PMCR- 2026/06/14 CRDT- 2026/06/15 01:53 PHST- 2026/02/08 00:00 [revised] PHST- 2024/07/29 00:00 [received] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/06/15 11:38 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/15 01:53 [entrez] PHST- 2026/06/14 00:00 [pmc-release] AID - BMRI9351167 [pii] AID - 10.1155/bmri/9351167 [doi] PST - ppublish SO - Biomed Res Int. 2026;2026(1):e9351167. doi: 10.1155/bmri/9351167. PMID- 42289808 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260824 IS - 1522-726X (Electronic) IS - 1522-1946 (Print) IS - 1522-1946 (Linking) VI - 108 IP - 2 DP - 2026 Aug TI - Percutaneous Deployment of the Sinus-SuperFlex-DS Stent for Hybrid Stage I Palliation in Neonates Weighing 60% VO(2) max) sessions. OSE performed table tennis; CSE did track-and-field. EF was assessed with SCWT, CFT, and TMT; visual perception used DTVP-3. Data were analyzed by two-way repeated-measures ANOVA, with ANCOVA used to adjust baseline differences. RESULTS: Compared with TD peers, ADHD + DD children exhibited impairments in inhibitory control (including Stroop A/B/C/D RT, Stroop B/D error count, and word interference time), all working memory indices, cognitive flexibility (digit-alphabet linking time), and all visual perception measures (all p < 0.05). After intervention the outcomes revealed significant Group x Time differences in EF, including inhibitory control (Stroop B/D RT, word interference time), working memory (delayed detail and structural memory), and cognitive flexibility (digit-alphabet linking time) (p < 0.05). Post-hoc tests confirmed that OSE yielded significantly greater improvements than CSE. For secondary visual perception outcomes, all measures showed significant Group x Time interactions (all p < 0.05). Further adjusted analyses demonstrated that OSE outperformed CSE significantly in visual-motor integration (VMI), copying ability, motor-reduced visual perception (MRP), form consistency, and general visual perception (GVP) (all p < 0.05). CONCLUSIONS: OSE (table tennis training) has superior efficacy in improving EF and visual perception in children with ADHD + DD compared with CSE (track-and-field training), providing preliminary empirical evidence for a feasible non-pharmacological intervention strategy for this population. CI - (c) 2026. The Author(s). FAU - Quan, Tianshen AU - Quan T AD - Physical Education School, Shenzhen University, Shenzhen, China. AD - Shenzhen Senior High School, Shenzhen, China. FAU - Ye, Jiefeng AU - Ye J AD - Physical Education School, Shenzhen University, Shenzhen, China. AD - Shenzhen Bao'an District Shangxing School, Shenzhen, China. FAU - Yu, Qian AU - Yu Q AD - Physical Education School, Shenzhen University, Shenzhen, China. FAU - Zhu, Feilong AU - Zhu F AD - Beijing Sport University, Beijing, China. FAU - Zhang, Lin AU - Zhang L AD - Physical Education School, Shenzhen University, Shenzhen, China. zhanglin0815@szu.edu.cn. LA - eng SI - ChiCTR/ChiCTR-2200065413, Registration time: 2022/11/04 GR - 32200942/the National Natural Science Foundation of China/ GR - 20220811090705001/Science, and the Technology and Innovation Commission of Shenzhen Municipality/ PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20260615 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Executive Function MH - *Attention Deficit Disorder with Hyperactivity/therapy/complications/psychology MH - *Dyslexia/therapy/complications/psychology MH - Child MH - Male MH - Female MH - *Exercise Therapy/methods MH - Treatment Outcome MH - Cognitive Flexibility PMC - PMC13501822 OTO - NOTNLM OT - ADHD + DD OT - Executive function OT - Motor-based intervention OT - Table tennis training program COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee and conducted in accordance with the Declaration of Helsinki. Chinese Clinical Trial Registry ( https://www.chictr.org.cn/indexEN.html ) (ChiCTR2200065413, Registration time: 2022/11/04). The research conforms with CONSORT guidelines. All participants provided written informed consent. Consent for publication: Written informed consent for publication was obtained from all participants. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:37 MHDA- 2026/08/24 05:34 PMCR- 2026/06/15 CRDT- 2026/06/14 23:27 PHST- 2025/10/23 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/24 05:34 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/14 23:27 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1186/s12887-026-07105-w [pii] AID - 7105 [pii] AID - 10.1186/s12887-026-07105-w [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 15;26(1):775. doi: 10.1186/s12887-026-07105-w. PMID- 42289524 OWN - NLM STAT- MEDLINE DCOM- 20260830 LR - 20260910 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 14 TI - Physical therapy using digital therapeutics in infants with congenital muscular torticollis: a pilot study. LID - 10.1038/s41598-026-56419-3 [doi] LID - 27129 AB - Congenital muscular torticollis (CMT) is a common musculoskeletal problem associated with unilateral sternocleidomastoid muscle stiffness. We evaluated the feasibility of the newly developed digital therapeutics (DTx) ACESO-APP, a personalized exercise app with real-time feedback, using skeleton-based motion analysis and artificial intelligence-driven body reconstruction models. Fourteen participants were randomized to undergo either weekly PT with standard home program education (SE group) or weekly PT with digital therapeutics lead home program (DTx group). A 12-week home exercise program (HEP) comprising stretching exercises was encouraged in both groups with weekly in-hospital PT. Clinical changes were assessed using the torticollis overall assessment at 4, 8, and 12 weeks, and participants' HEP adherence over 1 week was assessed using a questionnaire. Recruitment and completion rates, adherence rate, System Usability Scale scores, and adverse events were summarized using descriptive statistics. Eight participants (4 in each group) completed the study. The overall recruitment rate was approximately 5.2 participants per month, and the completion rate was 57.1% for both groups. The DTx group demonstrated higher adherence, with no reported adverse events. ACESO-APP demonstrated feasibility but achieved a suboptimal completion rate. These preliminary findings support large-scale trials and further optimization of HEP using the ACESO-APP in children with CMT. CI - (c) 2026. The Author(s). FAU - Lee, Chang Hee AU - Lee CH AD - Department of Rehabilitation Medicine, Myongji Hospital, 14-55 Hwasu-Ro, Deokyang-Gu, Goyang-Si, Gyeonggi-Do, 412-270, Republic of Korea. FAU - Seong, Jecheon AU - Seong J AD - Department of Rehabilitation Medicine, Myongji Hospital, 14-55 Hwasu-Ro, Deokyang-Gu, Goyang-Si, Gyeonggi-Do, 412-270, Republic of Korea. FAU - Lee, Yun Jee AU - Lee YJ AD - Department of Rehabilitation Medicine, Myongji Hospital, 14-55 Hwasu-Ro, Deokyang-Gu, Goyang-Si, Gyeonggi-Do, 412-270, Republic of Korea. FAU - Park, Dasom AU - Park D AD - Department of Rehabilitation Medicine, Myongji Hospital, 14-55 Hwasu-Ro, Deokyang-Gu, Goyang-Si, Gyeonggi-Do, 412-270, Republic of Korea. FAU - Kim, Aram AU - Kim A AD - Department of Rehabilitation Medicine, Myongji Hospital, Hanyang University College of Medicine, 14-55 Hwasu-Ro, Deokyang-Gu, Goyang-Si, Gyeonggi-Do, 412-270, Republic of Korea. akimrm0520@gmail.com. LA - eng GR - RS-2023-KH142023/SmartTech Clinical Research Center (SCRC)/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260614 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - Congenital torticollis SB - IM MH - Humans MH - *Torticollis/congenital/therapy MH - Pilot Projects MH - Female MH - Male MH - Infant MH - *Exercise Therapy/methods MH - *Physical Therapy Modalities MH - Mobile Applications MH - Digital Health PMC - PMC13526851 OTO - NOTNLM OT - Artificial intelligence OT - Congenital muscular torticollis OT - Digital therapeutics OT - Physical therapy COIS- Declarations. Competing interests: The authors declare no competing interests. Institutional review board: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of Myongji hospital (MJH 2023-07-007, 26/07/2023). Informed consent: Written informed consent was obtained from the parents or legal guardians of all the participants. EDAT- 2026/06/15 11:37 MHDA- 2026/08/31 19:42 PMCR- 2026/06/14 CRDT- 2026/06/14 23:21 PHST- 2025/04/29 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/08/31 19:42 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/14 23:21 [entrez] PHST- 2026/06/14 00:00 [pmc-release] AID - 10.1038/s41598-026-56419-3 [pii] AID - 56419 [pii] AID - 10.1038/s41598-026-56419-3 [doi] PST - epublish SO - Sci Rep. 2026 Jun 14;16(1):27129. doi: 10.1038/s41598-026-56419-3. PMID- 42288886 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261007 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jun 13 TI - Disordered eating in diet-treated inborn errors of metabolism: screening and behavioral insights. LID - 10.1186/s13023-026-04420-4 [doi] LID - 338 AB - BACKGROUND: Lifelong restrictive diets are a mainstay of management for many inborn errors of metabolism (IEMs). The experience of metabolic care providers suggests higher prevalence of disordered eating behaviors in this population; however, this has not been well characterized. In this study, we applied screening tools adapted to our population to identify eating disorders and characterize associated symptomatology. All participants were given 2 assessment tools: the SCOFF questionnaire, a 5-question screen for a possible eating disorder, and a modified Eating Pathology Symptoms Inventory (EPSI), a 45-item Likert-scaled questionnaire characterizing eating disorder pathology. Patients aged 16 years and older on prescription diets at the Program for Inherited Metabolic Diseases at the Icahn School of Medicine at Mount Sinai were recruited. Participant demographics were collected through medical record review. RESULTS: Fifty-two subjects were enrolled, and 51 completed both surveys. 27 subjects identified as female (52%), 23 as male (44%), and two as genderqueer (4%). Ages ranged from 16 to 50 years old. The most common diagnosis was phenylketonuria (n = 34, 65%), followed by glycogen storage disease type 1a (n = 8, 15%). Most patients were on a low-protein diet (n = 41, 79%), 17% (n = 9) were on a low-carbohydrate diet, and 6% (n = 3) were on a low-fat diet. The SCOFF screen positive rate was 34.6%, 95% CI [22.0% - 49.1%], which is significantly greater than population norms of 10.1% (p < 0.001). EPSI results revealed that our participants were significantly more likely to demonstrate binge eating, restrictive behaviors, excessive exercise, and negative attitudes towards obesity when compared to population norms. CONCLUSION: This study demonstrates a significantly increased screen positive rate of likely eating disorders among patients with IEM, about three times that of the general population. Metabolic providers should be aware of this potential risk to their patients, as eating disorders can impact metabolic control and adherence to diet, while also causing significant psychological distress to patients with these rare disorders. These results demonstrate that heightened awareness of potential eating disorders in patients with IEMs is warranted, and the development of validated screening tools may be impactful to their care and management. CI - (c) 2026. The Author(s). FAU - LoPiccolo, Mary Kate AU - LoPiccolo MK AUID- ORCID: 0009-0004-0851-3107 AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. mary.lopiccolo@mssm.edu. FAU - Cinnamon, Claire AU - Cinnamon C AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Donnelly, Colleen AU - Donnelly C AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Ginevic, Ilona AU - Ginevic I AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Waite, Jessica AU - Waite J AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Donnelly, Sara AU - Donnelly S AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Ma, Mingyu AU - Ma M AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Staccone, Caroline AU - Staccone C AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Estrella, Lissette AU - Estrella L AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Weinberg, Alan AU - Weinberg A AD - Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Hildebrandt, Thomas AU - Hildebrandt T AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Breilyn, Margo Sheck AU - Breilyn MS AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. LA - eng PT - Journal Article DEP - 20260613 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - Adolescent MH - *Feeding and Eating Disorders/diagnosis/etiology MH - Middle Aged MH - *Metabolism, Inborn Errors/diet therapy MH - Young Adult MH - Surveys and Questionnaires MH - Phenylketonurias/diet therapy PMC - PMC13637089 OTO - NOTNLM OT - Comorbidities OT - Eating disorder OT - Inborn errors of metabolism OT - Nutrition OT - Screening COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the declaration of Helsinki. Ethics and research governance approval were obtained from the Mount Sinai Institutional Review Board (IRB 21-01385). Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/06/15 11:29 MHDA- 2026/10/06 06:30 PMCR- 2026/06/13 CRDT- 2026/06/13 23:37 PHST- 2025/12/31 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/10/06 06:30 [medline] PHST- 2026/06/15 11:29 [pubmed] PHST- 2026/06/13 23:37 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s13023-026-04420-4 [pii] AID - 4420 [pii] AID - 10.1186/s13023-026-04420-4 [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jun 13;21(1):338. doi: 10.1186/s13023-026-04420-4. PMID- 42288871 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260908 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 13 TI - Fidelity evaluation of the Water First intervention for promoting tap water consumption in school-age children. LID - 10.1186/s12889-026-28101-w [doi] LID - 2399 AB - BACKGROUND: A cluster-randomized controlled trial examining the impact of the Water First water promotion and access program in 18 elementary schools found that the intervention increased water consumption and prevented overweight. This study describes a secondary analysis of implementation fidelity and its association with change in students' beverage intake and body mass index (BMI) z-score in the intervention arm. METHODS: Researchers observed Water First fidelity (visible water promotional material, quality of study-provided water sources and drinking vessels in classrooms, school cafeterias, high-traffic areas) 2 times/week during the intervention period, with data collected via yes/no questions. Responses indicating high fidelity were assigned a value of 1 and low fidelity were assigned 0; these were averaged to generate a summary score for each location (0 to 1). Home-engagement activity completion (%) was calculated per student based on returned class assignments. Anthropometrics and past-week frequency of beverage intake (instrument adapted from the validated Beverage and Snack Questionnaire) were assessed at baseline, 7-months, and 15-months. Mixed-effects linear regression models examined associations of fidelity with the primary (water intake) and secondary (sugar-sweetened beverage [SSB], milk, 100% fruit juice intake, BMI z-score) outcomes. The primary predictor was the fidelity score (0.1-unit increase) by time interaction. Beverage frequencies were log-transformed, and regression coefficients were exponentiated to derive the percent change in outcomes. RESULTS: Fidelity was highest in the cafeteria (mean: 0.87, SD: 0.06) compared to high-traffic water station areas (0.66, SD: 0.15) and classrooms (0.73, SD: 0.13). Mean home-engagement activity completion rate was 0.41 (SD: 0.33). There were no associations of fidelity with water intake. Each 0.1 unit increase in classroom fidelity was associated with a decreased intake of 100% fruit juice (0.95; Cl: 0.91-0.99). Higher high-traffic area fidelity was associated with decreased intake of SSB (0.94; Cl: 0.91-0.98) and plain milk (0.92; Cl: 0.89-0.96). Higher cafeteria fidelity was associated with 0.027 decrease in BMI z-score (Cl: -0.046, -0.008). No significant associations were observed for home-engagement activity completion. CONCLUSIONS: The intervention was largely implemented with high fidelity, with scores ranging from 0.66 to 0.87. Higher cafeteria fidelity was associated with reductions in BMI z-score, while home-engagement activity completion was not associated with changes in beverage outcomes or BMI z-score. TRIAL REGISTRATION: The trial was preregistered (2017-06-09) at clinicaltrials.gov (NCT03181971). CI - (c) 2026. The Author(s). FAU - Gupta, Anjali AU - Gupta A AD - Stanford University School of Medicine, Stanford, CA, USA. FAU - Ryu, Keejeong AU - Ryu K AD - Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, CA, USA. FAU - Peralta, Yadira AU - Peralta Y AD - Center for Research and Teaching in Economics, Department of Applied Economics, Aguascalientes, Mexico. FAU - Ordonez, Valeria AU - Ordonez V AD - Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA. FAU - McCulloch, Charles E AU - McCulloch CE AD - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. FAU - Schmidt, Laura A AU - Schmidt LA AD - Philip R. Lee Institute for Health Policy Studies and Department of Humanities and Social Sciences, University of California San Francisco, San Francisco, CA, USA. FAU - Ritchie, Lorrene D AU - Ritchie LD AD - Nutrition Policy Institute, Division of Agriculture and Natural Resources, University of California, Oakland, CA, USA. FAU - Patel, Anisha I AU - Patel AI AD - Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA. anipatel@stanford.edu. LA - eng SI - ClinicalTrials.gov/NCT03181971 GR - R01 HL129288/HL/NHLBI NIH HHS/United States GR - R01HL129288/National Heart, Lung, and Blood Institute of the National Institutes of Health/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260613 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Drinking Water) SB - IM MH - Humans MH - Child MH - Female MH - *Drinking Water MH - Male MH - *Health Promotion/methods MH - Beverages/statistics & numerical data MH - Body Mass Index MH - *Drinking MH - Schools MH - Program Evaluation MH - Overweight/prevention & control PMC - PMC13491641 OTO - NOTNLM OT - Beverages OT - Intervention fidelity OT - Obesity OT - Public health OT - Water COIS- Declarations. Ethics approval and consent to participate: This research was conducted in accordance with the Declaration of Helsinki. Signed informed parental consent and student assent were obtained for study participation. Institutional review boards at the University of California, San Francisco, and Stanford University approved study protocols. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:32 MHDA- 2026/08/20 05:43 PMCR- 2026/06/13 CRDT- 2026/06/13 23:37 PHST- 2025/02/27 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/08/20 05:43 [medline] PHST- 2026/06/15 11:32 [pubmed] PHST- 2026/06/13 23:37 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s12889-026-28101-w [pii] AID - 28101 [pii] AID - 10.1186/s12889-026-28101-w [doi] PST - epublish SO - BMC Public Health. 2026 Jun 13;26(1):2399. doi: 10.1186/s12889-026-28101-w. PMID- 42288850 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260822 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Jun 13 TI - Towards sustainable futures: development and validation of a Food Education Scale (FES) for upper elementary students in Taiwan. LID - 10.1186/s12966-026-01925-w [doi] LID - 77 AB - BACKGROUND: Food education has become an important policy priority in Taiwan following the enactment of the Food and Agriculture Education Act. However, empirically validated instruments for assessing food literacy among elementary school students remain limited. This study aimed to develop and validate a Food Education Scale (FES) for measuring food literacy among upper elementary school students in Taiwan. METHODS: The scale was developed based on the six principles of Taiwan's Food and Agriculture Education Act and Nutbeam's (2000) framework of functional, interactive, and critical literacy. A two-dimensional framework integrating food education content and literacy competencies was constructed. Through expert review, pilot testing, and large-scale survey administration, a 36-item questionnaire was finalized. The formal survey included 400 upper elementary students from 12 schools across northern, central, southern, and eastern Taiwan. Reliability and construct validity were assessed using Cronbach's alpha, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA) to demonstrate satisfactory construct, convergent, and discriminant validity. RESULTS: The results indicated that the FES demonstrated satisfactory psychometric properties. Internal consistency for all dimensions exceeded the recommended threshold (Cronbach's alpha > 0.70), and both EFA and CFA supported the scale's overall construct validity. In terms of performance patterns, students scored relatively higher in the dimensions related to cherishing food and reducing waste as well as food culture inheritance, while comparatively lower scores were observed in balanced dietary concepts and local production-local consumption. Differences in food literacy were also associated with school types, regional contexts, and family food practices. CONCLUSIONS: The Food Education Scale provides a validated instrument for assessing food literacy among upper elementary school students in Taiwan. The findings provide a validated, policy-aligned instrument for assessing children's food literacy and offer practical guidance for curriculum design and sustainability-oriented food education policies. CI - (c) 2026. The Author(s). FAU - Lai, Li-Jiuan AU - Lai LJ AD - Department of Environmental and Cultural Resources, National Tsing Hua University, No.101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan, R. O. C. FAU - Tseng, Tzuhui Angie AU - Tseng TA AD - Department of Environmental and Cultural Resources, National Tsing Hua University, No.101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan, R. O. C.. thtseng@mx.nthu.edu.tw. LA - eng PT - Journal Article PT - Validation Study DEP - 20260613 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Taiwan MH - Child MH - Female MH - Surveys and Questionnaires/standards MH - Male MH - *Students MH - Reproducibility of Results MH - Schools MH - Psychometrics MH - *Health Literacy MH - *Health Education/methods MH - Factor Analysis, Statistical PMC - PMC13491723 OTO - NOTNLM OT - Elementary school students OT - Food education OT - Food literacy OT - Scale development OT - Sustainability education COIS- Declarations. Ethics approval and consent to participate: The study was reviewed and approved by the Institutional Review Board of National Tsing Hua University, Taiwan (Approval No. 11204HT042), ensuring adherence to ethical standards. Consent for publication: All authors have read and approved the final version of this manuscript and consent to its publication in the journal. The authors confirm that the work has not been published previously and is not under consideration for publication elsewhere. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:32 MHDA- 2026/08/20 05:43 PMCR- 2026/06/13 CRDT- 2026/06/13 23:36 PHST- 2025/11/25 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/08/20 05:43 [medline] PHST- 2026/06/15 11:32 [pubmed] PHST- 2026/06/13 23:36 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s12966-026-01925-w [pii] AID - 1925 [pii] AID - 10.1186/s12966-026-01925-w [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Jun 13;23(1):77. doi: 10.1186/s12966-026-01925-w. PMID- 42288815 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 13 TI - Exploring the relationship between social media use, eating behaviors, and depression in young women: a machine learning-based cross-sectional study. LID - 10.1186/s12889-026-28138-x [doi] LID - 2247 AB - BACKGROUND: The increasing prevalence of social media use among young adults has raised concerns regarding its potential associations with mental health and eating behaviors. The aim of this study was to investigate the associations between social media use, eating behaviors, and depressive symptoms among young women and to evaluate the performance of machine learning algorithms in modeling these cross-sectional associations compared with conventional regression approaches. METHODS: A cross-sectional study was conducted among young women aged 18-34 years (n = 4,692) using a multi-site, face-to-face convenience sampling strategy. The survey collected data on BMI, patterns of social media use, the Beck Depression Inventory (BDI), and the Scale of Effects of Social Media on Eating Behavior (SESMEB). In addition to standard statistical analyses, various ML models, including Random Forest and Extreme Gradient Boosting (XGBoost), were applied to model SESMEB and BDI scores. Model performance was evaluated using internal validation procedures, including a train-test split and cross-validation, and assessed using root mean square error (RMSE) and mean absolute error (MAE). RESULTS: The mean age of participants was 23.8 years, and the mean BMI was 22.3 kg/m(2). Significant differences in BMI, SESMEB, and BDI scores were observed across social media platform use groups. Users of Facebook, TikTok, and Snapchat reported significantly lower SESMEB scores (p < 0.001). ML models identified BMI, snack intake, and social media use as influential variables associated with SESMEB and BDI scores. Random Forest showed the best modeling performance in the test set for both SESMEB and BDI scores, with XGBoost performing comparably. CONCLUSIONS: Social media use was associated with eating-related behaviors and depressive symptoms in young women. Within the study sample, ML models demonstrated modest modeling performance for SESMEB and BDI scores and may provide a complementary framework for examining complex associations among behavioral and psychological variables. However, these findings were based on internal validation only and require confirmation in independent external samples. Further research is warranted to clarify the direction of these associations, explore platform-specific differences, and evaluate the external validity of these models. CI - (c) 2026. The Author(s). FAU - Altan, Murat AU - Altan M AUID- ORCID: 0000-0002-9561-4755 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Firat University, Elazig, Turkiye. FAU - Kocaman, Semsi Gul Yilmaz AU - Kocaman SGY AUID- ORCID: 0000-0002-2825-7401 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Karamanoglu Mehmetbey University, Karaman, Turkiye. semsigul10@gmail.com. FAU - Ulger, Taha Gokmen AU - Ulger TG AUID- ORCID: 0000-0002-7751-9789 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Bolu Abant Izzet Baysal University, Bolu, Turkiye. FAU - Onal, Seda AU - Onal S AUID- ORCID: 0000-0002-8074-5584 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Firat University, Elazig, Turkiye. FAU - Yildirim, Hasan AU - Yildirim H AUID- ORCID: 0000-0003-4582-9018 AD - Department of Data Science and Analytics, Kamil Ozdag Faculty of Science, Karamanoglu Mehmetbey University, Karaman, Turkiye. LA - eng PT - Journal Article DEP - 20260613 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Social Media/statistics & numerical data MH - Young Adult MH - Adult MH - *Depression/epidemiology MH - Adolescent MH - *Feeding Behavior/psychology MH - *Machine Learning MH - Predictive Learning Models MH - Digital Media MH - Media Exposure PMC - PMC13420861 OTO - NOTNLM OT - Artificial intelligence OT - Beck Depression Inventory OT - Body mass index OT - Eating behavior OT - Machine learning OT - Social media COIS- Declarations. Ethics approval and consent to participate: All procedures involving human participants were conducted in accordance with the principles of the Declaration of Helsinki. To protect participant privacy, all names and identifying information were anonymised. Participation was voluntary, and written informed consent was obtained from all participants prior to data collection. No financial compensation was provided for participation. Ethical approval for the study was granted by the Scientific Research and Publication Ethics Committee of Social and Human Sciences, Karamanoglu Mehmetbey University (Decision No: 02-2024/38; approval date: 23/01/2024). The official ethics approval document has been provided as supplementary material for editorial verification (Additional File 1). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:31 MHDA- 2026/07/31 06:37 PMCR- 2026/06/13 CRDT- 2026/06/13 23:35 PHST- 2026/04/05 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/31 06:37 [medline] PHST- 2026/06/15 11:31 [pubmed] PHST- 2026/06/13 23:35 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s12889-026-28138-x [pii] AID - 28138 [pii] AID - 10.1186/s12889-026-28138-x [doi] PST - epublish SO - BMC Public Health. 2026 Jun 13;26(1):2247. doi: 10.1186/s12889-026-28138-x. PMID- 42288643 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261023 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 13 TI - Micronutrient intake and food insecurity among mothers of infants with orofacial clefts: a cross-sectional study in Iran. LID - 10.1038/s41598-026-57977-2 [doi] LID - 27066 AB - Cleft lip with or without cleft palate is a common congenital craniofacial anomaly influenced by genetic and environmental factors. This cross-sectional study investigated maternal micronutrient intake and household food insecurity among Iranian mothers of infants with orofacial clefts. Mothers of infants aged 0-12 months with cleft lip (CL), cleft palate (CP), or both were recruited from a referral hospital in Tehran (2019-2020). Dietary intake was assessed using a validated food frequency questionnaire, and food security was evaluated with a standardized instrument. Multinomial logistic regression was performed to examine associations. High prevalences of inadequate intake were observed for iron (91.0%), vitamin D (73.6%), vitamin A (70.6%), folate (60.2%), calcium (56.7%), and vitamin B6 (50.7%). Vitamin B12 inadequacy differed significantly across cleft types (p = 0.023), with higher prevalence in CP (35.8%) and CL/P (38.6%) compared with CL (19.2%). Food insecurity also differed significantly by cleft type (p = 0.024), with hunger reported in 42.9% of the CL/P, 24.5% of the CP, and 20.5% of the CL groups. In multinomial logistic regression (reference: CL), food insecurity without hunger was associated with lower odds of CL/P in the crude model (OR = 0.30, 95% CI: 0.14-0.65), although this association was attenuated after adjustment. However, a significant trend between increasing food insecurity and cleft severity persisted across all models (P-trend = 0.028). These findings highlight the importance of maternal nutrition and food security in preventive strategies. CI - (c) 2026. The Author(s). FAU - Kalantar-Hormozi, Abdoljalil AU - Kalantar-Hormozi A AD - Research and Development Center, 15 Khordad Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Hojaji, Elham AU - Hojaji E AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. elhamhojaji@gmail.com. FAU - Avani, Anita AU - Avani A AD - Research and Development Center, 15 Khordad Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. anita.41724@gmail.com. FAU - Alijani, Sepideh AU - Alijani S AD - Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. FAU - Abaj, Faezeh AU - Abaj F AD - Department of Nutrition, Dietetics and Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, Australia. AD - Victorian Heart Institute, Victoria Heart Hospital, Clayton, VIC, Australia. FAU - Ebrahimian, Setayesh AU - Ebrahimian S AD - Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. AD - Student research committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260613 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Micronutrients) SB - IM MH - Humans MH - *Cleft Palate/epidemiology MH - *Cleft Lip/epidemiology MH - Iran/epidemiology MH - Cross-Sectional Studies MH - Female MH - *Food Insecurity MH - *Micronutrients MH - *Mothers MH - Infant MH - Adult MH - Infant, Newborn PMC - PMC13522343 OTO - NOTNLM OT - Cleft lip OT - Cleft palate OT - Dietary intake OT - Food insecurity OT - Orofacial clefts COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:34 MHDA- 2026/08/28 11:46 PMCR- 2026/06/13 CRDT- 2026/06/13 23:19 PHST- 2026/03/30 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/06/15 11:34 [pubmed] PHST- 2026/06/13 23:19 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1038/s41598-026-57977-2 [pii] AID - 57977 [pii] AID - 10.1038/s41598-026-57977-2 [doi] PST - epublish SO - Sci Rep. 2026 Jun 13;16(1):27066. doi: 10.1038/s41598-026-57977-2. PMID- 42288024 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260810 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 161 DP - 2026 Oct TI - Psychometric properties of the paternal support scale for breastfeeding in the Iranian fathers population. PG - 104893 LID - S0266-6138(26)00197-X [pii] LID - 10.1016/j.midw.2026.104893 [doi] AB - PROBLEM: The support of fathers is a crucial factor for successful breastfeeding. However, there has been a lack of a validated tool to measure this in Iran, which has impeded targeted assessment and intervention. BACKGRUND: Breastfeeding provides essential health benefits for infants. Paternal support plays a significant role in its continuation, highlighting the importance of having a culturally adapted measurement instrument within the Iranian context. METHODS: This methodological study used a cross-sectional design and selected 460 Iranian fathers through multi‑stage cluster sampling (detailed in Methods). It examined the scale's face validity, content validity, construct validity, and reliability after translation and cultural adaptation. RESULTS: First, confirmatory factor analysis (CFA) on the original 21‑item unidimensional model showed poor fit (chi(2)/df = 10.95, CFI = 0.45, RMSEA = 0.20), indicating that the original structure was not appropriate for the Iranian population. Therefore, exploratory factor analysis (EFA) was conducted, following which two items were removed from the original 21-item Turkish scale. The final Persian version comprised 19 items loading on four dimensions: cooperation, empowerment, caring, and facilitation. EFA extracted these factors explaining 62.507% of the total variance, and Confirmatory Factor Analysis (CFA) confirmed the model's adequacy. The scale demonstrated strong internal consistency (Cronbach's alpha=0.89) and excellent test-retest reliability (ICC=0.95). DISCUSSION: The study has successfully culturally adapted the PSSB into Persian, resulting in a culturally relevant, multidimensional tool. The four identified dimensions capture the holistic nature of paternal support in breastfeeding, aligning with the Iranian family context. The strong psychometric properties confirm its robustness for application in similar urban, educated populations. CONCLUSION: In this sample of Iranian fathers from Ardabil, the Persian version of the Paternal Support Scale for Breastfeeding (PSSB) demonstrated strong psychometric properties. The 19‑item, four‑factor structure showed excellent internal consistency, test‑retest reliability, and convergent/discriminant validity. The scale shows promise for use in similar urban and educated populations, pending further validation in rural, less educated, and low‑income groups. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Dastafkan, Sakine AU - Dastafkan S AD - Pediatric Nursing Student, Department of Pediatric Nursing, School of Nursing and Midwifery, Ardabil University of Medical Science, Ardabil, Iran. Electronic address: sakinedastafkan409@gmail.com. FAU - Vosoghi, Nazila AU - Vosoghi N AD - Department of Pediatric Nursing, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address: Vosoghi2015@yahoo.com. FAU - Belil, Fatemeh Ebrahimi AU - Belil FE AD - Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address: sara.1381@yahoo.com. FAU - Shahmari, Mehraban AU - Shahmari M AD - Nursing, Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address: mehrabanshahmari@yahoo.com. LA - eng PT - Journal Article DEP - 20260607 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - *Psychometrics/instrumentation/methods/standards MH - Iran MH - *Breast Feeding/psychology/methods MH - Male MH - Reproducibility of Results MH - Adult MH - *Fathers/psychology MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Factor Analysis, Statistical MH - *Social Support OTO - NOTNLM OT - Breastfeeding OT - Paternal support OT - Psychometric properties OT - Scale COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/06/15 11:33 MHDA- 2026/08/11 00:35 CRDT- 2026/06/13 18:08 PHST- 2025/12/13 00:00 [received] PHST- 2026/05/03 00:00 [revised] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/08/11 00:35 [medline] PHST- 2026/06/15 11:33 [pubmed] PHST- 2026/06/13 18:08 [entrez] AID - S0266-6138(26)00197-X [pii] AID - 10.1016/j.midw.2026.104893 [doi] PST - ppublish SO - Midwifery. 2026 Oct;161:104893. doi: 10.1016/j.midw.2026.104893. Epub 2026 Jun 7. PMID- 42287854 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) VI - 22 IP - 5 DP - 2026 Oct TI - Stretched penile length in boys with hypospadias: Population-based analysis using validated nomogram. PG - 106058 LID - S1477-5131(26)00337-2 [pii] LID - 10.1016/j.jpurol.2026.106058 [doi] AB - BACKGROUND: Hypospadias affects 1 in 200-300 male births. Parents are often concerned about penile adequacy beyond the urethral defect itself, yet few studies have systematically compared stretched penile length (SPL) in hypospadias against population-based reference standards. OBJECTIVE: To evaluate SPL distribution patterns in boys with Types I and II hypospadias and compare them with established normative data. METHODS: The authors studied 876 consecutive boys aged 1-14 years with unoperated Types I (distal) and II (mid-shaft) hypospadias. Two observers independently measured SPL using the validated SPLINT technique. The SPL measurements were compared against age-matched normative data from 1276 Indian children. Exact binomial probability tests were used for percentile distributions, chi-square tests for subtype comparisons and t-tests for mean deviations. RESULTS: The cohort included 479 Type I and 397 Type II cases. SPL distribution showed a marked leftward shift: 71% fell below the 50th percentile (expected 50%, p < 0.001) and 41.5% below the 25th percentile. Lower percentiles were overrepresented, 20.7% were below the 10th percentile and 20.8% in the 10th-25th range. Upper percentiles were depleted: only 7.4% in the 75th-90th range and 1.7% above the 90th percentile (all p < 0.001). Mean SPL was reduced by 6.8% (95% CI: -8.18 to -5.42%) in Type I and 7.5% (95% CI: -9.05 to -5.92%) in Type II. The two subtypes showed no significant distributional difference (chi(2) = 6.22, p = 0.18), suggesting that meatal position does not predict SPL reduction. CONCLUSIONS: Boys with distal and mid-shaft hypospadias show clinically meaningful SPL reduction that follows a continuous distribution rather than an all-or-none pattern. SPL reduction appears independent of meatal position. These findings support routine SPL assessment using population-specific references and can guide preoperative counselling. CI - Copyright (c) 2026 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. FAU - Goel, Prabudh AU - Goel P AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: drprabudhgoel@gmail.com. FAU - Choudhury, Prativa AU - Choudhury P AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: prativachoudhury1998@gmail.com. FAU - Yadav, Devendra Kumar AU - Yadav DK AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: drdevendra@hotmail.com. FAU - Kaur, Punit AU - Kaur P AD - Department of Biophysics & All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: punitkaur@aiims.edu. FAU - Singh, Harpreet AU - Singh H AD - Indian Council of Medical Research, New Delhi, India. Electronic address: hsingh@bmi.icmr.org.in. FAU - Mani, Kalaivani AU - Mani K AD - Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: manikalaivani@gmail.com. FAU - Bajpai, Minu AU - Bajpai M AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: bajpai2b@gmail.com. FAU - Agarwala, Sandeep AU - Agarwala S AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: sandpagr@hotmail.com. LA - eng PT - Journal Article DEP - 20260603 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM MH - Humans MH - Male MH - *Hypospadias/surgery/pathology MH - *Penis/pathology MH - Child, Preschool MH - Infant MH - *Nomograms MH - Child MH - Adolescent MH - Reference Values MH - Organ Size MH - Retrospective Studies OTO - NOTNLM OT - Hypospadias OT - Nomogram OT - Pediatric Urology OT - Penile Anthropometry OT - SPLINT Technique OT - Stretched Penile Length EDAT- 2026/06/15 11:34 MHDA- 2026/09/01 05:41 CRDT- 2026/06/13 18:03 PHST- 2026/01/02 00:00 [received] PHST- 2026/05/25 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/09/01 05:41 [medline] PHST- 2026/06/15 11:34 [pubmed] PHST- 2026/06/13 18:03 [entrez] AID - S1477-5131(26)00337-2 [pii] AID - 10.1016/j.jpurol.2026.106058 [doi] PST - ppublish SO - J Pediatr Urol. 2026 Oct;22(5):106058. doi: 10.1016/j.jpurol.2026.106058. Epub 2026 Jun 3. PMID- 42287140 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1748-2631 (Electronic) IS - 1748-2623 (Print) IS - 1748-2623 (Linking) VI - 21 IP - 1 DP - 2026 Dec 31 TI - Physical activity, sleep, dietary habits, and screen time in Bogota's children post-pandemic lockdown: a mixed-methods study. PG - 2683936 LID - 10.1080/17482631.2026.2683936 [doi] LID - 2683936 AB - PURPOSE: This study explored how Bogota's children reconfigured their post-lockdown routines as part of their lived experience after returning to in-person activities. METHODS: A mixed-methods design was applied to capture behavioral patterns and their meanings. Quantitatively, 217 children aged 8-12 years attending pediatric clinics (Oct 2022-Sep 2023) completed validated questionnaires assessing physical activity, sleep, diet, and screen exposure. Qualitatively, semi-structured interviews were conducted with 15 children selected through purposive sampling to deepen insight into their daily routines and perceptions. Quantitative data were analyzed descriptively and by sex, while thematic analysis of interviews provided contextual interpretation. Integration occurred through a narrative weaving approach. RESULTS: Quantitative findings indicated moderate physical activity (66% met >/= 3 days/week), widespread sleep disturbances (49.7%), recreational screen use (median= 6 hours/day), and poor dietary intake (>90% consumed fewer than two vegetable servings daily). Narratives revealed that play was often replaced by structured adult-imposed activities, screen time served as both emotional refuge and behavioral reward, and sleep was self-managed through distractions such as eating or watching TV. Children viewed these habits as normal despite feelings of fatigue, frustration, and a longing for autonomy. CONCLUSION: Children's post-lockdown routines reflect adaptation rather than behavioral lapses, requiring interventions focus on emotional regulation, time balance, quality rest, and active play (not merely a return to pre-pandemic norms). FAU - Castrellon-Vergara, Shirley AU - Castrellon-Vergara S AUID- ORCID: 0009-0002-2359-9282 AD - Programa de Especializacion en Pediatria - Facultad de Medicina, Fundacion Universitaria Sanitas, Bogota D.C., Colombia. FAU - Rueda-Alfonso, Blanca Nathalia AU - Rueda-Alfonso BN AUID- ORCID: 0000-0003-1976-5495 AD - Programa de Especializacion en Pediatria - Facultad de Medicina, Fundacion Universitaria Sanitas, Bogota D.C., Colombia. FAU - Palacios-Ariza, Maria Alejandra AU - Palacios-Ariza MA AUID- ORCID: 0000-0002-9795-0285 AD - Unidad de Investigacion, Fundacion Universitaria Sanitas, Bogota D.C., Colombia. FAU - Guevara-Santamaria, Fabian Ricardo AU - Guevara-Santamaria FR AUID- ORCID: 0000-0003-0993-745X AD - Versania Primera Infancia, Grupo Keralty, Bogota, D.C., Colombia. LA - eng PT - Journal Article DEP - 20260613 PL - United States TA - Int J Qual Stud Health Well-being JT - International journal of qualitative studies on health and well-being JID - 101256506 SB - IM MH - Humans MH - Child MH - Female MH - *Screen Time MH - Male MH - *Sleep MH - *COVID-19/epidemiology MH - *Exercise MH - *Feeding Behavior MH - Colombia/epidemiology MH - *Diet MH - Surveys and Questionnaires MH - SARS-CoV-2 MH - *Quarantine/psychology MH - Sleep Duration MH - Qualitative Research PMC - PMC13267027 OTO - NOTNLM OT - COVID-19 OT - Child health OT - dietary habits OT - lifestyle OT - physical activity OT - screen time OT - sleep COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 11:31 MHDA- 2026/06/15 11:32 PMCR- 2026/06/13 CRDT- 2026/06/13 07:03 PHST- 2026/06/15 11:32 [medline] PHST- 2026/06/15 11:31 [pubmed] PHST- 2026/06/13 07:03 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 2683936 [pii] AID - 10.1080/17482631.2026.2683936 [doi] PST - ppublish SO - Int J Qual Stud Health Well-being. 2026 Dec 31;21(1):2683936. doi: 10.1080/17482631.2026.2683936. Epub 2026 Jun 13. PMID- 30000953 STAT- Publisher CTDT- 20260615 PB - National Institute of Child Health and Human Development DP - 2006 TI - Carrot. BTI - Drugs and Lactation Database (LactMed(R)) AB - Carrots (Daucus carota) contain alpha- and beta-carotene. A poultice of raw carrots applied to the breast has been used to treat uncomplicated breast engorgement during breastfeeding;[1,2] however, evidence of efficacy is lacking because engorgement tends to improve over time regardless of treatment.[3] Carrots and the closely related wild carrots have been used as galactogogues, but valid scientific evidence for this use is lacking.[4] In Angola and Malawi, women are advised to drink carrot juice as a galactogogue.[5] No scientifically valid clinical trials support the use of carrots as a galactogogue. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[6,7] Carotenoids (beta-carotene, lutein, lycopene, zeaxanthin) and carrot flavor are transmitted into breastmilk. Carrot intake can improve maternal and breastmilk beta-carotene and vitamin A status,[8,9] but excessive maternal intake of carrots can lead to a harmless, reversible discoloration of the breastfed infant's skin. Many women believe that infant crying and fussiness is related to abdominal pain linked to feeding, and had eliminated items, such as carrots, from their diet in an attempt to change infant behavior, although there is no good evidence to support this assumption.[10] Moderately good evidence supports that maternal intake of carrots during early breastfeeding will improve their infant's liking of carrots later in life.[11-13] LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Daucus carota subsp. Sativus OT - Carota OT - Carotte OT - Cenoura OT - Danggeun OT - Gajar OT - Gelbe Rube OT - Hongdangmu OT - Hu Luo Bo OT - Karotte OT - Mohre OT - Mohrrube OT - Ninjin OT - Zanahoria EDAT- 2026/06/15 00:00 CRDT- 2026/06/15 00:00 AID - NBK501893 [bookaccession] PMID- 30000951 STAT- Publisher CTDT- 20260615 PB - National Institute of Child Health and Human Development DP - 2006 TI - Astragalus. BTI - Drugs and Lactation Database (LactMed(R)) AB - Astragalus (Astragalus membranaceus) root contains numerous saponins and isoflavones. Astragalus is a purported galactogogue;[1] however, no scientifically valid clinical trials support this use, except in a study in which Astragalus was only one component of a mixture of herbs. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[2,3] No data exist on the excretion of any components of Astragalus into breastmilk or on the safety and efficacy of Astragalus in nursing mothers or infants. Astragalus is generally well tolerated, with mild gastrointestinal irritation and allergic reactions reported. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site. LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) EDAT- 2026/06/15 00:00 CRDT- 2026/06/15 00:00 AID - NBK501891 [bookaccession] PMID- 30000900 STAT- Publisher CTDT- 20260615 PB - National Institute of Child Health and Human Development DP - 2006 TI - Licorice. BTI - Drugs and Lactation Database (LactMed(R)) AB - Licorice (Glycyrrhiza glabra) root contains glycyrrhizin (also called glycyrrhizic acid or glycyrrhizinic acid) and a mixture of the potassium and calcium salts of glycyrrhizic acid. Glycyrrhizin is metabolized to the active glycyrrhetinic acid in the intestine. Deglycyrrhizinated licorice (DGL) has had glycyrrhizin removed. Licorice is a purported galactogogue, and is included in some Asian proprietary mixtures to increase milk supply;[1] however, no scientifically valid clinical trials support this use. In fact, licorice usually reduces serum prolactin,[2] which might decrease milk production in the early stages of lactation. Women taking licorice have experienced elevated blood pressure.[3] Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[4,5] Some mothers in Turkiye reportedly use licorice to improve the taste and quality of their milk.[6] Glycyrrhizin is detectable in the breastmilk of some women taking licorice, but studies measuring glycyrrhetinic acid have not been performed. Licorice has been used safely and effectively in combination with other herbs given to infants as a tea for the short-term treatment of colic.[7] However, two infants whose mothers had an excessive intake of an herbal tea that contained licorice had signs of anethole toxicity.[8] Because both of these papers reported on herbal mixtures, the effect(s) of licorice alone cannot be determined. Licorice and licorice extract are "generally recognized as safe" (GRAS) as foods by the U.S. Food and Drug Administration. Long-term, excessive use of licorice can cause hypertension, hypokalemia, and disturbances of adrenal hormones, and therefore should probably be avoided during nursing. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site. LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Glycyrrhiza OT - Licorice OT - Liquorice OT - Sinu-rite OT - Glycyrrhiza glabra OT - CCRIS 9463 OT - UNII-2788Z9758H OT - Licorice, Glycyrrhiza glabra, ext. OT - EINECS 283-895-2 EDAT- 2026/06/15 00:00 CRDT- 2026/06/15 00:00 AID - NBK501840 [bookaccession] PMID- 42286760 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260621 LR - 20260813 IS - 1753-2000 (Print) IS - 1753-2000 (Electronic) IS - 1753-2000 (Linking) VI - 20 IP - 1 DP - 2026 Jun 13 TI - Feasibility and acceptability of a multi-level school-based intervention for adolescent mental health in Nepal: a mixed-methods study. LID - 10.1186/s13034-026-01111-7 [doi] LID - 86 AB - BACKGROUND: Adolescence is a crucial developmental stage characterized by rapid biological, psychological, and social changes, that increase vulnerability to mental health issues. Nearly half of all mental health conditions have their onset during this period and are influenced by individual, family, and environmental factors. Schools play a key role in promoting mental well-being among adolescents due to their accessibility and reach. While school-based mental health prevention interventions have shown positive outcomes in high-income countries, evidence from low- and middle-income countries (LMICs) is limited. This study aimed to assess the feasibility and acceptability of Health Action in Schools for a Thriving Adolescent Generation (HASHTAG), a comprehensive school-based intervention for adolescents aged 13-16 years in Nepal. METHODS: A feasibility cluster-randomized controlled trial was conducted in four secondary schools in Morang district, Nepal. Adolescents completed surveys at baseline and at a 3-month follow-up to evaluate mental well-being, emotional and behavioral outcomes, social support, school climate, and functioning. The intervention comprised two components: Thriving Environment in Schools (TES), implemented over three months and Thriving Together (TT), delivered through six weekly sessions. Quantitative data were collected electronically and analyzed descriptively. Qualitative data were gathered through focus group discussions and in-depth interviews with adolescents, teachers, and facilitators to explore implementation experiences and were analyzed thematically. RESULTS: Both the TES and TT components were well received, with TT sessions achieving an average attendance rate exceeding 70%, and being delivered as planned by trained facilitators, indicating good acceptability and feasibility. Explanatory analysis suggested a positive trend in anxiety outcomes in the intervention group while, social support showed a modest increase. Other outcomes showed small, non-significant changes. Qualitative findings highlighted perceived benefits such as improvements in school cleanliness, staff-student relationships, bullying and discrimination reduction, and positive social and behavioral changes. Participants found breathing exercises, games, the workbook, and the 'feeling box' particularly helpful. Implementation challenges included limited space, logistical constraints, COVID-19 related disruptions, and session length. CONCLUSION: HASHTAG demonstrated feasibility and accessibility as a school-based intervention for adolescents in Nepal, with preliminary indications of potential benefits. Addressing identified implementation challenges will be important for optimizing delivery in future studies. A fully powered randomized controlled trial is warranted to evaluate effectiveness. CI - (c) 2026. The Author(s). FAU - Luitel, Nagendra Prasad AU - Luitel NP AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. nagendra.luitel@ki.se. AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. nagendra.luitel@ki.se. AD - Center for Global Mental Health Equity, Department of Psychiatry and Behavioural Health, The George Washington University, Washington, DC, USA. nagendra.luitel@ki.se. FAU - Pradhan, Indira AU - Pradhan I AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. FAU - Lamichhane, Bishnu AU - Lamichhane B AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. FAU - Dulal, Nishan AU - Dulal N AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. FAU - Melendez-Torres, G J AU - Melendez-Torres GJ AD - University of Exeter, Exeter, UK. FAU - Shi, Emily AU - Shi E AD - University of Illinois Chicago College of Medicine, Peoria, IL, USA. FAU - Dhillon, Malka AU - Dhillon M AD - Columbia University, Columbia, NY, USA. FAU - Gautam, Kamal AU - Gautam K AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. AD - Center for Global Mental Health Equity, Department of Psychiatry and Behavioural Health, The George Washington University, Washington, DC, USA. FAU - Skeen, Sarah AU - Skeen S AD - Department of Global Health, Institute for Life Course Health Research, Stellenbosch University, Cape Town, South Africa. AD - Mental Health, Alcohol, Substance useand Tobacco Research Unit, South African Medical Research Council, Cape Town, South Africa. FAU - Tomlinson, Mark AU - Tomlinson M AD - Department of Global Health, Institute for Life Course Health Research, Stellenbosch University, Cape Town, South Africa. AD - School of Nursing and Midwifery, Queens University, Belfast, UK. FAU - Jordans, Mark J D AU - Jordans MJD AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. AD - Health Service and Population Research Department, Centre for Global Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. LA - eng GR - MR/ S02400X/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20260613 PL - England TA - Child Adolesc Psychiatry Ment Health JT - Child and adolescent psychiatry and mental health JID - 101297974 PMC - PMC13282874 OTO - NOTNLM OT - Depression and anxiety OT - Mental health promotion OT - Nepal OT - School climate OT - School-based COIS- Declarations. Ethics approval and consent to participate: This study was carried out in accordance with the Declaration of Helsinki and was granted ethical approval by the Nepal Health Research Council (NHRC) (Registration number: 342/2020P). Prior to participating in the study, each participant provided written informed consent. Only individuals who willingly agreed to take part were included in the study. Caregivers provided written consent and adolescents provided written assent before the study commenced. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/13 06:39 MHDA- 2026/06/13 06:40 PMCR- 2026/06/13 CRDT- 2026/06/13 00:12 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/24 00:00 [accepted] PHST- 2026/06/13 06:40 [medline] PHST- 2026/06/13 06:39 [pubmed] PHST- 2026/06/13 00:12 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s13034-026-01111-7 [pii] AID - 1111 [pii] AID - 10.1186/s13034-026-01111-7 [doi] PST - epublish SO - Child Adolesc Psychiatry Ment Health. 2026 Jun 13;20(1):86. doi: 10.1186/s13034-026-01111-7. PMID- 42286537 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260821 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 13 TI - Household soybean processing, protein content, and caregiver acceptability of complementary porridges in rural Malawi. LID - 10.1186/s12889-026-28098-2 [doi] LID - 2395 AB - BACKGROUND: Child undernutrition remains a major public health challenge in Malawi, where inadequate dietary protein contributes to persistent stunting and poor child health outcomes. Soybean (Glycine max) is a locally cultivable and protein-rich crop with potential to strengthen complementary feeding in resource-constrained rural settings. However, the nutritional and practical effectiveness of soybean-based complementary foods depends on household-level processing methods and caregiver acceptability. METHODS: A community-based experimental study was conducted in Dowa District, Central Malawi, in July 2025. Four locally cultivated soybean varieties were subjected to five household-level processing methods: untreated (control), soaked, roasted, dehulled, and dehulled-and-roasted. Protein content was determined using the Kjeldahl method with triplicate laboratory analyses. Caregiver sensory evaluation was conducted among 60 caregivers attending under-five clinics using structured tasting sessions assessing aroma, flavour, texture, and overall acceptability on a 10-point Likert scale. Data were analyzed using Kruskal-Wallis H tests, Mann-Whitney U tests, repeated-measures ANOVA, and bootstrap resampling to estimate 95% confidence intervals. RESULTS: Measured protein content differed significantly across soybean processing methods (H = 12.68, df = 4, p = 0.013). Dehulled soybean flour demonstrated the highest measured protein content (21.26% +/- 0.12; 95% CI: 21.12-21.40), while soaked soybean flour demonstrated the lowest (11.85% +/- 0.11; 95% CI: 11.73-11.97). Caregiver sensory evaluation additionally differed significantly across processing methods (p < 0.05). Dehulled-and-roasted soybean porridge achieved the highest overall acceptability score (8.2 +/- 0.2), followed by dehulled soybean porridge (7.8 +/- 0.4). Integrated assessment demonstrated that dehulled and dehulled-and-roasted soybean processing methods produced the most favorable combined nutritional and caregiver acceptability outcomes. CONCLUSION: Household soybean processing methods substantially influence both measured protein content and caregiver sensory acceptability of soybean porridge in rural complementary feeding contexts. Dehulling, with or without roasting, represents a locally feasible household processing strategy with potential to strengthen soybean-based complementary feeding using existing agricultural resources. The findings highlight the importance of integrating nutritional quality with caregiver acceptability in the development of sustainable community-based child nutrition interventions in low-resource settings. CI - (c) 2026. The Author(s). FAU - Chilanga, Emmanuel AU - Chilanga E AD - Department of Geography, University of Livingstonia, Livingstonia, Malawi. echilanga@gmail.com. LA - eng PT - Journal Article DEP - 20260613 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Dietary Proteins) SB - IM MH - Humans MH - Malawi MH - *Rural Population/statistics & numerical data MH - *Glycine max/chemistry MH - Infant MH - *Caregivers/psychology/statistics & numerical data MH - Male MH - Female MH - *Dietary Proteins/analysis MH - Family Characteristics MH - *Food Handling/methods MH - Adult MH - *Infant Food MH - Child, Preschool MH - Infant Nutritional Physiological Phenomena PMC - PMC13488205 OTO - NOTNLM OT - Soybean processing OT - caregiver acceptability OT - child nutrition OT - community nutrition OT - complementary feeding OT - household food environments OT - protein content OT - rural Malawi COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and received ethical approval from the University of Livingstonia Research Ethics Committee, Malawi. Written informed consent was obtained from all participating caregivers prior to participation in the sensory evaluation sessions. Participants were informed about the study objectives, voluntary nature of participation, confidentiality procedures, and their right to withdraw from the study at any stage without consequence. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/13 06:37 MHDA- 2026/08/19 14:49 PMCR- 2026/06/13 CRDT- 2026/06/13 00:05 PHST- 2026/01/29 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/08/19 14:49 [medline] PHST- 2026/06/13 06:37 [pubmed] PHST- 2026/06/13 00:05 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s12889-026-28098-2 [pii] AID - 28098 [pii] AID - 10.1186/s12889-026-28098-2 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 13;26(1):2395. doi: 10.1186/s12889-026-28098-2. PMID- 42286440 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260925 IS - 2719-535X (Electronic) IS - 2719-6488 (Print) IS - 1428-345X (Linking) VI - 30 IP - 1 DP - 2026 Jan 1 TI - Comparative Performance of Machine Learning Models Using Food Intake Frequency Versus Vegetable Intake Data to Predict Problematic Mealtime Behaviour in Japanese Preschool Children. PG - 106-115 LID - 10.34763/jmotherandchild.20263001.d-25-00036 [doi] AB - BACKGROUND: Selective eating often leads to nutritional imbalance and mealtime stress, making early identification essential. OBJECTIVE: This study aimed to compare the predictive performance of machine learning (ML) models using two types of input data-namely, vegetable intake and food frequency questionnaire (FFQ) responses-to identify children with selective eating behaviour (cutoff score >/=1.59). MATERIAL AND METHODS: We analysed a cross-sectional dataset of 283 children aged 3-6 years using up to 8 predictors selected from 15 food-frequency items or 15 designated vegetables, along with age and sex. Selective eating behaviour was defined as a selective eating score of >/= 1.59. Eleven ML algorithms were trained and evaluated, resulting in 11,253 feature-model combinations. Model performance was assessed using 5-fold cross-validation based on accuracy, precision, recall, F1 score, and ROC-AUC. Permutation importance analysis was conducted to identify key predictive features. RESULTS: Among the 11 ML algorithms tested, vegetable intake-based L1 logistic regression showed the best performance (ROC-AUC = 0.717, accuracy = 0.647, precision = 0.722, recall = 0.659, F1 = 0.808). Permutation importance further identified tomato, green onion, and taro as key contributors in the vegetable intake-based L1 logistic regression model. In contrast, the FFQ-based Naive Bayes model showed relatively good discrimination (ROC-AUC = 0.619) despite moderate recall. CONCLUSION: Vegetable intake-based ML models were more effective than those using FFQ data in identifying children with selective eating behaviour. Detailed dietary assessment aids early detection. CI - (c) 2026 Naoki Sakane et al., published by Institute of Mother and Child. FAU - Sakane, Naoki AU - Sakane N AUID- ORCID: 0000-0002-2625-571X AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Kawaguchi, Yaeko AU - Kawaguchi Y AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Somei, Junichiro AU - Somei J AUID- ORCID: 0009-0007-0804-0831 AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Suganuma, Akiko AU - Suganuma A AUID- ORCID: 0000-0002-2005-5151 AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Domichi, Masayuki AU - Domichi M AUID- ORCID: 0000-0002-6157-8151 AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260608 PL - Poland TA - J Mother Child JT - Journal of mother and child JID - 101771247 RN - Japanese people SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Classification Algorithms MH - Cross-Sectional Studies MH - East Asian People/psychology/statistics & numerical data MH - *Feeding Behavior/psychology MH - Japan MH - *Machine Learning MH - *Meals/psychology MH - Predictive Learning Models MH - Surveys and Questionnaires/statistics & numerical data MH - *Vegetables MH - Prediction Algorithms PMC - PMC13263313 OTO - NOTNLM OT - food OT - machine learning OT - machine performance OT - mealtime behaviour OT - preschool children OT - vegetable COIS- Conflicts of interest The authors declare that there are no conflicts of interest. EDAT- 2026/06/13 00:40 MHDA- 2026/06/13 06:38 PMCR- 2026/06/08 CRDT- 2026/06/12 23:53 PHST- 2025/09/10 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/06/13 06:38 [medline] PHST- 2026/06/13 00:40 [pubmed] PHST- 2026/06/12 23:53 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - jmotherandchild.20263001.d-25-00036 [pii] AID - 10.34763/jmotherandchild.20263001.d-25-00036 [doi] PST - epublish SO - J Mother Child. 2026 Jun 8;30(1):106-115. doi: 10.34763/jmotherandchild.20263001.d-25-00036. eCollection 2026 Jan 1. PMID- 42286347 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260821 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jun 12 TI - Development and initial validation of the Mindful Eating Behaviour Scale for children and parents. LID - 10.1007/s40519-026-01881-1 [doi] LID - 75 AB - PURPOSE: This research aimed to address existing methodological limitations in research on mindful eating behaviours in children, to enhance future research in this area. This manuscript presents the development and the assessment of the validity and reliability of a Mindful Eating Behaviour Scale for children and parents across five studies. METHODS: Study 1 assessed the scale's content validity using ratings from experts in the field. Study 2 evaluated the internal consistency of the scales. Study 3 explored temporal stability using a test-retest design with a 2-week interval. Studies 4 and 5 examined the criterion-related validity of the scales. RESULTS: Study 1 demonstrated that the items reflected the definition of mindful eating behaviour and were suitable for children. Study 2 showed that the scale and the subscales, "sensory attention" and "non-judgemental awareness" demonstrated good internal consistency. Using exploratory factor analysis, the scale supported the presence of two factors, "sensory attention" and "non-judgemental awareness". Study 3 showed that the scale was a reliable measure over time. Studies 4 and 5 showed that the scales are suitable measures for mindful eating behaviour. The scales demonstrated correlations between mindfulness and other eating behaviours, but further research is required, as only limited associations were observed. CONCLUSIONS: The current research presents new psychometric scales for mindful eating in children. The studies show that the scale is valid and reliable. LEVEL OF EVIDENCE: No level of evidence: basic science. CI - (c) 2026. The Author(s). FAU - Dunsmore, Natasha AU - Dunsmore N AD - Department of Psychology, School of Health and Life Sciences, Birmingham City University, The Curzon Building, 4 Cardigan St, Birmingham, B4 7BD, UK. natasha.dunsmore@mail.bcu.ac.uk. FAU - Hussain, Misba AU - Hussain M AD - Department of Psychology, School of Health and Life Sciences, Birmingham City University, The Curzon Building, 4 Cardigan St, Birmingham, B4 7BD, UK. FAU - Giannou, Kyriaki AU - Giannou K AD - Department of Psychology, Faculty of Health and Life Sciences, De Montfort University, Leicester, UK. FAU - Mantzios, Michail AU - Mantzios M AD - Department of Psychology, School of Health and Life Sciences, Birmingham City University, The Curzon Building, 4 Cardigan St, Birmingham, B4 7BD, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20260612 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - *Mindfulness MH - Child MH - Reproducibility of Results MH - Psychometrics MH - *Parents/psychology MH - Female MH - Male MH - Surveys and Questionnaires MH - *Child Behavior/psychology PMC - PMC13486019 OTO - NOTNLM OT - Children OT - Children's eating behaviours OT - Eating behaviours OT - Mindful Eating Behaviour Scale OT - Mindful eating OT - Mindful eating behaviour COIS- Declarations. Ethical approval: Ethical approval was obtained by the host University's Ethical Committee corresponding ethical guidelines. Application approval number: Dunsmore/#13801/sub3/R(B)/2024/Dec/BLSS FAEC. Participants were presented with information sheets and consent forms, following specific instructions set in the guidelines of the British Psychological Society (BPS), where a designated consent page used checkboxes to allow participants to indicate that they have read and understood each statement and key aspects of the consent information before proceeding with the study. The BPS ethical guidelines were followed when collecting the research and specified the retention of data for 10 years in a secure institutional server, to which participants also provided consent. Consent to participate: Informed consent was obtained from all individual participants included in the study. Consent for publication: Informed consent was obtained from all individual participants to publish the findings of this research. Competing interests: The authors declare no competing interests. EDAT- 2026/06/13 00:39 MHDA- 2026/08/19 14:49 PMCR- 2026/06/12 CRDT- 2026/06/12 23:26 PHST- 2025/12/12 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/08/19 14:49 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 23:26 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.1007/s40519-026-01881-1 [pii] AID - 1881 [pii] AID - 10.1007/s40519-026-01881-1 [doi] PST - epublish SO - Eat Weight Disord. 2026 Jun 12;31(1):75. doi: 10.1007/s40519-026-01881-1. PMID- 42286317 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260831 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jun 13 TI - Development and validation of the Japanese version of Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised (SATAQ-4R) among Japanese adolescents. LID - 10.1007/s40519-026-01877-x [doi] LID - 76 AB - PURPOSE: Internalization of appearance ideals and sociocultural pressures contribute to body dissatisfaction and eating disorders. Japanese adolescents report high levels of body dissatisfaction despite relatively low body mass index compared to peers in other countries, highlighting potential cultural influences. However, the Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised (SATAQ-4R) has not been validated in Japan. This study aimed to develop a Japanese version of the SATAQ-4R and examine its psychometric properties among Japanese adolescents. METHODS: A nationwide population-based study was conducted in 2023 among 1,368 adolescents aged 11-17 years (girls: n = 694; boys: n = 674). Participants completed self-reported questionnaires. The factor structure of the SATAQ-4R was evaluated using exploratory and confirmatory factor analyses (EFA and CFA), internal consistency was assessed using Cronbach's alpha, and convergent validity was examined using eating-related measures. RESULTS: EFA suggested a five-factor 23-item structure for girls and a seven-factor 23-item structure for boys. CFA showed suboptimal fit for the female model and comparatively better fit for the male model. Most subscales showed acceptable internal consistency, although one female pressure-related subscale showed inadequate reliability. Correlations with external measures provided partial evidence of convergent validity, with associations varying by sex and subscale. CONCLUSION: These findings provide preliminary evidence for psychometric properties of the Japanese SATAQ-4R. However, suboptimal female model fit, inadequate reliability of one female subscale, and mixed convergent validity evidence indicate that the resulting Japanese models should be used with caution. LEVEL OF EVIDENCE: Level III, cross-sectional observational study. CI - (c) 2026. The Author(s). FAU - Saito, Takumi AU - Saito T AD - Center for Postgraduate Education and Training, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. AD - Department of Life Course Epidemiology, Integrated Center for Women's Health, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. FAU - Ishitsuka, Kazue AU - Ishitsuka K AD - Department of Life Course Epidemiology, Integrated Center for Women's Health, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. ishitsuka-k@ncchd.go.jp. FAU - Piedvache, Aurelie AU - Piedvache A AD - Department of Social Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. FAU - Yamaguchi, Satoshi AU - Yamaguchi S AD - Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. FAU - Yamasaki, Syudo AU - Yamasaki S AD - Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. FAU - Usami, Satoshi AU - Usami S AD - Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. FAU - Ishiguro, Akira AU - Ishiguro A AD - Department of Pediatrics, National Disaster Medical Center, 3256 Midoricho, Tachikawa, Tokyo, 190-0014, Japan. FAU - Morisaki, Naho AU - Morisaki N AD - Department of Social Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. LA - eng GR - 23K12759/Japan Society for the Promotion of Science/ GR - 22H03362/Japan Society for the Promotion of Science/ GR - JPCA24DA1234/Children and Families Agency Program/ GR - 2023B-13/The Grant of National Center for Child Health and Development/ GR - 2025A-3/The Grant of National Center for Child Health and Development/ GR - JPJSJRP20211709/JRP-LEAD with UKRI/ GR - 23FB1003/Health Labour Sciences Research Grants/ PT - Journal Article PT - Validation Study DEP - 20260613 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 RN - Japanese people SB - IM MH - Humans MH - Male MH - Adolescent MH - Female MH - Japan MH - Psychometrics MH - Child MH - *Body Image/psychology MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Attitude MH - Factor Analysis, Statistical MH - Body Satisfaction MH - *Body Dissatisfaction/psychology MH - East Asian People PMC - PMC13518460 OTO - NOTNLM OT - Adolescents OT - Body image OT - SATAQ-4R OT - Social media OT - Thin internalization OT - Validation COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki and the Ethical Guidelines for Clinical/Epidemiological Studies of the Japanese Ministry of Health, Labour, and Welfare. Ethical approval was obtained from the Ethics Committee of the National Center for Child Health, Japan (No. 2021-133). Consent to participate: Written informed consent was obtained from the participants and their guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/13 00:40 MHDA- 2026/08/27 05:35 PMCR- 2026/06/13 CRDT- 2026/06/12 23:25 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/06/13 00:40 [pubmed] PHST- 2026/06/12 23:25 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1007/s40519-026-01877-x [pii] AID - 1877 [pii] AID - 10.1007/s40519-026-01877-x [doi] PST - epublish SO - Eat Weight Disord. 2026 Jun 13;31(1):76. doi: 10.1007/s40519-026-01877-x. PMID- 42285845 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260723 IS - 2212-1692 (Electronic) IS - 1875-9572 (Linking) VI - 67 IP - 4 DP - 2026 Jul TI - Pediatric post-acute sequelae of SARS-CoV-2 infection in Taiwan: Insights from the DISCOVER cohort. PG - 343-349 LID - S1875-9572(26)00072-0 [pii] LID - 10.1016/j.pedneo.2026.03.007 [doi] AB - The post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID, represent a multifaceted challenge in pediatric populations, characterized by symptoms persisting beyond the acute phase. In Taiwan, where early public health measures initially contained the pandemic, the 2022 Omicron surge prompted focused investigation into pediatric PASC, highlighting the critical need for longitudinal data in this specific demographic. To address this challenge, the Diagnosis and Support for COVID Children to Enhance Recovery (DISCOVER) study was established as a prospective, multidisciplinary cohort. By employing a multimodal approach, this study characterizes the clinical landscape of pediatric PASC in Taiwan through validated screening instruments, AI-driven diagnostics, and pulmonary assessments, while concurrently evaluating immune biomarkers, vaccination protection, and vitamin D intervention. This review synthesizes comprehensive findings from the cohort. While the acute phase of infection was predominantly mild, a substantial proportion of children experienced persistent multisystem symptoms, with fatigue, respiratory issues, and somatic complaints being most prevalent. Vaccination was found to significantly modify the disease trajectory, offering protection against subsequent gastrointestinal sequelae and preserving pulmonary function by mitigating small airway resistance. Furthermore, advanced diagnostic modalities, including impulse oscillometry and deep learning-assisted echocardiography, successfully unmasked subclinical organ dysfunction that conventional methods often failed to detect. Mechanistic investigations revealed that symptom severity was closely linked to elevated anti-nucleocapsid antibody titers, while markers of T-cell exhaustion evidenced persistent immune dysregulation, rather than ongoing viral replication. Notably, a preliminary single-center randomized controlled trial within this cohort provided early evidence that vitamin D supplementation may reduce the overall symptom burden and modulate pro-inflammatory cytokine profiles in children with PASC. Collectively, these findings underscore the multisystem nature and immune-driven mechanism of pediatric PASC, while highlighting the role of vaccination, advanced diagnostics, and targeted nutritional interventions in improving recovery. CLINICAL TRIAL REGISTRATION: NCT05426291 (ClinicalTrials.gov). CI - Copyright (c) 2026 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved. FAU - Chen, Pei-Chi AU - Chen PC AD - Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Hsu, Yu-Lung AU - Hsu YL AD - Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404327, Taiwan. FAU - Wu, Lawrence Shih-Hsin AU - Wu LS AD - Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404327, Taiwan. FAU - Liu, Xiao-Ling AU - Liu XL AD - Center of Allergy, Immunology and Microbiome (A.I.M), China Medical University Hospital and Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FAU - Tsai, Hui-Ju AU - Tsai HJ AD - Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan; Department of Medical Science, National Tsing-Hua University, Hsinchu, Taiwan. FAU - Wang, Jiu-Yao AU - Wang JY AD - Department of Pediatrics Allergy, Immunology, and Rheumatology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan; Center of Allergy, Immunology and Microbiome (A.I.M), China Medical University Hospital and Children's Hospital, China Medical University, Taichung, 404327, Taiwan; Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. Electronic address: a122@mail.ncku.edu.tw. CN - DISCOVER Study Group LA - eng SI - ClinicalTrials.gov/NCT05426291 PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20260529 PL - Singapore TA - Pediatr Neonatol JT - Pediatrics and neonatology JID - 101484755 SB - IM MH - Humans MH - Taiwan/epidemiology MH - *COVID-19/complications/diagnosis/epidemiology MH - Post-Acute COVID-19 Syndrome MH - Child MH - Cohort Studies MH - SARS-CoV-2 OTO - NOTNLM OT - COVID-19 OT - Pediatrics OT - Post-acute sequelae of SARS-CoV-2 infection (PASC) OT - Vitamin D COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. FIR - Wei, Gi-Hong IR - Wei GH IRAD- Division of Medical Research, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Liu, Pan-Yuan IR - Liu PY IRAD- Division of Medical Research, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Hsieh, Kai-Sheng IR - Hsieh KS IRAD- Department of Pediatric Cardiology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lai, Huan-Cheng IR - Lai HC IRAD- Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lin, Chien-Heng IR - Lin CH IRAD- Division of Pediatric Pulmonology and Intensive Care, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lin, Hsiao-Chuan IR - Lin HC IRAD- Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Chen, An-Chyi IR - Chen AC IRAD- Division of Pediatric Gastroenterology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lin, Hung-Chih IR - Lin HC IRAD- Division of Neonatology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Chou, I-Ching IR - Chou IC IRAD- Division of Pediatric Neurology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Soong, Wen-Jue IR - Soong WJ IRAD- Division of Pediatric Pulmonology and Intensive Care, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Hwang, Kao-Pin IR - Hwang KP IRAD- Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lu, Henry Horng-Shing IR - Lu HH IRAD- Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. FIR - Liu, Shu-Tsen IR - Liu ST IRAD- Department of Pediatric Psychiatry, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lin, Chung-Ying IR - Lin CY IRAD- Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan, 701401, Taiwan; School of Nursing, College of Nursing, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan. EDAT- 2026/06/13 00:39 MHDA- 2026/06/30 00:32 CRDT- 2026/06/12 21:58 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/02 00:00 [revised] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/06/30 00:32 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 21:58 [entrez] AID - S1875-9572(26)00072-0 [pii] AID - 10.1016/j.pedneo.2026.03.007 [doi] PST - ppublish SO - Pediatr Neonatol. 2026 Jul;67(4):343-349. doi: 10.1016/j.pedneo.2026.03.007. Epub 2026 May 29. PMID- 42285612 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Jun 12 TI - Smartphone-based support for early childhood development in a rural low-resource setting: an individually randomised pilot feasibility trial from Guatemala. LID - 10.1136/bmjpo-2025-003979 [doi] LID - e003979 AB - OBJECTIVE: To test the feasibility of a smartphone app, BebeApp, that provides evidence-based early childhood development (ECD) guidance in rural Guatemala and pilot procedures for an adequately powered randomised controlled trial. DESIGN: We conducted an individually randomised pilot feasibility trial to compare BebeApp to printed ECD guidance. SETTING: This trial was conducted in Tecpan, Chimaltenango, a semi-rural community that is 95% Kaqchikel Indigenous Maya. PATIENTS: First-time primary caregiver-infant (0-28 days) dyads. INTERVENTIONS: BebeApp provides age-dependent, evidence-based caregiver guidance for breastfeeding and complementary feeding, sleep and developmental support. MAIN OUTCOME MEASURES: A mixed-methods evaluation of BebeApp's implementation and acceptability using the Reach, Effectiveness, Adoption, Implementation, Maintenance framework. App usability, usefulness and satisfaction were assessed via questionnaires, semi-structured interviews and app interaction data. RESULTS: 41 infant-caregiver dyads were enrolled with 40 completing the study. Engagement was high with caregivers opening BebeApp a median (IQR) 11 (6-21) times per month. Usability was found to be acceptable but no difference was found between pre-measurements and post-measurements. In interviews, caregivers expressed some initial difficulty using BebeApp but were able to gain confidence with a training session. App usefulness and satisfaction responses were positive. Caregivers often noted that BebeApp was their only source of ECD information outside of their family. CONCLUSIONS: We found that caregivers in rural Guatemala responded positively to a smartphone ECD app and engaged with it throughout the trial. Given the urgent need for ECD programmes in low- and middle-income settings, smartphone apps may be a method to deliver services directly to caregivers. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Tschida, Scott AU - Tschida S AUID- ORCID: 0000-0002-1821-6702 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala scott.tschida@wuqukawoq.org. FAU - Tuiz, Eva Leticia AU - Tuiz EL AUID- ORCID: 0009-0005-4995-8273 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. FAU - Lopez, Duglas AU - Lopez D AUID- ORCID: 0009-0008-9117-3228 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. FAU - Canu, Meylin AU - Canu M AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. FAU - Boron, Vilma AU - Boron V AUID- ORCID: 0009-0003-2862-2848 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. FAU - Zarazua, Javier AU - Zarazua J AUID- ORCID: 0009-0008-8813-1529 AD - Proyecto Aigle Guatemala, Guatemala City, Guatemala Department, Guatemala. FAU - Grazioso, Maria Del Pilar AU - Grazioso MDP AD - Proyecto Aigle Guatemala, Guatemala City, Guatemala Department, Guatemala. FAU - Smith, Beth A AU - Smith BA AUID- ORCID: 0000-0003-2531-5394 AD - Developmental Neuroscience and Neurogenetics Program, Children's Hospital Los Angeles, The Saban Research Institute, Los Angeles, California, USA. AD - Division of Developmental-Behavioral Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA. AD - Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. FAU - Rohloff, Peter AU - Rohloff P AUID- ORCID: 0000-0001-7274-8315 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. AD - Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA. AD - Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260612 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Guatemala MH - Pilot Projects MH - *Smartphone MH - Infant MH - Feasibility Studies MH - Female MH - Male MH - Rural Population MH - *Child Development MH - *Mobile Applications MH - Infant, Newborn MH - Resource-Limited Settings MH - Breast Feeding MH - Caregivers/education PMC - PMC13289361 OTO - NOTNLM OT - Child Health OT - Information Technology OT - Low and Middle Income Countries OT - Qualitative research OT - Technology EDAT- 2026/06/13 00:39 MHDA- 2026/06/13 00:40 PMCR- 2026/06/12 CRDT- 2026/06/12 21:03 PHST- 2025/08/15 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/13 00:40 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 21:03 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003979 [pii] AID - bmjpo-2025-003979 [pii] AID - 10.1136/bmjpo-2025-003979 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Jun 12;10(1):e003979. doi: 10.1136/bmjpo-2025-003979. PMID- 42285572 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 12 TI - Association of 24-hour movement guideline adherence with mental health symptoms among Colombian university students: a cross-sectional study. PG - e118611 LID - 10.1136/bmjopen-2026-118611 [doi] LID - e118611 AB - OBJECTIVE: This study aimed to determine the associations between adherence to the 24-hour movement guidelines and symptoms of anxiety and depression among Colombian university students. STUDY DESIGN: Cross-sectional study. PARTICIPANTS: 1125 individuals (mean age 20.2+/-2.5 years; 56.7% female). SETTING: Students sampled from a single public university. PRIMARY AND SECONDARY OUTCOME MEASURES: Participants completed validated self-report instruments: the International Physical Activity Questionnaire-Short Form to assess physical activity (PA), sedentary behaviour (SB) and the Pittsburgh Sleep Quality Index to assess sleep duration. Symptoms of depression and anxiety were measured using the Hospital Anxiety and Depression Scale, with a score of >/=11 used to classify elevated symptoms. Binary logistic regression models were used to estimate associations between adherence to the 24-hour movement guidelines (meeting all three, two, one or none) and mental health outcomes, adjusting for potential confounders. RESULTS: Only 15.5% of students met all three components of the 24-hour movement guidelines. Meeting a greater number of components was significantly associated with lower odds of depressive and anxiety symptoms. In fully adjusted analyses, students who met all three guidelines were less likely to report anxiety symptoms (OR=0.26; 95%CI 0.13 to 0.54) and depressive symptoms (OR=0.42; 95%CI 0.22 to 0.79) compared with those who met none. Among individual behaviours, sufficient PA and adequate sleep were independently associated with lower odds of both outcomes, whereas high SB was associated with higher odds of elevated symptoms. CONCLUSIONS: In this cross-sectional study, adherence to a greater number of 24-hour movement guideline components was associated with lower levels of anxiety and depressive symptoms in a graded manner. However, the cross-sectional design precludes inference regarding directionality or causality, and bidirectional associations or residual confounding remain possible. Longitudinal and interventional studies are needed to determine whether integrated daily movement behaviours influence mental health outcomes in young adults, particularly in Latin American populations. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Romero-Martinez, Gonzalo AU - Romero-Martinez G AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Urriago-Fontal, Juan Carlos AU - Urriago-Fontal JC AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Quirama-Garcia, Hector Mario AU - Quirama-Garcia HM AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Ortiz-Lopez, Julian David AU - Ortiz-Lopez JD AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Arias-Alzate, Carolina AU - Arias-Alzate C AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Gutierrez-Quintero, Gustavo Adolfo AU - Gutierrez-Quintero GA AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Palma Pulido, Luis Hebert AU - Palma Pulido LH AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Calderon-Gonzalez, Juan Carlos AU - Calderon-Gonzalez JC AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Ramirez-Velez, Robinson AU - Ramirez-Velez R AUID- ORCID: 0000-0003-3075-6960 AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia robin640@hotmail.com robinson.ramirez@unavarra.es. AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Universidad Publica de Navarra (UPNA), Pamplona, Spain. AD - CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260612 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Colombia/epidemiology MH - Young Adult MH - *Students/psychology MH - *Depression/epidemiology/prevention & control MH - *Anxiety/epidemiology/prevention & control MH - Male MH - *Exercise/psychology MH - Universities MH - *Guideline Adherence MH - Sedentary Behavior MH - *Mental Health MH - Sleep Duration MH - Adult MH - Adolescent MH - Logistic Models MH - Surveys and Questionnaires MH - Self Report PMC - PMC13289006 OTO - NOTNLM OT - Anxiety disorders OT - Depression & mood disorders OT - Exercise OT - Health OT - SLEEP MEDICINE OT - Young Adult COIS- Competing interests: None declared. EDAT- 2026/06/13 00:38 MHDA- 2026/06/13 06:38 PMCR- 2026/06/12 CRDT- 2026/06/12 20:43 PHST- 2026/06/13 06:38 [medline] PHST- 2026/06/13 00:38 [pubmed] PHST- 2026/06/12 20:43 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - bmjopen-2026-118611 [pii] AID - 10.1136/bmjopen-2026-118611 [doi] PST - epublish SO - BMJ Open. 2026 Jun 12;16(6):e118611. doi: 10.1136/bmjopen-2026-118611. PMID- 42285221 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260929 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 75 DP - 2026 Oct TI - Nutritional intake in children with cerebral palsy and typically developing peers: A comprehensive study using a novel smartphone application. PG - 103401 LID - S2405-4577(26)00498-5 [pii] LID - 10.1016/j.clnesp.2026.103401 [doi] AB - BACKGROUND & AIMS: Nutrition might play a key role in addressing structural alterations in children with cerebral palsy (CP). However, a comprehensive description of their nutritional intake, and comparison to typically developing (TD) peers, using a low-burden assessment method, is lacking. The aim was to (1) propose a novel smartphone application to register nutritional intake; (2) comprehensively describe nutritional intake in children with CP in comparison to the nutritional guidelines; and (3) in comparison to TD peers. METHODS: A prospective cross-sectional observational study was conducted in ambulant children with spastic CP and TD peers. Nutritional intake was assessed using a 3-day estimated food record, logged in a novel smartphone application 'Digital Diary'. The intra-rater inter-session reliability of the Digital Diary was analyzed using the Intraclass Correlation Coefficient (ICC) and Standard Error of Measurements (SEM). The independent t-test investigated differences between the total samples of children with CP and TD children, and between the different age and CP-severity groups. RESULTS: Fifty-five children with spastic CP (6.51 +/- 3.10 years) and 50 TD children (7.26 +/- 2.85 years) were included. ICC varied from poor to good reliability, depending on the nutritional parameter. All children with CP and TD children met the daily protein intake guideline, but only half had a sufficient daily energy intake. This insufficient energy intake was not mirrored in their weight-for-height standard deviations. No significant differences (p > 0.05) exceeding the calculated SEM values were present between different CP-severity levels or between TD children and children with CP. CONCLUSIONS: The Digital Diary offers a time-efficient way to record nutritional intake. Although its test-retest reliability varied, key SEM values were reported to support more accurate interpretation. This study underscores the need to investigate the basal metabolic rate and overall energy requirements of children with CP in order to develop accurate, population-specific nutritional guidelines. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Verreydt, Ineke AU - Verreydt I AD - Department of Rehabilitation Sciences, KU Leuven, Belgium. Electronic address: ineke.verreydt@kuleuven.be. FAU - Rymen, Daisy AU - Rymen D AD - Department of Development and Regeneration, Faculty of Medicine, KU Leuven, Belgium. FAU - Staut, Lauraine AU - Staut L AD - Department of Rehabilitation Sciences, KU Leuven, Belgium; Clinical Motion Analysis Laboratory, University Hospitals Leuven, Belgium. FAU - Vanhauwaert, Erika AU - Vanhauwaert E AD - University Colleges Leuven-Limburg (UCLL), Centre of Expertise Health Innovation, Leuven, Belgium. FAU - Maes, Gitte AU - Maes G AD - Department of Rehabilitation Sciences, KU Leuven, Belgium. FAU - Lambrechts, Charlotte AU - Lambrechts C AD - Department of Rehabilitation Sciences, KU Leuven, Belgium. FAU - Campenhout, Anja Van AU - Campenhout AV AD - Department of Development and Regeneration, Faculty of Medicine, KU Leuven, Belgium; Pediatric Orthopedics, Department of Orthopedics, University Hospitals Leuven, Belgium. FAU - Desloovere, Kaat AU - Desloovere K AD - Department of Rehabilitation Sciences, KU Leuven, Belgium; Clinical Motion Analysis Laboratory, University Hospitals Leuven, Belgium. FAU - Ortibus, Els AU - Ortibus E AD - Department of Development and Regeneration, Faculty of Medicine, KU Leuven, Belgium; Leuven Child and Youth Institute, KU Leuven, Belgium. LA - eng PT - Journal Article PT - Observational Study DEP - 20260612 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Child MH - Female MH - Cross-Sectional Studies MH - *Smartphone MH - Prospective Studies MH - Male MH - Reproducibility of Results MH - Diet Records MH - *Mobile Applications MH - *Nutrition Assessment MH - Energy Intake MH - *Nutritional Status MH - Child, Preschool OTO - NOTNLM OT - Cerebral palsy OT - Dietary OT - Digital diary OT - Macronutrients OT - Nutrition OT - Typically developing COIS- Conflicts of interest The authors declare no conflict of interest. EDAT- 2026/06/13 00:38 MHDA- 2026/09/23 05:35 CRDT- 2026/06/12 19:32 PHST- 2026/01/27 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/23 05:35 [medline] PHST- 2026/06/13 00:38 [pubmed] PHST- 2026/06/12 19:32 [entrez] AID - S2405-4577(26)00498-5 [pii] AID - 10.1016/j.clnesp.2026.103401 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Oct;75:103401. doi: 10.1016/j.clnesp.2026.103401. Epub 2026 Jun 12. PMID- 42285031 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260810 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 161 DP - 2026 Oct TI - Strengthening breastfeeding with fatherly care: Transcultural validation of the Chinese version of the Paternal Support Scale for Breastfeeding (PSSB-C). PG - 104891 LID - S0266-6138(26)00195-6 [pii] LID - 10.1016/j.midw.2026.104891 [doi] AB - BACKGROUND: Fathers play a significant role in breastfeeding by providing emotional, informational, and practical support. However, few validated instruments assess fathers' self-perceived supportive behaviors. The Paternal Support Scale for Breastfeeding (PSSB) evaluates paternal support in breastfeeding settings. This study examines the reliability and validity of the Chinese version (PSSB-C) and explores links between paternal characteristics and support levels. METHODS: The PSSB was translated and adapted using an enhanced Brislin model. A convenience sample of 301 fathers was recruited from pediatric clinics in a tertiary hospital in Fujian, China. Participants completed a general questionnaire and the PSSB-C. The total sample was randomly split into two: Sample 1 (n = 151) for an Exploratory Factor Analysis (EFA) and Sample 2 (n = 150) for a Confirmatory Factor Analysis (CFA). Descriptive statistics, internal consistency, reliability, and regression of the PSSB-C scores were conducted using the total sample. The reliability of the instrument was verified using Cronbach's alpha and the intraclass correlation coefficient (ICC). RESULTS: The final PSSB-C comprised 18 items and had a one-factor structure. Internal consistency was high (Cronbach's alpha = 0.976; ICC = 0.813). The EFA accounted for 71.0% of the variance, and the CFA confirmed a good model fit with factor loadings ranged from 0.77 to 0.87. Item content validity index (I-CVI) ranging from 0.83 to 1.00. The PSSB-C scores were significantly different by father's age, infant's age, and place of residence (p < 0.05). CONCLUSIONS: The findings indicate that the 18-item PSSB-C reliably measures fathers' self-perceived supportive behaviors in breastfeeding. Using this scale in clinical settings can help identify fathers who provide inadequate support, guide personalized interventions, and encourage sustained breastfeeding, thereby improving health outcomes for mothers and infants. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Fu, Jie AU - Fu J AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China. Electronic address: fujie0628@163.com. FAU - Zhang, Kun AU - Zhang K AD - School of Nursing, Shanxi Medical University, Taiyuan 030001, China. Electronic address: 17860487212@163.com. FAU - Liu, Fangyi AU - Liu F AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China. Electronic address: fangyiliu2000@163.com. FAU - Zhang, Xueling AU - Zhang X AD - Department of Obstetrics and Gynecology Clinic, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China. Electronic address: zxl6120@163.com. FAU - Zeng, Yuxuan AU - Zeng Y AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China. Electronic address: zzzyyxx02@163.com. FAU - Qin, Yaling AU - Qin Y AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China. Electronic address: Yaling_Qin0202@163.com. FAU - Wang, Qiaosong AU - Wang Q AD - School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: WQS1765790647@163.com. FAU - Lin, Rongjin AU - Lin R AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China; Department of Nursing, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China. Electronic address: nplrj@126.com. LA - eng PT - Journal Article DEP - 20260607 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - *Breast Feeding/psychology/methods MH - Male MH - *Psychometrics/instrumentation/methods/standards MH - China MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Adult MH - *Fathers/psychology MH - Translating MH - Social Support OTO - NOTNLM OT - Breastfeeding OT - Paternal support OT - Psychometrics OT - Translation OT - Validation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/13 00:39 MHDA- 2026/08/11 00:35 CRDT- 2026/06/12 18:10 PHST- 2025/11/19 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/08/11 00:35 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 18:10 [entrez] AID - S0266-6138(26)00195-6 [pii] AID - 10.1016/j.midw.2026.104891 [doi] PST - ppublish SO - Midwifery. 2026 Oct;161:104891. doi: 10.1016/j.midw.2026.104891. Epub 2026 Jun 7. PMID- 42284873 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 1525-5069 (Electronic) IS - 1525-5050 (Linking) VI - 183 DP - 2026 Oct TI - Use of medium-chain triglycerides in paediatric patients with drug-resistant epilepsy without ketogenic therapy. PG - 111162 LID - S1525-5050(26)00283-0 [pii] LID - 10.1016/j.yebeh.2026.111162 [doi] AB - OBJECTIVE: This study aimed to evaluate the efficacy of a Medium Chain Triglyceride (MCT) add-on treatment in children with drug-resistant epilepsy (DRE). METHODS: We retrospectively reviewed 36 patients who received MCT add-on treatment using MCT oil (ratio C8:C10, 60:40) between June 2022 and May 2023 in our clinic. This treatment was proposed to patients before initiation of a ketogenic diet (KD), due to long waiting lists. After the completion of the MCT add-on phase patients were offered initiation of a KD. RESULTS: Overall, 66.7% of patients responded to MCT add-on treatment. The average MCT dose was 0.7 ml/kg body weight. Seizure reduction did not differ based on etiology, type of epilepsy, dietary intervention or type of feeding. No correlation was observed between seizure reduction and age at therapy, number of concomitant antiseizure medications or MCT dose. By contrast, treatment duration was positively correlated with response. After the MCT add-on phase 63.8% of patients decided to follow the proposed KD for at least 3 months. Of those, 65.2% experienced a further reduction in monthly seizures. SIGNIFICANCE: Our study shows that an MCT add-on treatment is feasible and effective in reducing seizures in paediatric patients with DRE, adding to existing evidence. Lower MCT doses might be beneficial to reduce the possibility of gastrointestinal side effects. The treatment may also serve as an introductory phase to KD, which in our cohort was associated with additional seizure reduction. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Viollaz, Rocio AU - Viollaz R AD - Ipensa Clinic, Ketogenic Therapy Team, La Plata, Argentina; Children's Hospital Sor Maria Ludovica, La Plata, Argentina; Germany's Hospital, Buenos Aires, Argentina. Electronic address: rviollaz@gmail.com. FAU - Alberti, Maria Julia AU - Alberti MJ AD - Ipensa Clinic, Ketogenic Therapy Team, La Plata, Argentina; Children's Hospital Sor Maria Ludovica, La Plata, Argentina. FAU - de Clauser, Larissa AU - de Clauser L AD - Dr. Schar AG, Winkelau 9, 39014 Postal, Italy. FAU - Vilavedra, Jose Francisco AU - Vilavedra JF AD - Ipensa Clinic, Ketogenic Therapy Team, La Plata, Argentina. LA - eng PT - Journal Article DEP - 20260612 PL - United States TA - Epilepsy Behav JT - Epilepsy & behavior : E&B JID - 100892858 RN - 0 (Triglycerides) RN - 0 (Anticonvulsants) SB - IM MH - Humans MH - *Drug Resistant Epilepsy/drug therapy/diet therapy MH - Male MH - Female MH - *Triglycerides/therapeutic use MH - Child MH - Retrospective Studies MH - *Diet, Ketogenic MH - Child, Preschool MH - Treatment Outcome MH - Adolescent MH - Anticonvulsants/therapeutic use MH - Seizures/drug therapy OTO - NOTNLM OT - Dietary therapy OT - Drug-resistant epilepsy OT - Ketogenic diet OT - MCT OT - Paediatric epilepsy COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Alberti Maria Julia has nothing to declare. de Clauser Larissa is an employee at Dr. Schar AG. Vilavedra Jose Francisco has nothing to declare. Viollaz Rocio has nothing to declare. EDAT- 2026/06/13 00:39 MHDA- 2026/08/01 00:36 CRDT- 2026/06/12 18:07 PHST- 2026/02/02 00:00 [received] PHST- 2026/06/04 00:00 [revised] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/08/01 00:36 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 18:07 [entrez] AID - S1525-5050(26)00283-0 [pii] AID - 10.1016/j.yebeh.2026.111162 [doi] PST - ppublish SO - Epilepsy Behav. 2026 Oct;183:111162. doi: 10.1016/j.yebeh.2026.111162. Epub 2026 Jun 12. PMID- 42284307 OWN - NLM STAT- MEDLINE DCOM- 20260614 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Comparative analysis of isokinetic ratios between hamstrings and quadriceps in wrestlers: Resting state versus post-fatigue evaluation. PG - e0342975 LID - 10.1371/journal.pone.0342975 [doi] LID - e0342975 AB - INTRODUCTION: Wrestling demands high-intensity competition, and tournament structures often require athletes to compete in multiple matches in a single day. This results in accumulated neuromuscular fatigue that may disrupt the balance between hamstring and quadriceps strength, potentially increasing the risk of knee injuries. Therefore, this study aimed to determine whether the conventional hamstring-quadriceps ratio (H: QConv) and functional hamstring-quadriceps ratio (H: QFunc) are more indicative in resting and post-fatigue states, examine the H: QConv and H: QFunc isokinetic strength ratios, and analyze the contributions of hamstring and quadriceps strength changes to these ratios. MATERIALS AND METHODS: The study involved 16 wrestlers who achieved national championship rankings. Their average age was 15.0 +/- 1.2 years, with an average height of 171.6 +/- 8.6 cm and weight of 65.1 +/- 16.6 kg. Their BMI was 21.8 +/- 4.0 kg/m(2), and they had an average of 4.3 +/- 1.0 years of training experience. The athletes participated in isokinetic assessments both at rest and after fatigue. The concentric and eccentric strengths of the hamstrings and concentric strength of the quadriceps were measured at angular velocities of 60 degrees /s and 180 degrees /s, respectively. RESULTS: Two-factor repeated-measures ANOVA revealed a highly significant main effect of time on quadriceps concentric (QCON)(F(1,15)=106.789, p < .001, eta(2)(p) = .877), and angular velocity and interaction were not significant. For HCON, there was no time effect, but the velocity effect was significant (60 degrees /s > 180 degrees /s; F(1,15)=31.771, p < .001, eta(2)(p) = .679). For hamstring eccentric (HECC), the time and interaction effects were insignificant, and the velocity remained at the threshold (F(1,15)=3.654, p = .075). The H: QConv ratio generally increased after fatigue (F = 17.492, p = .001), and there was a level difference between velocities (F = 9.147, p = .009), but the interaction was insignificant. Both time (F = 59.489, p < .001) and velocity (F = 6.716, p = .020) were significant for the H: QFunc ratio, as was the time x velocity interaction (F = 4.708, p = .046); the increase was particularly reliable at 60 degrees /s (Delta=+0.131, 95% CI [0.044, 0.218], p = .006). In the component decompositions, the increase in the time effect was shared similarly by the hamstrings and quadriceps, whereas the hamstrings' contribution significantly drove the angular velocity difference. CONCLUSION: Fatigue significantly reduced the concentric torque of the quadriceps, whereas the concentric/eccentric outputs of the hamstrings were relatively preserved; consequently, the H: Q balance increased, particularly at 60 degrees /s. The time effect was strong for H: QFunc, and a timexvelocity interaction was present: the increase was reliable at 60 degrees /s but not statistically confirmed at 180 degrees /s. Component decomposition showed that the time-related change was shared to a similar extent by both muscles, whereas the hamstring contribution predominantly explained the angular velocity difference. CI - Copyright: (c) 2026 Tatlici et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Tatlici, Ali AU - Tatlici A AD - Department of Physical Education and Sport Teaching, Faculty of Sport Sciences, Selcuk University, Konya, Turkiye. FAU - Kurtoglu, Ahmet AU - Kurtoglu A AUID- ORCID: 0000-0002-9292-5419 AD - Department of Coaching Education, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkiye. FAU - Yilmaz, Muhammed AU - Yilmaz M AD - Department of Coaching Education, Faculty of Sport Sciences, Selcuk University, Konya, Turkiye. FAU - Gungor, Halil AU - Gungor H AD - Department of Physical Education and Sport Teaching, Faculty of Sport Sciences, Selcuk University, Konya, Turkiye. FAU - Ozer, Omer AU - Ozer O AD - Department of Physical Education and Sport Teaching, Faculty of Sport Sciences, Bandirma Onyedi Eylul University, Balikesir, Turkiye. FAU - Car, Bekir AU - Car B AD - Department of Physical Education and Sport Teaching, Faculty of Sport Sciences, Bandirma Onyedi Eylul University, Balikesir, Turkiye. FAU - Muracki, Jaroslaw AU - Muracki J AD - Institute of Physical Culture Sciences, Department of Physical Culture and Health, University of Szczecin, Szczecin, Poland. FAU - Trybulski, Robert AU - Trybulski R AD - Medical Department, Wojciech Korfanty Upper Silesian Academy, Katowice, Poland. FAU - Aldhahi, Monira I AU - Aldhahi MI AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260612 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Hamstring Muscles/physiology MH - *Quadriceps Muscle/physiology MH - *Muscle Fatigue/physiology MH - *Wrestling/physiology MH - Male MH - Adolescent MH - *Muscle Strength/physiology MH - *Rest/physiology PMC - PMC13262851 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/12 18:41 MHDA- 2026/06/15 11:30 PMCR- 2026/06/12 CRDT- 2026/06/12 13:43 PHST- 2025/11/11 00:00 [received] PHST- 2026/02/01 00:00 [accepted] PHST- 2026/06/15 11:30 [medline] PHST- 2026/06/12 18:41 [pubmed] PHST- 2026/06/12 13:43 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - PONE-D-25-60422 [pii] AID - 10.1371/journal.pone.0342975 [doi] PST - epublish SO - PLoS One. 2026 Jun 12;21(6):e0342975. doi: 10.1371/journal.pone.0342975. eCollection 2026. PMID- 42282294 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 0973-2063 (Print) IS - 0973-2063 (Electronic) IS - 0973-2063 (Linking) VI - 22 IP - 4 DP - 2026 TI - Weight-for-age and mid-upper arm circumference versus weight-for-length as severe acute malnutrition indicators: A validation study in under-6-month infants. PG - 2305-2309 LID - 10.6026/973206300222305 [doi] AB - Infants are more susceptible to malnutrition than older children. The prevalence of severe wasting among Indian infants under-6 months of age is 14.8% according to the National Family Health Survey-4. The myth of complete protection by exclusive breastfeeding is debated when the prevalence of severe acute malnutrition (SAM) sprang up as high as 23.8% in a cross sectional study from Central India among 600 infants. Area under the curve for MUAC <11 cm was 0.936 (95% confidence interval); its sensitivity and specificity were 69.23% and 73.09%, respectively; area under the curve for weight-for-age had higher sensitivity at (88.81%), but lower specificity (61.1%). The highlighted modifiable risk factors were low birth weight and adverse feeding practices. Combined MUAC and weight-for-length screening strategies should be used specifically in low-resource, community-based contexts for SAM in infants aged under six months. CI - (c) 2026 Biomedical Informatics. FAU - Pinky, Kumari AU - Pinky K AD - Department of Paediatrics, Government Medical College, Satna, Madhya Pradesh, India. FAU - Mahore, Rashmi Randa AU - Mahore RR AD - Department of Pediatrics, GMC Bhopal, Madhya Pradesh, India. FAU - Thakur, Shiva Saloni AU - Thakur SS AD - Department of Pediatrics, Civil hospital Amarwara, Chhindwara, Madhya Pradesh, India. FAU - Parmar, Sachin AU - Parmar S AD - Department of Community Medicine, V.K.S. Government Medical College, Neemuch, India. LA - eng PT - Journal Article DEP - 20260430 PL - Singapore TA - Bioinformation JT - Bioinformation JID - 101258255 PMC - PMC13252213 OTO - NOTNLM OT - Severe acute malnutrition (SAM) OT - infants under six months OT - mid-upper arm circumference (MUAC) EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/04/30 CRDT- 2026/06/12 05:02 PHST- 2026/04/01 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 05:02 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 973206300222305 [pii] AID - 10.6026/973206300222305 [doi] PST - epublish SO - Bioinformation. 2026 Apr 30;22(4):2305-2309. doi: 10.6026/973206300222305. eCollection 2026. PMID- 42281579 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Dietary Index for Gut Microbiota and the Odds of Metabolic Dysfunction-Associated Fatty Liver Disease in Overweight and Obese Children and Adolescents: A Cross-Sectional Study. PG - e72640 LID - 10.1002/hsr2.72640 [doi] LID - e72640 AB - BACKGROUND AND AIMS: Metabolic dysfunction-associated fatty liver disease (MAFLD) is increasingly prevalent among children and adolescents with overweight or obesity, posing a growing public health challenge. Emerging evidence highlights the gut microbiota as a critical mediator in MAFLD pathogenesis, yet few studies have explored dietary factors influencing this axis in pediatric populations. This cross-sectional study investigated the association between the Dietary Index for Gut Microbiota (DI-GM) and MAFLD. METHODS: A total of 505 Iranian youths aged 7-18 years enrolled in a national obesity registry. Dietary intake was assessed via a validated 147-item Food Frequency Questionnaire. MAFLD was diagnosed according to international expert consensus, requiring ultrasound‑confirmed hepatic steatosis in the presence of overweight/obesity or other metabolic abnormalities. RESULTS: Multivariable logistic regression models revealed that higher DI-GM scores were significantly associated with lower odds of MAFLD (OR per unit increase: 0.80, 95% CI: 0.71-0.91; p < 0.001). Participants in the highest DI-GM quartile had markedly reduced risk compared to the lowest quartile (OR: 0.42, 95% CI: 0.22-0.81). Notably, the inverse association was significant only among post-pubertal participants. Mediation analysis indicated that liver enzymes-alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and aspartate aminotransferase (AST)-partially explained this relationship, accounting for 20.0%, 19.2%, and 6.7% of the association, respectively. CONCLUSION: These findings underscore the potential of microbiota-oriented dietary strategies to mitigate MAFLD risk in pediatric populations with obesity. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Kamrani, Farzam AU - Kamrani F AUID- ORCID: 0009-0001-2460-4218 AD - Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran. FAU - Nikparast, Ali AU - Nikparast A AUID- ORCID: 0000-0003-2686-2584 AD - Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition & Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran. FAU - Tabatabaeyan, Ali AU - Tabatabaeyan A AUID- ORCID: 0009-0005-9974-3537 AD - Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Students' Research Committee Isfahan University of Medical Sciences Isfahan Iran. FAU - Etesami, Elahe AU - Etesami E AD - Department of Nutrition SR.C., Islamic Azad University Tehran Iran. FAU - Rohani, Pejman AU - Rohani P AD - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences Tehran Iran. FAU - Asghari, Golaleh AU - Asghari G AUID- ORCID: 0000-0002-7925-5158 AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13250465 OTO - NOTNLM OT - Dietary Index for Gut Microbiota OT - MAFLD OT - adolescent OT - children OT - metabolic dysfunction-associated fatty liver disease COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/06/10 CRDT- 2026/06/12 04:54 PHST- 2025/10/10 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 04:54 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - HSR272640 [pii] AID - 10.1002/hsr2.72640 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 10;9(6):e72640. doi: 10.1002/hsr2.72640. eCollection 2026 Jun. PMID- 42281577 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Household Water and Sanitation Practices and Their Association With Diarrheal and Acute Respiratory Infections Among Children Under Five in Ghana: A Cross-Sectional Predictive Model and Spatial Analysis. PG - e72628 LID - 10.1002/hsr2.72628 [doi] LID - e72628 AB - BACKGROUND AND AIMS: Diarrhea and acute respiratory infections (ARI) remain leading causes of under-five morbidity in low- and middle-income countries. Although Ghana achieved improved drinking water and sanitation coverage, significant regional and socioeconomic inequities persist. This study examined the associations between household water, sanitation, and hygiene (WASH) practices and diarrhea, ARI, and their comorbidity among under-five children in Ghana. METHODS: A cross-sectional analysis of 6344 children aged 0-59 months from the 2022 Ghana Demographic and Health Survey was conducted. Survey-weighted descriptive statistics and multilevel logistic regression were applied. Predictive performance was assessed using fivefold cluster-preserving cross-validation, Brier scores, calibration slopes, calibration plots, and cross-validated area under the curve (AUC). Spatial patterns were described using choropleth maps, Global Moran's I, Getis-Ord Gi*, and Local Moran's I (LISA). Counterfactual WASH reductions were estimated with bootstrap confidence intervals (200 replicates). A complementary random-effects meta-analysis quantified between-region heterogeneity (I(2)). RESULTS: Two-week prevalence of diarrhea, ARI, and comorbidity was 14.4% (95% CI: 12.7%-16.3%), 5.6% (95% CI: 4.7%-6.6%), and 1.8% (95% CI: 1.3%-2.5%), respectively, with a pronounced north-south gradient. No WASH variable reached significance in adjusted multilevel models. Diarrhea was associated with child age 6-35 months, maternal secondary and higher education, and household wealth. ARI was associated with co-occurring diarrhea and stunting. Stunting was the sole significant predictor of comorbidity. Community-level factors explained 21%-35% of variance. Cross-validated AUC was 0.787 (diarrhea), 0.896 (ARI), and 0.577 (comorbidity); calibration slopes were 3.68-11.68 (all poor). Global Moran's I showed no significant spatial autocorrelation for all three outcomes. Improving cooking fuel universally was the only scenario associated with a statistically significant absolute reduction in diarrhea prevalence: 1.4% points (relative reduction 13.9%; 95% CI: 6.2%-21.6%). CONCLUSIONS: Household WASH infrastructure showed no significant adjusted association with childhood diarrhea, ARI, or comorbidity after controlling for socioeconomic and nutritional confounders. A pronounced north-south disease gradient calls for geographically targeted, multisectoral interventions. Predictive models demonstrated adequate discrimination but poor calibration, limiting their use to population-level risk stratification. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Salifu, Yula AU - Salifu Y AUID- ORCID: 0000-0003-1223-1765 AD - Department of Population, Family and Reproductive Health, School of Public Health University of Ghana Legon Ghana. FAU - Gyan, Paul AU - Gyan P AD - Health Facilities Regulatory Agency Ashanti Region Ghana. FAU - Lasong, Joseph AU - Lasong J AD - Department of Population and Reproductive Health University for Development Studies Tamale Ghana. FAU - Walana, Williams AU - Walana W AUID- ORCID: 0000-0002-2938-1332 AD - Department of Clinical Microbiology, School of Medicine University for Development Studies Tamale Ghana. LA - eng PT - Journal Article DEP - 20260609 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13250393 OTO - NOTNLM OT - Ghana OT - WASH OT - acute respiratory infections OT - children under five OT - demographic and health survey OT - diarrhea OT - multilevel modeling OT - predictive modeling OT - spatial analysis COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/06/09 CRDT- 2026/06/12 04:54 PHST- 2025/10/24 00:00 [received] PHST- 2026/04/04 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 04:54 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - HSR272628 [pii] AID - 10.1002/hsr2.72628 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 9;9(6):e72628. doi: 10.1002/hsr2.72628. eCollection 2026 Jun. PMID- 42281323 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 27 IP - 3 DP - 2026 Mar 1 TI - Evaluation of a Novel Zygomatic-based Cephalometric Angle for Sagittal Skeletal Discrepancy: A Retrospective Study. PG - 304-309 LID - 10.5005/jp-journals-10024-4036 [doi] AB - AIM: To evaluate the diagnostic accuracy of a novel zygomatic-based cephalometric parameter, the ZYen angle, for assessing sagittal skeletal discrepancies. MATERIALS AND METHODS: This retrospective cross-sectional study analyzed 369 pretreatment lateral cephalograms of subjects aged 18-25 years, equally distributed into skeletal class I (n = 123), class II (n = 123), and class III (n = 123) groups. Skeletal classification was performed using the A point-nasion-B point angle (ANB) and Wits appraisal. The ZYen angle, defined using points M, Z (zygomatic point), and D, was measured, and its diagnostic performance was assessed using one-way analysis of variance (ANOVA) and receiver operating characteristic (ROC) curve analysis to determine sensitivity, specificity, and area under the curve (AUC). RESULTS: The ZYen angle showed significant differences among skeletal classes (p < 0.001). Receiver operating characteristic analysis demonstrated excellent discrimination between skeletal class I and class III (AUC = 0.908), with a cut-off value of 29.5 degrees providing balanced sensitivity (78.9%) and specificity (82.9%). In contrast, discrimination between class I and class II was poor (AUC = 0.594), indicating limited diagnostic ability for identifying class II patterns. CONCLUSION: The ZYen angle is a reliable sagittal skeletal parameter with high diagnostic accuracy for distinguishing class I from class III relationships but limited utility in differentiating class II malocclusions. CLINICAL SIGNIFICANCE: Accurate sagittal skeletal diagnosis is essential for orthodontic treatment planning and prognosis. The ZYen angle utilizes stable zygomatic landmarks and minimizes reliance on cranial base and dental reference points, enhancing diagnostic confidence in class III cases. It may serve as a clinically useful adjunct to conventional cephalometric parameters, particularly in borderline or ambiguous sagittal discrepancies. CI - (c) The Author(s). 2026 Open Access. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/). This license permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited, a link to the license is included, and any changes are indicated. FAU - Shetty, Subramanya AU - Shetty S AUID- ORCID: 0009-0001-0803-7938 AD - Department of Orthodontics and Dentofacial Orthopaedics, Yenepoya Dental College, Yenepoya University, Mangaluru, Karnataka, India. FAU - Umar, Dilshad AU - Umar D AUID- ORCID: 0000-0002-1130-9359 AD - Department of Orthodontics and Dentofacial Orthopaedics, Yenepoya Dental College, Yenepoya University, Mangaluru, Karnataka, India, e-mail: orthodil@gmail.com. FAU - Egipsy, Kelly Ctm AU - Egipsy KC AUID- ORCID: 0009-0002-6999-8123 AD - Department of Orthodontics and Dentofacial Orthopaedics, Yenepoya Dental College, Yenepoya University, Mangaluru, Karnataka, India. FAU - Khais, Mohammed AU - Khais M AUID- ORCID: 0009-0001-4697-8499 AD - Department of Orthodontics and Dentofacial Orthopaedics, Yenepoya Dental College, Yenepoya University, Mangaluru, Karnataka, India. LA - eng PT - Journal Article DEP - 20260301 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 SB - IM MH - Humans MH - *Cephalometry/methods MH - Retrospective Studies MH - *Zygoma/diagnostic imaging/anatomy & histology MH - Adolescent MH - Cross-Sectional Studies MH - Adult MH - Female MH - Young Adult MH - Male MH - Sensitivity and Specificity MH - ROC Curve MH - *Malocclusion/diagnosis/diagnostic imaging MH - Malocclusion, Angle Class II MH - Malocclusion, Angle Class III MH - Malocclusion, Angle Class I OTO - NOTNLM OT - Cephalometry OT - Malocclusion OT - Sagittal skeletal discrepancy OT - Zygoma COIS- None EDAT- 2026/06/12 06:39 MHDA- 2026/06/13 00:39 CRDT- 2026/06/12 02:44 PHST- 2026/02/03 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/06/13 00:39 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 02:44 [entrez] AID - 10.5005/jp-journals-10024-4036 [doi] PST - epublish SO - J Contemp Dent Pract. 2026 Mar 1;27(3):304-309. doi: 10.5005/jp-journals-10024-4036. PMID- 42281312 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 27 IP - 3 DP - 2026 Mar 1 TI - Morphometric Evaluation of Cervical Vertebral Age and Mandibular Growth in Skeletal Class II Individuals Using Digital Cephalometry: A Cross-sectional Study. PG - 231-236 LID - 10.5005/jp-journals-10024-4008 [doi] AB - AIMS: This study examined the association between morphometric cervical vertebral bone (CVB) age and mandibular growth in Saudi individuals with skeletal class II malocclusion. MATERIALS AND METHODS: A retrospective cross-sectional analysis was performed using archived digital lateral cephalograms of 56 Saudi patients with skeletal class II malocclusion. Radiographs were categorized into a pubertal group (8-13 years; n = 28) and a postpubertal group (17-21 years; n = 28), with each group equally stratified by gender (14 males and 14 females). Mandibular length estimates calculated during the pubertal phase were compared with measured mandibular dimensions in postpubertal subjects, and sex-related growth differences were evaluated. Cervical vertebral bone age was calculated using vertebral morphometric measurements, and mandibular length (Condylion-Gnathion) was digitally assessed. Predicted mandibular lengths derived from CVB age were statistically compared with observed postpubertal values using independent t-tests, Cohen's d, and descriptive Bland-Altman analysis. RESULTS: Chronological age (CA) demonstrated no significant discrepancy from CVB age in either males (p = 0.28) or females (p = 0.63). Mandibular lengths predicted during the pubertal phase did not differ significantly from observed mandibular dimensions in the postpubertal group, for both sexes (p > 0.05). Bland-Altman analysis demonstrated minimal bias and acceptable group-level agreement, with higher precision in females. Males exhibited greater but more variable estimated growth potential than females. CONCLUSION: Morphometric CVB age showed good group-level agreement between mandibular length predicted during the pubertal phase (8-13 years) and measured postpubertal values (17-21 years) in Saudi skeletal class II subjects. CLINICAL SIGNIFICANCE: Accurate assessment of mandibular growth timing remains essential for optimizing orthopedic intervention in skeletal class II malocclusion. This study highlights the clinical applicability of CVB morphometric assessment as a practical, radiation-free approach using routine cephalograms to estimate mandibular growth potential and support informed treatment timing decisions. CI - (c) The Author(s). 2026 Open Access. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/). This license permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited, a link to the license is included, and any changes are indicated. FAU - Almugla, Yousef M AU - Almugla YM AD - Department of Preventive Dental Sciences, College of Dentistry, King Faisal University, Al Ahsa, Saudi Arabia, Phone: +966558555548, e-mail: yalmugla@kfu.edu.sa. LA - eng PT - Journal Article DEP - 20260301 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 SB - IM MH - Humans MH - *Cervical Vertebrae/growth & development/diagnostic imaging/anatomy & histology MH - Adolescent MH - Cross-Sectional Studies MH - *Cephalometry/methods MH - *Malocclusion, Angle Class II/diagnostic imaging/physiopathology MH - Female MH - *Mandible/growth & development/diagnostic imaging MH - Child MH - Male MH - Retrospective Studies MH - *Age Determination by Skeleton/methods MH - Young Adult MH - Saudi Arabia OTO - NOTNLM OT - Cephalometric analysis OT - Cervical vertebral age OT - Class II malocclusion OT - Jaw bone OT - Mandibular growth OT - Orthodontics OT - Prediction COIS- None EDAT- 2026/06/12 06:37 MHDA- 2026/06/12 06:38 CRDT- 2026/06/12 02:44 PHST- 2025/12/25 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/06/12 06:38 [medline] PHST- 2026/06/12 06:37 [pubmed] PHST- 2026/06/12 02:44 [entrez] AID - 10.5005/jp-journals-10024-4008 [doi] PST - epublish SO - J Contemp Dent Pract. 2026 Mar 1;27(3):231-236. doi: 10.5005/jp-journals-10024-4008. PMID- 42280911 OWN - NLM STAT- MEDLINE DCOM- 20260616 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 11 DP - 2026 May 27 TI - Longitudinal Development of Neuromuscular Performance and Multidirectional Speed in Youth Badminton Players: Evidence for Parallel Adaptation Trajectories. LID - 10.3390/s26113393 [doi] LID - 3393 AB - This study examined long-term neuromuscular and multidirectional speed development in elite youth badminton players and evaluated whether developmental stage influences adaptation trajectories during systematic training. Thirty athletes were monitored over 16 months with repeated assessments at five time points and stratified into Younger (8-14 years) and Older (15-22 years) developmental groups. A comprehensive test battery assessed explosive strength, reactive strength, musculotendinous stiffness, and badminton-specific multidirectional speed. Data acquisition was performed using a multi-sensor approach, including force-platform-based jump analysis, accelerometry-based systems, and electronic timing gates, enabling the objective, high-resolution, and repeatable monitoring of neuromuscular performance. Significant time effects were observed across all sensor-derived performance variables (p < 0.001), indicating robust improvements in speed, power, and neuromuscular efficiency. Adaptation trajectories were predominantly linear, with no evidence of performance plateauing. Although older athletes maintained higher absolute performance levels, Time x Group interactions were largely absent, demonstrating parallel improvement rates across developmental stages rather than a catch-up effect in younger players. Linear mixed models confirmed equivalent improvement slopes despite baseline differences, and adjustment for body mass attenuated but did not eliminate age-group differences in jump performance. Exploratory analyses revealed substantial inter-individual variability, identifying responder phenotypes independent of age. These findings indicate that systematically progressed training supports sustained, linear neuromuscular adaptation across youth badminton development and highlight the importance of long-term, individualized monitoring over age-based expectations of accelerated responsiveness. FAU - Gepfert, Mariola AU - Gepfert M AUID- ORCID: 0000-0002-9749-5278 AD - Institute of Sport Sciences, Academy of Physical Education, 40-065 Katowice, Poland. FAU - Golas, Artur AU - Golas A AUID- ORCID: 0000-0002-6656-6993 AD - Institute of Sport Sciences, Academy of Physical Education, 40-065 Katowice, Poland. FAU - Maszczyk, Adam AU - Maszczyk A AUID- ORCID: 0000-0001-9139-9747 AD - Institute of Sport Sciences, Academy of Physical Education, 40-065 Katowice, Poland. FAU - Zajac, Adam AU - Zajac A AUID- ORCID: 0000-0002-4374-4822 AD - Institute of Sport Sciences, Academy of Physical Education, 40-065 Katowice, Poland. FAU - Zwierzchowska, Anna AU - Zwierzchowska A AUID- ORCID: 0000-0002-4284-8697 AD - Institute of Sport Sciences, Academy of Physical Education, 40-065 Katowice, Poland. LA - eng PT - Journal Article DEP - 20260527 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Child MH - Adolescent MH - Young Adult MH - *Racquet Sports MH - *Athletic Performance MH - *Muscle, Skeletal/physiology MH - Muscle Strength MH - Time Factors MH - Longitudinal Studies MH - Accelerometry MH - Body Mass Index MH - Adaptation, Physiological PMC - PMC13258960 OTO - NOTNLM OT - motor abilities OT - racquet sports OT - reactive strength OT - sensor-based monitoring COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/13 00:40 PMCR- 2026/05/27 CRDT- 2026/06/12 01:13 PHST- 2026/02/17 00:00 [received] PHST- 2026/03/26 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/06/13 00:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:13 [entrez] PHST- 2026/05/27 00:00 [pmc-release] AID - s26113393 [pii] AID - sensors-26-03393 [pii] AID - 10.3390/s26113393 [doi] PST - epublish SO - Sensors (Basel). 2026 May 27;26(11):3393. doi: 10.3390/s26113393. PMID- 42280454 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 Jun 4 TI - Exploring Subpopulations for Epidemiological Precision Nutrition Research: The Example of Phenylalanine Hydroxylase (PAH) Genetic Variation. LID - 10.3390/nu18111811 [doi] LID - 1811 AB - Background/Objectives: Biological factors such as genetics contribute to nutrition-related outcomes, but nutritional epidemiological studies often lack consideration of genetics despite evidence of their functional impacts on health and cognition. Phenylalanine hydroxylase (PAH) genetic variation has been hypothesized to influence health and cognitive outcomes due to evidence of metabolic perturbations in L-phenylalanine to L-tyrosine hydroxylation, including plausible downstream effects on catecholamine neurotransmitters among not only individuals with phenylketonuria (PKU) [homozygotes for PAH mutations] but also PKU carriers [heterozygotes]. Related to these metabolic perturbations, diminished executive functioning has been observed in individuals with PKU, even when treated, but research is lacking exploring this outcome in PKU carriers. The present study aims to detail methods for stratifying populations based on genetic variation, for use in epidemiological precision nutrition research. It further provides an exploratory exemplar of such research through population stratification by PAH genetic variation (i.e., PKU carriers vs. non-carriers), while providing the first descriptive data on executive functioning skills using the validated Executive Skills Questionnaire-Revised (ESQ-R) tool with PAH-genetically stratified groups (PKU carriers and non-carriers). Methods: Participants were >/=18 years of age and PAH heterozygotes (PKU carriers) or non-carriers. Levels of executive functioning were self-reported anonymously online and included the validated Executive Skills Questionnaire-Revised (ESQ-R) tool. Data were analyzed using t-tests, chi-square tests, ANOVAs, and ANCOVAs. Results: Respondents (n = 99, n = 79 carriers and n = 20 non-carriers) consisted of males (22.2%) and females (77.8%), primarily of European ancestry. There were no significant differences between groups (carriers vs. non-carriers) for total scores (mean +/- SD ESQ-R score carriers = 17.41 +/- 14.01; non-carriers = 14.95 +/- 10.00), but carriers scored significantly worse than non-carriers for the ESQ-R item "I have trouble making a plan" in the adjusted model. Conclusions: This study provides a methodological exemplar for exploring genetically stratified subpopulations in epidemiological precision nutrition research. FAU - Dhawan, Anoushka AU - Dhawan A AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Khan, Sophia M AU - Khan SM AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Fennell, Madison L AU - Fennell ML AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Cho, Clara E AU - Cho CE AUID- ORCID: 0000-0002-9733-2516 AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Monk, Jennifer M AU - Monk JM AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Keathley, Justine R AU - Keathley JR AUID- ORCID: 0000-0002-9176-9645 AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. LA - eng PT - Journal Article DEP - 20260604 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - EC 1.14.16.1 (Phenylalanine Hydroxylase) SB - IM MH - Humans MH - *Phenylalanine Hydroxylase/genetics MH - *Phenylketonurias/genetics MH - Female MH - *Genetic Variation MH - Male MH - Adult MH - Heterozygote MH - Executive Function MH - Young Adult MH - Adolescent MH - Middle Aged PMC - PMC13259265 OTO - NOTNLM OT - PKU OT - PKU parents OT - executive functioning OT - heterozygotes OT - phenylketonuria COIS- The authors declare no conflict of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/15 11:34 PMCR- 2026/06/04 CRDT- 2026/06/12 01:11 PHST- 2026/04/28 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/15 11:34 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/06/04 00:00 [pmc-release] AID - nu18111811 [pii] AID - nutrients-18-01811 [pii] AID - 10.3390/nu18111811 [doi] PST - epublish SO - Nutrients. 2026 Jun 4;18(11):1811. doi: 10.3390/nu18111811. PMID- 42280414 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 30 TI - Cultural and Sex-Related Differences in Free-Word Associations with "Sweets": A Multinational Online Study. LID - 10.3390/nu18111771 [doi] LID - 1771 AB - Background: Free-word association (FWA) captures the most accessible lexical responses to a stimulus, providing a window into automatic cognitive representations of food categories that may differ across cultures and between sexes. Objectives: To examine whether the dominant cognitive associations evoked by the word "sweets" differ across three language groups (Hungarian, English, Spanish), whether they vary by sex, and whether they relate to body mass index (BMI) and self-reported eating disorder risk. Methods: A total of 1349 participants completed an online survey including a single FWA prompt. Responses were classified into 10 semantic categories and analyzed using chi-square tests. Effect sizes (Cramer's V) were reported for all tests. Height and weight were converted to uniform metric units, and BMI was calculated. Results: The association profile differed significantly across language groups (chi(2)[18] = 210.05, p < 0.001, V = 0.28). Chocolate dominated Hungarian responses, while Baked goods/Desserts and Sugar/Candy dominated English, and Positive emotion and Baked goods/Desserts predominated among Spanish speakers. Sex differences were significant overall (chi(2)[9] = 43.72, p < 0.001, V = 0.18). BMI distributions differed markedly across nations (chi(2)[6] = 157.17, p < 0.001, V = 0.26), and sweets categories were significantly associated with eating disorder risk (chi(2)[27] = 48.04, p = 0.008, V = 0.11); however, this result should be interpreted with caution given the extreme skew toward the lowest-risk category [84.2%], with Negative/Health associations overrepresented among higher-risk participants. Conclusions: Cultural context plays a significant role in shaping automatic cognitive associations with sweet foods. The exploratory association between sweets categories and self-reported eating disorder risk warrants further investigation using validated instruments before any substantive conclusions can be drawn. FAU - Avena, Nicole AU - Avena N AD - Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - Health Psychology, Princeton University, Princeton, NJ 08544, USA. FAU - Kovacs, Reka Erika AU - Kovacs RE AUID- ORCID: 0009-0007-0243-6878 AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, 9026 Gyor, Hungary. FAU - Somogyi, Angela AU - Somogyi A AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, 9026 Gyor, Hungary. FAU - de la Vega, Ricardo AU - de la Vega R AUID- ORCID: 0000-0002-7395-3297 AD - Departamento de Educacion Fisica, Deporte y Motricidad Humana, Universidad Autonoma de Madrid, 28049 Madrid, Spain. FAU - Szabo, Attila AU - Szabo A AUID- ORCID: 0000-0003-2788-4304 AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, 9026 Gyor, Hungary. LA - eng PT - Journal Article DEP - 20260530 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - Body Mass Index MH - Sex Factors MH - Adult MH - Feeding and Eating Disorders/psychology MH - Young Adult MH - Language MH - *Food Preferences/psychology/ethnology MH - *Cross-Cultural Comparison MH - Adolescent MH - Surveys and Questionnaires MH - Cognition PMC - PMC13258868 OTO - NOTNLM OT - BMI OT - cross-cultural OT - eating behavior OT - eating disorders OT - free-word association OT - sex differences COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/13 00:38 PMCR- 2026/05/30 CRDT- 2026/06/12 01:11 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - nu18111771 [pii] AID - nutrients-18-01771 [pii] AID - 10.3390/nu18111771 [doi] PST - epublish SO - Nutrients. 2026 May 30;18(11):1771. doi: 10.3390/nu18111771. PMID- 42280409 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 30 TI - Oral Mycobiome Alterations in Children with Phenylketonuria: Associations with Dietary Intake and Metabolic Context-A Pilot Study. LID - 10.3390/nu18111764 [doi] LID - 1764 AB - BACKGROUND: Phenylketonuria (PKU) is a metabolic disorder requiring a strict low-phenylalanine diet. Oral health impairment, including bacteriome dysbiosis, is common in PKU, yet the mycobiome remains poorly defined. This pilot study aimed to characterise the salivary oral mycobiome of children with PKU compared with controls and to explore associations with dietary intake. METHODS: Saliva samples from 18 children, including 8 patients with PKU and 10 age-matched controls, were profiled using internal transcribed spacer (ITS) amplicon sequencing. Alpha/beta diversity, taxonomic composition, diet-fungi correlations, discriminative taxa and LEfSe were analysed. RESULTS: Alpha diversity did not differ significantly between groups after correction for multiple comparisons, although exploratory subgroup analyses suggested lower evenness in PKU children aged <10 years compared with older controls. Beta diversity differed by diagnosis (PERMANOVA: F = 1.7251, p = 0.0062) and in the age-diagnosis model (F = 1.8502, p = 0.0004). Taxonomic analyses identified nominal differences in several fungal taxa, including Candida (p = 0.011), Saccharomycetales_fam_Incertae_sedis (p = 0.011), Naganishia (p = 0.020), and Aspergillaceae (p = 0.036) in PKU samples; however, these findings should be interpreted as exploratory because many did not remain significant after FDR correction. Diet-mycobiome analyses identified selected FDR-supported associations, including an inverse relationship between phenylalanine intake and Naganishia in PKU. CONCLUSIONS: This pilot study suggests preliminary compositional differences in the oral mycobiome of children with PKU that may be related to dietary therapy and metabolic context. These exploratory findings require validation in larger cohorts with detailed oral health assessment and control of confounders. FAU - Ostrowska, Malgorzata AU - Ostrowska M AUID- ORCID: 0000-0002-1218-3225 AD - Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland. FAU - Komon-Janczara, Elwira AU - Komon-Janczara E AUID- ORCID: 0000-0003-4579-4994 AD - Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland. FAU - Mikoluc, Bozena AU - Mikoluc B AUID- ORCID: 0000-0002-8284-6426 AD - Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, 15-274 Bialystok, Poland. FAU - Ilowiecka, Katarzyna AU - Ilowiecka K AD - Nutrition Clinic, Department of Clinical Dietetics, Medical University of Lublin, 20-093 Lublin, Poland. FAU - Jarczak, Justyna AU - Jarczak J AUID- ORCID: 0000-0002-4357-7681 AD - Laboratory of Regenerative Medicine, Preclinical Research and Technology Center, Medical University of Warsaw, 02-097 Warsaw, Poland. FAU - Zagorska, Justyna AU - Zagorska J AUID- ORCID: 0000-0002-7869-2882 AD - Department of Food and Nutrition, Medical University of Lublin, 20-093 Lublin, Poland. FAU - Zambrzycka, Paulina AU - Zambrzycka P AD - Metabolic Clinic, Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Ludwig Zamenhoff University Children's Clinical Hospital, Medical University of Bialystok, 15-274 Bialystok, Poland. FAU - Turroni, Silvia AU - Turroni S AUID- ORCID: 0000-0003-2345-9482 AD - Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy. FAU - Szczerba, Hubert AU - Szczerba H AD - Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland. LA - eng GR - 2022/06/X/NZ9/00519/National Science Centre/ PT - Journal Article DEP - 20260530 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Phenylketonurias/microbiology/metabolism MH - Pilot Projects MH - Male MH - Female MH - Child MH - *Diet MH - *Saliva/microbiology MH - *Mycobiome MH - Child, Preschool MH - Case-Control Studies MH - *Mouth/microbiology MH - *Fungi/classification PMC - PMC13259183 OTO - NOTNLM OT - fungal community shifts OT - metabolic disorders OT - nutrient-microbiome interactions OT - oral mycobiome OT - pediatric nutrition OT - phenylketonuria (PKU) COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/15 11:36 PMCR- 2026/05/30 CRDT- 2026/06/12 01:11 PHST- 2026/04/30 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/15 11:36 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - nu18111764 [pii] AID - nutrients-18-01764 [pii] AID - 10.3390/nu18111764 [doi] PST - epublish SO - Nutrients. 2026 May 30;18(11):1764. doi: 10.3390/nu18111764. PMID- 42280399 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 29 TI - Ponderal Status, Eating and Lifestyle Habits in Rural School Children: A Pilot Survey of the SBAM-ONFOODS Cohort Study. LID - 10.3390/nu18111756 [doi] LID - 1756 AB - Background/Objectives: The rising prevalence of overweight and obesity reflects a trend towards worsening eating habits and reduced physical activity, with significant implications for public health and life expectancy. This pilot survey aimed to evaluate weight status, food habits and lifestyle in primary school children from under-researched rural areas of the Lazio region, Italy. Methods: A total of 182 children aged 6-10 years from the municipalities of Monte Romano and Tolfa were enrolled. Body Mass Index (BMI), calculated from measured weight and height, was classified by IOTF and WHO definitions. Food habits, socioeconomic factors and lifestyle were evaluated by a standard questionnaire, and adherence to the Mediterranean diet (MD) was assessed by the KIDMED test. Results: Data showed a high prevalence of overweight, including obesity (33.3%), based on IOTF criteria, with slightly higher rates in boys than girls (38.3% vs. 26.9%). According to the WHO definition, the rate of overweight/obesity was 39.5% with significant differences between males and females (46% vs. 30.8%). Only 19.9% of children had high adherence to MD (67.3% moderate, 12.9% low), and 29.5% of the sample did not eat breakfast every day. In addition, 25.4% met international physical activity recommendations, while around 40% exceeded the recommended screen time on weekend days, and 19.3% did not sleep the recommended hours. Conclusions: Preliminary data show high rates of excess weight, poor diet quality and unhealthy lifestyles. Extending the sampling to other municipalities in the study area will help validate these findings and provide deeper insights to inform targeted intervention strategies. FAU - Galfo, Myriam AU - Galfo M AUID- ORCID: 0000-0003-4037-2979 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. FAU - D'Addezio, Laura AU - D'Addezio L AUID- ORCID: 0000-0003-3392-5539 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. FAU - Roccaldo, Romana AU - Roccaldo R AUID- ORCID: 0000-0003-2976-3864 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. FAU - Censi, Laura AU - Censi L AUID- ORCID: 0000-0002-8769-6914 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. LA - eng GR - PE00000003/European Union/ PT - Journal Article DEP - 20260529 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Pilot Projects MH - *Feeding Behavior MH - *Life Style MH - *Rural Population/statistics & numerical data MH - Italy/epidemiology MH - Body Mass Index MH - Prevalence MH - Diet, Mediterranean MH - Overweight/epidemiology MH - *Pediatric Obesity/epidemiology MH - Cohort Studies MH - Exercise MH - Socioeconomic Factors MH - Surveys and Questionnaires PMC - PMC13258498 OTO - NOTNLM OT - children OT - food habits OT - lifestyle OT - ponderal status COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/15 11:31 PMCR- 2026/05/29 CRDT- 2026/06/12 01:11 PHST- 2026/04/21 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/15 11:31 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - nu18111756 [pii] AID - nutrients-18-01756 [pii] AID - 10.3390/nu18111756 [doi] PST - epublish SO - Nutrients. 2026 May 29;18(11):1756. doi: 10.3390/nu18111756. PMID- 42280338 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 26 TI - Development of a Metagenomics-Guided Personalized Synbiotic Protocol for Children with Autism Spectrum Disorder: An Exploratory Case Series. LID - 10.3390/nu18111694 [doi] LID - 1694 AB - BACKGROUND/OBJECTIVES: Gut microbiota dysregulation has been increasingly implicated in the pathophysiology of autism spectrum disorder (ASD), yet clinical responses to standardized probiotic interventions remain inconsistent, likely reflecting substantial inter-individual variability in baseline microbiome composition, host-microbe interactions, immune tone, and metabolic function. Here, we present a pilot implementation of a metagenomics-guided, personalized synbiotic intervention in children with ASD using the Systematic Microbiome Assessment and Reconstruction Therapy (SMART) framework. METHODS: Seven children (aged 5-12 years) underwent longitudinal fecal shotgun metagenomic profiling, and dietary habits, food sensitivities, and regional dietary background were recorded as contextual factors potentially influencing microbiome composition and response to intervention. Individualized synbiotic formulations were constructed based on microbial taxonomic composition and inferred functional capacity and iteratively refined over time. Gastrointestinal outcomes were assessed through caregiver-reported clinical observations, whereas behavioral changes were evaluated using standardized instruments. RESULTS: Several participants demonstrated improvements in gastrointestinal symptoms and selected behavioral domains. Notably, in a subset of participants, improvements in gastrointestinal function preceded measurable behavioral changes. CONCLUSIONS: Although limited by a small sample size and lack of a control group, these findings provide preliminary evidence supporting the feasibility of implementing a metagenomics-guided personalized synbiotic framework in ASD and generate hypotheses for future investigation. This work presents a preliminary conceptual framework for integrating microbial composition and inferred functional profiling into individualized intervention design and highlights the potential value of microbiome-informed stratification in future studies of treatment response. Larger controlled studies with objective outcome measures are warranted to further evaluate feasibility, reproducibility, and potential clinical utility. FAU - Zhang, Shaohan AU - Zhang S AUID- ORCID: 0009-0009-4106-4928 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Liu, Kevin AU - Liu K AUID- ORCID: 0000-0002-8754-3504 AD - Fetal-Neonatal Neuroimaging and Developmental Science Center, Department of Newborn Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA. FAU - Shi, Leo AU - Shi L AUID- ORCID: 0009-0001-6741-7746 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Yan, Chuyao AU - Yan C AUID- ORCID: 0009-0008-8933-5224 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Wang, Alma AU - Wang A AUID- ORCID: 0009-0000-1366-9051 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Liu, Ashley AU - Liu A AUID- ORCID: 0009-0002-4208-425X AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Guo, Haiyi AU - Guo H AUID- ORCID: 0009-0000-3777-4892 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. AD - Fetal-Neonatal Neuroimaging and Developmental Science Center, Department of Newborn Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA. FAU - Xie, Alex AU - Xie A AUID- ORCID: 0009-0005-5431-8764 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Kong, Xue-Jun AU - Kong XJ AUID- ORCID: 0000-0001-8551-8877 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. AD - Fetal-Neonatal Neuroimaging and Developmental Science Center, Department of Newborn Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA. AD - Department of Medicine and Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. LA - eng GR - 92436/Boston Children's Hospital/ GR - 233263/Massachusetts General Hospital/ PT - Journal Article DEP - 20260526 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Synbiotics/administration & dosage MH - *Metagenomics/methods MH - Child, Preschool MH - *Autism Spectrum Disorder/microbiology/therapy MH - Male MH - Child MH - Female MH - Pilot Projects MH - Feces/microbiology MH - *Gastrointestinal Microbiome MH - Treatment Outcome MH - *Precision Medicine/methods PMC - PMC13257912 OTO - NOTNLM OT - autism spectrum disorder OT - gut-brain axis OT - metagenomics OT - microbiota OT - personalized microbiome intervention OT - precision psychiatry OT - synbiotics COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/13 00:38 PMCR- 2026/05/26 CRDT- 2026/06/12 01:11 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/21 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - nu18111694 [pii] AID - nutrients-18-01694 [pii] AID - 10.3390/nu18111694 [doi] PST - epublish SO - Nutrients. 2026 May 26;18(11):1694. doi: 10.3390/nu18111694. PMID- 42280337 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 26 TI - Maternal Methyl-Group Donor Intake and Neonatal Birth Size in Singleton IVF Pregnancies. LID - 10.3390/nu18111693 [doi] LID - 1693 AB - Background/Objectives: Maternal intake of methyl-group donors (MGD) during pregnancy may influence fetal development, yet its role in in vitro fertilization (IVF) pregnancies remains poorly understood. The aim of the present study was to investigate maternal intake of MGDs during late pregnancy and its association with neonatal outcomes in IVF versus spontaneously (S) conceived pregnancies. Methods: We assessed third-trimester, daily maternal intake of MGD (folate, betaine, choline, methionine, and folic acid) using a validated food-frequency questionnaire, and maternal supplement intake using a structured questionnaire. Methyl-donor nutrient score (MDNS) was calculated based on deciles of MGD intake. Serum folic acid and vitamin B12 concentrations were measured using standardized immunochemical assay. Predefined inclusion and exclusion criteria were applied. Anthropometric data were measured from singleton newborns (weight, length, head- and waist circumference, body composition) and mothers (height, weight, body composition) after delivery. Statistical analysis was conducted using R (4.1.2v). Results: 265 mother-child pairs were included in the study (IVF n = 83). Daily dietary intake of MGDs was similar between groups, but IVF mothers reported significantly higher daily folic acid (668.7 +/- 1050.9 vs. 418.8 +/- 419.2 microg, p = 0.0034) and vitamin B12 (11.07 +/- 31.58 vs. 7.95 +/- 29.00 microg, p = 0.0078) supplementation. Serum analyses were available in a subgroup (n = 131, IVF n = 61) of mothers, showing higher postpartum folate (IVF: 10.96 +/- 5.54 vs. S: 8.29 +/- 4.72 microg/L, p = 0.0064) and vitamin B12 (IVF: 288.22 +/- 113.82 vs. S: 233.70 +/- 78.23 ng/L, p = 0.0053). Maternal daily dietary choline intakes were significantly below recommendations (IVF: 251.9 +/- 98.5 mg, S: 243.8 +/- 106.8 mg). Among 151 singleton neonates (IVF n = 57), anthropometric parameters did not differ between IVF and spontaneously conceived groups and were not associated with MDNS tertiles. Conclusions: Maternal MGD intake during third trimester of pregnancy was not associated with neonatal anthropometric outcomes in singleton pregnancies. Consistently low dietary choline intake highlights a potential nutritional gap warranting improved dietary guidance and supplementation strategies. FAU - Bokor, Szilvia AU - Bokor S AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Molecular Medicine Research Group, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Felso, Regina AU - Felso R AUID- ORCID: 0000-0001-5646-2093 AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Hungarian Centre of Genomics and Bioinformatics, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Csolle, Ildiko AU - Csolle I AUID- ORCID: 0000-0003-3582-2541 AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Cochrane Hungary, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Olah, Ticia AU - Olah T AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Szabo, Noemi AU - Szabo N AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Herczeg, Robert AU - Herczeg R AD - Hungarian Centre of Genomics and Bioinformatics, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Gyenesei, Attila AU - Gyenesei A AD - Hungarian Centre of Genomics and Bioinformatics, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Vass, Reka Anna AU - Vass RA AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Department of Obstetrics and Gynecology, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Funke, Simone AU - Funke S AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Department of Obstetrics and Gynecology, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Ertl, Tibor AU - Ertl T AUID- ORCID: 0000-0003-3650-7084 AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Department of Obstetrics and Gynecology, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Molnar, Denes AU - Molnar D AUID- ORCID: 0000-0002-3675-7019 AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Molecular Medicine Research Group, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. LA - eng PT - Journal Article DEP - 20260526 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 935E97BOY8 (Folic Acid) RN - N91BDP6H0X (Choline) RN - P6YC3EG204 (Vitamin B 12) RN - AE28F7PNPL (Methionine) RN - 3SCV180C9W (Betaine) SB - IM MH - Humans MH - Female MH - *Fertilization in Vitro MH - Pregnancy MH - Infant, Newborn MH - Adult MH - Folic Acid/administration & dosage/blood MH - *Birth Weight MH - Choline/administration & dosage MH - Vitamin B 12/blood/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - *Dietary Supplements MH - Methionine/administration & dosage MH - Betaine/administration & dosage MH - Pregnancy Trimester, Third MH - Diet PMC - PMC13259345 OTO - NOTNLM OT - choline OT - folic acid OT - in vitro fertilization OT - methyl-group donor OT - newborn COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/12 06:38 MHDA- 2026/06/15 11:35 PMCR- 2026/05/26 CRDT- 2026/06/12 01:11 PHST- 2026/03/20 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/06/15 11:35 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - nu18111693 [pii] AID - nutrients-18-01693 [pii] AID - 10.3390/nu18111693 [doi] PST - epublish SO - Nutrients. 2026 May 26;18(11):1693. doi: 10.3390/nu18111693. PMID- 42280306 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 22 TI - GLP-1 Receptor Agonists and Dual GIP/GLP-1 Receptor Agonists in Children and Adolescents with Obesity: Clinical Outcomes and the Impact of Nutritional and Behavioral Co-Interventions-A Systematic Review. LID - 10.3390/nu18111662 [doi] LID - 1662 AB - Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), originally developed for the treatment of type 2 diabetes (T2D), are increasingly used for the management of overweight and obesity in children and adolescents. However, the impact of concomitant lifestyle interventions, which vary in scope, structure, and intensity, remains unclear. Methods: A systematic search of PubMed, Scopus, and ClinicalTrials.gov was conducted from April to December 2025 (last update: 12 December 2025), in accordance with the PRISMA 2020 statement. Randomized and observational studies including patients aged 6-19 years with overweight or obesity, with or without T2D, treated with GLP-1 RAs or dual GIP/GLP-1 agonists, were included. Anthropometric outcomes, metabolic parameters, and the scope and structure of concomitant nutritional and behavioral interventions were assessed. Results: Fifteen studies (12 interventional [RCT/non-RCT] and 3 observational), including 1448 participants, were analyzed: liraglutide (n = 6), exenatide (n = 5), semaglutide (n = 1), dulaglutide (n = 1), tirzepatide (n = 1), and lixisenatide (n = 1). Intervention duration ranged from 6 to 68 weeks. Reported BMI reductions varied across studies and pharmacological agents, with semaglutide trials reporting reductions of up to -16.1%. Lifestyle interventions were heterogeneously reported, ranging from general dietary advice to structured, multidisciplinary programs including nutritional counseling, physical activity, and behavioral or family support. Due to heterogeneity in study design and reporting, the independent contribution of lifestyle interventions could not be determined. Conclusions: Available evidence suggests that GLP-1 RAs may represent an effective therapeutic option for children and adolescents with obesity and metabolic disorders. However, available evidence is largely derived from studies incorporating inconsistently reported lifestyle interventions, limiting the ability to disentangle pharmacological and lifestyle effects. Standardized reporting and studies specifically designed to assess their independent and combined effects are needed. Future research should standardize the reporting of lifestyle protocols (e.g., using TIDieR), incorporate validated measures of eating behavior, food preferences, and dietary intake, and use designs (e.g., factorial or stratified randomization of lifestyle intensity) that allow for the pharmacological and behavioral contributions to be quantified separately. This review highlights a critical and previously underexplored methodological gap regarding the structure and reporting of lifestyle co-interventions in pediatric GLP-1 trials. FAU - Mysliwczyk, Dominika AU - Mysliwczyk D AUID- ORCID: 0009-0004-2331-4106 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. FAU - Gofron, Krzysztof Ksawery AU - Gofron KK AD - Student Scientific Circle at Department of Clinical Nutrition, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. FAU - Wasilewski, Andrzej AU - Wasilewski A AUID- ORCID: 0000-0001-9908-6921 AD - Student Scientific Association of Medical Chemistry and Immunochemistry, Wroclaw Medical University, Marii Sklodowskiej-Curie 48/50, 59-369 Wroclaw, Poland. FAU - Mysliwiec, Malgorzata AU - Mysliwiec M AUID- ORCID: 0000-0002-1533-8544 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. FAU - Wasilewska, Eliza AU - Wasilewska E AUID- ORCID: 0000-0002-5288-0586 AD - Department of Allergology, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260522 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - WTT295HSY5 (dulaglutide) RN - 9P1872D4OL (Exenatide) RN - 59392-49-3 (Gastric Inhibitory Polypeptide) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 62340-29-8 (Glucagon-Like Peptides) RN - 839I73S42A (Liraglutide) RN - 74O62BB01U (lixisenatide) RN - 53AXN4NNHX (Semaglutide) RN - OYN3CCI6QE (Tirzepatide) RN - 0 (Immunoglobulin Fc Fragments) RN - 0 (Recombinant Fusion Proteins) RN - 89750-14-1 (Glucagon-Like Peptide 1) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Young Adult MH - *Behavior Therapy MH - Exenatide/therapeutic use MH - *Gastric Inhibitory Polypeptide/agonists MH - *Glucagon-Like Peptide-1 Receptor Agonists/therapeutic use MH - Glucagon-Like Peptides/analogs & derivatives/therapeutic use MH - Life Style MH - Liraglutide/therapeutic use MH - *Pediatric Obesity/therapy/drug therapy MH - Semaglutide/therapeutic use MH - Tirzepatide/therapeutic use MH - Treatment Outcome MH - Immunoglobulin Fc Fragments MH - Recombinant Fusion Proteins MH - Glucagon-Like Peptide 1/analogs & derivatives PMC - PMC13258732 OTO - NOTNLM OT - GLP-1 receptor agonists OT - adolescents OT - children OT - dulaglutide OT - exenatide OT - lifestyle intervention OT - liraglutide OT - nutritional counseling OT - pediatric obesity OT - semaglutide OT - systematic review OT - tirzepatide COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/13 00:38 PMCR- 2026/05/22 CRDT- 2026/06/12 01:11 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - nu18111662 [pii] AID - nutrients-18-01662 [pii] AID - 10.3390/nu18111662 [doi] PST - epublish SO - Nutrients. 2026 May 22;18(11):1662. doi: 10.3390/nu18111662. PMID- 42280305 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 22 TI - Methodological Approaches to Assess Disordered Eating Behaviors Related to Gluten-Free Diet Management in Children and Adolescents with Celiac Disease: A Scoping Review. LID - 10.3390/nu18111661 [doi] LID - 1661 AB - Objective: This scoping review aimed to map the methodological approaches used to assess disordered eating attitudes and behaviors in children and adolescents with celiac disease (CD). Methods: This review followed the Joanna Briggs Institute scoping review methodology and the PRISMA-ScR guidelines, including studies of children and adolescents with CD that used methodological approaches to assess disordered eating attitudes and behaviors in the context of the gluten-free diet (GFD). No restrictions were applied regarding geography, language, or year. Searches were conducted across 10 electronic databases. Data were descriptively analyzed and presented in tables or diagrams, with a narrative synthesis aligned to the review objective. Results: Studies from 13 countries were included and classified as quantitative (n = 16; 51.6%), qualitative (n = 11; 35.5%), or mixed-methods (n = 4; 12.9%). A total of 34 instruments were used, but only one was specifically designed to evaluate eating attitudes and behaviors in children and adolescents with CD. Conclusions: Analysis of disordered eating in children and adolescents with CD remains methodologically heterogeneous and evolving. Quantitative studies predominate but often rely on non-specific instruments that blur the distinction between adaptive dietary vigilance and disordered eating. Qualitative and mixed-methods approaches highlight lived experiences and reveal measurement gaps despite their higher costs. Progress depends on developing specific instruments for this population that better capture the complexity of GFD management across development. FAU - Schwantes, Marina de Cesaro AU - Schwantes MC AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Dusi, Rafaella AU - Dusi R AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Uenishi, Rosa Harumi AU - Uenishi RH AUID- ORCID: 0000-0002-2352-4355 AD - Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Ribeiro, Camila Dos Santos AU - Ribeiro CDS AUID- ORCID: 0000-0002-2770-1603 AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng GR - 00193-00000325/2026-83/Foundation for Research Support of the Federal District/ PT - Journal Article PT - Scoping Review DEP - 20260522 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Gluten-Free/psychology MH - *Celiac Disease/diet therapy/psychology MH - Adolescent MH - Child MH - *Feeding and Eating Disorders/diagnosis/psychology/etiology MH - *Feeding Behavior/psychology MH - Female MH - Male MH - Adolescent Behavior MH - Child Behavior PMC - PMC13258312 OTO - NOTNLM OT - behavioral nutrition OT - disordered eating OT - gluten-free diet OT - psychometrics COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/13 06:38 PMCR- 2026/05/22 CRDT- 2026/06/12 01:11 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/13 06:38 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - nu18111661 [pii] AID - nutrients-18-01661 [pii] AID - 10.3390/nu18111661 [doi] PST - epublish SO - Nutrients. 2026 May 22;18(11):1661. doi: 10.3390/nu18111661. PMID- 42279021 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 11 DP - 2026 May 28 TI - The ALT/AST Ratio as a Predictor of MASLD in Obese Children: A Comparative Analysis with Metabolic Indices Including HOMA-IR and TyG. LID - 10.3390/jcm15114160 [doi] LID - 4160 AB - Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is getting more prevalent in children with obesity, and simple and non-invasive biomarkers are needed for early detection. In this study, the discriminative performance of the ALT/AST ratio (AT index) for MASLD was evaluated in comparison with metabolic indices such as HOMA-IR and TyG derivatives. Methods: A total of 410 children with obesity aged 5-18 years were included in this prospective, multicenter cross-sectional study. Anthropometric measurements, laboratory data, and abdominal ultrasonography findings of the participants were evaluated. MASLD was diagnosed based on ultrasonographic findings. The discriminative performance of the indices was evaluated using ROC analysis, and factors independently associated with MASLD were assessed using multivariate logistic regression analysis. Results: BMI SDS, ALT, AT index, insulin, HOMA-IR, and TyG/ALT values were found to be significantly higher in the MASLD (+) group (p < 0.05). The AT index demonstrated statistically significant but modest discriminative ability for MASLD (AUC = 0.621; p < 0.001) and showed 70.5% sensitivity and 50.7% specificity at a cutoff value of >0.88. In the multivariate analysis, the AT index (OR: 3.401; 95% CI: 1.717-6.735; p < 0.001) and BMI SDS were identified as factors independently associated with MASLD.HOMA-IR and prolactin-related indices were not found to be significant as independent predictors. Conclusions: The ALT/AST ratio is a simple and accessible biomarker associated with MASLD in children with obesity. Although its discriminative performance is modest, its association with hepatic involvement and metabolic dysfunction suggests that it may provide supportive exploratory information in the evaluation of MASLD. However, further validation studies are required before broader clinical application. FAU - Kabukcu, Hilmi Onur AU - Kabukcu HO AUID- ORCID: 0000-0001-6869-9397 AD - Department of Pediatrics, Private Kastamonu Anatolia Hospital, 37200 Kastamonu, Turkey. FAU - Hazer, Ilhan AU - Hazer I AD - Department of Pediatric Endocrinology, Kutahya Health Sciences University, 43100 Kutahya, Turkey. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13257721 OTO - NOTNLM OT - AT index OT - MASLD OT - non-invasive biomarker COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/05/28 CRDT- 2026/06/12 01:06 PHST- 2026/05/06 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:06 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - jcm15114160 [pii] AID - jcm-15-04160 [pii] AID - 10.3390/jcm15114160 [doi] PST - epublish SO - J Clin Med. 2026 May 28;15(11):4160. doi: 10.3390/jcm15114160. PMID- 42278890 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 11 DP - 2026 May 22 TI - Cardiovascular Risk and Modifiable Risk Factors in Shift-Working Healthcare Workers: A Gender-Stratified Cross-Sectional Study. LID - 10.3390/jcm15114028 [doi] LID - 4028 AB - Background: Shift-working healthcare workers (HCWs) are at elevated cardiovascular (CV) risk due to chronic circadian disruption; however, gender-stratified data on CV risk profiles and modifiable risk factor distribution by occupational exposure duration remain scarce in the Italian hospital setting. This cross-sectional study aimed to characterise the 10-year CV risk profile and the distribution of modifiable risk factors in a hospital-based sample of shift-working HCWs. Methods: A retrospective cross-sectional study was conducted using data from routine occupational health surveillance of shift-working HCWs at a large Italian hospital in Salento, Southern Italy (survey year: 2025). The 10-year CV risk was estimated using the CUORE Project algorithm, validated for the Italian population. Risk was stratified by gender, age group, and shift work duration. Multivariable logistic regression models, adjusted for age, marital status, and presence of children at home, evaluated associations between selected risk factors and CV risk category. The study was reported in accordance with STROBE guidelines. Results: Of 765 HCWs included (320 males, 445 females; mean age 49.3 +/- 8.5 years), male workers showed a significantly higher mean 10-year CV risk score (4.98 +/- 2.8 vs. 1.34 +/- 0.9; p < 0.05). Among male workers, the odds of moderate/high CV risk increased progressively with shift work duration (aOR 6.4 for >30 years). Males also showed significantly higher prevalence of arterial hypertension, overweight, and obesity across all strata. Conclusions: Male shift-working HCWs represent a higher-risk subgroup, characterised by a greater burden of modifiable cardiovascular risk factors. Integration of validated risk assessment tools into occupational health surveillance may support targeted preventive strategies in hospital settings. FAU - d'Ettorre, Gabriele AU - d'Ettorre G AUID- ORCID: 0000-0001-8714-1612 AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Giannelli, Gianmarco AU - Giannelli G AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Branda, Francesco AU - Branda F AUID- ORCID: 0000-0002-9485-3877 AD - Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, 00128 Rome, Italy. FAU - Loiacono, Giuseppe AU - Loiacono G AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Calcagnile, Gianluigi AU - Calcagnile G AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Centonze, Anna A AU - Centonze AA AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Faggiano, Danilo AU - Faggiano D AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - d'Ettorre, Gabriella AU - d'Ettorre G AUID- ORCID: 0000-0002-3571-5677 AD - Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00185 Rome, Italy. FAU - Ceccarelli, Giancarlo AU - Ceccarelli G AUID- ORCID: 0000-0001-5921-3180 AD - Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00185 Rome, Italy. LA - eng PT - Journal Article DEP - 20260522 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13258224 OTO - NOTNLM OT - Italy OT - cardiovascular risk OT - cross-sectional study OT - healthcare workers OT - shift work COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/05/22 CRDT- 2026/06/12 01:06 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:06 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - jcm15114028 [pii] AID - jcm-15-04028 [pii] AID - 10.3390/jcm15114028 [doi] PST - epublish SO - J Clin Med. 2026 May 22;15(11):4028. doi: 10.3390/jcm15114028. PMID- 42278755 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 11 DP - 2026 May 28 TI - Iterative Adaptations in a Physical Activity Program for Children with Autism: A Feasibility and Implementation Study. LID - 10.3390/healthcare14111502 [doi] LID - 1502 AB - Background: Children and adolescents with autism spectrum disorder (ASD) are generally more sedentary and engage less in physical activity (PA) than their peers. Despite increasing evidence of benefits, practical guidance on implementing adapted PA programs in real-world settings remains limited. This study aimed to document iterative adaptations, implementation processes, and participant experiences in a structured PA intervention for children with ASD. Methods: Nineteen children aged 10-14 years with ASD participated in an adapted PA intervention delivered across three cohorts. The program was progressively modified based on observed barriers and participant feedback. Post-intervention conversations with participants and/or parents were used to assess feasibility and experiences. Results: Most participants trained on-site in small groups and were predominantly boys, many with comorbid ADHD/ADD. Baseline engagement in organized PA was low. Adaptations included adjustments to session structure, group size, instructor-to-participant ratio, and activity content to enhance predictability and autonomy. Individual tailoring and flexible delivery were essential to accommodate neurodevelopmental diversity and fluctuating motivation. Post-intervention feedback suggested generally positive acceptability, while findings should be interpreted descriptively. Conclusions: This study provides preliminary, practice-based insights into how structured PA programs may be iteratively adapted for children with ASD in a supportive clinical context. The findings highlight practical considerations for implementing adapted PA in clinical and community settings. FAU - Richter, Miriam AU - Richter M AD - Division of Clinical Neurophysiology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. AD - Division of Child and Adolescent Psychiatry, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. AD - Clinical Neurophysiology, Department of Medical Imaging and Physiology, Skane University Hospital, SE-221 85 Lund, Sweden. FAU - Taylor, Marie K AU - Taylor MK AUID- ORCID: 0000-0001-9391-1070 AD - Division of Clinical Neurophysiology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. AD - Clinical Neurophysiology, Department of Medical Imaging and Physiology, Skane University Hospital, SE-221 85 Lund, Sweden. AD - Epilepsy Center, Department of Clinical Sciences, Lund University, SE-221 85 Lund, Sweden. FAU - Lindstedt, Teresa AU - Lindstedt T AD - Division of Pediatrics, Skane University Hospital, SE-221 84 Lund, Sweden. FAU - Lundkvist Josenby, Annika AU - Lundkvist Josenby A AUID- ORCID: 0000-0001-9694-9349 AD - Division of Pediatrics, Skane University Hospital, SE-221 84 Lund, Sweden. AD - Department of Health Sciences, Lund University, SE-221 85 Lund, Sweden. FAU - Rask, Olof AU - Rask O AUID- ORCID: 0000-0003-0565-3812 AD - Division of Child and Adolescent Psychiatry, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. FAU - Ekdahl, Christine T AU - Ekdahl CT AUID- ORCID: 0000-0002-1894-1955 AD - Division of Clinical Neurophysiology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. AD - Clinical Neurophysiology, Department of Medical Imaging and Physiology, Skane University Hospital, SE-221 85 Lund, Sweden. AD - Epilepsy Center, Department of Clinical Sciences, Lund University, SE-221 85 Lund, Sweden. LA - eng GR - Tore Nilsson Stiftelse for Medicinsk forskning/ GR - RSID 130567/Swedish medical ALF grant/ PT - Journal Article DEP - 20260528 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13256154 OTO - NOTNLM OT - adapted physical activity OT - autism spectrum disorder OT - feasibility study OT - implementation OT - physical activity COIS- The authors declare no conflict of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/05/28 CRDT- 2026/06/12 01:05 PHST- 2026/04/02 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:05 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - healthcare14111502 [pii] AID - healthcare-14-01502 [pii] AID - 10.3390/healthcare14111502 [doi] PST - epublish SO - Healthcare (Basel). 2026 May 28;14(11):1502. doi: 10.3390/healthcare14111502. PMID- 42278753 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 11 DP - 2026 May 28 TI - Inter-Arm Blood Pressure Differences and Handgrip Strength in Youth Athletes: Implications for Early Cardiovascular Screening. LID - 10.3390/healthcare14111500 [doi] LID - 1500 AB - Background: Inter-arm blood pressure difference (IAD) >/= 10 mmHg is an established marker of cardiovascular risk in adults; however, evidence in paediatric populations remains limited. Handgrip strength (HGS) is increasingly recognized as a simple and reliable indicator of neuromuscular fitness and cardiometabolic health during growth and development. Objectives: We aimed to investigate the association between IAD and HGS in children and adolescent athletes and to explore the influence of anthropometric characteristics. Methods: Forty-one non-professional athletes aged 6-16 years participated in this cross-sectional study. Anthropometric characteristics, bilateral resting BP, and bilateral HGS were assessed using standardized protocols. Inter-arm differences in systolic and diastolic BP were calculated. Results: An inter-arm systolic BP difference >/= 10 mmHg was observed in 12.2% of participants. Dominant-arm systolic BP and HGS were significantly higher compared with the non-dominant side (p < 0.05). HGS showed a positive association with systolic BP, particularly in boys, whereas weaker associations were observed with diastolic BP. In regression analysis, BMI emerged as a significant predictor of systolic blood pressure. Conclusions: In young athletes, dominant-arm superiority in both muscular strength and systolic BP was evident. Bilateral BP assessment combined with HGS measurement may provide information during cardiovascular evaluation paediatric athletic populations. FAU - Pepera, Garyfallia AU - Pepera G AUID- ORCID: 0000-0001-8012-0325 AD - Clinical Exercise Physiology and Rehabilitation Research Laboratory, Department of Physiotherapy, Faculty of Health Sciences, University of Thessaly, 35132 Lamia, Greece. FAU - Piperopoulou, Chrysanthi AU - Piperopoulou C AD - Clinical Exercise Physiology and Rehabilitation Research Laboratory, Department of Physiotherapy, Faculty of Health Sciences, University of Thessaly, 35132 Lamia, Greece. FAU - Karagianni, Eleni AU - Karagianni E AUID- ORCID: 0009-0004-6978-9908 AD - Clinical Exercise Physiology and Rehabilitation Research Laboratory, Department of Physiotherapy, Faculty of Health Sciences, University of Thessaly, 35132 Lamia, Greece. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13257307 OTO - NOTNLM OT - adolescents OT - athletes OT - children OT - handgrip strength OT - inter-arm blood pressure difference COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/05/28 CRDT- 2026/06/12 01:05 PHST- 2026/04/19 00:00 [received] PHST- 2026/05/23 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:05 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - healthcare14111500 [pii] AID - healthcare-14-01500 [pii] AID - 10.3390/healthcare14111500 [doi] PST - epublish SO - Healthcare (Basel). 2026 May 28;14(11):1500. doi: 10.3390/healthcare14111500. PMID- 42277916 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260818 LR - 20260819 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Jun 11 TI - Protocol for the Southeast Asian Healthy Habits, Healthy Kids (SEAHK) study, a culturally tailored family-based pilot randomized controlled trial to improve dietary quality. LID - 10.1186/s40814-026-01863-1 [doi] LID - 118 AB - BACKGROUND: Southeast Asian (SEA) children are burdened by high rates of diet-related chronic conditions and diseases. These burdens partly result from socioeconomic disadvantages and refugee migration trajectories. Yet, to our knowledge, no dietary interventions exist for this population. This protocol paper describes the rationale, study design, intervention and study evaluation for the SEA Healthy Habits, Healthy Kids Study. METHODS: The study enrollment goal was 75 parent-child dyads recruited in Providence, Rhode Island, in the United States. A SEA parent/guardian and one of their 6-to-11-year-old children were randomized to (1) a monthly financial incentive only group; (2) an enhanced financial incentive group that receives additional interventions including family-based group nutrition education, three motivational interviewing (MI) phone calls, and weekly text messages on healthy eating norms and other nutrition topics; or (3) a structurally equivalent attention-matched control group. The primary study goals were to assess feasibility and acceptability, conduct process evaluation to determine implementation fidelity and intervention dose, and determine preliminary efficacy. Feasibility was assessed based on attendance (primary) and secondary measures, recruitment, enrollment, intervention dose, and retention at 6 months. Acceptability was measured using satisfaction questionnaires on study favorability. Preliminary efficacy (i.e., comparing changes in children's diet quality (Healthy Eating Index and dermal carotenoids)) will be determined via longitudinal mixed effects models. Regression models will investigate the relationship between dose, implementation measures and study outcomes. RESULTS: This intervention received Institutional Review Board approval on February 16, 2023. We conducted intervention development from July 2022 to August 2022 with 62 SEA parents and children. For the intervention, we began participant recruitment in April 2023, which concluded January 2025. DISCUSSION: This study will demonstrate whether a culturally tailored healthy eating intervention for SEA families is feasible and acceptable and whether it leads to changes on key efficacy indicators. The intervention is informed by theories and frameworks relevant for the population and utilizes a family-centered approach. If this innovative pilot intervention achieves the study objectives, then we will refine it and pursue a larger randomized control trial. TRIAL REGISTRATION: This study is registered at ClinicalTrials.gov under registration number NCT05817838. The trial was registered on April 17, 2023. The trial registry record is available at https://clinicaltrials.gov/study/NCT05817838 . CI - (c) 2026. The Author(s). FAU - Dulin, Akilah AU - Dulin A AUID- ORCID: 0000-0002-0769-1014 AD - Department of Social, Behavioral and Population Sciences, Tulane University, Celia Scott Weatherhead School of Public Health, 1400 Canal St, New Orleans, LA, 70112, USA. adulin@tulane.edu. FAU - Tovar, Alison AU - Tovar A AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, 02903, USA. FAU - Dunsiger, Shira AU - Dunsiger S AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, 02903, USA. AD - Department of Biostatistics, Brown University School of Public Health, Providence, RI, 02903, USA. FAU - Carey, Kate B AU - Carey KB AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, 02903, USA. FAU - Gans, Kim M AU - Gans KM AD - Department of Biostatistics, Brown University School of Public Health, Providence, RI, 02903, USA. AD - Department of Human Development and Family Sciences, University of Connecticut, Storrs, CT, 06269, USA. LA - eng SI - ClinicalTrials.gov/NCT05817838 GR - R01 DK128197/DK/NIDDK NIH HHS/United States GR - 5R01DK128197/DK/NIDDK NIH HHS/United States GR - 5R01DK128197/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260611 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13479714 OTO - NOTNLM OT - Diet OT - Family OT - Intervention study OT - Southeast Asian people OT - Type 2 diabetes COIS- Declarations. Ethics approval and consent to participate : This study received approval from the Brown University Institutional Review Board (protocol 2022003499). All adult participants provided informed consent (verbal or written) and children provided assent to participate. Consent for publication: This is included as part of the participant consent and assent forms. Competing interests : The authors declare that they do not have any financial competing interests in the study. Author AD is a long-time board member of the community partner organization where the study is occurring, and has provided continuous, in-kind support for the past 12 years. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/06/11 CRDT- 2026/06/12 00:57 PHST- 2025/01/12 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 00:57 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.1186/s40814-026-01863-1 [pii] AID - 1863 [pii] AID - 10.1186/s40814-026-01863-1 [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Jun 11;12(1):118. doi: 10.1186/s40814-026-01863-1. PMID- 42277906 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260818 LR - 20260820 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Jun 11 TI - Determinants and district-level variation in childhood undernutrition in Sindh, Pakistan: evidence from MICS 2018. LID - 10.1186/s40795-026-01391-4 [doi] LID - 170 AB - BACKGROUND: Childhood undernutrition remains a persistent public health challenge in low- and middle-income countries, particularly in South Asia. In Pakistan, both chronic (stunting) and acute (wasting) forms of undernutrition continue to affect a substantial proportion of children. Sindh province faces pronounced socioeconomic, environmental, and health-related disparities that may influence child nutritional outcomes. This study aimed to examine the determinants of stunting and wasting among children aged 0-23 months and to assess district-level variations using Sindh Multiple Indicator Cluster Survey (MICS) 2018 data. METHODS: This cross-sectional study utilized secondary data from MICS 2018, including 5,985 children with valid anthropometric measurements. Stunting and wasting were defined as height-for-age z-score (HAZ) and weight-for-height z-score (WHZ) below - 2 standard deviations, respectively, based on WHO standards. Analyses were conducted using the complex samples module in SPSS to account for sampling weights, clustering, and stratification. Weighted descriptive statistics were computed, and bivariate associations were assessed using the Rao-Scott chi-square test. Multivariable logistic regression models were applied to identify determinants, with adjusted odds ratios (AORs) and 95% confidence intervals (CIs) reported. District-level prevalence estimates were also generated. RESULTS: The prevalence of stunting and wasting was 38.4% and 17.4%, respectively. In bivariate analysis, both outcomes increased with age; however, after adjustment, younger children aged 0-5 months exhibited significantly lower odds of wasting compared with children aged 12-23 months, indicating comparatively higher odds among older children. Household socioeconomic status was significantly associated with stunting, with children from poorer households having significantly higher odds. Access to improved drinking water was associated with reduced odds of stunting (AOR = 0.70; 95% CI: 0.49-0.98). Male children showed relatively higher odds of wasting, although the association was not statistically significant after adjustment. while other factors, including sanitation, feeding practices, and recent illness, were not statistically significant after adjustment. The apparent association between vaccination and wasting observed in bivariate analysis was attenuated in multivariable analysis, suggesting confounding, particularly by child age. Substantial district-level disparities were observed, with higher burdens in interior districts compared to urban areas. CONCLUSION: Childhood undernutrition remains a significant concern in Sindh, with distinct determinants for stunting and wasting. Socioeconomic inequalities and environmental conditions remain important factors associated with childhood under nutrition. While geographic disparities highlight the need for targeted, context-specific interventions. Strengthening nutrition programs with a focus on vulnerable populations and high-burden districts is essential to reduce undernutrition in the province. CI - (c) 2026. The Author(s). FAU - Mahar, Benazir AU - Mahar B AD - Department of Community Health, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. beenafs@hotmail.com. FAU - Shah, Tazeen AU - Shah T AD - Department of Physiology, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Sindh, Pakistan. FAU - Rajpoot, Noor Nasir AU - Rajpoot NN AD - Holy Family Hospital, Rawalpindi, Punjab, Pakistan. FAU - Sadiq, Noman AU - Sadiq N AD - Department of Physiology, Mekran Medical College, Baluchistan, Pakistan. FAU - Ansari, Muhammad Ali AU - Ansari MA AD - Health Department, Sindh, Pakistan. FAU - Ali, Shazia AU - Ali S AD - Jinnah Postgraduate Medical Center Karachi, Karachi, Pakistan. FAU - Rai, Dalpat AU - Rai D AD - Civil Hospital Mithi, Tharparkar, Pakistan. LA - eng PT - Journal Article DEP - 20260611 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13483532 OTO - NOTNLM OT - Children under two years OT - Determinants OT - Geographic variation OT - Multiple Indicator Cluster Survey (MICS) OT - Pakistan OT - Public health nutrition OT - Sindh OT - Socioeconomic factors OT - Stunting OT - Wasting COIS- Declarations. Ethics approval and consent to participate: The study used publicly available secondary data; therefore, ethical approval and informed consent were not required. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/06/11 CRDT- 2026/06/12 00:56 PHST- 2026/04/13 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 00:56 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.1186/s40795-026-01391-4 [pii] AID - 1391 [pii] AID - 10.1186/s40795-026-01391-4 [doi] PST - epublish SO - BMC Nutr. 2026 Jun 11;12(1):170. doi: 10.1186/s40795-026-01391-4. PMID- 42277719 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260909 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Jun 11 TI - Machine learning-based prediction of bronchiolitis in children under two years: a multicenter study within a single metropolitan area. LID - 10.1186/s12879-026-13802-9 [doi] LID - 1516 AB - BACKGROUND: Bronchiolitis is a leading cause of hospitalization in infants, yet early and accurate risk prediction remains a clinical challenge. Traditional models often lack the complexity to capture nonlinear interactions or the transparency required for clinical trust. OBJECTIVE: This multicenter study aimed to develop, validate, and interpret machine learning (ML) models for predicting bronchiolitis risk in children under two years of age using clinical and socioeconomic determinants. METHODS: In this retrospective study, data from 1,260 children (529 with bronchiolitis and 731 without) were collected at 5 pediatric centers within a single metropolitan area, from January 2023 through December 2024. Seventeen predictors were analyzed. After rigorous preprocessing and K-NN imputation, eight ML algorithms, including four base learners and four ensemble methods, were developed. Model performance was evaluated using AUC and metrics derived from confusion matrices. Clinical utility was assessed via Decision Curve Analysis (DCA) and calibration plots. Explainable AI (XAI) was implemented using Shapley Additive exPlanations (SHAP) to interpret model decisions. RESULTS: XGBoost achieved an AUC of 0.863 [0.828-0.897] in the test set, demonstrating higher predictive performance than base learners such as NB (AUC: 0.583 [0.529-0.638]). DCA and calibration plots confirmed that XGBoost provides superior net benefit and calibration performance across a range of threshold probabilities. SHAP analysis identified overcrowding, severe acute malnutrition, and maternal smoking as the most influential predictors, highlighting the critical role of socioeconomic and environmental factors in disease susceptibility. CONCLUSION: The integration of XGBoost with SHAP values provides a robust, transparent, and clinically actionable framework for early prediction of bronchiolitis based on variables available at initial clinical presentation. By identifying high-risk infants through interpretable AI, this model supports early triage and optimized resource allocation, fostering the transition toward precision pediatric medicine. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Nopour, Raoof AU - Nopour R AUID- ORCID: 0000-0003-3770-2375 AD - Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. nopour.r70@gmail.com. FAU - Barzegari, Saeed AU - Barzegari S AD - Department of Paramedicine, Amol School of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran. FAU - Shanbehzadeh, Mostafa AU - Shanbehzadeh M AD - Department of Health Information Technology, School of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran. FAU - Mahmoudvand, Zahra AU - Mahmoudvand Z AD - Department of Health Information Technology, School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260611 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Humans MH - *Bronchiolitis/diagnosis/epidemiology MH - Retrospective Studies MH - Infant MH - *Machine Learning MH - Predictive Learning Models MH - Female MH - Boosting Machine Learning Algorithms MH - Male MH - Prediction Algorithms MH - Classification Algorithms MH - Infant, Newborn MH - Hospitalization MH - Algorithms PMC - PMC13483499 OTO - NOTNLM OT - Bronchiolitis OT - Explainable AI OT - Machine learning OT - Pediatric triage OT - SHAP OT - Socioeconomic determinants OT - XGBoost COIS- Declarations. Ethics approval and consent to participate: This study was approved by the ethics committee of the Mazandaran University of Medical Sciences (IR.MAZUMS.REC.1405.023). Ethical approval was obtained from the investigators' affiliated institution (Mazandaran University of Medical Sciences), although data collection was conducted at collaborating pediatric centers in Tehran. All methods were carried out in accordance with relevant guidelines and regulations. Informed consent was obtained from all subjects and/or their legal guardian(s). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/12 06:39 MHDA- 2026/08/19 14:49 PMCR- 2026/06/11 CRDT- 2026/06/12 00:47 PHST- 2026/04/29 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/08/19 14:49 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 00:47 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.1186/s12879-026-13802-9 [pii] AID - 13802 [pii] AID - 10.1186/s12879-026-13802-9 [doi] PST - epublish SO - BMC Infect Dis. 2026 Jun 11;26(1):1516. doi: 10.1186/s12879-026-13802-9. PMID- 42276999 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260824 IS - 2041-1723 (Electronic) IS - 2041-1723 (Linking) VI - 17 IP - 1 DP - 2026 Jun 11 TI - Benchmarking large language models for cell-free RNA diagnostic biomarker discovery. LID - 10.1038/s41467-026-74077-x [doi] LID - 7429 AB - Large language models can synthesize biomedical knowledge, parse vast amounts of data, and generate code, positioning them as promising tools for biomarker discovery from high-throughput omics data. Here, we benchmark six models from OpenAI, Anthropic, and Google on plasma cell-free RNA datasets spanning three clinical cohorts: Kawasaki disease versus multisystem inflammatory syndrome in children, active tuberculosis versus symptomatic respiratory controls, and myalgic encephalomyelitis/chronic fatigue syndrome versus sedentary controls. We evaluate literature-guided nomination of diagnostic gene panels for downstream machine learning and autonomous construction of end-to-end classifiers from raw count matrices to held-out test predictions. Despite prompt adherence issues, model-nominated panels recapitulate canonical immune pathways and outperform random panels across cohorts, even matching differential gene expression baselines in the tuberculosis cohort. End-to-end automation proves feasible but is model- and task-dependent. One model approaches conventional performance for Kawasaki disease versus multisystem inflammatory syndrome in children, whereas performance decreases for tuberculosis and myalgic encephalomyelitis/chronic fatigue syndrome cohorts. These findings delineate current capabilities and limitations of large language models in diagnostics and open a path for their future use in biomarker discovery. CI - (c) 2026. The Author(s). FAU - Gaudio, Hunter A AU - Gaudio HA AUID- ORCID: 0000-0002-3104-8467 AD - Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. FAU - Bliss, Andrew AU - Bliss A AUID- ORCID: 0009-0008-1811-3878 AD - Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. FAU - Loy, Conor J AU - Loy CJ AD - Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. FAU - Eweis-LaBolle, Daniel AU - Eweis-LaBolle D AUID- ORCID: 0000-0001-7599-6082 AD - Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. FAU - Gardella, Anne E AU - Gardella AE AUID- ORCID: 0000-0003-1860-8316 AD - Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. FAU - De Vlaminck, Iwijn AU - De Vlaminck I AUID- ORCID: 0000-0001-6085-7311 AD - Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. vlaminck@cornell.edu. LA - eng GR - R21 AI173979/AI/NIAID NIH HHS/United States GR - R01AI151059/U.S. Department of Health & Human Services | National Institutes of Health (NIH)/ GR - R01AI192977/U.S. Department of Health & Human Services | National Institutes of Health (NIH)/ GR - R01 AI146165/AI/NIAID NIH HHS/United States GR - R21AI173979/U.S. Department of Health & Human Services | National Institutes of Health (NIH)/ GR - R01 AI192977/AI/NIAID NIH HHS/United States GR - R01 AI151059/AI/NIAID NIH HHS/United States GR - R01AI146165/U.S. Department of Health & Human Services | National Institutes of Health (NIH)/ PT - Journal Article DEP - 20260611 PL - England TA - Nat Commun JT - Nature communications JID - 101528555 RN - 0 (Biomarkers) RN - 0 (Cell-Free Nucleic Acids) SB - IM MH - Humans MH - *Biomarkers/blood MH - *Large Language Models MH - *Cell-Free Nucleic Acids/blood/genetics MH - Benchmarking MH - Mucocutaneous Lymph Node Syndrome/diagnosis/genetics/blood MH - Tuberculosis/diagnosis/genetics MH - Child PMC - PMC13408832 COIS- Competing interests: I.D.V. is listed as an inventor on submitted patents pertaining to cell-free nucleic acids (US patent applications 63/237,367, 63/429,733, 63/056,249, 63/015,095, 16/500,929, 41614P-10551-01-US). I.D.V. is a member of the Scientific Advisory Board of Karius Inc. and a co-founder and advisor for Kanvas Biosciences and Romix Biosciences. C.J.L. is the CEO and co-founder of Romix Biosciences. The remaining authors declare no competing interests. EDAT- 2026/06/12 00:37 MHDA- 2026/07/30 12:43 PMCR- 2026/06/11 CRDT- 2026/06/11 23:24 PHST- 2025/08/20 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/07/30 12:43 [medline] PHST- 2026/06/12 00:37 [pubmed] PHST- 2026/06/11 23:24 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.1038/s41467-026-74077-x [pii] AID - 74077 [pii] AID - 10.1038/s41467-026-74077-x [doi] PST - epublish SO - Nat Commun. 2026 Jun 11;17(1):7429. doi: 10.1038/s41467-026-74077-x. PMID- 42275809 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) VI - 22 IP - 5 DP - 2026 Oct TI - Quality of life and gender identity in females with congenital adrenal hyperplasia after genital restoration surgery: A single-center experience. PG - 106051 LID - S1477-5131(26)00330-X [pii] LID - 10.1016/j.jpurol.2026.106051 [doi] AB - BACKGROUND: Legislation restricting surgical interventions in children with differences of sex development (DSD) has intensified debate about female genital restoration surgery (FGRS) in patients with congenital adrenal hyperplasia (CAH). Long-term patient-reported outcomes are needed regarding the optimal timing of surgery. OBJECTIVE: We aimed to assess health-related quality of life (HRQoL), gender identity, and family satisfaction regarding surgical timing and outcome in females with CAH following genital restoration surgery. STUDY DESIGN: Cross-sectional survey of CAH patients who underwent surgery between January 2007 to December 2016 at our institution. Validated instruments (KINDL questionnaire for HRQoL, Utrecht Gender Dysphoria Scale, UGDS) and structured telephone interviews were employed. RESULTS: Data on HRQoL was available for 25 patients (self- and/or parent-reported) out of 56 eligible patients (45% response rate). Median age at first surgery was 6 months (range: 3-137 months). Patients' age at time of participation ranged from 2 to 28 years. All had 21-hydroxylase deficiency (92% salt-wasting form) with Prader grades ranging from II-V. Wound dehiscence requiring secondary suturing occurred in 15% of patients with primary surgery at our center, while only one (4%) patient developed vaginal stenosis after early primary vaginoplasty. Two additional patients (8%) with prior outside surgery required vaginal revision after FGRS at age 12. HRQoL scores were comparable to healthy reference populations across most age groups. Children aged 3-6 and adolescents and young adults showed no significant difference from reference values, while children aged 7-13 showed a slight elevation. None of five patients >/=14 years demonstrated gender dysphoria (all UGDS scores <40, threshold >/=40). 14 patients and families were also interviewed by telephone. All preferred early surgical timing. No family expressed regret about the decision or preferred delayed surgery. DISCUSSION: This study provides validated intermediate-term patient- and parent-reported outcomes after FGRS in CAH. Key limitations include the small sample size, single-center design, and young age of most patients. Selection bias may exist, though participating families included those who underwent revision surgery. The absence of a non-operated comparison group reflects current clinical reality, as nearly all CAH patients with urogenital sinus underwent surgical correction. CONCLUSIONS: Females with CAH reported normal HRQoL and a comfortable female gender identity after early FGRS. The patients and their families expressed a preference for early surgery. However, there is need for longer-term follow-up to assess sexual function and reproductive outcomes as well comparison of outcomes with a non-operated group. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Heidtmann, Friederike AU - Heidtmann F AD - Department of Pediatric Surgery, Jena University Hospital, 07747 Jena, Germany. Electronic address: friederike.heidtmann@med.uni-jena.de. FAU - Umbreit, Saskia AU - Umbreit S AD - Department of Pediatric Surgery, Jena University Hospital, 07747 Jena, Germany. Electronic address: saskia.umbreit@live.de. FAU - Eckoldt, Felicitas AU - Eckoldt F AD - Department of Pediatric Surgery, Jena University Hospital, 07747 Jena, Germany. Electronic address: felicitas.eckoldt@med.uni-jena.de. LA - eng PT - Journal Article DEP - 20260530 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM MH - Humans MH - Female MH - *Adrenal Hyperplasia, Congenital/surgery/psychology MH - Cross-Sectional Studies MH - Child MH - *Quality of Life MH - Adolescent MH - Child, Preschool MH - Adult MH - *Gender Identity MH - Young Adult MH - Infant MH - *Genitalia, Female/surgery MH - Gender Dysphoria MH - Treatment Outcome MH - *Plastic Surgery Procedures/methods MH - Retrospective Studies OTO - NOTNLM OT - Congenital adrenal hyperplasia OT - Female genital restoration surgery OT - Gender dysphoria OT - Patient reported outcomes OT - Quality of life OT - Urogenital sinus COIS- Conflict of interest statement None. EDAT- 2026/06/12 00:37 MHDA- 2026/09/01 05:41 CRDT- 2026/06/11 18:04 PHST- 2026/01/14 00:00 [received] PHST- 2026/04/26 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/09/01 05:41 [medline] PHST- 2026/06/12 00:37 [pubmed] PHST- 2026/06/11 18:04 [entrez] AID - S1477-5131(26)00330-X [pii] AID - 10.1016/j.jpurol.2026.106051 [doi] PST - ppublish SO - J Pediatr Urol. 2026 Oct;22(5):106051. doi: 10.1016/j.jpurol.2026.106051. Epub 2026 May 30. PMID- 42275593 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2359-4292 (Electronic) IS - 2359-3997 (Print) IS - 2359-3997 (Linking) VI - 70 IP - 4 DP - 2026 Jun 10 TI - Age-related changes in METS-IR and HOMA-IR in obese adults and their relationship with cardiometabolic comorbidities. LID - 10.20945/2359-4292-2026-0059 [doi] LID - e260059 AB - OBJECTIVE: Insulin resistance (IR) is central to cardiometabolic risk in obesity, but the clinical utility of IR indices may vary by age. We compared homeostasis model assessment for insulin resistance (HOMA-IR) and metabolic score for insulin resistance (METS-IR) across age groups in obese adults and examined comorbidity burden and discriminatory performance for type 2 diabetes mellitus (T2DM) and hypertension (HT). SUBJECTS AND METHODS: This retrospective, single-center study included adults with a BMI >/= 30 kg/m2 (n = 481) across four age strata (18-40, 40-65, 65-75, and >/=75 years). Spearman correlation assessed the association between HOMA-IR and METS-IR. Comorbidity burden (0-3 chronic conditions) was modeled using ordinal logistic regression per 1-SD increase in z-scores, adjusted for age, sex, and BMI. Receiver operating characteristic analysis and multivariable logistic regression assessed T2DM and HT. RESULTS: HOMA-IR and METS-IR were moderately correlated (rho = 0.342 and p < 0.001, respectively). METS-IR was associated with comorbidity burden (adjusted odds ratio [OR] 1.84; 95% confidence interval [CI] 1.26-2.69; p < 0.01), whereas HOMA-IR was not (OR 1.12; 95% CI 0.92-1.36; p = 0.256). Discriminatory performance was limited for T2DM (area under curve [AUC] 0.500 vs. 0.537) and HT (AUC 0.471 vs. 0.519). METS-IR remained associated with T2DM (OR 2.51; 95% CI 1.60-3.93; p < 0.001) and HT (OR 1.81; 95% CI 1.13-2.91; p < 0.05). CONCLUSION: In obese adults, METS-IR demonstrated a stronger association with comorbidity burden than HOMA-IR. However, because both indices showed limited discriminatory performance for T2DM and HT, they should not be used as standalone tools for treatment guidance or diagnostic classification. Rather, they should be interpreted alongside age, clinical, and biochemical findings, as isolated use may be misleading and fail to identify disease in specific patient subgroups. FAU - Timurkaan, Esra Suay AU - Timurkaan ES AUID- ORCID: 0000-0001-5654-7070 AD - Department of Internal Medicine Clinic, Fethi Sekin City Hospital, Elazig, Turkey. FAU - Altuntas, Gulsum AU - Altuntas G AUID- ORCID: 0000-0002-2673-8594 AD - Department of Intensive Care Clinic, Firat University, Elazig, Turkey. FAU - Uslu, Muhammed Fuad AU - Uslu MF AUID- ORCID: 0000-0001-6300-5130 AD - Department of Internal Medicine Clinic, Fethi Sekin City Hospital, Elazig, Turkey. FAU - Ayyildiz, Hakan AU - Ayyildiz H AUID- ORCID: 0000-0002-3133-9862 AD - Department of Internal Medicine Clinic, Fethi Sekin City Hospital, Elazig, Turkey. FAU - Timurkaan, Mustafa AU - Timurkaan M AUID- ORCID: 0000-0003-1950-0489 AD - Department of Internal Medicine Clinic, Fethi Sekin City Hospital, Elazig, Turkey. LA - eng PT - Journal Article DEP - 20260610 PL - Brazil TA - Arch Endocrinol Metab JT - Archives of endocrinology and metabolism JID - 101652058 SB - IM MH - Humans MH - Female MH - *Insulin Resistance/physiology MH - Male MH - Retrospective Studies MH - *Obesity/metabolism/complications/epidemiology MH - Middle Aged MH - *Diabetes Mellitus, Type 2/epidemiology/metabolism MH - Aged MH - Adult MH - Comorbidity MH - Age Factors MH - *Hypertension/epidemiology/metabolism MH - *Metabolic Syndrome/epidemiology/metabolism MH - Young Adult MH - Adolescent MH - Body Mass Index MH - Homeostasis PMC - PMC13327391 OTO - NOTNLM OT - HOMA-IR OT - METS-IR OT - comorbidity burden. OT - insulin resistance OT - obesity COIS- Disclosure: no potential conflict of interest relevant to this article was reported. EDAT- 2026/06/11 18:35 MHDA- 2026/06/13 00:38 PMCR- 2026/06/08 CRDT- 2026/06/11 15:26 PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/11 18:35 [pubmed] PHST- 2026/06/11 15:26 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.20945/2359-4292-2026-0059 [doi] PST - epublish SO - Arch Endocrinol Metab. 2026 Jun 10;70(4):e260059. doi: 10.20945/2359-4292-2026-0059. PMID- 42275030 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261005 IS - 1930-7810 (Electronic) IS - 0278-6133 (Print) IS - 0278-6133 (Linking) VI - 45 IP - 11 DP - 2026 Nov TI - Clinically effective child change in family-based behavioral treatment for pediatric obesity: An individual participant mega-analysis. PG - 1059-1071 LID - 10.1037/hea0001612 [doi] AB - OBJECTIVE: Family-based behavioral treatment (FBT) is an evidence-based treatment that has shown statistically significant short- and long-term outcomes for children. However, statistical and clinical significance are different ways to study the impact of a treatment, and recent data have indicated the degree of body mass index z-score (zBMI) change that prevents the development of cardiometabolic disease. METHOD: We conducted a mega-analysis using an individual participant database extracted from 16 randomized controlled studies (N = 1,098) on FBT for 6-12-year-old children with overweight or obesity and a participating parent with overweight and obesity that had at least 1-year follow-up. These data were used to evaluate clinical effectiveness based on -0.25 zBMI change and what percentage of children showed reversal of obesity at 6-, 12-, 24-, 60-, and 120-month follow-up. Analyses also examined whether age and sex were predictors of zBMI change. RESULTS: Across the combined databases, 70%, 61%, 52%, 54%, and 68% met the -0.25 zBMI criteria, and 29%, 27%, 23%, 46%, and 48% reversed their obesity status at 6, 12, 24, 60, and 120 months, respectively. Age was a reliable predictor of change, with younger children showing greater change up to the 24-month follow-up. CONCLUSIONS: These results suggest FBT is associated with clinical effectiveness, with long-term effects stable or improving over time. These data support the utility of FBT, and providing data on the clinical effectiveness of pediatric obesity treatment complements traditional reporting of statistical significance of FBT to support the clinical utility of FBT. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Epstein, Leonard H AU - Epstein LH AUID- ORCID: 0000-0003-1167-8848 AD - Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo. FAU - Neuwald, Nicholas V AU - Neuwald NV AD - Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo. FAU - Paluch, Rocco A AU - Paluch RA AD - Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo. FAU - Moore, Molly D AU - Moore MD AD - Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo. FAU - Wilfley, Denise E AU - Wilfley DE AD - Department of Psychiatry, Washington University School of Medicine. LA - eng GR - R01 HD039792/HD/NICHD NIH HHS/United States GR - U01 HL131552/HL/NHLBI NIH HHS/United States GR - R01 HL075451/HL/NHLBI NIH HHS/United States GR - R01 HD036904/HD/NICHD NIH HHS/United States GR - R01 HD039778/HD/NICHD NIH HHS/United States GR - NH/NIH HHS/United States GR - U01 DK088380/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Meta-Analysis DEP - 20260611 PL - United States TA - Health Psychol JT - Health psychology : official journal of the Division of Health Psychology, American Psychological Association JID - 8211523 SB - IM MH - Child MH - Humans MH - *Behavior Therapy/methods MH - Body Mass Index MH - *Family Therapy/methods MH - *Pediatric Obesity/therapy MH - Randomized Controlled Trials as Topic MH - Treatment Outcome PMC - PMC13267373 MID - NIHMS2167753 COIS- The authors have no conflict of interest to report. EDAT- 2026/06/11 12:40 MHDA- 2026/10/02 03:09 PMCR- 2026/06/16 CRDT- 2026/06/11 11:34 PHST- 2026/10/02 03:09 [medline] PHST- 2026/06/11 12:40 [pubmed] PHST- 2026/06/11 11:34 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 2027-82787-001 [pii] AID - 10.1037/hea0001612 [doi] PST - ppublish SO - Health Psychol. 2026 Nov;45(11):1059-1071. doi: 10.1037/hea0001612. Epub 2026 Jun 11. PMID- 42275010 OWN - NLM STAT- Publisher LR - 20260611 IS - 2168-3824 (Electronic) IS - 0270-1367 (Linking) DP - 2026 Jun 11 TI - Examining Native Hawaiian and Pacific Islander Youth Attitudes Toward Physical Activity and Physical Education. PG - 1-8 LID - 10.1080/02701367.2026.2676647 [doi] AB - Native Hawaiian and Pacific Islander (NHPI) populations experience persistent disparities in physical activity (PA) and chronic disease, however, little is known about NHPI youths affective orientations toward PA and physical education (PE). The purpose of this study was to examine NHPI youths' attitudes toward PA and PE and their associations with intentions and behavior. Participants included 1,163 students in grades 4-12 from 11 schools (5 elementary, 6 secondary) across 2 islands in Hawai'i, with 57% identifying as NHPI. Students completed validated measures of PA attitudes, PE attitudes, PA intention, and self-reported PA. No differences emerged between NHPI and non-NHPI students across attitudes, intentions, or PA behavior. Within NHPI youth, positive PA attitudes were significantly associated with both PA intention and behavior, whereas PE attitudes were not. Findings challenge deficit-based assumptions that NHPI youth possess negative orientations toward PA. Instead, NHPI youth demonstrate positive PA attitudes that appear to operate independently of school-based PE experiences. This study contributes to the literature by highlighting the importance of distinguishing PA and PE attitudes within TPB-informed research and by underscoring the need for culturally responsive approaches that sustain positive PA dispositions across development. FAU - Hafoka, Crystal K AU - Hafoka CK AD - University of Hawai'i at Manoa. FAU - Centeio, Erin E AU - Centeio EE AUID- ORCID: 0000-0001-5465-4243 AD - University of Hawai'i at Manoa. FAU - Simonton, Kelly L AU - Simonton KL AUID- ORCID: 0000-0001-7261-2047 AD - University of Wyoming. FAU - Serna, A Ku'ulei AU - Serna AK AUID- ORCID: 0000-0001-9991-3544 AD - University of Hawai'i at Manoa. FAU - Mercier, Kevin J AU - Mercier KJ AUID- ORCID: 0000-0003-3505-2495 AD - Adelphi University. LA - eng PT - Journal Article DEP - 20260611 PL - United States TA - Res Q Exerc Sport JT - Research quarterly for exercise and sport JID - 8006373 SB - IM OTO - NOTNLM OT - Attitudes OT - Native Hawaiian and Pacific Islander Youth OT - culture OT - physical activity EDAT- 2026/06/11 12:38 MHDA- 2026/06/11 12:38 CRDT- 2026/06/11 11:33 PHST- 2026/06/11 12:38 [medline] PHST- 2026/06/11 12:38 [pubmed] PHST- 2026/06/11 11:33 [entrez] AID - 10.1080/02701367.2026.2676647 [doi] PST - aheadofprint SO - Res Q Exerc Sport. 2026 Jun 11:1-8. doi: 10.1080/02701367.2026.2676647. PMID- 42274851 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 7 DP - 2026 Jun 11 TI - Incidence and associated factors of metachronous contralateral cryptorchidism after unilateral cryptorchidism: a retrospective cohort study. LID - 486 [pii] LID - 10.1007/s00431-026-07154-4 [doi] AB - Acquired cryptorchidism is an increasingly recognized condition and may present bilaterally with a metachronous pattern. The objective of this study was to evaluate the incidence of acquired contralateral metachronous cryptorchidism and to identify associated factors in patients undergoing surgery for unilateral cryptorchidism. This retrospective cohort descriptive study included patients who underwent surgery for unilateral cryptorchidism in the Paediatric Surgery departments of Consorci Sanitari Alt Penedes-Garraf and Hospital Universitari Mutua Terrassa between 2005 and 2024. Demographic data, characteristics of cryptorchidism, and intraoperative findings from the initial surgery were recorded. A history of prematurity and obesity were also collected. A total of 275 patients were included. Contralateral acquired cryptorchidism developed in 11 of 111 patients with congenital cryptorchidism (9.9%; 95% CI 5.1%-17%) and in 29 of 164 patients with acquired cryptorchidism (17.7%; 95% CI 12.2%-24.4%). Multivariate analysis identified the following associated factors for metachronous contralateral cryptorchidism: acquired cryptorchidism at initial presentation (aOR = 4.00, 95% CI 1.60-9.99; p = 0.003), persistence of the processus vaginalis on the initially operated side (aOR = 5.94, 95% CI 2.44-14.48; p < 0.001) and prematurity (aOR = 6.38, 95% CI 1.75-23.25; p = 0.005). CONCLUSION: The overall incidence of metachronous cryptorchidism in patients with unilateral disease was 15%. A higher incidence was observed among patients with acquired cryptorchidism than among those with congenital cryptorchidism, although this difference did not reach statistical significance. These findings suggest that periodic follow-up until adolescence may be warranted in patients with unilateral cryptorchidism, particularly in those with acquired forms. Patients with congenital cryptorchidism require periodic follow-up until adolescence, while those with acquired unilateral cryptorchidism should be carefully monitored before surgery to detect bilateral involvement and allow simultaneous treatment. WHAT IS KNOWN: * Cryptorchidism affects 1-4% of full-term newborns, with long-term consequences for fertility and testicular cancer risk. Acquired cryptorchidism, the ascent of a previously descended testis, accounts for more than half of all cases. * The risk factors for metachronous contralateral cryptorchidism after unilateral disease remain poorly characterized, and no consensus exists on the appropriate follow-up strategy for these patients. WHAT IS NEW: * Metachronous contralateral cryptorchidism occurred in 15% of patients. The incidence was higher in patients with acquired cryptorchidism than in those with congenital cryptorchidism althouh the difference was not statistically significant. Persistence of the processus vaginalis at the time of surgery on the first side, and prematurity were other associated factors. * Prospective studies are needed to validate these associated factors and to determine whether active observation before surgery enables earlier detection of bilateral disease and synchronous orchidopexy. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Grande-Moreillo, C AU - Grande-Moreillo C AUID- ORCID: 0000-0002-8243-777X AD - Paediatric Surgery Unit Consorci Sanitari Alt Penedes I Garraf, Ronda de Sant Camil S/N. 08810, Sant Pere de Ribes, Spain. cgrande@csapg.cat. AD - Department of Paediatric Surgery Hospital, Universitari Mutua Terrassa, Placa Doctor Robert, 5. 08221, Terrassa, Spain. cgrande@csapg.cat. FAU - Perez-Lopez, C AU - Perez-Lopez C AUID- ORCID: 0000-0001-7400-4360 AD - Research Area, Consorci Sanitari Alt Penedes I Garraf, Ronda de Sant Camil S/N. 08810, Sant Pere de Ribes, Spain. FAU - Vicente-Sanchez, N AU - Vicente-Sanchez N AUID- ORCID: 0009-0001-7878-6918 AD - Department of Paediatric Surgery Hospital, Universitari Mutua Terrassa, Placa Doctor Robert, 5. 08221, Terrassa, Spain. FAU - Fuentes-Carretero, S AU - Fuentes-Carretero S AUID- ORCID: 0000-0002-0285-681X AD - Department of Paediatric Surgery Hospital, Universitari Mutua Terrassa, Placa Doctor Robert, 5. 08221, Terrassa, Spain. LA - eng PT - Journal Article DEP - 20260611 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Cryptorchidism/surgery/epidemiology MH - Male MH - Retrospective Studies MH - Incidence MH - Risk Factors MH - Infant MH - Child, Preschool MH - Infant, Newborn MH - Child OTO - NOTNLM OT - Acquired cryptorchidism OT - Cryptorchidism OT - Follow-up studies OT - Metachronous disease OT - Paediatrics OT - Undescended testis COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. The protocol was approved by the Research Ethics Committee of Hospital Universitari de Bellvitge (ref. PR030/24). Due to the retrospective nature of the study, informed consent was waived. Competing interests: The authors declare no competing interests. EDAT- 2026/06/11 12:41 MHDA- 2026/06/13 00:39 CRDT- 2026/06/11 11:17 PHST- 2026/02/09 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/05/20 00:00 [revised] PHST- 2026/06/13 00:39 [medline] PHST- 2026/06/11 12:41 [pubmed] PHST- 2026/06/11 11:17 [entrez] AID - 10.1007/s00431-026-07154-4 [pii] AID - 10.1007/s00431-026-07154-4 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jun 11;185(7):486. doi: 10.1007/s00431-026-07154-4. PMID- 42274442 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260804 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 8 DP - 2026 Aug TI - Creation and Psychometric Evaluation of the Teen Moms Child Feeding Readiness to Change Questionnaire for Teenage Mothers in Rural Suburbs of Nigeria. PG - 770-784 LID - S1499-4046(26)00125-9 [pii] LID - 10.1016/j.jneb.2026.05.001 [doi] AB - OBJECTIVE: To develop and validate the Teen Moms Child Feeding Readiness to Change Questionnaire for Sub-Saharan Africa for evaluating the transtheoretical stages of behavioral change related to infant and young child feeding. DESIGN: Cross-sectional study. SETTING: Communities with populations with low income in rural suburban areas of Abuja, Nigeria. PARTICIPANTS: Ten nutrition experts and 156 teenage mothers. METHODS: Nineteen items were generated on a 5-point Likert scale for responses. Two questions were eliminated after content evaluation by a panel of 10 nutrition experts and comprehensibility assessment by 6 teenage mothers. Unidimensionality and internal consistency reliability of the subscales were determined by factor loadings, Loevinger's scalability coefficient H and Molenaar Sijtsma rho coefficients. Construct validity was established via polytomous item response theory in 150 teenage mothers in rural suburbs of Abuja, Nigeria. RESULTS: The final questionnaire contained 11 questions in 3 subscales. All retained items had factor loadings > 0.4, Loevinger's coefficient H > 0.3, and rho coefficients > 0.6. All items displayed good discrimination (>/= 1) and difficulty parameters. Response characteristic curves indicated that the Likert option neither agree nor disagree was not frequently selected; thus, it was deleted. From scale information curves, it was observed that the contemplation, action, and maintenance subscales precisely estimated information for respondents with average ability to perform the latent construct. The precontemplation subscale contained more information for respondents with less than average abilities. CONCLUSIONS AND IMPLICATIONS: The Teen Moms Child Feeding Readiness to Change Questionnaire for Sub-Saharan Africa demonstrated promising preliminary evidence of validity and reliability for assessing Transtheoretical stages of change in teenage mothers. Further validation in larger and more diverse samples is warranted. CI - Copyright (c) 2026 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved. FAU - Sosanya, Mercy E AU - Sosanya ME AD - Department of Exercise and Nutrition Sciences, University at Buffalo, NY; Department of Nutrition and Dietetics, The Federal Polytechnic, Bauchi, Bauchi, Nigeria. Electronic address: mercysosanya@utexas.edu. FAU - Samuel, Temitope C AU - Samuel TC AD - Centre for Family Health Initiative, Abuja, Nigeria. FAU - Ugwu-Anyanwu, Krystal C AU - Ugwu-Anyanwu KC AD - Centre for Family Health Initiative, Abuja, Nigeria. FAU - Freeland-Graves, Jeanne H AU - Freeland-Graves JH AD - Department of Nutritional Sciences, University of Texas at Austin, Austin, TX. LA - eng PT - Journal Article PT - Validation Study DEP - 20260611 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Female MH - Nigeria MH - Adolescent MH - *Psychometrics MH - Surveys and Questionnaires/standards MH - Cross-Sectional Studies MH - Rural Population MH - Reproducibility of Results MH - *Adolescent Mothers/psychology/statistics & numerical data MH - Infant MH - *Feeding Behavior/psychology MH - Mothers OTO - NOTNLM OT - adolescent mothers OT - infant and young child feeding OT - psychometric validation OT - readiness to change OT - transtheoretical model EDAT- 2026/06/11 12:39 MHDA- 2026/08/09 15:17 CRDT- 2026/06/11 10:45 PHST- 2025/03/17 00:00 [received] PHST- 2026/04/09 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/08/09 15:17 [medline] PHST- 2026/06/11 12:39 [pubmed] PHST- 2026/06/11 10:45 [entrez] AID - S1499-4046(26)00125-9 [pii] AID - 10.1016/j.jneb.2026.05.001 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Aug;58(8):770-784. doi: 10.1016/j.jneb.2026.05.001. Epub 2026 Jun 11. PMID- 42274402 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1945-7243 (Electronic) IS - 0046-9580 (Print) IS - 0046-9580 (Linking) VI - 63 DP - 2026 Jan-Dec TI - Effectiveness of Fitbit-Based Interventions in Improving 24-hour Movement Behaviors: A Systematic Review and Meta-Analysis. PG - 469580261460723 LID - 10.1177/00469580261460723 [doi] LID - 00469580261460723 AB - IntroductionAll activities performed by an individual over a 24-hour period can be classified into four categories-moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), sedentary behavior (SB), and sleep-collectively referred to as 24-hour movement behaviors. Fitbit devices can not only monitor all components of 24-hour movement behaviors but are also cost-effective and reliable. The aim of this meta-analysis was to assess the impact of Fitbit-based interventions on 24-hour movement behaviors outcomes.MethodsTo identify studies that employed Fitbit devices as intervention tools to improve 24-hour movement behaviors, the following five electronic databases were searched: PubMed, Embase, SCOPUS, Cochrane Library, and Web of Science. Study quality was evaluated using the Cochrane Risk-of-Bias tool. Meta-analysis was performed using a random-effects model to assess the pooled effects of Fitbit-based interventions on MVPA, LPA, SB, and sleep.ResultsForty-five studies involving 5234 participants were included in this meta-analysis. Fitbit-based interventions can significantly increase MVPA (MD 4.44 min/day; 95% CI 2.77 to 6.10; P<0.05) and reduce SB (MD -10.36 min/day; 95% CI -18.40 to -2.32; P<0.05). However, these interventions fail to significantly increase LPA (MD -0.55 min/day; 95% CI -4.47 to 3.37; P=0.78) and sleep (MD 19.64 min/day; 95% CI -1.64 to 40.93; P=0.07). Interestingly, subgroup analyses showed that Fitbit-based interventions were more effective at improving MVPA, SB, and LPA in adults than in children and adolescents. Moreover, programs targeting multiple behavior changes simultaneously appeared to be more effective at reducing SB than those targeting changes in a single behavior.ConclusionsFitbit-based interventions can motivate a shift from SB and LPA to MVPA and sleep. Further, Fitbit devices may be a feasible and effective tool for improving 24-hour movement behaviors in adults. Nevertheless, additional studies are needed to explore the effectiveness of Fitbit-based interventions in improving 24-hour movement behaviors among children and adolescents. FAU - Wang, Wentao AU - Wang W AUID- ORCID: 0000-0003-0801-1196 AD - Department of Basic Education, Zhejiang Tongji Vocational College of Science and Technology, Hangzhou, China. RINGGOLD: 499569 AD - Department of Sports and Exercise Science, Zhejiang University, Hangzhou, China. RINGGOLD: 12377 FAU - Huang, Cong AU - Huang C AD - Department of Sports and Exercise Science, Zhejiang University, Hangzhou, China. RINGGOLD: 12377 FAU - Shen, Yi AU - Shen Y AD - Department of Basic Education, Zhejiang Tongji Vocational College of Science and Technology, Hangzhou, China. RINGGOLD: 499569 FAU - Cheng, Jing AU - Cheng J AD - Department of Basic Education, Zhejiang Tongji Vocational College of Science and Technology, Hangzhou, China. RINGGOLD: 499569 FAU - Wang, Ling AU - Wang L AD - Department of Sports and Arts, Zhejiang Gongshang University Hangzhou College of Commerce, Hangzhou, China. RINGGOLD: 499175 LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260611 PL - United States TA - Inquiry JT - Inquiry : a journal of medical care organization, provision and financing JID - 0171671 SB - IM MH - Humans MH - Sedentary Behavior MH - *Exercise/physiology MH - Sleep/physiology MH - *Fitness Trackers MH - Sleep Duration PMC - PMC13260979 OTO - NOTNLM OT - 24-hour movement behaviors OT - LPA OT - MVPA OT - SB OT - fitbit devices OT - meta-analysis OT - sleep COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/11 12:39 MHDA- 2026/06/13 07:33 PMCR- 2026/06/11 CRDT- 2026/06/11 10:23 PHST- 2026/06/13 07:33 [medline] PHST- 2026/06/11 12:39 [pubmed] PHST- 2026/06/11 10:23 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.1177_00469580261460723 [pii] AID - 10.1177/00469580261460723 [doi] PST - ppublish SO - Inquiry. 2026 Jan-Dec;63:469580261460723. doi: 10.1177/00469580261460723. Epub 2026 Jun 11. PMID- 42274160 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1784-973X (Electronic) IS - 0001-5385 (Linking) VI - 81 IP - 4 DP - 2026 Jun TI - Comparison of the oxygen uptake efficiency slope and 6-minute walk test in paediatric and adult Fontan patients. PG - 599-609 LID - 10.1080/00015385.2026.2681257 [doi] AB - BACKGROUND: Fontan patients experience progressive declines in exercise capacity, highlighting the importance of submaximal exercise parameters for clinical evaluation. OBJECTIVES: To evaluate the oxygen uptake efficiency slope (OUES/kg) compared to 6-minute walk test (6MWT) distance in paediatric and adult Fontan patients. METHODS: Participants included paediatric (<18 years) and adult (>/=18 years) Fontan patients and matched controls. All participants completed a treadmill CPET, and VO(2)peak, OUES, and related variables were recorded. 6MWT was also performed, with distance (m) recorded. RESULTS: Thirty-one Fontan patients and 30 age- and sex-matched controls were included (paediatric: 15 vs 14, both median 12 years; adults: 16 vs 16, median 20.5 vs 20 years). Both paediatric and adult Fontan patients had significantly lower OUES/kg compared to controls (p < 0.05). 6MWT distances were significantly lower in adult patients (p < 0.05) but not in paediatric patients (p > 0.05). OUES/kg and 6MWT distance were significantly correlated with VO(2)peak in both groups, showing stronger correlations in adults (r = 0.884, r = 0.789, p < 0.001) than in paediatric patients (r = 0.622, r = 0.609, p < 0.05). OUES/kg discriminated between patients and controls in both age groups (AUCs = 0.724 and 0.848), while 6MWT distance did so only for adults (AUC = 0.809). CONCLUSION: Both OUES/kg and 6MWT distance may serve as valuable indicators of submaximal exercise capacity in Fontan patients, particularly in adults when maximal CPET is not feasible. While OUES/kg demonstrated superior discriminatory ability, the 6MWT remains a simple and clinically useful tool, especially for evaluating functional capacity in adult Fontan patients. These findings emphasise the complementary value of both measures and highlight the importance of age-specific assessments in this population. FAU - Tekerlek, Haluk AU - Tekerlek H AUID- ORCID: 0000-0003-4514-4801 AD - School of Life and Health Sciences, Department of Physiotherapy, University of Roehampton, London, UK. FAU - Selcuk, Sinem Nur AU - Selcuk SN AD - Department of Paediatric Cardiology, Ankara Etlik City Hospital, Ankara, Turkiye. FAU - Basol-Goksuluk, Merve AU - Basol-Goksuluk M AD - Faculty of Medicine, Department of Biostatistics, Sakarya University, Sakarya, Turkiye. FAU - Aykan, Hayrettin Hakan AU - Aykan HH AD - Faculty of Medicine, Department of Paediatric Cardiology, Hacettepe University, Ankara, Turkiye. AD - Life Support Center, Hacettepe University, Ankara, Turkiye. FAU - Vardar-Yagli, Naciye AU - Vardar-Yagli N AD - Faculty of Physical Therapy and Rehabilitation, Department of Cardiorespiratory Rehabilitation, Hacettepe University, Ankara, Turkiye. FAU - Karagoz, Tevfik AU - Karagoz T AD - Faculty of Medicine, Department of Paediatric Cardiology, Hacettepe University, Ankara, Turkiye. FAU - Saglam, Melda AU - Saglam M AD - Faculty of Physical Therapy and Rehabilitation, Department of Cardiorespiratory Rehabilitation, Hacettepe University, Ankara, Turkiye. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260611 PL - England TA - Acta Cardiol JT - Acta cardiologica JID - 0370570 SB - IM MH - Humans MH - *Fontan Procedure/adverse effects MH - Female MH - Male MH - *Oxygen Consumption/physiology MH - *Walk Test/methods MH - *Exercise Tolerance/physiology MH - Adolescent MH - Child MH - Adult MH - *Heart Defects, Congenital/surgery/physiopathology MH - Young Adult MH - Age Factors MH - Time Factors OTO - NOTNLM OT - 6-minute walk test OT - Fontan OT - Oxygen uptake efficiency slope OT - cardiopulmonary exercise test OT - submaximal exercise capacity EDAT- 2026/06/11 12:40 MHDA- 2026/06/25 06:36 CRDT- 2026/06/11 08:23 PHST- 2026/06/25 06:36 [medline] PHST- 2026/06/11 12:40 [pubmed] PHST- 2026/06/11 08:23 [entrez] AID - 10.1080/00015385.2026.2681257 [doi] PST - ppublish SO - Acta Cardiol. 2026 Jun;81(4):599-609. doi: 10.1080/00015385.2026.2681257. Epub 2026 Jun 11. PMID- 42273634 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Primary caregivers' perceptions, needs, and expectations regarding nutritional management of children with chronic kidney disease: a qualitative study. PG - 1822018 LID - 10.3389/fpubh.2026.1822018 [doi] LID - 1822018 AB - BACKGROUND: Nutritional management plays a critical role in optimizing growth, delaying disease progression, and improving long-term outcomes in children with chronic kidney disease. However, caregivers' perceptions, experiences, and support needs regarding nutritional management remain insufficiently understood. METHODS: A qualitative descriptive study was conducted using semi-structured face-to-face interviews between May and July 2025 in a tertiary women's and children's hospital in Chengdu, China. Fifteen primary caregivers of children with CKD were recruited through purposive sampling. Data were analyzed using conventional content analysis with the assistance of NVivo 11.0 software. Data collection continued until thematic saturation was achieved. RESULTS: Four major themes and related subthemes emerged: (1) mismatch between caregivers' information needs and the current information environment; (2) variability in caregivers' willingness and ability to engage in nutritional learning; (3) barriers to translating intention into home-based nutritional management; and (4) caregivers' needs and expectations regarding nutritional management. Caregivers commonly reported limited access to reliable and authoritative nutritional information, difficulties in appraising information quality, and insufficient continuity of healthcare support. Learning engagement varied according to educational level, caregiving burden, and perceived practicality of information, while culturally influenced preferences (e.g., traditional Chinese medicine) also shaped participation in formal education. Despite generally strong motivation, caregivers frequently experienced an intention-behavior gap, struggling to translate knowledge into consistent dietary practices. CONCLUSION: Caregivers of children with CKD face substantial challenges in accessing, understanding, and applying nutritional information in daily care. These difficulties appear to be influenced by limitations in informational support, differences in motivation, and practical caregiving capacity. The findings highlight the importance of providing caregivers with clear, practical, and accessible nutritional support that better facilitates long-term home-based nutritional management for children with CKD. CI - Copyright (c) 2026 Luo, Guan, Liu and Zheng. FAU - Luo, Diyi AU - Luo D AD - Department of Pediatric Urinary Disease Center Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. AD - Sichuan Provincial Children's Hospital (Sichuan Provincial Children's Medical Center), Meishan, Sichuan, China. AD - West China Second University Hospital (Tianfu), Sichuan University, Meishan, Sichuan, China. FAU - Guan, Yujia AU - Guan Y AD - Department of Pediatric Urinary Disease Center Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. AD - Sichuan Provincial Children's Hospital (Sichuan Provincial Children's Medical Center), Meishan, Sichuan, China. AD - West China Second University Hospital (Tianfu), Sichuan University, Meishan, Sichuan, China. FAU - Liu, Lili AU - Liu L AD - Department of Pediatric Urinary Disease Center Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. AD - Sichuan Provincial Children's Hospital (Sichuan Provincial Children's Medical Center), Meishan, Sichuan, China. AD - West China Second University Hospital (Tianfu), Sichuan University, Meishan, Sichuan, China. FAU - Zheng, Yanni AU - Zheng Y AD - Department of Pediatric Urinary Disease Center Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. AD - Sichuan Provincial Children's Hospital (Sichuan Provincial Children's Medical Center), Meishan, Sichuan, China. AD - West China Second University Hospital (Tianfu), Sichuan University, Meishan, Sichuan, China. LA - eng PT - Journal Article DEP - 20260526 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Caregivers/psychology MH - Female MH - *Renal Insufficiency, Chronic/diet therapy MH - Qualitative Research MH - Child MH - China MH - Adult MH - Male MH - Interviews as Topic MH - Child, Preschool MH - *Health Knowledge, Attitudes, Practice MH - Middle Aged PMC - PMC13246598 OTO - NOTNLM OT - children OT - chronic kidney disease OT - nutritional management OT - primary caregivers OT - qualitative research COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/11 06:37 MHDA- 2026/06/13 00:39 PMCR- 2026/05/26 CRDT- 2026/06/11 04:55 PHST- 2026/03/03 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/06/13 00:39 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 04:55 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1822018 [doi] PST - epublish SO - Front Public Health. 2026 May 26;14:1822018. doi: 10.3389/fpubh.2026.1822018. eCollection 2026. PMID- 42273503 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260813 IS - 2250-0685 (Print) IS - 2321-3817 (Electronic) IS - 2250-0685 (Linking) VI - 16 IP - 6 DP - 2026 Jun TI - Creatine Supplementation in Pediatric Orthopedic Rehabilitation: A Translational Review and Proposed Clinical Trial Framework. PG - 293-299 LID - 10.13107/jocr.2026.v16.i06.7450 [doi] AB - INTRODUCTION: Knee arthroscopy is a commonly performed minimally invasive orthopedic procedure in pediatric and adolescent populations, particularly for sports-related injuries such as ligament tears and meniscal pathology. Optimization of post-operative recovery is essential in this age group to preserve muscle mass, restore neuromuscular control, and facilitate safe return to activity during a critical period of musculoskeletal development. Perioperative nutritional strategies represent a modifiable adjunct to rehabilitation; however, their role in pediatric orthopedic recovery remains insufficiently defined. MATERIALS AND METHODS: This comprehensive narrative review synthesizes mechanistic, translational, and clinical literature on creatine supplementation to evaluate its potential role in enhancing post-operative recovery following pediatric and adolescent knee arthroscopy. Relevant literature was identified through structured searches of PubMed, Scopus, and Google Scholar, emphasizing adult orthopedic rehabilitation trials, experimental studies of skeletal muscle metabolism, perioperative nutrition research, and limited pediatric supplementation data. Although not conducted as a formal systematic review, a structured and targeted search strategy was used to enhance methodological rigor and reproducibility. RESULTS: Across adult surgical and immobilization models, creatine supplementation has demonstrated preservation of muscle mass, enhanced strength recovery, improved GLUT4-mediated glucose uptake, augmented glycogen storage, reduced inflammatory signaling, and attenuation of disuse-related muscle atrophy. Although direct pediatric surgical data are lacking, consistent mechanistic and clinical findings, combined with creatine's endogenous production and favorable safety profile in youth athletic populations, provide a biologically plausible rationale for investigation in pediatric orthopedic settings. CONCLUSION: The convergence of adult evidence and the absence of pediatric-specific clinical trials highlights a critical gap in the literature. Creatine supplementation represents a promising adjunct to post-operative rehabilitation following pediatric knee arthroscopy, warranting prospective clinical trials to determine its efficacy, safety, and optimal perioperative use. CI - Copyright: (c) Indian Orthopaedic Research Group. FAU - Hoffman, Isaiah D AU - Hoffman ID AD - College of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California. FAU - Combs, Kristen AU - Combs K AD - Department of Orthopedic Surgery, Shriners Hospitals for Children, Pasadena, California. LA - eng PT - Journal Article PT - Review PL - India TA - J Orthop Case Rep JT - Journal of orthopaedic case reports JID - 101641392 PMC - PMC13248198 OTO - NOTNLM OT - Creatine supplementation OT - knee arthroscopy OT - muscle recovery OT - pediatric orthopedics OT - rehabilitation OT - sports medicine COIS- Conflict of Interest: Nil EDAT- 2026/06/11 06:37 MHDA- 2026/06/11 06:38 PMCR- 2026/06/01 CRDT- 2026/06/11 04:54 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/03 00:00 [revised] PHST- 2026/06/11 06:38 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 04:54 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - JOCR-16-6-293 [pii] AID - 10.13107/jocr.2026.v16.i06.7450 [doi] PST - ppublish SO - J Orthop Case Rep. 2026 Jun;16(6):293-299. doi: 10.13107/jocr.2026.v16.i06.7450. PMID- 42273365 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260922 IS - 1662-4548 (Print) IS - 1662-453X (Electronic) IS - 1662-453X (Linking) VI - 20 DP - 2026 TI - Physiological determinants of cortical P100 responses in pattern visual evoked potentials: a scoping review. PG - 1821657 LID - 10.3389/fnins.2026.1821657 [doi] LID - 1821657 AB - BACKGROUND: Pattern visual evoked potentials (pattern VEP) are widely used for functional assessment of the visual pathways. The P100 component represents the principal clinical parameter owing to its relative interindividual stability and diagnostic value. However, both latency and amplitude are modulated by multiple physiological and environmental factors, which complicates interpretation and the establishment of reliable reference standards. This scoping review aimed to systematically map determinants of P100 parameters in healthy individuals. MAIN TEXT: The review was conducted in accordance with PRISMA-ScR and Joanna Briggs Institute methodology. Databases were searched for studies published between 2015 and 2025 that examined biological, refractive, anthropometric, metabolic, or environmental influences on pattern VEP parameters in healthy populations. Owing to methodological heterogeneity, findings were synthesized descriptively. Thirty-nine studies met the inclusion criteria. Age emerged as the most consistent determinant of P100 parameters. Latency followed a non-linear trajectory across the lifespan, with shortening during maturation, stabilization in early adulthood, and progressive prolongation after approximately 40 years of age, whereas amplitude generally declined with aging. Sex differences predominantly affected amplitude, with women typically demonstrating higher P100 or N75-P100 amplitudes in adult populations; latency differences were less consistent and often minimal in paediatric cohorts. Retinal image quality exerted a strong dose-dependent effect on P100 parameters: increasing refractive blur and higher-order aberrations were associated with progressive latency prolongation and amplitude reduction, particularly for small check sizes. Ocular dominance showed no clinically meaningful interocular asymmetry. Metabolic disturbances were associated with prolonged latency in selected populations, whereas anthropometric variables such as head size and height demonstrated weak or inconsistent associations. Among environmental factors, acute alcohol intake prolonged P100 latency, while moderate caffeine consumption had no significant effect. CONCLUSION: Age and retinal image quality represent the primary physiological determinants of P100 latency and amplitude in healthy individuals. Most other modifiers exert modest or context-dependent effects. Consideration of these variables is essential for accurate interpretation of pattern VEP recordings and for establishing reliable local reference standards consistent with ISCEV recommendations. CI - Copyright (c) 2026 Lisowski, Lisowska, Labieniec, Zarzecki, Zalewski, Obuchowska and Konopinska. FAU - Lisowski, Lukasz AU - Lisowski L AD - Department of Ophthalmology, Medical University of Bialystok, Bialystok, Poland. FAU - Lisowska, Jolanta AU - Lisowska J AD - Individual Medical Practice, Bialystok, Poland. FAU - Labieniec, Lukasz AU - Labieniec L AD - Faculty of Physics, University of Bialystok, Bialystok, Poland. FAU - Zarzecki, Mateusz AU - Zarzecki M AD - Department of Ophthalmology, Medical University of Bialystok, Bialystok, Poland. FAU - Zalewski, Dominik AU - Zalewski D AD - Lens Center for Eye Diagnostics and Microsurgery, Olsztyn, Poland. FAU - Obuchowska, Iwona AU - Obuchowska I AD - Department of Ophthalmology, Medical University of Bialystok, Bialystok, Poland. FAU - Konopinska, Joanna AU - Konopinska J AD - Department of Ophthalmology, Medical University of Bialystok, Bialystok, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260526 PL - Switzerland TA - Front Neurosci JT - Frontiers in neuroscience JID - 101478481 EIN - Front Neurosci. 2026 Jun 18;20:1892090. doi: 10.3389/fnins.2026.1892090. PMID: 42395319 PMC - PMC13246599 OTO - NOTNLM OT - ISCEV standards OT - P100 amplitude OT - P100 latency OT - aging brain OT - cortical processing OT - pattern visual evoked potential OT - retinal image quality OT - visual electrophysiology COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/11 06:37 MHDA- 2026/06/11 06:38 PMCR- 2026/05/26 CRDT- 2026/06/11 04:53 PHST- 2026/03/02 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/06/11 06:38 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 04:53 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - 10.3389/fnins.2026.1821657 [doi] PST - epublish SO - Front Neurosci. 2026 May 26;20:1821657. doi: 10.3389/fnins.2026.1821657. eCollection 2026. PMID- 42273093 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260813 IS - 2223-4292 (Print) IS - 2223-4306 (Electronic) IS - 2223-4306 (Linking) VI - 16 IP - 6 DP - 2026 Jun 1 TI - Comparative study of Gd-EOB-DTPA-enhanced magnetic resonance imaging signal intensity parameters and albumin-bilirubin grade for liver function assessment based on early and middle-stage of liver dysfunction. PG - 456 LID - 10.21037/qims-2025-aw-2463 [doi] LID - 456 AB - BACKGROUND: Gadolinium-ethoxy benzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) enables not only liver lesion detection but also a one-stop assessment of hepatic function. Among the commonly used liver function scoring systems, the albumin-bilirubin (ALBI) grade is more objective than the Child-Turcotte-Pugh (CTP) grade and is particularly suitable for evaluating liver function in patients with early and middle-stage chronic liver disease. However, although various Gd-EOB-DTPA-enhanced MRI signal intensity (SI) parameters have been employed for liver function assessment, a comprehensive comparison of their efficacy is lacking, and no consensus exists on the optimal parameter. This study aimed to compare the efficacy of eight Gd-EOB-DTPA-enhanced MRI SI parameters in assessing liver function based on the ALBI grading system and identify the optimal imaging biomarker for clinical application. METHODS: A total of 99 high-risk patients with hepatitis B-related hepatocellular carcinoma (HCC) in the early or middle stages (61 with ALBI grade 1 and 38 with ALBI grades 2-3) underwent Gd-EOB-DTPA-enhanced MRI. Eight parameters were analyzed, including the relative enhancement rate of hepatic parenchyma, liver-muscle contrast ratio, liver-spleen contrast ratio, liver-portal vein contrast ratio, liver-muscle ratio growth rate, liver-spleen ratio growth rate, relative SI of biliary tract, and portal vein-spleen contrast ratio. Statistical analyses included receiver operating characteristic (ROC) curves evaluation, Spearman correlation, and independent-samples t-test to compare diagnostic performance and correlate parameters with ALBI scores. RESULTS: Liver-portal vein contrast ratio showed the numerically highest discriminative power for distinguishing ALBI grade 1 from grades 2-3 in all MRI parameters [area under the curve (AUC): 0.806, 95% confidence interval (CI): 0.715-0.897; sensitivity: 85.2%, specificity: 63.2%, cutoff value: 1.4763], followed by liver-spleen contrast ratio (AUC: 0.799, cutoff value: 1.7536) and relative enhancement rate of hepatic parenchyma (AUC: 0.765, cutoff value: 0.7874). Liver-muscle ratio growth rate exhibited moderate efficacy (AUC: 0.730, cutoff value: 0.9116). Parameters showed significant correlations with ALBI scores (|r|: 0.368-0.532, P<0.001), except for portal vein-spleen contrast ratio (r=0.116, P=0.253). The AUC of relative SI of biliary tract was 0.678. The cutoff value of relative SI of biliary tract was 4.3656. The assessment of portal vein-spleen contrast ratio did not show a significant association with functional differences (P=0.589). CONCLUSIONS: Liver-portal vein contrast ratio showed the numerically best performance among all MRI parameters for differentiating ALBI grades in this study population, offering superior sensitivity for early-stage liver dysfunction assessment. Gd-EOB-DTPA-enhanced MRI not only enables a more accurate prediction of postoperative functional liver reserve but also provides a comprehensive foundation for clinicians to formulate optimal, individualized treatment strategies, thereby potentially reducing the incidence of postoperative complications. Meanwhile, we caution against reliance on portal vein-spleen contrast ratio or biliary signal measurements. CI - (c) AME Publishing Company. FAU - Xia, Ruike AU - Xia R AD - Department of Nuclear Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Wu, Xiaoxiao AU - Wu X AUID- ORCID: 0009-0007-2523-4849 AD - Medical Imaging College, Shanghai University of Medicine and Health Sciences, Shanghai, China. AD - School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China. FAU - Zheng, Jun AU - Zheng J AD - Department of Radiology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Wang, Xiaoyang AU - Wang X AD - Department of Nuclear Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Peng, Wenxian AU - Peng W AUID- ORCID: 0000-0001-9889-3537 AD - Medical Imaging College, Shanghai University of Medicine and Health Sciences, Shanghai, China. LA - eng PT - Journal Article DEP - 20260508 PL - China TA - Quant Imaging Med Surg JT - Quantitative imaging in medicine and surgery JID - 101577942 PMC - PMC13247879 OTO - NOTNLM OT - Gadolinium-ethoxy benzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) OT - albumin-bilirubin grade (ALBI grade) OT - contrast-enhanced scan OT - liver function OT - magnetic resonance imaging (MRI) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-2025-aw-2463/coif). The authors have no conflicts of interest to declare. EDAT- 2026/06/11 06:39 MHDA- 2026/06/11 06:40 PMCR- 2026/06/01 CRDT- 2026/06/11 04:50 PHST- 2025/11/18 00:00 [received] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/06/11 06:40 [medline] PHST- 2026/06/11 06:39 [pubmed] PHST- 2026/06/11 04:50 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - qims-16-06-456 [pii] AID - 10.21037/qims-2025-aw-2463 [doi] PST - ppublish SO - Quant Imaging Med Surg. 2026 Jun 1;16(6):456. doi: 10.21037/qims-2025-aw-2463. Epub 2026 May 8. PMID- 42272737 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Longitudinal analysis of behavioral addictions among children and adolescents in the context of the COVID-19 pandemic. PG - 1791527 LID - 10.3389/fpsyg.2026.1791527 [doi] LID - 1791527 AB - INTRODUCTION: Behavioral addictions in childhood and adolescence remain understudied, particularly beyond digital media use. The COVID-19 pandemic introduced substantial disruptions to youths' daily routines, social functioning, and emotional well-being, potentially increasing vulnerability to maladaptive behavioral patterns. This three-wave longitudinal study examined trajectories and correlates of gambling, shopping, exercise, and eating addiction symptoms among children and adolescents across the pandemic period. METHODS: The study included 1,665 Israeli students aged 9-16.7 years assessed before the COVID-19 pandemic (October 2019), after the first wave (November 2020), and after the fifth wave and return to regular schooling (April 2022). Participants completed validated measures of behavioral addiction symptoms, psychiatric symptoms, negative and positive affect, sensation seeking, life satisfaction, social support, secure attachment, hope, future orientation, grit, and gratitude. Structural equation modeling tested indirect effects of protective factors on behavioral addictions via risk factors at baseline, and linear growth-curve models estimated change in addiction symptoms over time. RESULTS: Symptoms of exercise, gambling, and shopping addictions increased significantly across the three time points, whereas eating addiction symptoms remained stable. Negative affect, psychiatric symptoms, and sensation seeking predicted higher levels of behavioral addiction, and social support was unexpectedly associated with higher exercise, gambling, and eating addiction symptoms. In contrast, future orientation, life satisfaction, hope, positive emotions, and secure attachment were linked to fewer symptoms. Protective factors were related to lower behavioral addiction symptoms only indirectly, through their associations with reduced negative affect and psychiatric symptoms, indicating full mediation. Girls reported more shopping and eating addiction symptoms, whereas boys reported more gambling and exercise symptoms; older age was linked to fewer shopping, exercise, and eating symptoms but more gambling symptoms. DISCUSSION: These findings suggest that youth behavioral addictions intensified during and after the pandemic, even when most symptoms remained subclinical. Emotional and social resources functioned as resilience factors primarily by shaping mental health, highlighting negative affect and psychiatric distress as key intervention targets to prevent behavioral addictions in children and adolescents. CI - Copyright (c) 2026 Farbstein-Yavin, Shoshani, Gvion and Kor. FAU - Farbstein-Yavin, Shaked AU - Farbstein-Yavin S AD - Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel. FAU - Shoshani, Anat AU - Shoshani A AD - Baruch Ivcher School of Psychology, Reichman University, Herzliya, Israel. FAU - Gvion, Yari AU - Gvion Y AD - Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel. FAU - Kor, Ariel AU - Kor A AD - Baruch Ivcher School of Psychology, Reichman University, Herzliya, Israel. LA - eng PT - Journal Article DEP - 20260526 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13246624 OTO - NOTNLM OT - COVID-19 pandemic OT - behavioral addictions OT - children and adolescents OT - developmental pathways OT - longitudinal study OT - risk and protective factors OT - youth mental health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/11 06:35 MHDA- 2026/06/11 06:36 PMCR- 2026/05/26 CRDT- 2026/06/11 04:46 PHST- 2026/01/19 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/06/11 06:36 [medline] PHST- 2026/06/11 06:35 [pubmed] PHST- 2026/06/11 04:46 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1791527 [doi] PST - epublish SO - Front Psychol. 2026 May 26;17:1791527. doi: 10.3389/fpsyg.2026.1791527. eCollection 2026. PMID- 42272593 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - Comparative Diagnostic Accuracy of Spheno-Occipital Synchondrosis and Cervical Vertebral Maturation Index in Predicting Mandibular Growth Parameters in Adolescents: A Systematic Review and Meta-Analysis. PG - e108572 LID - 10.7759/cureus.108572 [doi] LID - e108572 AB - This systematic review and meta-analysis evaluated and compared the diagnostic utility of spheno-occipital synchondrosis maturation and the cervical vertebral maturation index for identifying mandibular growth parameters in adolescents. Longitudinal and mixed-longitudinal human studies that assessed spheno-occipital synchondrosis maturation and/or the cervical vertebral maturation index as index tests against mandibular growth parameters as the reference standard were considered eligible. Cross-sectional studies without a longitudinal growth reference and studies lacking extractable diagnostic accuracy data were excluded. A comprehensive search of PubMed/MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Library was performed from database inception to the final search date, and grey literature was additionally screened through ProQuest Dissertations & Theses, selected university repositories, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform. Risk of bias and applicability concerns were independently assessed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Sensitivity estimates were derived from 2 x 2 contingency tables and pooled using a random-effects model, while the association between spheno-occipital synchondrosis maturation and cervical vertebral maturation index stages was synthesized through correlation meta-analysis. Six studies involving adolescents approximately 10 to 19 years of age met the inclusion criteria. Three longitudinal studies were included in the diagnostic accuracy meta-analysis for the cervical vertebral maturation index, and three cross-sectional studies contributed four datasets to the correlation meta-analysis examining the relationship between spheno-occipital synchondrosis maturation and the cervical vertebral maturation index. The cervical vertebral maturation index demonstrated moderate diagnostic performance for identifying mandibular growth phases, although sensitivity estimates varied notably across studies. Spheno-occipital synchondrosis maturation showed a strong pooled association with mandibular growth and skeletal maturation, with a random-effects correlation of approximately 0.8, although heterogeneity was considerable. Overall, both measures appear clinically informative for estimating mandibular growth timing in adolescents, with spheno-occipital synchondrosis maturation showing a strong relationship with skeletal maturation and the cervical vertebral maturation index demonstrating moderate diagnostic value for identifying phases of mandibular growth. No external funding was received. This review was registered in PROSPERO (CRD420251175309). CI - Copyright (c) 2026, Awachat et al. FAU - Awachat, Akshata AU - Awachat A AD - Orthodontics and Dentofacial Orthopaedics, Ranjeet Deshmukh Dental College and Research Centre, Nagpur, Nagpur, IND. FAU - Hazare, Ananya AU - Hazare A AD - Orthodontics and Dentofacial Orthopaedics, Ranjeet Deshmukh Dental College and Research Centre, Nagpur, Nagpur, IND. LA - eng PT - Journal Article PT - Review DEP - 20260509 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13247218 OTO - NOTNLM OT - cervical vertebral maturation index OT - cone-beam computed tomography OT - mandibular growth OT - skeletal maturity OT - spheno-occipital synchondrosis OT - systematic review and meta-analysis COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/06/11 06:37 MHDA- 2026/06/11 06:38 PMCR- 2026/05/09 CRDT- 2026/06/11 04:44 PHST- 2026/05/09 00:00 [accepted] PHST- 2026/06/11 06:38 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 04:44 [entrez] PHST- 2026/05/09 00:00 [pmc-release] AID - 10.7759/cureus.108572 [doi] PST - epublish SO - Cureus. 2026 May 9;18(5):e108572. doi: 10.7759/cureus.108572. eCollection 2026 May. PMID- 42272568 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260922 IS - 2472-1972 (Electronic) IS - 2472-1972 (Linking) VI - 10 IP - 7 DP - 2026 Jul TI - Feasibility, reproducibility, and cold-induced energy expenditure using whole-room calorimetry in adults and children. PG - bvag102 LID - 10.1210/jendso/bvag102 [doi] LID - bvag102 AB - CONTEXT: To understand energy balance, whole-room indirect calorimetry (WRIC) allows for accurate measurement of energy expenditure (EE). OBJECTIVE: To examine the relationship between cold-induced resting EE and brown adipose tissue (BAT) activity measured by magnetic resonance imaging (MRI) and to evaluate WRIC system (WRICS) performance and feasibility of use in children and adults. METHODS: The WRICS was equipped with a Promethion High-Definition Room Calorimetry System. Technical validation utilized nitrogen (N(2)) and carbon dioxide (CO(2)) gas infusions. Healthy adults (n = 21) and children aged 8-17 years (n = 17) attended two 4-hour WRIC visits (one week apart) and one MRI visit. Resting EE at 25 degrees C (REE(25)) was compared between visits and to REE at 18 degrees C (REE(18)). Recruitment and completion rates were examined. BAT activity was assessed by MRI as the decline in supraclavicular proton density fat fraction during 18 degrees C cold exposure. RESULTS: Gas infusion testing confirmed high accuracy (respiratory exchange ratio [RER] = 0.99; 95% CI 0.991-0.996). Study completion rates were high (adults: 20/21; children: 17/18). REE(25) over a 10-minute period was consistent between visits (adults: 1.68 +/- 0.462 vs 1.66 +/- 0.301 kcal/min, P = 0.77; children: 1.50 +/- 0.358 vs 1.58 +/- 0.348 kcal/min, P = .25). Cold exposure increased fasting EE by 0.21 kcal/min (adults) and 0.14 kcal/min (children). BAT activity was correlated with REE(18) in adults (r = 0.49, P = .04). CONCLUSION: WRICS use was feasible in adults and children. Changes in EE during cold (ie, cold-induced thermogenesis) were measurable and related to BAT activity, supporting the usefulness of this system in the assessment of EE in response to interventions in adults and children. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Cheveldayoff, Paige AU - Cheveldayoff P AUID- ORCID: 0000-0003-4907-3019 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Alamri, Bader AU - Alamri B AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Wang, Dongdong AU - Wang D AUID- ORCID: 0000-0002-6195-4428 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Gonzalez, Rogelio Cruz AU - Gonzalez RC AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Thomas, Aaron C Q AU - Thomas ACQ AUID- ORCID: 0009-0003-4985-586X AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Konyer, Norm AU - Konyer N AD - Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada L8P 3B7. FAU - Noseworthy, Michael D AU - Noseworthy MD AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada L8P 3B7. AD - Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Gerstein, Hertzel C AU - Gerstein HC AUID- ORCID: 0000-0001-8072-2836 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Punthakee, Zubin AU - Punthakee Z AUID- ORCID: 0000-0003-4894-3617 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Steinberg, Gregory R AU - Steinberg GR AUID- ORCID: 0000-0001-5425-8275 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Morrison, Katherine M AU - Morrison KM AUID- ORCID: 0000-0002-1737-256X AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5. LA - eng PT - Journal Article DEP - 20260505 PL - United States TA - J Endocr Soc JT - Journal of the Endocrine Society JID - 101697997 PMC - PMC13248870 OTO - NOTNLM OT - BAT activity OT - cold exposure OT - energy expenditure OT - indirect calorimetry OT - obesity OT - pediatrics EDAT- 2026/06/11 06:37 MHDA- 2026/06/11 06:38 PMCR- 2026/05/05 CRDT- 2026/06/11 04:44 PHST- 2025/09/16 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/06/11 06:38 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 04:44 [entrez] PHST- 2026/05/05 00:00 [pmc-release] AID - bvag102 [pii] AID - 10.1210/jendso/bvag102 [doi] PST - epublish SO - J Endocr Soc. 2026 May 5;10(7):bvag102. doi: 10.1210/jendso/bvag102. eCollection 2026 Jul. PMID- 42271514 OWN - NLM STAT- MEDLINE DCOM- 20260816 LR - 20260825 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 Jun 11 TI - Efficacy and safety of SarogLItazar as an add-on medication to Metformin and lifestyle intervention in women with PolyCystic Ovary Syndrome (SLIM-PCOS trial): study protocol for a randomized, open-label, parallel group clinical trial. LID - 10.1186/s13063-026-09534-5 [doi] LID - 532 AB - BACKGROUND: Emerging concepts on the role of insulin resistance (IR) in the pathogenesis of polycystic ovary syndrome (PCOS) have driven a shift in the therapeutic approach towards interventions targeting IR. SarogLItazar as an add-on to Metformin in PolyCystic Ovary Syndrome (SLIM-PCOS) trial aims to test the efficacy and safety of saroglitazar, a dual peroxisome proliferator-activated receptor (PPAR alpha/gamma) agonist belonging to "glitazar" class of drugs, on top of metformin and lifestyle intervention in PCOS. METHODS: SLIM-PCOS is an investigator-initiated, randomized, open label, parallel group, superiority, clinical trial. Around 140 PCOS patients will be randomized in 1:1 ratio to either of the two study groups: Group A: tablet saroglitazar (4 mg daily) + tablet metformin (500 mg twice daily) + lifestyle intervention; and Group B: tablet metformin + lifestyle intervention. Lifestyle intervention will comprise of dietary intervention and physical activity. Treatment will be given for 24 weeks and post-treatment follow up done at 36 weeks. The primary outcome is to compare the change in serum sex hormone binding globulin (SHBG) levels at 24 weeks from baseline between the two groups. Secondary efficacy outcomes include clinical (anthropometry, hirsutism, menstrual cycles); metabolic and gonadal parameters (lipid profile, IR, ovarian hormones and androgens, metabolic syndrome); hepatic steatosis on transabdominal scan and quality of life. Safety outcomes include patient reported adverse events, hematological and biochemical safety parameters. Data will be analysed as per intention to treat (ITT) principle using validated statistical software. Two-tailed P-value < 0.05 will be considered statistically significant. DISCUSSION: SLIM-PCOS trial will provide evidence on the potential therapeutic application of saroglitazar in PCOS. Based on the study outcomes and the drug's mechanism of action, future studies may be planned to investigate into the role of this novel glitazar in PCOS patients having diabetes, dyslipidemia, non-alcoholic fatty liver disease and other associated co-morbidities. TRIAL REGISTRATION: Prospectively registered with the Clinical Trials Registry of India (Trial ID: CTRI/2025/09/094653); registered September 12, 2025. https://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=142027&EncHid=25944.27666&modid=1&compid=19 . CI - (c) 2026. The Author(s). FAU - Mittal, Niti AU - Mittal N AD - Department of Pharmacology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences (PGIMS), Rohtak, Haryana, 124001, India. drnitimittal@uhsr.ac.in. FAU - Singhal, Savita AU - Singhal S AD - Department of Obstetrics & Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences (PGIMS), Rohtak, Haryana, 124001, India. FAU - Mittal, Rakesh AU - Mittal R AD - Department of Pharmacology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences (PGIMS), Rohtak, Haryana, 124001, India. LA - eng GR - HSCSIT/R&D/2025/1558/Haryana State Council for Science, Innovation and Technology, Government of Haryana/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260611 PL - England TA - Trials JT - Trials JID - 101263253 RN - 9100L32L2N (Metformin) RN - 0 (Phenylpropionates) RN - E0YMX3S4JD (saroglitazar) RN - 0 (Hypoglycemic Agents) RN - 0 (PPAR-gamma Agonists) RN - 0 (PPAR alpha) RN - 0 (PPAR gamma) RN - 0 (Pyrroles) SB - IM MH - Humans MH - Female MH - *Metformin/adverse effects/therapeutic use/administration & dosage MH - *Polycystic Ovary Syndrome/therapy/diagnosis/blood/drug therapy/physiopathology MH - *Phenylpropionates/adverse effects/therapeutic use/administration & dosage MH - *Hypoglycemic Agents/adverse effects/therapeutic use MH - Treatment Outcome MH - Randomized Controlled Trials as Topic MH - Drug Therapy, Combination MH - Insulin Resistance MH - Adult MH - Time Factors MH - Young Adult MH - PPAR-gamma Agonists MH - Adolescent MH - PPAR alpha/agonists MH - *Risk Reduction Behavior MH - PPAR gamma/agonists MH - Life Style MH - Pyrroles PMC - PMC13480098 OTO - NOTNLM OT - Lifestyle intervention OT - Metformin OT - Polycystic ovary syndrome OT - Randomised trial OT - Saroglitazar OT - Study protocol COIS- Declarations. Ethics approval and consent to participate: This study is approved by the by Biomedical Research Ethics Committee of our institute vide letter no. BREC/25/278 dated 09.09.2025 in accordance with the ethical standards defined under Declaration of Helsinki and New Drugs and Clinical Trials Rules, 2019. Written informed consent will be obtained from all the participants before their inclusion in the study. The participants will be provided with detailed information regarding the purpose, procedures, potential risks, and benefits of the study, and their voluntary participation and right to withdraw at any time will be emphasized. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/11 06:39 MHDA- 2026/08/17 05:38 PMCR- 2026/06/11 CRDT- 2026/06/11 00:17 PHST- 2025/11/16 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/08/17 05:38 [medline] PHST- 2026/06/11 06:39 [pubmed] PHST- 2026/06/11 00:17 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.1186/s13063-026-09534-5 [pii] AID - 9534 [pii] AID - 10.1186/s13063-026-09534-5 [doi] PST - epublish SO - Trials. 2026 Jun 11;27(1):532. doi: 10.1186/s13063-026-09534-5. PMID- 42271444 OWN - NLM STAT- MEDLINE DCOM- 20260816 LR - 20260819 IS - 1477-7525 (Electronic) IS - 1477-7525 (Linking) VI - 24 IP - 1 DP - 2026 Jun 10 TI - Predicting poor health-related quality of life among Chinese adolescents using explainable machine learning: the role of school adjustment, family context, and lifestyle factors. LID - 10.1186/s12955-026-02568-y [doi] LID - 105 AB - BACKGROUND: Adolescents' health-related quality of life (HRQoL) is influenced by multiple domains, including school, family, and individual lifestyle. However, evidence remains limited on accurately predicting adolescent HRQoL and identifying modifiable determinants. This study aimed to develop a machine-learning prediction model for adolescent HRQoL and to determine key contextual factors associated with low quality of life. METHODS: This cross-sectional study included 20,236 adolescents (51.71% female; mean age 15.97 years). HRQoL was assessed using the validated Quality of Life Scale for Children and Adolescents (QLSCA). Twenty predictors covering school adjustment, family characteristics, and health behaviours were entered into 9 machine-learning classifiers and logistic regression. Feature contributions were examined using permutation importance, partial dependence plots (PDPs), and SHapley Additive exPlanations (SHAP). Stratified analyses by sex and school stage were conducted to identify group-specific determinants. RESULTS: School adjustment was the primary predictor of HRQoL, with self-management and peer relations contributing most. Family factors ranked next, particularly more frequent exercise with parents, which was associated with higher HRQoL. Among lifestyle behaviours, higher physical activity and healthier dietary patterns were associated with better HRQoL, whereas excessive screen time was associated with poorer HRQoL. In stratified analyses, peer relations and physical activity were more influential among boys, while self-management, exercising with parents, and adequate sleep contributed more among girls. Middle school students showed more adverse associations with disruptive/antisocial behaviours and screen time, whereas high school students derived greater benefits from family interaction and health behaviours. CONCLUSIONS: Explainable machine-learning analyses highlight school adjustment as a central correlate of adolescent HRQoL, alongside family characteristics and health behaviours. These findings provide multidimensional evidence to support targeted interventions in educational, family, and public health settings to improve adolescents' HRQoL. CI - (c) 2026. The Author(s). FAU - Zhao, Liangyu AU - Zhao L AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Gao, Yan AU - Gao Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. gaoyanluck@sdu.edu.cn. FAU - Liu, Chenchen AU - Liu C AD - School of Medical Information Engineering, Jining Medical University, Jining, 272067, China. FAU - Zhang, Zeqi AU - Zhang Z AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Yang, Yuke AU - Yang Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Hu, Yining AU - Hu Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Sui, Wenze AU - Sui W AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Ma, Sen AU - Ma S AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Zhang, Shuoqin AU - Zhang S AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Lai, Xinxin AU - Lai X AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Wang, Zhiying AU - Wang Z AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Yang, Zhiwen AU - Yang Z AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Yi, Xiangren AU - Yi X AD - School of Physical Education, Shandong University, Jinan, 250061, China. LA - eng GR - 21BTY054/National Social Science Fund of China/ GR - 2024YFC3607603/National Key Research and Development Program of China/ GR - 202409A07/National Population Health Data Center/ PT - Journal Article DEP - 20260610 PL - England TA - Health Qual Life Outcomes JT - Health and quality of life outcomes JID - 101153626 RN - Chinese people SB - IM MH - Humans MH - Female MH - Adolescent MH - *Quality of Life/psychology MH - Male MH - Cross-Sectional Studies MH - China MH - *Life Style MH - *Machine Learning MH - Health Behavior MH - Schools MH - East Asian People PMC - PMC13479416 OTO - NOTNLM OT - Adolescents OT - Family characteristics OT - Health-related quality of life OT - Healthy lifestyle OT - Machine learning OT - School adjustment COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Shandong University [Approval No. 20180517]. Adolescents and their parents/guardians gave informed consent prior to taking part in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/11 06:37 MHDA- 2026/08/17 05:38 PMCR- 2026/06/10 CRDT- 2026/06/11 00:14 PHST- 2026/02/06 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/08/17 05:38 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 00:14 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s12955-026-02568-y [pii] AID - 2568 [pii] AID - 10.1186/s12955-026-02568-y [doi] PST - epublish SO - Health Qual Life Outcomes. 2026 Jun 10;24(1):105. doi: 10.1186/s12955-026-02568-y. PMID- 42271415 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260821 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jun 10 TI - The impacts of caring for children with inherited metabolic diseases for families: a cross-sectional study. LID - 10.1186/s13023-026-04434-y [doi] LID - 286 AB - BACKGROUND: Children with inherited metabolic diseases (IMDs) often have high care needs that require extensive involvement of family caregivers. This study aimed to describe caregiver experiences, including management of children's needs at home, and the impacts of that management on family time, finances, and caregiver and child health-related quality of life (HRQoL). METHODS: In this sub-study within a larger cohort study, participants were family caregivers of children /= 4 extra hours per week assisting their child with care supports at home and 28 reported >/= 6 missed days of work by caregivers in the past year for IMD care. All participants reported fulfillment from caregiving tasks, although 82% reported mental struggles related to caregiving. Based on caregiver reports, children with IMDs had lower HRQoL relative to population normative data. We observed lower median scores for several HRQoL subscales among children with IMDs classified as progressive with multi-system involvement relative to other IMDs. CONCLUSION: We identified important impacts of IMD care for family caregivers. Relief from high levels of caregiving responsibility and time should be a priority for the development of healthcare policies and interventions, to improve health and well-being for both children and their caregivers. CI - (c) 2026. The Author(s). FAU - Chow, Andrea J AU - Chow AJ AUID- ORCID: 0000-0003-1683-2912 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. FAU - Jordan, Isabel AU - Jordan I AD - Patient partner, Squamish, Canada. FAU - Pallone, Nicole AU - Pallone N AD - Patient Partner, Sparwood, Canada. FAU - Smith, Maureen AU - Smith M AUID- ORCID: 0000-0002-2885-7028 AD - Patient Partner, Ottawa, Canada. FAU - Chakraborty, Pranesh AU - Chakraborty P AD - Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada. FAU - Brehaut, Jamie AU - Brehaut J AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. FAU - Chan, Alicia K J AU - Chan AKJ AD - Department of Medical Genetics, University of Alberta, Edmonton, Canada. FAU - Cohen, Eyal AU - Cohen E AUID- ORCID: 0000-0003-0112-7188 AD - Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Canada. FAU - Dyack, Sarah AU - Dyack S AD - Department of Pediatrics, Dalhousie University, Halifax, Canada. FAU - Graham, Ian D AU - Graham ID AUID- ORCID: 0000-0002-3669-1216 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. FAU - Greenberg, Cheryl R AU - Greenberg CR AD - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada. FAU - Hayeems, Robin AU - Hayeems R AD - Child Health Evaluative Sciences, University of Toronto, Hospital for Sick Children, Toronto, Canada. FAU - Inbar-Feigenberg, Michal AU - Inbar-Feigenberg M AUID- ORCID: 0000-0001-8128-5789 AD - Division of Clinical & Metabolic Genetics, The Hospital for Sick Children, Toronto, Canada. FAU - Jain-Ghai, Shailly AU - Jain-Ghai S AD - Department of Medical Genetics, University of Alberta, Edmonton, Canada. FAU - Khangura, Sara AU - Khangura S AUID- ORCID: 0000-0003-0094-6771 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. FAU - MacKenzie, Jennifer J AU - MacKenzie JJ AUID- ORCID: 0000-0002-3374-8619 AD - Department of Medicine, Queen's University, Kingston, Canada. FAU - Major, Nathalie AU - Major N AUID- ORCID: 0000-0003-3655-7460 AD - Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada. FAU - Mitchell, John J AU - Mitchell JJ AD - Montreal Children's Hospital, Montreal, Canada. FAU - Nicholls, Stuart G AU - Nicholls SG AUID- ORCID: 0000-0003-0485-9069 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. AD - Office for Patient Engagement in Research Activities, Ottawa Hospital Research Institute, Ottawa, Canada. FAU - Pender, Amy AU - Pender A AD - Genetics & Metabolics Clinic, McMaster Children's Hospital, Hamilton, Canada. FAU - Potter, Murray AU - Potter M AUID- ORCID: 0000-0003-0577-362X AD - Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada. FAU - Prasad, Chitra AU - Prasad C AD - Department of Pediatrics, Western University, London, Canada. FAU - Schulze, Andreas AU - Schulze A AUID- ORCID: 0000-0001-8491-1095 AD - Division of Clinical & Metabolic Genetics, The Hospital for Sick Children, Toronto, Canada. AD - Department of Biochemistry, University of Toronto, Toronto, Canada. FAU - Siriwardena, Komudi AU - Siriwardena K AD - Department of Medical Genetics, University of Alberta, Edmonton, Canada. FAU - Speechley, Kathy N AU - Speechley KN AUID- ORCID: 0000-0002-5563-2377 AD - Department of Pediatrics, Western University, London, Canada. FAU - Stockler, Sylvia AU - Stockler S AUID- ORCID: 0000-0002-6542-423X AD - BC Children's Hospital, Vancouver, Canada. FAU - Taljaard, Monica AU - Taljaard M AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. FAU - Trakadis, Yannis AU - Trakadis Y AD - Medical Genetics, Montreal Children's Hospital, Montreal, Canada. FAU - Walia, Jagdeep AU - Walia J AD - Department of Pediatrics, Queen's University, Kingston, Canada. FAU - Wilson, Kumanan AU - Wilson K AUID- ORCID: 0000-0002-1741-7705 AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. AD - Department of Medicine, University of Ottawa, Ottawa, Canada. AD - Bruyere Health Research Institute, Ottawa, Canada. FAU - Potter, Beth K AU - Potter BK AUID- ORCID: 0000-0001-8374-6542 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. bpotter@uottawa.ca. LA - eng GR - PJT-153230/CAPMC/CIHR/Canada GR - PJT-153230/CAPMC/CIHR/Canada PT - Journal Article DEP - 20260610 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Female MH - Caregivers/psychology MH - Male MH - Quality of Life MH - *Metabolic Diseases MH - Surveys and Questionnaires MH - Child, Preschool MH - Adult MH - Infant PMC - PMC13487924 OTO - NOTNLM OT - Family-centred care OT - Healthcare management OT - Inherited metabolic diseases OT - Pediatrics OT - Rare diseases COIS- Declarations. Ethics approval and consent to participate: The study received ethics approval from the Children's Hospital of Eastern Ontario Research Ethics Board (CTO Project #1955), the University of Ottawa Research Ethics Board, and the Research Ethics Boards of the eleven participating centres. Written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: MIF has received: grant/research support from Sanofi Genzyme, Shire, Passage Bio, Ultragenyx pharmaceuticals, Denali Therapeutics Inc, Aeglea Biotherapeutics Inc, PTC Therapeutics, Moderna, Vtesse Inc. (Mallinckrodt Pharmaceuticals), conducted research (no funding) with the International Niemann Pick Disease Registry and the MLD Initiative; speaker honoraria from Horizon Therapeutics and the Canadian Fabry Disease Association; consulting fees from Shire, Sanofi Genzyme, Cyclo Therapeutics, and Simon Kutcher; and participated an advisory board of Horizon Therapeutics, Sanofi Genzyme, Shire, Ultragenyx Pharmaceuticals, Alexion Pharmaceuticals, and Recordati Rare Disease. JJ Mitchell has received: educational grants from Biomarin; consulting fees from Ultragenyx, PTC, Biomarin, Takeda, Sanofi, Beam Therapeutics, Moderna; and travel support from Biomarin. SGN received payment from the Health and Medical Research Fund of Hong Kong for peer review of a research study on the Views towards dried blood spot cards storage and its usage for extended genetic testing among parents and healthcare providers in Hong Kong. AP has participated in Dietitian advisory boards for: Ultragenyx (June 2024, April 2022 and March 2021) and Horizon (April 2022 and April 2021). MP is on the advisory board for Ultragenyx, PTC Therapeutics and BioMarin and is the clinical trial site-PI for PTC Therapeutics. KW is the co-founder of CANImmunize Inc and has previously served as a member of the independent safety advisory board for Moderna. The remaining authors have nothing to declare. EDAT- 2026/06/11 06:39 MHDA- 2026/08/19 14:48 PMCR- 2026/06/10 CRDT- 2026/06/11 00:12 PHST- 2025/12/09 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/19 14:48 [medline] PHST- 2026/06/11 06:39 [pubmed] PHST- 2026/06/11 00:12 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s13023-026-04434-y [pii] AID - 4434 [pii] AID - 10.1186/s13023-026-04434-y [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jun 10;21(1):286. doi: 10.1186/s13023-026-04434-y. PMID- 42271359 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260820 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 27 IP - 1 DP - 2026 Jun 10 TI - Modified bone block procedure with periosteal augmentation for peroneal tendon dislocation: a retrospective case series. LID - 10.1186/s12891-026-10053-2 [doi] LID - 706 AB - BACKGROUND: Peroneal tendon dislocation is an uncommon but functionally limiting condition frequently affecting physically active individuals. The standard surgical treatment consists of superior peroneal retinaculum (SPR) repair, with or without fibular groove deepening. However, surgical failure may occur in selected patients with severe SPR deficiency, in whom isolated soft-tissue reconstruction may not provide sufficient mechanical stability. In this context, we therefore developed a modified bone block procedure combined with periosteal augmentation. METHODS: A retrospective case series was conducted including patients with peroneal tendon dislocation who underwent surgical treatment between 2005 and 2025. The procedure consisted of posterior translation and fixation of a contoured fibular bone block based on a modified DuVries osteotomy, combined with reconstruction using an inverted periosteal flap. Clinical outcomes were assessed preoperatively and at final follow-up using the American Orthopaedic Foot and Ankle Society (AOFAS) score, Short Form-12 (SF-12), visual analogue scale (VAS), Manchester-Oxford Foot Questionnaire (MOXFQ), Tegner activity score, and return-to-activity and return-to-sport rates. RESULTS: During the study period, 12 patients underwent surgical treatment for peroneal tendon dislocation. One patient was lost to follow-up, leaving 11 patients in the final cohort. Significant improvements were observed in AOFAS (74.4 +/- 15.2 to 89.7 +/- 12.7, p = .002), SF-12 (89.1 +/- 17.6 to 105.8 +/- 9.7, p = .004), VAS (4.1 +/- 3.4 to 1.5 +/- 2.7, p = .004), MOXFQ scores (35.5 +/- 25.4 to 9.7 +/- 13.9, p = .003) and Tegner score (1.2 +/- 0.6 to 3.4 +/- 1.5, p < .001) at a mean follow-up of 68.2 months. All patients returned to daily activities, and those who participated in sports preoperatively resumed sports. No recurrence occurred. One patient experienced transient sural nerve irritation that resolved without intervention. CONCLUSION: The modified bone block procedure with periosteal augmentation was associated with generally favorable clinical and functional outcomes in this study. This technique may represent a potential surgical option for selected patients with peroneal tendon dislocation, particularly in cases with severe superior peroneal retinaculum insufficiency in which direct SPR repair is not feasible. CI - (c) 2026. The Author(s). FAU - Chen, Po-Yuan AU - Chen PY AD - Department of Orthopedic Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 289, Jianguo Rd., Xindian Dist, New Taipei City, 231016, Taiwan. FAU - Lee, Tung-Ying AU - Lee TY AD - Department of Orthopedic Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 289, Jianguo Rd., Xindian Dist, New Taipei City, 231016, Taiwan. FAU - Yang, Kai-Chiang AU - Yang KC AD - School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan. FAU - Tzeng, I-Shiang AU - Tzeng IS AD - Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, 231016, Taiwan. FAU - Wang, Chen-Chie AU - Wang CC AD - Department of Orthopedic Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 289, Jianguo Rd., Xindian Dist, New Taipei City, 231016, Taiwan. xavier-wang@yahoo.com.tw. AD - Department of Orthopedics, School of Medicine, Tzu Chi University, Hualien, 970473, Taiwan. xavier-wang@yahoo.com.tw. LA - eng PT - Journal Article DEP - 20260610 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - Retrospective Studies MH - Female MH - Male MH - *Tendon Injuries/surgery/diagnostic imaging MH - *Joint Dislocations/surgery/diagnostic imaging MH - Adult MH - Treatment Outcome MH - Young Adult MH - *Periosteum/surgery MH - *Osteotomy/methods MH - Adolescent MH - *Plastic Surgery Procedures/methods MH - Follow-Up Studies MH - *Ankle Injuries/surgery MH - Fibula/surgery PMC - PMC13483641 OTO - NOTNLM OT - Ankle injuries OT - Ankle surgery OT - Bone block method OT - Foot surgery OT - Peroneal tendon dislocation OT - Superior peroneal retinaculum COIS- Declarations. Ethics approval and consent to participate: This retrospective study was approved by the Institutional Review Board of Taipei Tzu Chi Hospital (approval number: 14-IRB132) and was conducted in accordance with the principles of the Declaration of Helsinki. The requirement for written informed consent was waived by the Institutional Review Board due to the retrospective nature of the study and the use of anonymized clinical data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/11 06:39 MHDA- 2026/08/18 07:46 PMCR- 2026/06/10 CRDT- 2026/06/11 00:10 PHST- 2026/02/24 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/08/18 07:46 [medline] PHST- 2026/06/11 06:39 [pubmed] PHST- 2026/06/11 00:10 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s12891-026-10053-2 [pii] AID - 10053 [pii] AID - 10.1186/s12891-026-10053-2 [doi] PST - epublish SO - BMC Musculoskelet Disord. 2026 Jun 10;27(1):706. doi: 10.1186/s12891-026-10053-2. PMID- 42270889 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1179-2019 (Electronic) IS - 1174-5878 (Print) IS - 1174-5878 (Linking) VI - 28 IP - 4 DP - 2026 Jul TI - Discontinuing Colchicine in Pediatric Familial Mediterranean Fever: Real-Life Experience from a Long-Term Follow-Up Cohort. PG - 405-415 LID - 10.1007/s40272-026-00755-4 [doi] AB - BACKGROUND: Colchicine is the cornerstone of treatment in familial Mediterranean fever and is generally recommended as lifelong therapy. However, a subset of pediatric patients may experience a milder disease course, raising questions about the feasibility and safety of colchicine discontinuation. Evidence guiding this decision remains limited, and no consensus exists on patient selection criteria or monitoring strategies. OBJECTIVE: The objective of this study was to evaluate long-term outcomes after colchicine discontinuation in a large pediatric familial Mediterranean fever cohort and to identify clinical and genetic factors associated with sustained colchicine-free remission. METHODS: We retrospectively analyzed medical records of 2316 pediatric patients diagnosed with familial Mediterranean fever and followed at the Pediatric Rheumatology Unit of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkiye. Patients fulfilling at least one of the Tel-Hashomer or Eurofever/Pediatric Rheumatology International Trials Organization (PRINTO) classification criteria and carrying at least one pathogenic or likely pathogenic MEFV (Mediterranean fever) gene mutation were eligible. Colchicine was discontinued in 127 patients (5.48%), who were classified into two groups: Group 1 (n = 31), patients who required colchicine re-initiation because of recurrent attacks, and Group 2 (n = 96), patients who maintained sustained colchicine-free remission during follow-up. A contemporaneous comparator group of 118 patients who continued colchicine therapy without any attempt at discontinuation (Group 3) was included to provide clinical and genetic context. Demographic, clinical, genetic, and disease severity characteristics were compared across groups. RESULTS: Sustained colchicine-free remission was maintained in 96 of 2316 patients (4.14%; Group 2). Among all patients who discontinued colchicine (Groups 1 and 2 combined), the median duration of colchicine treatment before discontinuation was 3.85 years (interquartile range 1.84-7.10), and the median follow-up after cessation was 4.91 years (interquartile range 1.92-7.23). Baseline clinical, demographic, and genetic characteristics were largely similar between Group 1 and Group 2, and no robust independent predictor of sustained remission was identified. Biallelic pathogenic exon 10 MEFV variants were significantly more prevalent in Group 3 (32.2%) compared with Group 1 (12.9%) and Group 2 (3.1%), reflecting a progressive genetic gradient across the three groups. Patients in Group 3 also exhibited higher frequencies of fever, chest pain, arthritis, arthralgia, erysipelas-like erythema, and exercise-induced leg pain compared with the discontinuation groups. Fulfillment of Eurofever/PRINTO classification criteria was significantly lower in Groups 1 (54.8%) and 2 (54.2%) than in Group 3 (87.3%), consistent with a milder phenotypic profile in patients considered for discontinuation. No patient in the discontinuation cohort developed amyloidosis during follow-up. CONCLUSIONS: Colchicine discontinuation is achievable in a small but consistent subset of patients with pediatric familial Mediterranean fever (4.14% of the total cohort), the majority of whom maintain sustained remission over a long-term follow-up. While patients requiring continuous therapy exhibit a more severe clinical and genetic profile, no robust baseline predictor reliably distinguishes those who will remain in remission from those who will relapse. These findings highlight the need for individualized withdrawal decisions guided by rigorous longitudinal monitoring, and underscore the importance of prospective studies incorporating emerging biomarkers of subclinical inflammation. CI - (c) 2026. The Author(s). FAU - Arik, Selen Duygu AU - Arik SD AUID- ORCID: 0000-0001-7648-1195 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Kayaalp, Gulsah Kavrul AU - Kayaalp GK AUID- ORCID: 0000-0001-7490-7076 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Kilinc, Aysenur Dogru AU - Kilinc AD AUID- ORCID: 0000-0001-8091-8417 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Menentoglu, Bengisu AU - Menentoglu B AUID- ORCID: 0000-0003-2774-9591 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Taskin, Busra Baser AU - Taskin BB AUID- ORCID: 0009-0003-5097-4479 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Dudakli, Asli AU - Dudakli A AUID- ORCID: 0000-0001-5454-0182 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Tanatar, Ayse AU - Tanatar A AUID- ORCID: 0000-0002-1386-4575 AD - Department of Pediatric Rheumatology, Ministry of Health Marmara University, Pendik Training and Research Hospital, Istanbul, Turkey. FAU - Akgun, Ozlem AU - Akgun O AUID- ORCID: 0000-0001-7216-0562 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Ayaz, Nuray Aktay AU - Ayaz NA AUID- ORCID: 0000-0003-3594-7387 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. nurayaktay@gmail.com. LA - eng PT - Journal Article DEP - 20260610 PL - Switzerland TA - Paediatr Drugs JT - Paediatric drugs JID - 100883685 RN - SML2Y3J35T (Colchicine) RN - 0 (Pyrin) RN - 0 (MEFV protein, human) SB - IM MH - Humans MH - *Colchicine/administration & dosage/therapeutic use MH - *Familial Mediterranean Fever/drug therapy/genetics MH - Female MH - Child MH - Retrospective Studies MH - Male MH - Follow-Up Studies MH - Adolescent MH - Child, Preschool MH - Pyrin/genetics MH - Mutation MH - Remission Induction MH - Treatment Interruption MH - Treatment Outcome PMC - PMC13379450 COIS- Declarations. Conflicts of Interest/Competing Interests: Selen Duygu Arik, Gulsah Kavrul Kayaalp, Aysenur Dogru Kilinc, Bengisu Menentoglu, Busra Baser Taskin, Asli Dudakli, Ayse Tanatar, Ozlem Akgun, and Nuray Aktay Ayaz have no conflicts of interest that are directly relevant to the content of this article. Ethics Approval: The study was approved by the Ethical Committee of Istanbul University, Istanbul Medicinal Faculty (date: 05.02.2024; No: 2405744). The study was carried out and complied with the Declaration of Helsinki. Consent to Participate: Written informed consent was obtained from all patients and/or their parents or legal guardians prior to inclusion in this study. Consent for Publication: Not applicable. Availability of Data and Material: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request. Code Availability: Not applicable. Authors' Contributions: All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by SDA, OA, and NAA. The first draft of the manuscript was written by SDA, and all authors commented on earlier versions. All authors read and approved the final manuscript. EDAT- 2026/06/11 05:43 MHDA- 2026/07/17 19:17 PMCR- 2026/06/10 CRDT- 2026/06/10 23:29 PHST- 2026/02/25 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/07/17 19:17 [medline] PHST- 2026/06/11 05:43 [pubmed] PHST- 2026/06/10 23:29 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1007/s40272-026-00755-4 [pii] AID - 755 [pii] AID - 10.1007/s40272-026-00755-4 [doi] PST - ppublish SO - Paediatr Drugs. 2026 Jul;28(4):405-415. doi: 10.1007/s40272-026-00755-4. Epub 2026 Jun 10. PMID- 42270572 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260911 IS - 1473-2300 (Electronic) IS - 0300-0605 (Print) IS - 0300-0605 (Linking) VI - 54 IP - 6 DP - 2026 Jun TI - Evaluation of body mass index, waist-to-hip ratio, and waist-to-height ratio as predictors of insulin resistance in Syrian adult women: A cross-sectional study. PG - 3000605261455139 LID - 10.1177/03000605261455139 [doi] LID - 03000605261455139 AB - ObjectiveBody mass index, waist-to-hip ratio, and waist-to-height ratio are widely used anthropometric indices for assessing obesity-related metabolic risk; however, their relative contributions to insulin resistance remain debated and vary across different ethnicities.MethodsThis prospective cross-sectional study evaluated the correlations of body mass index, waist-to-hip ratio, and waist-to-height ratio with insulin resistance, measured by the homeostasis model assessment of insulin resistance, among 70 Syrian adult women aged 17-46 years who were consecutively recruited from the outpatient clinic in Homs governorate.ResultsScatter plots and correlation analyses were performed indicating that different anthropometric parameters are associated, to varying degrees, with the occurrence and progression of insulin resistance. Among studied anthropometric obesity indicators, body mass index has a weak, non-significant correlation with homeostasis model assessment of insulin resistance (r = 0.18, p = 0.1338), whereas waist-to-height ratio (r = 0.62, p = 0.0001) was found to be the most closely associated with occurrence of insulin resistance. Receiver operating characteristic analysis further demonstrated that waist-to-height ratio had the highest predictive accuracy for insulin resistance (area under the curve = 0.82), outperforming body mass index (area under the curve = 0.78) and waist-to-hip ratio (area under the curve = 0.74).ConclusionTherefore, waist-to-height ratio appears to be a simple and effective anthropometric tool for identifying individuals at higher risk of insulin resistance in Syrian adult women. However, as our study was only conducted on women, further investigations in men are warranted to justify its widespread adoption in clinical practice. FAU - Zam, Wissam AU - Zam W AUID- ORCID: 0000-0002-2733-1884 AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Tartous University, Syria. AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Al-Wadi International University, Syria. FAU - Farkoh, Haya AU - Farkoh H AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Al-Wadi International University, Syria. FAU - Makhoul, Jana AU - Makhoul J AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Al-Wadi International University, Syria. FAU - Youssef, Jouel AU - Youssef J AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Al-Wadi International University, Syria. LA - eng PT - Journal Article DEP - 20260610 PL - England TA - J Int Med Res JT - The Journal of international medical research JID - 0346411 SB - IM MH - Humans MH - Female MH - *Insulin Resistance MH - *Waist-Hip Ratio MH - *Body Mass Index MH - Cross-Sectional Studies MH - Adult MH - *Waist-Height Ratio MH - Syria/epidemiology MH - Middle Aged MH - Prospective Studies MH - Adolescent MH - Young Adult MH - *Obesity/diagnosis/physiopathology MH - ROC Curve PMC - PMC13554508 OTO - NOTNLM OT - Body mass index OT - Syrian adult women OT - homeostasis model assessment of insulin resistance OT - waist-to-height ratio OT - waist-to-hip ratio COIS- Declaration of conflicting interestsThe authors declare no potential conflicts of interest. EDAT- 2026/06/11 05:42 MHDA- 2026/06/12 18:41 PMCR- 2026/06/10 CRDT- 2026/06/10 22:52 PHST- 2026/06/12 18:41 [medline] PHST- 2026/06/11 05:42 [pubmed] PHST- 2026/06/10 22:52 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1177_03000605261455139 [pii] AID - 10.1177/03000605261455139 [doi] PST - ppublish SO - J Int Med Res. 2026 Jun;54(6):3000605261455139. doi: 10.1177/03000605261455139. Epub 2026 Jun 10. PMID- 42270539 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260624 IS - 2341-2879 (Electronic) IS - 2341-2879 (Linking) VI - 104 IP - 6 DP - 2026 Jun TI - Neck circumference in screening for elevated blood pressure. PG - 504226 LID - S2341-2879(26)00183-3 [pii] LID - 10.1016/j.anpede.2026.504226 [doi] AB - INTRODUCTION: Elevated blood pressure (EBP) in childhood is associated with excess adiposity. The aim was to compare anthropometric and body composition indicators to identify EBP (>/=90th percentile) in schoolchildren. MATERIALS AND METHODS: Cross-sectional study in 497 rural Andalusian schoolchildren (6-15 years). Weight, height, circumferences (waist and neck) and skinfolds (bicipital, tricipital, subscapular, and suprailiac) were recorded to calculate body mass index, waist-to-height ratio, the sum of 4 skinfolds and body fat percentage. Blood pressure was measured by oscillometry (3 readings; mean of the last 2) and classified using Spanish age- and sex-specific references (>/=90th percentile for systolic and/or diastolic blood pressure). Age- and sex-adjusted logistic models and sex-stratified analyses of discrimination and calibration were performed; optimal cut-offs were derived using the Youden index. RESULTS: The prevalence of EBP was 5.8% and increased with excess weight, particularly in girls. After multivariable adjustment, neck circumference (NC) was the indicator most consistently associated with EBP. Discriminative ability was moderate in boys and high in girls, with optimal cut-offs of 29.15 cm and 30.65 cm, respectively. CONCLUSIONS: NC is a simple, low-cost measure that may complement traditional indicators for EBP screening in school settings and primary care; the proposed cut-offs require external validation. CI - Copyright (c) 2026 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Recio Anon, Carlos AU - Recio Anon C AD - Dispositivo de Cuidados Criticos y Urgencias, Distrito Sanitario Cordoba Guadalquivir, Cordoba, Spain; Grupo de Investigacion EPINUT Ref. 929325, Universidad Complutense de Madrid, Madrid, Spain. Electronic address: crecio02@ucm.es. FAU - Sastre Dominguez, Manuel Alejandro AU - Sastre Dominguez MA AD - Servicio de Pediatria, Hospital Universitario Reina Sofia de Cordoba, Cordoba, Spain. FAU - Carracedo Anon, Julia AU - Carracedo Anon J AD - Departamento de Genetica, Fisiologia y Microbiologia, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria Hospital 12 de Octubre (IMAS12), Madrid, Spain. FAU - Gonzalez Martin, Antonio AU - Gonzalez Martin A AD - Departamento de Biodiversidad, Ecologia y Evolucion, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Madrid, Spain. FAU - Marrodan Serrano, Maria Dolores AU - Marrodan Serrano MD AD - Grupo de Investigacion EPINUT Ref. 929325, Universidad Complutense de Madrid, Madrid, Spain; Departamento de Biodiversidad, Ecologia y Evolucion, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260610 PL - Spain TA - An Pediatr (Engl Ed) JT - Anales de pediatria JID - 101765626 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - *Neck/anatomy & histology MH - Female MH - Child MH - *Hypertension/diagnosis/epidemiology MH - Adolescent MH - Mass Screening/methods OTO - NOTNLM OT - Anthropometry OT - Antropometria OT - Blood pressure OT - Cuello OT - Neck OT - Obesidad infantil OT - Pediatric obesity OT - Pediatrics OT - Pediatria OT - Presion arterial COIS- Declaration of competing interest The authors have no conflicts of interest to declare. EDAT- 2026/06/11 05:42 MHDA- 2026/06/25 00:33 CRDT- 2026/06/10 22:51 PHST- 2026/02/04 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/11 05:42 [pubmed] PHST- 2026/06/10 22:51 [entrez] AID - S2341-2879(26)00183-3 [pii] AID - 10.1016/j.anpede.2026.504226 [doi] PST - ppublish SO - An Pediatr (Engl Ed). 2026 Jun;104(6):504226. doi: 10.1016/j.anpede.2026.504226. Epub 2026 Jun 10. PMID- 42269963 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260821 IS - 1878-1780 (Electronic) IS - 1262-3636 (Linking) VI - 52 IP - 4 DP - 2026 Jul TI - Persistent burden and management gaps of hypoglycemia in pediatric type 1 diabetes: insights from the Epi-GLUREDIA Study. PG - 101774 LID - S1262-3636(26)00053-4 [pii] LID - 10.1016/j.diabet.2026.101774 [doi] AB - BACKGROUND/OBJECTIVES: - Despite advances in automated insulin delivery, hypoglycemia remains a major challenge in pediatric type 1 diabetes. We aimed to characterize, in real-world practice, the burden, awareness, and daily-life impact of hypoglycemia and severe hypoglycemia (SH), and to identify gaps in perception and management. METHODS: - We conducted a prospective, descriptive, multicenter study using the new GLUREDIA questionnaire, administered during routine pediatric diabetes visits across six centers in Belgium and Luxembourg. This structured, study-specific, semi-quantitative tool assessed hypoglycemia frequency, symptom severity, perceived glycemic thresholds, SH history and management, and post-SH behavioral adaptations. Hypoglycemia awareness was evaluated using items aligned with Clarke score domains. RESULTS: - Among 232 participants, 55.9% reported hypoglycemia at least weekly, with moderate-to-high symptom severity. Cognitive and daily-life symptoms (impaired focus, fatigue, hunger, tremor) were reported by >60% and interfered with activities. Hypoglycemia was identified as the dominant disease burden by 39.7% of participants. Hypoglycemia-related symptom burden remained substantial and was not fully explained by CGM-derived metrics. SH was reported by 45.7%, without clear cause in 29.1%. Recommended management, including glucagon use, was inconsistently applied, even in recurrent SH. Following SH, participants reported insulin dose reductions (27.4%), increased sugar intake (21.1%), and avoidance of physical activities (22.1%), as adaptations. The Epi-GLUREDIA questionnaire demonstrated promising discriminative ability against the Clarke score (AUC = 0.84), supporting its construct validity. CONCLUSIONS: - Despite advances in diabetes technology, hypoglycemia remains highly prevalent, impactful, and often poorly anticipated in pediatric type 1 diabetes. Gaps in SH management and hypoglycemia awareness, together with post-event adaptations, highlight the need for integrated strategies combining education, behavioral support, optimized use of technologies, and improved implementation of guidelines, including appropriate glucagon use, to improve hypoglycemia safety, recognition, and long-term outcomes in pediatric type 1 diabetes. SUMMARY: Hypoglycemia remains frequent and impactful in pediatric type 1 diabetes, with variable symptom thresholds, unexplained severe hypoglycemia, management gaps, and post-event adaptations that may impair glycemic control. CI - Copyright (c) 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved. FAU - Beckers, Maude AU - Beckers M AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. FAU - Harvengt, Antoine AU - Harvengt A AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. FAU - Schoenmaeckers, Gaetan de Valensart AU - Schoenmaeckers GV AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium. FAU - Beckers, Dominique AU - Beckers D AD - Pediatric Endocrinology and Diabetology, CHU UCL Namur, Rue Dr Gaston Therasse 1, 5530 Yvoir. FAU - Boutsen, Laure AU - Boutsen L AD - Pediatric Endocrinology and Diabetology, CHU UCL Namur, Rue Dr Gaston Therasse 1, 5530 Yvoir; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. FAU - Mouraux, Thierry AU - Mouraux T AD - Pediatric Endocrinology and Diabetology, CHU UCL Namur, Rue Dr Gaston Therasse 1, 5530 Yvoir. FAU - Gies, Inge AU - Gies I AD - Pediatric Department, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Vitality Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels. FAU - Staels, Willem AU - Staels W AD - Pediatric Department, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Beta Cell Neogenesis (BENE) research group, Genetics Reproduction and Development (GRAD), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels. FAU - Vanbesien, Jesse AU - Vanbesien J AD - Pediatric Department, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Vitality Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels. FAU - Lysy, Philippe A AU - Lysy PA AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. Electronic address: philippe.lysy@uclouvain.be. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260610 PL - France TA - Diabetes Metab JT - Diabetes & metabolism JID - 9607599 RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Cost of Illness MH - *Diabetes Mellitus, Type 1/drug therapy/complications/blood MH - *Hypoglycemia/epidemiology/chemically induced/therapy MH - *Hypoglycemic Agents/adverse effects/therapeutic use/administration & dosage MH - Insulin/adverse effects/administration & dosage/therapeutic use MH - Prospective Studies MH - Surveys and Questionnaires OTO - NOTNLM OT - Adolescents/Children OT - Glucagon OT - Hypoglycemia OT - Hypoglycemia Awareness OT - Pediatric Diabetes OT - Severe Hypoglycemia OT - Type 1 Diabetes COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Philippe A. Lysy reports financial support was provided by The Leona M and Harry B Helmsley Charitable Trust. Maude Beckers reports financial support was provided by Fund for Scientific Research. Philippe A. Lysy reports financial support was provided by Saint-Luc Foundation. Willem Staels reports a relationship with Research Foundation Flanders that includes: funding grants. Willem Staels reports a relationship with Breakthrough T1D that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/11 05:41 MHDA- 2026/07/25 00:35 CRDT- 2026/06/10 19:58 PHST- 2026/04/02 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/25 00:35 [medline] PHST- 2026/06/11 05:41 [pubmed] PHST- 2026/06/10 19:58 [entrez] AID - S1262-3636(26)00053-4 [pii] AID - 10.1016/j.diabet.2026.101774 [doi] PST - ppublish SO - Diabetes Metab. 2026 Jul;52(4):101774. doi: 10.1016/j.diabet.2026.101774. Epub 2026 Jun 10. PMID- 42269926 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260702 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 74 DP - 2026 Aug TI - Age-dependent diagnostic performance of mid-upper arm circumference Z-score in pediatric neurology: A multicenter study with a cerebral palsy subgroup. PG - 103388 LID - S2405-4577(26)00485-7 [pii] LID - 10.1016/j.clnesp.2026.103388 [doi] AB - BACKGROUND: Malnutrition is a common but frequently underrecognized comorbidity in children with neurological disorders. Accurate nutritional assessment is often challenging in pediatric neurology practice due to motor impairment, skeletal deformities, and unreliable height and weight measurements. Mid-upper arm circumference Z-score (MUAC-Z) has emerged as a practical anthropometric alternative; however, its age-dependent diagnostic performance in neurologically affected children remains insufficiently defined. OBJECTIVE: To evaluate the age-specific diagnostic accuracy of MUAC-Z for detecting malnutrition in a large pediatric neurology outpatient cohort and in a predefined subgroup of children with cerebral palsy (CP). METHODS: This multicenter, analytical cross-sectional study included 3668 children aged 6 months to 19 years attending pediatric neurology outpatient clinics, including 242 children with CP. Participants were stratified into two age groups (6-60 months and 5-19 years). Malnutrition was defined as weight-for-age Z-score (WAZ) < -2 in children under 5 years and body mass index-for-age Z-score (BMI-Z) < -2 in older children. Anthropometric measurements, laboratory parameters, and enteral feeding status were recorded. Diagnostic performance of MUAC-Z was assessed using receiver operating characteristic (ROC) curve analysis. RESULTS: MUAC-Z demonstrated moderate diagnostic accuracy in children aged 6-60 months (AUC 0.772), with marked variability across early childhood subgroups. In contrast, MUAC-Z showed excellent diagnostic performance in children aged 5-19 years (AUC 0.907). In the CP subgroup, malnutrition prevalence was substantially higher across all indices. MUAC-Z showed limited accuracy in CP children under 5 years (AUC 0.668) but good diagnostic performance in those aged 5-19 years (AUC 0.774). Older malnourished children, particularly those with CP, exhibited more frequent laboratory abnormalities consistent with chronic nutritional impairment. CONCLUSIONS: The diagnostic utility of MUAC-Z in pediatric neurology is strongly age-dependent. MUAC-Z represents a reliable and practical screening tool in school-aged children and adolescents, including those with cerebral palsy, while its use in early childhood should be complementary to conventional anthropometric indices. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Dilber, Beril AU - Dilber B AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: berildilber@ktu.edu.tr. FAU - Kucukali̇oglu, Burcu Pariltan AU - Kucukali̇oglu BP AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: bpariltankucukalioglu@gmail.com. FAU - Emral, Hasan AU - Emral H AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: hasanemral.md@gmail.com. FAU - Cansu, Ali AU - Cansu A AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: acansu2011@hotmail.com. FAU - Sahin, Sevim AU - Sahin S AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: sevimsahin1@yahoo.com. FAU - Tekin, Emine AU - Tekin E AD - Department of Pediatric Neurology, Faculty of Medicine, Giresun University, Giresun, Turkiye. Electronic address: dreminetekin@yahoo.com. FAU - Di̇ler Durgut, Betul AU - Di̇ler Durgut B AD - Department of Pediatric Neurology, Faculty of Medicine, Giresun University, Giresun, Turkiye. Electronic address: betuldlr@hotmail.com. FAU - Ozkan Kart, Pinar AU - Ozkan Kart P AD - Department of Pediatric Neurology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkiye. Electronic address: drpinar_ozkan@yahoo.com. FAU - Hanci, Fatma AU - Hanci F AD - Department of Pediatric Neurology, Faculty of Medicine, Trabzon University, Trabzon, Turkiye. Electronic address: fatmah.arslan@gmail.com. FAU - Esenulku, Gulnur AU - Esenulku G AD - Department of Pediatric Neurology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkiye. Electronic address: drgesenulku@gmail.com. FAU - Bulut, Tuba AU - Bulut T AD - Department of Pediatric Neurology, Hatay Training and Research Hospital, Hatay, Turkiye. Electronic address: tubaa_bulut@hotmail.com. FAU - Ozpinar, Esra AU - Ozpinar E AD - Department of Pediatric Neurology, Faculty of Medicine, Hatay Mustafa Kemal University Hospital, Hatay, Turkiye. Electronic address: dr.esraozpinar@gmail.com. FAU - Kilic, Betul AU - Kilic B AD - Department of Pediatric Neurology, Faculty of Medicine, Medipol University Hospital, Istanbul, Turkiye. FAU - Topcu, Yasemin AU - Topcu Y AD - Department of Pediatric Neurology, Faculty of Medicine, Medipol University Hospital, Istanbul, Turkiye. Electronic address: yasmintopcu35@gmail.com. FAU - Aydin, Kursad AU - Aydin K AD - Department of Pediatric Neurology, Faculty of Medicine, Medipol University Hospital, Istanbul, Turkiye. Electronic address: kursadaydin@hotmail.com. FAU - Oz Dagdelen, Zeynep AU - Oz Dagdelen Z AD - Department of Pediatric Neurology, Istanbul Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkiye. Electronic address: zeynep._oz@hotmail.com. FAU - Akyuz Yucel, Gulcan AU - Akyuz Yucel G AD - Department of Pediatric Neurology, Istanbul Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkiye. Electronic address: gulcan.akyuz@hotmail.com. FAU - Baykan, Muge AU - Baykan M AD - Department of Pediatric Neurology, Recep Tayyip Erdogan University Rize Training and Research Hospital, Rize, Turkiye. Electronic address: dr.mugebaykan@gmail.com. FAU - Cetin, Huriye AU - Cetin H AD - Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Ankara, Turkiye. Electronic address: huriyeecetin@gmail.com. FAU - Tas, Elif Nalan AU - Tas EN AD - Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Ankara, Turkiye. Electronic address: en_kibarkaya@icloud.com. FAU - Petek Arhan, Ebru AU - Petek Arhan E AD - Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Ankara, Turkiye. Electronic address: ebruarhan@gazi.edu.tr. FAU - Demir, Ercan AU - Demir E AD - Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Ankara, Turkiye. Electronic address: ercandemir@gazi.edu.tr. FAU - Tutuncu Toker, Rabia AU - Tutuncu Toker R AD - Department of Pediatric Neurology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkiye. Electronic address: rabiatoker@uludag.edu.tr. FAU - Doganc, Tugba AU - Doganc T AD - Department of Pediatric Neurology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkiye. Electronic address: tugbadoganc@uludag.edu.tr. FAU - Turkmen, Dilek AU - Turkmen D AD - Department of Pediatric Neurology, Faculty of Medicine, Erciyes University Hospital, Kayseri, Turkiye. Electronic address: dilek_bldk@hotmail.com. FAU - Per, Huseyin AU - Per H AD - Department of Pediatric Neurology, Faculty of Medicine, Erciyes University Hospital, Kayseri, Turkiye. Electronic address: huseyinper@yahoo.com. FAU - Ayanoglu, Muge AU - Ayanoglu M AD - Department of Pediatric Neurology, Faculty of Medicine, Aydin Adnan Menderes University Hospital, Aydin, Turkiye. Electronic address: mugeayanoglu_05@hotmail.com. FAU - Kamasak, Tulay AU - Kamasak T AD - Department of Pediatric Neurology, Faculty of Medicine, Aydin Adnan Menderes University Hospital, Aydin, Turkiye. Electronic address: tkamasak@hotmail.com. FAU - Guven, Burcu AU - Guven B AD - Department of Pediatric Gastroenterology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: burcuguven55@gmail.com. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260610 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - Child, Preschool MH - Child MH - Adolescent MH - *Cerebral Palsy/complications/diagnosis MH - Infant MH - Cross-Sectional Studies MH - Male MH - Female MH - *Arm MH - *Malnutrition/diagnosis/epidemiology MH - *Anthropometry/methods MH - Nutrition Assessment MH - Age Factors MH - Nutritional Status MH - Young Adult MH - Body Mass Index MH - ROC Curve OTO - NOTNLM OT - Anthropometry OT - Cerebral palsy OT - MUAC-Z OT - Malnutrition OT - Mid-upper arm circumference OT - Nutritional screening OT - Pediatric neurology COIS- Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/11 05:42 MHDA- 2026/06/27 00:57 CRDT- 2026/06/10 19:58 PHST- 2026/02/24 00:00 [received] PHST- 2026/04/26 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/06/27 00:57 [medline] PHST- 2026/06/11 05:42 [pubmed] PHST- 2026/06/10 19:58 [entrez] AID - S2405-4577(26)00485-7 [pii] AID - 10.1016/j.clnesp.2026.103388 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Aug;74:103388. doi: 10.1016/j.clnesp.2026.103388. Epub 2026 Jun 10. PMID- 42269380 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1618-131X (Electronic) IS - 1438-4639 (Linking) VI - 276 DP - 2026 Jul TI - Uncovering hidden beta-adrenergic agonist exposure from meat consumption through nationally representative human biomonitoring in Taiwan. PG - 114849 LID - S1438-4639(26)00109-4 [pii] LID - 10.1016/j.ijheh.2026.114849 [doi] AB - BACKGROUND: Despite stringent bans on clenbuterol in livestock production, its prolonged half-life poses a potential risk for human bioaccumulation. Conversely, legally permitted additives like ractopamine undergo rapid metabolism. This study utilized human biomonitoring (HBM) to uncover hidden beta-adrenergic agonist exposures in Taiwan, contrasting internal body burdens with traditional market surveillance data. METHODS: We analyzed data from a nationally representative sample of 1554 participants in the 2019 Taiwan Human BioMonitoring Program. Spot urine samples were tested for eight beta-adrenergic agonists using ultra-trace isotope dilution online SPE-LC-MS/MS. Dietary habits, including meat and egg consumption frequencies, were assessed via validated food frequency questionnaires. Associations were evaluated using survey-weighted logistic regression models. RESULTS: Clenbuterol was the most frequently detected beta-adrenergic agonist (31.4%), starkly contrasting with its zero-detection rate in recent official market surveillance. In contrast, the legally permitted ractopamine was detected in only 4.2% of samples. After adjusting for confounders, urinary clenbuterol detection showed a significant association with red meat consumption (adjusted odds ratio = 1.39, 95% CI: 1.08-1.79, p = 0.011). CONCLUSIONS: A significant portion of the Taiwanese general population experiences hidden, low-dose exposure to clenbuterol. This prevalence highlights a critical gap between routine regulatory testing limits and the bioaccumulation potential of clenbuterol from red meat consumption. HBM proves essential for uncovering these hidden exposures. Integrating ultra-trace HBM data into public health frameworks is necessary to accurately assess dietary risks and effectively manage food safety policies. CI - Copyright (c) 2026 Elsevier GmbH. All rights reserved. FAU - Liao, Ho-Tang AU - Liao HT AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. FAU - Peng, Tzu-Hsuan AU - Peng TH AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan. FAU - Wang, Chien-Jen AU - Wang CJ AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. FAU - Hsu, Jing-Fang AU - Hsu JF AD - Department of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan; Department of Occupational Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan. FAU - Lin, Ching-Chun AU - Lin CC AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan. FAU - Pan, Wen-Harn AU - Pan WH AD - College of Public Health, Taipei Medical University, New Taipei, Taiwan. FAU - Chia, Shu-Lih AU - Chia SL AD - Ministry of Health and Welfare, Taipei, Taiwan. FAU - Chen, Pau-Chung AU - Chen PC AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan. Electronic address: pchen@ntu.edu.tw. LA - eng PT - Journal Article DEP - 20260610 PL - Germany TA - Int J Hyg Environ Health JT - International journal of hygiene and environmental health JID - 100898843 RN - 0 (Adrenergic beta-Agonists) RN - XTZ6AXU7KN (Clenbuterol) RN - 57370OZ3P1 (ractopamine) RN - 0 (Phenethylamines) SB - IM MH - Humans MH - *Adrenergic beta-Agonists/urine MH - Taiwan MH - Biological Monitoring MH - Female MH - Adult MH - Male MH - *Meat MH - Middle Aged MH - Clenbuterol/urine MH - Food Contamination/analysis MH - Young Adult MH - *Dietary Exposure/analysis MH - Aged MH - Phenethylamines/urine MH - Adolescent MH - Environmental Exposure OTO - NOTNLM OT - Dietary exposure OT - General population OT - Human biomonitoring OT - Leanness-enhancing agent OT - beta-adrenergic agonist COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2026/06/11 05:43 MHDA- 2026/07/23 05:36 CRDT- 2026/06/10 18:06 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/30 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/23 05:36 [medline] PHST- 2026/06/11 05:43 [pubmed] PHST- 2026/06/10 18:06 [entrez] AID - S1438-4639(26)00109-4 [pii] AID - 10.1016/j.ijheh.2026.114849 [doi] PST - ppublish SO - Int J Hyg Environ Health. 2026 Jul;276:114849. doi: 10.1016/j.ijheh.2026.114849. Epub 2026 Jun 10. PMID- 42269336 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 1878-9307 (Electronic) IS - 1878-9293 (Print) IS - 1878-9293 (Linking) VI - 80 DP - 2026 Aug TI - ABCD-ReproNim: An educational program for responsible and reproducible analyses of ABCD data. PG - 101755 LID - S1878-9293(26)00092-7 [pii] LID - 10.1016/j.dcn.2026.101755 [doi] LID - 101755 AB - ABCD-ReproNim is a research educational course that provides training in responsible and reproducible analyses of data from the Adolescent Brain Cognitive Development (ABCD) Study. ABCD-ReproNim was established in 2020 and structured as a collaborative partnership between ABCD investigators and ReproNim, a NIBIB-funded P41 center for reproducible neuroimaging whose vision is to help researchers achieve more reproducible data analysis workflows and outcomes. With over 1.1 K registered students and > 18 K YouTube views, ABCD-ReproNim has been well-received by the community and is providing ABCD data training while promoting skill development in reproducible analyses that support efficient, re-executable design and FAIR practices. Participants first receive didactic training across a semester-long online course that includes lectures, readings, and data exercises. We use an innovative curricular approach that is grounded in modern, transformational methods of STEM pedagogy, which includes philosophies and features drawn from active learning, inverted classrooms, and hack weeks. At the completion of the course, participants contribute to team-based, collaborative data analysis projects during an in-person hackathon at the host institution, Florida International University, in Miami, Florida. Through this research educational program, we provide (i) a comprehensive understanding of the ABCD dataset; (ii) instructional techniques that enhance the validity and reproducibility of research methods; (iii) support of interdisciplinary, team-based collaborations; and (iv) dissemination of the course, project materials, and research findings. Our overall goal is to contribute to the generation of a cadre of investigators that are well trained in the techniques that support responsible, reproducible, and valid analyses of ABCD data. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Laird, Angela R AU - Laird AR AD - Department of Physics, Florida International University, Miami, FL, USA. Electronic address: alaird@fiu.edu. FAU - Bartley, Jessica E AU - Bartley JE AD - Department of Physics, Florida International University, Miami, FL, USA. FAU - Peraza, Julio A AU - Peraza JA AD - Department of Physics, Florida International University, Miami, FL, USA. FAU - Poline, Jean-Baptiste AU - Poline JB AD - McConnell Brain Imaging Centre, The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada. FAU - Ghosh, Satrajit S AU - Ghosh SS AD - McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA. FAU - Kennedy, David N AU - Kennedy DN AD - Departments of Psychiatry and Radiology, University of Massachusetts Chan Medical School, Worcester, MA, USA. LA - eng PT - Journal Article DEP - 20260605 PL - Netherlands TA - Dev Cogn Neurosci JT - Developmental cognitive neuroscience JID - 101541838 SB - IM MH - Humans MH - Reproducibility of Results MH - Adolescent MH - *Adolescent Development/physiology MH - *Neuroimaging MH - *Brain/diagnostic imaging/growth & development MH - *Cognition/physiology MH - Curriculum PMC - PMC13273906 OTO - NOTNLM OT - ABCD OT - ABCD-ReproNim OT - Hackathon OT - ReproNim OT - Research educational course COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/11 05:43 MHDA- 2026/08/11 23:35 PMCR- 2026/06/05 CRDT- 2026/06/10 18:04 PHST- 2025/12/01 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/08/11 23:35 [medline] PHST- 2026/06/11 05:43 [pubmed] PHST- 2026/06/10 18:04 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - S1878-9293(26)00092-7 [pii] AID - 101755 [pii] AID - 10.1016/j.dcn.2026.101755 [doi] PST - ppublish SO - Dev Cogn Neurosci. 2026 Aug;80:101755. doi: 10.1016/j.dcn.2026.101755. Epub 2026 Jun 5. PMID- 42269021 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260923 IS - 2369-1999 (Electronic) IS - 2369-1999 (Linking) VI - 12 DP - 2026 Jun 10 TI - Monitoring Steps and Heart Rate Using a Withings Smartwatch in Children and Adolescents With Cancer: Validation Study. PG - e77766 LID - 10.2196/77766 [doi] LID - e77766 AB - BACKGROUND: Consumer smartwatches offer potential for continuous monitoring of physical activity during childhood cancer treatment. However, their validity for measuring step count and heart rate in this population has not been established. OBJECTIVE: This study examined the validity of a Withings smartwatch for monitoring step count and heart rate in children and adolescents undergoing cancer treatment. METHODS: Children and adolescents aged 8 to 18 years under active cancer treatment wore a Withings smartwatch for 12 weeks. For validation purposes, children and adolescents simultaneously wore an ActiGraph wGT3X-BT accelerometer for 1 week under free-living conditions to assess step count agreement and were connected to a clinical heart rate monitor under resting conditions to assess heart rate agreement. Linear mixed models with participant ID as a random effect were used to estimate mean differences and derive 95% limits of agreement for repeated measurements. RESULTS: A total of 14 children and adolescents participated in each of the validation analyses. The smartwatch recorded significantly fewer steps than the ActiGraph accelerometer for both steps per hour (mean difference 174 steps per hour; 95% limits of agreement=-283 to 633; P<.001) and steps per day (mean difference 3154 steps per day; 95% limits of agreement=-394 to 6702; P<.001), with increasing discrepancy at higher activity levels, suggesting proportional bias. No statistically significant difference in heart rate was observed between the smartwatch and the clinical heart rate monitor under resting conditions (mean difference -1.07 beats per minute; 95% limits of agreement=-17.55 to 15.41; P=.24). CONCLUSIONS: In children and adolescents undergoing cancer treatment, the Withings smartwatch showed minimal systematic bias for resting heart rate assessment, although individual variability was considerable. In contrast, step counts demonstrated systematic underestimation and wide limits of agreement compared with a research-grade accelerometer. The use of smartwatch-derived step counts for clinical benchmarking or goal setting in this population cannot currently be recommended. CI - (c)Emma den Hartog, Marta Fiocco, Patrick van der Torre, Wim J E Tissing, Emma J Verwaaijen. Originally published in JMIR Cancer (https://cancer.jmir.org). FAU - den Hartog, Emma AU - den Hartog E AUID- ORCID: 0009-0005-6373-2625 AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. FAU - Fiocco, Marta AU - Fiocco M AUID- ORCID: 0000-0001-5588-0277 AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. AD - Mathematical Institute, Leiden University, Leiden, The Netherlands. FAU - van der Torre, Patrick AU - van der Torre P AUID- ORCID: 0000-0001-9697-2418 AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. FAU - Tissing, Wim J E AU - Tissing WJE AUID- ORCID: 0000-0001-9101-507X AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. AD - Department of Pediatric Oncology and Hematology, University of Groningen, Beatrix Children's Hospital, Groningen, The Netherlands. FAU - Verwaaijen, Emma J AU - Verwaaijen EJ AUID- ORCID: 0000-0003-1350-3363 AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. LA - eng PT - Journal Article PT - Validation Study DEP - 20260610 PL - Canada TA - JMIR Cancer JT - JMIR cancer JID - 101666844 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Heart Rate/physiology MH - Female MH - Male MH - *Neoplasms/physiopathology/therapy MH - *Exercise/physiology MH - Accelerometry/instrumentation/methods MH - Reproducibility of Results PMC - PMC13252708 OTO - NOTNLM OT - heart rate OT - pediatric oncology OT - smartwatch OT - steps OT - validity COIS- Conflicts of Interest: None declared. EDAT- 2026/06/11 05:39 MHDA- 2026/06/12 13:01 PMCR- 2026/06/10 CRDT- 2026/06/10 14:43 PHST- 2025/05/19 00:00 [received] PHST- 2026/03/10 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/06/12 13:01 [medline] PHST- 2026/06/11 05:39 [pubmed] PHST- 2026/06/10 14:43 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - v12i1e77766 [pii] AID - 77766 [pii] AID - 10.2196/77766 [doi] PST - epublish SO - JMIR Cancer. 2026 Jun 10;12:e77766. doi: 10.2196/77766. PMID- 42268871 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Geospatial variation and machine learning approaches to predict open defecation practice in Zambia. PG - e0350923 LID - 10.1371/journal.pone.0350923 [doi] LID - e0350923 AB - BACKGROUND: Open defecation is the disposal of human feces in fields, bushes, forests, open waterways, beaches, and other open areas. It worsens the environment, contaminates drinking water sources, causes malnutrition and low school attendance in children, and aids in the spread of diseases like cholera, diarrhea, dysentery, typhoid, polio, and hepatitis A. The purpose of this study was geospatial variation and machine learning approaches to predict open defecation in Zambia. METHODS: This study used secondary data analysis from the cross-sectional Zambia Demographic and Health Survey (ZMDHS) 2024. Spatial distribution, spatial autocorrelation, incremental autocorrelation, spatial interpolation, and hot spot area detection were all examined using ArcGIS 10.7. Python was used to identify the features of open defecation practice using machine-learning algorithms. We carried out an 80/20% data split, one-hot data encoding, data transformation and integration, data cleaning, and 10-fold stratified cross-validation. This study employed seven machine-learning algorithms, including adaptive boosting, cat boosting, random forest, light boosting, extreme gradient boosting, decision tree and logistic regression. RESULTS: Among 12,808 households in Zambia, 12.1% were practiced open defecation. Spatial analysis revealed significant clustering, with hot spots concentrated in Southern, Western and Eastern regions, highlighting areas in urgent need of intervention. Machine learning models were applied to predict open defecation practices, with light gradient boost performing the best model with AUC of 83.83%. From this study, 198 true positives were generated by the model for the classification of open defecation practice, accurately identifying those who reported engaging in this behavior. CONCLUSION: Wealth index, access to treated water, access to electricity, educational level, and age of household head, access to media, and region were the most significant features of open defecation practice. Governments, NGOs, policy makers, and researchers can use these data to create targeted interventions for improving health and environmental sanitation based on the gaps and disparities discovered. CI - Copyright: (c) 2026 Birlie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Birlie, Andualem Addisu AU - Birlie AA AUID- ORCID: 0009-0000-2337-0192 AD - Department of Health Informatics, College of Medicine and Health Science, Samara University, Samara, Ethiopia. FAU - Meshesha, Nega Abebe AU - Meshesha NA AD - Department of Public Health, Institute of Health, Dambi Dollo University, Dambi Dollo, Ethiopia. FAU - Tizie, Sefefe Birhanu AU - Tizie SB AD - Department of Health Informatics, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia. FAU - Wondie, Smegnew Gichew AU - Wondie SG AD - Department of Public Health, College of Medicine and Health Science, Mizan Tepi University, Mizan Aman, Ethiopia. FAU - Teshome, Selamawit Gashaw AU - Teshome SG AD - School of Public Health, Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia. FAU - Bedada, Tesfaye Deribe AU - Bedada TD AUID- ORCID: 0009-0003-7102-5790 AD - Department of Health Informatics, School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. FAU - Muluneh, Ayana Alebachew AU - Muluneh AA AD - Department of Health Informatics, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia. FAU - Eticha, Biruktawit Lelisa AU - Eticha BL AD - Department of Health Informatics, School of Public Health, College of Medicine and Health Science, Wachemo University, Hossana, Ethiopia. FAU - Dube, Geleta Nenko AU - Dube GN AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. FAU - Wodessa, Gelgelo AU - Wodessa G AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. FAU - Mengistie, Muluken Belachew AU - Mengistie MB AUID- ORCID: 0000-0002-0606-9477 AD - Department of Health Informatics, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Zambia MH - Humans MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - Random Forest MH - *Defecation MH - Predictive Learning Models MH - Cross-Sectional Studies MH - Classification Algorithms MH - Prediction Algorithms MH - Spatial Analysis PMC - PMC13252813 COIS- The authors declare that there are no competing interests. EDAT- 2026/06/11 05:39 MHDA- 2026/06/15 11:31 PMCR- 2026/06/10 CRDT- 2026/06/10 13:43 PHST- 2026/03/05 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/15 11:31 [medline] PHST- 2026/06/11 05:39 [pubmed] PHST- 2026/06/10 13:43 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - PONE-D-26-11222 [pii] AID - 10.1371/journal.pone.0350923 [doi] PST - epublish SO - PLoS One. 2026 Jun 10;21(6):e0350923. doi: 10.1371/journal.pone.0350923. eCollection 2026. PMID- 42268692 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260624 IS - 1938-2359 (Electronic) IS - 0090-4481 (Linking) VI - 55 IP - 6 DP - 2026 Jun TI - Risks and Benefits of Social Media on Adolescent Health. PG - e222-e228 LID - 10.3928/19382359-20260223-02 [doi] AB - Adolescents increasingly construct aspects of their identity and form relationships by interacting on social media; yet, clinical frameworks lag behind technological change. This review synthesizes recent evidence on how platform design, usage patterns, and individual differences influence both benefits and harms. Problematic use is associated with sleep disturbance, mood and attention disorders, body image concerns, cyberbul-lying, and exposure to self-harm content, with disproportionate burdens for female patients and youth who are marginalized. Meanwhile, online communities can foster connection, coping, and help seeking, particularly for adolescents facing stigma or isolation. We propose a structured, developmentally informed workflow incorporating brief screening, targeted use of validated tools, and collaborative family media planning. Rather than centering total screen time, we emphasize function-focused, harm-reduction approaches to harness digital platforms as a tool for adolescent health. FAU - Sellars, Suzanna E AU - Sellars SE AD - Department of Pediatrics, Craig Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia, Pennsylvania. FAU - Kabra, Rashi AU - Kabra R AD - Department of Pediatrics, Craig Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia, Pennsylvania. LA - eng PT - Journal Article PT - Review DEP - 20260601 PL - United States TA - Pediatr Ann JT - Pediatric annals JID - 0356657 SB - IM MH - Adolescent MH - Humans MH - *Adolescent Behavior/psychology MH - *Adolescent Health MH - *Digital Media MH - *Media Exposure MH - *Social Media COIS- Disclosure: SES has received support for attending meetings and travel from Children's Hospital of Philadelphia (CHOP) GME (Graduate Medical Education) and Leadership and Education in Adolescent Health Program at CHOP. RK has received support for attending meetings and travel from CHOP. EDAT- 2026/06/11 05:39 MHDA- 2026/06/13 00:40 CRDT- 2026/06/10 12:04 PHST- 2026/06/13 00:40 [medline] PHST- 2026/06/11 05:39 [pubmed] PHST- 2026/06/10 12:04 [entrez] AID - 10.3928/19382359-20260223-02 [doi] PST - ppublish SO - Pediatr Ann. 2026 Jun;55(6):e222-e228. doi: 10.3928/19382359-20260223-02. Epub 2026 Jun 1. PMID- 42268165 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261005 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 10 DP - 2026 Oct TI - Development and Application of the Paced Bottle-Feeding Checklist. PG - 997-1004 LID - S1499-4046(26)00105-3 [pii] LID - 10.1016/j.jneb.2026.04.012 [doi] AB - OBJECTIVE: Characterize the paced bottle-feeding (PBF) Checklist, evaluate its preliminary reliability and validity, and examine associations between PBF adherence, feeding practices, and sociodemographic characteristics. METHODS: Interrater reliability of the coding scheme was assessed using intraclass correlations from a secondary analysis of data from a within-subject experimental study of mother-infant feeding interactions. General linear models determined associations between PBF and key variables. RESULTS: Coders achieved good interrater reliability (intraclass correlation = 0.81). Paced bottle-feeding scores significantly higher during the PBF condition than in the typical bottle-feeding condition (P = 0.01). Scores associated with family income (P = 0.009) and federal assistance program participation (P < 0.001), with higher scores for mothers with higher income and those not participating in federal assistance programs. CONCLUSIONS AND IMPLICATIONS: The checklist is a practical tool for clinical use, enabling tailored education for bottle-feeding families. Future research can explore its impact on infant growth trajectories and expand its use to other caregivers. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Richardson, Taylor N AU - Richardson TN AD - College of Nursing, East Carolina University, Greenville, NC. Electronic address: nelsonta22@ecu.edu. FAU - Kay, Melissa C AU - Kay MC AD - Department of Pediatrics and Epidemiology and Prevention, School of Medicine, Wake Forest University, Winston-Salem, NC. FAU - Ventura, Alison K AU - Ventura AK AD - Department of Kinesiology and Public Health and Center for Health Research, California Polytechnic State University, San Luis Obispo, CA. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - *Bottle Feeding/methods/statistics & numerical data MH - *Checklist/methods MH - Infant MH - Female MH - Reproducibility of Results MH - Mother-Child Relations MH - Adult MH - Mothers OTO - NOTNLM OT - bottle feeding OT - feeding behavior OT - infant food OT - parent-child relations COIS- Conflict of Interest Disclosure The authors have not stated any conflicts of interest. EDAT- 2026/06/10 11:43 MHDA- 2026/10/05 23:29 CRDT- 2026/06/10 10:29 PHST- 2025/01/17 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/04/19 00:00 [accepted] PHST- 2026/10/05 23:29 [medline] PHST- 2026/06/10 11:43 [pubmed] PHST- 2026/06/10 10:29 [entrez] AID - S1499-4046(26)00105-3 [pii] AID - 10.1016/j.jneb.2026.04.012 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Oct;58(10):997-1004. doi: 10.1016/j.jneb.2026.04.012. Epub 2026 Jun 10. PMID- 42267872 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2639-8028 (Electronic) IS - 2639-8028 (Linking) VI - 8 IP - 6 DP - 2026 Jun 1 TI - Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance. PG - e1411 LID - 10.1097/CCE.0000000000001411 [doi] LID - e1411 AB - OBJECTIVE: Although efforts have been made to standardize fluid balance calculations in the ICU, there is a limited understanding of how different calculation methods relate to one another across an ICU admission. We quantified the agreement between the cumulative fluid balance calculated from fluid intake and output (CFBf) and cumulative fluid balance calculated from serial weights (CFBw) in critically ill children during the first week of ICU admission. DESIGN: Retrospective, multicenter, federated observational study. SETTING: Four pediatric medical-SICUs (PICU) and two pediatric cardiac ICUs (PCICU) from four tertiary care centers. PATIENTS: Analysis included 8,895 pediatric patients (younger than 19 yr) representing 12,388 ICU encounters from 2023 to 2024. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A patient's anchor weight was the weight closest to ICU admission. CFBf and CFBw were calculated at the time of new weight measurements. We assessed agreement between CFBf and CFBw using Bland-Altman analyses, stratified by ICU day and patient subgroups (neonates, early anchor weights [weight on ICU day 0], and encounters with unmeasured urine occurrences). Across all units and subgroups, CFBf exceeded CFBw (mean difference: all patients = 4.7 %CFB, early anchor weight = 4.7 %CFB, neonates = 5.9 %CFB). The mean difference increased significantly over time (days 0-3: 2.7% vs. days 4-7: 8.1%, p < 0.05), with greater divergence in neonates and those with early anchor weights. CONCLUSIONS: CFBf consistently exceeded CFBw across all subgroups, with a greater divergence on ICU days 4-7. Clinicians should understand these differences, prioritizing early and frequent patient weights throughout ICU admission. Future studies should assess each method's association with patient outcomes to identify the most clinically informative CFB method. CI - Copyright (c) 2026 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. FAU - Shinnick, Finley J AU - Shinnick FJ AD - Department of Pediatrics, Golisano Children's Hospital, University of Rochester School of Medicine, Rochester, NY. FAU - Hasson, Denise C AU - Hasson DC AD - Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, New York, NY. FAU - Kothari, Ulka AU - Kothari U AD - Department of Pediatrics, NYU Long Island School of Medicine, Mineola, NY. FAU - Shah, Ami AU - Shah A AD - Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, New York, NY. FAU - Odum, James D AU - Odum JD AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. FAU - Braun, Chloe G AU - Braun CG AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY. FAU - Dixon, Celeste G AU - Dixon CG AD - Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. FAU - Fitzgerald, Julie C AU - Fitzgerald JC AD - Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. FAU - Martin, Susan D AU - Martin SD AD - Department of Pediatrics, Golisano Children's Hospital, University of Rochester School of Medicine, Rochester, NY. FAU - Terry, Nina AU - Terry N AD - Department of Pediatrics, Golisano Children's Hospital, University of Rochester School of Medicine, Rochester, NY. FAU - Dziorny, Adam C AU - Dziorny AC AUID- ORCID: 0000-0002-3392-2795 AD - Department of Pediatrics, Golisano Children's Hospital, University of Rochester School of Medicine, Rochester, NY. CN - Evidence-Driven Evaluation and Management of fluid Accumulation (EDEMA) Collaborative LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260610 PL - United States TA - Crit Care Explor JT - Critical care explorations JID - 101746347 SB - IM UOF - medRxiv. 2025 Nov 04:2025.10.22.25338544. doi: 10.1101/2025.10.22.25338544. PMID: 41282779 MH - Humans MH - *Water-Electrolyte Balance/physiology MH - Retrospective Studies MH - Critical Illness/therapy MH - Infant MH - Intensive Care Units, Pediatric MH - Male MH - Female MH - Child MH - *Body Weight/physiology MH - Child, Preschool MH - Infant, Newborn PMC - PMC13252996 OTO - NOTNLM OT - cumulative fluid balance OT - fluid balance assessment OT - fluid overload OT - pediatric intensive care unit COIS- The authors have disclosed that they do not have any potential conflicts of interest. FIR - Barbera, Andrew IR - Barbera A IRAD- (University of Alabama Birmingham, Birmingham, AL). FIR - Clifford, Rebecca IR - Clifford R IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Dapul, Heda M IR - Dapul HM IRAD- (NYU Langone Health, New York, NY). FIR - Fitts, Brittany IR - Fitts B IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Gettelfinger, Jacquelyn IR - Gettelfinger J IRAD- (Norton Healthcare, Louisville, KY). FIR - Grey, Erin IR - Grey E IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Hopwood, Andrew IR - Hopwood A IRAD- (UNC School of Medicine, Chapel Hill, NC). FIR - Kavanaugh, Taylor IR - Kavanaugh T IRAD- (University of Louisville, Louisville, KY). FIR - Lapira, Jenna IR - Lapira J IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Levenbrown, Yosef IR - Levenbrown Y IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Martinez, Michael IR - Martinez M IRAD- (NYU Langone Health, New York, NY). FIR - Weiss, Scott IR - Weiss S IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Weyback, Caroline IR - Weyback C IRAD- (NYU Langone Health, New York, NY). FIR - Williams, Allison IR - Williams A IRAD- (University of Alabama Birmingham, Birmingham, AL). EDAT- 2026/06/10 11:44 MHDA- 2026/06/13 00:38 PMCR- 2026/06/10 CRDT- 2026/06/10 09:33 PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/10 11:44 [pubmed] PHST- 2026/06/10 09:33 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 02107256-202606000-00015 [pii] AID - CCE-D-26-00047 [pii] AID - 10.1097/CCE.0000000000001411 [doi] PST - epublish SO - Crit Care Explor. 2026 Jun 10;8(6):e1411. doi: 10.1097/CCE.0000000000001411. eCollection 2026 Jun 1. PMID- 42267217 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260610 LR - 20260813 IS - 2071-9736 (Electronic) IS - 1025-9848 (Print) IS - 1025-9848 (Linking) VI - 31 DP - 2026 TI - Prevalence of overweight, obesity and central adiposity among grade seven adolescents in urban Tshwane, South Africa. PG - 3328 LID - 10.4102/hsag.v31i0.3328 [doi] LID - 3328 AB - BACKGROUND: The global increase in overweight and obesity among adolescents is a significant public health priority, especially in low- and middle-income countries. In South Africa, urbanisation and lifestyle changes have exacerbated this challenge, but there is a lack of disaggregated data available to inform effective local responses. AIM: To assess and describe the prevalence of overweight, obesity and central adiposity in Grade seven adolescents in urban Tshwane, South Africa, and explore its association with socioeconomic characteristics. SETTING: The study was conducted in five diverse fee-paying public primary schools in urban Tshwane, Gauteng province. METHODS: A quantitative, descriptive cross-sectional design recruited 164 adolescents aged 11-14 years. Anthropometric measures were performed according to World Health Organization (WHO) standards. These included a survey of height and weight to derive body mass index (BMI-for-age) z-scores, as well as waist circumference to height ratio (WHtR). Socioeconomic status was assessed using the validated Family Affluence Scale. Data analysis included descriptive statistics and chi-square tests to determine the association between categorical variables. RESULTS: The combined prevalence of overweight and obesity was 23.7%, with a greater burden among girls (36.4% of 12 year olds) compared to boys (16.7%). The risk of central adiposity (WHtR >/= 0.5) was found in 25% of participants, with 7.3% at very high risk. Household income was significantly associated with obesity (p = 0.043), while parental education was not statistically significant. CONCLUSION: The high prevalence of excess adiposity, particularly among female adolescents, indicates an emerging cardiometabolic risk profile among the group. CONTRIBUTION: This study addresses a critical gap in South African public health literature by providing locally specific, disaggregated data on the nutritional status of urban adolescents in Tshwane, a cohort that is underrepresented in contrast to conventional rural or national surveys. CI - (c) 2026. The Authors. FAU - Mokose, Nonie M AU - Mokose NM AUID- ORCID: 0009-0009-8300-0869 AD - Department of Sustainable Food Systems and Development, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Swanepoel, Jan W AU - Swanepoel JW AUID- ORCID: 0000-0002-0812-2657 AD - Department of Sustainable Food Systems and Development, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Oldewage-Theron, Wilna AU - Oldewage-Theron W AUID- ORCID: 0000-0001-8975-5693 AD - Department of Sustainable Food Systems and Development, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa. LA - eng PT - Journal Article DEP - 20260526 PL - South Africa TA - Health SA JT - Health SA = SA Gesondheid JID - 101213385 PMC - PMC13243840 OTO - NOTNLM OT - South Africa OT - Urban health OT - adolescent obesity OT - central adiposity OT - overweight OT - socioeconomic status COIS- The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article. EDAT- 2026/06/10 06:52 MHDA- 2026/06/10 06:53 PMCR- 2026/05/26 CRDT- 2026/06/10 04:45 PHST- 2025/11/11 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/10 06:53 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/10 04:45 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - HSAG-31-3328 [pii] AID - 10.4102/hsag.v31i0.3328 [doi] PST - epublish SO - Health SA. 2026 May 26;31:3328. doi: 10.4102/hsag.v31i0.3328. eCollection 2026. PMID- 42266680 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study. PG - 1814097 LID - 10.3389/fimmu.2026.1814097 [doi] LID - 1814097 AB - INTRODUCTION: Many patients report adverse symptoms following wheat/gluten consumption. As "Self-Reported Wheat/Gluten Sensitivity" lacks gold-standard biomarkers, characterizing biological profiles in Western populations is essential for precision management. This study analyzes immunogenetic (HLA-DQ) and serological (IgG) patterns in a real-world clinical cohort. METHODS: A retrospective observational study used Real-World Evidence (RWE) from 100 symptomatic individuals (2019-2024) selected via non-probabilistic convenience sampling. Participants underwent HLA-DQ genotyping and serum IgG reactivity testing for wheat/gluten via a validated ELISA-based assay. Data normality was formally assessed using the Shapiro-Wilk test, revealing a non-parametric distribution (W=0.59, p<0.001). Consequently, inferential analyses included Chi-square (X (2)) tests for categorical associations, Spearman's rank correlation (r(s) ), and Odds Ratio (OR) calculations with 95% Confidence Intervals (95% CI). RESULTS: A 100% cumulative frequency of HLA-DQ susceptibility variants was observed. The immunogenetic landscape revealed complex heterozygosity: DQ1 was most prevalent (56%), followed by DQ2 (54%), DQ3 (40%), and DQ8 (33%). DQ8 (X(2) = 10.24; p=0.001) and DQ3 (X(2) = 4.84; p=0.028) were significant markers. Specific IgG reactivity occurred in 68% of cases, showing strong wheat-gluten correlation (r(s)=0.887; p<0.001) and extraordinary cross-reactivity (OR=88.2; 95% CI: 25.8-301.4; p<0.001). DISCUSSION: Findings reveal a ubiquitous HLA-DQ frequency, suggesting a consistent genetic background in symptomatic individuals that significantly exceeds prevalence in the general Western population. This enriched 'mosaic' may facilitate immune activation. Furthermore, the observed IgG cross-reactivity validates the 'wheat/gluten complex' as a synchronized immunological unit, supporting a transition toward biomarker-informed nutrition in real-world settings. CI - Copyright (c) 2026 White, Verzura, White, Rodriguez, White and Garcia Bravo. FAU - White, Andreina AU - White A AD - Universidad Central de Venezuela (UCV), Caracas, Venezuela. AD - Autonomous University of Barcelona, Barcelona, Spain. AD - University of Barcelona, Barcelona, Spain. AD - NutriWhite Headquarters, Madrid, Spain. FAU - Verzura, Julie AU - Verzura J AD - Universidad de Carabobo (UC), Valencia, Venezuela. AD - Venezuelan Institute for Scientific Research (IVIC), Caracas, Venezuela. AD - National Association of Nutritional Professionals, Berkeley, CA, United States. FAU - White, Mariana AU - White M AD - NutriWhite - International Organization of Immune Nutrition Specialists, Pompano Beach, FL, United States. AD - Universidad Simon Bolivar (USB), Caracas, Venezuela. FAU - Rodriguez, Carol AU - Rodriguez C AD - NutriWhite Headquarters, Caracas, Venezuela. AD - Regis College, Weston, MA, United States. FAU - White, Mercedes AU - White M AD - Department of Assistance and Nutrition, School of Nutrition and Dietetics, Faculty of Medicine, University of Los Andes (ULA), Merida, Venezuela. FAU - Garcia Bravo, Milaidi AU - Garcia Bravo M AD - Department of Assistance and Nutrition, School of Nutrition and Dietetics, Faculty of Medicine, University of Los Andes (ULA), Merida, Venezuela. LA - eng PT - Journal Article PT - Observational Study DEP - 20260525 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (HLA-DQ Antigens) RN - 0 (Immunoglobulin G) RN - 8002-80-0 (Glutens) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *HLA-DQ Antigens/genetics/immunology MH - Female MH - *Immunoglobulin G/blood/immunology MH - Retrospective Studies MH - Male MH - Adult MH - Middle Aged MH - *Wheat Hypersensitivity/immunology/genetics/blood/diagnosis MH - *Glutens/immunology MH - Genetic Predisposition to Disease MH - Triticum/immunology MH - Genotype MH - Biomarkers/blood MH - *Celiac Disease/immunology/genetics/blood MH - Young Adult MH - Adolescent PMC - PMC13243097 OTO - NOTNLM OT - HLA-DQ antigens OT - cross-reactions OT - genetic predisposition to disease OT - immunoglobulin G OT - innate immunity OT - precision medicine OT - real world evidence OT - wheat hypersensitivity COIS- MaW, MeW, and JV are employed by nutriWhite immunonutrition clinic. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/10 06:53 MHDA- 2026/06/15 11:31 PMCR- 2026/05/25 CRDT- 2026/06/10 04:39 PHST- 2026/02/19 00:00 [received] PHST- 2026/03/28 00:00 [revised] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/06/15 11:31 [medline] PHST- 2026/06/10 06:53 [pubmed] PHST- 2026/06/10 04:39 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1814097 [doi] PST - epublish SO - Front Immunol. 2026 May 25;17:1814097. doi: 10.3389/fimmu.2026.1814097. eCollection 2026. PMID- 42266546 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260610 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Association between the albumin-to-lymphocyte ratio and short-term mortality in critically Ill pediatric patients: a retrospective cohort study and machine learning analysis. PG - 1795057 LID - 10.3389/fped.2026.1795057 [doi] LID - 1795057 AB - BACKGROUND: Albumin-to-lymphocyte ratio (ALR), integrating nutritional status and immune-inflammatory response, has been proposed as a potential prognostic biomarker in various clinical settings. However, evidence regarding its prognostic value in critically ill pediatric patients remains limited. This study aimed to investigate the association between early ALR and short-term all-cause mortality in pediatric intensive care unit (PICU) patients and to evaluate its predictive utility. METHODS: Clinical data were extracted from a large single-center PICU database including critically ill children admitted between 2010 and 2019. Patients were stratified into tertiles according to ALR measured within the first 24 hours after PICU admission. The primary outcome was 28-day all-cause mortality. Cox proportional hazards models were applied to assess the association between ALR and mortality after adjusting for potential confounders. Restricted cubic spline analyses were conducted to explore potential non-linear relationships. Kaplan-Meier survival curves were used to compare survival across ALR groups. Subgroup analyses were performed to evaluate the robustness of the association. In addition, multiple machine learning models incorporating ALR and other clinical variables were developed to predict 28-day mortality, and model performance was assessed using the area under the receiver operating characteristic curve (AUC). RESULTS: A total of 7,591 critically ill children were included, with an overall 28-day mortality rate of 4.53%. Across ALR tertiles, the intermediate group showed the lowest observed 28-day mortality and the highest survival probability. In the fully adjusted Cox model, both the intermediate and highest tertiles were associated with lower mortality risk than the lowest tertile, with the strongest association observed in the intermediate tertile (T2: HR 0.55, 95% CI 0.42-0.74; T3: HR 0.65, 95% CI 0.49-0.86). Restricted cubic spline analysis revealed a significant non-linear association between ALR and mortality, characterized by a rapid decline in risk at low ALR levels, a nadir in the intermediate range, and a slight increase at higher ALR levels. This pattern was consistent with the Kaplan-Meier analysis, which showed the highest survival probability in the middle ALR tertile. Subgroup analyses showed consistent associations across different clinical strata. Among the machine learning models, the XGBoost model achieved the best discriminative performance, with an AUC of 0.835. In the SHAP-based interpretation, ALR contributed to model prediction and ranked tenth among the selected features. CONCLUSION: As a simple, readily available, and cost-effective biomarker derived from routine laboratory tests, ALR may serve as a complementary tool for early risk stratification and prognostic assessment in the PICU setting. CI - (c) 2026 Chen, Tang, Ye, Chen and Liu. FAU - Chen, Kai AU - Chen K AD - Department of Pediatrics, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China. FAU - Tang, Huiyan AU - Tang H AD - Department of Pediatrics, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China. FAU - Ye, Yuanyuan AU - Ye Y AD - Department of Pediatrics, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China. FAU - Chen, Jie AU - Chen J AD - Department of Biology, Jiaxing Construction Industry School, Jiaxing, Zhejiang, China. FAU - Liu, Jie AU - Liu J AD - Department of Critical Care Medicine, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260525 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13243273 OTO - NOTNLM OT - albumin-to-lymphocyte ratio OT - machine learning OT - mortality OT - pediatric intensive care unit OT - risk stratification COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/10 06:52 MHDA- 2026/06/10 06:53 PMCR- 2026/05/25 CRDT- 2026/06/10 04:37 PHST- 2026/01/24 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/06/10 06:53 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/10 04:37 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1795057 [doi] PST - epublish SO - Front Pediatr. 2026 May 25;14:1795057. doi: 10.3389/fped.2026.1795057. eCollection 2026. PMID- 42266133 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1399-3046 (Electronic) IS - 1397-3142 (Linking) VI - 30 IP - 6 DP - 2026 Jun TI - Gut Microbiome-Immune Interactions During Pediatric Hematopoietic Cell Transplantation: From Conditioning to GvHD Prevention. PG - e70371 LID - 10.1111/petr.70371 [doi] AB - Hematopoietic stem cell transplantation (HCT) offers curative potential for children with high-risk hematologic malignancies. However, this treatment carries significant risks, particularly acute graft-versus-host disease (aGvHD), which affects 30%-60% of pediatric recipients and causes 15%-20% of post-transplant deaths. The gut microbiome has emerged as a critical factor in aGvHD development, yet pediatric microbiome dynamics differ substantially from adult patterns. This review seeks to evaluate the current state of knowledge of how the gut microbiome impacts aGvHD pathogenesis and the methods of microbiome modulation that may lead to aGvHD prevention and treatment. Children's microbiomes undergo more rapid compositional shifts and contain distinct bacterial compositions enriched in taxa like Bifidobacterium and Lactobacillus. During transplant, conditioning regimens and antibiotics cause dramatic microbiome disruption in children. This eliminates beneficial bacteria that normally maintain intestinal barrier integrity and produce immunomodulatory metabolites. Consequently, this disruption triggers inflammatory cascades through bacterial translocation, impaired immune education, and altered metabolite production. Unlike adults, where low diversity consistently predicts poor outcomes, pediatric studies show inconsistent diversity-outcome relationships, with only pre-transplant microbiome patterns reliably predicting aGvHD risk. Several promising interventions have emerged from this research. These include enteral nutrition to preserve beneficial bacteria, targeted antibiotic strategies, and fecal microbiota transplantation. Fecal microbiota transplantation has shown remarkable response rates in pediatric steroid-resistant aGvHD cases. Nevertheless, significant knowledge gaps remain regarding pediatric-specific mechanisms, optimal biomarkers, and age-appropriate therapeutic approaches for microbiome-directed aGvHD prevention. CI - (c) 2026 Wiley Periodicals LLC. FAU - Duggar, Marygrace AU - Duggar M AD - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Leardini, Davide AU - Leardini D AUID- ORCID: 0000-0002-4673-5876 AD - Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. AD - Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, Italy. FAU - Muratore, Edoardo AU - Muratore E AD - Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. FAU - Margolis, Elisa B AU - Margolis EB AUID- ORCID: 0000-0001-6217-0564 AD - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA. FAU - Masetti, Riccardo AU - Masetti R AD - Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. AD - Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, Italy. LA - eng PT - Journal Article PT - Review PL - Denmark TA - Pediatr Transplant JT - Pediatric transplantation JID - 9802574 RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation/adverse effects MH - Child MH - *Graft vs Host Disease/prevention & control/immunology/microbiology MH - *Gastrointestinal Microbiome/immunology MH - *Transplantation Conditioning/methods MH - Fecal Microbiota Transplantation MH - Anti-Bacterial Agents/therapeutic use OTO - NOTNLM OT - antibiotic resistance OT - biotherapeutics OT - gut microbiota OT - hematopoietic stem cell transplant EDAT- 2026/06/10 06:52 MHDA- 2026/06/12 18:42 CRDT- 2026/06/10 04:03 PHST- 2026/05/06 00:00 [revised] PHST- 2026/03/03 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/12 18:42 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/10 04:03 [entrez] AID - 10.1111/petr.70371 [doi] PST - ppublish SO - Pediatr Transplant. 2026 Jun;30(6):e70371. doi: 10.1111/petr.70371. PMID- 42265933 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260903 IS - 1600-0412 (Electronic) IS - 0001-6349 (Print) IS - 0001-6349 (Linking) VI - 105 IP - 9 DP - 2026 Sep TI - Population-specific validation of fetal weight formulas: Evidence from a multicenter near-delivery cohort. PG - 1680-1688 LID - 10.1111/aogs.70278 [doi] AB - INTRODUCTION: Accurate ultrasound estimated fetal weight (EFW) supports key perinatal decisions. This study aimed to compare the accuracy of a population-specific formula with that of a widely used global model in pregnancies examined near delivery. MATERIAL AND METHODS: This was a secondary analysis of a prospective Japanese cohort study to develop a new fetal ultrasound biometry reference chart. Fetal ultrasound measurements were obtained by Japan Society of Ultrasonics in Medicine-certified sonographers or under their supervision and submitted to the coordinating center, where EFW was calculated using the Shinozuka and Hadlock-3 formulas. Analyses were restricted to cases with EFW available from both formulas. The primary analysis included examinations within 7 days before delivery; a sensitivity analysis restricted the interval to /= 2 mL.kg(-)(1).d(-)(1)), limiting early drain removal or selective omission under close monitoring. This study aimed to develop and validate an intuitive preoperative nomogram using readily available clinical indicators (e.g., cyst diameter, age) to predict high-drainage risk after robot-assisted RYHJ and support individualized drainage management. METHODS: This single-center retrospective cohort study enrolled 129 children with CDC who underwent da Vinci robot-assisted RYHJ. Based on weight-adjusted daily drain output, patients were divided into low-drainage (< 2 mL.kg(-)(1).d(-)(1), n = 30) and high-drainage (>/= 2 mL.kg(-)(1).d(-)(1), n = 99) groups. Potential predictors were identified via univariate and multivariate logistic regression and incorporated into a nomogram. Model performance was assessed using the area under the receiver operating characteristic curve (AUC) and calibration plots. RESULTS: Multivariate analysis identified younger age as an independent predictor of high drainage output (OR = 0.983, 95% CI: 0.972-0.994), and larger cyst diameter as a potential predictor showing a trend toward association (OR = 1.321, 95% CI: 0.979-1.783). The final nomogram, incorporating cyst diameter, age, body mass index (BMI), hemoglobin (HGB), and globulin (GLB), showed good discrimination (AUC = 0.753) and calibration. The optimal risk threshold was 79.88%, yielding a specificity of 75.9%, and, using an optimal threshold, identifies low-risk patients suitable for early drain removal protocols to guide individualized drainage management. CONCLUSION: We have developed and validated a nomogram model based on "cyst diameter + age" (supplemented by BMI, HGB, and GLB) that enables noninvasive, precise assessment of high-drainage risk following robot-assisted RYHJ. Notably, the model identifies a low-risk subset-older children with smaller cysts-for whom early drain removal (e.g., within 24-48 h) is safe, and in whom selective drain omission could be prospectively evaluated under rigorous monitoring. This risk-stratified approach has the potential to reduce drain-related complications and optimize ERAS pathways following robot-assisted RYHJ. As this is an internal validation only, external validation in independent cohorts is warranted before clinical implementation. CI - (c) 2026. The Author(s). FAU - Zhang, Jing AU - Zhang J AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - You, Tao AU - You T AD - Medical Department, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, 430070, China. FAU - Qin, Xinke AU - Qin X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Liang, Chong AU - Liang C AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Zhu, Zhenchuang AU - Zhu Z AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Liu, Xin AU - Liu X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Ji, Siqi AU - Ji S AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - He, Xiaoqiong AU - He X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Duan, Xufei AU - Duan X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Yan, Xueqiang AU - Yan X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. yanxueqiang1@163.com. LA - eng GR - 2025FEYJS005/the Laboratory of Hepatobiliary and Pancreatic Diseases in Children/ PT - Journal Article PT - Validation Study DEP - 20260610 PL - England TA - BMC Surg JT - BMC surgery JID - 100968567 SB - IM MH - Humans MH - *Nomograms MH - *Choledochal Cyst/surgery/pathology MH - Retrospective Studies MH - *Drainage MH - Infant MH - Female MH - *Anastomosis, Roux-en-Y/methods MH - Male MH - Child, Preschool MH - Child MH - *Robotic Surgical Procedures MH - *Postoperative Complications/etiology MH - *Jejunostomy/methods MH - Age Factors PMC - PMC13474786 OTO - NOTNLM OT - Choledochal cyst (CDC) OT - Enhanced recovery after surgery (ERAS) OT - High drainage output OT - Nomogram OT - Pediatric surgery OT - Robot-assisted Roux-en-Y hepaticojejunostomy (RYHJ) COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Wuhan Children's Hospital of Huazhong University of Science and Technology (Approval No. 2024R030-E01). Owing to the retrospective design of the study, the need for informed consent was waived. Owing to the retrospective design of the study, the need for informed consent was waived by the ethics committee of Wuhan Children's Hospital of Huazhong University of Science and Technology. The study was conducted according to the principles of the Declaration of Helsinki. Consent for publication: Not Applicable. This is a retrospective study. Competing interests: The authors declare no competing interests. EDAT- 2026/06/10 06:54 MHDA- 2026/08/14 05:38 PMCR- 2026/06/10 CRDT- 2026/06/10 00:10 PHST- 2025/11/17 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/14 05:38 [medline] PHST- 2026/06/10 06:54 [pubmed] PHST- 2026/06/10 00:10 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s12893-026-03912-1 [pii] AID - 3912 [pii] AID - 10.1186/s12893-026-03912-1 [doi] PST - epublish SO - BMC Surg. 2026 Jun 10;26(1):543. doi: 10.1186/s12893-026-03912-1. PMID- 42264886 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1541-3144 (Electronic) IS - 0194-2638 (Linking) VI - 46 IP - 6 DP - 2026 TI - Functional Exercise Performance in Children with Cerebral Palsy: Is the 1-Minute Sit-to-Stand Test an Alternative to the 6-Minute Walk Test? PG - 1390-1405 LID - 10.1080/01942638.2026.2682292 [doi] AB - OBJECTIVES: This study examined the validity, test-retest reliability, and clinical feasibility of the 1-minute sit-to-stand test (1MSTS) as a practical alternative to the 6-minute walk test (6MWT) for assessing functional exercise capacity in children with cerebral palsy (CP). METHODS: Seventy-eight children aged 5-18 years with spastic hemiplegic CP (Gross Motor Function Classification System I-II) completed the 1MSTS and 6MWT in random order on the same day. Test-retest reliability of the 1MSTS was evaluated using the intraclass correlation coefficient (ICC), standard error of measurement (SEM), and minimal detectable change (MDC). Construct validity was assessed using correlation and linear regression analyses. RESULTS: The 1MSTS demonstrated good test-retest reliability (ICC = 0.78), with an SEM of 1.49 repetitions and an MDC(95) of 4.12 repetitions. A very strong association was observed between 1MSTS and 6MWT performances (rho = 0.886, p < .001). Linear regression analysis further demonstrated that 6MWT distance explained approximately 80% of the variance in 1MSTS repetitions (R(2) = 0.799). These findings indicate that the 1MSTS captures functional exercise capacity assessed by the 6MWT. CONCLUSION: The 1MSTS is a valid, reliable, and clinically feasible alternative to the 6MWT for evaluating functional exercise capacity in children with spastic hemiplegic CP. TRIAL REGISTRATION: ClinicalTrials.gov (NCT07136129). FAU - Ergun, Betul AU - Ergun B AUID- ORCID: 0000-0001-7212-2937 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Firat University, Elazig, Turkey. FAU - Baykan Copuroglu, Ozge AU - Baykan Copuroglu O AUID- ORCID: 0000-0003-1014-8845 AD - Incesu Ayse ve Saffet Arslan Health Services Vocational School, Kayseri University, Kayseri, Turkey. FAU - Baykan, Muge AU - Baykan M AUID- ORCID: 0000-0002-8299-6926 AD - Recep Tayyip Erdogan University Training and Research Hospital, Rize, Turkey. FAU - Gurer, Feyza AU - Gurer F AUID- ORCID: 0000-0002-8539-607X AD - Department of Health Management, Faculty of Health Sciences, Yuksek Ihtisas University, Ankara, Turkey. FAU - Abakay, Hanife AU - Abakay H AUID- ORCID: 0000-0003-4047-7965 AD - Physiotherapy Program, Incesu Ayse ve Saffet Arslan Health Services Vocational School, Kayseri University, Kayseri, Turkey. LA - eng SI - ClinicalTrials.gov/NCT07136129 PT - Journal Article DEP - 20260609 PL - England TA - Phys Occup Ther Pediatr JT - Physical & occupational therapy in pediatrics JID - 8109120 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Child MH - Female MH - Male MH - Reproducibility of Results MH - Adolescent MH - Child, Preschool MH - *Exercise Test/methods MH - Walk Test MH - Feasibility Studies MH - *Exercise Tolerance/physiology OTO - NOTNLM OT - Cerebral palsy OT - functional exercise capacity OT - sit-to-stand test OT - test-retest reliability EDAT- 2026/06/10 06:52 MHDA- 2026/10/27 05:29 CRDT- 2026/06/09 21:04 PHST- 2026/10/27 05:29 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/09 21:04 [entrez] AID - 10.1080/01942638.2026.2682292 [doi] PST - ppublish SO - Phys Occup Ther Pediatr. 2026;46(6):1390-1405. doi: 10.1080/01942638.2026.2682292. Epub 2026 Jun 9. PMID- 42264869 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1558-0776 (Electronic) IS - 1071-9091 (Linking) VI - 58 DP - 2026 Jul TI - Age-appropriate assessment of concussion in children and adolescents. PG - 101267 LID - S1071-9091(26)00011-2 [pii] LID - 10.1016/j.spen.2026.101267 [doi] AB - Sport-related concussion (SRC) in children and adolescents presents unique diagnostic challenges due to heterogeneous clinical presentations and rapid neurodevelopmental trajectories. This focused review emphasizes that diagnosis fundamentally relies on symptomatic reporting and objective physiological assessments spanning multiple domains, integrating age-specific tools such as the revised Sport Concussion Assessment Tool 6 (SCAT6) and the Sport Concussion Office Assessment Tool 6 (SCOAT6). While the SCAT6 (ages >13) and Child SCAT6 (ages 8-12) are optimized for acute evaluation within the initial 72 hours, the SCOAT6 framework facilitates comprehensive multidomain assessment during the subacute phase (3-30 days). Clinicians must prioritize visio-vestibular and oculomotor screenings, as dysfunction in these areas is highly prevalent and associated with protracted recovery. For younger children (ages 5-9), the specialized VOMS-Child (VOMS-C) uses developmentally appropriate binary symptom reporting to accurately identify injury. Management paradigms have shifted toward active rehabilitation; the cornerstone of modern care is Sub-Symptom Threshold Aerobic Exercise (STTAE), which, when initiated within 2-10 days post-injury, significantly accelerates recovery. While computerized neurocognitive testing and emerging biomarkers offer insights, clinical decision-making must remain anchored in validated functional assessments while accounting for suboptimal effort in youth populations. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Beletanga, Maria AU - Beletanga M AD - Universidad Internacional del Ecuador, Quito, Ecuador. Electronic address: lola.beletanga@gmail.com. FAU - Vaca, Andrea AU - Vaca A AD - Universidad Internacional del Ecuador, Quito, Ecuador. FAU - Mohanty, Mugdha AU - Mohanty M AD - University of Massachusetts (UMASS), Worcester, MA, USA. FAU - Garrido, Gabriel AU - Garrido G AD - Universidad de las Americas (UDLA), Quito, Ecuador. FAU - Lopez, Dennis AU - Lopez D AD - Hospital Metropolitano, Quito, Ecuador. FAU - Roman, Marcelo AU - Roman M AD - Hospital Metropolitano, Quito, Ecuador. FAU - Torres, Alcy R AU - Torres AR AD - Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260322 PL - United States TA - Semin Pediatr Neurol JT - Seminars in pediatric neurology JID - 9441351 SB - IM MH - Humans MH - Child MH - *Brain Concussion/diagnosis MH - Adolescent MH - *Athletic Injuries/diagnosis MH - Age Factors OTO - NOTNLM OT - Adolescent OT - Brain concussion OT - Child OT - Exercise OT - Pediatric neurology OT - Rehabilitation OT - SCAT6 OT - SCOAT6 OT - Sport-related concussion OT - Vestibular/Ocular Motor Screening (VOMS) COIS- Declaration of competing interest There are no personal, professional, or financial affiliations with sports organizations that could bias the clinical recommendations presented in this manuscript. EDAT- 2026/06/10 06:54 MHDA- 2026/06/13 00:38 CRDT- 2026/06/09 21:04 PHST- 2026/02/07 00:00 [received] PHST- 2026/03/21 00:00 [revised] PHST- 2026/03/21 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/10 06:54 [pubmed] PHST- 2026/06/09 21:04 [entrez] AID - S1071-9091(26)00011-2 [pii] AID - 10.1016/j.spen.2026.101267 [doi] PST - ppublish SO - Semin Pediatr Neurol. 2026 Jul;58:101267. doi: 10.1016/j.spen.2026.101267. Epub 2026 Mar 22. PMID- 42264793 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1532-9283 (Electronic) IS - 1360-8592 (Linking) VI - 47 DP - 2026 Jul TI - Kinetic-functional assessment of the adolescent idiopathic scoliosis: a cohort study. PG - 199-204 LID - S1360-8592(26)00051-3 [pii] LID - 10.1016/j.jbmt.2026.03.036 [doi] AB - INTRODUCTION: It is estimated that 1 to 3% of the world's population is diagnosed with idiopathic scoliosis, with a higher prevalence in females and a higher index of curves in the right thoracic region. Diagnosis and clinical follow-up are based on radiographic analysis and measurement of the Cobb angle, which is considered the gold standard for classifying scoliotic severity. OBJECTIVE: This study investigated the applicability and feasibility of the kinetic-functional examination in patients with adolescent idiopathic scoliosis, considering the main functional tests described in the literature. METHODS: It was a cross-sectional, quantitative cohort study (CAAE xxxxxxxxxxxxxxxxx) involving individuals of both sexes, aged between 10 and 14 years, who had a diagnosis of idiopathic scoliosis of the adolescent confirmed by radiographic examination (Cobb angle between 10 degrees and 50 degrees ). Statistical significance was set p < 0.05. RESULTS: A total of 157 individuals participated in the study, 77.7% were female and 57.9% were considered underweight according to body mass index. Regarding the degree of severity of the curve, 61.8% of the adolescents had a moderate scoliotic curve. A trend towards a reduction in spine flexibility was observed as the severity of the curvature increased, especially in mild and moderate curves, while the strength tests showed negative values, with no marked differences between the severity groups. CONCLUSION: The standardized application of functional tests ensures reliability and reproducibility of the results, and ensures the patient's performance, reducing biases, favoring clinical validity and assisting in the accurate identification of functional deficits. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Silva, Darlan Gonzaga da AU - Silva DGD AD - State University of Bahia (UNEB), Salvador, BA, Brazil. Electronic address: darlagfisio@gmail.com. FAU - Nascimento, Lara Galvao AU - Nascimento LG AD - Scoliosis Rehabilitation Clinical Center, Bahia, BA, Brazil. Electronic address: laragalvao26@gmail.com. FAU - da Silva, Beatriz Cerqueira AU - da Silva BC AD - Scoliosis Rehabilitation Clinical Center, Bahia, BA, Brazil. Electronic address: beatrizcerqueira.fisio@gmail.com. FAU - Andrade, Rodrigo Mantelatto AU - Andrade RM AD - Scoliosis Rehabilitation Clinical Center, Sao Paulo, SP, Brazil. Electronic address: rodrigoandradefisioterapia@gmail.com. FAU - Paineiras-Domingos, Laisa Liane AU - Paineiras-Domingos LL AD - Postgraduate Program in Medicine and Health, Faculty of Medicine of Bahia, Federal University of Bahia (UFBA), Salvador, BA, Brazil. Electronic address: laisa.liane@ufba.br. FAU - Lessa, Paulo Itamar Ferraz AU - Lessa PIF AD - State University of Bahia (UNEB), Salvador, BA, Brazil; Scoliosis Rehabilitation Clinical Center, Bahia, BA, Brazil. Electronic address: plessa@uneb.br. LA - eng PT - Journal Article DEP - 20260401 PL - United States TA - J Bodyw Mov Ther JT - Journal of bodywork and movement therapies JID - 9700068 SB - IM MH - Humans MH - *Scoliosis/physiopathology/diagnosis MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Child MH - Male MH - Cohort Studies MH - Range of Motion, Articular/physiology MH - Severity of Illness Index MH - Muscle Strength/physiology MH - Spine/physiopathology MH - Body Mass Index OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Flexibility OT - Functional tests OT - Mobility OT - Muscle strength COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/10 06:52 MHDA- 2026/06/12 18:40 CRDT- 2026/06/09 21:02 PHST- 2026/02/24 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/12 18:40 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/09 21:02 [entrez] AID - S1360-8592(26)00051-3 [pii] AID - 10.1016/j.jbmt.2026.03.036 [doi] PST - ppublish SO - J Bodyw Mov Ther. 2026 Jul;47:199-204. doi: 10.1016/j.jbmt.2026.03.036. Epub 2026 Apr 1. PMID- 42263736 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260918 IS - 1938-2480 (Electronic) IS - 1538-8506 (Linking) VI - 39 IP - 12 DP - 2026 Oct TI - Comparison of Long-Term Tunnel Widening in Anterior Cruciate Ligament Reconstruction Using Allograft and Hamstring Autograft: More Than 10 Years' Mean Follow-Up. PG - 654-661 LID - 10.1055/a-2886-8283 [doi] AB - Bone tunnel widening following anterior cruciate ligament reconstruction (ACLR) is a well-recognized radiological phenomenon with multifactorial etiology. While concerns have been raised regarding potentially greater tunnel enlargement with allografts due to immune-mediated responses, evidence remains inconsistent. This study compared long-term femoral and tibial tunnel widening between hamstring autograft and allograft reconstruction at a mean follow-up exceeding 10 years. A retrospective analysis was conducted on 60 patients who underwent primary ACLR between 2011 and 2016 by a single surgeon. Group I consisted of 29 patients receiving soft tissue allografts (Achilles, tibialis anterior, or peroneus longus tendons), while Group II included 31 patients with four-strand hamstring autografts. All procedures utilized identical fixation: adjustable-loop suspension device (femur) and bioabsorbable interference screw with tibial staple. Patients with previous knee surgery, re-rupture, clinical graft failure, concomitant ligament procedures, or significant chondral lesions were excluded. Computed tomography scans at final follow-up (mean: 10.7 years) were analyzed using standardized oblique reformatted sections perpendicular to tunnel axes. Six measurements per tunnel (three levels x two planes) were averaged. Tunnel widening was expressed as absolute change (Deltamm) and percentage relative to intraoperative drill bit diameter. Two blinded orthopedic surgeons performed independent measurements. Statistical analysis included Mann-Whitney U test, analysis of covariance adjusted for body mass index (BMI) and follow-up duration, categorical threshold analysis, and correlation analysis with Bonferroni correction. No significant differences were observed between groups for tibial widening (allograft 2.07 +/- 1.75 mm vs. autograft 2.31 +/- 1.72 mm, p = 0.500) or femoral widening (1.73 +/- 1.48 mm vs. 2.30 +/- 1.63 mm, p = 0.157). After adjustment for BMI and follow-up duration, between-group differences remained nonsignificant (all adjusted p > 0.0125 after Bonferroni correction). Categorical distribution across predefined thresholds showed similar patterns. Initial tunnel diameter inversely correlated with tibial percentage widening (r =-0.373, p = 0.003). Interobserver reliability was excellent (intraclass correlation coefficient: 0.89-0.92). At long-term follow-up, allograft and hamstring autograft demonstrated comparable tunnel widening patterns, suggesting graft selection should prioritize clinical factors beyond tunnel enlargement concerns. CI - Thieme. All rights reserved. FAU - Ipek, Enver AU - Ipek E AUID- ORCID: 0000-0001-6205-1207 AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Altuntas, Yusuf AU - Altuntas Y AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Balkanli, Bahadir AU - Balkanli B AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Yuksel, Mehmet Alp AU - Yuksel MA AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Akbas, Harun AU - Akbas H AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Eren, Osman Tugrul AU - Eren OT AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260609 PL - Germany TA - J Knee Surg JT - The journal of knee surgery JID - 101137599 SB - IM MH - Humans MH - Retrospective Studies MH - *Anterior Cruciate Ligament Reconstruction/methods MH - Female MH - Follow-Up Studies MH - *Hamstring Tendons/transplantation MH - Adult MH - Allografts MH - Male MH - Autografts MH - *Tibia/surgery/diagnostic imaging MH - Transplantation, Autologous MH - *Femur/surgery/diagnostic imaging MH - *Anterior Cruciate Ligament Injuries/surgery MH - Young Adult MH - Tomography, X-Ray Computed MH - Transplantation, Homologous MH - Adolescent COIS- The authors declare that they have no conflict of interest. EDAT- 2026/06/10 06:52 MHDA- 2026/09/18 23:36 CRDT- 2026/06/09 19:03 PHST- 2026/09/18 23:36 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/09 19:03 [entrez] AID - 10.1055/a-2886-8283 [doi] PST - ppublish SO - J Knee Surg. 2026 Oct;39(12):654-661. doi: 10.1055/a-2886-8283. Epub 2026 Jun 9. PMID- 42261973 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260821 IS - 2153-2176 (Electronic) IS - 2153-2168 (Print) IS - 2153-2168 (Linking) VI - 22 IP - 4 DP - 2026 Jun TI - Family-Based Behavioral Treatment for Childhood Obesity Adapted to Align with the MOHealthNet Medicaid Benefit: Results of the Missouri Childhood Obesity Research Demonstration Study. PG - 211-222 LID - 10.1177/21532176261450310 [doi] AB - BACKGROUND: This study leveraged a novel Missouri Medicaid (MOHealthNet) benefit to adapt and implement evidence-based family-based behavioral treatment (FBT) within health care settings in alignment with policy requirements. METHODS: In a nonrandomized matched-comparison trial, 108 parent-child dyads participated in FBT, and 92 dyads attended at least one session. Licensed Clinical Social Workers or Registered Dietitian Nutritionists offered 26-33 FBT hours delivered virtually over 6-12 months to Medicaid-insured patients in an urban and rural pediatric health system in Missouri. The matched-comparison group included 186 participants. The Reach, Effectiveness, Adoption, Implementation, and Maintenance framework (RE-AIM) framework was used to evaluate effectiveness (primary) and reach (secondary) and explore adoption, implementation, and maintenance. RESULTS: Children in the FBT group reduced their percent over median body mass index (BMI) compared with the matched comparison group (mean reduction: -3.9 +/- 1.4, d = -0.42). Within the FBT group, participants also demonstrated improvements in coping with teasing, health-related quality of life, and family health habits (all p < 0.05). Families rated the program as highly acceptable. Reach data indicated enrolled patients had similar BMI, sex, and ethnic backgrounds compared with eligible but non-enrolled patients (ps > 0.301). CONCLUSIONS: Data demonstrate the feasibility of adopting and implementing FBT within health care systems and inform efforts to support maintenance. FBT reached a diverse population of families receiving Medicaid in pediatric primary care settings and was associated with greater improvements in youth weight outcomes compared with a matched comparison group. Adaptations made to align with the benefit may have reduced the magnitude of effects; however, this policy provides an opportunity to deliver FBT within primary care settings and expand access. FAU - Dreyer Gillette, Meredith L AU - Dreyer Gillette ML AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Kansas City, University of Missouri Kansas City, Kansas City, MO, USA. FAU - Button, Alyssa M AU - Button AM AD - Children's Hospital of Richmond, Healthy Lifestyles Center, Virginia Commonwealth University, Richmond, VA, USA. FAU - Staiano, Amanda E AU - Staiano AE AD - Department of Population and Public Health Sciences, Pennington Biomedical Research Center, Baton Rouge, LA, USA. FAU - Nelson, Lisa C AU - Nelson LC AD - Freeman Health System, Joplin, MO, USA. FAU - Carlson, Jordan A AU - Carlson JA AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Children's Mercy Kansas City, University of Missouri Kansas City, Kansas City, MO, USA. FAU - Dean, Kelsey M AU - Dean KM AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Kansas City, Kansas City, MO, USA. FAU - Bullard, Sarah E AU - Bullard SE AD - Children's Mercy Kansas City, Kansas City, MO, USA. FAU - Monocello, Lawrence T AU - Monocello LT AD - Department of Anthropology, Texas A&M University, College Station, TX, USA. FAU - Beyl, Robbie AU - Beyl R AD - Pennington Biomedical Research Center, Baton Rouge, LA, USA. FAU - Welch, R Robinson AU - Welch RR AD - Washington University in St. Louis, St. Louis, MO, USA. FAU - Hampl, Sarah E AU - Hampl SE AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Kansas City, University of Missouri Kansas City, Kansas City, MO, USA. FAU - Wilfley, Denise E AU - Wilfley DE AUID- ORCID: 0000-0002-3599-8689 AD - Washington University in St. Louis, St. Louis, MO, USA. CN - MO CORD Research Group LA - eng GR - T32 HL130357/HL/NHLBI NIH HHS/United States GR - U18 DP006425/DP/NCCDPHP CDC HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States GR - UL1 TR002345/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260609 PL - United States TA - Child Obes JT - Childhood obesity (Print) JID - 101542497 SB - IM MH - Humans MH - *Medicaid MH - Female MH - Male MH - Missouri/epidemiology MH - United States MH - Child MH - *Pediatric Obesity/therapy/psychology MH - *Behavior Therapy/methods MH - *Family Therapy/methods MH - Adolescent PMC - PMC13372312 MID - NIHMS2178626 OTO - NOTNLM OT - Medicaid OT - adoption OT - behavioral health OT - family-based treatment OT - obesity treatment OT - reach COIS- Author Disclosure StatementNo competing financial interests exist. EDAT- 2026/06/09 12:49 MHDA- 2026/06/25 06:37 PMCR- 2026/07/15 CRDT- 2026/06/09 08:03 PHST- 2026/06/25 06:37 [medline] PHST- 2026/06/09 12:49 [pubmed] PHST- 2026/06/09 08:03 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1177/21532176261450310 [doi] PST - ppublish SO - Child Obes. 2026 Jun;22(4):211-222. doi: 10.1177/21532176261450310. Epub 2026 Jun 9. PMID- 42261970 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260817 IS - 1939-3229 (Electronic) IS - 1939-3210 (Linking) VI - 19 IP - 3 DP - 2026 Sep TI - Heavy metals and preservatives in commercial yoghurt from northern Iraq. PG - 251-261 LID - 10.1080/19393210.2026.2679459 [doi] AB - Pb and Cd occurrence, as well as sodium benzoate, potassium sorbate and nitrate concentrations, were investigated in 75 commercially available yogurts from the Kurdistan region of Iraq. Validated ICP-MS and HPLC-UV methods revealed good linearity (R(2) > 0.995), satisfactory recoveries (90-108%) and appropriate limits of detection. Pb and Cd levels were below maximum limits as established by the European Commission and the Codex Alimentarius. Detection of preservatives in plain yoghurt was not interpreted as straightforward regulatory compliance, as it may indicate unauthorized additive use, carry-over, or product-category/labelling inconsistency. Exposure assessment indicated low non-carcinogenic risk for adults. However, children showed higher relative exposure due to lower body weight, with only the HI value for children in the Sulaymaniyah region marginally exceeding 1. These findings highlight the importance of continuous monitoring and refined evaluation of cumulative dietary exposure. It also provides baseline data for regional food safety assessment and risk management. FAU - Qader, Muzhda Qasim AU - Qader MQ AUID- ORCID: 0000-0002-3561-7137 AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Othman, Ahmed Jamal AU - Othman AJ AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Rahman, Basoz Tariq AU - Rahman BT AUID- ORCID: 0009-0009-9472-3923 AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Mohamad, Soma M AU - Mohamad SM AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Haini, Clara Samad AU - Haini CS AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Fatah, Kaiwan Kareemkhan AU - Fatah KK AD - Department of Earth Science and Petroleum, College of Science, Salahaddin University, Erbil, Iraq. LA - eng PT - Journal Article DEP - 20260609 PL - England TA - Food Addit Contam Part B Surveill JT - Food additives & contaminants. Part B, Surveillance JID - 101317183 RN - 0 (Metals, Heavy) RN - 0 (Food Preservatives) RN - X045WJ989B (Sorbic Acid) RN - OJ245FE5EU (Sodium Benzoate) SB - IM MH - *Yogurt/analysis/economics MH - *Food Contamination/analysis MH - Humans MH - Iraq MH - *Metals, Heavy/analysis MH - *Food Preservatives/analysis MH - Chromatography, High Pressure Liquid MH - Limit of Detection MH - Sorbic Acid/analysis MH - Sodium Benzoate/analysis MH - Reproducibility of Results OTO - NOTNLM OT - Yoghurt OT - estimated daily intake OT - food safety OT - health risk OT - heavy metals OT - preservatives EDAT- 2026/06/09 12:49 MHDA- 2026/08/17 23:39 CRDT- 2026/06/09 08:03 PHST- 2026/08/17 23:39 [medline] PHST- 2026/06/09 12:49 [pubmed] PHST- 2026/06/09 08:03 [entrez] AID - 10.1080/19393210.2026.2679459 [doi] PST - ppublish SO - Food Addit Contam Part B Surveill. 2026 Sep;19(3):251-261. doi: 10.1080/19393210.2026.2679459. Epub 2026 Jun 9. PMID- 42261265 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260909 IS - 1944-7922 (Electronic) IS - 1060-3271 (Linking) VI - 109 IP - 5 DP - 2026 Sep 1 TI - Analysis of Taurine in Infant Formula and Adult Nutritionals by HILIC-MS/MS, Collaborative Study, AOAC Official Method 2022.03:2026, Final Action. PG - 828-832 LID - 10.1093/jaoacint/qsag049 [doi] AB - BACKGROUND: Taurine is recognized as an essential growth factor and as being critical in the maintenance of functional tissue regulation. The fortification of taurine to infant formulas is necessary to provide sufficient nutrient to maintain serum levels equivalent to those of their counterparts fed on their mother's milk. OBJECTIVE: To evaluate method reproducibility of AOAC First Action Official MethodSM 2022.03 for compliance with the performance requirements described in AOAC Standard Method Performance Requirements (SMPR(R)) 2014.013. METHODS: Following protein precipitation with Carrez solutions, taurine is extracted and analyzed by hydrophilic interaction liquid chromatography-tandem mass spectrometry using multiple reaction monitoring. Stable isotope-labeled taurine internal standard is used for quantification to correct for losses in extraction and variations in ionization in the ion source. RESULTS: Thirteen laboratories participated in the analysis of blind-duplicate samples of seven nutritional products. After outliers were removed, precision as reproducibility was found to be within limits set in SMPR 2014.013 (/= 1 cardiovascular risk factor and 39% had >/= 2 risk factors. CONCLUSIONS: One in four early CCS lives with food insecurity. These children concurrently experience multiple cardiovascular risk factors and suboptimal dietary quality. Interventions targeting food and nutrition insecurity and other modifiable cardiovascular risk factors have potential to mitigate late effects and advance equity in survivorship outcomes. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Aziz-Bose, Rahela AU - Aziz-Bose R AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. rahela_aziz-bose@dfci.harvard.edu. AD - Harvard Medical School, Boston, MA, USA. rahela_aziz-bose@dfci.harvard.edu. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. rahela_aziz-bose@dfci.harvard.edu. FAU - Paul, Morgan A AU - Paul MA AD - Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. FAU - Lokko, Lucille AU - Lokko L AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. FAU - Jones, Emily AU - Jones E AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. FAU - Meng, Julie AU - Meng J AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. FAU - Fry, Callie AU - Fry C AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. FAU - Kelly, Colleen A AU - Kelly CA AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. FAU - Umaretiya, Puja J AU - Umaretiya PJ AD - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Duhaney, Leanne AU - Duhaney L AD - Division of Cardiology, Boston Children's Hospital, Boston, MA, USA. FAU - Kenney, Lisa B AU - Kenney LB AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. FAU - Zhang, Fang Fang AU - Zhang FF AD - Friedman School of Nutrition and Public Policy, Tufts University, Boston, MA, USA. FAU - Bona, Kira AU - Bona K AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. LA - eng GR - T32 CA136432/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260609 PL - Germany TA - Support Care Cancer JT - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JID - 9302957 SB - IM MH - Humans MH - *Food Insecurity MH - Male MH - Female MH - Child MH - Heart Disease Risk Factors MH - *Cancer Survivors/statistics & numerical data MH - *Diet/standards/statistics & numerical data MH - *Cardiovascular Diseases/epidemiology/etiology MH - Child, Preschool MH - *Neoplasms/therapy MH - Infant MH - Cohort Studies MH - Adolescent MH - Risk Factors MH - Prevalence PMC - PMC13384394 MID - NIHMS2190528 OTO - NOTNLM OT - Cardiovascular disease OT - Childhood cancer survivors OT - Food insecurity OT - Nutrition insecurity OT - Social determinants of health COIS- Declarations. Ethics Approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Review Board of Dana-Farber Cancer Institute (protocol DFCI 23-398). Consent to participate: Informed consent was obtained from all study participants, with a waiver of written documentation of informed consent. Consent to publish: N/A Role of the Funder: The funders did not play a role in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; or the decision to submit the manuscript for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/06/09 00:34 MHDA- 2026/06/13 06:39 PMCR- 2027/06/09 CRDT- 2026/06/08 23:33 PHST- 2026/03/27 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/13 06:39 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 23:33 [entrez] PHST- 2027/06/09 00:00 [pmc-release] AID - 10.1007/s00520-026-10870-0 [pii] AID - 10.1007/s00520-026-10870-0 [doi] PST - epublish SO - Support Care Cancer. 2026 Jun 9;34(7):631. doi: 10.1007/s00520-026-10870-0. PMID- 42259585 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260624 IS - 1756-1833 (Electronic) IS - 0959-8138 (Linking) VI - 393 DP - 2026 Jun 8 TI - Advances in the management of ADHD in children and adolescents. PG - e082507 LID - 10.1136/bmj-2024-082507 [doi] AB - This review synthesizes evidence on managing attention deficit/hyperactivity disorder (ADHD) in children and adolescents, focusing on studies published between 2019 and 2025. Recent research supports a dimensional, pleiotropic model of ADHD characterized by heterogeneity, developmental fluctuation, and frequent comorbidity. ADHD is a chronic, fluctuating condition, underscoring the need for sustained and individualized care. Diagnostic strategies favor semi-structured interviews over rating scales, with neuroimaging or biological tests offering limited diagnostic utility. Neuropsychological testing situates symptoms within broader cognitive developmental profiles. Psychosocial interventions-particularly behavioral parent training, school focused interventions, and cognitive behavioral therapy-produce small but meaningful improvements in functioning, with outcomes strongly shaped by rater, expectancy, and context. Lifestyle interventions targeting physical activity and sleep show modest adjunctive benefits. Cognitive training does not generalize beyond trained tasks, and effects on neurofeedback are predominantly non-specific and contextual. Digital tools are expanding, but few are rigorously validated. Pharmacological treatment remains central, with stimulants showing robust short term efficacy and non-stimulants providing effective second line options. Advances in titration strategies, formulation design, and pharmacogenetics support movement towards precision oriented and personalized prescribing. Overall, the evidence supports a multimodal, pragmatic approach to care aligned with current international guidelines. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. FAU - Robaey, Philippe AU - Robaey P AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada probaey@cheo.on.ca. AD - Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada. FAU - Rogers, Maria A AU - Rogers MA AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Department of Psychology, Carleton University, Ottawa, ON, Canada. FAU - Schachar, Russell J AU - Schachar RJ AD - Department of Psychiatry, University of Toronto, Toronto, ON, Canada. AD - Department of Psychiatry, The Hospital for Sick Children, Toronto, ON, Canada. LA - eng PT - Journal Article PT - Review DEP - 20260608 PL - England TA - BMJ JT - BMJ (Clinical research ed.) JID - 8900488 RN - 0 (Central Nervous System Stimulants) SB - IM MH - Adolescent MH - Child MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/diagnosis/therapy MH - Central Nervous System Stimulants/therapeutic use MH - Cognitive Behavioral Therapy/methods MH - Cognitive Training COIS- Competing interests: We have read and understood the BMJ policy on declaration of interests and declare the following interests: none. EDAT- 2026/06/09 00:34 MHDA- 2026/06/10 06:53 CRDT- 2026/06/08 20:52 PHST- 2026/06/10 06:53 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 20:52 [entrez] AID - 10.1136/bmj-2024-082507 [doi] PST - epublish SO - BMJ. 2026 Jun 8;393:e082507. doi: 10.1136/bmj-2024-082507. PMID- 42259554 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260926 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 8 TI - Latent profiles of movement behaviour compositions and their associations with adiposity and health-related quality of life in Australian children: a cross-sectional and 12-month longitudinal study. PG - e109130 LID - 10.1136/bmjopen-2025-109130 [doi] LID - e109130 AB - OBJECTIVES: To identify profiles of compositional movement behaviour patterns among children and examine cross-sectional and 12-month associations with adiposity markers and health-related quality of life (HRQoL). DESIGN: Secondary analysis of data from the TransformUs cluster randomised controlled trial with cross-sectional and 12-month follow-up analyses. SETTING: Primary schools in metropolitan and regional areas of Victoria, Australia. PARTICIPANTS: Children aged 7-11 years with valid accelerometer at baseline, regardless of demographic, adiposity and HRQoL data available (n=792), were included in the analytical sample for the latent profile analysis. MEASURES: Sedentary time, light-intensity physical activity (LPA) and moderate- to vigorous-intensity physical activity (MVPA) along with their respective mean bout lengths were derived from raw acceleration data. Latent profile analysis used these measures (total times, as isometric log ratios and mean bout lengths) as input variables to classify distinct profiles for us as a categorical exposure variable in regression models. Primary outcomes were age- and sex-standardised body mass index, waist circumference and parent-reported HRQoL at baseline. Secondary outcomes were the same measures assessed at 12-month follow-up. RESULTS: Four distinct profiles were identified. The high MVPA-short sedentary bout profile (n=184) was characterised by the highest levels of MVPA, moderate sedentary time and the shortest mean sedentary bout duration. The low sedentary-high LPA profile (n=54) had the lowest sedentary time, the highest LPA and the longest mean LPA bout duration. Two profiles were characterised by high sedentary time: the high sedentary-long sedentary bout profile (n=149), which had the longest mean sedentary bout durations, and the high sedentary-shorter bouts profile (n=405), which also had high sedentary time but shorter bout durations for all intensities. While the omnibus Wald test for differences across profiles indicated uncertainty in the overall profile effect, the high MVPA-short sedentary bout profile had favourable adiposity levels cross-sectionally compared with the high sedentary-long sedentary bout reference profile in pairwise comparisons. No longitudinal associations were detected. CONCLUSIONS: Four distinct movement profiles were identified. Few pairwise differences between health outcomes were observed. While MVPA remains a key factor for promoting healthy body weight, our findings suggest that a variety of movement patterns - including those characterised by lower sedentary time and higher LPA - may also support health in children. TRIAL REGISTRATION: This study is a secondary analysis of the TransformUs effectiveness-implementation trial, registered with the Australian Clinical Trials Registry (ACTRN12617000204347; 1 April 2017). CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Verswijveren, Simone Jjm AU - Verswijveren SJ AUID- ORCID: 0000-0002-7709-7416 AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia s.verswijveren@deakin.edu.au. FAU - Miatke, Aaron AU - Miatke A AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Adelaide University, Adelaide, South Australia, Australia. AD - Centre for Adolescent Health, Murdoch children's Research Institute, Parkville, Victoria, Australia. FAU - Hesketh, Kylie D AU - Hesketh KD AUID- ORCID: 0000-0002-2702-7110 AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Ridgers, Nicola D AU - Ridgers ND AUID- ORCID: 0000-0001-5713-3515 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Adelaide University, Adelaide, South Australia, Australia. FAU - Contardo Ayala, Ana Maria AU - Contardo Ayala AM AUID- ORCID: 0000-0002-6192-0033 AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Dumuid, Dorothea AU - Dumuid D AUID- ORCID: 0000-0003-3057-0963 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Adelaide University, Adelaide, South Australia, Australia. AD - Murdoch children's Research Institute, Parkville, Victoria, Australia. FAU - Timperio, Anna AU - Timperio A AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Lund Rasmussen, Charlotte AU - Lund Rasmussen C AD - Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia. FAU - Stanford, Ty E AU - Stanford TE AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Adelaide University, Adelaide, South Australia, Australia. FAU - Gusi, Narcis AU - Gusi N AD - Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. FAU - Salmon, Jo AU - Salmon J AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. LA - eng PT - Journal Article DEP - 20260608 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Female MH - *Adiposity MH - Male MH - *Sedentary Behavior MH - Longitudinal Studies MH - *Quality of Life MH - *Exercise MH - Body Mass Index MH - Victoria MH - Accelerometry MH - Waist Circumference PMC - PMC13250231 OTO - NOTNLM OT - Child OT - EPIDEMIOLOGY OT - PUBLIC HEALTH EDAT- 2026/06/09 00:33 MHDA- 2026/06/12 18:41 PMCR- 2026/06/08 CRDT- 2026/06/08 20:42 PHST- 2026/06/12 18:41 [medline] PHST- 2026/06/09 00:33 [pubmed] PHST- 2026/06/08 20:42 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - bmjopen-2025-109130 [pii] AID - 10.1136/bmjopen-2025-109130 [doi] PST - epublish SO - BMJ Open. 2026 Jun 8;16(6):e109130. doi: 10.1136/bmjopen-2025-109130. PMID- 42259520 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 17 IP - 3 DP - 2026 Jun TI - Diagnostic Utility of Muscle Ultrasound for Sarcopenia in Prader-Willi Syndrome: A Cross-Sectional Study. PG - e70326 LID - 10.1002/jcsm.70326 [doi] LID - e70326 AB - BACKGROUND: Prader-Willi syndrome (PWS) is characterized by sarcopenic obesity; however, validated screening tools for muscle mass in clinical settings are lacking. This study aimed to evaluate the diagnostic utility of muscle ultrasound (US) for detecting low muscle mass in individuals with PWS. METHODS: This observational, cross-sectional study recruited 48 individuals with genetically confirmed PWS (International Classification of Diseases, 10th Revision Code Q87.1) from a specialized clinic (October 2022-June 2024). Appendicular skeletal muscle index (ASMI) via dual-energy x-ray absorptiometry (DXA) served as the primary outcome. Sarcopenia was defined based on Asian Working Group for Sarcopenia (AWGS) 2019 criteria. US predictors included muscle thickness (MT) of the rectus femoris (RF), vastus lateralis and gastrocnemius medialis (GM); pennation angle; and RF cross-sectional area (CSA). Analysis included Spearman's correlation (rho), multivariable linear regression (B) and receiver operating characteristic (ROC) curves. RESULTS: The cohort (n = 48; 47.9% women; median age 19.5 years, interquartile range [IQR] 12.3-26.8) had a 100% prevalence of obesity (median BMI 27.1 kg/m(2), IQR 22.2-31.4). All participants (100%) had a history of growth hormone treatment; 62.5% exhibited the deletion subtype. Low muscle mass was observed in 60.4% (n = 29), confirmed sarcopenia in 52.1% (n = 25) and severe sarcopenia (including low physical performance) in 20.8% (n = 10) participants. GM MT showed the strongest correlation with ASMI (rho = 0.689, p < 0.001, 95% confidence interval [CI] 0.50-0.81), followed by RF CSA (rho = 0.587, p < 0.001). Multivariable regression identified GM MT as a significant independent predictor of ASMI (B = 0.957, p = 0.011) after adjusting for BMI (B = 0.128, p < 0.001), age (B = 0.020, p = 0.044) and sex (B = -0.376, p = 0.029; R(2) = 0.67). ROC analysis for detecting low muscle mass yielded an area under the curve for GM MT of 0.759 (95% CI 0.616-0.901, p = 0.003), with an optimal cut-off of 1.69 cm (sensitivity 86.2%, specificity 63.2%). CONCLUSIONS: Sarcopenia affects 52.1% of patients with PWS, with 20.8% meeting criteria for severe sarcopenia. Ultrasound of the gastrocnemius medialis is a valid, radiation-free predictor of skeletal muscle mass and serves as a practical diagnostic tool for sarcopenic obesity in PWS. CI - (c) 2026 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Yu, Luo-Hua AU - Yu LH AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. FAU - Wu, Hsin-Chi AU - Wu HC AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. AD - Department of Medicine, Tzu Chi University, Hualien, Taiwan. FAU - Tzeng, I-Shiang AU - Tzeng IS AD - Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. FAU - Luo, Yan-Ting AU - Luo YT AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. FAU - Tsai, Li-Ping AU - Tsai LP AD - Department of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan. AD - Department of Molecular Biology and Human Genetics, College of Medicine, Tzu Chi University, Hualien, Taiwan. FAU - Chiu, Valeria AU - Chiu V AUID- ORCID: 0000-0002-5170-2964 AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. AD - Department of Medicine, Tzu Chi University, Hualien, Taiwan. LA - eng GR - TCRD-TPE-112-28/Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/ GR - TCRD-TPE-112-RT-5/Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/ PT - Journal Article PT - Observational Study PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Humans MH - *Prader-Willi Syndrome/complications MH - *Sarcopenia/etiology/diagnosis/diagnostic imaging MH - Female MH - Cross-Sectional Studies MH - Ultrasonography/methods MH - Male MH - *Muscle, Skeletal/diagnostic imaging MH - Adult MH - Adolescent MH - Young Adult MH - Child PMC - PMC13246224 OTO - NOTNLM OT - Prader-Willi syndrome OT - body composition OT - sarcopenia OT - ultrasonography COIS- The authors declare no conflicts of interest. EDAT- 2026/06/09 00:33 MHDA- 2026/06/12 04:10 PMCR- 2026/06/08 CRDT- 2026/06/08 20:13 PHST- 2026/05/02 00:00 [revised] PHST- 2024/06/20 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/12 04:10 [medline] PHST- 2026/06/09 00:33 [pubmed] PHST- 2026/06/08 20:13 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - JCSM70326 [pii] AID - 10.1002/jcsm.70326 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2026 Jun;17(3):e70326. doi: 10.1002/jcsm.70326. PMID- 42259208 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260724 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 268 DP - 2026 Aug TI - A study on the impact of AI health monitoring devices on exercise persistence among physical education students. PG - 107176 LID - S0001-6918(26)00977-7 [pii] LID - 10.1016/j.actpsy.2026.107176 [doi] AB - OBJECTIVE: This study investigates how the use motivations of AI health monitoring devices influence exercise persistence in physical education students, focusing on the mediating role of exercise enjoyment and exercise commitment. METHOD: The researchers conducted a survey among 764 Chinese university students using the Motivation for Use Scale, the Physical Activity Enjoyment Scale, the Exercise Commitment Scale, and the Physical Exercise Adherence Scale. The proposed chain mediation model was subsequently tested and validated. RESULTS: (1) The use motivations of AI health monitoring devices show a significant positive association with exercise persistence. (2) Exercise enjoyment and exercise commitment demonstrate both independent and sequential mediation effects in the model, with the mediation effect of exercise commitment being relatively stronger. CONCLUSION: The study identifies important associations among use motivations, exercise enjoyment, exercise commitment, and exercise persistence, offering useful insights for future practices and research aimed at supporting exercise-related behaviors among physical education students. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Wang, Chunxiao AU - Wang C AD - College of Sports Science and Health, Harbin Sport University, Harbin, Heilongjiang, 150008, China. FAU - Meng, Nijia AU - Meng N AD - College of Sports Science and Health, Harbin Sport University, Harbin, Heilongjiang, 150008, China. FAU - Han, Peng AU - Han P AD - College of Sports Science and Health, Harbin Sport University, Harbin, Heilongjiang, 150008, China. FAU - Liu, Chunhua AU - Liu C AD - Center of Training and Competition, Harbin Sport University, Harbin, Heilongjiang, 150008, China. Electronic address: hrbipe2019@163.com. LA - eng PT - Journal Article DEP - 20260608 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - Female MH - *Students/psychology MH - *Exercise/psychology MH - *Motivation MH - Male MH - *Physical Education and Training MH - Young Adult MH - Universities MH - Adult MH - Digital Health MH - Adolescent OTO - NOTNLM OT - Exercise commitment OT - Exercise enjoyment OT - Exercise persistence OT - Physical education students OT - The use motivations of AI health monitoring devices COIS- Declaration of competing interest The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2026/06/09 00:34 MHDA- 2026/07/24 06:35 CRDT- 2026/06/08 18:10 PHST- 2025/07/23 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/07/24 06:35 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 18:10 [entrez] AID - S0001-6918(26)00977-7 [pii] AID - 10.1016/j.actpsy.2026.107176 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Aug;268:107176. doi: 10.1016/j.actpsy.2026.107176. Epub 2026 Jun 8. PMID- 42259169 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 160 DP - 2026 Sep TI - Effect of a competency-based nurse-led exclusive breastfeeding training program on nurses' counseling competence and postpartum mothers' breastfeeding self-efficacy: A quasi-experimental study in Egypt. PG - 104890 LID - S0266-6138(26)00194-4 [pii] LID - 10.1016/j.midw.2026.104890 [doi] AB - BACKGROUND: Exclusive breastfeeding (EBF) is a highly cost-effective public health strategy that reduces infant morbidity and mortality and improves maternal health outcomes. However, EBF rates remain below global targets, particularly in low- and middle-income countries (LMICs). AIM: To evaluate the effect of a structured, competency-based nurse-led EBF training program on maternity nurses' breastfeeding knowledge and counseling competence and to examine its association with postpartum mothers' breastfeeding self-efficacy and exclusive breastfeeding outcomes. METHODS: A quasi-experimental pre-post intervention study was conducted in the postpartum wards of Benha University Hospitals, Egypt. Forty-three maternity nurses were assessed at baseline, immediately post-intervention, and at 3-month follow-up. Postpartum mothers (N = 162) were recruited in three phase-based repeated cross-sectional cohorts (n = 54 per phase). Nurse outcomes included breastfeeding knowledge and observed counseling competence. Maternal outcomes included breastfeeding self-efficacy measured using the Breastfeeding Self-Efficacy Scale-Short Form and exclusive breastfeeding status assessed at 6 months using WHO/UNICEF Infant and Young Child Feeding indicators. RESULTS: Nurses demonstrated significant improvements in breastfeeding knowledge and observed counseling competence immediately post-intervention (p < .001), with gains sustained at 3-month follow-up. Mothers who received counseling after the nurse-led EBF training program demonstrated greater improvements in breastfeeding self-efficacy and maintained exclusive breastfeeding for longer durations compared with mothers counseled during the pre-training phase. CONCLUSION: A structured competency-based nurse-led exclusive breastfeeding training program improved nurses' counseling competence and was associated with enhanced maternal breastfeeding self-efficacy and longer exclusive breastfeeding duration. Workforce-strengthening interventions may represent a feasible and scalable strategy to improve postpartum breastfeeding outcomes in LMIC hospital settings. CLINICAL TRIAL NUMBER: Not applicable. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Elsokary, Eman Atef AU - Elsokary EA AD - Lecturer of Maternal and Newborn Health Nursing, Faculty of Nursing, Capital University, Egypt. Electronic address: Eman_atef@nursing.helwan.edu.eg. FAU - Afify, Sahar Shafeek Mohamed AU - Afify SSM AD - Lecturer of Obstetrics and Gynecology Nursing, Faculty of Nursing, Benha University, Egypt. Electronic address: sahar.afify@fnur.bu.edu.eg. FAU - Mohamed, Ahmed Zaher AU - Mohamed AZ AD - Department of Psychiatric and Mental Health Nursing, Faculty of Nursing, Ain Shams University, Cairo, Egypt. Electronic address: dr.ahmed.zaher@nursing.asu.edu.eg. FAU - Elkady, Ahmed Zinhom AU - Elkady AZ AD - North Private College of Nursing, Nursing Department, Arar, Northern Borders Region, Saudi Arabia. Electronic address: ahmadzinhom@nec.edu.sa. FAU - Khalil, Marwa Ibrahim Mahfouz AU - Khalil MIM AD - Professor of Gerontological Nursing, Faculty of Nursing, Alexandria University, Egypt. Electronic address: marwa-mahfouz@alexu.edu.eg. FAU - Hassan, Mai Mahmoud AU - Hassan MM AD - Assistant Professor of Obstetrics and Gynecology Nursing, Faculty of Nursing, Benha University, Egypt. Electronic address: mai.mahmoud@fnur.bu.edu.eg. LA - eng PT - Journal Article DEP - 20260605 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - *Breast Feeding/psychology/methods MH - Female MH - Egypt MH - Adult MH - *Self Efficacy MH - *Mothers/psychology/education MH - *Counseling/standards/methods MH - *Clinical Competence/standards MH - Cross-Sectional Studies MH - Postpartum Period MH - Pregnancy MH - Infant, Newborn OTO - NOTNLM OT - Breastfeeding self-efficacy OT - Counseling competence OT - Exclusive breastfeeding OT - Low- and middle-income countries OT - Nurse-led training OT - Postpartum care COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/09 00:34 MHDA- 2026/07/08 12:56 CRDT- 2026/06/08 18:09 PHST- 2026/02/18 00:00 [received] PHST- 2026/06/03 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/07/08 12:56 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 18:09 [entrez] AID - S0266-6138(26)00194-4 [pii] AID - 10.1016/j.midw.2026.104890 [doi] PST - ppublish SO - Midwifery. 2026 Sep;160:104890. doi: 10.1016/j.midw.2026.104890. Epub 2026 Jun 5. PMID- 42259017 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 148 IP - 4 DP - 2026 Aug TI - Analysis of clinical pedigree characteristics in Chinese patients with ataxia with vitamin E deficiency. PG - 110167 LID - S1096-7192(26)00450-6 [pii] LID - 10.1016/j.ymgme.2026.110167 [doi] AB - The clinical and genetic features of ataxia with isolated vitamin E deficiency (AVED) patients in Chinese are remain not well understood. We enrolled 120 unrelated probands with clinically suspected autosomal recessive cerebellar ataxia (ARCA) at the Department of Neurology, China-Japan Friendship Hospital between 2014 and 2024. all probands underwent Whole-exome sequencing (WES), with candidate variants validated by Sanger sequencing and family cosegregation analysis. In silico pathogenicity analysis, including protein structure homology modeling and multispecies conservation analysis, was performed for novel variants. Plasma vitamin E levels were measured using high-performance liquid chromatography with diode array detection(HPLC-DAD). We identified 4 probands with biallelic TTPA variants, accounting for 3.33% of the ARCA cohort. Three probands were from consanguineous families, and 1 was from non- consanguineous family. The median age at onset was 15years (range 14-23years), with gait instability/ataxia as the universal initial symptom. Core clinical features included cerebellar ataxia (4/4), dysarthria (4/4), areflexia (2/4), scoliosis (4/4), foot deformity (3/4), and head titubation (3/4). Brain MRI revealed cerebellar atrophy in 3 patients, and all had markedly reduced serum vitamin E levels. We identified 2 novel missense variants (c.265C>A(p.P89T) and c.790A>G(p.M264V)). All patients received high-dose vitamin E supplementation, with 3/4 improved ataxia symptoms at 2-years follow-up. Our findings expand the clinical and genetic spectrum of AVED in China and support early evaluation of plasma vitamin E status and TTPA variants in patients with unexplained sporadic or recessive ataxia, as well as proactive screening of siblings and other at-risk relatives, even before symptom onset. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Lv, Pu AU - Lv P AD - Department of Geriatric, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Liu, Lu AU - Liu L AD - Department of Geriatric, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Hao, Ying AU - Hao Y AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 10029, China. FAU - Zhou, Zhi AU - Zhou Z AD - Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Chen, Xin AU - Chen X AD - Department of Geriatric, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Zhang, Linwei AU - Zhang L AD - Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China. Electronic address: zhanglw999@hotmail.com. LA - eng PT - Journal Article DEP - 20260603 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 RN - 0 (alpha-tocopherol transfer protein) RN - 1406-18-4 (Vitamin E) RN - 0 (Carrier Proteins) RN - Ataxia with vitamin E deficiency RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Cerebellar Ataxia/genetics/pathology MH - China MH - Exome Sequencing MH - Mutation MH - Pedigree MH - Vitamin E/blood MH - *Vitamin E Deficiency/genetics/pathology/blood MH - East Asian People/genetics MH - Ataxia MH - Carrier Proteins OTO - NOTNLM OT - Cerebellar ataxia OT - Cerebellar atrophy OT - Mutation OT - Phenotype OT - TTPA gene COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/09 00:34 MHDA- 2026/07/16 12:40 CRDT- 2026/06/08 18:04 PHST- 2026/03/05 00:00 [received] PHST- 2026/05/23 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/07/16 12:40 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 18:04 [entrez] AID - S1096-7192(26)00450-6 [pii] AID - 10.1016/j.ymgme.2026.110167 [doi] PST - ppublish SO - Mol Genet Metab. 2026 Aug;148(4):110167. doi: 10.1016/j.ymgme.2026.110167. Epub 2026 Jun 3. PMID- 42258993 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 1532-2653 (Electronic) IS - 0967-5868 (Linking) VI - 152 DP - 2026 Oct TI - Quantitative hippocampal subfield volumetry using AID-HS in mesial temporal lobe epilepsy: correlation with histopathology. PG - 112129 LID - S0967-5868(26)00280-8 [pii] LID - 10.1016/j.jocn.2026.112129 [doi] AB - PURPOSE: To evaluate the diagnostic accuracy of the AID-HS pipeline in characterizing hippocampal subfield volumetric patterns and distinguishing HS subtypes, using histopathology as the reference standard in mesial temporal lobe epilepsy (mTLE). METHODS: Thirty patients with surgically treated mTLE underwent 3.0 T MRI. Volumetric subfield analysis was performed using the automated AID-HS tool.Hippocampal subfield volumes were compared between typical HS type 1 and atypical HS, including HS types 2 and 3, with validation against the 2013 ILAE histopathological criteria. Subfields of the sclerotic hippocampus were categorized as volume-reduced or volume-preserved based on the asymmetry index. RESULTS: HS type 1 was predominant, accounting for 83.3% of cases. In typical HS type 1, volume reduction in CA2 and CA3 was more frequently observed than in atypical HS on volumetric comparison, and MRI-detected volume reduction in CA2, CA3, and CA4 was significantly associated with histopathological sclerosis (p < 0.01) . Diagnostic accuracy showed fair to good classification performance for distinguishing HS subtypes, with AUC values ranging from 0.73 to 0.83. The CA3 subfield achieved the highest accuracy, with an AUC of 0.83 and 100% sensitivity. CONCLUSION: The AID-HS pipeline may provide quantitative support for subtype-oriented evaluation of HS. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Hung, Nguyen Duy AU - Hung ND AD - Department of Radiology, Hanoi Medical University, Ha Noi, Viet Nam; Department of Radiology, Viet Duc Hospital, Ha Noi, Viet Nam. Electronic address: duyhung@hmu.edu.vn. FAU - Minh Chau, Nguyen Thu AU - Minh Chau NT AD - Department of Radiology, Hanoi Medical University, Ha Noi, Viet Nam. Electronic address: thuminhchou@gmail.com. FAU - Van, Tran Dinh AU - Van TD AD - Department of Neurosurgery 1, Viet Duc Hospital, Ha Noi, Viet Nam. Electronic address: tranvanpttk@gmail.com. FAU - Ngan, Vuong Kim AU - Ngan VK AD - Department of Radiology, Hanoi Medical University, Ha Noi, Viet Nam; Department of Radiology, Vinmec Times City International Hospital, Vinmec Healthcare System, Ha Noi, Viet Nam. Electronic address: drkimngan.rad@gmail.com. LA - eng PT - Journal Article DEP - 20260608 PL - Scotland TA - J Clin Neurosci JT - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JID - 9433352 SB - IM MH - Humans MH - *Epilepsy, Temporal Lobe/pathology/diagnostic imaging/surgery MH - Female MH - Male MH - *Hippocampus/pathology/diagnostic imaging/surgery MH - *Magnetic Resonance Imaging/methods MH - Adult MH - Young Adult MH - Hippocampal Sclerosis/pathology MH - Middle Aged MH - Adolescent MH - Organ Size MH - Image Processing, Computer-Assisted/methods OTO - NOTNLM OT - Hippocampal sclerosis OT - Hippocampal subfields OT - Histopathology correlation OT - Magnetic resonance imaging OT - Mesial temporal lobe epilepsy OT - Quantitative MRI COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/08 19:43 MHDA- 2026/08/04 00:35 CRDT- 2026/06/08 18:03 PHST- 2026/02/20 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/06/08 19:43 [pubmed] PHST- 2026/06/08 18:03 [entrez] AID - S0967-5868(26)00280-8 [pii] AID - 10.1016/j.jocn.2026.112129 [doi] PST - ppublish SO - J Clin Neurosci. 2026 Oct;152:112129. doi: 10.1016/j.jocn.2026.112129. Epub 2026 Jun 8. PMID- 42258969 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260915 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Development and initial validation of the nursing practices, perceptions and barriers questionnaire for childhood obesity: A cross-sectional observational study. PG - 77-86 LID - S0882-5963(26)00252-6 [pii] LID - 10.1016/j.pedn.2026.05.045 [doi] AB - AIM: To develop and preliminarily validate a questionnaire assessing primary care nurses' practices, perceptions, and perceived barriers in managing childhood obesity. DESIGN: Sequential exploratory study conducted in three phases: item development, content validation, and a cross-sectional observational study with an initial psychometric validation. METHODS: Items were generated through a literature review, focus groups, and adaptation of an existing adult obesity instrument. A panel of six experts assessed content validity, clarity, coherence, and item adequacy. The final version 39-item questionnaire was distributed online to primary care nurses in Madrid, Spain; 253 complete responses were analyzed. Descriptive statistics were calculated. A preliminary Exploratory Factor Analysis was conducted on selected items. RESULTS: The overall content validity index was 0.96. The final instrument identified three areas: training and experience, practices and barriers, and knowledge of childhood obesity. Factor analyses supported coherent underlying dimensions for selected items, with acceptable internal consistency. Nurses reported positive attitudes toward addressing pediatric obesity but identified barriers such as limited consultation time, low treatment adherence, and intervention complexity. CONCLUSION: The NPPBQ-CO is a structured instrument with initial evidence of content validity, preliminary psychometric support and acceptable internal consistency. Further validation is warranted. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Miguel-Atanes, Cristina AU - Miguel-Atanes C AD - Department of Biological and Health Psychology, Faculty of Psychology, Autonomous University of Madrid, Spain. Electronic address: cristina.miguelatanes@gmail.com. FAU - Gomez-Lobo, Andrea Gil AU - Gomez-Lobo AG AD - Department of Biological and Health Psychology, Faculty of Psychology, Autonomous University of Madrid, Spain. Electronic address: andrea.gilg@uam.es. FAU - Solar, Maria AU - Solar M AD - TEA EDICIONES SAU, Madrid, Spain. FAU - Sepulveda, Ana Rosa AU - Sepulveda AR AD - Department of Biological and Health Psychology, Faculty of Psychology, Autonomous University of Madrid, Spain. Electronic address: anarosa.sepulveda@uam.es. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260608 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Female MH - *Pediatric Obesity/nursing/diagnosis MH - Psychometrics MH - Reproducibility of Results MH - Child MH - Spain MH - Male MH - *Pediatric Nursing MH - Adult MH - Attitude of Health Personnel MH - *Primary Care Nursing OTO - NOTNLM OT - Nursing care OT - Nursing, practical OT - Pediatric obesity OT - Primary health care OT - Surveys and questionnaires COIS- Declaration of competing interest There is no conflict of interest regarding the publication of this article. EDAT- 2026/06/08 19:42 MHDA- 2026/09/07 23:34 CRDT- 2026/06/08 18:02 PHST- 2025/11/25 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/06/08 19:42 [pubmed] PHST- 2026/06/08 18:02 [entrez] AID - S0882-5963(26)00252-6 [pii] AID - 10.1016/j.pedn.2026.05.045 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:77-86. doi: 10.1016/j.pedn.2026.05.045. Epub 2026 Jun 8. PMID- 42258527 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Spurious effects in random-intercept cross-lagged panel models: Results from simulations and reanalyses of data on self-esteem and problematic eating behaviors used by Beckers et al. (2023). PG - e0351302 LID - 10.1371/journal.pone.0351302 [doi] LID - e0351302 AB - The random-intercept cross-lagged panel model (RI-CLPM) is an extension of the traditional cross-lagged panel model. The RI-CPLM specifically addresses prospective effects within individuals. In the present simulations, we found that the RI-CLPM is susceptible to spurious findings when observed scores on the two variables are affected by common auto-correlated state factors. In reanalyses of empirical data, we found contradictory decreasing, increasing, and null prospective effects between within-individual levels of self-esteem and problematic eating behaviors among Dutch teenagers (N = 1856). These contradictory findings indicated that previously reported prospective effects may have been statistical artifacts. Caution is advised when using the RI-CLPM, as it may produce misleading results. Researchers are recommended to validate findings using alternative analyses, e.g., by examining person-mean centered scores. CI - Copyright: (c) 2026 Sorjonen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sorjonen, Kimmo AU - Sorjonen K AUID- ORCID: 0000-0001-9930-057X AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Nilsonne, Gustav AU - Nilsonne G AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. AD - Department of Psychology, Stockholm University, Stockholm, Sweden. FAU - Ghaderi, Ata AU - Ghaderi A AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Melin, Bo AU - Melin B AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20260608 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Self Concept MH - Adolescent MH - *Feeding Behavior/psychology MH - Female MH - *Feeding and Eating Disorders/psychology PMC - PMC13245769 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/08 19:39 MHDA- 2026/06/15 11:30 PMCR- 2026/06/08 CRDT- 2026/06/08 13:44 PHST- 2025/08/04 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/06/15 11:30 [medline] PHST- 2026/06/08 19:39 [pubmed] PHST- 2026/06/08 13:44 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - PONE-D-25-39381 [pii] AID - 10.1371/journal.pone.0351302 [doi] PST - epublish SO - PLoS One. 2026 Jun 8;21(6):e0351302. doi: 10.1371/journal.pone.0351302. eCollection 2026. PMID- 42258366 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260903 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Jun 8 TI - Social Partner Effects on Type 2 Diabetes Prevention, Management, and Spillover Health Outcomes: Single-Arm Pre-Post Pilot Intervention. PG - e82438 LID - 10.2196/82438 [doi] LID - e82438 AB - BACKGROUND: South Asian Americans are at high risk of prediabetes and type 2 diabetes mellitus (T2DM). South Asian populations are typically close-knit communities, with support networks that could be leveraged in lifestyle interventions. OBJECTIVE: This study was a single-arm, pre-post pilot study to evaluate the feasibility and efficacy of a culturally tailored telehealth intervention for South Asian adults with prediabetes or T2DM and their social partners (trusted household members) who agreed to complete preintervention and postintervention surveys. METHODS: Participants attended 5-hour-long health education sessions delivered in English and Bengali. Participant outcomes included pre-post changes in hemoglobin A1c (HbA1c), BMI, blood pressure (BP), self-reported minutes of physical activity, and dietary choices at baseline and at the 6-month follow-up. For social partners, outcomes included pre-post survey changes in physical activity and dietary choices. We used Pearson chi-square tests and paired 2-tailed t tests to compare baseline measures with postintervention outcomes. RESULTS: This pilot study included 54 participants and 106 social partners in Atlanta, Georgia, between March 2021 and November 2023. All participants were Bangladeshi and spoke native Bengali. Social partners were most commonly participants' children (39/106, 36.8%) or spouses (34/106, 32.1%). The participant baseline HbA1c level was 7.5% (SD 1.48%), which decreased by -0.83% (95% CI 0.42%-1.30%; P<.001). Participants also improved systolic BP by -5.8 mm Hg (95% CI 0.196-11.37; P=.04) with no change in diastolic BP (-0.451 mm Hg, 95% CI -1.49 to 2.39; P=.60) or BMI (-0.642 kg/m2, 95% CI -1.87 to 0.59; P=.17). Compared with baseline, 39% more participants exercised at least 150 minutes weekly (P<.001), but there was no difference in self-reported fruit and vegetable intake. However, the social partners increased fruit and vegetable intake (P=.02), decreased soda intake (P<.001), and increased daily moderate exercise (P=.003). CONCLUSIONS: Including social partners in T2DM prevention and management is feasible and potentially beneficial, but comparative studies are needed to determine the incremental effects of social partners' participation vs individual-focused lifestyle interventions. CI - (c) Natalie B Connell, Sakila Nasrin, Zohra Amin, Nazneen Akhet, Mohammed K Ali, K M Venkat Narayan, Megha Shah. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Connell, Natalie B AU - Connell NB AUID- ORCID: 0009-0002-6834-0143 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. FAU - Nasrin, Sakila AU - Nasrin S AUID- ORCID: 0009-0006-6127-0903 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. FAU - Amin, Zohra AU - Amin Z AUID- ORCID: 0009-0003-2246-5378 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. FAU - Akhter, Nazneen AU - Akhter N AUID- ORCID: 0009-0008-2871-0609 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. FAU - Ali, Mohammed K AU - Ali MK AUID- ORCID: 0000-0001-7266-2503 AD - Emory University, Emory Global Diabetes Research Center, Woodruff Health Sciences Center, Atlanta, GA, United States. FAU - Narayan, K M Venkat AU - Narayan KMV AUID- ORCID: 0000-0001-8621-5405 AD - Emory University, Emory Global Diabetes Research Center, Woodruff Health Sciences Center, Atlanta, GA, United States. FAU - Shah, Megha AU - Shah M AUID- ORCID: 0000-0002-6722-7846 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. LA - eng SI - ClinicalTrials.gov/NCT05275231 GR - K23 MD015088/MD/NIMHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260608 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 RN - 0 (Glycated Hemoglobin) SB - IM MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Diabetes Mellitus, Type 2/prevention & control/therapy/ethnology/psychology MH - Exercise MH - Glycated Hemoglobin/analysis MH - Pilot Projects MH - Asian MH - United States PMC - PMC13245547 OTO - NOTNLM OT - diabetes OT - household health benefits OT - lifestyle intervention OT - social networks OT - social partners COIS- Conflicts of Interest: None declared. EDAT- 2026/06/08 19:40 MHDA- 2026/06/11 12:40 PMCR- 2026/06/08 CRDT- 2026/06/08 12:44 PHST- 2025/08/14 00:00 [received] PHST- 2026/02/15 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/06/11 12:40 [medline] PHST- 2026/06/08 19:40 [pubmed] PHST- 2026/06/08 12:44 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - v10i1e82438 [pii] AID - 82438 [pii] AID - 10.2196/82438 [doi] PST - epublish SO - JMIR Form Res. 2026 Jun 8;10:e82438. doi: 10.2196/82438. PMID- 42258187 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 180 IP - 8 DP - 2026 Aug 1 TI - Smartphone Acquisition and Use at Age 13 Years and Health Outcomes at Age 14 Years. PG - 858-866 LID - 10.1001/jamapediatrics.2026.2118 [doi] AB - IMPORTANCE: Smartphone acquisition and use under age 13 years is common and has been linked to adverse health implications. Although delaying acquisition until after age 13 years is often recommended, evidence supporting this guideline remains limited. OBJECTIVE: To quantify the associations of smartphone acquisition around age 13 years and smartphone use with depression, obesity, and insufficient sleep at age 14 years. DESIGN, SETTING, AND PARTICIPANTS: In this cohort study of youth from the Adolescent Brain Cognitive Development Study, eligible participants were study participants who did not have a smartphone by the 13-year-old assessment. Mixed-effects regression models were applied to quantify associations of past-year smartphone acquisition and use with health outcomes adjusting for pre-exposure depression, obesity and sleep, multiple socioeconomic and parental confounders, and use of other devices. Analyses were conducted between November 2025 and April 2026. EXPOSURES: Smartphone acquisition and self-reported smartphone use duration (smartphone time). MAIN OUTCOMES: Odds ratios (ORs) for associations with depression diagnosis (based on a validated computerized diagnostic assessment), obesity (body mass index above 95th percentile), and insufficient sleep (less than 8 hours/night). RESULTS: Participants included 1959 youth (803 girls [41.0%]; 292 Black [14.9%], 314 Hispanic [16.0%], 1661 White [84.8%]) followed up from the 3-year (mean [SD] age, 12.7 [0.6] years) to the 4-year (mean [SD] age, 14.0 [0.7] years) assessment. Between the 3- and 4-year assessments, 1230 participants acquired a smartphone and 729 did not. Smartphone acquisition was not significantly associated with depression (OR, 1.45; 95% CI, 0.98-2.14) or obesity (OR, 1.02; 95% CI, 0.71-1.46), but was associated with insufficient sleep (OR, 1.29; 95% CI, 1.03-1.62) at follow-up. Among those who had acquired a smartphone, total smartphone time (standardized z score) was associated with depression (OR, 1.22; 95% CI, 1.01-1.80), obesity (OR, 1.34; 95% CI, 1.09-1.65), and insufficient sleep (OR, 1.28; 95% CI, 1.12-1.47). Placing smartphones outside the bedroom at bedtime was associated with lower odds of insufficient sleep (OR, 0.64; 95% CI, 0.47-0.87). CONCLUSIONS AND RELEVANCE: The results of this cohort study suggest that simply smartphone acquisition at age 13 years was not associated with depression or with obesity, but was associated with insufficient sleep at age 14 years; however, the amount of smartphone use was associated with higher odds of all 3 outcomes. Behavioral interventions like limiting smartphone time and keeping smartphones out of bedrooms at night may protect adolescents from potential adverse health outcomes. Findings offer insights to guide caregivers on adolescent smartphone use and inform policies aimed at protecting youth, such as delaying smartphone acquisition until age 13 years. FAU - Bren, Ziv AU - Bren Z AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. FAU - Tran, Kate T AU - Tran KT AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. FAU - Visoki, Elina AU - Visoki E AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. FAU - Waasdorp, Tracy E AU - Waasdorp TE AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia. FAU - Moore, Tyler M AU - Moore TM AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia. FAU - Pimentel, Samuel D AU - Pimentel SD AD - Department of Statistics, University of California, Berkeley. FAU - Barzilay, Ran AU - Barzilay R AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia. LA - eng PT - Journal Article PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data MH - Adolescent MH - Female MH - Male MH - *Depression/epidemiology/etiology MH - *Obesity/epidemiology MH - Cohort Studies MH - *Pediatric Obesity/epidemiology MH - *Sleep Deprivation/epidemiology MH - Sleep Duration PMC - PMC13247848 COIS- Conflict of Interest Disclosures: Dr Visoki reported that her spouse is the founder and CEO of Kidas. Dr Barzilay reported grants from National Institute of Mental Health (NIMH) during the conduct of the study; he reported advisory board service with Children and Screens and with Taliaz Health, in which he also holds equity, outside the submitted work. No other disclosures were reported. EDAT- 2026/06/08 12:39 MHDA- 2026/08/03 12:42 PMCR- 2027/06/08 CRDT- 2026/06/08 11:33 PHST- 2026/08/03 12:42 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 11:33 [entrez] PHST- 2027/06/08 00:00 [pmc-release] AID - 2849461 [pii] AID - poi260030 [pii] AID - 10.1001/jamapediatrics.2026.2118 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Aug 1;180(8):858-866. doi: 10.1001/jamapediatrics.2026.2118. PMID- 42257889 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261028 IS - 1435-165X (Electronic) IS - 1018-8827 (Linking) VI - 35 IP - 9 DP - 2026 Sep TI - Impact of school physical activity on physical and mental health in children and adolescents: A Meta-analysis based on RE-AIM. PG - 2685-2702 LID - 10.1007/s00787-026-03069-5 [doi] AB - The RE-AIM framework was used to assess and analyze the impact of school physical activity on children and adolescents' physical and mental health. A search of PubMed, Cochrane Library, Embase, Scopus, EBSCO, and Web of Science was conducted from when the databases were created until December 2024. Articles included studies on school-based physical activity interventions and physical and mental health of children and adolescents. The screened literature was evaluated for quality, data extraction, standardized mean difference (SMD), Mean difference(MD) and confidence intervals (95% CI) were used as effect indicators. Two researchers independently screened the literature, extracted data, and assessed the risk of bias for the included studies. Preferred reporting items were used using systematic evaluation and meta-analysis guidelines combined with meta-analysis with the RE-AIM framework. A total of 19 studies that met the inclusion criteria were included in the meta-analysis, and the results of the meta-analysis showed that school physical activity improved adolescents' and children's athletic ability (SMD = 0.33, 95% CI = 0.23 ~ 0.43), reduced BMI (MD=-0.50, 95% CI=-0.81~-0.19) and improved Fitness self-perceptions (SMD = 0.31, 95% CI = 0.22 ~ 0.40). In terms of mental health, school physical activity improved children and adolescents' self-reported questionnaire scores (SMD = 0.21,95%CI = 0.12 ~ 0.30) and reduced anxiety, depression and stress levels (MD=-0.53,95%CI=-0.85~-0.22). That is, school physical activity is associated with improvements in both physical health and the mental health of adolescents and children. In addition, the RE-AIM framework reported the effectiveness of sports interventions on health, with higher proportions of the Reach, Efficacy, and Adoption dimensions in the RE-AIM framework than in Implementation and Maintenance. A comprehensive assessment of the impact of school physical activity was conducted through meta-analysis and RE-AIM framework, which showed that school physical activity is associated with improvements in both the physical and mental health of children and adolescents and that RE-AIM framework reported the quality of physical activity interventions to improve the physical and mental health of children and adolescents, achieving a balance of internal and external validity in comparison. CI - (c) 2026. Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Li, Congcong AU - Li C AD - College of Sports Science, Shenyang Normal University, Shenyang, China. AD - Department of Physical Education, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Yezheng AU - Wang Y AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Zhao, Wei AU - Zhao W AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Yan, Xu AU - Yan X AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Liu, Kaihang AU - Liu K AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Zhong, Jingyi AU - Zhong J AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Wang, Liyan AU - Wang L AD - College of Rehabilitation, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Hongbiao AU - Wang H AD - Department of Physical Education, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Lijuan AU - Wang L AD - College of Sports Science, Shenyang Normal University, Shenyang, China. wlj_sunny@synu.edu.cn. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review DEP - 20260608 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Exercise/psychology MH - *Mental Health MH - *Schools MH - *Physical Fitness OTO - NOTNLM OT - Adolescents OT - Children OT - Mental health OT - Physical activity OT - Physical health OT - School interventions COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/08 12:39 MHDA- 2026/10/25 03:35 CRDT- 2026/06/08 11:13 PHST- 2025/05/22 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/10/25 03:35 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 11:13 [entrez] AID - 10.1007/s00787-026-03069-5 [pii] AID - 10.1007/s00787-026-03069-5 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2026 Sep;35(9):2685-2702. doi: 10.1007/s00787-026-03069-5. Epub 2026 Jun 8. PMID- 42257240 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1473-0766 (Electronic) IS - 0951-3590 (Linking) VI - 42 IP - 1 DP - 2026 Dec 31 TI - Association between GLM7 and female infertility: a cross-sectional analysis of NHANES 2013-2018. PG - 2686485 LID - 10.1080/09513590.2026.2686485 [doi] AB - OBJECTIVE: Female infertility is a common reproductive disorder influenced by metabolic dysfunction. The glycolipid metabolism 7 factors (GLM7) is a composite metabolic index integrating age, BMI, glucose, insulin, and lipid profiles. This study aimed to examine its association with female infertility in a nationally representative population. METHODS: Data from 1,405 female participants aged 18-45 years from the 2013-2018 cycles of the National Health and Nutrition Examination Survey were analyzed. We used survey-weighted logistic regression models and restricted cubic splines to assess the association between GLM7 and infertility. Receiver operating characteristic (ROC) curves were used to assess the diagnostic accuracy. RESULTS: A total of 167 participants (11.9%) reported infertility. After full adjustment, higher GLM7 levels were independently associated with increased odds of infertility (odds ratio (OR) = 1.401, 95% CI: 1.028-1.909, p = 0.034). A positive linear association was observed, with a potential plateau effect at GLM7 approximately 6.98. GLM7 showed modest discriminative ability (AUC = 0.596, 95%CI: 0.552-0.639). CONCLUSIONS: GLM7 was positively associated with female infertility. As a multidimensional metabolic indicator, GLM7 may provide complementary information for reproductive health research. However, its modest discriminative performance suggests limited value as a standalone screening tool, warranting further validation in longitudinal and clinical studies. FAU - Dong, Tingting AU - Dong T AUID- ORCID: 0000-0003-1035-6687 AD - Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, People's Republic of China. FAU - Gao, Jie AU - Gao J AUID- ORCID: 0009-0006-8586-0772 AD - School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People's Republic of China. FAU - Wang, Xietong AU - Wang X AUID- ORCID: 0009-0006-3301-9105 AD - Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, People's Republic of China. AD - Shandong Provincial Maternal and Child Health Care Hospital, Jinan, Shandong Province, People's Republic of China. AD - Key Laboratory of Maternal-Fetal Medicine of National Health Commission of China, Maternal and Child Health Care Hospital of Shandong Province Affiliated with Qingdao University, Qingdao University, Jinan, Shandong Province, People's Republic of China. LA - eng PT - Journal Article DEP - 20260608 PL - England TA - Gynecol Endocrinol JT - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JID - 8807913 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Adult MH - *Infertility, Female/blood/epidemiology/metabolism MH - Cross-Sectional Studies MH - Young Adult MH - Nutrition Surveys MH - Adolescent MH - Middle Aged MH - United States/epidemiology MH - Body Mass Index MH - Blood Glucose/metabolism OTO - NOTNLM OT - Female OT - GLM7 OT - glycolipid metabolism OT - infertility OT - reproductive health EDAT- 2026/06/08 12:39 MHDA- 2026/06/12 06:37 CRDT- 2026/06/08 07:47 PHST- 2026/06/12 06:37 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:47 [entrez] AID - 10.1080/09513590.2026.2686485 [doi] PST - ppublish SO - Gynecol Endocrinol. 2026 Dec 31;42(1):2686485. doi: 10.1080/09513590.2026.2686485. Epub 2026 Jun 8. PMID- 42257148 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 15 IP - 3 DP - 2026 Mar TI - Exploring the effects of high fat, salt, and sugar (HFSS) food consumption among undergraduate medical students: A cross-sectional study. PG - 1306-1314 LID - 10.4103/jfmpc.jfmpc_94_25 [doi] AB - BACKGROUND: Adolescents who are overweight or obese are more likely to develop non-communicable diseases (NCDs) in their early adult years, including diabetes, cardiovascular disease, hypertension, and dyslipidaemia. To address the growing epidemic of childhood and adult obesity, immediate action is needed. Obesity and the prevalence of non-communicable diseases are strongly linked to eating habits. METHODOLOGY: A pre-tested, validated questionnaire was circulated among undergraduate MBBS students from various medical colleges. RESULTS: One hundred seventy MBBS students from four other medical colleges participated in this online survey. The questionnaire was circulated via Google Forms. The mean age of participants was 21.57 (+1.47). Zomato (57, 33%) and Swiggy (52, 31%) were the most used applications by the participants. One hundred thirty-four (79%) participants had incorrect knowledge about added sugar in the diet cola drinks. One hundred nineteen (70%) participants had incorrect knowledge about added salt in bread. Thirty-five of 107 (33%) females had a waist hip ratio (WHR) of more than 0.85, and 15/63 (24%) males had a WHR of more than 0.90, which implies an increased chance of obesity, cardiovascular risks, and other non-communicable diseases in the future. CONCLUSION: The study reveals a high prevalence of HFSS food consumption among undergraduate medical students, with online food delivery platforms playing a central role in facilitating this dietary behaviour. CI - Copyright: (c) 2026 Journal of Family Medicine and Primary Care. FAU - Singh, Garima AU - Singh G AD - Department of Community Medicine, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh, India. FAU - Jaiswal, Abhishek AU - Jaiswal A AD - Department of Community Medicine, Banaras Hindu University, Varanasi, Uttar Pradesh, India. LA - eng PT - Journal Article DEP - 20260420 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC13241118 OTO - NOTNLM OT - Fast food consumption OT - non-communicable diseases OT - obesity COIS- There are no conflicts of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/03/01 CRDT- 2026/06/08 07:46 PHST- 2025/01/15 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:46 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - JFMPC-15-1306 [pii] AID - 10.4103/jfmpc.jfmpc_94_25 [doi] PST - ppublish SO - J Family Med Prim Care. 2026 Mar;15(3):1306-1314. doi: 10.4103/jfmpc.jfmpc_94_25. Epub 2026 Apr 20. PMID- 42257122 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 15 IP - 3 DP - 2026 Mar TI - Screen time and its determinants among adolescents in Chennai: A cross-sectional study. PG - 1160-1164 LID - 10.4103/jfmpc.jfmpc_442_25 [doi] AB - BACKGROUND: Screen time (ST) has become a critical factor influencing adolescent health. With the rapid expansion of smartphones, tablets, computers and internet access, the ways in which they interact with their environment have undergone massive transformation. This study focuses on the use of screen time and its association with demographic and lifestyle factors in Chennai, India. METHODS: The study was a descriptive cross-sectional study among 610 adolescents (53.3% from government aided schools and 46.7% from private school) from Chennai. Data was collected using structured proforma and validated questionnaire (QueST) that was then analysed for ST determinants. RESULTS: The study revealed an average ST of 2.45 +/- 1.19 hours on weekdays and 4.21 +/- 1.94 hours on weekends. Recreational activities such as video, gaming and social media were the predominant contributors. Increased ST (>2 hours/day) was significantly associated with age (17 years), gender (female), type of school (private), decreased sleep duration, absence of physical activity, incomplete homework, lack of peer interaction, spectacle use and overweight/obesity. CONCLUSION: The average ST spent by adolescents is more than the recommendation. This study highlights the need for optimal ST practices for promoting a balanced lifestyle among Adolescents. CI - Copyright: (c) 2026 Journal of Family Medicine and Primary Care. FAU - Amuthan, Shwetha AU - Amuthan S AD - Senior Resident, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. FAU - Mohan, Ram AU - Mohan R AD - Assistant Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. FAU - Ravichandran, Latha AU - Ravichandran L AD - Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. FAU - Premkumar, Sarala AU - Premkumar S AD - Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260420 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC13241144 OTO - NOTNLM OT - Adolescents OT - BMI OT - Chennai OT - physical activity OT - screentime COIS- There are no conflicts of interest. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2026/03/01 CRDT- 2026/06/08 07:46 PHST- 2025/03/17 00:00 [received] PHST- 2025/10/25 00:00 [revised] PHST- 2025/11/03 00:00 [accepted] PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:46 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - JFMPC-15-1160 [pii] AID - 10.4103/jfmpc.jfmpc_442_25 [doi] PST - ppublish SO - J Family Med Prim Care. 2026 Mar;15(3):1160-1164. doi: 10.4103/jfmpc.jfmpc_442_25. Epub 2026 Apr 20. PMID- 42256855 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 1662-5153 (Print) IS - 1662-5153 (Electronic) IS - 1662-5153 (Linking) VI - 20 DP - 2026 TI - Quantum-entangled feature selection and spiking graph transformer networks for early detection of childhood behavioral markers. PG - 1797210 LID - 10.3389/fnbeh.2026.1797210 [doi] LID - 1797210 AB - INTRODUCTION: Early identification of childhood behavioural markers using wearable sensing is important for timely intervention in developmental and sleep-related disorders. Wrist-worn accelerometer data provide objective measures of behavioural regulation by capturing actigraphy-derived states such as Sleep, Wake, and Transitional periods. However, existing deep learning methods for behavioural state detection often face challenges related to redundant features, sensitivity to sensor noise, limited robustness in long-term wearable deployment, and high energy consumption. METHODS: This study proposes a Quantum Variational Feature Selection-Spiking Graph Transformer Network (QVFS-SGTN), a hybrid quantum-neuromorphic framework for robust and energy-efficient behavioural state classification. The prediction task was defined as a three-class classification problem involving Sleep, Wake, and Transitional behavioural states from high-frequency wrist-worn accelerometer data. The proposed model integrates a parameterized quantum circuit-based feature selector to identify non-linear and entangled sensor correlations. Selected features are then processed by a spiking graph transformer network, which models temporal dependencies through event-driven self-attention and neuromorphic neuron dynamics. Experiments were conducted using the Child Mind Institute wearable dataset, with additional cross-dataset validation performed on the external Multi-Ethnic Study of Atherosclerosis sleep dataset. RESULTS: The proposed QVFS-SGTN framework achieved state-of-the-art performance on the Child Mind Institute wearable dataset, with an accuracy of 0.968, an F1-score of 0.968, and an AUC of 0.991. Robustness evaluation demonstrated stable performance under significant Gaussian noise, maintaining accuracy above 92%. Energy analysis showed a 40-55% reduction in computational cost compared with conventional deep learning models. In cross-dataset evaluation using the MESA sleep dataset, the model achieved an accuracy of 0.931 without fine-tuning, indicating strong generalization capability. DISCUSSION: The findings demonstrate that combining quantum-enhanced feature selection with spiking graph-based temporal modelling can improve the robustness, accuracy, and energy efficiency of wearable behavioural state detection. The QVFS-SGTN framework effectively addresses key limitations of existing deep learning approaches, including feature redundancy, sensor noise sensitivity, and computational cost. These results support the potential of the proposed hybrid quantum-neuromorphic model for scalable, long-term, real-world paediatric behavioural monitoring. CI - Copyright (c) 2026 M, Joseph, Patil and K. FAU - M, Karthiga AU - M K AD - Department of Computer Science and Engineering, Bannari Amman Institute of Technology, Sathyamangalam, Tamil Nadu, India. AD - Postdoctoral Researcher, Multimedia University, Melaka, Malaysia. FAU - Joseph, Emerson Raja AU - Joseph ER AD - Faculty of Engineering and Technology Centre for Advanced Analytics, COE of Artificial Intelligence, Multimedia University, Melaka, Malaysia. FAU - Patil, Subhash AU - Patil S AD - Department of Surgery, International Medical University, Management and Science University, Shah Alam, Malaysia. FAU - K, Saranya AU - K S AD - Department of Computer Science and Engineering, Bannari Amman Institute of Technology, Sathyamangalam, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260522 PL - Switzerland TA - Front Behav Neurosci JT - Frontiers in behavioral neuroscience JID - 101477952 PMC - PMC13236668 OTO - NOTNLM OT - childhood behavioral markers OT - graph transformer OT - neuromorphic computing OT - quantum variational feature selection OT - sleep-wake detection OT - spiking neural networks OT - wearable accelerometers COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2026/05/22 CRDT- 2026/06/08 07:44 PHST- 2026/01/27 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:44 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.3389/fnbeh.2026.1797210 [doi] PST - epublish SO - Front Behav Neurosci. 2026 May 22;20:1797210. doi: 10.3389/fnbeh.2026.1797210. eCollection 2026. PMID- 42256484 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2421-4248 (Electronic) IS - 1121-2233 (Print) IS - 1121-2233 (Linking) VI - 66 IP - 4 DP - 2025 Dec TI - The digital tether: a SA-SV based survey on smartphone addiction among young adults in Southern Italy. PG - E466-E478 LID - 10.15167/2421-4248/jpmh2025.66.4.3771 [doi] AB - INTRODUCTION: In the post-pandemic era, smartphone usage has surged globally, particularly among young adults. While these devices offer convenience and connectivity, their excessive use has raised concerns about behavioral addiction and psychological well-being. This study investigates the prevalence of problematic smartphone use among young adults in Southern Italy, focusing on usage patterns and socio-demographic correlations. METHODS: A cross-sectional survey was conducted between March and June 2025 using an anonymous online questionnaire. The instrument combined ad hoc questions on lifestyle and digital habits with the validated Smartphone Addiction Scale-Short Version (SAS-SV). Participants aged 18-40 were recruited primarily from Sicily and Calabria via university and community networks. Data were analyzed using non-parametric statistical tests and chi-square analysis. RESULTS: The final sample included 451 respondents (average age: 22.42 years), predominantly Italian and non-working students. The SAS-SV identified smartphone addiction in 21.3% of participants, with no significant gender differences. Most users engaged with smartphones for leisure, social media, and entertainment. Significant associations were found between SAS scores and variables such as region, education level, and income. Notably, higher scores correlated with emotional reliance on smartphones and difficulty disengaging from use. CONCLUSION: Problematic smartphone use affects over one-fifth of young adults in Southern Italy, driven more by app features than screen time alone. These findings underscore the need for targeted public health strategies, including early screening and behavioral interventions, to address digital dependency and promote healthier technology habits in this demographic. CI - (c)2026 Pacini Editore SRL, Pisa, Italy. FAU - Venuto, Roberto AU - Venuto R AD - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy. AD - Department of Prevention, Local Health Authority of Messina, Messina, Italy. FAU - Rizzo, Caterina Elisabetta AU - Rizzo CE AD - Department of Prevention, Local Health Authority of Messina, Messina, Italy. AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Genovese, Giovanni AU - Genovese G AD - Department of Prevention, Local Health Authority of Messina, Messina, Italy. AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Trimarchi, Giuseppe AU - Trimarchi G AD - SIR, University of Messina, Messina, Italy. FAU - LA Spada, Giuseppe AU - LA Spada G AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Squeri, Raffaele AU - Squeri R AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - LA Fauci, Vincenza AU - LA Fauci V AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Genovese, Cristina AU - Genovese C AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. LA - eng PT - Journal Article DEP - 20260228 PL - Italy TA - J Prev Med Hyg JT - Journal of preventive medicine and hygiene JID - 9214440 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data MH - Italy/epidemiology MH - Female MH - Young Adult MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - Surveys and Questionnaires MH - *Internet Addiction Disorder/epidemiology MH - Adult MH - *Behavior, Addictive/epidemiology MH - Prevalence MH - Digital Media PMC - PMC13235401 OTO - NOTNLM OT - Digital behavior OT - SAS-SV OT - Smartphone addiction OT - Smartphone problematic use OT - Young adults COIS- The authors declare no conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/12 06:39 PMCR- 2026/02/28 CRDT- 2026/06/08 07:41 PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:41 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - 10.15167/2421-4248/jpmh2025.66.4.3771 [doi] PST - epublish SO - J Prev Med Hyg. 2026 Feb 28;66(4):E466-E478. doi: 10.15167/2421-4248/jpmh2025.66.4.3771. eCollection 2025 Dec. PMID- 42256013 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2641-7804 (Electronic) IS - 2641-7804 (Linking) VI - 7 IP - 4 DP - 2025 TI - Associations Between Social Media Usage, Physical Activity and Flourishing in Rural University Students. PG - 128-136 LID - 10.13023/jah.0704.08 [doi] AB - INTRODUCTION: Most adolescents and young adults report significant use of social media.1-3 However, there is limited research on the effect of social media use, specifically on physical activity and flourishing. PURPOSE: This pilot research study examines the correlation between social media usage and the physical activity and flourishing levels of college students at a rural university in Appalachia. METHODS: The authors conducted a survey including the validated Secure Flourishing Index and Stanford Leisure-Time Activity Categorical Item, containing questions on social media use and demographics. Spearman's rho was used for nonparametric correlations. Pearson's correlation was used to determine the correlation of flourishing with physical activity levels. RESULTS: Time spent on Threads per login was positively associated with higher physical activity (pppp <0.001). Implications: Social media use, both frequency and time spent on the platforms, can impact how college students attending a rural university flourish and participate in physical activity. Continued research in this area should investigate the content on social media for its impact on different domains of flourishing including physical and mental health. CI - Copyright (c) 2025 Anna Dysart and Minu Sara Thomas. FAU - Dysart, Anna AU - Dysart A AD - Western Carolina University. FAU - Thomas, Minu Sara AU - Thomas MS AD - Western Carolina University. LA - eng PT - Journal Article DEP - 20251201 PL - United States TA - J Appalach Health JT - Journal of Appalachian health JID - 101747123 PMC - PMC13239628 OTO - NOTNLM OT - Appalachia OT - college students OT - flourishing OT - health OT - physical activity OT - social media COIS- Cover Page Footnote: No competing financial or editorial interests were reported by the authors of this paper. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2025/12/01 CRDT- 2026/06/08 07:37 PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:37 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - jah-7-4-128 [pii] AID - 10.13023/jah.0704.08 [doi] PST - epublish SO - J Appalach Health. 2025 Dec 1;7(4):128-136. doi: 10.13023/jah.0704.08. eCollection 2025. PMID- 42255899 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Genotype-phenotype correlations in EPCAM-associated congenital tufting enteropathy: a case report and systematic review. PG - 1830464 LID - 10.3389/fped.2026.1830464 [doi] LID - 1830464 AB - BACKGROUND: Congenital tufting enteropathy (CTE) is a rare autosomal-recessive enteropathy caused by EPCAM variants. While the clinical spectrum ranges from intractable diarrhea to manageable outcomes, the genotype-phenotype correlation remains undefined. METHODS: We report a case of an infant diagnosed with CTE carrying a novel frameshift variant (c.315delT), and present a systematic review of previously published molecularly confirmed cases. Genotypes were stratified into truncating (nonsense, frameshift, large deletions) and non-truncating (missense, splicing, in-frame indel) groups to assess their impact on intestinal failure severity. RESULTS: The index patient, carrying a homozygous truncating variant, presented with severe malnutrition and intestinal failure. In the pooled cohort (n = 150), truncating variants were significantly associated with dependency on total parenteral nutrition (TPN) compared to non-truncating variants (OR 2.37, 95% CI 1.15-4.90, p = 0.020). Sensitivity analysis supported this association (OR 2.42, 95% CI 1.07-5.47, p = 0.045). Geographically, truncating variants were enriched in the Eastern Mediterranean Region (OR 9.32, p < 0.001). CONCLUSIONS: Truncating EPCAM variants showed a preliminary but significant clinical association with severe intestinal failure requiring TPN. These findings support early risk stratification for aggressive nutritional management but warrant further validation in prospective cohorts. CI - (c) 2026 Zhao, Zheng, Liu, Liu, Lu and Yan. FAU - Zhao, Liqian AU - Zhao L AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zheng, Yucan AU - Zheng Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Liu, Hao AU - Liu H AD - Department of Infection, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Liu, Zhifeng AU - Liu Z AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Lu, Yan AU - Lu Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Yan, Kunlong AU - Yan K AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260521 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13233504 OTO - NOTNLM OT - EPCAM OT - congenital tufting enteropathy OT - genotype-phenotype analysis OT - intestinal failure OT - parenteral nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/05/21 CRDT- 2026/06/08 07:36 PHST- 2026/03/14 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:36 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.3389/fped.2026.1830464 [doi] PST - epublish SO - Front Pediatr. 2026 May 21;14:1830464. doi: 10.3389/fped.2026.1830464. eCollection 2026. PMID- 42255703 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260922 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 6 DP - 2026 Jun TI - Development and Optimization of Instant Cassava-Soybean Composite Porridge as a Nutrient-Enhanced Complementary Food for Children Aged 6-59 Months. PG - e71957 LID - 10.1002/fsn3.71957 [doi] LID - e71957 AB - Childhood malnutrition remains a significant challenge in sub-Saharan Africa, particularly in regions where cassava is a staple. Despite its prevalence, cassava is an inadequate complementary food for children aged 6-59 months due to its low protein content, persistent cyanogenic glucosides, and high-viscosity, low-nutrient density. This study aimed to develop and optimize an instant cassava-soybean composite porridge using extrusion cooking. Using a mixture design to evaluate nine formulations against WHO nutrient recommendations, a 70:30 cassava-to-soybean ratio was identified as optimal. A central composite design involving 21 experimental runs further optimized extrusion conditions by varying barrel temperature (BT) (60 degrees C-150 degrees C) and feed moisture (16%-30%). The ideal extrusion parameters were determined to be a 145.6 degrees C (BT) and 19.7% feed moisture. The resulting flour contained 12.04% protein with 70.9% digestibility, 8.42% moisture, and a viscosity of 1086.63 cP. Notably, extrusion significantly reduced cyanogenic glucosides, enhancing product safety. Sensory evaluation by a semi-trained panel of 30 adults using a 9-point hedonic scale indicated high consumer appeal, with overall acceptability and texture scores of 7.3 and 7.4, respectively (𝑝 < 0.05). Cost analysis showed the final product is 56%-65% cheaper than commercial alternatives like Cerelac. In summary, this optimized porridge complies with WHO guidelines for complementary foods, offering a feasible, safe, and economical nutritional solution for cassava-consuming communities. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Mugabi, Robert AU - Mugabi R AUID- ORCID: 0000-0003-3218-3684 AD - Department of Food Technology and Nutrition, School of Food Technology, Nutrition and Bioengineering Makerere University Kampala Uganda. FAU - Arinaitwe, Catherine Byekwaso AU - Arinaitwe CB AD - Department of Food Technology and Nutrition, School of Food Technology, Nutrition and Bioengineering Makerere University Kampala Uganda. FAU - Mukisa, Ivan Muzira AU - Mukisa IM AD - Department of Food Technology and Nutrition, School of Food Technology, Nutrition and Bioengineering Makerere University Kampala Uganda. LA - eng PT - Journal Article DEP - 20260528 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13240348 OTO - NOTNLM OT - cassava-soybean composite OT - complementary food OT - extrusion cooking OT - infant nutrition OT - optimization OT - protein digestibility COIS- The authors declare no conflicts of interest. EDAT- 2026/06/08 12:40 MHDA- 2026/06/08 12:41 PMCR- 2026/05/28 CRDT- 2026/06/08 07:35 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/08 12:41 [medline] PHST- 2026/06/08 12:40 [pubmed] PHST- 2026/06/08 07:35 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - FSN371957 [pii] AID - 10.1002/fsn3.71957 [doi] PST - epublish SO - Food Sci Nutr. 2026 May 28;14(6):e71957. doi: 10.1002/fsn3.71957. eCollection 2026 Jun. PMID- 42254656 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Fecal microbiota composition concerning body mass index and early-life factors in Mexican preschool-aged children: a cross-sectional study. PG - e21253 LID - 10.7717/peerj.21253 [doi] LID - e21253 AB - BACKGROUND: The gut microbiota maturation extends beyond the first two years of life. Early perinatal and postnatal factors may influence the child's nutritional status, which, in turn, can affect the composition of their gut microbiota. METHODS: This cross-sectional study characterized the gut microbiota of 84 preschool children (ages 3 to 5) from semi-urban and urban areas in Veracruz, Mexico. Fecal samples were analyzed using 16S rRNA gene sequencing. Perinatal and early-life exposures were retrieved retrospectively using a validated, interviewer-administered questionnaire, while current anthropometric measurements and dietary patterns were evaluated. Children were classified by Body Mass Index (BMI) as underweight (UW), normal weight (NW), or overweight/obese (OW). RESULTS: Clinical factors such as prematurity and early feeding showed weak associations with BMI. The dietary patterns exhibited general homogeneity, showing a Western diet with no significant changes in relation to BMI. The predominant bacterial phyla were Bacillota and Bacteroidota across all BMI groups. Alpha diversity showed significant differences according to BMI categories, while no significant differences in beta diversity, or the relative abundance of major phyla, were observed. At the family level, Prevotellaceae was more abundant in underweight children, while Lachnospiraceae was more prevalent in those with higher BMI. However, these trends were not statistically significant. The findings suggest that, within this narrow age range and shared environment, gut microbiota composition is broadly similar regardless of BMI and dietary patterns, highlighting the complexity of microbiota-host interactions in early childhood. Further studies integrating functional analyses are needed to clarify the causal links between gut microbiota and a child's weight status. CI - (c)2026 Hernandez-Rodriguez et al. FAU - Hernandez-Rodriguez, Dolores AU - Hernandez-Rodriguez D AD - Instituto de Ciencias Basicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Contreras, Astrid AU - Contreras A AD - Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Melgar Lalanne, Guiomar AU - Melgar Lalanne G AD - Instituto de Ciencias Basicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Lara Arellano, Silvia Socorro AU - Lara Arellano SS AD - Facultad de Enfermeria, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Meza, Jose Enrique AU - Meza JE AD - Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Licona Cassani, Cuauhtemoc AU - Licona Cassani C AD - Departamento de Ingenieria Celular y Biocatalisis, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico. FAU - Viveros, Rubi AU - Viveros R AD - Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. LA - eng SI - figshare/10.6084/m9.figshare.30290248.v1 PT - Journal Article DEP - 20260603 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child, Preschool MH - Mexico MH - *Body Mass Index MH - Male MH - Female MH - *Feces/microbiology MH - *Gastrointestinal Microbiome MH - RNA, Ribosomal, 16S/genetics MH - Thinness/microbiology MH - Nutritional Status MH - Overweight/microbiology MH - Retrospective Studies PMC - PMC13242193 OTO - NOTNLM OT - Body mass index OT - Childhood OT - Clinical data OT - Gut microbiota OT - Nutritional status COIS- The authors declare there are no competing interests. EDAT- 2026/06/08 12:39 MHDA- 2026/06/11 18:36 PMCR- 2026/06/03 CRDT- 2026/06/08 07:25 PHST- 2025/10/15 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/06/11 18:36 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:25 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 21253 [pii] AID - 10.7717/peerj.21253 [doi] PST - epublish SO - PeerJ. 2026 Jun 3;14:e21253. doi: 10.7717/peerj.21253. eCollection 2026. PMID- 42254612 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Ontology-based dietary recommendation system for Chinese children and adolescents: development and a pilot validation study. PG - 1780898 LID - 10.3389/fpubh.2026.1780898 [doi] LID - 1780898 AB - BACKGROUND: Dietary imbalances among Chinese children and adolescents are prevalent, but most recommender systems are adult-oriented and not adapted to Chinese dietary patterns or school-family meal contexts. This study aims to developed and evaluated an ontology-based dietary recommendation system for Chinese children and adolescents to improve their dietary status. METHODS: An ontology knowledge base was constructed from dietary guidelines, expert knowledge, and food and meal data. A multi-criteria decision framework generated feasible meal plans, optimized portion sizes with a genetic algorithm, and selected solutions that promote food diversity. We conducted a preliminary evaluation of the system in two pilot settings: (1) a group-level experiment using 30 days of school lunch data from a primary school, and (2) an individual-level experiment using 30 days of dietary records and health check-up data from 30 middle school students. Diet quality was assessed using the Chinese Children Dietary Index (CCDI), nutrient adequacy rates, and food-group diversity. RESULTS: In the group experiment, system-recommended lunches achieved a significantly higher average CCDI score (117.39 +/- 6.61) than actual school lunches (103.41 +/- 9.44, p < 0.001). In the individual experiment, recommended full-day meals scored higher in CCDI (110.91 +/- 9.70) compared with self-selected diets (90.61 +/- 10.77, p < 0.001). Across both settings, the system reduced deficiencies in vegetables, fruits, and aquatic products with consistent improvements in nutrient adequacy and food diversity, while maintaining alignment with dietary guidelines. CONCLUSION: To the best of our knowledge, this study presents the first ontology-driven dietary recommendation system tailored for Chinese children and adolescents. By integrating structured knowledge representation with advanced decision-making algorithms, the system demonstrates promising improvements in dietary quality, nutritional balance, and food diversity across both school and family scenarios. These findings highlight the system's potential as a practical tool for promoting healthy eating behaviors, and informing nutrition education. CI - Copyright (c) 2026 Zhang, Xu, An, Yang, Xie and Deng. FAU - Zhang, Zhiyu AU - Zhang Z AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. FAU - Xu, Dongdong AU - Xu D AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. FAU - An, Jiye AU - An J AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. FAU - Yang, Min AU - Yang M AD - Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. AD - Center of Clinical Big Data and Analytics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. FAU - Xie, Sasa AU - Xie S AD - Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. AD - Center of Clinical Big Data and Analytics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. FAU - Deng, Ning AU - Deng N AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. AD - Binjiang Institute, Zhejiang University, Hangzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260522 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Pilot Projects MH - Child MH - Adolescent MH - China MH - Female MH - Male MH - *Nutrition Policy MH - *Diet MH - Schools MH - Knowledge Bases MH - East Asian People PMC - PMC13236952 OTO - NOTNLM OT - artificial intelligence OT - children and adolescents OT - dietary recommendation OT - multi-criteria decision-making OT - ontology COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/12 06:38 PMCR- 2026/05/22 CRDT- 2026/06/08 07:25 PHST- 2026/01/05 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/06/12 06:38 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:25 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1780898 [doi] PST - epublish SO - Front Public Health. 2026 May 22;14:1780898. doi: 10.3389/fpubh.2026.1780898. eCollection 2026. PMID- 42253746 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Serum BDNF as an integrative neuro-immunometabolic marker in adolescent polycystic ovary syndrome: divergent dietary and inflammatory associations across weight phenotypes. PG - 1830074 LID - 10.3389/fnut.2026.1830074 [doi] LID - 1830074 AB - BACKGROUND: Polycystic ovary syndrome (PCOS) in adolescence is characterized by hormonal imbalance, low-grade inflammation, oxidative stress, and metabolic dysfunction. Brain-derived neurotrophic factor (BDNF) regulates energy homeostasis and neuroimmune signaling and may act as a neuroimmunometabolic integrator in PCOS. METHODS: Forty adolescent females with PCOS (26 normal weight and 14 with overweight and obesity) were evaluated. Serum BDNF, omega-3 fatty acids (EPA, DHA), uric acid, metabolic and hormonal indices, and total antioxidant capacity (T-AOC) were measured. Dietary intake and physical activity were assessed using validated tools. RESULTS: Serum BDNF concentrations did not differ between BMI phenotypes. After FDR correction, significant dietary associations were observed only in normal-weight participants, including energy, protein, fat, and unsaturated fatty acids. No dietary associations remained significant in patients with overweight and obesity. Across both phenotypes, BDNF was positively associated with IL-1beta, MDA, T-AOC, EPA, and uric acid. IL-6, TNF-alpha, and DHA remained significant only in normal-weight participants. No associations were found with CRP, lipid profile, sex hormones, or glucose-insulin parameters. CONCLUSION: Circulating BDNF was associated with dietary, inflammatory, and oxidative parameters, with limited evidence for endocrine associations. These findings suggest that BDNF may reflect an integrated neuroimmunometabolic profile in adolescent PCOS and should be considered exploratory, requiring confirmation in longitudinal studies. CI - Copyright (c) 2026 Mizgier, Formanowicz, Sansoni, Jarzabek-Bielecka, Lombardi, Kedzia and Opydo-Szymaczek. FAU - Mizgier, Malgorzata AU - Mizgier M AD - Department of Sports Dietetics, Faculty of Health Sciences, Poznan University of Physical Education, Poznan, Poland. FAU - Formanowicz, Dorota AU - Formanowicz D AD - Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan, Poland. FAU - Sansoni, Veronica AU - Sansoni V AD - Laboratory of Experimental Biochemistry and Advanced Diagnostics, I.R.C.C.S. Ospedale Galeazzi-Sant'Ambrogio, Milano, Italy. FAU - Jarzabek-Bielecka, Grazyna AU - Jarzabek-Bielecka G AD - Division of Gynecology, Department of Gynecology, Center of General Sexology and Sexology of Developmental Age, Poznan University of Medical Sciences, Poznan, Poland. FAU - Lombardi, Giovanni AU - Lombardi G AD - Laboratory of Experimental Biochemistry and Advanced Diagnostics, I.R.C.C.S. Ospedale Galeazzi-Sant'Ambrogio, Milano, Italy. AD - Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland. FAU - Kedzia, Witold AU - Kedzia W AD - Division of Gynecology, Department of Gynecology, Center of General Sexology and Sexology of Developmental Age, Poznan University of Medical Sciences, Poznan, Poland. FAU - Opydo-Szymaczek, Justyna AU - Opydo-Szymaczek J AD - Department of Pediatric Dentistry, Poznan University of Medical Sciences, Poznan, Poland. LA - eng PT - Journal Article DEP - 20260521 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13233441 OTO - NOTNLM OT - BDNF OT - adolescence OT - antioxidant defence OT - diet OT - inflammation OT - insulin sensitivity OT - omega-3 fatty acids OT - oxidative stress COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author MM declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/05/21 CRDT- 2026/06/08 07:18 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:18 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1830074 [doi] PST - epublish SO - Front Nutr. 2026 May 21;13:1830074. doi: 10.3389/fnut.2026.1830074. eCollection 2026. PMID- 42253595 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Effects of a 12-week mini-basketball exercise intervention on executive function in children with attention-deficit/hyperactivity disorder: a randomized controlled trial. PG - 1840290 LID - 10.3389/fpsyg.2026.1840290 [doi] LID - 1840290 AB - BACKGROUND: Executive function (EF) deficits are a core cognitive impairment in children with ADHD. While physical exercise has been shown to benefit EF, the effects of cognitively engaging, sport-based interventions remain insufficiently understood. This study examined the effects of a 12-week mini-basketball intervention on EF in children with ADHD using a randomized controlled trial design. METHODS: Thirty-five children aged 6-11 years meeting DSM-5 criteria for ADHD were randomly assigned to an exercise group (EG, n = 18) or a control group (CG, n = 17). The EG participated in a 12-week moderate-intensity mini-basketball program (3 sessions/week, 45 min/session), whereas the CG maintained usual activities. Inhibitory control (IC), working memory (WM), and global EF were assessed at baseline and post-intervention using the Childhood Executive Functioning Inventory (CHEXI). Between-group differences were analyzed using ANCOVA controlling for baseline values. RESULTS: Compared with the CG, the EG demonstrated significantly greater improvements in IC (F = 15.15, p < 0.001, partial eta(2) = 0.35), WM (F = 30.55, p < 0.001, partial eta(2) = 0.52), and global EF (F = 40.68, p < 0.001, partial eta(2) = 0.59), all indicating large effect sizes. Within-group analyses showed significant improvements across all EF domains in the EG (all p < 0.05), with no significant changes observed in the CG. CONCLUSION: A 12-week mini-basketball intervention significantly enhanced multiple domains of EF in children with ADHD. These findings highlight the potential of cognitively engaging, sport-based exercise as an effective and feasible non-pharmacological strategy for improving executive function in this population. However, the relatively small sample size and reliance on parent-reported measures should be considered when interpreting the results. CI - Copyright (c) 2026 Cai, Liu, Zhu and Wen. FAU - Cai, Chengcheng AU - Cai C AD - Tennis Professional College, Wuhan City Polytechnic, Wuhan, China. FAU - Liu, Ruinan AU - Liu R AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, China. FAU - Zhu, Yingbo AU - Zhu Y AD - School of Physical Education and Sport, Henan University, Kaifeng, China. FAU - Wen, Zehui AU - Wen Z AD - School of Physical Education and Sport, Henan University, Kaifeng, China. LA - eng PT - Journal Article DEP - 20260521 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13233217 OTO - NOTNLM OT - ADHD OT - Mini-basketball OT - children OT - executive function OT - randomized controlled trial COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/05/21 CRDT- 2026/06/08 07:17 PHST- 2026/03/27 00:00 [received] PHST- 2026/04/22 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:17 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1840290 [doi] PST - epublish SO - Front Psychol. 2026 May 21;17:1840290. doi: 10.3389/fpsyg.2026.1840290. eCollection 2026. PMID- 42253594 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Association between parental support for physical activity and fundamental movement skills in children. PG - 1808648 LID - 10.3389/fpsyg.2026.1808648 [doi] LID - 1808648 AB - OBJECTIVE: To assess the level of fundamental movement skills (FMS) among children aged 6-10 years in Macau and to examine the associations between parental support for physical activity and children's FMS. METHODS: A total of 270 children aged 6-10 years were recruited, and 243 valid samples were included in the final analysis. Fundamental movement skills were assessed using the test of gross motor development, second edition (TGMD-2), and parental support was measured using the activity support scale for multiple groups (ACTS-MG). Descriptive statistics, independent samples t-tests, one-way ANOVA, and hierarchical multiple linear regression analyses were conducted to examine differences and associations. RESULTS: The mean total FMS score was 66.72, with locomotor skills outperforming object control skills across all age groups. FMS scores increased significantly with age (p < 0.01). Parental support levels were generally moderate to high, although parental modeling and community resource utilization showed relatively lower scores. Hierarchical regression analyses indicated that logistical support was significantly associated with locomotor skills (beta = 0.311, p < 0.01), object control skills (beta = 0.117, p < 0.05), and total FMS (beta = 0.288, p < 0.01), while community resource utilization was significantly associated with locomotor skills (beta = 0.253, p < 0.01) and total FMS (beta = 0.204, p < 0.05). CONCLUSION: Children aged 6-10 years in Macau demonstrated relatively low levels of fundamental movement skills and an imbalance in skill development, with locomotor skills outperforming object control skills. Parental logistical support and community resource utilization were positively associated with children's FMS, highlighting the importance of strengthening family support and improving community-based physical activity environments to promote balanced motor development in children. CI - Copyright (c) 2026 Zheng, Kong and Li. FAU - Zheng, Yijun AU - Zheng Y AD - Guangdong Pharmaceutical University, Guangzhou, Guangdong, China. FAU - Kong, Chuifeng AU - Kong C AD - School of Physical Education, Shanghai University of Sport, Shanghai, China. FAU - Li, Kai AU - Li K AD - College of Sports Industry and Leisure, Nanjing Sport Institute, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260521 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13233354 OTO - NOTNLM OT - Macau OT - children OT - fundamental movement skills OT - parental support OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2026/05/21 CRDT- 2026/06/08 07:17 PHST- 2026/02/11 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:17 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1808648 [doi] PST - epublish SO - Front Psychol. 2026 May 21;17:1808648. doi: 10.3389/fpsyg.2026.1808648. eCollection 2026. PMID- 42253219 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 1467-1107 (Electronic) IS - 1047-9511 (Print) IS - 1047-9511 (Linking) VI - 36 IP - 6 DP - 2026 Jun TI - Assessment of improvements in exercise tolerance following pulmonary valve replacement using physical accelerometry. PG - 1208-1214 LID - 10.1017/S1047951126113493 [doi] AB - BACKGROUND: Pulmonary valve replacement may be required for patients with pulmonary valve disease. Exertional symptoms related to cardiovascular disease are an indication for pulmonary valve replacement; however, quantification of symptom improvement postoperatively is challenging, and previous studies have yielded mixed data. Accelerometry has the potential to remotely monitor changes in exercise tolerance following pulmonary valve replacement. METHODS: Individuals (n = 18) age >13 years scheduled for catheter-based or surgical pulmonary valve replacement were prospectively enrolled. Participants were instructed to wear two Link GT9X accelerometers, placed on dominant wrist and one ankle, for seven days and nights before pulmonary valve replacement and again 3-6 months after the procedure. RESULTS: The cohort's median age was 26.5 [16.0, 35.0] years old. Compliance of both wrist and ankle accelerometers had a median of 96% or greater at both timepoints suggesting adequate participation. Accelerometry showed stability between participants. Quantitative analysis using pre-and post-pulmonary valve replacement accelerometer-derived measures yielded no significant differences. There was a significant decrease in the average score for items "Shortness of Breath with Strenuous Activity," "Extent Symptoms Impact Daily Activities," and "Challenges with Activities of Daily Living." Furthermore, all 9 individuals with baseline exertional intolerance had resolution of symptom in postoperative assessment. CONCLUSION: Reliability of accelerometer-derived activity measurements supports usage of physical accelerometry as a remote outcome measure to reduce patient burden for onsite assessment. Mixed qualitative versus quantitative improvement in physical activity tolerance observed in this study aligns with previous studies on variable improvement in exercise tolerance following pulmonary valve replacement. This discrepancy suggests the need for a different quantitative mechanism to measure benefit. FAU - Joy, Nicholas AU - Joy N AUID- ORCID: 0009-0005-1400-797X AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 FAU - Soslow, Jonathan H AU - Soslow JH AUID- ORCID: 0000-0001-9194-5330 AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 FAU - Crum, Kimberly AU - Crum K AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 FAU - Killian, Mary AU - Killian M AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 AD - Division of Pediatric Cardiology, Department of Pediatrics, University of Louisville School of Medicine, USA. FAU - Sunthankar, Sudeep AU - Sunthankar S AUID- ORCID: 0000-0002-2687-8204 AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 LA - eng GR - R01 HL167969/HL/NHLBI NIH HHS/United States GR - P50 HD106446/HD/NICHD NIH HHS/United States GR - R01 FD006649/FD/FDA HHS/United States GR - R56 HL141248/HL/NHLBI NIH HHS/United States GR - K23 HL123938/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260608 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM MH - Humans MH - *Exercise Tolerance/physiology MH - Female MH - Male MH - *Accelerometry/methods MH - *Heart Valve Prosthesis Implantation MH - *Pulmonary Valve/surgery MH - Adult MH - Prospective Studies MH - Adolescent MH - Young Adult PMC - PMC13311448 MID - NIHMS2175068 OTO - NOTNLM OT - accelerometry OT - exercise tolerance OT - pulmonary valve replacement OT - tetralogy of Fallot COIS- Dr Soslow has received a grant from Ametris, LLC. to conduct an observational study, however no associated data was used in development of this manuscript. EDAT- 2026/06/08 12:38 MHDA- 2026/10/20 17:34 PMCR- 2026/06/29 CRDT- 2026/06/08 06:43 PHST- 2026/10/20 17:34 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 06:43 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - S1047951126113493 [pii] AID - 10.1017/S1047951126113493 [doi] PST - ppublish SO - Cardiol Young. 2026 Jun;36(6):1208-1214. doi: 10.1017/S1047951126113493. Epub 2026 Jun 8. PMID- 42253078 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 1470-8752 (Electronic) IS - 0300-5127 (Print) IS - 0300-5127 (Linking) VI - 54 IP - 6 DP - 2026 Jun 24 TI - Fatty acid esters of hydroxy fatty acids and alkyl-diacylglycerols: minor but bioactive components in human milk. PG - 699-714 LID - 10.1042/BST20260825 [doi] AB - As the optimal source of nutrition for infants, investigations into the human milk lipidome have been quite extensive. Much of the work, however, has been focused on major lipid components such as triglycerides, possibly undermining its actual complexity. This review focuses on two minor but bioactive lipid classes in human milk: fatty acid esters of hydroxy fatty acids (FAHFAs) and alkyl-diacylglycerols (TG(O)s). FAHFAs are known to exhibit anti-diabetic and anti-inflammatory effects, while TG(O)s are important for the prevention of childhood obesity. With the knowledge that early nutrition and metabolic health influence the risk of metabolic dysfunctions later in life, a comprehensive understanding of FAHFAs and TG(O)s, along with reliable characterisations in human milk, would better allow for the development of accurate human milk fat substitutes. This could have future implications as alternative or preventive treatments for infants with early markers of metabolic dysfunction, including diabetes and obesity. The structural characteristics, pathways for biosynthesis and degradation, bioactivity, dietary sources, and characterisations of FAHFAs and TG(O)s in human milk are discussed. Their statuses as emerging lipid classes, however, is reflected in the incomplete understanding of their biochemical pathways. Characterisations of FAHFAs and TG(O)s in human milk are relatively poor, and contradicting results are reported. This review also addresses the challenges involved in the study of minor lipids in complex biological matrices, and the possible reasons underlying the slower evolution of our understanding of FAHFAs and TG(O)s in human milk and their associations with health outcomes. CI - (c) 2026 The Author(s). FAU - Lee, Megan Li Xian AU - Lee MLX AUID- ORCID: 0000-0002-4888-2845 AD - Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. AD - Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore. AD - Wilmar Innovation Center, Wilmar International HQ, Singapore 138568, Singapore. FAU - Elejalde, Untzizu AU - Elejalde U AUID- ORCID: 0009-0006-0035-3916 AD - Wilmar Innovation Center, Wilmar International HQ, Singapore 138568, Singapore. FAU - Cazenave-Gassiot, Amaury AU - Cazenave-Gassiot A AUID- ORCID: 0000-0002-3050-634X AD - Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore. AD - Department of Biochemistry and CVMD Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore. LA - eng GR - S22-10228-IPP-II-SI/Economic Development Board - Singapore (EDB)/ GR - S22-10228-IPP-II-SI/Wilmar International (Wilmar)/ PT - Journal Article PT - Review PL - England TA - Biochem Soc Trans JT - Biochemical Society transactions JID - 7506897 RN - 0 (Fatty Acids) RN - 0 (Esters) RN - 0 (Diglycerides) SB - IM MH - Humans MH - *Milk, Human/chemistry/metabolism MH - *Fatty Acids/chemistry/metabolism MH - *Esters/chemistry/metabolism MH - *Diglycerides/chemistry/metabolism PMC - PMC13259866 OTO - NOTNLM OT - Breast milk OT - FAHFA OT - TG(O) OT - ether lipids OT - lipids OT - obesity COIS- The authors declare that there are no competing interests associated with the manuscript. EDAT- 2026/06/08 06:36 MHDA- 2026/06/11 18:35 PMCR- 2026/06/08 CRDT- 2026/06/08 05:03 PHST- 2026/05/26 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/11 18:35 [medline] PHST- 2026/06/08 06:36 [pubmed] PHST- 2026/06/08 05:03 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 237666 [pii] AID - BST20260825 [pii] AID - 10.1042/BST20260825 [doi] PST - ppublish SO - Biochem Soc Trans. 2026 Jun 24;54(6):699-714. doi: 10.1042/BST20260825. PMID- 42253056 OWN - NLM STAT- MEDLINE DCOM- 20260608 LR - 20260813 IS - 1918-1523 (Electronic) IS - 1203-6765 (Print) IS - 1203-6765 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Prevalence and Determinants of Neck and Shoulder Pain Among Saudi Adults: A Cross-Sectional Study. PG - e9087950 LID - 10.1155/prm/9087950 [doi] LID - 9087950 AB - BACKGROUND: Neck and/or shoulder pain (NSP) represents a significant public health burden worldwide. However, nationally representative data from Saudi Arabia remain limited as most existing studies have focused on specific occupational groups or localized populations. This study examines the prevalence, determinants, and risk factors of NSP among Saudi adults. MATERIALS AND METHODS: A cross-sectional study was conducted between May and September 2024 among 2171 adults across Saudi Arabia. Data were collected from participants aged >/= 18 years using a structured, validated questionnaire assessing NSP prevalence, sociodemographic characteristics, lifestyle factors, and comorbidities. RESULT: Among 2171 participants (mean age of 29 +/- 12), 54% were females. The overall point prevalence of neck pain was 39.1%, while shoulder pain affected 38.6% of participants. Higher odds of neck pain were associated with use of electronic devices (OR = 1.82, p = 0.003), occupational tasks with extended standing (OR = 1.53, p = 0.003), and history of trauma (OR = 2.52, p < 0.001). Shoulder pain was associated with prolonged use of electronic devices (OR = 2.14, p < 0.001) and history of trauma (OR = 4.77, p < 0.001). Notably, regular exercise and male sex were protective against both neck pain and shoulder pain compared to females. CONCLUSION: NSP is common among Saudi adults and linked to modifiable lifestyle and work-related factors, underscoring the need for prevention, ergonomic measures, and regular pain management. Long-term studies are needed to evaluate its impact and treatment outcomes. CI - Copyright (c) 2026 Mohammad A. Jareebi et al. Pain Research and Management published by John Wiley & Sons Ltd. FAU - Jareebi, Mohammad A AU - Jareebi MA AUID- ORCID: 0000-0002-4525-1191 AD - Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Abutaleb, Yazeed Bader AU - Abutaleb YB AUID- ORCID: 0009-0006-7960-9354 AD - Department of Surgery, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Aldalbahi, Sultan Sayil Ghazi AU - Aldalbahi SSG AUID- ORCID: 0009-0009-1003-5681 AD - Department of Surgery, Faculty of Medicine, Shaqra University, Dawadmi, Saudi Arabia, su.edu.sa. FAU - Alharfi, Adel Ali AU - Alharfi AA AUID- ORCID: 0009-0002-7038-5519 AD - Department of Surgery, Faculty of Medicine, Tabuk University, Tabuk, Saudi Arabia, ut.edu.sa. FAU - Althobaiti, Faisal Mayudh AU - Althobaiti FM AUID- ORCID: 0009-0005-7379-5224 AD - Department of Surgery, Faculty of Medicine, Tabuk University, Tabuk, Saudi Arabia, ut.edu.sa. FAU - Barnawi, Lama Mohammad AU - Barnawi LM AD - Department of Surgery, Faculty of Medicine, Tabuk University, Tabuk, Saudi Arabia, ut.edu.sa. FAU - Alateeq, Noura Mohammed AU - Alateeq NM AUID- ORCID: 0009-0007-5642-4530 AD - Department of Surgery, Faculty of Medicine, Almaarefa University, Riyadh, Saudi Arabia, um.edu.sa. FAU - Alrabea, Hajer Othman AU - Alrabea HO AD - Department of Surgery, Faculty of Medicine, Almaarefa University, Riyadh, Saudi Arabia, um.edu.sa. FAU - Hakami, Ibrahim A AU - Hakami IA AUID- ORCID: 0000-0002-9795-477X AD - Department of Orthopedic Surgery, Dawadmi College of Medicine, Shaqra University, Shaqra, Saudi Arabia, su.edu.sa. FAU - Ryani, Majed A AU - Ryani MA AUID- ORCID: 0000-0003-1457-3064 AD - Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Bahri, Ahmed A AU - Bahri AA AUID- ORCID: 0000-0001-5849-6238 AD - Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Maslamani, Yahya A AU - Maslamani YA AUID- ORCID: 0000-0002-7241-7222 AD - Public Health Authority-Southern Sector, Jazan, Saudi Arabia. FAU - Masmali, Ali Abdullah AU - Masmali AA AD - Radiology Department, King Fahd Central Hospital, Jazan, Saudi Arabia. FAU - Aqeeli, Abdulwahab A AU - Aqeeli AA AUID- ORCID: 0000-0003-0841-6724 AD - Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Alasmari, Mohammed AU - Alasmari M AUID- ORCID: 0000-0002-5388-7579 AD - Orthopaedic Surgery Department, Majmaah University, Al Majma'ah, Saudi Arabia, mu.edu.sa. LA - eng PT - Journal Article PL - United States TA - Pain Res Manag JT - Pain research & management JID - 9612504 SB - IM MH - Humans MH - Female MH - Saudi Arabia/epidemiology MH - Cross-Sectional Studies MH - *Shoulder Pain/epidemiology MH - Prevalence MH - *Neck Pain/epidemiology MH - Male MH - Risk Factors MH - Adult MH - Young Adult MH - Middle Aged MH - Surveys and Questionnaires MH - Adolescent PMC - PMC13244136 OTO - NOTNLM OT - NSP prevalence OT - Saudi Arabia OT - electronic device use OT - neck pain OT - risk factors OT - shoulder pain COIS- The authors declare no conflicts of interest. EDAT- 2026/06/08 06:35 MHDA- 2026/06/08 19:38 PMCR- 2026/06/08 CRDT- 2026/06/08 05:03 PHST- 2026/03/24 00:00 [revised] PHST- 2025/08/07 00:00 [received] PHST- 2026/05/16 00:00 [accepted] PHST- 2026/06/08 19:38 [medline] PHST- 2026/06/08 06:35 [pubmed] PHST- 2026/06/08 05:03 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - PRM9087950 [pii] AID - 10.1155/prm/9087950 [doi] PST - ppublish SO - Pain Res Manag. 2026;2026(1):e9087950. doi: 10.1155/prm/9087950. PMID- 42252948 OWN - NLM STAT- Publisher LR - 20260608 IS - 0975-5764 (Electronic) IS - 0975-5764 (Linking) DP - 2026 Jun 5 TI - Surgical Management and Outcomes of Pediatric Gastrointestinal Bezoars Including Rapunzel Syndrome: A 9-year Single-center Case Series. LID - 10.4103/aam.aam_302_26 [doi] AB - BACKGROUND: Gastrointestinal bezoars are uncommon intraluminal masses frequently associated with psychiatric disorders in children. This study aimed to analyze the clinical characteristics, management strategies, and outcomes of pediatric bezoar cases at a tertiary care centre. MATERIALS AND METHODS: A retrospective analysis was conducted of all children aged /=96% and 8.3% GDM prevalence, PPV for GDM was 12.2% (95% CI 11.0-13.3%) for clinical factors alone, 26.5% (23.1-30.3%) for OGTT plus clinical factors, and 19.8% (17.2-22.5%) for CGM plus clinical factors. For LGA, neither glycemic model improved PPV. Validation confirmed findings. CONCLUSIONS: In a U.S.-representative population, adding 10- to 14-week OGTT or CGM criteria to clinical factors improved GDM but not LGA prediction. Future studies should determine whether predicting GDM in the first trimester facilitates interventions that improve GDM-related pregnancy outcomes. CI - (c) 2026 by the American Diabetes Association. CN - GO MOMs Study Group* LA - eng GR - U01 DK123783/DK/NIDDK NIH HHS/United States GR - U01 DK123759/DK/NIDDK NIH HHS/United States GR - U01 DK123745/DK/NIDDK NIH HHS/United States GR - U01DK123795/DK/NIDDK NIH HHS/United States GR - U01DK123791/DK/NIDDK NIH HHS/United States GR - U01DK123745/DK/NIDDK NIH HHS/United States GR - U01 DK123799/DK/NIDDK NIH HHS/United States GR - U01 DK123795/DK/NIDDK NIH HHS/United States GR - U01 DK123791/DK/NIDDK NIH HHS/United States GR - U01DK123783/DK/NIDDK NIH HHS/United States GR - U01DK123759/DK/NIDDK NIH HHS/United States GR - U01DK123799/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Observational Study PL - United States TA - Diabetes Care JT - Diabetes care JID - 7805975 RN - 0 (Blood Glucose) SB - IM CIN - Diabetes Care. 2026 Oct 1;49(10):1768-1770. doi: 10.2337/dci26-0079. PMID: 42766766 MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/diagnosis/blood MH - Infant, Large for Gestational Age MH - Glucose Tolerance Test MH - Adult MH - Continuous Glucose Monitoring MH - Blood Glucose/metabolism MH - Prospective Studies MH - *Birth Weight/physiology MH - Infant, Newborn PMC - PMC13594796 COIS- Duality of Interest. C.E.P. reported receiving speaker fees and honoraria from Mediflix and Medscape, speaker fees from the Endocrine Society, royalties from Wolters Kluwer/UpToDate, honoraria from the American Diabetes Association, and research funding to her institution from Dexcom. No other potential conflicts of interest relevant to this article were reported. FIR - Scholtens, Denise IR - Scholtens D FIR - Siddique, Juned IR - Siddique J FIR - Bustamante, Patricia IR - Bustamante P FIR - Cheung, Ying Jennifer IR - Cheung YJ FIR - Grott, Tania IR - Grott T FIR - Kuang, Alan IR - Kuang A FIR - Banker, Margaret IR - Banker M FIR - Tull, Mary Beth IR - Tull MB FIR - Guachichullca, Jessica IR - Guachichullca J EDAT- 2026/06/07 18:43 MHDA- 2026/09/21 17:47 PMCR- 2026/06/07 CRDT- 2026/06/07 17:33 PHST- 2026/02/06 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/06/07 18:43 [pubmed] PHST- 2026/06/07 17:33 [entrez] PHST- 2026/06/07 00:00 [pmc-release] AID - 170064 [pii] AID - 260302 [pii] AID - 10.2337/dc26-0302 [doi] PST - ppublish SO - Diabetes Care. 2026 Oct 1;49(10):1779-1789. doi: 10.2337/dc26-0302. PMID- 42251728 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 2057-4347 (Electronic) IS - 2057-4347 (Linking) VI - 12 IP - 3 DP - 2026 Jun TI - Applying Automated Artificial Intelligence Models on Lateral Cephalometric Parameters to Accurately Classify Arab Orthodontic Patient Patterns. PG - e70372 LID - 10.1002/cre2.70372 [doi] LID - e70372 AB - OBJECTIVES: Malocclusion and the treatment process can affect the person's quality of life, which includes physical and psychological effects. Classifying the patient accurately is critical to achieving the desired output. This study aimed to improve the current diagnostic process with artificial-intelligence algorithms using the lateral cephalogram. MATERIALS AND METHODS: The study sample consisted of 1014 Arab patients diagnosed with skeletal class I, II, or III. In this study, we used linear discriminant analysis (LDA), random forest (RF), decision tree (DT), K-nearest neighbors (KNN), support vector machine (SVM), and naive Bayes (NB) as classification models. In addition, we calculated the parameters' importance using two techniques-the impurity decreases and the leave-one-feature-out (LOFO) technique. Finally, we applied an artificial neural network (ANN) to classify the patients accurately. RESULTS: One of the influential models presented in this study was the model that included only the parameters Wits appraisal, SNB, SNA, and ML-NSL angles. It could classify the patients with an accuracy of 0.98. In addition, we applied the leave-one-feature-out technique (LOFO) for multiple random forest models and found that the Calculated_ANB (ANB angle-individualized ANB) and Wits appraisal were the most important parameters in the random forest models. Besides, age and gender were in 8th and 21st places (out of 26 variables). Furthermore, the decision tree results demonstrated the distinct characteristics of this ethnic group, which were presented by different ranges of ANB angles that define every skeletal class. The results showed that the tree's root classified the patient as skeletal class III when the ANB angle is less than 0.084 degrees, and skeletal class II if the ANB angle is greater than 1.23. CONCLUSIONS: In summary, this research presented a model enabling orthodontists to precisely classify orthodontic patients. Further research should include different ethnic groups to validate our findings. CI - (c) 2026 The Author(s). Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. FAU - Midlej, Kareem AU - Midlej K AD - Department of Clinical Microbiology and Immunology, Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Proff, Peter AU - Proff P AD - Department of Orthodontics, University Hospital of Regensburg, University of Regensburg, Regensburg, Germany. FAU - Watted, Nezar AU - Watted N AD - Center for Dentistry Research and Aesthetics, Jatt, Israel. AD - Department of Orthodontics, Faculty of Dentistry, Arab American University, Jenin, Palestine. FAU - Iraqi, Fuad A AU - Iraqi FA AUID- ORCID: 0000-0001-5525-206X AD - Department of Clinical Microbiology and Immunology, Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel. AD - Department of Orthodontics, University Hospital of Regensburg, University of Regensburg, Regensburg, Germany. LA - eng GR - Tel Aviv University, Israel/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Exp Dent Res JT - Clinical and experimental dental research JID - 101692332 SB - IM MH - Humans MH - *Cephalometry/methods MH - Female MH - *Malocclusion/diagnosis/classification MH - Random Forest MH - Male MH - Classification Algorithms MH - Arabs MH - Decision Trees MH - *Artificial Intelligence MH - Discriminant Analysis MH - Neural Networks, Computer MH - Adolescent MH - Bayes Theorem MH - Support Vector Machine MH - Child MH - Algorithms PMC - PMC13242863 OTO - NOTNLM OT - cephalometric parameters OT - deep-learning OT - diagnosis OT - machine-learning OT - personalized medicine OT - skeletal malocclusion COIS- The authors declare no conflicts of interest. EDAT- 2026/06/07 18:41 MHDA- 2026/06/11 06:37 PMCR- 2026/06/07 CRDT- 2026/06/07 14:22 PHST- 2026/03/26 00:00 [revised] PHST- 2025/11/17 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/06/11 06:37 [medline] PHST- 2026/06/07 18:41 [pubmed] PHST- 2026/06/07 14:22 [entrez] PHST- 2026/06/07 00:00 [pmc-release] AID - CRE270372 [pii] AID - 10.1002/cre2.70372 [doi] PST - ppublish SO - Clin Exp Dent Res. 2026 Jun;12(3):e70372. doi: 10.1002/cre2.70372. PMID- 42251514 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260611 IS - 0975-4466 (Electronic) IS - 0256-4947 (Linking) VI - 46 IP - 3 DP - 2026 May-Jun TI - Establishment and validation of reference intervals for the neutrophil CD64 index in a healthy adult population from Guangxi, China. PG - 216-224 LID - 10.5144/0256-4947.2026.216 [doi] AB - BACKGROUND: The neutrophil CD64 (nCD64) index is a potent biomarker for infectious diseases; however, the lack of standardized reference intervals (RIs) limits its clinical utility. OBJECTIVES: This study aimed to establish and validate reference intervals (RIs) for the nCD64 index specifically for the Guangxi population using flow cytometry. DESIGN: Cross-sectional study. SETTINGS: Conducted in Guangxi, China. PATIENTS AND METHODS: A total of 494 healthy adults (aged 18-83 years) were enrolled. Peripheral blood nCD64 expression was measured via flow cytometry. Reference intervals were determined using the non-parametric 95th percentile method (2.5th-97.5th) per CLSI EP28-A3c guidelines. Validation was performed in an independent cohort (n=30). MAIN OUTCOME MEASURES: The primary outcome was the 95% reference interval for the nCD64 index. Secondary outcomes included correlations between nCD64 index and sex, age, BMI, and primary hematological parameters. SAMPLE SIZE: 494 healthy adults for establishment, plus 30 independent subjects for validation. RESULTS: No clinically significant differences in the nCD64 index were found between sexes or across age groups, and partitioning was not required. The nCD64 index exhibited a skewed distribution. Although sex showed a weak positive correlation with nCD64 expression (r=.115, P=.011), the standard normal deviation test (z/= 2) posture saw a 1.76 +/- 2.9 mm and 3.29 +/- 6.5 mm decrease in RMS and MaxDev, respectively. In contrast, RMS and MaxDev increased by 1.03 +/- 3.0 mm and 1.26 +/- 5.6 mm, respectively, among individuals who stated that their posture had deteriorated or not changed (GRC < 2). Using ROC analysis, MCICs for RMS and MaxDev were determined to be -0.27 mm (area under the curve (AUC) 0.746, sensitivity 67%, specificity 74%) and - 0.49 mm (AUC 0.717, sensitivity 64%, specificity 68%), respectively, for overall improvement perception. Having met both thresholds reduced sensitivity to 62% and achieved 74% specificity. MCICs for thoracic curve types were - 0.58 mm (AUC 0.618, sensitivity 60%, specificity 53%) for RMS and - 1.32 mm (AUC 0.632, sensitivity 73%, specificity 92%) for MaxDev. MCICs for lumbar curve types were - 0.26 mm for RMS (AUC 0.881, sensitivity 73%, specificity 92%) and - 0.61 mm for MaxDev (AUC 0.811, sensitivity 68%, specificity 83%). CONCLUSION: Changes in RMS and MaxDev were aligned to GRC score reflecting perceived improvements in back condition. Stronger associations were observed between ST parameters and perceived improvement in lumbar than thoracic or combining all curves. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Mohamed, Nada AU - Mohamed N AD - Department of Mechanical Engineering, University of Alberta, Edmonton, Canada. FAU - Gonzalez Ruiz, Jose Maria AU - Gonzalez Ruiz JM AD - Department of Mechanical Engineering, University of Alberta, Edmonton, Canada. josemar1@ualberta.ca. AD - 3D-Data Department, Society for the Advancement of Applied Computer Science, Berlin, Germany. josemar1@ualberta.ca. FAU - Schreiber, Sanja AU - Schreiber S AD - Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada. FAU - Parent, Eric AU - Parent E AD - Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada. FAU - Mei, Qipei AU - Mei Q AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Canada. FAU - Westover, Lindsey AU - Westover L AD - Department of Mechanical Engineering, University of Alberta, Edmonton, Canada. LA - eng PT - Journal Article DEP - 20260606 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Patient-reported outcome measures OT - Postural asymmetry OT - Schroth exercises OT - Surface topography COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/06 12:34 MHDA- 2026/06/06 12:34 CRDT- 2026/06/06 11:03 PHST- 2025/10/24 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/06 12:34 [medline] PHST- 2026/06/06 12:34 [pubmed] PHST- 2026/06/06 11:03 [entrez] AID - 10.1007/s00586-026-10071-7 [pii] AID - 10.1007/s00586-026-10071-7 [doi] PST - aheadofprint SO - Eur Spine J. 2026 Jun 6. doi: 10.1007/s00586-026-10071-7. PMID- 42249465 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260902 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 Jun 5 TI - Remote, bivariate prior elicitation for a Bayesian non-inferiority randomized controlled trial. LID - 10.1186/s13063-026-09828-8 [doi] LID - 520 AB - BACKGROUND: Prior distributions must be specified for the parameters of interest in a Bayesian clinical trial. When existing evidence on the effects of the trial interventions is limited or inconclusive, prior distributions can be constructed with expert elicitation. However, conventional elicitation requires face-to-face interactions and intensive pre-elicitation training, which can be infeasible and costly. Our remote elicitation was based on an established expert elicitation methodology, and we incorporated bivariate prior distributions to introduce dependencies between the elicited probabilities. We aimed to elicit a prior distribution for the Croup Dosing Trial, which assesses the efficacy of two separate doses of dexamethasone on the number of return visits to the emergency department within 7 days in children with croup. This trial evaluates the non-inferiority of 0.15 mg/kg of dexamethasone, compared to the standard dose of 0.60 mg/kg to treat croup. METHODS: We conducted three remote workshops to elicit expert beliefs on the efficacy of the two doses of dexamethasone. Each workshop consisted of two survey rounds, separated by a group discussion. Prior to the workshop, experts reviewed the same current literature that was provided on the effects of the two doses of dexamethasone. Beliefs were aggregated using expert-specific bivariate distributions with latent effects. The aggregated distribution, along with the surveyed non-inferiority margin, determined the sample size for the Bayesian non-inferiority trial design. RESULTS: Twelve emergency medicine physicians participated in our remote elicitation exercise. The elicitation generated a prior distribution centered at 6% for the 0.60 mg/kg dose and 8% for the 0.15 mg/kg dose. The aggregated prior distribution produced a sample size of 1850, based on a non-inferiority margin of 4%. CONCLUSIONS: We elicited a prior distribution that incorporated past evidence and expert opinion. The elicited prior is consistent with previous literature on the efficacy of the dexamethasone doses in treating croup. Our approach demonstrates the feasibility of remotely eliciting bivariate distributions to design clinical trials. TRIAL REGISTRATION: NCT06272383 (Registered May 8, 2024). CI - (c) 2026. The Author(s). FAU - Jiang, Arlene AU - Jiang A AUID- ORCID: 0009-0000-3158-8650 AD - Child Health Evaluative Sciences, The Hospital for Sick Children, 686 Bay Street, Toronto, ON, M5G 0A4, Canada. arlene.jiang@sickkids.ca. FAU - Aregbesola, Alex AU - Aregbesola A AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Gangwani, Apoorva AU - Gangwani A AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Klassen, Terry P AU - Klassen TP AD - College of Medicine, University of Saskatchewan and Jim Pattison Children's Hospital, Saskatchewan Health Authority, Saskatoon, SK, Canada. FAU - Plint, Amy C AU - Plint AC AD - Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada. AD - Division of Emergency Medicine, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Doyle, Elisabete AU - Doyle E AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Craig, William AU - Craig W AD - Department of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. FAU - Eltorki, Mohamed AU - Eltorki M AD - Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Oketola, Banke AU - Oketola B AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Badran, Hoda AU - Badran H AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Ouyang, Yongdong AU - Ouyang Y AD - Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. FAU - Heath, Anna AU - Heath A AD - Child Health Evaluative Sciences, The Hospital for Sick Children, 686 Bay Street, Toronto, ON, M5G 0A4, Canada. AD - Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Department of Statistical Science, University College London, London, UK. LA - eng SI - ClinicalTrials.gov/NCT06272383 GR - RGPIN-2021-03366/Canada Research Chairs/ GR - 2024 New Investigator Operating Grant #6456/Research Manitoba/ PT - Clinical Trial, Phase III PT - Equivalence Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20260605 PL - England TA - Trials JT - Trials JID - 101263253 RN - 7S5I7G3JQL (Dexamethasone) RN - 0 (Glucocorticoids) SB - IM MH - Child MH - Humans MH - Bayes Theorem MH - *Croup/drug therapy/diagnosis MH - *Dexamethasone/administration & dosage/adverse effects MH - Emergency Service, Hospital MH - *Glucocorticoids/administration & dosage/adverse effects MH - *Research Design MH - Time Factors MH - Treatment Outcome PMC - PMC13459373 OTO - NOTNLM OT - Bayesian statistics OT - Expert elicitation OT - Non-inferiority trial OT - Prior probability distribution OT - Randomized controlled trials OT - Sample size determination OT - Trial design COIS- Declarations. Ethics approval and consent to participate: The elicitation of the Croup Dosing Trial has ethics approval from Health Canada (# CDS0923) as well as University of Manitoba Health Research Ethics Board & Shared Health (# HS26166 (B2023:092)) approval. The Hospital for Sick Children Research Ethics Board approved a secondary use of the elicitation data (# 1000081720). Implied consent was used in this study. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/06/06 00:35 MHDA- 2026/08/11 06:36 PMCR- 2026/06/05 CRDT- 2026/06/05 23:38 PHST- 2024/11/15 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/08/11 06:36 [medline] PHST- 2026/06/06 00:35 [pubmed] PHST- 2026/06/05 23:38 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - 10.1186/s13063-026-09828-8 [pii] AID - 9828 [pii] AID - 10.1186/s13063-026-09828-8 [doi] PST - epublish SO - Trials. 2026 Jun 5;27(1):520. doi: 10.1186/s13063-026-09828-8. PMID- 42248933 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260820 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 5 TI - Evaluating chest-worn light logger adherence: development and application of a wear/non-wear model. LID - 10.1038/s41598-026-54493-1 [doi] LID - 25733 AB - Light exposure plays an important role in overall health because it entrains circadian rhythms. Recent technological advances in wearable light loggers allow measurement daily light exposure habits. Using a chest-worn light logger, our goal was to (1) develop methodology for differentiating adherent versus non-adherent use, and (2) define differences in lighting intensity in indoor and outdoor environments, to improve data reliability in future clinical studies using this technology. Four testers used a 10-channel chest worn light logging device under different conditions of wear and non-wear (experiment 1), and another tester made measurements with the light logger across a variety of indoor and outdoor lighting environments (experiment 2). In experiment 1, measurements from the light logger (photopic illuminance, device orientation, accelerometer data, time of day) were used to train models to differentiate wear from non-wear and correct nighttime placement. The most accurate model was then tested with the remaining data from testers (T1 - T4). This model was then applied to 20 adolescents and young adults with migraine who wore the light logger device for one week. In experiment 2, measurements of photopic illuminance and melanopic equivalent daytime illuminance (mEDI) of darker indoor versus brighter outdoor lighting environments were compared to identify the optimal indoor/outdoor distinction point for the chest-worn light logger. Movement, device orientation, light, and time-of-day used as predictors in a random forest model had excellent differentiation between wear, non-wear and nighttime use (overall accuracy 0.95), and retained good-to-excellent differentiation when applied to the test dataset (overall accuracy 0.76). When this model was applied to 20 participants with migraine, we found that 92.1% of participant-days and 77.9% of participant-nights demonstrated at least 80% appropriate use. Applying the wear/non-wear model to this dataset led to modest changes in light exposure measurements but did not change conclusions of our prior study. For differentiating indoor and outdoor lighting environments, the optimal cut-point was 442 lx for photopic illuminance, and 412 lx for mEDI. We demonstrate that internal measurements from a chest-worn light logging device can reliably differentiate wear from non-wear. We also found that the optimal cut-off to differentiate indoor and outdoor lighting environments was lower than 1,000 lx cut-offs traditionally used to define bright light conditions. These findings can be used to improve data reliability in studies of everyday light exposure in clinical populations using chest-worn light loggers. CI - (c) 2026. The Author(s). FAU - Patterson Gentile, Carlyn AU - Patterson Gentile C AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. pattersonc@chop.edu. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. pattersonc@chop.edu. FAU - Thomas, Adah AU - Thomas A AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Shah, Ryan AU - Shah R AD - Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA. FAU - Marquez De Prado, Blanca AU - Marquez De Prado B AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Raj, Nichelle AU - Raj N AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Szperka, Christina L AU - Szperka CL AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Aguirre, Geoffrey K AU - Aguirre GK AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. LA - eng GR - K23 NS124986/NS/NINDS NIH HHS/United States GR - R25 HD101365/HD/NICHD NIH HHS/United States GR - Foerderer/Children's Hospital of Philadelphia/ GR - R01EY036255/EY/NEI NIH HHS/United States GR - R25HD101365/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - R01 EY036255/EY/NEI NIH HHS/United States GR - K23NS124986/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20260605 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM UOF - medRxiv. 2025 Sep 30:2025.09.29.25336898. doi: 10.1101/2025.09.29.25336898. PMID: 41256166 MH - Humans MH - *Lighting MH - Adolescent MH - *Light MH - Circadian Rhythm/physiology MH - *Wearable Electronic Devices MH - Male MH - Young Adult MH - Female MH - *Patient Compliance MH - Adult PMC - PMC13482094 OTO - NOTNLM OT - Continuous light measurements OT - Daily light exposure OT - Data reliability OT - Melanopic equivalent daylight illuminance OT - Photopic illuminance COIS- Declarations. Conflict of interest: Commercial Relationships Disclosures: C.P.G.: Dr. Patterson Gentile is currently funded by the National Institutes of Health/National Institute of Neurological Disorders and Stroke (K23 NS124986). C.L.S.: Dr. Szperka has received research/grant support from the PCORI. Dr. Szperka or her institution have received compensation for her consulting work for Eli Lilly; Teva Pharmaceutical Industries Ltd; Upsher-Smith Laboratories, LLC; Abbvie; and Lundbeck. Dr. Szperka has intellectual property as the inventor of the text-based headache diary used in the study. She did not receive any financial compensation related to this paper. G.K.A.: Dr. Aguirre receives funding/grant support from the National Institute of Neurological Disorders and Stroke, the National Eye Institute, and the Binational Science Foundation. A.T., R.S., B.M.P., and N.R. do not have conflicts of interest. EDAT- 2026/06/06 00:35 MHDA- 2026/08/18 07:46 PMCR- 2026/06/05 CRDT- 2026/06/05 23:17 PHST- 2025/10/07 00:00 [received] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/08/18 07:46 [medline] PHST- 2026/06/06 00:35 [pubmed] PHST- 2026/06/05 23:17 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - 10.1038/s41598-026-54493-1 [pii] AID - 54493 [pii] AID - 10.1038/s41598-026-54493-1 [doi] PST - epublish SO - Sci Rep. 2026 Jun 5;16(1):25733. doi: 10.1038/s41598-026-54493-1. PMID- 42247777 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1878-0539 (Electronic) IS - 1748-6815 (Linking) VI - 118 DP - 2026 Jul TI - Quantitative preliminary indication criteria and clinical outcomes of Abbe Flap repair for secondary cleft lip deformities. PG - 313-324 LID - S1748-6815(26)00316-5 [pii] LID - 10.1016/j.bjps.2026.05.050 [doi] AB - OBJECTIVE: Secondary nasolabial deformities are common after primary cleft lip repair, yet objective preliminary quantitative indication criteria for Abbe flap repair remain lacking. This study aimed to establish preliminary quantitative indication thresholds for Abbe flap repair, evaluate its clinical efficacy, and explore preoperative predictors for optimal postoperative outcomes. METHODS: This STROBE-compliant retrospective cohort study enrolled 102 patients with secondary cleft lip deformities (21 in Abbe flap group, 81 in non-Abbe flap group) and 36 healthy controls. Standardized anthropometric measurements, phenotypic stratification via cluster analysis, and ROC curve analysis for diagnostic efficacy were conducted. RESULTS: The Abbe flap group showed significant postoperative improvements in all core morphological parameters (all P < 0.05), while conventional non-Abbe repair yielded minimal improvement in patients with significant upper lip tissue deficiency. The optimal preliminary cut-off values for Abbe flap indication were upper-to-lower lip projection ratio (ULR) /=108 degrees (sensitivity 95.24%, specificity 93.15%). Stratified analysis confirmed the therapeutic superiority of Abbe flap was independent of initial cleft type, and preoperative lip height index (LHI) and intercanthal width to medial upper lip height ratio (IMWH) were independent predictors for optimal postoperative outcomes. CONCLUSION: Preoperative ULR /=108 degrees can be used as preliminary objective quantitative reference criteria for Abbe flap selection in secondary cleft lip deformity patients, with prospective multi-center validation required for further clinical generalization. The Abbe flap can achieve significant correction of morphological abnormalities caused by upper lip tissue deficiency, and preoperative LHI and IMWH can assist in prognostic evaluation for surgical candidates. CI - Copyright (c) 2026 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - He, Wen AU - He W AD - Department of Burn and Plastic Surgery, Children's Hospital of Chongqing Medical University, No. 136 Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China. Electronic address: 1738591282@qq.com. FAU - Qiu, Lin AU - Qiu L AD - Department of Burn and Plastic Surgery, Children's Hospital of Chongqing Medical University, No. 136 Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China. LA - eng PT - Journal Article DEP - 20260529 PL - Netherlands TA - J Plast Reconstr Aesthet Surg JT - Journal of plastic, reconstructive & aesthetic surgery : JPRAS JID - 101264239 SB - IM MH - Humans MH - *Cleft Lip/surgery MH - *Surgical Flaps MH - Female MH - Retrospective Studies MH - Male MH - Treatment Outcome MH - *Plastic Surgery Procedures/methods MH - Child MH - Child, Preschool MH - Lip/surgery MH - Adolescent MH - Infant OTO - NOTNLM OT - Abbe flap OT - Anthropometric measurement OT - Quantitative indication OT - Secondary cleft lip deformity OT - Surgical outcome COIS- Declaration of Competing Interest None declared. EDAT- 2026/06/06 00:34 MHDA- 2026/06/27 00:53 CRDT- 2026/06/05 18:03 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/27 00:53 [medline] PHST- 2026/06/06 00:34 [pubmed] PHST- 2026/06/05 18:03 [entrez] AID - S1748-6815(26)00316-5 [pii] AID - 10.1016/j.bjps.2026.05.050 [doi] PST - ppublish SO - J Plast Reconstr Aesthet Surg. 2026 Jul;118:313-324. doi: 10.1016/j.bjps.2026.05.050. Epub 2026 May 29. PMID- 42247677 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260911 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 Jun 5 TI - Automated Physical Activity Support for Adults and Youth From Low-Income Communities: Single-Arm Pilot Study. PG - e76991 LID - 10.2196/76991 [doi] LID - e76991 AB - BACKGROUND: Mobile health (mHealth) interventions are growing in popularity, but less research has focused on low-income families, particularly interventions integrating wearable devices with automated personalized messages. OBJECTIVE: We tested a preliminary wearable-integrated mHealth intervention with initial personalization elements among adults and youth from low-income urban communities, focusing on feasibility, acceptability, and preliminary evidence of physical activity behavior. METHODS: Participants were 83 adults and 31 youth recruited through community health events held in low-income urban communities. Using a single-arm pre-post design, participants were enrolled into a 7-week beta-version mHealth intervention that integrated a Garmin activity monitor with automated text messages. Messages were sent 4 days/week and focused on increasing step counts using theory-based behavior change techniques related to goal setting, self-monitoring, reinforcement, contextual factors, and self-efficacy. Most messages were personalized by including calculations based on the step-count and step-goal data, using branching logic, and using 2-way question-and-response messages. Feasibility measures included enrollment, retention, fidelity of message delivery, and adherence to wearing the Garmin device. Acceptability measures included survey items and engagement with responding to 2-way messages. Changes in daily steps were explored using mixed-effects linear regression. RESULTS: Enrollment and eligibility rates were 64% (84/132, adults) and 63% (31/49, youth), retention for physical activity measures was 84% (70/83) and 77% (24/31), and 99% (3910/3955) of the intended messages were delivered. Adults and youth adhered to wearing the Garmin on 82% (45/56) and 79% (44/56) of the study days, respectively. Overall acceptability ratings were 83% to 100%, with 97% (75/77) of adults and 100% (27/27) of youth indicating they would recommend the program. Adults and youth replied to a mean of 2.6 (SD 2.2) and 3.2 (SD 2.7) of the 7 text messages that asked for a reply, with higher engagement among adults who participated with their child. Pre-post changes in daily steps were beta=240 (95% CI -387 to 866) for adults and beta=413 (95% CI -877 to 1703) among youth, with larger changes observed among those in the highest tertile of engagement (adults: beta=584, 95% CI -784 to 1952; n=19; youth: beta=941, 95% CI -827 to 2709; n=11) and those who were meeting less than two-thirds of the physical activity guideline at baseline (adults: beta=609, 95% CI -30 to 1247; n=47; youth: beta=1406, 95% CI -94 to 2907; n=22). CONCLUSIONS: Personalized mHealth physical activity interventions integrating wearable step trackers with automated text messaging appear to be feasible and acceptable among adults and youth from low-income communities. Step-count findings show promise for the intervention's ability to support individuals who are further from meeting physical activity guidelines and warrant more research among parent-child dyads. Overall, findings support additional research to optimize and evaluate similar interventions within this population group using fully powered randomized controlled trials. TRIAL REGISTRATION: ClinicalTrials.gov NCT05110508; https://clinicaltrials.gov/ct2/show/NCT05110508. CI - (c)Jordan A Carlson, Frank Materia, Mallory Moon, Suryeon Ryu, Cory Yeager, Chelsea Steel, Kacee Shields, Harpreet Singh Gill, Jannette Berkley-Patton, Delwyn Catley. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 05.06.2026. FAU - Carlson, Jordan A AU - Carlson JA AUID- ORCID: 0000-0002-6008-7983 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Materia, Frank AU - Materia F AUID- ORCID: 0000-0002-8015-1743 AD - Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, KS, United States. AD - Department of Population Health, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Moon, Mallory AU - Moon M AUID- ORCID: 0009-0008-3332-7049 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Ryu, Suryeon AU - Ryu S AUID- ORCID: 0000-0002-8080-8821 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Yeager, Cory AU - Yeager C AUID- ORCID: 0009-0005-9273-9519 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Steel, Chelsea AU - Steel C AUID- ORCID: 0000-0002-7119-5840 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Shields, Kacee AU - Shields K AUID- ORCID: 0009-0006-9302-3093 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Gill, Harpreet Singh AU - Gill HS AUID- ORCID: 0009-0001-9512-7615 AD - Research Informatics, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Berkley-Patton, Jannette AU - Berkley-Patton J AUID- ORCID: 0000-0003-0235-7057 AD - Department of Biomedical and Health Informatics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, United States. FAU - Catley, Delwyn AU - Catley D AUID- ORCID: 0000-0002-7270-8732 AD - Department of Psychology, San Diego State University, San Diego, CA, United States. LA - eng SI - ClinicalTrials.gov/NCT05110508 PT - Journal Article DEP - 20260605 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - Pilot Projects MH - Female MH - *Poverty/statistics & numerical data/psychology MH - Adult MH - Male MH - *Exercise/psychology MH - Adolescent MH - Middle Aged MH - Digital Health MH - Text Messaging/instrumentation/statistics & numerical data MH - Telemedicine/instrumentation MH - Wearable Electronic Devices/statistics & numerical data/standards PMC - PMC13282599 OTO - NOTNLM OT - African American OT - community engagement OT - medically underserved OT - text messaging OT - wearables COIS- Conflicts of Interest: None declared. EDAT- 2026/06/05 18:36 MHDA- 2026/06/11 06:39 PMCR- 2026/06/05 CRDT- 2026/06/05 16:53 PHST- 2025/05/20 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/05/07 00:00 [revised] PHST- 2026/06/11 06:39 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 16:53 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - v14i1e76991 [pii] AID - 10.2196/76991 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Jun 5;14:e76991. doi: 10.2196/76991. PMID- 42247675 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260908 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jun 5 TI - Evaluating the Effectiveness of the School-Based Sustainable Innovation for Children Transporting Actively Intervention: Protocol for an Age-Cohort Study. PG - e92946 LID - 10.2196/92946 [doi] LID - e92946 AB - BACKGROUND: Few children achieve the recommended daily levels of physical activity. Active school transportation (AST) offers a valuable opportunity to increase children's physical activity. Initiatives promoting AST in early childhood are important and have the potential to reverse the decline in physical activity. OBJECTIVE: This study protocol outlines an age-cohort design to evaluate the effectiveness of the Sustainable Innovation for Children Transporting Actively (SICTA) intervention on children's AST. METHODS: SICTA is a 4-week school-based intervention that incorporates gamification elements to enhance motivation and aims to increase AST in children. The intervention involves children and their parents as gatekeepers, as well as teachers delivering the intervention. All children, parents, and teachers in all schools, from grades 4 to 6 in one municipality in the southern part of Sweden, will be invited to participate in the evaluation. Following the age-cohort design, students at baseline (late fall 2024) will be compared with students of the same age from the same schools 1 year later at follow-up (late fall 2025) after receiving the intervention (implemented in late fall 2025). Using questionnaires at baseline and follow-up, this study will examine the effects of the intervention on children's levels of AST. Children's independent mobility and several mediators related to AST in both children and parents, based on the theory of planned behavior, the transtheoretical model of change, and self-determination theory, will also be examined. The intervention will also be evaluated from a sustainable perspective using the sustainable value equation. At follow-up, data collection will include a questionnaire for teachers assessing the feasibility of the intervention. RESULTS: The project is funded for the period 2024-2026, and follow-up data collection is ongoing following completion of the intervention in late fall 2025. Results will be reported according to the predefined outcomes, including changes in AST, children's independent mobility, psychosocial determinants among children and parents, and sustainability outcomes, as well as feasibility. CONCLUSIONS: The findings are expected to provide valuable insights into the effectiveness of the SICTA intervention, facilitating knowledge dissemination among end users and policymakers. TRIAL REGISTRATION: Swedish National Research Database Researchweb.org 283668; https://tinyurl.com/496rc6r4. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/92946. CI - (c)Hanna Forsberg, Anna-Karin Lindqvist, Stina Rutberg, Palma Chillon, Veronica Sjoberg, Annie Palstam. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 05.06.2026. FAU - Forsberg, Hanna AU - Forsberg H AUID- ORCID: 0000-0002-1239-9675 AD - Department of Health, Education and Technology, Lulea University of Technology, Lulea, Norrbotten, Sweden. FAU - Lindqvist, Anna-Karin AU - Lindqvist AK AUID- ORCID: 0000-0003-3145-7698 AD - Department of Health, Education and Technology, Lulea University of Technology, Lulea, Norrbotten, Sweden. FAU - Rutberg, Stina AU - Rutberg S AUID- ORCID: 0000-0001-9376-6053 AD - Department of Health, Education and Technology, Lulea University of Technology, Lulea, Norrbotten, Sweden. FAU - Chillon, Palma AU - Chillon P AUID- ORCID: 0000-0003-0862-8989 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), Universidad de Granada, Granada, Andalusia, Spain. FAU - Sjoberg, Veronica AU - Sjoberg V AUID- ORCID: 0000-0002-3843-0407 AD - School of Health and Welfare, Dalarna University, Falun, Dalarna, Sweden. FAU - Palstam, Annie AU - Palstam A AUID- ORCID: 0000-0002-7127-213X AD - School of Health and Welfare, Dalarna University, Falun, Dalarna, Sweden. AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Shalgrenska Academy, University of Gothenburg, Gothenburg, Vastra Gotaland, Sweden. AD - Rehabilitation Medicine, Sahlgrenska University Hospital, Gothenburg, Vastra Gotaland, Sweden. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260605 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Sweden MH - *Transportation/methods/standards MH - Child MH - Cohort Studies MH - Schools MH - *Exercise/psychology MH - Surveys and Questionnaires MH - Female MH - Male MH - Program Evaluation/methods MH - Research Design MH - Students/statistics & numerical data/psychology MH - *Health Promotion/methods PMC - PMC13282597 OTO - NOTNLM OT - active commuting OT - age cohort OT - feasibility OT - physical activity OT - sustainability COIS- Conflicts of Interest: None declared. EDAT- 2026/06/05 18:36 MHDA- 2026/06/11 18:35 PMCR- 2026/06/05 CRDT- 2026/06/05 16:52 PHST- 2026/02/14 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/04/25 00:00 [revised] PHST- 2026/06/11 18:35 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 16:52 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - v15i1e92946 [pii] AID - 10.2196/92946 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jun 5;15:e92946. doi: 10.2196/92946. PMID- 42247658 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260908 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jun 5 TI - Screen-Free Time With Friends to Promote Face-to-Face Peer Interaction and Reduce Recreational Screen Use Among Children Aged 9-11 Years: Protocol for a Cluster Randomized Controlled Trial. PG - e84831 LID - 10.2196/84831 [doi] LID - e84831 AB - BACKGROUND: Children's leisure time has changed in recent decades-with more time spent on screen media and less time face-to-face with peers-potentially affecting their physical and mental well-being. OBJECTIVE: This protocol outlines a cluster randomized controlled trial evaluating the Screen-Free Time With Friends intervention, which aims to promote face-to-face peer interaction and reduce recreational screen media use among children aged 9-11 years. METHODS: The study is conducted as a cluster randomized controlled trial involving 9-11-year-old children and their parents from 18 schools in Denmark. Schools are randomized (1:1) to either a control or an intervention group. The intervention includes five core components: (1) curricular activities, (2) two family meetings, (3) a brief parent exercise, (4) a development program for after-school clubs, and (5) two community workshops. It is designed to allow local adaptation while maintaining fidelity to the core components. Primary and key secondary outcomes, including face-to-face peer interaction across leisure domains and solitary screen time, are assessed at baseline, 6-10 months, and 13-15 months follow-up. Additional exploratory outcomes (e.g., leisure activities, social relations, and well-being) are measured at baseline and follow-up. Time spent in face-to-face interactions with peers was assessed using a short SMS-based questionnaire sent to registered parents. The instrument has not been formally validated but was tested in a feasibility study. A comprehensive process evaluation explores implementation, context, and mechanisms of change. RESULTS: The project was funded in July 2020. Schools were recruited from July 2023 to January 2024, while children and parents were recruited from November 2023 to April 2024. At baseline, 685 children were enrolled at the participating schools, with 343 (50%) having at least one parent enrolled in the questionnaire. The primary outcome is therefore assessed among a subset of participants, which may affect the effective sample size. Baseline data were collected from December 2023 to June 2024, and follow-up data from March to August 2025. As of March 2026, data analysis has not yet commenced, and no study results are currently available. Findings are expected to be published by the end of 2026. CONCLUSIONS: Regardless of the findings, this study will generate important knowledge about the intervention's potential effectiveness, complemented by insights into its implementation, context, and mechanisms of change. These insights can assist municipalities, schools, after-school clubs, community stakeholders, and parents in shaping everyday environments that foster children's face-to-face interaction and encourage balanced screen use. The findings may inform policy decisions, guide the development of new national and local initiatives, and inspire future research into feasible, real-world interventions that support meaningful and enriching leisure experiences for children. CI - (c) Sara Kruse Lange, Sarah Overgaard Slater, Teresa Victoria Hoy, Kristian Traberg Larsen, Anders Blaedel Gottlieb Hansen, Russell Jago, Peter Lund Kristensen, Anders Grontved, Mette Toftager, Anne Kaer Gejl. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Lange, Sara Kruse AU - Lange SK AUID- ORCID: 0009-0003-6477-2325 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Sorensen, Sarah Overgaard AU - Sorensen SO AUID- ORCID: 0000-0002-3953-3387 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Hoy, Teresa Victoria AU - Hoy TV AUID- ORCID: 0000-0002-2452-1535 AD - National Institute of Public Health, Faculty of Health Sciences, University of Southern Denmark, Copenhagen, Denmark. FAU - Larsen, Kristian Traberg AU - Larsen KT AUID- ORCID: 0000-0002-3918-6645 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Hansen, Anders Blaedel Gottlieb AU - Hansen ABG AUID- ORCID: 0000-0001-6777-2257 AD - Center for Clinical Research and Prevention, Copenhagen University Hospital, Frederiksberg, Denmark. FAU - Jago, Russell AU - Jago R AUID- ORCID: 0000-0002-3394-0176 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Kristensen, Peter Lund AU - Kristensen PL AUID- ORCID: 0000-0002-5666-9614 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Grontved, Anders AU - Grontved A AUID- ORCID: 0000-0003-1584-679X AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Toftager, Mette AU - Toftager M AUID- ORCID: 0000-0002-6736-3725 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Gejl, Anne Kaer AU - Gejl AK AUID- ORCID: 0000-0001-6781-2263 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. LA - eng SI - ClinicalTrials.gov/NCT06163495 PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260605 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - Denmark MH - *Friends/psychology MH - Interpersonal Relations MH - Leisure Activities MH - *Peer Group MH - *Screen Time MH - Surveys and Questionnaires MH - Randomized Controlled Trials as Topic PMC - PMC13240986 OTO - NOTNLM OT - after-school programs OT - child OT - community participation OT - digital media use OT - interpersonal relations OT - mental health OT - physical activity OT - screen time OT - social interaction OT - well-being COIS- Conflicts of Interest: None declared. EDAT- 2026/06/05 18:36 MHDA- 2026/06/11 05:42 PMCR- 2026/06/05 CRDT- 2026/06/05 16:12 PHST- 2025/09/26 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/11 05:42 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 16:12 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - v15i1e84831 [pii] AID - 84831 [pii] AID - 10.2196/84831 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jun 5;15:e84831. doi: 10.2196/84831. PMID- 42247646 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jun 5 TI - Digital and Blended Lifestyle Interventions for Preschool-Aged Children and Families With a Low Socioeconomic Position and the General Population: Scoping Review. PG - e86596 LID - 10.2196/86596 [doi] LID - e86596 AB - BACKGROUND: Many unhealthy habits develop in early childhood and can lead to long-term health risks, which disproportionately affect children with low socioeconomic position (SEP). Digital and blended lifestyle interventions can promote healthier lifestyles, yet families with lower SEP remain underrepresented and face unique barriers to healthy behaviors and intervention access. As a result, it remains unclear which intervention characteristics are most effective for these populations. OBJECTIVE: This study aimed to identify and map digital and blended lifestyle interventions targeting preschool-aged children and explore how intervention characteristics and reported effectiveness patterns differ between interventions for the general population and low SEP families. METHODS: A search across Scopus, Web of Science, Cochrane Library, ERIC, and ACM Digital Library was conducted. Studies were eligible if they (1) targeted preschool-aged children (6 months to 5 years) or caregivers, (2) evaluated a digital or blended lifestyle intervention, and (3) addressed at least one behavioral domain (nutrition, physical activity, sedentary behavior, sleep, and oral health). Studies focusing on pregnant women, children aged >5 years, or interventions delivered solely nondigitally were excluded. Screening and prioritization were supported by artificial intelligence-assisted software (ASReview; Utrecht University). Data covered intervention targets, populations, theoretical and guideline foundations, delivery modes and settings, and persuasive systems design features. Intervention characteristics and effectiveness categories were synthesized descriptively. The methodological quality of quasi-experimental studies was assessed using the Joanna Briggs Institute critical appraisal tools. RESULTS: A total of 77 studies describing 54 interventions were included. Of these, 35 targeted the general population, and 19 focused solely on low SEP families. Interventions were similar across groups: typically parent-focused, targeting multiple lifestyle domains, and informed by theories, frameworks, or evidence-based guidelines. Low SEP interventions more often used text messaging, included fewer persuasive design features, and tended toward single delivery channels. Effectiveness findings were mixed; no consistent patterns emerged when interventions were grouped by their characteristics. Among low SEP interventions only, less effective interventions more often targeted multiple behaviors and included more persuasive systems design features. CONCLUSIONS: To our knowledge, this is one of the first reviews to map digital and blended lifestyle interventions for preschool-aged children while comparing intervention characteristics and descriptive effectiveness patterns across general and low SEP populations. The review highlights heterogeneity in intervention characteristics and outcomes and identifies gaps where evidence is limited. These findings underscore the need to better represent low SEP families in intervention research, strengthen understanding of feasibility and contextual fit, and support multilevel approaches that reflect families' everyday contexts. However, the findings should be interpreted in light of several limitations, including the exclusion of gray literature, partial double-screening, the possibility that artificial intelligence-assisted prioritization may have omitted relevant studies, and variation in the reporting of intervention components across studies. CI - (c) Lea Hohendorf, Tessa Dekkers, Hanneke Kip, Laurence Alpay, Saskia M Kelders. Originally published in the Journal of Medical Internet Research (https://www.jmir.org). FAU - Hohendorf, Lea AU - Hohendorf L AUID- ORCID: 0009-0000-3738-6320 AD - Health Psychology & Technology, Faculty of Behavioural, Management and Social Sciences, University of Twente, Drienerlolaan 5, Enschede, Overijssel, 7522 NB, The Netherlands, 49 1708162426. AD - Medical Technology Research Group, Faculty of Healthcare, Sport & Well-being, Inholland University of Applied Sciences, Haarlem, The Netherlands. FAU - Dekkers, Tessa AU - Dekkers T AUID- ORCID: 0000-0003-2787-3293 AD - Health Psychology & Technology, Faculty of Behavioural, Management and Social Sciences, University of Twente, Drienerlolaan 5, Enschede, Overijssel, 7522 NB, The Netherlands, 49 1708162426. FAU - Kip, Hanneke AU - Kip H AUID- ORCID: 0000-0002-6661-2128 AD - Health Psychology & Technology, Faculty of Behavioural, Management and Social Sciences, University of Twente, Drienerlolaan 5, Enschede, Overijssel, 7522 NB, The Netherlands, 49 1708162426. AD - Department of Research, Stichting Transfore, Deventer, The Netherlands. FAU - Alpay, Laurence AU - Alpay L AUID- ORCID: 0000-0002-8243-0607 AD - Medical Technology Research Group, Faculty of Healthcare, Sport & Well-being, Inholland University of Applied Sciences, Haarlem, The Netherlands. FAU - Kelders, Saskia M AU - Kelders SM AUID- ORCID: 0000-0001-8949-6871 AD - Health Psychology & Technology, Faculty of Behavioural, Management and Social Sciences, University of Twente, Drienerlolaan 5, Enschede, Overijssel, 7522 NB, The Netherlands, 49 1708162426. AD - Optentia Research Focus Area, Vaal Triangle Campus, North-West University, Vanderbijlpark, South Africa. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260605 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - Child, Preschool MH - *Life Style MH - Low Socioeconomic Status MH - *Health Promotion/methods MH - Digital Media MH - Digital Health MH - Infant PMC - PMC13240985 OTO - NOTNLM OT - digital health interventions OT - eHealth OT - effectiveness OT - health behaviors OT - intervention characteristics OT - intervention evaluation OT - lifestyle interventions OT - low socioeconomic position OT - persuasive systems design OT - preschool-aged children COIS- Conflicts of Interest: None declared. EDAT- 2026/06/05 18:36 MHDA- 2026/06/11 06:36 PMCR- 2026/06/05 CRDT- 2026/06/05 16:03 PHST- 2025/10/27 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/11 00:00 [accepted] PHST- 2026/06/11 06:36 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 16:03 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - v28i1e86596 [pii] AID - 86596 [pii] AID - 10.2196/86596 [doi] PST - epublish SO - J Med Internet Res. 2026 Jun 5;28:e86596. doi: 10.2196/86596. PMID- 42247287 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260711 IS - 1744-8409 (Electronic) IS - 1744-666X (Linking) VI - 22 IP - 6 DP - 2026 Jun TI - Measuring disease activity in juvenile systemic sclerosis: a multidisciplinary consensus from the Hamburg 2024 symposium. PG - 645-660 LID - 10.1080/1744666X.2026.2685050 [doi] AB - INTRODUCTION: Assessment of disease activity in juvenile systemic sclerosis (jSSc) is essential for clinical care and trial readiness, yet no validated pediatric activity measures exist. Adult systemic sclerosis activity tools, including the Scleroderma Clinical Trials Consortium Activity Index, revised CRISS, and revised EUSTAR, provide conceptual frameworks but require adaptation for developmental, physiologic, and feasibility considerations for children. At the 17th Hamburg Symposium on JSSc, an international multidisciplinary panel reviewed adult indices, evaluated corresponding variables in the jSSc Inception Cohort and the NRCOS registry, and conducted a structured Delphi process to define organ-specific indicators of clinically meaningful activity in jSSc. AREAS COVERED: Across skin, pulmonary, cardiac, vascular, musculoskeletal, gastrointestinal, renal, and global domains, the panel reached broad and often unanimous consensus on variables reflecting active, potentially reversible disease. Key endorsed measures included mRSS progression, new ILD on HRCT, >/=10% declines in FVC or DLCO, new cardiac abnormalities, active digital ulcers, synovitis, myositis, nutritional decline, and physician global assessment. Patient-reported outcomes were strongly supported across domains. EXPERT OPINION: These consensus-derived indicators provide the first comprehensive pediatric-specific foundation for defining disease activity in jSSc and represent a critical step toward developing and validating a unified pediatric activity index suitable for future clinical trials. FAU - Foeldvari, Ivan AU - Foeldvari I AUID- ORCID: 0000-0003-0659-5298 AD - Hamburg Centre for Pediatric and Adolescent Rheumatology, Schon Klinik Hamburg Eilbek, Hamburg, Germany. FAU - Torok, Kathryn S AU - Torok KS AD - Division of Pediatric Rheumatology, UPMC & University of Pittsburgh Scleroderma Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Klotsche, Jens AU - Klotsche J AD - German Rheumatism Research Center, Berlin, Germany. FAU - Li, Jonathan C AU - Li JC AD - Division of Pediatric Rheumatology, UPMC & University of Pittsburgh Scleroderma Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Bruni, Cosimo AU - Bruni C AD - Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Costa-Reis, Patricia AU - Costa-Reis P AD - Pediatrics Department, Hospital de Santa Maria, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. FAU - Cutolo, Maurizio AU - Cutolo M AD - Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology-Department of Internal Medicine and Specialties, University of Genoa and IRCCS San Martino Polyclinic Hospital, Genoa, Italy. FAU - Denton, Christopher P AU - Denton CP AD - UCL Division of Medicine, Royal Free London NHS Foundation Trust, London, UK. FAU - Fligelstone, Kim AU - Fligelstone K AD - Scleroderma & Raynaud's United Kindgom (SRUK) (Research Subcommittee, Patient Research Partner), FESCA, London, UK. FAU - Del Galdo, Francesco AU - Del Galdo F AD - Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Biomedical Research Centre, Leeds Teaching Hospital Trust, Leeds, UK. FAU - Gimenez-Roca, Clara AU - Gimenez-Roca C AD - Department of Pediatric Rheumatology, Hospital Sant Joan de Deu, Esplugues de Llobregat (Barcelona), Spain. FAU - Henes, Jorg AU - Henes J AD - Centre for Interdisciplinary Clinical Immunology, Rheumatology and Autoinflammatory Diseases and Department for Internal Medicine II, University Hospital Tubingen, Tubingen, Germany. FAU - Kasapcopur, Ozgur AU - Kasapcopur O AD - Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University - Cerrahpasa, Istanbul, Turkey. FAU - Li, Suzanne C AU - Li SC AD - Joseph M Sanzari Children's Hospital, Hackensack Meridian School of Medicine, Hackensack, NJ, USA. FAU - Marrani, Edoardo AU - Marrani E AD - Pediatric Rheumatology, Meyer Children's Hospital IRCCS, Firenze, Italy. FAU - Orteu, Catherine H AU - Orteu CH AD - UCL Institute of Immunity and Transplantation, Royal Free London NHS Foundation Trust, London, UK. FAU - Pauling, John D AU - Pauling JD AD - North Bristol NHS Trust, Bristol, UK. FAU - Pilkington, Clarissa AU - Pilkington C AD - Pediatric Rheumatology, Great Ormond Street Hospital, London, UK. FAU - Ross, Laura AU - Ross L AD - Department of Medicine, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia. AD - Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Australia. FAU - Schonenberg-Meinema, Dieneke AU - Schonenberg-Meinema D AD - Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands. FAU - Furst, Daniel E AU - Furst DE AD - Rheumatology, University of California, Los Angeles, CA, USA. AD - University of Washington, Seattle, WA, USA. AD - Pediatric Rheumatology, University of Florence, Florence, Italy. FAU - Smith, Vanessa AU - Smith V AD - Department of Internal Medicine, Ghent University, Ghent, Belgium. AD - Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. AD - Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium. AD - Rheumatology, ERN ReCONNET, Ghent, Belgien. LA - eng GR - Scleroderma Clinical Trial Consortium/ GR - National Scleroderma Foundation/ PT - Consensus Statement PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20260622 PL - England TA - Expert Rev Clin Immunol JT - Expert review of clinical immunology JID - 101271248 RN - Juvenile systemic scleroderma SB - IM MH - Child MH - Humans MH - Disease Progression MH - *Scleroderma, Systemic/diagnosis MH - Severity of Illness Index OTO - NOTNLM OT - Clinical trials OT - consensus OT - disease activity OT - disease activity index OT - juvenile systemic sclerosis OT - outcome measures OT - pediatric rheumatology EDAT- 2026/06/05 18:36 MHDA- 2026/06/30 06:30 CRDT- 2026/06/05 12:33 PHST- 2026/06/30 06:30 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 12:33 [entrez] AID - 10.1080/1744666X.2026.2685050 [doi] PST - ppublish SO - Expert Rev Clin Immunol. 2026 Jun;22(6):645-660. doi: 10.1080/1744666X.2026.2685050. Epub 2026 Jun 22.