PubMed:
Provider: NLM
Database: PubMed (National Library of Medicine), https://pubmed.ncbi.nlm.nih.gov
Date(s) Searched: October 28, 2026
Language: English
Publication types excluded: Editorial, Letter, Case Reports, Preprint, Comment
Animal-only studies excluded: animals[mh] NOT humans[mh]
Final count: 1,534 (line 11)
Search Terms:

No. | Query | Results
1 | "Wounds and Injuries"[Mesh] OR "Multiple Trauma"[Mesh] OR "Shock, Hemorrhagic"[Mesh] OR "Trauma Centers"[Mesh] | 1,118,508
2 | trauma*[tiab] OR injur*[tiab] OR polytrauma*[tiab] OR casualt*[tiab] OR battlefield[tiab] OR wounded[tiab] | 1,588,009
3 | 1 OR 2 | 2,195,865
4 | "Thrombelastography"[Mesh] | 6,734
5 | thromboelastogra*[tiab] OR thrombelastogra*[tiab] OR thromboelastometr*[tiab] OR thrombelastometr*[tiab] OR TEG[tiab] OR ROTEM[tiab] OR ClotPro[tiab] OR Quantra[tiab] OR Sonoclot[tiab] OR "viscoelastic test*"[tiab] OR "viscoelastic assay*"[tiab] OR "viscoelastic hemostat*"[tiab] OR "viscoelastic haemostat*"[tiab] OR "viscoelastic coagulation"[tiab] OR "viscoelastic guided"[tiab] OR "viscoelastic monitoring"[tiab] OR "viscoelastic method*"[tiab] OR "point-of-care coagulation"[tiab] | 11,683
6 | viscoelastic[ot] | 2,114
7 | 4 OR 5 OR 6 | 14,793
8 | 3 AND 7 | 2,117
9 | "Editorial"[Publication Type] OR "Letter"[Publication Type] OR "Case Reports"[Publication Type] OR "Preprint"[Publication Type] OR "Comment"[Publication Type] OR (animals[mh] NOT humans[mh]) | 10,282,724
10 | 8 NOT 9 | 1,622
11 | 10 AND english[la] | 1,534
12 | "Blood Transfusion"[Mesh] OR "Hemorrhage"[Mesh] OR "Mortality"[Mesh] | 913,516
13 | transfus*[tiab] OR hemorrhag*[tiab] OR haemorrhag*[tiab] OR bleeding[tiab] OR mortality[tiab] | 1,887,144
14 | 12 OR 13 | 2,319,897

Final query as run through NCBI E-utilities (line 11):
(((("Wounds and Injuries"[Mesh] OR "Multiple Trauma"[Mesh] OR "Shock, Hemorrhagic"[Mesh] OR "Trauma Centers"[Mesh]) OR (trauma*[tiab] OR injur*[tiab] OR polytrauma*[tiab] OR casualt*[tiab] OR battlefield[tiab] OR wounded[tiab])) AND (("Thrombelastography"[Mesh]) OR (thromboelastogra*[tiab] OR thrombelastogra*[tiab] OR thromboelastometr*[tiab] OR thrombelastometr*[tiab] OR TEG[tiab] OR ROTEM[tiab] OR ClotPro[tiab] OR Quantra[tiab] OR Sonoclot[tiab] OR "viscoelastic test*"[tiab] OR "viscoelastic assay*"[tiab] OR "viscoelastic hemostat*"[tiab] OR "viscoelastic haemostat*"[tiab] OR "viscoelastic coagulation"[tiab] OR "viscoelastic guided"[tiab] OR "viscoelastic monitoring"[tiab] OR "viscoelastic method*"[tiab] OR "point-of-care coagulation"[tiab]) OR (viscoelastic[ot]))) NOT ("Editorial"[Publication Type] OR "Letter"[Publication Type] OR "Case Reports"[Publication Type] OR "Preprint"[Publication Type] OR "Comment"[Publication Type] OR (animals[mh] NOT humans[mh]))) AND english[la]

AI-use statement:
The PubMed search strategy was drafted with the PICO search builder. It used the large language model claude-opus-5-5 (Anthropic; accessed October 28, 2026) to propose search concepts and terms from the review question. The tool made 1 call to the model at high effort (the draft); claude-opus-5-5 was requested and answered it. A refusal fallback was enabled (had the model declined a request, the API could have run it again on another model Anthropic recommends); it was not used. Every MeSH heading, Supplementary Concept and publication type the strategy searches was checked against NLM MeSH (id.nlm.nih.gov) before use: 13 valid. Each numbered line was run in PubMed through NCBI E-utilities on October 28, 2026, and PubMed's own diagnostics (phrases not found, ignored words, lost truncation) were checked. The strategy was tested against 3 known relevant studies that were not shown to the model: 3 were retrieved (95% CI 29%–100%). Retrieving known studies does not prove the search is complete. A searcher must review the strategy before it is used. The prompts, the model output and every version are in the provenance file (JSON export).

Review question: What are the benefits and harms of Viscoelastic testing-guided clinical care (i.e., transfusion strategies) for patient important outcomes (e.g., mortality, bleeding events) as compared with transfusion guided by any other method in adult patients experiencing major trauma and blood loss?
Run 360d6830-5eb8-454c-a159-3ba072c7a290, exported October 29, 2026 from the PICO search builder.